baber/WOPTO huggingface dataset:
Patent NZ-510988-A (NZ)
Title: N-aralkylaminotetralins useful as ligands for the neuropeptide Y5 receptor
Inventor: DAX SCOTT L
IPC: A61P25/28
Filed: 1999-10-06
Abstract: The compounds of formula (I) and (II) are described wherein: R1 is selected from hydroxy; halo; C1-8alkyl; C1-8alkoxy; substituted C1-8alkoxy wherein the substituent is selected from halo, such as chloro, bromo, fluoro and iodo; trifluoroalkyl; C1-8alkylthio; substituted C1-8alkylthio wherein the substituent is selected from halo, such as chloro, bromo, fluoro and iodo, trifluoroalkyl and C1-8alkoxy; C3-6cycloalkyl; C3-8cycloalkyloxy; nitro; amino; C1-6alkylamino; C1-8dialkylamino; C4-8cycloalkylamino; cyano; carboxy; C1-5alkoxycarbonyl; C1-5alkylcarbonyloxy; formyl; carbamoyl; phenyl; and substituted phenyl wherein the substitutent is selected from halo, hydroxyl, nitro, amino and cyano; n is 0-2; R2 is selected from hydrogen; C1-6alkyl; C2-6alkenyl; halo, such as fluoro and chloro; C3-7cycloalkyl; phenyl; substituted phenyl wherein the substituent is selected from halo, C1-6alkyl, C1-6alkoxy, trifluoroC1-6alkyl, cyano, nitro, amino, C1-6alkylamino, and C1-6dialkylamino; naphthyl; phenoxy; substituted phenoxy wherein the substituent is selected from halo, C1-6alkyl, C1-6alkoxy, trifluoroC1-6alkyl, cyano and nitro; phenylthio and substituted phenylthio wherein the substituent is selected from halo, C1-6alkyl, nitro and amino; a heteroaryl group such pyridyl, pyrimidyl, furyl, thienyl, and imidazolyl; and substituted heteroaryl wherein the substituent is selected from C1-6alkyl and halo; provided that R2 is no methyl; L is selected from the group consisting of C1-8alkylene; C2-8alkenylene; C2-8alkynylene; and C1-4alkyleneC3-8cycloalkylene; or L' is selected from the group consisting of C1-7alkylene; C2-7alkenylene; C2-7alkynylene; and C1-3alkyleneC3-8cycloalkylene; and R3 is selected from C1-8alkyl; substituted C1-8alkyl wherein the substituent is selected from alkoxy and halo; alkoxyalkyloxy; substituted cycloalkyl wherein the substituent is selected from alkoxy and halo; phenyl; substituted phenyl wherein the substituent is selected from C1-8alkyl, halo, nitro, amino, alkylamino, alkylsulfonyl, alkoxy and cyano; naphthyl; substituted naphthyl wherein the substituent is selected from halo, nitro, amino and cyano; heteroaryl wherein the heteroaryl group is selected from indolyl, pyridyl, pyrimidyl, furyl, thienyl and imidazolyl; and substituted heteroaryl wherein the substituent is selected from halo, nitro, amino and cyano. Pharmaceutical compositions comprising the compounds of formula (I) or (II) are useful for treating diseases associated with NPY receptor subtype Y5 such as eating disorders, obesity, bulimia nervosa, diabetes, dyspilipidmia, hypertension, memory loss, epileptic seizures, migraine, sleep disturbances, pain, sexual/reproductive disorders, depression, anxiety, cerebral hemorrhage, shock, congestive heart failure, nasal congestion or diarrhea.
Patent NZ-511029-A (NZ)
Title: Method and device for handling and thermally treating bag or film packagings
Inventor: KALISCH PETER
IPC: A23L3/02
Filed: 1999-11-02
Abstract: Described is a method for handling and thermally treating rectangular bag or film packagings (5) with a smaller thickness than length and width and with two longer and two shorter lateral edges. The method is characterized by an orientation of the film packagings (5) in which a principle extension plane of the film packagings containing the lateral edges forms an angle of less than 60 DEG with the verticals during handling and/or thermal treatment, and the longer edges are orientated in an essentially horizontal manner.
Patent NZ-511808-A (NZ)
Title: Transgenic bovine that produce the heterologous protein in milk
Inventor: BREMEL ROBERT D
IPC: A01K67/027
Filed: 1999-11-17
Abstract: Methods and compositions are described for the generation of transgenic non-human animals, i.e., bovines. The method involves the introduction of exogenous nucleic acid sequences into the genome of unfertilised eggs (e.g., pre-maturation oocytes and pre-fertilisation oocytes) by microinjection of an infectious retrovirus into the perivitelline space of the egg. Such methods provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals that are mosaic for the presence of the transgene.
Patent NZ-513189-A (NZ)
Title: Diagnosis of a personÆs risk for developing atherosclerosis or diabetic retinopathy
Inventor: KOULU MARKKU
IPC: C12Q1/68
Filed: 2000-03-29
Abstract: Methods for diagnosing a person's susceptibility for having an increased risk for the development of atherosclerosis and a diabetic person's susceptibility for having an increased risk for the development of diabetic retinopathy and treating persons diagnosed for having increased risk for the development of these diseases, in order to prevent the development of these diseases are disclosed.  The method for diagnosing an individual's susceptibility for having a risk for the development of atherosclerosis, comprising determining whether the individual subject has a polymorphism in the signal peptide part of the human preproNPY, the polymorphism comprising the substitution of the position 7 leucine for proline in the signal peptide part of the preproNPY, and the polymorphism being indicative of an increased risk for the development of atherosclerosis.  Methods to investigate or screen pharmaceuticals or genetic aims useful in the treatment of these diseases, by using an animal model including a transgenic animal are also disclosed.
Patent NZ-513288-A (NZ)
Title: Pin type insulator core molded with radial ribs on outer surface to avoid shrink cavities
Inventor: BROCARD EMMANUEL
IPC: H01B19/00
Filed: 2001-08-01
Abstract: The rod insulator I comprises an electrically insulating rigid core N obtained by molding, a bore T for receiving the rod, and an outer surface with a dielectric covering E obtained by molding. The shape of the outer surface has at least one groove C for supporting an electrical conductor, and fins A1 and A2 that are annular about the axis of the bore. The core is molded so that the outer surface has radial ribs R extending from the core, the ribs being spaced apart from each other by a distance equal to the thickness of the core. The core and the dielectric covering may be molded of the same material or differing materials.
Patent NZ-515664-A (NZ)
Title: Benzimidazole derivatives useful as respiratory syncytial virus replication inhibitors
Inventor: JANSSENS FRANS EDUARD
IPC: C07B61/00
Filed: 2000-06-20
Abstract: A benzimidazole or imidazopyridine derivative or a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof has the formula (I) wherein: -al=a2-a3=a4- is -CH=CH-CH=CH- (a-1); -N=CH-CH=CH- (a-2); -CH=N-CH=CH- (a-3); -CH=CH-N=CH- (a-4); or -CH=CH-CH=N- (a-5) and each hydrogen atom in the radicals (a-1), (a-2), (a-3), (a-4) and (a-5) may optionally be replaced by halo, alkyl, nitro, amino, hydroxy, alkyloxy, polyhaloalkyl, carboxyl, aminoalkyl, mono-or dialkyl-aminoalkyl, alkyloxycarbonyl, hydroxyalkyl, or -C(=Z)-aryl; Z is =O, =CH-C(=O)-NR5aR5b, =CH2, =CH-alkyl, =N-OH or =N-O-alkyl; Q is a radical of formula (b-1) to (b-8); Alk is alkanediyl and Y1 is -NR2- or -CH(NR2R4)-; X1 is NR4, S(O)n', O, CH2, C(=O), C(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2-NR4 or NR4-CH2; X2 is a direct bond, CH2, C(=O), NR4, alkyl-NR4, or NR4-alkyl; t is 2 to 5; u is 1 to 5 v is 2 or 3; and n' is 0 to 2; each hydrogen atom in Alk and the carbocycles and the heterocycles defined in radicals (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8) may optionally be replaced by R3 with the proviso that when R3 is hydroxy or alkyloxy, then R3 can not replace a hydrogen atom in the a position relative to a nitrogen atom; G is substituted alkanediyl; R1 is optionally substituted phenyl, piperidinyl, piperazinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, or oxadiazolyl; R2 is hydrogen, formyl, alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, cycloalkyl substituted with N(R6)2, or alkyl substituted with N(R6)2 and can be further substituted; R3 is hydrogen, hydroxy, alkyl, alkyloxy, arylalkyl or arylalkyloxy and R4 is hydrogen, alkyl or arylalkyl; R5a and R5b are as defined in the specification and Het is pyridyl, pyrimidinyl or pyridazinyl. An intermediate of formula IV, IX or XXII is described wherein: P is a protecting group; Q1 is as defined for Q above and -al=a2-a3=a4-, G and R1 are as defined above; (O-)Q3 is a carbonyl derivative of Q and (O=)-G2 is a carbonyl derivative of G. The compounds are useful as respiratory syncytial virus replication inhibitors.
Patent NZ-518032-A (NZ)
Title: Substituted imidazole derivatives
Inventor: ADAMS JERRY L
IPC: C07D401/04
Filed: 2000-11-20
Abstract: Compounds of formula(I) that inhibit the kinase activity of the Tie2 receptor and block its signal transduction , and thus are useful in treating disorders caused by excessive angiogenesis.
Patent NZ-521806-A (NZ)
Title: Compositions and methods for induction of proteins involved in xenobiotic metabolism
Inventor: RAUCY JUDY
IPC: C12N5/08
Filed: 2001-04-11
Abstract: An isolated cell comprising a first nucleic acid molecule comprising: a promoter or enhancer operable for a nucleic acid molecule encoding a protein involved in drug metabolism operably linked to a reporter gene; and a second nucleic acid encoding an intracellular receptor or transcription factor, wherein when said receptor or transcription factor is bound with, associated with or activated by a compound, said intracellular receptor or transcription factor can operably bind with, associate with or activate said promoter or enhancer resulting in the expression of said reporter gene; wherein said cell is contacted with a compound that induces the expression of said protein involved in drug metabolism, said reporter gene is expressed.
Patent NZ-526364-A (NZ)
Title: Improvements to safety and reflective vests
Inventor: TURNER KEVIN WILLIAM
Filed: 2003-06-06
Abstract: A safety garment (see Fig 5) made from a number of panels formed and arranged to break-away from one another in the event that the garment or part of the garment becomes snagged or caught. The garment is formed from at least front and back panels adjoined to one another via a selectively disengageable means such as hook and loop fasteners, snap fasteners, re-attachable adhesive patches and the like.
Patent NZ-526813-A (NZ)
Title: Humanized antibodies that recognize beta amyloid peptide
Inventor: BASI GURIQ
IPC: C07K16/00
Filed: 2001-12-06
Abstract: A humanized immunoglobulin light chain comprises: (i) a variable region complementarity determining regions (CDRs) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2; and (ii) a variable framework region from a human acceptor immunoglobulin light chain sequence, provided that at least one framework residue is substituted with the corresponding amino acid residue from the mouse 3D6 light chain variable sequence, wherein the framework residue is selected from the group consisting of: (a) a residue that non-covalently binds antigen directly; (b) a residue adjacent to a CDR (c) a CDR-interacting residue; and (d) a residue participating in the VL-VH interface. Also described are pharmaceutical compositions comprising a suitable amount of the immunoglobulin or antigen binding fragment for the prevention or treatment of an amyloidogenic disease for example, Alzheimer's disease.
Patent NZ-526938-A (NZ)
Title: Therapeutic agent comprising a B-subunit of a protein toxin in conjunction with EBV latent mambrane protein useful for the treatment of diseases associated with the Epstein Barr Virus and neoplasias
Inventor: MORGAN ANDREW JOHN
IPC: A61K47/48
Filed: 2001-12-11
Abstract: A B-subunit of a protein toxin selected from the B-subunit of E. coli heat-labile enterotoxin (EtxB) and the B-subunit of Vibrio cholerae toxin (CtxB) in conjunction with an Epstein Barr Virus latent membrane protein LMP-1 or LMP-2 has a therapeutic effect against cell surface-expressed viral antigens and tumour antigens. In particular, the protein toxin may be used to treat an animal body, including human, suffering from a disease or condition associated with Epstein Barr Virus or suffering from neoplasia.
Patent NZ-530512-A (NZ)
Title: Active substance combination for medicamentous therapy of nicotine dependency
Inventor: MOORMANN JOACHIM
IPC: C07D487/04
Filed: 2002-07-05
Abstract: Active ingredient combination comprising at least one inhibitor of cholinesterase, which inhibitor also acts on dopaminergic nerve endings, with at least one substance modulating the opioid receptor system, for the pharmacological therapy of nicotine dependence is disclosed.
Patent NZ-531070-A (NZ)
Title: Surgical implant
Inventor: UNWIN PAUL
IPC: A61L27/56
Filed: 2002-08-12
Abstract: A surgical implant comprises a core region and a porous surface region extending over at least a part of said core region. The porous surface region has a predetermined pore volume fraction. A method of manufacturing a surgical implant in accordance with the invention comprises the steps of: (i) loading metallic powder having a predetermined particle size distribution around a pre-formed core in a sealable capsule; (ii) reducing pressure within said capsule to a predetermined pressure below atmospheric pressure; (iii) pressurising said capsule with a process gas to a predetermined pressure higher than the predetermined pressure of step (ii); (iv) sealing said capsule; (v) heating said pressurised sealed capsule at an elevated temperature and an elevated pressure for a predetermined time to produce an implant precursor; (vi) cooling said sealed capsule, and; (vii) heating said implant precursor for a predetermined time at an elevated temperature and a predetermined pressure below atmospheric pressure, whereby to generate porosity in said implant precursor
Patent NZ-534115-A (NZ)
Title: Printing apparatus
Inventor: CRAIG JAMES THOMAS
IPC: B41J11/00
Filed: 2004-07-13
Abstract: A printer for printing an image on an image receiving material (2) provided on a backing material (10). The backing material having regularly spaced markings (6) provided on the back thereof. The printer comprises: - (a) A means of detecting the markings on the back of the backing material; (b) A means for determining at least one of the spacing (C) between two markings and the width of a marking (A); and (c) A means of comparing the determined marking width and/or spacing with a respective reference value and for causing printing to be stopped if at least one of the determined spacing and/or width differs from the respective reference value by more than a predetermined amount.
Patent NZ-535175-A (NZ)
Title: Fastener for spacing object from substrate
Inventor: LAT GEROMINO E
IPC: B25C5/02
Filed: 2004-09-08
Abstract: A fastener for holding and spacing an object at a predetermined distance from a substrate comprising a bridge portion and a first prong extending in a driving direction from said bridge portion. A second prong is spaced from said first prong and extends generally parallel thereto in the driving direction from said bridge portion wherein said second prong is substantially shorter than said first prong, and wherein said fastener is made from a shaped wire.
Patent NZ-536106-A (NZ)
Title: Preparation of polymers in a solid state
Inventor: SULSER UELI
IPC: C04B40/00
Filed: 2003-03-19
Abstract: Disclosed herein are polymers in a solid state which are obtained by the reaction of at least one polymer (A), produced from at least one monomer (a), selected from unsaturated mono- or di-carboxylic acids, or analogues of unsaturated mono- or di-carboxylic acids and optionally at least one ethylenically-unsaturated monomer (b) with at least one polymer (B) which is terminated at one end by terminal groups which are non-reactive under normal reaction conditions and hydroxy- or amino-functionalised at the other end thereof and, optionally, at least one amine (C). Also disclosed are polymers in a solid sate which are obtained by the reaction of at least one monomer (a), selected from unsaturated mono- or di-carboxylic acids or analogues of unsaturated mono- or di-carboxylic acids in the presence of a radical initiating agent with at least one monomer (c), selected from the group of unsaturated esters or amides of a polymer (B), terminated at one end by terminal groups which are non-reactive under normal reaction conditions and hydroxy- or amino-functionalised at the other end thereof, with optionally at least one ethylenically unsaturated monomer (b). The production and use of solid polymers as dispersants and fluidising agents in cement systems is also disclosed.
Patent NZ-538666-A (NZ)
Title: Open web trimmable truss with self locking joint
Inventor: BRIGHTWELL LIONEL L
IPC: B60B19/02
Filed: 2005-03-08
Abstract: A wood containing, open web trimmable truss assembly composed of opposed chord members defining an open web central structure that is bounded at each ends by a closed, trimmable end block. The open web central structure is formed by a plurality of web elements attached to the chord members via a mortise and tenon coupling. The trimmable end block is attached to both chord members and the outer most web element.
Patent NZ-542433-A (NZ)
Title: Device for water decomposition by electrolysis
Inventor: SURIKOV ALEKSANDR KONSTANTINOV
IPC: C25B9/12
Filed: 2003-09-18
Abstract: A plant for decomposition of water by electrolysis is disclosed. The plant comprises lines for supplying water and electrolyte and for extracting electrolysis products and an electrolyzer having a body installed on a shaft connected to a drive and incorporating ducts for supplying electrolyte solution and extracting the electrolysis products as well as an electrolyte solution drain duct. The plant also has short-circuited electrodes and a heat exchanger. One electrode is installed on the shaft and the other one formed by the internal surface of the body. The plant is provided with top and bottom bearing units holding a vertical shaft. The external electrolyte solution circulation path contains the electrolyte solution ring chamber with a helix-shaped internal surface which is fixed to the top bearing unit. The electrolyte solution sensor is installed and the electrolyte solution mixer is connected to water and electrolyte supply lines as well as to the electrolyte solution supply duct. The electrolyte solution extraction channel located in the top cover is equipped with an adjustable valve connected to the electrolyte solution ring chamber. The electrolyzer body is made of electrically conducting material and is provided with bottom and top covers made of electrically conducting material. The water supply line is equipped with a water flow regulator and the electrolysis products extraction line is provided with an electrolysis products pumping device. The heat exchanger is located in the external electrolyte solution circulation circuit and the electrolyte solution sensor is connected to the water flow regulator and the shaft drive.
Patent NZ-542777-A (NZ)
Title: Genes in Group B Streptococcus (GBS), and also related organisms, the products of which are associated with the outer surface of the organism, and are useful as targets for immunotherapy
Inventor: HUGHES MARTIN JOHN GLENTON
IPC: C12N9/22
Filed: 1999-12-22
Abstract: A peptide encoded by the nucleotide sequence of SEQ ID NO: 9, or a homologue having greater than 70% sequence similarity is described. The peptide sequence can be the amino acid sequence of SEQ ID NO: 10 and can be obtained from Group B streptococcus. The peptide or polynucleotide can be used in a medicament for the treatment of bacterial infections, preferably when the infection is a focal or urinary tract infection. Also described are antibodies and hosts transformed with the peptide.
Patent NZ-544815-A (NZ)
Title: Improvements in and relating to the analysis of DNA
Inventor: GILL PETER
IPC: C12Q1/68
Filed: 2004-07-09
Abstract: A method of providing information on the likelihood of a result arising due to contamination in a method of analysis is provided. The method of analysis must include a threshold which determines the analysis protocol to be applied to the analysis of DNA in a test sample. The method of providing information about potential contamination includes the steps of obtaining information on whether or not DNA is suggested as present in any negative controls, determining the probability of DNA being suggested as present in the negative controls based on the number of negative controls suggesting DNA is present compared with the total number of negative controls considered, and equating the probability of DNA being suggested as present in the negative control to the probability of the DNA samples being contaminated. The method of providing information about potential contamination also includes obtaining information on whether or not DNA is suggested as present in a DNA sample, obtaining information about the quantity of DNA in the DNA sample, obtaining information on whether or not DNA is suggested as present in a negative control sample, obtaining information about the quantity of DNA in the negative control, simulating mixtures that pair negative control samples and DNA samples, establishing the proportion of mixtures where DNA is suggested as present from negative control sample only and/or establishing the proportion of mixtures where DNA is suggested as present from both the DNA sample and negative control sample, and determining a likelihood ratio in respect of a result arising which exceeds the threshold or which matches or exceeds the threshold in the method of analysis for one or both of the types of simulated mixture.
Patent NZ-547366-A (NZ)
Title: Method for production of thermally cured coatings
Inventor: JOHANSSON MATS KG
IPC: C09D/
Filed: 2004-11-25
Abstract: Disclosed is a method for production of a coating on a solid substrate, said method comprising the steps of: applying a liquid coating composition onto the substrate, said liquid coating composition comprising a polyfunctional resin, a fatty acid derivative selected from acyl-group containing mono- or polyfunctional akyl esters, a catalyst and optionally a curing agent, and/or one or more additives, wherein the polyfunctional resin comprises functional groups capable of reacting with acyl groups of the fatty acid derivative, and curing the liquid coating composition by heat activation. Also disclosed is a liquid coating composition, capable of curing by heat activation, said liquid coating composition comprising: a polyfunctional resin, a fatty acid derivative selected from acyl-group containing mono- or polyfunctional akyl esters, a catalyst, and optionally a curing agent, and/or one or more additives, wherein the polyfunctional resin comprises functional groups capable of reacting with acyl groups of the fatty acid derivative.
Patent NZ-549326-A (NZ)
Title: Extraction device and medical suturing device set
Inventor: FUNAMURA SHIGEAKI
Filed: 2006-08-21
Abstract: A surgical suture withdrawal device (30) for use in extracting a suture loop from within an organism to the outside of the organism, the surgical suture withdrawal device comprising a hollow needle (31) and an engagement member (32) movable within the needle and capable of catching onto a suture positioned within the organism and drawing at least part of the suture outside of the organism, the engagement member comprising a plurality of hook elements.