Patent SG-11201808434W-A (SG)
Title: Antibodies recognizing tau
Inventor: BARBOUR ROBIN
IPC: G01N33/68
Filed: 2017-05-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111H1110111111111111111111111111011101111111011111110011111110111011111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/191560 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/18 (2006.01) G01N 33/68 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/IB2017/052544 CA, DZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 02 May 2017 (02.05.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/330,789 02 May 2016 (02.05.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PROTHENA BIOSCIENCES LIMITED GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, [IE/IE]; Adelphi Plaza, Upper George's Street, Dun UG, Laoghaire Co. Dublin A96 T927 (IE). TM), ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: BARBOUR, Robin; 250 Normandy Lane, Wal- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, nut Creek, California 94598 (US). DOLAN, Philip James; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 622 Edgewater Blvd. #303, Foster City, CA 94404, Foster TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — City, California 94404 (US). LIU, Yue; 815 Peary Lane, KM, ML, MR, NE, SN, TD, TG). Foster City, California 94404 (US). ALEXANDER, Svet- lana; 913 Hollenbeck Ave., Sunnyvale, California 94087 = (US). RENZ, Mark; 808 Murchison Dr., Millbrae, Califor- nia 94030 (US). = = (54) Title: ANTIBODIES RECOGNIZING TAU 1.8 1.6 = 1.4 = 1.2 = to = 6.6 = = 0.6 = 0.4 = — = 0.2 -0.2 _ 1-1 — -4- 43 E 2 - 0 1 1 , 12 cli 4' ER \"'„, , v) (.,„ R .vg-- - : - 4 c - ' z2t, - RF,2, - g --- E — sg ' 07 sr ll3 0 l , 1 ,.. . . , N 'cl,z, ,c,i, z p c 7, a' g. 2 77),A4-92A .., ,— -RzzimccQcs,4&c , :i44R8,7, Amcep.) .4 P © . V; r) 1-1 01 1-1 IN FIG. I 1-1 0 (57) : The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies ei and associated symptomatic deterioration. [Continued on next page] WO 2017/191560 Al D III Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.17(i)) — as to the applicant's entitlement to claim the priority of earlier application (Rule 4.17(iii)) the Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))