baber/WOPTO huggingface dataset:
Patent DE-60305043-T2 (DE)
Inventor: WANNERBERGER KRISTIN
IPC: A61K38/095
Filed: 2003-11-13
Granted: 2006-11-30
Abstract: The present invention relates to a blister pack for pharmaceutical use comprising blisters containing a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, and to said solid dosage form. In one embodiment it specifically relates to a blister pack for pharmaceutical use comprising blisters containing a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable adjuvant, diluent and/or carrier, wherein said solid dosage form is adapted to prevent moisture related degradation of said desmopressin.
Patent DE-60306652-T2 (DE)
Inventor: YOON HYE-SUNG
IPC: C08F297/02
Filed: 2003-01-23
Granted: 2007-07-05
Abstract: The present invention relates to AB or ABA type block copolymers comprising p-dioxanone A blocks, and segmented copolymer B blocks comprising epsilon-caprolactone and trimethylene carbonate. The block copolymers are well suited for use as general medical and surgical articles requiring high flexibility, excellent knot-security and rapid absorption.
Patent DE-60311907-T2 (DE)
Inventor: MUROTA YASUBUMI
IPC: B41N1/14
Filed: 2003-04-02
Granted: 2007-10-31
Abstract: A presensitized plate useful for making a lithographic printing plates comprises an aluminum substrate provided thereon with a photopolymerizable light-sensitive layer, wherein the light-sensitive layer comprises an ethylenically unsaturated bond-containing compound having at least three methacryloyl or acryloyl groups alone or in any combination in the molecule and the substrate is Substrate A, which has, on the surface, grained structures comprising medium waved structure whose average pore size ranges from 0.5. to 5µm and small waved structure whose average pore size ranges from 0.01 to 0.2µm, which are superimposed; or Substrate B, which has, on the surface, grained structures comprising large waved structure whose average wavelength ranges from 5 to 100µm, medium waved structure whose average pore size ranges from 0.5 to 5µm and small waved structure whose average pore size ranges from 0.01 to 0.2µm, which are superimposed. The presensitized plate permits the maintenance of the balance between the resistance to contamination and the printing durability of the resulting lithographic printing plate to a substantially high level, when forming a light-sensitive layer containing a methacryl or acryl compound having at least three functional groups on the substrate according to the present invention having a characteristic surface grained pattern.
Patent DE-60314699-T2 (DE)
Inventor: POPOVICH MICHAEL S
IPC: B25C1/18
Filed: 2003-09-18
Granted: 2008-07-24
Abstract: In a powder driven fastening tool, a channel (120) is included for feeding a strip (111) of explosive powder cartridges (113) to a firing mechanism. A trigger (160) is included for actuating the firing mechanism (130), wherein the trigger (160) is movable between a first position and a second position. An advancing lever (170) is pivotally coupled to the tool, the advancing lever having a strip engagement portion (171) for indexing the strip (111) which extends into the channel. An advance link (150) is cammingly engaged with the advancing lever (170) and is operationally associated with the trigger (160) so that the strip engagement portion (171) is in a first position in the channel (120) when the trigger is in the first position and so the strip engagement portion (171) is in a second position when the trigger is in the second position. <IMAGE>
Patent DE-60316249-T2 (DE)
Inventor: BAGLIN THOMAS JEAN LUDOVIC
IPC: H03L/
Filed: 2003-01-27
Granted: 2008-06-12
Abstract: The comparator according to the invention comprises a difference amplifier (DA) connected to a current mirror (CM) and a series connection of a first transistor (P4) and a second transistor (N5) connected between a first and a second operating potential (VDD, GND), wherein the control input of the first transistor (P4) is connected to the difference amplifier (DA) and the current mirror (CM). The comparator further comprises an inverter (INV2) connected to the first operating potential (VDD) and to the outputs of the first and second transistor (P4, N5). A third transistor (N6) is connected between the second operating potential (GND) and the output (NET2) of the difference amplifier (DA) wherein the control input of the third transistor (N6) is connected to the output of the inverter (INV2). <IMAGE>
Patent DE-60316464-T2 (DE)
Inventor: KUFER PETER
IPC: C12Q1/68
Filed: 2003-11-28
Granted: 2008-06-26
Abstract: The present invention relates to a highly sensitive real-time RT-PCR method for specifically detecting the expression of more than one MAGE gene. The present invention further relates to a diagnostic composition for carrying out such a real-time RT-PCR as well as to oligonucleotides suitable for the cDNA synthesis reaction prior to real-time PCR amplification of more than one marker from the MAGE gene family. To enable the quantitative measurement of MAGE gene expression in a clinical sample an RT-protocol was invented using very sophisticated non-standard conditions to accomplish real-time PCR amplification of cDNA of several MAGE family members in relation to a comparative normalizing reference gene as internal control.
Patent DE-68901994-T2 (DE)
Inventor: ROBERTSON DAVID WAYNE
IPC: C07C311/00
Filed: 1989-04-06
Granted: 1993-02-25
Abstract: The present invention provides 3-(4-substitutedphenoxy)-3-phenyl propanamines capable of inhibiting the uptake of serotonin.
Patent DE-68903605-T2 (DE)
Inventor: FRANCE GORDON
IPC: A61K9/20
Filed: 1989-04-27
Granted: 1993-04-01
Abstract: A pharmaceutical chewable tablet composition comprising:     (i) granules containing a therapeutically active substance; and (ii) an extragranular water-insoluble hygroscopic excipient in an amount of 5% to 15% by weight of the total weight of the tablet. Particular therapeutically active substances include cimetidine and examples of suitable hygroscopic excipients include microcrystalline cellulose and powdered cellulose.
Patent DE-68908668-T2 (DE)
Inventor: DARRIN ALAIN
IPC: F16B7/00
Filed: 1989-11-14
Granted: 1993-12-23
Abstract: Process for connecting and assembling tubular elements, according to which the various tubes (1) are joined to one another by connectors or sleeves (2), the ends (10-3) of these two elements being fitted one inside the other and the bond being obtained by adhesive bonding. The process is distinguished by the fact that, after fitting the two members one inside the other and before the adhesive has set, an additional connector (4) is introduced inside one of the elements, one part (5) of the additional connector being pressed against the inside of the surface (8) of the element inside which it has been introduced, and the other part (6) of the additional connector being screwed inside the second element, the final setting of the adhesive taking place after installation of this additional joining element.
Patent DE-68926931-T2 (DE)
Inventor: MARULLO STEFANO
IPC: C12Q1/68
Filed: 1989-03-17
Granted: 1997-03-06
Abstract: The invention relates to a vector capable of being replicated in cultures of unicellular organisms, this vector containing a gene coding for a eukaryotic protein having the biological activity of a membrane receptor and interacting with a regulatory protein-called the G protein-able to bind molecules of guanosine triphosphate (GTP). The invention also relates to cell organisms transformed by the above vectors. It also relates to procedures for the detection of the capacity of a molecule to behave as a ligand for a receptor and a procedure for studying the affinity of a receptor for a ligand as well as a kit for detecting the possible affinity of a ligand for a receptor.
Patent DE-68927523-T2 (DE)
Inventor: MORRISON SHERIE L
IPC: A61K39/395
Filed: 1989-02-03
Granted: 1997-05-28
Abstract: An antibody having at least one binding site region and a domain-modified constant region is provided wherein the domain-modified constant region is a substitution, duplication, or deletion of substantially all of the amino acids of at least one of the domains of the constant region. The functional properties of the domain-modified constant region antibodies are altered to enhance the desired biological functions for a particular application. DNA sequences encoding constructs expressing domain-modified constant region antibody heavy chains and cells expressing domain-modified constant region antibodies are also provided.
Patent DE-68927636-T2 (DE)
Inventor: HERTEL LARRY WAYNE
IPC: C07D463/00
Filed: 1989-12-08
Granted: 1997-05-28
Abstract: A process for photochemically converting 3-exomethylene cephams (or 1-carba(1-dethia)cephams or 1-oxa(1-dethia)cephams) from the corresponding 3-alkyl-3-cephem (or 1-carba(1-dethia)cephem or 1-oxa(1-dethia)cephem) is provided. Further provided are 3-cephams useful as intermediates to 3-cephem compounds.
Patent DE-69011836-T2 (DE)
Inventor: KURAMOTO ROY
IPC: A61K47/32
Filed: 1990-12-21
Granted: 1995-03-09
Abstract: The preparation of pharmaceutical powder compositions which are directly compressible into tablets, is disclosed. The disclosed process includes subjecting an aqueous slurry/solution of a pharmaceutically active drug specifically naproxen or naproxen sodium (which slurry may be directly obtained without drying from the synthesis of the drug), alone or in admixture with an aqueous mixture of excipient materials, to a controlled form of spray drying to produce a dry powder of uniform particle size wherein the drug is uniformly dispersed in and coated with the excipients. The powder can be readily combined with additional dry excipient materials and formed into tablets. The process provides for substantial savings in the manufacture of the tablets. The spray dried powder compositions are highly compressible. Utilizing such spray dried powder compositions, the tablets formed are readily dissolvable and also are stable under normal storage conditions and stress conditions of temperature and relative humidity.
Patent DE-69019221-T2 (DE)
Inventor: ROWLAND RICHARD R
IPC: D06L3/06
Filed: 1990-03-19
Granted: 1995-09-07
Abstract: Polyglycolate compounds are provided having the general structure:   <CHEM> wherein n is an integer from 2 to about 10; R is C1-20 linear or branched alkyl, alkoxylated alkyl, cycloalkyl, aryl, alkylaryl, substituted aryl; R min  and R sec  are independently H, C1-20 alkyl, aryl, C1-20 alkylaryl, substituted aryl, and NR3< alpha +>, wherein R< alpha > is C1-30 alkyl; and L is a leaving group displaceable in a peroxygen bleaching solution by perhydroxide anion. When this compound is combined with a source of peroxygen in aqueous solution, then a plurality of stain removing peracids are formed. Such peracids are formed substantially sequentially beginning with the carbonyl adjacent to the leaving group L. Thus, a first stain removing peracid having the structure <CHEM> will be formed in amounts approaching quantitative yield. u
Patent DE-69020722-T2 (DE)
Inventor: OHSAKI MASUTAKA
IPC: C07K14/585
Filed: 1990-11-07
Granted: 1996-01-18
Abstract: Peptides of formula (I) and their acid addn. salts and complexes are new, where A is -SER(X')-ASN-LEU-SER(X')-THR(X')-OH, SER(X')-ASN-LEU-SER(X')-OH, SER(X')-ASN-LEU-OH, SER(X')-ASN-OH OR SER(X')-OH; B is X'', X''-THR(X'), X''-SER(X')-THR(X'), X''-LEU-SER(X')-THR(X') OR X''-ASN-LEU-SER(X')-THR(X'); X is OH, a carbonyl-protecting gp., an amino-acid residue or a peptide residue; X' is H or an OH-protecting gp.; X'' is H or an amino-protecting gp. Cyclisation of (I) by chemical condensation, e.g. by cyclisation in the presence of an alkali metal salt such as a Li, Na, K, Rb or Cs halide (0.01-400 equivs.) or in the presence of a solid-phase resin such as a benzhydrylamine, p-methylbenzhydrylamine or p-hydroxybenzoic acid resin (1-3 equivs. (I) per equiv. resin) gives a cyclic calcitonin deriv. of formula (II), where -D-E- is -SER-ASN-LEU-SER-THR-, X is OH, a carboxyl-protecting gp., amino-acid residue or peptide residue; and if in (I) the gps. A and B together complete the same chain as -D-E-. Pref. carboxyl-protecting gps. X are alkoxy, cycloalkoxy, (substd.) aralkoxy or (substd.) phenacyl; amino-acid residues X are -VAL-OH or -MET-OH; peptide residues X are -VAL-LEU-GLY-OH, etc. Pref. carboxy-protecting gps. X' are alkoxy, cycloalkoxy, (substd.) aralkoxy, (substd.) hydrazino or phenacyl. Pref. amino-protecting gps. X'' are (substd. alkoxycarbonyl, (substd.) aralkyl or (substd.) acyl, etc.
Patent DE-69105962-T2 (DE)
Inventor: TU XUAN MAI
IPC: G01R33/07
Filed: 1991-03-27
Granted: 1995-06-22
Abstract: PCT No. PCT/EP91/00617 Sec. 371 Date Sep. 25, 1992 Sec. 102(e) Date Sep. 25, 1992 PCT Filed Mar. 27, 1991 PCT Pub. No. WO91/15036 PCT Pub. Date Oct. 3, 1991.Apparatus and process for sorting used batteries and accumulators on the basis of their chemical constitution based on the analysis of the inductive effect produced by the substances which are contained in the battery or accumulator, and whose ferromagnetic properties differ according to their chemical constitution. The measurement process in which the apparatus is used is based on the consecutive application to the excitation circuit of at least two different voltage amplitudes at the same frequency or two different frequencies at the same voltage amplitude.
Patent DE-69109904-T2 (DE)
Inventor: MORRIS RICHARD LEO
IPC: C02F5/12
Filed: 1991-03-07
Granted: 1995-10-05
Abstract: A liquid membrane method for removing scale deposits wherein a chelating composition is utilized. The composition used in the external and internal aqueous phases of said membrane comprises an aqueous solution having a pH of about 8 to about 14, and a polyaminopolycarboxylic acid chelant. Additionally, a catalyst or synergist is used in the external phase only. Preferred chelants comprise diethylenetriaminepentaacetic acid (DTPA) or ethylenediaminetetraacetic acid (EDTA), salts, and mixture thereof. The catalyst used in the external phase comprises a monocarboxylic acid, preferably a substituted acetic acid such as mercaptoacetic acid, hydroxyacetic acid and aminoacetic acid or an aromatic acid such as salicylic acid. When the solution containing the composition is contacted with a surface containing a scale deposit, the deposit dissolves substantially more scale quicker than heretofore possible. <IMAGE>
Patent DE-69112409-T2 (DE)
Inventor: SMITH DAVID BALFOUR
IPC: E21B47/16
Filed: 1991-09-18
Granted: 1996-04-11
Abstract: Data is transmitted along a borehole containing a drill stem ( 2 ) by means of a transmitter ( 6 ) which converts electric data signals to acoustic signals propagating along the drill stem ( 2 ). The acoustic signals are converted back to electric form by a receiver ( 12 ) which also processes the signals. In the preferred form the signals are stored in a receiver memory ( 15 ) for subsequent retrieval using a pick-up tool ( 5 ) lowered into the borehole. The system is particularly useful in moving data past an obstruction such as a shut-in valve ( 4 ).
Patent DE-69118908-T2 (DE)
Inventor: ADLER PETER
IPC: B65D71/02
Filed: 1991-12-04
Granted: 1996-09-19
Abstract: PCT No. PCT/SE91/00825 Sec. 371 Date May 17, 1994 Sec. 102(e) Date May 17, 1994 PCT Filed Dec. 4, 1991 PCT Pub. No. WO92/10406 PCT Pub. Date Jun. 25, 1992.A box pallet having a base (1) and four sidewalls (2-5) is characterized in that the base (1) has four vertical walls (7-10) which, together with the upper surface (6) of the base, form an upwardly open, rectangular space for accommodating the sidewalls (2-5), each sidewall being releasably connected to the adjacent sidewall in that the vertical edge portions of the adjacent sidewalls are in the shape of hook-shaped beads (15, 16) engaging one another, and that the upper surface (6) and the vertical walls (7-10) of the base form supporting and guiding means for the sidewalls (2-5) resting loosely on the upper surface of the base.
Patent DE-69125890-T2 (DE)
Inventor: ELAD YIGAL
IPC: A01N63/38
Filed: 1991-07-10
Granted: 1997-08-21
Abstract: The present invention relates to a novel biologically pure culture of Trichoderma Harzianum, T-39, to biological control compositions containing same and to methods of protecting plants from the disease gray mold, caused by B. Cinerea and the disease white rot caused by S. Sclerotiorum with such compositions.
Patent DE-69126310-T2 (DE)
Inventor: SAVUSALO JARI
IPC: G01R29/10
Filed: 1991-07-24
Granted: 1997-10-30
Abstract: The invention relates to a method and a device for supervising the condition of a receiving antenna by transmitting a radio-frequency measuring signal through an antenna line (2) to the antenna and by measuring (8) the magnitude of a measuring signal component reflected back from the antenna. To improve the measuring accuracy, the invention is characterized in that the same measuring signal is measured also when transmitted directly in the direction of the receiver and the condition of the antenna (1) is determined on the basis of the relative difference between the two measured signal magnitudes.
Patent DE-69202392-T2 (DE)
Inventor: FIEBELKORN RICHARD THOMAS
IPC: A24D1/00
Filed: 1992-05-18
Granted: 1995-09-21
Abstract: The invention relates to low delivery cigarettes, usually having a mainstream particulate matter delivery of about 9mg or less. The cigarettes(1) comprise a rod (2) of tobacco material and a filter element (3). The filter element (3) comprises an alkali filter material section (4) having a loading level of less than 12% by weight of the section. The characteristics of the cigarettes (1) are arranged so that, when smoked, the alkaline filter material is exposed to an amount of smoke acceptable to achieve an increased perception of smoke impact. This is usually achieved by using a low particulate matter potential rod. In this way the moisture free dry particulate matter (NFDPM) to nicotine ratio is decreased compared with control cigarettes having the same cigarette characteristics without the addition of alkaline filter material to the filter element. <IMAGE>
Patent DE-69206075-T2 (DE)
Inventor: SHARP PHILLIP JOHN
IPC: C07K14/435
Filed: 1992-02-06
Granted: 1996-06-13
Abstract: Disclosed is a substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism infestation by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.
Patent DE-69224765-T2 (DE)
Inventor: HECK JAMES V
IPC: A61P31/04
Filed: 1992-04-03
Granted: 1998-10-15
Abstract: Compounds of the formula: <CHEM> where R is hydrogen, hydroxyl, alkyl or acyl, R min  and R sec together are oxo, hydroxyimino or alkoxyimino, and R min  and R sec independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.
Patent DE-69233446-T2 (DE)
Inventor: TORKINGTON JOHN ALEXANDER
IPC: C08K3/36
Filed: 1992-07-23
Granted: 2005-04-07
Abstract: An additive composition suitable for addition to polyolefins which comprises a synthetic silica as an antiblocking agent, a slip agent and an alkylene polyether is disclosed. The synthetic silica can be an amorphous aqueous precipitated silica or a fumed silica. The preferred alkylene polyether is polyethylene glycol and preferably has a molecular weight in the range 2,000-6,000. The alkylene polyether is preferably present in the composition in an amount from 200 to 1,500ppm. It is preferred to premix the alkylene polyether in the liquid state with the silica before adding to the composition. There is also disclosed an extrudable polymer composition comprising the additive composition and a film made from said extrudable polyolefin.
Patent DE-69233699-T2 (DE)
Inventor: OSHLACK BENJAMIN
IPC: A61K47/44
Filed: 1992-11-25
Granted: 2008-02-28
Abstract: (A) Controlled release oxycodone formulation for oral admin. to human patients, comprises (i) 10-40mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-60 ng/ml from a mean of 2-4.5 hrs.. After admin., and a mean min. plasma conc. of 3-30 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady state conditions. (ii) 10-160 mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin., and a mean min. plasma conc. from 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions. (B) Also claimed is a solid controlled release oral dosage form comprising (i) oxycodone or its salt in amt. of 10-160 mg; a controlled release matrix selected from hydrophilic hydrophobic polymers, digestible opt. substd. 8-50C hydrocarbons, and/or polyalkylene glycols; and a diluent; wherein the compsn. provides a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin, and mean min. plasma conc. of 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions; or (ii) an analgesically effective amt. of spheroids comprising oxycodone or its salt and either a spheronising agent or an acrylic polymer or copolymer, such that the total dosage of oxycodone in the dosage form is 10-160 mg; a film coating which controls the release of the oxycodone or its salt at a controlled rate in an aq. medium, wherein the compsn. provides an in vitro dissolution rate of the dosage form.
Patent DE-69302269-T2 (DE)
Inventor: ASKMAN LARS
IPC: A23L7/109
Filed: 1993-08-28
Granted: 1996-08-22
Abstract: A process for blanching or cooking a pasta strand which comprises feeding a pasta strand and hot water to the inlet of a pipe, conveying the pasta strand and hot water through the pipe for blanching or cooking the pasta strand, draining water from the blanched or cooked pasta strand as it exits from the pipe and recirculating the drained water to the inlet of the pipe. <IMAGE>
Patent DE-69313980-T2 (DE)
Inventor: PRONER ALAIN
IPC: B23K9/04
Filed: 1993-11-25
Granted: 1998-03-26
Abstract: The invention relates to a method for the build-up of a workpiece by means of a transferred-arc plasma device. According to this method, there is deposited onto the workpiece (1) to be built up at least one weld bead (7a, 7b, 7c) of the said material solely by means of the transferred-arc plasma device (5), by moving the plasma device with respect to the workpiece at a speed of 1.5 to 50 m/min and by using a power of the plasma device such that the surface of the workpiece is melted to a depth at least equal to 0.5 mm and such that the coarsening of the grains in the molten zone does not exceed 10 %, without cooling the workpiece during the build-up. <IMAGE>
Patent DE-69314266-T2 (DE)
Inventor: LUI CHUN KEE
IPC: A61M25/00
Filed: 1993-07-13
Granted: 1998-01-22
Abstract: A valved catheter comprising an elongated tubular member (11) with a longitudinal passage (14) extending therethrough to a lateral facing valve (12) in the region of the distal end of the catheter, the tubular member in the said region of the distal end is of reduced cross-section and has a planar surface (21), and in that the valve (20) is formed in the said planar surface. <IMAGE>