baber/WOPTO huggingface dataset:
Patent NZ-514661-A (NZ)
Title: alpha-substituted carboxylic acid derivatives and their use as therapeutic agents in pharmaceutical compositions
Inventor: FUJITA TAKASHI
IPC: C07D235/06
Filed: 2000-04-06
Abstract: The a-substituted carboxylic acid derivatives of formula (II), pharmacologically acceptable salts thereof, pharmacologically acceptable esters thereof or pharmacologically acceptable amides thereof are disclosed, wherein: A is N or a =CH- group; B is O or S; W1 is a C1-C8alkylene group; W2 is a single bond or a C1-C8alkylene group; Y is O or S(O)p group, wherein p is 0 to 2; R1, R2, R3 X and Z2 are as described in the specification. a-substituted carboxylic acid derivatives of formula (II) exhibit the activity such as insulin resistance improving activity, hypoglycemic activity, anti-inflammatory activity, immunoregulatory activity, and are useful as therapeutic agents and/or preventive agents for diabetes mellitus, glucose tolerance insufficiency, gestational diabetes mellitus, or the like.
Patent NZ-514788-A (NZ)
Title: Crystalline forms of the sodium salt of 5- chloro -2- methoxy -N- (2- (4-methoxy -3- methyl aminothio carbonylamino sulfonylphenyl) ethyl) benzamide
Inventor: ENGLERT HEINRICH CHRISTIAN
IPC: A61P9/06
Filed: 2000-04-04
Abstract: Crystalline  forms of the sodium salt  of  5-chloro-2- methoxy-N-(2-(4-methoxy-3-methyl-aminothiocarbonyl- aminosulphonylphenyl)ethyl)-benzamide are described. The  compounds  are used for the therapy or  prophylaxis  of cardiac  arrhythmias, ischemic conditions of  the  heart  or weakened  myocardial contractile force or for the prevention of sudden cardiac death.
Patent NZ-515607-A (NZ)
Title: Method of sterilizing
Inventor: PRUSINER STANLEY B
IPC: A61P31/04
Filed: 2000-05-24
Abstract: A method of sterilising objects as well as the sterilised objects obtained from the method is disclosed. The method involves contacting an object such as a medical device to be reused with polycationic dendrimer under conditions which result in rendering a conformationally altered protein (e.g. a prion) non-infectious. A disinfecting agent or surgical scrub composition which comprises the dendrimers is also disclosed as are gelatin capsules treated with polycationic dendrimers.
Patent NZ-517028-A (NZ)
Title: Manufacturer of a whey protein with an enriched alpha-lactalbumin fraction performed without using heat
Inventor: WU CHAO
IPC: A23C9/142
Filed: 2000-07-13
Abstract: A method of making an á-lactalbumin enriched whey protein product is described.  The method involves the treatment of a whey protein product with an acid to lower the pH of the whey protein product to 4.0 or below.  This pH-lowering step allows the á-lactalbumin molecules to be concentrated more efficiently
Patent NZ-518298-A (NZ)
Title: Ciclesonide contained pharmaceutical composition for application to mucosa
Inventor: NAGANO ATSUHIRO
IPC: A61K31/58
Filed: 2000-10-20
Abstract: An aqueous pharmaceutical composition for application to the mucosa, such as the nasal mucosa. The composition comprises ciclesonide and one or more water-insoluble and or water-low soluble substance (such as cellulose). The composition has an osmotic pressure of less than 290 mOsm. The composition may also have the following excipients: - An osmotic pressure-controlling agent, such as sodium chloride or a water soluble sugar such as glucose. - A water soluble polymer substance such as alginic acid, propylene glycol, pectin, guar gum and hydroxypropyl cellulose. - A surfactant such as polysorbate 80.
Patent NZ-518608-A (NZ)
Title: Local prevention or amelioration of pain from surgically closed wounds
Inventor: CASSEL DOUGLAS R
IPC: A61P25/04
Filed: 2000-10-18
Abstract: A non-invasive and non-systemic method for intradermal prevention or amelioration of pain from a surgically closed wound is disclosed. The method comprises topical delivery of a local anesthetic to an exterior to an exterior surface of a surgically closed wound.
Patent NZ-523900-A (NZ)
Title: Isolation and characterisation of a mannan-binding lectin (MBL) associated serine protease (MASP-2) and uses thereof to treat infections
Inventor: JENSENIUS JENS CHRISTIAN
IPC: A61K48/00
Filed: 2001-07-13
Abstract: A mannin-binding lectin associated serine protease-2 (MASP-2) polypeptides and fragments thereof as well as nucleic acids encoding such polypeptides are described. Furthermore, described are the uses of a the polypeptide comprising amino acid sequences derived from mannan-binding lectin associated serine protease-2 (MASP2) or a functional homologue thereof for the production of a pharmaceutical composition as well as pharmaceutical compositions comprising MASP-2 and/or MASP-2 fragments. In addition, inhibitors of MASP-2 and pharmaceutical composition comprising such inhibitors and methods for detecting MASP-2 nucleic acid expression are included in the specification.
Patent NZ-524717-A (NZ)
Title: Quinolinone derivatives
Inventor: RENHOWE PAUL
IPC: A61K31/19
Filed: 2001-09-11
Abstract: A compound having the structure I, a tautomer, a pharmaceutically acceptable salt; a pharmaceutical formulation comprising the compound; and the use of the compound in the preparation of a pharmaceutical formulation for use in treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase or cancer.
Patent NZ-528381-A (NZ)
Title: Method for converting natural gas to liquid hydrocarbons
Inventor: HALL KENNETH R
IPC: C07C2/76
Filed: 2002-03-07
Abstract: A process for converting natural gas to a liquid hydrocarbon is disclosed, which includes heating the gas to a selected range of temperature to convert a fraction of the gas stream to reactive hydrocarbons, primarily ethylene or acetylene, and reacting methane and the reactive hydrocarbons in the presence of an acidic catalyst to produce a liquid, predominantly naphtha or gasoline. A portion of the incoming natural gas may be used to heat the remainder of the natural gas to the selected range of temperature. Hydrogen resulting from the reactions may be used to make electricity in a fuel cell. Alternatively, hydrogen may be burned to heat the natural gas to the selected range of temperature.
Patent NZ-529662-A (NZ)
Title: Antibacterial agents that bind to EF-Tu used to inhibit cytoskeleton formation in bacterial cells
Inventor: MAYER FRANK
IPC: G01N33/50
Filed: 2002-04-22
Abstract: Described is the use of substances, binding to the bacterial translation factor EF-Tu, to prevent the formation of a cytoskeleton in bacterial cells and for production of anti-bacterial agents. Further described are anti-bacterial agents, comprising partial sections of the amino acid sequences of the domains 2 and/or 3 of a bacterial EF-Tu protein, preferably with a length of 4-20 amino acids.
Patent NZ-533420-A (NZ)
Title: Powdery drinks and process for producing the same
Inventor: INOUE TAKASHI
IPC: A23C1/14
Filed: 2002-12-17
Abstract: It is intended to provide a process for producing a powdery drink characterized by comprising electrolyzing a liquid food and/or conducting electricity through it and then drying and powdering the thus obtained liquid optionally followed by granulation. As the liquid food, use may be made of coffee extracts, coffee concentrates, milk, pre-treated milk and so on. Instant coffees and powdery milks obtained by the process can be stored over a prolonged period of time while preventing the flavor and qualities from deterioration without resort to any additives.
Patent NZ-534834-A (NZ)
Title: New inhibitors of histone deacetylase
Inventor: ROUX BRUNO
IPC: A61K31/497
Filed: 2003-03-11
Abstract: Disclosed are compounds of the formula (I): the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1, 2 or 3 and when n is 0 then a direct bond is intended; t is 0, 1, 2, 3 or 4 and when t is 0 then a direct bond is intended; each Q, X and Y is N or C where C singly bonded to two other atoms and doubly bonded to a third atom; each Z is N or CH where C is singly bonded to three other atoms R1 is -C(O)NH(OH); R2 is H, halo, hydroxy, amino, nitro, C1-6alkyl, C1-6alkoxy, trifluoromethyl, di(C1-6alkyl)amino, hydroxyamino or naphtalenylsulfonylpyrazinyl; -L- is a direct bond or a bivalent radical selected from C1-6alkanediyl, C1-6alkanediyloxy, amino, carbonyl or aminocarbonyl; each R3 independently represents a hydrogen atom and one hydrogen atom can be replaced by an aryl group; R4 is H, hydroxy, amino, hydroxyC1-6alkyl, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl aminocarbonyl, hydroxycarbonyl, aminoC1-6alkyl, aminocarbonylC1-6alkyl, hydroxycarbonylC1-6alkyl, hydroxyaminocarbonyl, C1-6alkyloxycarbonyl, C1- 6alkylaminocarbonyl, C1-6alkylaminoC1-6alkyl or di(C1-6alkyl)aminoC1-6alkyl. Further disclosed is the use of the compounds of the formula (I) in the preparation of a medicament for the treatment of proliferative diseases.
Patent NZ-537205-A (NZ)
Title: Severable carton wall
Inventor: BATES AARON
IPC: B65D5/54
Filed: 2003-06-16
Abstract: A severable carton wall includes a composite wall formed from a pair of panels (50, 52) joined along a seam (58), and a frangible line extending across the composite wall, traversing the seam, defining a line of severance. A segment of the frangible line that traverses the seam is an extensively weakened segment. The extensively-weakened segment is formed by terminal cut lines (70, 72) formed respectively in the panels (50, 52) that overlap to form the seam. The cut lines (70, 72) are disposed adjacent respective end edges (54, 56) of the panels.
Patent NZ-554208-A (NZ)
Title: Methods and compositions for fining beverages
Inventor: DUAN WEIDONG
IPC: A23L29/20
Filed: 2005-09-20
Abstract: Disclosed is a finings formulation capable of fining beer, the formulation comprising a pectin and a donor of sulphur dioxide, the pectin being selected from the group consisting of a high methyl ester pectin with a degree of esterification of 50-70%, a low methyl ester pectin with a degree of esterification of 20-50%, an amidated low methyl ester pectin with a degree of esterification of 20-40%, or a pectin selected from the pectins listed in Table 1.
Patent NZ-555030-A (NZ)
Title: Scraper For Cleaning Tubular Members
Inventor: SOTIRAKOS BILL
IPC: B08B1/00
Filed: 2005-11-29
Abstract: A scraper for the removal of deposits from the exterior of a tubular member comprising: (a) first and second co-aligned, spaced apart annular disks 10; (b) a plurality of spacers 40 positioned about the periphery of an inner surface of each the first and second annular disk; and (c)a scraper cartridge 30 positioned co-alignment between the first and second annular disks 10 and comprising a plurality of resilient wire assemblies positioned to define an opening having a diameter less than the external diameter of the tubular member, the plurality of wire assemblies each consisting of a resilient wire having at least three integral, concatenated, resilient segments defined by a geniculation between two adjacent segments, whereby at least one of the segments is aligned the cartridge 30 to deformingly contact an exterior surface of tubular member positioned through the opening.
Patent NZ-564258-A (NZ)
Title: Azaindazole compounds and methods of use
Inventor: ZHANG PENGLIE
IPC: A61K31/496
Filed: 2006-06-22
Abstract: Disclosed are azaindazole compounds and are represented by the formulas Ia and Ib. The compounds feature a pyrazole fused with a nitrogen containing heterocycle and an optionally substituted piperazinyl ring. The substituents are as disclosed in the description. Also disclosed is a pharmaceutical composition containing a compound of formula Ia or Ib and the use of a compound of formula Ia or Ib in the manufacture of a medicament for treating CCR 1 mediated disease especially inflammatory conditions and immunoregulatory disorders such as rheumatoid arthritis, multiple sclerosis, transplant rejection, restenosis, dermatitis, eczema, urticaria, vasculitis, inflammatory bowel disease, food allergy, asthma, Alzheimer's disease, Parkinson's disease, psoriasis, lupus erythematosus, osteoarthritis, stroke, and encephalomyelitis.
Patent NZ-577012-A (NZ)
Title: Human zymogen granule protein 16 as a marker for detection of gastric cancer
Inventor: GUILFORD PARRY JOHN
IPC: C12Q1/68
Filed: 2010-05-14
Abstract: Disclosed is a method for detecting gastric cancer, comprising: (i) providing a biological sample; and (ii) detecting the levels of human zymogen granule protein 16 (ZG16) in said sample, wherein the overexpression of ZG16 in the biological sample is indicative 5 of cancer.
Patent NZ-579535-A (NZ)
Title: Mg-BASED ALLOY PLATED STEEL MATERIAL
Inventor: TOKUDA KOHEI
IPC: C23C2/04
Filed: 2008-03-14
Abstract: Disclosed herein are Mg-based alloy plated steel material characterized by being provided with a hot dip Mg-based alloy plating layer containing Zn: 15 atm% or more and Mg: over 35 to 85 atm%, in particular 55-85atm%, and further containing one or more elements selected from the group of elements B: Al, Ca, Y, and La in a total of 0.03 to 15 atm%.
Patent NZ-583147-A (NZ)
Title: Dehydroepiandrosterone compositions for treating menopause
Inventor: LABRIE FERNAND
IPC: A61P15/12
Filed: 2008-08-08
Abstract: Disclosed is the use of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androst-5-ene-3beta,17beta-diol, and 4-androsten-3,17-dione, optionally combined with a Selective Estrogen Receptor Modulator (Acolbifene), in the manufacture of a medicament for treating or reducing the likelihood of acquiring vaginal diseases or problems selected from urinary incontinence, vaginal atrophy, atrophic vaginitis, vaginal dryness, dyspareunia and sexual dysfunction in postmenopausal women, wherein said medicament is formulated for intravaginal administration of said sex steroid precursor at a therapeutic amount of 13 mg per day or less. Further disclosed is a pharmaceutical composition for intravaginal administration comprising a sex steroid precursor selected from dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androst-5-ene-3beta,17beta-diol, and 4-androsten-3,17-dione and further comprising a pharmaceutically acceptable excipient, diluent or carrier. Also disclosed is a vaginal suppository comprising dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androst-5-ene-3beta,17beta-diol, and 4-androsten-3,17-dione and an excipient comprising saturated fatty acid asters or Witepsol H-15.
Patent NZ-591953-A (NZ)
Title: Drive shaft assembly for a garden tool with a shaft having a pin and flange to engage a socket of another shaft
Inventor: NORTON CARL
IPC: F16B7/20
Filed: 2009-09-03
Abstract: A drive shaft assembly intended to extend between an internal combustion engine and a garden tool such as a line trimmer or edge cutter. The assembly (10) includes a first shaft (11) which is rotatably supported in a first tubular member (13). The first shaft has a first end portion (15) which has a socket (16) with a slot (21) and has guide surfaces (19, 20) converging to the slot. The assembly further has a second shaft (12) which is rotatably supported in a second tubular member (14) and is engaged coaxially with the first shaft. The second shaft has an end portion (26) which engages with the slot of the first shaft member and has a flange (27) which is guided by the guide surfaces. The tubular members enclose the end parts of the shafts when the shafts are coupled.
Patent NZ-597337-A (NZ)
Title: Rubbish receptacle with removable flexible insert and vents
Inventor: HOLT BRUCE KENNETH
IPC: B65F1/06
Filed: 2011-12-22
Abstract: A rigid plastic rubbish or kitchen waste container bin shaped with a taper, with a plastic bag fitted inside in an open position to accept objects placed in the container, the container bin has at least one vent to allow air trapped between the outer surface of the bag and the inner surface of the container to escape to outside the container, each vent has four aligned u-shaped notches or grooves with rounded edges to reduce the frequency of bag tearing on the upper edge of the notch. A bag holder retains the top edge of the bag over the upper edge of the container. Each notch is constantly sized to allow smooth air flow and each notch is reinforced with ribs or webs to maintain structural integrity.
Patent NZ-598848-A (NZ)
Title: Macro-control of treatment for sleep disordered breathing
Inventor: BERTHON-JONES MICHAEL
IPC: A61B5/08
Filed: 2004-11-25
Abstract: A method of operating a respiratory apparatus comprises receiving a respiratory air flow signal; detecting sleep disordered breathing (SOS) based on the respiratory air flow signal; determining a pressure change in response to the SOS detection; determining a measure of sleep arousal based on the respiratory air flow signal; and determining an adjustment of aggressiveness of the pressure change based on the measure of sleep arousal.
Patent NZ-602320-A (NZ)
Title: Bispecific, bivalent anti-vegf/anti-ang-2 antibodies
Inventor: BAEHNER MONIKA
IPC: C07K16/22
Filed: 2011-03-24
Abstract: 602320 Disclosed is a bispecific, bivalent antibody comprising a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, characterized in that i) said first antigen-binding site comprises as heavy chain variable domain (VH) the SEQ ID NO: 1, and as light chain variable domain (VL) the SEQ ID NO: 2; and ii) said second antigen-binding site comprises as heavy chain variable domain (VH) the SEQ ID NO: 3, and as light chain variable domain (VL) the SEQ ID NO: 4; and further characterized in comprising a) the heavy chain and the light chain of a first full length antibody that specifically binds to VEGF; b) the modified heavy chain and modified light chain of a full length antibody that specifically binds to ANG-2, wherein the constant domains CL and CH1 are replaced by each other.
Patent NZ-602870-A (NZ)
Title: Method for generating and rebuilding a stereoscopic-compatible video stream and related coding and decoding devices
Inventor: D’AMATO PAOLO
IPC: H04N13/00
Filed: 2011-04-07
Abstract: Disclosed is a method for generating a digital stereoscopic video stream (101) comprising container frames (C). The container frames (C) comprise information about a right image (R) and a left image (L). The method includes, when coding the digital stereoscopic video stream (101), entering into the video stream at least one metadatum (M) which is adapted to identify a region of a container frame (C) containing only one of the two images (L,R). The metadatum (M) may conform to the H.264/AVC standard and define a cropping rectangle according to this standard except that the cropping rectangle may be defined such that it delimits a single image of the stereoscopic container frame. The cropping rectangle may then be used to generate a 2D video stream from the 3D stereoscopic video stream. The metadatum (M) may be ignored in order to reproduce the 3D stereoscopic video stream.
Patent NZ-603698-A (NZ)
Title: Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
Inventor: GHAYUR TARIQ
IPC: A61K39/00
Filed: 2009-07-08
Abstract: 603698 Disclosed is a binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; XI1is a linker; X2 is an Fc region; and n is 0 or 1; wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site; and wherein the binding protein is capable of binding TNF and PGE2, wherein: (a) the variable domains that form a functional binding site for TNF comprise EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSS and DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIKR; and (b) the variable domains that form a functional binding site for PGE2 comprise EVQLVQSGAEVKKPGASVKVSCKASGYTFTKYWLGWVRQAPGQGLEWMGDIYPGYDYTHYNEKFKDRVTLTTDTSTSTAYMELRSLRSDDTAVYYCARSDGSSTYWGQGTLVTVSS and DVLMTQTPLSLPVTPGEPASISCTSSQNRleVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQVSHVPYTFGGGTKVEIKR
Patent NZ-611148-A (NZ)
Title: Formulations comprising polyethylene glycol
Inventor: COX IAN
IPC: A61P1/10
Filed: 2011-11-04
Abstract: Disclosed is a solid formulation for oral administration as a solid, comprising: (a) 50-90% w/w polyethylene glycol (PEG) having an average molecular weight within the range 2,000 to 10,000 Da; and (b) 10-40 % w/w of a solid selected from the group consisting of sorbitol, lactose, dextrates, cellulose, xylitol, maltitol and mannitol. Also disclosed is a chewable or suckable solid formulation for oral administration as a solid for maintaining gastro-intestinal health and for preventing gastro-intestinal disorders, comprising: (a) 2.0 to 3.5g PEG having an average molecular weight of 3000 to 4000 Da; (b) 250 to 500mg of a solid selected from the group consisting of: sorbitol, lactose, dextrates, cellulose, xylitol, maltitol, and mannitol. Also disclosed is the use of a formulation as defined above, in the manufacture of a medicament for preventing dehydration of the stool, softening the stool for ease of defecation, preventing constipation, allowing regular gastrointestinal transit.
Patent NZ-624532-A (NZ)
Title: Low extract component, beer-taste beverage having adjusted ph
Inventor: TERANISHI TAKESHI
IPC: A23L2/38
Filed: 2012-11-19
Abstract: Discloses a non-alcohol, beer-taste beverage whose total amount of an extract component(s) is 0.3% by weight or lower, having a pH of 3.0 or higher and 4.5 or lower.
Patent NZ-708508-A (NZ)
Title: Methods of treatment using selective bcl-2 inhibitors
Inventor: GHAYUR TARIQ
IPC: A61P37/00
Filed: 2011-11-22
Abstract: Disclosed are the use of compounds that selectively inhibit the activity of Bcl-2 proteins for the treatment of systemic lupus erythematosus, lupus nephritis or Sjogren’s Syndrome. These inhibitors may have a structure of formula (I), wherein, A1, B1, Y1, R3, R5, R6, m and p are disclosed in the specification. These compounds may also have a binding affinity for Bcl- 2 that is less than the binding affinity for Bcl-xL. Example compounds include: 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohexl-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide; trans-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-methoxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide.
Patent NZ-712513-A (NZ)
Title: Espresso milk frother
Inventor: PURTON WILLIAM WESTMORE
IPC: A47J31/44
Filed: 2014-04-10
Abstract: A milk frothing apparatus which includes a steam probe; a jug and jug support; a sensor to determine the depth of milk in a jug. The steam probe or jug support is movable preferably driven by stepper motor, to maintain the tip of the probe below the milk surface. A temperature sensor monitors the temperature of the milk in the jug. A micro controller is programmable to start the process; maintain the position of the steam probe relative to the milk surface, stop the process when the milk reaches a desired temperature and maintain records of the number of cycles and a measure of the quantity of milk treated. By using a sensor to measure the distance to the milk surface in a jug the tip of the steam probe can be maintained at the appropriate distance below the milk surface by moving the jug relative to the probe or preferably moving the probe. The process can be more precisely controlled by sensing the milk temperature and ensuring that the process is completed before the milk becomes too hot. The units may use steam generated in the espresso machine or use a designated steam boiler. The units may have multiple stations each with a jug and steam probe and associated temperature sensor. The stations may have the provision of a locking mechanism to prevent removal of the jug while the process is in progress.