baber/WOPTO huggingface dataset:
Patent JP-2001505461-A (JP)
Title: 錠剤投与装置
IPC: B01F5/00
Filed: 1997-11-20
Abstract: (57)【要約】
本発明は、液体浸透性の錠剤投与装置（１０）に関する。本装置（１０）は、第１部材（１１）、反対側の第２部材（１４）及び接続手段（１２）を備えている。第１部材（１１）と第２部材（１４）とは、実質的に剛直である。第１部材（１１）及び第２部材（１４）は接続手段（１２）に接続されており、接続手段（１２）は柔軟で、第１部材（１１）と第２部材（１４）との間の距離は可変であり、第１部材と第２部材（１１、１４）とがきわめて近接することが可能である。第１部材（１１）及び第２部材（１４）は、投与装置（１０）が洗濯機内に載置される時、互いに対して実質的に自由な態様で移動可能である。
Patent JP-H09511178-A (JP)
IPC: B01D50/00
Filed: 1995-03-23
Abstract: A high capacity marine separator (30) is disclosed which uses a first stage formed by an inertial vane separator (32), a second stage formed by a coalescer stage (36) and a third stage formed by an inertial vane separator (34). The coalescer stage (36) is canted from vertical relative to the air flow direction which increases the surface area for air flow, increases the drainage rate of water from the coalescer section and provides an improved air flow distribution to the second inertial vane separator with higher velocities near the top of the second inertial vane separator. The inertial vane separators (32, 34) have flush cavities to reduce obstruction to air flow and have vanes that are greater than three inches in wavelength and spaced greater than one inch apart. The marine separator is capable of flow velocities of 50 standard feet per second.
Patent JP-H11510395-A (JP)
Title: アブシジア  リパーゼ活性を有するポリペプチドをコードする核酸
IPC: C12N9/20
Filed: 1997-01-21
Abstract: (57)【要約】
本発明は、アブシジア  リパーゼ活性を有するポリペプチドをコードする単離された核酸配列に関する。本発明はまた、核酸構造体、ベクター、及び前記核酸配列を含んで成る宿主細胞、並びに前記ポリペプチドを生成するための方法にも関する。本発明はさらに、前記ポリペプチドを含んで成る組成物にも関する。
Patent JP-H10504219-A (JP)
Title: 内視鏡外科用の外科器具を案内する装置
IPC: A61B90/50
Filed: 1996-03-08
Abstract: (57)【要約】
本発明は、内視鏡外科用器具を案内する装置に関する。これら外科用器具は、シャンク１０に取付けられる。シャンク１０は、不変点１で旋回可能であり、トロカール３０を介して体腔内へ、例えば手術のために挿入される。シャンク１０の端部に取り付けられた効果器１５は、体腔内で移動する一方、不変点１を、あらゆる空間的自由度で維持する。効果器１５は、不変点を通る第１軸線を中心とする円形回動運動で、シャンク１０と一緒に、剛体のように運動する。これにより、運動中、その端部は、軸線Ｉに対し常に同じ位置で運動する。更に、シャンク１０を有する効果器１５は、第２軸線ＩＩを中心として旋回できる。第２軸線ＩＩは、第１軸線Ｉに対し直角であり、第１軸線と不変点で交差し、一緒に回動する。
Patent JP-H11503426-A (JP)
IPC: A61K38/00
Filed: 1996-04-05
Abstract: A pharmaceutical composition for stimulating the haematopoietic function and preventing the myelotoxic side-effects of some treatments, containing at least one water-soluble muramyl peptide derivative such as Muradimetide, muroctasine or MTP-PE.
Patent JP-H09506330-A (JP)
Title: セラミックス及び高融点合金部材の複合化方法及び組成物
IPC: B23K35/28
Filed: 1995-05-22
Abstract: (57)【要約】
封着組成物は、溶剤に溶解した有機バインダーと無機バインダーとからなるビヒクルに分散される、重量比で、７０〜９０％のアルミニウム、５〜２５％のケイ素、０〜５％のシリカ及び０．１〜５％の調整金属からなる粉末を含有する。セラミックス部材と高融点合金又は超合金部材の複合化すべき面に被覆してから、全体を加熱して、上記ビヒクルを除去し、そして両部材間にセラミックスと同時結晶化したムライトの層を生成する。
Patent JP-2000508460-A (JP)
Title: 注目関連画像セクションの幾何学的データを求める方法
IPC: G06T5/20
Filed: 1997-12-18
Abstract: (57)【要約】
原画の注目関連画像セクションの、位置、寸法及び角度位置のような幾何学的データを自動的に求める方法が提示される。前記原画は、スキャナタブレットないしスキャナドラム上に取り付けられる。このためにスキャンされた原画のスキャンデータから明度像ないし明度画像が取得され、分析される。デジタルエッジフィルタリングにより、主に、水平及び垂直エッジが強調される。フィルタリングされた明度像ないし明度画像から、注目関連した画像セクションに対して適合された直線が求められ、この適合された直線から原画の注目関連した画像セクションが求められる。
Patent JP-H11503031-A (JP)
Title: 十分量の高温油で揚げた食品から脂肪を除去する方法
IPC: A23L5/20
Filed: 1997-02-24
Abstract: (57)【要約】
十分量の高温油で揚げた食品から脂肪を除去する方法及び装置を記載する。本発明の方法は無水エタノールを用いて実施するのが好ましい。本発明の方法はいわゆるスナック製品、例えばポテトチップに特に適当である。
Patent JP-2001521366-A (JP)
Title: タンパク質の豊富な食事用アイスクリーム
IPC: A23G9/44
Filed: 1997-03-05
Abstract: (57)【要約】
タンパク質の豊富な食事用アイスクリームのための成分が示唆され、それは、ブルガリア天然ヨーグルトに基づく一連のアイスクリームを製造するために用いられうるものであり、家庭で、並びに食品プラントおよび公の食事の場所で連続的に製造されうる。アイスクリームの内容は、タンパク質、ビタミン、鉱物塩などについてバランスが取れており、脂肪含有量は最小化されている。その食事用アイスクリームは、抗アテローム形成効果を含むその医療的および食事としての特性が明らかとなっている天然ブルガリアヨーグルトの乳製品ベースを含む。サレップ（オルキス・マスキュラＬ．の塊茎）加水分解物またはアルタエア・オフィシナリスＬ．の根の加水分解物が安定化剤および乳化剤として調理法において用いられる。ハッポファエ・ラムノイデスＬ．の油または油の抽出物およびビスクム・アルブムＬ．の薬剤の加水分解物の添加は、ビタミン、ミクロおよびマクロ要素のバランスを改善し、アイスクリームのシリーズの内容物の医療上および予防上の作用を限定する。果実、野菜または果実と野菜の塊は、充填物として、成分として含まれうる。
Patent JP-2001511012-A (JP)
Title: 腫瘍崩壊性／免疫原性相補アデノウイルスベクター系
IPC: A61K35/76
Filed: 1998-01-23
Abstract: (57)【要約】
本発明は、腫瘍細胞のような標的細胞を殺すための組成物を包含する。組成物は、相補的機能を示し、そして標的細胞中での複製に互いに依存しあう第一および第二のアデノウイルスベクターを含む。上記アデノウイルスベクターの内の１つは、直接的にまたは間接的に標的細胞を殺す標的細胞中のアデノウイルスベクターの増殖を制御および制限する標的細胞活性化プロモーターまたは機能欠失を有する。アデノウイルスベクターの内の１つは、標的細胞中で発現され、そして抗癌免疫応答を誘導できるタンパク質をコードする遺伝子を包含する。標的細胞は、例えば、肝癌、乳癌、黒色腫、結腸癌または前立腺癌細胞でありうる。本発明のベクターは、標的細胞が、例えば血管の平滑筋細胞でありうる場合に、再狭窄のような他の疾患を治療するのに活用することもできうる。
Patent JP-2000514256-A (JP)
Title: レンジ拡張用コレクタアレイを用いるｔｄｍａ無線通信のための方法および装置
IPC: H04B7/02
Filed: 1997-04-16
Abstract: (57)【要約】
ＴＤＭＡ通信システムは、放送装置によって確立される任意に大きい放送装置帯域において、移動ユーザと帯域マネージャとの間の順方向チャネル通信および対応する逆方向チャネル通信を有する。ユーザは、放送装置帯域内に配置される。コレクタは、放送装置帯域に近接して配分される。帯域マネージャは、ユーザグループを形成するためにユーザの選択を制御し、コレクタグループを形成するためにコレクタを選択するように操作し、且つ、同一コレクタに対してアクティブであるユーザの間において、コレクタにおけるユーザ逆方向チャネル信号が相互に分離されるように放送装置からユーザを経てコレクタまでの伝播時間の差が同期化エラーを超過しないように、コレクタグループを形成する様にコレクタを選択する。ユーザグループ内の各ユーザが、当該ユーザグループ内の前記の他のユーザの各々からの、距離ＵＲmaxよりも大きいくない距離に位置するように、ユーザが選定される。１つのコレクタグループに属するコレクタの各々が、距離ＣＲmaxよりも大きくないような前記コレクタグループに属する他のコレクタの各々からの距離に位置するようにコレクタが選定される。ここに、ＣＲmaxは、コレクタにおけるユーザ逆方向チャネル信号が分離されるような値である。
Patent JP-2000510805-A (JP)
Title: 粉体サスペンションの選択的ゲル化によるプリフォームの製造方法
IPC: C04B35/632
Filed: 1997-05-09
Abstract: (57)【要約】
本発明は、新規なフリーフォーム製造方法である。すなわち、本固体フリーフォーム製造方法は、（ａ）粉末粒子をサスペンション溶媒及びゲル化多糖類と混合することによってスラリを調製する工程と、（ｂ）ある量の前記粉体スラリを限定された領域に堆積させることによって、層を形成する工程と、（ｃ）前記層の選択された部分にゲル化剤を付与することによって、前記層の前記選択された部分を硬化させる工程と、（ｄ）前記工程（ｂ）及び（ｃ）を繰り返して一連の層を形成して、層状物体を形成する工程とを備えている。多くの用途において、硬化されていない材料を除去し、その後、加熱してゲル化する多糖類を除去し、次に、焼結を行うことが望ましい。
Patent JP-2000511891-A (JP)
Title: チオシアナト―トリアゾリル誘導体及びその殺微生物剤としての使用
IPC: C07D249/12
Filed: 1997-05-09
Abstract: (57)【要約】
 本発明はＲ 1 が本明細書に記載の意味を有する式（Ｉ）の新規なチオシアナト−トリアゾリル誘導体、並びにその酸付加塩及び金属塩錯体に関する。更に該新規物質の製造方法並びに植物及び材料保護を目的とする殺微生物剤としてのその使用に関する。
Patent MD-20000120-A (MD)
Title: Laser semiconductor diode integrated with frequency doubler
Inventor: TIGHINEANU ION
Filed: 2000-07-17
Abstract: he invention relates to the technology of semiconductor devices and may be used in the production field of laser semiconductor diodes integrated with non-linear optical elements. The invention consists in the elaboration of a structure of laser diode integrated into a single crystal with a non-linear optical element in the capacity of frequency doubler.The problem that the present invention solves consists in that the non-linear optical element is formed in the waveguide of the laser diode by creating a nanostructurized zone, which provides for the fulfillment of the phase synchronism condition.The result of the invention consists in the manufacture of laser semiconductor structures integrated into a single crystal with frequency doubler by creation in the laser diode waveguide of a nanostructurized zone with optical anisotropic properties, oriented at an angle providing for the fulfillment of the phase synchronism conditions.Claims: 1Fig.: 1
Patent NZ-215657-A (NZ)
Title: Suspension insulator: corrosion protection shield between cap and dielectric skirt
Inventor: DEDECKER D
IPC: H01B17/42
Filed: 1986-04-02
Abstract: An electrical insulator (1) of the type comprising at least one dielectric (2) and an iron or steel cap (3) fixed axially on the dielectric has a device for protecting the cap against corrosion as well as electric arcs. In one embodiment (FIGS. 1-3), the protection device comprises a zinc or aluminum part (10) shaped as a dish with a center hole (11) and outlet holes (12) for the egress of rainwater. The outside wall (13) of the part (10) curves upwardly toward the cap (3) and a portion of the part (10) is disposed between the base (6) of the cap (3) and the outer surface (7) of the dielectric (2). In another embodiment (FIG. 4), the protection device comprises a solid body of revolution (30) of semi-toroidal shape which is formed of zinc or aluminum and is cast directly around the base (6) of the cap (3) and has a thin flange extending between the base (6 )of the cap (3) and the outer surface (7) of the dielectric (2). The exterior surface (31) of the solid body of revolution (30) curves upwardly so as to provide between such exterior surface and the outer surface (7) of the dielectric (2) an area for the self-extinguishing of electric arcs.
Patent NZ-220394-A (NZ)
Title: Aqueous steroid formulation adapted for intranasal application and having an anti-inflammatory effect
Inventor: BENJAMIN ERIC JOEL
IPC: A61K9/12
Filed: 1987-05-21
Abstract: A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10% (w/v); PEG 400 in an amount between about 10% and about 25% (w/v); polysorbate 20 in an amount between about 1% and about 4% (w/v); an effective amount of a preservative; an effective amount of a stabilizer; an effective amount of an antioxidant; water; and pH buffering agent sufficient to adjust the pH of the resulting solution to between about 3.5 and about 7.
Patent NZ-229946-A (NZ)
Title: Monoclonal antibody to gangliosides gq1b and gt1a and hybridomas producing it
Inventor: YOSHITAKA NAGAI
IPC: C12N5/20
Filed: 1989-07-14
Abstract: A monoclonal antibody is disclosed that specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: <CHEM> The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula with (B) myeloma cells. The monoclonal antibody shows a high specificity for ganglioside GQ1b and ganglioside GT1a having a specific epitope and thus can detect the epitope with a high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody has various clinical applications.
Patent NZ-230120-A (NZ)
Title: Substituted dihydropyridine derivatives and herbicidal compositions
Inventor: CHUPP JOHN PAUL
IPC: C07D211/72
Filed: 1989-07-28
Abstract: Compounds of general formula <CHEM>  wherein:  one of Y1 and Y2 is <CHEM>  in which Z1 is selected from -SR, -OR, <CHEM> where R, R4 and R5 are the same or different and are selected from alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, and cyanoalkyl, and <CHEM> is selected from azetidinyl and a saturated or unsaturated 5-membered heterocyclic ring moiety containing 1-2 nitrogen atoms, the remaining atoms being carbon atoms, optionally substituted with 1 to 3 groups which are the same or different and are selected from alkyl, alkoxy, cyano, halo, nitro, haloalkyl, alkoxyalkyl, and dialkoxyalkyl; Z2 is selected from O and S;  the other of Y1 and Y2 is <CHEM>  where <CHEM>  is as defined above; R1 and R2 are independently selected from fluorinated methyl, chlorofluorinated methyl, chlorinated methyl, and lower alkyl radicals, provided that one of R1 and R2 must be a fluorinated methyl or chlorofluorinated methyl radical; X is selected from lower alkyl, cycloalkylalkyl, alkoxyalkyl and alkylthioalkyl, useful as halicids.
Patent NZ-241537-A (NZ)
Title: Chemiluminescent assay method and apparatus
Inventor: LELAND JOHN K
IPC: C12Q1/68
Filed: 1992-02-05
Abstract: The invention relates to an apparatus for performing a binding assay for an analyte of interest in a sample based upon measurement of electro-chemiluminescence at an electrode surface comprising an electrochemical cell having a sample-holding volume, inlet and outlet means; a working electrode system to provide electrochemical energy to trigger electrochemiluminescence; a voltage control device to supply voltage signals to the working electrode system; a magnet placed in proper orientation and in close proximity to the working electrode so that magnetically responsive particles will concentrate on the surface of the working electrode; a light detection/measurement device for measuring electrochemiluminescence triggered at the electrode surface; and a pump to provide for fluid transport to, through and from the electrochemical cell. The apparatus may be used in an electrochemiluminescence assay for an analyte of interest in which magnetically responsive particles are magnetically collected on the electrode surface and emitted electrochemiluminescence is measured using the light detector. <IMAGE>
Patent NZ-247966-A (NZ)
Title: Benzamide derivatives and fungicidal compositions
Inventor: LATORSE MARIE-PASCALE
IPC: A01P3/00
Filed: 1993-06-23
Abstract: 1) Compounds of the phenylbenzamide family. 2) They are of formula (I): <IMAGE>  in which:   - R1 and R2, which are identical or different, are a hydrogen or halogen atom or an optionally halogenated alkyl radical, and - R3 and R4, which are identical or different, are an alkyl containing 1 to 4 carbon atoms or can form, together with the nitrogen atom which carries them, a morpholino ring.   3) Fungicides applicable in agriculture.
Patent NZ-255759-A (NZ)
Title: Tissue papers treated with non-ionic surfactant softeners (sorbitan esters)
Inventor: FERESHTEHKHOU SAEED
IPC: D21H17/14
Filed: 1993-08-12
Abstract: Tissue papers, in particular pattern densified tissue papers, having an enhanced tactile sense of softness when treated with certain nonionic softeners are disclosed. These nonionic softeners are biodegradable and comprise sorbitan esters, ethoxylated/propoxylated versions of these sorbitan esters, or mixtures thereof. The softener is typically applied from an aqueous dispersion or solution thereof to at least one surface of the dry tissue paper web.
Patent NZ-261922-A (NZ)
Title: Cage screen for pressurised lignocellulose fibre suspension: support with radial clearance
Inventor: LARSSON PAR-ERIK
IPC: D21D5/16
Filed: 1994-01-12
Abstract: PCT No. PCT/SE94/00013 Sec. 371 Date Aug. 7, 1995 Sec. 102(e) Date Aug. 7, 1995 PCT Filed Jan. 12, 1994 PCT Pub. No. WO94/18387 PCT Pub. Date Aug. 18, 1994A pressurized screen arrangement for screening lignocellulose containing fiber material, comprising a screen housing (10) with a screen cage (11) are arranged in first and, respectively, second attachment members (17, 18) in the screen housing. Both ends of the screen cage (11) are fitted into the attachment members (17,18) with radial clearance, and an axial support (21) is provided at least at one of the attachment members (17,18).
Patent NZ-264896-A (NZ)
Title: P-hydroxyaniline derivatives, intermediates and biocidal compositions thereof
Inventor: WAGNER OLIVER
IPC: C07C233/24
Filed: 1994-11-10
Abstract: p-Hydroxyaniline derivatives of the formula I <IMAGE>  in which the substituents have the following meanings:     R<1> is hydrogen or optionally substituted alkyl; R<2> and R<3> independently of one another are halogen, alkyl, haloalkyl, alkoxy and haloalkoxy; R<4> is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl, OR<5> or NR<6>R<7>, where R<5> and R<6> are optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl and   R<7> is hydrogen or alkyl, and salts thereof, their preparation, compositions comprising them, and their use as fungicides or pesticides; furthermore compounds of the formula VI <IMAGE> and salts thereof, processes for their preparation, compositions comprising them, and their use as intermediates and as pesticides.
Patent NZ-270207-A (NZ)
Title: Composition for reducing spray drift comprising guar (gum) or derivatives thereof; method of reducing spray drift during aerial spraying
Inventor: HAZEN JAMES
IPC: A01N37/18
Filed: 1994-12-20
Abstract: The drifting of aerial spraying or scattering of aqueous compositions is controlled by using suitable nonviscoelastic quantities of guar gum or else of one or more guar gum derivatives or of their combinations. Applications to the preparation of aqueous formulations for spraying, especially in the field of agricultural chemicals.
Patent NZ-289874-A (NZ)
Title: Displayed posters carried on moving bands into parallel spaced display positions
Inventor: CRIVELLI ALAIN
IPC: G09F21/04
Filed: 1995-07-13
Abstract: A series of posters or similar panels (4) are attached to individual support sheets (1,2) of flexible material wound at least partly around a drum (5). A control system allows unwinding of the sheets from the drum such that the poster appears in a selected position, e.g. behind a display aperture or window (9). A series of posters may be mounted in slightly varying positions, such that their display positions are in planes (a-e) slightly differently spaced relative to the window. Movement of the support sheets and posters is controlled by traction cords wound around drive pulleys (7), and the posters are secured by transverse bars and lateral fastening strips of the support sheet. <IMAGE>
Patent NZ-314047-A (NZ)
Title: Conveying apparatus with a plenum chamber beneath the perforated bottom of a trough, typically for heating or cooling food down spiralling trough
Inventor: PERRINE PAUL MELVIN
IPC: A23L5/10
Filed: 1998-04-08
Abstract: Food items slide down spiraling trough B. Fan D pressurizes a plenum chamber which supplies gas through perforations in the underside of trough B. Perforations may also be provided in the top or sides of the trough, and various other details are disclosed.
Patent NZ-336360-A (NZ)
Title: Printing on a substrate an outline and applying sufficient energy to the outline to weaken the outline
Inventor: RAFFAELE PETER ROBERT
IPC: B41M3/00
Filed: 1997-11-21
Abstract: The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma. Specifically disclosed TIGR sequences denoted as SEQ ID NOS 1, 3, 4, 5 8, 12 & 26.
Patent NZ-337234-A (NZ)
Title: Cable tray with a central spine carrying a series of parallel rungs, the outer end portion of each rung bent upwardly to a relatively small radius
Inventor: FERRIER IAN ROSS
IPC: F16L/
Filed: 1999-08-16
Abstract: The specification describes a cable tray.  The tray has a central spine (10) carrying a series of parallel rungs (2).
Patent NZ-500550-A (NZ)
Title: Strapping apparatus with pivoting plate transferring motion from lever to rewinding locks via transmitting mechanisms
Inventor: MARSCHE BERND
IPC: B65B13/02
Filed: 1999-10-21
Abstract: In order to control functions of strapping apparatus from one location, movement of plate-shaped control board 14 is transmitted via mechanisms  so that rewinding locks can be transferred from a locking position into an insertion position, and vice versa.
Patent NZ-501725-A (NZ)
Title: Depth keeping device for submersible vehicle or array with a variable volume buoyancy chamber
Inventor: MEAD ANDREW COLIN
IPC: B63B22/18
Filed: 1998-06-25
Abstract: A depth sensing device for a submersible vehicle or array includes an air chamber 10 and hydraulic fluid chambers 7, 8. The wall separating the air chamber 10 and fluid chamber 7 is a piston 9.  The depth is sensed by a pressure sensor 5, and a depth signal is sent to a controller 6.  If the sensed depth is below a set depth, then fluid is pumped from chamber 7 to chamber 8 by a pump 3.  The outer wall 11 of chamber 8 is in the form of a piston so that chamber 8 can expand to accommodate the fluid pumped in from chamber 7.  As fluid is pumped from chamber 7, piston 9 moves to allow chamber 10 to expand, thus increasing buoyancy.  If the sensed depth is above the sensed depth, then fluid moves from chamber 8 to chamber 7, causing piston 9 to reduce the volume of chamber 10, causing buoyancy to decrease.
Patent NZ-503763-A (NZ)
Title: Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
Inventor: JACKSON JAMES W
IPC: A61P31/04
Filed: 1998-10-01
Abstract: A high molecular weight ("HMW") protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same.  Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
Patent NZ-504893-A (NZ)
Title: 5, 6, 7, 8-Tetrahydro-[1,8]-naphthyridin-2-yl derivatives useful as integrin receptor antagonists
Inventor: HUTCHINSON JOHN H
IPC: A61K31/155
Filed: 1998-12-14
Abstract: A compound of the formula (I) X-Y-Z-C(R5)(R6)-C(R7)(R8)-CO2R9 or the pharmaceutically acceptable salts thereof wherein: X is -C=N-R1]-NR1R2, a 5-or 6-membered monocyclic optionally substituted aromatic or nonaromatic ring system or a 9-to 14-membered polycyclic ring system having 0 to 4 heteroatoms selected from =N-, -N(R1)-, -O-, and -S-; Y is -(CH2)m-, -(CH2)m-O-(CH2)n-, -(CH2)m-NR4-(CH2)n-, -(CH2)m-S-(CH2)n-, -(CH2)m-SO-(CH2)n-, -(CH2)m-SO2-(CH2)n-, -(CH2)m-O-(CH2)n-O-(CH2)p-, -(CH2)m-O-(CH2)n-NR4-(CH2)p-, -(CH2)m-NR4-(CH2)n-NR4-(CH2)p, -(CH2)m-O-(CH2)n-S-(CH2)p-, -(CH2)m-S-(CH2)n-S-(CH2)p-, -(CH2)m-NR4-(CH2)n-S-(CH2)p-, -(CH2)m-NR4-(CH2)n-O-(CH2)p-, -(CH2)m-S-(CH2)n-O-(CH2)p- or -(CH2)m-S-(CH2)n-NR4-(CH2)p-  with any methylene (CH2) carbon atom in Y, other than in R4, can be substituted by one or two R3 substituents; Z is -C(O)-NR4, -NR4-C(O)-, -NR4-C(O)-NR4-, -CH2CH2- or CH=CH-, wherein either carbon atom can be substituted by one or two R3 substituents; R1 to R8 are as defined in the specification, R9 is hydrogen, alkyl, aryl, aryl-alkyl, alkylcarbonyloxy-akyl, aryl-alkylcarbonyloxy-alkyl, alkylaminocarbonyl-ethylene or dialkylamino-arbonylmethylene; each m and n are independently 0 to 6 and each p is independently an integer from 0 to 2. A pharmaceutical acceptable composition thereof is useful for eliciting an integrin receptor antagonizing effect in a mammal in need thereof such as inhibition of bone resorption, restenosis, angiogenesis, diabetic retinopathy, macular degeneration, inflammation, viral disease, tumor growth, and metastasis.
Patent NZ-505892-A (NZ)
Title: Alpha-ketoamide inhibitors of 2os proteasome
Inventor: WANG LISA
IPC: C07K5/023
Filed: 1999-01-19
Abstract: A method for inhibiting cell proliferation mediated by 20S proteasome in mammals that uses a therapeutically effective amount of an alpha -ketoamide compound of formula (I).
Patent NZ-514021-A (NZ)
Title: Heteroaryl diazacycloalkanes, their preparation and use
Inventor: NIELSEN SIMON FELDBAEK
IPC: A61K31/44
Filed: 2000-04-19
Abstract: The present invention relates to novel heteroaryl diazacycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Patent NZ-516907-A (NZ)
Title: DNA and RNA ligands to tenascin-C containing 2'-F and 2'OMe modifications
Inventor: HICKE BRIAN
IPC: C12Q1/68
Filed: 2000-01-28
Abstract: Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Including those that are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin- C is expressed.