baber/WOPTO huggingface dataset:
Patent JP-2001506081-A (JP)
Title: リング・トリップ検出方法および装置
IPC: H04M19/02
Filed: 1997-11-18
Abstract: (57)【要約】
リング・トリップ検出器は、呼出し信号を整形するバッテリ電流発生器を制御するための基準カウンタと、電話回線電流に比例するあるノード電圧における零通過を検出するための零通過検出器と、２個の別のカウンタを有する。電圧の零通過によって、零通過検出器の正および負の両方の零交差において、パルスが生成される。これらのパルスが現れると、基準カウンタが記憶装置にゲートを開く。前回および今回の呼出し周期の零通過が記憶装置に記憶される。カウンタが、前回および今回の呼出し周期の零通過間の差を決定する。前回および今回の呼出し周期間の零通過の差が、固定値より大きい場合には、その出力は「位相差」を示し、それが固定値よりも小さい場合には、「位相差なし」を示すことになる。呼出しバースト信号の開始時に、別のカウンタが「位相差なし」の所定数の連続する呼出し周期を計数し、呼出しバースト信号を確立した後、別の所定数の連続する「位相差」の呼出し周期が計数され、リング・トリップが検出される。
Patent JP-H11501265-A (JP)
Title: 注型装置及び注型装置用アダプタ
IPC: B29C33/04
Filed: 1996-02-24
Abstract: (57)【要約】
熱硬化性プラスチックのためのリザーバ及び該リザーバから加熱可能な注型成形型（１）内にプラスチックを供給するための供給手段を有する注型成形装置であり、該装置を用いて、前記熱硬化性プラスチックを前記注型成形型（１）に導入することにより、前記プラスチックは少なくともこのようにして成形された注型品が成形型から離型され得る程度に前記注型成形型内で硬化され、前記成形型は、少なくとも成形すべき注型品の長さの大部分に沿って延びる入口開口部を有する注型装置であって、別個のアダプタ（２）を含み、この中に、前記プラスチックのための供給手段（２０，２２１，２３）が配置され、そしてアダプタ（２）は、該アダプタ（２）が接続された場合に、該アダプタ（２）に設けられた前記出口開口部（２３）は、前記注型成形型（１）の入口開口部に密着連結され且つ該入口開口部に実質的に適合して配置されるように前記注型成形型（１）に接続され得るところの注型装置。
Patent JP-H09511969-A (JP)
Title: けん引ベルトを使用した輸送システム
IPC: B61B13/12
Filed: 1995-04-12
Abstract: (57)【要約】
車両（２１）と、車両（２１）に連結して車両を輸送経路（２３）に沿って推進するのに十分なけん引力を付加する伸張し柔軟なけん引ベルト（２２）と、けん引ベルト（２２）を転置するために連結した駆動組立体（２４）を含む輪送システム。けん引ベルト（２２）は、側面（３３）が実質的に垂直面にあって車両（２１）をベルトの１つの端部（３８）に連結でき、他端（３９）をベルトの垂直位置を誘導するのに使用できるように配向する。端部（３８、３９）の中間では、駆動組立体（３６、３７）を輪送経路（２３）の延長に沿って周期的に配設して、誘導面（５６、５７、５８）あるいは車両連結組立体（５１）のいずれからも障害なしにけん引ベルトと摩擦係合して駆動できる。車両（２１）とけん引部材ベースの輪送システムを推進する方法を提供し、ベルトを垂直に配向している間にけん引力をけん引ベルト（２２）を通して車両（２１）に付加するステップを含む。
Patent JP-2000503846-A (JP)
IPC: C12N15/09
Filed: 1997-01-22
Abstract: Provided herein is a method for analyzing a target nucleic acid to determine the number of tandemly repeated sequences, which may form a part of the target sequence, relative to a complementary oligonucleotide. Also provided is a target sequence capture reagent for capturing a target sequence which comprises a tandemly repeated sequence.
Patent JP-2001506248-A (JP)
Title: ３，４−ジヒドロ−２ｈ−１，３−オキサジン−ジオン誘導体とヒドラジン（付加物）を反応させることによる３−アミノ−１−フェニル−ウラシル誘導体の製造法
IPC: C07D239/54
Filed: 1997-12-05
Abstract: (57)【要約】
本発明の方法によれば、式
 ［式中、Ｒ 1 、Ｒ 2 、Ｒ 3 、Ｒ 4 及びＲ 5 は前述の通りである］の３−アミノ−１−フェニル−ウラシルは、式
 の置換フェニルオキサジン−ジオンを、適当ならば酸受容体の存在下に及び適当ならば希釈剤の存在下に、式
 のヒドラジンハイドレートと反応させることにより製造することができる。
Patent JP-H10504799-A (JP)
Title: パーハロアルコキシベンゼノフェノンヒドラゾンおよび有害生物防除剤としてのそれらの用途
IPC: C07C311/46
Filed: 1995-04-15
Abstract: (57)【要約】
次式：
 を表し、ｎは０、１、２、３、４または５を表し、ｎが１より大きい場合、基Ｒ 2 は同一または相違しており、ｏは０、１、２、３または４を表し、ｏが１より大きい場合、基Ｒ 3 は同一または相違しており、Ｒ 1 はパーハロ−炭素原子数１ないし４のアルコキシ基を表し、Ｒ 2 はハロゲン原子、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ基、ハロ−炭素原子数１ないし８のアルコキシ基、炭素原子数１ないし８のアルキルチオ基、ハロ−炭素原子数１ないし８のアルキルチオ基、炭素原子数１ないし８のアルキルスルフィニル基、ハロ−炭素原子数１ないし８のアルキルスルフィニル基、炭素原子数１ないし８のアルキルスルホニル基、ハロ−炭素原子数１ないし８のアルキルスルホニル基、ＣＮ基またはフェニル基を表し、Ｒ 3 はハロゲン原子、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基またはハロ−炭素原子数１ないし８のアルコキシ基を表し、Ｒ 4 はＨ、ハロゲン原子、炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ基、炭素原子数１ないし８のアルコキシ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ−炭素原子数１ないし８のアルコキシ基、炭素原子数１ないし８のアルキルチオ基またはＮＲ 8 Ｒ 9 基を表し、Ｒ 5 は炭素原子数１ないし８のアルキル基、ＮＲ 10 Ｒ 11 基、ＯＲ 20 基、ＳＲ 20 基またはＳＯ 2 Ｒ 20 基を表し、Ｒ 6 はＨ、炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルケニル基、炭素原子数１ないし８のアルキニル基、炭素原子数１ないし８のアシル基またはフェニル基を表し、Ｒ 7 はＨ、非置換または置換された炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、炭素原子数３ないし６のシクロアルキル−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルケニル基、炭素原子数１ないし８のアルキニル基、炭素原子数３ないし６のシクロアルケニル基、炭素原子数３ないし６のシクロアルケニル−炭素原子数１ないし８のアルキル基または炭素原子数３ないし６のシクロアルキル−炭素原子数１ないし８のアルケニル基を表し、置換基はハロゲン原子、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ基、ハロ−炭素原子数１ないし８のアルコキシ基、炭素原子数１ないし８のアルキル−Ｓ（Ｏ） p 基（式中、ｐは０、１または２であってよい）、炭素原子数１ないし８のアルコキシカルボニル基、ジ（炭素原子数１ないし８のアルキル）アミノ基および炭素原子数１ないし８のアルカノイルオキシ基からなる群から選択され得；またはＲ 7 は非置換または置換されたフェニル基またはヘテロアリール基を表し、置換基は炭素原子数１ないし６のアルキル基およびハロゲン原子からなる群から選択され得；またはＲ 7 は炭素原子数１ないし８のアルコキシ基、ＮＲ 16 Ｒ 17 基、ＣＯＯＲ 6 基またはＳＲ 6 基を表し、Ｒ 8 およびＲ 9 は互いに独立してＨ、炭素原子数１ないし８のアルキル基またはＯＨ基を表し、Ｒ 10 はＨ、炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、ハロ−炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルコキシ−炭素原子数１ないし８のアルキル基、フェニル基、ＯＲ 12 基、Ｓ（Ｏ） m Ｒ 13 基（式中、ｍは０、１または２を表す）またはＮＲ 14 Ｒ 15 基を表し、Ｒ 11 はＨ、炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ−炭素原子数１ないし８のアルキル基、アリル基、炭素原子数１ないし８のアルキルアリル基、ハロアリル基またはプロパルギル基を表し、Ｒ 12 はＨ、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ−炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、炭素原子数２ないし８のアルケニル基、ハロ−炭素原子数２ないし８のアルケニル基またはプロパルギル基を表し、Ｒ 13 はＨ、炭素原子数１ないし８のアルキル基、ハロゲン−炭素原子数１ないし８のアルキル基、フェニル基またはＮＲ 14 Ｒ 15 基を表し、Ｒ 14 およびＲ 15 は互いに独立してＨ、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、フェニル基、炭素原子数１ないし８のアルキルアミド基、ジ（炭素原子数１ないし８のアルキル）アミド基またはＮＨ 2 基を表し、Ｒ 16 およびＲ 17 は互いに独立してＨ、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数２ないし８のアルケニル基、炭素原子数１ないし８のアルコキシ基またはＮＨ 2 基を表し、Ｒ 18 はＳ（Ｏ） m Ｒ 19 基（式中、ｍは０、１または２を表す）、ＮＯ 2 基またはＣＮ基を表し、Ｒ 19 は炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数３ないし６のシクロアルキル基、フェニル基、ベンジル基またはＮＲ 14 Ｒ 15 基を表し、Ｒ 20 は炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基または炭素原子数３ないし６のシクロアルキル基を表し、ＹはＯ、Ｓ、ＮＲ 18 基またはＣＨＣ（Ｏ）Ｒ 21 基を表し、そしてＲ 21 はＨ、炭素原子数１ないし８のアルキル基、ハロ−炭素原子数１ないし８のアルキル基、炭素原子数１ないし８のアルコキシ基またはフェニル基を表す〕で表される各々の場合において遊離体または塩の形態にある化合物、および適当である場合にはそのＥ／Ｚ異性体および互変異性体は農薬の有効な成分として使用され得、そしてそれ自体公知の方法で製造され得る。
Patent JP-2000504645-A (JP)
IPC: C23C14/56
Filed: 1997-01-16
Abstract: The present invention provides an improved method for making a solar control sheet having one or more metal layers. In the prior art solar control sheets, each metal layer would normally be non-porous so that water vapor would not be readily transmitted therethrough. However, in this invention the metal layer is rendered porous because it is deposited on a porosity inducing surface. The porosity inducing surface may be the surface of a porous primer layer or a surface which has been roughened. Consequently when the solar control film of this invention is mounted on a window with a water based mounting media, the water can quickly evaporate through the film without causing undesirable cloudiness which is normally associated with water which becomes trapped between the film and the window.
Patent JP-H11503235-A (JP)
Title: グルタチオンｓ−トランスフエラーゼの一種以上のイソ酵素の検出を基礎とした器官の状態の迅速評価検定
IPC: C12Q1/48
Filed: 1996-04-02
Abstract: (57)【要約】
異なる生物学的流体中のグルタチオンＳ−トランスフエラーゼ（ＧＳＴ）の一種以上のイソ酵素の検出を基礎とする、対象中の免疫学的または毒物学的傷害に続く器官の損傷を含む、器官の状態の迅速評価方法であって、当該方法は、前記イソ酵素に特異的な粒子−標識抗−ＧＳＴ抗体と前記イソ酵素の含有の疑いのある生物学的流体の試料とを接触させること、ここで、前記抗体が前記イソ酵素の少なくともピコモル量を検出するのに足る感度を有し、そして固定化されている捕捉抗体上で粒子−標識抗体−イソ酵素複合体を捕捉し視覚的に検出できる信号を発生することを含む前記方法。この方法は、固定化された抗−ＧＳＴ抗体との最初の接触から３０分程度の時間内で典型的にはＧＳＴイソ酵素の検出または決定をできる。この方法は使用が簡易であり、したがって、例えば、肝臓または腎臓の移植に続く特殊なＧＳＴイソ酵素の量を監視するのに家庭内で患者により使用できる。
Patent JP-2000508022-A (JP)
Title: （ヒドロキシアルキル）尿素架橋剤
IPC: C08L33/02
Filed: 1998-01-07
Abstract: (57)【要約】
（ヒドロキシアルキル）尿素架橋剤及び前記架橋剤を用いる組成物が開示されている。前記架橋剤は唯一の尿素基、少なくとも２個の水酸基を含有し、前記尿素基と各水酸基との間に配置された少なくとも２個の炭素原子を有する。前記組成物は、カルボキシ、酸無水物及びアミンからなる群から選択される少なくとも２個の官能基を含有する多官能分子を含有する。
Patent JP-2000508825-A (JP)
Title: 生体医療用電極用の導電体、およびそれから作成された生体医療用電極
IPC: H01B1/24
Filed: 1996-04-29
Abstract: (57)【要約】
導電体とその導電体を使用する生体医療用電極とが開示される。この導電体は、可撓性不導性フィルム（２）と、そのフィルム（２）の主表面上の２つの異なる炭素含有被膜（４、６）とを有する。これらの導電体被膜は、低多孔性炭素含有被膜（４）と高多孔性炭素含有被膜（６）とである。この低多孔性炭素含有被膜（４）はフィルム（２）と接触し、高多孔性炭素含有被膜（６）は低多孔性炭素含有被膜（４）と接触する。この導電体を使用するタブ／パッド式生体医療用電極は、高多孔性炭素含有被膜（６）と接触する電解質を含有するイオン伝導性媒体のフィールドを有する。この電解質は、電気化学的利益のために高多孔性炭素含有被膜（６）内に分散する。
Patent JP-2001527536-A (JP)
IPC: A61P31/18
Filed: 1998-03-12
Abstract: Disclosed is a method of down-regulating the expression of a gene in an animal, wherein an oligonucleotide complementary to the gene is colorectally administered to an animal. Also disclosed is a method for introducing an intact oligonucleotide into a mammal by colorectal administration, whereby the oligonucleotide is present in intact form in the systemic plasma of the mammal at least four hours following administration.
Patent JP-2000511188-A (JP)
IPC: A61K47/48
Filed: 1997-05-22
Abstract: The invention provides taxanes that are conjugates of cis-docosahexaenoic acid and taxotere. The conjugates are useful in treating cancer.
Patent MD-20060281-A (MD)
Title: Energy efficient process for hydrogen obtaining
Inventor: BERZAN VLADIMIR
IPC: C25B1/02
Filed: 2006-12-18
Abstract: The invention relates to electrochemistry, particularly to a hydrogen obtaining process.Summary of the invention consists in that through an electrolytic cell (5) is passed unidirectional electric current. One electrode (3) is made reacting and to it is applied the positive side of the power supply, and in the storage mode the power supply is disconnected. Additionally in this cell it is introduced a nonreacting electrode (4) and between it and the reacting electrode (3), in the storage mode, it is applied a voltage of the power supply lower than that necessary for electrolysis, with the negative polarity on the reacting electrode, and as electrolyte is used ammonium salt.
Patent NZ-203192-A (NZ)
Title: 5,10-dihydro-11 h-dibenzo(b,e)(1,4)diazepin-11-one derivatives,methods for their preparation and pharmaceutical compositions
Inventor: TRUMMLITZ G
IPC: C07D401/06
Filed: 1983-02-04
Abstract: The specification describes new substituted dibenzodiazepinones of formula    <IMAGE>  (I)  wherein R1 is hydrogen or chlorine atom and R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl,1-methyl-1,2,5,6-tetra hydro-4-pyridinyl, (1-methyl-4-piperidinylidene)methyl,(2,3-dehydro-8-methyl-8-aza-bicycl o[3,2,1]oct-3-yl)-methyl, (8-methyl-8-aza-bicyclo[3,2,1]oct-3-ylidene)-methyl or an endo-or exo-(8-methyl-8-azabicyclo[3,2,1]oct-3-yl)methyl each being optionally substituted by one or two methyls on the heterocyclic ring, and the nontoxic, pharmaceutically acceptable acid addition salts thereof, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds of formula I have an antiulcerative effect and an inhibitory effect on the secretion of gastric substances having anticholinergic activity, such as dryness of the mouth and mydriasis.
Patent NZ-216062-A (NZ)
Title: Method of making a drug microcapsule formulation
Inventor: CALANCHI M
IPC: A61K9/50
Filed: 1986-05-05
Abstract: The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and dissolving quickly in water or aqueous vehicles, without clot formation, with which it is possible to prepare an extermoraneous homogeneous suspension of solid particles and more particularly of micro-encapsulated drugs, which otherwise have the tendency to precipitate or float.
Patent NZ-217466-A (NZ)
Title: An orientated multilayer film having oxygen barrier characteristics
Inventor: SHAH G P
IPC: B29C47/06
Filed: 1986-09-04
Abstract: A coextruded multiple layer oriented film comprises a core layer of a blend of ethylene vinyl alcohol copolymer and polyamide, two intermediate adhesive layers, and two outer layers of a blend of linear low density polyethylene, linear medium density polyethylene, and ethylene vinyl acetate copolymer. A preferred embodiment of the multilayer film exhibits excellent optics and shrink properties while providing high oxygen barrier especially useful in food packaging applications.
Patent NZ-220576-A (NZ)
Title: L-2-amino-4-(hydroxymethylphosphinyl)butyric acid produced by fermentation/transamination
Inventor: SATOSHI IMAI
IPC: C07F9/30
Filed: 1987-06-05
Abstract: A new process of producing L-2-amino-4-(hydroxymethylphosphinyl)-butyric acid (L-AMPB) is now provided, in which 4-(hydroxymethylphosphinyl)-2-oxo-butyric acid (OMPB) is treated with one or more transaminases or with one or more microorganisms capable of producing the transaminase, in the presence of one or more amino-donor compounds such as  alpha -amino acids. According to this process, the optically active L-AMPB useful as herbicidal agent can be produced efficiently in a facile way for a reasonable reaction time.
Patent NZ-221298-A (NZ)
Title: A recombinant vaccine comprising an antigenic polypeptide component together with a lymphokine component
Inventor: RAMSHAW IAN ALLISTER
IPC: C12N7/01
Filed: 1987-07-31
Abstract: A recombinant vaccine comprises a vaccine vector which incorporates a first nucleotide sequence capable of being expressed as all or a part of an antigenic polypeptide, together with a second nucleotide sequence capable of being expressed as all or a part of a lymphokine effective in enhancing the immune response to the antigenic polypeptide. The vaccine vectors include poxvirus, herpes virus or adenovirus, and the lymphokine may be an interleukin or gamma-interferon. The vaccine vector may express an antigenic polypeptide which is foreign to the host vector.
Patent NZ-229376-A (NZ)
Title: Aryloxysubstituted propanolamines and pharmaceutical compositions
Inventor: BEEDLE EDWARD EARL
IPC: A61K31/536
Filed: 1989-06-01
Abstract: This invention provides a method of selectively antagonizing the 5-HT1 receptor in mammals by administering aryloxypropanolamines. Novel aryloxypropanolamines are also claimed.
Patent NZ-237950-A (NZ)
Title: Assay for betabbeta-lactam antibiotic involving d-alanyl-d-alanine carboxypeptidase of actinomadura r39
Inventor: DEGELAEN JACQUES
IPC: A61K38/00
Filed: 1991-04-26
Abstract: It entails the following stages: 1) incubation of the biological fluid with the soluble D-alanyl-D-alanine carboxypeptidase produced by the strain Actinomadura R39; 2) incubation of the mixture obtained with a solution of substrate, which is a thioester of formula 
<IMAGE>
 in the presence of an amino acid of D configuration or glycine; 3) determination of the quantity of 2-mercaptoalkanoic acid of formula 
<IMAGE>
 formed in stage 2); 4) comparison of the determination of stage 3) with a standard. 
<??>In these formulae: 
 
  R1 = benzoyl, phenylacetyl or Nalpha-acetyl-Llysyl, 
  R2 = glycyl or D-alanyl, and 
  R3 = H or CH3. 
 
<??>The invention also relates to a test kit comprising the reagents to be employed for implementation of the method.
Patent NZ-242731-A (NZ)
Title: Substituted phenolsulphone phthaleins; protein detection analytical test
Inventor: COREY PAUL F
IPC: G01N33/68
Filed: 1992-05-14
Abstract: The present invention provides a novel group of protein error indicators including nitro or nitroso substituent groups in the B and C rings of a partially halogenated triphenylmethane compound. Di-nitro or nitroso substituted protein error indicators of the present invention are represented by the structural formula: <CHEM> wherein: X is -Cl, -Br, -I; Y is -NO2 or -NO; and Z is -Cl, -Br, -I.   Mono-nitro or nitroso protein error indicator compounds of the present invention are illustrated by the following formula: <CHEM> wherein: X is -Cl, -Br, -I; Y' is -NO2 or -NO; Y'' is -Cl, -Br, -I; and Z is -Cl, -Br, -I.
Patent NZ-258311-A (NZ)
Title: Weed control; method and apparatus using high pressure liquid spray to lacerate vegetation
Inventor: THOMPSON JAMES E
IPC: B05B9/00
Filed: 1993-11-02
Abstract: An apparatus and method for controlling vegetation, as well as insect infestation, as are typically encountered in agricultural environments is disclosed. The apparatus is characterized by its construction to include a high pressure pump liquid spray material may be applied to vegetation at a pressure from about 100 psi to as much as about 4,000 psi. The apparatus further includes a heater whereby the liquid spray material may be heated to a temperature of from about 100 DEG  F. to about 240 DEG  F. before it is sprayed. The apparatus is constructed so that it can be attached to a standard tractor for ease of use. The method of this invention is characterized by its utilization of a high pressure spray so that agricultural chemicals in amounts from virtually 0% to about 50% of their current recommended dose rates can be used with efficacy.
Patent NZ-258653-A (NZ)
Title: Fruit grader with cup to receive fruit: cup tips to either side
Inventor: KENNEDY HAMISH NIGEL ALEXANDER
IPC: B65G47/96
Filed: 1993-12-16
Abstract: A plurality of carriers 1 and spaced apart along an endless conveyor in an article grading apparatus. The articles are supported between a roller 2 and a back plate 7. The rollers 2 can be raised and rotated, at which time, superfluous articles supported between the rollers 2 of consecutive carriers will be ejected so that with the lowering of the roller 2, only one or a selected number of the articles remain in a particular carrier 1. <IMAGE>
Patent NZ-265253-A (NZ)
Title: Aminooxy amino alkane derivatives and medicaments
Inventor: FREI JORG
IPC: A61P43/00
Filed: 1994-04-02
Abstract: PCT No. PCT/EP94/01036 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 2, 1994 PCT Pub. No. WO94/24094 PCT Pub. Date Oct. 27, 1994   <IMAGE>  (I)  Compounds of formula (I) in which (a) four of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the others independently of one another are in each case C1-C2alkyl, these groups being bonded to the same carbon atom or to two different carbon atoms, or (b) five of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the other radical is C1-C2alkyl or hydroxymethyl, or salts thereof, are described. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.
Patent NZ-298116-A (NZ)
Title: 1,2,3,4-substituted naphthalene pesticidal compositions
Inventor: KHAMBAY BHUPINDER PALL SINGH
IPC: C07C225/30
Filed: 1996-01-10
Abstract: The use of compound of general formula (I) or a salt thereof wherein: n represents an integer from 0 to 4; m represents an integer 0 or 1; each R independently represents a halo, a nitro, cyano, hydroxyl, alkyl, alkenyl, haloalkyl, haloalkenyl, alkoxy, haloalkoxy, haloalkenoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, carboxyl, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, alkylamido, cycloalkyl, aryl or aralkyl group; R1, R2, R7 and R8 each independently represent an optionally substituted alkoxy group or together represent a group =O, =S or =N-OR9,  where R9 is  hydrogen atom or an optionally substituted alkyl group; R3 represents a hydroxyl group, or a group -OL where L is a leaving group, or a group which in vivo is transformed into a group -OL1 where L1 is a leaving group; R4 and R5 independently represent hydrogen, halogen or an optionally substituted alkyl or alkenyl group or together with the interjacent carbon atom represent an optionally substituted cycloalkyl or cycloalkenyl ring and A represents an optionally substituted alkyl or alkenyl group, an acyclic carbon chain of which links the 3-position of the naphthalene ring shown and the moiety -CHR4R5 provided that A does not include a quaternary carbon atom in that chain and the total number of carbon atoms in the longest carbon chain running from the 3-position of the naphthalene ring shown is no more than 8 as a pesticide against whitefly, Lepidoptera and certain fungi is claimed.
Patent NZ-308789-A (NZ)
Title: Tetralin derivatives and medicaments
Inventor: ZELLE ROBERT E
IPC: A61K31/44
Filed: 1996-05-16
Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer.
Patent NZ-314103-A (NZ)
Title: Stereoselective preparation of heterobicyclic alcohol enantiomer; intermediates
Inventor: BUIZER NICOLAAS
IPC: C07D265/00
Filed: 1997-01-22
Abstract: The invention relates to a method for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula <CHEM>  wherein     X is O, S, NH or N-(C1-C4)alkyl; Y1 and Y2 are each independently hydrogen or substituents selected from halogen, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, formyl, nitro and cyano;   the C*-atom has either the R or the S configuration;  is prepared from a compound of the general formula <CHEM> wherein R1 is hydrogen or a suitable protective group and R2 is hydrogen or wherein R1 and R2 together form an optionally mono- or di-(C1-C3)alkyl substituted methylene bridge;  by the following successive reaction steps:     (i) reaction with a compound of the general formula <CHEM> wherein Z is a hydroxy group or a suitable leaving group, R3 is a hydroxy-protective group and R4 is a halogen atom; or wherein R3 and R4 together constitute a valence bond or a biradical of the formula -C(R11)2-O-, wherein R11 is a straight or branched (C1-C4)alkyl group and wherein the C*-atom has either the R or the S configuration; (ii) subjection of the compound formed to a deprotection/ring-closure reaction; (iii) optionally deprotection of the hydroxy group of the ring-closed product. The invention further relates to enantiomerically pure intermediates, the preparation of these intermediates and the preparation of a starting compound.
Patent NZ-319474-A (NZ)
Title: Guanidino protease inhibitors
Inventor: LU TIANBAO
IPC: A61K31/445
Filed: 1996-09-27
Abstract: he compounds of the present invention represent a novel class of potent inhibitors of metallo, acid, thiol and serine proteases. Examples of the serine proteases inhibited by compounds within the scope of the invention include leukocyte neutrophil elastase, a proteolytic enzyme implicated in the pathogenesis of emphysema, chymotrypsin and trypsin, digestive enzymes, pancreatic elastase, and cathepsin G, a chymotrypsin-like protease also associated with leukocytes; thrombin and factor Xa, proteolytic enzymes in the blood coagulation pathway. Inhibition of thermolysin, a metalloprotease and pepsin, an acid protease, are also contemplated uses of compounds of the present invention. An end use application of the compounds that inhibit chymotrypsin and trypsin is in the treatment of pancreatitis.  R1 is C6-12 alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl, any of which may be optionally substituted;  Z is -NR10SO2-, -SO2-NR10-,-NR10C(RyRz)-,-C(RyRz) -NR10-,-SO2-,-SO2O-, OC(RyRz)-,C(RyRz)O-, NR10CO-or -CONR10-,  Y is -O-,-NR5-, -S-,-CR5R9- or a covalent bond;  W is N or CR10  R2,R3,R4,Ra,Rb and Rc and other variables are common substituents as defined in the specification
Patent NZ-330061-A (NZ)
Title: Process for recovering growth factors from milk or a milk derivative by separating out an growth factor enriched fraction and then further treating this fraction
Inventor: KUSSENDRAGER KLAAS DANIEL
IPC: C07K14/515
Filed: 1998-03-27
Abstract: The invention relates to a process for recovering one or more growth factors from milk or a milk derivative, comprising adsorbing at least one growth factor from the milk or the milk derivative to a cation exchanger, followed by fractionated elution of the cation exchanger, whereby at least one fraction is obtained which is enriched in growth factors, followed by the further treatment of this fraction at a pH of at least 3.5 and not more than 4.5.
Patent NZ-331860-A (NZ)
Title: Piperazine and piperidine compounds with affinity for both dopamine D2 and seratonin 5-HT1A receptors
Inventor: FEENSTRA ROELOF WILLEM
IPC: A61K31/495
Filed: 1997-03-20
Abstract: Piperazine and piperidine compounds of formula as above wherein A represents a heterocyclic group of 5-7 ring atoms wherein 1-3 heteroatoms from the group O, N and S are present; R1 is hydrogen or fluoro; R2 is C1-4-alkyl, C1-4-alkoxy or an oxo group, and p is 0, 1 or 2; Z represents carbon or nitrogen, and the dotted line is a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R3 and R4 independently are hydrogen or C1-4-alkyl; n has the value 1 or 2; R5 is halogen, hydroxy, C1-4-alkoxy or C1-4-alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which groups may be substituted with 1-3 substituents of the group hydroxy, halogen, C1-4-alkoxy, C1-4-alkyl, cyano, aminocarbonyl, mono- or di-C1-4-alkylaminocarbonyl; and salts thereof show high affinity for both the dopamine D2 and serotonin 5-HT1A receptors.  Methods for the preparation of the compounds are disclosed.