Patent GB-901637-A (GB)
Title: Mycobacteriostats
Inventor: BROWN JOSEPH PATRICK
IPC: C08K5/39
Filed: 1959-04-13
Abstract: Soaps, e.g. soaps derived from natural oils, such as potassium soap, common soap, waxes, e.g. beeswax, carnauba wax and paraffin wax and wax polishes contain a trithiopercarbamate of formula R.SS.CS.NR1R2 in order to inhibit the growth of bacteria and fungi, where R is an aryl group, R1 is a hydrogen atom, an aryl aralkyl, alkyl or cycloalkyl group and R2 is an aryl, aralkyl, cyclo alkyl or alkyl group or alternatively R1 and R2 together with the nitrogen atom form a heterocyclic ring, e.g. a piperidino or morpholino ring.  Specified trithio percarbamates are phenyl-N1N-dimethyl trithiopercarbamate, 2-nitrophenyl-N1N-dimethyl-trithiopercarbamate, 2-nitro phenyl-N1N-diethyl trithiopercarbamate, 4-chlorophenyl-N1N-dimethyl trithiopercarbamate, 4-ethoxyphenyl-N1 N-diethyl trithiopercarbamate, 3,5,-dichloro-4-ethoxyphenyl trithiopercarbamate and 2-nitrophenyl-N-(4 ethoxyphenyl) trithiopercarbamate.ALSO:Synthetic plastics, e.g. vinyl polymers and copolymers such as polystyrene, polyvinyl chloride or polyethylene, and phenol or melamine resins, are treated in order to inhibit the growth of bacteria and fungi, by adding a trithio percarbamate of formula R.SS.CSNR1R2, where R is an aryl group, R1 is a hydrogen atom, an aryl, aralkyl, alkyl, or cycloalkyl group and R2 is an aryl, aralkyl, cycloalkyl or alkyl group or alternatively R1 and R2 together with the nitrogen atom form a heterocyclic ring, e.g. a piperidine or morpholino ring.  Specified trithio percarbamates are phenyl N,N-dimethyl trithiopercarbamate, 2-nitrophenyl N,N-dimethyl-trithiopercarbamate, 2-nitrophenyl-N,N-diethyl trithiopercarbamate, 4-chlorophenyl-N,N-dimethy trithiopercarbamate, 4-ethoxyphenyl-N,N-diethyl trithiopercarbamate, 3,5-dichloro-4-ethoxyphenyl trithiopercarbamate and 2-nitrophenyl-N-(4-ethoxyphenyl) trithiopercarbamate.ALSO:A mycobacteriostatic composition which is a suspension, emulsion or solid, comprises an inert diluent and a trithiopercarbamate of the formula R.S.S.CS.NR1R2, where R is an aryl group, R1 is a hydrogen atom, an aryl, aralkyl, alkyl or cycloalkyl group and R2 is an aryl, aralkyl, cycloalkyl or alkyl group or alternatively R1 and R2 together with the nitrogen atom form a heterocyclic ring, e.g. a piperidino or morpholino ring.  Fruit vegetables and plants may be preserved against attack by fungi and bacteria by treating with said mycobacteriostatic composition or the active ingredient thereof. Preferred active ingredients are those in which R is a phenyl, alkyl phenyl, alkoxy phenyl, halophenyl or nitrophenyl group, e.g. 2-tolyl, 4-chlorophenyl, 2,4-dichlorophenyl, 2- or 4-nitrophenyl, 4-chloro-2-nitrophenyl or 3,5-dichloro-4-ethoxyphenyl and R1 and R2 are alkyl radicals containing 1-5 carbon atoms or aryl groups. Specified compounds are phenyl N,N-dimethyltrithio percarbamate, 2-nitrophenyl N,N-dimethyl-trithiopercarbamate, 2-nitrophenyl-N,N-diethyl-trithiopercarbamate, 4-chlorophenyl N,N-dimethyl trithiopercarbamate, 4-ethoxyphenyl N,N-diethyl trithiopercarbamate, 3,5-dichloro-4-ethoxyphenyl N,N-dimethyl trithiopercarbamate and 2-nitrophenyl-N-(4-ethoxyphenyl)-trithiopercarbamate.  The suspension may be an aqueous suspension with or without a surface active agent, e.g. a long chain alkylated aromatic sulphonic acid. The emulsions are obtained by dissolving the trithiopercarbamate in an organic solvent, e.g. toluene, cyclohexane, or petroleum ether, chloroform, chlorobenzene, castor oil, olive oil, cottonseed oil, rape oil or a mineral oil and emulsifying the solution in an aqueous medium with or without a surface-active agent.  A specified solid carrier is talc. The active ingredients may also be incorporated in soaps, waxes and synthetic plastics (see Groups III and IV (a)) and the mycobacteriostatic compositions may be used in treating leather and cloth (see Group VIII).