baber/WOPTO huggingface dataset:
Patent JP-2000502342-A (JP)
IPC: C07H21/00
Filed: 1996-12-13
Abstract: PCT No. PCT/CA96/00837 Sec. 371 Date Jun. 19, 1998 Sec. 102(e) Date Jun. 19, 1998 PCT Filed Dec. 13, 1996 PCT Pub. No. WO97/23497 PCT Pub. Date Jul. 3, 1997A linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (1), wherein: X1 is selected from the group consisting of -O-, -S-, -S(O)2-, -C(O)- and -N(R12)-; R12 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group, X3 is -O- or -N(H)-; R1, R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; n is 0, 1 or 2; and one of A' and B' is selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group, and the other of A' and B' has formula (2), wherein X2 is selected from the group consisting of -O-, -S-, -S(O)2- and -N(R13)-; R13 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group; R6 and R7 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; p is 0 or 1; and m is 0, 1 or 2. A process for producing the linker arm is also disclosed. The linker arm is useful in solid support oligonucleotide synthesis and is characterized by a desirable combination of stability against spontaneous hydrolysis and ease of intentional cleavage of the synthesized oligonucleotide from the linker arm.
Patent JP-H10513455-A (JP)
Title: 緑内障治療用のデプレニル化合物
IPC: A61P27/06
Filed: 1996-02-12
Abstract: (57)【要約】
緑内障の治療方法及び器具を開示する。概略的には、本発明の方法は、治療上効果的な量のデプレニル化合物を、被験者の緑内障を治療すべく被験者に対して投与することを含む。
Patent JP-H08509762-A (JP)
IPC: C10G32/02
Filed: 1994-04-29
Abstract: The invention relates to a process for the removal of mercury and/or other heavy metals from a cracker feed with the aid of an adsorbent. The process is characterized in that the feed is also subjected to magnetic filtration.
Patent JP-2000503160-A (JP)
Title: 電磁誘導加熱用コイル
IPC: H05B6/42
Filed: 1997-01-03
Abstract: (57)【要約】
片持ち電磁誘導加熱用コイルであって、重複するコイルセクション（２０、２１、２２、２３、２４、２５）を有し、該コイルセクションは互いに電気的に並列接続され、比較的大きなコイルを屈曲可能な細い銅製チューブから構成することを可能とし、他方離れた高周波発生機の周波数において共鳴タンク回路内に組み込むに十分な低いコイルインピーダンスを保持して上記発生機にタンク回路を接続するリード内でのパワーロスを最小にする。また、このコイルを使用する誘導回路方法は特にワイヤリングハーネスへの適用について記載してある。
Patent JP-H11503858-A (JP)
IPC: H01M8/12
Filed: 1995-03-14
Abstract: An electrochemical converter assembly having one or more converter elements having a peripheral edge. The converter element includes a series of electrolyte plates having an oxidizer electrode material on one side and a fuel electrode material on the opposing side, and a series of interconnector plates, alternately stacked with the electrolyte plates, that provide electrical contact with the electrolyte plates. The interconnector plate has a textured pattern that forms reactant-flow passageways. The converter assembly has a low pressure drop configuration that includes at least one passageway which is disposed generally in the central region of the converter element, for introducing one input reactant thereto, and at least one second passageway, for introducing the other reactant. A third passageway, outwardly spaced from the second passageway removes spent fuel from the reactant-flow passageways, and thus from the converter element. The spent reactants are discharged along the periphery of the electrochemical converter. The electrochemical converter assembly further includes a sealer material that forms a non-hermetic seal between the electrolyte plate and the interconnector plate.
Patent JP-2002515737-A (JP)
IPC: C12Q1/68
Filed: 1997-01-22
Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charg
Patent JP-2000514774-A (JP)
Title: スラッジ処理及び供給システム
IPC: C04B7/24
Filed: 1997-12-17
Abstract: (57)【要約】
本発明は、燃焼操作（例えばセメント製造）に付随する汚染物質放出を削減するために燃焼器にスラッジを処理し供給するためのシステムに関する。そのシステムは、燃焼手段、燃焼されるスラッジを受け取るための第１の受け取り手段、第１の受け取り手段からのスラッジをスラッジ導管に運ぶための手段、およびスラッジの燃焼により生成する汚染物質放出を効果的に削減する点においてスラッジ導管からのスラッジを燃焼手段に導入するための手段を備える。
Patent JP-2000513694-A (JP)
Title: 基板上に導電層を作製する方法
IPC: H01J9/20
Filed: 1998-03-19
Abstract: (57)【要約】
基板上に金属塩又は金属塩の混合物を含む層を形成し、この層をアルカリ溶液に接触させ、この層に熱処理（加熱）を施すことにより、一酸化金属又は多酸化金属を含む導電層を基板に被着する。
Patent JP-H11503958-A (JP)
IPC: A61F5/44
Filed: 1997-02-13
Abstract: A method for attaching a barrier cuff to an absorbent article. The first step is to provide an absorbent article having a longitudinal centerline and a transverse centerline perpendicular to the longitudinal centerline. A barrier leg cuff having a first edge and a second edge is provided. At least one of the edges of the barrier cuff is maintained parallel to the longitudinal centerline of the absorbent article. The barrier cuff is then bonded to the absorbent article along a juncture line that extends in a curved configuration with respect to the longitudinal centerline of the absorbent article.
Patent JP-H10504022-A (JP)
Title: 相補的ｄｎａ及びトキシン
IPC: A61K31/7042
Filed: 1995-05-12
Abstract: (57)【要約】
 本発明は、新規な誘導体化された固体支持体及び式（Ｉ）を有する化合物に関する。ここで、Ｓは固体支持体であり、Ｌは化学結合又は適切な無機若しくは有機リンカーであり、Ｚは−ＳＯ 2 −若しくは−Ｓ−Ｓ−であり、Ｒは−ＯＨ、Ｈ−ホスホネート、アルカン−ホスホネート、ホスホトリエステル、ホスファイトトリエステル、ホスファイトジエステル、ホスホロチオエート、ホスホロジチオエート、ホスホロアミデート、ホスホロアミダイト、−ＯＲ 1 、−ＳＲ 1 、ヌクレオチド、Ｎであって、その糖、ホスフェート若しくは塩基で置換若しくは修飾されうるもの、又は式−（Ｎ）ｇ−Ｒ 2 である。但し、Ｎは先に定義したとおりであり、同じでも異なっていてもよく、ｇは１から２００の整数であり、Ｒ 1 は適切な保護基であり、Ｒ 2 はＨ−ホスホネート、アルカン−ホスホネート、ホスホトリエステル、ホスファイトトリエステル、ホスファイトジエステル、ホスホロチオエート、ホスホロジチオエート、ホスホロアミデート、ホスホロアミダイト、−ＯＨ、−ＯＲ 1 、−ＳＲ 1 、又は−Ｏ−Ｐ（ＯＣＨ 2 ＣＨ 2 ＣＮ）−Ｏ−ＣＨ 2 ＣＨ 2 ＺＣＨ 2 ＣＨ 2 ＯＲ 1 でありうる。更に、本発明は、３’−ホスホネートオリゴヌクレオチド、５’−ホスホネートオリゴヌクレオチド、（３’，５’）−ジホスホネートオリゴヌクレオチド、３’−ホスフェートオリゴヌクレオチド複合体、５’−ホスフェートオリゴヌクレオチド複合体、及び（３’，５’）−ジホスフェートオリゴヌクレオチド複合体を製造する方法を提供する。
Patent JP-H10506669-A (JP)
IPC: C04B35/111
Filed: 1996-03-13
Abstract: Seeded sol-gel alumina abrasive grits with improved grinding performance incorporating alkali metal oxides selected from rubidium and cesium oxides.
Patent JP-H11509945-A (JP)
Title: シングル又はダブル並列終端を備えたモジュラー・バス
IPC: G06F12/00
Filed: 1996-04-01
Abstract: (57)【要約】
シングル終端またはダブル終端が可能なモジュラ・バスについて記載する。このバスは、マスタと１つまたは複数のマザーボード装置との間でデータ信号を伝達する終端されたマザーボード・データ網を備える。マザーボード・データ網と取り外し可能モジュールの終端されたモジュール・データ網との間でデータ信号を結合するためにソケットを使用する。モジュール・データ網はマスタと１つまたは複数のモジュール装置との間でデータ信号を伝達する。データ信号振幅とデータ信号の反射レベルはモジュールの存在とは実質的に独立している。
Patent JP-2000513059-A (JP)
IPC: E04G23/02
Filed: 1998-01-20
Abstract: Flat strip lamella for reinforcing weight-carrying or weight-transferring building components. It has a composite structure consisting of a plurality of pliant or loose-flex supporting fibers (26) aligned parallel to each other, and a binding matrix (28) which connects the supporting fibers to each other so that they are shear-resistant, and is fastenable by means of an adhesive (16) by its broad side to the surface of the building component (12) that is to be reinforced. So that the flat strip lamella, to which the binding matrix gives rigid elastic form, can also be bent over corner edges of a building component (12), the invention proposes that the binding matrix (28) be removed, in at least an intermediary area (30), by uncovering the supporting fibers (26), and that the uncovered supporting fibers be subjected to a liquid or pasty thermosetting plastic, in order to stabilize the bent-over condition.
Patent JP-2001500839-A (JP)
IPC: C07K1/20
Filed: 1997-03-07
Abstract: The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprotein which includes this depyrogenation step, and to the depyrogenated product and its clinical uses.
Patent JP-2001511127-A (JP)
Title: （ｚ）−アザビシクロオキシムエーテル類を製造するためのワンポット法
IPC: A61P25/28
Filed: 1997-12-29
Abstract: (57)【要約】
生物学的に活性なＺ配置を有するＯ−置換アザビシクロオキシム類は、酸性水溶液中で１−アザビシクロ−３−オンをＯ−置換ヒドロキシルアミンとカップリングさせ、そして精製または分離を必要とすることなくＥ−配置異性体をＺ−異性体に変換することにより、簡単に、クロマトグラフィー分離を行わないで、そして高収率ならびにＺ／Ｅ純度で単離することができる。中和およびそれに続く遊離塩基の単離、その後の塩の沈殿が、高Ｚ／Ｅ純度のＺ−異性体の分離を可能にする。
Patent JP-2000508286-A (JP)
Title: 炭化水素系供給原料からの合成ガスの製造
IPC: B01J23/74
Filed: 1997-04-01
Abstract: (57)【要約】
メタン及び酸素の混合物から合成ガス（本質的には水素及び一酸化炭素の混合物）を製造する方法であって、該反応ガス混合物を、比較的低温（１００〜９５０℃）で１５バールまでの圧力で所定のニッケル−アルミニウムファイトクネヒト化合物／アルミノシリケート粘土鉱物をベースとする触媒と接触させることによりメタンを部分酸化することを含む該方法。得られた合成ガスは、更に酸素と混合することができ、また、中間圧縮工程に付されることなく、更に部分酸化して、メタノール等の化学製品を製造するための高圧ダウンストリーム方法での直接使用に適する第２の合成ガスを製造することができる。
Patent JP-H11506072-A (JP)
IPC: B65D85/07
Filed: 1996-05-09
Abstract: A tissue package comprising a plurality of tissues and a dispensing package. The plurality of tissues is compressed in two discrete stages, each of which stage can be released independently from the other. The first stage of compression is less than the second stage of compression. The tissues are transported and stored while under the second stage of compression. The user releases the second stage of compression, whereby the tissues can expand up to the first stage of compression. The user releases the first stage of compression just before installing the plurality of tissues into a dispensing package or dispenses the tissues through a restraint while they are held in the first stage compression.
Patent JP-2001500899-A (JP)
IPC: A61K35/32
Filed: 1998-03-11
Abstract: This invention described a novel use for cartilage extract, namely a shark cartilage extract, in a combined anti-tumor therapy. The cartilage extract is used in combination with anti-neoplastics. The combined therapy provides for a higher anti-tumor efficacy with no concomitant increase, even better with a decrease, of toxic side effects.
Patent JP-2001518009-A (JP)
Title: 塗料を自動スプレイ塗布するための装置
IPC: B05B9/04
Filed: 1998-03-23
Abstract: (57)【要約】
スプレイノズルを経て塗料を自動スプレイ塗布するための装置であって、塗料を収容して上記スプレイノズルの近傍に配置され、スプレイ塗布のためスプレイノズルに導管(4)を経て塗料を供給するように接続された容器(5)を有する。この容器は、回転可能に配置され、容器内に収容された塗料を容器の外周域に向け外側へ押し出すべく容器を回転駆動する部材(8)を有する。上記導管は、容器の上記外周域に開口(18)を経て連通する。この開口(18)を経て上記スプレイノズルへ向かって塗料が押し出されるように容器内の圧力媒体に正圧を加える手段が設けられている。
Patent JP-2001510354-A (JP)
Title: アブレーションおよび検知用の医療用カテーテル
IPC: A61B18/12
Filed: 1996-11-08
Abstract: (57)【要約】
ステント使用により生じた閉塞物質の修正可能な電気外科アブレーションによる、焼灼用器具および方法。閉塞された脈管内にカテーテルを挿入、操作し、電磁検知により体内の対象物を検知する。一極以上の電極(14)が装着された電気外科装置(10)がステント(20)内部に留置され、電流が電極(14)に供給され、ステント(20)内および周縁の物質を焼灼除去する。前記装置は超音波トランスジューサ、光ファイバー、インピーダンスセンサーその他をステント内に適切に留置できる。別の特徴として、物質は不均等に焼灼され、その後の隙間(1010)をぬってカテーテルを進行することで、閉塞物質(1060)間で操作される。さらに、装置(2010)は患者の体内に挿入でき、電磁気的に検知可能な体内物質の存在を確認できる。
Patent JP-2000512249-A (JP)
Title: 改良構造の容器
IPC: B65D25/02
Filed: 1999-06-10
Abstract: (57)【要約】
本発明は改良構造の容器に関する。この改良構造は１個の透明な中空容器と、少なくとも１個の円形分割板と、液体および／または固形物を収容する少なくとも１個の貯槽とを包含し、前記透明中空容器が第１端部および第２端部を有し、前記第１端部が更にねじスリーブを有し、前記透明中空容器の第２端部が適当な位置に水取り入れ口を備える。前記透明中空容器の第２端部が前記円形分割板と嵌合され、前記円形分割板の中心に小出し管を入れる孔を有し、該小出し管が前記円形分割板の孔と透明中空容器の第１端部のねじスリーブとの間に配置されている。前記貯槽は透明中空容器の下に嵌合され配置されている。前記透明中空容器は色々の装飾品を有することができ、着色されているか又は透明な水、油、液体が透明中空容器の第２端部に設けた水取り入れ口を通じて透明中空容器に流入されることができ、着色油は水よりも比重が大きいので水の下になる。色々の装飾品を着色剤の上に浮かべて審美的効果を得るようにするため、色々の装飾品の比重を水より大きくし着色剤より小さくしなければならない。更に、前記貯槽はシャンプー、清浄剤またはローションのような洗浄剤を容れることかでき、且つ洗浄剤を小出し管から使用者の手元に押し出すため小出し管の中に流体配送管を配置している。したがって、本発明は実用性と同様に審美的娯楽も提供する。
Patent JP-H08226962-A (JP)
Title: Phased array radar for self-monitoring and calibration
Inventor: HARII KAARU ASUTO
IPC: G01S13/44
Filed: 1989-04-07
Abstract: PURPOSE: To provide a phased array radar device having a new function by using a new combination for maintaining an accurate phase response an a transmission path from an exciter to each antenna element and on a reception path from each antenna element. CONSTITUTION: An exciter 10 sending the signal for correction and transmission, a receiver 11 having a phase error detection circuit on the basis of the exciter 10, and a measurement port, and beam formation instruments 13 and 14 are combined with each other. The beam formation instruments 13 and 14 are provided with m×n/j ports put in transmission/reception operation paths from the exciter 10/receiver 11 to an antenna element 21.  The combination contains cooperation calibration power feeding circuits 15 and 16 which are provided with a single port internally connected to (m×n/i, normally i=4) ports and whose each path has enough electrical length to form a calibration path from each antenna element 21 to the exciter 10/receiser 11, and a plurality of transmission/reception(T/R) part assemblies 20 (m×n/4 pieces), for each subset of four antenna elements, which are put in the transmission and reception operation paths and allow phase adjustment.
Patent MD-20070296-A (MD)
Title: Method for increasing the microwire magnetic resistance on base of solid heterogeneous materials
Inventor: MEGLEI DRAGOS
IPC: H01L21/3215
Filed: 2007-10-31
Abstract: The invention relates to electronics, namely to the magnetic field measuring devices. The method for increasing the microwire magnetic resistance on the basis of solid heterogeneous materials consists in that into a semimetallic or semiconductor material of high elasticity there are introduced impurities of ferromagnetic material in a quality of 16...22%, they are heated up to the melting temperature and are mixed, forming an alloy. The impurities of ferromagnetic material when cooling form a precipitate, which at a low temperature is chemically neutral about the semimetallic or semiconductor material. From the obtained alloy there are manufactured microwires in glass insulation.
Patent MX-162558-A (MX)
Inventor: GUALA PIERGIACOMO
IPC: B65D55/02
Filed: 1985-02-22
Abstract: A bottle closure (1) designed to make apparent any previous opening of a bottle consists of a cap (3) a collar (4) extending coaxially in elongation of the cap and a line of weakness (8) between the cap and the collar. A number of resilient tabs (23) project inwardly from the collar (4) and are arranged close to the line of weakness so that they engage in a circumferential recess (15) made on the inside of the cap (3) in proximity to the line of weakness (8), so that the tabs serve as a bridge across the line of weakness (8). Once the cap (3) has been removed the tabs (23) snap out of the recess (15) and cannot be re-engaged therein, so that a fissure opens up between the cap (3) and the collar indicating that the cap has been removed.
Patent NZ-204422-A (NZ)
Title: (+)-cyanidan-3-ol((+)-catechin)derivatives:pharmaceutical compositions
Inventor: BALLENEGGER M E
IPC: C07D311/62
Filed: 1983-05-31
Abstract: Pharmaceutical preparations containing (+)-cyanidan-3-ol derivatives of the formula Iwherein R' and R" are hydrogen, an unsubstituted or substituted hydrocarbon radical, or heterocyclic radical, halogen, formyl, free or functionally modified carboxyl, free or etherified or esterified hydroxyl, free, etherified or oxidized mercapto, unsubstituted or substituted sulfamoyl, acyl or unsubstituted or substituted amino, where however R' and R" cannot both be hydrogen simultaneously, and R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub>, R<sub>4</sub> and R<sub>5</sub> are each hydrogen or an unsubstituted or substituted hydrocarbon radical, and R<sub>2</sub> and R<sub>3</sub> together can also be an unsubstituted or substituted methylene group, and R<sub>1</sub> also an acyl group or an amidated carboxyl group; and therapeutically applicable salts of these compounds, as well as new compounds of these preparations.These pharmaceutical preparations are particularly valuable for treating liver and venous diseases.
Patent NZ-207313-A (NZ)
Title: Wire stuffing connector cover
Inventor: HUGHES R L
IPC: H01R4/24
Filed: 1984-02-29
Abstract: A one-piece wire stuffing cover having a series of tubular terminal receiving sockets with wire gripping slots at front and rear faces and respective wire stuffers between the slots, lead-out openings for wires terminated by the cover being provided in the sockets rearward of the wire stuffers. The lead-out openings are provided by rebated portions in the sockets which define wire engaging shoulders extending across a rear axial end of the terminal for strain relief. The slots in the rear face diverge progressively to release the wire at the rear face during termination.
Patent NZ-207930-A (NZ)
Title: Preparing base salts of piroxicam
Inventor: NOSEWORTHY M M
IPC: C07D417/12
Filed: 1984-04-19
Abstract: A process has been developed for preparing the sodium, the monoethanolamine and the diethanolamine salts of piroxicam, in which the salt is deposited on a pharmaceutically-acceptable carrier. The compositions so obtained are useful for preparing pharmaceutical dosage forms of piroxicam, from which piroxicam is rapidly absorbed from the gastrointestinal tract after oral administration to mammals. These latter dosage forms are particularly suitable when it is desired to use piroxicam as an analgesic agent, where rapid onset of action is necessary.
Patent NZ-210257-A (NZ)
Title: Production of oligosaccharides and uses thereof
Inventor: LINNETT P E
IPC: A23K10/32
Filed: 1984-11-20
Abstract: Process for the preparation of oligosaccharides-containing products from biomass involving the use of hydrochloric acid for partly hydrolysing biomass to easily fermentable oligosaccharides-containing products and easy recovery of the hydrochloric acid and the oligosaccharides containing products.The oligosaccharides-containing products themselves and use of the latter for the preparation of useful products like ethanol and penicillin by fermentation.
Patent NZ-211160-A (NZ)
Title: 2-(6-hydroxy(or methoxy)-naphth-2-yl)propionic acids
Inventor: VAN MORZE H
IPC: C07C59/88
Filed: 1983-05-26
Abstract: (d)-2-(6-Methoxy-2-naphthyl)propionic acid and pharmaceutically acceptable salts thereof are prepared by resolving mixtures of (d)- and (1)-enantiomers of 2-(6-methoxy-2-naphthyl)propionic precursor acids or salts thereof with N-alkyl- or N-cycloalkyl-D-glucamines or salts thereof to isolate the corresponding (d)-2-(6-methoxy-2-naphthyl)propionic precursor acid which can be readily converted into (d)-2-(6-methoxy-2-naphthyl)propionic acid or a pharmaceutically acceptable salt thereof.
Patent NZ-220403-A (NZ)
Title: Controlled release compositions containing macromolecular polypeptides
Inventor: EPPSTEIN DEBORAH ANN
IPC: A61K9/26
Filed: 1987-05-22
Abstract: An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.
Patent NZ-222590-A (NZ)
Title: Protective sleeve for injection needle
Inventor: PARRY J S
IPC: A61M5/32
Filed: 1987-11-18
Abstract: An accessory for an injection device of the kind in which liquid is drawn or expelled along a hollow needle 9 comprises a protective sleeve 1 for surrounding the needle 9. The sleeve 1 has at least an end portion 11 which is reciprocable in the direction of the length of the needle 9 between an extended position in which the point of the needle 9 is located within the sleeve 1 to shield the point of the needle 9 and a contracted position in which the point of the needle 9 projects from the sleeve 1, to enable an injection to be effected. A retaining arrangement, making use of a pin 19 located within a hooked portion 22 of a track 20, is provided for retaining the sleeve 1 in the extended position after the injection has been effected and preventing the point of the needle 9 from being exposed solely by application of pressure to the end portion 11 of the sleeve 1 in the direction of contracting movement.
Patent NZ-222907-A (NZ)
Title: Preparation for intranasal administration containing a phospholipid absorption enhancing system
Inventor: HANSEN PHILIP EDGAR
IPC: A61K47/24
Filed: 1987-12-14
Abstract: The systemic absorption after intranasal administration of certain drugs, in particular pharmacologically active polypeptides is enhanced in the presence of a phospholipid, such as a phosphalidylcholine (a lecithin), preferably admixed with a vegetable oil.
Patent NZ-224233-A (NZ)
Title: Heterocyclic neophane analogue and biocidal compositions
Inventor: SCHUBERT HANS HERBERT
IPC: C07D237/18
Filed: 1988-04-13
Abstract: Compounds of the formula (I) and their stereoisomers   <IMAGE> (I) wherein A, B, C' and D independently of one another denote CH or N, in which at least one of the symbols A, B, C' or D must correspond to a nitrogen atom, X denotes CH2 or oxygen, R1 denotes a radical bonded to a carbon atom from the series comprising H, trialkylsilyl, halogen, nitro, cyano, alkenyl, alkynyl, amino, cycloalkyl, phenyl, phenxy, alkoxy, alkenyloxy, alkynyloxy, hydroxycarbonyl, alkylthio, cycloalkyloxy, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkoxyalkyl, alkylthioalkyl, alkoxyalkoxy, halogenoalkoxyalkoxy, alkenyloxyalkoxy, halogenoalkenyloxy, alkoxyalkylthio, alkylthioalkoxy, alkylthioalkylthio, halogenoalkoxycarbonyl, halogenoalkenyloxycarbonyl or dialkylamino or two radicals R1 when they are positioned ortho to one another together denote a methylenedioxy, ethylenedioxy or alkylene radical, R2 and R3 independently of one another denote alkyl, alkenyl or phenyl, or R2 and R3 denote an alkylene chain which-together with the quaternary carbon atom-forms an unsubstituted or fluorinesubstituted ring having three to six ring members, R4 denotes -H, F, -CN, -CCl3, -C 3BOND CH, (C1-C4)alkyl, -C-NH2, S R5 denotes pyridyl, furyl or thienyl which can all be substituted, phthalimidyl, dialkylmaleimidyl, thiophthalimidyl, dihydrophthalimidyl, tetrahydrophthalimidyl or substituted phenyl, or R4 and R5-together with the carbon atom bridging them-denote an optionally substituted indanyl, cyclopentenoyl or cyclopentenyl radical and n denotes 0, 1 or 2, possess advantageous properties for combating pests, in particular insects and acarids. Furthermore, processes for the preparation of compounds of the formula I are described.
Patent NZ-227794-A (NZ)
Title: Pharmaceutical compositions comprising arylamido (and arylthioamido) azabicycloalkanes
Inventor: SMITH WILLIAM LEVI
IPC: A61K31/435
Filed: 1989-01-30
Abstract: A method for improving memory or correcting memory deficiency is disclosed, utilizing compounds of the general formula: <CHEM> wherein each of n<1>, n<2>, n<3> and n<4> represent an integer of from zero to 3; each of R<1>, R<2>, R<3>, and R<4> independently represent a hydrogen atom, a loweralkyl or phehnyl group; R<5> represents a hydrogen atom or loweralkyl group; Ar represents a phenyl, substituted phenyl, pyridinyl, furanyl, thienyl, methoxy-1H-benzotriazolyl, indolinyl, methoxyindolinyl, methoxypyrimidinyl, amino-methoxypyrimadinyl, 1,3-benzodioxolyl, or naphthalenyl group; X represents oxygen or sulphur; the optical isomers; and the pharmaceutically acceptable acid addition salts, such as hydrates and alcoholates thereof. The dosage effective for this use is from 10 to 1000 nanograms/kg body weight.