baber/WOPTO huggingface dataset:
Patent EC-SP12012111-A (EC)
Title: Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6
Inventor: LUZZIO MICHAEL JOSEPH
IPC: C07D519/00
Filed: 2012-08-20
Abstract: La invención se refiere a novedosos compuestos de pirrolo-pirimidina de la fórmula (I): (I)en donde R1, R2Y, R4, R8- R11, A y L se definen en la presente, y a las sales, incluyendo las sales farmacéuticamente aceptables de los mismos. Los compuestos de la presente invención son inhibidores de CDK4/6 y podrían ser útiles en el tratamiento de las enfermedades y los trastornos mediados por CDK4/6, tales como cáncer, incluyendo linfoma de células de manto, liposarcoma, cáncer pulmonar no microcelular, melanoma, cáncer esofágico de células escamosas, y cáncer de mama. La invención se refiere además a las composiciones farmacéuticas que comprenden un compuesto de la invención. La invención se refiere todavía adicionalmente a los métodos para inhibir la actividad de CDK4/6, y al tratamiento de los trastornos asociados con la misma, utilizando un compuesto de la invención o una composición farmacéutica que comprenda un compuesto de la invención.
Patent EE-202000001-A (EE)
Title: Modular outdoor furniture system that opens for the position of use and closes for the storage position
Inventor: MURAYENKO OLEKSANDR
IPC: A47B3/14
Filed: 2020-01-06
Abstract: The subject of the invention is a modular outdoor furniture system, which can be folded in for storage or unfolded for use. The piece of furniture consists of four leaf-shaped units 1 with four seats 2 within them. The leaf-shaped units are attached to the platform 3 by hinges 7. The platform 3 holds up a table 9 with a parasol 8. The platform 3 turns around the base 4 horizontally. The base 4 is attached to the ground by anchors 10. The leaf-shaped units 1 along with the seats 2 turn around the hinges 7 in both folded and unfolded positions. The turn is started by the pump 6 and facilitated by hydraulic cylinder 5 attached to the platform 3 and the units 1.
Patent GB-189704414-A (GB)
Title: Improvements in or connected with Boiler Tubes, Steam Pipes and the like.
Inventor: SCOTT THOMAS
Filed: 1897-02-18
Granted: 1898-02-18
Abstract: 4414. Scott, T. Feb. 18. Drawings to Specification. Metal tubes. -Water-tubes for steam boilers, steam pipes, and pipes and tubes for the circulation of fluids in general are constructed in the form of a sheaf or bundle, the intermediate spaces being filled with some suitable good conductor of heat. In some cases, the sheaf or bundle may be enclosed in a case or tube of larger diameter.
Patent GB-189705504-A (GB)
Title: Improvements in or connected with Rudder Fittings.
Inventor: NIXON CHRISTOPHER NUGENT
Filed: 1897-03-02
Granted: 1898-02-26
Abstract: 5504. Nixon, C. N. March 2. Rudders.-A flat-backed tube or gudgeon, fastened to the stem of a boat by straps b<3>, b<4>, is slit longitudinally so that the pintle c, Figs. 7 and 8, and its recessed fittings may be passed therethrough. The fittings c<2>, c' are provided with straps c', c<3> to carry the rudder, which is prevented from rising by a simple hinged lock e. The lower strap b<4> is separate, and forms a step for the recessed fitting c<3>, which is in effect a continuation of the main pintle. In a modified arrangement, the pintle is secured to the sternpost and the tube to the rudder; in a further modification, the tube is dispensed with, and the straps, attached to the boat, are slotted to allow the rudder straps to move past them.
Patent GB-189706972-A (GB)
Title: Improvements in the Manufacture of Spindles, Knobs, or Mounts of Fenders, Bedsteads, and other Furniture.
Inventor: TAYLOR EDWIN
Filed: 1897-03-17
Granted: 1898-03-17
Abstract: 6972. Taylor, E. March 17. Fenders.-A knob, spindle, or mount is stamped in two parts A, B, having flanges a<1>, b<1> or a<2>, b<2>, which are connected by rivets. In Figs. 4 and 5 are shown knobs made in three parts E, F, H, or two parts J, J<1>, flanged and riveted at a<3>. In Fig. 9 is shown a mount made from a single piece bent at its middle to form the top K, the ends only being flanged and riveted. The parts may or may not be covered with thin sheet brass, and wire, wood, &c. may be put between the flanges to form a solid joint.
Patent GB-189709917-A (GB)
Title: Improvements in or relating to Apparatus for Swaging or Rolling Metal Tubes.
Inventor: PRICE BENJAMIN
Filed: 1897-04-20
Granted: 1898-04-16
Abstract: 9917. Price, B., Marsh, C. W. E., and Laybourne, R. April 20. Rolling.-Relates to improvements in the apparatus described in Specification No. 6283, A.D. 1894. Rolling-sectors R or gapped rolls are carried in a housing reciprocated through link mechanism N', N<2>, H<2> by a crank shaft M. The mandrel 0 carrying the ingot W is held in the sleeve A' by a cottar l pressing against the side of the mandrel. While the ingot is grasped and being acted upon by the rolls, the sleeve A' is drawn back in its support B by a cam M', link P<5>, shaft P<3>, and forked piece O<1>, the cottar l sliding along the mandrel. When the ingot is liberated by the rolls, the sleeve A' with the mandrel 0 is fed forward by this cam mechanism, and is also rotated through a right-angle by the cam and link mechanism N<3> connected to the crank A<2> on the sleeve. To ensure the roll grooves always registering, the motion of the rolls is controlled by blocks e on them engaging slots in cross-bars R<2> or by pinions on their axes gearing with fixed racks, or by cranks on their axes connected by pivoted links to fixed points on the machine frame. Instead of the cottar l, other friction gripping-devices permitting slip may be employed to secure the mandrel in the sleeve. The mandrel may be attached to a screwed rod passing through and rotated by the sleeve A<1> to which intermittent rotation is imparted, when the work is released by the rolls, by the cam M' and suitable mechanism. The screwed rod passes through a fixed nut and feeds the metal to the rolls. The feed-mechanism may be operated from the crank shaft M by gearing driving a screw continuously for advancing the support or slide B, a spring being compressed while the rolls are operating and the slide B is prevented from advancing. The sleeve A<1> is then only oscillated in the slide B. The screw for advancing the slide B may be driven intermittently by the worm gearing shown in Fig. 21, in which the worm is formed with partly straight and partly helical grooves on threads.
Patent GB-189717168-A (GB)
Title: Improvements in Brakes for Velocipedes and like Vehicles.
Filed: 1897-07-20
Granted: 1897-09-04
Abstract: 17,168. Lake, H. H., [New Departure Bell Co.]. July 20. Brakes, back-pedalling. The Figures show the invention as applied to a bicycle. A split band C is mounted loosely on the end of the hub X, its ends c, c' abutting against a projecting block a<x>. The chain or other wheel B is also mounted loosely on the hub and provided with a recess for engaging the projection c<6> on the band C. The band C is held in position by a collar A', a', and it is encircled by a fixed drum E, preferably lined with leather e. When the wheel B is rotated forwards it imparts motion to the hub X through the split band C, which rotates clear of the drum E. When the wheel B is retarded by back-pedalling, the split band C is expanded and caused to come into contact with the drum E. The projection C<6> may also engage a notch b<4> formed in a flange a on the hub X. In a modification, which may be applied to existing cycles, the split band is expanded by the action of wedge or cam surfaces on the band and hub end respectively.
Patent GB-189717400-A (GB)
Title: Improved Button.
Inventor: GRUNDMANN ERICH
Filed: 1897-07-23
Granted: 1897-09-18
Abstract: 17,400. Grundmann, E. July 23. Buttons.-A button with a back plate has that plate b stamped to form spirally - disposed curved tongues d alternated by spurs e pointing in the opposite direction. When rotated, the tongues d enter the fabric as screw points.
Patent GB-189719838-A (GB)
Title: An Arrangement for Destroying Offensive Odours or Vapours arising from Manufacturing, cooking, or other causes.
Inventor: THOMPSON HENRY
Filed: 1897-08-28
Granted: 1898-07-30
Abstract: 19,838. Thompson, H. Aug. 28. Drawings to Specification. Cooking-stoves, ventilating ; canopies. - Noxious fumes and gases arising from manufacturing or other operitions, particularly in the cooking of fish, potatoes, and the like, are collected in a hood which surmounts the stove or heating-apparatus and conveyed to the ashpits. The fumes traverse the burning fuel and innocuously pass away with the smoke.
Patent GB-189720064-A (GB)
Title: Improvements in and relating to Colliery Cages and the like.
Inventor: FLETCHER WILLIAM
Filed: 1897-09-01
Granted: 1898-08-20
Abstract: 20,064. Fletcher, W., and Walker, W. E. Sept. 1. Safety suspending-apparatus for colliery cages. At each side of the cage, near the top, two levers A, A' are pivoted. The corresponding ones may be coupled by cross-bars, and each is connected, by a chain F, to the ring of the hoisting-rope. Eyes B, B<1> embrace the guides C, C and move along them as the cage rises and falls. Should the hoisting-rope break, the levers are canted by weights A<2>, or springs, and the eyes grip the guides C, C so that the cage remains suspended. An additional set of gripping-levers may be used at the bottom of the cage.
Patent GB-189721741-A (GB)
Title: An Apparatus for Making Fly Catchers.
Inventor: MILNE OSWALD IVAN
Filed: 1897-09-22
Granted: 1898-09-17
Abstract: 21,741. Milne, O. I. Sept. 22. Coating surfaces with liquids and plastic materials. -Relates to apparatus for coating threads or the like with a sticky material to act as a flycatcher. The sticky material is stored in a collapsable tube A having a neck cut away, as shown at C, and stoppered at the end. A sleeve D, cut away as shown at E and F, slips over the end of the neck and the thread to be coated is then drawn through one of the holes F and through the opening C. The supply of sticky material is maintained by squeezing the tube A.
Patent GB-189722691-A (GB)
Title: A Process of Making Dolls' Heads and other parts of Dolls Unbreakable.
Inventor: VERDIER RODOLPHE
Filed: 1897-10-04
Granted: 1898-08-27
Abstract: 22,691. Verdier, R., and Gutmacher, S. Oct. 4. Dolls.-Relates to the manufacture of unbreakable dolls. Several layers of fabric, of which the inner one may be buckram, and the outer a very fine and close material, are stuck together, and, after moistening, are pressed between a heated mould and die of the shape required. If a head is being formed, it is made in two parts, the face and the back. Each portion has a projecting border of fabric, and the two portions are afterwards secured together in another mould for the whole head, the borders being stuck together, covered over with a strip, and the ridge formed cut off flush. The head is then coated with a solution of gelatine mixed with barium sulphate or similar material, and is afterwards painted, and finally dipped into baths of gelatine, and gelatine mixed with formaldehyde or chrome alum.
Patent GB-189726505-A (GB)
Title: Improvements in Pencil Sharpeners.
Inventor: SHARPE HENRY
Filed: 1897-11-13
Granted: 1898-09-17
Abstract: 26,505. Sharpe, H. Nov. 13. Pencil sharpeners.- The appliance consists of a V-shaped piece of metal a provided with an abrading-surface b of emery or the like. A sharp point may be attached for use in removing the paper strips from 'Blaisdell' pencils.
Patent GB-189727819-A (GB)
Title: Improvements in Motor Velocipedes.
Inventor: DAVY WILLIAM
Filed: 1897-11-26
Granted: 1898-03-05
Abstract: 27,819. Davy, W. Nov. 26. Motor road vehicles.- Relates to means for (1) transmitting power from the motor to the driving- wheels of motor velocipedes, and (2) strengthening the frame tubes which carry the motor &c. A wheel A', Figs. 1 and 2, keyed to the motor shaft A, drives a second wheel C mounted on a shaft which rotates in a bearing F. A chainwheel D, also keyed to the shaft E, is connected by a chain I to the crank sprocket J and the driving - wheel K. The frame tubes are strengthened by encircling them with hollowed bars L, Fig. 6, the ends of which are clamped to the bottom bracket, head tube, &c. Fig. 6 shows a suitable clamp. The bar L is placed over the lug V, and is clamped thereto by the clip W, indiarubber or other packing T, U being first inserted as shown.
Patent GB-189801993-A (GB)
Title: Improvements in Bottle Labelling Machines.
Inventor: PETTEE WILLIAM EDWARD
Filed: 1898-01-25
Granted: 1898-08-20
Abstract: 1993. Pettee, W. E. Jan. 25. Damping and affixing labels.-Relates to a bottlelabelling machine. The labels are held in a holder a, mounted on springs a' in a vertically-movable frame a<6>. The label conveyer H is reciprocated horizontally on guides A<1> by means of cams and slotted links and levers from the main shaft c. Two strips d<3> are adjustably attached to its lower surface, which, during the forward stroke of the conveyer, engage with a roller e<3> in a spring- mounted paste trough e. At the end of the stroke (the position shown) the label holder is moved upwards by the cam-operated lever b, and the top label adheres to the pasted edges of the strips d<2>, the holder being again lowered. During the return stroke, the paste trough is lowered, its frame e<1> being operated by a cam f<3> on a shaft f, driven from the main shaft. At the eud of the return stroke, the conveyer rests under a spring- mounted crosshead u<2> carrying a spring-mounted plate u. A bottle B, Fig. 4, is held against the underside of this plate while the crosshead is moved downwards by cams w<1> and links w. The label is thus gripped between the bottle and a spring-mounted plate n on a vertically-movable frame o, and is detached from the pasting-strips d<3>, between which the bottle passes. The frame o is then moved upwards so that rubber wipers o<2>, pivoted on spring-controlled yokes o<4>, pivoted on the frame o, can wipe the label on to the bottle and attach the pasted ends. During the downward movement of the frame, the wipers turn on their pivots to pass harmlessly over the attached label, their upward movement being controlled by springs o<9>. The bottle may then be removed. The frame o is raised by a lever t pivoted on the shaft f, operated by a cam t<1> of adjustable throw, and falls by its own weight, a rubber buffer c<4> being inserted in a disc on the shaft c to take the shock. An adjustable plate is mounted on the conveyer against which the end of the bottle bears, to ensure the label being correctly applied.
Patent GB-189808156-A (GB)
Title: An Improvement in Lubricators for Cylinders of Gas Motor Engines.
Inventor: HOLT HENRY PERCY
Filed: 1898-04-05
Granted: 1898-05-07
Abstract: 8156. Holt, H. P. April 5. Lubricating gas engines. In Specification No. 10,113, A.D. 1894, a lubricator for gas-engine cylinders is described in which a valve V is operated by a flexible diaphragm D moved by the variation of pressure in the gas-supply pipe. In order to maintain the oil at the same level above the valve, an inner compartment H is provided which is supplied with oil pumped up through the tube K by the reciprocations of the diaphragm.
Patent GB-189808462-A (GB)
Title: An Improved Process of Solidifying Crude and Refined Petroleum and Petroleum Residues.
Inventor: BERNTROP JOHAN CONRAD
Filed: 1898-04-09
Granted: 1899-03-04
Abstract: 8462. Berntrop, J. C., and Hulsebosch, M. L. Q. van L. April 9. Solidifying oils.-Relates to the solidification of petroleum and petroleum residues, the product constituting a fuel. A suitable quantity of resin is dissolved in petroleum or petroleum residues, and the solution is rubbed up with slaked lime, water is added, and the whole may be mixed with powdered coal, coke, peat, or other suitable substance. The lime may be partly replaced by cement.
Patent GB-189810467-A (GB)
Title: Improvements in and connected with Apparatus for Washing Bed Pans.
Inventor: MORRISON ALEXANDER FINDLAY
Filed: 1898-05-07
Granted: 1899-03-11
Abstract: 10,467. Morrison, A. F., and Ingram, M. May 7. Bed pans; sinks. -Relates to auxiliary apparatus for sinks to facilitate the washing of bed-pans. The hot and cold water supply pipes are led to a common outlet to which an arm K is fastened by a universal joint. The pan is suspended from an up-turned rose L, the neck being supported by a V- shaped rest M. A second rose N may also be employed. The sink is fitted with a tubular valve 0, which also serves as an overflow,
Patent GB-189811963-A (GB)
Title: Novel or Improved Portable Apparatus or Appliances for use in Decorating Ceramic-ware.
Inventor: FORESTER HERBERT
Filed: 1898-05-26
Granted: 1899-04-08
Abstract: 11,963. Forester, H. May 26. Pottery, ornamenting. A spray-producer for applying colour, either over or under glaze, consists of a conical sheetmetal pot b, open at the top, and provided with an inclined colour tube d which extends from near the bottom of the pot to beyond the end of a surrounding conical air tube c, a small annular space being left between the two tubes. Air under pressure is supplied to the tube c by a tube a which passes half round the pot ; two such air-supply tubes may be fixed on opposite sides of the pot, and be united at the back, or a single straight tube may be inclined over the pot and enter the top of the conical tube c.
Patent GB-189816167-A (GB)
Title: A New Union Joint for Pipes, Tubes, or other Articles.
Inventor: LINGARD ARTHUR
Filed: 1898-07-25
Granted: 1899-05-13
Abstract: 16,167. Lingard, A., and Peace, H. July 25. Couplings, disconnectible.-Relates to joints for pipes, tubes, and other articles. One form of joint is shown in Fig. 2. Compressible elastic rings or packing-pieces b are enclosed between the ferrule d and the end caps c. In modified forms of the joint, there may be only one large elastic ring, or the end pieces may be screwed externally or may be drawn together by means of nuts and bolts. The joint may be applied to connect a pipe to the bib of a water or like tap.
Patent GB-189816921-A (GB)
Title: Improvements in Coverings for Rollers used in Treating Textile Materials, also for Bobbins, Spools and the like.
Inventor: ECKERSLEY WILLIAM MARTIN
Filed: 1898-08-05
Granted: 1899-07-22
Abstract: 16,921. Eckersley, W. M. Aug. 5. Bobbins, spools, &c. are covered with a layer of xylonite, celluloid, or like substance B, which may be secured at the ends by a plate C, as shown in the Figure, or otherwise.
Patent GB-189818553-A (GB)
Title: Improvements in and relating to Railway-trucks.
Inventor: CAPEWELL GEORGE JOSEPH
Filed: 1898-08-30
Granted: 1898-12-10
Abstract: 18,553. Capewell, G. J. Aug. 30. Axle - trucks or undercarriages for single-rail vehicles. Fig. 3 shows a side elevation, and Fig. 4 an end elevation. Each traction wheel 10 runs on the single rail 1, and carries from its journal a yoke or frame 12. Each frame has recesses 17 at its ends to receive projections 18 from cross-bars 19. These bars carry springs 21 for sunporting the truck proper, which is formed by the side frames 2 and the cross-ties 3, 4, 5, 6. The side frames carry vertical shafts 22 for the guiding-wheels 23, and are slotted at 19 to receive the ends of the cross-bars 19. The car body is pivoted at each end by a king bolt to one of the axle-trucks. In a modification, the oscillation of the truck frame on the wheel frame may be provided for by pivoting the frames together by longitudinal pivots, placed before and behind each traction wheel. In another modification, a single guiding-wheel on each side of the truck is carried by a skeleton frame from the wheel frame. Wheels.-These have a wide tread, as shown at 10, and are provided with a tyre of cushioning- material. In a modification, they are built of two thin flanges bolted together with a ma,s of rubber, leather, or other cushioning-material held between and projecting beyond them. In another modification, each traction wheel is provided with a deep groove, which may or may not form the wearing-surface. Brakes.-Each end of the car is provided with a vertical air cylinder secured to the truck frame and available for pressing a hinged brake shoe down on the track.
Patent GB-189818770-A (GB)
Title: A New or Improved Gas Holder.
Inventor: RILEY WILLIE
Filed: 1898-09-02
Granted: 1899-08-05
Abstract: 18,770. Riley, W., and Kershaw, A. Sept. 2. Gas holders.- A holder for oxygen or other gases is formed with two telescopic concentric cylinders A, B connected by a flexible sleeve C. The inner cylinder A is closed at the bottom, and may contain water for weighting it. The washing - apparatus may be placed in the inner cylinder A, or may be connected to the cylinder B by a tube.
Patent GB-189824737-A (GB)
Title: Improved Machine or Apparatus for Bending Pasteboard, Paper, Cardboard, and the like Without Previous Scoring by Gathering or Puckering it along the line of the Bend.
Inventor: ROSENCRANTZ CARL FRIEDRICH
Filed: 1898-11-23
Granted: 1899-01-14
Abstract: 24,737. Rosencrantz, C. F. Nov. 23. Bending. -Paper, cardboard, and the like are gathered, puckered, or bent so as to form ribs, by means of a plunger c which presses the paper &c. against the edges of a longitudinal slot a<1> formed in a steel or other tube a. The plunger c is formed with bevelled operative edges. A channelled block b supports the tube a, and assists in forcing the edges of the slot together as the plunger descends.
Patent GB-189901186-A (GB)
Title: A Shirt Cuff or Sleeve Holder, applicable also for other Useful Purposes.
Inventor: LEWIS GEORGE
Filed: 1899-01-18
Granted: 1899-12-30
Abstract: 1186. Lewis, G. Jan. 18. Hooks. - A hook A is connected by elastic webbing B, or by a piece of tape, chain, or cord, with the safety-pin C. Fig. 1 shows the apparatus used as a cuff suspender. A modified form of hook is shown in Fig. 2.
Patent GB-189904812-A (GB)
Title: Improvements in Apparatus for Working Railway Brakes.
Inventor: HURMAN JAMES
Filed: 1899-03-04
Granted: 1900-01-06
Abstract: 4812. Hurman, J., and Liley E. March 4 Brakes.-Each brake lever A is provided with an operating-weight M, or a spring, and is extended so as to engage with and be supported by an arm B which is connected by the arms G, F, E to the brake lever arm C of the next wagon. The end arm J is operated from a cylinder L on the locomotive. Upon releasing the end arm J, the whole of the brakes are applied by their weights or springs.
Patent GB-189908521-A (GB)
Title: Improvements in Packing Cylinder Pistons, their Rods, and the like.
Inventor: SAYER ROBERT COOKE
Filed: 1899-04-24
Granted: 1899-10-14
Abstract: 8521. Sayer, R. C. April 24. Pistons; stuffing-boxes.-Comprises piston and stuffing-box packing kept tight by the working pressures used in the cylinder, and also means for lubricating the piston and rod under pressure. Fig. 1 shows the application of the invention to a piston. Fluid is admitted from the pressure side of the piston either by the valve 6 or valve 7 into the space behind the expansible split ring 11 and packing 12. In this space is also an expansible chamber through which lubricant has to pass from an outside reservoir by way of the duct 10 to a peripheral groove 13 in the packing. By this means pressure is put on the lubricant. An alternative method of putting pressure on the lubricant, by means of plungers to which working fluid is admitted through openings in the cylinder walls, is also described. Fig. 2 shows the application of the invention to stuffing-boxes. In this, 106 is the valve, 111 the split ring, 112 the packing, and 113 the groove in the packing.