baber/WOPTO huggingface dataset:
Patent JP-H11506358-A (JP)
IPC: A61B17/22
Filed: 1996-03-07
Abstract: PCT No. PCT/CH96/00085 Sec. 371 Date Sep. 29, 1997 Sec. 102(e) Date Sep. 29, 1997 PCT Filed Mar. 7, 1996 PCT Pub. No. WO96/29941 PCT Pub. Date Oct. 3, 1996The catheter connected to a drive unit has, at its front end a cutting tool which consists of a stator and rotor. Cutting edges arranged on the circumference of the rotor and stator interact in a shearing action. The rotor is an external rotor. The detached deposits are conveyed through a tubular sheath and into a collecting container via a discharge chamber. A rotary catheter of this kind is used for carefully removing blood clots and stenoses from narrowed blood vessels such as arteries and veins.
Patent JP-2000509872-A (JP)
Title: 最適化された結晶方位を有する磁気ヘッドを具えた記録及び／又は再生装置、及び最適化された結晶方位を有する磁気ヘッド
IPC: G11B5/53
Filed: 1998-01-19
Abstract: (57)【要約】
磁気記録担体(6)を走査するよう設けられた少なくとも１つの磁気ヘッド(8.9)を有する記録及び／又は再生装置であり、その磁気ヘッドはリードインコアリム(34)及びリードアウトコアリム(35)を有し、各コアは単結晶フェライトからなり、変換ギャップ(37)を構成する。リードインコアリム(34)はその単結晶フェライトの＜１００＞方向に機械的主方向(39)を有し、この主方向が変換ギャップ(37)に対し鋭角Θ E をなし、リードアウトコアリム(35)はその単結晶フェライトの＜１００＞方向に機械的主方向(41)を有し、この主方向が変換ギャップ(37)に対し第２の鋭角Θ A をなす。このような磁気ヘッド(8.9)において、２つの鋭角Θ E 及びΘ A を磁気テープ(6)と磁気ヘッド(8.9)との相対移動時にフェライト材料が両コアリム(34.35)においてほとんど同一の摩耗率(Ｋ)で均等に摩耗されるように定める。
Patent JP-H10500357-A (JP)
IPC: C02F1/28
Filed: 1995-05-22
Abstract: The invention relates to a process for valorizing a liquid acid effluent containing heavy metals, characterized in that it comprises: (i) removing said heavy metals from said effluent, whereby an aqueous saline solution is obtained, which contains at least 2 % by weight of salts; (ii) concentrating the saline aqueous solution obtained in step (i) by evaporation or electrodialysis so as to obtain an aqueous saline solution containing at least 10 % by weight of salts; (iii) subjecting the aqueous saline solution obtained in step (ii) to an electrodialysis with bipolar membranes or to an electro-electrodialysis, whereby at least one base, at least one acid and a spent saline aqueous solution are recovered, separately; (iv) optionally, recycling the spent saline aqueous solution obtained in step (iii) to step (ii).
Patent JP-2000508872-A (JP)
Title: サービスチャネルを前記サービスチャネルの独立同期フレームで伝送する方法、および対応する伝送システム
IPC: H04J3/06
Filed: 1998-01-29
Abstract: (57)【要約】
本発明はサービスチャネルの独立同期（ＰＬＥＳＩＯＣＨＲＯＮＯＵＳ）フレームにサービスチャネルを挿入するための方法に関する。この方法はまた、フレームの送信機および受信機の間でブロッククロックを伝送することからなり、フレーム内の送信機レベルに、サービスチャネルデータを搬送するための少なくとも一つの場所を確保することからなる。送信機においては、スタートビットと称される所定数ｎ１の同一ビット（Ｄ）を各ブロック（Ｂ）の前に付けるとともに以下の規則を遵守しながら確保場所にサービスチャネルのブロックを挿入する（ｉ）。すなわち残っている場所を埋める必要がない場合には、新しいブロック（Ｂ）に対して段階（ｉ）でプロセスを開始し、残っている場所を埋める必要がある場合には、所定数ｎ２のストップビット（Ｆ）と称される同一ビット（Ｆ）でスタートビット（Ｄ）とは異なるビットを各ブロック（Ｆ）の後ろに付け、新しいブロック（Ｂ）に対して段階（ｉ）でプロセスを開始する。受信機においては、スタートビット（Ｄ）の規則的な出現または、ストップビット（Ｆ）が先行するスタートビット（Ｄ）の規則的な出現を検出し、それによって確保場所におけるブロック（Ｂ）の存在を決定し、確保場所からこれらのブロック（Ｂ）を抽出する。
Patent JP-H11504266-A (JP)
Title: 鋼ストリップ鋳造
IPC: B22D11/06
Filed: 1996-04-29
Abstract: (57)【要約】
双ロール鋳造機中の鋼ストリップの連続鋳造が鋳造ロール（１６）で成される。溶融鋼を供給するのが、ロール間隙から下方に凝固ストリップ（２０）を送給するよう回転される鋳造ロール（１６）間のロール間隙（１０）上方に支持された鋳造溜め（３０）への供給ノズル（１９ｂ）から成る供給システムである。ノズル（１９ｂ）を含む金属供給システムの耐火材から炭素が溶出するのを避けるため、溶融鋼は、マンガン成分が０．２０重量％以上、珪素成分が０．１０重量％以上、アルミニウム成分が０．０１重量％より少なく、硫黄成分が少なくとも０．０２重量％である珪素／マンガンキルド炭素鋼である。鋼の所要硫黄成分は供給システムのタンディッシュ（１８）中の一バッチの鋼に硫化鉄を加えることにより達成することができる。
Patent JP-H11505259-A (JP)
Title: 三成分系共沸組成物
IPC: C10M105/12
Filed: 1996-05-20
Abstract: (57)【要約】
共沸又は共沸混合物様組成物を形成するのに有効な量の１，１，１，２，３，４，４，５，５，５−デカフルオロペンタン、ヘプタン、及びアルコール、例えばメタノール、エタノール、ｎ−プロパノール又はイソプロパノールの共沸又は共沸混合物様組成物が開示される。このような組成物は、清浄剤、冷媒、エアゾール噴射剤、熱伝達媒体、ガス状誘電体、消火剤、ポリオレフィン及びポリウレタン用発泡剤、及びパワーサイクル作動流体として有用である。
Patent JP-2001511871-A (JP)
Title: 回転負荷釣り合わせ機構またはそれに関連する改善
IPC: F16M11/10
Filed: 1997-12-05
Abstract: (57)【要約】
本発明は、回転可能入力部（１９、２２）と、１対の心合わせされた線運動可能出力部（２４、２５）と、前記入力部の回転を最小変位位置と最大変位位置の間において位相が互いに９０°離れている前記出力部のシヌソイド運動に変換する手段（２３）と、前記最小変位位置から離れる出力部の前記振動運動に抵抗を与えるばね手段（２９）とを備える回転釣り合わせ機構に関する。入力部の回転運動を前記２つの出力部の線運動に変換する手段は、固定軸の回りを回転するように取り付けられる回転可能カム（２３）を備え、出力部は、カムの回転軸を通る互いの動作に共通の線運動のために取り付けられ、カムの対向する面でカムと係合する２つのカム従動節（３０）を備え、前記ばね手段（２９）は、各従動節に作用し、従動節をカムに向かって片寄らせ、カムに抵抗を与える。
Patent JP-H11507196-A (JP)
IPC: H04B7/005
Filed: 1997-04-01
Abstract: A system and method for controlling the strength of a shared resource signal transmitted by the satellite transponder in a satellite communications system. The satellite communications system includes a gateway for transmitting communications signals including a shared resource signal, a satellite transponder for relaying the signals to at least one subscriber unit (for example, a phone), and at least one subscriber unit for receiving the signals. The method includes the steps of receiving the shared resource signal, at each subscriber unit, via the satellite transponder; measuring, at each subscriber unit, a signal strength for the received shared resource signal; sending the signal strengths to the gateway; and adjusting the power of the shared resource signal transmitted by the satellite transponder based on the signal strengths.
Patent JP-2000508483-A (JP)
Title: 音響フィードバック補正
IPC: H04R3/02
Filed: 1997-04-02
Abstract: (57)【要約】
ビデオ会議施設には、エコーキャンセル用装置が用意され、そこには適応有限インパルス応答フィルタ（３８）があって、拡声器（３０）への入力信号をサンプルし、その信号に基づいて、マイクロホン（３２）へフィードバックされる信号をモデル化するように動作する。このコエーキャンセル用装置にはさらにコンバイナ（３６）があって、モデルフィードバック信号をマイクロホン出力信号から差引いて補正したマイクロホン出力信号を作るようにしており、またマイクロプロセッサ（４０）があって、補正した及び未補正のマイクロホン出力信号を読み取って、フィルタ（３８）の重み付けに対する更新を計算するようにプログラムされていて、この計算には可変スケーリング因子による乗算が含まれており、この因子はフィードバックされる音の長期間平均パワーを示す第一の値と、フィードバックされる音の短期間平均パワーを示す第２の値との比に従って変るものである。このようにして、他のビデオ会議サイトにおいて不自然な音をもつエコーを生じさせるモデル化した出力信号にある好ましくないゆらぎを低減させている。
Patent JP-2001502785-A (JP)
Title: 可動式ねじ山付き部品付き雄型連結部材
IPC: F16B37/08
Filed: 1998-03-10
Abstract: (57)【要約】
軸（１２）と、軸に沿って動くように取り付けられたスリーブ（２５）と、軸（１２）の回りを囲み、軸に対して内側および外側に向って動くように取り付けられ、組み立てられたねじ山付き部品の外径を有効に変化させるための複数のねじ山付き部品（４０）とを備えた可動式ねじ山付き部品のついた雄型連結部材。スリーブ（２５）とねじ山付き部品（４０）は互いに隣接する面を有しており、スリーブを一方向に移動させることにより、ねじ山付き部品が軸（１２）に向って内側方向に動き、スプリング（２４）がねじ山付き部品を外側方向に付勢するような設計になっている。
Patent JP-2001520653-A (JP)
Title: 精神分裂病の治療法
IPC: C07D453/02
Filed: 1998-04-10
Abstract: (57)【要約】
本発明は、精神分裂病、精神分裂形成疾患、及び精神分裂情動疾患の群中から選択される症状を、化合物Ｉを用いて治療する方法を提供する。
Patent JP-2001527491-A (JP)
Title: ホットメルト接着剤を製造する方法および装置
IPC: B65B63/08
Filed: 1998-03-25
Abstract: (57)【要約】
所定の粘度および限定されたサイズおよび形を有するホットメルト接着剤を提供するステップと、上に気密シールを形成するポリマー収縮ラップでホットメルト接着剤を包むステップとを含む、ホットメルト接着剤塊を包装する方法。包装された接着剤塊は、所定の粘度および限定されたサイズおよび形を有するホットメルト接着剤と、ホットメルト接着剤を包むポリマー収縮ラップフィルムとを含む。ホットメルト接着剤は気密に密封される。
Patent MD-20030086-A (MD)
Title: Wind-driven electric plant
Inventor: POPUŞOI Leonid
IPC: F03D1/02
Filed: 2003-03-19
Abstract: The invention relates to the power engineering and may be used in the wind-driven electric plants.The plant contains a post, onto which there is mounted on bearings a conic frame with the possibility of rotation about the post axis. The frame is coupled with the first pipe-line, provided with a bearing ring with the possibility of rotation about the ring. The first pipe-line, by means of the bearing ring, is coupled with the second one, rigidly fixed onto the post. Behind the outlet cut of the second pipe-line it is installed a generator with blades.
Patent MX-160439-A (MX)
Inventor: COLMAN DEREK ALAN
IPC: B01D17/02
Filed: 1985-08-02
Abstract: A cyclone separator comprises at least a primary portion (1) having generally the form of a volume of revolution having a first and second ends, the diameter of the second end (d<2>) being less than the diameter at said first end (d<1>). The primary portion (1) has at least two portions, an inlet portion being generally adjacent and coaxial to a separating portion. Further, the cyclone separator can have coaxially adjacent secondary and tertiary portions (2, 3) with the tertiary portion remote from the primary portion (1). The cyclone separator includes a single inlet (8) with at least a tangential component at or adjacent to the inlet portion, where the inlet (8) can be in the form of a 360<o> spiral, or a component formed in axial direction to the cyclone, or an inlet giving into a feed channel of involute form. The cyclone separator further includes at least two outlets (4, 10). At least part of the primary portion (1) or secondary portion (2) of the cyclone separator, instead of being frusto-conical may be a volume of revolution whose generator is a continuously curved line. Further, a method of separating oil-water phases using the cyclone separator comprises the phases being at a higher pressure than in each outlet and in the downstream end of the downstream outlet portion (4).
Patent NZ-210757-A (NZ)
Title: Sustained release capsule for rumen
Inventor: ROESCH T J
IPC: A61D7/00
Filed: 1985-01-04
Abstract: A sustained release device for introduction through the esophagus to the reticulorumen of a ruminant has a cylindrical housing containing a body of active drug composition urged by a piston and spring into sealing engagement with a constricted end wall comprising an inwardly extending flange defining a delivery opening, the area of such opening and the composition of the drug matrix controlling the release rate to the rumen. A cylindrical weight is contained within the device and is interfitted with the interior wall of the device and partially enveloped by the spring.
Patent NZ-221557-A (NZ)
Title: Ground smoothing attachment for loader
Inventor: SOLAJA NIKOLA
IPC: E02F3/40
Filed: 1987-08-25
Abstract: The present invention relates to an attachment for a loader, comprising an elongated body member generally in the form of a cylinder having a curved outer surface, a blade extending laterally of the elongated body member and projecting outwardly therefrom, and a frame attached to the curved surface of the elongated body member and being provided with at least one recessed member and at least one eye to enable the attachment to be engaged with and disengaged from a quick release mechanism of the loader, which quick release mechanism is operable from the driving position of the loader, such that when the loader is orientated in a first position the blade is arranged to engage with the ground and when the loader is orientated in a second position the curved outer surface of the body member is arranged to engage with the ground.
Patent NZ-226618-A (NZ)
Title: Dual liquid cartridge dispenser: selective compression member enables one cartridge to be dispensed at a time
Inventor: MALDONADO JOHN ETHAN
IPC: A47K5/12
Filed: 1988-10-19
Abstract: The problem with single cartridge dispensers is that when a maintenance person looks at the liquid level of the cartridge, the fluid may be only slightly above the level indicator window with the result that the cartridge would be completely used up before the maintenance person returns to service the dispenser. Thus, it would be desirable to have two cartridges so that the user can completely exhaust one cartridge and then begin dispensing from the second cartridge. The device (10) employs two cartridges (11a,11b) each having a compressable dispensing pump (25a, 25b). A movable compression member (52) is slidable to a first position adjacent the pump (25b) of a first cartridge (11b) or to a second position adjacent the pump (25a) of the second cartridge (11a) so that fluid from only one cartridge may be dispensed at a time.
Patent NZ-226939-A (NZ)
Title: A non-aqueous microbiocide composition comprising povidone-iodine and a solvent
Inventor: YOSHIAKI NAKAMURA
IPC: A01N25/06
Filed: 1988-11-11
Abstract: A substantially non-aqueous iodine microbicide composition comprising (a) a povidone-iodinein in an amount of from 0.0005% to 1.0% by weight based on the total amount of the compsition, and (b) a solvent comprising a lower alcohol having from 1 to 3 carbon atoms or a mixture of a lower alcohol having from 1 to 3 carbon atoms and a non-hydrated polyhydric alcohol, and an aerosol-type iodine microbicide composition containing the iodine microbicide composition.
Patent NZ-232818-A (NZ)
Title: Spindle which will remove the core from a toilet paper roll and a two roll toilet paper dispenser
Inventor: MORAND MICHEL
IPC: A47K10/32
Filed: 1990-03-07
Abstract: The invention is to a spindle (1) for use in mounting a toilet paper roll thereon, and more particularly, for use in mounting a coil of toilet paper, without the core (5), on the spindle (1). The spindle has a flange (45-47) near its outer end that stops movement of the core (5) as the toilet paper roll is pushed onto the spindle (1) during mounting. Continued pushing of the roll onto the spindle (1) while the core (5) is stopped, strips the coil of paper off the core (5). The coil ends up on the spindle and the core is disposed of.
Patent NZ-235629-A (NZ)
Title: Abrasive fabric loop with knitted fabric underlay
Inventor: PRAHL ERNST
IPC: B24D11/00
Filed: 1990-10-10
Abstract: PCT No. PCT/EP90/01689 Sec. 371 Date Apr. 9, 1992 Sec. 102(e) Date Apr. 9, 1992 PCT Filed Oct. 9, 1990 PCT Pub. No. WO91/05896 PCT Pub. Date May 2, 1991.Flexible abrasive means having an underlay, which comprises a knitted fabric, which consists of a base knitted fabric (1) and at least one layer of warp threads (6) and at least one layer, separated from the latter, of weft threads (5) and includes a strengthening size. In each case a plurality of warp threads (6) per needle space (3) are held next to one another by different binding into the pattern in such a way that they run partly under and partly over the cross threads (4) of the base knitted fabric (1). All of the warp threads of a group of warp threads can be separated from one another by cross threads of this base knitted fabric alternating from the upper side to the underside of this warp thread group. A high dimensional stability of the abrasive means in the directions other than the directions of the warp and weft threads is obtained.
Patent NZ-246568-A (NZ)
Title: Variant polypeptides of human kunitz type protease inhibitor; domain 111 of tissue factor protease inhibitor and compositons thereof
Inventor: NORRIS FANNY
IPC: A61P7/02
Filed: 1993-01-07
Abstract: A variant of human Kunitz-type protease inhibitor domain III of tissue factor protease inhibitor (TFPI), the variant comprising the amino acid sequence (I) wherein X<1> represents H or 1-5 naturally occurring amino acid residues except Cys, X<2>-X<15> each independently represents a naturally occurring amino acid residue, and X<16> represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X<1>-X<16> is different from the corresponding amino acid residue of the native sequence.
Patent NZ-247442-A (NZ)
Title: Improving the wetting, dissolution or dispersion of one or more dithiocarbamate compounds in a liquid and compositions thereof
Inventor: GUO YILI
IPC: C09K23/00
Filed: 1993-04-20
Abstract: New and improved compositions comprising particulates and an effective amount of one or more effective salt(s) to reduce significantly the wetting time and/or the dispersion time of said particulates relative to said time(s) in the absence of said salt(s) have been discovered. Methods for reducing the wetting time of particulates in liquid have also been discovered.
Patent NZ-273141-A (NZ)
Title: Dispensing of multiple fluids simultaneously with quick response venting
Inventor: CORBA ROBERT E
IPC: B05B11/00
Filed: 1994-08-15
Abstract: An apparatus for the simultaneous dispensing of fluids from multiple containers in a pre-determined ratio. The apparatus has a pump, at least two fluid containers, a fluid transfer device including dip tubes to transfer fluid from the containers to the pump, a venting system that prevents the creation of pressure differentials between the containers, and a device to open and close the dip tubes so leakage from the containers can be prevented.
Patent NZ-296765-A (NZ)
Title: 8-cyclohexyl substituted xanthine derivatives and medicaments
Inventor: POLLARD HARVEY B
IPC: A61K38/17
Filed: 1995-11-06
Abstract: The present invention provides a method of identifying CFTR-binding compounds for treating cells having a reduced apical Cl- conductance, such as cystic fibrosis cells. This identification method involves the use of polypeptide I alpha , which constitutes a portion of the CFTR protein. The present invention also provides a method of treating CF cells by contacting cells having a reduced apical Cl- conductance with a therapeutically effective quantity of a compound selected by the present inventive identification method. Preferred compounds for such treatment have little or no affinity for adenosine cell receptors. The present invention provides novel compounds useful in practicing the present inventive method, as well as pharmaceutical compositions containing such compounds.
Patent NZ-331875-A (NZ)
Title: Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs
Inventor: LI HUI-YIN
IPC: A61K31/495
Filed: 1997-03-17
Abstract: rocesses for the preparation of R-'alpha'-propyl-piperonyl amine of formula I and its analogs, such compounds being useful intermediates in the preparation of elastase inhibitors, and intermediates useful for making R-'alpha'-propyl-piperonyl amine are described. Intermediate compounds of formula II, and formula III, are claimed.
Patent NZ-333776-A (NZ)
Title: Method for preparing alpha-chloroboronic acids from mannitol
Inventor: MA PHILIP
IPC: C07F5/02
Filed: 1997-06-30
Abstract: A process for making compounds of Formula (I), wherein X is a leaving group selected from the group Br, Cl, TsO, MsO, and TfO and R is a 1,2-diol.
Patent NZ-334830-A (NZ)
Title: Security device comprising a barrier which is moved from a storage position to a use position, where a cover covers the barrier in the storage position
Inventor: WISE TONY
IPC: E01F13/08
Filed: 1999-03-25
Abstract: Locking pin 11 is used to fix the barrier at a set angle (usually upright) by engaging into a plate 12 of the housing.  To lower the barrier the pin is lifted (typically by grasping the upper "T" handle of the locking pin).
Patent NZ-338027-A (NZ)
Title: Fastener-driving tool having wear guard defining fastener-guiding surface
Inventor: SMOLINSKI DARIUSZ
IPC: B25C1/00
Filed: 1999-09-24
Abstract: In order to guide the leading portion of a strip of collated nails a hinged guide structure 68 has a cover made from a polymeric material with a wear guide 74, 76, typically made of steel.
Patent NZ-503219-A (NZ)
Title: Composite information tracking for portable property items
Inventor: HURSTON RYAN
IPC: G06F17/30
Filed: 2000-03-06
Abstract: A single information item such as the registration plate number attached to a vehicle or other similar official identification of a mobile asset is utilized to query a government provided database such as the Land Transport Safety Authority database, and the combination of information from the first database resulting from the query is utilized to query another government database, such as the Motor Vehicle Security Register or the Personal Property Security Register and also a third database to provide a comprehensive composition of information that includes information not only on the present properties of the asset, but also past properties and inconsistencies in the data recorded about the asset at different times.  The comprehensive composition of information may be compiled into a report form presentation to the user making the initial enquiry using the single information item. An online system functioning as a "police book" to track changes in ownership of motor vehicles between dealers is disclosed.
Patent NZ-508419-A (NZ)
Title: Process for recovering a precious metal from an ore by adding an ionic strength modifier then conducting a leaching process
Inventor: STOYCHEVSKI MICHAEL
IPC: C22B3/12
Filed: 2000-11-24
Abstract: A method of recovering a precious metal from a precious metal ore includes: a) adding a blanking agent such as a hydrocarbon to the ore bearing slurry; b) adding at lest one ionic strength modifier such as sodium hydroxide, sodium cyanide or calcium carbonate to the ore bearing slurry and then c) conducting a metal leaching process.
Patent NZ-508585-A (NZ)
Title: Metabolites of ecteinascidin 743
Inventor: MORALES JOSE J
IPC: C07D411/14
Filed: 1999-05-11
Abstract: Described is the purification and structure elucidation of several products of the metabolism of Ecteinascidin 743 (Et 743) by human cytochrome CYP3A4. These compounds are abbreviated herein as "ETM" followed by a numeric value that represents the approximate molecular weight. The structures of the three ecteinascidin metabolites that have been identified are shown as ETM 305, ETM 204 and ETM 775.  Also described is the use of these metabolites in the manufacture of medicaments for treating cancer.
Patent NZ-508907-A (NZ)
Title: Biomedical polyurethane, its preparation and use
Inventor: SPAANS COENRAAD JAN
IPC: A61L27/50
Filed: 1999-06-04
Abstract: The invention is directed to a novel biomedical polyurethane based on diisocyanate linked polyester polymer and diol components, said diol component having a uniform block-length.
Patent NZ-509831-A (NZ)
Title: Composition for enhancing lipid production, barrier function, hydrogen peroxide neutralization, and moisturization of the skin
Inventor: PAUL HARBHAJAN S
IPC: A61K8/00
Filed: 1999-07-19
Abstract: Increased production of skin lipids, increased barrier function, hydrogen peroxide neutralization, prevention of loss of the natural moisturizing factor from the stratum corneum and moisturization of the skin is provided by a topically applicable composition which includes one or more components selected from the group consisting of branched chain amino acids, derivatives of branched chain amino acids and mixtures thereof, which one or more components are capable of being catabolized in epidermal cells to form lipid precursors for epidermal lipid synthesis. The composition can also include one or more enzyme activators which increase the rate of catabolism of the one or more components.
Patent NZ-511569-A (NZ)
Title: A heterocyclic-substituted thiazolium salts useful for reversing advanced glycosylation cross-links using
Inventor: WAGLE DILIP
IPC: A61P27/02
Filed: 1999-11-10
Abstract: A thiazole derivative has the formula (I) wherein: R1 and R2 are independently hydrogen, an alkyl group that can be substituted by a hydroxy group; Y is -CH2C(=O)R or -CH2-C(=O)NHR'; R and R' are independently an optionally substituted heterocyclic ring group containing 4-10 ring members and 1-3 heteroatoms of oxygen, nitrogen or sulphur other than alkylenedioxyaryl and X is a pharmaceutically acceptable ion provided that R is not furanyl. The compounds are useful for improving the elasticity or reducing wrinkles of skin or for treating kidney damage, blood vasculature damage or damage to an ocular lens
Patent NZ-514523-A (NZ)
Title: Pyrazolobenzodiazepines and pharmaceutical compositions as CDK2 inhibitors
Inventor: LIU JIN-JUN
IPC: C07D243/22
Filed: 2000-04-14
Abstract: Described is the compound of formula I wherein: R1 is hydrogen, -NO2, -CN, -halogen, -OR5, -R6OR7, -COOR7, - CONR8R9, -NR10R11, -NHCOR12, -NHSO2R13, or straight-chained lower alkyl which optionally is substituted by hydroxy and/or halogen; R2 and R4 are each independently hydrogen, -halogen, -NO2, - CF3, or straight chained lower alkyl; R3 is hydrogen, -cycloalkyl, -aryl, -heterocycle, - heteroaryl, -COOR7-CN, -alkenyl,-CONR8R9, -alkynyl, or lower alkyl which optionally is substituted by hydroxy, - OR9, F, and/or aryl; R5 is lower alkyl which optionally is substituted by halogen; R6 is lower alkyl; R7 is hydrogen or lower alkyl; R8 and R9 are each independently hydrogen or lower alkyl which itself optionally are substituted by hydroxy and/or - NH2; alternatively, R8 and R9 may form a 5-or 6-membered heterocycle which optionally is substituted by hydroxy, - NH2, and/or lower alkyl; R10, R11 and R12 are each independently hydrogen or lower alkyl; R13 is lower alkyl which optionally is substituted by halogen and/or -NR14R15; and R14 and R15 are each independently hydrogen or lower alkyl which optionally are substituted halogen, or alternatively,- NR14R15 is a heterocycle; and the pharmaceutically acceptable salts of compounds of formula I. Also described are the compounds of 3 and 5 wherein R1 to R4 are as defined above. The compounds may used as the active ingredient of pharmaceutical compositions for the treatment of breast, colon, lung and prostate tumors.