Patent SG-11202000298V-A (SG)
Title: Antibodies to madcam
Inventor: ANDERSON KARIN
IPC: A61K39/00
Filed: 2018-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo Ho VIII Inv n (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/014572 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT (51) International Patent Classification: CO7K 16/28 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/042052 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 13 July 2018 (13.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/532,809 14 July 2017 (14.07.2017) US (71) Applicant: PFIZER, INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). (72) Inventor: ANDERSON, Karin; c/o Pfizer, Inc., 235 East 42nd Street, New York, NY 10017 (US). (74) Agent: MENDEZ, Julio, J. et al.; Proskauer Rose LLP, One International Place, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (54) Title: ANTIBODIES TO MADCAM (57) : The present disclosure relates to antibodies including human antibodies and antigen- binding portions thereof that specifi- cally bind to MAdCAM, preferably human MAdCAM and that func- tion to inhibit MAdCAM. The disclosure also relates to human an- ti-MAdCAM antibodies and antigen-binding portions thereof. The disclosure also relates to antibodies that are chimeric, bispecific, de- rivatized, single chain antibodies or portions of fusion proteins. The disclosure also relates to isolated heavy and light chain immunoglob- ulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclo- sure also relates to methods of making human anti- MAdCAM an- tibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The disclosure also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The disclosure also relates to transgenic animals or plants comprising nu- clpeic acid molecules of the disclosure. Figure IA Figure 1J r Figure IL Figure IB Figure C [MI Figure 10 Figure IF Figure IC A rir.rr. _w,rerrrrri Figure IR Figure IH