baber/WOPTO huggingface dataset:
Patent DO-P2020000212-A (DO)
Title: ESTIMULADOR DE TREG SELECTIVO RUR20kD-IL-2 Y COMPOSICIONES RELACIONADAS
Inventor: PETER BENEDICT KIRK
IPC: A61P37/00
Filed: 2020-11-19
Abstract: La presente divulgación proporciona composiciones de estimulador de Treg selectivo, que incluyen RUR20kD-IL-2 y composiciones relacionadas, y métodos de uso de estas composiciones, por ejemplo, para tratar enfermedades autoinmunitarias y/u otras afecciones que responden al tratamiento que es eficaz para proporcionar un aumento de las cantidades y la activación de los linfocitos T reguladores sobre los linfocitos T efectores.
Patent DO-P2022000085-A (DO)
Title: Composiciones y métodos para inhibir la expresión del gen alas1
Inventor: WILLIAM QUERBES
IPC: A61P3/00
Filed: 2022-04-19
Abstract: La invención se refiere a composiciones de ácido Pribonucleico bicatenario (dsARN) dirigidas al gen ALAS1 y métodos de uso de tales composiciones de dsARN para alterar (por ejemplo, inhibir) la expresión de ALAS1.
Patent GB-189700245-A (GB)
Title: Improvements in connection with Wheels and Brakes suitable for Autocars and other Vehicles.
Inventor: CARR HENRY SINGLETON
Filed: 1897-01-05
Granted: 1897-12-11
Abstract: 245. Carr, H. S., and Schutt, E. Jan. 5. Brakes.-For preventing skidding and sliding on hard and frosted ground, the brakes consist of one or more pronged shoes or blocks P capable of being brought in contact with the ground.
Patent GB-189702386-A (GB)
Title: Improvements in Grain Weighing Machinery.
Inventor: RICHARDSON HENRY
Filed: 1897-01-29
Granted: 1898-01-29
Abstract: 2386. Richardson, H. Jan. 29. Automatic-feed weighers; stands; feeding-devices. -A portable equi-armed balance scale B is carried in a framing A, and can be fixed in position by a roller L<4> worked from a cam L<2>. The weights are arranged upon a scale-pan C, and at the commencement of weighing have descended so far as to open the cut-off gate F by causing a pin K to push against a link G. As the material continues to fall into the sack, this descends and the gate commences to close, but is prevented from completely cutting off the supply by a projection on the trigger arm L, and the sprinkling feed causes the sack to descend still further until the trigger is upset by a projection upon the scale beam ; the sack is then removed, and another substituted. A device of the kind described in Specification No. 13,925, A.D. 1896, may be fitted to hold the mouth of the sack distended.
Patent GB-189702429-A (GB)
Title: Improvements in and relating to Phonographs.
Inventor: OBELT THEODORE VAN HEEMSTEDE
Filed: 1897-01-29
Granted: 1898-01-01
Abstract: 2429. Obelt, T. van H. Jan. 29. Phonographs are constructed with the mandrel D mounted on an axle, one end of which is provided with a band pulley and also a gear-wheel, so connected to a screw shaft G that it rotates at the same rate as the mandrel D. Two arrangements of the reproducer carrier are described ; one is shown in Fig. 5, in which the shaft G is contained by an open sleeve H, on which a slide J moves. The slide J is provided with a cam K' operated by an arm K for bringing the partial nut in or out of engagement with the shaft G, and for raising and lowering the diaphragm holder J<3> by means of a sliding pin. In a second arrangement, no sleeve H is employed, but a sliding frame has an arm so curved as to carry the diaphragm and the partial nut. This arm may be in two parts, hinged to allow the reproducer to be swung out of the way. Two forms of mandrel are also described, and are preferably employed when the shaft is mounted at one end only. One form consists of a metal cone carrying an outer parallel or slightly-conical cylinder, preferably covered with tape &c., while the second form, for use with metal records, consists of discs or cylinders of wood separated by expanding washers and provided with a screwed shaft and locking winged nut.
Patent GB-189704983-A (GB)
Title: Improvements in Scales or Balances.
Inventor: FANNER WILLIAM CHRISTOPHER
Filed: 1897-02-24
Granted: 1897-03-27
Abstract: 4983. Fanner, W. C., and Elfick, H. Feb. 24. Equi-armed balances.-Relates to the central pivoting of beam scales. The shackle is formed with an open front, and the bearing C, which is in the form of a hollowed-out block, is dovetailed in the shoulder B. The beam is perforated at F so as to fit over the shoulder as shown in Fig. 5, and bring the knife-edge G into the bearing.
Patent GB-189705237-A (GB)
Title: Improvements in the Suspension of Electrical Accumulators or Batteries on Motor Carriages.
Inventor: BROUGHAM REGINALD THOMAS DUDLE
Filed: 1897-02-26
Granted: 1898-02-05
Abstract: 5237. Brougham, R. T. D., and Bersey, W. C. Feb. 26. Motor road vehicles.-Consists of means for resiliently suspending accumulators or batteries on motor carriages in such manner as to prevent undue oscillation and shocks. The box a containing the batteries is suspended from the frame b of the vehicle by links c supported by springs d. Oscillation is checked by the bar e pivoted at one end to the box and at the other end to the frame.
Patent GB-189705525-A (GB)
Title: Improvements in and relating to Apparatus for the Production of Aerated Beverages.
Inventor: RESTALL THOMAS
Filed: 1897-03-02
Granted: 1898-01-08
Abstract: 5525. Restall, T. March 2. Gasogenes and seltzogenes. -The connection between the gas chamber d<1>, Fig. 1, and the aÙrating-chamber d is made through a tube a surrounding the draw-off tube b and provided at its lower end with perforations a<1>. Each chamber d, d<1> has a separate inlet e, e<1>, so that a liquid such as wine may be aÙrated in the lower chamber while water is used to cause an evolution of gas. In order to prevent waste of gas, one of the ingredients, such as tartaric acid, is placed in d<1>, water is added, and the other ingredient, such as sodium bicarbonate, is placed in the tube i attached to the screw cap j, and when the latter is in place the bicarbonate is dislodged by tapping. In the modification shown in Fig. 2, the inlet e<1> is provided with two concentric cylinders l, k having holes l<1>, k<1> in their base. The bicarbonate is placed in the inner cylinder l, and is discharged therefrom when the holes l<1>, k<1> are made to coincide by rotating the cylinders. If the ingredients are made up as cartridges or in any other slowly-dissolving form, the inlet e<1> may be closed by a plain cap.
Patent GB-189707391-A (GB)
Title: Improvements in Rock Drilling Apparatus.
Inventor: DULAIT JULIEN
Filed: 1897-03-22
Granted: 1898-02-05
Abstract: 7391. Dulait, J., and Forget, R. March 22. Rock drills, percussive. The drill spindle A is screwed inside a sleeve F, through which it is turned by a handwheel N for the feed. The sleeve is reciprocated by a spring R and a cam E working against a roller g mounted in the crosshead T on the sleeve. T h e cam is driven through the flywheel, which is constructed in two halves m, m<1> connected together by springs r as shown. Motion is derived from the motor X through a flexible shaft G and bevel gear P. The drilling-apparatus is mounted on trunnions Q on a suitable standard, the trunnions being formed on the sleeve K which encloses the spring R and forms part of the guide for the reciprocating parts. The motor X is mounted universally on a standard on a truck which also carries a support Z, on to which the standard or drill can be tilted for transport. The tool is secured in the spindle by an oval ring M<2>, filling-piece D, and set-screw I. The flexible shaft is constructed of links H shaped at each end into three claws h which engage those on the adjacent links and embrace intermediate balls i. The links are enclosed in a flexible casing.
Patent GB-189711196-A (GB)
Title: Improved Apparatus for Grinding Wire Cards.
Inventor: PALFREYMAN JOHN
Filed: 1897-05-05
Granted: 1898-04-09
Abstract: 11,196. Palfreyman, J., and Briggs, P. May 5. Carding-engines.-I n a Horsfall grinding-apparatus, the grinding-roller e is carried by brackets d which slide upon a bed a fixed upon the frame of the carding-engine. The bracket d is traversed by means of f singlethreaded screw c, the rotation of which is reversed when the grinding-roller reaches the ends of the traverse. Both the grinding-roller and the screw. are driven from the shaft h, the former by means of spur gearing e and the latter by the use of worm gearing and mechanism such as an arrangement of three bevel-wheels, or a double set of spur-wheels, whereby the rotation of the screw may be reversed, the reversing-mechanism being operated by reason of spring stops on the sliding bracket engaging with stops on a longitudinallysliding rod. The shaft of the grinding-roller may be provided with ball bearings.
Patent GB-189716881-A (GB)
Title: Improvements in Diamond Core Drills.
Inventor: WEBSTER HENRY LOW
Filed: 1897-07-16
Granted: 1897-10-30
Abstract: 16,881. Webster, H. L. July 16. Diamond and l i k e t o o l s.-Diamonds or the like are set in diamond drills, by electrically depositing metal around them.
Patent GB-189718647-A (GB)
Title: Improvements in Vibrating Plate Propellers.
Inventor: REYNOLDS ALFRED
Filed: 1897-08-11
Granted: 1898-06-25
Abstract: 18,647. Reynolds, A. Aug. 11. Propelling by vibrating plates.-A reciprocating shaft B carries a paddle F pivoted at H and secured to a slide C by a connecting-rod H<1>. A stop E, working in a slot Dof the bar C, allows the paddle to come into position for the outward working stroke, and on the reversal of the motion, the paddle takes up the position shown in dotted lines in Fig. 1. A second slot D' and pin E', Fig. 2, may be used when the ship is propelled astern, and the feathered blade then lies in an opposite direction. When a forward motion only is required, the slide is dispensed with, and the paddle is mounted on stop hinges.
Patent GB-189723062-A (GB)
Title: Improvements in Gas Governors.
Inventor: FARMER DAVID J
Filed: 1897-10-07
Granted: 1898-09-10
Abstract: 23,062. Farmer, D. J., and Farmer, S. Oct. 7. Governors. - In a gas governor of the float type the valve is supported by chains or flexible arms E which are connected on the one hand to a sleeve F on the stem, and on the other to a cylinder D fitting into the central compartment B. The valve G<1> has a ball- and-socket connection with its stem, so as to ensure adjustment to its seat. A weighted lever I, capable of being adjusted by a movable carriage J actuated by a screw K, bears upon the upper end of the valve stem for determining the amount of pressure required to lift the float.
Patent GB-189725412-A (GB)
Title: Improvements in Electrical Resistances.
Inventor: GAMBRELL THOMAS EDWARD
Filed: 1897-11-02
Granted: 1898-10-08
Abstract: 25,412. Gambrell, T. E., and Harris, A. F. Nov. 2. Resistances are made by applying finely-divided carbon, mixed with a binding-material, such as shellac or size, and a volatile solvent, such as methylated spirit or acetone, to solid insulators of ground glass, celluloid, ebonite, or other material. Such a resistance may be mounted in a case, with terminals.
Patent GB-189727651-A (GB)
Title: Improvements in or relating to the Manufacture of Linoleum, Kamptulicon, and similar Materials.
Inventor: KLIETSCH KARL
Filed: 1897-11-24
Granted: 1898-02-05
Abstract: 27,651. Klietsch, K. Nov. 24. Embossing.-Linoleum, kamptulicon, and like materials are embossed by passing them between rollers &c. while in a soft state. The design produced in intaglio is filled in with colour or dye either before or after drying. Alternatively, the colour may be applied by the roller or block which effects the embossing.
Patent GB-189804099-A (GB)
Title: Improvements in Stop Mechanism for Cutting or Turning Machines.
Filed: 1898-02-18
Granted: 1898-12-17
Abstract: 4099. Hoffmann Manufacturing Co. and Hoffmann. E. G. Feb. 18. Lathes; gearing, driving.-A stop motion is provided in an automatic lathe for cutting balls from wire, or in a machine having a cutter a<2>, Fig. 1, advanced against a rotating body so that the machine will be stopped should the cutter become dull and not reduce the balls to the required diameter, or should the wire come to an end, or under other abnormal conditions. The cutter slide a<1> is operated by a lever a, rod b, and lever b<2> from a cam b<1>. The lower end of the lever a is slotted to receive trunnions d on a casing c, the trunnions being held in place by inserting sleeves e endwise. The casing receives one end of the rod b which has a shoulder bearing against a spring c' held and adjusted by a cap m and nut n. A pin g passes through the trunnions and through a slot in the rod, and is held in place by a second pin h passing through a cam slot k in the rod. Under normal conditions, the parts move as shown in Fig. 3, one end of the slot being forced by the spring c' against the pin g. In this position, when the rod and casing reciprocate, the pin g clears a bead o<1> on an arm o, carried on a rock shaft p. Should extra pressure be thrown on the spring c<1> by any abnormal conditions, the spring is compressed and the pin g projected by the cam slot to strike the head o', rocking the shaft p which stops the machine by operating a belt fork or friction clutch. To ensure the machine being stopped should the retardation occur only just before the cutter has completed its feed stroke, a projection b<x> is formed on the cam. Normally this projection only moves the pin g after it has cleared (to the left) the head o', the pin being withdrawn by the spring c' before the casing c returns. A micrometer adjustment may be used on the block to make it more sensitive for small variations of diameter. When the wire gives out, it ceases to be held by the chuck &c., and the cutter is advanced against a non-rotating wire, thus stopping the machine. The pin h can be removed by a cap l, and the remaining parts easily removed.
Patent GB-189804678-A (GB)
Title: Improvements in Insulation of Wire for Electrical Purposes.
Inventor: HEARSON CHARLES EDWARD
Filed: 1898-02-25
Granted: 1899-01-07
Abstract: 4678. Hearson, C. E. Feb. 25. Insulating - compositions.- Conductors are insulated with a solution of celluloid or pyroxylin with colouring-matter, such as cobalt blue, or other suitable material in powder form.
Patent GB-189804946-A (GB)
Title: Improvements in or relating to Illuminated Advertising Mediums or Devices.
Inventor: COX HARRY WILLIAM
Filed: 1898-03-01
Granted: 1899-02-25
Abstract: 4946. Cox, H. W. March 1. Advertising.-Electric lamps are arranged in groups, as shown in Fig. 5, and some are lighted to form letters, the invention relating to the manner in which the particular lamps are selected or lighted. One set of contacts is carried on blocks k, the other set, which makes contact with the first to complete the circuit, consisting of fingers b carried on cylinders c. The fingers b are pivoted to rods g, and are limited in their upward and downward movement by rods h. The fingers which are to be thrown out of action are lifted, and a rod i thrust between them and the others on the rod g. The cylinders are intermittently rotated by cam and ratchet gearing.
Patent GB-189811789-A (GB)
Title: Improvements in Tentering Machines.
Inventor: GADD CHARLES JOSEPH
Filed: 1898-05-24
Granted: 1898-11-12
Abstract: 11,789. Gadd, C. J. May 24. Stretching and tentering.-The frames A which carry the tentering-chains or clamps are oscillated longitudinally, while the chains are moved at a constant rate of speed. The frames A are mounted on pins G, which are journalled on the shaft or axis g concentric with the oscillating rotary shaft B. The shaft B, which actuates the chains through the bevel gearing E, F, is mounted on a pivoted frame C, and is oscillated by a cam 0 which engages with a frame P on the end of the shaft. The cam is adapted to be adjusted to vary the oscillation. The cam shaft and the shaft B are rotated by the main shaft J through gearing as shown.
Patent GB-189820982-A (GB)
Title: An Improved Barrel or Cask Racking Apparatus.
Inventor: MARSHALL JAMES JOHN
Filed: 1898-10-05
Granted: 1899-04-08
Abstract: 20,982. Marshall, J. J. Oct. 5. Filling with liquids.- Racking - apparatus f o r casks consists of a tube A, which is adapted to enter the bunghole of the cask, the tube having an inlet opening A<1>, in connection with the reservoir. The tube has a seat C' for the ball valve C, which, while the cask is being tilled, is held in an angular extension B of the tube. At the side of the tube A is a compartment, for a float D, the lower part of which is in communication with the tube by perforations F. At the top of the apparatus is a vent chamber H having a seating I' at the top for a ball valve I which normally rests on a wire cage H<1>. When the liquid rises in the cask so as to pass through the perforations F, the float is raised, and the ball C, which was held by an extension D' of the float, falls to the seating C'. The liquid, thus shut off from the cask, rises in the tube A until it presses the valve I against the seating I<1>, thus closing the vent opening, and stopping the flow of liquid. The reservoir cock is then turned off, and the apparatus is disconnected from the reservoir. The liquid in the apparatus is allowed to flow into the cask by lifting the ball valve C by means of a trigger C<2>. In modifications, a portion of the extension tube B is cut away, and a hinged weighted valve replaces the ball valve C.
Patent GB-189823217-A (GB)
Title: Improvements in Cigarette Boxes.
Inventor: NEWTON PHILIP ARTHUR
Filed: 1898-11-04
Granted: 1898-12-10
Abstract: 23,217. Newton, P. A., [American Tobacco Co.]. Nov. 4. Cigarette boxes.-Cigarette boxes having a hinged cover B are provided with a hinged side a<1> to enable the cigarettes to be easily removed when the cover is opened.
Patent GB-189901196-A (GB)
Title: Improvements in Horse Shoe Pads.
Inventor: LAYCOCK WILLIAM SAMUEL
Filed: 1899-01-18
Granted: 1899-11-18
Abstract: 1196. Laycock, W. S. Jan. 18. Hoof pads.-A rubber &c. block R with ventilation holes P is fixed to two or more sheets of hair fabric HF, which covers the under face of the hoof and at its edges comes between the hoof and the shoe. Beneath this fabric is a cushion CH of loosely-woven or looped curled hair. The rubber block projects beyond the wearing-face of the shoe, and has grooves at S to protect the stitching.
Patent GB-189904694-A (GB)
Title: Improvements in Wire Drawing Machines.
Inventor: COWLES CHARLES ABERNETHY
Filed: 1899-03-03
Granted: 1899-07-15
Abstract: 4694. Cowles, C. A. March 3. Drawing.-A continuous wire-drawing machine has duplicate sets of drawing-rolls C<1> C' interposed between dies held in boxes or die-holders B', B<2>. The boxes swivel and may slide rearwardly to allow the coils on the rolls to expand and slip when drawing is temporarily suspended. The die is mounted in the front division of the box, the rear division containing a lubricating or cooling liquid. The liquid circulates through pipes c<27>, c<19>, casings and hoods c<20> round the rolls, and passages in the rolls. The rolls are driven at the required speeds by gearing c<1>, c<2> from a central shaft c<7>. Reels or winding-drums F, Fig. 7, are mounted on and rotate with blocks F<1> driven through clutch gearing from the central shaft, the drawing and winding being stopped by disengaging the clutch without stopping the rolls. The reel is suspended by a swivel hook f<10>, which, when locked in contact with the head f by lugs f<12>, causes a sleeve f<8> to hold braces f in a horizontal position, bracing the legs f<2> during winding. The reels, when filled, are lifted by hooks j<10> on bars J carried by turntables J<1> on a hydraulic elevator K, allowing them to be exchanged for empty reels on tables L. These tables have slots l<3> allowing the coil to be tied or bound up before the reel is collapsed. The reel may be collapsed to release the coil, by disengaging the swivel f<11> and moving the sleeve f<8> upwards as shown in Fig. 7. Or the filled reel may be transferred to a hand-truck with a central pillar carrying a revoluble table, so that the wire can be unwound as required
Patent GB-189907479-A (GB)
Title: Improvements in Secondary Batteries.
Inventor: JUSTICE PHILIP MIDDLETON
Filed: 1899-04-10
Granted: 1900-03-24
Abstract: 7479. Justice, P. M., [Preiss Electric Storage Syndicate]. April 10. Secondary batteries.-The positive plates are preferably made of lead, and covered with woollen or other absorbent material, and are formed in the usual way, the woollen covering serving to absorb a quantity of the electrolyte. One or more such plates are taken from the charging-cell and used in combination with a single negative conductor or plate which is in the form of a casing of zinc adapted to contain the positive plates.
Patent GB-189909239-A (GB)
Title: Improvements in Direct Acting Engines, the Invention being particularly adapted to Pneumatic Hammers.
Inventor: KIMMAN HENRY JAMES
Filed: 1899-05-02
Granted: 1899-07-01
Abstract: 9239. Kimman, H. J., and Hurley, E. N. May 2. Locking nuts.-Relates to the locking of a certain screwed sleeve employed in direct-acting compressed-air engines, especially adapted for pneumatic hammers or percussive chisels, caulking-implements, or the like. The cylinder is connected to the handle block by a coupling- sleeve, which is locked to the handle block by a screw J. The screw J is lodged in a pocket in the handle block, as shown in Fig. 5, and engages with worm teeth in the sleeve.
Patent GB-189912066-A (GB)
Title: Improvements in the Manufacture or Production of Metallic Oxides.
Inventor: JOHNSON JAMES YATE
Filed: 1899-06-09
Granted: 1900-04-07
Abstract: 12,066. Johnson, J. Y., [Schroeder & Stadelmann]. June 9. Oxides, metallic.-Ferric oxide, or other metallic oxide, such as that of nickel, copper, or cobalt, is prepared from the corresponding sulphate by highly compressing the sulphate into blocks or bricks, allowing them to harden in dry air until they emit a ringing sound when struck, and finally roasting them in a blast furnace at a temperature between 600‹ and 1300‹ C. At first water of crystallization, and afterwards oxides of sulphur, are eliminated. The shade of colour obtained, in the case of ferric oxide, varies with the temperature of the furnace.
Patent GB-189914751-A (GB)
Title: Garment Suspender.
Inventor: HEYL HEINRICH
Filed: 1899-07-18
Granted: 1899-08-19
Abstract: 14,751. Heyl, H. July 18. Suspenders for articles of dress.-Relates to an appliance for hanging up garments, and especially long garments. It consists of two padded jaws p, p<1>, pivoted together at d and to a lazy-tongs device a h so that, when the appliance is hung up by the loop o, the weight of the garment placed between the jaws will close the clip.
Patent GB-189920875-A (GB)
Title: A New or Improved Machine for Cutting Thistles and other like Weeds.
Inventor: SUTHERLAND WILLIAM
Filed: 1899-10-18
Granted: 1900-10-18
Abstract: 20,875. Sutherland, W. Oct. 18. Thistle-cutting machines.-Relates to a machine for cutting off the heads of thistles and similar weeds. Fig. 2 shows the machine in rear elevation. A frame A, carried on wheels, supports a rotary shaft C mounted in bearings in standards D and actuated by chain gearing from one of the carrying-wheels. A number of adjustable arms a, secured to the shaft C, carry horizontal knives b which work in conjunction with a stationary bar H carried by adjustable arms c, c, to remove the thistle heads.
Patent GB-189924613-A (GB)
Title: Improvements in Pen Holders.
Inventor: CROCKER SAMUEL HENRY
Filed: 1899-12-11
Granted: 1900-12-08
Abstract: 24,613. Crocker, S. H. Dec. 11. Pens and penholders.- The nib C is secured on the outside of the barrel A by spring pieces B, so that it may be removed by applying pressure to the point. The Provisional Specification also describes a modification in which the spring pieces are formed on the inner side of the barrel.