baber/WOPTO huggingface dataset:
Patent IL-79085-A0 (IL)
Title: Hybrid interferons,their preparation and pharmaceutical compositions containing them
IPC: A61P31/12
Filed: 1986-06-10
Abstract: Novel hybrid interferons are produced which are derived from lymphoblastoid interferons a-2 and a-3 belonging to the interferon aB and αD groups, respectively. The novel hybrid interferons possess valuable antiviral and antiproliferative properties.
Patent IL-79465-A0 (IL)
Title: Androstane derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61P15/00
Filed: 1986-07-21
Abstract: 6-Substituted androsta-1,4-diene-3,17-dione derivatives of formula (I) 
<CHEM>
 wherein
 R is (1) the group-N3;
 (2) a group 
<CHEM>
 wherein each of r1 and R2 is, independently, hydrogen or unsaturated C1-C22 alkyl;
 (3) a group -NHCOR3 wherein R3 is
 (a) hydrogen;
 (b) C1-C3 alkoxy or carboxy;
 (c) C1-C22 alkyl either unsubstituted or substituted by a carboxy group; or
 (d) a group 
<CHEM>
 wherein R1 and R2 are as defined above; or
 (4) a group -NHSO2R4 wherein R4 is unsubstituted C1-C4 alkyl, or phenyl either unsubstituted or substituted by C1-C3 alkyl, halogen or nitro;
 and the pharmaceutically acceptable salts thereof are aromatase inhibitors and can be used, e.g. in the treatment of hormone-dependent tumors.
Patent IL-80979-A0 (IL)
Title: Preparation of(2,2)-paracyclophane derivatives
IPC: C07B61/00
Filed: 1986-12-15
Abstract: A process for the preparation of (2,2)-paracyclophane or derivatives thereof by Hofmann elimination of p.-methylbenzyltrimethylammonium hydroxide or derivatives thereof, in an aqueous solution of an alkali metal hydroxide, wherein said elimination is carried out in the presence of a ketone of formula:
 CH3 - CO - CH2 - R      (I)
 wherein R is hydrogen, a halogen or an alkyl-carboxylic group.
Patent IL-84436-A0 (IL)
Title: Plant culturing method and apparatus
IPC: A01G9/24
Filed: 1987-11-11
Abstract: Vegetal plants are cultured on a plant growth interface (11) including a membrane (10) that is permeable to an aqueous plant nutrient medium (12) but impermeable to plant roots and rootlets (151, 171, 191) and is made of a substantially water-insoluble and non-biodegradeable material; the interface means (11) has a plant contact surface (110) for directing roots and rootlets into a substantially superfacial distribution; the membrane (10) forms at least a portion of an enclosure (18) and has (a) a first or root-side surface that constitutes the contact surface (110) or is adjacent thereto, and (b) a second or root-opposed surface (102) exposed to the aqueous plant nutrient medium; plant germinating means (13, 15) in the form of seeds or seedling plants are arranged on the plant contact surface (110); the second surface (102) of the membrane (10) is maintained in contact with the aqueous medium (12) in liquid phase to induce formation of the superfacial distribution; the germinating means (13, 15) are allowed to grow into plants (17) of a predetermined stage of maturation on the interface means (11) and the plants (17) are separated from the interface means (11). An apparatus for carrying out this method comprises an interface means (11) that includes, or consists of, the membrane (10) and forms at least a part of an enclosure (18) for the aqueous medium (12). The invention is of advantage when water and/or heat are limiting factors or when improved plant culture control methods are needed.
Patent IL-88122-A0 (IL)
Title: Heterocyclic derivatives and pharmaceutical compositions containing them
IPC: A61K31/41
Filed: 1988-10-21
Abstract: The present invention is concerned with compounds of formula (I) <CHEM>  wherein R, R<1> and R<2> are independently selected from hydrogen and C1-4 alkyl; R<3> and R<4> are independently selected from hydrogen, C1-6 alkyl (including cycloalkyl) and aryl (wherein the alkyl or aryl group, which latter includes benzyl, is optionally substituted by one or more atoms or groups independently selected from halogen, C1-4 alkyl and aryl), provided R<3> NOTEQUAL benzyl or substituted benzyl when R<4> = H;  m is an integer of from 0 to 2;  n is an integer of from 0 to 3;  (W) is a group of formula (i), (ii), (iii), or (iv) <CHEM> wherein Y is selected from oxygen, methylene and @N-R<5>, where R<5> is hydrogen, C1-4 alkyl, or benzyl, Z and Z min  are independently selected from @C=O, @C-S and methylene, and the chiral centre * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions;  X is a group selected from    aryl (including heteroaryl)  xanthenyl  dibenzofuranyl   which group is optionally substituted by an atom or group selected from    C1-6 alkyl (including cycloalkyl)  aryl (including heteroaryl)  C1-4 alkoxy  aryloxy  alkylsulphonyl  arylsulphonyl  halogen  cyano  carbamoyl  alkylcarbamoyl  dialkylcarbamoyl  arylcarbamoyl  diarylcarbamoyl  carbamoylmethyl  N-alkylcarbamoylmethyl  N,N-dialkylcarbamoylmethyl  N-arylcarbamoylmethyl  N,N-diarylcarbamoylmethyl  alkoylamino  aroylamino  alkoylaminomethyl  aroylaminomethyl  alkylsulphamino  arylsulphamino  alkylsulphaminomethyl  arylsulphaminomethyl  sulphamyl  alkylsulphamyl  dialkylsulphamyl  arylsulphamyl  diarysulphamyl   the aryl group(s) of aryl-containing substituents being optionally substituted by halogen or C1-4 alkoxy; and salts and solvates thereof, the preparation of these compounds, pharmaceutical formulations containing them and their use in medicine, particularly in the treatment of migraine.
Patent IL-91541-A0 (IL)
Title: Aryloxy-,arylthio-,heteroaryloxy-,and heteroarylthioalkenylene derivatives of amines,their preparation and pharmaceutical compositions containing them
IPC: C07D207/335
Filed: 1989-09-06
Abstract: Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula   <CHEM>  wherein each of A and B is a group of formula (i) to (iii): <CHEM> wherein Y is -O-, -S- or -NR- in which R is hydrogen or C1-C6 alkyl; each of R3, R4, R5 and R6 is independently:     a) hydrogen, halogen, hydroxy, cyano or nitro;   b) C1-C6 alkyl unsubstituted or substituted by halogen,   c) C1-C6 alkoxy or C1-C6 alkylthio;   d) C1-C6 alkyl-sulfonyl;   e) a substituted amine group -NR7R8;   f) a -COR12 group; or g) two adjacent groups of R3, R4, R5 and R6, taken together, form a C1-C4 alkylenedioxy group; each of R1 and R2 independently is hydrogen, C3-C6 alkynyl, C3-C6 alkenyl or C1-C6 alkyl unsubstituted or substituted by phenyl; or R1 and R2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepresssant, antiobesity antismoking and anti-alcoholabuse agents.
Patent IL-93051-A0 (IL)
Title: ((5-oxo-2-pyrrolidinyl)methyl)cyclohexaneacetamides,their preparation and pharmaceutical compositions containing them
IPC: A61K31/40
Filed: 1990-01-15
Abstract: [(5-Oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula   <CHEM> wherein R1 is hydrogen, lower alkyl or aryl-lower alkyl; R2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, <CHEM> wherein R5 and R6 are hydrogen, lower alkyl or aryl-lower alkyl; R3 and R4, independently, are hydrogen, lower alkyl or aryl-lower alkyl;  and enantiomers, diastereomers, and racemates thereof, and, when R2 <CHEM> pharmaceutically acceptable acid addition salts thereof exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age-associated memory impairment.
Patent FI-20030939-A0 (FI)
Inventor: NURMELA JUHANI
IPC: B65G1/04
Filed: 2003-06-24
Abstract: The apparatus has a roll manipulator (1) equipped with an overhead support and an operating assembly (1a) for handling roll goods e.g. rolls of paper. A storage depot (2) intermediately stores the roll goods on a base. The roll manipulator handles each roll specimen in conjunction with the storage depot by pushing the roll specimen in a controlled fashion along the base to and/or from a desired laydown spot (2x).
Patent IL-103189-A0 (IL)
Title: Pharmaceutical compositions for treating immunoinflammatory diseases
IPC: A61K31/435
Filed: 1992-09-16
Abstract: Use of rapamycin (I) opt. in combination with cyclosporin A for mfr. of a medicament for treating immunoinflammatory skin or bowel diseases in mammals is new. Pref. the medicament is adapted for oral, parenteral, intranasal, intrabronchial, topical, transdermal or rectal admin. The medicament is in unit dosage form, each unit contg. 0.001-100 pref. 0.1-50 esp. 0.3-25 mg/kg (I).
Patent IL-105042-A0 (IL)
Title: Substituted pyrimidines,processes for their preparation,and their use as pesticides and fungicides
IPC: A01P7/02
Filed: 1993-03-12
Abstract: The invention relates to compounds of the formula defined in the description, X is NH or oxygen and E is a bond or a 1- to 4-membered carbon chain, to a process for their preparation, to agents containing them, and to their use in the control of pests and as fungicides.
Patent IL-110118-A0 (IL)
Title: Ceramic-like materials, and their preparation
IPC: C08L67/06
Filed: 1994-06-24
Abstract: PCT No. PCT/PL93/00012 Sec. 371 Date Dec. 18, 1995 Sec. 102(e) Date Dec. 18, 1995 PCT Filed Aug. 12, 1993 PCT Pub. No. WO95/00583 PCT Pub. Date Jan. 5, 1995This invention relates to a process for preparing ceramic-like materials with specific properties by binding an inorganic filler in the form of a dry composition with a grain size of up to 25  mu m containing in the volume ratio 1:0.-1.52 a waste phosphogypsum and magnetite or glass-forming oxides, with an unsaturated polyester resin in an amount of 46-220 volume parts per 100 volume parts of the filler. The use of magnetite makes it poisible to prepare materials with magnetic properties, while glass-foming oxides enable preparing materials effective to absorb an X-radiation of 45-55 keV and a hard radiation of 0.6-125 MeV. When an expanding agent is added to the raw composition according to this invention, an expanded material is obtained, having completely closed pores, particularly useful in the building industry. The resultant ceramic-like materials are characterized by good adhesion to metals, plastics, glass, wood, concrete and can be easily joined with them both at the stage of polymerization and after its termination by using a prepolymerized resin as a binder.
Patent IL-111481-A0 (IL)
Title: Packaging arrangement for contact lenses
IPC: B65D77/04
Filed: 1994-11-01
Abstract: A packaging arrangement for the containment of at least one hydrophilic contact lens in a sterile aqueous solution. More specifically, pursuant to the packaging arrangement, a plurality of disposable hydrophilic contact lenses are contained in a specific number of individual packaging arrangements (30) collectively housed in a box-like container or carton (10) so as to provide a specified or essentially measured supply of contact lenses for use by a consumer over a predetermined period of time. <IMAGE>
Patent IL-123385-A0 (IL)
Title: Symmetrical bis-heteroarylmethoxy phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
IPC: C07D215/18
Filed: 1996-09-25
Abstract: Compounds having the formula:   <IMAGE>   wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
Patent IL-125856-A0 (IL)
Title: Camptothecin derivatives and the use thereof as antitumor agents
IPC: A61K31/00
Filed: 1997-02-19
Abstract: PCT No. PCT/EP97/00786 Sec. 371 Date Aug. 20, 1998 Sec. 102(e) Date Aug. 20, 1998 PCT Filed Feb. 19, 1997 PCT Pub. No. WO97/31003 PCT Pub. Date Aug. 28, 199720S-Camptothecin derivatives in which the 7-position bears as a substituent -CN, -CH(CN)R4, -CH=C(CN)R4, -C(=NOH)NH2, -C(=NH)NH2, -CH=C(NO2)R4, -CH(CN)R5, -CH(CH2NO2)R5, tetrazol-5-yl, 4,5-dihydrooxazol-2-yl, or 1,2,4-oxadiazolin-3-yl-5-one. These compounds are active as topoisomerase I inhibitors, and can be used as antitumor drugs.
Patent IL-129482-A0 (IL)
Title: Method of enhancing the delivery of growth factors
IPC: A61K38/22
Filed: 1997-08-19
Abstract: The diffusion of a growth factor into and around the brain is enhanced by co-infusion with the growth factor receptor. This allows the factor to exert its biological influence over a broader range of tissue. In specific embodiments, BDNF diffusion is enhanced by co-administration of soluble trkB receptor.
Patent IL-136668-A0 (IL)
Title: Restin and methods of use thereof
IPC: A61K35/407
Filed: 1998-12-08
Abstract: Methods for making proteins with anti-angiogenic properties are disclosed, including angiostatin, endostatin and restin. The system used is a yeast expression system which produces biologically active proteins at high titer, specifically the Pichia pastores yeast expression system.
Patent IL-137865-A0 (IL)
Title: Method for the diagnosis and follow-up of schizophrenia
IPC: C12Q1/6883
Filed: 2000-08-15
Abstract: A method for the diagnosis of schizophrenia in an individual comprises: (i) measuring mRNA of either D3 dopamine receptor or α7 nicotinic acetylcholine receptor (α7 AChR), and of a control gene in peripheral blood lymphocytes (PBLs) of the individual and of at least one healthy control individual; (ii) calculating the ratio between the receptor mRNA and the control gene mRNA for each individual; and (iii) evaluating the ratio between the ratios obtained in (ii) for the tested individual and for the at least one healthy control individual, wherein (a) an increase in the D3 dopamine receptor mRNA or a decrease in the α7 AChR in the tested individual in comparison to healthy individuals, indicates that said tested individual has a higher likelihood of having schizophrenia than the healthy controls.
Patent IL-138292-A0 (IL)
Title: Medicament for preventing and/or treating a mammary carcinoma, containing a steroidal aromatase inhibitor
IPC: A61K31/5685
Filed: 1999-03-03
Abstract: The use of estrogen formation inhibitor(s) (I) is claimed for the preparation of a topical medicament for the prophylaxis and/or treatment of breast cancer.
Patent IL-139385-A0 (IL)
Title: Labelled glutamine and lysine analogues
IPC: C07B59/00
Filed: 1999-05-14
Abstract: Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.
Patent IL-144685-A0 (IL)
Title: Cut design of diamond for ornamental use
IPC: A44C17/00
Filed: 2001-08-01
Abstract: A cut design for diamonds having a crown of substantially a frustum shape and substantially a conic pavilion directly under the frustum part, the diamond being enhanced in the brilliancy and scintillation of its crown part, the brilliancy and scintillation twinkling, and bluish lights being returned as reflected lights. A crown angle c and a pavilion angle p are so determined that lights coming in crown facets and emitted from crown facets, lights coming in the table facet and emitted from the crown facets, and lights coming in the crown facets and emitted from the table facet be directed toward the observer at the same time. Further, it is preferable to determine the crown angle c and the pavilion angle p so that the angles formed by incident lights and emitted lights are substantially equal to each other. Its table diameter should be between or equal to 0.60 and 0.33, more preferably not more than 0.55 and even more preferably not more than 0.38, in its ratio to the girdle diameter. <IMAGE>
Patent IL-146311-A0 (IL)
Title: Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
IPC: C07D487/04
Filed: 2000-05-05
Abstract: A method for the inhibition of the binding of  alpha 4 beta 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which  alpha 4 beta 1 is involved.
Patent IL-148686-A0 (IL)
Title: Method for producing alkyl-substituted butenols
IPC: C07C33/12
Filed: 2000-09-08
Abstract: Alkyl-substituted butenols having the formula (I): <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-CH<SUB>2</SUB>-CH-CR<SUP>2</SUP>-CH<SUB>2</SUB>OH (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>1 </SUP>is a saturated or olefinically unsaturated alkyl or cycloalkyl group having from 4 to 16 carbon atoms and wherein R<SUP>1 </SUP>is optionally substituted by an alkyl, cycloalkyl, aryl or alkaryl having up to 12 carbon atoms; R<SUP>2 </SUP>is hydrogen or an alkyl group having from 1 to about 6 carbon atoms are produced by a process which comprises: (1) reacting an aldehyde of the formula (II): <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-CH<SUB>2</SUB>-CHO (II)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>1 </SUP>has the same meaning as in formula (I), with the corresponding lower aldehyde to form an unsaturated aldehyde in an inert organic solvent; (2) continuously contacting an optionally calcined copper/zinc catalyst with the unsaturated aldehyde under isothermal conditions at temperatures of from about 45 to about 60° C. and under a hydrogen pressure of from 1 to about 300 bar.
Patent IL-153753-A0 (IL)
Title: Varying-diameter vascular implant and balloon
IPC: A61F2/958
Filed: 2002-12-30
Abstract: A method for deploying an expandable implant in a body passage of varying diameter includes selecting a balloon having a radial dimension that varies, when the balloon is inflated, in accordance with the varying diameter of the body passage. The balloon is inserted, in a deflated state, into the body passage, with the expandable implant fitted radially around the balloon. The balloon is inflated so as to cause the implant to open, responsively to the varying radial dimension of the balloon, into an expanded shape that approximately matches the varying diameter of the body passage, thus anchoring the implant in the body passage.
Patent IL-159082-A0 (IL)
Title: Plastics article with low thermal conductivity, high light transmittance, and absorption in the near infrared region
IPC: B32B27/18
Filed: 2002-07-17
Abstract: A plastic body including a base molded body produced from a transparent, thermoplastic base material, and that includes at least two opposing flat layers interconnected by vertical or diagonal connecting elements. One of the flat layers is provided with an additional layer of a plastic matrix in a transparent, plastic base material. The additional layer is an IR-absorbent layer containing at least one IR-absorber that does not impair transparency of the plastic body and has an average transmission of less than 80% in the region of the near-infrared radiation (780 nm to 1100 nm). The plastic body has a light transmission of between 15% and 86%, a maximum heat transition coefficient of 4 W/m2K and a minimum Sk value of 1.15. The plastic body can be used, e.g., as a glazing element, a roofing element, a heat insulating element.
Patent IL-198741-A0 (IL)
Title: Hepatitis c virus inhibitor compounds, compositions containing the same and uses thereof
Filed: 2009-05-14
Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Patent IL-202088-A0 (IL)
Title: Dms (derma membrane structure) in foam creams
Filed: 2009-11-12
Abstract: The foam formulation comprises an emulsion, which is oil in water emulsion and basically an emulsifying agent-free emulsion, i.e. the emulsion has an oil phase and a water phase. The oil phase has a membrane-forming substance, which is insoluble in water and forms a lamellar membrane in the foam formulation. The membrane-forming substance is a lipid, preferably 8-12 carbon triglyceride, and the lipid is a phospholipid, preferably lecithin, and a liquid wax ester. A thickening agent, a stabilizer, which has pentylene glycol, usual components and active ingredients are also provided. An independent claim is also included for a method for producing a foam formulation, which involves manufacturing an emulsion, preferably oil in water type, filling the emulsion and a foaming agent into a pressure-vessel or filling the emulsion into another pressure-vessel, which produces a foam by delivery of the emulsion. ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.
Patent RO-132348-A0 (RO)
Title: Multifunction kerb
Inventor: SAS ADRIAN CRISTIAN
IPC: E03F5/042
Filed: 2016-08-02
Abstract: The invention relates to a multifunction kerb which may simultaneously have a plurality of functions beside the function of separating the passable road from the pedestrian zones or the green zones: it may take over the water from the passable road and may convey inside cables and pipes in safety conditions. According to the invention, the kerb consists of a parallelepipedal body (1) on top of which there is a pyramid with a cross-section in the shape of a parallelogram with the large base downwards, provided with a main internal channel (2), an internal channel (3) for optic fibres, an internal channel (4) for the electric cable which supplies with electric power the traffic lights and public lighting, an internal channel (5) for the electric cables and four internal cylindrical thermal channels (9) wherethrough the electric resistors that ensure the winter-time kerb heating pass, three identical cylindrical drain ditches (6) which pass slantingly through the kerb and cross the main channel (2), a reflective zone (7) in the shape of a bow arranged all along the kerb, two rectangular cutouts (8) placed at the ends of the kerb, on the face toward the passable road, intended for handling the kerb, one cutout (10) for a chip reader and the meter and one cutout (11) for the current takeoff, the channels (2, 3, 4 and 5) being provided, at both ends of the kerb, with a concentric channel (12) of semicircular cross-section in which rubber gaskets are introduced for sealing purpose.
Patent MC-2284-A1 (MC)
Inventor: MONSIEUR ALAIN BOUCHERON
IPC: G04B45/00
Filed: 1991-07-25
Abstract: Wrist-watch comprising a case (1) enclosing the clockwork mechanism and provided with a dial (10), a flexible strap (2) provided with rigid reinforcement elements (3) at the ends interacting with two opposite sides (5a, 5b) of the case, and a removable cover (4) mounted by means of nesting over the case (1), the cover being provided with a window (15) for the dial of the case and elastic locking members (16a, 16b) interacting with the case and the reinforcement elements (3) of the flexible strap (2) for mounting the cover on the case. 
<IMAGE>