baber/WOPTO huggingface dataset:
Patent HU-T73461-A (HU)
Title: Anti-egfr single-chain fvs, anti-egfr antibodies
Inventor: ADAN JAIME
IPC: C07K16/28
Filed: 1995-03-16
Abstract: PCT No. PCT/EP95/00978 Sec. 371 Date Nov. 17, 1995 Sec. 102(e) Date Nov. 17, 1995 PCT Filed Mar. 16, 1995 PCT Pub. No. WO95/25167 PCT Pub. Date Sep. 21, 1995This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse. Two of the single-chain Fvs isolated from the phage-antibody libraries were engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-chain Fvs as agents for the diagnosis and therapy of human tumors.
Patent IL-42250-A (IL)
Title: 6alpha-methylprednisolone-21-metasulphobenzoate preparation process and pharmaceutical compositions
IPC: C07J5/00
Filed: 1973-05-11
Abstract: 1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6α-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the corresponding 21-methanesulphonate by reaction with a di-(alkali metal) m-sulphobenzoate in the presence of an N-alkyl-amide (e.g. DMF), and may be converted to the free acid by passing over an acidic ion-exchange resin. The free acid may thereafter be resalified. 6α-Methylprednisolone 21-methanesulphonate is prepared from the free 21-ol by reaction with mesyl chloride. Antiinflammatory compositions for oral, parenteral, topical and rectal administration comprise a compound of the invention and a carrier.
[GB1375357A]
Patent IL-42343-A (IL)
Title: N-substituted-n'-((benzoxazole-7-carboxamidoalkyl)benzene-sulfonyl)ureas and process for their manufacture
IPC: C07D263/56
Filed: 1973-05-24
Abstract: 1429841 Benzenesulphonyl-ureas HOECHST AG 25 May 1973 [26 May 1972] 25128/73 Heading C2C Novel compounds (I) (including salts thereof) in which R 1 represents a hydrogen atom or an alkyl or aryl radical; X represents a hydrogen or a halogen atom or an alkyl radical; Y represents an alkyl radical which may be straight-chain or branched, separating the nitrogen from the aromatic ring by 2 carbon atoms, and R represents an alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl, cycloalkenylalkyl, halocycloalkyl, bicycloalkenylalkyl, bicycloalkylalkyl, bicycloalkenyl, bicycloalkyl, nortricyclyl, adamantyl or phenylalkyl radical, are made by standard methods. Pharmaceutical preparations showing hypoglycemic action contain (I) as active ingredient; administration may be orally or parenterally.
[GB1429841A]
Patent IL-79378-A (IL)
Title: Mixing apparatus
IPC: B01F7/24
Filed: 1986-07-09
Abstract: Apparatus for mixing liquid and liquid suspension mediums in vessels with a mixing impeller shaft system of a composite of fibrous and plastic material of a structural configuration to enable the use of such material in commercial and industrial applications where the reaction loads of the medium on the system militate against the use of composite fibrous and plastic material. The system utilizes impellers having blades which distribute the reaction load through a hub on a mounting area of a shaft with keys and keyways in a manner to avoid stress risers unamicable to the composite material and which can cause failure thereof. Separate keys and keyways are provided to oppose the thrust due to the reaction loads and to oppose the torque due to such loads. Plural thrust keyways may be used to enable the impeller to be located at different positions on the shaft and at selected heights above the floor of the mixing vessel. Proplets on the tips of the blades extend entirely in the direction of the low pressure surface of the blades to control the flow field in the vessel and provide a more axial velocity profile of the inlet flow to the impeller which is nearly axial and substantially reduces the strength of the tip vortices.
Patent IL-85445-A (IL)
Title: Ester-substituted diaminedithiols and radiolabeled complexes thereof
IPC: A61K/
Filed: 1988-02-17
Abstract: Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula -A-COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide. CROSS-REFERENCE TO RELATED APPLICATIONS   This application is a continuation-in-part of copending application Serial No. 016,982, filed February 18, 1987.
Patent IL-92269-A (IL)
Title: Pharmaceutical compositions comprising nalmefene or naltrexone for treatment of autoimmune diseases
IPC: C07D489/08
Filed: 1989-11-10
Abstract: A method of treating a human or animal patient suffering from an autoimmune disease comprises daily administration to such patient of from about 1 to about 100 mg of the narcotic antagonists nalmefene or naltrexone. The nalmefene (6-methylene-6-desoxy-N-cyclopropyl-methyl-14--hydroxydihydronormorphine) or naltrexone (N-cyclopropylmethyl--14-hydroxy-dihydromorphinone) may be administered in equally divided doses from one to four times daily, preferably by the oral route. Parenteral administration may be utilized where suitable.
Patent IL-93828-A (IL)
Title: Substrate for non-soil cultivation
IPC: A01G1/00
Filed: 1990-03-21
Abstract: The invention relates to a substrate for soil-less culture, composed of inorganic fibres. 
<??>The substrate according to the invention has limited dimensions and is used for the culture phase which corresponds to the development of the young plants. This substrate has the general shape of a parallelepiped and is provided on its bottom face with projections having a small surface area, which isolate the substrate from the ground on which it rests. 
<??>The substrate according to the invention allows the culture conditions to be improved. 
<IMAGE>
Patent IL-94154-A (IL)
Title: Components and catalysts for the polymerization of olefins
IPC: C08F10/00
Filed: 1990-04-20
Abstract: Described is a process for the polymerization of olefins carried out in the presence of a catalyst comprising the product of the reaction of an Al-trialkyl compound and a catalyst component comprising a titanium compound containing at least one Ti-halogen link supported on anhydrous magnesium chloride, said component being in the form of spherical particles with an average diameter between 10 and 350  mu m, surface area between 20 and 250 m<2>/g, porosity greater than 0.2 cc/g, having an X-ray spectrum where a) reflections at angle 2 theta of 35 DEG  and 2 theta  of 14.95 DEG  are present, or b) where the reflection at 2 theta  angle of 35 DEG  is no longer present but is substituted by a halo with a maximum intensity between angles 2  theta  of 33.5 DEG  and 35 DEG , and the reflection at angle 2 theta  of 14.95 DEG  is not present.
Patent IL-95342-A (IL)
Title: Sequence of anti-direction, anti-messenger rna oligonucleotides of alpha tnf, preparation process, use as medicaments and pharmaceutical compositions
IPC: A61K31/70
Filed: 1990-08-10
Abstract: The application relates to an anti-sense oligonucleotide sequence which is an anti-RNA against TNF alpha messenger RNA, of formula (I): TCA TGG TGT CCT TTG CAG-X (I> in which X represents hydrogen or a sequence of 1 to 17 oligonucleotides in free, alkylated or sulphur-containing form or in the form of poly-L-lysine derivatives, process for the preparation thereof, medical use thereof and pharmaceutical preparations containing this novel sequence.
Patent IL-96049-A (IL)
Title: Preparation of pure, unsymmetrically disubstituted ureas
IPC: C07D263/58
Filed: 1990-10-17
Abstract: Process for the preparation of pure, unsymmetrically disubstituted ureas of the general formula   <IMAGE> I  in which R denotes a phenyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy, aryloxy or trifluoromethyl groups, an oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, benzoxazolyl or benzothiazolyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy or trifluoromethyl groups and R1 and R2 independently of one another denote a hydrogen atom or an alkyl group, where R1 and R2 are not simultaneously hydrogen or R1 and R2 together denote a butylene or pentylene group, by reaction of an N-alkyl- or N,N-dialkylurea with an unsubstituted or substituted arylamine or a heterocyclic amine in the presence of that amine which is already present in the starting material, the respective N-alkyl- or N,N-dialkylurea.
Patent JP-H02192802-A (JP)
Title: Production of metallic sheet for shadow mask
Inventor: OSAKI KEIJI
IPC: B21B27/00
Filed: 1989-01-20
Abstract: PURPOSE:To allow the vacuum adhesion of a reference pattern made of glass and to improve the quality of perforation by etching by executing rolling several times by using dull rolls subjected to fine ruggedness working and increasing the area occupying rate of the rugged surface on the front surface without increasing average roughness. CONSTITUTION:The surface of one roll or both rolls of work rolls for rolling are subjected to fine ruggedness working. The metallic sheet is rolled 3 to 5 times by using such dull rolls to form the surfaces consisting of the ruggedness having 0.2 to 1.mum Ra center line average height of the surface on the front surfaces of one or both surfaces of the sheet in such a manner that the area occupying rate of the surfaces satisfy >=80%. The air flow passages at the time of evacuation to a vacuum are sufficiently and uniformly assured and the adhesive property of the reference patterns made of glass is improved. The etching property of the metallic sheet for shadow masks is, therefore, improved.
Patent JP-S62179202-A (JP)
Inventor: JIEIMUZU OO ERIOTSUTO
IPC: H01Q5/15
Filed: 1987-01-21
Abstract: (57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。
Patent JP-H04245184-A (JP)
Title: Connector lineup modification device
Inventor: IWASAKI MASAYUKI
IPC: H01R43/00
Filed: 1991-01-31
Abstract: PURPOSE:To prevent the breakdown during the setting of a connector by providing a comb-shaped groove for modification for inserting the terminal element of a connector plug and a spring for giving vertical energizing force to the device body. CONSTITUTION:A terminal modifying device body 1 is set on the side of setting of a connector plug 8, and a terminal element 8a is inserted in a groove 2 for terminal modification. Next, by rotating a handle 7, the body 1 operates in the direction of an arrow A. Springs 6 for control are attached for operation control to both sides of the body 1. By the operation in the direction of arrow A of the body 1, the unequal pitches of the terminal elements inserted in the grooves 2 for terminal modification are modified. If one repeats the rotational operation of the handle 7 plural times, it comes that the operation in both directions of the arrow A are repeated, conjointly with the energizing force of the spring 6, so the spring back action of the terminal element decreases, and finally those are modified into the terminal elements of equal pitches.
Patent JP-H02190097-A (JP)
Title: On-vehicle speaker device
Inventor: DATE TOSHIHIKO
IPC: B60R11/02
Filed: 1989-01-18
Abstract: PURPOSE:To improve the matching of an acoustic impedance by providing an acoustic tube leading sound from a speaker installed in a trunk room to a space in a cabin and expanding gradually the width of the acoustic tube from a seat side toward a rear window. CONSTITUTION:A couple of left and right speakers 2 are installed toward the seat of a trunk room 1 provided to the rear part of a vehicle, and acoustic tube 6 leading the acoustic output from each speaker 2 to the in-cabin space 5 is provided to a rear tray section 4 partitioning the cabin 3 and the trunk room 1. One opening 6a of each acoustic tube 6 connects to the speaker 2 and other opening 6b of each acoustic tube 6 connects to the speakers 2 and each other opening 6b being a communicating opening with the in-cabin space 4 is opposed to the rear window 7. Moreover, each acoustic tube 6 is gradually spread toward the side opening 6b along a lower face of a flat plate 4a being a component of the rear tray 4. Thus, the matching of the acoustic impedance is improved.
Patent JP-H11215803-A (JP)
Title: Current-type self-exciting converter device
Inventor: YOSHINO TERUO
IPC: H02M7/12
Filed: 1998-01-22
Abstract: PROBLEM TO BE SOLVED: To stop-control a converter in safety and thereby enable the protection of the converter at the time of an accident, by using only on-gate signals for turning on a self arc-extinguishing element comprising the converter for the protective operation. SOLUTION: When a current passing through a converter 1 starts to increase, an accident is detected. At this time, a control pulse switching means 103 brings the ordinary output of a PWM control circuit 16 into disuse, causes a protective pulse generating means 102 to output only on-gate pulses not in PWM pulse waveform, and prevents the protective pulse generating means 102 from outputting off-gate pulses, for example. Protective pulses comprising only the on-gate pulses are taken as an inverter operation region (angle of delay: 90 deg. or above) for alternating-current voltage phase, and sequentially supplied to a semiconductor valve 30 comprising a bridge. A commutation phenomenon is caused due to the impedance of a transformer 4 for the converter and a current circulating in the semiconductor valve 30.  Thus excitation is repeated in order without current interruption of a self arc-extinguishing element due to off-gate pulses, and direct-current energy can be converted into alternating- current energy.
Patent JP-S59136952-A (JP)
Title: Material for semiconductor substrate
Inventor: OSADA MITSUO
IPC: H01L23/14
Filed: 1983-01-25
Abstract: PURPOSE:To obtain a material, which satisfies both thermal conductivity and a thermal expansion coefficient and to which there is no problem, such as virulence, difficulty for acquistition, etc., by mixing and molding Cu powder at a specific rate and W powder, Mo powder or W-Mo alloy powder in specific grain size and baking the shape in a reducing atmosphere. CONSTITUTION:Cu Powder at a final product ratio of 5-20wt% and W powder, Mo powder or W-Mo alloy powder in 0.5-5mum mean grain size are mixed and molded, and baked in a reducing atmosphere. A Cu ratio is brought to 5- 20wt% in order to keep a thermal expansion coefficient within a range of 6-8 (X10<-6>/ deg.C). The mean grain size of W powder or Mo powder is brought to 0.5- 5mum because the bulk of powder is large and density on molding is difficult to increase owing to the air being contained among powder at pressing and molding at 0.5mum or less and the powder must be sintered at 1,500 deg.C or more in order to obtain a dense alloy with Cu, Cu disappears remarkably due to evaporation, the variability and variation of compositions are generated and an alloy of predetermined compositions is difficult to be acquired at 5mum or more.
Patent JP-S55102359-A (JP)
Title: Automatic squeezer for inner ingredient such as cream
Inventor: MASUDA FUMIHIKO
IPC: A23G3/28
Filed: 1979-01-31
Abstract: PURPOSE: The vertical motion of the gate fitted on the squeezer for the vessel containing the inner ingredient such as cream is interlocked with the cam mechanism with two plates of cam, thus permitting the readily control of the squeeze length of the inner ingredient even during operation.  
     CONSTITUTION: Frame 1 that can run freely with wheels 2 is provided with vertical support 5, to which vessel 6 containing the inner ingredient such as cream is fitted. Squeezer 7 having openable gate 8 is mounted on the lower side so that the vertical motion of gate 8 controls the opening of squeezer 7. The upper part of gate 8 is connected through horizontal arm 9 to vertical arm 10 that can make freely vertical motion. The arm 10 is connected to the one end of connecting rod 11, e.g., crank, and roller 12 is fitted on the other end of rod 11. The roller is related to cam mechanism 13 with 2 cam plates 14, 15, which slides on each other and the mechanism 13 drives to make arm 10 through rod 11 vertical motion and further arm 9 and gate 8 vertical motion, thus closing or opening the squeezer 7. 
     COPYRIGHT: (C)1980,JPO&Japio
Patent JP-H08262728-A (JP)
Title: Photosensitive resin composition and pattern forming method using same
Inventor: TSUSHIMA HIROSHI
IPC: G03F7/075
Filed: 1996-01-25
Abstract: PURPOSE: To shorten exposure time and to enhance the productivity of a color filter, etc., by incorporating polysilane having a specified wt. average mol.wt. and soluble in an org. solvent, an optical radical generating agent, an oxidizing agent, specified silicone oil and an org. solvent. CONSTITUTION: This resin compsn. contains polysilane having a wt. average mol.wt. of >=10,000 and soluble in an org. solvent, an optical radical generating agent, an oxidizing agent, silicone oil represented by the formula and an org. solvent. In the formula, each of R<1> -R<6> is 1-10C optionally halogen or glycidyl substituted aliphatic hydrocarbon, 6-12C optionally halogen substituted aromatic hydrocarbon or 1-8C alkoxy, each of (m) and (n) is an integer and m+n>=1. Network polysilane is preferably used as the polysilane in consideration of mechanical strength as a photosensitive material.
Patent JP-S63177955-A (JP)
Title: Method for producing titanium alloy cast block
Inventor: YAMANAKA AKIHIRO
IPC: B22D23/00
Filed: 1987-01-20
Abstract: PURPOSE:To execute addition of a little quantity of a component under high yield by using green compact blending additional element to sponge titanium or powdered titanium as core material, melting by heating cylindrical body winding a thin sheet of main element on the outside from one end, and solidifying by dropping the drips into the mold. CONSTITUTION:The green compact 1 blending a little quantity of the additional element to the sponge titanium, etc., is made to the core material, and melting raw material 4 is made by winding alternately Ti-made thin sheet 2 and Nb- made thin sheet 3 on this core material. The melting raw material 4 arranged in a vacuum room 5 of electron beam furnace is irradiated by electron beam through an electron gun 6 from the lower part thereof while rotating and descending the raw material. In this way, Ti, etc., in the material 4 is melted without any loss, and is made to the drip and solidified in the metal pool 8 in the water cooled copper mold 7, to draw from the mold 7 as the Nb-Ti series alloy cast block 9. Thus, the material having high melting point is not remained to melt and Nb-Ti series alloy casting block for super conductivity material having uniform composition is stably produced at comparatively few number of process.
Patent JP-H07220546-A (JP)
Title: Grommet
Inventor: TAKAHASHI TAKESHI
IPC: H02G3/22
Filed: 1994-02-02
Abstract: PURPOSE:To provide a grommet which can be installed easily in an installation panel and which can be manufactured easily at low cost. CONSTITUTION:A plurality of circular grooves 7 are formed circularly in a part of a tapered outer circumferencial face 5 of a grommet main body 1 wherein the part touches the periphery of an installation hole. That is, circular pleats 6 formed concentrically by the circular grooves 7 are formed into layers while keeping a gap between pleats 6. When the grommet main body 1 is installed in an installation hole H, being brought into contact with a burring part C of the installation hole H, the outer circumferential face 5 of the grommet main body 1 slides in the extended direction. At that time, since the circular pleats 6 formed on the outer circumferential face 5 fall down in the reverse direction to the extended direction, the friction resistance between the burring part C of the installation hole H and the outer circumferential face 5 of the grommet main body 1 is lessened and the grommet main body 1 can be installed in the installation hole H with low setting force.
Patent JP-S61171703-A (JP)
Title: Production of hyaluronic acid
Inventor: TAKAHASHI TAKESHI
IPC: C08B37/08
Filed: 1985-01-24
Abstract: PURPOSE:To produce high-purity hyaluronic acid useful as a bulk of drug or cosmetic by a simple operation in an industrial scale efficiently, by treating a hyaluronic acid-containing bond tissue with protease in the presence of a reducing agent and fractionating the treated material. CONSTITUTION:A hyaluronic acid-containing bond tissue (e.g., comb. vitreous body of eye, cartilage, etc.) of animal as a raw material is usually immersed in a sufficient amount of water, heated at 70-100 deg.C for 1hr, treated with protease (0.1-1g papain is used based on 100g raw material) in the presence of a reducing agent (preferably 0.5-1.5g based on 100g raw material) such as sodium thiosulfate, hydrosulfite, etc., and usually 2-4g based on 100g raw material of cetyl pyridinium bromide is added to the treated material to carry out fractionation. Before the fractionation treatment is done, a crude hyaluronic acid-containing solution is blended with NaCl in an amount to make final concentration 0.3-1M and preferably stirred for 20-40min.
Patent JP-S58128346-A (JP)
Title: Phenylnitropropyl acetate derivative, its preparation and agricultural and horticultural germicide containing the same as active constituent
Inventor: FURUSAWA KUNIHIKO
IPC: C07C253/00
Filed: 1982-01-26
Abstract: NEW MATERIAL:A compound of formulaI(X and Y are H, lower alkyl, halogen, CF3, NO2 or CN). EXAMPLE:1-(4-Chlorophenyl)-3-methyl-3-nitropropyl acetate. USE:An agricultural and horticultural germicide, having particularly improved germicidal effect on pathogenic germs of plants belonging to the class Fungi Imperfecti, and further on Piricularia oryzae, Fusarium oxysporum, Ascochyta pisi, etc. PROCESS:Acetic acid or a reactive derivative thereof is reacted with a phenylnitropropyl alcohol derivative of formula II in the presence or absence of a solvent, if necessary a reaction assistant, e.g. phosphorus pentachloride in the case of acetic acid and a base in the case of acetyl chloride, to give the compound of formulaI.
Patent JP-H11213098-A (JP)
Title: Shutter device for sheet material carrying route
Inventor: KOJIMA SUSUMU
IPC: G06K13/06
Filed: 1998-01-23
Abstract: PROBLEM TO BE SOLVED: To provide a compact shutter device capable of preventing the insertion of a foreign substance into a sheet material carrying route as much as possible, furthermore improving the opening/closing speed of the carrying route and reducing the number of parts. SOLUTION: The shutter device is provided with a 1st arm 5 having an approximately L shape and its rear end part 5c pivoted rotatably on a shaft 4 5c on one side of a sheet material carrying route in a card carrying route 3, a 2nd arm 7 having an approximately L shape and its rear end part 7c pivoted rotatably on a shaft 6 on the other side and a connection means 8 for connecting the tip 5d of the 1st arm 5 to the tip 7d of the 2nd arm 7, and at the time of rotating either one of the arms 5, 7 to one direction around the shaft, rotating the other arm to the reverse direction around the shaft. The device is also provided with a rotation means 11.  When the 2nd arm 7 is rotated in one direction around the shaft 6 by the means 11, the whole width direction area of the sheet material carrying route is blocked by the 1st and 2nd arms 5, 7, and when the arm 7 is rotated to the reverse direction around the shaft 6, the whole width direction area of the sheet material carrying route is opened by the 1st and the second arms.