Patent SG-11201805459U-A (SG)
Title: Isotope preparation method
Inventor: MANTZILAS DIMITRIOS
IPC: A61K51/06
Filed: 2016-12-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111011111111110111111011111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number ..... ....!;,„./ (43) International Publication Date WO 2017/118591 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: BIP PATENTS; c/o Bayer Intellectual Property BOlD 15/18 (2006.01) B01J 41/05 (2017.01) GmbH, Alfred-Nobel-Str. 10, 40789 Monheim am Rhein A61K 51/06 (2006.01) A61K 51/12 (2006.01) (DE). BOlD 15/36 (2006.01) G21G 1/00 (2006.01) BO1J 39/05 (2017.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/EP2016/082835 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 29 December 2016 (29.12.2016) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 1600154.7 5 January 2016 (05.01.2016) GB ZA, ZM, ZW. (71) Applicant: BAYER AS [NO/NO]; Drammensveien 288, (84) Designated States (unless otherwise indicated, for every 0283 Oslo (NO). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: MANTZILAS, Dimitrios; Hans Hammerens TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Veg 18, 1920 Sorumsand (NO). KARLSON, Jan Roger; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Normanngata 42, 0655 Oslo (NO). OSTBY, Judit Tjelme- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = land; Lokenveien 5, 1408 Krakstad (NO). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = — GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] — = Title: ISOTOPE PREPARATION METHOD (54) a....11..6 ro .,„„„„..„, (57) : The present invention comprises a method for the generation — _ of 227 Th of pharmaceutically tolerable purity comprising i) preparing a gen- erator mixture comprising 227 Ac, 227 Th and 223 Ra; ii) loading said generator = _ \"VZ.' . ;!`.77 m ' fV r' ' ,, ,a' '-- . v....... mixture onto a strong base anion exchange resin; iii) eluting a mixture of ...Mar dr,las = 223 227 said Ra and Ac from said strong base anion exchange resin using a = b4.. 1bmao122,4 iu 1.3 ARM ___>, first mineral acid in an aqueous solution; iv) eluting Th from said strong 227 base anion exchange resin using a second mineral acid in an aqueous solu- = y = , ..altfl,, ,-, Z:>\";1;.7ZZ. tion whereby to generate a first 227 Th solution containing contaminant 2 \" Ra — 1 3 Ad HC1 j (ani.x. wimp teibl) and 227 Ac; v) loading the first 227 Th solution onto a strong acid cation ex- -- + If (4b) 1 change resin; vi) eluting at least a part of the contaminant 223 Ra and 227 Ac = iv I u3 EIGI i al. [ BM. = »<U..n., from said strong acid cation exchange resin using a third mineral acid in = aqueous solution; and vii) eluting the 227 Th from said strong acid cation ex- change resin using a first aqueous buffer solution to provide a second Th 227 /SARIN°. I r , '\"11 .21.‘lcadoc *I a~vmcbeaua ramp = L 1 10 Nti....'0 ^Shd HO, „tie — solution. Purified thorium-227 of pharmaceutical purity and a pharmaceutic - ay.. : NII.A.30, al composition comprising the same are also provided. * Id M NNO, I -4 Ac0.15mEpa cv..nt el..te — Nfr = I i MEM. ,.. .11, nc '2111ead t2 — I --> 31.0 ''''''''wh'W '='\" Il Ifthtla,AeliOng I 311i; '\" I Napansbw of .Tb e:ux.. 11 CiN f....arm.vd) ir) ; 10, Q,-,.. phDs zleese ....8,t Ittnri.an.2rebiertde GC eyedauibw Il Il ......., Figure 1 - Manufacturing process and process control IN 11 © N O WO 2017/118591 Al 1#11101MOMMIONOMOMOIEMEHMOIMMOIMIE Declarations under Rule 4.17: Published: — as to applicant's entitlement a patent (Rule 4.1700) to apply for and be granted — with international search report (Art. 21(3))