Patent SG-11201808138Y-A (SG)
Title: Substituted indole derivatives as dengue viral replication inhibitors
Inventor: BARDIOT DOROTHÉE ALICE MARIE-EVE
IPC: A61K31/4045
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111011110110101011111010111110110111100111111110011111111111111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/167950 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 209/14 (2006.01) A61P 31/14 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/4045 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/057660 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 31 March 2017 (31.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 16163312.8 31 March 2016 (31.03.2016) EP (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: JANSSEN PHARMACEUTICALS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, New Jersey 08560 (US). KATHOLIEKE UNI- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 3000 Leuven (BE). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: BARDIOT, Dorothee Alice Marie-Eve; c/o SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, — Cistim Leuven vzw Gaston Geenslaan 2, 3001 Leuven GW, KM, ML, MR, NE, SN, TD, TG). — (Heverlee) (BE). BONFANTI, Jean-Francois; c/o Declarations under Rule 4.17: _ Janssen-Cilag 1 rue Camille Desmoulins, TSA 91003, — as to applicant's entitlement to apply for and be granted a 92787 Issy-les-Moulineaux Cedex 9 (FR). KESTELEYN, 4.1700) = Bart Rudolf Romanie; Pharmaceutica NV patent (Rule c/o Janssen Turnhoutseweg 30, 2340 Beerse MARCHAND, Published: (BE). = Arnaud Didier M; c/o Cistim Leuven vzw Gaston Geens- = - with international search report (Art. 21(3)) = laan 2, 3001 Leuven (Heverlee) (BE). RABOISSON, Pierre Jean-Marie Bernard; c/o Janssen Pharmaceutica — with sequence listing part of description (Rule 5.2(a)) NV Turnhoutseweg 30, 2340 Beerse (BE). (74) Agent: VERBERCKMOES, Filip; J&J Patent Law De- = partment Turnhoutseweg 30, 2340 Beerse (BE). = = = = = = = = 1-1 © kr) 0\ IN 1-1 (54) Title: SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS 1-1 C (57) : The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by N using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or 0 prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara- tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.