Patent SG-11201909252X-A (SG)
Title: Fgfr3 binding molecules
Inventor: SILACCI MELKKO MICHAELA
IPC: C07K14/705
Filed: 2018-04-03
Abstract: 1 O O GC 1-1 00 O 1-1 N O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit VIII °nolo OH H 100 0111010110111110 oimIE (10) International Publication Number WO 2018/185050 Al (51) International Patent Classification: CO7K 16/28 (2006.01) CO7K 14/705 (2006.01) (21) International Application Number: PCT/EP2018/058390 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17164482.6 03 April 2017 (03.04.2017) EP (71) Applicant: COVAGEN AG [CH/CH]; Gubelstrasse 34, 6300 Zug (CH). (72) Inventors: SILACCI MELKKO, Michaela; Archimedesweg 4-6, 2333 CN Leiden (NL). WOODS, Richard; Archimedesweg 4-6, 2333 CN Leiden (NL). HENNE, Patricia; Archimedesweg 4-6, 2333 CN Leiden (NL). ZUBLER, Barbara; Archimedesweg 4-6, 2333 CN Leiden (NL). KAGE, Elena; Archimedesweg 4-6, 2333 CN Leiden (NL). GRABULOVSKI, Dragan; Archimedesweg 4-6, 2333 CN Leiden (NL). BERTSCHINGER, Julian; Archimedesweg 4-6, 2333 CN Leiden (NL). (74) Agent: VERHAGE, Richard, A et al.; Archimedesweg 4-6, 2333 CN Leiden (NL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: FGFR3 BINDING MOLECULES (57) : The present invention relates to a polypeptide binding to fibroblast growth factor receptor 3 iso forms 3b and 3c (FGFR3b and FGFR3c), wherein the polypeptide comprises an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDYEVYGPTPMLSFHKGEKFQIUX 1)(X2X3) (X 4 )GPYWEARSL(X)TGETG(X)IPSNYVAPVDSIQ (SEQ ID 5 6 NO: 1), wherein amino acid positions (X) to (X) may be any amino acid sequence; (b) an amino acid sequence which is at least 95% 1 6 identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X 1 ) to (X) and provided 6 that the amino acid sequence EVYGPTPM (SEQ ID NO: 2) in amino acid positions 12 to 19 of SEQ ID NO: 1 is conserved and the amino acids P and Yin amino acid positions 37 and 38 of SEQ ID NO: 1 are conserved; (c) GVTLFVALYDYEVMSTTALSFHKGEKF QILSQSPHGQYWEARSLTTGETG(X 6 )IPSNYVAPVDSIQ (SEQ ID NO: 19), wherein the amino acid position (X 6 ) may be any amino acid; and (d) an amino acid sequence which is at least 95% identical to the amino acid sequence of (c), wherein the identity determination excludes amino acid position (X 6 ) and provided that the amino acid sequences EVMSTTA (SEQ ID NO: 20) in amino acid positions 12 to 18 of SEQ ID NO: 19 and SQSPH (SEQ ID NO: 21) in amino acid positions 31 to 35 of SEQ ID NO: 19 are conserved and the amino acids Q and Y in amino acid positions 37 and 38 of SEQ ID NO: 19 are conserved.