baber/WOPTO huggingface dataset:
Patent NZ-581474-A (NZ)
Title: Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
Inventor: BAILEY JAMES E
IPC: C12N5/06
Filed: 2002-08-05
Abstract: Provided is a glycoengineered antibody that specifically binds the human CD20 antigen, wherein the glycoengineered antibody has an increased proportion of bisected complex oligosaccharides having the m/z values of 1689, 1705, 1851, and 1867 Daltons, a decreased proportion of non-bisected complex oligosaccharides having the m/z value of 1648 Daltons, and wherein the glycoengineered antibody reaches the maximal ADCC activity of the corresponding non-glycoengineered anti-CD20 antibody at an antibody concentration that is approximately five to ten-fold lower as a result of the glycoengineering.
Patent NZ-591793-A (NZ)
Title: Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds
Inventor: NISHIDA HARUYUKI
IPC: A61K31/444
Filed: 2009-08-26
Abstract: Disclosed are substituted compounds of 4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (Formula I), salts thereof and methods for their preparation. Specific examples of compounds of Formula I include: 1-{ 4-Fluoro-5-(2-fluoropyridin-3-yl)-1-[(4-methylpyridin-2-yl)sulfonyl]-1H-pyrrol-3-yl} -N-methylmethanamine, and 1-{ 4-Fluoro-5-(2-fluoropyridin-3-yl)-1-[(4-methoxypyridin-2-yl)sulfonyl]-1H-pyrrol-3-yl} -N-methylmethanamine. The pyrrolyl compounds have an acid secretion suppressive activity and are potassium-competitive acid blockers. The compounds are useful for treating peptic ulcer, Zollinger-Ellison syndrome, gastritis, reflux esophagitis, symptomatic gastroesophageal reflux disease, Barrett's oesophagus, functional dyspepsia, gastric cancer, stomach MALT lymphoma, or ulcer caused by non-steroidal anti-inflammatory drug, gastric hyperacidity or ulcer due to postoperative stress; or an inhibitor of upper gastrointestinal bleeding due to peptic ulcer, acute stress ulcer, hemorrhagic gastritis or invasive stress
Patent NZ-593808-A (NZ)
Title: Inhibitors of hcv ns5a
Inventor: LI LEPING
IPC: A61K31/422
Filed: 2009-12-02
Abstract: 593808 The disclosure relates to substituted heterocyclic compounds containing five-membered rings either condensed or non-condensed and containing further heterocyclic rings useful for inhibiting hepatitis C virus (”HCV”) replication, particularly functions of the non-structural 5A (”NS5A”) protein of HCV.
Patent NZ-595526-A (NZ)
Title: Pharmaceutical composition comprising a vla-4 binding antibody, a phosphate buffer and a surfactant
Inventor: MALONEY KEVIN
IPC: A61K39/395
Filed: 2008-06-13
Abstract: 595526 Disclosed is the use of an aqueous pharmaceutical composition comprising a VLA-4 binding antibody at a concentration of about 120 mg/ml to about 190 mg/ml, a sodium phosphate buffer at a concentration of about 5 mM to about 15 mM, sodium chloride at a concentration of about 130 mM to about 150 m 5 M and polysorbate at an amount of about 0.02% to about 0.08% (w/v), wherein the pH of the composition is pH 6+-0.5 in the manufacture of a medicament for the treatment of an inflammatory, immune, or autoimmune disorder.
Patent NZ-595792-A (NZ)
Title: Antibodies specific to cadherin-17
Inventor: ROHLFF CHRISTIAN
IPC: G01N33/574
Filed: 2010-04-20
Abstract: NZ 595792 Disclosed is an isolated anti-Cadherin-17 antibody comprising a heavy chain variable region amino acid sequence set forth in SEQ ID NO: 38 as defined in the complete specification or an amino acid sequence having at least 80% sequence identity thereto, and a light chain variable region amino acid sequence set forth in SEQ ID NO: 49 as defined in the complete specification or an amino acid sequence having at least 80% sequence identity thereto. The disclosed antibody is used in the treatment of cancer.
Patent NZ-597483-A (NZ)
Title: N1-substituted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
Inventor: BOEBEL TIMOTHY
IPC: A01N47/38
Filed: 2010-08-05
Abstract: The present disclosure relates to the field of N1-substituted-5-fluoro-2-oxopyrimidinone-1-(2H)-carboxamides of formula (I) and their derivatives and to the use of these compounds as fungicides, wherein the variables are as defined in the specification.
Patent NZ-600455-A (NZ)
Title: Retractable clinical syringe with a replaceable needle assembly
Inventor: THORLEY CRAIG STEPHEN
IPC: A61M5/315
Filed: 2010-11-11
Abstract: 600455 A replaceable needle assembly is provided for a retractable syringe (10) comprising a barrel (11) and a plunger (20), whereby the retractable needle (30) can be replaced by a user without affecting the retraction mechanism. A mounting member (40) is removably mountable to the barrel (11) by way of a screw-thread connection and a needle mount is removably coupled to the mounting member (40). A needle (30) is mounted to the needle mount (34). The barrel (11) comprises a needle mount retainer (60) that comprises a plurality of fingers that engage the retractable needle mount (34) to prevent inadvertent retraction. The plunger (20) comprises a collapsible seal (80) which maximizes the efficiency of fluid delivery prior to the plunger (20) engaging the retractable needle mount (34) for retraction. An initially compressed spring decompresses to drive retraction of the plunger (20) and the engaged needle mount (34). A lock formed between the plunger (20) and barrel (11) prevents further use of the plunger after retraction.
Patent NZ-601287-A (NZ)
Title: Fluid transfer assembly and methods of fluid transfer
Inventor: SPRINGER JOSHUA
IPC: B65B3/04
Filed: 2011-01-19
Abstract: 601287 Disclosed is a fluid dispensing assembly (100). The assembly has a valve for dispensing a fluid to a fluid container (102) coupled to the valve at a bottom (104) of the fluid container. The valve has a first sensor detecting proper placement of the fluid container based on a magnetic material positioned at the bottom of the fluid container; a plunger having a plunger shaft coupled thereto, the plunger selectively placing the valve in fluid communication with the fluid container; and a solenoid coupled to the plunger shaft and moving the plunger shaft to transition the plunger between an open position and a closed position. A user interface is coupled to the valve to enable selection of at least a fluid container size and a dispensing mode.
Patent NZ-602685-A (NZ)
Title: Concentrated protein formulations and uses thereof
Inventor: CHEN TRACY T
IPC: A61P35/00
Filed: 2011-03-01
Abstract: Disclosed is a formulation comprising a concentrated protein in an amount greater than about 100 mg/mL and less than about 200 mg/mL, a tonicifier comprising a salt selected from sodium chloride, sodium gluconate, sodium lactate, or any combination thereof, and a buffer comprising a neutral nonpolar amino acid, and wherein the salt and the buffer are present in a combined amount of from about 110 mM to about 120 mM and a surfactant, wherein the formulation is hypotonic.
Patent NZ-608660-A (NZ)
Title: Anti-cd48 antibodies and uses thereof
Inventor: CLASSON BRENDAN J
IPC: C07K16/28
Filed: 2011-09-26
Abstract: Disclosed is an isolated antibody, or antigen-binding fragment thereof, that specifically binds human CD48 and blocks the interaction between human CD48 and a CD48 receptor, wherein the antibody or antigen binding fragment thereof comprises the heavy and light chains having the amino acid sequences of SEQ ID NO: 368 and 370 respectively or amino acid sequences having 90% identity to SEQ ID NO: 368 and 370. Further disclosed is an antibody comprising the complementarity determining region (CDR) domains HCDR1 (GFTFGGYA), HCDR2 (ISGSGGST), HCDR3 (AKYSNYDYFDP), LCDR1 (QSVSSSY), LCDR2 (GAS), and LCDR3 (QQYGSSPRT).
Patent NZ-618079-A (NZ)
Title: Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
Inventor: KRAYNOV VADIM
IPC: C07D417/12
Filed: 2012-05-24
Abstract: The disclosure relates to non-natural amino acids and dolastatin analogs (formula (I)) that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Further disclosed are methods for using such non-natural amino aciddolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
Patent NZ-618531-A (NZ)
Title: Aqueous catalyst sulfiding process
Inventor: POWELL JOSEPH BROUN
IPC: D21C11/00
Filed: 2012-06-13
Abstract: Disclosed herein is a method of sulfiding a sulfidable catalyst containing at least one metal or metal oxide under aqueous conditions, comprising: (i) treating said catalyst with an aqueous solution containing at least one water soluble sulfur-containing compound selected from the group consisting of sulfur containing amino acid and a by-product of a biomass digestion process to provide a treated catalyst; (b) heating said treated catalyst in the presence of hydrogen at a temperature in the range of about 150 °C to about 550 °C.
Patent NZ-628966-A (NZ)
Title: Improvements in and relating to packaging
Inventor: VAN BERLO PATRICK PETRUS ANTONIUS MARIA
IPC: B65D85/30
Filed: 2014-08-19
Abstract: A packaging system for bottles, particularly wine bottles. The packaging system comprises a base hold sheet (4) and a top hold sheet (3). Both sheets are comprised of a closed cell core board, e.g. a board comprising a honeycomb core laminated between paper sheets. The sheets contain a plurality of holes or recesses which are dimensioned to frictionally receive either the base or top of the bottles (2). The sheets and bottles may be surrounded by a layer of shrink-wrap. The sheets may be held in place by straps or interlocking elements. The recessed sheets may comprise a thickness of substantially 15mm, wherein the recess is 8-10mm deep, leaving a 5-7mm thick support portion of compressed core board. A machine is also disclosed comprising a set of punches, each punch comprising a cutting head dimensioned to cut a hole in the outer wall which matches the outer diameter of a portion of a bottle.
Patent NZ-704068-A (NZ)
Title: Gift bag with candy dispenser
Inventor: CAROL MILLER
IPC: B65D85/60
Filed: 2015-01-22
Abstract: A gift bag is provided having a generally traditional gift bag configuration with four side panels, a closed end and an open end opposite the closed end for inserting therein and removing therefrom a gift or other such item. At least one of the side panels of the gift bag is double-walled, thereby forming a cavity within the gift bag. A plurality of candy pieces is contained within the cavity. A candy dispenser is integral with the gift bag having a container into which one or more of the plurality of candy pieces may enter after exiting the cavity through a small opening therein. Once the candy dispenser is moved to an open position, a user can remove the candy therefrom and then move the candy dispenser back to a closed position in order to contain the remainder of the plurality of candy pieces within the gift bag.
Patent NZ-706631-A (NZ)
Title: Urea based skin treatment
Inventor: DAVID ROBERTS
IPC: A61P17/00
Filed: 2015-04-01
Abstract: A topical formulation for treating human skin, having: • urea; • film forming polymer; • humectant; • preservative; and • water the above ingredients being combined such that the preservative protects the formulation against bacterial invasion, the humectant assists the formulation to retain water, and the water and film forming polymer enable the urea to be applied to human skin such that the urea sits on the skin as a stable film and is gradually absorbed into the skin to alleviate dryness or cracking.
Patent NZ-709705-A (NZ)
Title: Herbicidal compositions comprising 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid
Inventor: SATCHIVI NORBERT M
IPC: C07D213/79
Filed: 2014-01-24
Abstract: Herbicidal compositions and methods using a combination of (a) a compound of formula (I) (halauxifen): or an agriculturally acceptable salt or ester thereof and (b) picloram or an agriculturally acceptable salt or ester thereof provide control of undesirable vegetation in, e.g., rice, wheat, barley, triticale, oats, rye, sorghum, corn or maize, oilseed rape, vegetables, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, industrial vegetation management or rights-of-way.
Patent NZ-709870-A (NZ)
Title: Spiro-lactam nmda receptor modulators and uses thereof
Inventor: LOWE JOHN
IPC: C07D487/10
Filed: 2014-01-29
Abstract: Disclosed are compounds, represented by formula I, having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
Patent NZ-712302-A (NZ)
Title: Biocidal composition and method for treating water or surfaces in contact with water
Inventor: VANLAER ANTOINE
IPC: A01P1/00
Filed: 2014-03-13
Abstract: The present invention relates to a biocidal composition including at least one active biocidal compound and at least one nonionic or anionic exopolysaccharide (EPS) such as dextran, xanthan, succinoglycan, or galactomannan, the active biocidal compound being selected from at least one triamine having the following formula I, R1NR2R3, formula I where R1 is an aminoalkyl radical comprising a straight or branched chain having 2 to 16 carbon atoms, R2 is a hydrogen atom or a straight or branched alkyl chain having 1 to 18 carbon atoms, and R3 is, independently from R1,an aminoalkyl radical comprising a straight or branched chain having 2 to 16 carbon atoms or a -CH2-CH2-CH2-NH-R4 radical, where R4 is a saturated or unsaturated fatty acid chain including 4 to 20 carbon atoms or a mixture of C4-C20 alkyl chains, characterized in that the biocidal composition includes, by weight and relative to the total weight of said biocidal composition, 0.5 to 90% of the biocidal compound and 0.1 to 10 % of the exopolysaccharide.
Patent NZ-734192-A (NZ)
Title: Topical liquid composition comprising melatonin
Inventor: AGOSTINETTO RITA
IPC: A61P15/06
Filed: 2016-02-15
Abstract: The present invention relates to a melatonin-based formulation, particularly a topical liquid composition of melatonin suitable for use in intrauterine washing performed during medically assisted reproduction (e.g. in vitro fertilisation - IVF). Melatonin is notoriously unstable, especially in solution. The compositions of the invention exhibit high stability, which allows them to be kept for prolonged periods before their eventual use in the inhibition or prevention of embryonic implantation failure. The invention particularly relates to the following formulation: a topical liquid composition for intrauterine washing, the composition comprising: a. 2-200 ng/ml melatonin (N-acetyl-5-methoxytryptamine), or a pharmaceutically acceptable salt or solvate thereof; b. 0.01-100 mM phosphate buffer system; c. 1x10-6-5 mg/ml methionine or cysteine; d. 0.0008-8 mg/ml arginine; e. 1-100 mg/ml sodium chloride; f. a surfactant selected from 0.001-10 mg/ml polysorbate 20 and 0.1-100 mg/ml propylene glycol; and g. water, wherein the pH of the composition is pH 7-8.5, and the composition has an osmolality of 250-350 mOsm/kg.
Patent NZ-737746-A (NZ)
Title: Floating and submersible closed-contained aquaculture farming, and method of rearing fish
Inventor: LYNGØY CATO
IPC: A01K61/90
Filed: 2016-08-12
Abstract: A fish rearing tank comprising the features of: a) an egg-shaped shell (1) with a generally vertical long axis and gradually narrowing shape towards its tip volume portion; b) said shell (1) forming a generally rigid tank; c) said shell (1) being closed; d) said shell (1) having one or more water inlets (11); e) said shell (1) having one or more water outlets (16, 29); said egg-shaped tank (1) for holding a water volume in its major lower volume portion and enclosing air in its minor, upper tip volume portion (4). Further disclosed is a method of rearing fish providing such an egg-shaped shell (1) and conducting bottom to top or reverse-circulation of water through said egg-shaped shell (1) while maintaining its air-filled volume in said tip (4). The fish rearing tank improves the welfare of farmed fish and therefore reduces the mortality rate in fish farms, reduce the risk of ecological imbalance in which case a fish farm may become artificial incubators for harmful microorganisms and parasites thereby reducing the potential to infect neighboring fish populations, reduce fish food waste, and reduce the requirement of fallowing to a minimum. The fish grid being integral to the tank serves the function of grading and counting of fish, and collecting parts or all of the fish population.
Patent NZ-749460-A (NZ)
Title: Portable physiology monitor configured to measure tympanic temperature
Inventor: MARSH LEON
IPC: G01J5/00
Filed: 2017-05-24
Abstract: An ear thermometer comprising a base 260 and an ear canal probe 214 extending from it, where the probe has centralizing sections 212 projecting from it to centralize it in the ear canal and a sound conduction channel 224 from the base to its distal end where there is also a thermopile 230. The centralizing portions and the probe position the thermopile close to the ear drum. The sound channel’s output is probe’s circumference close to the thermopile. The thermometer represent an effective use of space and allows reliable and accurate positioning of the thermopile in an inner ear close to a tympanic membrane while allowing sound to be provided to the inner ear in a space-constrained environment.
Patent NZ-749531-A (NZ)
Title: Drive module
Inventor: CALLEIJA MARK
IPC: B60B35/12
Filed: 2017-06-16
Abstract: Vehicular autonomous systems benefit from omni-directional motion because it reduces path planning dependencies, and provides additional functionality in terms of sideways motion and the ability to turn “on the spot”. Swerve drives are often used but are typically heavy, slow, relatively complex and difficult to build, have a large swept volume and thus relatively expensive. This invention relates to a drive module. The drive module includes a base and a steering assembly rotatably mounted to the base. The steering assembly is selectively rotatable about a predetermined steering axis and carries a drive train. The drive train is configured to provide a multi-stage drive reduction of the drive train, where at least a portion of the steering assembly and the drive train is spaced from the steering axis, thereby to form a void about the steering axis in which a wheel is mounted, and the drive train is adapted to support the wheel such that a centre of a contact patch of the wheel is laterally offset from the steering axis.
Patent NZ-749621-A (NZ)
Title: Method for modifying concrete slab on subsided ground
Inventor: MATSUDO Nobukazu
IPC: E04G23/02
Filed: 2017-05-31
Abstract: The present invention is a method for modifying a concrete slab on subsided ground, comprising injecting an expandable resin therebelow from an injection hole drilled in the concrete slab. The method includes steps of: on a concrete slab in an area including a region where ground subsidence has occurred, determining points to drill injection holes for injecting an expandable resin at a pitch of 0.5 to 2.0 m in a grid pattern or a staggered pattern; specifying, from the determined points, a point where the subsidence of the concrete slab is severest; injecting an expandable resin therebelow from an injection hole drilled in the specified point; and expanding the expandable resin to push up the concrete slab at most 30 mm, sequentially followed by steps of: specifying a point where the subsidence of the concrete slab is severest after the previous step has been performed; injecting an expandable resin therebelow from an injection hole drilled in the specified point; and expanding the expandable resin to push up the concrete slab at most 30 mm, thereby making the entire concrete slab a predetermined height. The points are set at a pitch of 0.5 to 2.0 m in a grid pattern or a staggered pattern so that, under easy control of the work process, the expandable resin will be injected and expanded below the concrete slab uniformly in and around the region where ground subsidence has occurred. In the case where the pitch is more than 2.0 m, even when an expandable resin is injected below two adjacent points, it may happen that the expandable resin does not spread below the gap between the points, causing a situation where a space or weak ground remains there. When the pitch is made less than 0.5 m, it may happen that the expandable resin that has been injected below the adjoining point also spreads below such a point, whereby it becomes unnecessary to inject an expandable resin below the point, or a work burden is caused due to an increase in the number of steps.
Patent NZ-751355-A (NZ)
Title: Delayed curing resin composition
Inventor: WARREN DANNY
IPC: C08L63/00
Filed: 2016-10-17
Abstract: A delayed cure, single component epoxy composition comprising a base containing cyclic anhydride and bisphenol A & bisphenol F resins with an activator preblend containing both liquid & granular bisphenol and tetraethelenepentamine (TEPA). Also disclosed are a pipe lining composite wet out with said epoxy composition which can be stored for a period of up to six months prior to installation and curing, and a method for installing said pipe lining composite.
Patent NZ-766399-A (NZ)
Title: Method and apparatus for treating hyperarousal disorders
Inventor: MARTIN DION CHARLES CHEWE
IPC: A61B5/087
Filed: 2015-10-26
Abstract: Methods and apparatus provide automated controls for a respiratory pressure therapy device, such as a servo-ventilator. For example, a controller may control the treatment pressure of the flow of air so as to servo-ventilate the patient using a servo-ventilation control gain and determine a sleep state of the patient. The control gain may be variable depending on the determined sleep state. Such methodologies may improve treatment for patients such as those suffering from sleep disordered breathing-comorbid hyperarousal disorders.