baber/WOPTO huggingface dataset:
Patent DE-69412593-T2 (DE)
Inventor: LEPPLA STEPHEN H
IPC: A61K47/48
Filed: 1994-02-14
Granted: 1999-02-18
Abstract: The present invention provides a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the anthrax protective antigen (PA) binding domain of the native anthrax lethal factor (LF) protein and a nucleotide sequence encoding an activity inducing domain of a second protein. Also provided is a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the translocation domain and LF binding domain of the native anthrax PA protein and a nucleotide sequence encoding a ligand domain which specifically binds a cellular target. Proteins encoded by the nucleic acid of the invention, vectors comprising the nucleic acids and hosts capable of expressing the protein encoded by the nucleic acids are also provided. A composition comprising the PA binding domain of the native LF protein chemically attached to a non-LF activity inducing moiety is further provided. A method for delivering an activity to a cell is provided. The steps of the method include a) administering to the cell a protein comprising the translocation domain and the LF binding domain of the native PA protein and a ligand domain, and b) administering to the cell a product comprising the PA binding domain of the native LF protein and a non-LF activity inducing moiety, whereby the product administered in step b) is internalized into the cell and performs the activity within the cell. The invention also provides proteins including an anthrax protective antigen which has been mutated to replace the trypsin cleavage site with residues recognized specifically by the HIV-1 protease.
Patent DE-69432232-T2 (DE)
Inventor: LOEPPOENEN JUSSI
IPC: H04W84/08
Filed: 1994-08-25
Granted: 2003-10-30
Abstract: PCT No. PCT/FI94/00374 Sec. 371 Date Apr. 22, 1996 Sec. 102(e) Date Apr. 22, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06395 PCT Pub. Date Mar. 2, 1995In a radiotelecommunications system where some of the subscriber stations are able to communication with one another on a direct mode channel, to direct subscriber stations to one and the same direct mode channel, a command that contains the channel identifier of the direct mode channel is sent to the subscriber stations. The subscriber stations move, in response to the channel identifier, to the direct mode channel indicated by the channel identifier, whereby each subscriber station is able to communicate with the other subscriber stations directed to same direct mode channel.
Patent DE-69433590-T2 (DE)
Inventor: EDELSON RICHARD L
IPC: A61K41/00
Filed: 1994-07-25
Granted: 2004-08-05
Abstract: Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include irradiating the tumor to release tumor-derived antigens in vivo, preparing a cellular vaccine including the isolated antigens admixed with a preparation of altered antigen presenting cells and administering the cellular vaccine to the subject. In the preferred embodiments, the antigen presenting cells are leukocytes that have been photochemically altered by subjecting the cells to photopheresis.
Patent DE-69513452-T2 (DE)
Inventor: OBERHUBER ERWIN
IPC: B61B7/02
Filed: 1995-07-08
Granted: 2000-04-13
Abstract: A driving system for cableway installations comprises at least one pathway along which a respective car (4; 4, 4') moves, and a pair of parallel carrying cables (1; 1, 1') on which a carriage (5) of the car (4; 4, 4') moves slidably. The carrying cables (1; 1, 1') are located at opposite sides of the car (4; 4, 4'), at a reciprocal distance greater than the width of the car (4; 4, 4'). On the carriage (5) of the car (4; 4, 4'), in a position symmetrical with and in the proximity of the sides of the carriage (5), there are two pairs of freely rotatable compensation pulleys (11a, 12a, 11b, 12b). For each pathway there is a first section of hauling cable (6A; 60A, 60B) and a second section of hauling cable (6B; 60A', 60B'); the first section of hauling cable (6A; 60A, 60B) comprises two parallel branches (6a, 6b; 60a, 60b, 60c, 60d) extending from a first station (2) to the car (4; 4, 4') and located at a reciprocal distance greater than the width of the car (4; 4, 4'), and the second section of hauling cable (6B; 60A', 60B') comprises two parallel branches (6c, 6d; 60a', 60b', 60c', 60d') extending from a second station (3) to the car (4; 4, 4') and located at a reciprocal distance greater than the width of the car (4; 4, 4'). The first section of hauling cable (6A; 60A, 60B) is wound on the first pair of compensation pulleys (11a, 12a), and the second section of hauling cable (6B; 60A', 60B') is wound on the second pair of compensation pulleys (11b, 12b). <MATH>
Patent DE-69524532-T2 (DE)
Inventor: SPITZ ROGER
IPC: C08F110/02
Filed: 1995-09-15
Granted: 2002-07-04
Abstract: Prodn. of solid catalysts contg. Zr atoms (but see below) comprises gas-phase treatment of an olefin polymerisation catalyst support with MCl4, where M = Zr or Hf. Also claimed is a solid catalyst for olefin polymerisation contg. at least 2.5 wt.% Zr.
Patent DE-69525041-T2 (DE)
Inventor: MATICH ANTHONY
IPC: B29K105/04
Filed: 1995-02-28
Granted: 2002-10-02
Abstract: PCT No. PCT/AU95/00100 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Feb. 28, 1995 PCT Pub. No. WO95/23682 PCT Pub. Date Sep. 8, 1995The present invention discloses structural articles such as helmets, cooler chests, pallets, building boards and a large number of diverse articles all formed from an inner, preferably air permeable, body to which a structural strength imparting skin or layer has been applied to either a single surface or opposite surfaces. The body can be expanded polystyrene, wood, particle board, cellulosic fiber cement, GECET or CARIL. The sheet or skin can be acrylonitrile butadiene styrene (ABS), polyester, styrene, or polycarbonate. Amorphous polyester (APET) is particularly preferred. A method of forming such structural articles and apparatus for use in carrying out the method are also disclosed.
Patent DE-69602003-T2 (DE)
Inventor: BALDUR ROMAN
IPC: F42B35/00
Filed: 1996-01-02
Granted: 1999-12-23
Abstract: The apparatus has a fired cartridge mounting device for holding the cartridge substantially aligned with a longitudinal axis with a primer surface of the cartridge substantially perpendicular to the axis, a cartridge microscope mounted with its optical axis substantially parallel to the longitudinal axis, a focusing mechanism for focusing the microscope to image a breech face impression on the primer surface and a firing pin impression surface in the primer surface, and an axisymmetric light source mounted to project axially symmetric light onto the breech face impression and the firing pin impression surface about the longitudinal axis. Images of the breech face and the firing pin impressions can be used for comparative analysis independently of an angular orientation of the cartridge held by the mounting device. During this analysis, a first image from a test cartridge and a second image from a computer data bank are rotated relative to one another, and a maximum correlation value for the rotated first and second images is obtained.
Patent DE-69611230-T2 (DE)
Inventor: THOREL JEAN-NO L
IPC: A61K33/30
Filed: 1996-01-09
Granted: 2001-04-05
Abstract: A cosmetic composition contains an aqueous complex nutritive base comprising a plurality of amino acids, at least one vitamin, a plurality of assimilable organic components, and at least one inorganic salt. The cosmetic composition does not contain a biological extract of animal or cellular origin, or a living nourishing substrate. A cosmetic method comprises contacting human skin with the cosmetic composition.
Patent DE-69619535-T2 (DE)
Inventor: O'DELL D
IPC: C08J3/26
Filed: 1996-08-19
Granted: 2002-08-08
Abstract: A suspension of finally divided hardened aminoplast or phenoplast resin, particularly melamine-formaldehyde resin, is prepared by mixing an aqueous solution of the resin or its precursors with a water-insoluble stabilizing agent, particularly microcrystalline cellulose; sufficient water is provided to exceed the water tolerance level of the resin and thus form a uniform emulsion or suspension of resin particles in water. Cure of the resin is then advanced such as by heating to form partially or fully cured resin particles of relatively uniform particle size.
Patent DE-69620888-T2 (DE)
Inventor: BINDER WILLIAM J
IPC: A61K38/48
Filed: 1996-11-27
Granted: 2002-08-14
Abstract: A neurotoxin is used for the manufacture of a medicament for treatment of cutaneous cell-proliferative disorders in mammals. More specifically, the invention is useful in mitigating and inducing remission of lesions associated with such disorders and in controlling related symptoms of the disorders (such as scaling and itching). The medicament containing the invertebrate neurotoxin is administered to the skin of the host at or near the site of a lesion. The preferred neurotoxin for use in the invention is Botulinum toxin, particularly Botulinum toxin A.
Patent DE-69633233-T2 (DE)
Inventor: KAPIL SANJAY
IPC: C12N15/11
Filed: 1996-06-07
Granted: 2005-08-11
Abstract: New purified and isolated bovine coronavirus (BCV) types (II and III) are described which can be used to create new modified live vaccines for administration to cattle in order to confer immunity against virulent wild-type bovine coronavirus infection. Preferably, a multivalent modified live vaccine is provided for oral-nasal administration which includes the known Type I virus and the new Types II and III virus. Hygromycin B has also demonstrated to be effective for suppressing BCV replication and thus can be administered to cattle as a treatment for the chronic disease and to suppress shedding of BCV in cattle feces.
Patent DE-69704429-T2 (DE)
Inventor: REMEROWSKI L
IPC: C09J5/02
Filed: 1997-08-05
Granted: 2001-07-05
Abstract: A method for adhesively assembling milled wood products which comprises placing adjacent to the surfaces of the pieces to be joined a continuous, non-perforated metallic foil strip, which absorbs electromagnetic waves. The strip, which is contiguous with a heat activatable adhesive material, is positioned between the pieces and exposed to electromagnetic waves while the pieces are held together to form a bonded relationship between the pieces.
Patent DE-69705667-T2 (DE)
Inventor: MARCHIONNI GIUSEPPE
IPC: C07C41/22
Filed: 1997-04-15
Granted: 2002-05-08
Abstract: Process for preparing perfluoropolyethers with bromo- or iodo-containing end groups, respectively, by subjecting a peroxidic perfluoropolyether to thermal treatment, in absence of UV radiations, at temperatures from 120 DEG C to 280 DEG C in the presence of bromo- or iodo-containing compounds having, respectively, the following general formulas: T T'T'' C Br wherein T,T',T'' equal to or different from each other are selected from Br, F, H or R'f, wherein R'f is a perfluoroalkylic chain from 1 to 8 carbon atoms; R R'R''C I wherein R, R',R'', equal to or different from each other can be I (iodine), H, F or R'f, wherein R'f has the meaning indicated above.
Patent DE-69706776-T2 (DE)
Inventor: SCHAPIRA JOSEPH
IPC: A01N37/40
Filed: 1997-07-04
Granted: 2002-07-04
Abstract: A food-grade bactericidal composition comprises (a) a monoester of a C10 or C12 saturated fatty acid and glycerol together with (b) an alkyl ester of p-hydroxybenzoic acid and (c) an effective amount of n-propyl gallate. Preferred compositions comprise 5-70 (preferably 8-60) % (c), 0.05-50 (preferably 0.1 - 47) % (a) and 5-95 (preferably 7-91) % (b). The compositions are preferably used in the form of solutions in water/ethanol, water/isopropanol, water/n-propanol or propylene glycol. (a) is preferably monocaprin or monolaurin. (b) is preferably the ethyl- or n-propyl ester of p-hydroxybenzoic acid.
Patent DE-69720481-T2 (DE)
Inventor: AGRAWAL SUDHIR
IPC: A61K38/00
Filed: 1997-09-10
Granted: 2004-02-12
Abstract: The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides modified oligonucleotides that inhibit gene expression and that produce fewer side effects than conventional phosphorothioate oligonucleotides. In particular, the invention provides modified CpG-containing oligonucleotides that result in reduced splenomegaly and platelet depletion when administered to a mammal, relative to conventional CpG-containing phosphorothioate oligonucleotides. The invention further provides methods for using such oligonucleotides to modulate gene expression in vivo, including such use for therapeutic treatment of diseases caused by aberrant gene expression.
Patent DE-69721567-T2 (DE)
Inventor: MULDER JAN
IPC: A01C1/04
Filed: 1997-12-12
Granted: 2004-03-25
Abstract: A method for cultivating a plant, starting from seed or a vegetatively reproduced starting material, wherein use is made of a block (1) with a positioning site (2) on the upper surface for placing of the seed (Z), and wherein a quantity of liquid with plant-protecting properties is placed on the positioning site (2), whereby the plant is still effectively protected without danger to the surrounding area.
Patent DE-69727920-T2 (DE)
Inventor: MURPHY COLIN
IPC: F16B43/00
Filed: 1997-03-21
Granted: 2005-03-17
Abstract: A circular thin metal or thermoplastic disc stress plate has an annular stiffening rim and groove and a central opening. Three equilateral and symmetrically oriented elongated nail-like members depend from the plate at the rib and groove inclined in diverging relation relative to a vertical axis normal to and central the plate on a conical surface of revolution. The members extend radially beyond the perimeter of the stress plate projected onto the members forming an annular attachment region to a cementitious substrate significantly greater than the area subtended by the stress plate. Two or more than three members may be used in the alternative. The nail-like members have conical tips which may be any shape and blunt. The members preferably are circular cylinder steel, may be other transverse sectional shapes, and are driven individually or simultaneously into the substrate either through holes in the plate or penetrate the plate material by a power operated nail driving tool. The members may have heads of different shapes which are substantially recessed against the rib in the groove.
Patent DE-69735484-T2 (DE)
Inventor: COUPLAND JOHN
IPC: C12N5/10
Filed: 1997-06-23
Granted: 2006-10-12
Abstract: A flowering characteristic of a plant, particularly the timing of flowering, is controlled by the expression of the Late Elongated Hypocotyl (LHY) gene of Arabidopsis thaliana or a mutant, variant, allele, derivative, or homologue thereof. Over-expression may be used to delay flowering in a transgenic plant. The promoter of the gene regulates transcription in accordance with the circadian rhythm and may be used to control expression of genes whose products are only required or desired at certain times of the day.
Patent DE-69800913-T2 (DE)
Inventor: TACCHELLA CLAUDIO
IPC: G05B19/409
Filed: 1998-07-23
Granted: 2001-09-27
Abstract: A monitoring device for a grinding machine wherein, after selecting a programming mode, an existing program can be modified or a new program can be constructed. Access to the programming mode comprises activation of a first programming level (200) in which a plurality of macro-icons are displayed, each representing a respective elementary cycle for machining a part for grinding. The operator has immediate access, with possibility of display and amendment, to the data characterising each cycle (the data being mainly defined by the type of machining associated with the said elementary cycle and with the physical position of the grinding disc in each cycle). The time sequence of cycles, the number and the arrangement of cycles can also be modified by simple operations of adjustment and modification used in conventional graphics so as to obtain a new sequence of elementary cycles. The operator can also move to a second programming level (290) whereby all the parameters relating to each selected elementary cycle can be defined in great detail. <IMAGE>   <IMAGE>
Patent DE-69819709-T2 (DE)
Inventor: NAVOT YORAM
IPC: B67B7/48
Filed: 1998-01-08
Granted: 2004-09-30
Abstract: A device (2) for effecting opening of a sealed bag-like flexible packet (4) and for dispensing its contents. The device (2) includes two interconnected limbs (6, 8), each limb includes an inside (12) and an outside (10) surface, and is of a size at least equal to one dimension of the packet (4), to facilitate placing the packet (4) in between the limbs (6, 8). The device (2) also includes a mechanism (32, 36) located at the end portions of the limbs (6, 8) facilitating piercing or cutting the packet (4) to form an opening (38), allowing the contents to be dispensed upon effecting a sequential squeezing action on the packet (4) starting from a point distant from the opening (38).
Patent DE-69824794-T2 (DE)
Inventor: JACOBS ANTONIUS ARNOLDUS CHRIS
IPC: A61K39/085
Filed: 1998-07-27
Granted: 2004-11-25
Abstract: The present invention relates to the use of live attenuated bacteria of the species Streptococcus equi for the manufacture of vaccines for systemic application for combating Streptococcus equi infection.
Patent DE-69827168-T2 (DE)
Inventor: HANSEN HARBO
IPC: A23L29/256
Filed: 1998-08-27
Granted: 2006-02-23
Abstract: Carrageenan compostions comprising from about from about 79 mol % to about 95 mol % iota carrageenan and from about 0.1 mol % to about 10 mol % nu carrageenan, and carrageenan and compositions which exhibit elastic modulus, G'-1 Hz at 5 DEG  C., of greater than about 200 Pa, elastic modulus, G'-1 Hz at 25 DEG  C., of less than about 200 Pa, viscous modulus, G''-0.2 Hz at 5 DEG  C., of from about 5 Pa to about 25 Pa, and melting point of less than 60 DEG  C., in a 1.2 wt % aqueous gel, and methods of producing the same.
Patent DE-69831959-T2 (DE)
Inventor: MARTIN R
IPC: A61K31/44
Filed: 1998-08-07
Granted: 2006-07-27
Abstract: The present invention relates to treatment of pain with a new class of analgesic compounds. More particularly, the present invention relates to a method for reducing pain of a patient involving administering to a patient an effective amount of an aryl substituted olefinic amine compound. In one aspect, the inventive method of reducing pain in a patient involves use of metanicotine compounds as the analgesic agent.
Patent DE-69900858-T2 (DE)
Inventor: RAMIN ROLAND
IPC: A61Q1/02
Filed: 1999-11-04
Granted: 2002-11-07
Abstract: The procedure comprises application of the first layer of 1st film-forming composition comprising 1st film-forming polymer in cosmetically acceptable medium, followed by application of second layer, consisting of spherical or ovoidal particles, non-soluble in first layer medium, onto at least part of the first layer, before its drying. The procedure comprises application of the first layer of 1st film-forming composition comprising 1st film-forming polymer in cosmetically acceptable medium, followed by application of second layer, consisting of spherical or ovoidal particles of density 800-10000 (preferably 1000-3000) kg/m<3> and size 2.5 microns to 5 mm (preferably 50 microns to 2 mm), non-soluble in first layer medium, onto at least part of the first layer, before its drying. Solid particles can be made of glass, inorganic or polymeric material, metal (steel, copper, brass, chrome) wood, marble, onyx, jade, mother-of-pearl, precious stones, amethyst or aquamarine (preferably of glass micro-spheres). The procedure may also comprise application of third layer of 2nd film-forming composition, comprising at least one 2nd film-forming polymer in cosmetically acceptable medium, onto second layer. The 1st and/or 2nd composition may contain solvent, the 1st and 2nd polymer may be dissolved or dispersed, in form of particles, in cosmetically acceptable medium, and respective contents of 1st and 2nd film-forming polymer in 1st and 2nd composition are 1-70 (preferably 10-40) wt.%. The 1st and/or 2nd composition may also contain at least one additive selected from auxiliary film-forming agent (0.5-20, preferably 2-10 wt.%), thickener, spreading and wetting agents, dispersant, anti-mousse agent, preservative, UV-filter, colorant, pigment, surfactant, hydratant, perfumer, neutralizer, stabilizer and antioxidant. Any or both of 1st and 2nd composition can be in form of nail varnish, cream blusher or eyelid color, foundation, lipstick or body make-up, and second layer of solid particles is deposited preferably by sprinkling (powdering) onto the first layer. Independent claims are also included for: (1) Make-up obtained using procedure as claimed; (2) make-up kit, comprising 1st and optional 2nd film-forming composition as claimed, and solid particles as claimed, in form as claimed and preferably in distinct separate containers, as well as application means e.g. brushes, sponges, pencils and pen-like applicators; (3) make-up support bearing make-up as claimed, e.g. in form of false nails; and (4) the use of film-forming composition as claimed and/or solid particles as claimed to produce surface relief type make-up, of good staying power.
Patent DE-69911255-T2 (DE)
Inventor: MAIOLANI MARK
IPC: G06F11/14
Filed: 1999-12-22
Granted: 2004-04-01
Abstract: A microprocessor module is arranged to be coupled to a communications network having a number of distributed modules. Each module is arranged to transmit status signals relating to the status of other modules. The microprocessor module includes a microcontroller arranged to control functions of the module and a reset arrangement coupled to the network and arranged for providing a reset signal to reset the microcontroller in dependence upon a reset condition. The reset condition is determined by a voting scheme applied to the status signals received from the plurality of modules.
Patent DE-69914348-T2 (DE)
Inventor: CECUR MAJO
IPC: F01L1/24
Filed: 1999-10-05
Granted: 2004-11-04
Abstract: A valve train assembly for an internal combustion engine comprises a common carrier which supports the engine's rocker arms by means of individual fulcra each of which preferably forms a part of a hydraulic lash adjuster. Each rocker arm is constructed by deforming a metal sheet into a channel shape, the deformation also forming a part-spherical surface for mating with a surface of the fulcrum. The rocker arms can be snap-fitted on to the fulcra by means of an apertured, resilient sheet.
Patent DE-69917389-T2 (DE)
Inventor: KAO YO-HONG
IPC: G10L15/28
Filed: 1999-08-12
Granted: 2005-06-02
Abstract: A memory management method is described for reducing the size of memory required in speech recognition searching. The searching involves parsing the input speech and building a dynamically changing search tree. The basic unit of the search network is a slot. The present invention describes ways of reducing the size of the slot and therefore the size of the required memory. The slot size is reduced by removing the time index, by the model_index and state_index being packed and by a coding for last_time field where one bit represents a slot is available for reuse and a second bit is for backtrace update.   <IMAGE>
Patent DE-69918132-T2 (DE)
Inventor: HARVEY C
IPC: C12Q1/6886
Filed: 1999-07-23
Granted: 2005-07-07
Abstract: A simplified method for preparing nucleic acid, preferably spliced mRNA, from a biological sample that is suitable for amplification is disclosed. A method of detecting and measuring the amount of one or more species of spliced mRNA present in the sample, following nucleic acid amplification, is disclosed.