baber/WOPTO huggingface dataset:
Patent FI-933149-A0 (FI)
Inventor: DUMAITRE BERNARD ANDRE
IPC: C07D401/12
Filed: 1993-07-09
Abstract: There are provided compounds of the general formula (I) <CHEM> wherein R<0> represents a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy, C1-4alkylthio, amino or nitro group; p represents 1; or when R<0> represents C1-4alkoxy may also represent 2 or 3; R<1> represents a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or C1-4alkylthio group;  R<2> represents a hydrogen atom or a C1-4alkyl group; A represents an oxygen or a sulphur atom, a bond or a group (CH2)1NR<9> (where 1 represents zero or 1 and R<9> represents a hydrogen atom or a methyl group); B represents a C1-4alkylene chain optionally substituted by a hydroxyl group, except that the hydroxyl group and moiety A cannot be attached to the same carbon atom when A represents an oxygen or sulphur atom or a group (CH2)1NR<9>, or when A represents a bond B may also represent a C2-4alkenylene chain;  R<3> represents a hydrogen atom or a C1-4alkyl group;  m represents 1 or 2; R<4> represents a hydrogen or a halogen atom, or a C1-4alkyl, C1-4alkoxy or C1-4alkylthio group;  R<5> represents a hydrogen atom or a C1-4alkoxy group; R<6> represents a hydrogen atom or a C1-4alkyl or C1-4alkoxy group R<7> represents a hydrogen atom or R<3> and R<7> together form a group -(CH2)n-where n represents 1 or 2;  R<8> represents a hydrogen atom or a C1-4alkoxy group;  the group <CHEM> is attached at the benzene ring 3 or 4 position relate to the carboxamide substituent, provided that when the group is attached at the benzene ring 3 position then R<6> must be attached at the benzene ring 6 position;  and salts and solvates thereof. The novel compounds of formula (I) can sensitize multidrug-resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an antitumour drug.
Patent FI-934305-A0 (FI)
Inventor: ATKINSON PAUL ROBERT
IPC: C12N9/48
Filed: 1993-09-30
Abstract: The present invention is directed to a novel dipeptidylaminopeptidase isolated from the cellular slime mold, Dictyostelium discodeum. The novel DAP enzyme, dDAP, displays an activity which is somewhat similar to both DAP-I and DAP-III but is highly distinctive from these enzymes in physical and other enzymatic characteristics. The invention is also directed to methods for using the dDAP enzyme to remove dipeptides from the N-terminus of recombinantly produced precursor proteins or peptides. In addition, the invention relates to methods for isolating and purifying the dDAP enzyme from cultures of D. discoedeum.
Patent FI-943353-A0 (FI)
Inventor: SCHWARZE JAN
IPC: E03C1/32
Filed: 1994-07-14
Abstract: The device has a tension disk (3) which is non-rotatably arranged on a bolt (2). The bolt is rotatably located in a recess (1a) of the sanitary object (1). The tension disk is provided with a spiral section-formed tightening surface and engages in a stirrup-shaped counter piece (4). On the outward face surface of the bolt a key surface (2a), pref. an inner hexagon, is arranged for a tool. The bolt is rotatably located in a bearing part (6) inserted in the recess, pref. of plastics. The bearing part is provided with a flange (6a) supporting on the inside of the sanitary ceramic object.
Patent FI-956180-A0 (FI)
Inventor: KARLSSON KARL-GUSTAV
IPC: B65D5/72
Filed: 1995-12-21
Abstract: The present invention relates to a packaging unit for sheet-like material, such as paper of A4 size, comprising a box (1) having a lid (2) which are both of rectangular shape and include a centre part (3, 6, 14, 10), two side parts (4, 7, 15, 11) and two end wall parts (5, 8, 16, 12) or, in the case of the box, alternatively four end wall parts (17), and are easily separated, wherein the box and/or the lid includes/include a moisture barrier. The unit is characterized in that the lid centre part (upper part) is at least partially broken through (perforated) along at least one line (9, 13).
Patent FI-960169-A0 (FI)
Inventor: ARIAGNO DANIEL
IPC: C09K3/18
Filed: 1996-01-15
Abstract: Functionalised grafted polyorganosiloxanes comprising grafted copolymer units from (a) an ethylenically unsatd. monomer capable of radical polymerisation and (b) functionalised polyorganosiloxane contg. units of formula RaYbXcSiO(4-a-b-c)/2 (I) are used as anti-adhesives and/or water repellents. R = 1-18C alkyl, 2-20C alkenyl or 6-12C aryl or aralkyl, opt. substd. with halogen; X = reactive function linked to Si by a Si-C or Si-O-C bond; Y = ethylenically unsatd. hydrocarbon gp. opt. contg. O or N as heteroatoms, linked to Si in (I) by a Si-C bond, and able to react radically with the monomer (a); a,b,c = 0-3; a + b + c = 0-3. The content of SiO4/2 units is below 30 mols %, the number of (I) units in which Si carries X and/or Y is such that the polyorganosiloxanes contain, w.r.t. 100 g of (I), at least 5 (10-500) milli-equivs. of X and at least 5 (10-500) milli-equivs. of Y, and the X unit is a 1-20C epoxy-functional hydrocarbon gp.
Patent FI-962893-A0 (FI)
Inventor: TOMAC STEPHAN
IPC: A61H1/00
Filed: 1996-07-18
Abstract: A device for passive-motion treatment of the human body comprises: a body support platform (12) having a foot end and a head end and including a base section (14) and a back support section (16) which is movable relative to the base section (14) along a longitudinal axis (L) extending between the foot end and the head end of the body support platform (12). Means (15) may be provided for locking the lower body portion of a patient to the base section (14) of the body support platform (12) with the patient lying on the body support platform with his back resting on the back support (16), and for applying traction to the patient's spine under the force of gravity. The back support section (16) or at least one subsection (17-21) thereof is resiliently movable relative to the base section (14) and connected with a vibrator (23-29) by which the subsection is caused to vibrate in one or more directions.
Patent FI-973918-A0 (FI)
Inventor: PELLONPERAE MARKO
IPC: H03F3/24
Filed: 1997-10-09
Abstract: A method of compensating delay in an linearization loop of a power amplifier and a linearization arrangement of a power amplifier, which arrangement includes an I/Q modulator, one or more power amplifiers to be linearized and generating delay, and a feedback loop including an I/Q demodulator when the I/Q modulator and the I/Q demodulator derive an oscillator frequency from the same local oscillator. In accordance with the invention, the delay generated the power amplifier in the feedback is compensated by delaying a local oscillator signal applied to the I/Q demodulator. The delay of the local oscillator signal applied to the I/Q demodulator is generated by an amplifier optimized to have a great delay, preferably by a small-signal amplifier.
Patent IL-67658-A0 (IL)
Title: Preparation of delta 5,7-steroids
IPC: C07J1/00
Filed: 1983-01-11
Abstract: The invention relates to a method of preparing  DELTA 5,7-steroids, in particular 7-dehydrocholesterol compounds, of the general formula: <IMAGE>  wherein R is a hydrogen atom, a hydroxy group, optionally etherified with a C1-C4 alkanol or esterified with a C1-C4 alkane carboxylic acid, a C2-C5 alkanoyl group, optionally ketalized with a C1-C4 alkanol, or a branched or non-branched, saturated or unsaturated C1-C10 alkyl group, optionally substituted with one or more fluorine atoms or hydroxy groups, which hydroxygroup or groups is (are) optionally etherified with C1-C4 alkanol(s) or esterified with C1-C4 alkane carboxylic acid(s), and R1, R2 and R3 are equal or different and represent hydrogen atoms or hydroxy groups, optionally etherified with C1-C4 alkanols or esterified with C1-C4 alkane carboxylic acids, or wherein R1 and R2 together constitute a C2-C4 alkylene dioxy group, by dehydrobrominating 7-bromo- DELTA 5-steroids under the influence of a fluoride as a base in an organic solvent.
Patent IL-70859-A0 (IL)
Title: Thiazine derivatives,their preparation and pesticidal compositions containing them
IPC: C07D279/06
Filed: 1984-02-02
Abstract: Substituted 2-nitromethylene-tetrahydro-2H-1,3-thiazines of formula:in which n is 0 or 1; m is 0 or 1; X is oxygen or sulphur; and R is alkyl, alkenyl or alkynyl optionally substituted by one or more of the same or different substituents selected from halogen atoms and hydroxy, thiol, acyloxy, acylthio, alkoxy, alkoxyalkoxy, haloalkoxy, and optionally substituted phenyl groups; have useful pesticidal properties.
Patent IL-85613-A0 (IL)
Title: Platelet related growth regulator
IPC: C12P21/02
Filed: 1988-03-02
Abstract: Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp60 src and induce the release of a 52 kD polypeptide from neoplastic cells. Individual polypeptides may be isolated from mammalian blood platelets by selected extraction and purification procedures, may be synthesized or produced by hybrid DNA technology.
Patent IL-86629-A0 (IL)
Title: Process for preparing sertraline intermediates
IPC: C07C67/00
Filed: 1988-06-06
Abstract: A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone and ultimately, to cis-(1S)(4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrah ydro-1-naphthaleneamine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds. There is also disclosed a novel process for converting 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone directly to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone, as well as an alternate novel process for converting 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid directly to this same key intermediate.
Patent FI-20000888-A0 (FI)
Inventor: RYHAENEN TAPANI
IPC: H01H47/00
Filed: 2000-04-13
Abstract: The invention relates to a controlling of micromechanical elements. Especially the invention relates to the controlling of the micromechanical switches. According to a method for controlling at least one micromechanical element a first control signal and a second control signal are fed to the micromechanical element. The second control signal is arranged to set the micromechanical element to an active state and the first control signal is arranged to hold the micromechanical element in the active state. An arrangement for controlling at least one micromechanical element (402) contains at least means for generating at least a first control signal and a second control signal, means for raising a voltage level of at least the second control signal and means for feeding the first control signal and the second control signal with raised voltage level to the micromechanical element. By means of the invention lower voltage levels can be used in micromechanical applications. <IMAGE>
Patent FI-20011721-A0 (FI)
Inventor: KOIVUNEN KARI
IPC: E04B1/21
Filed: 2001-08-28
Abstract: A joint for joining reinforced concrete pillars (10a, 10b) together, wherein a first connecting element (20a) comprises a cylindrical projecting part (30) provided with an annular groove (31) and a second connecting element (20b) consists of a cavity (40, 63) provided with an annular groove (41, 65). An annular spring (50) interlocks the grooves (31, 41, 65). The groove of the joining element of at least one of the objects to be joined is provided with a wedge-like part (34, 44) on which the spring-like locking element (50) is wedged, forming a joint free of backlash. <IMAGE>
Patent FI-20021555-A0 (FI)
Inventor: MILOSAVLJEVIC ZLATOLJUB
IPC: H01Q5/10
Filed: 2002-08-30
Abstract: The invention relates to an adjustable planar antenna especially applicable to mobile terminals, and to a radio device provided with that kind of antenna. The basic structure of the antenna is PIFA. On a surface of a dielectric part (205) there is placed a strip conductor (230) so that this has a significant electromagnetic coupling to the radiating plane (220). The strip conductor can be connected by a switch (SW) to the ground plane. When the switch is closed, the electric length of the radiating plane is changed, measured from the short point (S). In which case also the antenna's resonance frequency is changed. The change depends on the place and the size of the strip conductor. In the case of a multi-band antenna the strip conductor can be placed so that it has a remarkable electromagnetic coupling to one or more radiating elements (B1, 226). The adjusting of planar antenna is performed by means of small additive components, which do not presume changes in the antenna's basic structure and do not enlarge the antenna. <IMAGE>
Patent FI-20050493-A0 (FI)
Inventor: KALLIO JUHA
IPC: H04L47/2416
Filed: 2005-05-09
Abstract: Quality of a connection between a terminal and a gateway is monitored in the gateway. The gateway informs a core network element handling signaling relating to the connection about the quality of the connection. The core network element triggers an access network control element to inform the terminal about the quality of the connection. The gateway or the core network element may determine when to trigger the access network control element. Upon receiving triggering information from the core network element, the access network control element informs the terminal about the quality of the connection for indicating changes in the quality of connection between the terminal and the gateway.
Patent IL-101786-A0 (IL)
Title: Thiomarinol,processes for the preparation thereof,and pharmaceutical compositions containing the same
IPC: C12N1/20
Filed: 1992-05-05
Abstract: The present invention relates to a novel antibacterial compound of formula (I) from the genus Alteromonas and which shares structural similarity with the pseudomonic acids. <CHEM> i
Patent IL-107563-A0 (IL)
Title: Compositions for the regulation of cytokine activity
IPC: A61P29/00
Filed: 1993-11-10
Abstract: Substances comprising a N-sulfated or N-acetylated or non-sulfated N-acetylated 4-deoxy-4-en-iduronoglucosamine in substantially purified form, including compositions containing same and their uses are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of Tumor Necrosis Factor Alpha (TNF- alpha ) can be either inhibited or augmented selectively by administration to the host of effective amounts of substances or their compositions comprising specific oligosaccharides in substantially purified form, in relation to the treatment or prevention of a medical condition which is selected from the group consisting of insulin-dependent diabetes mellitus, periodontal disease, inflammatory bowel disease, skin diseases, uveitis, rheumatic diseases, chronic inflammation, multiple sclerosis, lupus erythematosus, atherosclerosis, arthritis, vasculitis, allergy and neoplasia. The invention also relates to the initiation of a desirable immune system-related response by the host to the presence of activators, including pathogens, including viral infection, bacterial infection or fungal infection. <IMAGE>
Patent IL-112110-A0 (IL)
Title: Octahydro-1h-isoindoles and pharmaceutical compositions containing them
IPC: C07D401/04
Filed: 1994-12-22
Abstract: The 4-arylisoindoles of the following formula are effective analgesics:    <IMAGE>  I  including the purified stereoisomers and pharmaceutically acceptable salts thereof, wherein   <IMAGE>    <IMAGE>   Rb is hydroxy or C1-5 alkylcarbonyloxy.
Patent IL-117157-A0 (IL)
Title: Preparation of factor ix from biological sources
IPC: C12N9/64
Filed: 1996-02-16
Abstract: PCT No. PCT/EP96/00636 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 14, 1996 PCT Pub. No. WO96/27003 PCT Pub. Date Sep. 6, 1996A process for the preparation of factor IX from a biological source by chromatography involves prior treatment with ammonium sulfate as a protein precipitant at a concentration of from 1.5-2.3 mol/l.
Patent IL-121917-A0 (IL)
Title: Method of preventing animal diseases and promoting animal growth and development
IPC: A01K67/02
Filed: 1996-08-16
Abstract: A method of promoting growth and improving imumune function of animals is described in the present invention, in which a bioactive agent extracted from seed cake is used as feed additive.
Patent IL-121982-A0 (IL)
Title: Method of manufacturing a hollow blade for a turbomachine
IPC: F01D5/18
Filed: 1997-10-15
Abstract: The procedure consists of assembling the primary components (11) and placing them in a furnace, subjecting to pre-baking and eliminating the binding agent of the anti-diffusion product. Then, without moving the components, the interior of the blade assembly (14) is subjected to a vacuum and a simultaneous increase in temperature to produce a permanent plastic deformation of the components. The interior of the blade assembly, made from a titanium alloy, is kept under the vacuum while an isostatic pressure is applied to the exterior, with the pressure and temperature conditions maintained to ensure a compaction of the anti-diffusion product and a pre-welding of the non-coated zones of the diffusion barrier. The assembly is subsequently inflated by gas pressure and superplastically moulded before subjecting to final machining.
Patent IL-123536-A0 (IL)
Title: 5-HT3 Receptor antagonists for dyskinesia
IPC: A61K31/4184
Filed: 1996-09-16
Abstract: The invention provides the use of a 5-HT3 receptor antagonist or a pharmaceutically acceptable derivative thereof for use in the treatment of dyskinesia.
Patent IL-129652-A0 (IL)
Title: Acylated cyclodextrin derivatives
IPC: A61K47/40
Filed: 1997-10-06
Abstract: A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of said cyclodextrin are acylated with acyl groups where at least one of said acyl groups comprise a free carboxylic group.
Patent IL-144158-A0 (IL)
Title: Outlet for connecting an analog telephone set to a digital data network carrying voice signals in digital form
IPC: H04Q11/00
Filed: 2001-07-05
Abstract: The present invention relates to a component for a data network. The component comprises a wiring connector connectable to wiring for connecting to the data network, a modem allowing for data communication over the wiring, a data connector connectable to a data terminal equipment unit, and a telephone connector connectable to a telephone unit for coupling an analog telephone signal to the telephone unit. The component further comprises an adapter which is connected to said telephone connector and operative to convert Voice over Internet Protocol (VoIP) packet telephony to the analog telephone signal, and a multi-port unit with a first port coupled to said data connector, a second port coupled to said modem and a third port coupled to said adapter, wherein said multi-port unit is operative to pass the VoIP packet telephony between said second and third ports. The adapter, the data connector, the telephone connector and the multi-port unit are included together within the single component.
Patent IL-155423-A0 (IL)
Title: Cytochrome p450 monooxygenases consisting of thermophilic bacteria
IPC: C12P7/00
Filed: 2001-10-16
Abstract: The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genus Thermus sp., to nucleotide sequences encoding them, to the recombinant production of these monooxygenases and to their use for the microbiological oxidation of organic compounds.
Patent IL-155453-A0 (IL)
Title: Moving nozzle ink jet actuator
IPC: B41J2/055
Filed: 2001-10-19
Abstract: The invention concerns an ink jet printhead including:a plurality of nozzles each adapted to eject drops of ink 14 toward a surface to be printed; wherein,each of the nozzles has an external actuator 10 and an apertured roof portion 6; the roof portion 6 defining an inner surface for contacting the ink and an opposing outer surface operatively connected to the external actuator 10 such that the actuator 10 moves the roof portion 6 away from the surface to be printed to eject the ink 14.
Patent IL-161548-A0 (IL)
Title: Method of replacing an abradable portion on the casing of a turbojet fan
IPC: B29C63/00
Filed: 2004-04-21
Abstract: The procedure is designed for use on a turbojet engine with a rotary section that has a fan stage with a hub and series of blades at the forward end of its shaft inside an annular casing (60) with an abradable layer (80) stuck to its inner surface (70). It consists of removing the worn abradable layer, cleaning and applying adhesive (82) to the casing's inner surface, and fitting the new abradable layer against it. The inner, sealing surface (84) of the abradable layer is then fitted with a heating band (100), to which a pressure is applied by at least three supporting sectors (110) with inflatable chambers (120), the sectors being held in place by brackets (125) attached to the fan casing by fixings (96).
Patent IL-175521-A0 (IL)
Title: Process for the cultivation of microorganisms of the genus thraustochytriales
IPC: C12P7/64
Filed: 2006-05-09
Abstract: The invention relates to an optimized method for the production of PUFAs by cultivating microorganisms belonging to the group of Stramenopiles in a fermentation medium that is pH-stabilized using calcium carbonate and comprises 3-15 g/L CaCO3, whereupon the PUFAs are isolated from the microorganisms and/or the medium. The invention particularly relates to novel optimized media having a different CaCO3 content. By using adequate quantities of CaCO3, the process can be significantly simplified during fermentation while greater quantities of DHA can be obtained at an increased oil content in the biomass. They allow microorganisms belonging to the Stramenopiles to be fermented without controlling the pH, thereby substantially improving and significantly simplifying PUFA production.
Patent IL-181312-A0 (IL)
Title: Refolding transforming growth factor beta family proteins
Filed: 2007-02-13
Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.
Patent IL-183558-A0 (IL)
Title: Optical disc security device having a magnetically actuable locking mechanism
Filed: 2007-05-30
Abstract: Systems and apparatus for a security device for an article having a constrained elongate member are disclosed.