Patent SG-11201901729Y-A (SG)
Title: Fused bicyclic sgc stimulators
Inventor: RENNIE GLEN ROBERT
IPC: C07D487/04
Filed: 2017-09-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111 111111111101111101011H01111111111111111111111111111110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/045276 Al 08 March 2018 (08.03.2018) WI P0 I P C T (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 487/04 (2006.01) A61K 31/4985 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, CO7D 471/04 (2006.01) A61P 25/28 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/US2017/049834 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 01 September 2017 (01.09.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/382,942 02 September 2016 (02.09.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/423,445 17 November 2016 (17.11.2016) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/468,598 08 March 2017 (08.03.2017) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 62/482,486 06 April 2017 (06.04.2017) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: IRONWOOD PHARMACEUTICALS, INC. [US/US]; 301 Binney Street, Cambridge, MA 02142 (US). Declarations under Rule 4.17: (72) Inventors: RENNIE, Glen, Robert; 46 Elmwood Street — as to applicant's entitlement to apply for and be granted a #2, Somerville, MA 02144 (US). IYENGAR, Rajesh, R.; patent (Rule 4.17(0) 23 Stratford Road, West Newton, MA 02465 (US). LEE, — as to the applicant's entitlement to claim the priority of the Thomas, Wai-Ho; 665 Lowell Street, Unit 60, Lexing- earlier application (Rule 4.17(iii)) ton, MA 02420 (US). NAKAI, Takashi; 7 Gardner Street, Published: Newton, MA 02458 (US). MERMERIAN, Ara; 50 Milton — with i nternational Street, Waltham, MA 02453 (US). JIA, James; 4 Jeanette search report (Art. 21(3)) Avenue, Belmont, MA 02478 (US). IM, G-Yoon, Jamie; 931 Massachsetts Avenue, Apt. 604, Cambridge, MA 02139 (US). RENHOWE, Paul, Allan; 19 Sky View Road, Sud- bury, MA 01776 (US). JUNG, Joon; 111 Wendell Road, Newton, MA 02459 (US). GERMANO, Peter; 36 Bontem- po Road, Newton, MA 02459 (US). IYER, Karthik; 30 Cambridge Park Drive, Apt. 6121, Cambridge, MA 02140 (US). BARDEN, Timothy, Claude; 19 Intervale Road, Salem, MA 01970 (US). TANK, Kim; 256 Slade Street, Belmont, MA 02478 (US). (74) Agent: DAVIS, Steven G. et al.; McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (54) Title: FUSED BICYCLIC SGC STIMULATORS (57) : The present disclosure relates to stimulators of soluble guanylate cy- clase (sGC), pharmaceutical formulations comprising them and their uses thereof, G SSZ alone or in combination with one or more additional agents, for treating various dis- 1::+ (jc)p 1 s_ m11 increase in the concentration of nitric oxide (NO) or an increase IN ei If) \(-. ' \ r‘ eases, wherein an `c . E X 0 A 1 Q f D 10\ in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an up- k\" la — regulation of the NO pathway is desirable. The compounds are of Formula I: X - - N 71- y— ..;_ ...- - - 0 (I) 0 ei (An C