Patent SG-11201807991Q-A (SG)
Title: Use of nucleosome-transcription factor complexes for cancer detection
Inventor: MICALLEF JACOB VINCENT
IPC: G01N33/68
Filed: 2017-03-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111011101111010101111011111111011110111 International Bureau ... .... ..Yjd ..... ...,/ (10) International Publication Number (43) International Publication Date WO 2017/162755 Al 28 September 2017 (28.09.2017) WIP0 I PCT — (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) (72) (74) International Patent Classification: (81) Designated States (unless otherwise indicated, for every GO1N 33/574 (2006.01) G01N 33/68 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/EP2017/056851 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 22 March 2017 (22.03.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Priority Data: ZA, ZM, ZW. 1604806.8 22 March 2016 (22.03.2016) GB (84) Designated States (unless otherwise indicated, for every Applicant: BELGIAN VOLITION SPRL [BE/BE]; 22 kind of regional protection available): ARIPO (BW, GH, Rue Phocas Lejeune, BE-5032 Isnes (BE). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Inventors: MICALLEF, Jacob Vincent; c/o Belgian Vo- lition SPRL, 22 Rue Phocas Lejeune, BE-5032 Isnes (BE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, REIS-FILHO, Jorge; c/o Belgian Volition SPRL, 22 Rue DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Phocas Lejeune, BE-5032 Isnes (BE). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Agents: AITKEN, Elizabeth et al.; Sagittarius IP, Three GW, KM, ML, MR, NE, SN, TD, TG). Globeside, Fieldhouse Lane, Marlow, Buckinghamshire SL7 1HZ (GB). [Continued on next page] — = Title: USE OF NUCLEOSOME-TRANSCRIPTION FACTOR COMPLEXES FOR CANCER DETECTION (54) (57) : The invention relates to the use of tissue specific transcription factor- nucleo some adducts or transcription cofactor-nucleosome adducts as biomark- ers in a biological fluid for the detection or diagnosis of a cancer in a subject. The in- vention further relates to using said tissue specific transcription factor or cofactor ad- ducts to identify the site of development of a cancer in a subject. = - _ =0,5 0,4 03 RI ca _ 0,0 0 0,2 = = _ = = — = = = = — = = Il ir) ir) IN ei ,-, IN ,-, © ei \"lay Healthy Breast Br , ?as - E-.-a , 57 lrin:r: Uro7hliat Control Cancer Cancer Cancer Bladder Carcinoma FIGURE 1 O WO 2017/162755 Al MIDEDIMOMMION1111111111111111111111111111111111110111111111110111111111111 Declarations under Rule 4.17: — before the expiration of the time limit for amending the — as to the applicant's entitlement to claim the priority the earlier application (Rule 4.17(iii)) of claims and amendments (Rule to be republished 48.2(h)) in the event of receipt of Published: — with international search report (Art. 21(3))