Patent SG-11201910152X-A (SG)
Title: Compositions for the treatment of drug-resistant tumors and methods of use thereof
Inventor: KANNAN RAGHURAMAN
IPC: A61K31/352
Filed: 2018-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT ill 1111u°11111OlDIIl °nolo HE mil o1 mo Ho mnio oimIE (10) International Publication Number WO 2018/183944 Al (51) International Patent Classification: A61K 31/138 (2006.01) A61K 31/352 A61K 31/15 (2006.01) A61K 31/353 A61K 31/277 (2006.01) A61K 31/423 (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2018/025544 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,931 31 March 2017 (31.03.2017) US (71) Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI [US/US]; 316 University Hall, Columbia, Missouri 65211 (US). (72) Inventors: KANNAN, Raghuram an; 316 University Hall, Columbia, Missouri 65211 (US). DHANANJAY, Suresh; 316 University Hall, Columbia, Missouri 65211 (US). MUKHERJEE, Soumavo; 316 University Hall, Colum- bia, Missouri 65211 (US). ZAMBRE, Ajit P.; 316 Univer- sity Hall, Columbia, Missouri 65211 (US). UPENDRAN, Anandhi; 316 University Hall, Columbia, Missouri 65211 (US). (74) Agent: HOLTZ, William A. et al.; Thompson Coburn LLP, One US Bank Plaza, St. Louis, Missouri 63101 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). W O 20 18/ 1839 44 Al (54) Title: COMPOSITIONS FOR THE TREATMENT OF DRUG-RESISTANT TUMORS AND METHODS OF USE THEREOF Cetedrnab_ AnsiRNA (57) : Provided herein are methods and compositions for sen- sitizing a cancer cell to a cancer treatment, for example to an anticancer drug by the inhibition of at least two cancer biomarkers. Further provid- ed are methods of treating and/or preventing a cancer including reducing the size of a tumor. Also provided are compositions comprising nanopar- tides associated with inhibitory molecules, such as siRNA, and/or anti- cancer drugs. Antibody targets EGFR for receptor mediated endocytosis Rar releasing drug Ow inhibits , Jegrades oncogene Figure 4 [Continued on next page] WO 2018/183944 Al MIDEDIMOMMIDIREEMOMOHNIMEHOHEMOVH Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))