Patent GB-432480-A (GB)
Title: Improvements in or relating to the manufacture of stabilised preparations
IPC: C07D215/40
Filed: 1933-12-21
Abstract: Stabilized aqueous solutions of aromatic amino-hydroxy, polyhydroxy, and polyamino compounds, basically substituted compounds of the quinoline and acridine series, and alkaloids are produced by the addition of a small quantity of an organic sulphydryl compound which may contain one or more sulphydryl groups and should be soluble in water.  For stabilizing solutions of aromatic aminohydroxy, polyamino and polyhydroxy compounds, aromatic sulphydryl compounds such as thiophenol and its derivatives or cystein and related compounds may be used, and thioglycollic acid and its derivatives may be used for stabilizing solutions of adrenalin, basically substituted quinoline and acridine compounds and alkaloids which are to be filled into ampoules.  In an example, 1,79 grams of 8-(a -diethylamino - d  - pentylamino) - 6 - methoxyquinoline (example 9 of Specification 267,169, [Class 2 (iii)]) is dissolved in normal hydrochloric acid and 60 grams of quinine hydrochloride and 90 grams of sarcosin anhydride are added and the mixture is diluted to 150 c.c.; 0,292 grams of thioglycollic acid and 11,7 c.c. of normal caustic soda are added and the solution is made up to 200 c.c.  The Specification as open to inspection under Sect. 91 includes the stabilization of aqueous solutions of oxidizable organic compounds in general and mentions pyrocatechin, resorcinol, hydroquinone, pyrogallol, the products obtained according to Specification 274,058, [Class 2 (iii)], basically-substituted heterocyclic compounds such as those described in Specification 267,169 (including basically - substituted amino - compounds, for instance of the thiazine and triphenyl methane series), quinidine, morphine, papaverine, hordenine, codeine, thebaine, ephedrin, hormones (including the female sex hormones), and vitamins.  Other stabilizers mentioned are thiocarboxylic acids, thiolactic acid, sulphydryl albumoses (obtainable by hydrolysis and reduction of keratin), thiophenol carboxylic and sulphonic acids and their salts.  These substances may assist in dissolving the bodies to be stabilized, and may be used in relatively small quantity such as below 3 per cent.  This subject-matter does not appear in the Specification as accepted.ALSO:Stabilized aqueous solutions of aromatic amino-hydroxy, polyhydroxy, and polyamino compounds, basically substituted compounds of the quinoline and acridine series, and alkaloids are produced by the addition of a small quantity of an organic sulphydryl compound which may contain one or more sulphydryl groups and should be soluble in water.  For stabilizing solutions or aromatic amino-hydroxy, polyamino and polyhydroxy compounds, aromatic sulphydryl compounds such as thiophenol and its derivatives or cyste<\>uin and related compounds may be used, and thioglycollic acid and its derivatives may be used for stabilizing solutions of adrenalin, basically substituted quinoline and acridine compounds and alkaloids which are to be filled into ampoules.  In an example 1,79 grams of 8- (a -diethylamino-d -penthylamino) -6-methoxyquinoline (Example 9 of Specification 267,169, [Class 2 (iii)], is dissolved in normal hydrochloric acid and 60 grams of quinine hydrochloride and 90 grams of sarcosin anhydride are added and the mixture is diluted to 150 c.c.; 0,292 grams of thioglycollic acid and 11,7 c.c. of normal caustic soda are added and the solution is made up to 200 c.c.  The Specification as open to inspection under Sect. 91 includes the stabilization of aqeuous solutions of oxidizable organic compounds in general and mentions pryocatechin, resorcinol, hydroquinone, pyrogallol, the products obtained according to Specification 274,058, [Class 2 (iii)], basically-substituted heterocyclic compounds such as those described in Specification 267,169 (including basically-substituted amino-compounds, for instance of the thiazine and triphenyl methane series) quinidine, morphine, papaverine, hordenine, codein thebain, ephedrin, hormones, (including the female sex hormones) and vitamins.  Other stabilizers mentioned are thiocarboxylic acids, thiolactic acid, sulphydryl albumoses (obtainable by hydrolysis and reduction of keratin), thiophenol carboxylic and sulphonic acids and their salts.  These substances may assist in dissolving the bodies to be stabilized, and may be used in relatively small quantity such as below 3 per cent.  This subject-matter does not appear in the Specification as accepted.