baber/WOPTO huggingface dataset:
Patent EP-3307884-A2 (EP)
Inventor: BEGEMANN MATTHEW
IPC: C12N9/22
Filed: 2017-02-15
Abstract: L'invention concerne des compositions et des procédés de modification de séquences d'ADN génomiques. Les procédés produisent des cassures double brin (DSB) au niveau de sites cibles prédéterminés dans une séquence d'ADN génomique, résultant en la mutation, l'insertion et/ou la délétion de séquences d'ADN au niveau du (des) site (s) cible (s) dans un génome. Les compositions comprennent des constructions d'ADN comprenant des séquences nucléotidiques qui codent pour une protéine Cpf1 ou Csm1 liée de manière fonctionnelle à un promoteur qui peut être utilisé dans les cellules d'intérêt. Les constructions d'ADN peuvent être utilisées pour diriger la modification de l'ADN génomique au niveau de loci génomiques prédéterminés. L'invention concerne également des procédés d'utilisation de ces constructions d'ADN pour modifier des séquences d'ADN génomiques. De plus, l'invention concerne des compositions et des procédés de modulation de l'expression de gènes. Les compositions comprennent des constructions d'ADN comprenant un promoteur qui peut être utilisé dans les cellules d'intérêt liées de manière fonctionnelle à des séquences nucléotidiques qui codent pour une protéine Cpf1 ou Csm1 mutée qui n'a plus la capacité de production de DSB, éventuellement liée à un domaine qui régule l'activité transcriptionnelle. Les procédés peuvent être utilisés pour réguler à la hausse ou à la baisse l'expression de gènes au niveau de loci génomiques prédéterminés. 89 CSR 38493285v1 Attorney Docket: B88552 1060WO (0057.1)
Patent EP-3405313-A2 (EP)
Title: Dispositif de coupe
Inventor: BOUCHIER JOHANNES
IPC: B26B3/08
Filed: 2017-01-19
Abstract: L'invention concerne un dispositif de coupe pouvant être actionné manuellement pour couper un matériau de feuille flexible, le dispositif de coupe comprenant un corps principal qui se déplace sur une surface de travail et un corps de guidage intégré pour mettre en prise par coulissement un bord latéral d'une surface de travail sur laquelle la feuille flexible coupée peut reposer, produisant une coupe droite. Le dispositif de coupe portatif tenu à la main et léger permet de couper du matériau de façon libre et indépendante d'autres outils de manière à ce que la longueur ou l'emplacement de la coupe et la quantité de matériau coupé à la fois ne soient pas limités par l'outil et de manière à ce que la surface de travail ne soit pas endommagée. Le dispositif de coupe est en outre relativement plus sûr en comparaison avec des outils de coupe classiques.
Patent EP-3541378-A2 (EP)
Inventor: LEE DANIEL CARL
IPC: A61K31/404
Filed: 2017-11-16
Abstract: Disclosed herein are compounds and methods for antagonizing GPRC6a for the treatment of proteinopathies.
Patent EP-3416047-A2 (EP)
Inventor: MOWER OLLIE
IPC: G06F9/52
Filed: 2018-06-15
Abstract: A method of synchronizing a group of scheduled tasks within a parallel processing unit into a known state is described. The method uses a synchronization instruction in a scheduled task which triggers, in response to decoding of the instruction, an instruction decoder to place the scheduled task into a non-active state and forward the decoded synchronization instruction to an atomic ALU for execution. When the atomic ALU executes the decoded synchronization instruction, the atomic ALU performs an operation and check on data assigned to the group ID of the scheduled task and if the check is passed, all scheduled tasks having the particular group ID are removed from the non-active state.
Patent EP-3406260-A2 (EP)
Inventor: SHARPLESS NORMAN E
IPC: A61K38/17
Filed: 2010-05-13
Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.
Patent EP-3431197-A2 (EP)
Title: Vorrichtung zur hydrodynamischen beseitigung von störstellen im inneren von rohrleitungen, insbesondere zur sanierung und reinigung von wasserführenden rohrleitungen im häuslichen, kommunalen und industriellen bereich
Inventor: HERM JÜRGEN
IPC: F28G1/16
Filed: 2018-07-20
Abstract: Die Erfindung betrifft eine Vorrichtung zur hydrodynamischen Beseitigung von Störstellen im Inneren von Rohrleitungen, insbesondere zur Sanierung und Reinigung von wasserführenden Rohrleitungen im häuslichen, kommunalen und industriellen Bereich. Dazu besitzt die Vorrichtung eine relativ zur Rohrleitung bewegbare Druckstrahldüse (2) mit mindestens einer Austrittsöffnung (24) zur Erzeugung eines Druckstrahls (25), an die zur Zufuhr einer unter Druck stehenden Arbeitsflüssigkeit mindestens ein Druckschlauch (5) angeschlossen ist. Darüber hinaus umfasst die Vorrichtung eine Vorschubeinrichtung (6) zur Bewegung und Positionierung der Druckstrahldüse (2) in der Rohrleitung. Zur Verbesserung der Handhabung und Wirkungsweise sowie zur Erweiterung des Einsatzbereiches der Vorrichtung wird erfindungsgemäß vorgeschlagen, dass zwischen Vorschubeinrichtung (6) und Druckstrahldüse (2) ein Tragelement (3) angeordnet ist, das über erste Anschlussmittel lösbar mit der Vorschubeinrichtung (6) verbunden ist und das über zweite Anschlussmittel lösbar mit der Druckstrahldüse (2) verbunden ist.
Patent EP-3570883-A2 (EP)
Inventor: SCHWARTZ-EISENBACH MICHAL
IPC: C07K16/28
Filed: 2018-01-17
Abstract: An active agent that causes an increase in the number of disease-associated microglia (DAM) for use in treating a neurodegenerative disease is provided.
Patent EP-3567608-A2 (EP)
Inventor: KIM HAN GON
IPC: G21C15/18
Filed: 2018-01-02
Abstract: The present invention relates to a nuclear power plant having improved cooling performance and a method for operating the same. The nuclear power plant having improved cooling performance according to the present invention includes: a reactor including a reactor core; a high temperature pipe and a low temperature pipe extending from the reactor; a mixed-type safety injection tank which contains cooling water, is connected to the low temperature pipe and the reactor, and is positioned higher than the reactor; a cooling water tank connected to the reactor and positioned higher than the reactor; and a pressure reducing valve connected to the high temperature pipe.
Patent EP-3480592-A2 (EP)
Inventor: KOO SANG HYUN
IPC: G01N29/04
Filed: 2018-01-30
Abstract: A non-destructive inspection judgment system for inspecting a non-destructive inspection subject using ultrasonic waves, including an ultrasonic wave generator transmitting and receiving ultrasonic signals by generating ultrasonic waves to the non-destructive inspection subject placed on an inspection table, an interface unit transmitting an ultrasonic signal received from the ultrasonic wave generator to an ultrasonic wave generation data controller, the ultrasonic wave generation data controller processing ultrasonic wave data received from the interface unit, a sealing defect presence judger determining, using the processed ultrasonic wave data, whether a sealing defect is present, and a display displaying a result of the judgment on a monitor to detect an unsealed portion of an aluminum pouch.
Patent EP-3687567-A2 (EP)
Title: Anti-adrenomedullin (adm) binder for use in therapy or prevention of symptoms of illness
Inventor: BERGMANN ANDREAS
IPC: C07K16/26
Filed: 2018-09-25
Abstract: Subject matter of the present invention is an anti-adrenomedullin (ADM) antibody or an anti- adrenomedullin antibody fragment or anti-ADM non-Ig scaffold for use in therapy or prevention of symptoms of illness and/or for use in therapy or prevention of diseases characterized by said symptoms. The symptoms of illness may be selected from the group of nausea, headache, muscle aches, back pain, shivering, vomiting in a subject wherein said antibody or fragment or scaffold may bind to ADM of amino acids 1 to 52 (SEQ ID NO: 1), or to fragments thereof.
Patent EP-3658942-A2 (EP)
Inventor: KARNER DON
IPC: G01R31/36
Filed: 2018-07-27
Abstract: The system may be configured to perform operations including measuring a temperature and a voltage of a battery at various times producing data points, wherein each data point comprises the temperature and voltage of the battery and a respective time that the temperature and voltage was measured; assigning each data point to a respective cell in a matrix stored on a, wherein the matrix comprises a first axis comprising voltage ranges and a second axis comprising temperature ranges, wherein each cell is associated with a voltage range and a temperature range, wherein the voltage and temperature of each data point is within the voltage range and temperature range, respectively, of the respective cell; and/or generating a first value in a counter comprised in each cell reflecting a total number of data points assigned to the cell, such that the first value in each cell is stored in the memory.
Patent EP-3528335-A2 (EP)
Inventor: HJORTESET JENS
IPC: H01M10/6563
Filed: 2019-02-19
Abstract: Marine energy storage unit with thermal runaway safety barriers to prevent cell temperature increase, said marine energy storage unit comprises at least one closed module cabinet (10) with a plurality of stacked battery cells (4) and an internal cooling system. The internal cooling system comprises an enclosed cabinet cooling circuit (3) with a water-to-air exchanger (20) for air cooling of the battery cells (4), and the water-to-air exchanger (20) is connected to a water-to-water heat exchanger (30) for receipt of water from an external source.
Patent EP-3588074-A2 (EP)
Inventor: KOPPERT KLAUS
IPC: G01N27/404
Filed: 2019-05-29
Abstract: Um ein Verfahren zur Reinigung, Konditionierung, Kalibration, Justage und Konditionierung eines amperometrischen Sensors einer Messeinrichtung zur Bestimmung eines Inhaltsstoffes in einem Elektrolyten mit einer durch eine selektiv durchlässige Membran verschlossenen, den Elektrolyten enthaltenden Messkammer, in der die Arbeitselektrode und eine mit der Arbeitselektrode elektrisch verbundene Referenzelektrode angeordnet ist, wobei die Membran für den zu bestimmenden Inhaltsstoff durchlässig ist, wobei die Bestimmung des Inhaltsstoffes während eines Messintervalls dadurch erfolgt, das eine Spannung zwischen Arbeitselektrode und Referenzelektrode angelegt wird, der Strom, der über die elektrische Verbindung von Arbeitselektrode und Referenzelektrode fließt, gemessen wird und aus dem gemessenen Strom auf den Inhaltsstoff rückgeschlossen wird, bereitzustellen, das eine vergleichbare oder sogar eine bessere Reinigungs- und Konditionierwirkung als die aus dem Stand der Technik bekannten Verfahren aufweist, für das jedoch ein einfacherer apparativer Aufbau ausreichend ist, wird ein Verfahren beschrieben, das dadurch gekennzeichnet ist, dass ein Konditioniermittel in der Messeinrichtung erzeugt wird, wobei als Konditioniermittel entweder ein Oxidationsmittel, welches an der Arbeitselektrode reduziert wird, oder ein Reduktionsmittel, welches an der Arbeitselektrode oxidiert wird, verwendet wird.
Patent EP-3728866-A2 (EP)
Inventor: HANNA IBRAHIM MOUNIR
IPC: F15B15/20
Filed: 2019-01-17
Abstract: Implementations are disclosed herein that relate to a cylinder occupying structure. An example provides a cylinder system comprising a mechanical cylinder including an internal space in which a fluid is introduced, and a piston configured for reciprocating motion in the internal space, and a cylinder occupying structure including an insertion rod acting as a second piston, wherein the insertion rod is variably inserted into, and retracted from, the internal space of the cylinder in correspondence with the reciprocating motion of the piston and where parts of the insertion rod and the piston may surround the combustion space.
Patent EP-3773875-A2 (EP)
Inventor: KRYZANSKI JAMES
IPC: A61N1/05
Filed: 2019-04-03
Abstract: Disclosed are devices, electrodes, systems, methods, and other implementations, including a device that includes an electrode comprising an elongated body, a plurality of electrode contacts disposed on a first side of the elongated body, and a cannulation channel defined along a longitudinal axis of the electrode. The device further includes a guiding mechanism received within the cannulation channel, the guiding mechanism configured to guide the electrode for placement at a target area inside a body of a patient. In some embodiments, the cannulation channel is configured to receive irrigation fluids dispensed through a perforated end located near a leading tip of the elongated body.
Patent EP-3744156-A2 (EP)
Inventor: REISS ALLAN
IPC: H05B37/02
Filed: 2019-01-18
Abstract: A system, apparatus and method for transmission of control data is provided. Application software executed on a smart phone or other computing device communicates with lighting fixtures or other configurable devices to automatically detect and pair with the devices without requiring a user to go through a pairing process. Additionally, the application software automatically places the devices in groups to coordinate the operation of those devices without requiring any complicated programming effort by a user. Further, the application software instructs each group of devices to provide a particular output or result, which may be different from group to group.
Patent EP-3864045-A2 (EP)
Inventor: ECKELMAN BRENDAN P
IPC: C07K16/28
Filed: 2019-10-09
Abstract: Provided herein are binding polypeptides that specifically bind DLL3. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific contructs and chimeric antigen receptors, that bind DLL3. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided DLL3 binding polypeptides for treating diseases and conditions, such as cancer.
Patent EP-3902961-A2 (EP)
Inventor: KIZICI AYKUT
IPC: E03D5/10
Filed: 2019-12-16
Abstract: The invention relates to a contaminant type detection system and method, which enable to detect the type of the contaminants contained by means of wireless signals, before or after the use, by the liquid within the component of the ceramic sanitary ware (1) that provides the connection of said ceramic sanitary ware (1) with the wastewater installation, in other words, within the elbow structure (2), and which, in case a contaminant other than the expected is encountered, enable to inform the user and/or third parties about said contaminant.
Patent EP-4021918-A2 (EP)
Inventor: Hemberger Jürgen
IPC: C07K14/435
Filed: 2019-08-26
Abstract: La présente invention concerne un peptide comprenant ou constitué d'une séquence de 5 à 25 résidus d'acides aminés, au moins 35 % desdits résidus d'acides aminés étant Pro.
Patent EP-3839817-A2 (EP)
Inventor: HUSAIN AMMAR
IPC: G06K9/00
Filed: 2020-12-18
Abstract: Implementations set forth herein relate to generating training data, such that each instance of training data includes a corresponding instance of vision data and drivability label(s) for the instance of vision data. A drivability label can be determined using first vision data from a first vision component that is connected to the robot. The drivability label(s) can be generated by processing the first vision data using geometric and/or heuristic methods. Second vision data can be generated using a second vision component of the robot, such as a camera that is connected to the robot. The drivability labels can be correlated to the second vision data and thereafter used to train one or more machine learning models. The trained models can be shared with a robot(s) in furtherance of enabling the robot(s) to determine drivability of areas captured in vision data, which is being collected in real-time using one or more vision components.
Patent EP-3851407-A2 (EP)
Inventor: IWAMOTO KUNIHIRO
IPC: B66F3/08
Filed: 2020-12-23
Abstract: To make it possible to freely move a moving body between level surfaces located at different heights that are not connected by a vertical member. A moving body (1) includes a movable moving part (2), an expansion/contraction part (3) disposed in the moving part (2) and configured to expand and contract in a vertical direction, a first engagement part (4) disposed at a tip of the expansion/contraction part (3) and configured to engage with a member located in a surrounding environment, and a control unit (5) configured to control the moving part (2) and the expansion/contraction part (3). The control unit (5) moves the moving part (2) to a target height position by engaging the first engagement part (4) with a member located at the target height position and then expanding or contracting the expansion/contraction part (3).
Patent EP-3946652-A2 (EP)
Inventor: GRIMES PAUL EARL
IPC: A63F1/02
Filed: 2020-04-03
Abstract: System having an RFID tag reader and a camera to map playing cards to RFID tag values. Each card is inserted into a sleeve that has an RFID tag. During or after insertion of card into sleeve, the camera captures an image of the card and the RFID reader captures an RFID tag value for the sleeve. The identity of the card is then determined from the captured image and mapped to the RFID tag value. This mapping information is generated for each card-sleeve pair in a card deck and utilized to track the movement of the cards during game play. The RFID tag value of each card-sleeve pair in the card deck is captured before and after a player draws a card from the deck. The missing RFID tag values are compared to the mapping information to identify which cards where drawn by the player.
Patent EP-3959350-A2 (EP)
Title: Gas distribution unit in connection with ald reactor
Inventor: MALILA MATTI
IPC: C23C16/44
Filed: 2020-04-24
Abstract: The invention relates to a gas distribution unit (10) in connection with an atomic layer deposition reactor. The gas distribution unit (10) comprises an inlet surface (14), an outlet surface (16), a process gas channel (20, 40) extending through the gas distribution unit (10) and being open to the inlet surface (14) and to the outlet surface (16), a barrier gas inlet fitting (26, 46, 30, 33) connected to the process gas channel (20, 40) between the inlet surface (14) and the outlet surface (16) for supplying barrier gas to the process gas channel (20, 40), and a barrier gas outlet fitting (28, 48, 34, 39) connected to the process gas channel (20, 40) between the inlet surface (14) and the barrier gas inlet fitting (26, 46, 30, 33) for discharging barrier gas from the process gas channel (20, 40).
Patent EP-3925549-A2 (EP)
Inventor: TENNENT THOMAS DUNCAN
IPC: A61B17/17
Filed: 2021-05-27
Abstract: Surgical constructs, assemblies and methods of tissue fixation are disclosed. An anterior glenoid guide is a cuboid block configured to be introduced via the rotator interval to lie on the anterior glenoid. The guide has an internal thread for a handle and two flanges which lie on the anterior glenoid. On the anterior face (opposite the neck of the glenoid), the guide is provided with two holes which are sized to receive a drill guide. The holes mate with slots such that the block can be removed after sutures and fixation devices are installed. The anterior glenoid guide can be an arthroscopic anterior glenoid graft guide.
Patent EP-4229077-A2 (EP)
Inventor: HUANG HAINING
IPC: C07K14/55
Filed: 2021-10-13
Abstract: This disclosure relates, inter alia to: modified interleukin 2 (IL-2) polypeptides; RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding such modified IL-2 polypeptides; methods of making such modified IL-2 polypeptides and RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding same; and methods of using such modified IL-2 polypeptides and RNA polynucleotides, DNA polynucleotides, non-viral vectors, and viral vectors encoding same.
Patent EP-4093610-A2 (EP)
Inventor: GANTZ JEREMY
IPC: A43B5/02
Filed: 2021-11-17
Abstract: The present disclosure provides for articles having structural color and methods of making articles having structural color. In an aspect, the present disclosure provides for articles that exhibit structural colors through the use of an optical unit. The optical unit, which is composed of at least two units, is disposed on a substrate (e.g., the surface of the article) and when exposed to visible light, the optical unit imparts a first structural color and a second structural to the article, where each structural color is visible color produced, at least in part, through optical effects.
Patent EP-4068339-A2 (EP)
Inventor: KIM SEHUN
IPC: H01L21/368
Filed: 2022-03-29
Abstract: A metal oxide composition includes: a solvent; a metal oxide; and a hydrogen cation source including a compound of Formula 1, a compound of Formula 2, or any combination thereof:
     
     
wherein, in Formulae 1 and 2, the variables are described herein.
Patent EP-4123770-A2 (EP)
Inventor: WALECZEK HENRYK
IPC: H01M8/2465
Filed: 2022-07-04
Abstract: Die Erfindung betrifft ein System zur Positionserkennung einer Vielzahl von Kontaktmodulen (10) zur Kontaktierung einer Vielzahl von zu Gruppen gruppierten Bipolarplatten eines Brennstoffzellensystems, wobei das System die Vielzahl von Kontaktmodulen (10), eine zentrale Steuereinheit (20) und zumindest eine Auswerteeinheit aufweist, wobei die Kontaktmodule (10) jeweils eine Spannungsmesseinrichtung (11) und einen Messwiderstand (12) aufweisen, die Steuereinheit (20) eine elektrische Energiequelle (21) mit einem Bezugspotential (22) aufweist, die Kontaktmodule (10) mit ihren Messwiederständen (12) entlang einer Messleitung (30) in Reihe mit der Energiequelle (21) geschalten sind und eine Reihe von miteinander elektrisch verbundenen Kontaktmodulen (10) bilden und die Spannungsmesseinrichtungen (11) jeweils ausgebildet sind, eine Potentialdifferenz zwischen der Messleitung (30) im Bereich des jeweiligen Kontaktmoduls (10) und dem Bezugspotential (22) zu ermitteln, welche zu der Position des jeweiligen Kontaktmoduls (10) in der Reihe von Kontaktmodulen (10) korreliert, und wobei die zumindest eine Auswerteeinheit ausgebildet ist, aus der von zumindest einer der Spannungsmesseinrichtungen (11) ermittelte Potentialdifferenz eine Position des jeweiligen Kontaktmoduls (10) in der Reihe zu bestimmen
Patent EP-4279583-A2 (EP)
Inventor: LITTLE MELISSA
IPC: C12N5/0735
Filed: 2015-12-15
Abstract: A method is provided for producing renal organoids comprising nephrons, ureteric bud and vasculature and/or progenitors of these. In one embodiment, the methods includes contacting intermediate mesoderm cells with: fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2 and optionally, one or more selected from the group consisting of: bone morphogenic protein 7; heparin; a Wnt agonist; retinoic acid; and an RA antagonist under conditions that promote formation of vascularized renal organoids. Another embodiment includes producing mesoderm cells by sequentially contacting pluripotent stem cells with a Wnt agonist and fibroblast growth factor 9 and/or fibroblast growth factor 20 and/or fibroblast growth factor 2, followed by a relatively short re-exposure to the Wnt agonist. The renal organoids may have end uses such as for kidney repair and regeneration, bioprinting of kidneys or functional components thereof, renal cell arrays and screening compounds for nephrotoxicity.