baber/WOPTO huggingface dataset:
Patent RU-2768045-C2 (RU)
Title: СПОСОБ ПОЛУЧЕНИЯ ЧАСТИЦ РЕКОМБИНАНТНОГО АДЕНОАССОЦИИРОВАННОГО ВИРУСНОГО ВЕКТОРА (rAAV)
Inventor: QU GUANG
IPC: C07K14/755
Filed: 2017-07-21
Granted: 2022-03-23
Abstract: Настоящее изобретение относится к способу получения частиц рекомбинантного аденоассоциированного вирусного вектора (rAAV) с высоким уровнем выделения или с высоким титром. Способ включает: сбор клеток и/или супернатанта культуры клеток, содержащих частицы вектора rAAV; необязательную их концентрацию; лизис; фильтрацию; подвергание полученного осветленного лизата ионообменной хроматографии на колонке и необязательно концентрацию полученного элюата; смешивание элюата с колонки или концентрированного элюата с колонки с хлоридом цезия и подвергание полученной смеси градиентному ультрацентрифугированию для отделения частиц полноценного вектора rAAV от частиц пустого капсида AAV и других связанных с вектором AAV примесей; сбор частиц полноценного вектора rAAV, отделенных на предыдущей стадии, и получение состава частиц полноценного вектора rAAV в буфере с неионным поверхностно-активным веществом; подвергание частиц полноценного вектора rAAV, полученных на предыдущей стадии, обмену буфера посредством проточной фильтрации вдоль потока с последующей фильтрацией. Осуществление изобретения обеспечивает улучшение извлечения и/или повышение титра частиц полноценного вектора rAAV после проведения процесса очистки. 51 з.п. ф-лы, 5 ил., 3 пр.
Patent RU-2735635-C2 (RU)
Title: Улучшения планирования для систем беспроводной связи ограниченной латентности и высокой надежности
Inventor: HOLFELD BERND
IPC: H04W72/04
Filed: 2017-08-11
Granted: 2020-11-05
Abstract: Изобретение относится к устройству для системы беспроводной связи, причем устройство выполнено с возможностью осуществления полупостоянного планирования (SPS), причем размер интервала SPS базируется на одном или более интервалах времени передачи (TTI). Технический результат заключается в улучшении полупостоянного планирования в системе беспроводной связи. Устройство выполнено с возможностью приема и обработки сообщения конфигурации, причем сообщение конфигурации включает в себя одно или более полей данных, указывающих размер интервала SPS, причем сообщение конфигурации косвенно сигнализирует размер интервала SPS с использованием одного или более кодовых слов, причем каждое кодовое слово представляет определенный размер интервала SPS, причем устройство включает в себя хранилище, выполненное с возможностью хранения множества элементов, причем в каждом элементе содержится несколько интервалов времени передачи, задающих размер интервала SPS, и при этом устройство выполнено с возможностью осуществления доступа к хранилищу с использованием кодового слова, и получения размера интервала SPS из хранилища. 4 н. и 16 з.п. ф-лы, 26 ил.
Patent RU-2760405-C2 (RU)
Inventor: DANKEN MAJKL
IPC: A61N1/36
Filed: 2017-11-06
Granted: 2021-11-24
Abstract: Группа изобретений относится к медицине, а именно к терапевтическим устройствам для тренировки мышц. Устройство содержит основание для тренировки на велотренажере, контроллер функциональной электростимуляции и автоматическую систему регулирования спазма. Основание велотренажера содержит первую опору для конечностей и вторую опору для конечностей. Опоры выполнены с возможностью приведения в движение или противодействия движению двигателем. Контроллер выполнен с возможностью управления двигателем. Система регулирования спазма содержит монитор, сконфигурированный с возможностью непрерывного мониторинга крутящего момента, необходимого для вращения одной или обеих из указанных опор для конечностей. Система регулирования спазма сконфигурирована с возможностью вычисления скорости изменения указанного крутящего момента, максимальной частоты вращения кривошипа, максимальной скорости разгона кривошипа и максимальной скорости разгона, максимальной электрической стимуляции и максимальной скорости нарастания стимуляции. Система регулирования спазма сконфигурирована с возможностью идентификации возможного начала спазма при превышении контролируемой величины крутящего момента или скорости изменения крутящего момента в отношении предварительно заданного значения. Система регулирования спазма сконфигурирована с возможностью сравнения, по меньшей мере, текущей частоты вращения кривошипа с указанной вычисленной максимальной скоростью кривошипа и текущего уровня электростимуляции с указанной вычисленной максимальной стимуляцией. Достигается возможность регулировать уровни темпа и стимуляции для спазма и миотатического рефлекса. 3 н. и 9 з.п. ф-лы, 1 ил.
Patent RU-2750124-C2 (RU)
Title: Системы и способы ручного стрелкового оружия с переводчиком огня
Inventor: SULLIVAN LEROY JAMES
IPC: F41A17/46
Filed: 2017-09-20
Granted: 2021-06-22
Abstract: Ручное стрелковое оружие с переводчиком огня, имеющее режим автоматического огня с открытого затвора и полуавтоматического огня с закрытого затвора, содержит спусковой механизм с подпоркой спускового крючка, обеспечивающей, когда отпускают спусковой крючок в режиме автоматического огня с открытого затвора, остановку затворной рамы в положении с открытым затвором, удерживаемой шепталом стрельбы с открытого затвора. Подпорка спускового крючка может включать в себя опору, которая следом за первым нажатием на спусковой крючок в режиме автоматического огня с открытого затвора, скользит под задний конец спускового крючка и подпирает его в положении, которое обеспечивает захват шепталом стрельбы с открытого затвора затворной рамы, когда спусковой крючок отпускают и происходит его подпирание, но предотвращает зацепление ударника шепталом спуска. Технический результат - исключение преждевременного выстрела вследствие досылания патрона в нагретый ствол после ведения автоматического огня. 14 н. и 27 з.п. ф-лы, 29 ил.
Patent RU-2757996-C2 (RU)
Title: New therapeutic application of h3-ligands
Inventor: LECOMTE JEANNE-MARIE
IPC: A61P25/16
Filed: 2018-03-21
Granted: 2021-10-25
Abstract: FIELD: medicine. 
     SUBSTANCE: invention relates to the application of (3S)-4-{4-[3-(3-methylpiperidine-1-yl)propoxy]phenyl}pyridine 1-oxide or its pharmaceutically acceptable salt and/or solvate of the specified compound (A) or its salt for the treatment and/or prevention in humans of diseases selected from the following: Alzheimer's disease; attention disorder; insomnia and memory impairment; cognitive disorders in psychiatric pathologies; cognitive disorders, mood disorders and concentration disorders, especially in elderly patients; depressive or asthenic conditions; Parkinson's disease; obstructive sleep apnea syndrome; dementia with Lewy bodies; vascular dementia; dizziness; motion sickness; obesity; diabetes and metabolic syndrome; sleep disorders; stress; psychotropic disorders; epilepsy; depression; narcolepsy with or without cataplexy; disorders of hypothalamic-pituitary secretion, cerebral circulation and/or in the immune system; excessive daytime sleepiness, such as excessive daytime sleepiness and fatigue associated with Parkinson's disease, obstructive sleep apnea syndrome or dementia; and/or for facilitation of night work or for adaptation to a change of a time zone in healthy people; substance abuse, in particular alcohol abuse; prevention of withdrawal syndrome with substance abuse; attention disorders; post-stroke fatigue, mood disorders, concentration and cognitive disorders; cognitive disorders in autism; chronic pain and chronic fatigue; attention and concentration disorders in ADHD (attention deficit hyperactivity disorder) in adults or after a stroke, where the specified use includes the administration of the compound (A) or its pharmaceutically acceptable salts, and/or solvates of the specified salts or the specified compound (A) to an adult, with a dosage of a free base between 20 and 50 mcg per day (in terms of the compound (A) in the form of the free base). 
     EFFECT: new therapeutic application of H3-ligands. 
     12 cl, 38 ex, 2 tbl
Patent RU-2769262-C2 (RU)
Inventor: PETTS METYU
IPC: C10L10/04
Filed: 2018-03-28
Granted: 2022-03-29
Abstract: FIELD: fuel industry. 
     SUBSTANCE: invention relates to additives in diesel fuel composition. Disclosed is a diesel fuel composition comprising an ester compound as an additive, which is a reaction product of a polybasic alcohol having the formula H-(OR)n-OH, and at least 1.5 molar equivalents of an unsubstituted or hydrocarbyl-substituted polycarboxylic acid or an anhydride thereof, where R is an unsubstituted alkylene group or one or more saccharide units, and n is at least 1; wherein the diesel fuel composition contains less than 50 wt. parts per million of sulfur. Also disclosed is a method of controlling deposits and use of an ester compound as a detergent additive. 
     EFFECT: reduction or prevention of formation of deposits in diesel engine. 
     20 cl, 1 dwg, 7 ex, 11 tbl
Patent UA-64801-C2 (UA)
Title: Composition possessing antiseptic, reparative and analgesic activities
Inventor: RUDKO ADOLINA PETRIVNA
IPC: A61P31/00
Filed: 2001-03-20
Abstract: The invention relates to the medicine and the veterinary, in particular to the composition possessing the antiseptic, reparative and analgesic activities. The composition comprises Miramystin, D-Pantenol (calcium pantotenate), Trimecain, and the hydrophilic base. The composition may be used for treating and preventing the purulent complications of the wounds developed upon the burns, the injury, and the surgery, the neurepathic eschar, and the decubitus.
Patent UA-48715-C2 (UA)
Title: Self-cleaning filter
Inventor: BONDARENKO VASYL PARFENIOVYCH
IPC: B01D35/22
Filed: 2001-11-19
Abstract: A self-cleaning filter contains a cylindrical case, disposed in the case with a round gap a filter-element, an inlet, an outlet, and a drain tubes, an ejector and a circulation pipeline, one end of which is connected to a cavity of lowered pressure for the ejector, and another is connected to the drain tube. The drain tube is made as a connecting and discharge tube and a settler chamber disposed between them, to the upper part of the chamber case the circulation pipeline and the connection tube are connected, and to the lower part - the discharge tube.
Patent UA-54073-C2 (UA)
Title: Convector ring
Inventor: BOCHAROV VITALII FEDOROVYCH
IPC: C21D9/54
Filed: 2002-04-30
Abstract: The invention relates to the field of metallurgy, in particular to the thermal treatment of cold-rolled coils in bell-type furnaces. A convector ring of bell-type furnace contains bearing base and supporting elements. Supporting elements are movably fixed to the bearing base due to welding thereof on movable fragments, preliminarily cut from the body thereof. The invention promotes to removal of temperature stresses in the ring body, increasing the heat exchange, prevents mashing and welding edges of cold-rolled coils.
Patent UA-75584-C2 (UA)
Title: Process for preparation of pregabalin and intermediate compounds, intermediate compounds
IPC: C07C227/10
Filed: 2001-11-01
Abstract: This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
Patent UA-57687-C2 (UA)
Title: Method for producing porcine insulin substance of high purity
Inventor: LAZAREV OLEKSII PAVLOVYCH
IPC: A61K38/28
Filed: 2003-01-03
Abstract: The method for producing the porcine insulin substance of high purity comprises the aqueous and alcohol extraction of the porcine pancreas followed by the concentration and the isolation of insulin substance from the extract. Then the substance is purified chromatographically with the aim of discarding proinsulin, the foreign proteins, and the insulin-related impurities. The product is crystallized. The porcine insulin substance is subjected to the reversed-phase chromatography on the silica gels C8 or C18. With the aim of purifying the substance from proinsulin and the foreign proteins, the elution is performed employing aqueous-organic solution with pH not exceeding 3.5 comprising 12-21% of isopropanol or propanol (preferably 18-20%) and no more than 0.25 M sodium acetate, ammonia acetate, ammonia sulfate, or sodium sulfate (preferably 0.01-0.06 M). The substance is purified from the insulin-related impurities employing isocratic mode of elution or the gradient of the organic modifier.
Patent UA-64488-C2 (UA)
Title: Method to increase safety at coal extraction in dangerous by methane workings and complex of means for its implementation
Inventor: SYDIAK VOLODYMYR OLEKSANDROVYC
IPC: E21C35/24
Filed: 2003-06-10
Abstract: Method to increase safety at coal extraction in dangerous by methane workings relates to mining and is in control of concentration of methane in atmosphere of extraction working by length of extraction working in several points. It can be used for prediction of explosion safety of mine atmosphere along line of working. One determines rate of concentration and time in which it can come to dangerous values in each of control points, and gives notification signal. Complex of means for implementation of method has block of integrated evaluation of danger by measured parameters, block for calculation of value of predicted value being measured and drawing histograms for each cycle of indicator interrogation. Continuous analysis of change of parameters of atmosphere is provided and operative notification on pre-emergency situation coming to existence.
Patent UA-71148-C2 (UA)
Title: Borehole charge
Inventor: BRYHINETS YURII VOLODYMYROVYCH
IPC: F42D1/00
Filed: 2003-10-22
Abstract: This invention relates to mining industry. A borehole charge comprises explosive substance placed to the well, axial cavity formed in the explosive substance, intermediate detonator. In the length of the borehole charge in turns charges of explosive substance are formed, with axial cavity and continuous ones, at that the length of the charge with axial cavity is not less than 1/3 of the length of the next continuous charge. This invention makes it possible to increase effectiveness of destructive effect of the borehole charge.
Patent UA-82079-C2 (UA)
Title: Flat commutator (variants)
Inventor: POTOCHNIC JOZE
IPC: H01R39/00
Filed: 2004-10-24
Abstract: The invention relates to a flat commutator comprising a bearing body (1), a plurality of conductor segments (3) in addition to an equivalent number of carbon segments (4) which are connected in an electrically conductive manner to the conductor segments in a positive fit Each carbon segment (4) comprises an annular projection (13) which is disposed opposite the face of the commutator (5), the front surface (15) of said annular projection being in contact with a corresponding annular contact surface (16) of the associated conductor segment (3) 1 he annular shaped contact surfaces (16) are respectively surrounded by a contact ring (24) of the related conductor segment (3) which is in contact, in gap free manner, with the associated annular shaped projection (13) A contact pin (17) projects into each conductor segment, said contact pin engaging, in a gap-free manner, with the corresponding bore (14) of the associated annular shaped projection (13) of the related carbon segment (4) The carbon segments are also respectively connected in an electrically conductive manner to the conductor segments (3) by means of the outer peripheral surface of the annular shaped front surface (15) and to the inner peripheral surface of the annular shaped protection (13).
Patent UA-82490-C2 (UA)
Title: Device for manufacture of multilayer bellows
Inventor: TALALAIEV SEMEN MYKOLAIOVYCH
IPC: B21D15/00
Filed: 2005-04-14
Abstract: A device for manufacture of multilayer bellows contains sleeves and plugs installed coaxially with possibility of axial displacement, a connecting pipe for supply of working fluid located on one of the sleeves, and an element, which forms corrugations. The containers are telescopically connected together by free edges, side surface, at least, one of sleeves is equipped with openings, and forming corrugations element is made in the form of elastic cylinder located on external surface of sleeves.
Patent UA-85498-C2 (UA)
Title: Disposable food packet (embodiments)
Inventor: SUKHONOS YURII ANATOLIIOVYCH
IPC: B65D81/00
Filed: 2005-12-23
Abstract: The invention concerns the means of packing of food products, i.e., disposable packets, in which food products are welded directly in the packing, and at joint storage lose their organoleptic and gustatory properties. A food disposable packet is a packet from filter paper, which contains, at least, two chambers, which have external and internal counter walls, packet has common lower edge, and its upper edges are fastened between them, a label-separator from moistureproof material located between counter internal chamber walls of packet is fastened to the packet and has an extension. The label-separator from moistureproof material has an extension from the side of the lateral edge of packet; this extension is located along one external wall of at least one chamber and is fastened to this one external wall with possibility of opening at least this one chamber. The embodiments of multichamber disposable packet from the filter paper, which are given in the claims, provide for new functional properties, improvement of the quality of beverage and convenience of packet use.
Patent UA-87114-C2 (UA)
Title: Process for preparation of extraction of ivy leaves, extraction, use thereof and drug
Inventor: RUNKEL FRANK
IPC: A61P11/00
Filed: 2004-09-10
Abstract: The invention relates to pharmacy and concerns A method for obtaining of ivy leaves extract with regulated content of С hederacozide and regulated content of-hederine. The invention also relates to the extract thus obtained, use thereof for preparation of a drug, and a drug.
Patent UA-80380-C2 (UA)
Title: Method for production of frozen casting patterns
Inventor: SHYNSKYI OLEH YOSYPOVYCH
IPC: B22C7/00
Filed: 2006-09-27
Abstract: The invention relates to foundry and concerns the production of frozen casting patterns. A method includes pouring of aqueous composition into the mold and freezing by immersing the mold into the liquid coolant. The duration of freezing and/or thickness of the frozen layer is determined by the value of expansion of aqueous composition during freezing or by the value of pressure increase, which is created at expansion of aqueous composition. The control of thickness of the frozen layer and/or duration of contact with the rig will ensure the required quality of patterns.
Patent UA-97368-C2 (UA)
Title: Steel composition with high conditions of high-temperature corrosion by oxidizing environments (variants) and its use, seamless pipe or armature is formed of this steel
Inventor: PETELO DANIEL
IPC: C22C38/22
Filed: 2007-06-07
Abstract: The invention concerns steels having excellent resistance over time, in a corrosive atmosphere due to oxidizing environments such as, for example, fumes or water vapour, under high pressure and/or temperature. The invention concerns a steel composition for special applications, said composition containing, by weight, about 1.8 to 11 % of chromium (and preferably between about 2.3 and 10 % of chromium), less than 1 % of silicon, and between 0.20 and 0.45 % of manganese. It has been found that it is possible to adjust the contents of the composition based on a predetermined model, selected to obtain substantially optimal properties with respect to corrosion in specific conditions of high temperature performances. Said model can involve as additive of as residue at least one element selected among molybdenum, tungsten, cobalt, and nickel.
Patent UA-94298-C2 (UA)
Title: Filtering device for cooling water of tubular turbine condenser
Inventor: KHARAKHASH OLEKSII KUZMYCH
IPC: B01D35/02
Filed: 2009-06-30
Abstract: The invention relates to cooling systems of large thermal power and nuclear power plants with condensing turbines. A filtering device for cooling water of tubular condenser of turbine contains a housing fastened between input and output pipes, inside the housing on an axle a filtering grate, washing and discharging pipes are installed with possibility of rotation. The housing is equipped with a detachable flange, the grate forms a hollow body opened from the side of input pipe with covering surface with cells for cooling water flow. The cells are extended towards cooling water flow and in direction of washing water flow, the grate surface is fastened on the axle by streamlined pylons, and the axle by one end in installed in a suspended bearing fastened to the housing by the streamlined pylons, the second axle end through a gasket, the detachable flange and bearing is put out of the housing with possibility of connecting the drive of rotation, at that largest size of the grate cell is less than smallest size of an opening of condenser tube, and total open area of the grate cells is more than area of the input pipe section, area of the output pipe section is more than area of the input pipe section, the least outer diameter of the detachable flange is more than largest grate diameter, at that the washing pipe is made in the form of a streamlined collector with slit openings in such a manner that the slit is adjacent to the grate surface and directed towards the grate cells, the discharge pipe is located lower than the washing pipe level and is equipped with spaced outlets. The invention provides for increasing energy supply stability, reliability and efficiency in the process of continuous operation of the condensation steam aggregate.
Patent UA-102510-C2 (UA)
Title: Method for the treatment of a material flow
Inventor: KOSCHUH WERNER
IPC: C12M1/12
Filed: 2007-12-19
Abstract: The invention relates to a method for the treatment of a material flow comprising at least one valuable substance of each of the following groups (A) amino acids, (B) carboxylic acids differing from amino acids, having 1 to 5 carbon atoms, and (C) inorganic salts, the method comprising the following steps: (1) treating the material flow by means of nanofiltration in order to obtain a retentate enriched with a valuable substance(A), (2) treating the permeate of step (1) by means of electrodialysis in order to obtain a concentrate enriched with a valuable substance (C), (3) treating the diluate of step (2) by means of a system (3) of two steps (4) and (5) interconnected either directly or indirectly, wherein (4) a treatment is carried out by means of reverse osmosis, and (5) a treatment is carried out by means of electrodialysis, wherein a concentrate enriched with a valuable substance (B) is obtained, (6) at least part of the retentate of step (4) is: fed to step (5) either directly or indirectly, and (7) at least part of the diluate of step (5) is fed to step (4) either directly or indirectly.