Patent SG-11201811329U-A (SG)
Title: Spheroids including biologically-relevant materials and related methods
Inventor: WILLIAMS STUART K
IPC: A61L27/24
Filed: 2017-06-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11011110111010101111101 110100111101111110011101110 111111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/005477 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: search Foundation, Inc., 300 East Market Street, Suite 300, A61L 27/52 (2006.01) C08J 3/24 (2006.01) Louisville, Kentucky 40202 (US). A61L 27/54 (2006.01) A61K 35/12 (2015.01) (74) Agent: WRIGHT, Terry L. et al.; c/o Stites & Harbi- A61L 27/56 (2006.01) A61K 35/39 (2015.01) A61L 27/24 (2006.01) C12N 5/0735 (2010.01) son, PLLC, 400 West Market Street, Suite 1800, Louisville, Kentucky 40202 (US). (21) International Application Number: PCT/US2017/039483 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 27 June 2017 (27.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/354,929 27 June 2016 (27.06.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/422,694 16 November 2016 (16.11.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: UNIVERSITY OF LOUISVILLE (84) Designated States (unless otherwise indicated, for every RESEARCH FOUNDATION, INC. [US/US]; 300 East kind of regional protection available): ARIPO (BW, GH, Market Street, Suite 300, Louisville, Kentucky 40202-1959 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventors: WILLIAMS, Stuart K.; c/o University of TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Louisville Research Foundation, Inc., 300 East Market EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Street, Suite 300, Louisville, Kentucky 40202 (US). GET- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (72) = — TLER, Brian C.; c/o University of Louisville Research TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Foundation, Inc., 300 East Market Street, Suite 300, KM, ML, MR, NE, SN, TD, TG). = Louisville, Kentucky 40202 (US). ZAKHARI, Joseph S.; c/o University of Louisville Research Foundation, Inc., 300 = East Market Street, Suite 300, Louisville, Kentucky 40202 _= = (US). GANDHI, Piyani S.; c/o University of Louisville Re- = Title: SPHEROIDS INCLUDING BIOLOGICALLY-RELEVANT MATERIALS AND RELATED METHODS = (54) = = Spheroid = = = = Pluronic = = Super Hydrophobic .4 \ , S U rf ac e IN IN 7r k r) FIG. ID 0 0 . a ' — c . (57) : A method of making a spheroid is provided that includes the step of providing a suspension having one or more bio- logically-relevant materials dispersed within a biocompatible medium. An amount of a hydrophilic material is deposited on a defined 0 area of a super-hydrophobic surface, and a droplet of the suspension is bioprinted onto the hydrophilic material positioned on the su- ei per-hydrophobic to thereby create the spheroid. [Continued on next page] WO 2018/005477 Al OII Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the earlier application (Rule 4.17(iii)) priority of the Published: — with international search report (Art. 21(3))