Patent GB-600834-A (GB)
Title: Improvements in or relating to the manufacture of materials resistant to or active against micro-organisms
IPC: A01N39/00
Filed: 1945-05-03
Abstract: Materials liable to microbiological decomposition, e.g. food and pharmaceutical preparations, are preserved by incorporating therein a compound having the general formula:-  <FORM:0600834/VI/1> in which R1, R2, R3 and R4 may be the same or different and represent hydrogen, alkyl, alkylene, halogen, acylamino, acyl, aryl, alkylamino, arylamino, alkylcarbonyl or arylcarbonyl, in which X represents (CH2)n where n is an integer, and in which at least one of the above mentioned substituents or hydroxy, aryloxy or alkoxy may be present on one or more of the carbon atoms represented by X; or alternatively, in which at least one of R1, R2, R3 and R4 may be the same or different and represent the above mentioned substituents other than hydrogen (the remainder, if any, being hydrogen) and X is a simple linkage.  In the above definitions the terms "alkyl" and "aryl" include such groups containing halogen, alkoxy, or acyloxy groups as substituents.  Antiseptic preparations comprise the above defined compounds admixed with a solvent, emulsifying agent, substratum or base.  Specified compounds are b -phenoxy-phenylethyl alcohol, b -phenoxy-n-propyl alcohol, b -phenoxy-tetramethyl ethanol, b -phenoxy-a (p-chlorophenyl) ethyl alcohol, g -phenoxy-n-propyl alcohol, b , g ,-diphenoxy-propyl alcohol, b -phenoxy-b  vinyl ethyl alcohol, b -phenoxy isopropyl alcohol, b  phenoxy-a  chloro-n-propyl alcohol, b  phenoxy-a  acetyl-n-propyl alcohol, d -phenoxy-n-butyl alcohol, b -phenoxy-b 1 (4-hydroxybenzoyl - oxy) - isopropyl alcohol, d -phenoxy-g -acelylamino-b  hydroxy-n-butyl alcohol, b -phenoxy-isopropyl alcohol, b -phenoxy-b 1-chloro-isopropyl alcohol, glyceryl monophenyl ether, and of b -phenoxy-b 1-methoxy-isopropyl alcohol. According to examples, (1) a disinfectant ointment is prepared by p  mixing the monophenyl ether of a -propylene glycol with glycerol or propylene glycol and emulsifying this mixture with water and glycerol mono-stearate or propylene glycol mono-stearate; (2) a disinfectant jelly is prepared by stirring a mixture of tragacanth, glycerol, and monophenyl-ether of propylene glycol or phenoxy-n-propyl alcohol into water; (3) g -chloro-b -hydroxy-a phenoxypropane is mixed with glucose - containing gelatine; (4) the monophenyl ether of propylene glycol and g -phenoxy-n-propyl alcohol is mixed with starch paste; (5) a disinfecting solution is prepared by dissolving a mixture of the monophenyl ether or propylene glycol and the monophenyl ether of glycerol in water; (6) a solution of b -phenoxy-b 1-methoxy-isopropyl alcohol in sterile water is used to sterilise catgut; (7) a solution of the monophenyl ether of propylene glycol is used in the manufacture of photographic gelatine; (8) a foot dusting powder comprises the monophenyl ether of glycol, zinc oxide, wheat starch and talc; (9) a hair wash comprises the monophenyl ether of propylene glycol, alcohol, propylene glycol, castor oil and water.  Specifications 350,379 and 409,971 are referred to.  The Provisional Specification describes also the use of compounds as above defined in which the benzene nucleus is replaced by the naphthalene nucleus.