Patent SG-11201901399Y-A (SG)
Title: Cmet monoclonal binding agents, drug conjugates thereof and uses thereof
Inventor: CORONELLA JULIA
IPC: C07K16/28
Filed: 2017-09-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI 0I0 11111 01 10001101 1101 010 1110 1101 011 MEV OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/062402 Al 05 April 2018 (05.04.2018) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07K 16/28 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/JP2017/035259 KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 28 September 2017 (28.09.2017) — with international search report (Art. 21(3)) (25) Filing Language: — with English sequence listing part of description (Rule 5.2(a)) (26) Publication Language: English (30) Priority Data: 62/401428 29 September 2016 (29.09.2016) US (71) Applicant: MITSUBISHI TANABE PHARMA COR- PORATION [JP/JP]; 3-2-10, Dosho-machi, Chuo-ku, Os- aka-shi, Osaka, 5418505 (JP). (72) Inventors: CORONELLA, Julia; c/o Tanabe Research Laboratories U.S.A., Inc., 4540, Towne Centre Court, San Diego, California, 92121 (US). BLOT, Vincent; c/o Tanabe Research Laboratories U.S.A., Inc., 4540, Towne Centre Court, San Diego, California, 92121 (US). GYMNOPOULOS, Marco; c/o Tanabe Research Labora- tories U.S.A., Inc., 4540, Towne Centre Court, San Diego, California, 92121 (US). TIMMER, Anjuli; c/o Tanabe Research Laboratories U.S.A., Inc., 4540, Towne Centre = Court, San Diego, California, 92121 (US). FUJITA, Ryo; c/o Mitsubishi Tanabe Pharma Corporation, 3-2-10, Dosho- machi, Chuo-ku, Osaka-shi, Osaka, 5418505 (JP). NEW- MAN, Roland; c/o Tanabe Research Laboratories U.S.A., Inc., 4540, Towne Centre Court, San Diego, California, 92121 (US). (74) Agent: SAMEJIMA, Mutsumi et al.; AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, Kakuda-cho, Kita-ku, Osaka-shi, Osaka, 5300017 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 (84) Designated States (unless otherwise indicated, for every N kind 0 ll• ei of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 0 --.... 00 1-1 (54) 0 Title: CMET MONOCLONAL BINDING AGENTS, DRUG CONJUGATES THEREOF AND USES THEREOF ei (57) : Presented herein, in certain embodiments, are compositions comprising monoclonal binding agents that specifically O bind to the extracellular domain of cMET and uses thereof.