Patent AU-2013201455-B2 (AU)
Title: Benzoheterocyclic compounds and use thereof
Inventor: TIAN HONGGI
IPC: A61K31/00
Filed: 2013-01-16
Granted: 2015-07-23
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/107283 Al 25 July 2013 (25.07.2013) W I PO I P CT (51) International Patent Classification: Tianjin 300457 (CN). CHENG, Ying; N1701, #220 C07D 263/54 (2006.01) A 61K 31/425 (2006.01) Dongting Road, Tianjin Economic-Technology Develop C07D 231/54 (2006.01) A61K31/41 (2006.01) ment Area, Tianjin 300457 (CN). HUANG, Gongchao; C07D 277/62 (2006.01) A61K31/42 (2006.01) N1701, #220 Dongting Road, Tianjin Economic-Techno C07D 285/14 (2006.01) A61P 35/00 (2006.01) logy Development Area, Tianjin 300457 (CN). C07D 209/02 (2006.01) A61P 29/00 (2006.01) (74) Agent: PEKSUNG INTELLECTUAL PROPERTY A6JK 31/433 (2006.01) LTD.; 908 Shining Tower, 35 Xueyuan Road, Haidian (21) International Application Number: District, Beijing 100191 (CN). PCT/CN2013/000037 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 16 January 2013 (16.01.2013) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (30) Priority Data: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 201210014021.X 17 January 2012 (17.01.2012) CN NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, 201210189086.8 8 June 2012 (08.06.2012) CN RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, 201210190520.4 8 June 2012 (08.06.2012) CN TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 201210189087.2 8 June 2012 (08.06.2012) CN ZM, ZW. (71) Applicant: TIANJIN BINJIANG PHARMA, INC. (84) Designated States (unless otherwise indicated, for every [CN/CN]; N1701, #220 Dongting Road, Tianjin Econom- kind of regional protection available): ARIPO (BW, GH, ic-Technology Development Area, Tianjin 300457 (CN). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (72) Inventors: TIAN, Hongqi; N1701, #220 Dongting Road, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Tianjin Economic-Technology Development Area, Tianjin TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 300457 (CN). JI, Conghui; N1701, #220 Dongting Road, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Tianjin Economic-Technology Development Area, Tianjin MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 300457 (CN). LIU, Chunlei; N1701, #220 Dongting TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Road, Tianjin Economic-Technology Development Area, ML, MR, NE, SN, TD, TG). Tianjin 300457 (CN). KONG, Li; N1701, #220 Dongting Road, Tianjin Economic-Technology Development Area, [Continued on next page] (54) Title: BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF x 2 R _ R XtN R2) (57) Abstract: Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R1, R2 , R3 , R4 , R', R6, X1 and X2 is as defined in the description. These compounds are protein kinases inhibitors, especially the inhibit N ors of Mek, which are useful in the treatment of cancers and inflammation of mammals. Disclosed are the treatment methods of can cers and inflammation of mammals as well as pharmaceutical compositions comprising the compounds described herein. The prepar ation of benzoheterocyclic compounds are disclosed. Disclosed are the preparation of potential drug candidates, such as ben zooxazol, benzothiazol, benzothiadiazol and the like. W O 2013/107283 A1lII|III|lllllIllll||||I||||I||||||I||D|D|II |||||||||||||||I|I|||||||||I| Published: - with international search report (Art. 21(3))