Patent AU-2012327206-B2 (AU)
Title: Humanized IL-6 and IL-6 receptor
Inventor: WANG LI-HSIEN
IPC: C07K14/715
Filed: 2012-10-29
Granted: 2015-05-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/063556 Al 2 May 2013 (02.05.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K14/54 (2006.01) A01K 67/027 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K14/715 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, ) .a BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, PCT/US2012/062379 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 29 October 2012 (29.10.2012) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/552,900 28 October 2011 (28.10.2011) US (84) Designated States (unless otherwise indicated, for every 61/556,579 7 November 2011 (07.11.2011) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (71) Applicant: REGENERON PHARMACEUTICALS, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, INC. [US/US]; 777 Old Saw Mills River Road, Tarrytown, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, NY 10591 (US). EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors: WANG, Li-hsien; 184 Brianwood Drive, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Somers, NY 10589 (US). DORE, Anthony, T.; 485 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Gramatan Avenue, Mount Vernon, NY 10552 (US). ML, MR, NE, SN, TD, TG). STEVENS, Sean; 355 Berry Street, #413, San Francisco, Published: CA 94158 (US). MURPHY, Andrew, J.; 10 Newton _ with international search report (Art. 21(3)) Court, Croton-on-hudson, NY 10520 (US). - before the expiration of the time limit for amending the (74) Agent: SMELAND, Tor; Regeneron Pharmaceuticals, claims and to be republished in the event of receipt of Inc., 777 Old Saw Mills River Road, Tarrytown, NY 10591 amnets(ue4.(h (US). - with sequence listing part of description (Rule 5.2(a)) (54) Title: HUMANIZED IL-6 AND IL-6 RECEPTOR (57) Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods f4 for making and using the mice. Mice comprising a replacement at an endogenous IL-6Ra locus of mouse ectodomain- encoding se quence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-en coding sequence at an endogenous mouse IL-6 locus.