baber/WOPTO huggingface dataset:
Patent JP-2944669-B2 (JP)
IPC: C07K7/23
Filed: 1988-07-18
Granted: 1999-09-06
Abstract: The present invention deals with LHRH antagonists which possess improved water solubility and while having the high antagonist potency of the basic peptides, are free of the edematogenic effects. These compounds are highly potent in inhibiting the release of gonadotropins from the pituitary gland in mammals, including humans. The compounds of this invention are represented by the formula X-R1-R2-R3-Ser-Tyr-R6-Leu-Arg-Pro-R10-NH2 wherein X is an acyl group derived from straight or branched chain aliphatic or alicyclic carboxylic acids having from 1 to 7 carbon atoms, or H2N-CO, R1 is D- or L-Pro, D- or L- DELTA 3-Pro, D-Phe, D-Phe(4-H1), D-Ser, D-Thr, D-Ala, D-Nal(1) or D-Nal (2), R2 is D-Phe or D-Phe(4-C1) R3 is D-Trp, D-Phe, D-Pal(3), D-Nal(1) or D-Nal(2), R6 is D-Cit, D-Hci, D-Cit(Q) or D-Hci(Q) and R10 is Gly or D-Ala where Q is lower alkyl of 1-3 carbon atoms and H1 is fluoro, chloro or bromo, and the pharmaceutically acceptable acid addition salts thereof and methods of use pertaining to these compounds.
Patent JP-H0237340-B2 (JP)
IPC: C07C209/68
Filed: 1981-11-26
Abstract: Aromatic amines (anilines) are obtained directly or via the corresponding cycloaliphatic amines by an aminating/hydrogenating reaction of phenols with ammonia and hydrogen over a supported palladium catalyst which also contains elements from group 1b, 2b or 7b of the periodic table as well as iron, cobalt or nickel, as such or in the form of their compounds, and, preferably, an inorganic base, said catalysts also having dehydrogenating properties.
Patent JP-H0558756-B2 (JP)
Inventor: ANDORUU JAKUSON SENSABOO JUNIA
IPC: A24D1/22
Filed: 1990-07-23
Abstract: The cigarette has a carbonaceous fuel element. A separate aerosol generator has a substrate bearing an aerosol forming material. The fuel element and substrate are arranged in a conductive relationship, so that the heat-stable substrate receives conductive heat transfer throughout the burning time of the fuel element. The fuel element is less than 30mm in length, with a density of at least 5 g/cc. An insulation material can surround part of the fuel element. The insulation is resilient and at least 15 mm thick. The cigarette also has a mouthpiece.
Patent JP-H0780839-B2 (JP)
IPC: C07D205/08
Filed: 1987-08-05
Abstract: A process for 4-halomethylazetidin-2-ones is provided which comprises mixing in an inert solvent a positive halogen reagent in the presence of a weak base with a  beta , gamma -unsaturated O-acylhydroxamate of the formula <CHEM> wherein R is protected amino, lower alkyl or phenyl substituted lower alkyl, R2 is a substituent such as lower alkyl which may be substituted by formyl, hydroxy, halogen, etc., and R1 is alkoxy, benzyloxy, etc. When R is a protected amino group, the process provides cis-4-halomethylazetidin-2-ones, while when R is alkyl or phenylalkyl, the trans isomer is obtained. The 4-halomethylazetidinones are useful intermediates for known antibiotic compounds.
Patent JP-4243741-B2 (JP)
IPC: C07C21/22
Filed: 1998-07-15
Granted: 2009-03-25
Abstract: Aliphatic and cycloaliphatic hydrocarbon chlorides are prepared by the reaction of the corresponding mono- or poly-alcohol, especially those of formula R<1>R<2>CH-OH (I), with phosgene or thionyl chloride, in the presence of a hexa-substituted guanidinium halide (II) or its hydrohalide, optionally grafted to a silica-based support to form (III). R<1> and R<2> = H or 1-30C aliphatic groups which may be substituted and may be unsaturated, 3 - 12C cycloaliphatic groups that may be substituted and may be unsaturated, 1- 30C alkoxy that may be substituted and may be unsaturated, aryl or aryloxy, that may be substituted, or R<1> and R<2> together form a 3 - 12C cycloaliphatic group that may be unsaturated and may be substituted R<3> - R<8> = 1 - 12C alkyl or 5 - 6 C cycloalkyl, optionally substituted, R<13> = 2 - 10C alkylene, A = Cl, Br, HCl2 or HBr2.
Patent JP-S6325367-B2 (JP)
IPC: G10L15/28
Filed: 1984-09-26
Abstract: PURPOSE:To process efficiently an event by recognizing the cause of an interruption by a monitor interruption processing part to start an interruption part of an I/O control process, reading out only unit data and then executing the format check of the data. CONSTITUTION:An FCP control process 14 is connected between each I/O control process (FCP) outof plural ones connected to a voice recognizing device and an application process (APL) 11 to recognize the cause of an interruption by an interruption processing part 131 of a monitor 13 at the time of event waiting such as command input and voice input and to start an interruption part 121 in the corresponding FCP 12. Only the unit data of the I/O data due to the interrupted event are read out by the interruption part 121 of the FCP 12, the control is instantaneously transferred to the monitor 13 and the format of said data is checked by the FCP control process 14 in accordance with the processing procedure of a schedular 132 in the monitor 13. Thus, the even processing can be performed efficiently.
Patent JP-H0241551-B2 (JP)
IPC: C08L95/00
Filed: 1982-11-26
Abstract: Cationic emulsions of bituminous binders of the type consisting of an organic phase formed of a bituminous binder dispersed in an aqueous phase containing a cationic emulsifying agent and an acid. The bituminous binder is a bitumen-polymer type binder and the acid present in the aqueous phase is a possibly hydroxylated mono or polycarboxylic acid, used in sufficient quantity that the pH of the said aqueous phase is comprised between 1 and 7. The bituminous binders of the bitumen-polymer type having passed through the said emulsions present an excellent aging behavior.
Patent JP-3853924-B2 (JP)
IPC: C08L23/12
Filed: 1997-09-02
Granted: 2006-12-06
Abstract: Propylene polymers (I), containing (a) 50-95 pts. wt.propylene homopolymer with an MFI 230/2.16 (ISO 1133) of 0.1-100 g/10 mins. and an isotacticity of at least 98%, (b) 5-50 pts. wt. ethylene copolymer with a density of 0.865-0.920 g/cm<3> containing 4-40 wt% 4-20C alkene-1 units, and (c) 0-1.5 pts. wt. nucleating agent, in which the total amount of (a) + (b) = 100 pts. wt. Also claimed is a process for the production of (I) by compounding the components at 200-250 degrees C in a mixing apparatus, preferably an extruder.
Patent JP-3522544-B2 (JP)
IPC: F16K7/14
Filed: 1998-08-24
Granted: 2004-04-26
Abstract: A fluid-switchable flow rate control system that permits free changing of the full scale flow rate and which can control a plurality of kinds of fluids with high precision. <??>The fluid-switchable flow rate control system controls the flow rate of fluid with the pressure P1 on the upstream side of the orifice member held about twice or more higher than the downstream pressure P2, the fluid-switchable flow rate control system comprising an orifice member 8 replaceable with another to provide a suitable orifice diameter according to the kind of fluid and the flow rate range, a control valve 2 provided on the upstream side thereof, a pressure detector 6 provided between the control valve 2 and the orifice member 8, and a flow rate calculation circuit 14 where, from the pressure P1 detected by the pressure detector, the flow rate Qc is calculated by the equation Qc = KP1 (K: constant), a flow rate-setting circuit 16 for outputting flow rate setting signal Qe, a flow rate conversion circuit 18 for multiplying the calculated flow rate signal Qc by the flow rate conversion rate k into switch-over calculated flow rate signal Qf (Qf = kQc) to change the full scale flow rate, and a calculation control circuit 20 to output the difference between the switch-over calculation flow rate signal Qf and the flow rate setting signal Qe as control signal Qy to the drive 4 of the control valve 2, thereby opening or closing the control valve to bring the control signal Qy to zero, thus controlling the flow rate on the downstream side of the orifice member. <IMAGE>
Patent JP-H07102139-B2 (JP)
IPC: C12Q1/68
Filed: 1990-09-11
Abstract: Methods for amplifying and detecting a predetermined target nucleic acid in a biological specimen are known, and can be accomplished even when there is a mismatch in a single position between a primer and the target nucleic acid. The mismatch is located at or near the 3 min end of the primer. Disclosed herein is a method for overcoming such a mismatch, and is particularly useful for detection of a nucleic acid sequence which is not fully known, or where there is considerable heterogeneity in DNA target from patient samples. The method is characterized by using a primer having a nucleotide with a thymine base at the position of the mismatch, the primer being used to prime the target and to form primer extension products.
Patent JP-H0523205-B2 (JP)
IPC: F16C11/06
Filed: 1985-11-01
Abstract: The anchoring of rigid axles (8, 18, 38) to the chassis (21, 26) of vehicles provided with vertically movable suspensions secured to the chassis is effected by means of a reduced number of separate connection elements reacting to longitudinal thrust and to the braking torque, and by the use of rotary translating joints which, when appropriately combined, absorb the transverse thrust and permit all the movements required for the axle for its articulation. 
<??>For each axle it is contemplated to use at least one of such joints which is secured on the one side to the base of the suspesion (10, 20) and, on the other side, to the axle (8, 18, 38). 
<??>The joint is constituted substantially by a rotatable pin (3, 13, 43) coupled either to a rotary translating sleeve (2, 12) or to a fork (37) rotating on a pin (36) of the axle (38).
Patent JP-3529108-B2 (JP)
IPC: A61B17/12
Filed: 1993-09-10
Granted: 2004-05-24
Abstract: An improved surgical instrument and sterile clip for ligating the vessel of a mammal. The clip has a pair of legs which are urged apart by the instrument to allow the clip to be placed on the vessel to be ligated.
Patent JP-4505084-B2 (JP)
IPC: C09K23/42
Filed: 1999-09-13
Granted: 2010-07-14
Abstract: A method for producing metallic colloid, wherein a metallic colloid is produced by doping a metallic ion solution and a pH compensating agent into a treatment solution in which a surface-active agent is doped into water, agitating the treatment solution while controlling the temperature thereof in a reductive atmospheric condition, and by reducing metallic ions. In a case where water is used with a capacity ratio of 400 parts to 500 parts with respect to the metallic ion solution of 1 part, the surface-active agent is a non-ion based surface-active agent, the amount of doping of the non-ion based surface-active agent is 0.2 to 2 times the amount of the metallic ion solution, the amount of doping of the reducing agent is 40 to 60 times the amount of the metallic ion solution, and the pH compensating agent is to adjust the pH of the treatment solution to neutral or weak alkalinity, wherein the amount of doping thereof is set in a range from 10 to 30 times the amount of the metallic ion solution where the concentration thereof is 5%, thereby obtaining a very active and high concentration metallic colloid.  <IMAGE>
Patent JP-2572937-B2 (JP)
IPC: C12P1/06
Filed: 1993-09-30
Granted: 1997-01-16
Abstract: The present invention concerns a new antibiotic substance arbitrarily denominated antibiotic A 40926 complex and its factors antibiotic A 40926 factor A antibiotic A 40926 factor B. antibiotic A 40926 factor B<sub>o</sub>, antibiotic A 40926 factor PA and antibiotic A 40926 factor PB, a process for producing them by culturing the new strain Actinomadura sp. ATCC 39727 or an A 40926 producing variant or mutant thereof and the use of these new antibiotic substances in the treatment of infectious diseases involving microorganisms susceptible to them. The antibiotic substances of the invention are glycopeptidic substances belonging to the vancomycin class or antibiotics which have binding capacity to Acyl-D-Alanyl-D-Alanine.
Patent JP-3344740-B2 (JP)
IPC: A61L27/34
Filed: 1992-10-16
Granted: 2002-11-18
Abstract: The invention relates to transparent, autoclavable, non-cytotoxic, essentially compact polyurethane embedding compositions which are prepared by reacting a) modified diphenylmethane diisocyanates with b) compounds with at least two reactive hydrogens, which contain or are composed of b1) at least one polyether-polyol with an average functionality of from 3 to 8, a hydroxyl number of from 200 to 1000 and an alkali metal ion content of from 150 to 1200 ppm or, preferably, a mixture of (b1) and castor oil and/or at least one polyetherpolyol (b2) with a functionality of from 2 to 3, a hydroxyl number of from 90 to 200 and an alkali metal ion content of less than 10 ppm in the presence or absence of c) catalysts and to a process for preparing the polyurethane embedding compositions and to the use thereof for articles used in medicine.
Patent JP-H0578364-B2 (JP)
Inventor: IBARAKI SHOICHI
IPC: C01B32/40
Filed: 1988-11-04
Abstract: A process for producing CO gas without using expensive conventional apparatus, in a simple manner in a high purity and with energy saving is provided, which process comprises a step of introducing a by-produced gas such as a mixed gas obtained by reforming or partially oxidizing hydrocarbons, steel converter gas, etc. into a pressure swing adsorption cycle (PSA) system; an adsorption step or adsorbing CO2, methane, CO, N2, H2, etc. in an adsorption column of the PSA system to obtain a H2-rich gas or a N2-rich gas passed; a step of depressurizing the adsorption column in the cocurrent direction to obtain a CO-rich gas discharged; a step of depressurizing the adsorption column direction in the counter current direction just prior to start of substantial desorption of methane and CO2 to obtain a CO2-rich gas discharged therefrom and having CO2 and methane concentrated therein; and a step of repressurizing the adsorption column using a H2-rich gas or a N2-rich gas obtained at the beginning of the adsorption step and the depressurizing step in the cocurrent direction.
Patent JP-H048537-B2 (JP)
IPC: D21F1/00
Filed: 1985-12-20
Abstract: 1. A method of manufacturing an insertion-type seam for making a web belt, especially a wire web, endless, in which the warp ends of each web side are interwoven with an auxiliary warp strip, characterized in that the warp ends after unravelling of the right-hand and the left-hand web sides are strung in a magazining bunch mechanically individually separated in accordance with the weaving order and alternatingly returned and rewoven about a central wire of any desired cross-sectional area, said central wire being disposed in the centre of the auxiliary warp strip and consisting of at least one wire, so that in accordance with the weaving progress a warp end of the right-hand and the left-hand web side alternately winds about the central wire, while the respective opposite warp is re-woven without being looped about the central wire, the warp ends after insertion into the shed made in accordance with the weaving order being beaten up in parallel to the selvedge.
Patent JP-3819651-B2 (JP)
IPC: G02F1/137
Filed: 1999-10-20
Granted: 2006-09-13
Abstract: PROBLEM TO BE SOLVED: To provide an active matrix type liquid crystal display device which adopts an IPS system using short pitch transparent comblike electrodes, and which realizes almost equal transmittance to that of a device using a liquid crystal material having negative dielectric anisotropy (comparable with a TN system) by using a liquid crystal having positive dielectric anisotropy which makes low driving voltage, fast response and lower cost possible. SOLUTION: A liquid crystal composition used has positive dielectric anisotropy, >=2.4 ratio of K11/K22, wherein K11 is the elastic modulus for splay deformation and K22 is the elastic modulus for twist deformation, and >=8 dielectric anisotropy and <=110 mPa.s rotational viscosity coefficient. The retardation d-Δ n is controlled to satisfy 0.28 μm<d.Δn<0.5 μm.
Patent JP-4361144-B2 (JP)
IPC: A61K38/09
Filed: 1997-10-31
Granted: 2009-11-11
Abstract: Disclosed is a sustained-release preparation comprising 1) a polymer of lactic acid having a weight-average molecular weight of about 25,000 to about 60,000 and 2) a physiologically active substance, and which releases the physiologically active substance over a period of at least about 5 months; the sustained-release preparation shows an almost continuous zero order release of the physiologically active substance over a period of as long as about 5 months.
Patent JP-2501277-B2 (JP)
IPC: A63B49/02
Filed: 1992-11-27
Granted: 1996-05-29
Abstract: A badminton racket (20) has a frame (21) with a head portion (22), a throat portion (23), and a shaft portion (24) which terminates in a handle portion (25). The racket (20) is lighter than prior badminton rackets, and the balance point or center of gravity of the racket is closer to the head end (33) than the handle end (30). <IMAGE>
Patent JP-3056856-B2 (JP)
IPC: B60W30/02
Filed: 1991-12-05
Granted: 2000-06-26
Abstract: PURPOSE:To maintain accumulated learning data and change running property according to the change in running conditions by inhabiting the learning based on actual data in the case where the actual data showing the running state of a car exceed the threshold set based on the data determined by learning control. CONSTITUTION:A main computer unit 50 outputs control signals to each controller such as engine controller 3 based on the signals sent from a position detecting sensor 18, a driver identifying means 48, a ROM 51 and a RAM 52. The ROM 51 stores a specified program in itself and the RAM 52 stores a reloadable program in itself, and the main computer 50 renews the learning program based on the signals from the position detecting sensor 18, etc., but the case where data change over the threshold set beforehand, the learning data are not changed. Therefore, highly reliable data can be maintained as much as possible, making it possible to perform the highly reliable learning control meeting the direction of drivers.
Patent JP-3521110-B2 (JP)
IPC: A61K38/00
Filed: 1997-12-04
Granted: 2004-04-19
Abstract: This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): <CHEM>   The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.
Patent JP-3493037-B2 (JP)
IPC: C07J7/00
Filed: 1992-11-27
Granted: 2004-02-03
Abstract: A 22-oxacholecalciferol derivative represented by general formula (I) and a process for producing the same efficiently by reducing the amount of by-products, wherein R1 represents hydrogen or hydroxy, and R2 and R3 may be the same or different from each other and represent each C1-C5 alkyl. This compound has potent activities of inducing differentiation and suppressing proliferation and is promising as antitumor agent, antirheumatic, psoriasis curative and remedy for hyperparathyroidism. <CHEM>
Patent JP-H0764748-B2 (JP)
IPC: A61K45/00
Filed: 1986-12-15
Abstract: Combination product containing a fibrinolytic agent and an analogue of prostacycline for the treatment of thrombosis.
Patent JP-H0783987-B2 (JP)
IPC: B25J9/04
Filed: 1985-12-10
Abstract: PCT No. PCT/EP85/00689 Sec. 371 Date Aug. 27, 1986 Sec. 102(e) Date Aug. 27, 1986 PCT Filed Dec. 10, 1985 PCT Pub. No. WO86/04009 PCT Pub. Date Jul. 17, 1986.A multi-axial industrial robot having a compact modular design for the drive system, which can be varied in numerous ways. The robot consists of a column or stand (1), with a rocker arm (7) swingably supported thereon and an outrigger (9) swingably supported on the rocker arm. The modular construction system is achieved by locating in the rocker arm (7) the oscillatory drive (26) for the outrigger (9), as well as the oscillatory drive (16) for the arm itself. Preferably, in the rocker arm are housed the complete drives (16, 26) with only the off-drive members (21, 31) protruding outwardly. Off-drive members (21, 31) are centered and connected non-rotatably with the stand (1) and the outrigger (9). As a result, the rocker arm (7) rotates about the fixed off-drive member (21) with respect to the housing. Drives (16, 26) consist each of a motor (11, 13) and a two-step timing-belt drive (17, 20 and 27, 30), whose second step can be a gear transmission.
Patent JP-2577466-B2 (JP)
IPC: C09D133/14
Filed: 1988-02-18
Granted: 1997-01-29
Abstract: PCT No. PCT/EP88/00117 Sec. 371 Date Aug. 16, 1989 Sec. 102(e) Date Aug. 16, 1989 PCT Filed Feb. 18, 1988 PCT Pub. No. WO88/06176 PCT Pub. Date Aug. 25, 1988.The invention relates to aqueous two-component paints containing customary additives and, if appropriate, pigments, for one-coat coating of finishing sheeting and continuous edging, characterized in that the paints containing as paint component (I) (A) 40 to 85% by weight, preferably 60 to 85% by weight, of an aqueous dispersion of a self-crosslinking polyacrylate resin, which contains as the groups capable of bringing about the self-crosslinking acid amide derivative groups corresponding to the general structural formula -CO-N(R1)-CH(R2)-OR3,  wherein R1=a hydrogen atom or a -CH(R2)-OR3 group, R2=a hydrogen atom or a -COOR4 group, R3=a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, preferably the methyl, ethyl, (iso)propyl or (iso)butyl radical, R4=an alkyl radical of 1 to 5 carbon atoms; (B) 5 to 50% by weight, preferably 7 to 20% by weight, of a melamine resin dispersed or dissolved in an aqueous medium (C) 0 to 40% by weight, preferably 5 to 20% by weight, of a urea resin dispersed or dissolved in an aqueous medium; (D) 5 to 30% by weight, preferably 6 to 15% by weight, of a polyol component; and (E) 0.01 to 5% by weight, preferably 0.1 to 1.5% by weight, of an amine component, (A) to (E) adding up to 100% by weight; the curing component (II) consists of a water-dilutable acid and the components (I) and (II) are mixed prior to application in a ratio of 0.05 to 3 parts by weight, preferably 0.05 to 2 parts by weight, of the pure curing component (II) to 100 parts by weight of the paint component (I). The invention further relates to a process for producing two-component paints as well as to their use for coating finishing sheeting and continuous edging.
Patent JP-3360823-B2 (JP)
IPC: C04B26/08
Filed: 1992-07-23
Granted: 2003-01-07
Abstract: PCT No. PCT/AU92/00375 Sec. 371 Date Jan. 12, 1994 Sec. 102(e) Date Jan. 12, 1994 PCT Filed Jul. 23, 1992 PCT Pub. No. WO93/02021 PCT Pub. Date Feb. 4, 1993A sheet or pad of sound deadening material comprising: (a) a polymeric component free of bitumen or asphalt such as natural or synthetic rubber, PVC, chlorinated polyethylene or ethylene vinyl acetate copolymer; (b) a filler such as calcium carbonate, barytes, talc, mica, magnesium carbonate or silica; (c) a compatibilising agent such as ricinoleic acid; and a tackifier such as pine rosin. Formulations may include a flame retardant, a polar additive, a polymer anti-oxidant, a heat stabilizer for PVC and a lubricant. Methods for forming such sheets or pads and for applying such sheets or pads to a metal panel are also provided.
Patent JP-3155984-B2 (JP)
IPC: C12N15/57
Filed: 1988-04-06
Granted: 2001-04-16
Abstract: The present invention provides a method for redesigning proteins to increase the stability of the protein by altering amino acid residue(s) that are in close proximity to the protein's metal ion binding site(s). Further, the invention is directed to proteins that have been redesigned to have enhanced stability according to the methods of this invention.