baber/WOPTO huggingface dataset:
Patent CZ-291794-B6 (CZ)
Title: 1-(1,2-Disubstituted piperidinyl)-4-substituted piperazine derivatives, process of their preparation and use as well as pharmaceutical compositions based thereon
Inventor: JANSSENS FRANS EDUARD
IPC: A61K31/4965
Filed: 1996-10-25
Abstract: In the present invention there are disclosed 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives of the general formula I, their N-oxide  forms, their pharmaceutically acceptable addition salts and their stereoisomeric  forms, wherein n is 0, 1 or 2; m is 1 or 2, whereby when m is 2 then n is 1; p is 1 or 2; =Q represents =O or =NRe3; X represents a covalent bond or -O-, -S-, -NRe3-; Re1 denotes Are1, Are1alkyl having 1 to 6 carbon atoms or di(Are1)alkyl containing 1 to 6 carbon atoms, where each alkyl group containing 1 to 6 carbon atoms can be optionally substituted with a group comprising hydroxy, alkyloxy with 1 to 4 carbon atoms, oxo or a ketalyzed oxo substituent; Re2 represents  Are2, Are2alkyl having 1 to 6 carbon atoms, Hete1 or Hete1alkyl having 1 to 6 carbon atoms; Re3 denotes hydrogen or alkyl containing 1 to 6 carbon atoms; L represents hydrogen, Are3, alkyl containing 1 to 6 carbon atoms, alkyl having 1 to 6 carbon atoms and being substituted with 1 or 2 substituents being selected from the group comprising hydroxy, alkyloxy having 1 to 6 carbon atoms, Are3, Are3alkyloxy having 1 to 6 carbon atoms and Hete2; alkenyl having 3 to 6 carbon atoms; Are3alkenyl having 3 to 6 carbon atoms, di(Are3)alkenyl having 3 to 6 carbon atoms or a radical of the general formula (a-1),  (a-2), (a-3), (a-4) or (a-5); Are1, Are2 and Are3 each represent phenyl or a substituted phenyl; Hete1 and Hete2 each represent a monocyclic or bicyclic heterocycle. The above described compounds exhibit antagonistic activity on the substance-P. Claimed is also a process of their preparation, pharmaceutical compositions in which they are comprised and their use as medicaments.
Patent CZ-291177-B6 (CZ)
Title: 7-deoxy-taxol derivatives, their antineoplastic use, and pharmaceutical compositions in which they are comprised
Inventor: HESTER JACKSON B
IPC: C07D413/12
Filed: 1993-12-13
Abstract: In the present invention there are disclosed 7-deoxy-taxol derivatives of the general formula I, in which Ri7 denotes either alphaRi71:betaRi72 and then one of the Ri71 and Ri72 represents -H and the other denotes a halogen and Ri8 represents -CHi3, or Ri7 denotes alphaH:betaRi74, wherein Ri74 and Ri8 together form a cyclopropane ring, or Ri7 is a halogen atom and Ri8 is -CHi3. The compounds are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.
Patent CZ-298667-B6 (CZ)
Title: Polyolefin fibers, polyolefin yarns, and textile fabrics produced therefrom
Inventor: ROTZSCH MANFRED
IPC: D01F1/10
Filed: 1998-05-07
Abstract: In the present invention, there are disclosed polyolefin fibers and polyolefin yarns of high strength and elongation and textile fabrics produced therefrom consisting of modified propylene polymers, unmodified propylene polymers and adjuvants. Such fibers are produced by melting the polyolefin mixtures in an extruder, transferring the melt by extrusion pumps to the spinnerets and drawing off the extruded filaments by high-speed galettes and/or winders. The polyolefin fibers and polyolefin yarns of high strength and elongation and the textile fabrics produced therefrom are suitable for the production of textiles for the home, multilayered textiles, industrial textiles, nonwoven materials intended for use in medicine and hygiene, and elastic hygiene articles.
Patent CZ-288897-B6 (CZ)
Title: Phenanthridine derivative, pharmaceutical preparation in which it is comprised and use thereof
Inventor: MASUDA AKIRA
IPC: C07D221/12
Filed: 1997-11-21
Abstract: The present invention relates to a phenanthridine derivative of the general formula I or II, in which Ri1 represents a non-substituted alkyl group containing 1 to 5 carbon atoms, an alkyl group containing 1 to 5 carbon atoms and substituted with a hydroxyl group, further by an alkoxyl group containing 1 to 5 carbon atoms, an alkoxycarbonyl group containing 2 to 5 carbon atoms, an acetyl group, a halogen, a carbamoyl group, a phenyl group or a phenyl group being substituted by a methoxyl group, or it represents an alkenylmethyl group containing 3 to 5 carbon atoms, R represents a non-substituted aliphatic hydrocarbon group containing 2 to 6 carbon atoms or an aliphatic hydrocarbon group having 2 to 6 carbon atoms and being substituted by alkyl group containing 1 to 5 carbon atoms, a halogen or a hydroxyl group, Y and Z represent independently on each other a hydrogen atom, a hydroxyl group or alkoxyl group containing 1 to 5 carbon atoms, or Y and Z are coupled to form a methylenedioxy-
Patent CZ-285129-B6 (CZ)
Title: Ophthalmic preparations containing combinations of and beta-adrenergic antagonists
Inventor: BALDWIN JOHN J
IPC: A61K31/535
Filed: 1992-04-09
Abstract: Combinations of a  beta -adrenergic antagonist and a topical carbonic anhydrase inhibitor are particularly useful in the treatment of ocular hypertension, especially in patients insufficiently responsive to treatment with  beta -adrenergic antagonists. <IMAGE>
Patent CZ-284855-B6 (CZ)
Title: Salts of clavulanic acid with diamines, process of their preparation, and antibacterial pharmaceutical compositions based thereon
Inventor: WEBER PIETER GIJSBERT
IPC: A61P31/04
Filed: 1994-03-22
Abstract: New diamine salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.
Patent CZ-298059-B6 (CZ)
Title: Method of inserting coils into grooves of stator lamination pack of electric machines and device for making the same
Inventor: SADIKU SADIK
IPC: H02K15/06
Filed: 1998-01-15
Abstract: The present invention relates to a method of inserting coils into grooves of stator lamination pack of electric machines wherein the method is characterized in that in a first phase of the insertion process, star-shaped insertion elements (16), short draw-in plates (14) and long draw-in plates (18) with their upward open ends are moved from a first starting position forward through a stator aperture over upper edge (26) of the stator into a second position whereupon in a second phase of the insertion process said star-shaped insertion elements (16) and short draw-in plates (14) are further moved together forward while at the same time said long draw-in plates (18) are retracted back up to a third position slightly above the stator upper edge (26) whereupon in a third phase of the insertion process said star-shaped insertion elements (16), short draw-in plates (14) and long draw-in plates (18) are moved back from the third position into the starting position. Disclosed is also a device for making the above-described process, said device operation being characterized in that in a first phase of the insertion process, short plates (14) are moved by a first drive (22), and long plates (18) are synchronously moved by second drive (24), from a starting position into a second position, while in a second phase the second drive is reversed to retract the plate holder (20) along with the long plates (18) to slightly above the upper edge of the stator, whereby said first drive (22) is connected to the star-shaped insertion element (16) for performing forward motion thereof up to the third position at which the drives (22, 24) are connected to the star-shaped insertion element (16, optionally to said plate holder 20) to move them back into the starting position.
Patent CZ-292950-B6 (CZ)
Title: Electromagnetically controlled valve
Inventor: EICHENDORF ANDREAS
IPC: F02M51/00
Filed: 1998-11-26
Abstract: The invented valve has a magnet coil (1) with a core (2) with a longitudinal hole (5) and encompassed, at least partially, by the magnet coil (1), further an armature (17), a closable valve body (14) controlled by the armature (17) and communicating with a fixed valve seat (18), a connecting part (8) having the form of a pipe and being arranged behind the core  (2), and a magnetic flux narrowing spot (10) interconnecting the core (2) and the connecting part (8). The core (2) is provided on its outer surface and close to the magnetic flux narrowing spot (10) with a reinforcing insert (31) having the form of a ring. By making use of the ring-shaped insert (31), it is possible to make advantage of the valve pipe (9) structure with said magnetic flux narrowing spot (10) and at the same time to achieve stability that is necessary for high-pressure valves. Especially advantageous is when the insert (31) is produced either of electrically non-conducting material, or is at least at one point interrupted and fastened in electrically insulated manner. This arrangement prevents generation of eddy currents in the insert (31) located at least partially inside the influence of the magnetic coil (1) magnetic field that could negatively affect switching times of the valve.
Patent SK-279880-B6 (SK)
Title: Discrete individual micro-capsules of micro-organisms, and process for their preparation
Inventor: RUTHERFORD WILLIAM M
IPC: C12R1/01
Filed: 1991-05-16
Abstract: Discrete individual bacteria micro-capsules being fatty acid coated are prepared by mixing freez-dried bacterial cultures with fatty acid and encapsulating said mixture on a rotary disc, whilst fat acid is C12 - C24 fatty acid, especially stearic acid. The micro-capsules comprise from about 50 to 90 percent by weight of the fatty acid component and the rest is added with bacteria Enterococcus faecium. A micro-capsule particle size ranges from 75 to 300 um. A process includes obtaining bacterial culture of dried bacteria, contacting thereof with from 50 to 90 by weight of a fatty acid melt, and processing said mixture in a rotary disc processor to provide individual coated free-flowing bacteria capsules. A rotary disc can be run at the rate of from 2,000 rpm to 4,000 rpm, preferably about 2,500 rpm to 3,200 rpm with a feed rate of from 50 grams to 200 grams per minute.
Patent SK-278283-B6 (SK)
Title: Substituted piperidinecarboxamides, method of their manufacture, pharmaceutical drugs containing them and their application
Inventor: ASK ANNA-LENA
IPC: A61P25/04
Filed: 1990-12-21
Abstract: This patent contains the description of the substituted piperideinecarboxamides with a general formula according to the figure (IV), where the symbol called R1 represents the group of alkyl containing 2 up to 6 carbon atoms or the alkooxylalkyl group with the formula of R4O(CH2)m-. The symbol called R4 means the alkyl group containing 1 up to four carbon atoms and the value of m is 2 to 4, the radicals R2 and R4 are equal or different and they always mean the alkyl group containing 6 carbon atoms, the radicals R2 a R3 can create a ring according to the formula (CH2)n, where the value of n is 4 up to 6, however, it also is possible one of the radicals R2 and R2 means a hydrogen atom and the second one represents the alkyl group containing 1 up to 6 carbon atoms with a direct or branching chain, the structure of these compounds is the same as in the case of the salts which can be accepted from pharmaceutical point of view, the production of the above mentioned compounds is based on the ester or nytril hydrolysis, while the appropriate acid is created which reacts with oxalylchloride and with the appropriate amine subsequently, or in the case of the amination with an appropriate outgoing ester. This patent also contains a description of pharmaceutical means containing the above mentioned compounds together with an application of these compounds for the production of the pharmaceutical mean having an anaesthetic or analgesic effect.
Patent CZ-303319-B6 (CZ)
Title: Piperidin-1-yl-ethanesulfonyl- phenyl ester, process for its preparation and medicament containing thereof
Inventor: ALANINE ALEXANDER
IPC: A61P25/24
Filed: 2001-08-20
Abstract: The present invention relates to piperidin-1-yl-ethanesulfonyl- phenyl ester of the general formula I in which R represents a) -C(O)(CHi2)inC(O)OH, b) (Re2)(Re3) N-methylphenylcarbonyl-, wherein each Re2a and Re3 are independently from each other hydrogen or alkyl containing 1 to 7 carbon atoms or a cyclic tertiary amine group being selected from the group consisting of pyrrol-1-yl, imidazol-1-yl, piperidin-1-yl, piperazin-1-yl and morpholin-4-yl group being each optionally substituted by an alkyl containing 1 to 7 carbon atoms, c) -P(O)(OH)i2 or d) -C(O)(CHi2)inNHC(O)(CHi2)inN(Re2)(Re3), wherein Re2 and Re3 are as defined above and n is 1, 2, 3 or 4; and to pharmaceutically acceptable acid addition salts thereof. The invention also relates to a process for preparing the above-describe compound as well a medicament in which the compound is comprised wherein the medicament is suitable for the treatment of diseases associated with the NMDA-receptor-subtypes blockers, such as neurodegenerative diseases, especially for the treatment or prevention of stroke.
Patent CZ-300300-B6 (CZ)
Title: Process for producing profiled frames of windows, doors and door cases
Inventor: HALES JOSEF
IPC: B29C48/90
Filed: 2004-03-08
Abstract: Profiled frames of windows, doors and door cases are produced from thermosetting plastic resins in such a manner that a mixture of thermosetting plastic resin, hardening agent and a catalyst and optionally also a filler, for example a fibrous filler is continuously molded within a heated extrusion device and subsequently hardens by cooling to room temperature.
Patent CZ-304322-B6 (CZ)
Title: Compounds intended for use as traps of air pollutants, means for trapping air pollutants, process for its preparation and method of trapping air pollutants
Inventor: Kubánek Jaroslav
IPC: B01D53/02
Filed: 2007-07-18
Abstract: In the present invention, there are disclosed compounds of the general formula I in which M denotes a hydrogen atom or an atom of a metal being selected from the group consisting of Ca, Mg, Na and K, x is an even integer ranging from 6 to 12, y is 0 or 1, z is 1 or 2, for use as tarps of air pollutants, further means of trapping air pollutants comprising at least one compound of the general formula I and a porous carrier, a process for preparing the means as well as method of trapping air pollutants.
Patent CZ-306816-B6 (CZ)
Title: A joint implant and the method of its manufacture
Inventor: Joska Luděk
IPC: A61F2/36
Filed: 2014-12-22
Abstract: A joint implant, in particular a revision joint implant for performing reoperations and replacing failing primary total replacements of hip or shoulder joints, consists of the anchoring shaft (1) with the conical neck (2) for attaching the joint head (6), movably located in the implanted acetabulum (7), while the outer surface of the transition part between the anchoring shaft (1) and the conical neck (2) is provided with the protective porous surface layer (4) formed by plasma titanium spraying and/or hydroxyapatite and adapted to prevent the ingress of wear particles, generated the by relative movement between the joint head (6) and the acetabulum (7), into the surrounding tissue. The outer surface of the anchoring shaft (1) is then, in the length of l.sub.1.n., in the range of 2/5 to 4/5 of the total length l of the bone shaft (1) in the direction of the protective surface layer (4), provided with the integration surface layer (5), made directly in the form of a base material of the anchoring shaft (1) of the extending nanotubes and adapted for integration and secondary fixation of the anchoring shaft (1) into the bone tissue.
Patent CZ-305943-B6 (CZ)
Title: Outdoor cottage for individual breeding of animals
Inventor: Vegricht Jiří
IPC: A01K1/02
Filed: 2015-02-26
Abstract: The present invention relates to an outdoor cottage for individual breeding of animals comprising walls (1) and a roof (2), wherein the walls (1) are formed by a single-layer jacket (11), while the roof (2) is comprised of an external jacket (21) and an internal jacket (22) with a heat-insulating filling material (7) inserted therebetween. A ventilation hole (3) is arranged in the roof (2) and a man-hole cover (4) adapted to making a ventilation gap (5) is arranged above the ventilation hole (3).
Patent SK-287638-B6 (SK)
Title: Clamp for skylights and smoke extractors
Inventor: CAODURO CARLO
IPC: E04D13/03
Filed: 2000-10-09
Abstract: A skylight assembly (1) or a fume exhaustion device with a cover (L) consisting of a frame (T) and a dome (C) coupled with each other by means of a clamp. The assembly according to the present invention comprises: a first element (2) connected to the frame (T); a second element (3) having the free end (4) resting externally on the dome (C) above the frame (T) and the opposite end (5) removably coupled to the first element (2) by means of a fastening mechanism. Said fastening mechanism consists of at least one hinge (6) which forms an axis of rotation (X) of the first element (2) and the second element (3), said axis (X) of rotation being substantially parallel to a plane defined by the frame (T), and fixing means for locking the second element (3) on the dome (C).; At least one hinge (6) is placed in corresponding manner to said means of fixing (11) and comprises a concave seat (6a) with a substantially C-shaped transverse profile, and a pin (66) having a transverse profile mating with said concave seat (6a). Said pin (6b) and said concave seat (6a) being removably coupled by sliding them reciprocally in an axial direction following the common axis of rotation (X).
Patent SK-285540-B6 (SK)
Title: Crystal modification A of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8- diazabicyclo-[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3- quinoline carboxylic acid, method for producing the same, and its use in pharmaceutical preparations
Inventor: HIMMLER THOMAS
IPC: C07D471/04
Filed: 1999-11-15
Abstract: The invention provides a defined crystal modification A of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]nonan-8- yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of formula (I), method for producing the same, and its use in antibacterial pharmaceutical preparations. The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo- [4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of formula (I) by its characteristic X-ray powder diffractogram and its differential thermal diagram.
Patent CZ-300823-B6 (CZ)
Title: Iron and dextran compound
Inventor: ANDREASEN HANS BERG
IPC: A61P43/00
Filed: 1999-03-24
Abstract: The present invention relates to a therapeutic composition for prophylaxis or treatment of iron deficiency in an animal or human and suitable for parenteral administration consisting essentially of a pharmaceutically effective amount of an iron-dextran compound consisting of hydrogenated dextran in stable association with ferric oxyhydroxide, wherein said hydrogenated dextran has a weight average molecular weight 0.7 to 1.4 kg/mole,(preferably 1 kg/mole) and a number average molecular weight of 0.4 to 1.4 kg/mole, wherein 90 pwercent by weight of the dextran has a molecular weight of less than 2.7 kg/mole and the remaining 10 percent by weight of the dextran having a molecular weight of 2.7 kg/mole or greater has a weight average molecular weight of less than 3.2 kg/mole, wherein said hydrogenated dextran has been purified by membrane filtration, wherein said membrane has a cut-off value of 0.34 to 0.8 kg/mole. The containing is prepared using membrane processes for removing dextrans of higher molecular weight than approximately 2,7 kg/mole and membrane processes for removing sugars of molecular weight less than approximately 0.34 kg/mole-1 from hydrogenate dextran prior precipitation of ferric hydroxide in the presence of said dextran followed by subsequent heating and purification.
Patent CZ-298544-B6 (CZ)
Title: Turbine blade retention device
Inventor: GEKHT EUGENE
IPC: F01D5/02
Filed: 1999-11-22
Abstract: The present invention discloses a turbine blade retention device (13, 14) comprising: a blade (7) root (8) retention clip (13) having an elongated web (15) and including a forward and a rearward transverse flange (16) extending radially outwardly and extending laterally from forward and rearward ends of the web (15), the web (15) adapted to be disposed in a gap (12) with the height of at least one flange (16) when the web (15) rests on the slot (4) floor (11) not exceeding the gap depth to permit sliding engagement of the blade root in the slot, the flanges (16) of said clip (13) adapted to engage the forward and rearward faces (2, 3) of the rotor hub disk (1) and the forward and rearward faces of an associated blade (7) root (8) when held radially outward once the blade (7) root (8) is engaged in the slot (4). The device (13, 14) further comprises clip securing means (14) for holding the clip (13) radially outward to engage the forward and rearward faces of the blade (7) root (8) and rotor hub disk (1) when assembled. There is also described a method of assembling turbine blades on a rotor hub disk into an axially symmetric turbine rotor assembly, the method comprising: installing a blade (7) root (8) retention clip (13) in the gap (12); axially sliding a blade (7) root (8) into each slot (4); axially sliding a spacer (14) between the slot (4) floor (5) and the clip (13); and securing the spacer (14) in position to retain the clip (13) and blade (7) root (6) in the slot (4).
Patent CZ-294904-B6 (CZ)
Title: Saredutant and the pharmaceutically acceptable salts thereof to produce a medicament used to treat or prevent mood disorders, adjustment disorders or mixed anxiety-depression disorders
Inventor: EMONDS-ALT XAVIER
IPC: A61K31/451
Filed: 2000-04-25
Abstract: The present invention relates to the use of saredutant and the pharmaceutically acceptable salts thereof to produce medicaments that are used to treat or prevent mood disorders, adjustment disorders or mixed anxiety-depression disorders.
Patent CZ-302536-B6 (CZ)
Title: Method for grinding kingpins and crankshaft crank bearings
Inventor: JUNKER ERWIN
IPC: B24B41/06
Filed: 2000-04-20
Abstract: The present invention relates to a method for grinding kingpins (11) and crank bearings (12) of a crankshaft (1) being supported at its ends and clamped such that it is driven centrally in rotatable manner about its king pins (11) wherein the method is characterized in that the kingpins (11) and the main bearings (12) are finish-ground in one single clamping. At least grinding of the kingpins (11) is carried out in separate steps of rough grinding and finish grinding. First, the kingpins (11) are rough-ground, then the main bearings (12) are finish-ground and finally the kingpins (11) are finish-ground.
Patent CZ-294806-B6 (CZ)
Title: Fresh-air blower
Inventor: SKALICKY JOSEF
IPC: B60H1/03
Filed: 2001-10-30
Abstract: The present invention relates to a fresh-air blower for automobiles having on a body (1) a ring gear (6) serving for rolling thereon toothed wheels (10) of rotary plates (9), a fixed grating (4) with conical holes (13), and a movable grating (11) with conical holes (12) sliding on said fixed grating (4).
Patent CZ-301189-B6 (CZ)
Title: Electronic label
Inventor: DROZ FRANCOIS
IPC: B42D15/10
Filed: 2000-12-22
Abstract: In the present invention, there is disclosed a flexible electronic label including a flexible support (2), an antenna (3) and an electronic chip (4), wherein the electronic chip is connected to the antenna (3). Protection of the chip (4) is provided by a rigid element (1, 5) connected at least to one side of the support.