baber/WOPTO huggingface dataset:
Patent CZ-301538-B6 (CZ)
Title: Process for preparing zolmitriptan
Inventor: VOSLAR MICHAL
IPC: A61K31/422
Filed: 2007-02-26
Abstract: In the present invention, there is disclosed a process for preparing zolmitriptan of the general formula III in which reduction of diazonium salt to (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one is carried out by the action of an alkali metal disulphite, preferably by sodium disulphite, and in which the product of the general formula III is first isolated in the form of a toluene solvate that is then further converted to a non-solvates form.
Patent CZ-304602-B6 (CZ)
Title: Crystallization process of (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine hydrochloride)
Inventor: RIDVAN LUDĚK
IPC: A61K31/381
Filed: 2009-09-02
Abstract: The invented crystallization process of duloxetine hydrochloride of the general formula I is characterized in that a duloxetine hydrochloride suspension comprised is mixed in a mixture of an aprotic solvent, being selected from the group consisting of esters or ketones, and a protic solvent at a boil temperature of the solvent mixture for a period of 0.5 to 1 hour and subsequently it is cooled down during 1 hour to a temperature in the range of from about 30 to about 40 degC and is mixed at this temperature for a period of at least 1 hour. The crystalline duloxetine hydrochloride is characterized in that at least 65 percent of crystals have elongation parameter value within the range of 1 to 2 or at least 85 percent of crystals have the elongation parameter value within the range of 1 to 3. The duloxetine hydrochloride is further characterized in that its apparent density is greater than 0.25 g/cme3, its percentile value d(0.9) is at least 80 microns, its percentile value d(0.5) is at least 30 microns, and its percentile value d(0.1) is at least 10 microns.
Patent CZ-303061-B6 (CZ)
Title: Process for preparing (-)-1-(3-hydroxypropyl)-5-[(2R)-2-({2,2,2-trifluoroethoxy)phenoxyethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide
Inventor: VLASAKOVA RUZENA
IPC: A61K31/4045
Filed: 2010-11-12
Abstract: The present invention relates to a novel process for preparing (-)-1-(3-hydroxypropyl)-5-[(2R)-2-({2,2,2-trifluoroethoxy)phenoxyethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide of the general formula I, known also under the name silodosin, and salts thereof wherein the preparation process takes place in four stages: the stage A is alkylation of a secondary amine of the general formula II by an alkylating agent of the general formula III; the stage B is N-hydrogenolysis of a tertiary amine of the general formula IV by hydrogen onto a metallic catalyst; the stage C is hydrolysis of a nitrile of the general formula V by treating thereof with alkali agents; and the stage D is O-debenzylation of an amide-ether of the general formula VI by means of hydrogenolytic or tralkylsilylhalide agents.
Patent CZ-307414-B6 (CZ)
Title: An asphalt mixture reinforced with plant fibres
Inventor: GALLO PETER
IPC: E01C7/26
Filed: 2017-06-16
Abstract: An asphalt mixture for structural road subbases reinforced with plant fibres, comprises 65.9 to 95.89% by weight of aggregate having a size of up to 32 mm, consisting of a mixture of coarse and fine crushed aggregate and a filler, up to 30% by weight of an asphalt R-material, 4-7% by weight of an asphalt binder, and 0.1 to 0.5% by weight of plant fibres in the length of 3 to 60 mm in the form of yarn composed of 1 to 10 fibres with a fineness of 50 to 500 tex selected from a group of flax fibres and hemp fibres.
Patent SK-287154-B6 (SK)
Title: Aqueous intravenous infusion solution or pharmaceutical solution comprising levosimendan
Inventor: BACKSTROM REIJO
IPC: A61K31/00
Filed: 2000-09-08
Abstract: An aqueous intravenous infusion solution comprising levosimendan or a salt thereof as an active ingredient, the pH-value of the solution being lower than 5, preferably 4.5 or lower, and optionally a solubility enhancing agent. A pharmaceutical solution comprising (a) levosimendan or a pharmaceutically acceptable salt thereof as an active ingredient; (b) pharmaceutically acceptable organic solvent comprising ethanol; (c) a stability enhancing amount of pharmaceutically acceptable organic acid having pKa in the range of from 2 to 4; and optionally (d) a water-solubility enhancing agent.
Patent CZ-292367-B6 (CZ)
Title: Push-in plug
Inventor: FISCHER RAINER
IPC: F16B13/02
Filed: 1998-10-19
Abstract: The present invention relates to a push-in plug (1) made from plastic and having at least one shank (2) intended for introduction into a drilled hole (8), whereby on the shank (2) there are arranged expansion segments (4) lying opposite one another in pairs. For improvement of the holding force, the expansion segment (4) is formed by a wedge element (5), which is held on the outer surface (3) of the shank (2) so as to be axially displaceable and which is displaced, when the push-in plug (1) is pushed into the drilled hole, into a position lying in front of an inclined surface (6) formed on the shank (2), which inclined surface (6) rises towards the insertion end (14) of the push-in plug (1). The wedge elements (5) are integrally joined to the shank (2) by means of an injection-molded bridge (7) so that when the push-in plug (1) is inserted into the drilled hole (8) the wedge element (5) axially displaces in the direction toward the drilled hole (8) orifice in front of the inclined surface (6) and both opposite wedge elements (5) squeeze against each other to an outside dimension corresponding to the diameter of the drilled hole (8) in a wall (9). Action of pulling load on the shank (2) causes shift of the wedge element (5) on the inclined surface (6) in the direction toward the push-in plug (1) plug-in end (14) up to a distance enabling wedging of the push-in plug (1) in the drilled hole (8).
Patent CZ-295720-B6 (CZ)
Title: Stabilized pharmaceutical composition and process for its preparation
Inventor: SAWAI SEIJI
IPC: C07K7/54
Filed: 2000-06-29
Abstract: In the present invention, there is disclosed a stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula I wherein Re1 represents a hydrogen atom or an acyl group and Re2 and Re3 being the same or different and represent a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable salt thereof and a stabilizer. Described is also a process for preparing the above-indicated pharmaceutical composition.
Patent CZ-299487-B6 (CZ)
Title: Phenylpiperazine derivatives, process of their preparation and pharmaceutical preparations in which they are comprised
Inventor: FEENSTRA ROELOF W
IPC: A61P25/00
Filed: 2002-02-19
Abstract: The present invention relates to novel phenylpiperazine derivatives of the general formula I wherein:- R represents the group of the general formula (a) or of the general formula (b), and salts thereof, further process of their preparation by reacting a compound of the general formula 2 with the compound of the general formula L-(a) or of the general formula L-(b), wherein L denotes a leaving group and the symbols (a) and (b) are the groups of the general formula a, or of the general formula b, under basic conditions, and pharmaceutical compositions in which the derivatives are comprised. These compounds are (partial) dopamine Di2 receptor agonists and are useful for treating central nervous system disorders, in particular Parkinson's disease.
Patent SK-285166-B6 (SK)
Title: Method for producing a container having a pressure compensation opening, and container produced according to said method
Inventor: KUEHN TORSTEN
IPC: B65D1/02
Filed: 2001-03-14
Abstract: The invention relates to a method for producing a container (1) that comprises an outer container (2), an inner pouch (34) disposed therein, and a pressure compensation opening (10) provided in the outer container (2). The invention also relates to a container (1) produced by the inventive method. A preform consisting of two coaxial tubes is produced by a coextrusion blow-molding method using a blow mold, whereby a bottom seam (5) is produced that protrudes outwardly. The aim of the invention is to provide a method by which a container (1) is provided with a pressure compensation opening (10) in the outer container (2) without impairing the tightness of the container (1) while reducing the reject rate and increasing productivity. To this end, the bottom seam (5) is partially cut away and a force is applied on the preform that still has a temperature of 40 DEG C to 70 DEG C, said force acting in the direction of the seam. Said force breaks up the bottom seam (5) and plastically deforms it so that a pressure compensation opening (10) is formed in the bottom area (4).
Patent AT-510720-B8 (AT)
Title: Dampferzeugungseinrichtung
Inventor: VOELKERER KLAUS ING
IPC: F01K19/08
Filed: 2011-03-02
Granted: 2012-09-15
Abstract: Bei der Erfindung handelt es sich um eine Einrichtung sowie ein Verfahren zur Erzeugung von Dampf für mehrstufig beaufschlagte Arbeitsmaschinen, wobei einem Dampferzeuger ein Überhitzer nachgeschaltet ist, wobei der Ausgang des Überhitzers mit der Kraftmaschine verbunden ist. Um solche Einrichtung auch in kleinerem Maßstab wirtschaftlich betreiben zu können, ist je Arbeitstufe (a-e) der Arbeitsmaschine (1) ein Überhitzer (5-9) vorgesehen ist, dass zwischen dem einen oder mehreren Dampferzeugern (15-19) und jedem Überhitzer (5-9) ein Dampfstrahlverdichter (10-14) vorgesehen ist, in welchem eine von der jeweils nächst folgenden Stufe ausgehende Rückführungsleitung (26-29) für überschüssigen Arbeitsdampf mündet.
Patent EP-1905277-B8 (EP)
Inventor: BACHMANN VOLKER
IPC: H01L33/44
Filed: 2006-06-28
Granted: 2011-02-23
Abstract: An illumination system, comprising a radiation source and a luminescent material comprising a phosphor capable of absorbing a part of light emitted by the radiation source and emitting light of a wavelength different from that of the absorbed light; wherein said phosphor is a europium-activated oxonitridoalumosilicate of general formula AE1−y−zLnySi3-xAlx−aBa O1+x−yN4−x+y:Euz, wherein AE is an alkaline earth metal selected from the group of Sr, Ca, Ba, Mg and Zn; Ln is a lanthanide metal selected from the group of La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y; B is a trivalent metal selected from the group of boron, gallium and scandium and a 0≰a<2, 0≰x<2, 0≰y≰1, 0.001<z≰0.1 provides white or colored illumination with high efficacy. The invention also relates to a luminescent material comprising a phosphor capable of absorbing a part of light emitted by the radiation source and emitting light of a wavelength different from that of the absorbed light; wherein said phosphor is a europium-activated oxonitridoalumosilicate of general formula AE1−y−zLnySi3−xAlx−aBaO1+x−yN4−x+y: Euz, wherein AE is an alkaline earth metal selected from the group of Sr, Ca, Ba, Mg and Zn; Ln is a lanthanide metal selected from the group of La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y; B is a trivalent metal selected from the group of boron, gallium and scandium and 0≰a<2, 0≰x<2, 0≰y≰1. 0.001<z≰0.1.
Patent BR-PI0407311-B8 (BR)
Inventor: WESTPHAL OTTO
IPC: A61K35/74
Filed: 2004-02-18
Abstract: The present invention relates to a composition comprising bacterial endotoxin, fetal hemoglobin and, optionally, additional components such as additional fetal liver components and a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that bacterial endotoxin and fetal hemoglobin display a pronounced synergistic biomedical activity. The composition of the invention finds a variety of applications including the stimulation of the immune system, the prevention and/or treatment of cancer, infections such as viral infections and/or allergic conditions and the reversion of age-related immune imbalances. <IMAGE>
Patent BR-PI0411431-B8 (BR)
Title: stents biodegradáveis
Inventor: ANDREAS LENDLEIN
IPC: A61F2/02
Filed: 2004-06-09
Abstract: stents biodegradáveis. a presente invenção refere-se a um stent biodegradável, produzido de um material de smp, para aplicação na área vascular ou não vascular.
Patent BR-PI0903737-B8 (BR)
Title: disposição construtiva pré fabricada para aplicação e modelagem de carga de tração em tirantes intermaxilares, usados em placas intrabucais de avanço mandibular para o combate do ronco e da apnéia obstrutiva do sono
Inventor: HUMBERTO LUIS OLSEN
IPC: A61C7/36
Filed: 2009-09-09
Abstract: disposição construtiva pre fabricada para aplicação e modelagem de carga de tração em tirantes intermaxilares, usados em placas intrabucais de avanço mandibular para o combate do ronco e da apneia obstrutiva do sono. a presente patente refere-se a uma disposição construtiva pré fabricada que, aplicada ao conjunto formado pelas placa intra bucal maxilar (1) e placa intra bucal mandibular (2), é capaz de realizar o avanço mandibular terapêutico para o combate do ronco e apnéia obstrutiva do sono e permitir, durante o seu uso, contração muscular isotônica concêntrica e excêntrica. a aplicação e modelagem de carga de tração é transmitida por tirante intermaxilar (3) e cabo de tração do mini dinamômetro (7) a pontos de aplicação de força específicos localizados, a saber: arco elíptico maxilar (4) na região inter caninos maxilar, retentores mandibulares direito (5d) e esquerdo (5e) do tirante intermaxilar e mini dinamômetro direito (6d) e esquerdo (6e), na região de molares mandibular. o aumento ou diminuição da carga de tração permite maior ou menor avanço mandibular, este último mantido em virtude da constante elástica do polímero constituinte do tirante intermaxilar (3) e do aço utilizado na construção da mola helicoidal (8) presente no mini dinamômetro direito (6d) e esquerdo (6e). a disposição construtiva ora apresentada pode ser adaptada a conformação dentária do sujeito através da máquina plastificadora a vácuo (mp) ou através de colagem simples dos elementos já descritos nas posições de referências dentárias citadas.
Patent AU-2012361510-B8 (AU)
Title: Humanized anti-Epiregulin antibody, and cancer therapeutic agent comprising said antibody as active ingredient
Inventor: SHIRAIWA HIROTAKE
IPC: C12N1/15
Filed: 2012-12-28
Granted: 2018-05-10
Abstract: The present inventors succeeded in producing an anti-Epiregulin antibody that exhibits a species crossreactivity between a non-human animal crab-eating monkey and a human animal, an anti-Epiregulin antibody that rarely undergoes chemical decomposition, an anti-Epiregulin antibody that has a decreased isoelectric point, an anti-Epiregulin antibody that has an elevated thermal denaturation midpoint temperature and an anti-Epiregulin antibody that is reduced in the amount of aggregates, by properly substituting an amino acid residue in the sequence for a variable region of a humanized EP27 antibody that can exhibit a cytotoxic activity and a neutralization activity on an anti-human Epiregulin-expressing cancer cell (i.e., a cancer cell that exhibits an anti-human Epiregulin) to thereby inhibit the proliferation of the cancer cell.
Patent BR-112013022761-B8 (BR)
Title: Compostos moduladores heterocíclicos de síntese de lipídios, suas composições e usos
Inventor: JOHAN D OSLOB
IPC: A61P35/00
Filed: 2012-03-08
Abstract: COMPOSTOS MODULADORES HETEROCÍCLICOS DE SÍNTESE DE LIPÍDIOS, SUAS COMPOSIÇÕES E USOS São fornecidos compostos que são moduladores de síntese de ácido graxo. Os compostos podem ser usados para tratar distúrbios caracterizados pela desregulação da função de sintase de ácido graxo por modulação da função e/ou da via de sintase de ácido graxo. Métodos são fornecidos para tratar tais distúrbios incluindo infecções virais, tais como infecção por hepatite C, câncer e distúrbios metabólicos
Patent BR-112014004920-B8 (BR)
Title: Decisões de filtro de desbloqueio de baixa complexidade
Inventor: MATTHIAS NARROSCHKE
IPC: H04N19/124
Filed: 2012-09-06
Abstract: DECISÕES DE FILTRO DE DESBLOQUEIO DE BAIXA COMPLEXIDADE. A presente invenção refere-se à filtragem de desbloqueio, que pode ser vantajosamente aplicada para a codificação e a decodificação em termos de bloco de imagens ou de sinais de vídeo. Em particular, a presente invenção refere-se a um gerenciamento de memória incrementado em uma decisão automatizada quanto ao fato se uma filtragem de desbloqueio para um bloco deve ser aplicada ou pulada e à seleção do filtro de desbloqueio. A decisão é tomada com base em uma segmentação de blocos de uma maneira tal que o uso da memória é otimizado. De preferência, a seleção de filtros de desbloqueio apropriados é incrementada de modo a reduzir as despesas de computação.
Patent BR-112014017348-B8 (BR)
Title: processo para produzir piche mesofásico de petróleo por hidrogenação de alcatrão de hulha à alta temperatura
Inventor: HONGMEI ZHAO
IPC: C10C3/08
Filed: 2012-04-06
Abstract: PROCESSO PARA PRODUZIR PICHE MESOFÁSICO DE PETRÓLEO POR HIDROGENAÇÃO DE ALCATRÃO DE HULHA À ALTA TEMPERATURA. Trata-se de um processo para produzir piche mesofásico de petróleo a partir de alcatrão de hulha à alta temperatura que compreende: remoção de sais e fração insolúvel de quinolina a partir de um alcatrão de hulha à alta temperatura para obter um óleo de decantação; usar o óleo de decantação como uma matéria prima de hidrogenação, ou pré-destilar o óleo de decantação para obter um resíduo com um ponto de ebulição maior do que 230ºC e formular o resíduo em uma matéria prima de hidrogenação; hidrorrefinar cataliticamente a matéria prima de hidrogenação para obter um óleo hidrorrefinado; destilar o óleo hidrorrefinado para obter piche de petróleo hidrogenado; e submeter o piche de petróleo hidrogenado à polimerização térmica para obter o piche mesofásico de petróleo. O processo tem recursos tais como um grau de hidrogenação facilmente controlável, remoção completa de impurezas, boa fluidez da matéria prima, não tendendo a formar a deposição de carbono e a coqueificação durante o processo, e não tendendo a obstruir o reator. O produto tem um alto conteúdo de piche mesofásico de petróleo, um ponto de amolecimento baixo e um baixo conteúdo de impurezas.
Patent BR-112018009522-B8 (BR)
Title: Seringa retrátil
Inventor: WALSH ALLAN
IPC: A61M5/32
Filed: 2016-11-18
Abstract: Uma seringa auto-retrátil tendo um tambor e um êmbolo, no qual o engatamento de referido êmbolo com um cubo de agulha, de outro modo, imobilizado, permite que um membro enviesante empurre o cubo de agulha em uma cavidade no êmbolo.
Patent EP-1114720-B9 (EP)
Inventor: STEPHAN GUENTER
IPC: B41F21/00
Filed: 2000-12-14
Granted: 2013-09-04
Abstract: Characteristic curves drawn using critical sheet conveyance parameters, plotted against optimal sheet parameter of specified printed are stored in memory. Actual specified sheet and printer specification data of print job are input to CPU. Based on the input data, CPU accesses optimum characteristic curve from the memory and outputs appropriate commands to individual actuators and allows operator intervention, if required. An Independent claim is also included for regulating and/or controlling device for air guide system.
Patent EP-0843515-B9 (EP)
Inventor: NARAYANAN KOLAZI S
IPC: A01N25/14
Filed: 1996-06-07
Granted: 2005-05-18
Abstract: A free-flowing, non-dusting water dispersible granule (WDG) of a water-insoluble, hydrophobic agriculturally active chemical having low friability and superior crush strength for delivery to a desired site as a stable, rainfast suspension in water, without foaming.
Patent EP-0807461-B9 (EP)
Inventor: MEISSNER WOLFGANG DR-ING
IPC: F26B11/04
Filed: 1997-05-09
Granted: 2002-09-11
Abstract: A non-rotating horizontal tubular reactor (1) for mechanical and/or thermal processing of a bulk solid or paste-form material has internal moving paddles (10) to convey and/or agitate the material in the presence of grinding or cleaning balls (15) inside the reactor chamber. The paddles (10) are mounted on a hollow shaft (7) passing axially through the reactor chamber (3). A conveying device, e.g. a screw conveyor (13), which acts in a direction opposite to that of the paddles (10), is provided inside the shaft to return the balls (15) from the outlet to the inlet end of the reactor.
Patent EA-038364-B9 (EA)
Title: Process for the production of biomass hydrolysate with reduced salt content
Inventor: ZAVREL MICHAEL
Filed: 2016-08-19
Abstract: The invention relates to a process for the production of biomass hydrolysate with reduced salt content.
Patent AU-2016393252-B9 (AU)
Title: Dynamic application execution for automobile and cloud hybrid environments
Inventor: SNYDER IRA
IPC: B60W20/50
Filed: 2016-12-21
Granted: 2021-02-04
Abstract: Embodiments are directed towards providing a dynamic application environment where separate components of an application can execute on separate processing hardware at any given point in time. A host device monitors current operating characteristics associated with a computing device, such a head unit of an automobile, and based on those characteristics selects which components of one or more applications to execute on the computing device and which components to execute on the host device, if any. The host device provides the selected components to the computing device for execution by the computing device and the host device executes any other components that are not executed by the computing device. The host device monitors the current operating characteristics associated with the computing device, and modifies the selection of which components are executing on which device based on changes in current operating characteristics.
Patent DE-3629992-C1 (DE)
Title: Tool grinding machine
Inventor: URBAN GUENTHER
IPC: B24B3/00
Filed: 1986-09-03
Granted: 1987-05-14
Abstract: In a tool grinding machine with T-shaped arrangement of the tool support table and of the grinding wheel support table, a grinding head housing is mounted on a vertical carriage so as to be rotatable about a horizontal axis, and to be precise by means of a rotational body. The grinding body housing encloses a spindle bearing sleeve substantially over its entire length. The grinding head housing is coarsely adjustable and lockable with respect to the rotational body by means of a sliding guide. Moreover, the grinding spindle bearing sleeve is finely adjustable with respect to the grinding head housing by means of a fine adjustment drive.
Patent DE-3638515-C1 (DE)
Inventor: FREIWALD GERHARD DIPL-ING
IPC: F16J15/3264
Filed: 1986-11-11
Granted: 1988-05-26
Abstract: A cassette shaft seal in which the outer ring (3) and the inner ring (11) have an opposite angular profile and together enclose an annular space (5) of substantially rectangular cross section. This annular space is bounded by an outwardly projecting flange (8) of the inner ring (11), which revolves together with the shaft that is to be sealed. The gap remaining between the flange (8) and the outside ring (3) is expanded in cross section by segmental cutouts uniformly distributed around the circumference, through which, under normal operating conditions, the volume of liquid contained in the annular space (5) is constantly renewed.
Patent DE-3714757-C1 (DE)
Title: Holder for a drawing pen
Inventor: HOFMANN HARALD
IPC: B43L13/02
Filed: 1987-05-02
Granted: 1988-02-25
Abstract: A holder (1) for a drawing pen (10) which can be moved in a drawing unit in a controlled manner relative to a drawing support, having a through aperture provided at the lower end for that part of the drawing pen (10) which possesses the tip (14), laterally supports the drawing pen (10) in the region above the through aperture, against spring pressure, such that it can be displaced radially relative to its central axis (15), and the drawing pen (10) is held in the region of the through aperture such that it can move in all directions about a point lying on its central axis (15). <IMAGE>