baber/WOPTO huggingface dataset:
Patent NO-874374-L (NO)
Inventor: BREIPOHL GERHARD
IPC: C07C271/00
Filed: 1987-10-20
Abstract: Compounds of the formula I <IMAGE>  in which A is hydrogen or an amino protective group, B is an amino acid residue, X is alkylene or aralkylene, Y<1>, Y<2>, Y<3> and Y<4> are identical or different and are hydrogen, methyl, methoxy or nitro, V is hydrogen or a carboxyl protective group, W is -[CH2]n- or -O-[CH2]n-, m is 0 or 1, n is 0 to 6 and p is 0 to 5, are prepared as described and used in the solid-phase synthesis.
Patent NO-880321-L (NO)
Title: Skinnespiker-inndrivingsmaskin.
Inventor: DIERINGER ANDREW M
IPC: E01B29/26
Filed: 1988-01-26
Abstract: En skinnespiker-inndrivingsmaskin (10) ned en ramme (20), hjul (22) og en spiker-inndrivingskanon (28) som kan forskyves parallelt med skinnen (18) og med styre-organer for begrensing av forskyvningen, omfatter et apparat for lesbart å låse kanonens (28) posisjon over en bestemt sville (14). Apparatet omfatter et telesko-perende rer med et innerelement (60) og et hult ytter-element (58). Innerelementet (60) er ved sin ene ende innført i ytterelementet (58) mens dets andre ende er festet til spiker-inndrivingskanonen.tterelementet (58) opptar innerelementet (60) ved sin ene ende og er forskyvbart festet til rammen () ved sin andre ende for å styre spiker-inndrivingskanonens (8) bevegelse vinkelrett på skinnen (8), og en utløsbar bremseanord-ning (7) er montert på ytterelementet (58) for å uteve en låsekfaft på innerelementet og hindre sidebevegelse av spikerkanonen.
Patent NO-884163-L (NO)
Inventor: GASBJERG KNUD
IPC: A01J25/11
Filed: 1988-09-20
Abstract: With the use of a distributor unit (4, 8), which is reciprocable over and along an oblong prepressing vat for cheese production, it has already been proposed that a uniform distribution of the whey/coagulum mixture can be achieved by means of horizontal wing rotors in a transverse distributor container (8), such rotor or rotors being rotated to lift the mixture up to an overflowing edge of the container while isolating the mixture from the turbulent mixture receiving area of the container. However, it is experienced that coagulum lumps may build up on the overflowing edge and thus disturb an even overflow. The invention provides for two interengaging wing rotors (22) mounted at the bottom of the container (8) so as to sluice down the mixture along opposite, correspondingly arched bottom/side portions (21) to a central lowermost outlet slot (20), whereby the risk of lump formations is practically eliminated without compromizing the desired uniform distribution of the coagulum.
Patent NO-885415-L (NO)
Inventor: TU CHIH-YUN JOHNNY
IPC: C07D241/08
Filed: 1988-12-06
Abstract: A process is described for preparing a compound of the formula (I)   <CHEM>  wherein R1 and R2 are individually selected from hydrogen and methyl or R1 and R2 together represent an ethylene bridge group.  A diamine of the formula (II)  H2N-CHR1-CHR2-NH2      (II) where R1 and R2 are defined as above is reacted with formaldehyde and an alkaline metal cyanide at a pH in the range of about 0 to 2 to produce a tetranitrile of the formula (III):  (NCCH2)2N-CHR1-CHR2-N(CH2CN)2      (III) This tetranitrile is hydrated to yield an acidic addition salt of a tetraamide of the formula (IV):  (H2NOCCH2)2N-CHR1-CHR2-N(CH2CONH2)2 .2HX      (IV) where R1 and R2 are defined as in formula (I) and X is an acid anion such as fluoride, chloride, bromide or sulphate but preferably chloride. The resultant acid addition salt is reacted in a cyclization reaction to yield the compound of formula (I).
Patent NO-893949-L (NO)
Inventor: HARRISON PHILIP GEOFFREY
IPC: B01D53/94
Filed: 1989-10-04
Abstract: Vehicle exhaust gas catalyst compositions are disclosed comprising SnO2, CrO3 and CuO, in the proportions SnO2:CrO3 weight ratio 99:1 to 1:99, CuO 0.5 to 100%, preferably 5 to 80%, based on the combined weight of SnO2 and CrO3.
Patent NO-903475-L (NO)
Inventor: MOGUILEWSKY MARTINE
IPC: C07J5/00
Filed: 1990-08-07
Abstract: Products of general formula (I): <IMAGE> in which R1 denotes an aliphatic hydrocarbon radical, R2 and R3, which are identical or different, denote a hydrogen atom or an alkyl radical, G denotes a hydrocarbon group containing from one to eighteen carbon atoms and optionally one or a number of identical or different heteroatoms, which is linked to the steroid nucleus by a carbon atom, and either X denotes XA, XA being a hydrogen atom, an alkyl radical, an arylalkyl radical or an acyl radical, and in this case Y denotes YA, YA being a group -B-O-CO-A-Z in which B denotes a saturated or unsaturated, linear or branched, divalent aliphatic radical, A denotes either a saturated or unsaturated, linear or branched, divalent aliphatic radical optionally interrupted or terminated by a divalent aromatic radical, or A denotes a divalent aromatic radical and Z denotes one of the functional groups -COOH or -SO3H, it being possible for these functional groups to be optionally converted into salt form or X denotes XB, XB being a group -CO-A-Z in which A and Z are as defined above and Y then denotes YB, YB being one of the groups chosen from -C IDENTICAL C-R4, -CH=CH-R4 or -CH2-CH2-R4, in which R4 denotes a hydrogen atom, a halogen atom, a trialkylsilyl radical, an alkyl radical or a phenyl radical, the said alkyl and phenyl radicals being optionally substituted.
Patent NO-904660-L (NO)
Inventor: MOTANI SHIGERU
IPC: C08J9/16
Filed: 1990-10-26
Abstract: The present invention concerns the following subjects:   (1) A process for producing a synthetic resin foam composed of cells having substantially two sizes, one of the sizes being at most 0.3 mm and the other size being 0.4 to 1 mm, comprising the steps of: forming a mixture of a water-absorbent high molecular compound, a cell controlling agent and a synthetic resin;        kneading and melting the mixture with heating; incorporating water together with a volatile-type foaming agent into the mixture under pressure; and extruding the mixture into a lower pressure space to form a foam.   (2) A process for producing a synthetic resin foam composed of cells having substantially two sizes, one of the sizes being at most 0.3 mm and the other size being 0.4 to 1 mm, comprising the steps of: forming a mixture of a water-absorbent high molecular compound, a cell controlling agent and a synthetic resin; adding water little by little to the mixture while or after mixing the mixture;        introducing the mixture into an extruder;        kneading and melting the resulting mixture with heating; incorporating a volatile-type foaming agent into the mixture under pressure; and extruding the mixture into a lower pressure space to form a foam.   (3) A process for producing a synthetic resin foam composed of cells having substantially two sizes, one of the sizes being at most 0.3 mm and the other size being 0.4 to 1 mm, comprising the steps of: forming a mixture of water, a cell controlling agent and a synthetic resin; adding a water-absorbent high molecular compound to the mixture and mixing them;        introducing the mixture into an extruder;        kneading and melting the mixture with heating; incorporating a volatile-type foaming agent into the mixture under pressure; and extruding the mixture into a lower pressure space to form a foam.   (4) A process for producing a synthetic resin foam composed of cells having substantially two sizes, one of the sizes being at most 0.3 mm and the other size being 0.4 to 1 mm, comprising the steps of:        forming a mixture of water a synthetic resin; adding a water-absorbent high polymer molecular compound and a cell controlling agent;        introducing the mixture into an extruder;        kneading and melting the mixture with heating; incorporating a volatile-type foaming agent into the mixture under pressure; and extruding the mixture into a lower pressure space to form a foam.     <IMAGE>
Patent NO-904806-L (NO)
Inventor: MARJARIAN WILLIAM ROBERT
IPC: C12R1/19
Filed: 1990-11-05
Abstract: The present invention is directed to recombinant genes and their encoded proteins which are recombinant flagellin fusion proteins. Such fusion proteins comprise amino acid sequences specifying an epitope encoded by a flagellin structural gene and an epitope of a heterologous organism which is immunogenic upon introduction of the fusion protein into a vertebrate host. The recombinant genes and proteins of the present invention can be used in vaccine formulations, to provide protection against infection by the heterologous organism, or to provide protection against conditions or disorders caused by an antigen of the organism. In a specific embodiment, attenuated invasive bacteria expressing the recombinant flagellin genes of the invention can be used in live vaccine formulations. The invention is illustrated by way of examples in which epitopes of malaria circumsporozoite antigens, the B subunit of Cholera toxin, surface and presurface antigens of Hepatitis B, VP7 polypeptide of rotavirus, envelope glycoprotein of HIV, and M protein of Streptococcus, are expressed in recombinant flagellin fusion proteins which assemble into functional flagella, and which provoke an immune response directed against the heterologous epitope, in a vertebrate host.
Patent NO-904946-L (NO)
Inventor: PESCHER YVETTE
IPC: C22B3/26
Filed: 1990-11-14
Abstract: Process for the recovery of gallium from a basic solution such as the Bayer lye. 
<??>This process consists in extracting the gallium present in Bayer lye into a water-immiscible solvent and in then reextracting the gallium with a strong base solution. 
<??>In a second cycle the gallium present in the strong base solution is reextracted with a water-immiscible solvent and then recovered with an aqueous solution which is either acidic or basic, to produce a gallium solution which can be subjected directly to an electrolysis with a view to the production of gallium metal.
Patent NO-905018-L (NO)
Inventor: LARRECQ MICHEL
IPC: B22D11/10
Filed: 1990-11-20
Abstract: Device for continuous casting of thin metal strips (6) between two parallel rotating rolls (2), comprising lateral faces at the ends of the rolls defining, with the rolls, the casting space for the molten metal (1), characterised in that it comprises a flat cover (7), arranged above the molten metal (1) and in the immediate vicinity of its meniscus in order to form a thermal screen which is of a size so as to cover over the entire surface of the molten metal, this cover (7) being provided with a refractory coating (8) on its face which is turned towards the molten metal and bearing on the two rolls (2). This cover forms a thermal shield or screen preventing any incipient surface solidification of the bath of molten metal (1). Advantageously, an inert gas may be injected between the meniscus (4) and the cover (7) through the latter. 
<IMAGE>
Patent NO-913344-L (NO)
Inventor: ENGSTROEM JOERGEN
IPC: D21C9/14
Filed: 1991-08-26
Abstract: A process for the production of chlorine dioxide by reacting in a reaction vessel an alkali metal chlorate, mineral acid and a reducing agent in such proportions that chlorine dioxide is produced in a reaction medium which is maintained at a temperature of from about 50 DEG C to about 100  DEG C and at an acidity within a range of from about 5 N to about 11 N. The reaction medium is subjected to subatmospheric pressure sufficient for evaporating water, a mixture of chlorine dioxide, oxygen and water vapour being withdrawn from an evaporation zone in the reaction vessel, and alkali metal sulfate being precipitated in a crystallization zone in the reaction vessel. As the reducing agent hydrogen peroxide is used.
Patent NO-921253-L (NO)
Title: Sementeringsanordning
Inventor: COONE MALCOLM G
IPC: E21B/
Filed: 1992-03-31
Abstract: Det er beskrevet en anordning til bruk ved Innføring av sement l rlngrommet mellom en forlngsstreng (9) og en brønnboring der forlngsstrengen (9) er opphengt, og anordningen omfatter en trlnnmansjett (11, 12, 13) som kan Innkobles som en del av forlngsstrengen (9) og har en omgivende paknlngsdel (18) som er beregnet på å bil ekspandert til anlegg mot brønnboringen, en eller flere sldeporter (14) gjennom hvilke sement kan Innføres l rlngrommet over pakningen (18) og rørformede deler eller hylser (30) for åpning og lukking av portene (14) etter ekspansjon av paknlngsdelen (18).
Patent NO-923484-L (NO)
Inventor: KOIKE HIROYUKI
IPC: C07D495/04
Filed: 1992-09-08
Abstract: Hydropyridine derivs. of formula (I) and their tautomers and their salts are new. In (I), R1 = H, 1-4C alkyl, halo, 1-4C haloalkyl, OH, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C haloalkylthio, amino, 1-5C alkanoyl, 2-5C haloalkanoyl, COOH, 2-5C alkoxycarbonyl, carbamoyl, CN, NO2, 1-4C alkanesulphonyl, 1-4C haloalkanesulphonyl or sulphamoyl; R2 = 1-10C alkanoyl, 2-10C alkanoyl substd. by at least one A, 3-6C alkenoyl opt. substd. by at least one A, 4-8C cycloalkylcarbonyl opt. substd. by at least one A, benzoyl substd. by at least one B or 5,6-dihydro-1,4,2-dioxazin-3-yl; R3 = H, OH, 1-4C alkoxy opt. substd. by at least one C, aralkyloxy, 1-18C alkanoyl, 3-6C alkenoyl, 4-8C cycloalkylcarbonoxy, arylcarbonyloxy, phthalidyloxy, (5-methyl-2-oxo -1,3-dioxolen-4-yl) methoxy, (5-phenyl-2-oxo-1,3 -dioxolen-4-yl)-methoxy, NRaRb, aralkylamino, 1-18C alkanoylamino, 3-6C alkenoylamino, 4-8C cycloalkylcarbonylamino, arylcarbonylamino, 2-5C alkoxycarbonylamino, aralkyloxycarbonylamino, phthalidylamino, (5-methyl-2-oxo -1,3-dioxolen-4-yl) methylamino, (5-phenyl-2-oxo-1,3 -dioxolen-4-yl) methylamino or NO2; Ra,Rb = H or 1-4C alkyl opt. substd. by at least one C; Y = NH, O or S; n = 1-5; A = halo, OH, 1-4C alkoxy or CN; B = 1-4C alkyl, halo or 1-4C alkoxy; C = 1-4C alkoxy, 1-6C alkanoyloxy or arylcarbonyloxy; alkyl contain 1-4C; aryl have 6-10C in a carbocyclic ring opt. substd. by at least one D; D = as R' except H.
Patent NO-930065-L (NO)
Inventor: CRACKNELL ROBERT BRIAN
IPC: C08G65/327
Filed: 1993-01-08
Abstract: A polyalkylene glycol ether phosphate ester, or salt thereof, having the formula:    Rw-P(O)(OH)3-w   (I>  wherein w is an integer from 1 to 3, and     R is an oil-soluble polyether moiety having the formula:    R<1>X[(CxH2xO)n(CyH2yO)p]m   (II> wherein R<1> is either an alkyl or an alkyl phenyl group having from 7 to 30 carbon atoms,     X is either O, S, or N     x is an integer from 2 to 4,     y is an integer from 6 to 30,     m is 1 when X is O or S and m is 2 when X is N, n and p are such that the polyether moiety contains between 1 and 35% by weight of (CyH2yO) units and between 35 and 80% by weight of (CxH2xO) units, and the molecular weight of the polyalkylene glycol moiety is between 500 and 5000 is disclosed. The phosphate ester can be prepared by reacting a polyether with a phosphating agent, e.g. phosphorus pentoxide and water. Lubricating oil compositions comprising the phosphate ester or salt thereof are also disclosed. The phosphate esters and salts thereof are useful as extreme pressure/anti-wear additives.
Patent NO-931095-L (NO)
Title: Stabilisering av peroksydblekevaesker med klordioksyd
Inventor: JONES TREVOR ERIC
IPC: D21C9/16
Filed: 1993-03-24
Abstract: Klordioksyd anvendes for å stabilisere hydrogenperoksyd i blekevæske ved alkalisk pH. Dette antas å hjelpes ved ødeleggelse av enzymer (spesielt katalase) som produseres av bakterier. Metoden er nyttig for reprosesserlng av masser, spesielt når et avfargings- trinn er involvert.
Patent NO-933254-L (NO)
Inventor: DUPUY BERNARD
IPC: H04B7/26
Filed: 1993-09-13
Abstract: The mobile telephone time advance system hands over from a first base station (BTS1) to a second base station (BTS2) when coverage in the first base area is lost. A mobile telephone (MS) time division multiplexes information, and when a handover command is received a predetermined time advance (TA-BTS2) from the second station is applied reducing the handover time when signals are not received.
Patent NO-950641-L (NO)
Inventor: LEITHE VIGDIS MARIE
IPC: A61F13/06
Filed: 1995-02-21
Abstract: Massage and relief bandage device for persons vulnerable to bedsores (decuibitus ulcer), having a bag device of a flexible material, particularly cloth, which is filled with foamed plastic beads. The cloth material is a porous material, permeable to air, and the bag device has a plurality of chambers divided by non-filled parts that extend to the edges of the bandage device. The amount of filling material in the chambers is low to allow displacement of the granular material without particular outside pressure.
Patent NO-950870-L (NO)
Title: Fremgangsmåte ved containertransport og integrert system for slik transport
Inventor: MYRVOLD PER
IPC: B63B27/00
Filed: 1995-03-07
Abstract: Ved containertransport innbefattende land- og sjøtransport av containere av standardtype under utnyttelse av omlastingsområder hvor containerne avstilles fra og hentes av henholdsvis landkjøretøy og sjøfartøy, bringes containerne til og hentes på et omlastings- område av/med dertil egnede landkjøretøy, plasseres i separate rader der ved hjelp av containertransport- organer som strekker seg under hver containerrad og samvirker med undersiden av den enkelte, overliggende container. Fra omlastingsområdet lastes de ombord i et sjøfartøy ved hjelp av overliggende løfte-forflytnings- transportorganer i overgangen mellom omlastingsområdet og skipet og omvendt, idet de fra den enkelte rad bringes frem til en stilling ved en fartøyside, der forflyttes over på en elevator ombord l fartøyet, med elevatoren forflyttes til i høyde med et i fartøyets lengderetning forløpende containertransportorgan som strekker seg under hver rad og samvirker med undersiden av den enkelte overliggende container, med disse bringes til ønsket stilling ombord, i langsgående, i fartøyets høyde og bredde separate rader, med fartøyet bringes til ønsket lossehavn og der losses i omvendt sekvens, idet de herunder bringes til et omlastirtgs- område og der overtas av landkjøretøy. Containerne lastes/losses gjennom en sideport i fartøyet.
Patent NO-953557-L (NO)
Inventor: GRUNDEY GERALD BURR
IPC: A61P35/00
Filed: 1995-09-08
Abstract: This invention provides certain indolinesulfonamide and substituted-indolesulfonamide derivatives of the formula <CHEM>  wherein: <CHEM>  R<1> is C1-C6 alkyl; R<2> and R<3> are independently selected from the group consisting of hydrogen, halo, C1-C6 alkyl, and trifluoromethyl, provided that no more than one of R<2> and R<3> can be hydrogen; and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these indolinesulfonamide and substituted-indolesulfonamide derivatives in combination with a carrier, excipient or diluent, as well as processes for preparing the compounds.
Patent NO-954314-L (NO)
Inventor: SAKSENA ANIL K
IPC: C07D521/00
Filed: 1995-10-27
Abstract: Disclosed is a process for preparing chiral compounds of the formula (I)    <IMAGE>  (I)  wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula   <IMAGE>   or   <IMAGE>   wherein: X1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2OR''; Q* represents a chiral auxiliary group; R'' represents a hydroxy protecting group selected from -CH2C6H5, or -C(O)R1, wherein R1 is C1-C6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.
Patent NO-955224-L (NO)
Title: N-cyanometylerte kitosaner og hydrolysater derav
Inventor: HAASE JURG
IPC: A61K8/36
Filed: 1995-12-21
Abstract: N-cyanometylert kitosaner av formelen: hvor nj er fra 0,6, fortrinnsvis fra 0,05 til 0,20; n2 er fra O til 0,20, fortrinnsvis fra 0,05 til 0,10; 013+114) er fra 0,4 til l ,0, fortrinnsvis fra 0,8 til 0,95, og hydrolysatene derav av formelen: H r Ac NH, OH hvor -J(13 M-CH,COO' CHjCOO" nj er fra O til 0,6, fortrinnsvis fra 0,05 til 0,20; n2 er fra 0,01 til 0,20, fortrinnsvis fra 0,05 til 0,10; (113+114) er fra 0,4 til 1,0, fortrinnsvis fra 0,8 til 0,95, samt fremgangsmåter for fremstilling av disse forbindelsene. De cyanometylerte kitosanene, spesielt hydrolysatene som tilsvarer formel (2), har allsidig nyttevirkning som separeringsmembraner, kompleksdannende midler, belegginhibitorer, stabilisatorer for blekevæsker, fuktighetsbevarende midler i kosmetiske preparater, fortykningsmidler og avstøtningsmidler.
Patent NO-964549-L (NO)
Title: Anvendelse av et termostabilt enzym som for-tilsetning, samt for hvor dette inngår
Inventor: MORGAN ANDREW JOHN
IPC: C12R1/645
Filed: 1996-10-25
Abstract: Termostabil xylanase som tilsetnings- stoff for dyreffir, hvor xylanasen er i stand til å tolerere oppvarming i ett minutt i vannbad innstilt på 95 "C uten vesentlig tap av aktivitet. En slik xylanase kan oppnås fra Microtetraspora flexuosa eller Thermomonospora fusca. Det tilveiebringes også en fortilsetning innbefattende en slik termostabil xylan- ase i kombinasjon med en fysiologisk akseptabel bærer som kan være et cereal eller være cerealbasert. Et cerealbasert for innbefatter minst 20 vekt% cereal og 0,00001-10 g termostabilt xylanasepro- i tein pr. kg f6r. Cerealet kan være hvil- ] ket som helst av hvete, bygg, mais, l sorghum, rug, havre, tritikal og ris. j Det cerealbaserte for kan gis til all ' buskap, og særlig til fjærfe og griser.
Patent NO-971687-L (NO)
Inventor: PASCAL YVES
IPC: A61K31/55
Filed: 1997-04-11
Abstract: The invention relates to diazepinoindoles of formula:   <IMAGE>   in which R is hydrogen, lower alkyl or lower alkoxy; A is aryl or nitrogen-containing heteroaryl, each of which is optionally substituted by from one to three groups of halogen, lower alkyl, haloalkyl, lower alkoxy and acetamido, or their racemic forms, isomers or pharmaceutically acceptable salts, wherein for the racemic forms of the (S) configuration, A is not phenyl, haloalkyl, or 2-indolyl when R is hydrogen, and for the racemic forms of the (R) configuration, A is not 2-indolyl when R is hydrogen. Also, the invention relates to a method for inhibiting cyclic nucleotide phosphodiesterase activity by administering these compounds to a subject in an amount which is therapeutically effective to inhibit cyclic nucleotide phosphodiesterase activity.
Patent NO-971886-L (NO)
Inventor: LAAS HANS-JOSEF
IPC: C09D175/04
Filed: 1997-04-24
Abstract: Polyurethane powder lacquer contains (A) a binder component with a hydroxyl (OH) number of 25-200 and an average molecular weight of 400-10000 (calculated from the functionality and OH content), which is solid below 40 degrees C and liquid above 130 degrees C; (B) a polyaddition component containing uretdione groups and optionally free isocyanate (NCO) groups based on aliphatic and/or cycloaliphatic diisocyanates, which is solid below 40 degrees C and liquid above 125 degrees C; (C) catalyst containing N,N,N'-tri-substituted amidine structures, which contains 12.0-47.0 wt.% amidine (CN2) groups; optionally (D) other known catalysts; and optionally (E) other usual ancillaries and additives. The mixture contains 0.6-1.4 dimeric NCO (uretdione) and free NCO groups in (B) per OH group in (A) and the amount of (C) is 0.05-5 wt.% of the total amounts of components (A) to (E).
Patent NO-972190-L (NO)
Inventor: YAMAMOTO KENJIRO
IPC: C07D403/14
Filed: 1997-05-13
Abstract: Crystals of 3-Ä2-Ä4-(3-chloro-2-methylphenyl)-1-piperazinylÜethylÜ-5,6-dimethoxy-1 -(4-imidazolylmethyl)-1H-indazole dihydrochloride which is a hydrate for pharmaceutical use having excellent characteristics as a pharmaceutical material that has high storage stability and which substantially has specified X-ray diffraction characteristics, more particularly, the dihydrochloride is 3.5-hydrate.