Patent SG-11201805521X-A (SG)
Title: Method for quantification of purity of sub-visible particle samples
Inventor: SINTORN IDA-MARIA
IPC: C12Q1/70
Filed: 2017-09-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/063785 Al 05 April 2018 (05.04.2018) WIP0 I PCT (51) International Patent Classification: gen 16, S-141 68 Huddinge (SE). KYLBERG, Gustaf; Lil- BOlD 11/00 (2006.01) C12Q 1/70 (2006.01) lies vag 7, S-192 74 Sollentuna (SE). NILSSON, Josefina; (21) International Application Number: August Plyms vag 12, S-133 33 Saltsjobaden (SE). PCT/US2017/050962 (74) Agent: FASTH, Rolf; Fasth Law Offices, 1206 Stanridge Drive, Raleigh, North Carolina 27613 (US). (22) International Filing Date: 11 September 2017 (11.09.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/402,003 30 September 2016 (30.09.2016) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant: INTELLIGENT VIRUS IMAGING INC. MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [US/US]; 26 Pinecrest Plaza, Suite 2, Southern Pines, North OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Carolina 28387 (US). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: SINTORN, Ida-Maria; Poppelvagen 11B, S-191 41 Sollentuna (SE). RYNER, Martin; Glasbarsva- Title: METHOD FOR QUANTIFICATION OF PURITY OF SUB-VISIBLE PARTICLE SAMPLES (54) Fig 7. 120 \ , ' 102 i 106 1-1 G i n (57) : The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image (100) of the sample. The sample contains objects (114). The objects (114) that M have sizes being different from a size range of primary particles (120) and sizes being within the size range of primary particles (120) are enhanced. The objects (114) are detected as being primary particles (120) or debris (106). The detected primary particles (120) are --.... excluded from the objects (114) so that the objects (114) contain debris (106) but no primary particles (120). A first total area (T1) of X Il ) the detected debris (106) is measured. A second total area (T2) of the detected primary particles (120) is measured. 0 ei O [Continued on next page] WO 2018/063785 Al MIDEDIMOMOIDEIRDERIONIMOINOMMOMEMON (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))