Patent SG-11201900561X-A (SG)
Title: Chemokine receptor modulators and uses thereof
Inventor: BECK HILARY
IPC: C07D401/12
Filed: 2017-07-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) W I P0 I P C T omit 01110011010II 111110lII ow (10) International Publication Number WO 2018/022992 Al (51) International Patent Classification: A61K 31/5377 (2006.01) C07D 401/12 (2006.01) (21) International Application Number: PCT/US2017/044369 (22) International Filing Date: 28 July 2017 (28.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/368,848 29 July 2016 (29.07.2016) US 62/426,087 23 November 2016 (23.11.2016) US (71) Applicant: FLX BIO, INC. [US/US]; 561 Eccles Avenue, South San Francisco, CA 94080 (US). (72) Inventors: BECK, Hilary, Plake; 115 Springdale Way, Emerald Hills, CA 94062 (US). BIANNIC, Berenger; 1600 E 3rd Avenue, Apt 2508, San Mateo, CA 94401 (US). BUI, Minna Hue, Thanh; 2445 25th Avenue, Oakland, CA 94601 (US). HU, Dennis, X.; 3014 Los Prados, Apt. 103, San Mateo, CA 94403 (US). KETCHAM, John, Michael; 817 N. Humboldt Street, Apt. 211, San Mateo, CA 94401 (US). POWERS, Jay, Patrick; 745 Rockaway Beach Avenue, Pacifica, CA 94044 (US). REILLY, Mau- reen, Kay; 85 Richland Avenue, Unit 5, San Francisco, CA 94110 (US). ROBLES-RESENDIZ, Omar; 1 Avocet Drive, Apt. 206, Redwood City, CA 94065 (US). SHUNA- TONA, Hunter, Paul; 79 Melrose Avenue, San Francisco, CA 94131 (US). WALKER, James, Ross; 9326 Ancient Oak Lane, Verona, WI 53593 (US). WUSTROW, David, Juergen; 116 Vallecitos Way, Los Gatos, CA 95032 (US). YOUNAI, Ashkaan; 397 Imperial Way, Apt. 143, Daly City, CA 94015 (US). ZIBINSKY, Mikhail; 1582 Hudson Street, Redwood City, CA 94061 (US). (74) Agent: YVON, Brigitte, L. et al.; Mintz Levin Cohn Fer- ris Glovsky and Popeo, P.C., One Financial Center, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 1-1 O \" (57) : Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity. (54) Title: CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF C