Patent SG-11201901146S-A (SG)
Title: Indazole compounds for use in tendon and/or ligament injuries
Inventor: BURSULAYA BADRY
IPC: C07D231/56
Filed: 2017-09-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 March 2018 (29.03.2018) WIPO I PCT (10) International Publication Number WO 2018/055550 A1 (51) International Patent Classification: C07D 231/56 (2006.01) A61K31/416 (2006.01) A61P19/04 {2006.01) (21) International Application Number: PCT/IB2017/055735 (22) International Filing Date: 21 September 2017 (21.09.2017) (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/398,869 23 September 2016 (23.09.2016) US (74) Agent: NOVARTIS AG; (CH). Lichtstrasse 35, 4056 Basel English English (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). (72) Inventors: BURSULAYA, Badry; Novartis Institute for Functional Genomics, Inc., dba Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hop­ kins Drive, San Diego, California, California 92121 (US). FISCH, Andreas; Novartis Pharma AG, Postfach, 4002 Basel (CH). LAJINESS, James Paul; Novartis Institute for Functional Genomics, Inc., dba Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hop­ kins Drive, San Diego, California, California 92121 (US). MACHAUER, Rainer; Novartis Pharma AG, NIBR Kly- beck, Postfach, 4002 Basel (CH). MALEKAR, Swap- nil; Novartis Institutes for BioMedical Research, Inc., Emeryville Site 5300 Chiron Way, Bldg. 4, Emeryville, Cal­ ifornia 94608 (US). PETRASSI, Hank Michael James; 4695 Serenata Place, San Diego, San Diego, California 92130 (US). RAMAZANI, Farshad; Novartis Pharma AG, Postfach, 4002 Basel (CH). REMOND, Anne-Cather­ ine; Novartis Pharma AG, Novartis Institutes for Bio- med. Research, Postfach, 4002 Basel (CH). ULLRICH, Thomas; Novartis Pharma AG, Novartis Institutes for Bio- med. Research, Postfach, 4002 Basel (CH). USSELMANN, Peggy; Novartis Pharma AG, Novartis Institutes for Bio- med. Research, Postfach, 4002 Basel (CH). VANGREV- ELINGHE, Eric; Novartis Pharma AG, Novartis Institutes for Biomed. Research, Postfach, 4002 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES o © 00 i-H o CJ H?N J R- JL NR3R4 -S02 \ (R2)n (I) (57) : The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a com­ bination of pharmacologically active agents and a pharmaceutical composition.