Patent SG-11201808882Q-A (SG)
Title: Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
Inventor: SHORT JAY
IPC: G01N33/574
Filed: 2017-05-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/197234 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, C07K 16/28 (2006.01) G01N 33/574 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, A61K 47/50 (2017.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (21) International Application Number: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, PCT/US2017/032357 TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 12 May 2017 (12.05.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (25) Filing Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (26) Publication Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (30) Priority Data: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 62/335,719 13 May 2016 (13.05.2016) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 62/447,218 17 January 2017 (17.01.2017) US KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BIOATLA, LLC [US/US]; 11011 Torreyana Declarations under Rule 4.17: Road, San Diego, CA 92121 (US). — of inventorship (Rule 4.17(iv)) (72) Inventors: SHORT, Jay, M.; 12985 Via Esperia, Del Mar, Published: California 92014 (US). CHANG, Hwai, Wen; 1318 Shad- ow Hills Drive, San Marcos, — with international search report (Art. 21(3)) California 92069 (US). FREY, — with sequence listing part of description (Rule 5.2(a)) Bella, San Diego, California Gerhard; 13768 Via Cima 92129 (US). Kevin, J. et al.; Mendelsohn Dun- (74) Agent: DUNLEAVY, F. Kennedy Blvd., Suite 312, leavy, P.C., 1500 John Philadelphia, Pennsylvania 19102 (US). otherwise indicated, for every (81) Designated States (unless available): AE, AG, AL, AM, kind of national protection BG, BH, BN, BR, BW, BY, BZ, AO, AT, AU, AZ, BA, BB, CU, CZ, DE, DJ, DK, DM, DO, CA, CH, CL, CN, CO, CR, GB, GD, GE, GH, GM, GT, HN, DZ, EC, EE, EG, ES, FI, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, Title: ANTI-ROR2 ANTIBODIES, (54) ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOF , ...., - Ak,, i,L4,,', D main fat r Donia-i Extracelkita 1-1 7r M N IN 01 FIG. 1 1-1 IN C (57) : A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Ror2 N protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region — that bind to Ror2 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments ..) containing the polypeptide are also provided