Patent CA-2223237-A1 (CA)
Title: 1-phenyl-pyrazole derivatives and their use as parasiticidal agents
Inventor: BANKS BERNARD JOSEPH
IPC: A61K31/427
Filed: 1997-11-28
Abstract: Compounds of formula (I),   wherein R1 is H, C1-6 alkyl optionally substituted by one or more halogen atoms, halogen, CN,C1-6 alkoxycarbonyl optionally substituted by one or more halogen atoms, NO2, CHO, CONH2, CSNH2 or C1-6 alkanoyl optionally substituted by one or more halogen atoms; Ar is a ring "A" where "A" is a phenyl group, or "A" is a 5- or 6-membered heteroaryl group, wherein heteroaryl means a fully unsaturated heterocycle, containing 1,2 or 3 hetero-atoms, which heteroatoms are independently selected from 1 N atom, 1 or 2 O atoms and 1 or 2 S atoms, where the valence allows, or Ar is a fused bicyclic moiety "AB" where the "A" ring is as defined above and the "B" ring fused thereto in "AB" is a 5- or 6-membered saturated or partially or fullyunsaturated carbocycle, or saturated or partially or fully unsaturated heterocycle where the valence allows, which heterocycle contains 1,2,3 or 4 heteroatoms independently selected from 1,2,3 or 4 N atoms, 1 or 2 O atoms and 1 or 2 S atoms, where the valence allows, said Ar group being linked via the "A" ring to the 4-position of the pyrazole via a carbon-carbon bond, and said Ar group being optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl optionally substituted by one or more halogen atoms, C1-6 alkoxy optionally substituted by one or more halogen atoms, C1-6 alkoxycarbonyl optionally substituted by one or more halogen atoms, NO2, NH2, CN or S(O)m(C1-6 alkyl optionally substituted by one or more halogen atoms);     R2 is H, halogen, C1-6 alkyl optionally substituted by one or more halogen atoms, C2-6 alkenyl optionally substituted by one or more halogen atoms, C2-6 alkynyl optionally substituted by one or more halogen atoms, NH2,NH(C1-6 alkanoyl optionally substituted by one or more halogen atoms), NH(C1-6 alkoxycarbonyl optionally substituted by one or more halogen atoms), N(C1-6 alkoxycarbonyl optionally substituted by one or more halogen atoms)2, NH(C1-6 alkyl optionally substituted by one or more halogen atoms), N(C1-6 alkyl optionally substituted by one or more halogen atoms)2, NHCONH(C1-6 alkyl optionally substituted by one or more halogen atoms), N-pyrrolyl, NHCONH(phenyl optionally substituted by one or more halogen atoms), N=CH(phenyl optionally substituted by one or more halogen atoms), OH,C1-6 alkoxy optionally substituted by one or more halogen atoms, SH or S(O)m(C1-6 alkyl optionally substituted by one or more halogen atoms); R3,R4,R5,R6 and R7 are each independently H, halogen, nitro, C1-6 alkoxycarbonyloptionally substituted by one or more halogen atoms, C1-6 alkyl optionally substituted by one or more halogen atoms, CN, C1-6 alkanoyl optionally substituted by one or more halogen atoms, CONH2, CSNH2, C1-6 alkoxy optionally substituted by one or more halogen atoms, S(O)m(C1-6 alkyl optionally substituted by one or more halogen atoms) or SF5; m is 0,1 or 2; with the proviso that when R1 is H or C1-6 alkyl, and R2 is H, halogen, NH2, NH(C1-6 alkanoyl), NH(C1-6 alkoxycarbonyl), N(C1-6 alkoxycarbonyl)2, NH(C1-6 alkyl), NHCONH(C1-6 alkyl), or NHCONH(phenyl optionally substituted by halogen), then Ar is not a non-fused heteroaryl group; or pharmaceutically- or veterinarily-acceptable salts thereof, are new. Such compounds and salts, without proviso, have useful parasiticidal qualities.