baber/WOPTO huggingface dataset:
Patent BR-0316865-A (BR)
Title: Variante de butirilcolinesterase, ácido nucleico, e, métodos para converter um derivado de camptotecina a um inibidor de topoisomerase, e para tratar câncer
Inventor: WATKINS JEFFRY D
IPC: A61K38/00
Filed: 2003-12-04
Abstract: "VARIANTE DE BUTIRILCOLINESTERASE, áCIDO NUCLEICO, E, MéTODOS PAPA CONVERTER UM DERIVADO DE CAMPTOTECINA A UM IMBIDOR DE TOPOISOMERASE E PARA TRATAR CâNCER". A invenção proporciona uma variante de butirilquinesterase apresentando a seq³ência de aminoácidos selecionadas das SEQ ID NOS: 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 69, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194 e 196, ou seu fragmento funcional. Adicionalmente, a invenção proporciona um método para converter um derivado de camptotecina a um inibidor de topoisomerase mediante o contato do derivado de camptotecina com uma variante de butirilcolinesterase selecionada das SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 1242 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 548, 150, 152, 154, 156, 1585 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, e 196, ou seu fragmento funcional, em condições que permitem conversão de um derivado de camptotecina a um inibidor de topoisomerase. Adicionalmente, a invenção proporciona um método para tratar câncer mediante a administração a um indivíduo de uma quantidade individual e efetiva de uma variante de butirilcolinesterase selecionada de SEQ ID NO 2, 4, 6, 8, 10, 12, 14, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, e 196, ou seu fragmento funcional, apresentando capacidade aumentada de converter um derivado de camptotecina a um inibidor de topoisomerase em comparação com butirilcolinesterase.
Patent BR-0317780-A (BR)
Title: Formulação na forma de supositório para a administração retal, método para o tratamento de hemorróidas, e uso de peptìdeos e proteìnas com ação trombolìtica para o tratamento de hemorróidas
Inventor: MIRAGAYA MARIA ACELIA MARRERO
IPC: A61K38/16
Filed: 2003-12-22
Abstract: "FORMULAçãO NA FORMA DE SUPOSITóRIO PARA A ADMINISTRAçãO RETAL, MéTODO PARA O TRATAMENTO DE HEMORRóIDAS, E USO DE PEPTìDEOS E PROTEìNAS COM AçãO TROMBOLìTICA PARA O TRATAMENTO DE HEMORRóIDAS". Formulações farmacêuticas em forma de supositórios que contém agentes com ação trombolítica capazes de penetrar na mucosa retal para o tratamento da enfermidade hemorroidal aguda e/ou de origem trombótica.
Patent BR-8108861-A (BR)
Inventor: SCHLATTER WALTER
IPC: B21K1/06
Filed: 1981-11-06
Abstract: Within the spindles made of several parts (1, 2) assembled for the construction of machines, engines and gear boxes, there is provided within the spindle a sealed chamber (4, 5) which is symmetrical in rotation. Parts (1, 2) are obtained through creep extrusion and welded together approximately in their radial plane. This bond may be achieved by means of friction welding, electron bombardment welding, arc welding, shrink ring fitting, force fitting or caulking. The lightening and the facilitation of the manufacture as well as the strength of the spindles are thereby achieved, in particular for the spindles having extremities with decreasing diameters and for which conventional processes produce a considerable amount of worthless turning chips or similar.
Patent BR-8202812-A (BR)
Inventor: PEZZOLLI NELLO
IPC: D03D47/20
Filed: 1982-05-14
Abstract: In a drawing gripper for shuttleless looms, of the type comprising a fixed member (1) with a hook end (2) and a mobile oscillating element (3), the end of which cooperates with said hook in order to retain the weft yarn, said hook extends in a vertical plane and opens downwards. A vertical fin (6) is also provided on the fixed member to act as a yarn protection element.
Patent BR-8207499-A (BR)
Inventor: REUTER HERBERT
IPC: C11D1/12
Filed: 1982-12-27
Abstract: Process for reducing the viscosity of aqueous concentrates of anionic surfactants by adding thereto a small quantity of a compound containing polyglycol ether groups; and the aqueous concentrates prepared thereby.
Patent BR-8406606-A (BR)
Inventor: BREWERTON ROBERT WALTER
IPC: B63B35/44
Filed: 1984-12-20
Abstract: A compensator for providing resilience in a connection between relatively moveable objects comprises a piston (3) working in a cylinder (2) which is surrounded by a larger coaxial cylinder (1) joined thereto by annular wall members (1a) thus defining about the cylinder (2) a pair of annular reservoirs (8, 9,) The piston (3) divides the cylinder (2) into a pair of chambers (6, 7), chamber (6) being connected by conduit (12) to reservoir (9) and chamber (7) being connected by conduit (10) to reservoir (8). Each reservoir contains a mixture of liquid and gas whilst the chambers contain liquid. Elongation of the connection between the objects causes withdrawal of the piston (3) with consequent expansion of the volume of gas in reservoir (9) against atmospheric pressure and against pressure developed in reservoir (8) as a consequence of decrease of gas volume therein.
Patent BR-8507219-A (BR)
Inventor: SIBALIS DAN
IPC: A61N1/30
Filed: 1985-06-10
Abstract: A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin, with the applicator (100) removably connected to the mounting structure (138,140). A power supply for the applicator (100) and a circuit transmitting electrical power from the power supply to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin. The device includes a computer with the mounting structure(138,140) for receiving programmed instructions relative to the drug, and transmitting signals relative to the drug and the programmed instructions to the power supply for regulating the generation of power and delievery of drug through the skin. <IMAGE>
Patent BR-8700916-A (BR)
Inventor: GIERENZ GERHARD
IPC: C09J4/00
Filed: 1987-02-26
Abstract: A soft-rubbing shaped adhesive is based on an adhesive forming polymer solution gelled with a soap-forming gelling agent in the presence of a modifying additive comprising an aminocarboxylic acid or corresponding lactam, preferably an aminocarboxylic acid containing from 4 to 8 carbon atoms. Especially useful modifying additives include caprolactam, the sodium salt of aminocaproic acid, or a mixture thereof.
Patent BR-8701933-A (BR)
Inventor: TOBLER HANS
IPC: C07C317/18
Filed: 1987-04-23
Abstract: 1. A novel 2-acyl-1,3-cyclohexanedione, or an oxime ether thereof, of formula I   see diagramm : EP0243313,P35,F4   wherein A is a 2- to 7-membered alkylene bridge, or a 3- to 7-membered alkenylene bridge which may be mono- or polyunsaturated n is zero, one or two, R1 is C1 -C4 alkyl or benzyl, R2 is C1 -C6 alkyl which is unsubstituted or substituted by halogen, C1 -C4 alkoxy or C1 -C4 alkylthio ; or is C3 -C6 cycloalkyl ; or phenyl, benzyl or phenylethyl, the phenyl ring of each of which may be substituted by halogen, C1 -C4 haloalkoxy, cyano or nitro, X is oxygen or a radical -NOR3 , and R3 is C1 -C6 alkyl, C1 -C6 halogalkyl, C3 -C6 alkenyl, C3 -C6 haloalkenyl or C3 -C6 alkynyl, and the salts of these compounds with metals and nitrogen bases.
Patent BR-8806671-A (BR)
Inventor: ANTHONY THOMAS RICHARD
IPC: C23C16/02
Filed: 1988-12-16
Abstract: Boron is used as a diamond crystal nucleation and growth enhancer on a substrate in a CVD process of nucleating and growing diamond crystals on a substrate exposed to an activated hydrogen-hydrocarbon gas mixture.
Patent BR-8905808-A (BR)
Inventor: BLADE ROBERT JOHN
IPC: C07C327/44
Filed: 1989-11-16
Abstract: 1) The present Application discloses pesticidally active compounds of the formula (I):  Q Q<1> CR<2> = CR<3> CR<4> = CR<5>C (=X) NHR<1> or a salt thereof, wherein Q is an monocyclic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each optionally substituted, or Q is a dihalovinyl group or a group R<6>-C IDENTICAL C- where R<6> is C1-4 alkyl, tri C1-4 alkylsilyl, halogen or hydrogen; Q<1> is a 1,2-cyclopropyl ring optionally substituted by one or more groups selected from C1-3 alkyl, halo, C1-3 haloalkyl, alkynyl, or cyano; R<2>,R<3>, R<4> and R<5> are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C1-4 alkyl or C1-4 haloalkyl; X is oxygen or sulphur; and R<1> is selected from hydrogen and C1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifuoromethyl, trifluoromethylthio or C1-6 alkoxy, their preparation, pesticidal compositions containing them and their use against pests.
Patent BR-8906656-A (BR)
Inventor: SEIFERT GOTTFRIED
IPC: C07D239/60
Filed: 1989-12-21
Abstract: 4,6-Bis(difluoromethoxy)pyrimidines of formula I    <IMAGE>  (I) wherein R is C1-C4alkyl or unsubstituted or substituted phenyl or benzyl, are prepared by reacting a 4,6-dihydroxypyrimidine dialkali metal salt of formula II    <IMAGE> (II)  wherein R is as defined for formula I and Me is an alkali metal, with chlorodifluoromethane in a solvent selected from the group consisting of ketones and alkyl cyanides, in the presence of 0.05 to 1.1 mol of water per mol of dialkali metal salt of formula II.
Patent BR-9000509-A (BR)
Inventor: HAEBERLE RONALD MASON JR
IPC: C22C32/00
Filed: 1990-02-06
Abstract: A mechanically alloyed composition of matter or alloy containing 30-40% chromium, 5-25% cobalt, 0.5-10% iron, 0.2-0.6% aluminum, 0.3-1.2% titanium, up to 0.15% carbon, about 0.2-1% yttria, up to about 0.3% nitrogen, the % titanium being at least about 1.4 times the % nitrogen, minor amounts of optional elements, the balance being essentially nickel. The consolidated and hot worked alloy with coarse grains produced by heat treatment at about 1300 DEG C is useful in service requiring hot strength along with extraordinary resistance to oxidation, sulfidation and hot corrosive media. Specific utilization of the alloy of the invention is contemplated in handling molten glass and in utensils adapted to be used in contact with molten glass, e.g. spinners.
Patent BR-9102076-A (BR)
Inventor: CHRISTENSEN SCOTT C
IPC: G01N1/00
Filed: 1991-05-21
Abstract: A material analyzer includes a container (10); a radiation source (12) disposed within the container; a detector (14) disposed within the container for detecting radiation that is secondarily emitted by a material sample within an activation region (28) located between the radiation source and the detector when the material sample is bombarded by radiation from the radiation source and for producing signals in response to said secondarily emitted radiation; a computer (20) for processing the signals to determine the content of the material sample; and a carrousel (16) for transporting a material sample from outside the container to within the activation region. The carrousel is disposed about an axis of rotation located between the activation region and a receiving region (40) located outside the container, and has a pair of sample containment chambers (42, 44) that are alternately moved between the receiving region and the activation region when the carrousel is rotated about said axis. A radiation shield (18) within the container shields the the outside of the container from radiation derived in the activation region from the radiation source. Material samples are placed in buckets (49) for loading into the sample containment chambers. The bucket includes a perimetric side wall (52) having a predominant surface area that is contoured on opposite sides of the side wall to define exterior indentations (54) in the predominant surface area; and a handle (50), including a pair of tongs (56) shaped and disposed for insertion into the side wall indentations, and a telescopic handle (58, 59) joining the tongs. <IMAGE>
Patent BR-9105360-A (BR)
Inventor: MODRAK JAMES P
IPC: D04H1/46
Filed: 1991-12-12
Abstract: High loft durable nonwoven material comprising facing and base components and corresponding process for preparation by     (a) forming and compiling a facing component (1A); (b) lightly bonding the compiled facing webs, utilizing a low density bonding pattern (20A);   (c) laying a web (23A); and (d) bonding (20AB) said laid web to form a base component to said facing component, utilizing a substantially greater bonding density then employed for said facing component.   <IMAGE>
Patent BR-9206240-A (BR)
Inventor: FRIGO DOMENICO
IPC: G10K9/13
Filed: 1992-07-08
Abstract: PCT No. PCT/EP92/01538 Sec. 371 Date Mar. 11, 1994 Sec. 102(e) Date Mar. 11, 1994 PCT Filed Jul. 8, 1992 PCT Pub. No. WO93/01588 PCT Pub. Date Jan. 21, 1993.The horn includes a support casing (1 to 3) in which the peripheries of two facing diaphragms (10, 11) are restrained, a chamber (12) of variable volume being defined between the diaphragms (10, 11) and communicating with a sound-emission duct (50, 51, 70). Respective, opposed ferromagnetic armatures (17, 18) are connected to the diaphragms (10, 11). When a control solenoid (15) is excited by an intermittent current, it causes the armatures (17, 18) to move in opposition and the diaphragms (10, 11), to vibrate in counterphase.
Patent BR-9302681-A (BR)
Inventor: LEONI CARLO
IPC: A61H33/02
Filed: 1993-06-28
Abstract: An inner shell (20) is contained, and able to rotate, within an outer shell (10) fixed to a hole (9) in the tub (8); an inner duct (21) facing the tub is fixed to the shell (20), to which there is also joined a tubular element (40) communicating with a first chamber (27) which has its front mouth (41) positioned within the inner duct (21); a unidirectional valve means (44, 45, 46) is applied to the mouth (41) and arranged to close the passage through the mouth (41) when the pressure in the region to the front of the mouth (41) is greater than in the region to the rear; in the duct (21) there is a tubular valving member (50) having an axial cavity containing the front mouth (41) of the tubular element (40) and comprising an intermediate section (50a) which on making contact with the outer surface of the intermediate portion (43) of the tubular element (40) closes the communication between a second chamber (28) and the front mouth (22) of the inner duct (21); the valving member (50) is normally urged into its closure position by elastic means (51) and is able to undergo axial movement as a result of a difference in pressure between the region upstream and the region downstream of said intermediate section (50a). <IMAGE>
Patent BR-9403572-A (BR)
Inventor: HERTEL LARRY WAYNE
IPC: C07H/
Filed: 1994-09-15
Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful in the preparation of 2'-deoxynucleosides, and processes thereto.
Patent BR-9407622-A (BR)
Inventor: SNOWDEN GUY B
IPC: G06Q50/34
Filed: 1994-09-26
Abstract: A wagering system such as a lottery with a central computer communicating with agent terminals at which tickets are issued, for example in convenience stores and the like, has a player-operated win-checking system coupled to the communications network, preferably as a peripheral to the agent terminal but possibly as a separate network terminal. Player choices and game identifications are bar coded on the tickets. A player scans the ticket automatically to trigger comparison of the bar coded data with winning entry data kept in a past game memory, such that the system need not resort to stored data on individual wager transactions to check for wins. This reduces the burden on the agent and the network because most issued tickets need not be checked by attempting to validate them for a payout. A limited number of past games are stored, e.g., the most recent thirty Keno game cycles of a game run at five minute intervals. One or more of the win checking system, the agent terminal and the central computer can hold the past game memory. Winning choice data is downloaded after each game, or scanned player choices are uploaded, to effect the comparison. If a ticket is too old for the corresponding game data to remain in the past game memory, the player is directed to the agent, who can use the terminal to attempt to validate the old ticket as a winner.
Patent BR-9502938-A (BR)
Inventor: KLEMENT JOHANN
IPC: F24C15/34
Filed: 1995-06-27
Abstract: The thermal insulation is used for enclosing the sides of the oven space and provided by several relatively spaced foil layers, joined together at defined points to form a cellular structure, with a number of air-filled pockets. At least one of the foil layers is provided with an air-tight sealed edge on all sides, acting as a flexible fixing and/or coupling element. Pref. the layers are provided by A1 foils, each layer comprising at least three foils, two of which act as cover layers (a,d) on either side of at least one central spacer foil (b,c) with a meandering configuration. <IMAGE>
Patent BR-9506262-A (BR)
Inventor: GROENBERG VIDAR
IPC: D21C5/00
Filed: 1995-06-14
Abstract: The invention provides thermostable xylanases.
Patent BR-9603042-A (BR)
Inventor: MICHELOTTI ENRIQUE LUIS
IPC: A01N37/18
Filed: 1996-07-10
Abstract: A method for controlling phytopathogenic fungi comprises applying a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of manganese-zinc ethylenebis(dithiocarbamate), manganese ethylenebis(dithiocarbamate), zinc ammoniate ethylenebis(dithiocarbamate), zinc ethylenebis(dithiocarbamate), 2-cyano-N-((ethylamino)carbonyl)-2-(methoxhyimino)acetamide, and (E,Z) 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl)morpholine to plant seed, to plant foliage or to a plant growth medium and provides higher fungicidal activity than separate use of the same compounds.
Patent BR-9603714-A (BR)
Title: Processo de digitalização, reprodução e/ou modificação de um corpo tridimensional a partir do seu deslocamento rotativo sobre um dos eixos
Inventor: HARTKOPF HEINZ HUGO
IPC: G06T15/00
Filed: 1996-08-22
Abstract: Relatório Descritivo da Patente de Invenção <B>'PROCESSO DE DIGITALIZAçãO, REPRODUçãO E/OU MODIFICAçãO DE UM CORPO TRIDIMENSIONAL A PARTIR DO SEU DESLOCAMENTO ROTATIVO SOBRE UM DOS EIXOS'<D>. A presente invenção refere-se a um inovador processo para obter dados digitalizados que permitem a reprodução e/ou modificação de um corpo tridimensional qualquer de superfície irregular, através do deslocamento angular rotativo desse corpo segundo um dous eixos de um dispositivo. O processo emprega um dispositivo que permite girar o corpo (1) em ângulo de 360° (3) sobre o eixo Z (2). Um senssor (eletrónico ou laser) (4) se desloca sobre o eixo X (5) em ângulo reto (7) em relação ao  eixo Z (2). Ao tocar a superfície do corpo tridimensional (1), este sensor (4) mede, para cada deslocamento angular obtido pelo movimento giratório, a distância relativa desse ponto superficial do corpo em relação ao eixo Z (raio). O sistema registra cada um dos pontos superficiais do corpo (1),  que são definidos pela associação do deslocamento do sensor (4) sobre o eixo X (5) ao respectivo ângulo de deslocamento para cada posição sobre o eixo Z, ou seja, por um conjunto seq³encial de coordenadas polares. Tanto a graduação angular como o deslocamento (8) sobre o eixo Z (2) podem ser modificados. Coordenadas polares são geradas para uma determinada seção (10) do corpo tridimensional (1). A partir destes dados armazenados em  banco de dados (9) pode-se reproduzir este mesmo corpo (1). quando modificados, estes dados permitem produzir umnovo corpo. O novo procedimento é composto e três partes essenciais, que são:  1) digitalizar as dimensões de um corpo tridimensional existente (1);  2) armazenar estes dados binários em bancos de dados ou outros meios de armazenagem passíveis de modificação ou adequadação as novas necessidades; 3) criação de um novo corpo tridimensional irregular, onde cada seção pode ser composta por raios irregulares a partir de dados binários gerados com o uso de computadores; 4) produzir corpos tridimensionais a aprtir dos dados originais ou modificados.
Patent BR-9610551-A (BR)
Inventor: WEAVER LINDSAY A JR
IPC: H04B1/69
Filed: 1996-08-29
Abstract: A method and apparatus for time division duplex (TDD) repeating a spread spectrum signal, where spread spectrum signal is comprised of a series of code symbol modulated with a pseudonoise (PN) sequence. The TDD repeater receives intermittently the spread spectrum signal at a location remote from a source supplying the spread spectrum signal. The TDD repeater amplifies and delays the received spread spectrum signal by a predetermined amount. The TDD repeater transmits intermittently the delayed amplified received spread spectrum signal such that the TDD is not receiving the spread spectrum signal when it is transmitting the signal energy.
Patent BR-9709416-A (BR)
Inventor: BORKOW GADI
IPC: A61K31/34
Filed: 1997-05-23
Abstract: Method for preventing or inhibiting the transmission of HIV to susceptible uninfected cells by administering to the HIV, to cells infected with HIV, and/or to the uninfected cells, an effective amount of a compound of formula (I), wherein X is O or S, prior to the HIV or the cells infected with HIV, contacting the uninfected cells.
Patent BR-9714595-A (BR)
Title: Método e aparelho para transmitir informações em uma rede de comunicação
Inventor: BRUCKERT EUGENE J
IPC: H04W36/18
Filed: 1997-12-19
Abstract: <B> MéTODO E APARELHO PARA TRANSMITIR INFORMAçõES EM UMA REDE DE COMUNICAçãO<D> Em um sistema  de comunicação em que os limites de quadro para quadros distintos para usuários diferentes podem ser descentrados em relação um ao outro, a designação de uma unidade remota (125) para descentragem de quadro específica ocorre por um processador (321) que determina uma descentragem de quadro pertencente a um grupo que é o grupo menos congestionado de todos os possíveis grupos. Além disso, durante a transferência da unidade remota (125) de uma estação de base servidora (130) para uma estação de base vizinha, há uma tentativa de manter a unidade remota (125) dentro do mesmo grupo de chamada; contudo, se o mesmo grupo de chamada da estação de base vizinha estiver cheio, a unidade remota (125) será colocada em um segundo grupo de chamada que é um grupo de chamada anterior ao grupo de chamada atual.
Patent BR-9802186-A (BR)
Title: Processo para obtenção de produtos cerâmicos com esqueleto.
Inventor: PAIXAO VALADAR EZEQUIEL DA
IPC: B28B11/00
Filed: 1998-06-29
Abstract: <B>''PROCESSO PARA OBTENçãO DE PRODUTOS CERâMICOS COM ESQUELETO''<D> que consiste em produzir cerâmicos (figuras 1, 2, 3 e 4) utilizando terra, caulim e cimento. Este método dispensa o processo de queima destes produtos, que são moldados sob pressão em matrizes uniformes; o que acarreta um menor custo de fabricação e maior precisão em suas medidas. Com a implantação do esqueleto (I) o produto torna-se mais resistente ; sendo  possível ainda  colori-lo ou personalizá-lo.