baber/WOPTO huggingface dataset:
Patent IL-101235-A0 (IL)
Title: Pulmonary administration of granulocyte colony stimulating factor
IPC: A61K38/00
Filed: 1992-03-15
Abstract: Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and powder inhalers. Aerosol administration in accordance with this invention results in significant elevation of the neutrophil levels that compares favorably with delivery by subcutaneous injection. G-CSF can be administered in this manner to medically treat neutropenia, as well as to combat or prevent infections.
Patent IL-103019-A0 (IL)
Title: Dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/4418
Filed: 1992-09-02
Abstract: <CHEM>   <CHEM>       (i) -(CH2)m-CH=CH-Ph,   (ii) <CHEM>     (iii) <CHEM>     (iv) <CHEM>   Dihydropyridine derivatives of formula (I), wherein Het is  alpha or beta  ; A represents a direct linkage, -CH2-,-CH2-CH2-or, when Het is alpha  , A may also represent -CH=CH-; R is hydrogen or halogen; C1-C3 alkyl or C1-C3 alkoxy; one of R3 and R4 is C1-C3 alkyl optionally omega substituted by C1-C3 alkoxy and the other is independently C1-C3 alkyl optionally substituted by C1-C3 alkoxy or ( gamma ); R5 is hydrogen or C1-C6 alkyl optionally substituted by -N(RcRd); one of R1 and R2 is a group -OR min  wherein R min  is C1-C6 alkyl optionally substituted by C1-C3 alkoxy or cyano, and the other is independently a) C1-C3 alkyl, b) a group -OR min , c) a group ( psi ) or d) a group -OR<IV> wherein R<IV> is hydrogen or a substituent selected from (i), (ii), (iii) and (iv), are useful antitumor activity promoting agents.
Patent IL-104353-A0 (IL)
Title: Amine-oxides
IPC: G01N21/71
Filed: 1993-01-08
Abstract: Amine oxides of the general formula <IMAGE> in which R1 and R2 represent alkyl groups having 1-4 C atoms, R3 represents hydrogen, hydroxyl or an alkoxy group having 1-4 C atoms and m and n denote integers which fulfil the conditions 1 </= m </= 8 or 0 </= n </= 4, with the proviso that n does not represent 0 if R3 is a hydroxyl or alkoxy group, can be used advantageously for the production of mouldable or spinnable cellulose solutions having a slight tendency to crystallise.
Patent IL-106219-A0 (IL)
Title: Assay system for degenerative muscle disease
IPC: G01N33/561
Filed: 1993-07-02
Abstract: An assay system useful for detecting denervated or degenerating muscle by measuring the amount of soluble ciliary neurotrophic factor receptor in body fluids is described.
Patent IL-111207-A0 (IL)
Title: Photovoltaic cell system and an optical structure therefor
IPC: F24S23/00
Filed: 1994-10-09
Abstract: A high radiation concentration, photovoltaic cell system, including at least one optical structure in the form of a three-dimensional body (2) having a first surface (6) and a second surface (8), the body is made of a material at least partly transparent to light and having formed between the surfaces an array of contiguous light radiation concentrators. The concentrators define on the first surface photovoltaic cell-attaching areas while the second surface is, at least indirectly, exposed to light radiation. There is also provided at least one solar radiation collecting and/or reflecting device (16) arranged to direct solar radiation to be impinged on the second surface of the optical structure.
Patent IL-111359-A0 (IL)
Title: Pyrotechnic smoke composition
IPC: C06D3/00
Filed: 1994-10-21
Abstract: PCT No. PCT/DE94/01237 Sec. 371 Date Dec. 18, 1995 Sec. 102(e) Date Dec. 18, 1995 PCT Filed Oct. 19, 1994 PCT Pub. No. WO95/11871 PCT Pub. Date May 4, 1995In a continuously burning pyrotechnic composition, compounds of graphite serve as additional components that are capable of thermal expansion in the C-axis perpendicular to the lattice plane and expand in the reaction zone of the pyrotechnic composition, being released with the reaction products of the burning pyrotechnic composition. This permits production of camouflage smokes that are effective in the optically visible range, the IR range and the MMW-RADAR range of electromagnetic radiation.
Patent IL-131746-A0 (IL)
Title: Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
Inventor: CORPORATION IDEC PHARMACEUTICA
IPC: C12N15/85
Filed: 1998-03-09
Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
Patent IL-132611-A0 (IL)
Title: Synthetic genes and polypeptides and pharmaceutical compositions comprising them
IPC: C07K14/47
Filed: 1999-10-27
Abstract: Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clusters (hereinafter IEC) of autoantigen(s) related to a specific autoimmune disease, wherein said at least two IECs may be derived from a sole autoantigen or from at least two different autoantigens related to said autoimmune disease, and polypeptides encoded thereby, can be used for the treatment and the diagnosis of autoimmune diseases such as multiple sclerosis (MS), insulin-dependent diabetes mellitus (IDDM), rheumatoid arthritis (RA), myasthenia gravis (MG) and uveitis.
Patent IL-137257-A0 (IL)
Title: Pig pheromones to decrease stress, anxiety and aggressiveness
IPC: A61K47/12
Filed: 1999-01-21
Abstract: A composition comprising a mixture of fatty acids such as linoleic, oleic and palmitic acids or derivatives thereof derived from secretions of mammalian mammary glands. This composition can be utilized to decrease stress, anxiety and aggressiveness in mammals.
Patent IL-143840-A0 (IL)
Title: Cutting insert with universal identification
IPC: B23B27/16
Filed: 1999-12-09
Abstract: A cutting insert is disclosed with triangular shapes imprinted on the top surface of the insert whereby the number of triangular shapes is representative of the cutting range for which the insert will function best. A method for imparting such shapes to the cutting insert is also disclosed.
Patent IL-147728-A0 (IL)
Title: Method for making debromohymenialdisine and analogs thereof
IPC: A61K31/55
Filed: 2000-07-19
Abstract: A method for making debromohymenialdisine (DBH) 2 and analogs thereof is described. One embodiment of the present method first comprises forming hymenin 4, and then converting hymenin into DBH 2 as described herein. One such embodiment first comprises providing a compound having Formula 3where R is independently selected from the group consisting of hydrogen and lower aliphatic, and X is independently selected from the group consisting of hydrogen and halogen. A compound having Formula 3, such as Compound 10 with R and X as hydrogen, is then converted to DBH 2 or an analog thereof. An alternative embodiment of the method comprises forming Compound 30 or Compound 32, which are then directly converted to DBH 2. Alternatively, Compound 30 can be converted to Compound 10, which is then subsequently converted to DBH 2 by reaction with a halogen in the presence of an acid. The method of the present invention can be used to make analogs of DBH 2, including alkoxy derivatives, such as Compound 12, and conjugated diene derivatives, such as Compound 14.
Patent IL-151149-A0 (IL)
Title: Zinc finger domains and methods of identifying same
IPC: C07K14/47
Filed: 2001-02-17
Abstract: Disclosed is an in vivo selection method for identifying zinc finger domains that recognize any given target site. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites.
Patent IL-161586-A0 (IL)
Title: Non-explosive energetic material and a reactive armor element using same
IPC: C06B23/00
Filed: 2004-04-22
Abstract: The present invention provides elements for making a protective reactive armor to be fitted on the outside of an enclosure liable to be exposed to attack by shaped-charge warheads and other threats, such as kinetic energy projectiles and fragments, to thereby enhance survivability of the enclosure and its contents. The invention further provides a non-explosive energetic material useful for such reactive armor elements.
Patent IL-194629-A0 (IL)
Title: Purification processes for isolating purified vesicular stomatitis virus from cell culture
Filed: 2008-10-07
Abstract: A process is described for purifying vesicular stomatitis virus (VSV) from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture fluid by low-speed centrifugation and recovering the VSV in the supernatant; filtering the supernatant through a 0.2 to 0.45 μm filter and recovering the VSV in the filtered solution; loading the VSV filtered solution onto a anion exchange membrane adsorber equilibrated with a first pH buffered salt solution, eluting the VSV from the anion exchange membrane adsorber with a second pH buffered salt solution and recovering the eluted VSV fractions; purifying the recovered VSV by tangential flow filtration (TFF) using a TFF membrane having a molecular weight cutoff between 300 kDa and 1,000 kDa and recovering the VSV in the retentate, and filtering the VSV retentate through a 0.2 to 0.22 μm filter and recovering the VSV in the filtered solution.
Patent IL-208870-A0 (IL)
Title: Method for manufacturing three-dimensional objects and machine employing said method
Filed: 2010-10-21
Abstract: Method for manufacturing three-dimensional objects (W) consisting of superimposed layers (L) of a base material (M), liquid at ambient temperature and capable of solidifying permanently following a stimulating action, comprising the following operations: spreading a layer (L1) of the liquid base material (M) on the preceding layer (L), selectively exposing the layer (L1) to stimulation in one or more predefined areas (K), repeating the spreading operation and the exposure for each successive layer of the three-dimensional object (W), cooling the layers (L) to a predefined operating temperature below ambient temperature before the stimulation, in order to make the base material (M) solidify.
Patent RO-125416-A0 (RO)
Title: Device to be attached to bottles for self-watering plants in pots or boxes
Inventor: BIRSAN CLAUDIU ALEXANDRU
IPC: A01G27/02
Filed: 2010-01-06
Abstract: The invention relates to a device for watering plants in a pot or a box. According to the invention, the device comprises two cavities (B and C) having the role of supporting an upside down bottle and the role of supporting said device on the ground near a pot, respectively, connected to each other by means of a threaded cylinder (A) wherein there is screwed the bottle head provided with two union bodies (a) having two small flexible pipes (D) descending through a slit from a second cavity (C) into a tray or plate of the pot through which the water drains from the bottle.
Patent RO-126909-A0 (RO)
Title: Intensive foot cream composition
Inventor: STAN VIOREL ADRIAN
IPC: A61K35/08
Filed: 2011-07-11
Abstract: The invention relates to an intensive foot cream composition with Techirghiol water and mud. The claimed cream comprises 3% thermal water, 2% sesame oil, 0.5% bee wax, 6% aluminium starch octenyl succinate, 0.5 % shea butter, 3% triethyl citrate, 0.5 % natural menthol and 0.5 % natural camphor together with usual ingredients and excipients for the remainder to 100%.
Patent RO-131026-A0 (RO)
Title: Process and compositions for preparing complex plant extracts with effects in immune system stimulation and control
Inventor: NICOLESCU CRISTINA ELENA
IPC: A61K36/48
Filed: 2015-04-07
Abstract: The invention relates to a process for preparing complex plant extracts with effects in immune system stimulation and control. According to the invention, the process consists in associating a mixture of three extracts resulting from the plant Mimosa pudica linn with powder from the plant Mondia whitei, in a ratio of 5:3, the final blend being purified by osmosis for 24 h, at a temperature of 32°C, with an extractive solution, in a total powder : extractive solution ratio of 1...6:1 (total powder mass) : (extractive solution volume).
Patent RO-131145-A0 (RO)
Title: Compressed-air cooling installation and device
Inventor: TEIŞANU FLORIN
IPC: F25B9/04
Filed: 2015-12-17
Abstract: The invention relates to a compressed-air cooling installation and device, meant for air-conditioning, by cooling, the interior of a room or enclosure, such as a dwelling space, a working space or a technological space, or a motor vehicle cabin. According to the invention, the installation operation is based on the thermo-dynamic effect of expansion of compressed air in centrifugal field and the integral transformation thereof into cold air harmless to humans and environment, the installation consisting of a filter (1) for purifying the air sucked from the atmosphere, a filter (2) for purifying the air sucked from inside the room, a distributor (3) with two ways and two positions, a compressed-air source (4), an air-air-type heat exchanger (5), a micro-filter (6) for purifying the vitiated air during the compression process, a manometer (7), a pressure valve (8) which opens when the pressure in the circuit reaches a preset value within the range 2.5...4 bar, a pneumatic cooling device (9) which by expansion in centrifugal field produces air having the temperature below the environment temperature, an acoustic damper (10), an air spreader (11) for spreading the cold air into the room, a pneumatic valve (12) for depressurizing the room and a control module (13) with microprocessor
Patent AP-2001002187-A0 (AP)
Title: Piperidines as CCR5 modulators.
Inventor: ARMOUR DUNCAN ROBERT
IPC: C07D/
Filed: 1999-12-01
Abstract: Compounds of formula 1: [Regiona]- [regionß]- [region?]- [regiond]which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds
Patent AP-2001002199-A0 (AP)
Title: Novel streptococcus antigens
Inventor: HAMEL JOSEE
IPC: A61P25/00
Filed: 1999-12-20
Abstract: Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as dignostic assays for detecting streptococcus bacterial infection.
Patent AP-2002002645-A0 (AP)
Title: Production of improved cereal grain or cereal flour
Inventor: BANERJEE RINKA
IPC: A23L7/10
Filed: 2001-01-19
Abstract: Cereal flours, in particular wheat flour and maize flour with good properties for application in chapati, respectively in ugali can be made by a heat treatment at 100 to 350oc for 10-120 sec, while agitating it slightly. The grains so obtained can be milled and the flour resulting from the milling can be blended with conventional flours. Applying the process to maize grains results in novel products.
Patent AP-2004003168-A0 (AP)
Title: Phosphonates and derivatives thereof as enhancers of the activity of insecticides
Inventor: STOCK DAVID
IPC: A01N51/00
Filed: 2003-05-22
Abstract: An insecticidal composition having as an adjuvant a phosphonate or an alkoxylated derivative or dimer thereof. Preferred phosphonates are bis-(2-ethylhexyl)-2ethylhexylphosphonate, bis-(2-ethylhexyl)-octylphosphonate and bis-(butyl)butylphosphonate.
Patent MA-27547-A1 (MA)
Title: NOUVEAUX DERIVES DE 4-OXO-4,6,7,8-TETRAHYDRO-PYRROLO[1,2-a]PYRAZINE-6-CARBOXAMIDES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Inventor: DE NANTEUIL GUILLAUME
IPC: A61P7/02
Filed: 2005-03-18
Abstract: NOUVEAUX DERIVES DE 4-OXO-4,6,7,8-TETRAHYDRO-PYRROLO[1,2-a]PYRAZINE-6-CARBOXAMIDES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composé de formule (I) : dans laquelle : représente un groupement 1-oxydo-pyridinyle substitué par le reste de la molécule en l'une quelconque des positions 2, 3 ou 4, * m et n, identiques ou différents, représentent chacun un entier compris entre 1 et 3, * R1 représente un atome d'hydrogène ou un groupement alkyle, * R2 et R3, identiques ou différents, représentent chacun un atome ou groupement choisi parmi les atomes d'hydrogène et d'halogène et les groupements alkyle, hydroxy, acyloxy et alkoxy, ou forment ensemble, avec l'atome de carbone qui les porte, un cycloalcane ayant de 3 à 6 atomes de carbone, * R4 et R5 représentent chacun un atome d'hydrogène, ou sont adjacents et forment ensemble, avec les atomes de carbone qui les portent, un cycle benzo, * Ar représente un groupement aryle ou hétéroaryle. Médicaments.
Patent MA-39282-A1 (MA)
Title: Composés n-hétéroaryle substitués par un n-azaspirocycloalcane et compositions pour inhiber l'activité de shp2
Inventor: CHEN ZHUOLIANG
IPC: C07D241/20
Filed: 2015-01-16
Abstract: La présente invention concerne des composés de formule (i) : dans laquelle p, q, y1, y2, r1, r2a, r2b, r3a, r3b, r4a, r4b, r5a, r5b, r7 et r8 sont définis dans le résumé de l'invention ; aptes à inhiber l'activité de shp2. L'invention concerne en outre un procédé pour la préparation de composés selon l'invention, des préparations pharmaceutiques comprenant de tels composés et des méthodes d'utilisation de tels composés et compositions dans la prise en charge des maladies ou des troubles associés à l’activité aberrante de shp2.
Patent MA-43608-A1 (MA)
Title: Procédé de détection préventive de l'hypoglycémie en temps réel
Inventor: Bakhouya Mohamed
IPC: A61B5/02
Filed: 2018-11-05
Abstract: L’invention concerne un procédé de détection préventive de l’hypoglycémie en temps réel caractérisé par : - un dispositif portable incorporant des capteurs pour la mesure des signes vitaux d’un utilisateur. - un serveur intermédiaire destiné à recevoir et traiter les données issues du dispositif portable. - une plateforme internet des objets et big data pour l’acquisition, traitement, visualisation et stockage des données issues du serveur intermédiaire. - un module de notification lié à la plateforme internet des objets et big data pour la génération des alertes déterminées suite aux signes vitaux issues du diapositif portable. - une plateforme de notification du voisinage de l’utilisateur au cas d’une état d’hypoglycémie sévère.
Patent MA-61230-A1 (MA)
Title: Composition contenant une substance osmotique et utilisation de la composition
Inventor: SCHMIDTS THOMAS
IPC: A61K47/02
Filed: 2021-12-16
Abstract: L'invention concerne une composition destinée à être utilisée dans le traitement d'irritations cutanées, dues à des interactions avec des plantes ou des animaux, sur ou dans la peau, la composition contenant au moins une substance osmotique et/ou hygroscopique.
Patent UY-23971-A1 (UY)
Title: Pelicula refinada por estiramiento y laminado tramado al azar y su proceso de formacion
Inventor: ANN LOUISE MCCORMACK
IPC: A01N25/00
Filed: 1995-06-02
Abstract: Se revela en la presente una película afinada por estiramiento y laminado tramado al azar así como un proceso para hacer dicho laminado ya sea en una configuración de dos o tres capas. La película tiene un calibre efectivo de 0,55 mils (0,00055 pulgadas) o menos y una relación resistencia de rasgadura. Elmendorf dirección de máquina a dirección transversal de 3,5 o mayor. El laminado resultante tiene una amplia variedad de usos que incluyen componentes de elementos relacionados con el cuidado de la salud como ser paños estériles, cortinas, batas quirúrgicas y revestimientos contacto-cuerpo y cubiertas externas para productos absorbentes de higiene personal. Con respecto a la figura 1 se muestra una película afinada por estiramiento y laminado tramado al azar (10) incluyendo una primera capa (12) y una primera capa de soporte de tejido tramado al azar fibroso (14).
Patent UY-24985-A1 (UY)
Title: Formas cristalinas hidratadas de atorvastatina forma i
Inventor: SHINSUKE NAKAGAWA
IPC: C07D/
Filed: 1998-04-30
Abstract: La presente invención se refiere a nuevas formas cristalinas de atorvastatina que se conoce con el nombre químico de ácido [R-(R*,R*)]-2-(4-fluorofenil)-beta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino) carbonil]-1h-pirrol-1-heptanoico sal de hemi calcio que sirve como agente farmacéutico, a métodos para su producción y aislamiento, a composiciones farmacéuticas que incluyen estos componentes y un portador farmaceuticamente aceptable, y a métodos de tratamiento. Los nuevos componentes cristalinos de la presente invención son útiles como inhibidores de la enzima 3-hidroxi-3-metilglutaril-coenzima A reductasa (HMG-Coa reductasa) y, por lo tanto, son agentes hipolipidémicos e hipocolesterolémicos útiles.
Patent UY-26729-A1 (UY)
Title: Alquilaminas heterocíclicas como antagonistas de los receptores muscarínicos
Inventor: MAAG HANS
IPC: C07D279/06
Filed: 2001-05-24
Abstract: Esta invención se refiere a compuestos que son generalmente antagonistas de los receptores muscarínicos M2/M3 y que están representados por la fórmula I en donde X, Y y Z son -O-, -S- o >N-R5, y los otros sustituyentes son tal como se definen en la especificación; o profármacos, isómeros individuales, mezclas racémicas o no-racémicas de isómeros, y sales o solvatos farmacéuticamente aceptables de los mismos. La invención además se refiere a las composiciones farmacéuticas que contienen dichos compuestos. Los procesos para su preparación y su utilidad para el tratamiento de enfermedades asociadas con anomalías en el músculo liso.
Patent UY-28164-A1 (UY)
Title: Cuadros en metal sin respaldo con proyección en dimenciones diferentes
Inventor: GONZALEZ RICARDO
Filed: 2004-01-09
Abstract: Solamente para resumir separamos el título en dos partes. NS1 Cuadros de metal sin respaldo NS2- Con proyección en dimensiones diferentes. NS1 - Las pinturas o cuadros han tenido respaldos diversos, piedra, lienzo, madera, mural etc. Todos, usando pinturas sobre el respaldo correspondiente. Estos cuadros en metal no están construidos sobre ningún respaldo, la imagen y la pintura conformas el cuadro. NS 2 - La proyección es parte integrante del cuadro. Las dimensiones de la figura proyectada varia de acuerdo al enfoque de la luz. El tamano de la proyección varia de acuerdo a la distancia del cuadro y el lugar en que va a ser proyectado.
Patent UY-29031-A1 (UY)
Title: 2-(piridin-2-il)-pirimidinas y su uso para combatir hongos daninos
Inventor: GROTE DR THOMAS
IPC: A01N43/54
Filed: 2005-07-22
Abstract: La presente invención se refiere a compuestos de 2-(piridin-2-il)-pirimidinas de la fórmula general (I), donde los sustituyentes son tales como se especifican en la Memoria Descriptiva; y a su uso para combatir hongos daninos, así como a los agentes fitosanitarios que contienen estos compuestos como componente activo.
Patent UY-30263-A1 (UY)
Title: Utilizacion de un compuesto anti-aterotrombotico para la obtencion de medicamentos destinados al tratamiento de los trastornos vasculares
Inventor: LAVIELLE GILBERT
IPC: A61K31/18
Filed: 2007-04-09
Abstract: La presente invención se refiere a la utilización de un antagonista específico de los receptores TP para la obtención de medicamentos destinados al tratamiento de los trastornos vasculares en el paciente que presenta un antecedente de accidente vascular cerebral, especialmente para la reducción de los sucesos cerebro-vasculares y cardiovasculares en los pacientes que presentan un antecedente de accidente isquémico cerebral (AIC) o de ataque isquémico transitorio (AIT).