baber/WOPTO huggingface dataset:
Patent CR-20200539-A (CR)
Title: Chimeric receptors to dll3 and methods of use thereof
Inventor: THOMAS MELISSA
Filed: 2019-04-10
Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells to DLL3 are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the DLL3 antigen binding molecules and engineered immune cells.
Patent CR-20210290-A (CR)
Title: Processes of making and crystalline forms of a mdm2 inhibitor
Inventor: COCHRAN BRIAN
Filed: 2014-06-09
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3- chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3- methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Patent EC-SP077997-A (EC)
Title: Moduladores de alquilquinolina y alquilquinazolina cinasa
Inventor: GAUL MICHAEL DAVID
IPC: C07D401/04
Filed: 2007-12-10
Abstract: La invención se refiere a compuestos alquinolina y alquinazolina de fórmula I:en donde R1, R2, R3, B, Z, G, Q y X son como se define en la presente, el uso de dichos compuestos como moduladores de proteína tirosina cinasa, particularmente inhibidores de FLT3 y/o c?kit y/o TrkB, el uso de dichos compuestos para reducir o inhibir la actividad cinasa de FLT3 y/o c kit y/o TrkB en una célula o un sujeto, y el uso de dichos compuestos para la prevención o tratamiento en un sujeto de un trastorno proliferante celular y/o trastornos relacionados a FLT3 y/o c kit y/o TrkB; la presente invención se refiere además a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a métodos para el tratamiento de condiciones tales como cánceres y otros trastornos proliferantes celulares.
Patent EC-SP941111-A (EC)
Inventor: NEIDHART WERNER
IPC: C07D239/69
Filed: 1994-06-27
Abstract: Compounds of the formula <IMAGE> in which R<1> to R<9>, R<a>, R<b>, X, Y, Z, m and n have the meaning given in the description, can be used as medicines, in particular for the treatment and prophylaxis of conditions associated with endothelin activities.
Patent FI-20010194-A (FI)
Inventor: NUORTILA OLLI SAKARI
IPC: H04L29/12
Filed: 2001-02-01
Abstract: The method makes possible to keep particular e-mails separate from other e-mails and is based upon an interaction between a plug-in program in the user's e-mail client program and a separate mediating server. User's private address and e-mail service address are saved in the mediating server. E-mail client program is programmed to send all private messages to the mediating server. When a message is sent the plug-in program removes the original user given recipient address on the recipient field temporarily to another field, and replaces it with the address of the mediating server. To the user the message appears to have been sent to the original recipient. The mediating server receives the messages, replaces the sender's address with the sender's private address in the mediating server, restores the original recipient address(es), from the other field of the message, to the recipient field(s) and sends the message to the original recipient(s).
Patent FI-20021629-A (FI)
Inventor: KIVINEN TIMO
IPC: H04W4/02
Filed: 2002-09-11
Abstract: A method for determining cell-specific location information, wherein the cell-specific location information to be used in a mobile communication network is encrypted using a predetermined encryption algorithm. The geographical coverage area corresponding with a particular cell is determined and the cell-specific location information and the geographical coverage area information are stored in a database and interlinked. A cell positioning service request is transmitted from a mobile station to a service provider, the cell positioning service request including the encrypted, cell-specific location information on the mobile station and, in response to the request, the service provider retrieves from the database the geographical coverage area information corresponding with the encrypted, cell-specific location information on the mobile station in the request, and transmits a cell positioning service message to the mobile station, the cell positioning service message including at least the geographical coverage area information.
Patent GB-1033140-A (GB)
Abstract: 1,033,140. Gas turbine ducted fan engines. MESSERSCHMITT A.G. Sept. 30, 1964 [Oct. 2, 1963], No. 39712/64. Heading F1J. The invention relates to a gas turbine ducted fan type jet propulsion engine, the fan duct being disposed around the turbine duct, the turbine driving the fan through epicyclic speed reduction gearing comprising a sun gear carried on the shaft of the turbine rotor and which engages with planet gears mounted on shafts carried by the fan and which engage also with a rotationary ring gear. The engine shown comprises an inner annular duct 23 through which gas flows to act on the turbine blades 1, and an outer annular duct 25 through which air flows to be acted on by the fan blades 2. The turbine rotor 31 is secured on a shaft 5 which has a sun gear 6 secured thereon, the sun gear engaging with planet gears 7 which also engage the fixed internal ring gear 8. The planet pinions are mounted on shafts 10 which are secured to the fan rotor 11 which constitutes a planet carrier. The fan blades 2 are secured to the fan rotor 11 by means of spokes 8 which extend across the annular duct 23 downstream of the turbine rotor blades 1. Fixed guide vanes 27 and 30 are disposed upstream and downstream of the turbine blades 1 and similarly fixed guide vanes 26 are disposed upstream and downstream of the fan blades 2.
Patent GB-1046087-A (GB)
Abstract: 1,046,087. Drying webs. HUPP CORPORATION. Feb. 17, 1964 [Feb. 15, 1963; April 9, 1963], No. 6465/64. Heading F4G. In apparatus for drying a continuously moving web of material, a stream of air heated in excess of 500‹ F. and without combustion products is directed at high velocity against the web surface, viz. at not less than 6000 feet per minute, and recirculating and reheating the air impinged on the web to increase its moisture content viz. to not less than 0À4 lb. of water per lb. of dry air and thereby to increase the drying ability of the air. In a web drying apparatus 10, Fig. 1, the web 26 passes about a heated cylinder 28 and has jets of heated air from nozzles 84 in a hood 24 directed at high velocity thereagainst, the air being fed by a blower 20 through an air heating unit 16 and supply duct 22 to the hood and exhausted therefrom through a return duct 32 for recirculation to the unit 16. The air heating unit 16 comprises a chamber 52 housing finned heating tubes 50 over which the air passes, the tubes being supplied with a liquid e.g. chlorinated biphenyl having a boiling point of not less than 500‹ F. and low decomposition rate, which is heated in tubes 34 by burners 36 in a unit 14. The hood 24 comprises a plenum chamber 82, Fig. 2, supplying air to the nozzles 84, each of which is formed from two sheet metal members 88 having converging nozzle portions 92 to form an outlet slot 94 for the air which is exhausted by passage between adjacent nozzles and through slots 116 in ribs 98 welded to adjacent nozzles to a transition section 118 of the hood 24 into the return duct 24. To control the moisture content of the air delivered to the hood 24, a make-up air duct 120 and a vent air duct 122 are provided, having valves 126, 128, respectively, which may be automatically controlled in accordance with a sensing unit in the return duct 32. Constant flow of liquid in the system of ducts 48, 54 between the units 14, 16 is achieved by the use of a by-pass conduit 64 having a valve 66 regulated by a differential pressure controller 68 actuated by sensing elements on the inlet and discharge sides of the circulating pump. Uniform temperature of the heated air passing from the unit 16 into the supply duct 22 by a by-pass conduit 56 between the ducts 48, 54 having a three-way valve 58 regulated by a controller 60 responsive to the temperature of the air in the duct 22 to proportion the flow of heated circulating liquid between the tubes 50 in the unit 16 and by-pass conduit 56.
Patent GB-1052762-A (GB)
IPC: B41F3/46
Abstract: 1,052,762. Printing apparatus. ADAMOVSKE STROJIRNY, NARODNI PODNIK. June 22, 1964 [June 22, 1963], No. 25656/64. Heading B6C. Apparatus for stopping the impression cylinder 1 of a stop cylinder printing press comprises a disc 2 secured to the shaft of the cylinder 1 and provided with an interior cam path 11, a pin 15 supported in a hub 17 and adapted on rotation of the cylinder to engage said path under the control of a cam 13, the operative surface of which is the same shape as said path, a lever 3 supporting said pin and provided with a fixed pivot 4, and an arm 6 and a pull rod 5 carrying a roller 9 and arranged to move said lever and said pin under the control of a drive cam 10. When the pin leaves the path 11 it is moved axially into its original position by a fixed member 16.
Patent GB-1054327-A (GB)
Abstract: 1,054,327. Cyclic C 12 -α-aminocarboxylic acids. CHEMISCHE WERKE HœLS A.G. Get. 25, 1963 [Oct. 27, 1962], No. 42143/63. Heading C2C. The invention comprises α-aminocarboxylic acids or their salts of the general formula in which n is 18, 20 or 22 and the C 12  ring contains 0 to 2 double bonds, and Me denotes hydrogen or a monovalent metal. The compounds may be prepared by reacting spirohydantoins of the general formula with an alkaline agent while heating, for example, in the range of 160‹ to 240‹ C. The hydantoins are described in Specification 1,045,888. Oxides, hydroxides and/or alkaline reacting salts of alkali metals and/or alkaline earth metals, for example tetra-alkali pyrophosphates, sodium carbonate, potassium carbonate, sodium hydroxide or potassium hydroxide may be used as alkaline agents. Sulphuric, hydrochloric, or p-toluenesulphonic acids may be used as acid agents. The alkaline or acid agents are used in at least stoichiometric amounts with respect to the hydantoins. The hydrolysis may take place in solution in alcohols or glycols or in aqueous suspension. In examples, cyclododecanone-p.nitrophenyl hydrazone is made from cyclododecanone and p-nitrophenyl hydrazine and converted to 1,3- diaza - spiro - [4,11] - hexadecane - dione - (2,4); the same product is made from cyclododecanone; the spiro hydantoin is converted to 1- amino cyclododecane carboxylic acid; cyclododecadiene-(1,5) one is converted to isomeric 1.3 - diazo - spiro - [4,11] - hexadecadienediones-(2,4).
Patent GB-1071592-A (GB)
Abstract: 1,071,592. Selective printing. LICENTIA PATENT - VERWALTUNGS - G.m.b.H. Aug. 4, 1964 [July 29, 1963], No. 31195/64. Heading B6F. [Also in Division G4] In a ticket printer of the selectable printing plate type, perforated plates attached to the stored printing plates traverse light beams to give pulses to actuate a common printing device for a record tape. The printing plates are stored in parallel compartments which are traversed by the ticket printing carriage to select any printing plate according to a reference scale. The printing plate 36 lifted from the store for printing causes the attached perforated plate 37 to modulate the digital light beams to give dark working pulses to the stepping mechanism 31 of the type wheels 30. The light beams are focused by lenses 16 and received through diaphragms 32 by photodiodes 15 connected to transistor amplifiers 19 and electromagnetic stepping mechanisms 31.
Patent GB-1083751-A (GB)
Abstract: 1,083,751. Electric meters. SOCIETE FRANCAISE D'ETUDES ET DE CONSTRUCTIONS ELECTRONIQUES 'COTELEC'. April 2, 1965 [April 3, 1964], No. 14161/65. Heading G1Q. An oscillograph consists of two galvanometer movements acting in mutually perpendicular directions on a single mirror, the mirror being carried by the moving element of the first galvanometer and the support with respect to which this first moving element moves itself being carried by the moving element of the second galvanometer. Each of the galvanometer movements takes the form of a Kelvin moving magnet galvanometer, i. e, a pair of astatically mounted magnets. Fig. 1 shows the principle of the instrument. The first galvanometer movement has two magnets 6a, 6b controlled by two (only one shown) fixed electromagnets 8 and carries the mirror 1, which is mounted for rotation about the common axis of the half shafts 4a, 4b. These are journalled in the ring 2 which is secured to the magnets 7a, 7b and half shafts 5a, 5b of the second galvanometer movement, this being controlled by two (only one shown) fixed electromagnets 9. The mirror thus moves about two mutually perpendicular axes in response to two respective control signals applied by way of the energizing coils 9, 10 of the two electromagnet pairs. In the preferred constructional form Figs. 2 and 3 (not shown) the half shafts take the form of torsion strips, the control electromagnets are each in two relatively adjustable portions to allow for adjustment of the flux gap in which the moving magnets move, the movement is immersed in liquid, and the whole instrument is housed in a sealed casing one face of which incorporates a lens of the optical system for detecting the mirror displacement. Although the coils of each pair of controlling electromagnets are normally connected in series or parallel, to allow for balanced operation by a single input, it is possible to provide for additional coils and so meter multiple inputs. Such additional coils must be provided in balanced pairs on the two electromagnets of the same galvanometer.
Patent GB-1095373-A (GB)
IPC: F16H47/06
Abstract: 1,095,373. Change-Speed control. TWIN DISC CLUTCH CO. April 15, 1966 [May 4 1965], No. 16712/66. Heading F2D. A load raising and lowering power transmission comprises a power source in series with a controllable-slip hydraulic disc clutch 12 and torque converter 26, the latter of which may be coupled to an output shaft 34 carrying a controllable-slip hydraulic disc brake 43, either directly or indirectly through a reverse gear 37, by a selector dog clutch 32, the clutches and brake being under the conjoint control of a single manual selector lever 106. The latter is mounted for universal movement to control the valves 78, 79 operating power clutch 12, and a brake release valve 85. With selector clutch 32 in the neutral position shown, valves 78, 79 cut off the pressure supply to clutch 12 and the supply to brake valve 85 is by-passed by a position valve 92, brake 43 being held engaged by loading springs 48, so avoiding free fall of the load in the event of power supply failure. Lateral movement of hand lever 106, effected by rotation of a hollow shaft 101 in a fixed sleeve 100, rotates an arm 110 to operate the shift yoke 112 of selector clutch 32 for raising or lowering of the load, and at the same time operates a push rod 116 to position valve 92 for blocking the by-pass 86 from brake valve 85. The arm 110 disengages from shift yoke 112 when clutch 32 is fully engaged to allow lever 106 to rotate a second arm 109 controlling the loading springs 80, 81 of the power clutch valves 78, 79, the loading spring 90 of the brake release valve 85 being operable simultaneously by a push rod 91 reciprocating within shaft 101 in response to longitudinal movement of lever 106. The hydraulic control circuit, Fig. 2 (not shown), includes connections to passages 23, 56 supplying cooling oil to the power clutch and brake, and also to passages 22, 55 communicating with centrifugal pressure balancing chambers 18, 48. In an alternative arrangement, Figs. 5- 7 (not shown), the selector dog clutch 32 is replaced by two hydraulic disc clutches, and the torque converter provides hydraulic braking during lowering of the load.
Patent GB-1227553-A (GB)
IPC: B23Q15/00
Filed: 1968-06-13
Abstract: 1,227,553. Cutting-out presses. BRITISH UNITED SHOE MACHINERY CO. Ltd. 13 June, 1968 [13 June, 1967], No. 28117/68. Heading B4B. [Also in Division H3]  In a cutting press of the swing beam type comprising a movable upper platen 12 in the form of a presser member and a fixed lower platen on which is mounted a conductive cutting pad 16 for supporting material to be cut and a superposed cutting knife and an hydraulic motor 14 for effecting relative movement of approach and separation of the platen 12 relative to the lower platen, means are provided for preventing false actuation, or undesired re-actuation, of the motor 14 because of operator or component failure after termination of the approach movement of the platen 12 which occurs either by contact between the knife and the pad 16 or by tripping of a lower stroke limit switch 62. To this end, the press further comprises control means including a control device for governing the motor 14 and actuated by a relay solenoid 22, the device comprising a valve 24, a battery 28, a valve operating coil 30 and contacts 32 normally open to bias the governing device to de-actuated condition for returning the platen 12 to a rest position, the control means also including an electrical control circuit comprising a trip switch arrangement, e.g. a manually operable trip switch 40, a capacitor 42 which, when sufficiently charged, energizes the solenoid 22 to actuate the control device in response to closure of the switch 40, a normally conducting switching device 44, a source of electrical energy comprising a rectifier bridge 50 supplied from the secondary of a power transformer 52, resistors 58, 60, limit switch 62, a resistor 68 and rectifiers 76, 78. While the source is loaded by the resistor 68 either by operation of the circuit or by closure of the switch 62, the voltage at the junction of the resistors 58, 60 is reduced to a value insufficient to charge the capacitor 42 for initiating the control device. If the load has been imposed by the firing of the rectifiers 76, 78 it will remain open until the circuit including the rectifiers is opened by opening the switch 40. Where, on the other hand, the load has been imposed on the source by operation of the switch 62, it will be relieved as soon as the switch is re-opened, but if the switch 40 is still held closed, the load will be transferred from the resistor 68 to the solenoid 22 by reason of conduction of the transistor 44 before sufficient charge has been built up on the capacitor 42 to cause the solenoid to initiate the control device. Therefore, again the switch 40 must be released for a charging period before re-actuation can be effected.
Patent GB-1228527-A (GB)
IPC: C08G77/08
Filed: 1969-04-09
Abstract: 1,228,527. Coated materials. SHINETSU CHEMICAL CO. 9 April, 1969 [9 April, 1968], No. 18303/69. Heading B2E. [Also in Division C3] Surfaces of glass, wood, metals (e.g. iron, aluminium and metal moulds) synthetic resins, (e.g. PVC) urea or melamine decorated boards are coated with organopolysiloxane emulsions which are prepared by forming an emulsion of an organopolysiloxane of average general formula: RaSiO 4-a  (R is an optionally substi-   tuted hydrocarbon radical and a=1-3) in water with a salt form anionic surfactant. The emulsion is then contacted with an acid form cationic surfactant which ion exchanges with the anionic surfactant to convert it to the acid form and lower the pH of the emulsion to <4 which causes the organosiloxane to polymerise, e.g. at 15-90‹C. The resultant emulsions may be cross-linked, e.g. with dibutyl tin dioctoate.
Patent GB-1228913-A (GB)
IPC: H03B5/12
Filed: 1968-05-02
Abstract: 1,228,913. Keying oscillators. INSTITUT FRANCAIS DU PETROLE DES CARBURANTS ET LUBRIFIANTS. 2 May, 1968 [2 May, 1967], No. 20849/68. Headings H3R and H3T. An oscillator comprises a transistor having a decoupling capacitor in its emitter circuit, and a two-valued signal applied to its base which upon switching to the second value initiates oscillations in a resonant circuit connected to the collector, the oscillations being sustained by a feedback circuit mainly constituted of the internal base/collector capacitance. In Fig. 5 a device, P, changes the base voltage of transistor T from its "rest" value V 1 , to a lower value V 2 , causing the resonant circuit L, C, R to produce an oscillatory output across S1, S2. The resistor R1 in the emitter circuit of T has a decoupling capacitor across it and has a value ##L/C. Base voltage V 2  is sufficient to cause the emitter threshold current to flow, while the oscillations are maintained by the main feedback path via the base-collector internal capacitance and by a supplementary feedback path via transistor T<SP>1</SP>. This latter feedback path may be omitted (Fig. 3, not shown).
Patent GB-1230993-A (GB)
IPC: A43D11/01
Filed: 1967-08-31
Abstract: 1,230,993. Coating apparatus. BRITISH UNITED SHOE MACHINERY CO. 30 Aug., 1968 [31 Aug., 1967], No. 39772/67. Addition to 1,096,792. Heading B2L. The machine of the parent specification for applying molten thermoplastic material to a shoe upper component and comprising a work support having a portion of outline shape corresponding to the portion of the component to be coated, means co-operating with the work support for clamping a component therebetween with said portion of the component exposed, an applicator device, and means whereby relative movement between the work support and the applicator device can take place in such a manner that molten material is spread over said exposed portion, is modified by providing a member adapted to apply pressure to said spread material before the component is removed from the work support. A component is clamped between a resilient pad 102, fixed to a carriage 22, and a movable plate 120. Carriage 22 is then shifted first leftwards to bring the exposed surface of the component into engagement with a driven applicator roller journalled in a casing 19, and then rightwards to its original position. A chilled block 728 then descends to apply pressure to the coating spread on the component. Block 728 is covered on top and sides by insulation 732, and is formed with interconnected transverse bores 739, 741 connected by pipes 744 to a source of refrigerant. Block 728 is pivoted about a horizontal pin 726 to the lower end of the piston rod 729 of a double-acting air cylinder 714. A plate 718, rigid with piston rod 729, carries an upstanding rod 720 slidable in a fixed bracket 710 to prevent rotation of piston rod 729. A spring 734, interposed between plate 718 and block 728 at one side of pin 726, biases block 728 against a screwed stud 738, adjustably carried by plate 718 at the other side of pin 726, for ensuring parallel engagement between the undersurface 730 of block 728 and the coated component.
Patent GB-1238108-A (GB)
IPC: D06F95/00
Filed: 1969-09-08
Abstract: 1,238,108. Washing machines. G. A. BRAUN Inc. 8 Sept., 1969 [12 Nov., 1968], No. 44260/69. Heading D1A. A laundry installation comprises a washing and water extracting machine with an air tight casing 52 and loading and unloading doors 28 and 30 in separate loading and unloading rooms 24 and 26 which are separated by a partition in which' the casing 52 is disposed, at least one of the doors being maintained closed at all times by an interlock, the loading room having an exhaust fan 40 for maintaining sub-atmospheric pressure therein, an air duct 32 connecting the casing with air outside the rooms and port means in the casing opening into the loading room. The port means comprises an air duct 34 which may be capped and a water dump valve 55 which is open except during a washing operation and so open before the un- 'loading door is opened to ensure that the casing is at below atmospheric pressure.