Patent ES-8406406-A1 (ES)
Title: Temp. control in exothermic, heterogeneous Friedel Crafts reaction
IPC: C07C13/39
Filed: 1983-04-22
Abstract: EP--89207 A Prodn. of indane, tetralin, and phenyl alcohol derivs. comprises heterogeneous Friedel-Crafts reaction of an aromatic starting material in a solvent which is cooled so as to avoid by-prod. formation. The new feature is that cooling is provided (and overheating prevented) at least mainly by continuously using the heat of reaction to boil off solvent. - A pref. process is reaction of cpds. (I) with ethylene and propylene oxide at below 20 deg.C to give alcohols (II) (Q is H in EPAB- EP--89207 B Prodn. of indane, tetralin, and phenyl alcohol derivs. comprises heterogeneous Friedel-Crafts reaction of an aromatic starting material in a solvent which is cooled so as to avoid by-prod. formation. The new feature is that cooling is provided (and overheating prevented) at least mainly by continuously using the heat of reaction to boil off solvent. - A pref. process is reaction of cpds. (I) with ethylene and propylene oxide at below 20 deg.C to give alcohols (II) (Q is H in - EP--89207 B A process for reacting a starting aromatic compound with a Friedel Crafts reactant to form an end product selected from indanes, tetralins and phenyl alcohols by a heterogeneous exothermic Friedel Craft reaction in a reaction mixture that contains a Friedel Craft catalyst and a solvent for the reaction and that is cooled to a temperature at which substantial by-product formation is avoided, characterised in that the starting aromatic compound is selected from indanes and tetralins and the Friedel Crafts reactant is selected from ethylene oxide, propylene oxide, acetyl chloride and acetic anhydride or the starting compound is selected from benzylic halides and 1-halo-2-aryl-alkanes, wherein the halogen is chlorine or bromine, and carbonium compounds that can be formed in situ from a tertiary alkyl group substituted on an aromatic compound and the Friedel Crafts reactant is an alkene or the starting compound is selected from benzene and benzene optionally substituted by C1-4 alkyl and the Friedel Craft reactant is ethylene oxide or propylene oxide and cooling of the reaction mixture throughout the reaction is solely or mainly effected, and local over heating in the reaction mixture is substantially prevented, by continuously utilising the heat of reaction to boil solvent from the reaction mixture.  (11pp) USAB- US4515990 A Improved reaction of a starting aromatic cpd. comprises using (a) ethylene oxide or propylene oxide; (b) acetyl choride or acetic anhydride, or (c) alkene, as reactant to form an indane, tetralin or phenyl alcohol end-prod. by heterogeneous exothermic Friedel Craft reaction in a reaction mixt. contg. a catalyst and solvent, then cooling to less than 40 deg.C to avoid by-prod formation. Cooling is solely or mainly effected, and local over-heating prevented, by continuously utilising heat of reaction to boil solvent from mixt. - Reactant comprises (a) when cpd is indance, tetralin, or opt. alkyl-substd. benzene; (b) when indane or tetralin; or (c) when benzylic halide, 1-halo-2-aryl alkane, or tert. alkyl-substd. cpd.