baber/WOPTO huggingface dataset:
Patent AP-1469-A (AP)
Title: The use of 4-H-1-benzopyran-4-one derivatives as inhibitors of smooth muscle cell proliferation.
Inventor: PATTERSON WINSTON CAMPBELL
IPC: A61P9/00
Filed: 2000-01-18
Granted: 2005-09-26
Abstract: Smooth muscle cells (SMC) proliferation is a critical component of neointimal formation in many animal models of vascular injury, and in many human lesions as well. Cell cycle inhibition by gene transfer techniques can block SMC proliferation and lesion formation in many animal models, although these methods are not yet applicable to the treatment of human disease. Flavopiridol is a recently identified, potent, orally available cyclin-dependent kinase inhibitor. Given the role of smooth muscle cell (SMC) proliferation in vascular disease, we tested the effects of flavopiridol, a recently identified cyclin-dependent kinase inhibitor, on SMC growth in vitro and in vivo. Flavopiridol (75 nmol/L) potently blocked SMC proliferation, an effect that was associated with downregulation of cyclin-dependent kinase activity and cell cycle-related gene expression. We examined the effects of flavopiridol on SMC proliferation in vivo in the rat carotid injury model. Flavopiridol (5 mg/kg) decreased neointimal size by 35% and 39% at 7 and 14 days, respectively, after balloon injury. Flavopiridol may be a potential therapeutic tool in the treatment of SMC-rich vascular lesions. 4-H-1-benzopyran-4-one derivatives inhibit smooth muscle cell proliferation at low dosage levels.
Patent AP-1933-A (AP)
Title: Cartridge shell and cartridge for blast holes and method of use.
Inventor: TOTA EDWARD
IPC: F42D1/08
Filed: 2001-02-22
Granted: 2009-01-05
Abstract: A cartridge shell 10 comprises a main body 12 defining a volume for holding energetic material. The main body 12 has a first end 16 for location adjacent a toe 48 of hole 46 and a second end 18 directed to the collar 50 of hole 46. This second end 18 is tapered to reduce in transverse area away from the first end to form a point or wedge-like member 20.
Patent DO-P2006000125-A (DO)
Title: Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia
Inventor: BLACKABY WESLEY PETER
Filed: 2006-06-05
Abstract: La presente invencion proporciona compuestos de la fórmula I: en los que R' es un grupo alquilo, fenilo, heterociclilo, cicloalquilo, alcoxi, ester, amino o amida; R2 es un grupo fenilo, heterociclilo, alquilo, cicloalquilo o cicloalquilalquilo; R3 es un grupo alquilo, cicloalquilo, cicloalquilalquilo, amino o heterociclilo; R4 y R5 son hidrogeno o alquilo o forman un anillo cicloalquilo; A es 0 o N;y m es cero o uno; como inhibidores de G1yTI y asi como utiles para tratar o prevenir enfermedades tales como esquizofrenia; proporcionando composiciones farmaceuticas, usos medicos primero y segundo y procedimientos de tratamiento.
Patent EG-25710-A (EG)
Title: Glaze compositions
Inventor: COOK SIMON GREGSON
IPC: C03B1/02
Filed: 2008-08-05
Granted: 2012-05-30
Abstract: This invention relates to boron-containing compositions for use in glaze compositions. There is provided a boron-containing composition for use in glaze production, which composition is obtainable by a process which comprises heating to a temperature sufficiently high that calcination occurs but insufficient for the formation of a homogeneous melt a mixture comprising components capable, under the conditions of heating, of forming the oxides B2O3, SiO2, Al2O3, Na2O and optionally CaO in proportions such that the relative percentages by weight of the said oxides, based on the total weight of the said oxides, are as follows: 10 to 18% B2O3, 40 to 65% SiO2, 17 to 32% Al2O3, 4 to 9% Na2O, and 0 to 10% CaO. The boron-containing compositions according to the present invention may be used in glaze compositions, suitably frit-free or boron-free frit-containing glaze compositions.
Patent GB-189702096-A (GB)
Title: Machinery for the Manufacture of Heel-irons for Boots and Shoes.
Filed: 1897-01-26
Granted: 1897-03-20
Abstract: 2096. Abel, C. D., [Bulius S÷hne, F.]. Jan. 26. Making parts of boots and shoes.-The rod a, of the section shown in Fig. 10, from which heel irons are to be made, is drawn from a reel through a roller straightening-device by a feed-apparatus C, C' which passes the rod through guiderollers d<5> and a grooved die e against a stop e<1>. The feedlevers C, C<1> are pivoted at c and carry chisels c' pressed by springs to grip the rod a against fixed blocks c<2>. The slide with the lever C<1> is reciprocated by suitable link mechanism from the driving-mechanism of the machine, the bar a being gripped and fed forward during the advance of the slide c<3> and prevented from being drawn back during the return of the slide by the chisel in the lever C holding the bar stationary. A length, cut from the bar a by a cutter e<3> secured in a slide E, falls down inclined surfaces 1 against two curved stops e<4>, between which it is forced by the advance of a slide H carrying a top plate h with a lower plate h<1> round which the bar is bent. The slide H is actuated from the slide E by links G and toggle-levers g pivoted to fixed supports g<1> and to pins g<2> on the slide H. The blank is carried by the plates h, h<1> over a die i, and is further bent round the plate h<1> by the dies I closed on the blank by the cam surfaces h<2> acting on the rollers i<3> on the levers i<1>. As the slide H advances, a cross-bar K coming in contact with a spring q moves in slots l of the uprights l<1> to be engaged by spring catches m. Holes are formed in the blank by punches 2, the size, number, and factory mark are imprinted in the blank by punches 3, and the ends of the iron are trimmed by the cutters 4 carried by the slide E. The die i is recessed so that the cutters 4 bend as well as trim the edges, leaving the iron with projecting ends. During the return of the slide H, the iron is pushed out of the die i by a stripper k carried by the cross-bar K which is moved with the slide H till the pivoted catches m are thrown down by their ends m<1> moving up inclines n. The movement of the cross-bar K is arrested by stops n<1>. The removal of the heel iron from the plate h<1> can be effected by the short chisel-edged arm of a lever p actuated by a stop p<1> on the slide H.
Patent GB-189716289-A (GB)
Title: Improvements in the Manufacture of Pockets for Cigarettes and the like, and in Apparatus therefor.
Inventor: DAVIDSON JOHN
Filed: 1897-07-09
Granted: 1898-06-25
Abstract: 16,289. Duthie, J., and Davidson, A., [Executors of Davidson, J.], and Murray, W. S. July 9. Cigarette cases.-Consists of a machine for forming paper pockets or cases open at one end and closed at the other for cigarettes &c. Rectangular paper blanks b, Fig. 16, are piled in an open box a, and are gummed at the edges by blades d which are alternately pressed against the gumming-rollers c<1> and the edges of the paper blanks. A pneumatic finger g, acting by exhaust through the pipe g<3>, picks up the blank and carries it to the rear, when a plunger k descends on it and forces it through a slot so as to fold it in two. Curved guides at the sides turn in the edges, which adhere together, and the case is passed down by the friction of rubber bands n to the discharging-belt o.
Patent GB-189716440-A (GB)
Title: Improvements in Metal Tubing and Methods of Making same.
Inventor: TAYLOR JOHN HENRY
Filed: 1897-07-12
Granted: 1898-06-11
Abstract: 16,440. Taylor, J. H., and Wasdell, E. C. July 12. Metal tubes.-A lap-jointed tube is made, as shown in Fig. 1, by bending one edge into Z shape and inserting the plain edge into the groove so formed. The folds are compressed together and the joint brazed. Modifications are shown. In the case shown in Fig. 4 a separate strip is used.
Patent GB-189720949-A (GB)
Title: Improvements in Photographic Shutters.
Filed: 1897-09-11
Granted: 1898-07-30
Abstract: 20,949. Eastman Photographic Materials Co., [Brownell, F. A.]. Sept. 11. Shutters.-Relates to a shutter for time or instantaneous exposures, which is set and released by one movement. The shutter consists of an oscillatory disc 2, turning on a pivot 3, and having an exposure aperture 4 capable of passing in front - of the lens opening 5. To make an instantaneous exposure, the sliding piece 20 is pressed down, whereupon a spring latch 23 attached to the sliding piece puts the actuating-spring 13 under tension by turning the cam 14 ; a flange 24 on the sliding piece meanwhile holds the shutter fixed by coming in front of the stop 8. When the flange 24 passes below the stop 8, the shutter is released. At the next exposure, the shutter is moved. in a similar manner in the opposite direction. For time exposures, the sliding piece 20 is pressed down, by a lever 30 to which it is connected, but a projection 33 on this lever stops the shutter when open, by coming in front of the spot 11. When the lever 30 is released, the stop 11 is also released, but another stop 7' is immediately caught by the flange 24 and the shutter is thereby held open until the lever 30 is pressed down at the end of the exposure. In a modification, a lever is used for the slide 20, and the lever 30 is placed above the shutter disc.
Patent GB-189722628-A (GB)
Title: Improvements in Lids or Covers for Jugs and other Vessels.
Inventor: EAST LEWIS FINDLAY
Filed: 1897-10-02
Granted: 1897-12-11
Abstract: 22,628. East, L. F. Oct. 2. Jugs.-Relates to covers for jugs or other vessels for claret, hot water, milk, &c. The cover is detachable, being kept in place by a spring A, Fig. 1, attached to a socket B on the underside of the cover C. The spring is bent at F, G to grip the edges of the vessel, and the ends H are arranged to be compressed from the outside to release the cover. In the form shown the ends are attached to a lever I, operated by a knob J on the outside but the ends may be passed out under the cover and provided with terminal knobs, which are simultaneously pressed to release the cover. A lip D is pivoted to the cover C, and a lug K on it is connected by a link L with a weighted arm K<1>, pivoted on the socket, B. The lip is thus opened by tilting the vessel, and, by making the operative length of the arm K' greater than that of the lug K, the lip may be raised above the horizontal position when pouring.
Patent GB-189724509-A (GB)
Title: Improvements in Studs for Boots, Shoes, and other similar articles.
Inventor: PAGE MATTHEW
Filed: 1897-10-22
Granted: 1898-02-26
Abstract: 24,509. Page, M. Oct. 22. Nails or studs for boots &c. have one or more pins, points, or teeth a', which are forced through the outer sole and either clinched or then forced into the inner sole. The Figures show three forms, the end a being tubular in each case. The tubular part may be split longitudinally.
Patent GB-189727803-A (GB)
Title: A Jug Strainer, to be Made in Metal to apply to any kind of Jug.
Inventor: EDWARDS WILLIAM
Filed: 1897-11-26
Granted: 1898-10-15
Abstract: 27,803. Edwards, W. Nov. 26. Jugs.-A perforated metal or wire-gauze strainer a is attached to a jug by hooks b<2> which serve to keep it in position at the spout to strain the liquid whilst being poured.
Patent GB-189802138-A (GB)
Title: Improvements in the Trimming Mechanism of Linotype Machines.
Filed: 1898-01-27
Granted: 1899-01-27
Abstract: 2138. Linotype Co., [National Typographic Co.]. Jan. 27. Linotype machines.-Relates to the trimming-mechanism, and is described as applied to the Mergenthaler machine (Specification No. 14,582, A.D. 1890). The movable knife N<6>, Fig. 3, is adjustable to and from the fixed knife N<5> by means of a sliding wedge P<15> engaging the knife N<6> on one side and inclines P<13> on the knife block P on the other side. The wedge is moved by a lever P<29> pivoted on a stud P<21>, and is locked by a spring bolt P<23> engaging notches in the wedge. The bolt is moved by a pin P<26>. The inclines <p13> may be provided with screws P<19> against the ends of which the wedge bears. A spring presses the knife N<6> against the wedge P<15>. The trimmed linotype passes through a port, one side of which is formed by a spring plate N<108> mounted loosely on the knife block as described in Specification No. 12,213, A.D. 1897. On the plate N<108> are fixed lugs N<114> engaging notches N<115> in the knife N<6>.
Patent GB-189807548-A (GB)
Title: Rail Joint.
Inventor: BROMHEAD SAMUEL SIDNEY
Filed: 1898-03-29
Granted: 1898-05-07
Abstract: 7548. Bromhead, S. S., [Keithley, H. R.]. March 29. Forging.-A. rail joint is made with a shoe of U section which is forged hot to fit over the foot, web, and head or any part of the rail ends as in Fig. 4. The shoe may have flanges at its ends or elsewhere, and fish-bolts may be used in addition. A strip of soft metal, such as copper, may be placed in the shoe before it is forged to bond the rails electrically. Two forms of presses are described for making the joint. In that shown in Fig. 1, the shoe is held in position by a detachable frame 35, which is lifted by a ram 40, and then the sides are pressed into shape by dies carried by the rams 14, 15. In the other form, a screw replaces the top ram 40.
Patent GB-189808455-A (GB)
Title: Improved Wood Paving for Streets, and the like and an Improved Block therefor.
Inventor: GRACE THOMAS
Filed: 1898-04-09
Granted: 1898-05-14
Abstract: 8455. Grace, T. April 9. Paving-blocks.-Inclined wood blocks A are obtained by cutting blocks of double the required height along the dotted lines a, a, Fig; 1. These blocks, when laid, form recesses for receiving a top dressing D of asphalt, or other composition.
Patent GB-189813145-A (GB)
Title: Improvements in Transporting Passengers and Goods from a Stationary to a Moving Stage or the like and vice versa.
Inventor: VIETOR ALWIN
Filed: 1898-06-11
Granted: 1899-06-10
Abstract: 13,145. Vietor, A. June 11. Railway platforms.-Relates to improvements in means for transporting passengers and goods from a stationary to a moving stage or the like and vice versÔ, and, in particular, is applicable to merry-gorounds, elevated railways, and the delivery of mails to trains. Fig. 1 shows diagrammatically the principle of the invention, and Fig. 4 the arrangement in plan where straight platforms are in use. To effect a transport from the stationary platform A to the moving stage C, a table such as B is rotated upon its axis about the circular path formed by the stationary platform, with the result that a point such as b<8> in contact with the platform is moving, when the position c<8> is reached, at the same rate as the moving stage C, the transport of passengers or goods being then effected. When the platforms are straight, as in Fig. 4, two tables B<1>, B<2> are connected by a rod S, and are so operated that their peripheries roll upon the edges of the platforms. Upon a second rod T, the ends of which are mounted upon pins on the tables, seats are placed. Substantially this arrangement is provided when, as in elevated railways, the platforms are superposed. In all cases, suitable means must be provided that the tables are moving relatively in the same directions as the moving platforms. In the case of merry-go-rounds, passengers pass up and down stairs in the middle of the stationary stage. Instead of a single disc, a chain passing round two discs and carrying seats is employed for transferring the passengers. A similar arrangement is also used where one disc is insufficient for the traffic.
Patent GB-189814797-A (GB)
Title: Improvements in and relating to Rotary Steam Engines.
Inventor: CHAPMAN JOSEPH CRAWHALL
Filed: 1898-07-05
Granted: 1899-04-29
Abstract: 14,797. Chapman, J. C., [Howe, M. van B.]. July 5. Annular-chamber type.-Steam entering by a hollow shaft B, a hollow drum C, and valvecontrolled ports 10 acts between pivoted vanes 11, Fig. 1, and sliding abutments 12, which are kept in engagement with the drum by spring dash-pots 15. Exhaust takes place through ports 16. The drum C acts as an inner steam-chest, and an outer steam-chest E may be provided. In a modification, the outer surface of the drum is cylindrical, and the sliding-abutments are replaced by fixed abutments. Figs. 3 and 4 show a modification, in which the abutments 12 are operated by pistons 30 working in casings 31 sliding in cylinders 32, which communicate as shown with steam-chests 33. The spindles of the valves 34 are connected to wheels 35 gearing with a spring-actuated wheel 36 by which the valves are normally closed. The valves are opened by tappets 38 engaging a governorcontrolled plate 39. Figs. 5 and 6 show means for securing a tight joint between the casing A and the drum ; in Fig. 5 a single packing-ring 43 is used, while in Fig. 6 a loose packing-ring 42 is situated between two packing-rings 40 and 41, the former being carried by the casing and the latter by the drum.
Patent GB-189817246-A (GB)
Title: Improvements in or relating to Motor Cars.
Inventor: SCHEU WILLIAM
Filed: 1898-08-10
Granted: 1899-06-24
Abstract: 17,246. Scheu, W. Aug. 10. Motor road vehicles.-Relates both to the steering and driving gear of motor cars. The car has wheels A, one on each side, at the centre, and front and rear wheels B, C, each of which is a driving and steering wheel. The front wheel B is shown as driven by toothed gearing V, and the rear wheel by a chain T, both deriving motion from skew-wheels R. The wheels R are driven from a shaft N through bevel gear. For steering purposes, the frames D through the medium of which the vehicle rests on the wheel axles are made capable of being rotated by worm gear A, B', F. The vehicle frame has roller bearings on the frames D formed by conical casings G fitted with rollers, and supporting at the centre the bevel and skew driving-gear.
Patent GB-189818705-A (GB)
Title: Improved Means for Signalling on and Stopping Railway Engines and Trains.
Inventor: FAIRLEY JOHN
Filed: 1898-09-01
Granted: 1899-07-08
Abstract: 18,705. Fairley, J. Sept. 1. Brakes.-A platform C, E, weighted at the end, is pivoted on a support B close to the rails, and is connected to the ordinary signals, points, crossing-gates, &c. so that, when the line is clear, the platform is horizontal and inoperative, but, when the line is obstructed, the platform is tilted into the position shown in dotted lines. In the latter position, it is adapted to trip a lever A on the engine, and so, through suitable connecting-levers &c., to sound the whistle, shut off steam, or apply the brakes. The apparatus may also be used for the protection of platelayers, or broken-down trains, or for stopping runaway engines &c.
Patent GB-189819311-A (GB)
Title: Improvements in and relating to Steam Boilers.
Inventor: WATSON GEORGE HERBERT
Filed: 1898-09-10
Granted: 1898-11-12
Abstract: 19,311. Watson, G. H., and Noble, E. J. Sept. 10. Water-circulation, promoting. - Water tubes 4, connecting the upper and lower portions of the water space, are fitted in the furnace flue of a return-tube boiler, passing from the front to the back. Instead of being arranged as shown, the tubes may be connected at their front ends, which are secured in a header 5, to the upper part of the boiler, and at their rear ends to the lower part ; or some may be connected in this way and others in the manner shown. The rear ends are preferably provided with flanged joints. The header is provided with covered openings, for cleaning purposes, opposite the ends of the tubes. A boiler so constructed constitutes, in effect, a combined watertube and 'Scotch' boiler.
Patent GB-189823956-A (GB)
Title: A New or Improved Hat Fastener.
Inventor: DASHWOOD EDITH
Filed: 1898-11-14
Granted: 1899-02-25
Abstract: 23,956. Dashwood, E. Nov. 14. Pins.-The point of the hat pin C is passed into the pear-shaped protector B ornamented by a stone A. The pin is retained by a lining of cork in the protector and by the ring E and spiral wire D through which it passes. The pin may be slotted to receive a cottar pin F, which secures it when passed through the hat. The cottar pin is attached to a chain I, and is held in place by a weighted flap G, Fig. 2, hinged or otherwise attached to it and suitably ornamented. Instead of a slotted pin, an ordinary pin may be used, in which case it is secured by a screw fastening, Fig. 4, ornamented by a stone M. According to another modification, the fastening is dispensed with, and a stone is mounted on the ring E at the end of the spiral wire D.
Patent GB-189827392-A (GB)
Title: Method of and Means for Manufacturing Toothed Wheels, Spoke or Disc Wheels, and similar Articles of Wrought Iron or Steel.
Inventor: EHRHARDT HEINRICH
Filed: 1898-12-28
Granted: 1899-11-04
Abstract: 27,392. Ehrhardt, H. Dec. 28. Forging.-Toothed wheels, spoke or disc wheels, or similar articles of iron or steel are made by pressing a blank a, Fig. 1, into a matrix M by means of a die having a number of sectors d radially adjustable simultaneously by screws s after the manner of chuck jaws. The nave portion is first formed as indicated in dotted lines in Fig. 1, the hole being drifted by a plunger P<1>. The sectors are then successively set out and the die slightly rotated to gradually produce the disc wheel shown in Fig. 5. If spokes are to be produced, suitable recesses are formed either in the matrix or in the sectors.
Patent GB-189902479-A (GB)
Title: Improved Appliance for Adjusting the Discs of Knife Cleaning Machines.
Inventor: SPONG JAMES OSBORN
Filed: 1899-02-03
Granted: 1899-12-16
Abstract: 2479. Spong, J. O. Feb. 3. Mounting and securing wheels on shafts. - The wear of the discs in a rotary knife-cleaning machine is taken up from time to time by means of a double-headed key D in the keyway B of the spindle A and a cam collar E on the spindle between one disc and one head D of the key. The collar is turned to take up the wear, and is secured in its new position by a set-screw R working in a groove S in the spindle.
Patent GB-189903014-A (GB)
Title: Improvements in Ploughs for Agricultural and Horticultural Purposes.
Inventor: LUCA GIUSEPPE VICENZO DE
Filed: 1899-02-10
Granted: 1900-01-20
Abstract: 3014. Luca, G. V. de. Feb. 10. Ploughs.-Relates to the construction of a plough adapted for horse or manual power. The frame A is made in two parts adjustable round a bolt a<3> and secured at each side by bolts a<4>. The frame is carried on a front steering-wheel b, an adjustable furrow-wheel C, and a driving-wheel D. The coulter H is secured by a strap h<1> and an adjustable support or rest h<2>. The share G is helical, and is mounted at the front end in a bearing h in the back of the coulter H, and at the rear end the share G is carried by a shaft g mounted in an adjustable frame F and driven by suitable gearing from the axle d of the wheel D. In Fig. 2 the gearing shown consists of bevel gearing, but a modification is described in which chain gearing is employed.
Patent GB-189904996-A (GB)
Title: Improvements in Filtering Apparatus.
Filed: 1899-03-07
Granted: 1900-01-27
Abstract: 4996. Lake, H. H., [Allgemeine Stõdtereinigungs-gesellschaft, mit beschrõnkter Haftung]. March 7. Rotary filters.-A filtering-apparatus for liquids is shown in Fig. 1. The barrel a arranged within the reservoir revolves and serves to receive the filtering-material, such as sand. The liquid, after filtering, passes into the tubular chamber c, and is discharged through the hollow trunnion z. When the tubular chamber and the barrel are coaxial, the upper part of the chamber c is left unperforated.