baber/WOPTO huggingface dataset:
Patent PT-869942-E (PT)
Inventor: CLADER JOHN W
IPC: C07D205/08
Filed: 1995-12-18
Abstract: 4-[(Heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinone hypocholesterolemic agents of the formula    <IMAGE>  I  or a pharmaceutically acceptable salt thereof, wherein: A is optionally substituted heterocycloalkyl, heteroaryl, benzofused heterocycloalkyl, or benzofused heteroaryl; Ar1 and Ar2 are optionally substituted aryl; Q is a bond or, with the 3-position ring carbon of the azetidinone, forms a spiro group; and R1 is alkylene; alkylene wherein a carbon in the chain is replaced by -O-, -C(O)-, phenylene, -NR8-, -S(O)0-2- or cycloalkylene; or alkenylene; or, when Q is a bond, R1 can be alkylene substituted by one or two hydroxy groups or hydroxy derivatives, wherein the alkylene chain can optionally be joined to Ar1 through -O- or -S(O)0-2- or joined to the azetidinone ring through a -S(O)0-2- group; a method of lowering serum cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a substituted azetidinone and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.
Patent PT-815122-E (PT)
Inventor: AALTONEN OLLI
IPC: C07K1/16
Filed: 1996-03-01
Abstract: PCT No. PCT/FI96/00120 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/27607 PCT Pub. Date Sep. 12, 1996A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin forms and other substances prepared by fermentation. The process comprises feeding a mixture containing a desired form of cyclosporin with an eluent consisting of high pressure carbon dioxide and an adjuvant, into a chromatography column being packed with particles prepared of silica, and recovering from the eluent flow coming out of the chromatography column a fraction which contains the desired cyclosporin form in adequately pure form.
Patent PT-873341-E (PT)
Inventor: HOFLE GERHARD
IPC: A61K31/00
Filed: 1996-11-18
Abstract: Epothilone derivatives of formula (I)-(III) are new. R = H or 1-4C alkyl; Y Z = H, halo, pseudohalogen, OH, 1-6C acyloxy, 1-6C alkoxy or benzoyloxy; or Y+Z = bond or O; (a) R' = Q; A = H; B = OR1; and R" = R2; or R"+B = C(O)O, C(S)O, S(O)O, Si(R")2O or C(R")(R"')O; (b) R' = C(=X)Me or CH(OX')Me; A = H; B = OR1; and R" = R2; (c) R' = Q; and A+B = bond; X = O, NOR4, N-NR4R5 or N-NHCONR4R5; X' = H, 1-18C alkyl, 1-18C acyl, benzyl, benzoyl or cinnamoyl; Q = a group of formula (i); and R1-R5 = H, 1-6C alkyl, 1-6C acyl, benzoyl, 1-4C trialkylsilyl, or benzyl or phenyl (both optionally substituted by 1-6C alkoxy, 6C alkyl, OH and halo); or R4+R5 = 2-6C alkylene. Epothilone A and B are excluded. Also claimed is the production of epothilone A or B and/or their 12,13-bis-epi derivatives comprising the epoxidation of epothilone C (for A or derivatives) or D (for B or derivatives) especially using dimethyldioxirane or a peracid.
Patent PT-849298-E (PT)
Inventor: BOCK MANFRED
IPC: C08G18/08
Filed: 1997-12-08
Abstract: Light-fast coating materials (I), consisting of cosolvent- free, aqueous, anionic dispersions of polyurethane-polyureas (PUR), in which the solid component contains the reaction product (at least partly in salt form) of (a) an NCO prepolymer derived from (i) 20-60 wt% aliphatic and/or cycloaliphatic di-isocyanate, (ii) 20-60 wt% macrodiol(s) with a mol. wt. of 500-10,000, (iii) 2-12 wt% 2,2-bis-hydroxymethyl-mono-alkanoic acid, preferably dimethylolpropionic acid (DMPA), (iv) 0-15 wt% short-chain diols with a mol. wt. of 62-400 and (v) 0-10 wt% monofunctional alcohols with a mol. wt., of 32-350 as chain regulators, (b) 0-15 wt% diamines with a mol. wt. of 60-300 as chain extenders, (c) 0-10 wt% monoamine, alkanolamine or ammonia as chain regulators, (d) 0-3 wt% water and (e) 0.1-10 wt% neutralising agent. The reaction in the prepolymer stage (a) is taken to 65-85 (preferably 75-80) % of the calculated NCO content. Also claimed is (1) a process for the production of (I) as above, in which stage (a) is carried out at 5-150 (preferably 50-110) degrees C in presence of inert solvent with a boiling range of 50-100 degrees C, preferably acetone, the amount of water added (d) is 0-30 wt% based on solids, more water is added with the neutralising agent (e), and the solvent is removed after the reaction by distillation, optionally under reduced pressure; (2) waterproof, transparent coatings of (I) which are resistant to tearing, UV, temperature and organic or inorganic deposits, show good adhesion to substrates and are easily stripped off when required; (3) a process for recycling used, stripped coatings of paint (I), by optionally cleaning, mechanically pulverising, dissolving (optionally with heating) in acetone, water and neutralising agent (preferably ammonia), and distilling off the acetone under reduced pressure to give a reusable aqueous dispersion of (I).
Patent PT-1027680-E (PT)
Inventor: KWON LIM YOUNG
IPC: H04N19/20
Filed: 1998-04-14
Abstract: A computational graceful degradation method is disclosed using priority information in multiple objects case. The method degrades the amount of computation in different ratio every object using the priority information if computational power of a decoder does not come up to that necessary for processing encoded multimedia data as decoding the multimedia data encoded by several objects unit, the priority information being determined by an encoder for optimal graceful degradation in terms of relatively importance between respective objects.
Patent PT-1000541-E (PT)
Inventor: SKELNIK DEBRA L
IPC: A01N1/02
Filed: 1999-11-02
Abstract: A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements, and a growth factor(s) which maintains and enhances the preservation of eye tissues, including human corneal, retinal and corneal epithelial tissues at low to physiological temperatures (2 DEG C to 38 DEG C). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s),a deturgescent agent(s), an energy source(s), a buffer system(s),an antioxidant(s), membrane stabilizing agents, an antibiotic(s) and/or antimycotic agent(s), ATP or energy precursors, nutrient cell supplements, coenzymes and enzyme supplements, nucleotide precursors, hormonal supplements, non-essential amino acids, trace minerals, trace elements and a growth factor(s). <IMAGE>
Patent CA-2300818-F (CA)
Inventor: O'HALLORAN MICHAEL L
IPC: A01D43/06
Filed: 1999-08-31
Granted: 2000-03-23
Abstract: A mower conditioner includes a rotary style cutter bed and a pair of laterally extending crop conditioning rolls spaced rearwardly from the cutter bed. Crop flow is improved in the machine by a laterally extending conveying roller located between the cutter bed and the nip defined by the conditioning rolls. In particular, the conveying roller serves to lift cut crop up from the cutter bed and convey the crop rearwardly to the nip. This ensures that the cut crop moves in a steady stream from the cutter bed to the conditioning rolls, and thereby reduces the risk of cut crop being thrown forwardly by the cutters. A downwardly open area is preferably defined between the conveying roller and the cutter bed to provide a space through which dirt and debris can drop out of the machine. The conveying roller preferably has a rotational axis that is lower than the rotational axis of the lower conditioning roll and generally vertically aligned with the substantially planar cutting zone defined by the cutter bed.
Patent SG-97987-G (SG)
Title: Process for upgrading heavy crude oils
IPC: C10G51/00
Filed: 1987-11-04
Abstract: Heavy crudes are demetalized with low solids rejection by sequential oxidation, mild coking and deasphalting.
Patent IE-810094-L (IE)
Title: Racquet
IPC: A63B49/02
Filed: 1981-01-20
Abstract: A racquet for use in playing a simulated tennis game on a court of reduced dimensions having an area approximately one third that of a standard tennis court. The racquet has a strung weight in the range from 340 to 400 grams, a length between 480 and 500 mms, a centre of gravity between 240 and 260 mms from the head extremity of the racquet and a radius of gyration in the range from 156 to 176 mms.
Patent IE-42945-L (IE)
Title: 1-acylaminomethyl-1, 2, 3, 4-tetrahydroisoquinolines
IPC: C07D217/16
Filed: 1976-01-30
Abstract: Novel tetrahydroquinolines of the formula <IMAGE> wherein R is cycloalkyl or cycloalkenyl each containing 4-7 ring carbon atoms and the cycloalkyl optionally being substituted by one of methyl, hydroxyl or oxo; phenyl substituted by 1-2 of amino, acylamino of up to 4 carbon atoms, Hal, hydroxyl, methoxy or nitro, wherein Hal is fluorine, chlorine, bromine or iodine; thienyl; pyridyl; tetrahydropyranyl; tetrahydrothiopyranyl; and when at least one of R2, R3, R4, R5 or R6 is other than H, also phenyl; R2, R3 and R4 each are H or methyl; R5 and R6 each are H, methyl or methoxy; R7 is H or -CO-CH2-X wherein X is chlorine, bromine or iodine; the acid addition salts thereof; which compounds are useful as antihelmintics and as intermediates for the production of 2-acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline derivatives; and the corresponding compounds wherein R is alkyl of 1-6 carbon atoms, phenyl substituted by three of the substituents named above, and phenyl when all of R2, R3, R4, R5 and R6 are H; are produced by acylating the corresponding 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline wherein R7 is H, and optionally thereafter reducing the R group and/or reacting the ring nitrogen atom with an acylating group.
[US4362875A]
Patent IE-870288-L (IE)
Title: Die for extrusion of a hollow section of choclate.
IPC: B30B11/22
Filed: 1987-02-04
Abstract: An extrusion die for producing hollow extrusions from material which is difficult to solidify quickly eg chocolate, comprises an outer die part (l3) secured to the end of a supply pipe (l2). The outer die part (l3) has a central aperture (l6) within which an inner die part having a multiplicity of spaced air injectors (l7) is provided. During extrusion, chocolate is forced through the apertures (l6) and surrounds the injectors (l7) to produce an extrusion having a plurality of longitudinal passages therein. A fluid, e.g. air, is passed through the injectors (l7) and into the longitudinal passages to prevent collapse of the passages before the chocolate has set. Relative rotation between the outer and inner die parts may be effected.
Patent IE-900297-L (IE)
Title: Telecommunications system
IPC: H04W72/08
Filed: 1990-01-26
Abstract: A communication procedure suitable for a cordless telephone system involves time division duplex radio communication between a handset 11 and a base station 3 using alternating bursts of transmission over a single radio channel. Once a radio link has been set up, initial transmissions carry a synchronisation logical channel S and a signalling logical channel D multiplexed together, but the link may switch to bursts carrying a communications logical channel B for the speech data and the signalling logical channel D. Burst synchronisation is achieved by the asynchronous detection of words in a synchronisation channel S. These words have bit patterns reducing the probability of incorrect asynchronous detection of them.   If one part ceases to receive handset signals from the other, it transmits a special signal, informing the other part. This enables both parts to detect the failure of a link at substantially the same time, so that their actions to re-establish the link are synchronised.
Patent IE-36161-L (IE)
Title: Connecting strips
IPC: A63H33/10
Filed: 1972-03-14
Abstract: 1387502 Structural joints MEUBEL FABRIEK "DECO" NV 9 March 1972 [18 March 1971] 11081/72 Heading F2M An integrally formed strip for connecting together panels has two or more panel edge receiving channels extending along the whole length of the strip and each defined by first and second side walls 2 formed with opposed projections 3 and connected by a third wall 1 of length at least twice the distance between the projections and the third wall, each channel being of symmetrical cross-section and so arranged on the strip that the third side wall 1 or the projections 3 are located in the plane of symmetry of an adjacent channel, whereby panels inserted into adjacent channels are retained at right angles to one another. As described the panels 5 are provided with grooves along their margins to mate with the channels. In addition to the strip forms shown in Figs. 2 and 4, the channel B of Fig. 4, may be closed off by a wall parallel to central wall 1 to form a cavity along the length of the strip and in each case the channel A may be omitted. As regards the Fig. 2 arrangement, the limb L may be omitted also. The strip and panels may be utilized to form compartmented cupboards using hardboard or plastics panels together with further strips (Figs. 8 to 13, not shown) including one or more channels with inturned projections 3 with or without flanges extending from the side walls 2 parallel to the walls 1. Where panels are assembled edge to edge using flanged strips, such flanges may bear an adhesive layer which initially is covered by a removable protective strip (Fig. 17, not shown).
[GB1387502A]
Patent IE-42303-L (IE)
Title: Pipette.
IPC: G01F11/06
Filed: 1976-02-26
Abstract: A mechanical pipette having a fixed stroke for aspirating and discharging a predetermined volume of liquid into and from a reservoir. A measuring piston controls the volume of liquid drawn into the reservoir and a substantially larger piston assures that all of the liquid in the reservoir is expelled therefrom on a discharge stroke. On the discharge stroke, a mechanically actuated valve is opened to admit air being compressed by the substantially larger piston into the reservoir.
[US3935734A]
Patent IE-37407-L (IE)
Title: Consolidating fleeces
IPC: D04H1/488
Filed: 1973-03-14
Abstract: 1427975 Non-woven fabrics BUNZL & BIACH AG 14 March 1973 [14 March 1972] 12200/73 Heading D1R A fleece consisting of polyolefinic fibres is consolidated by partially dissolving or swelling the fibres by impregnation with a solvent or swelling agent which is substantially saturated with a polyolefinic or polyvinylic binder. Preferably the fleece comprises staple fibres or spun bonded continuous filaments of polypropylene or polyethylene, the solvent is trichloroethylene or an aromatic hydrocarbon, the binder is polypropylene, high pressure polyethylene, polyvinyl chloride, polyvinylacetate or polyisobutylene rubber and the solution also contains a plasticiser, lampblock, graphite and/or phenylamine (as antioxidant). The fleece may be needled before the application of solvent. In the embodiments solutions of 10 to 35% binder were applied at a temperature of 43- 65C, the fleece squeezed out and dried at up to 100C. Hot calendering may be used to give an impermeable sheet.
[GB1427975A]
Patent IE-36298-L (IE)
Title: Electric cable screening paper.
IPC: H01B3/00
Filed: 1972-04-17
Abstract: 1329636 Laminated papers PIRELLI GENERAL CABLE WORKS Ltd 14 April 1972 [20 April 1971] 10245/71 Heading B5N [Also in Divisions D2 and H1] A paper for use in screening electric cables comprises a semi-conducting paper ply and an insulating paper ply of impermeability at least 20 Î 10<SP>6</SP> Emanueli units (E.U.) The semiconducting ply may be paper loaded with carbon black. The insulating ply may have an apparent density of at least 1À0 gm./cm.<SP>3</SP> and an impermeability of (20-2000) x 10<SP>6</SP> E.U. The overall apparent density and impermeability are typically 1À0-1À15 gm./cm.<SP>3</SP> and (100-300) Î 10<SP>6</SP> E.U. The thickness of each ply may be at least 0À025 mm. and the ratio of thicknesses of the plies should not exceed 1 : 3 in either sense. The overall thickness should not exceed 0À20 mm.
[GB1329636A]
Patent IE-43222-L (IE)
Title: Piperazine derivatives
IPC: C07D295/13
Filed: 1976-04-06
Abstract: 1490507 Piperazine derivatives PARCOR 6 April 1976 [7 April 1975] 13923/76 Heading C2C Novel compounds of formula where R 1 is halogen, alkyl, alkoxy or trifluoromethyl, and either R 2 and R 3 together complete a 4- to 8-membered saturated heterocyclic ring which may contain an oxygen or nitrogen atom as a second hetero atom, or R 2 is H and R 3 is cycloalkyl, and salts thereof, are prepared by reacting with B, wherein A is H and B is Hal(CH 2 ) 3 NR 2 R 3 or A is -(CH 2 ) 3 Hal and B is HNR 2 R 3 , or by condensing a cycloalkanone with an appropriate amine and reducing the resulting imine. Pharmaceutical compositions comprising the above novel compounds have hypocholesterolaemic, anti-inflammatory and analgesic activity.
[GB1490507A]
Patent IE-870840-L (IE)
Title: Metalorganic vapor phase epitaxial growth of group ii - iv¹semiconductor materials
IPC: C30B25/02
Filed: 1987-04-01
Abstract: A process to produce one or more Group II-VI epitaxial layers over a crystalline substrate by directing flows of one or more Group II components and a Group VI metalorganic vapor to a heated substrate whereby the vapors thereby react to form the epitaxial layer(s), is improved in terms of lower reaction temperatures and higher product quality if, as the Group VI metalorganic vapor source, there is used a tellurium compound of the formula: <CHEM> wherein R<1> and R<2> are, independently, hydrogen or C1-C4 alkyl, preferably, hydrogen.
[EP0240844A1]
Patent IE-890854-L (IE)
Title: Lyophilized pharmaceutical preparations
IPC: A61K47/00
Filed: 1989-03-16
Abstract: The ifosfamide-mesna lyophilisate consists essentially of ifosfamide, 0.1 - 1.0 part by weight of mesna and 0.1 to 17 parts by weight of hexitol.
Patent IE-32297-L (IE)
Title: Rotary piston hydraulic machines
IPC: F01C1/344
Filed: 1968-08-22
Abstract: 1,191,426. Rotary-piston pumps and motors. FRIED. KRUPP G.m.b.H. Aug. 30, 1968 [Sept. 2, 1967], No. 41561/68. Heading F1F. In a rotary-piston hydraulic pump, or motor, a vane 25, Fig. 3, is lodged slidably in a radial slot 24 within a housing 20 for the piston 21, which is of non-circular profile, the vane carrying spring-loaded packing-strips 28, 35 engaging with the piston and spring-loaded packing-strips 33 in the ends of the housing, respectively. Springs (not shown) or hydrostatic pressure in the slot 24 bias the vane towards the piston. The piston is situated in a cylindrical bore in the housing. The strips 28, 35 may be rendered integral with one another, Fig. 4 (not shown). Alternatively, when the vane is biased by hydrostatic pressure in the slot 24 the packing strips are loaded by said pressure, to which end bores 40, 41 are formed in the vane and packing strips 38 that replace the strips 35 and contain grooves 39 communicating with a slot 29 for the strip 28. Gaps 42 and bevels 43 hydrostatically connect the inner parts of grooves 32 for the strips 33 with the grooves 39. An arrangement of packing strips generally similar to that according to Fig. 4 may be provided for each of several axially-movable vanes 57, Fig. 7, lodged in an annular web 55 in a housing for a pair of annular members 52 fixed to a rotary shaft 50 and having sinusoidal profiles at the surfaces thereof abutting the strips 28.
[GB1191426A]
Patent IE-821219-L (IE)
Title: Frusto-conical support element
IPC: B65H75/50
Filed: 1982-05-21
Abstract: A cone-shaped bobbin is formed by rolling and gluing a paper or the like blank on a mounting mandrel with the cone being formed with a decreasing number of layers of paper or the like from bottom to top. Three embodiments of the blank are disclosed respectively in the shape of a crescent, a half-crescent, and a comma.
[US4526566A]
Patent IE-42869-L (IE)
Title: Check valve
IPC: F16K15/03
Filed: 1976-06-22
Abstract: An improvement in multi-flapper check valves wherein each flapper is urged toward closure by an independent spring or springs, thereby improving the valve response for closure.
[US4005732A]
Patent IE-37988-L (IE)
Title: Piperazinyl-substituted benzene disulphonamides.
IPC: C07D405/12
Filed: 1973-08-10
Abstract: 1437023 Benzene-1,3-disulphonamides HOECHST AG 13 Aug 1973 [12 Aug 1972 7 July 1973] 38246/73 Heading C2C [Also in Division A5] The invention comprises compounds having the general formula wherein R is C 1 to C 6 alkyl; R<SP>1</SP> and R<SP>2</SP> are hydrogen, methyl or ethyl; R<SP>3</SP> is hydrogen or C 1 to C 6 alkyl; and R<SP>4</SP> is hydrogen, optionally substituted allyl, C 1 to C 6 alkyl which may be interrupted by oxygen, sulphur, -SO-, -SO 2 - or -N-alkylthe nitrogen atom of which may be a member of a 5- or 6-membered heterocyclic ring, C 3 to C 8 cycloalkyl or cycloalkylalkyl, or aralkyl (optionally substituted by one or two halogen atoms or alkyl, alkoxy, bismethylene-oxy, or mono- or di-alkylamino groups) or 2-furylmethyl, 2-tetrahydrofurylmethyl or pyridylmethyl, or the group represents pyrrolidyl, piperidyl or morpholinyl which may be alkyl substituted, hexamethyleneimino or 4-alkyl-piperazin-1-yl. They may be prepared by (a) reacting a compound of the formula where X is halogen, alkyl or arylsulphonyloxy with an amine of the formula or (b) reacting a compound of formula with a piperazine derivative of the formula or (c) methylating a compound of Formula I in which at least one of R<SP>1</SP> to R<SP>4</SP> is hydrogen, or (d) oxidizing a compound of the Formula I in which R<SP>4</SP> is an alkyl radical interrupted by a sulphur atom or a -SO- group. The compounds of the invention exhibit hypotensive properties and may be administered by the intraduodenal and intravenous routes optionally as their physiologically tolerable salts, alone or in admixture with pharmaceutically acceptable diluents or carriers.
[GB1437023A]
Patent IE-45243-L (IE)
Title: 2,6-methano-tetrahydro-2h-1-benzoxocins
IPC: C07D311/78
Filed: 1977-07-05
Abstract: Novel 2-oxy-5-isopropylidene-7-hydroxy-9-substituted-2,6-methano-3,4,5,6-tet rahydro-2H-1-benzoxocins are prepared by condensing a 5-(substituted)resorcinol with a 1-alkoxy-4-(1-hydroxy-1-methylethyl)-1,4-cyclohexadiene in the presence of a suitable catalyst. The new benzoxocin derivatives are useful in the synthesis of certain dibenzo[b,d]pyran-9-ones, valuable as anti-anxiety, analgesic, and anti-depressant drugs.
[US4140701A]
Patent IE-39740-L (IE)
Title: Mortar composition
IPC: C04B24/16
Filed: 1974-08-16
Abstract: A mortar comprising an inorganic binder such as anhydrite, gypsum or cement is rendered more flowable and processible by incorporating therein a sulfonic acid group-containing formaldehyde condensation product with a cycloalkanone, e.g. preferably about 0.05 to 5% by weight of the binder of the condensation product of sodium sulfite, formaldehyde and cyclohexanone. There may also be present an auxiliary such as FeSO4,7 H2O,Al2(SO4)3.18 H2O or KAl(SO4)2, as well as an additive such as a plasticizer, hardening accelerator, retarder, air-entraining agent, thickener, activator, anti-foam agent or synthetic resin dispersion, and/or an aggregate such as sand, silica, perlite, pumice or foamed plastic beads.
[US3972723A]
Patent IE-801774-L (IE)
Title: Analgesic mixture
IPC: A61K31/485
Filed: 1980-08-22
Abstract: A composition consisting essentially of nalbuphine and acetylsalicyclic acid, derivative or salt thereof, gives unexpectedly enhanced analgetic activity.
[EP0024690A1]
Patent IE-891795-L (IE)
Title: Pharmaceutical compositions for piperidinoalkanol-ibuprofen¹combination
IPC: A61K31/445
Filed: 1989-06-12
Abstract: The present invention is directed to a multi-layered tablet containing an ibuprofen layer, a piperidinoalkanol antihistamine layer, and a layer or layers containing conventional pharmaceutical excipients which is interspersed between the ibuprofen and piperidinoalkanol layer and serves to physically separate them. This tablet solves the problems associated with the physical and chemical incompatibilities between ibuprofen and the piperidinoalkanol antihistamines.
[EP0348683A1]