baber/WOPTO huggingface dataset:
Patent AR-125019-A1 (AR)
Title: COMPOSICIONES DE ARNi CONTRA CETOHEXOQUINASA (KHK) Y SUS MÉTODOS DE USO
Inventor: NOETZLI LEILA
IPC: C12N15/113
Filed: 2022-02-18
Abstract: Agentes de ARNi, por ejemplo, agentes de ARNhd, contra el gen de la cetohexoquinasa (KHK). Métodos para usar dichos agentes de ARNi para inhibir la expresión de un gen KHK y métodos para tratar o prevenir un trastorno asociado con la KHK en un sujeto.  Reivindicación 1: Un agente de ácido ribonucleico de hebra doble (ARNhd) para inhibir la expresión de la cetohexoquinasa (KHK) en una célula, caracterizado porque dicho ARNhd comprende una hebra sentido y una hebra antisentido que forman una región de hebra doble, en donde la hebra antisentido comprende una región de complementariedad con un ARNm que codifica para KHK, y en donde la región de complementariedad comprende por lo menos 15 nucleótidos consecutivos que difieren en no más de 3 nucleótidos con una cualquiera de las secuencias de nucleótidos antisentido de una cualquiera de las Tablas 2, 3, 5, 6 y 8 - 13. Reivindicación 51: Un agente de ácido ribonucleico de hebra doble (ARNhd) para inhibir la expresión de cetohexoquinasa (KHK) en una célula, o una sal farmacéuticamente aceptable del mismo, caracterizado porque comprende una hebra sentido y una hebra antisentido que forman una región de hebra doble, en donde a) la secuencia de nucleótidos de la hebra sentido difiere en no más de 4 bases con respecto a la secuencia de nucleótidos 5-gscsaggaagCfAfCfugagauucgu-3 y la secuencia de nucleótidos de la hebra antisentido difiere en no más de 4 bases con respecto a la secuencia de nucleótidos 5-asdCsgadAudCucagdTgCfuuccugcsasc-3, en donde a, g, c y u son 2-O-metilo (2-OMe) A, G, C, y U; Cf y Uf son 2-desoxi-2-fluoro (2-F) C y U; dC, dA, y dT son 2-desoxi C, A, y T; y s es una unión de fosforotioato; o b) la secuencia de nucleótidos de la hebra sentido difiere en no más de 4 bases con respecto a la secuencia de nucleótidos 5-csusacggagAfCfGfugguguuugu-3 y la secuencia de nucleótidos de la hebra antisentido difiere en no más de 4 bases con respecto a la secuencia de nucleótidos 5-asdCsaadAcdAccacdGuCfuccguagscsc-3, en donde a, g, c y u son 2-O-metilo (2-OMe) A, G, C, y U; Cf y Uf son 2-desoxi-2-fluoro (2-F) C y U; dC, dA, y dG son 2-desoxi C, A, y G; y s es una unión de fosforotioato.
Patent AR-125448-A1 (AR)
Title: Moduladores de trex1
Inventor: LEVELL JULIAN R
IPC: C07D413/14
Filed: 2022-04-25
Abstract: Compuestos de fórmula (1); y sales farmacéuticamente aceptables y composiciones de los mismos, que son útiles para el tratamiento de una variedad de condiciones asociadas con la TREX1.  Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1); o una sal farmacéuticamente aceptable del mismo, donde: R¹ es halo, hidrógeno, (C₁-C₄)alquilo, o halo(C₁-C₄)alquilo; R² es hidrógeno, (C₁-C₄)alquilo, halo(C₁-C₄)alquilo, -(C₁-C₄)alquiloRᵃ, -(C₁-C₄)alquilSRᵃ, o -(C₁-C₄)alquilNRᵇRᶜ; Rᵃ se selecciona entre hidrógeno, (C₁-C₄)alquilo, halo(C₁-C₄)alquilo, -COORᵇ, y -C(O)NRᵇRᶜ; Rᵇ y Rᶜ son independientemente entre sí hidrógeno o (C₁-C₄)alquilo; R³ y R⁴ son independientemente entre sí hidrógeno, halo, (C₁-C₄)alquilo, o halo(C₁-C₄)alquilo; R⁵ es fenilo, heteroarilo de 5 a 7 miembros, o heterociclilo de 5 a 7 miembros, cada uno de los cuales está opcionalmente sustituido con entre 1 y 3 grupos seleccionados entre R⁷; R⁶ es heteroarilo de 5 a 7 miembros o heterociclilo de 5 a 7 miembros, cada uno de los cuales está opcionalmente sustituido con entre 1 y 3 grupos seleccionados entre R⁸; y R⁷ y R⁸ se seleccionan independientemente entre sí entre halo, hidroxilo, (C₁-C₄)alquilo, (C₁-C₄)deuteroalquilo, halo(C₁-C₄)alquilo, (C₁-C₄)alcoxi, halo(C₁-C₄)alcoxi, -(C₁-C₄)alquiloRᵃ, -(C₁-C₄)alquilSRᵃ, -(C₁-C₄)alquilNRᵇRᶜ, -(C₁-C₄)alquil-ciano, -(C₁-C₄)alquilC(O)NRᵇRᶜ, ciano, -[(C₁-C₄)alquil(heterociclilo de 4 a 7 miembros)], -(heterociclilo de 4 a 7 miembros), -[(C₁-C₄)alquil(C₃-C₅)cicloalquilo], -C(O)NRᵇRᶜ, -CORᵇ, y -COORᵇ, donde dichos heterociclilo de 4 a 7 miembros y (C₃-C₅)cicloalquilo están opcionalmente sustituidos en cada caso con entre 1 y 3 grupos seleccionados entre halo, (C₁-C₄)alquilo, halo(C₁-C₄)alquilo, (C₁-C₄)alcoxi, halo(C₁-C₄)alcoxi, COORᵇ, -C(O)NRᵇRᶜ, y -CORᵇ.
Patent AR-006206-A1 (AR)
Title: Método para fabricar hierro metalico, dispositivo para su fabricación y conglomerado reducido obtenido por dicho método y mediante dicho dispositivo
IPC: C21B13/00
Filed: 1997-03-13
Abstract: Un método para fabricar hierro metálico en el que un conglomerado que contiene óxido de hierro, tal como mineral de hierro o similar y un agentereductor carbonoso, tal como carbón o similar, se usa como material, y el óxido de hierro se reducea través de la aplicación de calor, fabricando de estamanera hierro metálico. En el curso de esta reducción se genera una envoltura compuesta de hierro metálico y se hace crecer sobre la superficie del compacto,y la escoria se agrega dentro de lae nvoltura. Esta reducción continúa hasta que no está presente substancialmente óxido de hierro dentro de la envoltura dehierro metálico. Posteriormente se hace el calentamiento para fundir el hierro metálico y la escoria. El hierro metálicofundid o y la escoria fundida seseparan uno del otro , obteniendo de esta manera hierro metálico con una relación de metalización relativamente grande. Por medio de un aparato parafabricar hierro metálico de la presente invención se lleva ala prácti ca eficientemente este método y se puede fabricar hierro metálico que tiene unaalta pureza de forma continua y productiva no sólo a partir del óxido de hierro que tiene un alto contenido de hierro sino también a partir de óxido dehierroque ti ene un contenido de hierro relativamente bajo.
Patent AR-009983-A1 (AR)
Title: Cobertura removible para medias.
Filed: 1997-10-15
Abstract: Se refiere a una cobertura removible para medias, consistente en un elmento laminar flexible, fijado exteriormente a las mismas, proveyendo al usuariode una proteccion que la media de por sí no logra, aumentando su durabilidad y ampliando notablemente sus posibilidades de uso.
Patent AR-015334-A1 (AR)
Title: Anticancerigeno
Filed: 1997-12-10
Abstract: Anticancerígeno que es el extracto concentrado producido por la ebulllicion o hervor en agua comun y/o destilada que se extrae de la hoja de laplanta POINCIANA GILLIESII que contiene los elementos y la constitucion celular, medicamento denominado XAMA y que cura el cáncer en el cuerpo humano.
Patent AR-015683-A1 (AR)
Title: Procedimiento para localizar y rastrear a distancia a personas, mascotas moviles, objetos, sucesos y manejar eventos
Filed: 1998-05-18
Abstract: Comprende una secuencia de etapas que se inician con la activacion de una senal, que en primer lugar, es decodificada y pone en movimiento al sistema pormedio de un software que la transmite a un lazo central radiodifusor, hacia una pluralidad de unidades remotas repetidoras, de las cuales, al menos una, estáacondicionada para realizar distintos eventos, y la retransmision hacia otra pluralidad de receptores-transmisores remotos rastreadores de la senal, desde lascuales se identifican las trazasangulares del foco de emision y se retransmiten hacia una unidad central operativa de triangulacion, desde donde se envíainformacion obtenida, a por lo menos un receptor movil. La localizacion se realiza sin necesidad de interceptar el elemento queradia la senal, ubicándolo conprecision.
Patent AR-009213-A1 (AR)
Title: Cierre de doble centro desencontrado
Filed: 1998-12-22
Abstract: En máquinas agrícolas por el cierre de doble centro desencontrado se articula y da seguridad de aplicacion al sistema mediante sus barras de cierrey de soporte formadas por estructuras tubulares de encastre simultáneo, cuyo mecanismo con barra telescopica extensible automáticamente por cilindrohidráulico ubicado debajo de ésta hace variar las posiciones y distancias de las herramientas sobre bases orientables de los fondos dosificadores desiembra segun la posicion del chasis principal y estabilizadores de alineacion de fondos.
Patent AR-019100-A1 (AR)
Title: Administracion de proteinas terapeuticas
IPC: A61P7/00
Filed: 1999-04-23
Abstract: La presente consiste en un método para la administracion de una proteína terapéutica a un mamífero introduciendo en el omento del mamífero una célulagenéticamente construida para secretar la proteína terapéutica.
Patent AR-020511-A1 (AR)
Title: Bide de comando frontal
Filed: 1999-09-23
Abstract: Bide caracterizado porque comprende comando o grifería en la parte frontal del mismo, donde cuyo cuerpo es rematado en forma de ángulo perimetraldecreciente hacia la parte posterior, con la finalidad de generar la superficie necesaria para alojar allí los comandos de apertura y cierre de agua fria ycaliente; y para que éstos, a su vez, no excedan los límites superior y frontal del cuerpo del bide.
Patent WO-2010003160-A1 (WO)
Title: Kopfhörer zur elektroakustischen wandlung eines stereosignals
Inventor: WEINGARTNER BERNHARD
IPC: H04R5/033
Filed: 2009-06-05
Abstract: Bei einem Kopfhörer zur elektroakustischen Wandlung eines Stereosignals, welches ein elektrisches Signal (Y) für den rechten Kanal und ein elektrisches Signal (X) für den linken Kanal umfasst, mit einem Hörerteil (1) für das rechte und einem Hörerteil (2) für das linke Ohr, wobei ein jeweiliges Hörerteil (1) einen Schallraum (5) aufweist, ist ein jeweiliges Hörerteil (1) mit mindestens zwei elektroakustischen Wandlern (3, 4) versehen, die in den Schallraum (5) abstrahlen und deren Schallfelder sich im Schallraum (5) mischen, wobei einem ersten der Wandler (3) des jeweiligen Hörerteils (1) das entsprechende Signal (Y, X) für den rechten bzw. linken Kanal und einem zweiten der Wandler (4) des jeweiligen Hörerteils (1) ein elektrisches Differenzsignal, welches die Differenz zwischen den Signalen (Y, X) der beiden Kanäle enthält, zugeführt wird.
Patent WO-2019178632-A1 (WO)
IPC: A01P3/00
Filed: 2019-03-22
Abstract: The invention relates to a liquid composition containing at least one polymeric guanidine and at least one wetting agent dissolved in an inorganic solvent, to the use of this composition for increasing the shelf life of harvested fruit and vegetables, or as a plant protection product against undesirable micro-organisms on the surface of harvested fruit and vegetables, and to a method for increasing the shelf life of harvested fruit and vegetables, or for combating undesirable micro-organisms, by applying this composition to the surface of harvested fruit and vegetables.
Patent AU-2002225162-A1 (AU)
Title: Production and visualisation of garments
Inventor: GARDNER JAMES HOLDEN PATRICK
IPC: A41H1/00
Filed: 2002-01-18
Abstract: Methods and systems for modelling and modifying garments, providing a basis for integrated "virtual tailoring" systems and processes. The garment models provided relate specific design points of the garment to specific body regions in terms of explicit 3D relationship rules, enabling garments to be modified holistically, by a constrained 3D warp process, to fit different body shapes/sizes, either in order to generate a range of graded sizes or made-to-measure garments, for the purposes of visualization and/or garment production. The methods described further facilitate the generation of 2D pattern pieces by flattening 3D representations of modified garments using a constrained internal energy minimization process, in a manner that ensures that the resulting pattern pieces can be assembled in substantially the same way as those of the base garment. The methods enable the visualisation and/or production of bespoke or graded garments, and garment design modifications, within an integrated virtual tailoring environment.
Patent AU-2002242004-A1 (AU)
Title: Optical detection in a multi-channel bio-separation system
Inventor: LIU MING-SUN
IPC: G01N27/447
Filed: 2002-01-28
Abstract: A multi-channel bio-separation detection method and apparatus in which a single detector is coupled to a plurality of radiation sources, in a one detector/many radiation sources configuration. Each radiation source directs radiation at one detection zone of a single separation channel, and a single detector is applied to detect light emissions from the detection zones of several separation channels. The light sources direct radiation at the detection zones in a predetermined sequence and further in a cyclic manner, with the detector output synchronized to the light sources by a controller. Bio-separation may be conducted simultaneously in all the channels in parallel, with detection time-staggered and/or time multiplexed with respect to the light sources. In one embodiment, low cost light emitting diodes may be used as light sources. In another aspect, the detection scheme is configured for radiation induced fluorescence detection in a multi-channel capillary electrophoresis instrument.
Patent AU-2002251725-A1 (AU)
Title: Compositions and methods for biomedical applications
Inventor: WALISH JOSEPH
IPC: A61L27/44
Filed: 2002-01-02
Abstract: The present invention relates to biomedical implants for bone substitution and replacement applications. The implant includes a strong, porous polymeric or thermoplastic compositions and growth-enhancing compositions.
Patent AU-2002307193-A1 (AU)
Title: Liquid distributor in mass transfer column and method of installation and use
Inventor: PETRICH TULLIO
IPC: B01D3/00
Filed: 2002-04-10
Abstract: A mass transfer column is provided with a liquid distributor that distributes liquid to an underlying mass transfer bed containing one or more random, grid or structured packing elements. The liquid distributor includes a plurality of elongated troughs that are spaced apart and extend across the column. A plurality of liquid discharge holes are positioned in side walls of the trough and are located in one or more preselected planes that are preferably spaced above a floor of the trough. Splash baffles are spaced outwardly from the trough side walls and include upper portions that are positioned to receive liquid exiting the troughs through the discharge holes. Lower portions of the splash baffles form a constricted discharge outlet in a plane below the trough for delivering liquid from the splash baffles to the underlying mass transfer bed. The liquid discharge holes in one of the trough side walls are offset from those in the other trough side wall to provide a more uniform distribution of liquid to the discharge outlet. The splash baffles are vertically adjustable and are intended to be supported on the upper surface of the mass transfer bed so that the discharged liquid is delivered directly to the mass transfer bed, thereby reducing the opportunity for the falling liquid to become entrained in a vapor stream flowing upwardly through the mass transfer bed. The liquid exiting through the discharge outlet preferably forms a curtain-like flow that blocks or impedes vapor entry upwardly into the discharge outlet. Any vapor that enters the discharge area is able to vent upwardly through the open spacing between the baffles and the associated troughs at a reduced velocity, thereby reducing the opportunity for liquid entrainment. The open spacing also permits any overflow of liquid from the troughs to be captured by the splash baffles for downward flow along the inner faces of the splash baffles.
Patent AU-2002358600-A1 (AU)
Title: Cantilever-slab connecting element and a cantilever-slab connecting assembly comprising a number of cantilever-slab connecting elements of this type
Inventor: ENZLER RUDOLF
IPC: E04B1/00
Filed: 2002-12-04
Abstract: The invention relates to a number of cantilever-slab connecting elements (1A, 1B, 1C) of a first structural type, with an insulating part (4), which is traversed by box-type tensile-force transfer members (3). An insulating material is inserted in the section (10) of each tensile-force transfer member (3) that is located in the insulating part. In addition, a box-type pressure-force transfer member (13), which comprises several cells likewise containing an insulating material, is provided in each insulating part (4). A number of cantilever-slab connecting elements (2A, 2B) of a second structural type are traversed by a reinforcing bar (84) that transfers a tensile force. The entire cantilever-slab connecting assembly has several adjacent cantilever-slab connecting elements (1A, 1B, 1C) of the first structural type and cantilever-slab connecting elements (2A, 2B) of the second structural type. Transversal force bars (85) are also provided. The latter run through the joints of adjoining insulating parts (4). The tensile-force transfer members (3) of the cantilever-slab connecting assembly (1A, 1B, 1C; 2A, 2B) are interconnected by means of transversal bars.
Patent AU-2003212716-A1 (AU)
Title: Feed for aquatic species
Inventor: KULAS ELIN
IPC: A23K1/18
Filed: 2003-03-11
Abstract: The invention relates to a feed for aquatic species and crustaceans, in particular marine species and fry thereof. The feed described comprises proteins, lipids and additional, optional components, and is characterized in that the lipids are one or more marine oils and/or vegetable oils treated by urea and/or other amines or amides, to provent degradation due to oxidation (oxidative stress).
Patent AU-2003215458-A1 (AU)
Title: System and method for visualizing fluid flow through vessels
Inventor: FLOWER ROBERT
IPC: A61B3/12
Filed: 2003-03-20
Abstract: A method for visualizing fluid flow through vessels having a visualizing composition flowing therethrough, the method comprising the steps of: selecting from a sequence of angiographic images a subsequence of angiographic images, reading a plurality of dynamic parameters, the dynamic parameters for controlling display of the angiographic images, serially displaying the subsequence repetitively in accordance with the dynamic parameters, and providing an interface for dynamic user update of the dynamic parameters while displaying the subsequence.
Patent AU-2003216793-A1 (AU)
Title: Gastric ring for the treatment of obesity
Inventor: DULUCQ JEAN LOUIS
IPC: A61F5/00
Filed: 2003-01-08
Abstract: This gastric ring ( 1 ) comprises: a band ( 3 ) defining a central portion ( 3 a) which is able to surround the wall of the stomach, and two lateral portions ( 3 b) which can be connected to one another to hold the band ( 3 ) around the stomach ( 2 ), and means ( 4 ) for connecting said lateral portions ( 3 b) to one another and for maintaining these lateral portions ( 3 b) in the connected position. According to the invention, the band ( 3 ) consists of an assembly of filaments made of a bioabsorbable material.
Patent AU-2003220344-A1 (AU)
Title: Manufacturing methods for resistance variable material cells
Inventor: CAMPBELL KRISTY A
IPC: H01L27/105
Filed: 2003-03-12
Abstract: The present invention is related to methods and apparatus to produce a memory cell or resistance variable material with improved data retention characteristics and higher switching speeds. In a memory cell according to an embodiment of the present invention, silver selenide and a chalcogenide glass, such as germanium selenide (Ge<SUB>x</SUB>Se<SUB>(1-x)</SUB>) are combined in an active layer, which supports the formation of conductive pathways in the presence of an electric potential applied between electrodes. Advantageously, embodiments of the present invention can be fabricated with relatively wide ranges for the thicknesses of the silver selenide and glass layers.
Patent AU-2003230201-A1 (AU)
Title: Hydraulic joint articulated device and use thereof with a heat radiator
Inventor: BERGAMANTE RAFFAELE
IPC: F24D19/02
Filed: 2003-04-10
Abstract: A hydraulic joint articulated device (1) effectively supports a radiator allowing a remarkable freedom of motion and has a pair of articulated connectors (2), each comprising: hinge members (5, 6) apt to be assembled and comprising a respective hydraulic channel (7, 8), in which there is obtained a pin seat (9, 10) with a tubular pin (14) having a respective hydraulic channel (21) forming a hydraulic joint extending between the respective connector seats (11, 12); and a valve seat (22) at one end of said tubular pin (14), and a respective shutter member (23) located in an opening (24) obtained in one (5) of said hinge members (5, 6), further comprising, at each articulated connector (2), a tubular duct (29) extending from the respective connector seat (11) to a mouthpiece section (30) apt to receive a waterworks piping (4), extending inside a masonry.
Patent AU-2003230264-A1 (AU)
Title: Plasma assisted dry processing
Inventor: DOUGHERTY MICHAEL L SR
IPC: A62D3/00
Filed: 2003-05-07
Abstract: Methods and apparatus are provided for igniting, modulating, and sustaining a plasma for various plasma processes and treatments. In one embodiment, a plasma is ignited by subjecting a gas in a multi-mode processing cavity to electromagnetic radiation having a frequency between about 1 MHz and about 333 GHz in the presence of a plasma catalyst, which may be passive or active. A passive plasma catalyst may include, for example, any object capable of inducing a plasma by deforming a local electric field. An active plasma catalyst can include any particle or high energy wave packet capable of transferring a sufficient amount of energy to a gaseous atom or molecule to remove at least one electron from the gaseous atom or molecule, in the presence of electromagnetic radiation.
Patent AU-2003232312-A1 (AU)
Title: Apparatus and method for aligning and positioning implants in a body
Inventor: JOHNSTONE ALAN JOHN
IPC: A61B19/00
Filed: 2003-04-28
Abstract: An apparatus for handling of an implant for a body is described. The apparatus includes a head with a radio-translucent first window insert. The apparatus also includes an arm that is telescopically extendible along a first axis. The head is rotatable around the first axis and axially moveable along the first axis. A radio-opaque pattern is on each face of the window insert. The two patterns complement one another to occlude radiation only when the angle of the radiation striking each window is precisely perpendicular to the plane of the window.  An apparatus having a radio-translucent arm with an array of parallel radio-opaque markings is also described. The apparatus comprises an arm and a head, having a clamp for a drill guide/K-wire. The clamp, the arm and the array of radio-opaque markings are mutually parallel. The clamp defines an axis of insertion for the drill guide/K-wire, the axis being spaced from the plane of the array.
Patent AU-2003243846-A1 (AU)
Title: Viral inhibitors
Inventor: NEYTS JOHAN
IPC: C07D471/04
Filed: 2003-07-03
Abstract: This invention relates to a class of imidazo[4,5-c]pyridine compounds which are useful for the treatment or prevention of a viral infection, and for inhibiting the replication of a virus of the family of the Flaviviridae or the Picornaviridae such as BVDV, HCV or Cocxsackie virus.  This invention relates to a process for preparing this class of imidazo[4,5-c]pyridine compounds.
Patent AU-2003262519-A1 (AU)
Title: Two-component packaging unit
Inventor: OSWALD KLAUS
IPC: B65D51/28
Filed: 2003-09-22
Abstract: The invention relates to a packaging unit for two substances to be mixed, which are to be stored separately before utilization, more particularly a fluid and a powder substance. The invention comprises a first container (1) and a second container (4) that can me moved in the neck of the first container. The second container is moved and thereby opened by screwing on the closing cap (5) of the first container.