Patent TW-201742867-A (TW)
Title: Novel 5H-Pyrrolo[2,3-d]Pyrimidin-6(7H)-one derivative useful as a prophylactic and/or therapeutic agent for diseases associated with the various kinases, particularly cancer
Inventor: SUGIMOTO TETSUYA
IPC: C07D487/04
Filed: 2017-05-19
Abstract: The present invention provides a novel compound exhibiting an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase and/or a cell proliferation inhibiting effect. Furthermore, based on the inhibitory activity, the present invention provides a medicine useful for prophylaxis and/or treatment of diseases associated with at least one kinase selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase, particularly cancer. The compound of the present invention or a salt thereof is represented by formula (I), in which R1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group having 1 to 3 heteroatoms selected from N, S and O and being able to have a substituent; R2 represents a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; R3, R4 and R5 may be the same or different and represent a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group, or R3 and R4 together with a nitrogen atom to which they are attached form a 4- to 6-membered monocyclic saturated heterocyclic group having 1 to 3 heteroatoms selected from N, S and O and each R5 may be the same or different and is a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group, or R4 and R5 together with a nitrogen atom to which they are attached and the adjacent carbon atoms form a 4- to 6-membered monocyclic saturated heterocyclic group having 1 to 3 heteroatoms selected from N, S and O and each R3 may be the same or different and represents a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; R6 represents a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; R7 and R8 may be the same or different and represent a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group, or R7 and R8 together with a carbon atom to which they are attached form a C3-C10 cycloalkyl group; X1 and X2 may be the same or different and represent N or CR9, wherein R9 represents a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; and X3 represents N or CH when the broken line (---) represents a single bond, and represents C when the broken line represents a double bond, wherein X2 represents N when X1 represents CR9.