baber/WOPTO huggingface dataset:
Patent DK-2307458-T3 (DK)
Inventor: URECH DAVID
IPC: C07K16/46
Filed: 2009-06-25
Granted: 2018-07-16
Abstract: The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
Patent DK-2267023-T3 (DK)
Inventor: TAHARA HIDEAKI
IPC: C12N5/00
Filed: 2003-09-12
Granted: 2015-02-23
Abstract: The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO: 2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO: 29, 30, 33, 34, 40, or 46; and peptides with cytotoxic T cell inducibility, in which one, two, or several amino acids are substituted or added to the above-mentioned amino acid sequences, as well as pharmaceuticals for treating or preventing tumors, where the pharmaceuticals comprise these peptides. The peptides of this invention can be used as vaccines.
Patent DK-2283868-T3 (DK)
Inventor: THORPE PHILIP E
IPC: A61P35/00
Filed: 2003-07-15
Granted: 2016-04-25
Abstract: Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
Patent DK-2661305-T3 (DK)
Inventor: MERHI WILLIAM M
IPC: A61M29/00
Filed: 2011-12-27
Granted: 2018-09-03
Abstract: Embolic protection devices and methods for capturing embolic debris. An embolic protection device includes a pigtail catheter having a lumen for housing a guidewire. The distal portion of the catheter has one or more apertures in fluid communication with the lumen and one or more radiopaque markers on the distal-most section. The device includes a self-expanding filter coupled to a side of the catheter and a movable outer sheath surrounding the catheter. The outer sheath holds the filter in a collapsed configuration when surrounding the filter. The outer sheath is proximally retracted to deploy the filter. A method of capturing embolic debris includes inserting a guidewire into a body lumen, tracking the device over the guidewire, retracting the guidewire, positioning the device using the radiopaque marker, retracting the outer sheath and deploying the filter, performing a procedure, and advancing the outer sheath to recapture the filter.
Patent DK-2913059-T3 (DK)
Inventor: TAMAI KATSUTO
IPC: C07K14/52
Filed: 2013-10-24
Granted: 2018-06-25
Abstract: Fragment peptides having a proper length, which consists of a portion of the HMGB1 protein were synthesized, and the peptides were confirmed to show therapeutic effects on injury of the spinal cord.
Patent DK-0480981-T3 (DK)
Inventor: BRANCQ BERNARD
IPC: A61K39/39
Filed: 1990-06-29
Granted: 1993-11-29
Abstract: PCT No. PCT/FR90/00484 Sec. 371 Date Feb. 28, 1992 Sec. 102(e) Date Feb. 28, 1992 PCT Filed Jun. 29, 1990 PCT Pub. No. WO91/00106 PCT Pub. Date Jan. 10, 1991.The present invention relates to injectable multi-phase solutions of W/O/W type, usable as vaccines or as vehicles of active substances in human and veterinary medicine, which are pharmaceutically acceptable in each one of their constituents, stable for at least 12 months in storage at 4 DEG  C., of viscosity less than 300 mPas and comprise at least the following constituents: an oily adjuvant composed of: a water-immiscible oily phase representing between 20 and 70% of the formula, an emulsifying system selected so that the inversion point of the resulting emulsion ranges between 25 DEG  and 45 DEG  and represents between 2 and 10% of the formula, an aqueous phase containing the antigens or the active substances and representing between 20 and 78% of the formula and obtained in a single mixing operation.
Patent DK-0510003-T3 (DK)
Inventor: ALKER DAVID
IPC: C07D401/12
Filed: 1990-11-28
Granted: 1996-01-29
Abstract: PCT No. PCT/EP90/02039 Sec. 371 Date Jul. 2, 1992 Sec. 102(e) Date Jul. 2, 1992 PCT Filed Nov. 28, 1990 PCT Pub. No. WO91/10650 PCT Pub. Date Jul. 25, 1991.According to the invention there is provided a compound of formula (I): R1-O(CH2)mA(CH2)nXR or a pharmaceutically acceptable salt thereof, wherein R1 is a group of formula (a or b) where Z is -(CH2)2-, -CH=CH-, -CH2-S- or -CH2-O-; R is a group of formula (c, d or Het) and A is a group of formula (e, f or g) in which the N atom is attached to the group (CH2)n; m is 1 or 2; n is an integer of from 1 to 4; p is 1, 2 or 3; R2 and R3 are each independently hydrogen, C1-C4 alkyl, hydroxy-(C1-C4 alkyl), hydroxy, C1-C4 alkoxy, halo, trifluoromethyl, nitro, cyano, sulphamoyl, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), carboxy, -CO2(C1-C4 alkyl), -CH2)qCONR4R5, - (CH2)qOCONR4R5, -CH2)qNR6R7 or -NHSO2NH2 in which R4 and R5 are each independently H or C1-C4 alkyl, q is 0, 1 or 2, and either R6 and R7 are each independently H or C1-C4 alkyl or R6 is hydrogen and R7 is -SO2(C1-C4 alkyl), -CO(C1-C4 alkyl) or -CONH(C1-C4 alkyl); X is a direct link, O or S; Y and Y1 are each independently O or CH2; and Het is pyridyl, pyrazinyl or thienyl. The compounds are useful as muscarinic receptor antagonists, particularly in the treatment of irritable bowel syndrome.
Patent DK-0474080-T3 (DK)
Inventor: BEUTLROCK ERWIN
IPC: A01K1/02
Filed: 1991-08-25
Granted: 1993-11-29
Abstract: A locking unit (12, 70) allows an automatic shutting-in and letting-out operation for a group of pigs. At a particular moment, only one pen (1, 51) is ever opened, whilst all the others remain closed. Only one animal at a time is therefore let out. When this animal finds the open pen (1, 51), a release lever (36, 64) is actuated and closes this pen (1, 51), and at the same time the locking unit (12, 70) is preset via a blocking member (20, 69) and spacer rods (21, 86) for the opening of any other pen (1, 51) so that one of the animals can open its pen (1, 51) automatically. This prevents the animals from having a disturbing influence on one another. A shut-off device (80) and an access device (10) make it possible to intervene on the exit side or on the entry side in the automatic shutting-in and letting-out operation, so as to keep individual pens (1, 51) closed or to open them, whilst the automatic operation can be continued unchanged for all the other animals. <IMAGE>
Patent DK-0505445-T3 (DK)
Inventor: OTT GUENTHER DR
IPC: C08G59/22
Filed: 1990-12-17
Granted: 1995-04-18
Abstract: PCT No. PCT/EP90/02211 Sec. 371 Date Jul. 28, 1992 Sec. 102(e) Date Jul. 28, 1992 PCT Filed Dec. 17, 1990 PCT Pub. No. WO91/09917 PCT Pub. Date Jul. 11, 1991.In order to increase the stone chip resistance of automobile finishes aqueous electrocoating paints are used which are produced by the use of a pigment paste which contains as grinding resin an at least partially protonated epoxide-amine adduct which is obtainable by reacting (A) a glycidyl ether of a polyphenol which contains on statistical average at least one epoxide group in the molecule, or a mixture of such glycidyl ethers, (B) a polyglycidyl ether of a polyol which contains on statistical average more than 1.0 epoxide groups in the molecule, or a mixture of such polyglycidyl ethers, and (C) a compound which contains a primary amino group in the molecule or a mixture of such compounds with each other in such a stoichiometric ratio that an epoxide-amine adduct is obtained in which on statistical average at least 2.0 primary amino groups of the component (C) are incorporated in a chain-extending function with the formation of tertiary amino groups and the resultant epoxide-amine addict is at least partially protonated.
Patent DK-0546421-T3 (DK)
Inventor: SCHLAK OTTFRIED DR
IPC: C09D7/80
Filed: 1992-11-30
Granted: 1995-06-06
Abstract: Prepn. comprises (a) dispersing the inorganic components in the presence of small amts. of pigment-wetting agents in at least 80% of the total water used; (b) dispersing silicone in (a) without emulsifiers; and (c) adding an aq. dispersion of an organic polymer. Pref emulsifier-free paints and plasters (I) contain 5-50 wt.% of silicone.
Patent DK-0567503-T3 (DK)
Inventor: MELLORS ALAN
IPC: C12N5/06
Filed: 1992-01-15
Granted: 1998-08-24
Abstract: PCT No. PCT/CA92/00019 Sec. 371 Date Aug. 12, 1993 Sec. 102(e) Date Aug. 12, 1993 PCT Filed Jan. 15, 1992 PCT Pub. No. WO92/13078 PCT Pub. Date Aug. 6, 1992A purified DNA molecule encoding a glycoprotease from Pasteurella haemolytica is disclosed. The DNA comprises a sequence of approximately 975 base pairs coding for a glycoprotease having a molecular weight of approximately 35.2 kD. The glycoprotease is specific for cleaving O-glycosylated carbohydrate portions from O-glycoproteins. The glycoprotease has a major cleavage site in glycophorin A between Arg31 and Asp32.
Patent DK-0636025-T3 (DK)
Inventor: BENDER PAUL ELLIOT
IPC: C07C255/54
Filed: 1993-03-12
Granted: 2001-10-29
Abstract: Novel cyclohexanes of Formulas (I) and (II)     <IMAGE>  (I)    <IMAGE>  (II)  are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.
Patent DK-0634934-T3 (DK)
Inventor: GOLD PHIL
IPC: A23L1/305
Filed: 1993-03-22
Granted: 2000-06-13
Abstract: Undenatured whey protein concentrate is administered to HIV-seropositive individuals to elevate their blood mononuclear cells, glutathione (GSH) level, body weight and sense of well being. In addition T-helper cells concentration and their T-helper cells/T-suppressor cells ratio are slightly elevated.
Patent DK-0637460-T3 (DK)
Inventor: BAIL GUENTHER DR
IPC: A63B55/60
Filed: 1994-02-17
Granted: 1999-02-15
Abstract: PCT No. PCT/DE94/00872 Sec. 371 Date Jan. 23, 1996 Sec. 102(e) Date Jan. 23, 1996 PCT Filed Jul. 27, 1994 PCT Pub. No. WO95/03858 PCT Pub. Date Feb. 9, 1995An automotive golf caddy has a high frequency position finder and an ultrasonic position finder. When the caddy is placed in readiness by means of a manual transmitter, it first determines whether it receives ultrasonic signals from the manual transmitter. If that is not the case, it determines by high frequency position finding the direction of the manual transmitter and approaches the transmitter on a straight path at a relatively high speed. When the caddy enters the ultrasonic position finding range, it is automatically switched to ultrasonic position finding, follows the manual transmitter even in curves and continuously determines its distance from the transmitter. When a predetermined minimum distance is reached, the motors of the caddy are switched off. It will only follow the transmitter automatically once again when the transmitter reaches a predetermined distance from the caddy. The ultrasonic position finding allows the caddy to be accurately kept at a predetermined minimum distance from the player.
Patent DK-0669394-T3 (DK)
Inventor: STEFFENS GERD JOSEF PROF DR
IPC: C12N9/72
Filed: 1994-06-09
Granted: 2000-05-29
Abstract: Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.
Patent DK-0607054-T3 (DK)
Inventor: HONJO TASUKU
IPC: C07K16/00
Filed: 1994-01-14
Granted: 2003-03-17
Abstract: A process for constructing a cDNA library which has a selectivity for signal peptides, that makes it possible to efficiently identify unknown and useful polypeptide comprising a signal peptide. A novel polypeptide consisting of 89 amino acids (including a signal peptide) produced by a stroma cell line, which is useful as an agent for preventing or treating, for example, anemia, leukopenia or infections and the like, and DNAs coding for said polypeptide, have been identified using the process of the invention.
Patent DK-0668373-T3 (DK)
Inventor: BARTHOLOMEW JOHN J
IPC: C23F13/02
Filed: 1994-02-21
Granted: 2000-03-06
Abstract: Cathode protection of a reinforced concrete structure (41) utilizes a metal anode (14) such as a zinc anode in combination with a pressure sensitive ionically conductive hydrogel (24) in contact with at least a portion of the surface of the anode. Preferably, the anode and ionically conductive hydrogel are flexible and supplied in roll form. The combination may further include the addition of salt to the hydrogel as well as application to the metal-hydrogel combination of Type III cement. The cathodic protection may be carried out with or without a power source. <IMAGE>
Patent DK-0709104-T3 (DK)
Inventor: HADVARY PAUL
IPC: A61M5/178
Filed: 1995-10-20
Granted: 1998-09-28
Abstract: An injection device consists of a housing with a contact surface which is applied to the skin of a patient, a tube for penetrating the skin and applying a liq., and a protective element. The tube is firmly fixed relative to the housing, and is surrounded by a protective element. The latter can be moved axially between a primary end position and a secondary end position. The protective element extends over the tube in the primary position, while in the secondary position it is withdrawn into the housing. A drive moves the protective element.
Patent DK-0684234-T3 (DK)
Inventor: AUDIA JAMES EDMUND
IPC: C07D221/10
Filed: 1995-05-23
Granted: 2000-09-18
Abstract: A process for preparing 10b-methyl-3-oxo-benzo[f] quinolines of the formula <CHEM> wherein R is hydrogen, methylthio, chloro, bromo or fluoro, and is located at the 7-, 8- or 9-position; comprising reacting a compound of the formula <CHEM> with methyl iodide in an ether solvent to prepare a compound of the formula <CHEM> combining acrylic anhydride or acryloyl chloride with the reaction mixture comprising the compound of formula III to prepare a compound of the formula <CHEM> quenching the reaction with sodium bicarbonate, evaporating the organic solution comprising the compound of formula IV; and combining the residue comprising the compound of formula IV with a trialkylsilane and trifluoroacetic acid in the absence of a solvent to prepare the compound of formula I.
Patent DK-0741870-T3 (DK)
Inventor: WHITE MARK LESLIE
IPC: G01N33/68
Filed: 1995-01-24
Granted: 1999-12-13
Abstract: The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.
Patent DK-0804098-T3 (DK)
Inventor: FAELTH LARS
IPC: A24D3/04
Filed: 1995-09-07
Granted: 2000-12-18
Abstract: A tobacco smoke filter contains at least one hydrophobic zeolite, and then preferably a zeolite of the faujasite types designated as ST 100, ST 101, ST 102, ST 103 and ST 104, and optionally in combination with other filter material or materials.
Patent DK-0769296-T3 (DK)
Inventor: SCHWAB WILFRIED DR
IPC: A61K31/44
Filed: 1996-10-14
Granted: 2001-10-22
Abstract: The use of isoxazole and crotonic acid compounds of formula (I) and (II) and their salts is claimed for the treatment of cancer. R1 = 3-5C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl; R2 = CF3, OCF3, SCF3, OH, NO2, halo, benzyl, phenyl, or CN; or O-phenyl (which is optionally substituted by one or more 1-4C alkyl, halo, OCF3 or OCH3 groups); R<3> = 1-4C alkyl, halo or H; X = CH or N.
Patent DK-0879442-T3 (DK)
Inventor: ROSTEDT JAN
IPC: H05B47/10
Filed: 1996-03-05
Granted: 2002-01-21
Abstract: The invention relates to a method for controlling a switch and in this method, the changing of prevailing light intensity is observed and the switch is controlled on the basis of the prevailing light intensity so that the switch is switched on when the light intensity falls below the set threshold value and then a load, for example an illuminator, is connected to a source of electricity and respectively, the switch is switched off when the light intensity exceeds the set threshold value and then the load is disconnected from the source of electricity. According to the invention, when a prominent and relatively stable change in the prevailing light intensity (A) is detected, this is interpreted as being morning and/or evening depending on the direction of the change; from these moments of changes in light intensities, the time of sunrise (ta) and/or respectively the time of sunset (tb) may be calculated; and according to the calculated time of sunrise and/or sunset, a clock is synchronized and by means of this clock, the daily timing of the switch is achieved as well as the control of the switching of the load, such as an illumintaor, connected via the switch to the source of electricity and off from it by following a desired program.
Patent DK-0820744-T3 (DK)
Inventor: JOHNSON BRUCE C
IPC: A61F5/08
Filed: 1992-06-02
Granted: 2004-08-16
Abstract: A nasal dilator 10 that prevents the outer wall tissue 60, 62 of the nasal passages 54, 56 of the nose 12 from drawing in during breathing comprises a truss member 16. The truss member 16 includes flexible strip of material 18 having a first end region 20, a second end region 22 and an intermediate segment 24. The first and second end regions 20, 22 are adapted to engage the outer wall tissue 60, 62 of first and second nasal passages 54, 56 of the nose 12. The truss member 16 further includes resilient bands 30a, 30b secured to the strip of material 18. The resiliency of the bands 30a, 30b acts to stabilise the outer wall tissue 60, 62 and thereby prevents the outer wall tissue 60, 62 of the nasal passages 54, 56 from drawing in during breathing. The first and second end regions 20, 22 are secured to the outer wall tissue 60, 62 by an adhesive layer whose effect is less at the intermediate segment 24.
Patent DK-0935684-T3 (DK)
Inventor: PLEMMONS HAROLD F
IPC: A41D19/00
Filed: 1997-10-20
Granted: 2004-05-10
Abstract: A knitted glove including a thumb and a body, a crotch defined between the thumb and the body, and a thickened knitted portion along at least a portion of the crotch. The present invention is further directed to a method and apparatus for forming such a knitted glove.
Patent DK-0907835-T3 (DK)
Inventor: DENHAM KEITH
IPC: B21J15/32
Filed: 1997-07-02
Granted: 2004-10-11
Abstract: A self-piercing rivet comprising a rivet slug incorporating a bore with a tapered outer end at the end of the rivet intended to penetrate a workpiece, said tapered end forming a piercing region adapted to ease penetration of the rivet into workpieces and wherein the other end of the rivet slug also incorporates a bore with a tapered outer end, thus obviating the need to orientate the rivet with respect to the workpiece prior to deformation. <IMAGE>
Patent DK-0867946-T3 (DK)
Inventor: WAMBACH KARSTEN DR
IPC: H02S40/34
Filed: 1998-03-26
Granted: 2009-02-09
Abstract: In a panel-like photovoltaic solar module, used especially as a facade or roof element and having outer connection leads for electrical connection to further solar modules, the connection leads (25) are fixed to a connection tab (12) which is connected to a module connection element (10) extending outside the panel structure and which is arranged in a tangential plane of the module connection element (10), the latter being connectable to corresponding module connection elements of adjacent solar modules. The interior cover (24) of the module, which is spaced from an exterior pane (20) to define an interspace (22) for holding solar cells, may be in the form of a foil sandwich with one or more fluoropolymer-backed base foils of plastic (e.g. polyester) or metal (e.g. aluminium).
Patent DK-0869181-T3 (DK)
Inventor: DOMENIGHINI MARIO
IPC: C12N15/31
Filed: 1992-12-30
Granted: 2005-01-31
Abstract: An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-104 or Pro-106 are replaced with another amino acid or deleted. Examples of specific replacements include Val-53-Asp, Val-53-Glu, Val-53-Tyr, Ser-63-Lys, Val-97-Lys, Val-97-Tyr, Tyr-104-Lys, Tyr-104-Asp, Tyr-104-Ser, Pro-106-Ser. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis. <IMAGE>
Patent DK-1029852-T3 (DK)
Inventor: TORRENS-JOVER ANTONI
IPC: C07D231/12
Filed: 1998-07-31
Granted: 2003-02-24
Abstract: The process comprises (a) the enantioselective reduction of a pro-chiral ketone (III) by the use of a reducer and a chiral catalyst which have been derived from boron in a solvent or a mixture of anhydrous solvents in order to form an enantiomer of an alcohol (II), and (b) the alkylation of (II), in conditions of phase transfer, optionally after isolation and purification of the same, with 2-chloro-N, N-dimethylethylamine in order to form an enantiomer of (I). Cis-olirtine has analgesic properties.
Patent DK-0965436-T3 (DK)
Inventor: KNEUBUEHLER KURT
IPC: B29C51/30
Filed: 1999-05-31
Granted: 2002-09-23
Abstract: The matrix is formed by one or more stacked, dimensionally stable plates (10), especially made of plastic, in which cavities are located, formed by cutout penetrations (11, 12). Independent claims are included for filler bodies, and for the corresponding deep drawing process, in which the complementary filler bodies (33, 34) are placed on locations where deep drawing will occur. They are suited in size and shape, to sink into deep-drawing depressions during their production. Preferred features: The matrix comprises one or more acrylic plates. These have vent grooves facing the base, connecting to vent channels (16). Lower plates in a stack have recesses and/or interconnecting holes to vent grooves of upper plates. Plate thicknesses corresponds with deep drawing steps. In the method, the filler bodies may be adhered or fixed to the sheet, excluding air. They may include penetrations, to make cutouts. They are plastic, optionally injection-molded. Their contours are relieved by twice the sheet thickness or more, from the cavity contours.
Patent DK-0959186-T3 (DK)
Inventor: LEBLOND JEAN-MARIE
IPC: E03D5/10
Filed: 1999-05-11
Granted: 2004-01-12
Abstract: The flushing system comprises a cistern (12) to hold the water for flushing the toilet, fed through a valve and designed to be refilled when the water level drops below a given point. The valve is actuated by a float (30) and a thrust arm (26) which connects the float via a transmission mechanism (16) to a valve opening mechanism (61). When the water reaches a set upper level the inlet valve is closed and the outlet valve (28) opened, flushing the toilet, and once the water drops to a certain level the outlet valve is closed and the inlet valve opened again to refill the cistern.