baber/WOPTO huggingface dataset:
Patent EA-000396-B1 (EA)
Title: Use of imidazol[1.2-a]pyridine-3-acetamide derivatives for the therapeutic treatment of neuropsychiatric syndromes, associated with disfunction of the neutral circuits of the basal ganglia
Inventor: BENINCASA ELENA
IPC: A61K31/44
Filed: 1996-04-02
Abstract: 1. Use of imidazo[1,2-a]pyridine-3-acetamide derivatives of the general formula (I)   wherein Y represents a hydrogen or halogen atom or a C1-C4 alkyl group, A represents a naphthyl radical or a radical,   wherein each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-C4 alkoxy group, a C1-C6 alkyl group or CF3, CH3S-, CH3 SO2- or -NO2, and each of R1 and R2 independently of one another represents either a hydrogen atom, or a straight or branched C1-c5 alkyL group which is unsubstituted or substituted by one or more halogen atoms, hydroxyl, -N(C1-C4 alkyl, carbamoyl or C1-C4 alkoxy groups, or an allyl group, or a propargyl group, or a C3-C6 cycloalkyl group, or a benzyl group, or a phenyl group, not both R1 and R2 being hydrogen, or -NR1R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula   wherein X is O, S, CHOR' or N-R, R' being hydrogen or benzyl and R being hydrogen, a C1-C4 alkyl group, or phenyl which is unsubstituted or substituted by -methoxy group or a halogen atom provided that, if Y is 6-chloro, A is not 4-chlorophenyl,  to produce a drug for the treatment of neuropsychiatric syndromes, associated with disfunction of nervous chains of basal ganglions. 2. The use of Claim 1, wherein said compounds of the general formula (A) are used to produce a drug for the treatment of Parkinson's disease, parkinsonian syndromes, other extrapyramidal syndromes such as those classified under the heading of "parkinsonism plus" (Steele-Richardson-Olszewski syndrome, cortical-basal ganglionic degeneration, multi-system atrophy, Wilson's disease, Hallervorden-Spatz disease, Huntington's disease, neuroacanthocytosis), obsessive-compulsive disorder and other obsessive-compulsive syndromes, frontal and subcortical dementias. 3. The use of Claim 1, wherein the imidazo[1,2-a]pyridine-3-acetamide derivative has the following formula (II)   wherein R1 is halogen, preferably chlorine, or a C1-C4 alkyl group; Y is halogen, preferably chlorine, or a C1-C4 alkyl group; and R1 and R2, equal or different, are hydrogen or a C1-C4 alkyl group, provided that, if Y is 6-chloro, R3 is not h-chloro. 4. The use of Claim 3, wherein the imidazo[1,2-a]pyridine-3-acetamide is zolpidem [N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide hemitartrate].
Patent EA-006623-B1 (EA)
Title: Method and apparatus for melting metals
Inventor: MORROW MARVIN S
IPC: F27B14/06
Filed: 2002-11-11
Abstract: A method and apparatus for melting metals uses microwave energy as the primary source of heat. The metal or mixture of metals is placed in a ceramic crucible (10) which couples, at least partially, with the microwaves to be used. The crucible is encased in a ceramic casket (14) for insulation and placed within a microwave chamber (1). The chamber (1) may be evacuated and refilled to exclude oxygen. After melting of the metal, the crucible (10) may be removed for pouring, or the metal may be poured within the chamber (1) by dripping or running into a heated mold within the chamber. Apparent coupling of the microwaves with softened or molten metal produces high temperatures with great energy savings.
Patent EA-007474-B1 (EA)
Title: Induction method for cell differentiation
Inventor: NEBOLSIN VLADIMIR EVGENIEVICH
IPC: A61K31/16
Filed: 2003-02-28
Abstract: The invention relates to the induction method for cell differentiation which consists in injecting peptide derivatives having the following general formula (I):said peptide derivatives are used for treating oncological diseases, in particular for stabilising melanoma growth, increasing the efficiency of melanoma immunotherapy and reducing haematological toxicity of chemotherapy.
Patent EA-006965-B1 (EA)
Title: Encoded self-assembling chemical libraries
Inventor: NERI DARIO
IPC: G01N33/58
Filed: 2002-04-15
Abstract: The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1') of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m') of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.
Patent EA-010963-B1 (EA)
Title: Method and system for cooling a natural gas stream and separating the cooled stream into various fractions
Inventor: BETTING MARCO
IPC: B01D53/24
Filed: 2006-02-24
Abstract: A method for cooling a natural gas stream (CH) and separating the cooled gas stream into various fractions having different boiling points, such as methane, ethane, propane, butane and condensates, comprises: cooling the gas stream (1,2); and separating the cooled gas stream in an inlet separation tank (4); a fractionating column (7) in which a methane lean rich fluid fraction (CH) is separated from a methane lean fluid fraction (C+H); feeding at least part of the methane enriched fluid fraction from the inlet separation tank (4) into a cyclonic expansion and separation device (8), which preferably has an isentropic efficiency of expansion of at least 80%, such as a supersonic or transonic cyclone; and feeding the methane depleted fluid fraction from the cyclonic expansion and separation device (8) into the fractionating column (7) for further separation.
Patent EA-012677-B1 (EA)
Title: Gear machine for combining two fluid streams and associated method
Inventor: ALLARD PHILIP
IPC: F04C11/00
Filed: 2006-05-17
Abstract: Methods, devices, and systems are disclosed for combining fluids of different pressures and flow rates in, for example, gas gathering systems, gas wells, and other areas in which independently powered compressors are not desired. Methods, devices, and systems for turning a shaft are also provided, as are methods, devices, and systems for dropping pressure in a gas line.
Patent EA-012127-B1 (EA)
Title: Article of the ballistic protection
Inventor: JACOBS MARTINUS JOHANNES NICOLAAS
IPC: F41H5/04
Filed: 2006-06-29
Abstract: The invention relates to a preformed sheet comprising at least two mono-layers, each mono-layer containing a fibrous network with fibres having a tensile strength of at least about 1,2 GPa and a tensile modulus of at least 40 GPa and a binder; and a separating film on at least one of the outer surfaces of the sheet, characterized in that the separating film has an areal density of between 1 and 5 g/m. Owing to this preformed sheet assemblies and articles, a substantially higher ballistic protection level at a certain weight can be obtained. The invention further relates to an assembly of at least two such sheets and to a flexible article of the ballistic protection comprising said assembly.
Patent EA-014495-B1 (EA)
Title: Pyrimidine compounds as serotonin receptor modulator
Inventor: DVORAK CURT A
IPC: A61K31/505
Filed: 2006-07-27
Abstract: Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases.
Patent EA-014340-B1 (EA)
Title: Braking device for elevating platform assembly
Inventor: NOEL GERARD
IPC: B66F11/04
Filed: 2007-05-17
Abstract: A braking device for an elevated platform assembly comprising a platform moveable along a generally vertical mast supporting an upright rack comprises an input gear assembly in mating engagement with the rack, a centrifugal actuator communicating with the input assembly and a spring-loaded brake responsive to the centrifugal actuator. The spring-loaded brake engages the rack and arrests the platform when the platform descends the mast at a rate above an upper threshold limit.
Patent EA-026840-B1 (EA)
Title: Phased array antenna and a method of operating a phased array antenna
Inventor: MAYO RICHARD
IPC: H04B7/08
Filed: 2009-07-17
Abstract: The application describes an element of a phased array antenna. The element comprises a phase tracking circuit configured to multiply the in-phase component (I) of a local output signal by the quadrature phase component (Q) of an external output signal to generate a phase control signal (535) and/or to multiply the quadrature component (Q) of a local output signal by the in-phase component (I) of an external output signal to generate a phase control signal (535).
Patent EA-022180-B1 (EA)
Title: Shaft furnace charging device equipped with a cooling system and annular swivel joint therefore
Inventor: THILLEN GUY
IPC: F27B1/24
Filed: 2010-08-26
Abstract: Annular swivel joint (300), especially for use in a shaft furnace charging device (10) that is equipped with a cooling system (12) with a stationary and a rotary circuit portion (30, 32). The annular swivel joint (300) comprises an annular fixed part (312) and an annular rotary part (310) and include an annular trough that defines an annular volume, via which the circuits portions (30, 32) communicate. The annular swivel joint (300) is characterized by: a stationary forward connection (302) for receiving cooling fluid from the stationary circuit portion (32); a rotary forward connection (304) for supplying cooling fluid to the rotary circuit portion (30); a rotary return connection (306) for receiving cooling fluid from the rotary circuit portion (30); and a stationary return connection (308) for returning cooling fluid to the stationary circuit portion (32); a partition (320) dividing the annular volume into an annular external cavity (322) and an annular internal cavity (324) so that the forward connections (302, 304) are coupled via one of the external and internal cavities (322/324) and the return connections (306, 308) are coupled via the other cavity (324/322), so that the internal cavity (324) is at least partially surrounded by the external cavity (322). The cavities (322, 324) are in double leakage-permitting communication between the external and internal cavities through annular first and second clearances (350, 352) provided to allow relative rotation between the fixed and rotary parts (310, 312); and annular flow restrictors (360, 362) provided in the first and second clearances (350, 352) respectively to reduce leakage between the cavities (322, 324).
Patent EA-026098-B1 (EA)
Title: Process of recovering sucrose and betaine from syrup
Inventor: AIRAKSINEN JYRKI
IPC: C07C229/12
Filed: 2011-03-29
Abstract: The invention relates to a multi-profile chromatographic sequential SMB process of separating and recovering betaine and sucrose from concentrated raw juice or thick juice. In the process of the invention, the betaine subprofile and the residual subprofile of successive separation profiles are overlapping. A sucrose fraction and a betaine fraction containing also residual components are recovered. Betaine is further separated from the betaine fraction for example by chromatographic processes.
Patent EA-022937-B1 (EA)
Title: Three-phase inverter provided with link of increased frequency and voltage
Inventor: TEN VICTOR VILGELMOVICH
IPC: H02M7/5387
Filed: 2012-12-12
Abstract: The invention is aimed at providing a three-phase inverter with a link of increased frequency and voltage and with a simplified transistor control system. The technical result of the invention provides the increase of frequency and voltage, the inventer reliability in elimination of through current passing, lesser materials output by simplification of transistor control elements. It is characterised in that emitters of three transistor modules are connected to the cathode of the first diode, and the anode of the first diode is connected to the terminal of the transformer secondary winding which is connected to the cathode of the second diode, and the anode of the second diode is connected to three collectors of the transistor modules, the three-phase load is connected to three midpoints of the transistor modules, and the zero point of the three-phase load is connected to the second terminal of the transformer secondary winding, wherein the transformer modules are controlled by a control driver with phase shifts relative to each other by 120°.
Patent EA-031081-B1 (EA)
Title: Leaf spring compound
Inventor: TIME EYVIND
IPC: A01B61/04
Filed: 2014-10-08
Abstract: A leaf-spring compound (2) used as a release system (1) especially for soil-working implements, the leaf-spring compound (2) including several leaf springs (215, 215') with substantially identical ground plans and an attachment arrangement (21) which comprises a coupling element (211), a stop element (213) and a supporting element (214), the leaf springs (215, 215') being held together by the attachment arrangement (21) at either end portion (2153) of the leaf springs (215, 215'), each of the end portions (2153) of each leaf spring (215, 215') abutting supportingly in the coupling element (211) and being attached to the coupling element (211) with a clamping bolt (212), the stop element (213) and the supporting element (214), the supporting element (214) creating a clearance to an inner leaf spring (215') and being positioned at least partially over a cut-out (2152) in the leaf springs (215, 215').
Patent EA-036904-B1 (EA)
Title: Antibody molecules which bind tnf alpha
Inventor: ADAMS RALPH
IPC: C07K16/24
Filed: 2016-12-14
Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Patent EA-038627-B1 (EA)
Title: CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND USE THEREOF
Inventor: SEBHAT IYASSU K
Filed: 2017-09-25
Abstract: The invention relates to certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I)or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected fromand ring B, n, R1, R2, R2A, R3 and R3A are as defined herein. The compounds of the invention are useful as mGluR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.
Patent EA-039455-B1 (EA)
Title: Amide compounds and use thereof
Inventor: CHUNG CHENG-HO
IPC: C07D413/12
Filed: 2018-01-22
Abstract: Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof:wherein each of variables R1, R2, L and Z is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof or a pharmaceutical composition containing the same.
Patent ES-2172407-B1 (ES)
Title: Procedimiento para conectar un puente de sensores de resistencia variable a un microcontrolador
Inventor: PALLAS ARENY RAMON
IPC: H03M1/14
Filed: 2000-06-21
Granted: 2003-12-16
Abstract: Procedimiento para conectar un puente de sensores de resistencia variable a un microcontrolador. Procedimiento para conectar directamente un puente de sensores de resistencia variable a un microcontrolador, caracterizado porque no emplea ningún circuito integrado ni componente electrónico activo entre el puente de sensores y el microcontrolador. El procedimiento de conexión se basa en conectar sucesivamente cada uno de tres terminales del puente al mismo nivel de tensión y el otro terminal del puente se conecta a un condensador eléctrico (o una inductancia eléctrica) cuyo nivel de tensión se detecta a través de otro terminal del microcontrolador.
Patent ES-2207357-B1 (ES)
Title: Instalacion para el reciclaje de subproductos agroalimentarios.
Inventor: FERRER FERRER CARLOS MANUEL
IPC: A23K10/37
Filed: 2001-07-06
Granted: 2005-03-01
Abstract: Instalación para el reciclaje de subproductos agroalimentarios que comprende una tolva (1) en forma de bandeja con pendiente situada debajo de las mesas de tria, pasando los frutos dañados o podridos por una gruesa tubería, a un triturador (2) provisto de una bomba (3), que impulsa el jugo obtenido por una tubería (4) a un depósito central (5) en el interior de la instalación, con el suministro a través de otros tubos (6), bombeándose el producto a un depósito exterior (7) en forma de silo elevado sustentado por una estructura metálica (8), pudiendo transferir su contenido a camiones cisterna (9), intercomunicando los depósitos entre sí, por los conductos tubulares (10), distribuyéndose el jugo a distintas granjas ganaderas (11) almacenando el producto dentro de un depósito receptor (12) con tuberías de salida (13), (14) y (15) para el producto natural, con más mezcla de agua y con mezcla de piensos respectivamente.
Patent ES-2195792-B1 (ES)
Inventor: AKINFIEV TEODOR
IPC: A63H11/18
Filed: 2002-05-24
Granted: 2005-03-16
Abstract: The invention relates to an actuator which is characterized in that the kinematic connection between the motor and the working element of the robot comprises a mobile link which is pivot fixed to the base of the actuator, a runner which is mounted to the mobile link and which may slide radially along the length thereof and a lever arm which is kinematically connected to the motor and which is hinge-connected to the runner by means of a pin. In this way, the rotation axes of the mobile link, the lever arm and the pin are parallel and said mobile link is kinematically connected to the working element. The distance between the lines that run alongside the rotation axis of the mobile link and the rotation axis of the lever arm may be greater or smaller than the length of the lever arm. <IMAGE>
Patent ES-2235572-B1 (ES)
Title: Envase para la comercializacion de reactivos para tinciones microbiologicas, histologicas y citologicas.
Inventor: NIETO VELASCO JULIO
IPC: G01N1/31
Filed: 2002-10-09
Granted: 2006-02-16
Abstract: Envase para la comercialización de reactivos para tinciones microbiológicas, histológicas y citológicas. El envase incorpora un cuerpo (1) que configura una cubeta formal y dimensionalmente adecuada para ser acoplada a una máquina automática para este tipo de tinciones, cuerpo dotado de una pestaña perimetral (3) a nivel de su embocadura (2), a través de la que recibe por termo- soldadura a una lámina (4) constitutiva de una tapa de cierre estanco. De esta manera el mismo envase utilizado durante la comercialización del reactivo, es utilizable como contenedor del mismo durante la fase de tinción para la posterior analítica de diagnóstico.
Patent ES-2233142-B1 (ES)
Title: Perfeccionamientos introducidos en el objeto de la patente p9902084, por un dispositivo para retener tierras para revegetacion en taludes de gran pendiente y procedimiento para la fabricacion de una malla.
Inventor: CASADO CASADO ANTONIO
IPC: E01F7/04
Filed: 2002-11-04
Granted: 2006-03-01
Abstract: Perfeccionamientos introducidos en el objeto de la patente P9902084, por un dispositivo para retener tierras para revegetación en taludes de gran pendiente y procedimiento para la fabricación de una malla. El dispositivo comprende por lo menos una malla, y unos elementos de fijación, aptos para fijar la malla al talud. La malla presenta una conformación substancialmente tridimensional y está formada a partir de una pluralidad de varillas. El dispositivo puede comprender adicionalmente una capa laminar, que preferentemente dispone de unos orificios. El dispositivo puede comprender asimismo una retícula formada a partir de una pluralidad de tiras, que pueden tener, a su vez, unos orificios.
Patent ES-2214158-B1 (ES)
Title: Aparato uni-persona para topografia de playas.
Inventor: DELGADO FERNANDEZ IRENE
IPC: G01C9/00
Filed: 2004-03-08
Granted: 2005-07-16
Abstract: Aparato uni-persona para realizar topografía de playas. Compuesto de dos unidades fundamentales: una regla (6) y un sistema de dos varas, una más larga horizontal (1) y otra más corta vertical (2), unidas mediante una escuadra en un ángulo de 90 grados (3). Su uso consiste en colocar el aparato base en la dirección del perfil, con la vara vertical sobre la arena orientada hacia el mar. Tras ajustar la vertical y la horizontal con dos niveles (4 y 7) y una escuadra (5), se mide la altura desde la playa al aparato con la regla. Sucesivas mediciones completan el perfil de playa. Las alternativas para realizar perfiles de playa con un individuo son complejas y de elevado coste; la presente invención supone un coste bajísimo y accesible.
Patent ES-2245891-B1 (ES)
Title: "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo".
Inventor: JUAREZ JIMENEZ JUAN CARLOS
IPC: A61K9/08
Filed: 2004-07-09
Granted: 2006-11-16
Abstract: El método comprende la incorporación extemporánea en una solución acuosa de un principio activo farmacéutico, consistiendo dicha solución acuosa en dos soluciones que resultan ser excipientes universales para cualquiera de dichos principios activos sean en solución en una de ellas, en suspensión en la otra o mixta en una mezcla de ambas. Estas soluciones son de utilización en farmacopea hospitalaria y son aceptadas por la mayoría de pacientes.
Patent ES-2267361-B1 (ES)
Title: Procedimiento para obtener nanoparticulas cristalinas de compuestos insolubles. dispositivo para su puesta en marcha industrial.
Inventor: HERRERO FERNANDEZ PILAR
IPC: B01J13/04
Filed: 2004-10-29
Granted: 2008-03-16
Abstract: Procedimiento para obtener nanopartículas cristalinas de compuestos insolubles. Dispositivo para su puesta en marcha industrial. La presente invención se refiere a un procedimiento de formación de nanopartículas cristalinas de compuestos insolubles de tamaño y composición controlables, que pueden ser depositadas en sustratos de interés industrial, y al dispositivo para su puesta en marcha industrial. Esta invención presenta la ventaja, frente a otras descritas hasta el momento, de que las nanopartículas cristalinas se obtienen en un solo paso. El procedimiento se basa en la fragmentación en gotas de tamaños predeterminados de una solución conductora, que se forma a partir de la mezcla de otras dos disoluciones precursoras líquidas que contienen iones con un producto de solubilidad a temperatura ambiente muy bajo (Kps < 10{sup,-2}), utilizando fuerzas electrohidrodinámicas. Estas disoluciones se hacen fluir concéntricamente y de forma separada hasta la base de un cono de Taylor, donde se mezclan turbulentamente mientras viajan hacia el vértice del cono y cristalizan en el proceso en nanopartículas.