baber/WOPTO huggingface dataset:
Patent DE-69504349-D1 (DE)
Inventor: SOLL RICHARD
IPC: A61P9/02
Filed: 1995-05-03
Granted: 1998-10-01
Abstract: This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for treatment of peripheral vascular disease, congestive heart failure, disorders involving excessive smooth muscle contraction of the urinary tract such as incontinence or of the gastrointestinal tract such as irritable bowel syndrome, asthma, and hair loss and to pharmaceutical compositions containing an invention compound. The present invention discloses compounds represented by the formula (I):    <IMAGE>  I  wherein: R1 and R2, independent from each other, are selected from the following: C1-6 perfluoroalkoxy, C1-6 perfluoroalkyl, C1-6 alkyl, C1-6 alkoxy, hydroxyl, C1-6 alkoxycarbonyl, nitro, cyano, halogen, C1-6 alkylsulfonamido, C1-6 perfluoroalkylsulfonamido, amino, C1-6 acylamino, C1-6 perfluoroacylamino, mono or di-C1-12 alkylamino, C1-6 alkylsulfonyl, C6-10 arylsulfonyl, carboxyl, C1-12 mono or di-alkylaminocarbonyl, or hydrogen; a and b together form an -O- linkage, C=O, or a direct bond: R3 and R4, independent from each other, are H or C1-6 alkyl, optionally substituted by fluorine; R5 is amino or C1-12 mono alkylamine; R6 is H, C1-6 perfluoroalkyl, C1-6 alkyl, C6-10 aryl, or mono or bicyclic heteroaryl containing 1-3 heteroatoms selected from N, O, or S.
Patent DE-69506258-D1 (DE)
Inventor: CANDELA MICHEL
IPC: A61F13/40
Filed: 1995-07-13
Granted: 1999-01-07
Abstract: In the field of hygiene, a novel skin swab device consists of a squeezable container, an intermediate portion screwed onto the container and an applicator located on the end of the intermediate portion. The device is characterized in that the container is a squeezable bottle with a filling opening having a threaded neck on which an end piece is permanently fitted by being held tightly on said thread. The end piece includes a tube passing therethrough, said tube having a curve radius of approximately 120 DEG  in relation to the hand grip, a spongy material with a rounded surface being inserted in a recess, extending well beyond the end of the tube. The device is useful for swabbing human or animal skin with disinfecting, sterilizing or dermal treatment products.
Patent DE-69507512-D1 (DE)
Inventor: SHANN PETER
IPC: F42D1/055
Filed: 1995-11-14
Granted: 1999-03-04
Abstract: PCT No. PCT/GB95/02666 Sec. 371 Date May 7, 1997 Sec. 102(e) Date May 7, 1997 PCT Filed Nov. 14, 1995 PCT Pub. No. WO96/16311 PCT Pub. Date May 30, 1996This invention relates to a detonator firing circuit comprising a control unit and a plurality of detonator circuits. The detonator circuits are arranged to simultaneously receive a "fire" signal and the fire signal initiates all the delay arrangements to allow different groups of detonators to detonate at different times in accordance with a predetermined firing program. In the present invention each detonator circuit has a code individual thereto and the control unit can control and transmit information to every detonator circuit, including the delay to be imparted to the detonator circuit. The identification code for each detonator circuit is preferably one of a large number of identification codes so that the likelihood of the two detonator circuits having the same identification code and having the same firing circuit is extremely small.
Patent DE-69518439-D1 (DE)
Inventor: HEATON WILLIAM
IPC: A61K31/215
Filed: 1995-12-21
Granted: 2000-09-21
Abstract: PCT No. PCT/GB95/02997 Sec. 371 Date Jun. 23, 1997 Sec. 102(e) Date Jun. 23, 1997 PCT Filed Dec. 21, 1995 PCT Pub. No. WO96/20169 PCT Pub. Date Jul. 4, 1996A new salt of a prodrug useful in antibody directed enzyme prodrug therapy (ADEPT) is disclosed. A hydrogen iodide salt of the prodrug N-(4-[N,N-bis(2-iodoethyl)amino]phenoxycarbonyl)-L-glutamic acid is prepared which can be obtained in crystalline form. Preparation of the crystalline form of the prodrug enables preparation of the prodrug in highly pure form.
Patent DE-69525735-D1 (DE)
Inventor: BOS GILLES
IPC: B29C43/18
Filed: 1995-10-13
Granted: 2002-04-11
Abstract: PCT No. PCT/FR95/01344 Sec. 371 Date Jun. 11, 1996 Sec. 102(e) Date Jun. 11, 1996 PCT Filed Oct. 13, 1995 PCT Pub. No. WO96/11792 PCT Pub. Date Apr. 25, 1996The invention relates to a method of making an intraocular implant having a flexible lens. The method includes in using a mold having two parts (12) and (16) which are disposed on either side of a plate (20), e.g. made of PMMA, which plate includes a central orifice. The material (32) that is to constitute the lens portion is disposed in the central cavity of the mold. This material may be an acrylic, for example. After unmolding, the plate (20) is machined to make the haptic, and optionally the part (32) is machined to make the lens.
Patent DE-69531960-D1 (DE)
Inventor: RAINES H
IPC: F42B5/24
Filed: 1995-11-30
Granted: 2003-11-20
Abstract: There is provided a decoppering agent that is added to a propellant charge to remove copper from the rifling of the internal bore of a gun barrel. The decoppering agent consists essentially of a lead-free pulverized additive dispersed in a combustible binder. One suitable decoppering agent is pulverized bismuth metal, dispersed in a nitrocellulose binder. The bismuth metal either vaporizes or liquifies when the propellant charge is ignited and either embrittles or dissolves the copper deposits facilitating removal.
Patent DE-69533284-D1 (DE)
Inventor: VOLKMANN ROBERT A
IPC: C07D213/56
Filed: 1995-03-20
Granted: 2004-08-26
Abstract: PCT No. PCT/IB95/00189 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Mar. 20, 1995 PCT Pub. No. WO95/29909 PCT Pub. Date Nov. 9, 1995This invention relates to compounds of formula (IA), (IB), (IC) or (ID), wherein m, X, Z, R2, R3, R4, R5, R6, R14 and the dotted lines are as defined below, their pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of using them to treat Alzheimer's disease, age-associated memory impairment, Parkinson's disease and other central nervous system disorders. The claimed compounds have the ability to enhance the release of neurotransmitters such as acetylcholine, dopamine and serotonin.    <IMAGE>  (IA)
Patent DE-69534180-D1 (DE)
Inventor: ALITALO KARI
IPC: C12N15/12
Filed: 1995-09-22
Granted: 2005-06-02
Abstract: The present application discloses promoter sequences for Tie, an endothelial cell receptor tyrosine kinase and their use in therapy and diagnosis as well as production of proteins in blood and tissues.
Patent DE-69600574-D1 (DE)
Inventor: COHEN MICHAEL
IPC: F41H5/00
Filed: 1996-11-12
Granted: 1998-10-01
Abstract: The invention provides a composite armor material for absorbing and dissipating kinetic energy from high velocity, armor-piercing projectiles, comprising a panel consisting essentially of a single internal layer of high density ceramic pellets having an Al203 content of at least 85% and a specific gravity of at least 2.5, said pellets being directly bound and retained in panel form by a solidified material which is elastic at a temperature below 250 DEG C, the majority of said pellets each having a major axis in the range of about 3-12 mm, and being bound by said solidified material in a plurality of superposed rows, wherein a majority of each of said pellets is in contact with at least 4 adjacent pellets, and the total weight of said panel does not exceed 45 kg/m<2>. <IMAGE>
Patent DE-69602336-D1 (DE)
Inventor: ABUSLEME JULIO A
IPC: C08F2/24
Filed: 1996-10-29
Granted: 1999-06-10
Abstract: Polymerization process of unsaturated pefluoromonomers, fluoro-containing monomers and optionally in the presence of hydrogen containing olefins, for obtaining polymers contaning hydrogen and fluorine, which utilizes a microemulsion comprising the following components:     (a) water; (b) a fluoropolyoxyalkylene having hydrogen-containing end groups and/or hydrogen-containing repeating units; (c) a fluorine-free organic radicalic initiator for the polymerization of fluoro-containing monomers, soluble in component (B); (d) a fluoro-containing surfactant. fl
Patent DE-69602485-D1 (DE)
Inventor: SOLARI ANTONIO
IPC: E05B47/00
Filed: 1996-03-25
Granted: 1999-06-24
Abstract: Electric safety-lock consisting of a motor (3) which by means of movement reduction gears (4,5) drives a worm screw (6) axially mounted on the driven wheel (5). A slider (8) is keyed onto the worm screw (6) on which the mobile lock studs (9) entering the holes (10) in the locking box (1) are fastened. A mobile rack (13) is mounted on the slider (8); the rack (13) may be operated in case of emergency by a gear wheel (14) meshing with a cylinder or sprocket latch (17) and functioning when using a key (15) or knob. An electric circuit provided with sensors (24, 25, 26) provides for remote control (34) of the door lock by means of opening (A) and closing push-buttons (C) The safety-lock may also be equipped with an alarm system. <IMAGE>
Patent DE-69608854-D1 (DE)
Inventor: NUTI MARCO
IPC: F02B33/02
Filed: 1996-05-22
Granted: 2000-07-20
Abstract: A valve arrangement in an internal combustion engine, into which engine the air-fuel mixture is directly injected by relative pumping elements from a pressure chamber towards at least one cylinder provided with a valve aperture with its relative valve located within a valve body provided with at least one communication channel, between the valve and the valve aperture there being positioned an elastic element which when at rest maintains the valve in its closed position, the valve being inserted into said valve body by way of interposed elements, lockable in their selected position, for adjusting both the preload and its travel. <IMAGE>
Patent DE-69611373-D1 (DE)
Inventor: WILLNER ITAMAR
IPC: G01N5/00
Filed: 1996-07-16
Granted: 2001-02-01
Abstract: Binding between two members of a recognition pair, e.g. antigen-antibody is determined by utilizing a probe which includes a piezoelectric crystal with electrodes on two opposite faces of the crystal. The crystal carries one or more metal plates which may be the same or different than the electrodes, the metal plates having immobilized thereon a first member of a recognition pair. Binding of a second member of the recognition pair to the first member, or dissociation between the two members and release of the second member from the probe, causes a change of immobilized mass which results in a change to the probe's resonance frequency. The immobilized members may be immobilized on the surface of the metal plates by means of a linking group, having the following general formula (I): Z-R<1>-Q, wherein Z represents a sulphur-containing moiety which is capable of chemical association with, attachment to or chemisorption onto the metal, R<1 >represents a connecting group, Q is a functional group which is capable of forming a covalent bond with a moiety of said first member of the recognition pair.
Patent DE-69617743-D1 (DE)
Inventor: KAESSI TIMO
IPC: A47J36/02
Filed: 1996-04-19
Granted: 2002-01-17
Abstract: PCT No. PCT/FI96/00214 Sec. 371 Date Oct. 20, 1997 Sec. 102(e) Date Oct. 20, 1997 PCT Filed Apr. 19, 1996 PCT Pub. No. WO96/33031 PCT Pub. Date Oct. 24, 1996A method for joining two or more metal parts (1, 2) together. According to the invention, the joining is carried out by using roll forming techniques by placing the metal parts (1, 2) on top of each other on the form face (7) of a tool (4) which is made to rotate, and by arranging the topmost part (1) in linear roll contact with a forming tool (6) which is also in rotational movement, whereby the malleable deformation of the metal in the slot between the tools integrates the parts together. A mesh or perforated plate (2) of harder metal in particular can be joined to the sheet-like part (1) of a softer metal by using roll forming, by making the metal ingredient of the latter to penetrate the apertures (12) in the former. The invention can be applied in the manufacture of frying pans or other cooking vessels which are provided with induction-heated bottoms by joining, for example, a magnetic steel mesh or perforated plate to the bottom of a vessel made of aluminum, as part of the forming of an aluminum blank into the form of a vessel by using roll forming.
Patent DE-69625953-D1 (DE)
Inventor: YEH YING CHIN
IPC: G06F11/18
Filed: 1996-04-24
Granted: 2003-03-06
Abstract: A multi-channel system (31) which monitors and identifies faults experienced by elements of the system is provided in accordance with the present invention. The multi-channel system comprises a plurality of line replaceable units (30 or 38) and independent control channels (40, 42 and 44) coupled to a global bus (34). The control channels and the line replaceable units are coupled to the global bus such that each computer channel and each line replaceable unit is a transmitter that transmits messages via the global bus. Each channel contains a plurality of lanes (46, 48 and 50) coupled by a private bus (56), wherein each lane comprises a power supply (52), a processor (54) and an interface (60) to the global bus. However, only one lane of each channel, i.e., the command lane, may transmit messages via the global bus. The processor of each lane of each channel generates a channel majority opinion for each transmitter connected to the global bus that indicates whether a majority of the channels have detected a fault in the transmitter. To determine the channel majority opinion, the processor for each lane of the channel must first generate a lane majority opinion of the channel that indicates whether a majority of the lanes of the channel have detected a fault in the transmitter communicating via the global bus. The command lane of each channel then transmits the lane majority opinion of the channel to each of the other channels via the global bus such that each lane of each channel receives the lane majority opinion generated by the command lane of each of the other channels. The processor of each lane of the channel then qualifies the lane majority opinion of each channel to ensure that the fault detected is not due to a fault in the channel whose command lane sent the lane majority opinion. The processor of each lane then generates a final lane majority opinion of each channel indicating whether a majority of the lanes of the channel have continued to detect the fault in the transmitter after the lane majority opinions of each channel have been qualified. Finally, the processor of each lane of the channel generates the channel majority opinion by determining if a majority of the channels have persistently generated a final majority opinion indicating that the transmitter is experiencing a fault. In other embodiments of the invention, the channel majority opinion is further processed by the processor of each lane of each channel to identify the type of fault the transmitter is experiencing, i.e., whether the fault is intermittent or constant, to identify faults in the global bus and to identify faults within the channels. <IMAGE>
Patent DE-69626621-D1 (DE)
Inventor: ZUCKERMANN N
IPC: C07K7/08
Filed: 1996-06-04
Granted: 2003-04-24
Abstract: A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two "sub-monomers" directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound  alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.
Patent DE-69629795-D1 (DE)
Inventor: YOSHIKAWA MASATOSHI
IPC: D06M101/06
Filed: 1996-09-24
Granted: 2003-10-09
Abstract: The present invention provides fiber materials, knits and textiles, nonwoven fabrics, miscellaneous daily goods or foam materials having an improved dyeability, bio-compatibility, anti-microbial activity, good bio-degradative property, and being effective for deodorizing uses, growth enhancing uses for plants and medical uses, and having anti-microbial effect produced from the chitin-chitosan viscose which is produced by a xanthogenation reaction of alkaline chitin-chitosan having a different DAC ratio through a pre- and post-immersion steps in an NaOH solution, or from a viscose in which chitin-chitosan and cellulose are solubilized. In the process for producing chitin-chitosan/cellulose fibers, films or foam materials from the chitin-chitosan/cellulose viscose, chitin-chitosan in which DAC ratio and degree of polymerization are adjusted is formed through an improved pre-immersion step in which the chitin material is immersed in a NaOH solution of high concentration at high temperature and through an improved post-immersion step in which the temperature is decreased. The chitin-chitosan/cellulose viscose is produced by a xanthogenation reaction with CS2 and by dissolving in crashed ice. The viscose obtained or a viscose in which chitin-chitosan and cellulose are solubilized in a desired ratio is used for producing fibers or films, and the viscose in which a foaming agent is added is used for producing foam materials. Span-lace process nonwoven fabrics can be also produced from these viscose.
Patent DE-69631656-D1 (DE)
Inventor: CHIPMAN STEWART
IPC: A61K45/06
Filed: 1996-06-05
Granted: 2004-04-01
Abstract: Disclosed is a method of treating osteoarthritis. The method comprises administering a therapeutic amount of debromohymenialdisine to an individual or animal with osteoarthritis. Debromohymenialdisine is able to slow the joint deterioration and cartilage degradation associated with the disease.
Patent DE-69636410-D1 (DE)
Inventor: MITCHINSON COLIN
IPC: C11D3/38
Filed: 1996-06-06
Granted: 2006-09-14
Abstract: Novel  alpha -amylase enzymes are disclosed in which one or more asparagine residues are substituted with a different amino acid or deleted. The disclosed  alpha -amylase enzymes show altered or improved low pH starch hydrolysis performance, stability and activity profiles.
Patent DE-69706307-D1 (DE)
Inventor: BARBOUR ERIC
IPC: C12N15/82
Filed: 1997-06-11
Granted: 2001-09-27
Abstract: This invention relates generally to mechanisms of gene expression in plants and more specifically to regulation of expression of genes in plants in a "tissue-preferred" manner. Regulation of expression is achieved using a transcriptional regulatory unit capable of driving expression of genes within certain tissues of a plant. Said transcriptional regulatory unit are to be utilized for driving expression of genes effective in the control of insect or other pests which threaten plants.
Patent DE-69729294-D1 (DE)
Inventor: BALAKRISHNAN BALU
IPC: H02M3/335
Filed: 1997-02-10
Granted: 2004-07-01
Abstract: A low-cost, high-voltage, flyback power supply comprising two switching transistors connected in series with the primary winding of the transformer. Such a power supply also comprises a clamping circuit in parallel with the primary of the transformer.
Patent DE-69729650-D1 (DE)
Inventor: BOTICH J
IPC: A61M25/06
Filed: 1997-12-05
Granted: 2004-07-29
Abstract: A non-reusable needle-bearing safety medical device is provided. The device is operable for inserting an intravenous catheter into a patient. The device includes a needle for piercing the patient's skin and guiding the catheter into the vein of the patient. The needle is operable in two positions, an extended position, in which the needle projects forwardly from a housing, and a retracted position, in which the needle is retracted into the barrel so that the needle is enclosed by the barrel to prevent inadvertent contact with the needle after use. A needle retainer releasably retains the needle in the projecting position against the bias of a spring that biases the needle rearwardly toward the retracted position. After use, the operator displaces an actuator to release the needle. The spring then propels the needle rearwardly into the retracted position. In this way, the device is non-reusable and the needle is shielded to prevent contact with the sharpened tip of the contaminated needle.
Patent DE-69731967-D1 (DE)
Inventor: METIVIER PASCAL
IPC: C07C65/05
Filed: 1997-10-13
Granted: 2005-01-20
Abstract: The present invention concerns a process for the preparation of a 2-hydroxybenzoic acid and of a 4-hydroxybenzaldehyde and derivatives thereof from a mixture of two phenolic compounds, one carrying a formyl or hydroxymethyl group in the 2 position, and the other carrying a formyl or hydroxymethyl group in the 4 position. The invention also concerns the preparation of a 4-hydroxybenzaldehyde from said mixture. The invention more particularly concerns the preparation of 3-methoxy-4-hydroxybenzaldehyde and of 3-ethoxy4-hydroxybenzaldehyde, respectively known as "vanillin" and ethylvanillin". The process for the preparation of a 2-hydroxybenzoic acid and a 4-hydroxybenzaldehyde and derivatives thereof is characterised in that the formyl or hydroxymethyl group in the 2 position of compound (A) in a mixture of phenolic compounds, one (A) carrying a formyl or hydroxymethyl group in the 2 position, and the other (B) carrying a formyl or hydroxymethyl group in the 4 position, is selectively oxidised to a carboxy group and optionally a hydroxymethyl group of compound (B) in the 4 position is selectively oxidised to a formyl group, thus producing a mixture of a 2-hydroxybenzoic acid and a 4-hydroxybenzaldehyde.