Patent SG-11201809164T-A (SG)
Title: Methods for selectively modulating the activity of distinct subtypes of cells
Inventor: COSTA FEJOZ CAROLINE
IPC: C12N15/86
Filed: 2017-04-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI 010111110101111 0 111 011111010111101a MEV OEN Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/182585 Al 26 October 2017 (26.10.2017) WIPO I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C12N 15/86 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/EP2017/059435 KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 20 April 2017 (20.04.2017) — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16305468.7 21 April 2016 (21.04.2016) EP (71) Applicants: ECOLE NORMALE SUPERIEURE DE LYON [FR/FR]; 15 parvis Rene Descartes, 69007 LY- ON (FR). CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3, rue Michel Ange, 75016 PARIS (FR). UNIVERSITE CLAUDE BERNARD LY- ON 1 [FR/FR]; 43, boulevard du 11 novembre 1918, 69100 VILLEURBANNE (FR). INSTITUT NATIONAL _ DE LA SANTE ET DE LA RECHERCHE MEDICALE — (INSERM) [FR/FR]; 101, Rue de Tolbiac, 75013 PARIS = (FR). = (72) Inventors: COSTA FEJOZ, Caroline; 13 All& Leopold _ Sedar Senghor, 69007 LYON (FR). VERHOEYEN, Els; 3, Rue Desboutin, 06300 NICE COSSET, Francois- _ (FR). Lok; 1 Joseph Gillet, 69004 LYON (FR). BENDER, quai Ruben; Frankenallee 64-65, 60327 FRANFURT (DE). = BUCHHOLZ, Christian; Schulstr.l0, 60594 FRANK- _ FURT (DE). ZHOU, Qi; 22 Osier Court 64 Bancroft, _ = HITCHIN Hertfordshire SG5 1LF (GB). (81) Designated States (unless otherwise indicated, for every _ kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = _ HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = — TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1-1 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, ir) GC I f ) (54) Title: METHODS FOR SELECTIVELY MODULATING THE ACTIVITY OF DISTINCT SUBTYPES OF CELLS el GC (57) : The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered 1-1 ----. envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional IN domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively © modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or N retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination. O