baber/WOPTO huggingface dataset:
Patent AU-634993-B2 (AU)
Title: Detection and quantitative determination of rna and dna
IPC: C12Q1/6853
Filed: 1989-11-21
Granted: 1993-03-11
Abstract: The method for the detection and/or quantitative determination of target RNA or DNA in an analyte sample includes the steps of: a) contacting the analyte with magnetic particles carrying a single stranded 5'-attached DNA probe capable of binding to said RNA or DNA; b) contacting the magnetic particles with an aqueous solution of a reverse transcriptase or polymerase in the presence of labelled nucleotides using the probe as a primer whereby labelled complementary single stranded DNA is formed if said RNA or DNA was present in said analyte; magnetically aggregating the magnetic particles onto a surface and removing said solution; and c) detecting the presence or absence of said label and/or determining the amount of said label. The chain length of complementary single stranded DNA is limited by, for example a predetermined amount of dideoxynucleotides being present at step (b) to limit chain synthesis to a predetermined average length or the probe binding to said DNA or RNA a predetermined distance from a chain terminating point of said DNA or RNA. A kit for performing the method is disclosed.
Patent AU-704151-B2 (AU)
Title: Device for controlling the water pressure and flow in a water supply unit
Inventor: CARMIGNANI CLAUDIO
IPC: E03B5/00
Filed: 1996-02-01
Granted: 1999-04-15
Abstract: A device for constant, automatic regulation of water pressure and flow in a water supply plant, comprising an electric pump fitted in the main water pipe, an adjustable pressure switch connected to the main water pipe, and an electronic control unit, which switches the pump on if the pressure falls short of a predetermined level or switches it off if a predetermined pressure level is exceeded. The device is characterized in that a turbine, incorporated in the water pipe, acts as a sensor, cooperating with a rotation signal transmitter which is connected to the electronic control unit in order to keep the pump switched on as long as the sensor detects a flow of water.
Patent AU-616339-B2 (AU)
Title: Method and device for quantitative chromatography
Inventor: GEORGEVICH GRADIMIR G
IPC: G01N33/558
Filed: 1990-02-01
Granted: 1991-10-24
Abstract: An improved chromatographic device and method for quantitating the activity of an enzyme utilizes a bibulous test strip as the stationary phase, an aqueous solution as the mobile phase, and a chromophore as the indicator. The enzyme activity is quantitated by transforming a substantially depletable amount of a chromogenic substrate from soluble chromogen to insoluble chromophore as the mobile phase advances, whereupon the insoluble chromophore becomes immobilized on the test strip to produce a column of color. The length and/or the intensity of the column of color are related to the activity of the enzyme. The present invention is useful for the direct determination of enzyme-analytes and for the indirect determination of analytes which can be coupled to an enzyme.
Patent AU-620206-B2 (AU)
Title: Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
Inventor: JANSSEN BERND
IPC: C07C69/92
Filed: 1990-02-09
Granted: 1992-02-13
Abstract: Diphenylheteroalkyl derivatives of the formula I <IMAGE> in which A and R<1>-R<6> have the meaning indicated in the description, and their preparation are described. The substances are suitable for controlling diseases and as cosmetic agents.
Patent AU-655377-B2 (AU)
Title: Fetal probe
Inventor: GARDOSI JASON OTTO
IPC: A61B5/288
Filed: 1993-10-25
Granted: 1994-12-15
Abstract: A fetal probe has an inflatable sac which wedges between the presenting fetal part and maternal tissues to hold a fetal sensor in position. The fetal probe is short enough to enable insertion with the amniotic membrane intact. A passage extends through the probe to facilitate intrauterine pressure measurements or amniotomy.
Patent AU-695524-B2 (AU)
Title: Method for fine comminution of mill feed material
Inventor: HEINEMANN OTTO DIPL ING
IPC: B02C7/00
Filed: 1996-04-04
Granted: 1998-08-13
Abstract: PCT No. PCT/EP96/01494 Sec. 371 Date Sep. 17, 1997 Sec. 102(e) Date Sep. 17, 1997 PCT Filed Apr. 4, 1996 PCT Pub. No. WO96/31277 PCT Pub. Date Oct. 10, 1996A method and apparatus for comminuting granular mill feed material wherein the material is delivered in a stream to a gap between two rotary grinding tracks which confront one another, one of which is positioned at a small angle to the other so that in response to relative rotation of such tracks the width of the gap decreases to a minimum at an initial rate of at least 1 m/s. At the minimum width of the gap the material is subjected to comminuting pressure greater than 50 MPa.
Patent AU-671491-B2 (AU)
Title: N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
Inventor: ARASAKI MOTOHIRO
IPC: A61K31/305
Filed: 1993-11-12
Granted: 1996-08-29
Abstract: Compounds represented by the general formula (I), <CHEM> wherein R<1> is a saturated or unsaturated, straight or branched hydrocarbon radical [wherein the number of carbon atoms in the longest straight chain of this hydrocarbon radical ranges from three to seven], or a radical of the formula -(CH2)n-Y [in which n is an integer from 0 to 4, when Y is a cyclohexyl radical, or n is an integer from 2 to 4, when Y is a lower alkoxy radical having 1 to 4 carbon atom(s) or a phenyl radical], and R<2> is a hydrogen atom or a radical easily hydrolyzable under physiological conditions, as well as hydrates or solvates of the compounds of the general formula (I), can be utilized in the treatment of tumors, They can be prepared by reacting a compound of formula R<1>-OCOCl with a N<4>-unsubstituted 5'-deoxy-5-fluorocytidine of the above formula I, wherein R<2> would stand for protecting groups, and if necessary removing the protecting groups. <IMAGE>
Patent AU-591474-B2 (AU)
Title: Serine protease inhibitors and methods for isolation of same
Inventor: THOMPSON ROBERT C
IPC: C07K14/81
Filed: 1985-12-04
Granted: 1989-12-07
Abstract: A serine protease inhibitor protein which is a purified, single-polypeptide-chain protein having at least one active site possessing serine protease inhibitor activity. This serine protease inhibitor exhibits substantial homology to the native serine protease inhibitor isolated from parotid secretions and is resistant to denaturation by heat and acids and resistant to proteolytic enzymes. The serine protease inhibitor also has the ability to re-fold into an active form after complete reduction of the disulfide bonds of the inhibitor and denaturation of all non-covalent interactions that would otherwise serve to stabilize the tertiary structure of the inhibitor after removal of these conditions. Additionally, a method for isolation of the purified serine protease inhibitor is set forth. Analogs of the serine protease inhibitors in which the amino acid sequence is varied slightly are also disclosed, which analogs variously show improved properties including improved resistance to oxidative inactivation, improved ability to inhibit pancreatic elastase, improved ability to inhibit cathepsin G, and improved ability to inhibit trypsin.
Patent AU-630443-B2 (AU)
Title: Immunoglobulin a1 proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizing against bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
Inventor: KILIAN MOGENS
IPC: A61K39/09
Filed: 1990-03-16
Granted: 1992-10-29
Abstract: Secretion of IgA1 proteases is a characteristic of Haemophilus influenzae and several other bacterial pathogens causing infectious diseases, including meningitis. Indirect evidence suggests that the proteases are important virulence factors. The iga gene encoding IgA1 protease, especially that from H. influenzae serotype b, has been cloned into Escherichia coli in which the recombinant iga gene was expressed and the resulting protease secreted. Sequencing a part of a 7.5 kb DNA fragment containing the iga gene revealed a large open reading frame (ORF) with a strongly biased codon usage and having the potential of encoding a protein of 1541 amino acids and a molecular mass of 169 kd. Putative promoter and terminator elements flanking the ORF have been identified. Comparing the deduced amino acid sequence of the produced H. influenzae IgA1 protease with that of a similar protease from Neisseria gonorrhoeae reveals several domains with a high degree of homology. Analogous to mechanisms known from the N. gonorrhoeae IgA protease secretion, there is proposed a scheme of post-translational modifications of the H. influenzae IgA1 protease precursor leading to a secreted protease with a molecular mass of 108 kd which is close to the Mr 100 kd estimated for the mature IgA1 protease.
Patent AU-642137-B2 (AU)
Title: Transparent thermoplastic moulding material and its use
Inventor: BLICKLE PETER
IPC: G02B1/04
Filed: 1990-04-12
Granted: 1993-10-14
Abstract: PCT No. PCT/EP90/00585 Sec. 371 Date Nov. 7, 1991 Sec. 102(e) Date Nov. 7, 1991 PCT Filed Apr. 13, 1990 PCT Pub. No. WO90/12043 PCT Pub. Date Oct. 18, 1990.A transparent thermoplastic molding compound consisting of 40 to 90% by weight of units derived from tetrafluoroethylene, and 60 to 10% by weight of units derived from compounds of formula I or II: CF2=CF-O-(CF2-CF(CF3)-O)m-(CF2)n-CF3(I) CF2=CF-O-(CF2-CF(CF3)-O)p-(CF2)q-COO-R(II) is particularly suitable for manufacturing the sheath of beam waveguides whose core has a higher transparency than polymethyl methacrylate.
Patent AU-584402-B2 (AU)
Title: Inductance adjustment for transformers
Inventor: NERO LEROY WILLIAM
IPC: H01F38/42
Filed: 1986-03-21
Granted: 1989-05-25
Abstract: 57 A core gap spacing arrangement for a transformer (10) includes a length of twisted wire (31, 32). The twisted wire has a relatively low packing density and is therefore compressible over a large range by using relatively low compression forces, resulting in greater ability to accurately adjust the inductance of the transformer primary winding (12).
Patent AU-670654-B2 (AU)
Title: Self-cleaning/unblocking spray nozzle
Inventor: LAIDLER KEVIN OSWALD
IPC: B05B15/525
Filed: 1993-12-01
Granted: 1996-07-25
Abstract: PCT No. PCT/GB93/02475 Sec. 371 Date Jul. 27, 1994 Sec. 102(e) Date Jul. 27, 1994 PCT Filed Jul. 27, 1994 PCT Pub. No. WO94/13409 PCT Pub. Date Jun. 23, 1994.A self-unblocking spray nozzle 10,11 in which an easily removable insert 12 is automatically moved by fluid pressure to form a spray orifice 26, and expands resiliently when the fluid pressure is interrupted. The insert 12 may include swirl vanes 33 to rotate the fluid, and may operate with a static member 14 to form an automatic anti-drip valve.
Patent AU-772151-B2 (AU)
Title: Tau as a marker for early CNS damage
Inventor: HULSTAERT FRANK
IPC: G01N33/53
Filed: 1999-09-07
Granted: 2004-04-08
Abstract: The present invention provides a new method for the early diagnosis of CNS damage in an individual, said CNS damage being caused by space-occupying lesions of the CNS, by invasion or metastasis of the CNS, by organisms, by anoxia or ischemia, by chemical agents, by physical agents, or by a combination of these mechanisms. This new method comprises the step of determining and/or quantifying the level of tau in said individual and comparing it to the level of tau in control healthy individuals.
Patent AU-732320-B2 (AU)
Title: Apparatus for indicating air traffic and terrain collision threat to an aircraft
Inventor: COWIE MARK
IPC: G08G5/04
Filed: 1998-02-26
Granted: 2001-04-12
Abstract: Includes means for monitoring the position and behavior of air traffic in the vicinity of the aircraft and generating a warning or avoidance signal for air traffic predicted to be on a collision course. The apparatus also includes means for monitoring the position and behavior of the aircraft relative to terrain in the vicinity of the aircraft flight path to generate a warning or avoidance signal for terrain features predicted to provide a collision threat. Means are provided for receiving the traffic warning signals and terrain warning signals comparing the signals and generating a combined warning or advisory signal which indicates an action for the aircraft which avoids both air traffic and terrain collisions.
Patent AU-735473-B2 (AU)
Title: Multi-compartment rehydrating container
Inventor: MARSHALL COLIN
IPC: A61K9/107
Filed: 1998-03-13
Granted: 2001-07-12
Abstract: There is disclosed a new self-rehydrating container for the production of solutions or suspensions substantially free or undesirable micro-organisms. The container is divided into at least two compartments by at least a non-permanent seal bonding the opposite walls of said container, the walls of the container surrounding at least a first compartment being watertight, the walls of the container surrounding at least one portion of at least a second compartment being semi-permeable, a water soluble or suspendible product or a concentrated solution or suspension thereof being retained in said second compartment and a water soluble or suspendible product, a drug, a nutritional suspension or powder to be put into solution or suspension is retained in said first compartment. This new self-rehydrating container allows the production of pure solutions of very low molecular weight solutes, of accurately dosed solutions, prevents the oxidation or hydrolysis of the material to be rehydrated and prevents the contamination of the rehydrated material by eventual residual bacteria.
Patent AU-675707-B2 (AU)
Title: Nucleic acid coding for a tumor rejection antigen precursor
Inventor: BRICHARD VINCENT
IPC: C12N15/09
Filed: 1994-03-09
Granted: 1997-02-13
Abstract: The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
Patent AU-707626-B2 (AU)
Title: Pyrrolopyrimidines and processes for the preparation thereof
Inventor: TRAXLER PETER
IPC: A61K31/505
Filed: 1996-06-24
Granted: 1999-07-15
Abstract: PCT No. PCT/EP96/02728 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Jun. 24, 1996 PCT Pub. No. WO97/02266 PCT Pub. Date Jan. 23, 1997Described are 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols are as defined in claim 1. Those compounds inhibit tyrosine protein kinase and can be used in the treatment of hyperproliferative diseases, for example tumour diseases.
Patent AU-658096-B2 (AU)
Title: Improved machine for applying carrier stock to containers, such as beverage cans, selectively in rim-applied or side applied carrier position
Inventor: MOORE KEVIN D
IPC: B65D67/02
Filed: 1994-06-21
Granted: 1995-03-30
Abstract: A machine (10) applies carrier stock (12) of resilient polymeric material to substantially identical containers (14), each having an upper rim (20) of a given diameter and a side wall (22) of a larger diameter. The carrier stock (12) has container-receiving apertures (18) in longitudinal rows. A conveyor (30of Figure 1) conveys the containers (14) in longitudinal rows. A wheel assembly (40) comprising two wheels (42,44) with paired jaws (52,54) receives the stock (12), stretches it transversely, and moves the stock (12) downwardly past the rims (20). The conveyor (30), the wheel assembly (40), and the jaws (52) on one wheel (42) are adjustable for applying the stock (12) selectively in a rim-applied carrier position or in a side-applied carrier position. The conveyor (30) is supported by a table (102, Figure 7) and is adjustable vertically, via spacers (130) insertable between the table (102) and a base (112). The wheel assembly (40) is adjustable longitudinally, via rollers (172) on longitudinal rails (166). The jaws (52) on one wheel (42) are adjustable transversely, via screws (80,90). <IMAGE>
Patent AU-589334-B2 (AU)
Title: Compensation method to correct thermally induced off-track errors in disc drives
Inventor: KRAUSE JAMES NORMAN
IPC: G11B5/55
Filed: 1986-11-19
Granted: 1989-10-05
Abstract: A thermal test track (- 3) is provided outside the user-accessible area on the disc. A track complete of a known frequency is then written on either side of this thermal test track, preferably half the usual track separate distance away. To develop a thermal compensation constant, the transducer (10) is moved to the thermal test track with no compensation applied. This way, any thermally induced off-track error, which would affect seeks to user-accessible data tracks, will be reflected in the off-track from the nominal position of the thermal test track. The transducer is now moved in a series of defined increments (e.g. 5) smaller than normal track-to-track steps, or "micro-steps", away from the uncompensated position of the thermal track toward one of the tracks written with the known frequency. When the data on the written track to the side of the thermal test track is detected, a note is made of the number of micro-steps the transducer has been moved. The transducer (10) is then micro-stepped incrementally in the opposite direction until the data written on the other side of the thermal test track is detected. A simple comparison of these two micro-step counts will yield the existing thermal shift, which can be converted into a thermal compensation constant for the transducer positioning mechanism by means of a simple look-up table.
Patent AU-633371-B2 (AU)
Title: Method and formulation employing type ii endoglycosidase
IPC: A61Q11/02
Filed: 1990-10-29
Granted: 1993-01-28
Abstract: Methods and formulations for removing glycoside-containing substances from surfaces by treatment with Type II endoglycosidase alone or in combination with other enzymes and/or detergents.
Patent AU-528275-B2 (AU)
Title: Imidazole derivatives
Inventor: KARJALAINEN ARTO JOHANNES
IPC: C07D263/32
Filed: 1981-02-11
Granted: 1983-04-21
Abstract: The invention provides compounds of the formula:wherein each of R<sub>1</sub>, R<sub>2</sub> and R<sub>3</sub>, which can be the same or different is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxv, amino, hydroxy or nitro; R<sub>4</sub> is hydrogen or alkyl of 1 to 7 carbon atoms; X is(R<sub>5</sub> is hydrogen or hydroxy) and n is 1-4; and their non-toxic pharmaceutically acceptable acid addition salts. These compounds exhibitvaluable pharmacological activity and are useful in the treatment of mammals, especially as anti- hypertensive agents. Furthermore, some of the compounds have proved to possess diuretic, ß-blocking activity and/or antithrombotic activity. The compounds may be made by a variety of methods and may be incorporated in pharmaceutical compositions also comprising a compatible pharmaceutically acceptable carrier.
Patent AU-634606-B2 (AU)
Title: Method for producing protein microspheres
IPC: A61K47/42
Filed: 1990-11-06
Granted: 1993-02-25
Abstract: Protein microspheres are formed by phase separation in a non-solvent followed by solvent removal. The preferred proteins are prolamines, such as zein, that are hydrophobic, biodegradable, and can be modified proteolytically or chemically to endow them with desirable properties, such as a selected degradation rate. Composite microspheres can be prepared from a mixture of proteins or a mixture of proteins with one or more bioerodible polymeric materials, such as polylactides. Protein coatings can also be made. Compounds are readillly incorporated into the microspheres for subsequent release. The process does not involve agents which degrade most labile proteins. The microspheres have a range of sizes and multiple applications, including drug delivery and delayed release of pesticides, fertilizers, and agents for environmental cleanup. Selection of microspheres size in the range of less than five microns and mode of administration can be used to target the microparticles to the cells of the reticuloendothelial system, or to the mucosal membranes of the mouth or gastrointestinal tract. Larger implants formed from the microspheres can also be utilized, especially for agricultural applications.
Patent AU-628768-B2 (AU)
Title: Stabilized solutions of psychotropic agents
Inventor: MENTINK MARIA MARTINA FRANCISC
IPC: A61P25/24
Filed: 1990-12-05
Granted: 1992-09-17
Abstract: Disclosed are stabilized aqueous preparations containing an antidepressant in admixture with a stabilizing compound such as L-methionine, D-methionine, DL-methionine, or mixtures thereof. The stabilized preparations display better stability when exposed to light, relatively high temperatures, time, and peroxides resulting in longer shelf-lives. Antidepressants which are stabilized include mirtazapine, mianserin, septiline, and amitriptyline.
Patent AU-604671-B2 (AU)
Title: Data-carrier in card form and method of producing it
Inventor: MAURER THOMAS
IPC: B44F1/12
Filed: 1987-01-27
Granted: 1991-01-03
Abstract: Record carriers on the basis of layers of plastic having features in the form of patterns or characters, the light-dark contrast of which changes from incident light to transmitted light, which are available in the form of information which is applied with the aid of a laser beam and modifies the optical characteristics of the record carrier material, the visual impression of which is different when viewed in incident light from that when viewed in transmitted light, and a method of producing said record carriers by generating information having a different visual impression by destroying a pigment which is dispersed in the substrate and absorbs and/or reflects the light with formation of light-permeable reaction products with the aid of a laser beam in the substrate.
Patent AU-606856-B2 (AU)
Title: Improvements in or relating to electric radiation heater assemblies
Inventor: SCOTT RICHARD CHARLES
IPC: H05B3/10
Filed: 1987-01-30
Granted: 1991-02-21
Abstract: An electric radiation heater assembly for a glass ceramic top cooker comprises at least one heating element (6, 7) having a substantial positive temperature coefficient of resistance, such as an infra-red lamp. A resistive assembly (4, 5) is electrically connected in series with the at least one heating element for suppressing surges of electric current due to the low initial resistance of the heating element. Switch means (2, 3) is operable a time interval of at least thirty milliseconds and preferably about 1/2 second, after a supply of electric power to the heater is energised so as to reduce the combined electrical resistance of the heating element and the resistive assembly.
Patent AU-601400-B2 (AU)
Title: Device in powder inhalators
Inventor: WETTERLIN KJELL INGVAR LEOPOLD
IPC: A61M15/00
Filed: 1987-03-02
Granted: 1990-09-13
Abstract: Device in a previously known powder inhalator intended for inhalation of an air flow which contains pharmacologically active compound in micronized form. The powder inhalator comprises a nozzle unit (2) with a nozzle aperture (2a) as well as a container unit (3) with a releasing or dosing unit (6) for delivering the active compound. The air flow generated by inhalation is at least partly aspirated through an air conduit (7) located in the container unit (3), which conduit extends from an air inlet (8), communicating with the environment, via said releasing or dosing unit (6), up to said nozzle unit (2). According to the invention, deflector devices are stationarily arranged in the container unit (3) and/or in the nozzle unit (2), said deflector devices, for example in the shape of a helical channel portion (13), being arranged to create a powerful deflecting movement for the purpose of disrupting said powder particles into the respirable particle size distribution (less than 5  mu m).