baber/WOPTO huggingface dataset:
Patent EP-3983404-A1 (EP)
Inventor: COATES DAVID ANDREW
IPC: A61P3/10
Filed: 2020-06-16
Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.
Patent EP-4032120-A1 (EP)
Inventor: LORETZ JEAN-CHARLES
IPC: H01L21/67
Filed: 2020-09-14
Abstract: The invention relates to a device comprising first and second plates (12, 14) and a device (30) for holding the plates one facing the other, the first plate (12) containing at least ten through-openings (24) and the second plate not having any through-openings.
Patent EP-4012403-A1 (EP)
Inventor: MOHAMAD ISHAK NUR SYAFIQAH
IPC: G01N30/06
Filed: 2020-03-19
Abstract: An object is to provide a high performance liquid chromatography method which enables quantitative analysis with the stability of reduced pyrroloquinoline quinone under measurement conditions maintained. The object can be achieved by the following method. A high performance liquid chromatography analysis method, comprising: a sample preparation step of preparing a sample for high performance liquid chromatography containing reduced pyrroloquinoline quinone or a salt thereof from a specimen and a separation step of separating the reduced pyrroloquinoline quinone or a salt thereof contained in the sample for high performance liquid chromatography from the specimen using interaction between a stationary phase and a mobile phase by a high performance liquid chromatography method using a reversed phase column as the stationary phase and using an eluent comprising 0.050 to 1.5% by mass of phosphoric acid and/or hydrochloric acid and 20 to 50% by volume of methanol and/or acetonitrile as the mobile phase.
Patent EP-4034151-A1 (EP)
Inventor: PELEGRIN ANDRÉ
IPC: A61P35/00
Filed: 2020-09-25
Abstract: Dans le carcinome ovarien, le récepteur de l'hormone antimüllérienne (MIS) de type II (MISRII) et la voie de signalisation MIS/MISRII sont des cibles thérapeutiques potentielles. À l'inverse, le rôle des trois récepteurs de MIS de type I (MISRI ; ALK2, ALK3 et ALK6) dans ce cancer doit être clarifié. À l'aide de quatre lignées cellulaires de cancer ovarien et de cellules de cancer ovarien isolées provenant d'ascite tumorale de patients, les inventeurs ont découvert que ALK2 et ALK3 sont les deux MISRI principaux impliqués dans la signalisation de MIS à des concentrations de MIS faibles et élevées, respectivement. De plus, des concentrations élevées de MIS ont été associées à l'apoptose et à une survie clonogénique réduite, alors que de faibles concentrations de MIS ont amélioré la viabilité des cellules cancéreuses. Enfin, les inventeurs ont montré que les siRNA de MIS inhibe l'effet pro-survie de MIS. Ces derniers résultats ouvrent la voie à une approche thérapeutique innovante pour supprimer l'effet de prolifération de MIS, au lieu d'administrer des doses élevées de MIS pour induire une apoptose de cellules cancéreuses.
Patent EP-3822923-A1 (EP)
Inventor: HABE TAKESHI
IPC: G06T1/00
Filed: 2020-03-19
Abstract: [Problem to be Solved] Provided are a maintenance support system and the like, which can prevent leakage of confidential information, etc. excluding a maintenance target and imposes few restrictions on imaging conditions. 
     [Solution] A maintenance support system 100 includes: a wearable terminal 1 including an imaging device 12; a first identifying device 31 configured to identify a first three-dimensional area TA including a maintenance target T with reference to a predetermined reference point M; a second identifying device 32 configured to identify a mask pixel area excluding an effective pixel area corresponding to the first three-dimensional area for a captured image acquired by the imaging device in a post-movement state in which the wearable terminal has moved; a processed-image generating device 33 configured to generate a processed image in which the mask pixel area is made invisible; and a communication device 34 configured to transmit the processed image to a support terminal 2.
Patent EP-3951356-A1 (EP)
Inventor: ZHANG YINGHAO
IPC: G01N21/64
Filed: 2020-03-27
Abstract: Provided are a method and apparatus for imaging a self-luminous object on a biological sample film (A); said imaging apparatus comprises a housing (1), an optical-electrical conversion element (2), and an image correction device (3); the inside of the housing (1) constitutes a darkroom space; the optical-electrical conversion element (2) is arranged in the housing (1); the optical-electrical conversion element (2) is used, when the biological sample film (A) is not inserted, for obtaining a first dark field image inside the housing (1); after affixing the biological sample film (A) to the surface of the optical-electrical conversion element (2), the optical-electrical conversion element (2) is also used for obtaining a second dark field image inside the housing (1); the image correction device (3) is used for correcting the second dark field image according to the first dark field image to obtain a target image corresponding to the self-luminous object. The imaging apparatus and imaging method can effectively and more accurately obtain a higher-definition target image of the self-luminous object; the operation process is simple and the time required for imaging is short; furthermore, the imaging apparatus has the advantages of a small structure, low cost of manufacture, convenient operation, and portability.
Patent EP-4041742-A1 (EP)
Inventor: NEELY ROBERT
IPC: C12Q1/6869
Filed: 2020-09-18
Abstract: A method for analyzing DNA comprises forming labelled DNA fragments by cleaving genomic DNA into DNA fragments, selectively functionalizing any non-methylated CpG sites present in the DNA with a linker comprising a hydrolysable moiety, and attaching a label to the linker. The method further comprises separating the labelled DNA fragments from any non-labelled DNA fragments, hydrolysing the hydrolysable moiety of the linker of the separated labelled DNA fragments so as to release the DNA fragments from the label, and sequencing the released DNA fragments.
Patent EP-4176234-A1 (EP)
Title: Detecting and improving simultaneous navigation sessions on multiple devices
Inventor: SHARIFI MATTHEW
IPC: G10L15/00
Filed: 2020-09-11
Abstract: A first computing device can implement a method for providing navigation instructions. The method includes initiating a first navigation session for providing a first set of navigation instructions to a user from a starting location to a destination location along a first route. The method also includes detecting a second computing device in proximity to the first computing device, and determining that the second computing device is implementing a second navigation session for providing a second set of navigation instructions to the destination location along a second route. Further, the method includes adjusting the first navigation session in accordance with the second navigation session.
Patent EP-3948159-A1 (EP)
Inventor: WITHAM NICHOLAS STEVEN
IPC: A61B1/05
Filed: 2020-04-05
Abstract: An otoscope includes a handle, a housing coupled to the handle and having an inlet, a laser assembly at least partially enclosed within the handle and configured to selectively project, through the inlet, a grid array of dots on a tympanic membrane of a patient, a camera supported by one of the handle or the housing and configured to selectively capture activity of the tympanic membrane, a pressure transducer supported by one of the handle or the housing and configured to selectively apply a stimulus to the tympanic membrane, a display pivotably coupled to the handle, a controller in communication with laser assembly and the display, and a microprocessor in communication with the controller, the camera, and the display. The display is configured to display the tympanic membrane in true color and a two-dimensional interpolated surface plot representing activity of the tympanic membrane in response to the stimulus.
Patent EP-4031089-A1 (EP)
Title: Motorised walker and associated control method
Inventor: PASQUI VIVIANE
IPC: A61H3/00
Filed: 2020-09-18
Abstract: The invention relates to a motorised walker (1) comprising a frame (10) having a front portion (10a) and a rear portion (10b), a pair of wheels (11), a wheel arranged to support the front portion of the frame, one of the wheels being coupled to a travelling motor (20), the motorised walker (1) being characterised in that: - the frame (10) is provided with two handrails (100) having a longitudinal axis forming an angle, with an axis perpendicular to the ground, of between 20° and 40°, each handrail being associated with a translatably movable electronic handle (200), - it comprises at least one lifting motor (30) arranged so as to move the electronic handles (200), and - at least one of the electronic handles (200) comprises one or more sensors coupled to a control module (40) configured to control the lifting motor (30) and the travelling motor (20).
Patent EP-4028687-A1 (EP)
Title: Dispositif de recouvrement pour un appareil d'alimentation en barres d'une machine-outil
Inventor: CUCCHI CESARE
IPC: F16P3/02
Filed: 2020-09-09
Abstract: La présente invention concerne un dispositif de recouvrement (1) approprié pour un appareil (2) pour alimenter en barres une machine-outil, lequel dispositif comprend : un cadre de support (3), pouvant être relié de manière rotative, par des premiers éléments de charnière (4), à une structure de cadre (5) de l'appareil d'alimentation (2), un élément de couvercle (6) relié de manière rotative, par des seconds éléments de charnière (7), au cadre de support (3). Les premiers éléments de charnière (4) et les seconds éléments de charnière (7) sont disposés sur des côtés longitudinaux respectifs (L1, L2), opposés l'un à l'autre, du cadre de support (3) et sont configurés pour permettre l'ouverture du dispositif de recouvrement (1), à volonté, à la fois d'un côté et de l'autre côté de l'appareil d'alimentation (2). Sur l'élément de couvercle (6) une ouverture de fente (8) est obtenue qui s'étend longitudinalement, configurée pour permettre à des barres de se déplacer d'un stockage auxiliaire externe à un tambour (9) de l'appareil d'alimentation (2).
Patent EP-3953471-A1 (EP)
Inventor: GOURGUECHON STEPHANE B
IPC: C12Q1/68
Filed: 2020-04-08
Abstract: L'invention concerne des compositions et des procédés permettant d'enrichir un échantillon pour des acides nucléiques d'intérêt par rapport à des acides nucléiques ciblés pour une déplétion, consistant à utiliser des différences de modification nucléotidique entre les acides nucléiques d'intérêt et les acides nucléiques ciblés pour la déplétion.
Patent EP-4041233-A1 (EP)
Title: Treatment comprising the use of fxr agonists
Inventor: BREES DOMINIQUE
IPC: A61P13/12
Filed: 2020-09-29
Abstract: The invention provides, FXR agonists for the treatment of a condition or a disease associated with mitochondrial dysfunction, e.g. a mitochondrial disease, in a subject in need thereof.
Patent EP-4013655-A1 (EP)
Inventor: WEIDENFELDER THOMAS
IPC: B61C9/50
Filed: 2020-09-29
Abstract: The invention relates to a chassis for a rail vehicle, comprising at least one chassis frame (2) to which at least one first wheel set (8) and a second wheel set (9) are coupled and to which at least one first drive unit (17) and a second drive unit (18) are connected. The aim of the invention is to achieve advantageous structural conditions. This is achieved in that a first coupling rod (24) is connected at least to the first drive unit (17) in an articulated manner and is designed to be coupleable to the vehicle body (1) of the rail vehicle in an elastic manner.
Patent EP-4035178-A1 (EP)
Inventor: BARONOV DIMITAR V
IPC: G16H50/30
Filed: 2020-09-25
Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
Patent EP-4022145-A1 (EP)
Title: Rohrförmiges bewehrungselement, verfahren zur herstellung eines bewehrungselements, globalbewehrung, verwendung eines bewehrungselements, betonbauteil und programmdatei
Inventor: VAKALIUK IURII
IPC: E04C5/07
Filed: 2020-10-02
Abstract: Die Erfindung betrifft ein rohrförmiges Bewehrungselement (1), das gitterförmig aus einem kontinuierlich angeordneten, sich kreuzenden Garn (2) ausgebildet ist, wobei die sich kreuzenden Abschnitte (3) des wenigstens einen Garns (2) durch eine Kreuzverbindung miteinander verbunden sind. Nach der Erfindung erfolgt die Kreuzverbindung des Garns (2) durch ein stoffliches Mittel oder ein mechanisches Mittel, wobei das Mittel die Scherelastizität der Kreuzverbindung, die Elastizität bei der gegenläufigen rotativen Schwenkbewegung der sich kreuzenden Abschnitte (3) um ihren Kreuzungspunkt in der Kreuzverbindung, bestimmt und damit die Dehnbarkeit des Bewehrungselements (1) in Richtung einer Längsachse bestimmt, wobei mit einer höheren Scherelastizität eine höhere Dehnbarkeit einhergeht. Die Erfindung betrifft weiterhin ein Verfahren zur Herstellung des rohrförmigen Bewehrungselements (1) durch Weben, Flechten oder Wickeln der Gitterstruktur aus einem Garn (2). Weitere Aspekte der Erfindung beziehen sich auf eine Globalbewehrung, eine Verwendung, ein Betonbauteil und eine Programmdatei.
Patent EP-3960243-A1 (EP)
Title: Pharmaceutical composition for preventing or treating treatment-resistant cancer
Inventor: KOHASHI MASAYUKI
IPC: A61P35/00
Filed: 2020-04-24
Abstract: Provided are a pharmaceutical composition for treating or preventing drug-resistant cancer by photodynamic therapy (PDT) that contains 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of these, and a method for treating or preventing drug-resistant cancer using the pharmaceutical composition.
Patent EP-3967438-A1 (EP)
Title: Joining device, joining system, and joining method
Inventor: YAMASAKI YUTAKA
IPC: H01L21/683
Filed: 2020-04-27
Abstract: A bonding apparatus configured to bond a first substrate and a second substrate includes: a first holder configured to hold the first substrate; a second holder disposed to face the first holder in a vertical direction, and configured to hold the second substrate; a processing vessel accommodating the first holder and the second holder therein; and a horizontal position adjuster provided outside the processing vessel and connected to the first holder via a support supporting the first holder, the horizontal position adjuster being configured to adjust a horizontal position of the first holder.
Patent EP-3960140-A1 (EP)
Inventor: MINAMI ASUKA
IPC: A61F13/51
Filed: 2020-04-07
Abstract: Provided is a manufacturing apparatus for manufacturing a composite stretchable member capable of improving a function of preventing cutting by reducing a defect in which an elastic member is detached from a groove of a conveying roller. The manufacturing apparatus (100) for manufacturing a composite stretchable member manufactures a composite stretchable member in which two sheets (2a, 2b) and multiple elastic members (10) are bonded to each other. The manufacturing apparatus (100) includes a guide device (110) that guides the two sheets (2a, 2b) and the elastic members (10) to a bonding device (200). The guide device (110) includes a guide member (112) that guides the elastic members (10) to respective multiple grooves (214) on an outer peripheral surface of a conveying roller (210) of the bonding device (200). The guide member (112) is provided at its leading end (114a) with multiple guide grooves (114b) for holding the corresponding elastic members (10). The guide member (112) is disposed to allow the elastic members (10) positioned between the guide grooves (114b) and the corresponding grooves (214) of the conveying roller (210) to each have a length (L1) of 30 mm or less.
Patent EP-4062451-A1 (EP)
Inventor: DUMONT GEOFFROY
IPC: H01L27/146
Filed: 2020-11-19
Abstract: L'invention porte sur un procédé de fabrication d'un dispositif de détection, comportant les étapes suivantes : • réalisation d'un plot getter (50) à base de carbone amorphe reposant sur une couche sacrificielle minérale (62) recouvrant un détecteur thermique (20); • réalisation d'une couche mince d'encapsulation reposant sur la couche sacrificielle minérale (62) et recouvrant une face supérieure et des flancs du plot getter (50); • suppression de la couche sacrificielle minérale par une première gravure chimique; • suppression d'une portion de protection (51) du plot getter (50) par une deuxième gravure chimique.
Patent EP-3975337-A1 (EP)
Inventor: WANG YIJIN
IPC: H01Q1/38
Filed: 2020-05-13
Abstract: The embodiments of the present disclosure provide an antenna element and a terminal device. The antenna element includes a target metal groove, M feeding components disposed at the bottom of the target metal groove, M feeding arms and a first insulator disposed in the target metal groove, and a target radiator carried by the first insulator. Each feeding component of the M feeding components is electrically connected to a feeding arm, the M feeding components are isolated from the target metal groove, the M feeding arms are located between the target metal groove and the first insulator, the M feeding arms are distributed along the diagonal direction of the target metal groove, each feeding arm of the M feeding arms is coupled to the target radiator and the target metal groove, a resonance frequency of the target radiator is different from a resonance frequency of the target metal groove, and M is a positive integer.
Patent EP-3986414-A1 (EP)
Inventor: FUCHS JAMES ROBERT
IPC: A61K31/54
Filed: 2020-05-22
Abstract: Disclosed herein are compounds, compositions, and methods for inhibiting a histone methyltransferase. The compounds are verticillin derivatives that exhibit anti-proliferative activity against cancer cells. The compounds, compositions, and methods can be used to treat a subject with cancer.
Patent EP-3942763-A1 (EP)
Inventor: ROWETH DUNCAN
IPC: H04L12/947
Filed: 2020-03-23
Abstract: Systems and methods are provided for performing routing in a switch network or fabric. Switches can be configured in a hierarchical topology having a plurality of groups, where switches in a group are connected to one another, and groups are connected to other groups. Routing can be performed by maintaining per-group group load information. A packet can be routed between at least two groups using the per-group group load information to effect a set of routing decisions. The set of routing decisions can be biased towards or away one or more paths.
Patent EP-4061114-A1 (EP)
Title: Verfahren zum ermitteln und optimieren des gehalts von wenigstens einem pflanzeninhaltsstoff von wenigstens einem teil einer pflanze
Inventor: KEUTER VOLKMAR
IPC: A01G7/00
Filed: 2020-11-20
Abstract: Beschrieben und dargestellt ist ein Verfahren zum Ermitteln des Gehalts von wenigstens einem Pflanzeninhaltsstoff (1) von wenigstens einem Teil einer Pflanze (3). Damit der Gehalt von Pflanzeninhaltsstoffen, insbesondere sekundären Pflanzeninhaltsstoffen, von wenigstens einem Teil einer Pflanze zweckmäßiger ermittelt und optimiert werden kann, ist vorgesehen, dass der wenigstens eine Teil der Pflanze (3) nacheinander mit Licht (7) unterschiedlicher Wellenlängen und/oder Wellenlängenbereichen bestrahlt wird und das als Antwort auf die Bestrahlung des wenigstens einen Teils der Pflanze (3) mit Licht (7) einer jeden Wellenlänge und/oder mit einem jeden Wellenlängenbereich jeweils die Chlorophyll-Fluoreszenz (9) wenigstens im Wesentlichen derselben Wellenlänge und/oder wenigstens im Wesentlichen desselben Wellenlängenbereichs gemessen wird.
Patent EP-4062577-A1 (EP)
Inventor: BAGHEL SUDHIR KUMAR
IPC: H04W72/12
Filed: 2020-11-18
Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a target user equipment (UE) may receive a channel state information (CSI) reference signal (RS) from a source UE via a sidelink communication; determine that a lower-layer determined source identifier of the source UE is included in a set of upper-layer determined source identifiers; and transmit a CSI report in a media access control (MAC) control element (CE) as a response to the CSI RS, based at least in part on the determination that the lower-layer determined source identifier of the source UE is included in a set of upper-layer determined source identifiers. Numerous other aspects are provided.
Patent EP-3980549-A1 (EP)
Inventor: SAGOO PERVINDER
IPC: C12N15/63
Filed: 2020-06-05
Abstract: Described herein are compositions and methods for modifying eukaryotic cells, for example, to express a transgene of interest and/or to produce an expanded population of cells ex vivo. Using the compositions and methods of the disclosure, a population of eukaryotic cells, such as a population of pluripotent cells (e.g., CD34+ hematopoietic stem or progenitor cells) may be transduced to express a gene of interest by contacting the cells with a viral vector, such as a lentiviral vector, and a poloxamer. Additionally, the compositions and methods described herein can be used to promote the proliferation or survival of a population of pluripotent cells (e.g., CD34+ hematopoietic stem or progenitor cells) ex vivo, for example, by contacting the cells with a poloxamer. Examples of poloxamers that may be used in conjunction with the compositions and methods of the disclosure are those having a molar mass in excess of 10,000 g/mol, as well as those having a molar mass of polyoxypropylene subunits greater than 2,000 g/mol and/or an ethylene oxide content of greater than 40% by mass.
Patent EP-4232876-A1 (EP)
Title: Configurable fault tree structure for electrical equipment
Inventor: CHEIM LUIZ
IPC: G05B23/02
Filed: 2020-12-04
Abstract: Embodiments are disclosed for adjusting at least one probability value for a subset of interconnected nodes of a configurable fault tree structure. The at least one probability value is associated with a state of at least one component of a first electrical equipment, and the configurable fault tree structure represents at least one failure mode relating to the at least one component. The adjusting is based on at least one of a detected state of the at least one component of the first electrical equipment and observed faults in a plurality of electrical equipment. Thereafter, generating an indication of the state of the at least one component based on the one or more adjusted probability values.