Patent SG-11201805768P-A (SG)
Title: Compound for use in the treatment and/or prevention of parasitic mediated diseases
Inventor: KOH HWEE LING
IPC: A61P33/06
Filed: 2017-03-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 HO 11111011101101110011111011011111011110111111 International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/155465 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/37 (2006.01) A61P 33/06 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 36/75 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/SG2017/050109 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 8 March 2017 (08.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 10201601898S 11 March 2016 (11.03.2016) SG GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: LEEWARD PACIFIC PTE LTD [SG/SG]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 207A Thomson Road, Goldhill Centre, Singapore 307640 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (SG). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: KOH, Hwee Ling; c/o NATIONAL UNWER- SITY OF SINGAPORE, Department of Pharmacy, Faculty GW, KM, ML, MR, NE, SN, TD, TG). of Science, 18 Science Drive 4, Singapore 117543 (SG). Declarations under Rule 4.17: TENG, Woon Chien Cecilia; c/o NATIONAL UNIVER- - as to applicant's entitlement to apply for and be granted a SITY OF SINGAPORE, Department of Pharmacy, Faculty of Science, 18 Science Drive 4, Singapore 117543 (SG). patent (Rule 4.17(ii)) LEE, Ying; c/o LEEWARD PACIFIC PTE LTD, 207A — of inventorship (Rule 4.17(iv)) Thomson Road, Goldhill Centre, Singapore 307640 (SG). Published: (74) Agent: YUSARN AUDREY; 24 Raffles Place, #27-01 with international search report (Art. 21(3)) Clifford Centre, Singapore 048621 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, = (54) Title: COMPOUND FOR USE IN THE TREATMENT Il 0 ir) 1 1' ir) ir) Il IN (57) : The present invention provides a compound 11 c:::: ) en below, its pharmaceutically acceptable salt, isomer ei diated disease. The present invention also provides a method 0 treatment and prevention of parasitic mediated disease falciparum, the disease mediated by the said parasite 5. isolactone. NAAAr or a using is malaria AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES belonging combination thereof for the treatment and/or prevention of a parasitic me and for manufacturing said compound. In a preferred embodiment, the parasite is to furanocoumarin the furanocoumarin derivative having core structure (A) is An - and isolating derivative having core structure (A) as giv - - said compound as well as method for Plasmodium