baber/WOPTO huggingface dataset:
Patent RU-2708917-C2 (RU)
Title: Test system for determining low-molecular markers of neurotransmitter metabolism in samples of biological fluids, method for production thereof and method for determining catecholamines and metabolites using thereof
Inventor: Makedonskaya Mariya Igorevna
IPC: G01N21/64
Filed: 2017-09-29
Granted: 2019-12-12
Abstract: FIELD: medicine; biotechnology. 
     SUBSTANCE: group of inventions relates to biotechnology and can be used in medical diagnostics and biochemical studies for quantitative detection of catecholamines and their metabolites in biological fluids. Disclosed are a test system and a method for rapid determination of low-molecular markers of neurotransmitter metabolism in biological fluid samples, as well as a method of producing a test system. Test system is a plate with chitosan film coated on the surface of the wells with immobilized peroxidase of plant origin of 0.5 to 1.5 mcm. Peroxidase is contained in amount of 2 to 16 pmol per 1 mm 2  area of film, and chitosan - from 15 to 60 mg per 1 mm 2  area of the film. Chitosan has molecular weight distribution of 50–220 kDa and degree of deacetylation of not less than 75 %. Method for rapid determination of catecholamines and metabolites thereof involves applying a sample of biological fluid on a well of a test system with subsequent introduction of hydrogen peroxide and a derivatizing agent with formation of fluorescent derivatives, excitation of fluorescence in the sample with recording of obtained signals. 
     EFFECT: invention enables to determine simultaneously several markers of neurotransmitter metabolism selected from noradrenaline, dopamine, epinephrine and their metabolites, selected from homovaniline and vanililmedal acids, in a large number of biological fluid samples with achievable reproducibility of the results of not less than 99 % and analysis time of up to 12,5 s per one sample. 
     15 cl, 6 dwg, 4 tbl, 13 ex
Patent RU-2685925-C2 (RU)
Title: Лист аустенитной нержавеющей стали, покровный элемент и способ производства для листа аустенитной нержавеющей стали
Inventor: KAWAGOE Takafumi
IPC: B21B1/22
Filed: 2016-03-16
Granted: 2019-04-23
Abstract: Группа изобретений относится к листу из аустенитной нержавеющей стали, покрывному элементу из данной стали и способу производства листа. Лист, подвергнутый дрессировке с использованием валка с матовой поверхностью после финишной холодной прокатки и светлого отжига, имеет среднеарифметическую шероховатость Ra поверхности в направлении, перпендикулярном к направлению прокатки, составляющую от 0,2 мкм до 1,2 мкм, долю площади переноса, которая является долей площади той части поверхности стального листа, на которую переносится матовый рисунок, составляющую от 15% до 70%, микроуглубления, которые сформированы на поверхности стального листа с глубиной от 0,5 мкм или более, сечением раскрыва от 10 мкми более, имеющие плотность 10,0 и менее на 0,01 мми долю сечения раскрыва 1,0% и менее на поверхности стального листа. Лист имеет пленку, сформированную на поверхности стального листа, состоящую из оксида, содержащего SiOв качестве основной составной части, и по меньшей мере Si, N, Al, Mn, Cr, Fe, Nb, Ti и O в качестве пленкообразующих элементов, отличающихся от C, причем содержание Si 10 ат.% и более, а содержание N 10 ат.% и менее. Технический результат заключается в повышении очищаемости листа, наличии матовых свойств и гидрофильности. 3 н. и 3 з.п. ф-лы, 1 ил., 4 табл.
Patent RU-2728870-C2 (RU)
Title: Polypeptides for treating oncological diseases
Inventor: BOZHENKO VLADIMIR KONSTANTINOVICH
IPC: C07K16/00
Filed: 2017-10-12
Granted: 2020-07-31
Abstract: FIELD: biotechnology; medicine.SUBSTANCE: novel polypeptide sequences capable of inhibiting RAS-GTPase activity, including a functional fragment and a transport sequence, wherein the functional fragment includes the amino acid sequence SEQ ID NO: 1 or fragment SEQ ID NO: 2. Also described is use of said polypeptide for inhibiting the MAPK/ERK signaling pathway, as well as preparing a drug for treating lung cancer.EFFECT: disclosed are polypeptides for treating oncological diseases.7 cl, 30 dwg, 3 tbl, 7 ex
Patent RU-2699333-C2 (RU)
Title: Devices and methods for administering and mixing medicinal agent, as well as training correct technique for this purpose
Inventor: SKRIMZHUR Yan
IPC: G09B23/28
Filed: 2015-06-22
Granted: 2019-09-04
Abstract: FIELD: medicine. 
     SUBSTANCE: group of inventions relates to medical equipment. Device for training users to properly mix pharmaceutical components includes a body which is located along a longitudinal axis; a power supply located in the housing; microcontroller located in housing and supplied with power supply from power supply source; user notification device and accelerometer. Accelerometer is located in housing and electrically connected to microcontroller so that microcontroller is able to detect movement and orientation of housing and indicate, by means of device, notification of user whether movement or orientation of housing, shaken during one of use of drug or training, sufficient relative to preset threshold values including value of force applied during shaking, orientation of housing and duration of such shaking. Microcontroller is also configured to detect whether the shaking of the housing has ended prematurely or the level of the shaking force has decreased to a level below a predetermined threshold, to switch to pause mode to allow the user to restart shaking during one of the use of the drug or training. Disclosed is a method for instructing a user on proper technique of mixing a drug using an educational device or a device for mixing and assisting in using the drug. 
     EFFECT: technical result consists in providing experience with respect to minimum duration and strength of shaking. 
     22 cl, 27 dwg
Patent RU-2718640-C2 (RU)
Title: Светодиодное осветительное устройство
Inventor: BEIJ MARCEL
IPC: H05B44/00
Filed: 2016-06-13
Granted: 2020-04-10
Abstract: Изобретение относится к светодиодному (LED) осветительному устройству и способу возбуждения светодиодного осветительного устройства. Техническим результатом является обеспечение регулирования силы света светодиодов осветительного устройства. Результат достигается тем, что светодиодное осветительное устройство (1) содержит светодиодную нагрузку (10), содержащую некоторое количество светодиодов (100); входные контакты (14, 14) для соединения с источником (2) питания, выполненным с возможностью подачи входного напряжения (U) на уровне (V) первичного входного напряжения; модуль (11) подъема напряжения, выполненный с возможностью подъема входного напряжения (U) до уровня выше уровня (V) первичного входного напряжения на основе входного сигнала (30) уровня регулирования силы света; и модуль (12) регулирования силы света, выполненный с возможностью уменьшения тока (I) светодиодов через светодиодную нагрузку (10), когда поднятое входное напряжение (U) превышает уровень (V) первичного входного напряжения. 2 н. и 13 з.п. ф-лы, 6 ил.
Patent RU-2749236-C2 (RU)
Title: Controller and method to control a sucker-rod pump
Inventor: AL ASSAD OMAR
IPC: F04B49/06
Filed: 2018-02-02
Granted: 2021-06-07
Abstract: FIELD: pumps. 
     SUBSTANCE: group of inventions relates to sucker-rod pumping units and their control. The controller is designed to ensure the operation of the sucker-rod pumping unit at a certain pump speed. The controller contains a processor designed to ensure the operation of the pump piston of the sucker-rod pumping unit at the first speed. The processor is also designed to determine the pump fill level for its piston stroke based on the position signal and the load signal. In addition, the processor is configured to decrease the pump speed to the second speed based on the pump fill level for its piston stroke in anticipation of an impact on fluid during the specified piston stroke and to increase the second pump piston stroke speed to the third pump piston stroke speed during the indicated piston stroke after impact on fluid.  
     EFFECT: inventions are aimed at increasing the service life of the unit components and reducing the   maintenance time and downtime of the unit.  
     23 cl, 8 dwg
Patent RU-2695540-C2 (RU)
Title: Глобальная система спутниковой связи на средних круговых орбитах
Inventor: Vygonskij YUrij Grigorevich
IPC: H04J9/00
Filed: 2016-12-12
Granted: 2019-07-24
Abstract: Изобретение относится к глобальным спутниковым информационным системам и может использоваться для предоставления услуги высокоскоростного доступа в интернет в глобальной зоне обслуживания. Техническим результатом является создание глобальной спутниковой системы передачи данных для предоставления высокоскоростного доступа в интернет. Для этого глобальная система передачи данных состоит из орбитальной группировки космических аппаратов с несколькими зеркальными перенацеливаемыми антеннами на средней круговой орбите, региональных станций для организации связи и обеспечения сопряжения с глобальной сетью интернет и наземных средств потребителей, абонентских терминалов. Предложено оптимизированное построение орбитальной группировки с равномерным распределением космических аппаратов по четырем орбитальным плоскостям, что позволяет обеспечить непрерывное глобальное покрытие всей территории Земли при минимальном числе космических аппаратов в орбитальной группировке. 1 з.п. ф-лы, 3 ил.
Patent RU-2720486-C2 (RU)
Title: Kit for dental implantation comprising dental implant and prosthetic components designed to fix single denture in upper and lower jaws of patient
Inventor: ANITUA ALDECOA EDUARDO
IPC: A61C8/00
Filed: 2016-10-26
Granted: 2020-04-30
Abstract: FIELD: medicine. 
     SUBSTANCE: invention relates to medicine and is intended for use in implant prosthetics. Dental implant kit comprising a dental implant and prosthetic components for fixing a single dental prosthesis in the upper and lower jaws of a patient and comprising a transepithelial sleeve, a first screw, an upper portion and a second screw. Upper end of the dental implant and the lower end of the transepithelial sleeve are connectable together by the first connection, and upper end of transepithelial sleeve and lower end of upper part are made with possibility of connection by means of second connection, wherein first screw is configured to pass through transepithelial sleeve and screwed into a blind threaded hole of the dental implant, attaching the transepithelial sleeve to the dental implant, and the second screw is configured to pass through the upper portion and screwed into a blind threaded hole of the first screw, attaching the upper part to the transepithelial sleeve. First connection between the lower end of the transepithelial sleeve and the upper end of the dental implant is counter-rotating. Second connection between the upper end of the transepithelial sleeve and the lower end of the upper part is a counter-coupler. Anti-rotation geometry of the first joint and counter-rotating geometry of the second joint have the same shape and aligned in the direction of the central longitudinal axis of the dental implant. 
     EFFECT: invention enables to have a non-rotating transepithelial support which, in addition to providing elongation or enlargement of the head of the implant, so that the prosthetic restoration protrudes above the gum, provides screwing of single prosthetic structures, preventing tooth turn in the patient's mouth. 
     8 cl, 15 dwg
Patent RU-2731091-C2 (RU)
Inventor: KREJDZH Sajmon
IPC: C09K23/00
Filed: 2016-11-03
Granted: 2020-08-28
Abstract: FIELD: fuel industry. 
     SUBSTANCE: invention describes an oil-in-water emulsion for use as a fuel which contains an oil phase and an aqueous phase, at least one primary surfactant, selected from one or more substances of a group consisting of fatty alkyl amines, ethoxylated fatty alkylamines, ethoxylated fatty alkyl monoamines, methylated fatty alkyl monoamines, methylated fatty alkylamines and quaternary fatty alkylamines; in range from more than 0.3 to 2.0 wt % of secondary surfactant selected from one or more ligninamines; and one or more organic acids; where the oil phase is dispersed in the aqueous phase and where the oil-in-water emulsion has the following characteristics: average droplet size (D[4.3]) in range of 3 to 15 mcm, where the average droplet size is expressed in the form of an average value with moments by volume, determined using light scattering techniques; less than 3 % of drops weight has particle size greater than 125 mcm, where drops size is determined using light scattering techniques; and viscosity higher than 100 and up to 700 MPa·s at 50 °C±10 % and 20 s −1 ±10 %, where viscosity is determined using a viscometer with coaxial cylinders. Also disclosed is a marine fuel composition based on the disclosed emulsion and a method of producing said emulsion. 
     EFFECT: technical result consists in obtaining oil-in-water emulsions having high static and dynamic stability. 
     13 cl, 10 tbl, 2 ex, 19 dwg
Patent RU-2726622-C2 (RU)
Inventor: YAMASHITA SATOSHI
IPC: A61K31/438
Filed: 2016-11-25
Granted: 2020-07-15
Abstract: FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I):(I),where ring A is a monocyclic, bridged cyclic or spirocyclic 5–12-member nitrogen-containing saturated heterocyclic group, having 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms as heteroatoms, ring B is a monocyclic or bicyclic 5–12-member unsaturated hydrocarbon or monocyclic or bicyclic 5–12-member unsaturated heterocyclic group which can be substituted with oxo, which has 0 to 3 nitrogen atoms, 0 to 1 sulfur atoms and 0 to 2 oxygen atoms as heteroatoms and which has at least one of nitrogen, sulfur and oxygen, X is O or S, R1 is nitro or cyano, R2 is halogen, R3 is amino, mono- or di (C1-C6 alkyl) amino, (C3-C6 cycloalkyl) amino or C1-C6 alkyl, R4 is halogen; nitro; cyano; carboxy; C1-C6 alkyl, optionally substituted with 1–3 substitutes selected from halogen, carboxy, C1-C6 alkoxy, hydroxy, (C2-C7 acyl) oxy, amino, optionally substituted with C2-C7 acyl, C3-C6 cycloalkyl substituted with hydroxy, or carbamoyl, optionally mono- or disubstituted with C1-C6 alkyl; C2-C6 alkenyl; C1-C6 alkoxy optionally substituted with 1 substituent selected from hydroxy, C1-C6 alkyl, optionally substituted with hydroxy, or monocyclic 6–10-member unsaturated hydrocarbon; C3-C6 cycloalkyl, optionally substituted with 1 substituent selected from C1-C6 alkyl, optionally substituted hydroxy, carbamoyl, substituted with monocyclic 6–10-member unsaturated hydrocarbon, (C1-C6 alkoxy) (C1-C6 alkyl) or C3-C6 cycloalkyl substituted with hydroxy; mono- or di (C1-C6 alkyl) amino; or carbamoyl, optionally substituted with 1 or 2 substitutes, which are C1-C6 alkyl, where, if two or more substituents are present, the substituents can be identical or different, l is integer from 0 to 2, m is integer from 0 to 2 and n is integer from 0 to 5, where, if l is equal to 2, two R2 can be identical or different, if m is equal to 2, two R3 can be identical or different and if n equals from 2 to 5, from two to five R4 can be identical or different.EFFECT: disclosed compounds are inhibitors of LSD1 and exhibit anti-tumor activity.12 cl, 39 tbl, 281 ex
Patent RU-2750389-C2 (RU)
Title: Diesel oxidation catalyst having a capture region for impurities in exhaust gases
Inventor: COLE KIERAN JOHN
IPC: B01J23/40
Filed: 2016-11-30
Granted: 2021-06-28
Abstract: FIELD: exhaust gas purification. 
     SUBSTANCE: invention relates to an oxidation catalyst and an exhaust system for purifying exhaust gases formed by an internal combustion engine, in particular a diesel engine. The invention also relates to methods and uses of an oxidation catalyst, exhaust system, or area for capturing at least one phosphorus-containing impurity and/or at least one sulfur-containing impurity in the exhaust gases formed by a diesel engine. An oxidation catalyst is described for purifying the exhaust gases formed by a diesel engine, where the oxidation catalyst contains: a substrate; a capturing material for capturing at least one phosphorus-containing impurity and/or at least one sulfur-containing impurity in the exhaust gases formed by a diesel engine; and a catalytic area located on the substrate; while the catalytic area contains a catalytic material containing a platinum group metal (PGM) selected from a group consisting of platinum (Pt), palladium (Pd) and combinations of platinum (Pt) and palladium (Pd).  
     EFFECT: invention makes it possible to reduce or prevent the deterioration of the oxidative activity of the oxidation catalyst.  
     26 cl, 12 dwg, 1 tbl
Patent RU-2732034-C2 (RU)
Title: Method and device for salt extraction
Inventor: COHEN YARIV
IPC: B09B3/70
Filed: 2016-12-19
Granted: 2020-09-10
Abstract: FIELD: chemical or physical processes. 
     SUBSTANCE: invention relates to extraction of chloride salts of sodium, potassium, chlorine and calcium. Method of extracting salts includes the following steps: obtaining a starting material which, when brought into contact with water, forms an aqueous solution containing Na, K, Cl and, optionally, Ca, treating said starting material to the enriched aqueous solution having a concentration of CaCl 2  of at least 15 % by weight, and separating said solid mixture of NaCl and KCl from said enriched aqueous solution to obtain a lean aqueous solution containing Ca and Cl ions in form of basic solutes. Device for extracting salts contains: input section and section of first stage, containing treatment device and separator of salt mixture. 
     EFFECT: invention enables separation and extraction of commercial degree of purity from CaCl 2 , NaCl and/or KCl from their mixtures using an efficient and energy-efficient method. 
     52 cl, 21 dwg, 2 tbl
Patent RU-2753613-C2 (RU)
Title: Medical device for detecting at least one analyte in physiological fluid
Inventor: VALTER KHELMUT
IPC: A61B5/145
Filed: 2017-02-03
Granted: 2021-08-18
Abstract: FIELD: medicine. 
     SUBSTANCE: group of inventions relates to medicine, namely to the determination of analyte in physiological fluid. A device, a method for use, as well as a method for assembling the device are proposed, wherein the device contains: at least one analyte sensor having an input site adapted for at least partial input into the tissue of the user’s body; at least one input cannula, inside which the analyte sensor is at least partially located; at least one electronics unit with which the analyte sensor is functionally connected; at least one case having at least one electronics compartment designed to at least partially accommodate the electronics unit, and at least one sensor compartment designed to at least partially accommodate the analyte sensor, wherein the sensor compartment forms a hermetically insulated compartment containing at least the input site of the analyte sensor and having at least one detachable upper cap and at least one detachable lower cap, wherein the detachable lower cap is designed to be separated before input, thereby opening the input site of the sensor for input, and the input cannula is attached to the detachable upper cap, which is designed to be separated after input, thereby removing the input cannula, wherein the electronics compartment at least partially surrounds the sensor compartment, and the electronics compartment and the sensor compartment form a single whole.  
     EFFECT: group of inventions provides an increase in the efficiency of determining the analyte in the physiological fluid.  
     16 cl, 15 dwg
Patent RU-2732297-C2 (RU)
Title: Derivatives of non-steroid anti-inflammatory agents
Inventor: BEZUGLOV VLADIMIR VILENOVICH
IPC: C07D209/26
Filed: 2018-11-14
Granted: 2020-09-15
Abstract: FIELD: medicine; pharmaceuticals. 
     SUBSTANCE: invention relates to a compound of general formula (I) applicable in medicine: 
     
       
     
     where R is a non-steroidal anti-inflammatory agent residue containing a carboxyl group, attached by an amide bond and representing diclofenac, ibuprofen, naproxen, ketorolac, aceclofenac, indometacin, ketoprofen or sulindac, and X is CH 2 , (CH 2 ) 3 CONHCH 2  or CH 2 CH 2 O(CO)NHCH 2 , wherein when X is CH 2 , R cannot be a residue of ibuprofen, ketoprofen or sulindac. 
     EFFECT: invention discloses novel compounds which are effective for use as an agent possessing anti-inflammatory, cytotoxic and/or neuroprotective activity. 
     2 cl, 4 tbl, 10 ex
Patent RU-2751385-C2 (RU)
Inventor: AMENDOLADZHINE MARKO
IPC: G07C5/08
Filed: 2017-08-02
Granted: 2021-07-13
Abstract: Изобретение относится к транспортным средствам. В способе обнаружения и проверки достоверности аномальных воздействий на транспортное средство получают данные о параметрах движения транспортного средства, фиксируют данные, представляющие аномальное воздействие на транспортное средство, и передают на дистанционную станцию эти данные. Применяют к базам данных аномальных воздействий истинного типа и аномальных воздействий ложного типа корреляционный фильтр, основанный на нейронной сети. На этапе применения сравнивают данные, представляющие аномальное воздействие, с данными, сохраненными в указанных базах. Если аномальные воздействия соответствуют истинному типу, подтверждают, что аномальное воздействие является истинным событием. Если аномальные воздействия соответствуют ложному типу, подтверждают, что аномальное воздействие является ложным событием. Повышается точность и надежность. 2 н. и 13 з.п. ф-лы, 2 ил.
Patent RU-2747649-C2 (RU)
Title: Комбинированные система и способ подготовки пластовой воды и морской воды для повторной закачки в подводный нефтяной пласт
Inventor: KAVALKANTI NUNES DZHOVANNI
IPC: B01D61/18
Filed: 2017-07-19
Granted: 2021-05-11
Abstract: Изобретение относится к системам подготовки воды на морских нефтедобывающих комплексах, в частности к комбинированным системе, и способу для подготовки пластовой воды и морской воды для повторной закачки в нефтяной пласт морского месторождения. Система содержит: один или более входов для воды, подлежащей подготовке; два или более модуля (20) подготовки. Причем каждый модуль содержит: один или более комплектов микро- или ультрафильтрационных мембран (20a, 20b, 20c), приспособленных для удаления нефти и твердых частиц из пластовой воды, подлежащей подготовке; или один или более комплектов нанофильтрационных мембран (20a, 20b, 20c), приспособленных для удаления сульфат-ионов из морской воды, подлежащей подготовке; и один или более выходов для подготовленной воды. При этом объем воды, подлежащей обработке, направляется к модулям (20) подготовки воды, содержащим микро- или ультрафильтрационные мембраны, или к модулям подготовки воды, содержащим нанофильтрационные мембраны, в зависимости от качества воды с точки зрения содержания нефти и твердых веществ или содержания сульфат-ионов. Технический результат заключается в обеспечении повторной закачки пластовой воды без необходимости в использовании дополнительной системы подготовки на платформе, а также в снижении сброса нефти в море и в снижении затрат на монтаж, эксплуатацию и техническое обслуживание. 2 н. и 21 з.п. ф-лы, 5 ил.