baber/WOPTO huggingface dataset:
Patent CR-20120657-A (CR)
Title: Derivados de 6,7-dihidro-5h-benzo[7]anulenos, métodos para su preparación, preparaciones farmacéuticas que los contienen y su uso para la preparación de medicamentos
Inventor: WINTERMANTEL TIM
IPC: A61K31/145
Filed: 2012-12-20
Abstract: Moduladores selectivos del receptor de estrógeno (SERM) y métodos para su preparación, su uso para el tratamiento y/o la prevención de enfermedades, así como su uso para preparar medicamentos para el tratamiento y/o la prevención de enfermedades, particularmente trastornos menstruales, osteoporosis, endometriosis, miomas, tumores hormonodependientes, terapia de sustitución hormonal y para la contracepción.
Patent CR-20150032-A (CR)
Title: Tratamientos de combinación para melanoma que comprenden la administración de cobimetinib y vemurafinib
Inventor: BRAY GORDON;
IPC: C12Q1/68
Filed: 2015-01-23
Abstract: La invención se refiere en general a los campos de biología molecular y regulación del factor de crecimiento. Más específicamente, la invención se refiere a tratamientos para afecciones patológicas, tales como cáncer.
Patent CR-20190559-A (CR)
Title: Phenyl derivatives as pge2 receptor modulators
Inventor: FRETZ HEINZ
IPC: C07D413/04
Filed: 2018-05-17
Abstract: The present invention relates to phenyl derivatives of formula (I) Formula (I) wherein (R1)n, R3, R4a, R4b, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (III) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
Patent CR-20200002-A (CR)
Title: Bicyclic ketone compounds and methods of use thereof
Inventor: PATEL SNAHEL
IPC: C07D498/04
Filed: 2018-07-12
Abstract: The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
Patent CR-20230417-A (CR)
Title: Removable water-based coating
Inventor: FRANCO CASTRILLÓN ALEXANDER
IPC: C09D111/02
Filed: 2022-02-04
Abstract: Disclosed are a removable aqueous coating, which may be coloured, and, once dry at room temperature, allows different surfaces to be protected temporarily, and production methods thereof. In particular, the present invention concerns a coating designed using only polymer materials of natural origin, which can be applied using different methods and which can be used outdoors or indoors on clear, rough and smooth substrates, except fabric materials, to provide protection and embellishment.
Patent EC-SP034524-A (EC)
Title: Derivados de pirina con actividad inhibidora de quinasa ikb (ikk-beta)
Inventor: SHIMADA MITSUYUKI
IPC: C07D401/14
Filed: 2003-03-21
Abstract: En la que R11 representa hidrógeno, alquilo C1-6-sulfonilamino, alcoxi C1-6-carbonilo, alquil C1-6-amino, de(alquil C1-6)amino, alcanoil C1-6-amino, fenialquil C1-6-amino, fenilsulfonilamino o -O-(CH2)n-R111;R2 representa hidrógeno o halógeno; R3 representa hidrógeno, -CR31R32R33, o -NR34R35; R4 es hidrógeno, carbamoílo, CN, carboxilo, etc. R5 es amino, alquilamino C1-6, di(alquil C1-6)amino, etc o una de sus sales. El compuesto presenta una actividad antiinflamatoria excelente y otras actividades biológicas.
Patent EC-SP077610-A (EC)
Title: Dispositivo destinado a la reducción de vibraciones en estructuras y sistemas mecánicos, principalmente destinado a la aislación de movimientos sísmicos, con el fin de reducir en una estructura o sistema mecánico las fuerzas y deformaciones producida
Inventor: DE LA LLERA MARTIN JUAN CARLOS
Filed: 2007-07-26
Abstract: Esta invención se relaciona en general con sistemas de reducción de vibraciones en estructuras, sistemas mecánicos y, de manera más específica, pero no en forma exclusiva, con sistemas de aislamiento sísmico en estructuras y obras civiles
Patent EC-SP088741-A (EC)
Title: Derivados de benzotriazol como agonistas del adrenoreceptor beta2
Inventor: PAIRAUDEAU GARRY
IPC: A61K31/428
Filed: 2008-09-15
Abstract: La presente invención se relaciona con compuestos de acuerdo con la fórmula (I), un procedimiento para prepararlos, los compuestos intermedios del proceso y el uso de los compuestos en la fabricación de un medicamento para su uso en el tratamiento de enfermedades tales como ARDS, enfisema pulmonar, bronquitis, bronquiectasias, enfermedad pulmonar obstructiva crónica (COPD), asma o rinitis. Los compuestos son agonistas del adrenoreceptor beta2.
Patent EC-SP109983-A (EC)
Title: Formulaciones de liposomas de compuestos de acido boronico
Inventor: HUANG ANTHONY
IPC: A61K9/127
Filed: 2010-02-22
Abstract: Se describe una composición de liposoma que comprende liposomas con un compuesto inhibidor de la proteasoma con péptido de ácido borónico atrapado en los liposomas. Más específicamente, los liposomas que tienen un compuesto de la Fórmula I ó II atrapados en el compartimento acuoso interior se cargan con un compuesto peptídico de ácido borónico, para formar un compuesto de éster boronato dentro del compartimento acuoso liposomal. En una modalidad, los liposomas tienen un recubrimiento externo de cadenas poliméricas hidrófilas y se utilizan para tratar un tumor sólido en un sujeto.
Patent EC-SP961692-A (EC)
Title: Tapa contra manipuleo indebido con una banda cautiva
Inventor: BLAKE ROBERT R
IPC: B65D51/20
Filed: 1996-03-21
Abstract: Esta invenciónm está relacionada con tapas plásticas para envases con cuellos con rosca externa, y en particular, este invento se refiere a un tipo de tapas contra manipuleo indebido con una banda cautiva. Cuando este tipo de tapa se retira del envase, la banda contra manipuleo indebido se rompe pero permanece unida a la tapa.
Patent EG-22551-A (EG)
Title: Prosthetic spinal disc nucleus having selectively coupled bodies
Inventor: NORTON BRITT K
IPC: A61F2/02
Filed: 2000-04-04
Granted: 2003-03-31
Abstract: A prosthetic spinal disc nucleus comprising a first prosthetic body, a second prosthetic body and a coupling means. The first and second prosthetic bodies each have sufficient structural integrity for maintaining a desired separation between an opposing pair of vertebrae and a volume that is less than a volume of the nucleus cavity. The coupling means selectively associates the first prosthetic body with the second prosthetic body. During use, the first prosthetic body is inserted into a nucleus cavity through an opening in an anulus. The coupling means is configured such that the second prosthetic body does not impede insertion of the first prosthetic body. The second prosthetic body is similarly implanted. Following implant, the coupling means relatively fixes the first and second prosthetic bodies to prevent subsequent movement of the prosthetic spinal disc nucleus, or any portion thereof, back through the opening in the anulus.
Patent FI-20000170-A (FI)
Inventor: MOROZOWICH WALTER
IPC: A61K31/4433
Filed: 2000-01-28
Abstract: Pharmaceutical composition comprises active, mixture of diglyceride and monoglyceride, solvents and surfactants. - Pharmaceutical composition comprises: (a) a lipophilic active agent; (b) a mixture of diglyceride and monoglyceride in a wt. ratio of 9:1-6:4 (diglyceride:monoglyceride); (c) >= 1 solvents and (d) >= 1 surfactant. The diglyceride and monoglyceride are mono- or di-unsaturated fatty acid esters of glycerol having a chain length of 16-22C. Also included is an INDEPENDENT CLAIM for a self emulsifying formulation vehicle for lipophilic active agents which comprises (b), (c) and (d) as above.
Patent FI-20001989-A (FI)
Inventor: HUHTASALO JOUKO
IPC: B27L1/08
Filed: 2000-09-08
Abstract: The present invention relates to a barking machine which comprises a frame ( 1 ), barking rotor ( 2 ), which is rotably mounted on the frame ( 1 ) and which barking rotor comprises a rotor frame ( 3 ), barking blades ( 4 ) mounted on the rotor frame ( 3 ), and a first power unit ( 5 ) mounted on the rotor frame ( 3 ) that is connected to the barking blades (T) for transferring the barking force into them. According to the invention, in the barking rotor there is arranged an adjustment device ( 6 ) movable with respect to the rotor frame, and a second power unit ( 7 ) which is mounted on the frame ( 3 ) for transmitting the barking force via the first power unit ( 5 ) to the barking blades ( 4 ). This solution enables one to adjust the barking depth of the barking blades without stopping the barking rotor.
Patent FI-20205586-A (FI)
Title: Coating of particulate materials
Inventor: PUDAS MARKO
IPC: C23C16/455
Filed: 2019-06-06
Abstract: Chemical deposition reactor assembly 100 configured for formation of coatings on surfaces of particulate materials, such as powders and/or fibers, by chemical deposition is provided, said reactor assembly comprises a reaction chamber 101; at least one reactive fluid intake line 21 configured to mediate a flow of reactive fluid 12 into the reaction chamber, and an inert fluid delivery arrangement comprising an essentially tubular enclosed section 31 configured to pass through the reaction chamber 101 and loadable with the particulate substrate 10, said tubular member comprising at least one aperture 31A defining a volume, where the particulate substrate within the enclosed section 31 is exposed to the flow of reactive fluid 12. In said tubular enclosure 31, a flow of inert fluid 11 is mediated through the particulate substrate 10 towards the aperture 31A such, that, within the volume exposed to the flow of reactive fluid 12, the flow of inert fluid 11 encounters the flow of reactive fluid 12, whereby a coating is formed at the surfaces of particulate substrate within said volume.
Patent FR-1549827-A (FR)
IPC: C07C43/12
Filed: 1967-12-26
Granted: 1968-12-13
Abstract: 1,198,840. Ethers and thioethers. MONSANTO CO. 27 Dec., 1967 [27 Dec., 1966], No. 58621/67. Heading C2C. [Also in Division C3] Ethers and thioethers are prepared by reacting compounds of the formulµ R(F) n  and M b [X(Z) d ] c  in the presence of a dipolar aprotic solvent, where R is optionally substituted hydrocarbon; M is an alkali or alkaline earth metal; X is O or S; Z is optionally substituted aryl or heterocyclyl of 3-10 carbon atoms and 1-4 oxygen, sulphur and/or nitrogen atoms; n and b are at least 1, c is 1 to b times the valence of the metal M, provided that when M is an alkali metal c is 1, d is 0 or 1, and is 1 when X is S, and when d is 1, M is an alkaline earth metal.
Patent FR-1604588-A (FR)
Title: Piezoelectric ceramic - contg cobalt and tantalum for filters frequency controllers etc
IPC: C04B35/51
Filed: 1968-11-13
Granted: 1971-12-06
Abstract: Piezoelectric ceramics consisting of solid solns. from the ternary system Pb(Co1/3Ta2/3)O3 - PbTiO3 - PbZrO3; in partic. Pb(Co1/3Ta2/3)o.25TiO.43Zro.32O3 and Pb(Co1/3-Ta2/3)0.125Ti0.435Zr0.44P3 for which the coupling coefficient is 0.55 with high mechanical Q. Little loss of PbO occurs during sintering so that no special atmos. is required.
Patent GB-1040387-A (GB)
Abstract: 1,040,387. Valves. AGFA A.G. June 2, 1965 [June 5, 1964], No. 23528/65. Heading F2V. An opening 2 in the wall of a photographicprocessing tank 1 is closed by a bolted-on cover 3 that carries a tap having a horizontal pipe 9 with a depending portion 10, the lower end of which coacts with a movable closure member 13 embodying a resilient seal 14, a tensioning stirrup 12 and a guide pin 17. The upper part of the latter engages a notch 19 in a pair of cams 15 on the pipe 9, which cams have a central spiral part, and straight surfaces tangential thereto. The portion 10 discharges into a channel 18. The tap is opened by pushing the stirrup out of the notch 19.
Patent GB-1047230-A (GB)
IPC: F02K9/48
Abstract: 1,047,230. Rocket engines. ROLLS-ROYCE Ltd. March 7, 1960 [March 11, 1959], No. 8500/59. Heading F1J. In a rocket propulsion motor, a fail safe system is provided such that when a fault occurs the valves controlling the flow of fuel and oxygen to the thrust chamber are closed, if the rocket is on the ground, and are maintained open once the rocket has left the launching area. In addition, the fuel and oxygen feed to a gas generator, within the rocket, supplying the fuel and oxygen pump turbine, is similarly controlled. Both systems may be shut down during flight by the remote firing of cartridges to effect valve closure. The motor thrust chamber is supplied with liquid oxygen and fuel, the latter first cooling the chamber before entering through spray nozzles. The chamber is shaped in throat form and, has a pyrotechnic igniter. To limit the rocket acceleration, as the mass is reduced by the consumption of fuel, the flow of oxygen is automatically controlled by a valve having an acceleration sensitive member. The motor is started from fuel and liquid oxygen tanks of the ground installation, pressurised with nitrogen, and after the commencement of combustion in the chamber, fuel and oxygen at low pressure flow from the rocket tanks into the chamber. An ignition detector in the chamber causes fuel and oxygen to be directed to the gas generator from the ground tanks where they are ignited to drive the rocket fuel and oxygen pumps which raise oxygen and fuel supply pressure to the thrust chambers to full value. At 80% full pressure the ground tanks are de-pressurised and the rocket released. To maintain accuracy in the flight path, the liquid levels in the fuel and oxygen tanks are sensed and the fuel flow throttled to maintain the required fuel-oxygen flow. The oxygen control valve 163, Fig. 11, compress the plate 164 and is controlled by the piston 172. Nitrogen from the ground installation urges 172 against spring 185, to open 164. If the valve fails during flight, it remains open due to the locking of fingers 174, behind shoulder 175. To interrupt the oxygen supply during flight, a remotely fired cartridge generates gases which are applied, through pipe 181 to the opposite side of 173. Member 177 is lifted, fingers 174 are freed and piston 172 forced downwards to close 164. A "fail safe" on the ground is effected by the introduction of nitrogen into the space above 172 by ground fault detector equipment. The fuel control valve, (Fig. 12, not shown) operates in a similar manner and in addition incorporates a fuel throttling system operated by an electrically adjusted valve energised in dependence upon signals representing the relative levels in the fuel and oxygen tanks.
Patent GB-1053458-A (GB)
IPC: B65H1/04
Abstract: 1,053,458. Feeding and delivering sheets. ZEUTHEN & AAGAARD A.S. April 13, 1965 [April 18, 1964], No. 15805/65. Headings B6B and B6H. In a printing machine, particularly an office duplicating machine, the side guides 16, 17 for the pile of sheets to be fed into the machine, and the side guides 23, 24 for the delivery table which receives the printed sheets, can be simultaneously adjusted to suit the width of the sheets. As shown in plan, the sides 1, 2 of the machine are connected by rods 3, 4 on which tubular sleeves 5, 6 can slide, and secured to the sleeves 5, 6, respectively, are carrying members 7, 8 which extend from the entrance of the machine to the discharge end. The carrying members 7, 8 have nuts 9, 11 engaged by screws 10, 12 which are rotatable through gears when knobs 13, 14, respectively, are rotated, and these knobs can be rotated together, or independently to adjust the members 7, 8. The side guides 16, 17 for a sheet pile 15, Fig. 1 (not shown), are secured to the members 7, 8, and presser &c. members 21, 22, which facilitate the separation of the top sheet, are arranged on the members 7, 8. At the delivery side of the machine, a side guide 23 and a pile jogger 24 are pivotally secured, respectively, to the members 7, 8, to receive the printed sheets, and one member may also carry an end jogger. Discharge rollers 26, 27 slidably mounted on a shaft 25 have collars engaged by lugs 30, 31 fixed on the carrying members 7, 8, respectively; and stripping members 32, 33, which strip the printed sheets from the printing cylinder 19, are mounted on shafts carried on supports secured to the carrying members 7, 8: thus, when the carrying members are adjusted to suit the width of sheets, the rollers and strippers are also adjusted. The duplicating machine shown has a stencil mounted on a master cylinder 19 and a roller 18, and the cylinder 19 no-operates with a pressure roller 20. The sheet pile 15 is adjusted relatively to the stencil to arrange the printing on the sheets.
Patent GB-1053465-A (GB)
IPC: B64F1/305
Abstract: 1,053,465. Gangways. WOLLARD AIRCRAFT SERVICE EQUIPMENT Inc. Oct. 19, 1964 [Nov. 29, 1963], No. 42600/64. Heading B7J. A gangway between a building 3, Figs. 1, 2, and a vehicle such as an aircraft 5 comprises a portion 7 fixed to the building, a portion 11 supported at one end by a telescopic wheeled truck 17 and at the other end being provided with arms 47, Fig. 4, which are pivotally connected to pairs of ears 43, Fig. 2, on an intermediate portion 9 so that the portion 11 may pivot in a vertical plane relative to the portion 9, arid the portions 9 and 11 may pivot together in a horizontal plane about a vertical axis through the stand 15, the vertical axis through the stand intersecting with the horizontal axis through the ears. The portion 9 has flexible sides 65 which may roll up in a vertical plane when the portions 9 and 11 swing in a horizontal plane, and bridge plates 53 and a jointed ramp 57 are provided. The end portion 13 is swingable about a vertical axis by power means, and-doors 21, 25 and stairs 23 are provided. The portion 9 is covered by a roof 79, Fig. 4, supported on a pivot 75 on an extension 73 of the roof 69 of the portion 7.
Patent GB-1053488-A (GB)
IPC: H01H50/54
Abstract: 1,053,488. Electromagnetic relays. ALLENBRADLEY CO. Dec. 15, 1964 [Dec. 26, 1963], No. 50997/64. Heading H2B. A magnet assembly comprising a moulded coil block 6 (Fig. 6, not shown), a yoke 7 (Fig. 7, not shown) and an armature 8 (Fig. 8, not shown) are removable as a unit from a channelshaped base 5 by sliding the assembly from right to left along the channel. When inserted in the base 5 the coil block 6 is urged upwards by spring 17 of the base so that vertical edges 23 of tapered cam surfaces 21, 22 engage behind ledges 13 struck inwardly from the upstanding limbs of the channel 5. Movement of the coil block in this position is prevented by the provision of further ledges 12 which co-operate with corners 24 of the block. The yoke 7 and armature 8 are inserted into two holes 25 in the block from the bottom and top respectively and the yoke is cushioned by a shock absorbent pad 19 (Fig. 2, not shown) on the base 5 beneath it and by a pad 27 (Fig. 4, not shown) on the block 6 above it. The armature is biased upwards by left-hand and right-hand coil springs to prevent turning due to spring torque. A pivoted tab 35 on the block retains the armature in position. Two contact housings 2, 3 (Figs. 17 and 18, not shown) are mounted in superposed relation of the coil block and each includes four contact sets in separate containers. A double-ended push-button protrudes from each container and each container may be reversed to change it from normally open to normally closed or vice versa. A manual actuator 45, 67 is provided which acts directly on the armature. The contact assembly is more fully described in copending Specification 1,053,489.
Patent GB-1054558-A (GB)
IPC: E02F3/92
Abstract: 1,054,558. Dredgers. LOHMANN & STOLTERFOHT A.G. Sept. 27, 1963 [Nov. 16, 1962], No. 38135/63. Heading B7A. [Also in Division E1] The cutting head 8 of a dredger is driven by the output shaft 7 of a toothed wheel reduction gearing having at least two input shafts (18a), (18b) (Fig. 2. not shown), the input shafts being driven by two hydraulic motors 6a, 6b, connected in parallel and driven by a common hydraulic pump or series of parallel connected pumps 13. Fig. 1 shows how a single motor 9 serves to drive pump 13 and propel the vessel 1. The head 8 is mounted on a jib 3, disposed in a recess 2 in the hull and pivotable by crab 17 about horizontal axis 4. Power regulation is by regulating pump(s) and/or motors. and pressure relief valves prevent overloading. Pumps in parallel may be driven by a common shaft, by collective gearing or separate motors.
Patent GB-1060564-A (GB)
Abstract: 1,060,564. Variable capacitors. GLOBEUNION Inc. Feb. 25, 1964 [March 6, 1963]' No. 7729/64. Heading H1M. The rotor of a capacitor is formed by providing a conductive portion on the rotor, reinforcing the rotor, and subsequently reducing the thickness of that part of the rotor on which the conductive portion is provided. In one form, Fig. 3, the rotor 16 is formed with an annular groove 45 in which the rotor plate 32 is formed. The groove is then filled with reinforcing material 48, such as glaze, thermoplastic material or thermosetting material, and the thickness of the rotor reduced to, for example, 0-009-0-011 inch between the movable electrode 32 and the fixed electrode 14. In a second form, Fig. 7, .the movable electrode .is formed as a conductive paint 68 sandwiched between the dielectric layers 64, 66, and the thickness of layer 66 is subsequently reduced by grinding. The other surface of layer 64 is provided with a conductive coating 74, for external connections, which contacts electrode 68 via notch 70. In a modification of this rotor, Fig. 9, layer 88 is provided with two interconnected conductive films 92, 94, layer 86 is provided with the movable electrode 90, and the two layers are joined by adhesive 96.
Patent GB-1084304-A (GB)
IPC: B65G27/20
Abstract: 1,084,304. Vibratory mechanisms. W. BARKER. Aug. 20,1965 [Sept. 1, 1964], No.35683/64. Heading F2X. A reciprocatory screen, conveyer 10 or the like has a driving mechanism which includes at least two pairs 13, 14 of unbalanced rotatable masses arranged so that the two masses of each pair rotate in opposite directions at the same speed and at least one pair of masses rotate at a speed different from the other pair or pairs of masses. The conveyer is supported by hangers 12 and the two masses of each pair are laterally spaced while the two pairs are connected by gearing 18, 20, 21 so that the pair 14 has twice the speed of the pair 13, a single electric motor 15 being connected to the gearing through a worm gear 16. The phase relationship between the masses may be adjusted to alter the characteristics of the vibrations which are non- uniform so that the force applied to the material on the conveyer is greater in one direction than in the other. The material may also be made to circulate during advancement.