baber/WOPTO huggingface dataset:
Patent EA-013818-B1 (EA)
Title: Multi-substituted selective androgen receptor modulators and methods of use thereof
Inventor: DALTON JAMES T
IPC: A61P5/28
Filed: 2003-02-24
Abstract: This invention provides androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). The SARM compounds represented by the structure of formula IV:wherein X is O; G is O or S; T is OH; R is (C-C)-alkyl, halo(C-C)- alkyl, dihalo(C-C)--alkyl, trihalo(C-C)--alkyl, CHF, CHF, CF, CFCF; phenyl, halogen, (C-C)-alkenyl or OH; Ris CH, Ris F, Cl, Br, I, CN, NO, COR, COOH, CONHR, CF, Sn(R); Z is NO, CN, COR, COOH, or CONHR; Q is (C-C)-alkyl, halogen, CF, CN C(R), Sn(R), N(R), NHCOCH, NHCOCF, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH, NHCSCF, NHCSR NHSOCH, NHSOR, OH, OR, COR, OCOR, OSOR, SOR, SR; wherein p' is an integer of 1-4; m is an integer of 1-3, and/or isomer, pharmaceutically acceptable salt, hydrate or N-oxide or any of their combinations. Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; and/or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
Patent EA-009680-B1 (EA)
Title: Immunomodulating heterocyclic compounds
Inventor: MATHEWS IAN RICHARD
IPC: A61P19/02
Filed: 2004-03-10
Abstract: The compound4- (6-fluoro-3-oxo-1, 3-dihydro-pyrazolo [4,3-c] cinnolin-2-yl)-N- (2, 2-difluoro-ethylyl)-benzamide, of formula (A)or a pharmaceutical or veterinarily acceptable salt can be used for preparing immunomodulating agents.
Patent EA-009227-B1 (EA)
Title: THIN STRIPS OR FOILS OF AlFeSI ALLOY
Inventor: DANIELOU ARMELLE
IPC: C22C21/02
Filed: 2004-07-19
Abstract: The invention relates to a thin strip or foil, having a thickness of 6 to 200 mkm, preferably, of 6 to 50 mkm, and composed of an alloy containing (in weight %) Si: 1.0 to 1.5, Fe: 1.0 to 1.5, Cu < 0.2, Mn < 0.1, other elements < 0.05 each up to a total < 0.15, the remainder being Al. The annealed thin strip or foil has a tensile strength R> 110 MPa for a thickness > 9 mkm and > 100 MPa for a thickness of 6 to 9 mkm, and an elastic limit R> 70 MPa. Preferably, said alloy has a silicon content of 1.1 to 1.3 % and an iron content of 1.0 to 1.2 %. The aforementioned thin strips or foils may be used especially for the production of multilayer composites, overcaps for bottles or aluminium wrappings.
Patent EA-010024-B1 (EA)
Title: Gaming machine
Inventor: OKADA KAZUO
IPC: A63F5/04
Filed: 2006-03-03
Abstract: It is an object to provide the player with an incentive to play the game repeatedly by varying an effect display mode since the effect display mode to notify the information relating to the game can be selected at the player's choice such that the player's taste and wish may be reflected on the mode. A gaming machine 1 comprises: a display device 4 for displaying a circumferentially-arranged image having a plurality of symbols arranged circumferentially; and a reading device 19 for reading the identification information from a game article storing the identification information, wherein an array change of the plurality of symbols in the circumferentially-arranged image is conducted in a case where the identification information is read; and wherein the display device 4 displays a changed circumferentially-arranged image after the array change.
Patent EA-008932-B1 (EA)
Title: Process for separating products of propane and butane dehydrocyclodimerization
Inventor: FALKEVICH GENRIKH SEMENOVICH
IPC: C07C15/00
Filed: 2006-02-07
Abstract: A process for separating products of C-Cparafins dehydrocyclodimerization can be used in oil processing and petrochemistry.The process for separating products of C-Cparafins dehydrocyclodimerization comprising hydrogen, methane, propane, butane and C-Caromatic hydrocarbons comprises partial condensation of Ccomponents, separation thereof at least in one zone of vapor-liquid separation to yield liquid phase stream, comprising C, Chydrocarbons an a aromatic hydrocarbons, and vapor phase stream containing hydrogen, methane and ethane and Chydrocarbons, separation of Chydrocarbons from the liquid phase stream and concentrate of Caromatic hydrocarbons. For separation of aromatic hydrocarbons from the resulted vapor phase stream it is contacted with adsorbent providing absorption at least part of aromatic hydrocarbons to yield vapor phase stream depleted by aromatic hydrocarbons in the predetermined rate. The adsorbent saturated by aromatic hydrocarbons is regenerated with blow off gas at increased temperature, wherein part of the vapor phase stream depleted by aromatic hydrocarbons is used as blow off gas, wherein blow off gas saturated with aromatic hydrocarbons they are condensed and separated at the vapor-liquid separation.
Patent EA-010568-B1 (EA)
Title: 2,6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
Inventor: CRESPO CRESPO MARIA ISABEL
IPC: C07D403/04
Filed: 2004-12-14
Abstract: 4-Aminopyrimidine derivatives of formula (I)wherein heteroaryl groups, including pharmaceutically acceptable salts thereof, wherein Rand Rare adenosine A2A receptor antagonists useful in the treatment of movement disorders such as Parkinson's disease.
Patent EA-011134-B1 (EA)
Title: Method of automatically controlled packing of sectional heating radiators in transfer pallet
Inventor: KAJROVICH CHESLAV ALBINOVICH
IPC: B65G57/16
Filed: 2007-03-30
Abstract: The present invention relates to methods of packing of the articles of a special shape, particularly to the methods of automatically controlled packing of sectional heating radiators into a transfer pallet with its subsequent bundling.The claimed method of the automatically controlled handling of sectional heating radiators into transfer pallet comprises of supply of the first radiator, its bias in direction perpendicular to vertical axis of the radiator section, for the distance equal to 1/4 of the width of the radiator section and fixing, then the following radiators are supplied, each following radiator being supplied, excluding its bias in direction perpendicular to vertical axis of the radiator section, relative to the original position of the previous radiator till the moment of its contact to the previous radiator, and after packing of the set amount of the radiators the load being bundled.The use of the said method allows (due to sections tilt angles and radiators weight) to pack automatically the radiators in the required checkerboard without supplementary machinery and devices use, which results in significant electricity saving. Moreover, due to the fact, that a column of one radiator is located in the hollow of the other one, the radiators are not side-shifted and the transfer pallet has a resistant stable form.
Patent EA-014822-B1 (EA)
Title: A radiator bracket
Inventor: THORN HAAKAN
IPC: F24D19/02
Filed: 2008-12-17
Abstract: A bracket for mounting a radiator on a wall comprises an anchorage rail (1) and first (10) and second engagement members. The anchorage rail (1) is fixedly secured on the wall, and the engagement members (10) cooperate with the radiator or an anchorage disposed thereon. The first engagement member (10) is movable and spring-biased towards the second engagement member. The spring-biasing takes place by spring means (13) comprising a compression spring disposed inside the first engagement member (10).
Patent EA-014675-B1 (EA)
Title: Method of using il6 antagonists with proteasome inhibitors
Inventor: ZAKI MOHAMED
IPC: A61K38/00
Filed: 2006-12-08
Abstract: The invention is directed to a method of treating a cancerous disorder or condition, or an IL-6 related disorder or condition, in a mammal in need of such treatment, which comprises co-administering a proteasome inhibitor in combination with an IL-6 antagonist
Patent EA-015341-B1 (EA)
Title: Novel nematode compositions
Inventor: ASSARAF MENACHEM
IPC: A01N47/28
Filed: 2007-01-08
Abstract: Novel nematode compositions and formulations, containing a phosphorous-containing compound and a nitrogen-releasing compound, are disclosed. These novel compositions exhibit a synergistic pesticidal activity and are particularly useful in treating pests such as nematodes (including root nematodes). Methods utilizing these compositions for controlling pests, articles-of-manufacture containing same and processes of preparing same are further disclosed.
Patent EA-016982-B1 (EA)
Title: Chain extender composition, a polymer formed therefrom and process for producing the polymer
Inventor: WIGGINS PAUL L
IPC: C08G18/10
Filed: 2007-09-21
Abstract: This invention provides chain extender compositions. These compositions comprise: (i) an aliphatic secondary diamine, and (ii) a component selected from the group consisting of: (a) a cycloaliphatic primary diamine; (b) an aliphatic secondary diamine; (c) an aliphatic secondary diamine and an aliphatic primary diamine; (d) an aliphatic diimine; and (e) a combination of any two or more of (a) through (d), with the proviso that when (ii) is (a), (i) is a noncyclic aliphatic secondary diamine. Processes for producing polyurethanes, polyureas, and polyurea-urethanes are also provided.
Patent EA-017341-B1 (EA)
Title: Method of producing package of absorbent articles and package of absorbent articles obtained by said method
Inventor: OBA KENJI
IPC: B65D85/07
Filed: 2008-11-20
Abstract: The present invention includes the following steps. In a first step, first and second breast milk absorbent pads 2(i), 3(i) are fed onto wrapping sheet web 29. In a second step, the first pad 2(ii) is fed so as to be displaced from a transverse center line 32 toward an upper end 30 by 1/4 of a dimension H thereof as measured in a longitudinal direction Y, and the pad 2(ii) is fed so as to be displaced from a transverse center line 32 toward an lower end 30 by 1/4 of a dimension H thereof as measured in a longitudinal direction Y. In a third step, the pads 2, 3(iii) are respectively folded back from the upper and lower ends 30, 31 toward the transverse center line 32 in two-ply fashion. In a fourth step, the upper and lower ends of the wrapping sheet web 29 are folded back toward the transverse center line 32. In a fifth step, a joint zone 20 is formed between the pads 2, 3(v) and these two pads 2, 3(v) is cut apart along a cutting line 33.
Patent EA-023836-B1 (EA)
Title: Crop pick-up
Inventor: KIDD BRUCE
IPC: A01D65/02
Filed: 2012-06-14
Abstract: A crop pick-up frame has mountings for attachment to the feeder house of a combine harvester with a pick up assembly having transverse tine bars parallel to a transverse axis which move in a composite movement both around the transverse axis and parallel to the transverse axis such that each tine describes a closed path around the transverse axis and inclined to a radial plane of the transverse axis. Behind the bars is a belt conveyor followed by a converging auger where the belt conveyor is offset to one side relative to the bars so that the ends of the bars define a first path of travel at a first end of the bars and a second path of travel at a second end of the bars and the belt conveyor is offset such that one side edge extends beyond an outermost part of the second path of travel.
Patent EA-020600-B1 (EA)
Title: Trans-4-[[(5s)-5-[[[3,5-bis-(trifluoromethyl)phenyl]methyl](2-methyl-2h-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1h-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid
Inventor: CHEN XINCHAO
IPC: C07D403/12
Filed: 2010-06-28
Abstract: Compounds of a formulaentitled trans-4-[[(5S)-5-[[[3,5-bis-(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof, hydrate, and hydrate in crystalline form; pharmaceutical formulations; and methods of use are disclosed.
Patent EA-028218-B1 (EA)
Title: Apolipoprotein a-iv as an antidiabetic peptide
Inventor: TSO PATRICK
IPC: C07K14/775
Filed: 2012-01-19
Abstract: Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. The pharmaceutical composition includes apolipoprotein A-IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.
Patent EA-029340-B1 (EA)
Title: CHIRAL N-ACYL-5,6,7-(8-SUBSTITUTED)TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Inventor: HOVEYEDA HAMID
IPC: C07D487/04
Filed: 2012-10-03
Abstract: The present invention relates to compounds of Formula Iand their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7-(8-substituted)tetrahydro[1,2,4]triazolo[4,3-a]pyrazines using N-spprotective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
Patent EA-029542-B1 (EA)
Title: 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE DERIVATIVES FOR TREATING SPINAL MUSCULAR ATROPHY
Inventor: QI HONGYAN
IPC: C07D239/70
Filed: 2013-02-08
Abstract: Provided herein are compounds of formula (IIa1)wherein R, R, R, Rand Rare defined in the claims, compositions thereof and uses therewith for treating spinal muscular atrophy.
Patent EA-030114-B1 (EA)
Title: Modular laser apparatus
Inventor: DUBOST BRICE
IPC: G02B27/14
Filed: 2014-10-13
Abstract: The invention relates to a laser apparatus including a plurality of laser modules, each generating a laser line at a working surface, wherein said laser modules are juxtaposed such that the laser lines generated by the modules combine into a single laser line, wherein each laser module includes at least one means for generating a laser line, wherein said laser apparatus is characterized in that the or each laser line generation means includes two alignments (1a, 1b) of laser diode arrays (2), each emitting a focused laser beam (3a, 3b), wherein both alignments (1a, 1b) are placed parallel to each other so that the arrays (2) are staggered, wherein both sets of parallel laser beams (3a, 3b), respectively generated by the two array alignments (1a, 1b), are joined into a single laser line (8) by means of a set of mirrors (4, 5), wherein the alignments of laser diode arrays (1a, 1b) and mirrors (4, 5) are placed such that both sets of laser beams (3a, 3b) travel on an optical path of the same length before being joined into a single laser line (8).
Patent EA-034829-B1 (EA)
Title: Structural body having liquid layer on the surface thereof
Inventor: IWAMOTO SHINYA
IPC: B65D65/40
Filed: 2015-05-13
Abstract: A structural body having an underlying surface of a resin and holding a liquid layer on the underlying surface, wherein fine particles are dispersed in the resin forming the underlying surface to suppress the permeation of the liquid layer. The structural body effectively suppresses the extinction of the liquid layer with the passage of time.
Patent EA-037271-B1 (EA)
Title: Multi-peptide t specific immune therapy for treatment of brain metastases
Inventor: COSTANTINI DOMINIQUE
IPC: A61P35/04
Filed: 2014-11-06
Abstract: The present invention relates to a peptide vaccine composition OSE-2101 for treatment of brain metastases in HLA-A2 positive patients.
Patent EA-038594-B1 (EA)
Title: Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
Inventor: GEDULIN BRONISLAVA
IPC: A61P1/16
Filed: 2012-10-26
Abstract: Provided herein is the use of an apical sodium-dependent bile acid transporter inhibitor (ASBTI) of said structures or a hydrate or solvate thereof for treating or ameliorating a cholestatic liver disease. Also provided is a method of treating or ameliorating a cholestatic liver disease by administering to a subject in need thereof a therapeutically effective amount of said ASBTI. The cholestatic liver disease is selected from progressive familial intrahepatic cholestasis (PFIC), PFIC type 1, PFIC type 2, PFIC type 3, Alagille syndrome, primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), biliary atresia or intrahepatic cholestasis of pregnancy (ICP).
Patent EA-036936-B1 (EA)
Title: Method for surgical treatment of hearing disorder in a patient with congenital ear anomaly
Inventor: GREBEN NIKOLAY IVANOVICH
IPC: A61F11/00
Filed: 2018-08-28
Abstract: The invention relates to medicine and can be used for treatment of patients with congenital ear anomalies (congenital defects) provoking hearing disorder due to the missing auricle and the external auditory canal. The objective of the invention is to reduce the period of recovery and rehabilitation with simultaneous elimination of any additional anesthesia care. The invention essence is simultaneous installation of an auricle prosthesis and a BAHA hearing implant, and combination of aesthetic and hearing improvement stages, which will make it possible to be limited to one anesthesia care, and will also reduce the time of patient rehabilitation. The first stage of operation is the preparation of a place for location of a silicone auricle, and installation of titanium implants and supports for the auricle; the second stage is installation of implants and a support of the implanted bone-anchored hearing aids (BAHA) system. One month later after the treatment, the silicone auricle is secured to supports, and primary connection and adjustment of BAHA sound processor are carried out.
Patent EA-038849-B1 (EA)
Title: Method of pressure testing
Inventor: ROSS SHAUN COMPTON
Filed: 2017-05-26
Abstract: A method of pressure testing a casing system (12) comprising deploying an apparatus (110) with a container (68) formed from drill pipe or production tubing, on a string of drill pipe or production tubing into a well, such that a port (61) thereof is provided in an isolated section of the well. The isolated section of the well has a higher pressure than the pressure of a gas sealed in the container (68). The port (61) is opened and pressure in the isolated section is monitored to assess its integrity. Communication with the apparatus is achieved by wireless means sending pressure data, control signals for controlling the port and/or other data or commands.
Patent EA-037432-B1 (EA)
Title: Construction chain saw
Inventor: BOCHKAREV GENNADY VLADIMIROVICH
IPC: B23D57/02
Filed: 2018-11-20
Abstract: The invention relates to the field of construction and is intended for cutting stone materials such as blocks of porous concrete, foamed concrete, and aerated concrete. Technical result: simplified chain tensioning system by using the weight of the drive motor, improved chain lubrication, and machine maintenance. The chain saw 1 is made as mobile one and includes the unit 2 with the saw chain 3 on the guide rail 4 in the height-adjustable protective casing 5, the electric motor 6 mounted with the possibility of tensioning by the saw chain 3 under the action of its own weight. The unit 2 with the saw chain 3 is mounted on the housing 9 by means of the post 8 and is fitted with the control panel 18. On the housing 9 there is the working table 10 with the possibility of rectilinear movement along the guide rail 4 with the saw chain 3. The working table is fitted with the stop block 11 for basing the workpieces 12 to be cut, the angular device 13, and the removable chamfering device 14. The housing 9 of the chain saw 1 is mounted on two portal-shaped stands 15 in the form of trapezoid with support legs 16 fitted with wheels 17 for moving on the supporting surface 7. The control panel 18 contains the switch 20, the foot pedal 19, and a built-in device for disconnecting the electric motor 6 from a power source, as well as the tank 21 for oil with the dosing electric valve for the saw chain 3 lubrication.
Patent EA-036469-B1 (EA)
Title: Metal wire feeding system and corresponding method
Inventor: FORSETH TROND
IPC: B23K9/133
Filed: 2017-03-17
Abstract: Provided are a wire feeding system and a method for continuously providing a metal wire to a welding torch for manufacturing objects by solid freeform fabrication to provide continuous deposition of metal to the freeform object, especially objects made with titanium or titanium alloy wire. The system comprises a wire supply spool (50), a cabinet with an entry wire position detector (110), a wire feeding device (200), at least three slack wire guides (300, 400, 500), a slack wire pulling device (600) and a cabinet exit guide (1000).
Patent EA-036752-B1 (EA)
Title: Method for producing gel for rectal and topical administration comprising nifedipine and lidocaine hydrochloride (variants)
Inventor: IKSANOV RUSTAM MUNIROVICH
IPC: A61K31/4422
Filed: 2019-02-25
Abstract: The invention relates to pharmaceutics, including pharmaceutical compositions that form a base for gels, and to methods for producing gels which are intended principally for preventing and/or treating anal fissures, haemorrhoids and medical conditions associated therewith, and for reducing pain after a haemorrhoidectomy. In particular, the invention relates to formulations and preparation methods, and also to the use of gels comprising nifedipine and lidocaine. The technical result is achieved by the production of a gel formulation comprising nifedipine and lidocaine hydrochloride, each variant of which stabilizes the gel-like properties, provides transparency, maintains the stability of the properties for at least three years, and the use of which makes it possible to diminish the clinical symptoms of haemorrhoids to the point of completely eliminating said symptoms, to heal an anal fissure and to manage pain, including following a haemorrhoidectomy. All of the proposed inventions are industrially applicable; laboratory tests have shown that the subject matter presented can be realized in practice and has a wide range of applications in the pharmaceutical industry.
Patent EA-036641-B1 (EA)
Title: Power supply unit for aerosol inhaler
Inventor: AKAO TAKESHI
IPC: H02J7/00
Filed: 2020-01-16
Abstract: A power supply unit for an aerosol inhaler includes a power supply able to discharge power to a load for generating an aerosol from an aerosol source; a connector able to be electrically connected to an external power supply; and a charging device configured to convert power which is input from the connector into charging power for the power supply. The power supply unit further includes a first zener diode which is provided between the connector and the charging device so as to be connected in parallel with the charging device, and the first zener diode is connected so as to be closer to an input of the charging device than to an output of the connector.