baber/WOPTO huggingface dataset:
Patent DK-1017803-T3 (DK)
Inventor: HARRINGTON JOHN J
IPC: C12N15/67
Filed: 1998-09-25
Granted: 2010-08-23
Abstract: The present invention relates generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also relates generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. In another embodiment, the expression of the endogenous gene may be further increased by co-integration of one or more amplifiable markers, and selecting for increased copies of the one or more amplifiable markers located on the integrated vector. The invention also provides methods for the identification and expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention also provides methods for isolation of nucleic acid molecules (particularly cDNA molecules) encoding transmembrane proteins, and for isolation of cells expressing such transmembrane proteins which may be heterologous transmembrane proteins. The invention also relates to isolated genes, gene products, nucleic acid molecules, and compositions comprising such genes, gene products and nucleic acid molecules, that may be used in a variety of therapeutic and diagnostic applications. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes.
Patent DK-1032302-T3 (DK)
Inventor: WELLNHOFER ERNST
IPC: A61B5/0215
Filed: 1998-11-20
Granted: 2006-04-24
Abstract: The invention relates to a method for the correction of measured value falsifications in invasive pressure measurements with a fluid-filled system, in which the measured pressure is passed via the fluid-filled system to an external pressure transducer, which converts the pressure signal into an electrical signal. To provide a method and a device for invasive pressure measurement with fluid-filled systems which are improved with respect to the correction of measured value falsifications, are cost-effective and versatile in their use, the electrical signal is passed through an analog/digital converter and the digitized signal is fed to a signal analyzing and processing unit, which operates on the basis of a digital Fourier analysis. Furthermore, a heartbeat-related or segmental analysis is carried out and the signal is combined with empirically determined correction data on the basis of the analysis. The correction data are emitted as Fourier coefficients and the signal corrected by the signal analyzing and processing unit is passed to an output and/or evaluating unit.
Patent DK-0931741-T3 (DK)
Inventor: BENZ MARTIN
IPC: B65H31/34
Filed: 1999-01-20
Granted: 2003-07-14
Abstract: A paper stack turning machine (1) incorporates a jack by means of which the stack of sheets of paper is lifted, inclined and inverted. It further has clamps (4) which hold the stack of paper secure during this operation, pads with which the paper stack sides are re-aligned as required, and ventilators which loosen the sheets of paper from each other. One side of the stack (B) has a side-face rule (5) which operates in at right angles to the clamps (4), and which may be repositioned parallel to the direction of the clamp (4) plane.
Patent ES-2208158-T3 (ES)
Inventor: HAGER HARALD DR
IPC: B32B27/34
Filed: 2000-01-21
Granted: 2004-06-16
Abstract: The thermoplastic composite material comprises a polyamide layer bonded to a polyester layer by means of an adhesive (I) comprising a blend of polyamide prepared from stoichiometric amounts of a diamine containing 6-12C atoms and dicarboxylic acids, and a polyester prepared from a diol containing a mixture of dicarboxylic acids. Thermoplastic composite material comprises a polyamide layer bonded to a polyester layer by means of an adhesive (I) comprising at least 50 wt.% of a blend of: (a) 20-80 wt.% of a polyamide prepared from stoichiometric amounts of a diamine containing 6-12C atoms and dicarboxylic acids, including at least 5 mol% of dicarboxylic acids (II) containing 10-36 C atoms; and (b) 20-80 wt.% of a polyester prepared from a diol containing 2-12 C atoms and a mixture of 30-95 mol% of an aromatic dicarboxylic acid containing 6-20 C atoms and 5-70 mol% (II). Independent claims are also included for the following: (1) production of the composite material by multicomponent injection molding, coextrusion or coextrusion/blow molding; (2) an adhesive as defined for (I).
Patent ES-2259589-T3 (ES)
Title: Uso de acido ferulico para tratar hipertension.
Inventor: SUZUKI ATSUSHI
IPC: A61K9/00
Filed: 2000-09-22
Granted: 2006-10-16
Abstract: Uso de una composición que comprende: (a) al menos un compuesto de ácido ferúlico seleccionado del grupo constituido por ácido ferúlico, una sal de ácido ferúlico y un éster ferúlico, en el que el resto alcohólico del éster ferúlico se selecciona ente alcoholes alquílicos o alquenílicos lineales o ramificados que tienen de 1 a 40 átomos de carbono, alcoholes arílicos que tienen de 6 a 40 átomos de carbono, alcoholes terpénicos, esterol, esterol trimetílico y esterol vegetal, y (b) una composición diglicérica para preparar un medicamento destinado a tratar y/o prevenir la hipertensión, una enfermedad cardiaca o una enfermedad cerebrovascular.
Patent ES-2304340-T3 (ES)
Title: Anticuerpos dirigidos contra procalcitonina, su preparacion y uso.
Inventor: ALTHAUS HARALD
IPC: A61K39/395
Filed: 2000-11-25
Granted: 2008-10-16
Abstract: Anticuerpo que se une a un péptido que tiene la secuencia de aminoácidos Val-Gly-Ala-Pro-Gly-Lys-Lys- Arg-Asp-Met-Ser-Ser, caracterizado porque se une a la procalcitonina pero no se une a la calcitonina libre, a la catacalcina libre ni a la N-procalcitonina libre y porque es producido por la línea de células de hibridoma 98-31/04 (DSM ACC2437).
Patent ES-2203415-T3 (ES)
Inventor: KLAMPFER JOHANN
IPC: F24D3/10
Filed: 2000-04-07
Granted: 2004-04-16
Abstract: The distributor for fluids has several interconnected housings (1) for containing valves, flow-meter, thermal sensors especially. The housings have an axially continuous main duct (2) and at least one transverse duct (16) connected to the main duct. An axial extension (3) to the main duct is inserted to a wider part (4) of the main duct of the adjoining housing. The outer surface (6) the extension has at least one holder for a sealing ring. The extension has at least one radially projecting lug (7) which is part of a bayonet fastening (7,9) and which cooperates cavities (9) in the inner wall (8) of the wider part. The cavities have sections (10,11) running in an axial and peripheral direction.
Patent ES-2215611-T3 (ES)
Title: Dispositivo amortiguador.
Inventor: HAAB KARL
IPC: E05F5/00
Filed: 2000-03-14
Granted: 2004-10-16
Abstract: Dispositivo amortiguador con un cuerpo que puede montarse en un carril (4), un elemento de amortiguación para fines de suspensión elástica y un muelle de retención para retener un mecanismo de rodadura (6) guiado en el carril (4) y previsto para soportar y guiar elementos de hoja de puerta desplazables (2), caracterizado porque el cuerpo (11) del dispositivo amortiguador (10), dotado al menos aproximadamente de una forma de perfil en U, troquelado a partir de un elemento metálico y curvado, presenta una primera y una segunda aletas (14; 18) que están unidas una con otra por medio de una pieza central (20) que va unida o se puede unir con un muelle de retención (13) que sirve para retener el mecanismo de rodadura (6), y porque las piezas extremas (17, 19, 26; 17*, 19*) de las aletas (14; 18) están previstas para sujetar el elemento de amortiguación (12).
Patent ES-2215616-T3 (ES)
Title: Preparados liquidos y sistemas de agentes tensioactivos y disolventes.
Inventor: WUERTZ JOCHEN
IPC: C09K23/42
Filed: 2000-03-13
Granted: 2004-10-16
Abstract: Sistema de agentes tensioactivos y disolventes para formulaciones orgánicas líquidas, caracterizado porque contiene b1) uno o varios agentes tensioactivos sobre la base de compuestos aromáticos, y b2) uno o varios fosfatos y/o fosfonatos orgánicos totalmente esterificados, seleccionados entre el conjunto que consta de b2.1) ésteres de ácido fosfórico con alcoholes seleccionados entre el conjunto que consta de - alcanoles monovalentes con 5 a 22 átomos de C, - dioles o polioles, - alcoholes arílicos, alquilarílicos, poli(alquil)arílicos o poli(arilalquil)-arílicos, - alcoholes alcoxilados, que se obtienen por reacción de los alcoholes precedentemente mencionados con óxidos de alquileno, o - alcoholes alcoxilados, que se obtienen por reacción de alcoholes monovalentes con 1 a 4 átomos de C y óxidos de alquileno, y b2.2) fosfonatos sobre la base de ácidos alquil-, aril-, alquilaril-, poli(alquil)aril- o poli(arilalquil)-aril-fosfónicos, esterificados dos veces con alcoholes y/o con alcoholes alcoxilados, estando los alcoholes seleccionados entre el conjunto formado por - alcoholes monovalentes con 1 a 22 átomos de C, - dioles o polioles, - alcoholes arílicos, alquilarílicos, poli(alquil)arílicos y poli(arilalquil)arílicos o - alcoholes alcoxilados, que se obtienen por reacción de los alcoholes precedentemente mencionados con óxidos de alquileno, realizándose que los tres componentes alcohólicos del éster de ácido fosfórico (b2.1), o los dos componentes alcohólicos del fosfonato (b2.2), pueden ser iguales o diferentes, y están seleccionados de tal manera que el éster sea un disolvente polar, que a 20ºC es insoluble en agua, o es soluble en agua hasta en 5 g/l, y que en una solución acuosa no forma ningún agregado micelar.
Patent ES-2181648-T3 (ES)
Title: Dispositivo para cerrar envases fabricados de material termosellable.
Inventor: ROMIJN BAREND BASTIAAN
IPC: B29C65/18
Filed: 2000-02-02
Granted: 2003-03-01
Abstract: Dispositivo (10; 10a a 10e) para cerrar envases (1) fabricados de material termosellable, con dos mordazas de sellado (11, 12; 11a, 12a; 35, 38; 42, 43) para la formación de costuras transversales (3) en la región de superficies de sellado (18, 19; 18a, 19a; 18b) dispuestas paralelas entre sí en las superficies frontales (16, 17) de las mordazas de sellado (11, 12; 11a, 12a; 35, 38, 42; 43), donde al menos una superficie de sellado (18, 19; 18a, 19a; 18b, 19b) está configurada flexible para la compensación de diferentes espesores de material del envase (1) a lo largo de las costuras transversales (3) por medio de una escotadura (22; 31; 39) en forma de ranura en la mordaza de sellado (11, 12; 11a, 12a; 35, 38, 42; 43), caracterizado porque al menos una mordaza de sellado (11, 12; 11a, 12a; 35, 38, 42; 43) presenta dos superficies de sellado (18, 19; 18a, 19a; 18b, 19b) separadas una de la otra por una zona intermedia (21), que se extienden a lo largo de la costura transversal (3), y porque una de las dos superficies de sellado (19; 19a; 19b) presenta una distancia más reducida con respecto a la superficie de sellado opuesta (19; 19a; 36) que colabora con ella, que la otra superficie de sellado (18; 18a), de manera que cuando se mueven las dos mordazas de sellado (11, 12; 11a, 12a; 35, 38, 42; 43) una hacia la otra, se deforma elásticamente la superficie de sellado (19; 19a; 19b) que presenta una distancia reducida durante la formación de la costura transversal.
Patent ES-2209870-T3 (ES)
Title: Reactor de haces tubulares, especialmente para reacciones cataliticas en fase gaseosa.
Inventor: OLBERT GERHARD
IPC: B01J8/06
Filed: 2000-03-15
Granted: 2004-07-01
Abstract: Reactor de haces tubulares (13), que tiene un haz de tubos de reacción (18), que comprende numerosos tubos de reacción paralelos (17) colocados dentro de una camisa (15), teniendo dicho haz de tubos de reacción (18) desde 10.000 hasta 50.000 tubos de reacción (17), y tiene dispositivos para introducir y descargar un medio de transferencia de calor, que fluye alrededor de los tubos de reacción (17) presentando los tubos de reacción un diámetro externo da y una distribución de los tubos t, caracterizado porque la proporción t/da entre la distribución de los tubos t y el diámetro externo da de un tubo de reacción toma un valor, al menos, de 1, 3.
Patent ES-2385872-T3 (ES)
Inventor: RITTER GUENTER
IPC: C02F1/58
Filed: 2000-08-16
Granted: 2012-08-02
Abstract: A method is described for improving water quality or correcting and adjusting important chemical parameters of the water in biological tank systems, such as aquaria (warm, cold, fresh or salt water), garden ponds, carp pools, water gardens and large aquaria (zoos, public aquaria) whereby the following are added to the tank system individually or arbitrarily combined: a) for reduction of phosphate concentration, at least one highly or poorly soluble Al<3+>, Fe<3+>, TiO<2+>, ZrO<2+> or Ca<2+> salt of an organic carboxylic acid, optionally mixed with an organic carboxylic acid; b) for reduction of nitrate concentration or limiting nitrate increase, at least one water soluble N-free biologically degradable organic compound; c) for an increase in carbonate hardness or the HCO3<-> concentration, at least one alkali or earth alkali metal salt of an organic carboxylic acid; d) for an increase in total hardness or the concentration of Ca<2+> and Mg<2+> hydrogen carbonates, a mixture of at least one Ca<2+> and Mg<2+> salt of organic carboxylic acids and e) for an increase in CO2 concentration at least one biologically degradable compound and an appropriate single- or multi-component product.
Patent ES-2282155-T3 (ES)
Inventor: PFRENGLE ANDREAS
IPC: C07C69/88
Filed: 2000-12-23
Granted: 2007-10-16
Abstract: There is provided a single-step process for the preparation of a compound of formula (I). Compounds of formula (I) are useful as starting materials in the synthesis of natural products and in the manufacture of benzo-phenone fungicidal agents.
Patent ES-2221874-T3 (ES)
Inventor: FALCIANI MARCO
IPC: A61K9/50
Filed: 2001-04-27
Granted: 2005-01-16
Abstract: Use of microparticles of Paclitaxel stabilized with albumin for preparing a drug for the treatment of solid tumors sensitive to Paclitaxel, and the drug obtained thereby.
Patent ES-2231347-T3 (ES)
Inventor: ARUGA KOTOYA
IPC: G07D9/00
Filed: 2001-06-19
Granted: 2005-05-16
Abstract: A printer unit has a base frame (24) and a moving frame (26) supported thereon for rotation relative thereto so that the upper part of the moving frame can be inclined to the front of an installation-type transaction device. The moving frame (26) is provided with a bearing member (40) that supports a shaft of rolled paper, a print mechanism section (46), an edge of paper insertion slot (44) for introducing the rolled-paper end into the print section, and an edge of paper discharge port (50a). The bearing member (40) has a rolled-paper-shaft acceptance port (40b) that is opened to the rear of the moving frame, and the edge of paper insertion slot (44) is oriented to the rear of the moving frame. At maintenance and inspection time, the moving frame (26) is inclined forward, whereby the shaft acceptance port (40b) and the edge of paper insertion slot (44) are oriented to the worker. <IMAGE>
Patent ES-2275633-T3 (ES)
Inventor: SOKOL LEOPOLD
IPC: E04B5/40
Filed: 2001-03-27
Granted: 2007-06-16
Abstract: The formwork component (1) for making the metal pan (4) has a section composed off a succession of omega shapes (7). These shapes have a top (8) on either side of which extend two inclined web plates (9) and two sole plates (10). On the web plates are beads (12) located on the diagonal (13) of a rectangle representing a design. The beads define a number of designs forming inclined notching.  An Independent claim is also included for the pan joist concrete floor.
Patent ES-2269337-T3 (ES)
Inventor: RUGGIERI ALBERTO
IPC: B23Q3/157
Filed: 2001-05-18
Granted: 2007-04-01
Abstract: The tool-holder storage device (1) includes a rotating unit (15) equipped with a multitude of supports (17) for said tools (U). The rotating unit has a development with an edge composed by an incomplete arc of a circumference along which the supports for the tools are distributed.
Patent ES-2312417-T3 (ES)
Inventor: VERBERKT MARK H
IPC: H04N7/24
Filed: 2001-02-09
Granted: 2009-03-01
Abstract: A transmitter ( 10 ) for transmitting a multiplex signal ( 20 ) containing a number of tables with information about the signal ( 11 ) to a receiver ( 12 ), capable of selecting some or all of these tables ( 26 ) from the signal ( 20 ) and storing them on a table storage medium ( 22 ). The stored tables ( 27 ) are transmitted for example when the receiver ( 12 ) requests them, or when the information therein is updated. By storing these tables in the transmitter ( 10 ), the problem that the receiver has to wait for them to occur in the multiplex signal ( 10 ) is overcome.
Patent ES-2307607-T3 (ES)
Inventor: POULTON ADRIAN ROGER
IPC: F16L33/28
Filed: 2001-04-17
Granted: 2008-12-01
Abstract: A connection device for fitting to a member, particularly to a corrugated flexible pipe (146:246:446) formed with a series of spaced annular grooves, the device comprising first and second tubular bodies (10, 11) coupled together, in use, with the pipe received in an open end of the first body (10). The first body has a plurality of resilient lugs (14) with respective inwardly directed projections (17) at the ends thereof to be received in one of the said grooves to grip the pipe. The two bodies can be relatively angularly moved between a neutral position of the device, where the pipe is retained by the resilience alone of the lugs, an unlocked position, where the lugs are released from the pipe, and a locked position, where the lugs are forced into locking engagement with the pipe, movement of the lugs being controlled by cam formations (29) extending from the end surface of the second body (11). In other embodiments the bodies can have a rotation lock in said locked position and/or neutral position, and/or a lock to prevent outward movement of the lugs when the bodies are in the locked position. <IMAGE>
Patent ES-2232635-T3 (ES)
Inventor: AROCENA YARZA MIGUEL ANGEL
IPC: B63B17/06
Filed: 2001-06-26
Granted: 2005-06-01
Abstract: The system is meant to detect and record in real time any irregular dumping occurring during the operation of any ship, both of waste hydrocarbons stored in the bilge (1) of the ship and of residues from cleaning the crude oil tanks of oil tankers. The system is based on providing two level probes (13-14) to detect the upper level of the layer of waste hydrocarbons (3) and its bottom layer, which floats on a volume of waste water (2) contained in the bilge (1), as well as optionally a third probe (16) may be provided in a tank (10) for storage of waste hydrocarbons separated from the waste water, so that the data obtained from these probes are recorded and stored by a multiparameter recording station (15) which, in combination with a computer system of the port allows to know the variation in volume of waste hydrocarbons during the operation of any ship. Oil tankers are provided with a flow meter (18) in the pipe (19), which detects the data corresponding to residues obtained from cleaning the tanks (17) (see Figure 2), with the data obtained by this flow meter being sent to the same recording station (15) in order to know the variations in volume of these residues. <IMAGE>
Patent ES-2267802-T3 (ES)
Title: Lubricante de aceite blanco para extrusion.
Inventor: COHEN STEPHEN CEDRIC
IPC: E03B7/00
Filed: 2001-07-30
Granted: 2007-03-16
Abstract: Una composición de poli(cloruro de vinilo) que comprende: (a) una resina de poli(cloruro de vinilo) (PVC); y (b) un aceite blanco de calidad farmacéutica que tiene una viscosidad de al menos 100 mm2s-1 a 40ºC.
Patent ES-2267817-T3 (ES)
Inventor: OVERBEEK GERARDUS CORNELIS
IPC: C08F265/04
Filed: 2001-10-01
Granted: 2007-03-16
Abstract: An aqueous dispersion comprising an alkyd, vinyl polymer I, vinyl polymer II and a liquid medium where vinyl polymer I is preformed prior to incorporation into the aqueous dispersion and where vinyl polymer II is prepared in the presence of the alkyd and the vinyl polymer I.
Patent ES-2263671-T3 (ES)
Inventor: PETERSSON BO
IPC: G01N33/58
Filed: 2001-10-12
Granted: 2006-12-16
Abstract: An assay implantation apparatus is provided comprising a sensor for use for the in vivo measurement of an analyte and means for implanting said sensor within an upper layer of the skin from which it is naturally ejected over time by growth of the skin and progressive replacement of the outer layer of the skin.The sensor may comprise microparticles containing a chemical assay system into which an analyte may diffuse from intercellular fluid and which assay system can be interrogated remotely by a light signal and a fluorescence sensor.
Patent ES-2271090-T3 (ES)
Inventor: BURTON GERARDO
IPC: C07J71/00
Filed: 2001-09-17
Granted: 2007-04-16
Abstract: A method of preparing 21-hydroxy-6,19-oxidoprogesterone, or an acylated or phosphorlated version thereof.
Patent ES-2496101-T3 (ES)
Title: Adaptador para conjunto de alimentación
Inventor: BECK KENT F
IPC: F04C5/00
Filed: 2001-12-11
Granted: 2014-09-18
Abstract: Un sistema de administración de soluciones para su disposición en una bomba de infusión, que comprende un adaptador (100) para conjunto de alimentación, y que además comprende una línea (314) de entrada de un conjunto de infusión, una parte (200) central de acoplamiento de la bomba de un conjunto de infusión y una línea (318) de salida de un conjunto de infusión unida al adaptador (100) para conjunto de alimentación, caracterizado por que el adaptador (100) para conjunto de alimentación comprende: un primer conector (108) y un segundo conector (112) conformados de forma integral entre sí (reivindicación original 87), estando el primer conector (108) unido a la línea de entrada de un conjunto (200) de infusión y la parte (200) central de acoplamiento de la bomba de un conjunto de infusión; estando el segundo conector unido a la línea de salida de un conjunto (200) de infusión y la parte (200) central de acoplamiento de la bomba de un conjunto de infusión y un mecanismo (300) contra el flujo libre dispuesto en comunicación con el uno del primer conector (108) y el segundo conector (112) y dispuesto en uno de la línea (314) de entrada, parte (200) de acoplamiento de la bomba y línea (318) de salida.
Patent ES-2337768-T3 (ES)
Inventor: CANNON-CARLSON SUSAN V
IPC: C07K14/47
Filed: 2001-11-28
Granted: 2010-04-29
Abstract: Methods for purifying adenoviruses from a contaminated sample using a hydroxyapatite medium are provided. Sodium chloride concentrations present in buffers used throughout the method are at least 150 mM to prevent the adenovirus from irreversibly binding to the hydroxyapatite. Levels of contaminants and empty adenovirus capsids from samples purified by conventional purification techniques are further reduced to provide a highly pure adenovirus preparation.
Patent ES-2284740-T3 (ES)
Inventor: YOUNG JAMES W
IPC: A61K31/60
Filed: 1993-08-03
Granted: 2007-11-16
Abstract: Use of a composition comprising a compound of formula I:   
or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.