Patent AU-2013202137-B2 (AU)
Title: Peptide agents for cancer therapy
Inventor: AGREE MICHAEL VALENTINE
IPC: A61K38/17
Filed: 2013-01-24
Granted: 2015-09-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/110120 A1 1 August 2013 (01.08.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 7/06 (2006.01) A61K38/10 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 7/08 (2006.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K38/08 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/AU2013/000045 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 24 January 2013 (24.01.2013) NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (25) Filing Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (26) Publication Language: English ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 2012900259 24 January 2012 (24.01.2012) AU kind of regional protection available): ARIPO (BW, GH, 2012904368 6 October 2012 (06.10.2012) AU GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicant: INTER-K PTY LIMITED [AU/AU]; c/- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PricewaterhouseCoopers, Level 6, 26 Honeysuckle Drive, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Newcastle, New South Wales 2300 (AU). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventor: AGREZ, Michael Valentine; 46 Sherbum TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Place, Charlestown, New South Wales 2290 (AU). ML, MR, NE, SN, TD, TG). (74) Agent: ADAMS PLUCK; Suite 4, Level 3, 20 George St, Published: Hornsby, New South Wales 2077 (AU). - with international search report (Art. 21(3)) (54) Title: PEPTIDE AGENTS FOR CANCER THERAPY 3 _-RAKAKAAAAR -ORSKSSSSSR ) 2 - RGKGKGGGGR 0,0 11~ .10 1.00 11.1 000 (57) Abstract: There is provided peptides for inhibiting growth of cancer cells, the peptides comprising the amino acid sequence RxKxKxxxxR wherein K and R are respectively lysine and arginine amino acid residues, each x is independently an amino acid, and5 wherein the peptide has 50% or less amino acid sequence identity with the amino acid sequence RSKAKNPLYR (SEQ ID. No. f4 2). Each x amino acid may independently be an amino acid residue selected from the group consisiting of alanine (A), valine (V), leucine (L), isoleucine (I), threonine (T) and seine (S) amino acid residues. There is also provided chimeric proteins incorporating a peptide of the amino acid sequence 10 RxKxKxxxxR, nucleic acids encoding for the peptide, expression vectors including a nucleic acid encoding the peptide for expression of the peptide, and methods for use of the peptide for inhibiting growth of cancer cells.