baber/WOPTO huggingface dataset:
Patent PT-1820494-E (PT)
Title: Microparticles consisting of estradiol and cholesterol
Inventor: SAVOIR JOHN CLAUDE
IPC: A61K9/26
Filed: 2004-06-10
Abstract: The invention provides a method for effecting simultaneous contraception and hormone replacement therapy in a female mammal comprising administering to said mammal a pharmaceutical formulation comprising particles of 17-²-estradiol and cholesterol in about a 1:1 molar ratio, and particles of progesterone; wherein the weight ratio of 17-²-estradiol to progesterone is about 1:40.
Patent PT-1997510-E (PT)
Title: Non-neurotoxic plasminogen-activating factors for treating strokes
Inventor: SCHLEUNING WOLF-DIETER
IPC: A61P7/02
Filed: 2002-10-31
Abstract: Use of a plasminogen activating factor (A) for treatment of stroke, where the activity of (A) is increased by more than 650 fold in presence of fibrin, is new. Independent claims are also included for the following: (1) tissue plasminogen activator (tPA) having an autolysis loop that includes His420, Asn421, Ala422 and Cys423; (2) urokinase having an autolysis loop that includes Val420, Thr421, Asp422 and Ser423; and (3) pharmaceutical composition containing (A) and at least one other medically active agent, or their salts. ACTIVITY : Cerebroprotective. No biological data is given. MECHANISM OF ACTION : None given.
Patent PT-2189586-E (PT)
Title: Panel element with reinforcement
Inventor: MICHAEL STUECKLIN
IPC: E04B5/02
Filed: 2008-11-19
Abstract: The plate element (10) has laterally adjacent fields (51) of a grid-shaped structure (50), where the fields form an elongated support strip (60). Individual support areas (30) are connected with each other, and are reinforced. The support strip has a solid area (70), where the laterally adjacent fields form an elongated carrier strip (80) with hollow body areas (20). An independent claim is included for a method for manufacturing a plate element, particularly concrete plate element.
Patent PT-2406253-E (PT)
Title: Benzofuranyl derivatives used as glucokinase inhibitors
Inventor: LING ANTHONY LAI
IPC: A61K31/497
Filed: 2010-03-04
Abstract: The present invention provides compounds of formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glukokinase.
Patent PT-651765-E (PT)
Inventor: NESTOR JOHN J JR
IPC: C12N1/21
Filed: 1993-07-13
Abstract: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic  alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:     Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
Patent PT-670736-E (PT)
Inventor: KUNKEL STEVEN L
IPC: A61K51/08
Filed: 1993-10-04
Abstract: A method of imaging a target site in an animal's body in which a labelled CXC chemokine is introduced into the animal's body and allowed to accumulate at a target site which includes Interleukin-8 receptor molecules. The accumulated, labelled CXC chemokine is then detected so as to image the target site of the body.
Patent PT-657545-E (PT)
Inventor: KAWAHARA SUMI
IPC: C12Q1/28
Filed: 1994-12-06
Abstract: An assay method for biological components in which hydrogen peroxide generated from an enzymatic reaction is detected with peroxidase and a color developer capable of being oxidized in the presence of an amphoteric surfactant and a ferrocyanide. Even when the biological component to be detected is present in a very small amount, the interference of bilirubin can be eliminated in assays of biological components in which peroxidase generated from an enzymatic reaction is detected using peroxidase and a color developer capable of being oxidized.
Patent PT-748193-E (PT)
Inventor: FISHER JOHN
IPC: A61F2/32
Filed: 1995-02-27
Abstract: A prosthetic joint is described consisting of an acetabular cup (10) and a femoral component having a spherical head (12) of radius R1. The surface (14) of the socket in the acetabular cup (10) is defined by an "alpharabola". The alpharabola geometry is described by:  alpha x<2> + y<2> + z<2> = 2R2x, 0 <  alpha  < 1, where R2 is the desired minimum radius of curvature; x is a Cartesian coordinate representing distance from the point of minimum radius of curvature (30) along the normal to the surface at that point; and y and z are the remaining Cartesian coordinates. The alpharabola surfaces are surfaces of revolution about the x axis. When R2 is less than R1, a pool of fluid (22) is trapped at the pole of the apharabola and there is an annular contact ring (24) between the two surfaces (14, 16) which serves to trap the fluid. When R1 is equal to R2, in place of an annular contact ring (24), there is an enlarged contact area (26). Both arrangements contribute to more effective squeeze film lubrication and less wear on the two components (10, 12).
Patent PT-792110-E (PT)
Inventor: HUGHES IAIN ALLAN
IPC: A61K47/34
Filed: 1995-12-13
Abstract: A flavor, perfume, coolant or antimicrobial composition comprising a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having formula (I), wherein: X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from about 0 to about 200, m is from about 1 to about 40, q is from about 1 to about 100, the molecular weight of the residue (C2H4O-)x(C3H6O-)yX is from about 50 to about 2000, and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100. The compositions provide improved surface residuality, impact and/or antimicrobial efficacy.
Patent PT-767007-E (PT)
Inventor: CONTAXIS WILLIAM III
IPC: B05B11/00
Filed: 1996-10-02
Abstract: A pump dispenser has a body (12) defined by a top wall and a front end and a nozzle cap (22) rotatably mounted on the body (12). The cap (22), which must be rotated for the nozzle (10) to operate, has an opening in a side wall thereof adjacent the front end. An elongate blocking tab (30) has a rear portion unitary with and connected to said top wall, and a middle portion extends forwardly from the rear portion and is disposed in the opening in the nozzle cap. The tab (30) also has a forward finger-grippable portion extending forward from said middle portion. The middle portion, by being in the opening, prevents rotary movement of the nozzle cap (22) until the blocking tab (30) is torn from the top wall (14). <IMAGE>
Patent PT-956269-E (PT)
Inventor: MYRHAUG TERJE JOHAN
IPC: C02F1/40
Filed: 1996-07-04
Abstract: A separator for oils and fat for use in businesses, such as restaurants, large-scale catering establishments, canteens, kiosks, slaughterhouses, the food industry, the margarine and cooking oil industry, etc. together with the private household. The separation is performed via a surge chamber (B3) for low viscosity oils and fat, while heavier and more comminuted oil and fat particles are forced to undergo a longer separation route in the sedimentation chamber (B4) via horizontal oblique baffle plates (B5) and with an integrated sludge trap which is automatically discharged by means of a time-controlled valve (B16). The separator's water level is kept approximately constant by means of a time-controlled supply water valve (B17). The separated oil/fat volume is kept liquid until it is drained via a fat overflow (B10) and passed to a collecting tank (B12) with a level indicator (B13).
Patent PT-868355-E (PT)
Inventor: PETER WOLFGANG
IPC: B65D1/40
Filed: 1996-12-04
Abstract: The invention concerns a tin for foodstuffs, the tin comprising a base (10) and a peripheral wall (20) which projects from the base and surrounds an inner space (30). The upper edge of the wall delimits all around an opening (31) in the inner space (30), the inner space (30) widening conically upwards and the wall (20), which surrounds this inner space, merging at the bottom into the base (10) at a rounded portion (21). The merging region is designed such that a peripheral annular bearing line (11) is produced but, on the interior, the base is first further extended upwards and then a bearing surface (16) between 1.5 and 10 mm wide is produced by a downwardly projecting peripheral annular bead (15).
Patent PT-916651-E (PT)
Inventor: FUJITA TAKASHI
IPC: C07C317/32
Filed: 1997-04-01
Abstract: Phenylalkylcarboxylic acid derivatives of the general formula: <CHEM> wherein R<1> represents an alkyl group and the like, R<2> represents an alkylene group, R<3> represents a hydrogen atom and the like, X represents a substituted or unsubstituted aryl group and the like, Y represents an oxygen atom and the like, Z represents an alkylene group and the like, and W represents an alkyl group and the like), the pharmacologically acceptable salts thereof or the pharmacologically acceptable esters thereof are useful as therapeutic or preventive agents for hyperglycemia and the like.
Patent PT-998460-E (PT)
Inventor: HATZELMANN ARMIN
IPC: A61P25/28
Filed: 1998-07-18
Abstract: Compounds of formula I,in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are efficacious bronchial therapeutics.
Patent PT-1025444-E (PT)
Inventor: ALFRED LASKEY RONALD
IPC: C07K/
Filed: 1998-10-21
Abstract: Methods tor determining cell growth abnormalities, particularly cancerous or pre-cancerous cells, are described in which polypeptides involved in the preinitiation complex of DNA replication are detected. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Typically antibodies detecting these proteins are used in screening assays on tissue sections or smears. The detection of RNA encoding these proteins is also described. The application is particularly concerned with cervical neoplasia's but also describes screening for growth abnormalities of breast, colon, lung, bladder, skin, larynx, oesophagus, bronchus, lymph nodes and urinary tract tissue.
Patent PT-1029075-E (PT)
Inventor: BORGFORD THOR JON
IPC: G01N33/66
Filed: 1998-11-02
Abstract: A method is described for the rapid, sensitive and accurate determination of sucrose in biological fluids. A substrate is pre-coated with a glucose or fructose polymer and a transglycosidase enzyme. When the coated substrate is incubated with biological fluids containing concentrations of sucrose, the transglycosidase enzyme transfers monomers of glucose or fructose from the sucrose to the glucose or fructose polymer. The dimensions of the polymer are increased in proportion to the sucrose concentration of the samples. Newly formed polymer is subsequently quantitated in an immunoassay which employs either a combination of a carbohydrate-binding protein (which may be an antibody) and a conjugate of a secondary antibody and a marker enzyme, or a conjugate of a carbohydrate-binding protein and a marker enzyme. The assay is accurate at sucrose concentrations below 1  mu g/mL. No interference was observed at glucose concentrations as high as 25 mM. The sucrose detection assay is particularly useful in a non-invasive diagnostic test for gastric damage.
Patent PT-1062104-E (PT)
Inventor: CHATWIN CHARLES EDWARD
IPC: B42D15/10
Filed: 1999-03-03
Abstract: A method of manufacturing a security item comprises coextruding at least two polymer plastic materials (6,7) with different characteristics so as to form a substrate so that neither material are biaxially oriented, and providing security indicia (14) on the substrate.
Patent PT-1135065-E (PT)
Title: Biopsy needle and surgical instrument
Inventor: TERWILLIGER RICHARD
IPC: A61B17/34
Filed: 1999-07-13
Abstract: The present invention includes a biopsy needle for use in a biopsy gun or as surgical instrument, capable of taking multiple samples, and a guiding needle holder for holding a biopsy needle. The biopsy needle includes an inner needle, also called a stylet, and an outer needle, also called a cannula, and a guiding needle holder. The stylet has a recess in the vicinity of its distal end which receives the tissue sample. The guiding needle holder includes an integrated spacer, and first and second connecting elements. The first connecting element holds the proximal end of the cannula and is displaceably attached along the length of the integrated spacer. The second connecting element holds the proximal end of the stylet and is fixedly attached to the distal end of the integrated spacer. The connecting elements each have an opening that facilitates insertion of the biopsy needle into a known biopsy gun in either the cocked or uncocked position. In an alternate embodiment, the guiding needle holder includes an integrated spacer that fixedly holds the stylet, and a connecting element that displaceably holds the cannula.
Patent SG-37689-G (SG)
Title: Connecting lock
IPC: F16B7/04
Filed: 1989-06-15
Abstract: PCT No. PCT/EP85/00108 Sec. 371 Date Apr. 15, 1987 Sec. 102(e) Date Apr. 15, 1987 PCT Filed Mar. 16, 1985 PCT Pub. No. WO85/04220 PCT Pub. Date Sep. 26, 1985.A connecting element for the releasable connection of two structural parts of a stand, in particular a support section and a frame section, includes a housing and at least one locking element. An eccentric is rotatably supported in the housing locking element is guided longitudinally in the housing and has a clamping portion protruding from the housing to be introduced in an undercut groove of the support section and clamped therein. An eccentric head (76) of the may be locked in a bore hole of the frame section. The clamping portion of the locking element may be rotated within a limited angular range. The locking element is connected displaceably by a pulling element with the eccentric the clamping portion is a transverse bar.
Patent SG-64888-G (SG)
Title: System for the transmission of digital information signals
IPC: G06F11/10
Filed: 1988-09-29
Abstract: 1. System for the transmission of digital information signals, especially for digital sound transmission by satellites, having an encoder at the sending side and a decoder at the receiving side, in which the information signals to be transmitted are combined with a generator polynomial at the sending side in such a way that check places are associated with the information signals to be transmitted which are established from an arithmetical combination of the information signal with the generator polynomial, characterized in that a primitive BCH - code is used having the block length of 63 bits an 18 check places, of which the generator polynomial x**18 + x**17 + x**16 + x**15 + x**9 + x**7 + x**6 + x**3 + x**2 + x**1 + 1 is multiplicatively combined with the further generator polynomial x + 1, so that a generator polynomial for the encoder x**19 + x**15 + x**10 + x**9 + x**8 + x**6 + x**4 + 1 arises having a block length of 63 bits and 19 check places, so that at the receiving side as a result of the use of different decoding strategies there is carried out the correction of three errors and the recognition of four errors or the correction of two errors and the recognition of five errors or the correction of one error and the recognition of six errors or the recognition of seven errors, whereby the error recognition is used for the initiation of an error concealment measure.
Patent IE-780014-L (IE)
Title: Method for producing cements.
IPC: C04B7/26
Filed: 1978-01-03
Abstract: A process is disclosed for making a blistered, crystallizable glass material in a rotary kiln with simultaneous utilization of mineral-containing waste products, particularly fly ash, slag, and ashes from power works and refuse disposal plants, and sludge from water-purification plants.
[US4191546A]
Patent IE-36078-L (IE)
Title: Wall construction
IPC: F16B5/02
Filed: 1971-05-11
Abstract: 1349378 Self-tapping screws AMERICAN METAL CLIMAX Inc 7 May 1971 [1 June 1970] 13772/71 Heading B3N [Also in Division E1] Self-tapping screws 65, for use in interconnecting horizontal and vertical frame members of, e.g. glazed walls, each have a threaded shank 66 with thread sections removed along two opposed sides to provide flattened sides 68. The shank co-operates with a channel 55 formed inside a hollow aluminium member 50, the opposed flanges 57 and 58 of the channel having opposed arcuate grooves 61 formed therealong. The screw is inserted into the end of member 50 to a required depth and then turned through a quarter turn to the position illustrated in Fig. 13 (not shown). The head of the screw is shaped as shown to sit with its inner shoulder 70 on the rim of a hole in one face of a hollow vertical frame member.
[GB1349378A]
Patent IE-820676-L (IE)
Title: Pharmaceutical preparation
IPC: A61P9/08
Filed: 1982-03-23
Abstract: The present invention relates to a pharmaceutical preparation containing as the vasodilator N''-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and as the diuretic active component a compound selected from the group consisting of the thiazide or thiazide-like type diuretics and loop diuretics. The combination is valuable in the treatment of mammals, including man, suffering e.g. from hypertension or congestive heart failure.
[US4409222A]
Patent IE-40904-L (IE)
Title: Continuous colouration of aromatic polyester/cellulose¹unions
IPC: C09B69/00
Filed: 1975-04-03
Abstract: 1456586 Continuous dyeing of polyestercellulose blends IMPERIAL CHEMICAL INDUSTRIES Ltd 25 March 1975 [3 April 1974] 14783/74 Heading D1B Blends of aromatic polyesters and cellulosic materials are continuously dyed by applying to the union a reactive dye and a disperse dye containing at least 2 carboxylic acid ester groups, the dyes being fixed on the material which is thereafter subjected to a treatment in an aqueous alkaline bath at a pH above 8 and at a temperature between 50‹ and 85‹C. The dyes may be applied together or in any order, preferably the material is continuously padded or printed with a padding liquor or print paste containing the disperse dye, the reactive dye and alkaline agent, dried, heat treated and then given the aqueous alkaline treatment.
[GB1456586A]
Patent IE-36403-L (IE)
Title: Composite fabric
IPC: D06N3/00
Filed: 1972-06-06
Abstract: 1339518 Laminates ROSSENDALE COMBINING CO Ltd 6 June 1972 [17 June 1971] 28361/71 Heading B5N A composite fabric comprises a layer of textile material bonded to one side of a layer of polyurethane foam, the other side of the foam layer being bonded to one side of a layer of polyurethane film material which is impermeable to water, the other side of the film layer being bonded to a second layer of polyurethane foam. A further layer of textile material may be bonded to the exposed surface of the second polyurethane foam layer. At least one of the textile layers may comprise a knitted fabric or other non-woven material, e.g. a stitch-bonded web of viscose rayon, polyacrylonitrile or polyester fibres. The polyurethane foam layers which may be of the polyester type, may be 1À75 mm. thick. The polyurethane film which may have a thickness of 0À001-0À003 inch may be a strong, elastic, pliable film resistant to dry-cleaning solvents. The film and textile materials may be bonded to the foam layers by flame bonding or by means of an adhesive, e.g. an isocyanate-based, polyurethane prepolymer, urethane-urea, crosslinkable acrylic, rubber/resin or hot-melt adhesive. In Examples: (a) a melton cloth of wool and cotton fibres or a double jersey-polyester fabric and a polyurethane film are simultaneously bonded, one on each side of a polyurethane foam layer by flame bonding, the other surface of the film then being flamebonded to another layer of polyurethane foam which is simultaneously flame-bonded on its other surface to a nylon tricot fabric or (b) two laminates are prepared by flame-bonding one being a knitted nylon fabric bonded to a layer of polyurethane foam, the other side of which is bonded to a polyurethane film, and the other being a layer of polyurethane foam bonded to a knitted nylon fabric, and the two laminates then bonded together using a polyurethane, isocyanate or reactive acrylic copolymer/ melamine-formaldehyde resin adhesive.
[GB1339518A]
Patent IE-820875-L (IE)
Title: Bleaching activator granules.
IPC: C11D3/395
Filed: 1982-04-14
Abstract: 1. Claims for the Contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Bleaching activator in granular form comprising tetraacetylethylenediamine and a coating agent comprising at least one alkali metal polyphosphate and an alkali metal derivative of cellulose, characterised in that it is composed of : - 55 to 90% by weight of tetraacetylethylenediamine and - 10 to 45% by weight of coating agent. 1. Claims for the Contracting State : AT Process for washing articles based on natural, synthetic or artificial fibres, characterised in that there is used a bleaching activator in granular form, comprising tetraacetylethylenediamine and a coating agent comprising at least one alkali metal polyphosphate and an alkali metal derivative of cellulose, and composed of : - 55 to 90% by weight of tetraacetylethylenediamine and - 10 to 45% by weight of coating agent.
Patent IE-32343-L (IE)
Title: Powder composition
IPC: A61K9/00
Filed: 1968-07-25
Abstract: 1,242,211. Powder compositions for inhalation. FISONS PHARMACEUTICALS Ltd. 23 July, 1968 [8 Aug., 1967], No. 36270/67. Heading A5B. A pharmaceutical powder composition for inhalation comprises a mixture of a solid finely divided medicament having an effective particle size in the range 0.01 to 10 microns and a solid pharmaceutically acceptable water-soluble carrier having an effective particle size in the range 30-80 microns. The composition is preferably substantially free of particles having effective particle sizes in the range 11-29 microns. The medicament may be diluted with a solid pharmaceutically acceptable watersoluble diluent of the same effective particle size. The diluent or carrier may be dextran, mannitol or lactose preferably crystalline lactose. The medicament may be an antianaphylactic agent such as sodium chromoglycate, a sympathomimetic amine such as isoprenaline or ephedrine, an antibiotic such as penicillin or tetracycline, a steroid, enzyme, vitamin, antihistamine or mucolytic such as N- acetyl cysteine. A preferred composition contains sodium chromoglycate and isoprenaline sulphate. The surface characteristics of the medicament or carrier particles may have been modified by crystallisations, spray drying, precipitation or by coating with a pharmaceutically acceptable material, e.g. stearic acid or polyvinyl pyrrolidone (which coating may give the medicament sustained release action). The powder may be contained in a capsule, e.g. of gelatin or plastic, which is pierced for administration. The powder may be administered as a dispersion in an air stream obtained by simultaneous rotation and vibration of the pierced capsule. The composiitons are prepared by mixing together, preferably in a stirred mixer, the medicament and carrier, which if necessary have been subjected to comminution and particle size classification prior to mixing.
[GB1242211A]