baber/WOPTO huggingface dataset:
Patent EA-001037-B1 (EA)
Title: Method for diagnosing schizophrenia, set of two primers for realizing the method and kit comprising the set of primers
Inventor: LAURENT CLAUDINE
IPC: C12Q1/6883
Filed: 1996-04-29
Abstract: 1. A method for diagnosing schizophrenia, characterized in that said method being based on the detection in vitro of the presence of the allele Ep of the microsatellite DNA HUMTHO1 in the gene TH. 2. The method of claim 2, characterized in that the detection of the by allele Ep is realized by sequenation of DNA and/or by separation of DNA fragments in gel and/or by separation of DNA fragments in gel in non-denaturing conditions. 3. The method of claim 2, characterized in that the allele Ep is detected by separation of DNA fragments in gel. 4. The method of any claim 1-3, characterized in that using DNA extracted from mononuclear cells. 5. The method of any claim 1-4, characterized in that prior to detection of the allele Ep DNA is amplified. 6. The method of claim 5, characterized in that DNA is amplified, comprising the first intron of the TH full length or part of said intron. 7. The method of claim 6, characterized in that DNA is amplified which is a fragment of less than 300 pb, comprising microsatellite HUMTHO1 and flanking sequences. 8. The method of claim 6, characterized in that DNA is amplified which is a fragment of less than 200 pb, preferably less 160 pb. 9. A set of two primers for realizing the method of claim 8, having the following structure (pair A): 5' GGC AAA TAG GGG GCA AAA 3' (sense sequence) 5' TTA TCC AGC CTG GCC CAC 3' (anti-sense sequence) 10. A set of two primers for realizing the method of claim 8, having the following structure (pair B): 5' GGC AAA TAG GGG GCA AAA 3' (sense sequence) 5' GGC TTC CGA GTG CAG GTC 3' ( anti-sense sequence) 11. A set of two primers for realizing the method of claim 8, having the following structure (pair C): 5' GTT CCT CCC TTA TTT CCC 3' (sense sequence) 5' AGG GAA CAC AGA CTC CAT (anti-sense sequence) 12. A kit for detecting of the allele Ep of the microsatellite DNA HUMTHO1, comprising a set of primers of any claim 9-11. 13. A kit of claim 12 for diagnosing schzophrenia.
Patent EA-009860-B1 (EA)
Title: Piperazinyl and diazapanyl benzamides and benzthioamides
Inventor: APODACA RICHARD L
IPC: C07D295/18
Filed: 2003-10-21
Abstract: Substituted piperazinyl and diazapanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
Patent EA-009110-B1 (EA)
Title: Additive for increasing the density of a fluid for casing annulus pressure control
Inventor: BRADBURY ANDREW J
IPC: C09K3/00
Filed: 2003-10-14
Abstract: A method of controlling the pressure of a casing annulus in a subterranean well that includes injecting into the casing annulus a composition including a base fluid and a polymer coated colloidal solid material. The polymer coated colloidal solid material includes: a solid particle having an weight average particle diameter (d) of less than two microns, and a polymeric dispersing agent coated onto the surface of the solid particle during the cominution (i.e. grinding) process utilized to make the colloidal particles. The polymeric dispersing agent to may be a water soluble polymer having a molecular weight of at least 2000 Daltons. The solid particulate material may be selected from materials having of specific gravity of at least 2.68 and preferably the solid particulate material may be selected from barium sulfate (barite), calcium carbonate, dolomite, ilmenite, hematite, olivine, siderite, strontium sulfate, combinations and mixtures of these and other similar solids that should be apparent to one of skill in the art.
Patent EA-015334-B1 (EA)
Title: Antimicrobial, acid-catalyzed coating composition
Inventor: BRAY JAMES H III
IPC: C09D187/00
Filed: 2005-05-10
Abstract: The antimicrobial acid-catalyzed coating composition of the invention is an acid-catalyzed coating composition formulated with an aminoplast resin, a backbone resin, an acid catalyst, a carrier and an antimicrobial agent to provide antimicrobial activity to the coating composition and an article coated therewith.
Patent EA-012784-B1 (EA)
Title: Quaternary salt ccr2 antagonists
Inventor: LAGU BHARAT
IPC: C07D333/36
Filed: 2005-06-22
Abstract: Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
Patent EA-013250-B1 (EA)
Title: Inhibitors of c-fms kinase
Inventor: ILLIG KARL P
IPC: A61K31/4439
Filed: 2005-10-20
Abstract: The invention is directed to compounds of Formula (I):wherein A, X, Rand W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.
Patent EA-012925-B1 (EA)
Title: Non-destructive testing foundry products by ultrasound
Inventor: BISIAUX BERNARD
IPC: G01N29/04
Filed: 2007-06-25
Abstract: Non-destructive testing device for tubes. It collects information about the imperfections from signals which are continuously being captured by ultrasonic receivers following the selective excitation of ultrasonic emitters according to a selected time law. The receivers form a selected geometrical layout connected by ultrasound with the tube with relative rotation/translational movement. The device comprises a converter (891; 892) selectively isolating a numerical representation of echo signals in designated time windows, according to the movement, and creating an image (901; 902) of the imperfections, a filter (921; 922) that determines the presumed imperfection zones (Zcur) and their properties, a combiner (960) that prepares the digital work input signals from an extract (951; 952) from the images of the zone (Zcur) of the imperfection, the properties thereof taken from the filter, and context data (740), a neuronal circuit (970) that receives the work input signals, a digital stage (992) of the decision and signaling operating on the base of the neuronal circuit output signal, and an automated sorting and marking device (994) for the tubes considered to be substandard by the decision and signaling stage.
Patent EA-015372-B1 (EA)
Title: Suspension pocket spring system
Inventor: KILIC ERSEN
IPC: A47C27/06
Filed: 2007-08-24
Abstract: The invention relates to a suspension pocketed spring system to form flexible filler between platforms/layers containing first group of standard pocketed springs (10); second group of short pocketed springs (20) connected with the pocketed springs (10) of the first group and separate from each other in a manner a space (23) is formed between them.
Patent EA-015375-B1 (EA)
Title: Tyre with water projection diversion device
Inventor: D HARCOURT JEAN-MARC
IPC: B60C11/01
Filed: 2008-06-02
Abstract: The invention relates to a tyre (1) having a tread (2) with flanges (3) extending axially and radially towards the inside of the tread, the tread having a rolling surface (21) to be in contact with the ground during rolling and side faces axially extending on either side of the tread, wherein the tyre further includes on one flange thereof and in the vicinity of the tread a circumferential rib (4) for modifying the height of water projections in the transverse direction (corresponding to a direction parallel to the tyre rotation axis) in the case of rolling on wet ground. The circumferential rib (4) includes a device (5) for diverting the flow of water projections in case of rolling on a water-covered ground, wherein said device (5) is formed by a plurality of protrusions (51) protruding on said circumferential rib (4) and arranged in a direction oblique relative to the transverse direction. The circumferential rib (4) further includes a plurality of studs (6) for reducing the flow force when rolling on a water-covered ground, said studs (6) being provided between the protrusions of the diversion device (5).
Patent EA-018071-B1 (EA)
Title: Isomalt-containing mixture for producing rapidly disintegrating tablets, method for producing same and a tablet
Inventor: KOWALCZYK JOERG
IPC: A23L27/30
Filed: 2009-02-17
Abstract: The invention relates to a mixture containing isomalt containing a) 60-97% by weight of agglomerated isomalt, b) 1-25% by weight of cross-linked polyvinylpyrrolidone, c) 0,1-15 % by weight of lubricant, d) 1-15% by weight of water-insoluble, film-forming polymers, e) 0-15% by weight of water-soluble polymers and f) 0-15% by weight of pharmaceutical adjuvants, the sum of the components a)-f) adding up to 100% in weight. The invention also relates to a method for producing the mixture containing isomalt and to the tablets containing said mixture.
Patent EA-024586-B1 (EA)
Title: Methods for producing antibodies from plasma cells
Inventor: LANZAVECCHIA ANTONIO
IPC: C12N5/0781
Filed: 2009-10-22
Abstract: The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.
Patent EA-020552-B1 (EA)
Title: Method of preparing deoxyribofuranose compounds
Inventor: HALEY GREGORY J
IPC: A01N43/90
Filed: 2009-11-16
Abstract: The invention relates to methods for making deoxyribofuranose compounds such as compound (2) which are useful intermediates in the preparation of pharmaceutical compounds such as 5-amino-3-(2'-O-acetyl-3'-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.
Patent EA-019797-B1 (EA)
Title: Glass coating process and apparatus
Inventor: RAJALA MARKKU
IPC: B05D1/02
Filed: 2009-12-21
Abstract: The invention relates to a process and an apparatus for coating glass substrate (2) by using at least one or more liquid raw materials which react essentially on or in the vicinity of at least a portion of the glass substrate surface (10). The process comprises steps: a) heating the glass substrate (2) to at least substantially the coating temperature; b) forming a coating on the glass substrate surface (10) by converting the one or more liquid materials to a liquid-aerosol and depositing at least a fraction of the liquid-aerosol on the glass substrate surface (10); c) repeating step b) at least once; and d) heating the glass substrate surface (10) before at least one of the steps b). According to the invention the heating in step d) is carried out by convective heating.
Patent EA-025511-B1 (EA)
Title: Process for the production of estetrol intermediates
Inventor: PASCAL JEAN-CLAUDE
IPC: C07J75/00
Filed: 2012-06-01
Abstract: The present invention relates to a process for the preparation of a compound of formula (I)comprising the steps of a) reacting a compound of formula (II) with a silylating or an acylating agent to produce compound of formula (III), wherein Pis a protecting group selected from R-Si-RRor RCO-, wherein Ris a group selected from Calkyl or Ccycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; R, Rand Rare each independently a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl:b) halogenation or sulfinylation of the compound of formula (III) to produce a compound of formula (IV); wherein X is halo, or -O-SO-R, and Ris a group selected from Caryl or heteroaryl, each group being optionally substituted by one or more substituents independently selected from chloro or Calkyl:c) dehalogenation or desulfinylation of the compound of formula (IV) to produce a compound of formula (V)d) reacting the compound of formula (V) with a reducing agent to produce the compound of formula (I).
Patent EA-034039-B1 (EA)
Title: Site-specific integration host cell, method of production and use thereof
Inventor: RANCE JAMES
IPC: C12N15/90
Filed: 2013-06-20
Abstract: The present invention relates to stable and high-producing site-specific integration (SSI) host cells, e.g. Chinese hamster ovary (CHO)-derived host cells, and methods to produce and to use such cells.
Patent EA-025393-B1 (EA)
Title: Pyrazolyl-ureas as kinase inhibitors
Inventor: CARIOU CLAIRE ANNE MARIE
IPC: C07D403/12
Filed: 2013-08-16
Abstract: In the invention there are provided compounds of formula (I)wherein R, R, R, R, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
Patent EA-031632-B1 (EA)
Title: PROCESS FOR PREPARING METHYL-{4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-b]PYRIDINO-3-YL]PYRIMIDINO-5-YL}METHYLCARBAMATE
Inventor: MAIS FRANZ-JOSEF
IPC: C07D471/04
Filed: 2010-11-22
Abstract: The present invention relates to a process for preparing methyl{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate of formula (I)wherein 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine of the Formula (III)is cleaved by catalytic hydrogenation in the presence of a hydrogenation catalyst in a solvent selected from the group consisting of N,N-dimethylformamide, N,N-dimethylacetamide and N-methyl-2-pyrrolidone at the temperature of 40-80°C, pressure 2-90 bar and hydrogenation time 1-72 h, the obtained 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine of the Formula (VIII)after the catalyst filtration is precipitated from a C-Calcohol and/or water without intermediate formation of salts, then 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine of the Formula (VIII) is reacted with methyl chloroformate of the formula (V)to produce methyl-4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate of the Formula (VI)in a pyridine-free process and in the presence of a nitrogen-containing organic base, and the obtained methyl-4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate of the Formula (VI) is reacted with a methylating agent Me-X to form methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the Formula (I), wherein the methylating agent Me-X is selected from the group consisting of methyl iodide, dimethyl sulphate, and methyl toluenesulphonate.
Patent EA-027662-B1 (EA)
Title: Pane with thermal radiation reflecting coating
Inventor: HAGEN JAN
IPC: G02B1/11
Filed: 2013-12-19
Abstract: The present invention relates to a pane with thermal radiation reflecting coating, comprising at least one substrate (1) and at least one thermal radiation reflecting coating (2) at least on the interior-side surface of the substrate (1), wherein the pane has transmittance in the visible spectral range of less than 5%, and the coating (2), proceeding from the substrate (1), comprises at least an adhesive layer (3) that contains at least one material with a refractive index of less than 1.8, a functional layer (4) that contains at least one transparent electrically conductive oxide, an optically high-refractive-index layer (5) that contains at least one material with a refractive index greater than or equal to 1.8, and an optically low-refractive-index layer (6) that contains at least one material with a refractive index of less than 1.8.
Patent EA-032396-B1 (EA)
Title: Composite profile and method for producing a composite profile
Inventor: GEBESMAIR KARL
IPC: E06B3/22
Filed: 2014-10-06
Abstract: The present invention relates to a composite profile made of plastics, designed as a hollow profile with at least two reinforcing strips arranged in the interior, characterized in that the at least two reinforcing strips (1A, 1B) are formed at least partially of thermoplastic plastic with embedded continuous glass and/or mineral fibers and/or other reinforcing fibers; and at least one of the reinforcing strips (1A, 1B) has at least one angled section (5A, 5B) parallel to the longitudinal axis of the composite profile (10), wherein the distance (A) between the at least two reinforcing strips (1A, 1B) and the respective adjacent outer walls (11) of the composite profile (10) in the region of the non-angled section corresponds to 0.1 to 3 times the wall thickness (D) of the outer wall (11). The present invention also relates to a reinforcing strip for a composite profile and to a method for producing a composite profile.
Patent EA-035473-B1 (EA)
Title: Method for controlling a flow of a proportional valve of ventilator
Inventor: KONG DEYU
IPC: G05D16/20
Filed: 2016-04-15
Abstract: Provided is a method for controlling a flow of a proportional valve of a ventilator, comprising the following steps: step 1) acquiring a minimum flow value a and a maximum flow value b of the proportional valve, as well as corresponding driving voltage values thereof; evenly dividing an interval of [a, b] into N flow segment intervals, acquiring voltages at left endpoints of the N intervals by linear fitting as feedforward voltages, calculating a driving voltage corresponding to the flow at the left endpoint of each interval by a closed-loop control algorithm with the feedforward voltage as an initial voltage, and then linearly fitting the flows and the driving voltages of the N intervals, thereby establishing a linear relationship between the flow and the driving voltage of the proportional valve of the ventilator; step 2) firstly finding, according to the flow value of the proportional valve that needs to be outputted, the flow segment interval on which the flow value lies, and then calculating the driving voltage value corresponding to the flow value according to the fitted linear relationship; and step 3) adjusting a voltage of the proportional valve to the driving voltage value obtained in step 2), then the flow outputted by the proportional valve meets the requirements.
Patent EA-033870-B1 (EA)
Title: Pumping machine comprising an electromechanical lifting system
Inventor: MARRALE CARMELO
IPC: B66F3/44
Filed: 2016-10-06
Abstract: Pumping machine (650, 750) comprising at least two tubular elements (651, 751) containing pressurized gas and extending vertically in parallel and interconnected between them by means of a connecting element (652, 752); and an electromechanical lifting system (600, 700) comprising a first cylinder (601, 701), interconnected to the tubular elements (651, 751) and comprising a substance compressible by a piston (601b, 701b); and a screw (602, 702) with a vertical axis Y coinciding with the axis of the pumping machine (650, 750). The screw (602, 702) is inserted inside a second thrust cylinder (658, 758), connected in sliding manner inside the first cylinder (601, 701), and has a first end (602b, 702b) fixed to the connecting element (652, 752) and a second end (602a, 702a) configured for sliding inside the thrust cylinder (658, 758) and overlying a chamber (605, 705) comprising lubrication and cooling oil overlying the piston (601b, 701b).
Patent ES-2166311-B1 (ES)
Title: Maquina de grabacion de imagenes y sonidos, accionada por monedas o fichas, y procedimiento correspondiente.
Inventor: ROCA ROCA JOSEP
IPC: G07F17/28
Filed: 2000-02-16
Granted: 2003-06-16
Abstract: Máquina de grabación de imágenes y sonidos, accionada por monedas o fichas, y procedimiento correspondiente. Las grabaciones producidas quedan sólo a disposición del administrador, sin que el usuario reciba, in situ, ninguna reproducción de la grabación; la caja externa incluye además en su interior: un dispositivo de iluminación secundaria; una caja de control centralizado del funcionamiento de la máquina, comprendiendo la caja de control una fuente de alimentación, un microprocesador con un módulo de gestión de alarmas, un temporizador de grabación y elementos de circuito que conectan los distintos dispositivos eléctricos de la máquina al microprocesador para recibir de éste señales de alimentación y/o activación y para enviarle, en su caso, señales de detección. El procedimiento se basa en tres modos de funcionamiento diferentes, a saber normal, de servicio y de alarma. Aplicable para proporcionar grabaciones al administrador de la máquina y sólo eventualmente al usuario.
Patent ES-2177389-B1 (ES)
Title: Airbag trasero pre-inflado.
Inventor: GRAS TOUS LUIS
IPC: B60R21/02
Filed: 2000-04-12
Granted: 2004-08-16
Abstract: Airbag trasero pre-inflado (1) que consiste en un continente (2) pre-llenado de cualquier producto capaz de absorber la energía, posicionado en un emplazamiento cualquiera, como parte integral o accesorio, activado por medios mecánicos liberadores de la energía almacenada, disponiendo de salidas de gas o de cualquier otro, método de absorción para el control de la fuerza de retención.
Patent ES-2181552-B1 (ES)
Title: Aparato y procedimiento para detectar el recalentamiento de transistores de potencia de un inversor.
Inventor: LEE DONG-KUE
IPC: H02H3/08
Filed: 2000-09-28
Granted: 2004-06-01
Abstract: Aparato y procedimiento para detectar el recalentamiento de transistores de potencia de un inversor conectado con una fuente de alimentación de tal manera que se conecte/desconecte dicha fuente de alimentación a una carga según una entrada de señal de control, que comprende: una unidad de resistencia dispuesta en un circuito de corriente eléctrica formado desde la alimentación de corriente eléctrica hasta los transistores de potencia; un integrador para integrar la señal remanente que se obtiene sustrayendo una primera señal de referencia de una señal de voltaje generada en los dos extremos de la unidad de resistencia; una sección de comparación para producir un resultado que se obtiene después de comparar una señal de salida del integrador con una segunda señal de referencia; y una sección de control para desconectar los transistores de potencia cuando determinan la señal producida por la sección de comparación que corresponde a una señal de recalentamiento.
Patent ES-2178935-B1 (ES)
Title: Dispositivo cortafuego que forma un elemento de conducto.
Inventor: WEPIERRE KARIN
IPC: A62C2/24
Filed: 2000-11-03
Granted: 2004-04-01
Abstract: Dispositivo cortafuego que forma un elemento de conducto obturable, destinado a ser instalado en un sistema de aireación de inmueble. Según la invención, el dispositivo comprende un cajón provisto de dos accesos (14, 15), que aloja un cuerpo obturador (17) sensiblemente cilíndrico y en cuyo interior está definido un tramo de conducto (18), estando montado el citado cuerpo obturador dentro de una cavidad (28) del cajón y siendo accionado por medios de mando de rotación.