Patent SG-11201903785T-A (SG)
Title: Bivalent antibodies masked by coiled coils
Inventor: TRANG VIVIAN
IPC: C07K16/46
Filed: 2017-12-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111 11111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/107125 Al 14 June 2018 (14.06.2018) W I PO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/46 (2006.01) C07K 16/18 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 16/28 (2006.01) A61K 39/395 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/065471 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 08 December 2017 (08.12.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/432,472 09 December 2016 (09.12.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: SEATTLE GENETICS, INC. [US/US]; UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 21823 30th Drive SE, Bothell, Washington 98021 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: TRANG, Vivian; 21823 30th Drive SE, Both- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, ell, Washington 98021 (US). LEVENGOOD, Matthew R.; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 21823 30th Drive SE, Bothell, Washington 98021 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, _ SENTER, Peter; 21823 30th Drive SE, Bothell, WA 98021 KM, ML, MR, NE, SN, TD, TG). (US). = Declarations under Rule 4.17: (74) Agent: LIEBESCHUETZ, Joe et al.; Alston & Bird LLP, _ as to the identity of the inventor (Rule 4.17(1)) = 101 South Tryon Street, Bank of America Plaza, Suite 4000, _ as to the applicant's entitlement to claim the priority of the Charlotte, North Carolina 28280-4000 (US). earlier application (Rule 4.17(iii)) = (54) Title: BIVALENT ANTIBODIES MASKED BY COILED COILS A. = = 30000 = e s . 20000 - g _ s = 1 -1000 0 (57) : The invention provides bivalent antibodies including two light and heavy chain pairs. The N-termini of one or both light and heavy chain pairs are linked via linkers comprising a protease cleavage site to coiled-coil HT-2 cells forming peptides that associate to form a coiled coil reducing binding affinity -F- 145-2C11 of at least one light-heavy chain pair to a target. -1- Vel-IPM-145-2011 = = = B. = - 0.001 0.01 0.1 1 10 100 1000 10000 nM Mouse PK 1 mg/kg, IV -.- 145-2G11 ,., .- VN-IPV-145-2G11 = k- mlpG2A latogye 11 ir) N 5000 /1 4000 IN k 11 .0 ---.... ©2000 . 14 Time lo.r0 15 D IFN-ry +I• CV•12C11 j 00 IL - 2 ...- 2011 WAG.) ••• OV•12C11 4 0 20 2a a 8 12 0 Ho urs 26 /1 © N C [Continued on next page] WO 2018/107125 Al MIDEDIMOMMIDEFIE30101EIEHOHOMEMOIS Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))