Patent SG-11201408287R-A (SG)
Title: Rapid specific pathogen free animal
Inventor: UNG ENG HUAN
IPC: C07K19/00
Filed: 2013-06-25
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/003538 A1 (51) International Patent Classification: A01K 67/027 ( 2006.01) C07K19/00 (2006.01) A61K 38/17 (2006.01) C12N15/62 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/MY2013/000116 25 June 2013 (25.06.2013) English English (30) Priority Data: PI2012002924 26 June 2012 (26.06.2012) MY (71) Applicant: BIOVALENCE SDN. BHD. [MY/MY]; 21, Jalan SS25/34, Taman Mayang Industrial Park, Petaling Jaya 47301 (MY). (72) Inventors: UNG, Eng Huan; No. 2, Lorong Ujana King­ fisher 9, Kingfisher Ujana, Kota Kinabalu 88300, Sabah (MY). ABU BAKAR, Ag., Muhammad Sagaf; P.O. Box 81, Pos Mini, Central Plaza, Kota Kinabalu 88300, Sabah (MY). (74) Agents: JEFFREY, Fiona, Teresa et al.; Marks & Clerk (Malaysia) Sdn Bhd, P.O. Box 11182, Kuala Lumpur 50738 (MY). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: RAPID SPECIFIC PATHOGEN FREE ANIMAL 00 m m o o o CJ o & 10 1) 12 13 14 Control Treated (57) Abstract: A method of producing at least one specific pathogen free (SPF) non-human animal and/or method of producing a at least one specific pathogen resistant (SPR) non-human animal, the method comprising administration of a fusion protein the to sur­ viving animal wherein the fusion protein comprises at least one polypeptide B which is a Type 1 Ribosome Inactivating Protein (RIP) or fragment thereof; and (i) at least one polypeptide A which an Antimicrobial peptide; is and/or (ii) at least one polypeptide C which is a Cationic Antimicrobial Peptide (CAP) or fragment thereof.