baber/WOPTO huggingface dataset:
Patent EA-005646-B1 (EA)
Title: High speed non-concurrency controlled database
Inventor: BALOGH ARISTOTLE NICHOLAS
IPC: G06F17/00
Filed: 2002-11-01
Abstract: The present invention describes a method and system for high-speed database search with concurrent update, without the use of database locks or access controls, for large database systems. System (100) consists of a plurality of processors (102-1 ... 102-p) coupled to bus (101; a plurality for secondary memory caches (103-1 ...103-p); memory (i.e., RAM)(104); read only memory (ROM) (106); a storage device (108; display i.e., LCD monitor) (110); input device (112); network interfaces (114-1 ...114-O) which may send/ receive electrical signals that represent various information; a wide area network (124); a local area network (LAN) (122); a plurality of network computers (120-1 ...120-N front-end protocol engines; and multiple on-line transaction processing (OLTP) servers (140-1 ... 140-S) to receive update traffic to databases (142-1 ... 142-S).
Patent EA-008448-B1 (EA)
Title: Novel benzoimidazole derivatives useful as antiproliferative agents
Inventor: KATH JOHN CHARLES
IPC: C07D405/14
Filed: 2003-08-14
Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R, R, and Rare as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
Patent EA-008904-B1 (EA)
Title: Process for the desulfurization of light fcc naphtha
Inventor: SOM MANOJ
IPC: C10G45/58
Filed: 2004-09-28
Abstract: A process for the treatment of a light cracked naphtha is disclosed wherein the light cracked naphtha is first subjected to thioetherification and fractionation into two boiling fractions. The lower boiling fraction is removed as overheads for later recombination with the product and the higher boiling fraction is combined with a heavy cracked naphtha and subjected to simultaneous hydrodesulfurization and fractionation to separate the higher boiling fraction from the heavy cracked naphtha which is recycled. The recycled heavy cracked naphtha is eventually desulfurized and hydrogenated to produce a clean solvent which washes the catalyst and extends catalyst life.
Patent EA-011091-B1 (EA)
Title: Pyrazolopyrimidinethione derivatives, salts and solvates thereof, preparation methods and use thereof
Inventor: LI SHUXIN
IPC: C07D487/04
Filed: 2004-11-18
Abstract: This invention relates to pyrazolopyrimidinethione derivatives, salts and solvates thereof, preparation methods and use thereof. The pyrazolopyrimidinethione derivatives according to the present invention posses the structure of general formula 1, wherein, R, R, Rare same or different, and independently are C-Calkyl; Ris C-Calkyl; Ris C-Calkyl; Ris hydrogen, alkyl having 1-6 carbon atoms, alkenyl having 3-6 carbon atoms, cycloalkyl having 3-8 carbon atoms, or alkyloyl having 1-6 carbon atoms.The pharmaceuticals containing the compound of the present invention and used for the treatment of impotence and sexlessness have the advantages of high selectivity over PDEV, long action time, less side reactions, and the pharmaceuticals will arouse no side reactions of blood pressure decreasing and heart rate increasing, and it has broad market prospect.
Patent EA-011636-B1 (EA)
Title: Kynurenic acid amide derivatives as antagonists of nr2b subtype of nmda receptor
Inventor: BORZA ISTVAN
IPC: C07D401/06
Filed: 2005-07-21
Abstract: The new kynurenic acid amide derivatives of formula (I):and optical antipodes, racemates and the salts thereof are highly effective and selective antagonists of NMDA receptor, and moreover most of the compounds are selective antagonist of NR2B subtype of NMDA receptor.
Patent EA-010561-B1 (EA)
Title: Method for treating soils, in particular dry soils
Inventor: JOLY CLAUDE
IPC: E02D3/12
Filed: 2006-02-20
Abstract: The invention concerns a method for treating soils, in particular water-sensitive dry soils, comprising burying a treatment liquid, optionally loaded with a suspended material into trenches and a device for implementing said method. The device comprises a transportable chassis (2), a reservoir and hollow dispensing tines (1). The dispensing tines comprise a vertical supporting portion (3) which connects said dispensing tines (1) to the chassis and a horizontal share portion (4), including a tip (5) prior to penetrating into the soil, and a rear dispenser (6).
Patent EA-011992-B1 (EA)
Title: Fusion protein of antibody l19 against fibronectin ed-b and interleukin 12
Inventor: NERI DARIO
IPC: A61K47/48
Filed: 2006-05-03
Abstract: Conjugate for targeting therapeutic or diagnostic agent or drug to cells or tissues in a body, e.g. areas of neoplastic growth or angiogenesis. Use of conjugate for in vivo diagnosis or therapy e.g. inhibiting tumour growth or metastasis, inhibiting angiogenesis and/or treating cancer. Conjugate comprises therapeutic or diagnostic agent as oligomeric protein e.g. heterodimeric protein, wherein first and second subunits of protein are each conjugated to a specific binding member e.g. an antibody fragment such as scFv. Subunits of oligomer may be conjugated to specific binding members as fusion proteins. Conjugate may comprise IL-12 heterodimer having two subunits, each subunit fused to scFv L19 or TN11 for targeting IL-12 to extracellular matrix components associated with neoplastic growth and angiogenesis.
Patent EA-018608-B1 (EA)
Title: Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivative and dpp iv inhibitor
Inventor: DUGI KLAUS
IPC: A61K31/00
Filed: 2008-08-15
Abstract: The invention relates to a pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivative 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene in combination with a DPP IV inhibitor 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-aminopiperidin-1-yl)xanthine or a pharmaceutically acceptable salt thereof, suitable in the treatment or prevention of one or more pathologic conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia, metabolic disorders and related pathologic conditions.
Patent EA-017284-B1 (EA)
Title: Treatment of banana and potato plants with a new antifungal composition
Inventor: STARK JACOBUS
IPC: A01N43/90
Filed: 2008-12-19
Abstract: The present invention relates to the treatment of banana and potato plants with a composition containing natamycin and at least one phosphite containing compound.
Patent EA-021552-B1 (EA)
Title: Sliding plug door mechanism
Inventor: TUKIAINEN ARI
IPC: E05D15/10
Filed: 2011-02-18
Abstract: Sliding plug door mechanism, comprising guide means (1) having a first guide means section (2a) and a second guide means section (2b). The mechanism includes a lever element (3) arranged to move with a door panel (10, 10a, 10b), the lever element (3) comprising a first and a second joint (4, 5). The first joint (4) is arranged to couple an actuator of the mechanism to the lever element (3) and the second joint (5) is arranged to move in/on the guide means. The second joint (5) is a turning joint connected to a door panel carriage (13, 13a, 13b) fixed non-rotatably to the door panel (10, 10a, 10b). The lever element (3) is arranged to rotate relative to said door panel carriage (13, 13a, 13b) as a result of the movement of the lever element (3) from the first guide means section (2a) to the second guide means section (2b).
Patent EA-018253-B1 (EA)
Title: Fluid display having a central reservoir
Inventor: BITMAN ANDRIY
IPC: G02B26/02
Filed: 2009-08-06
Abstract: The invention relates to a display device (1) based on the use of fluids for visualizing information. In order to ensure simple exchangeability of fluids, the invention provides a central fluid reservoir (6) which may be utilized in combination with a fluid display device (1) of any desired design. For this purpose, the central fluid reservoir (6) is coupled to the fluid display elements, which can be refilled with the colored fluid.
Patent EA-025765-B1 (EA)
Title: Thermosetting compositions containing isocyanurate rings
Inventor: ZHAO MING-YANG
IPC: C08G59/42
Filed: 2010-03-26
Abstract: The invention relates to an epoxy-functional thermosetting composition containing isocyanurate ring(s), wherein it comprises the reaction product of: (a) a polyepoxide containing at least two epoxide groups per molecule; (b) a carboxyl functional oligomer comprising the reaction product of an equivalent quantity of: (i) a polyol containing isocyanurate ring(s) comprising the reaction product of a tris-(2-hydroxyalkyl)isocyanurate with a modifier, wherein the modifier is a caprolactone, and (ii) an acid anhydride; and (c) an unsaturated carboxylic acid; wherein the molar ratio of epoxy functional groups in component (a) to acid functional groups in component (b) is greater than 1.0, wherein the said acid anhydride is selected from the group consisting of maleic anhydride, succinic anhydride, dodecenylsuccinic anhydride, itaconic anhydride, citraconic anhydride, adipic anhydride, hexahydrophthalic anhydride, methylhexahydrophthalic anhydride, nadic anhydride, methylnadic anhydride, tetrahydrophthalic anhydride, methyltetrahydrophthalic anhydride, phthalic anhydride and tetrachlorophthalic anhydride, and wherein the unsaturated carboxylic acid is selected from acrylic acid and methacrylic acid. The epoxy-functional thermosetting composition can be modified with a polyisocyanate to produce a composition that is useful as a reactive adhesive, binder or in other applications.
Patent EA-022901-B1 (EA)
Title: Wear plate fastening system, arrangement and method
Inventor: FERNANDEZ RICARDO FRANCISCO DOBERTI
IPC: B02C17/22
Filed: 2011-04-19
Abstract: In the invention a wear plate system comprises a wear plate for mounting to the inside of a grinding mill. A fastening arrangement comprises an elongate coupling member having a first end arranged to secure to the wear plate such that when so secured the coupling member is arranged to pivot with respect to the wear plate. A second end of the elongate coupling member secures to the grinding mill.
Patent EA-021573-B1 (EA)
Title: Electrically operated machine for covering book covers and sealing envelopes
Inventor: FARNETI ALDO
IPC: B65B51/14
Filed: 2011-11-22
Abstract: A machine is described for covering book covers and sealing envelopes or articles of various kind. The machine comprises a fixed lower base (1) suitable for resting a sheet of flexible plastic material, single or unwindable from a roll, for an article to be covered, an upper part (3) movable towards said base (1) and a heatable blade (7) accommodated in said upper part (3) to execute the soldering of the overlapped ends of the plastic material sheet along the edges of said article when said upper part (3) is approached to said lower base (1). To approach the upper part (3) to the lower base (1), the machine comprises an electric motor (9), a control member (20) accessible from the outside of the machine for operating said electric motor (9) and movement transmission means (21-26) acting on the sides (11) of said upper part (3) to induce, at every activation of said electric motor (9) determined by said control member (20), an approaching movement of said upper part (3) towards said lower base (1) for executing the soldering of the ends of the plastic material sheet.
Patent EA-024421-B1 (EA)
Title: N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide and pharmaceutically acceptable salts thereof as egfr modulators useful for treating cancer
Inventor: BUTTERWORTH SAM
IPC: C07D401/02
Filed: 2012-07-25
Abstract: The present invention relates to N-(2-{2-dimethylaminoethy1-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideand pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compound or a pharmaceutically acceptable salt thereof and to the use of said compound or a pharmaceutically acceptable salt thereof as L858R EGFR mutant inhibitor, and/or T790M EGFR mutant inhibitor, and/or EGFR mutant inhibitor with Exon19 deletion or for the manufacture of a medicament for the treatment of cancer.
Patent EA-030039-B1 (EA)
Title: Advertisement device for outdoor advertising on motor vehicles
Inventor: GRITSYUK VLADIMIR VLADIMIROVICH
IPC: G09F21/04
Filed: 2014-05-27
Abstract: The invention can be used for advertisement of goods or services on trucks, station wagons and pick-up cars. The objective of the invention is reduction of cost of outdoor advertisement on motor vehicles and reduction of interference that influence detrimentally the visibility of advertising information for potential consumers of advertised goods or services while providing high reliability of the device operation. The device for outdoor advertising on motor vehicles comprises a device for detachable fastening of the advertisement device to a motor vehicle, two protective elements made of a transparent flexible polymer material, two support elements supporting graphical advertising information, a device for detachable fastening of elements of a graphical advertising information carrier, and a graphical advertising information illuminating device. The majority of parts of the device for outdoor advertising on motor vehicles are made of a flexible non-metal material.
Patent EA-029157-B1 (EA)
Title: Baclofen and acamprosate based therapy of macular degeneration
Inventor: COHEN DANIEL
IPC: A61P27/02
Filed: 2013-07-18
Abstract: The present invention relates to combinations and methods for the treatment of macular degeneration disorders. More specifically, the present invention relates to novel combinatorial therapies of Age related Macular Degeneration based on baclofen and acamprosate combination.
Patent EA-027776-B1 (EA)
Title: Use of an electrically conductive layer based on tin oxide in an antireflection or reflective coating of an optical article
Inventor: CONTE DOMINIQUE
IPC: G02B1/11
Filed: 2010-03-26
Abstract: The object of the present invention is the use of an electrically conductive layer comprising at least 30 wt.% tin oxide (SnO) relative to the total weight of the electrically conductive layer, in an antistatic antireflection or reflective coating coated on at least one main surface of an optical article substrate having a water uptake rate at least 0.6 wt.% relative to the total weight of said substrate, the water uptake rate being measured after predrying said substrate and then storing it for 800 hours in a closed chamber at 50°C under 100% relative humidity and at atmospheric pressure, as a means for retaining transparency of said coating or preventing developing cosmetic defects in an optical article.
Patent EA-032619-B1 (EA)
Title: System and method for high efficiency power generation using carbon dioxide as circulating working fluid
Inventor: ALLAM RODNEY JOHN
IPC: F02C3/34
Filed: 2011-01-26
Abstract: The application describes methods and a system for power generation using a high efficiency combustor in combination with a COcirculating fluid. The methods and systems advantageously can make use of a low pressure ratio power turbine and an economizer heat exchanger in specific embodiments. Additional low grade heat from an external source can be used to provide part of an amount of heat needed for heating the recycle COcirculating fluid. Fuel derived COcan be captured and delivered at pipeline pressure. Other impurities can also be captured.
Patent EA-031395-B1 (EA)
Title: Modified release formulation
Inventor: GALLI BRUNO
IPC: A61K31/4439
Filed: 2014-06-11
Abstract: Proposed are medicinal products in the form of modified release formulations comprising the drug substance (-)-(3aR,4S,7aR)-4-hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such medicinal products. The medicinal products are useful in treating patients suffering from Parkinson's disease and exhibiting L-dopa induced dyskinesia.
Patent EA-035271-B1 (EA)
Title: Airflow adaptor for a breath-actuated dry powder inhaler
Inventor: BLAIR JULIAN ALEXANDER
IPC: A61M15/00
Filed: 2010-11-05
Abstract: An airflow adaptor (200) for a breath-actuated dry powder inhaler is described. The airflow adaptor comprises a conduit (202) having a proximal end (201) and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further comprises means (204, 205, 206, 210, 211, 212) for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
Patent EA-037029-B1 (EA)
Title: Fluorescent labeled single-stranded nucleic acid and use thereof
Inventor: HANAMI Takeshi
IPC: C12Q1/68
Filed: 2015-03-27
Abstract: The present invention is intended to provide a novel fluorescent labeled single-stranded nucleic acid, by which the background of an exciton oligomer can be further reduced, and the novel use thereof. The present invention relates to a labeled single-stranded nucleic acid having at least two fluorescent atomic group pairs that exhibit an exciton effect. The labeled single-stranded nucleic acid is characterized in that the emission peak wavelength of one of the fluorescent atomic group pairs (fluorescent atomic group pair A) is shorter than the excitation peak wavelength of the other fluorescent atomic group pair (fluorescent atomic group pair B), and the fluorescent atomic group pairs A and B have a Forster resonance energy transfer (FRET) effect. This fluorescent labeled single-stranded nucleic acid is usable as a primer for amplifying a target nucleic acid or a probe to be hybridized with a target nucleic acid.
Patent EA-030312-B1 (EA)
Title: Vehicle
Inventor: KRIKUN GENNADY PAVLOVICH
IPC: B62M5/00
Filed: 2017-06-19
Abstract: The invention is related to vehicles driven by a human muscle force. A wheeled vehicle is designed comprising a frame (2), at least one drive wheel (3) and rocking pressure levers (5) mounted on the frame (2) and linked to the drive wheel (3) by means of draw bars (12), wherein the rocking pressure lever (5) is a double-arm lever, its first arm (6) is made so as to receive muscle force applied to it, and the second arm (7) carries a rotatable double-arm drive lever (8); the first end of the draw bar (12) is linked to the first arm (11) of the drive lever (8), and its second end (28) is linked to the draw bar return element (30) through a movable sleeve mounted on the shaft (14) of the drive wheel (3) and rotatable in one direction; and the second arm (15) of the drive lever (8) is connected to the tension unit for tensioning the drive lever (8). The design of the vehicle makes it possible to increase its efficiency and to provide the possibility for the driver to select an optimum for himself transmission ratio and smooth variation of the transmission ratio.
Patent EA-031319-B1 (EA)
Title: Active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate and dimesylate dihydrate salt of active metabolite
Inventor: NIROGI RAMAKRISHNA
IPC: C07D209/14
Filed: 2014-10-20
Abstract: The present invention is directed to active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate having the following structure:The present invention is also directed to dimesylate dihydrate salt of formula (I) having the following structure:The compounds of formula (I) and formula (II) are useful in the treatment of various disorders that are related to 5-HTreceptor antagonist.
Patent EA-031895-B1 (EA)
Inventor: TATLOCK JOHN HOWARD
IPC: C07H19/24
Filed: 2016-02-15
Abstract: Предложены соединения общей формулы (I)или их фармацевтически приемлемая соль, где значения Q, U, X, Y, Z, V, W, R, R, R, m и n такие, как определено в формуле изобретения, содержащая их фармацевтическая композиция для лечения рака, способ лечения аномального клеточного роста у млекопитающего, включающий введение терапевтически эффективного количества указанных соединений, а также применение этих соединений для изготовления лекарственного средства, полезного в лечении аномального клеточного роста у млекопитающего.
Patent EA-034914-B1 (EA)
Title: Jak kinase inhibitor compounds for treatment of respiratory disease
Inventor: FATHEREE PAUL R
IPC: C07D471/04
Filed: 2016-11-02
Abstract: The invention relates to compounds of formula (I)wherein the variables have the meanings defined in the claims, or pharmaceutically-acceptable salts thereof, that are useful as JAK kinase inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds for treating an inflammatory or fibrotic respiratory disease, the use of such compounds for treating an inflammatory or fibrotic respiratory disease in a mammal and processes for preparing the compounds and intermediates useful for preparing such compounds.
Patent EA-038619-B1 (EA)
Title: Device for melt separation
Inventor: ZHAUTIKOV BAKHYT AKHATOVICH
IPC: B22D41/08
Filed: 2019-02-04
Abstract: The invention relates to metallurgy, in particular, to equipment, namely to the separation of metal from slag in a tundish ladle during continuous steel casting. The device for metal-slag separation in the form of a perforated pipe 2 is shown in the seat 1 in the figure. The bottom of the tundish ladle 3 is the main load-carrying structure. The cover 4 is made as a steel semi-cylinder of a steel sheet 0.1-1.5 mm thick, with an inner diameter equal to 1.05-1.15 of the perforated pipe outside diameter. Holes for the depressurization of the device inner space are located below the cover level. This device allows for metal-slag separation, thereby improving the quality of steel slabs and preventing an emergency situation is case of a "breakout".
Patent EA-038888-B1 (EA)
Title: Pyrazole derivatives as bromodomain inhibitors
Inventor: ATKINSON STEPHEN JOHN
Filed: 2018-02-27
Abstract: The invention relates to pyrazole derivatives of formula (I)pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases.
Patent ES-2187320-B1 (ES)
Title: Peptido cationico anfipatico y su aplicacion en vectores de transferencia genica.
Inventor: FOMINAYA GUTIERREZ JESUS
IPC: C07K14/47
Filed: 2000-07-20
Granted: 2004-09-16
Abstract: Péptidos catiónicos anfipáticos y su aplicación en vectores de transferencia génica. Estos péptidos comprenden unos restos de aminoácidos básicos, alifáticos y aromáticos, unos restos de aminoácidos básicos en los dos extremos del péptido y, preferentemente, un resto de un aminoácido aromático en la posición 3 de la secuencia del péptido. Estos péptidos tienen simultáneamente la capacidad de unir un polinucleótido y alterar membranas biológicas y son útiles para construir vectores no virales de transferencia génica, con una capacidad de condensación de material genético mejorada, y/o con una citotoxicidad reducida y/o con una eficiencia de transferencia de material genético mejorada. De aplicación en la transferencia génica con fines experimentales y terapéuticos.