Patent SG-11201811178U-A (SG)
Title: Adenoviral vector
Inventor: GILBERT SARAH C
IPC: C12N15/861
Filed: 2017-06-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 December 2017 (28.12.2017) WIP0 I PCT omit VIII Hot o III om OH Holm Imo lII ois (10) International Publication Number WO 2017/221031 Al (51) International Patent Classification: C12N 15/86 (2006.01) A61K 39/12 (2006.01) C12N 15/861 (2006.01) A61K 39/02 (2006.01) (21) International Application Number: PCT/GB2017/051851 (22) International Filing Date: 23 June 2017 (23.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1610967.0 23 June 2016 (23.06.2016) GB (71) Applicant: OXFORD UNIVERSITY INNOVATION LIMITED [GB/GB]; Buxton Court, 3 West Way, Botley Oxfordshire OX2 OJB (GB). (72) Inventors: GILBERT, Sarah C; The Jenner Institute Lab- oratories, ORCRB, Roosevelt Drive, Oxford Oxfordshire OX3 7DQ (GB). HILL, Adrian, VS; The Jenner Institute Laboratories, ORCRB, Roosevelt Drive, Oxford Oxford- shire OX3 7DQ (GB). COTTINGHAM, Matthew, G; The Jenner Institute Laboratories, ORCRB, Roosevelt Drive, Oxford Oxfordshire OX3 7DQ (GB). DICKS, Matthew; The Jenner Institute Laboratories, ORCRB, Roosevelt Dri- ye, Oxford Oxfordshire OX3 7DQ (GB). MORRIS, Susan, J; The Jenner Institute Laboratories, ORCRB, Roosevelt Drive, Oxford Oxfordshire OX3 7DQ (GB). DOUGLAS, Alexander; The Jenner Institute Laboratories, ORCRB, Roosevelt Drive, Oxford Oxfordshire OX3 7D (GB). (74) Agent: GILL JENNINGS & EVERY LLP et al.; The Broadgate Tower, 20 Primrose Street, London Greater Lon- don, EC2A 2ES (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: ADENOVIRAL VECTOR (57) : The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector compris- ing the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orfl, E4Orf2 and E4Orf3 coding regions from AdY25. [Continued on next page] W O 20 17 / 22103 1 A WO 2017/221031 Al 0111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))