baber/WOPTO huggingface dataset:
Patent CA-2484176-A1 (CA)
Inventor: HAGER JOERG
IPC: C12Q1/68
Filed: 2003-05-14
Abstract: La présente invention concerne l'identification d'un gène humain de prédisposition à l'obésité, qui peut être utilisé dans le diagnostic, la prévention et le traitement de l'obésité et de troubles associés ainsi que dans le criblage de médicaments thérapeutiques. Cette invention concerne, plus spécifiquement, le gène PPYR1 sur le chromosome 10 et certains allèles dudit gène qui sont associés à la prédisposition à l'obésité et représentent de nouvelles cibles pour une intervention thérapeutique. La présente invention concerne des mutations spécifiques dans le gène PPYRl et des produits d'expression ainsi que des outils et trousses de diagnostic fondés sur ces mutations. Ladite invention peut être utilisée dans la détection, la prévention et/ou le traitement de la coronaropathie et de troubles métaboliques, y compris l'hypoalphalipoprotéinémie, l'hyperlipidémie familiale combinée, le syndrome de résistance à l'insuline (syndrome X) ou des troubles métaboliques multiples, la coronaropathie, le diabète et l'hypertension dyslipidémique, ainsi que dans le diagnostic de la prédisposition à ces maladies.
Patent CA-2484695-A1 (CA)
Inventor: ZHAO YONGHUA
IPC: A61B3/107
Filed: 2003-05-07
Abstract: Dans l'un des modes de réalisation de l'invention, un balayeur destiné à un faisceau de balayage de rayonnement tomographique par cohérence optique ( OCT ) comprend: (a) une source de rayonnement OCT; (b) un balayeur; et (c) une optique de balayage dont la surface d'image possède une courbure de champ négative.
Patent CA-2484760-A1 (CA)
Title: Increasing host plant susceptibility to acrobacterium infection by overexpression of the arabidopsis vip1 gene
Inventor: CITOVSKY VITALY
IPC: C07K14/415
Filed: 2003-05-09
Abstract: The present invention is directed to methods and compositions which employ an Arabidopsis VIP1 gene or VIP1-like gene from another plant species for purposes of increasing host plant susceptibility to Agrobacterium infection.  Methods for increasing susceptibility of a host to Agrobacterium infection and methods for improving Agrobacterium-mediatedgene transfer are provided. Also provided are chimeric genes and expression vectors that, upon introduction into a plant cell, enable the plant cell to become more susceptible to Agrobacterium infection and thus better transformed via Agrobacterium-mediated gene transfer. Transgenic plant cells and plants regenerated therefrom which overexpress a VIP1 or VIP1 -like gene are also provided.
Patent CA-2485514-A1 (CA)
Title: Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces
Inventor: DAVIDSON JAMES
IPC: A61F2/00
Filed: 2003-05-30
Abstract: Cephalad and caudal vertebral facet joint prostheses (36 and 38) and methods of use are provided. The prostheses provide an artificial facet joint structure including an artificial articular configuration unlike the preexisting articular configuration. The radii and material stress values of the prostheses are configured to sustain contact stress. The cephalad prosthesis (36) provides for posterior-anterior adjustment. Both prostheses permit lateral adjustment and adjustment to accommodate interpedicle distanc e. Further, the prostheses may be customized to provide a pre-defined lordotic angle and a pre-defined pedicle entry angle.
Patent CA-2487048-A1 (CA)
Title: Method for solution based diagnosis
Inventor: RIDDER RUEDIGER
IPC: G01N33/50
Filed: 2003-07-31
Abstract: This invention provides methods for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable fro m the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis fro m dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated wi th the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medicall y relevant condition.
Patent CA-2488387-A1 (CA)
Inventor: EVANS DARIN
IPC: B60R19/18
Filed: 2003-06-06
Abstract: A bumper system includes a bumper beam having a face and ends, and an energy absorber mounted on the face. The energy absorber has a one-piece injection-molded non-foam piece with box sections and interconnecting straps, and a one-piece or multipiece foam component securely insert-molded onto the injection-molded non-foampiece. Different foam can be used to form differently shaped front surfaces on the foam component. By this arrangement, different energy absorbing systems are provided for vehicles, such as to satisfy the need for different styling and shapes, while still using the same non-foam piece. By this arrangement, the energy absorber is a single unit that can be handled and attached to the bumper beam. At the same time, capital investment in molding dies and tooling is reduced.
Patent CA-2489483-A1 (CA)
Inventor: PERAZZO JOHN R
IPC: B65D19/00
Filed: 2002-07-02
Abstract: A pallet (10) includes a number of runners (12) which may be sandwiched between upper and lower deck sheets (16, 18) of corrugated paperboard. Each runner (12) is comprised of multiple layers of corrugated paperboard (36) with the flutes (38) of the corrugations oriented vertically to provide compression strength to the runners (12) and the associated pallet (10). Each runner (12) also may include at least one reinforcing insert (40) most preferably of hardboard to provide beam strength to the runner (12) and a band (35) to avoid failure without a prior indication. Moreover, each runner (12) may include portals (31) which permit four-way entry for the tines (28) of a lift truck and inhibit tipping of the load (14) off the tines (28). As a result, the pallet (10) offers significantly greater safety features, strength and resistence to crushing or compression than known paperboard pallet designs, avoids the significant ecological and economic drawbacks of wooden pallets and can be processed in a paperboard recycling station (44) along with paperboard containers, boxes (48) or the like. Moreover, the system and method for manufacturing the runners (12) with reinforcing inserts (40) overcomes problems of delaminating and separation of the adhesively bonded layers (36, 40) of the runner (12).
Patent CA-2489754-A1 (CA)
Title: Peptides de rupture de feuillets-.beta.
Inventor: SOTO-JARA CLAUDIO
IPC: A61P25/28
Filed: 2003-07-07
Abstract: L'invention concerne des peptides possédant une capacité de rupture de feuillets .beta. et étant utiles dans le traitement et la prévention de maladies, telles que la maladie d'Alzheimer, la démence pugilistique (notamment un traumatisme crânien), l'hémorragie cérébrale héréditaire avec amylose de type hollandais (HCHWA-D) et la démence vasculaire avec angiopathie amyloïde.
Patent CA-2489796-A1 (CA)
Title: Method for tuning an envelope tracking amplification system
Inventor: ANDERSON DALE
IPC: H03F1/02
Filed: 2003-05-05
Abstract: An optimal operating point of an envelope tracking amplification system (100) that includes a radio frequency (RF) power amplifier (110) having an RF  amplifying element (114) is determined based on an application to the RF power amplifier of a supply voltage (211) that is less than the rated voltage of the RF amplifying element.
Patent CA-2492446-A1 (CA)
Inventor: JOHNSON CRAIG L
IPC: C07H13/04
Filed: 2003-07-08
Abstract: La présente invention concerne des procédés de production de composés sous forme d'aminoalkyle glucosaminide phosphate et de disaccharide, ainsi que divers nouveaux intermédiaires et des procédés de production de ces intermédiaires. Selon un aspect, des halogénures de glycosyle sont produits par réaction d'un O-silyle glycoside avec un éther de dihalométhyle alkyle.
Patent CA-2493119-A1 (CA)
Inventor: FITZER-ATTAS CHERYL
IPC: A61K39/00
Filed: 2003-07-16
Abstract: The invention is in the field of immunogenicity. In one embodiment, the invention relates to method of identifying T-cell epitopes in amyloid beta peptide or homologue thereof. In another embodiment, the invention relates to a vaccine comprising an amyloid beta peptide or homologue thereof, whereby the selected peptide is a peptide which lacks certain T-cell epitopes or a peptide which is modified by deleting or modifying amino acids so as to reduce ox eliminate the T-cell epitopes. The selected peptides are further assessed for reduced capacity to form fibrils, reduced cytotoxicity, and a reduced ability to induce a cellular autoimmune response. The selected peptides are further assessed for ability to induce a humoral immune response. In another embodiment, the invention relates to a method of predicting the reaction of an individual to a vaccine, which comprises amyloid beta peptide or homologue thereof, based on the HLA haplotype of the subject. In another embodiment, the invention provides a method for matching a vaccine comprising arnyloid beta peptide or homologue thereof to an individual, based on the HI,A haplotype of that individual. In another embodiment, the invention provides a vaccine comprising an amyloid beta peptide or homologue thereof, whereby the arnyloid beta peptide or homologue thereof, lacks the ability to induce a T-cell response.
Patent CA-2493361-A1 (CA)
Title: Reduced aerosol generating formulations
Inventor: WINETZKY DEBORAH S
IPC: A61K8/86
Filed: 2003-07-23
Abstract: The present invention relates to compositions comprising high molecular weig ht polymers, particularly polyethylene oxide polymers, wherein the high molecul ar weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composition when used in a desired environment. Th e invention further relates to methods of decreasing enzyme exposure from a personal care or cleaning product comprising a high molecular weight polymer .
Patent CA-2494592-A1 (CA)
Title: Security document and verification method
Inventor: SCHERTENLEIB BEAT ROLAND
IPC: B42D15/00
Filed: 2002-07-25
Abstract: A security document, such as a banknote or a cheque, is provided with a perforation pattern (5) having holes (5a, 5b) with elongate cross section.  When viewing the perforation pattern (5) from a direction that is non-perpendicular to the surface of the document, different holes will have different optical transmission, which can be verified by eye or electronically. Perforation patterns (5) of this type are hard to forge and easy to verify.
Patent CA-2495529-A1 (CA)
Title: Noonan syndrome gene
Inventor: TARTAGLIA MARCO
IPC: C12Q1/6883
Filed: 2002-10-01
Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in the protein tyrosine phosphatase gene PTPN11 and its expression product, PTPN11.  Also described are nucleotide sequences, amino acid sequences, probes, and primers related to PTPN11 and PTP11 variants, and cells expressing such variants.
Patent CA-2496436-A1 (CA)
Title: Reinforced substrate for securities
Inventor: MOREAU VINCENT
IPC: B42D15/10
Filed: 2003-09-02
Abstract: The note (1) comprises a substrate having a zone of reduced thickness (2) forming a transparent window in said substrate and reinforcing means (3) to increase the resistance of said zone (2).
Patent CA-2499080-A1 (CA)
Inventor: KOUMANS ROGER G M P
IPC: H01S3/067
Filed: 2003-09-18
Abstract: A linear cavity design to produce a traveling wave operation as in a ring laser without the ring cavity design. All fiber configurations may be used to implement fiber lasers based on the linear cavity design.
Patent CA-2499580-A1 (CA)
Title: Novel agents that modulate eph receptor activity
Inventor: MURAI KEITH K
IPC: C07K14/52
Filed: 2003-08-29
Abstract: Novel agents are described that bind to Eph receptors. Methods of using these agents to modulate the activity of Eph receptors, stimulate apoptosis, and deliver therapeutic agents are also described. Methods of screening for agents capable of selectively binding to Eph receptors are also described.
Patent CA-2499654-A1 (CA)
Inventor: CHEN HSIN-YU
IPC: B65D81/18
Filed: 2005-03-03
Abstract: The present invention discloses a moisture-proof container, comprising a container body and a sealed lid, and the sealed lid is corresponsive to the container body and comprises a sealed cover and an external cover; the sealed cover has a four-tubular pumping pipe and its accessory pump member, and the sealed cover has an air release valve on one side, and an indicator disposed on the other side for expanding or contracting according to the vacuum inside the container.      Reserved holes are disposed on the external cover and corresponsive to the foregoing air release valve and the indicator, such that when the sealed cover and the external cover are coupled, the air release valve and the indicator are exposed from the external cover.
Patent CA-2502342-A1 (CA)
Title: Ruthenium complexes as (pre)catalysts for metathesis reactions
Inventor: GRELA KAROL
IPC: C01G55/00
Filed: 2003-10-10
Abstract: The invention relates to new (pre)catalysts of ruthenium complexes of formul a (I), wherein L1, X, X', R1, R2, R3 and n are defined herein. The novel ruthenium complexes of formula 1 are convenient (pre)catalysts for metathesi s reactions and can be applied i.e. for ring-closing metathesis, cross metathesis or ene-ine metathesis reactions. Another aspect of the invention are the novel intermediates of formula (II).
Patent CA-2503395-A1 (CA)
Title: Method and apparatus for preheating ventilation air for a building
Inventor: HOLLICK JOHN
IPC: F24S10/80
Filed: 2005-04-01
Abstract: An apparatus for pre-heating ventilation air for a building. The apparatus includes a first sunlight-absorbent collector panel on the building. The panel is exposed to ambient air and defines a first air collection space between itself and the building. The first sunlight-absorbent collector panel has a plurality of air inlet openings to allow the ambient air to pass through the openings to the first air collection space. A second sunlight-absorbent collector panel on the building is adjacent the first sunlight-absorbent collector panel and defines a second air collection space between itself and the building. The second sunlight- absorbent collector panel has a plurality of air inlet openings to allow air to pass through the openings to the second air collection space. A glazing covers the second sunlight-absorbent collector panel and defines an intermediary air flow chamber between itself and the second sunlight-absorbent collector panel. The intermediary air flow chamber is in communication with the first air collection space to receive air therefrom. The air inlet openings in the second sunlight-absorbent collector panel provide communication between the intermediary air flow chamber and the second air collection space. An air outlet extends from the second air collection space into the building for air flow therethrough. A fan communicates with the air outlet for moving air from the second air collection space into the building, through the air outlet.
Patent CA-2504791-A1 (CA)
Inventor: STEELE ROBERT E
IPC: B05D3/00
Filed: 2005-04-21
Abstract: The present provides a bondably coated metallic member comprising a metallic member having a low surface energy polymeric coating, said low surface energy polymeric coating having been surface activated on at least a portion thereof, and having on said surface-activated portion a bondable high surface energy polymeric coating. The present invention also provides a bondably-coated metallic pipe comprising metallic pipe having a low surface energy mainline polymeric coating thereon extending over the pipe except at a bare zone adjacent each end of the pipe that is free from said mainline coating; a portion of said mainline coating adjacent each bare zone having been surface activated and having on said surface activated portion a bondable high surface energy polymeric coating.
Patent CA-2505503-A1 (CA)
Title: Procede nano-optique d'estampage en couleur
Inventor: FELLENBERG STEFAN
IPC: B44B5/02
Filed: 2003-11-16
Abstract: L'invention concerne un procédé et un système permettant de produire des couleurs structurales, en particulier sur des structures superficielles métalliques. Le système selon l'invention comprend au moins un dispositif servant à créer des structures réticulaires.
Patent CA-2507025-A1 (CA)
Title: Methods and apparatus for arbitrary antenna phasing in an electronic article surveillance system
Inventor: HERRING RICHARD L
IPC: H01Q7/04
Filed: 2005-05-10
Abstract: A method for controlling electronic article surveillance (EAS) transmissions is described. The method includes calculating system parameters associated with one or more of a desired frequency, a desired duty cycle, and a desired phase difference between antennas for a transmitter, and initializing a counter with a value based on the system parameters. The method also includes comparing a count from the counter to the system parameters, and modulating EAS transmission signals based on the comparison between the count and the system parameters. An EAS transmitter and an EAS system are also described.
Patent CA-2508642-A1 (CA)
Inventor: SZOKE BELA BILL
IPC: B64C25/40
Filed: 2005-06-09
Abstract: This invention is about preventing airplane tires from frequent reconditioning and replacements.     In this invention, we are concerned with planes having wheels on their landing gears.     When the plane lands, the runway's concrete by friction removes the rubber unevenly by the weight of the plane, and the force required to start spinning the wheels.  Each time the plane lands, more rubber is removed unevenly. The touchdown could be at any area of the thread, or the same as it was at the previous touchdown.     The friction removed rubber particles polluting the air. The air-born particles may get into other plane's engines by taxiing or taking off, especially in windy circumstances, when the larger particles are lifted up and sucked into the engines of the plane.     The random locations of excessive wear; create uneven surfaces on the thread of the tire. Require frequent reconditioning and replacement of tires, increasing the cost of the planes operation, ultimately the cost of air travel.
Patent CA-2508658-A1 (CA)
Inventor: MUELLER URS
IPC: C07D239/42
Filed: 2003-12-04
Abstract: L'invention concerne des compositions fongicides représentées par la formule générale (1), dans laquelle W et Y désignent un atome N et X et Z désignent CR?8¿ ou X et Z désignent un atome N et W et Y désignent CR?8 ¿; R?8¿ désigne un atome H, un groupe halo, alkyle en C¿1-4?, alcoxy en C¿1-4? ou haloalkyle en C¿1-4 ?; R et R?2¿ désignent chacun un atome H, un groupe halo, alkyle en C¿1-8?, alcoxy en C¿1-8?, alkylthio en C¿1-8?, alcényl en C¿2-8?, alcynyl en C¿2-8?, cyano ou NR?3¿R?4¿, à condition que R et/ou R?2¿ désigne NR?3¿R?4¿; R?1¿ désigne un groupe halo, alkyle en C¿1-8?, alcényl en C¿2-8?, alcynyl en C¿2-8?, cycloalkyle en C¿3-8?, cycloalkyle en C¿3-8? alkyle en C¿1-6?, alcoxy en C¿1-8?, alkylthio en C¿1-8?, aryle, aryloxy, arylthio, hétéroaryle, hétéroaryloxy, hétéroarylthio, arylalkyle en C¿1-4?, arylalcoxy en C¿1-4?, hétéroarylalkyle en C¿1-4?, hétéroarylalcoxy en C¿1-4?, arylalkylthio en C¿1-4?, hétéroarylalkylthio en C¿1-4?, morpholino, pipéridino ou pyrrolidino.
Patent CA-2509202-A1 (CA)
Inventor: MANTLO NATHAN BRYAN
IPC: C07D277/66
Filed: 2003-12-31
Abstract: La présente invention concerne des composés représentés par la formule structurelle I, dans laquelle (a) X est sélectionné dans le groupe constitué d'un lien simple, O, S. S(O)¿2? et N; (b) U est un lieur aliphatique; (c) Y est sélectionné dans le groupe constitué de C, O, S, NH et d'un lien simple; (d) E est C(R3) (R4)A ou A et (i) A est sélectionné du groupe constitué de carboxyle, tétrazole, alkylnitrile C¿1?-C¿6?, carboxamidek, sulfonamide et acylsulfonamide; (e) B est sélectionné dans le groupe constitué de S, O, C, et N; (f) Z est sélectionné dans le groupe constitué de N et C; à condition que si B est C, Z est N.
Patent CA-2509970-A1 (CA)
Inventor: FOREG CHRISTIAN
IPC: F16L5/02
Filed: 2005-06-15
Abstract: A device for sealing a leadthrough for conduits in a constructional element includes an inherently stiff frame member, and at least one sealing element (12) fixedly secured in the receiving region (17) of the frame member (11) and having an elastic envelope (13), and a connection opening element (15) arranged on the envelope (13) and communicating with its receiving space (16) for effecting filling the receiving space (16) with medium for expanding the sealing element (12) and/or evacuating the receiving space (16) for contracting the sealing element (12).
Patent CA-2509975-A1 (CA)
Inventor: KORAM KWAKU KOI
IPC: G01F23/26
Filed: 2003-12-02
Abstract: A moisture detection system includes an electrical conductor disposed on a surface of a substrate. The electrical conductor has a resonant frequency that varies as a function of an amount of moisture present adjacent the electrical conductor. An oscillator outputs an oscillator signal at a predetermined amplitude and a predetermined frequency. A resonator circuit is coupled to the electrical conductor and is responsive to the oscillator signal and the resonant frequency of the electrical conductor for outputting a resonator signal having an amplitude related to the resonant frequency of the electrical conductor. A filter circuit rectifies and filters the resonator signal and provides it to an analog-to-digital converter which outputs a digital signal related to the rectified and filtered resonator signal. A controller is responsive to the digital signal for causing a system associated with the substrate to operate in accordance with the digital signal.
Patent CA-2510455-A1 (CA)
Title: Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
Inventor: KELLY JEFFREY W
IPC: G01N33/53
Filed: 2003-12-19
Abstract: Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.
Patent CA-2510660-A1 (CA)
Title: Handle assembly for a cleaning apparatus
Inventor: STRASLICKA BRUCE C
IPC: A47L11/34
Filed: 2005-06-23
Abstract: A cleaning apparatus for cleaning a surface in which cleaning solution is dispensed to the surface and substantially simultaneously extracted along with the dirt on the surface in a continuous operation is provided. The cleaning apparatus includes a base portion for movement along the surface and a handle pivotally connected to the base portion. The handle includes a lower portion and an upper portion pivotally connected to the lower portion and pivoted between an upper position for use and a lower position for storage. A solution tank for supplying a flow of cleaning solution to the surface is removably mounted to one of the base portion and the handle. A recovery tank removably mounted to one of the base portion and the handle and is in fluid communication with a suction nozzle secured to said base portion. A suction source is in fluid communication with the suction nozzle for genes acing suction to draw dirt and liquid through the suction nozzle and into the recovery tank, wherein one of the solution tank and the recovery tank is removably mounted to the handle.