baber/WOPTO huggingface dataset:
Patent CA-3081496-A1 (CA)
Inventor: MCCONNELL BRUCE
IPC: A61P25/28
Filed: 2018-11-02
Abstract: The invention relates to a human milk oligosaccharide (HMO) for use in reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity in a human. The invention also relates to a synthetic composition for use, comprising one or more of said HMOs. The invention further relates to a method for reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity by administering at least one HMO and the use of said one or more HMOs in a dietary management of a human.
Patent CA-3082647-A1 (CA)
Inventor: TIMMERMAN BRYAN J
IPC: B23K26/08
Filed: 2020-06-04
Abstract: A laser cutting tool with protective enclosure assembly for manipulating a workpiece on a movable platen includes a frame, a top protection assembly, a middle protection shield, a bottom protection assembly and a laser torch head. The top protection assembly, middle protection assembly, and bottom protection assembly are removably mounted to the frame such that they form a cavity enclosing only substantially the laser torch head.
Patent CA-3085226-A1 (CA)
Inventor: HOLM PEDERSEN THOMAS
IPC: A61K31/192
Filed: 2018-12-14
Abstract: La présente invention concerne des composés appropriés pour le traitement, le soulagement et/ou la prévention de troubles neuromusculaires, comprenant l'inversion du blocage neuromusculaire induit par un médicament. Les composés tels que définis dans la présente invention inhibent de préférence le canal ionique ClC-1.
Patent CA-3085374-A1 (CA)
Title: Compounds for treating and preventing extracellular histone mediated pathologies
Inventor: PARISH CHRISTOPHER
IPC: A61P7/00
Filed: 2018-12-14
Abstract: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of extracellular histones in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating extracellular histone mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of extracellular histone mediated ailments. For example, the present invention relates to methods and uses of ß-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Na), in the therapy of a range of extracellular histone mediated ailments in subjects.
Patent CA-3087109-A1 (CA)
Inventor: MESA PARDILLO CIRCE
IPC: A61K39/00
Filed: 2018-12-17
Abstract: The present invention relates to a pharmaceutical composition with an active principle that includes membrane vesicle conjugates of Neisseria meningitidis and the GM3 ganglioside in a conjugation proportion with a protein excess, with special features regarding the size, surface charge and morphology associated with nanoparticle systems that confer advantageous properties as an immunomodulator, since it induces a convenient and significant reduction of myeloid-derived suppressor cells, with an impact on lymphocyte T response and the survival of tumour patients. The invention further relates to the use of the disclosed pharmaceutical composition for the treatment of cancer, in particular those types of cancer with an increase of myeloid-derived suppressor cells (MDSC); and to a method for treating cancer patients with this composition and to a method for selecting the patients receiving this treatment.
Patent CA-3091145-A1 (CA)
Title: Systemes de capteur
Inventor: DUNN MATTHEW R
IPC: B01F3/08
Filed: 2019-02-15
Abstract: La présente invention concerne des procédés et des compositions permettant une détection améliorée de molécules cibles, par exemple en bio-ingénierie.
Patent CA-3092813-A1 (CA)
Title: Electrochemical sensor
Inventor: PILETSKY SERGEY
IPC: G01N33/543
Filed: 2019-03-12
Abstract: The application provides a method of detecting an analyte in a sample. The method comprises disposing a binding agent in an electrochemical compartment. The binding agent is configured to bind to an interfering species. The method further comprises disposing a solution comprising a sample in the electrochemical compartment. The sample comprises an analyte and the interfering species. The method then comprises applying a voltage across first and second spaced apart electrodes disposed in the solution, and thereby causing a current to flow through the solution between the electrodes. Finally, the method comprises measuring the current and/or voltage and thereby detecting the analyte.
Patent CA-3096391-A1 (CA)
Title: Biomarker for detecting cancer
Inventor: BRESALIER ROBERT
IPC: C07K14/805
Filed: 2019-04-11
Abstract: Methods for detecting colorectal cancer or precancerous conditions such as adenomatous polyps in a subject by detection of a galactose-containing 40-kDa molecule in a serum sample from the subject are provided. Methods for quantifying the amount of a galactose-containing molecule in a serum sample are also provided. The methods can further comprise assaying the sample for the quantity of at least one additional marker to confirm the detection or diagnosis of colorectal cancer using one or more additional quantitative immune- detection assays; the additional marker can be at least one of galectin-3, a peptide derived from galectin-3, carcinoembryonic antigen (CEA), and CYFRA21-1.
Patent CA-3096900-A1 (CA)
Title: Polypeptides having alpha-amylase activity and polynucleotides encoding same
Inventor: NAMOTO TOMOKO
IPC: C12N9/26
Filed: 2019-04-08
Abstract: The present invention relates to a hybrid polypeptide having alpha-amylase activity, selected from a first polypeptide sequence comprising a catalytic core, and a second polypeptide sequence comprising a carbohydrate binding module (CBM), wherein (a) the catalytic core is selected from a polypeptide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to amino acids 20 to 494 of SEQ ID NO: 1 or amino acids 20 to 496 of SEQ ID NO: 1; and (b) the CBM is selected from a polypeptide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and catalytic domains.
Patent CA-3096937-A1 (CA)
Title: Un inhalateur de saveurs
Inventor: MINAMI YUKI
IPC: A24F40/05
Filed: 2019-04-09
Abstract: L'invention porte sur un aspirateur comprenant : un substrat d'élément piézoélectrique comportant un transducteur interdigité (IDT) constitué d'une paire d'électrodes interdigitées ; une section d'alimentation en liquide qui fournit un liquide à atomiser sur une surface du substrat d'élément piézoélectrique sur laquelle est disposée la paire d'électrodes interdigitées ; un capteur qui comprend au moins une paire de sections de détection opposées l'une à l'autre, et détecte le liquide fourni sur la surface du substrat d'élément piézoélectrique ; et une section de commande qui, sur la base du résultat de détection par le capteur, commande la section d'alimentation en liquide de telle sorte qu'une certaine quantité de liquide est fournie sur la surface du substrat d'élément piézoélectrique.
Patent CA-3097988-A1 (CA)
Inventor: KANG SOO-YOUNG
IPC: C08G18/66
Filed: 2019-04-26
Abstract: Provided are hair treatment compositions comprising a polyurethane-urea crosslinked by at least one multi-functional chain extender, and uses thereof.
Patent CA-3098673-A1 (CA)
Inventor: FOLDS RUDY M
IPC: B01F3/04
Filed: 2018-04-26
Abstract: A process for separation of a slurry by radially injecting a stream of a nanogas solution at a shear-focus volume within a pipe; passing an aqueous slurry through the pipe along a direction of flow and through the shear-focus volume; and shearing and/or admixing the slurry with the nanogas solution within the shear-focus volume.
Patent CA-3106996-A1 (CA)
Inventor: MASSEY SCOTT
IPC: A01G31/02
Filed: 2019-07-23
Abstract: A system for providing a growth environment for a plant positioned in an automated plant growing system is disclosed. Light sources with each light source positioned in the automated plant growing system to expose the plant to the light sources and to generate light to trigger photosynthesis in the plant. A controller that monitors a growth parameters associated with the plant to determine whether the growth parameters deviate beyond a corresponding growth threshold. Each of the growth parameters provides an indicator as to a growth status of the plant and the growth status of the plant decreases when the growth parameters deviate beyond the corresponding growth threshold. The controller automatically adjusts an environmental parameter when the growth parameters deviate beyond the growth thresholds. Each of the environmental parameters impact the growth environment of the plant positioned in the automated plant growing system.
Patent CA-3108264-A1 (CA)
Inventor: CHOI JONG-SOO
IPC: A61F5/058
Filed: 2019-08-01
Abstract: This brace for supporting a jaw angle comprises: a mounting portion extending from the middle of the chest and along the pair of collarbones, and supported on the collarbones; at least one elastic supporting portion extending from the mounting portion and upward along at least one side surface of the neck; and a jaw rest portion extending below the mandible from the elastic supporting portion, and supporting the jaw by means of the elastic supporting force of the elastic supporting portion.
Patent CA-3109071-A1 (CA)
Title: Dual land journal bearings for a compound planetary system
Inventor: BRILLON LOUIS
IPC: F01D25/16
Filed: 2021-02-12
Abstract: A journal bearing assembly for rotatably supporting at least one gear, comprising a pin and a journal shaft. The journal shaft includes an inner cavity receiving the pin and an outer surface including a plurality of contact surfaces supporting the at least one gear and at least one annular groove separating adjacent contact surfaces. The pin is configured to support the journal shaft at a support position in the inner cavity.
Patent CA-3110734-A1 (CA)
Title: Bearing assembly of a rotor of a wind turbine and wind turbine
Inventor: ROHRMANN THORSTEN
IPC: F16C33/20
Filed: 2019-08-01
Abstract: A bearing assembly (10) of a rotor (11) of a wind turbine, includes: first and second housing-side axial slide bearing segments (17, 21) which are supported against respective first and second axial sliding surfaces (19, 23) of the rotor (11). Tin axial distance between the axial rotor (11) sliding surfaces (19, 23) against which the axial slide bearing segments (17, 21) are supported defines a bearing length I of the bearing assembly (10). The radial rotor (11) sliding surfaces 27, 30) against which the radial slide bearing segments (25, 28) are supported define a bearing diameter d, and wherein 0.25 V 1 applies to a ratio V = 1/d between the bearing length 1 and the bearing diameter d.
Patent CA-3113446-A1 (CA)
Title: Combination valve
Inventor: DOMINGO FRANCO J
IPC: F16K11/10
Filed: 2021-03-29
Abstract: A valve assembly includes a housing body defining a first opening, a second opening and an internal chamber. A first mechanism is provided in the housing body to control fluid between the first opening and the interior chamber and a second mechanism is provided in the housing body to control fluid between the second opening and the interior chamber. The first and second control mechanisms operate independently.
Patent CA-3114827-A1 (CA)
Inventor: XU JEAN
IPC: C12N5/073
Filed: 2008-07-31
Abstract: Il est décrit des méthodes servant à favoriser la différenciation des cellules souches pluripotentes. Plus particulièrement, il est décrit une méthode améliorée de formation dendoderme pancréatique de cellules qui expriment des hormones pancréatiques et de cellules excrétrices dhormones pancréatiques. Il est également décrit des méthodes servant à favoriser la différenciation de cellules souches pluripotentes sans recours à une couche de cellules nourricières.
Patent CA-3115400-A1 (CA)
Inventor: DYROY ARE
IPC: C25C3/22
Filed: 2019-10-18
Abstract: L'invention concerne un procédé et un équipement de stockage et transport d'éléments émetteurs de gaz chaud, enlevés d'une cellule d'électrolyse destinée à la production d'aluminium, cette cellule étant du type Hall-Héroult comportant des anodes précuites, les éléments comprenant au moins l'un des éléments suivants : anode(s) usée(s), matériau de bain, matériau de revêtement d'anode ; l'équipement comprend un contenant ouvert sur le haut pouvant être fermé, qui peut être fermé au moyen d'au moins un couvercle, ainsi que d'autres moyens destinés à permettre à un matériau d'adsorption de fluorure d'être versé sur au moins l'un de ces éléments qui a été amené dans une chambre centrale (TES) du contenant. L'équipement comprend en outre au moins une aéroglissière de fluidisation (s) disposée à l'extérieur du contenant où le matériau est facilement disponible pour l'au moins une aéroglissière en tant que matériau pré-stocké dans au moins un compartiment de l'équipement ou facilement disponible par fourniture externe de matériau pendant l'opération de recouvrement. L'au moins une aéroglissière distribue le matériau adsorbant le fluorure, par fluidisation du matériau, à travers au moins une ouverture d'entrée (O) dans au moins une paroi latérale (2) du contenant, plus loin dans la chambre centrale (C) et enfin par recouvrement de l'au moins un élément avec le matériau.
Patent CA-3117962-A1 (CA)
Inventor: SINAY AVRAHAM
IPC: A61B1/00
Filed: 2019-10-29
Abstract: The present invention relates to an intubation system comprising an insertion unit to be connected to a bending section of a medical instrument comprising an inner elongated shaft structure being capable of torque transmission around its length axis and an outer elongated shaft structure surrounding the inner elongated shaft structure and having a continuous outer surface, and an orientation controller being attached to the inner elongated shaft, such that when the orientation controller rotates, the bending section turns around itself.
Patent CA-3118417-A1 (CA)
Inventor: DOI YUSUKE
IPC: A61K39/00
Filed: 2019-11-01
Abstract: L'invention concerne une préparation d'émulsion de type eau dans huile (E/H) contenant de façon stable trois types de peptides liés à un épitope à quatre CTL. L'invention concerne également un procédé de préparation efficace de la préparation d'émulsion E/H contenant trois types de peptides liés à un épitope à quatre CTL. La présente invention concerne une préparation d'émulsion E/H contenant de manière stable trois types de peptides liés à un épitope à quatre CTL et concerne également un procédé de préparation efficace de la préparation d'émulsion E/H. L'invention concerne également un procédé et un dispositif améliorés pour préparer la préparation.
Patent CA-3118796-A1 (CA)
Title: Tgf.beta. inhibitor and prodrugs
Inventor: TAURIELLO DANIELE
IPC: A61K31/4709
Filed: 2019-11-22
Abstract: A compound of formula (I) with improved TGFß signaling pathway inhibitory activity, improved therapeutic efficacy and improved toxicity profile, as well as two prodrugs thereof are disclosed. Compositions comprising said TGFß signaling pathway inhibitor and prodrugs thereof are also disclosed. Additionally, present invention discloses said compound of formula (I) and prodrugs thereof for use in a method of treating diseases responsive to TGFß signaling pathway inhibition.
Patent CA-3120394-A1 (CA)
Title: Method of reducing neuronal microtubule binding protein tau (tau) levels
Inventor: CAYOUETTE MICHEL
IPC: C12N15/864
Filed: 2019-12-05
Abstract: There is provided a method of reducing neuronal microtubule binding protein Tau (Tau) levels, promoting neuronal Tau degradation and/or promoting neuronal survival, in a subject in need thereof comprising contacting the subject's neurons with an effective amount of an agent that increases a long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity, whereby neural Tau levels is reduced in the presence of the agent, the neuronal Tau degradation is promoted and/or the neuronal survival is promoted as compared to in the absence thereof. Also provided are methods of stratification based on PTB Numb isoform expression and/or activity of the subjects and compositions and kits for applying the methods.
Patent CA-3122935-A1 (CA)
Inventor: GRAVELLE LISE
IPC: A61K9/10
Filed: 2019-12-18
Abstract: La présente invention concerne une forme amorphe stabilisée d'un composé de formule (I) ainsi que des compositions pour administration orale comprenant le composé de formule (I) dans une quantité thérapeutiquement efficace.
Patent CA-3127472-A1 (CA)
Title: A telescopic ball retrieval device
Inventor: KALFA YONAH
IPC: A63B47/02
Filed: 2020-01-22
Abstract: A ball retrieval device, comprises: a) a telescopic tubing assembly suitable to house a plurality of balls; b) a retrieval mechanism suitable to allow the passage of a ball into said tubing assembly and to prevent its discharge therefrom; c) a positioning element suitable to cooperate with slotted connecting elements and to prevent the undesired rotation of parts of said telescopic tubing assembly relatively to one another; and d) capping element provided with stopping elements, suitable to release balls from the device when said stopping elements are in an open position.
Patent CA-3129379-A1 (CA)
Inventor: PRIM ERIC
IPC: E21B43/40
Filed: 2021-08-30
Abstract: A method for carbon dioxide recycle stream processing with ethylene glycol dehydrating in an enhanced oil recovery process includes receiving a first carbon dioxide recycle stream from a hydrocarbon fomiation, adding ethylene glycol to the first carbon dioxide recycle stream to produce an ethylene glycol and carbon dioxide recycle stream, condensing the ethylene glycol and carbon dioxide stream to produce a multiphase stream, separating the multiphase stream into a water and ethylene glycol stream and a second carbon dioxide recycle stream, separating the water and ethylene glycol stream into a water stream and an ethylene glycol stream, and separating the second carbon dioxide recycle steam into a carbon dioxide reinjection stream and a natural gas liquids stream.
Patent CA-3129946-A1 (CA)
Title: System and method for employing the use of neural networks for the purpose of real-time business intelligence and automation control
Inventor: MCGRATH CHRISTIE PATRICK
IPC: G06Q10/00
Filed: 2010-08-27
Abstract: A system and integration infrastructure to provide a distributed matrix or neural network of connected real-time decision support modules designed to perform business intelligence evaluations in real time. The system and integration infrastructure provide a network of intelligence superimposed upon any company's existing IT data centers and cloud computing connections. The system is highly customizable to the unique business model deployed by the client company within the best practices of the client company's industry.
Patent CA-3130574-A1 (CA)
Title: Electro-hydraulic arrangement for an earthmoving machine
Inventor: FERRAZ JOHN
IPC: E02F9/22
Filed: 2020-02-06
Abstract: An electro-hydraulic arrangement (310) for controlling operation of a pair of tilt actuators (112, 114) of an earthmoving machine (100) includes a housing (312), and a directional control valve (DCV) (314) and a regeneration valve (RV) (316 disposed within the housing (312). The DCV (314) and the RV are coupled in selective fluid communication with one another and with rod end and head end chambers (116, 118) of the actuators via ports defined on the housing (312). When the DCV (314) is in a first or second operative position, the RV may be positioned in a regenerative position to allow the rod end chambers (116) of respective ones of the first and second actuators (112, 114) to communicate fluid to the head end chamber (118) of the second actuator (114). Optionally, the regen valve may be positioned in a drain position to allow the rod end chambers (116) of respective ones of the first and second actuators (112, 114) to communicate fluid with the drain port (346) of the housing (312).
Patent CA-3133301-A1 (CA)
Title: Procede pour delivrer un liquide restant dans un dispositif d'injection enterale ou autre
Inventor: JURETICH JEFFERY T
IPC: F04B49/06
Filed: 2020-03-18
Abstract: L'invention concerne un système de pompage de réduction de déchets et un procédé pour délivrer un liquide à un patient selon un protocole de thérapie prédéterminé, lesquels sont caractérisés par un sous-programme de mode d'évacuation stocké exécutable par un processeur après un arrêt de fin de thérapie d'un mécanisme de pompage, ce par quoi le mécanisme de pompage est actionné de façon à délivrer le liquide résiduel restant dans la tubulure aval d'un ensemble d'administration au patient afin d'empêcher le liquide résiduel d'être gaspillé ou administré manuellement sous un débit non sûr.
Patent CA-3133341-A1 (CA)
Inventor: O'NEILL BRANDON J
IPC: C10G3/00
Filed: 2020-03-03
Abstract: Methods are provided for formulation of catalysts with improved catalyst exposure lifetimes under oxygenate conversion conditions. In various additional aspects, methods are described for performing oxygenate conversion reactions using such catalysts with improved catalyst exposure lifetimes. The catalyst formulation methods can include formulation of oxygenate conversion catalysts with binders that are selected from binders having a surface area of roughly 250 m2/g or less, or 200 m2/g or less. In various aspects, during formulation, a weak base can be added to the zeotype crystals, to the binder material, or to the mixture of the zeotype and the binder. It has been unexpectedly discovered that addition of a weak base, so that the weak base is present in at least one component of the binder mixture prior to formulation, can result in longer catalyst exposure lifetimes under methanol conversion conditions.
Patent CA-3133790-A1 (CA)
Inventor: MATSUMURA YUKI
IPC: H04W72/04
Filed: 2019-03-27
Abstract: This user terminal has: a reception unit that receives downlink shared channels sent from each of a plurality of transmission and reception points; and a control unit that controls the transmission of arrival confirmation signals for the downlink shared channels, on the basis of at least either a count value for DL allocations controlled jointly between the plurality of transmission and reception points or a count value for DL allocations controlled separately between an index for the transmission and reception points and the plurality of transmission and reception points.