baber/WOPTO huggingface dataset:
Patent CA-2337588-A1 (CA)
Title: Oxamides as impdh inhibitors
Inventor: BROADHURST MICHAEL JOHN
IPC: A61P31/04
Filed: 2001-02-20
Abstract: Disclosed are compounds of the general formula   wherein R1 represents heterocyclyl; R2 represents hydrogen, unsubstituted lower alkyl, lower alkoxy, halo, hydroxy or cyano; R3 represents hydrogen, unsubstituted lower alkyl, lower alkoxy, halo, or cyano;  R4 represents hydrogen, lower alkyl, lower cycloalkyl, aryl, or heterocyclyl; R5 represents hydrogen, unsubstituted lower alkyl, lower alkoxy, halo, or cyano; R6 represents hydrogen, unsubstituted lower alkyl, lower alkoxy, halo, or cyano;      R7 represents hydrogen, or unsubstituted lower alkyl;      R8 represents hydrogen, or unsubstituted lower alkyl; or R4 and R8 together with the nitrogen atom to which they are attached represent heterocyclyl; and pharmaceutically acceptable salts thereof. The disclosed oxamide derivatives are inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH). They can be used as medicaments, especially for treating immune mediated conditions or diseases, viral diseases, bacterial diseases, parasitic diseases, inflammation, inflammatory diseases, hyperproliferative vascular diseases, tumours, and cancer. They can be used alone, or in combination with other therapeutically active agents, for example, an immunosuppressant, a chemotherapeutic agent, an anti-viral agent, an antibiotic, an anti-parasitic agent, an anti-inflammatory agent, an anti-fungal agent and/or an anti-vascular hyperproliferation agent.
Patent CA-2339162-A1 (CA)
Title: Electrostatic spray module
Inventor: WHITE ROBERT G
IPC: B05B5/053
Filed: 1999-08-03
Abstract: An electrostatic spray module for applying agricultural liquids such as a pesticide to crops where, externally to the spray module the number of connections is reduced to three, one for the liquid pesticide, one for compressed air and one for a low voltage signal. Internally to the spray module, the low voltage is converted to a high voltage signal, which is, along with the pesticide and the compressed air delivered to one or more electrostatic spray nozzles using only two electrically conductive pipes, a gas delivery pipe and a liquid delivery pipe. The nozzles fit into the gas delivery pipe and draw the compressed air through gas channel openings in the side of the nozzles.      The gas delivery pipe doubles as the means to delivery the high voltage signal to the nozzles. Each nozzle has a liquid feed from the liquid delivery pipe, which carries ground voltage, maintaining the liquid at ground voltage. The grounded liquid merges with the compressed air in the nozzles to form an atomized liquid. The atomized liquid then passes through an electrode, which is electrically charged by the high voltage signal to form an electrostatic spray. The electrical charge in the spray leads to better dispersal of the spray due to the droplets in the spray repelling from each other, and further improves the adherence of the spray to crops which attract the charged droplets.
Patent CA-2339846-A1 (CA)
Inventor: SPIRIDIGLIOZZI JOHN
IPC: A61F6/22
Filed: 1999-08-13
Abstract: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system (10) configured to deliver two or more fluent pre-polymer solutions without premature cross-linking. The delivery system (10) comprises separate first and second lumens (23, 24) coupling first, and second inlet ports (14, 15), first and second outlet ports (16, 17), respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods, and apparatus are also described.
Patent CA-2344187-A1 (CA)
Inventor: O'SULLIVAN PAUL FINTAN
IPC: A61B5/00
Filed: 1999-09-20
Abstract: Sensors and sensing apparatus are described, based on fused tapered fibre optic couplers with the taper waist portion formed into a loop or cleaved to provide a reflecting end. Light is typically input to the taper waist portion along a single input fibre, and bending of the loop or cleaved taper waist portion causes changes in the coupling ratio between the ouput fibres. The taper waist portion may be formed into a loop with a small bend radius without loss, and sensors embodying the claimed invention are particularly suitable for in-vivo measurement of pressure, the taper waist portions advantageously being arranged in contact with a membrane which deflects according to surrounding pressure. Further embodiments are described which are suitable for measurement of fluid flow velocity and/or acceleration.
Patent CA-2345688-A1 (CA)
Inventor: GRAWROCK DAVID
IPC: G06F1/00
Filed: 1999-09-21
Abstract: In accordance with the invention a method of securely and automatically authenticating a user is disclosed. Bona fides are entered for a user, hashed, and stored at an authenticating entity, remote from the user's computer. When a user forgets his/her password, the user enters his/her bona fides, which are again hashed on the user's system, and then securely transmitted to the authenticating entity. The authenticating entity compares the received, hashed bona fides to those previously stored at the authenticating entity. If the comparison shows that the values match or otherwise appropriately correlate, the user will be authenticated. The user will then be provided with the means to access his/her encrypted data. In other words, once authenticated the authenticating entity will automatically provide the user and/or the user's computer with an access key, in one embodiment, allowing the user to access his/her encrypted data.
Patent CA-2347457-A1 (CA)
Title: Devices and methods for use in performing transmyocardial coronary bypass
Inventor: LAROYA GILBERT S
IPC: A61F2/06
Filed: 1999-10-12
Abstract: This invention is a trans-myocardial bypass device including retractors (R) used to engage, to support myocardial tissue, and mechanisms (100) for supporting coronary vessels so as to allow precise entry into a vessel lumen.  Conduits (240) are provided having a configuration that permits positioning in a heart wall to place a coronary vessel in communication with a heart chamber.
Patent CA-2349163-A1 (CA)
Title: Lighting system for mass-transit vehicles
Inventor: DOMAS BEN V
IPC: B60Q3/02
Filed: 1999-11-23
Abstract: A lighting system (20, 20') for preferentially illuminating the seating area (38) of a mass-transit vehicle (22) includes a light fixture (42) with a lamp housing (52) longitudinally disposed above the seating area (38). An electrically energized light source (74) is mounted at at least one end of the light fixture (42). At least one solid-core semi-rigid light pipe (76, 78, 80) extends from and is optically coupled to the light source (74). The light pipe (76, 78, 80) receives light from the light source (74), transmits the light along its length, and emits the light laterally into the passenger compartment (24). The light pipe (76, 78, 80) runs parallel to and is suspended from the lamp housing (52) between the lamp housing (52) and the seating area (38) so that the lamp housing (52) can direct laterally emitted light from the pipe (76, 78, 80) into the seating area (38). The light pipe (76, 78, 80) can be supported by a hanger device (92). Additionally, the light source (74) can comprise a dual-port light source (74k).
Patent CA-2354107-A1 (CA)
Title: Compositions a application topique comprenant des hydroxystilbenes glucosyles et utilisations
Inventor: MEHUL BRUNO
IPC: A61P43/00
Filed: 2001-07-25
Abstract: La présente invention est relative à des compositions appropriées pour l'application topique comprenant des hydroxystilbènes glucosylés. Elle porte aussi sur un procédé de libération progressive des hydroxystilbènes au niveau du stratum corneum, par l'application d'une composition comprenant des hydroxystilbènes glucosylés comme précurseur. Elle porte enfin sur l'utilisation des hydroxystilbènes glucosylés pour lutter contre l es signes du vieillissement cutané et du follicule pileux, pour améliorer l'écl at du teint, pour lisser la peau du visage, pour traiter ou prévenir les rides et les ridules de la peau ou pour stimuler le processus de renouvellement épidermique.
Patent CA-2355596-A1 (CA)
Title: Dark-current compensation circuit
Inventor: THOMAS BRENT D
IPC: H04N5/361
Filed: 1999-12-29
Abstract: An imaging device includes a compensation circuit for reducing an effect of dark current generated during operation. The compensation circuit calculates  an initial dark current offset value using optically dark regions of a photo  sensitive array. The compensation circuit also automatically adjusts the initial dark current offset value as output signals from successive rows of the photo sensitive array are transferred. The compensation circuit can calculate the initial dark current offset value each time an image is captured, thereby compensating for variables such as temperature.
Patent CA-2356051-A1 (CA)
Inventor: MORII TOSHIYUKI
IPC: G10L19/12
Filed: 1997-11-06
Abstract: A random code vector reading section and a random codebook of a conventional CELP type speech coder/decoder are respectively replaced with an oscillator for outputting different vector streams in accordance with values of input seeds, and a seed storage section for storing a plurality of seeds. This makes it unnecessary to store fixed vectors as they are in a fixed codebook (ROM), thereby considerably reducing the memory capacity.
Patent CA-2358959-A1 (CA)
Inventor: MAUSSER HELMUT
IPC: G06Q40/06
Filed: 2000-11-24
Abstract: La présente invention concerne un système et un procédé d'évaluation d'un portefeuille d'après ses performances par rapport à un point de référence spécifique et selon plusieurs scénarios à venir. Plus particulièrement, l'invention permet de prendre un portefeuille et de calculer deux valeurs liées à ce portefeuille, la première valeur correspondant à la baisse potentielle de la valeur du portefeuille en dessous d'une valeur de référence, au cours d'un horizon donné, et une seconde valeur correspondant à une somme dont la valeur du portefeuille pourrait dépasser une valeur de référence, au cours d'un horizon donné, en prévision de plusieurs scénarios différents à venir. L'invention porte également sur des moyens permettant de déterminer le portefeuille permettant d'obtenir le compromis optimal entre ces deux valeurs, et d'évaluer des mesures des performances risques/récompenses grâce à ces deux valeurs qui peuvent s'utiliser pour classer des instruments, des valeurs ou des portefeuilles. L'invention concerne en outre des moyens permettant de fixer un prix d'assurance de portefeuille pour des portefeuilles optimaux.
Patent CA-2360730-A1 (CA)
Title: Human liver progenitors
Inventor: REID LOLA M
IPC: A61P1/16
Filed: 2000-01-19
Abstract: Methods of isolating and cryopreserving progenitors from human liver are disclosed which include processing human liver tissue to provide a substantially single cell suspension comprising progenitors and non-progenitors of one or more cell lineages found in human liver; subjecting the suspension to a debulking step, which reduces substantially the mumber of non-progenitors in the suspension, and which provides a debulked suspension enriched in progenitors exhibiting one or more markers associated with at least one of the one or more cell lineages; and selecting from said debulked suspension those cells, which themselves, their progeny, or more mature forms thereof expess one or more markers associated with at least one of the one or more cell lineages. Among these markers are CD14, CD34, CD38, CD45, and ICAM.  Hepatic progenitors are characterized as being 6-15 µ in diameter, diploid, glycophorin A-, CD45-, AFP+++, ALB+, ICAM+ and with subpopulations varying in expression of CD 14+, CD34++, CD38++, CD117+. These progenitor subpopulations have characteristics expected for cells that are particularly useful in liver cell and gene therapies and for extablishing bioartificial organs.
Patent CA-2360776-A1 (CA)
Inventor: PEET MALCOLM
IPC: A61P25/28
Filed: 2000-01-21
Abstract: A pharmaceutical preparation comprising EPA in an appropriately assimilable form, for example in the form of the ehtyl ester, where of all the fatty acids present in the preparation at least 90 %, and preferably at least 95 %, is in the form of EPA and where less than 5 %, and preferably less than 3 %, is in the form of DHA  is provided for the treatment of a psychiatric or central nervous disorder. The preparation may be administered with conventional drugs to treat psychiatric or central nervous disorders, like schizophrenia, bipolar disorders, attention deficit, hyperactivity disorder, dementia, panic and anxiety disorders.
Patent CA-2361668-A1 (CA)
Inventor: GANNE JEAN-PIERRE
IPC: H03B5/18
Filed: 2000-02-04
Abstract: The invention concerns an oscillator comprising a dielectric resonator (1), coupled to a load impedance (2) through an amplifying active element (3). The dielectric resonator (1) consists of a ceramic material (4) with ferroelectric properties arranged between two metallised surfaces (5, 6) and polarised by an electric field generated by a difference of potential applied between the two surfaces (5, 6) depending of the tuning frequency of the oscillator. The invention is applicable to radio transmitters/receivers.
Patent CA-2362485-A1 (CA)
Inventor: AHL PATRICK
IPC: A61K9/133
Filed: 2000-03-01
Abstract: This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agent s in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.< /SDOAB>
Patent CA-2363738-A1 (CA)
Inventor: JEAN RICHARD
IPC: E04B9/34
Filed: 2001-11-26
Abstract: A construction element having a card like structure and which can be used to build three dimensional structures, the construction element having upper and lower marginal edges, side marginal edges, first and second upper tabs, first and second lower tabs, and a upper recess formed in an upper marginal edge and a lower recess formed in a lower marginal edge, the lower recesses being designed to receive the lower tabs and upper recesses being designed to receive the upper tabs.
Patent CA-2363964-A1 (CA)
Title: Moniker method, apparatus, system and article of manufacture
Inventor: LAEMMLE BEAT
IPC: G06F9/445
Filed: 2000-02-22
Abstract: A moniker is provided that accesses already-running instances of objects that do not have a resistant state. In one aspect, the objects are associated with a programmable logic controller (PLC). The PLC may be a soft PLC that interfaces with a personal computer. A remote connection is provided for such that the moniker instantiates objects of PLCs remotely such as over the internet.
Patent CA-2364431-A1 (CA)
Title: Couches de tamis moleculaires cristallins et leur procede de fabrication
Inventor: LAI WENYIH F
IPC: B01J37/02
Filed: 2000-03-10
Abstract: La présente invention concerne un procédé de fabrication de couches de tamis cristallins présentant une bonne sélectivité de paraxylène par rapport au métaxylène et une bonne perméance pour le paraxylène. Dans ce procédé, il est nécessaire d'imprégner le support avant la synthèse hydrothermale au moyen du procédé d'ensemencement, ou alors avec le masquage à préimprégnation. La couche de tamis moléculaire cristallin présente une sélectivité (.alpha.¿x?) de paraxylène par rapport au métaxylène d'au moins 2, et une perméance (Q¿x?) pour le paraxylène d'au moins 3,27 x 10?-8¿ mole(px)/m?2¿.s.Pa(px), mesurée à une température de >=250 ·C et une pression partielle d'hydrocarbures aromatiques >=10 x 10?3¿Pa.
Patent CA-2365008-A1 (CA)
Inventor: VEERMAN JOHANNES MICHAEL MARIA
IPC: C10G11/18
Filed: 2000-02-22
Abstract: L'invention concerne un appareil destiné à séparer les particules solides d'une suspension de particules solides et de gaz, l'appareil comprenant ce qui suit: (i) une cuve cyclone verticale primaire comportant un récipient tubulaire constitué d'une partie de paroi tubulaire munie d'une entrée tangentielle destinée à recevoir la suspension et d'un couvercle obturant l'extrémité supérieure de la partie de paroi tubulaire, le couvercle comportant une ouverture axiale circulaire servant d'ouverture d'admission de gaz d'une conduite d'évacuation de gaz; (ii) un ou plusieurs séparateurs cyclones gaz / solides en communication fluidique avec la conduite d'évacuation de gaz du cyclone primaire.
Patent CA-2365867-A1 (CA)
Inventor: FAHRER ALWIN
IPC: B29C65/00
Filed: 2000-03-02
Abstract: An electrofusion coupler (14) suitable for joining the end of one reinforced thermoplastic pipe (12) to the adjacent and substantially axially aligned end of another reinforced thermoplastic pipe (10), the electrofusion coupler (14) comprising an annular body to surround the adjacent ends of the pipes to be joined and heating means to weld the inside surface of the annular body of the coupler to the plastics material of the outside surfaces of the pipes, wherein the coupler (14) is provided with axial reinforcement.
Patent CA-2367284-A1 (CA)
Title: Monitoring device for a working vehicle
Inventor: BISCHOFF LUTZ
IPC: A01D41/127
Filed: 2002-01-08
Abstract: A monitoring device for monitoring the function of an agricultural working machine comprises at least one sensor that is designed for generating a sensed signal containing information on noise caused by at least one movable element of the working machine. A computer receives the sensed signal of the sensor and generates an output signal value based on the sensed signal delivered by the sensor and a comparative value. Defect messages can be generated to alert the operator of a defect condition.
Patent CA-2368603-A1 (CA)
Inventor: PALVOELGYI SANDOR
IPC: B60K15/03
Filed: 2002-01-18
Abstract: A fuel tank with an opening, on which a lid is mounted in a removable manner by means of thread or bayonet, is intended to provide a sustained and sealed closure under all conditions. For this purpose, two sealing rings are arranged between the sealing surfaces, the inner one being liquid-tight and the outer one being made of an elastomer with high permeation resistance. The sealing surfaces within the outer sealing ring have a narrow gap leading as far as the outer sealing ring, and the fuel tank has a reinforcement surrounding the opening.
Patent CA-2368703-A1 (CA)
Title: Substituted aniline compounds
Inventor: PUHL MICHAEL
IPC: C07C237/30
Filed: 2000-03-31
Abstract: The invention relates to substituted aniline compounds of formula (1), where in R21, R22 and R23 have the meanings cited in the description. The inventive compounds are intermediate products used producing herbicidally active pyridine dicarboxylic acid amide compounds.
Patent CA-2368942-A1 (CA)
Inventor: GONG XIAO-YAN
IPC: A61F2/24
Filed: 2000-04-17
Abstract: A heart valve is disclosed which includes a valve body and a plurality of flexible leaflets coupled to the valve body. The plurality of leaflets has an open position and a closed position. Each of the plurality of leaflets comprises a belly when the plurality of leaflets are in their respective closed positions. The belly of one or more of the plurality of leaflets has a continuous curvature except for a non-continuous portion.
Patent CA-2369297-A1 (CA)
Title: A hand-piece for injection device with a retractable and rotating needle
Inventor: PETTINATO DAVID
IPC: B01J19/00
Filed: 2000-05-05
Abstract: An injection device is arranged, and constructed to simultaneously rotate a needle (22) during its forward translation as a therapeutic agent such as a liquid is ejected therefrom. In one embodiment the injection device is an automatic device including a pump (12) forcing the liquid through a tube (18 ) to a hand-piece (20), a second position in which the needle (22) extends outwardly of the hand-piece (20) so that it can be used to eject the liquid,  with the needle (22) being automatically uni-directionally or bi-directional ly rotated as it is advanced between the first, and second positions. In an alternate position a syringe (100) is provided with a barrel (102), a plunge r (112) extending into the barrel (102) by the operator. The needle (22), and plunger (112) are arranged so that as the plunger (112) enters the barrel (102) forcing the liquid to be expelled, the needle (22) automatically rotat es about its axis at the same time.
Patent CA-2373612-A1 (CA)
Title: Application device for highlighting hair
Inventor: HOFFKES HORST
IPC: A45D19/02
Filed: 2000-05-06
Abstract: The invention relates to an application device which is configured in such a way that said device can be mounted on the opening of a container that receives or contains hair dyeing agents. The cap (1) is provided with at least one outlet (13). At least one guiding device (6) for the product and at least one guiding prong (10) which is adjacent thereto and can be re-moved are provided. The guiding prong (10) is essentially designed in a strip-shaped manner.  Said prong (10) is at least twice as large as the inside diameter of the guiding device (6) for the product. Application properties have been significantly improved.
Patent CA-2374155-A1 (CA)
Title: A detection method of protein-protein interaction
Inventor: OTAKE MIYAKO
IPC: C07K14/47
Filed: 2001-03-13
Abstract: A method of detecting an interaction between a protein X and a protein Y having a reporter function in eucaryotic cells, characterized by comprising modifying the protein X and/or the protein Y so that the proteins X and Y ar e expressed in cells in different localization patterns, co-expressing the proteins X and Y in eucaryotic cells, and then specifying the intracellar localization of the protein Y by using the reporter function as an indicatio n; and a method of detecting the inhibiting or promoting effect of a compound Z  on the interaction of the proteins X and Y in eucaryotic cells.
Patent CA-2377105-A1 (CA)
Title: Structure reticulee synthetique thermoretractable
Inventor: MOORE DONAL
IPC: D03D15/567
Filed: 2000-06-30
Abstract: L'invention concerne une structure réticulée (10) formée à partir d'un ensemble de fils de chaîne (12) et d'un ensemble de fils de trame (14). Les fils de chaîne sont fabriqués à partir d'une matière synthétique à mailles se rétractant lorsqu'elle est exposée à la chaleur. Les fils de trame traversent l'armure des fils de chaîne aux noeuds d'intersection des fils simples. On applique de la chaleur à la structure réticulée de sorte que l'armure des fils de chaîne se rétracte de manière étroite autour des fils de trame à l'emplacement des noeuds, ce qui permet de rassembler à la fois les fils de trame et les fils de chaîne pour former une maille présentant une résistance élevée.
Patent CA-2378036-A1 (CA)
Inventor: DUNCAN DANA B
IPC: G06Q30/06
Filed: 2000-07-06
Abstract: La présente invention concerne un procédé destiné à des transactions commerciales via un réseau entre plusieurs acheteurs (1105) et vendeurs (1103). A titre d'exemple, dans un mode de réalisation, ces transactions ont lieu dans un système extranet amélioré qui est un réseau sécurisé à accès limité opérant dans le réseau public à commutation par paquets (Internet) et permettant seulement aux acheteurs et aux vendeurs d'accéder au site web alors que cet extranet communique avec des systèmes de crédit, de facturation, de collecte d'informations, de chambre de compensation (1109), d'assurances, de transport, de recherche et bancaire, et en tire avantage. La base de données interactive (1107) contient des informations en temps réel en rapport avec une transaction, au cours de laquelle l'acheteur soumet une demande pour un produit et cette demande réserve ce produit qui ne peut donc plus être choisi par un autre client.