Patent KR-20030029894-A (KR)
Title: 포유동물 세포 배양물을 이용하여 인간의 트롬보포에틴폴리펩타이드를 제조하는 방법
IPC: C12N15/63
Filed: 2001-08-23
Abstract: 시험관내 배양물에서 포유동물 세포에 의해 생물학적 활성인 인간 TPO를 생산하는 방법을 개시한다. 면역글로블린 인헨서에 결합된 면역글로불린 프로모터를 포함하는 DNA 작제물을 통해 인간 트롬보포에틴 유전자를 도입시켜 뮤린의 골수종 세포를 유전자 변형시킨다. 그 결과 수득되는 hTPO는 시험관내 및 생체내에서 거대핵 계열의 조혈 세포의 증식이나 발생을 자극하는 방법에 유용하다. 
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