baber/WOPTO huggingface dataset:
Patent KR-940000451-B1 (KR)
Title: Noise-reducing circuit
Inventor: KIM KYONG-UK
IPC: H04M1/00
Filed: 1991-03-12
Granted: 1994-01-21
Abstract: The noise reducing circuit for a subscriber line interface includes a hook-on detector for obtaining the absolute value of the current difference between output signals output by a subscriber telephone to telephone lines and detecting the hook on of the subscriber telephone with the magnitude of the absolute value, and a gain controller for controlling the amplified gain of a differential amplifier according to the output of the hook-on detector, thereby simplifying the configuration of circuit.
Patent KR-940011553-B1 (KR)
Title: Method of controlling steam pressure in tableware washing machine
Inventor: KIM HWA-JUNG
IPC: A47L15/00
Filed: 1991-05-20
Granted: 1994-12-21
Abstract: In a dish washer proceeding with the cleaning work through a spray nozzle by supplying hot/cold water, the discharging of steam pressure in a washing tub of a dish washer includes the steps of: sensing a temperature of the cleaning water supplied to the cleaning tub by a temperature sensor; proceeding with the cleaning work by the MICOM according to the sensing signal from the temperature sensor by periodically turning on/off the motor of a cleaning pump, thereby giving times for discharging the steam pressure generated during the cleaning work to the steam discharging hole.
Patent KR-930006107-B1 (KR)
Title: Regulator shield device of intermediate frequency printed circuit board
Inventor: PARK U-JIN
IPC: H05K9/00
Filed: 1991-05-30
Granted: 1993-07-07
Abstract: The device removes regeneration generated  from  interference between the PCB and the regulator and  improves  voltage  standing wave ratio by mounting a cap-type shield  cover  on  the  PCB  and fastening a projected section on the regulator  by  screw-driving. The device comprises two legs (3a)(3b) projected from shield cover body (2) and inserted in to two holes (7a)(7b) on PCB (6); stepped section (4) having a screw hole (5) and fastened with a  hole  (9) on the regulator side by screw-driving.
Patent KR-940002241-B1 (KR)
Title: Video signal test circuit
Inventor: LEE HANG-YUN
IPC: H04N17/00
Filed: 1991-08-14
Granted: 1994-03-19
Abstract: The image processing tester includes a sync separator, an A/D converter, first to sixth input buffers, an oscillator, an address generator for generating first and second address signals, a counter for sequentially enabling the first to sixth input buffers, first to sixth memories for storing and outputting an A/D converted video signal, a frequency divider for generating first and second enable signals, and first to sixth buffers for latching the signals output from the first to sixth memories, thereby facilitating the checking of a signal processor.
Patent KR-100210889-B1 (KR)
Inventor: JANERIC WOODENPELD
IPC: H04B7/26
Filed: 1991-09-06
Granted: 1999-07-15
Abstract: 본 발명은 이동 무선국에서 이동 무선 시스템 내의 다수의 기지국 B1 내지 B2로부터 전송되는 다수의 전용제어 채널 DCCH1 내지 DCCH21 중 1개의 채널을 선택하기 위한 방법에 관한 것이다.  상기 이동국 내에는 상기 이동국과 소정의 기지국 사이의 무선 매체의 다중경로 전달 특성을 보상하기 위한 이퀄라이저가 있다.  이 이퀄라이저는 전력을 소비하므로 필요치 않은 경우에는 사용되지 않는다.  이 방법에 따라 이퀄라이저가 이동국으로부터 기지국으로의 호출 초기화 중에 단선될 수 있는지의 여부에 대한 조사가 이동국에서 수행된다.  최고의 신호 세기를 갖는 전용 채널 DCCH1의 신호질은 이퀄라이저 없이 측정된다.  이 신호질이 허용될 수 없는 경우에 새로운 검출이 이퀄라이저를 사용하여 행해진다.  그 다음, 신호질이 허용될 수 있는 경우에, 다른 검출이 다음의 최고의 신호 세기를 갖는 전용 제어 채널 DCCH2 상에서 이퀄라이저 없이 행해지고 이 검출이 허용가능한 신호질을 나타내는 경우에 이 제어 채널을 전송하는 기지국 B2는 다른 호출 진행을 위해 이동국에 의해 선택된다.
Patent KR-950013778-B1 (KR)
Inventor: BUDRIS ALLAN ROGER
IPC: H02K23/66
Filed: 1991-10-28
Granted: 1995-11-16
Abstract: 내용 없음.
Patent KR-940005610-B1 (KR)
Title: Method of making memory apparatus in the semiconductor
Inventor: JANG SONG-NAM
IPC: G03F7/00
Filed: 1991-10-29
Granted: 1994-06-21
Abstract: The method comprises the steps of sequentially forming a gate oxide layer, gate electron layer, gate insulating layer and etch stop on a silicon substrate, forming interlevel insulating layer on the substrate, forming a predetermined photoresist 1 on the substrate, forming a contact hole through photolithography, carrying out etching using a resist pattern to expose an active region, thereby improving reliability and yield.
Patent KR-100220257-B1 (KR)
Title: Preparation of melt-processable acrylonitrile/methacrylonitrile copolymers
Inventor: BENEDICT S CURATOLO
IPC: C08F220/44
Filed: 1991-12-21
Granted: 1999-09-15
Abstract: A process for forming a stable and processable polymer comprised of methacrylonitrile (10 to 80 percent) and acrylonitrile (20 to 90 percent) by controlling the ratio of the monomers in the reaction mixture.
Patent KR-940008320-B1 (KR)
Title: Manufacturing method of semiconductor device
Inventor: KIM YONG-BAE
IPC: H01L21/76
Filed: 1991-12-28
Granted: 1994-09-12
Abstract: The method improves the process of producing device separation region during manufacturing semiconductor devices by: (A) forming oxynitride (12), silicon nitride (13), and oxide films (14) on silicon substrate; (B) removing the oxide film selectively by lithography; (C) forming again the oxide film (15) by CVD; (D) removing nitride film and silicon substrate (11) at the opening site and all oxide films by reactive ion etch; (E) forming oxide layer (17) by thermal oxidation; and (F) removing oxynitride and nitride films from the surface. The method has advantages in lowering the negative angle of the field oxide layer, lengthening the effective separation distance, and flatening the top surface of the separation region.
Patent KR-940005859-B1 (KR)
Title: Fluorescent display tube
Inventor: KYE DONG-HUN
IPC: H01J31/15
Filed: 1991-12-30
Granted: 1994-06-24
Abstract: By removing the cause of gas generation from an electrostatic shielding layer, this tube provides an improved luminance. If a fixed voltage is supplied to a line cathode (15) and an electrostatic shielding layer (13), thermoelectrons emit and a grid (14) focuses and accelerates them, so that they land at an electrostatic shielding layer to generate luminesce from the fluorescence layer. At this point the electrostatic shielding layer absorbs the emitted electron beam and doesn't let the beam reflect. So this tube prevents an electrostatic shielding layer from decreasing the luminance. The electrostatic shielding layer laminates an insulation layer (21) which comprises SiO2 and black dyes, and transparent conductive layer (11) on a rear board (17) in order.
Patent KR-0153433-B1 (KR)
Inventor: HAN JONG-HE
IPC: H04N5/445
Filed: 1992-02-13
Granted: 1998-11-16
Abstract: 채널 기억 장치를 구비한 C/TV 및 VCT에 있어서, 기억된 전 채널과 방송국명을 일시에 CRT에 표시시킴으로써 방송국에 따른 채널을 파악할 수 있도록 한 것으로 종래에는 채널 선택에 따른 채널과 방송국명만을 표시되었었다. 
     즉 리모콘 송신기(10) 및 콘트롤러(20)에 기억된 전 채널과 방송국명을 표시시키는 채널 표시키를 형성시키고, 
     상기 리모콘 송신기(10) 및 콘트롤러(20)의 채널 표시키 입력으로 마이콤(30)에서는 OSD 회로(50)로 마이콤(30) 내에 기억된 전 채널과 방송국명의 OSD 데이타를 출력시키며 
     상기 OSD 데이타가 인가된 OSD 회로(50)는 OSD 데이타로 동작하여 CRT상에 전 채널과 방송국명을 일정시간 동안 표시시킴으로써 사용자가 방송국에 따른 채널을 쉽게 파악할 수 있다.
Patent KR-940010104-B1 (KR)
Title: Plural form of electrolytic cell
Inventor: MUN SANG-BONG
IPC: C25B9/00
Filed: 1992-03-05
Granted: 1994-10-21
Abstract: The electrode cell that can reduce cost and operation time for construction and diassembling of bath by separated wall of double electrode without explosive weld inside electrolytic chamber, is characterized by the electroconductive plate of multistage to maintain uniformly current density and concentration of electrolyte, and sloped frame wall to protect cation exchange membrane from Cl2 gas.
Patent KR-950000152-B1 (KR)
Title: Manufacturing method of gate overlap ldd cmos
Inventor: KIM CHON-SU
IPC: H01L27/092
Filed: 1992-03-17
Granted: 1995-01-10
Abstract: forming a sacrifice gate region on the substrate (1) by using a silicon nitride film (7) and a silicon oxide film (2); implanting impurities thereinto to form an LDD n- region (13) and an LDD p- region (12) to form a spacer (14) on the side wall of the gate region; forming an etching a silicon oxide film (17) thereonto by using a lapping method; etching the poly-Si (11), the film (10) and the spacer (14) to form a gate frame and filling the gate frame with a poly-Si layer to form a gate with a lapping method; thereby obtaining a fully gate overlapped LDD structure.
Patent KR-100253561-B1 (KR)
Title: Method of depositing w on oxide of semiconductor device without adhesion layer
Inventor: LEE HYUN-CHUL
IPC: H01L21/3205
Filed: 1992-08-28
Granted: 2000-05-01
Abstract: PURPOSE: A method for depositing tungsten on a surface of an oxide film in a semiconductor device is provided to enable a tungsten layer to be grown on a surface of an oxide film without using an adhesive layer. CONSTITUTION: After an oxide film(1) is deposited on a substrate, the oxide film(1) is etched for a predetermined time by a reactive ion etching method. Thus, the coupling energy of Si-O in the surface of the oxide film(1) becomes weakened. At this time, by providing gases such as CHF3 or CF4, seeds for coupling with tungsten layer are formed on the surface of the oxide film(1). Alternatively, after the oxide film(1) is deposited on the substrate, seeds can be formed on the oxide film by an ion implanting method.
Patent KR-970000835-B1 (KR)
Inventor: OKAJIMA HIROYUKI
IPC: G02F1/1335
Filed: 1992-09-01
Granted: 1997-01-20
Abstract: 내용 없음.
Patent KR-950004069-B1 (KR)
Title: Manufacturing method of rayon-type mixing yarn
Inventor: SO WON
IPC: D02G1/16
Filed: 1992-11-05
Granted: 1995-04-25
Abstract: The method is characterized by a fluid interface by which copolymer polyester yarn of a high contractibility and a low specific gravity is mix spinned with another polyester yarn of a low contractibility and a high specific gravity.
Patent KR-0132410-B1 (KR)
Inventor: KIM KYUNG-JOON
IPC: H02M1/32
Filed: 1992-11-19
Granted: 1998-04-20
Abstract: 본 발명은 전자기기에 동작전압을 공급하는 전원회로, 특히 두 개의  전압(예로, 110V/220V)을 겸용으로 사용하는 전자기기의 전원회로에서 전원 오접속 방지방법 및 그 장치에 관한 것으로서, 두 레벨의 전압을 절환스위치에 의하여 선택 입력하여 직류로 변환하는 직류 전압발생부와, 상기 직류 전압의 크기를 검출하는 전압검출부와, 경보음발생부와, 상기 직류 전압의 접속 경로를 차단하는 전원차단부와, 전원차단부를 통하여  직류 전압을 인가받아 일정 크기로 정형하는 레귤레이터를 구비하여, 전압 검출부에서 검출되는 전압이 정상상태로 벗어날 때에는 전원차단회로를 동작하여 전원을 차단하고, 동시에 경보음 발생부를 동작하여 경보음을  발생함을 특징으로 한다.
Patent KR-100230770-B1 (KR)
Inventor: YOU DAE WOON
IPC: G06F13/00
Filed: 1992-11-21
Granted: 1999-11-15
Abstract: 본 발명은 에스씨에스아이(SCSI : Small Computer System Interface, 이하 SCSI라 칭한다)에서의 아비트래이션(arbitration)에 관한 것으로, 일반적으로 사용되고 있는 SCSI 버스 중재회로는 자신의 ID에 따른 데이타 라인을 "하이"로 드라이브함으로써 이루어지므로 결국은 8개의 SCSI 디바이스들이 ID에 의해 우선순위가 결정된 상태로 이루어지며, 아비트래이션 방식이 패리티 방식으로 고정되어 있어서 최대 8개의 SCSI 디바이스들이 공평하게 SCSI를 사용할 수 없는 문제점이 있게 된다. 
     이에 따라서 본 발명의 목적은 상기와 같은 종래의 버스 아비트래이션 방법에 따르는 문제점을 해결하기 위하여, 버스를 사용한 장치는 버스사용을 요구한 다른 모든 장치가 버스를 사용하고 난 뒤에야 버스 사용권이 할당되도록 하여 모든 장치에 대하여 공평한 버스 사용분배가 이루어지게 하는 버스 사용 장치를 제공하는데 있다.
Patent KR-100358682-B1 (KR)
Title: 증기발생기의이차회로내에서이동하는물체를포획하는장치
IPC: G21D1/00
Filed: 1992-12-01
Granted: 2003-01-24
Abstract: 포획장치는 핵 설비의 증기 발생기내 또는 이차회로 내의 이동하는 물체를 포획하는 것을 가능하게 한다. 
     이것은 증기 발생기의 튜브다발 싸개 상부부품(10)과 압력싸개(7)사이에 위치한 격자(6)에 의해 필수적으로 구성된다. 상기 격자의 메쉬의 크기는 일차회로의 튜브다발의 튜브사이를 막히도록 하는 물체가 통과하지 못하도록 조정한다. 
     본 발명은 가압된 핵 반응기의 증기 발생기에 적용된다.
Patent KR-960012993-B1 (KR)
Inventor: INOUE SATOSHI
IPC: G06F13/38
Filed: 1992-12-24
Granted: 1996-09-25
Abstract: 내용없음
Patent KR-960015285-B1 (KR)
Title: System for evacuating air from moulds for vulcanizing tyres
Inventor: FACCENDA MICHEL
IPC: B29C33/10
Filed: 1991-03-06
Granted: 1996-11-07
Abstract: In a system for evacuating air from moulds for vulcanizing tyres, the air and vulcanization gases trapped in the various interstices of the mould (1) are evacuated to the outside of the moulding part through a part which serves as a vent (3) and which contains one or more direct passage chambers (4) of constant width on the so-called bottleneck part which are dimensioned so as to prevent the passage of the rubber.
Patent KR-950006815-B1 (KR)
Title: Diggers for tractor
Inventor: YUN CHANG-SHIN
IPC: A01D13/00
Filed: 1993-02-25
Granted: 1995-06-23
Abstract: A potato harvesting unit drawn by a tractor comprises a couple of frames (1) equipped with left and right support panels (4, 5), each panel comprising an inner plate (2) and an outer plate (3), a connection member (7) with three connection points which is movably mounted on the frame, a long plowshare (55) located in front of the unit to excavate tubers up with soil, a sieve roller (22) located next to the plowshare, an endless sieve chain (34) for separating and transferring the harvested tubers, and a couple of guide plates (52) gathering harvested tubers into the central portion, which are hinged to both inner plates(2). A pneumatic cylinder (14) is mounted on the connection member to move it left and right. The sieve roller and sieve chain are rotated and run along the opposite direction to the movement of the tractor by a roller driving chain (24) and a V-belt connected with the power transmission shaft.
Patent KR-100248616-B1 (KR)
Inventor: MAKIYA SHITO
IPC: H04N5/335
Filed: 1993-03-18
Granted: 2000-03-15
Abstract: 본 발명은 수직방향으로 배열된 복수의 센서열의 수직으로 대응된 화소를 대략 동시에 샘플링하는 리니어센서를 제공한다. 복수의 수평전송레지스터와 복수의 시프트게이트가 복수의 센서열에 대응하여 배설된다. 복수의 수평전송레지스터의 일단에는 수직전송레지스터가 배설된다. 수직전송레지스터에 있어서, 복수의 수평전송레지스터에 의해 전송된 신호전하가 수직방향으로 순차 전송된다. 수직전송레지스터의 출력측에는 전하/전압변환부가 배설된다. 수직으로 대응된 화소에 축적된 신호전하는 전하/전압변환부에 순차 반복하여 전송된다.
Patent KR-960008574-B1 (KR)
Title: Manufacture method of stack capacitor
Inventor: PARK CHOL-SOO
IPC: H01L27/108
Filed: 1993-03-24
Granted: 1996-06-28
Abstract: forming a first conducting layer (10) for a storage electrode which is to be contacted to the silicon substrate after forming a MOSFET, a BPSG layer and a TEOS layer (9); forming a pattern of a mask insulating layer (13) after stacking a buffer oxide (11), a second conducting layer (12) for the storage electrode and the mask insulating layer (13); etching the part of a second conducting layer (12) and the revealed buffer oxide (11); forming a third conducting layer (16) for the storage electrode; forming the pattern of the storage electrode (50) by etching the third and the second conducting layer (16,12), the revealed buffer oxide (11) and the first conducting layer (10); forming a tunnel storage electrode by removing the mask insulating layer (13) and the buffer oxide (11) inside and on top of the storage electrode (50) and the TEOS layer (9) on the bottom of the storage electrode (50); forming a capacitor dielectric film (17) and a conducting layer (18) for a plate electrode.
Patent KR-950012624-B1 (KR)
Title: Nutritious composition containing raw soybean milk an raw cow's milk
Inventor: CHONG CHAE-WON
IPC: A23L33/00
Filed: 1993-05-08
Granted: 1995-10-19
Abstract: The nutritional food formulation (I) is prepared with milk and soymilk at 2:1 ratio. (I) has protein 3.8-4.3%, fat 2.3-2.5%, carbohydrate 3.7-4.0%, water 89.0-90.0%, and Ca 45-50 mg%, Na 200-250 mg%, K 150-200 mg%, Fe 0.01-0.02 mg%, P 50-60 mg%, vitamin C 0.1-0.15 mg%, methionine 150-200 mg%, tryptophane 100-140 mg%, lysine 175-225 mg%. The ratio is determined using Wistar rat males 5 and females 5 from 40 g to 350 g weight for growth of 10 weeks, in the tests of running distance in the frame of a sieve, intelligence in Tread-mill, swimming, breed time and the blood tests of hematocrit and concentration of cholesterol and Ca ion.
Patent KR-970006923-B1 (KR)
Inventor: SANTOS BENJAMIN S
IPC: C10C3/00
Filed: 1993-05-07
Granted: 1997-04-30
Abstract: 내용없음
Patent KR-100192915-B1 (KR)
Inventor: LEE BYEONG-HEN
IPC: F16H59/02
Filed: 1993-09-01
Granted: 1999-06-15
Abstract: 본 발명은 단순화 되면서 제조가 수월할 뿐만 아니라 변속시 변속조작이 원활하게 이루어지는 차량용 수동변속기의 변속조작기구로서, 베이스판(2)을 소형화시키고 후진게이트레버(5)와 복귀스프링(6)이 고정 및 지지역할을 수행하는 체인지레버핀(3)에 스톱퍼핀(7)을 일체화 장착시키며, 후진 시프트레버(8)를 작동시키는 압입핀(9)을 5단 및 후진 시프트앤드(10)에 구형상으로 일체화시킨 구조로 되어 있다.
Patent KR-100304548-B1 (KR)
Title: Super lattice type led device
Inventor: PARK BYEONG U
IPC: H01L33/00
Filed: 1993-10-30
Granted: 2001-11-22
Abstract: PURPOSE: A super lattice type LED device is provided to improve a characteristic of low brightness by using a-SiC or a-C:H to form a light emitting layer between dielectric layers. CONSTITUTION: A transparent electrode(2) is formed on an upper portion of a substrate(1). The first dielectric layer(3) is formed on an upper portion of the transparent electrode(2). A light emitting portion(10) is formed on an upper portion of the dielectric layer(3). The second dielectric layer(4) is formed on an upper portion of the light emitting portion(10). An upper electrode(5) is formed on an upper portion of the second dielectric layer(4). The light emitting portion(10) is formed by laminating a multitude of light emitting layers(11) and a multitude of dielectric layers(12), alternately. The first and the second dielectric layers(3,4) and the dielectric layers(12) are formed by a-SiNx. The light emitting layers(11) are formed by a-C:H or a-SiC.
Patent KR-960013276-B1 (KR)
Title: Full electronic exchanger
Inventor: KIM WOOK
IPC: H04M3/36
Filed: 1993-12-09
Granted: 1996-10-02
Abstract: The method is for measuring the nearest traffic intensity as the actual value and the gnerates the performance of packet exchange in the PBX. The method comprises the steps of: making the software exchanging the packet to accumulate and count a number of transmitting and receiving packets in the buffer by driving the timer for the measuring period of time and then initializing related variables; claiming the S/W to accumulate a number of transmitting and receiving packets processed by the S/W; and calculating the packet traffic intensity upon a request of measuring result.
Patent KR-970010663-B1 (KR)
Title: Silicon acceleration sensor and its fabrication
Inventor: LEE JONG-HYUN
IPC: H01L29/84
Filed: 1993-12-24
Granted: 1997-06-30
Abstract: A bridge type silicon sensor having eight beam which can sense an acceleration and a vibration is disclosed. The method of manufacturing the bridge type silicon sensor includes the steps of: forming an epitaxial layer 5 on a silicon substrate 1; forming a resistor by thin oxide 2' and impurities diffusion processes; etching the thin oxide 2' and the epitaxial layer 5; forming PSL(7; Porous Silicon Layer); and forming a mass 8 by using a mass loading or electro-planting technic; etching the PSL 7 to form an gap 9.
Patent KR-960013585-B1 (KR)
Title: Method for dyeing of polyamide and polyester cloth
Inventor: NAM BOK-KYU
IPC: D06P5/00
Filed: 1993-12-31
Granted: 1996-10-09
Abstract: The polyamide and polyester fabric are dyed by the steps of: treating with a solution containing thickening agent, dyeing accelerator(I), crosslinking agent(II) and isopropyl alcohol before dyeing, and then heat-treating at a temperature of 150-180 deg.C for 30-90 sec. During the dyeing processes, the solution containing an amine compound is treated by spraying or roller printing, followed by dyeing the bridged fabric with the amine compound for a heat-treatment to reveal a special patterns.
Patent RO-121864-B1 (RO)
Title: Hydraulic device for suspending-operating concentric double string of productionpipes
Inventor: URSU COSTEL
IPC: E21B21/00
Filed: 2003-05-14
Abstract: The invention relates to a hydraulic device for suspending-operating the concentric double string of production pipes, used for controlled advance and/or upwards or downwards simultaneous operation of two concentric strings of production pipes upon the well exploitation. According to the invention, the hydraulic device for suspending-operating the concentric double string of production pipes, provides the supporting and the upward or downward operation of two concentric strings of production pipes, concomitently with a simultaneous fluid circulation from the surface into the well and from inside the well up to the surface, by that, its cylindrical body (1) has a threaded portion inside for supporting a metallic piece (4) wherein there is suspended a string of pipes (5) of small diameter, through a connection piece (6). Above the connection piece (6) there is screwed a part (9) provided with a bend (10), for discharging the circulation fluid. At the lower side, the cylindrical body (1) is integral with a piece (9), which has the role of supporting the weight of the string of production pipes (12) of large diameter through another connection part (13) sliding vertically, the sealing between the circulation directions of the circulation fluid which penetrates into the device through a tap (2) located towards the upper side of the cylindrical body (1), on the generatrix thereof, there being made with a ring (14) a rubber gasket (15) and a sealing ring (16). In the situation of being used as pumping head, at the lower part of the cylindrical body (1), the hydraulic device for suspending-operating a double concentric string of production pipes has a piece (17) which has a connecting flange (18) at the landing head and a connection flange (19) at the mixing line.
Patent RO-122542-B1 (RO)
Title: Bola-amphiphilic material with ester structure and process for obtaining the same
Inventor: SIMION DEMETRA
IPC: C07C67/08
Filed: 2006-05-30
Abstract: The invention relates to a bola-amphiphilic material with ester structure, with possible applications in the processes for separation through membrane, and to a process for obtaining the same. According to the invention, the material is self-assembled in vesicular aggregates with a dimension of 200...300 nm, wherein there may be incorporated organic substances. According to theinvention, the process consists in the estherification of 1,10-decandiole with maleic anhydride, in benzene, there being obtained a diacid diester to which, thereafter there is added, in alkaline medium, sodium thio-acetate, there being formed 1,10-decandiyl ester derivative of the formula I, as crystals which are to be dissolved into an aqueous solution, with pH=8.
Patent RO-123573-B1 (RO)
Title: 6-o-substituted macrolide derivatives, process for preparing the same, pharmaceutical composition and use thereof
Inventor: OR YAT SUN
IPC: A61P31/04
Filed: 1997-09-02
Abstract: The invention relates to 6-O-substituted macrolide derivatives or a pharmaceutically acceptable salt thereof, to a pharmaceutical composition comprising the said derivatives and to a process for preparing the same. According to the invention, the 6-O-substituted macrolide derivative is represented by the formula (IV) whose substituents are those presented in the description of the invention and it can be employed in the preparation of a medicament for the control of the bacterial infection in a mammal. The claimed pharmaceutical composition comprises a therapeutically-effective amount of the said derivative in combination with a pharmaceutically acceptable carrier. The process, as claimed by the invention, consists in treating a compound of the formula (II), whose substituents are those presented in the description, with methane-sulphonic anhydride in pyridine, after which the methane-sulphonyl derivative is treated with an amine and the resulting compound with an alkaline metal hydride and carbonyl-diimidazole, the product obtained thereby being then treated with a diamine, after which the so obtained product is subjected to cyclization with a diluted mineral or organic acid, while optionally deprotecting and isolating the desired product.