baber/WOPTO huggingface dataset:
Patent DE-69812983-T2 (DE)
Inventor: AMEDIO C
IPC: C07F9/09
Filed: 1998-01-27
Granted: 2004-01-08
Abstract: A process for preparing a phosphodiester of the formula: is described that involves (1) reaction of a first alcohol with phosphorous trichloride to form a phosphorodichlorodite, (2) reaction of the phosphorodichlorodite with an amine to form a phosphorodiamidite, (3) reaction with a second alcohol (which may be the same as the first alcohol) to form a phosphoramidite diester, and finally, (4) hydrolysis and oxidation of the phosphoramidite to form the phosphodiester. R and R1 may represent aliphatic, aromatic, heterocyclic, peptidic, peptoid, deoxyribo- or ribonucleotidic or nucleosidic, or organic chelating moieties.
Patent DE-69814871-T2 (DE)
Inventor: ZAHEDI MIR SAEED
IPC: A61F2/64
Filed: 1998-08-13
Granted: 2004-02-19
Abstract: A lower limb prosthesis for an above-knee amputee has an adaptive control system which includes a knee flexion control device arranged to resist flexion at the knee joint both hydraulically and pneumatically by means of a dual piston and cylinder assembly. Sensors arranged to sense knee bending moments and knee flexion angle provide electrical signals which are fed to a processing circuit for automatically adjusting the hydraulic and pneumatic resistance to flexion according to the activity mode of the amputee and, when walking, according to the speed of the cylinder containing hydraulic fluid. The hydraulic resistance to flexion predominates during the stance phase and pneumatic resistance predominates during the swing phase. Provision is made for programmable resistance during level walking, walking on an incline, descending stairs and during a stumble.
Patent DE-69818043-T2 (DE)
Inventor: KLOPOTEK PETER J
IPC: A61F9/013
Filed: 1998-06-01
Granted: 2004-06-17
Abstract: Methods and apparatus are disclosed for removal of biological tissue slices or layers, preferably in the form of lamellar sections of predetermined shape and thickness employing a reference member that engages a target tissue site and cooperates with a cutter in order to remove the tissue segment or lamella. The cutter can include a flexible cutting element such as a wire or band element that is brought into physical contact with a guiding edge integrated with, or otherwise coupled to, the reference member. Alternatively, the cutter can include a stiff rigid blade element that is maintained in contact with the guiding edge. The cutter is drawn along a path defined by the guide edge through the tissue to sever, at least partially, a tissue section. In one particularly useful aspect of the invention, devices for keratectomy are disclosed employing an ocular reference member that engages the upper central region of the cornea and cooperates with a cutter to remove a lamellar segment from the cornea. Such lamellar resections are useful in preparing the cornea for further surgery (by mechanical or laser surgical techniques), or in performing refractive keratectomy directly upon the eye, or in treating (e.g., smoothing) the corneal surface to correct abnormalities, (e.g., to remove ulcerated tissue or otherwise improve the optical properties of the cornea).
Patent DE-69826279-T2 (DE)
Inventor: DRUMGOOLE J
IPC: F42D5/045
Filed: 1998-05-15
Granted: 2005-11-17
Abstract: A portable apparatus for mitigating the effects of chemical, biological and/or radiological agent containing explosive devices within a defined area is disclosed. The apparatus is an inflatable, easily portable containment device and includes: explosive blast containment means for substantially containing explosive blast over-pressure and blast fragmentation particles caused by an explosive blast to a substantially defined area; chemical, biological and/or radiological agent mitigation means for substantially mitigating the effects of an explosively deployable chemical, biological and/or radiological agent within the substantially defined area; and an inflatable air-beam suspension support structure having a substantially open base portion, a plurality of lateral support members and a capping structure which, when inflated, establishes the substantially defined area and supports the blast containment and agent mitigation means.
Patent DE-69826531-T2 (DE)
Inventor: SHANBROM EDWARD
IPC: C12N9/64
Filed: 1998-06-23
Granted: 2005-09-22
Abstract: Enhanced production of cryoprecipitate is produced by dehydrating an individual unit of plasma prior to a low temperature step used to produce cryoprecipitate. This dehydration is accomplished either by placing a water absorbing material within a blood bag so that plasma occupying the bag will become dehydrated or by placing the water absorbing material within a cartridge so that plasma becomes dehydrated upon flowing through the cartridge. The preferred water-absorbing material is a cross-linked chromatographic gel having pores too small to admit clotting proteins, but large enough to admit water molecules. Suitable gels are made from carbohydrates or polyacrylamide. Carbohydrate gels such as Sephadex3, produced by Pharmacia-Upjohn, are particularly preferred in the present invention. An alternative embodiment of the invention replaces the simple water-absorbing gel with one that also has ion exchange capabilities, such as DEAE (diethy-aminoethyl) Sephadex3 which has a special affinity for a number of blood clotting factors collectively known as the prothrombin complex. Following the dehydration step the DEAE Sephadex3 is eluted to produce prothrombin complex.
Patent DE-69828826-T2 (DE)
Inventor: MANI KRISHNAMURITY N
IPC: C13B20/18
Filed: 1998-11-11
Granted: 2005-07-14
Abstract: The invention is a process for desalting aqueous solutions, which are initially acidified to a pH of about 3 or less. Then, the acidified solution is fed into a desalting compartment of an electrodeionization cell which contains a suitable ion exchange material and is isolated from an adjacent concentrating compartments by an anion and a cation exchange membrane. The concentrate compartment contains a netting or another suitable material that promotes turbulence in a flowing feed stream. Water is supplied to the concentrate compartment. A DC current passes through the electrodeionization cell to produce a substantial desalination of the feed solution. A less acidic desalted solution and a concentrate waste solution are withdrawn from the electrodeionization cell.
Patent DE-69837821-T2 (DE)
Inventor: JAUSSAN VERONIQUE
IPC: A23L29/231
Filed: 1998-03-31
Granted: 2008-01-31
Abstract: A nutritional composition for diabetics. The composition contains a protein source, a lipid source, and a carbohydrate source. The composition includes a fibre mixture containing a viscous soluble fibre and inulin, a hydrolysate of inulin, or both. The fibre mixture may also contain insoluble fibre. When in liquid form, the nutritional composition has a low viscosity and excellent tube flow rates.
Patent DE-69906818-T2 (DE)
Inventor: HIDAKA KATSUHIKO
IPC: G03F7/004
Filed: 1999-11-12
Granted: 2004-02-26
Abstract: A positive photosensitive printing plate is prepared wherein the photosensitivity is to near-infrared rays which do not induce a chemical change in a photosensitive component. The photosensitive material has an inclined structure from the viewpoint of dissolution of the irradiated portion in an alkali developer. The dissolution rate is such that it continuously increases from the upper, surface part of the photosensitive material to the lower part of the photosensitive material. This effect may be enhanced by diffusion of a material, preferably a polar compound, such as H2O, from the surface toward the inner lower part of the photosensitive material. Techniques for accomplishing the diffusion include contacting the surface of the photosensitive material with an atmosphere of high humidity or overlaying the photosensitive material with a layer of protective material (paper) containing moisture and heating the resultant composite. The photosensitive material may include a solubility suppressing agent such as a sulfonic acid ester or a compound having a triarylmethane skeleton.
Patent DE-69926852-T2 (DE)
Inventor: WILS RONALD PETER JOANNES
IPC: A61C8/00
Filed: 1999-10-27
Granted: 2006-06-29
Abstract: A series of dental implants is proposed, each of which is stepped, the drill diameter for the largest step section of the smaller implant corresponding to the drill diameter for the smaller stepped section of the subsequent larger implant. The invention also relates to a dental implant consisting of a stepped shaft section provided close to the superstructure end with an external engagement surface for fitting said superstructure thereover. A collar, joined to the shaft section, extends around said external engagement surface at some distance therefrom. The internal surface thereof is conically divergent with respect to the axis of the shaft section and part of the superstructure can be placed in a stable manner in the space delimited between the inner surface of the collar and the external engagement surface. <IMAGE>
Patent DE-69933588-T2 (DE)
Inventor: THOMAS NICHOLAS
IPC: C12M1/20
Filed: 1999-03-17
Granted: 2007-08-16
Abstract: Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel for supplying liquid sample thereto and an outlet channel for removal of liquid sample therefrom, a cover plate positioned over the base plate to define the chambers and connecting channels, the cover plate being supplied with holes to provide access to the channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of a variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells. <IMAGE>
Patent HU-E030700-T2 (HU)
Title: Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity
Inventor: ZEMBOWER DAVID E
IPC: C07D405/06
Filed: 2003-12-19
Abstract: The present invention provides compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2  and B are as described generally and n classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
Patent HU-E029231-T2 (HU)
Title: Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Inventor: TAO ZHI-FU
IPC: A01N43/42
Filed: 2011-05-25
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Patent HU-E032569-T2 (HU)
Title: Methods for identifying antibodies with reduced immunogenicity
Inventor: HARDING FIONA A
IPC: G01N33/68
Filed: 2013-09-18
Abstract: The disclosure describes methods of identifying a variant of a reference antibody with reduced immunogenicity as compared to the reference antibody. The disclosure further describes variants of a reference anti-TNF-α antibody having reduced immunogenicity as compared to the reference anti-TNF-α reference antibody.
Patent MD-3331900-T2 (MD)
Inventor: MAHR ANDREA
IPC: G01N33/574
Filed: 2016-08-05
Abstract: Prezenta invenţie se referă la peptide, proteine, acizi nucleici şi celule pentru utilizare în metode imunoterapeutice. În particular, prezenta invenţie se referă la imunoterapia cancerului. În plus, prezenta invenţie se referă la epitopii peptidici ai celulelor T citotoxice asociate tumorii, singuri sau asociaţi cu alte peptide asociate tumorii, care pot servi, de exemplu, drept componente farmaceutice active ale formulelor de vaccin care stimulează răspunsurile imunitare antitumorale sau pentru stimularea celulelor T ex vivo şi transferarea la pacienţi. Peptidele legate de molecule ale complexului major de histocompatibilitate (MHC), sau peptidele ca atare, pot fi, de asemenea, ţinte ale anticorpilor, ale receptorilor solubili ai celulelor T şi ale altor molecule de legare.
Patent MD-3347360-T2 (MD)
Inventor: MORPHY JOHN RICHARD
IPC: C07D495/20
Filed: 2016-09-06
Abstract: Prezenta invenţie furnizează noi inhibitori ai ROR gama-t şi compoziţiifarmaceutice cu aceştia.
Patent TR-200000589-T2 (TR)
Title: Tümöre karşı maddeler olarak 4-amino -2(5H)-furanonların ve 4-amino-2(5H)-tiyofenonların üreido ve tiyoüreido türevleri.
Inventor: MENTA ERNESTO
IPC: A61K31/4725
Filed: 1998-09-01
Abstract: Bu bulusun konusu, ilaçlar, özellikle tümöre karsi maddeler olarak kullanilmak üzere genel formül (I)'e sahip bilesikler, bunlarin saf stereoizomerleri veya karisimlari ve ayrica farmasötik olarak kabul edilebilir asitler veya bazlarla olusturuldugu tuzlardir; buradaki formülde, A, oksijen veya kükürttür; X, oksijen veya kükürttür; R1 ve R2, bagimsiz olarak hidrojen veya 1-6 karbon atomuna sahip bir alkil grubudur; R, alkil, sikloalkil, alkilsülfinil, alkilsülfonil, hidroksialkil, naftil, ikamesiz veya ikameli olabilen fenil grubundan seçilir; veya R, seçime bagli olarak benzo ile yogunlastirilan, oksijen, kükürt ve azottan seçilen 1-3 heteroatom içeren 5- veya 6-üyeli bir heterosikldir.
Patent TR-200001026-T2 (TR)
Title: Nötrofil elastaz inhibitörü olarak pirolopirolon türevleri.
Inventor: DOWLE MICHAEL DENNIS
IPC: A61P1/02
Filed: 1998-09-07
Abstract: Bu bulus (I) formüllü terkipler temin eder.(I) formüllü terkipler solunum bölgesinin enflamatuvarli hastaliklarinin tedavisinde kullanislidir.
Patent TR-200003244-T2 (TR)
Title: Yeni kullanım
Inventor: GURLEY DAVID
IPC: A61P25/28
Filed: 1999-04-28
Abstract: Bu bulus bir nikotinik reseptör agonistinin pozitif bir modülatörünü ihtiva eden farmasötik kompozisyonlar ile ilgili olup, sözü geçen pozitif modülatör sözü geçen nikotinik reseptör agonistinin etkinligini arttirma kabiliyetine sahiptir.
Patent TR-200003766-T2 (TR)
Title: Alkoksile edilmiş polialkilenimin dağıtıcıları içeren çamaşır yıkama bileşimleri.
Inventor: CLEARY JAMES ALBERT
IPC: C11D3/37
Filed: 1999-06-09
Abstract: (FORMÜL VAR) Formül I'e sahip alkoksile polialkilenimin leke dagiticilari içeren deterjan bilesimleri açiklanmaktadir, R, C2-C6 lineer alkilen, C3-C6 bölümlenmis alkilen ve bunlarin karisimlaridir; B bölümlemenin devamidir; E, -(R1O)m(R2O)n R3 formülüne sahip alkilenoksi birimidir, R1, 1, 2 propilen, 1, 2-bütilen, ve bunlarin karisimidir; R2 etilen; R3 hidrojen, C1-C4 alkil, ve bunlarin karisimidir; m yaklasik 1-10'dur; n yaklasik 10-40'tir; W,X,Y yaklasik 4-200'dür; -(R2O) biriminin ilistirilmesinden önce en az bir -(R1O) birim destege ilistirilmistir ve m+n en az 12'dir; bahsedilen dagiticilar beyazlatma ile uyumludur. Açiklanan alkoksile polialkileniminler beyazlatici içeren çamasir önceden suya bastiricilari ve beyazlatma maddeleri içinde leke dagiticilari olarak kullanima da uygundur.
Patent TR-200101644-T2 (TR)
Title: TNF-ALFA önleyicileri olarak siklik hidrazin türevleri.
Inventor: BROADHURST MICHAEL JOHN
IPC: C07D233/34
Filed: 1999-12-02
Abstract: Formül (I)'in hidrazin türevleri ve hücrelerden tümör nekroz faktörü alfanin (TNF-alfa) birakilmasini önleyen farmasötik olarak uygun olan tuzlari. Bunlar özellikle iltihaplanmali ve otoimmün hastaliklarin, osteoartrit'in, solunumla ilgili hastaliklarin, tümörlerin, kaseksi'nin, kalpdamar sistemi hastaliklarinin, yüksek atesin, kanamalarin ve septisemi'nin tedavisinde ilaç olarak kullanilabilmektedirler. (FORMÜL VAR)
Patent DE-602004007081-T2 (DE)
Inventor: NICETTO ROMEO
IPC: A47L21/02
Filed: 2004-09-06
Granted: 2008-02-21
Abstract: A machine (1) with vibrating tank for drying and polishing cutlery, comprising a support and containment structure (2) that supports elastically a treatment tank (4) that is designed to contain a drying and polishing material. The treatment tank (4) can be actuated with a vibrating motion and is connected to a port (8) for loading the cutlery to be dried and polished and to a port (9) for unloading the dried and polished cutlery. The treatment tank (4) has a circular plan shape and is provided internally with a rising channel that is arranged helically around the axis of the treatment tank from the bottom of the tank to the unloading port (9). The loading port (8) is spaced laterally from the axis of the treatment tank. <IMAGE>
Patent DE-602004009314-T2 (DE)
Inventor: HRECZUK-HIRST DALE H
IPC: C07K1/107
Filed: 2004-08-12
Granted: 2008-02-07
Abstract: A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
Patent DE-602004011683-T2 (DE)
Inventor: BROWN KATHERINE A
IPC: G08B13/24
Filed: 2004-11-03
Granted: 2009-01-29
Abstract: A durable radio frequency identification tag. A preferred embodiment of the invention provides a durable radio frequency identification tag comprising: a flexible substrate including a first major surface and a second major surface opposite the first major surface; a radio frequency identification antenna attached to the first major surface of the substrate; an integrated circuit attached to the antenna; and a thermoplastic guard attached to the flexible substrate adjacent the integrated circuit. The present invention also provides a method of manufacturing a durable radio frequency identification tag.
Patent DE-602005003071-T2 (DE)
Inventor: LOPEZ DA CRUZ NICOLAS
IPC: B60T13/14
Filed: 2005-07-14
Granted: 2008-08-21
Abstract: The sealing unit has a cap molded to a skirt (12) including a cavity (13). A sealing lip (19) is crushed between a lower side of the cap and an upper side (17) of the skirt. An electric circuit e.g. reed switch circuit, to detect level of liquid in a reservoir is placed in the cavity. The lip follows circumference of an orifice (18) situated on the upper side of the skirt. Independent claims are also included for the following: (A) a hydraulic reservoir for a motor vehicle (B) a method of assembling a sealing unit.
Patent DE-69002177-T3 (DE)
Inventor: BAKAL ABRAHAM I
IPC: A23L27/60
Filed: 1990-03-14
Granted: 2000-10-26
Abstract: This invention relates to foodstuffs containing maltitol. More particularly, this invention relates to improved fat-containing foodstuffs, wherein the improvement comprises the partial or total replacement of the fat by a taste effective amount of maltitol.
Patent DE-69100491-T3 (DE)
Inventor: SZAFRANSKI PIERRE
IPC: A63C5/12
Filed: 1991-02-02
Granted: 1999-06-24
Abstract: The present invention relates to a method of joining a support device and a ski, and a ski and a support device which are adapted for implementing this method. This method is characterised in that, at the location of each of the respective two joining surfaces, a layer of heat-meltable material (2a, 4a) is provided, heating-up of the two layers of heat-meltable material (2a, 4a) in contact with one another is caused so as to raise them to a temperature greater than the melting point of the heat-meltable material of each layer in contact, while applying the ski (1) and the support device (2) against one another under pressure, and the molten material is then allowed to cool. <IMAGE>
Patent DE-69309928-T3 (DE)
Inventor: BROD RAMAH JESSICA
IPC: C08L31/04
Filed: 1993-06-29
Granted: 2004-08-26
Abstract: Compositions comprising (a) an ethylene-mixed unsaturated ester copolymer or (b) two or more ethylene-unsaturated ester copolymers differing, for example, in their ester chains improve the low temperature properties of fuel oils.
Patent DE-69400455-T3 (DE)
Inventor: ABONDANCE ROGER
IPC: A63C5/12
Filed: 1994-04-13
Granted: 2003-08-07
Abstract: This ski includes longitudinal reinforcing elements (9) each bearing on an edge (8), and forming the side walls of the ski, which extend, at least in the case of one of them, over a part of the height of the latter, and a shell (10) forming the topsheet (upper face) and a part of at least one of the lateral walls of the ski, and the longitudinal sides (12) of which rest and are fastened on the topsheet of the side walls (9), the respective heights of a side wall and of the shell over at least one of the side faces of the ski varying in the same proportions over the length of the ski. <IMAGE>
Patent DE-69712678-T3 (DE)
Inventor: CHEN TY-FOUNE
IPC: G06F11/32
Filed: 1997-07-15
Granted: 2010-01-14
Abstract: The monitoring system uses intelligent agents which are installed on each server. These agents execute, after formulation of client requests, a control state for each server by measuring and storing the parameters indicating the state and the condition of the server at a given instant. The data is collected automatically as a function of the domains examined and processed by the server in a systematic manner. The data is presented in the form of presentation reports contained in constructed pages evolving in a dynamic manner. The clients navigator (search engine) accesses these dynamic pages presenting the collected and processed pages responding to the request. The method use the following modules: - a page constructor module; - a semantic knowledge module; - a system data construction module; - a generic tool module which helps in construction of high level hyper-text language pages.
Patent DE-69809362-T3 (DE)
Inventor: LELEU JEAN BERNARD
IPC: A23L27/30
Filed: 1998-09-23
Granted: 2009-04-16
Abstract: New crystalline maltitol forms containing: (a) bipyramidal; (b )prismatic; or (c) a mixture of bipyramidal and prismatic crystals. The bipyramidal-form crystals comprise regular octahedra of square base 50-500 mu m and the prismatic form, of length greater than width (l = 100 - 400 mu m and w = 20 - 100 mu m), comprising tetrahedra. Independent claims are also included for the preparation of: a) compositions containing bipyramidal crystals by the crystallisation of a maltitol syrup with a maltitol content greater than 87 (preferably greater than 96) %, and a maltotriitol content less than 1%; b) compositions containing prismatic crystals by crystallisation of a maltitol syrup with a maltitol content greater than 87 (preferably greater than 96)%, and a maltotriitol content greater or equal to 4%; c) compositions containing bipyramidal and prismatic crystals by crystallisation of a maltitol syrup with a maltitol content greater than 87 (preferably greater than 96)% and a maltotriitol content between 1 - 4%.
Patent DE-69915974-T3 (DE)
Inventor: MONZIO COMPAGNONI BRUNO
IPC: B21B31/10
Filed: 1999-10-18
Granted: 2009-07-09
Abstract: A rolling-mill stand comprises, in combination: at least two rolls (15) supported by respective mounts (16, 17) with adjustment and blocking tie rods (18, 19), supporting feet (20), and supports (20a). According to the invention, the said rolls (15) are mounted on a central module (11), whilst the corresponding mounts (16, 17), tie rods (18, 19), feet (20), and supports (20a) are mounted together in the form of two side modules (12, 13). A fast-clamping and fast-release system (21) is moreover provided for the stable but releasable connection between the said central module (11) and the said two side modules (12, 13). <IMAGE>
Patent DK-1202152-T3 (DK)
Inventor: WELLHOEFER STEFAN
IPC: H05K7/20
Filed: 2000-10-18
Granted: 2002-11-25
Abstract: The system has a housing with at least one, preferably two closed vertical or inclined sections (3,4) of at least mainly thermally conducting material suitable for accommodating heat generating electrical and/or electronic equipment such as computers or printers, with heat bridges for conducting equipment heat to at least one housing wall surface. A flue chamber has a lower cool air inlet and at least one upper outlet opening for heated air.