baber/WOPTO huggingface dataset:
Patent CA-2891047-A1 (CA)
Title: Tumor tissue based biomarkers for bevacizumab combination therapies
Inventor: DELMAR PAUL
IPC: A61K39/395
Filed: 2011-01-18
Abstract: The present invention provides methods for improving the progression- free survival of a patient suffering from gastrointestinal cancer, in particular, metastatic colorectal cancer (mCRC), by treatment with bevacizumab (Avastin®) in combination with a chemotherapy regimen by determining the expression level of one or more of VEGFA, HER2 and neuropilin relative to control levels in patients diagnosed with gastrointestinal cancer, in particular, metastatic colorectal cancer (mCRC). The present invention further provides for methods for assessing the sensitivity or responsiveness of a patient to bevacizumab (Avastin®) in combination with a chemotherapy regimen, by determining the expression level of one or more of VEGFA, HER2 and neuropilin relative to control levels in patients diagnosed with gastrointestinal cancer, in particular, metastatic colorectal cancer (mCRC).
Patent CA-2892231-A1 (CA)
Inventor: KARKOW DOUGLAS W
IPC: F23D14/80
Filed: 2014-02-14
Abstract: A burner supporting primary and secondary combustion reactions may include a primary combustion reaction actuator configured to select a location of the secondary combustion reaction. A burner may include a lifted flame holder structure configured to support a secondary combustion reaction above a partial premixing region. The secondary flame support location may be selected as a function of a turndown parameter. Selection logic may be of arbitrary complexity.
Patent CA-2892801-A1 (CA)
Title: Composition de cimentation comprenant des ethers de cellulose non anionique modifies hydrophobiquement et son utilisation
Inventor: KUHLMAN ROGER L
IPC: C09K8/487
Filed: 2013-12-06
Abstract: L'invention concerne une composition et un procédé pour cimenter un cuvelage dans un trou de forage d'un puits à l'aide d'une composition de cimentation aqueuse comprenant (a) de l'eau, (b) une composition de cimentation comprenant (i) un ciment hydraulique, (ii) un polymère modifié hydrophobiquement, (iii) un dispersant et, éventuellement, (iv) un ou plusieurs autres additifs généralement ajoutés aux compositions de cimentation aqueuses utilisées pour la cimentation des cuvelages dans les puits de forage de puits. De préférence, l'hydroxyéthylcellulose modifiée hydrophobiquement présente une substitution molaire d'oxyde d'éthylène de 0,5 à 3,5, un degré de substitution hydrophobe de 0,001 à 0,025, une masse moléculaire moyenne en poids de 500 000 à 4 000 000 de Daltons, et le dispersant est un polymère sulfoné, un condensat de mélamine formaldéhyde, un condensat de naphtalène formaldéhyde, un polymère de polycarboxylate ramifié ou non ramifié. De préférence, la composition de cimentation aqueuse est pompée vers le bas dans le cuvelage, il est pompé vers le haut dans l'espace annulaire entourant le cuvelage jusqu'à ce que la composition aqueuse remplisse la partie de l'espace annulaire que l'on souhaite sceller, puis la composition de cimentation aqueuse est maintenue en place jusqu'à la prise du ciment.
Patent CA-2893110-A1 (CA)
Inventor: DIETZ TIMOTHY G
IPC: A61B17/32
Filed: 2013-11-27
Abstract: An ultrasonic instrument comprises an ultrasonic transducer, an acoustic waveguide, and an ultrasonic blade. The blade includes a pair of obliquely extending edges. The obliquely extending edges diverge away from the longitudinal axis of the waveguide and away from each other along respective paths extending distally in relation to the waveguide. A distal portion of the blade is wider than a proximal portion of the blade along a plane. The blade further includes a curved distal edge and several laterally presented surfaces. The laterally presented surfaces may provide combinations of concave and convex curvatures. The laterally presented surfaces may be angled and/or curved along one or more orthogonal planes associated with the longitudinal axis of the waveguide.
Patent CA-2893768-A1 (CA)
Inventor: GREENSPAN MICHAEL HARVEY
IPC: A61K31/74
Filed: 2013-12-06
Abstract: A composition for pain relief including synergistically effective amounts of an amino benzoate local anesthetic, methylsulfonylmethane (MSM), and ethoxydiglycol. A method of treating pain, by applying the composition to skin in an area of pain, and blocking nerve signals. A method of improving range of motion in an individual, by applying the composition to skin, relieving pain, and allowing the individual to have an improved range of motion at an area of pain.
Patent CA-2893972-A1 (CA)
Title: Particules de poudre-a-liquide anhydres
Inventor: FASSIH ALI
IPC: B01J13/02
Filed: 2013-12-17
Abstract: L'invention concerne une poudre comprenant des particules cur/enveloppe ayant une taille moyenne de particule inférieure à 1000 microns, chaque particule comprenant : 1) un cur liquide qui est sensiblement exempt d'eau et comprend un liquide polaire ayant une polarité de surface d'au moins 24 %, et 2) une enveloppe comprenant des particules hydrophobes.
Patent CA-2894100-A1 (CA)
Inventor: DIETRICH DAVE
IPC: A01D75/18
Filed: 2015-06-11
Abstract: This disclosure relates to the field of agricultural implements and in particular a harvest header for a combine.
Patent CA-2894210-A1 (CA)
Inventor: CHANTELOUP DENIS LUC ALAIN
IPC: B23K26/14
Filed: 2013-12-16
Abstract: L'invention concerne le domaine du soudage laser, et en particulier à une tête de soudage laser (1) destinée à être fixée sous une lentille de focalisation du laser et comprenant au moins une buse annulaire (5) pour l'injection d'un gaz protectif, et une chambre (3) de protection de la lentille de focalisation par un courant transversal d'air. La buse annulaire (5) est arrangée autour d'un axe optique (0) dégagé traversant la tête de soudage laser (1). La chambre (3) de protection de la lentille de focalisation par un courant transversal d'air comporte une admission d'air (9) et un échappement d'air (10) au droit de l'admission d'air (9) dans un plan sensiblement perpendiculaire audit axe optique (0). Cette tête de soudage laser (1) est configurée pour être fixée contre ladite lentille de focalisation sans aucune ouverture latérale entre la lentille de focalisation et ladite chambre de protection (3). Elle présente une distance (d) d'au moins 100 mm entre une sortie (18) de la buse annulaire (5) et ladite chambre de protection (3).
Patent CA-2896677-A1 (CA)
Inventor: WEISS THOMAS JEFFREY
IPC: G06Q40/04
Filed: 2013-04-08
Abstract: Methods and systems to prevent adverse exchange limit effects are disclosed. A method of message management includes tracking, at a gateway, a transaction count of trade messages communicated to an exchange via an exchange link. The method includes defining a first transaction limit based on the transaction count, and calculating a second transaction limit as a function of the first transaction limit, wherein the second transaction limit is to correspond to a reserve capacity associated with the exchange link. The method includes assigning a message priority to each of a plurality of trade messages to communicate to the exchange. The method includes communicating trade messages of the plurality of trade messages having a first message priority to the exchange when the transaction count is greater than the second transaction limit, and delaying or rejecting trade messages of the plurality of trade messages having a second message priority.
Patent CA-2896774-A1 (CA)
Title: A method of manufacturing a tubular medical implant
Inventor: KNAPP TROY D
IPC: A61F2/04
Filed: 2014-03-12
Abstract: A method of manufacturing a tubular medical implant is provided. The method includes forming a hollow first tube with a first diameter and a first plurality of pores formed thereon and a hollow second tube with a second unstretched diameter and a second plurality of pores formed thereon. The second unstretched diameter is greater than the first diameter. At least a portion of the first tube slides within the second tube to create an overlapped area of the first tube and the second tube. The first tube and second tube are then bonded together in the overlapped area.
Patent CA-2897768-A1 (CA)
Inventor: SLILATY STEVE N
IPC: C07D493/04
Filed: 2014-01-13
Abstract: The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.
Patent CA-2903612-A1 (CA)
Inventor: BRANCH DONALD R
IPC: C07D231/12
Filed: 2014-03-12
Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
Patent CA-2908508-A1 (CA)
Title: C. novyi for the treatment of solid tumors in humans
Inventor: SAHA SAURABH
IPC: A61K35/66
Filed: 2014-03-28
Abstract: The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1 x 103-1 x 107 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided.
Patent CA-2910977-A1 (CA)
Title: Program testing service
Inventor: SINGH LOKENDRA
IPC: G06F11/36
Filed: 2014-05-02
Abstract: A service provider network includes host computers that have various computing devices connected thereto. In order to test the operation of a program, a developer creates a program and one or more test cases for use in testing the program. The developer also identifies devices in the service provider network for use in testing the program. Once this selection has been made, a test request is submitted to the service provider network. When the service provider network receives the test request, the program is installed on the devices upon which testing is to be performed. The supplied test case is then utilized to test various aspects of the operation of the program on the devices. Once the testing of the program has completed, the results of the testing may be transmitted to the developer. A similar process might be utilized to test a program on a variety of device emulators.
Patent CA-2913004-A1 (CA)
Inventor: GASULL MORALES ALBERT
IPC: C11D3/37
Filed: 2014-05-20
Abstract: The present application relates processes that can be used to produce encapsulated benefit agents comprising a core and a shell that encapsulates said core, encapsulated benefit agents produced by such process and products comprising such encapsulated benefit agents as well as methods of making and using such products. Such process can be used to produce particles that offer the desired protection and release benefits when used in a varity of products.
Patent CA-2913101-A1 (CA)
Title: Rotor blade of a wind turbine and wind turbine
Inventor: ALTMIKUS ANDREE
IPC: F03D1/06
Filed: 2014-06-11
Abstract: The invention relates to a rotor blade of an aerodynamic rotor of a wind turbine, comprising:  at least a first and a second wing fence (810, 820), with the first wing fence (810) being arranged at the rotor blade in radial direction, in relation to an axis of rotation of the rotor, in a range between 25% and 40%, and the second wing fence (820) being arranged at the rotor blade in radial direction, in relation to an axis of rotation of the rotor, in a range between 45% and 60%.
Patent CA-2913973-A1 (CA)
Inventor: KOBEL PETER
IPC: B29C45/64
Filed: 2015-12-03
Abstract: An injection moulding machine comprises -    a movable moulding platen, -    a fixed moulding platen, -     a fixed support plate, and -    a clamping unit having =        a drive element which is preferably driven parallel with the infeed direction of the movable platen in order to introduce an actuating force into the clamping unit, and =        a linkage assembly between the support plate and the movable platen, which, for transmitting the movement of the drive element to the movable platen in the context of an infeed movement of the movable platen relative to the fixed platen, is connected in an articulated manner to the drive element, -    a configuration of the linkage assembly having three control arms, comprising =        an auxiliary control arm which is articulated on the support plate, = a central control arm which is articulated on said auxiliary control arm and is directly coupled to the drive element, and =        an output control arm interdisposed between the central control arm and the movable platen, and being coupled in an articulated manner such -     that the articulation axis between the central control arm and the output control aim runs on a non-circular motion path which has a reversal point, and -    that in a closing position of the movable platen the four articulation axes of the linkage assembly which are in each case formed between the support plate, the control arms, and the movable platen lie on a straight line which is perpendicular on a tangent on the motion path of the articulation axis between the central control aim and the output control arm, wherein the articulation axis in the closing position is located outside the reversal point of the motion path (B).
Patent CA-2914732-A1 (CA)
Title: Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups
Inventor: HAI TON THAT
IPC: G01N33/551
Filed: 2014-06-06
Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
Patent CA-2916271-A1 (CA)
Inventor: HEBBORN KEVIN A
IPC: H05B37/03
Filed: 2014-06-17
Abstract: The present disclosure is directed to a method for detecting a failure in a signal light. In one embodiment, the method includes monitoring operation of one or more light emitting diodes (LEDs) of the signal light coupled to a constant current driver, detecting a short circuit in at least one of the one or more LEDs and signaling a failure in the signal light when the short circuit is detected.
Patent CA-2916422-A1 (CA)
Inventor: JOHNSON TIM
IPC: E21B34/14
Filed: 2015-12-29
Abstract: Un assemblage de fond de trou est décrit. Lassemblage comprend un premier mandrin, un deuxième mandrin comprenant un localisateur, un outil de fond de trou comprenant une première et une deuxième surface de préhension, et un premier et un deuxième actionneur doutil de fond de trou. Loutil de fond de trou est placé coopérativement par rapport au deuxième mandrin, de sorte que lorsque le localisateur est placé dans un profil de localisation, le déplacement de loutil de fond de trou, en réponse à la sollicitation par le premier actionneur de loutil, a pour effet que la première surface de préhension est déplacée vers lextérieur pour établir un raccord de préhension avec lélément de contrôle de flux, et le déplacement de loutil, en réponse à la sollicitation par le deuxième actionneur de loutil, a pour effet que la deuxième surface de préhension est déplacée vers lextérieur pour se placer en raccord de préhension avec lélément de contrôle de flux.
Patent CA-2919094-A1 (CA)
Title: Traitement interferometrique au laser
Inventor: KUMAR KITTY
IPC: B23K26/354
Filed: 2014-07-22
Abstract: La présente invention se rapporte à un nouveau procédé de traitement axial à haute résolution à l'intérieur d'un film transparent mince sur un substrat à l'aide d'un laser femtoseconde. Ce confinement est prévu dans les films transparents en raison du motif d'interférence optique généré par le laser. Les interactions optiques non linéaires causées par le laser à durée ultracourte prédisent une forte ionisation avec un profil de densité électronique qui suit la forme du motif d'interférence optique. Au seuil d'exposition pour la structuration interne, la densité électronique atteint un seuil critique aux positions des maximales périphériques prédites afin de faciliter l'éjection quantifiée du film ou la formation de nano-vides minces à l'intérieur du film dans des plans de clivage au laser séparés périodiquement. Cette géométrie pour un clivage interne au laser n'a pas été mentionnée auparavant à l'intérieur d'un matériau transparent, et elle permet une maîtrise beaucoup plus grande de la modification au laser par rapport à une structuration du film sur l'ensemble du volume focal de laser ou à une structuration confinée à une interface film-substrat. La présente invention prévoit le confinement de cette structuration laser interne aux positions des maximales périphériques créées dans des motifs en trois dimensions maximum à l'intérieur de matériaux optiquement transparents qui ont des formes et des dimensions variables.
Patent CA-2921445-A1 (CA)
Inventor: POHLMAN JOE KIPTON
IPC: E04G27/00
Filed: 2013-02-08
Abstract: A portable, adjustable, and modular system for assembling ramps, wheelchair ramps, decks, patios, raised platforms decks, and other raised structures is described. The system is adjustable to accommodate at least one of variations in terrain and desired slope of the decking surface; avoids the use of bulky and performed ramp platforms; and is cost effective and simple to assemble. The system is made up of one or more adjustable structures comprising two H-frames secured by side rails. Each H-frame is made up of two upright leg components and a bar that spans between the leg components. Adjustable sleeves are used to vary the height of the H-frames. The side rails contain an internal ledge to receive dimensional lumber. The ramp may be sold in a kit with individual elements, but it is also designed to provide a frame substructure that can be used with conventional decking materials, railings, and handrails.
Patent CA-2922088-A1 (CA)
Title: Content receiving device, opening/closing mechanism, and container mechanism comprising the same
Inventor: PARK HYEON SOO
IPC: B65D83/04
Filed: 2014-08-25
Abstract: Disclosed is a content receiving device, an opening/closing mechanism, and a container mechanism comprising the same, the content receiving device comprising: a housing which opens to both sides applied to a container body; and an operating mechanism for controlling passage of content provided on the housing to move and guide contents, wherein the operating mechanism for controlling passage of content has an opening formed to communicate with a storage portion of the container body such that contents of the storage portion are moved. The present invention also adjusts the passage space and a receiving space, thereby limiting reception of contents more than the required amount; passage of the demand amount of contents is stably induced within a predetermined range; and contents are prevented from remaining more than is needed, together with interlocked limitation of the content receiving space, such that the amount of received contents is adjusted.
Patent CA-2924384-A1 (CA)
Title: Handle device
Inventor: CARLSSON FREDRIK
IPC: E05B47/06
Filed: 2014-10-06
Abstract: Handle device for operating doors, windows and the like, comprising a first element (3), which is rotatable about an axis of rotation, a second element (8, 108, 208, 308), and a coupling device which is designed to selectively allow and prevent relative rotation about the axis of rotation between the first and the second element. The coupling device comprises; a first coupling member (15, 115, 215, 315, 515, 615) being connected to the first element; a second coupling member (8, 150, 208, 350) being connected to constituting the second element and at least one engaging member (19, 119, 219, 319, 519) which is displaceable between an engagement position in which it simultaneously engages the first and the second coupling members to thereby prevent relative rotation between the first and second element and a release position in which it is disengaged from at least one of the first and second coupling members to thereby allow relative rotation between the first and second element. A drive member (21, 121, 221, 321, 421, 521, 621) is arranged axially displaceable, concentrically with said axis of rotation, by means of an electrical motor (6, 106, 206, 306, 406, 506) having a rotational output shaft (36, 136, 236, 336, 436, 536, 636). The engaging member and drive member comprise interacting contact surfaces arranged, during axial displacement of the drive member, to displace the engagement member from the release position to the engagement position. The drive member exhibits an interior recess (27, 127, 227, 327, 427, 527). A portion (36, 136, 236, 336, 436a, 536, 636) of the output shaft extends axially through the recess. A helical coil spring (38, 138, 238, 338, 538, 638) is arranged in the recess, concentrically about the output shaft, limitedly axially displaceable relative to the drive member and the output shaft and prevented from free rotation relative to the drive member or the output shaft. The output shaft or the drive member is provided with a radially extending spring engagement member (37, 137, 237, 337, 537, 637) which is arranged to engage the helical coil spring for axial displacement of the drive member relative to the output shaft upon rotation of the output shaft.
Patent CA-2924640-A1 (CA)
Inventor: YU WANGLIN
IPC: E21B37/06
Filed: 2014-09-23
Abstract: Cette invention concerne un additif anti-accrétion pour fluides de forage aqueux et ses procédés d'utilisation. L'additif anti-accrétion réduit l'adhérence des matériaux bitumineux et/ou à base de pétrole lourd aux surfaces métalliques telles que les surfaces de trépans, de trains de tiges, de tubage et autres. Plus spécifiquement, l'additif anti-accrétion comprend de 5 à 50 parties en poids d'un alcool propoxylé et de 95 à 50 parties en poids d'un alcool propoxylé et éthoxylé.