baber/WOPTO huggingface dataset:
Patent DK-2740794-T3 (DK)
Inventor: OKANO FUMIYOSHI
IPC: C12P21/08
Filed: 2012-08-03
Granted: 2018-06-14
Abstract: The purpose of the present invention is to produce an antibody having higher antitumor activity than conventional antibodies that target CAPRIN-1, which is specifically expressed on the surface of a cancer cell, and to provide the use of the antibody as an agent for the treatment and/or prophylaxis of cancer. The present invention provides the use, as an agent for the treatment and/or prophylaxis of cancer, of an antibody that identifies and targets a cancer antigen protein that is specifically expressed on the surface of a cancer cell. More specifically, the present invention provides a pharmaceutical composition for the treatment and/or prophylaxis of cancer, the pharmaceutical composition being characterized by containing, as an active ingredient: an antibody that has immunological reactivity with CAPRIN-1 protein and that comprises a heavy-chain variable region including amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light-chain variable region including amino acid sequences represented by SEQ ID NOs: 9, 10, and 11; or a fragment of said antibody.
Patent DK-2972528-T3 (DK)
Inventor: YE CHANGGENG
IPC: H01S3/30
Filed: 2014-03-17
Granted: 2018-03-05
Abstract: Optical fibers are provided for modal discrimination which include a central core and a cladding disposed about the central core. The central core has a non-circular and non- elliptical cross-section, and it is rotated about a central axis of the optical fiber along the length of the optical fiber at a selected pitch resulting in the capability of a fundamental mode beam output for large core sizes. An optical system includes a seed optical source configured to provide a seed beam and an optical amplifier configured to receive and amplify the seed beam. The optical amplifier also includes an active optical fiber having a large mode area non-circular and non-elliptical core rotated about a central axis of said active optical fiber to provide modal discrimination and fundamental mode output.
Patent DK-2963011-T3 (DK)
Inventor: BIENIARZ CHRISTOPHER
IPC: G01N33/532
Filed: 2006-11-21
Granted: 2018-08-06
Abstract: A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays.
Patent DK-0379196-T3 (DK)
Inventor: ARAKAWA SHINICHIRO
IPC: F04D29/44
Filed: 1990-01-18
Granted: 1994-02-07
Abstract: The pump casing is manufactured by press forming of a steel plate and includes a volute casing encircling a pump impeller. The casing has a cylindrical cup shape having open portion at one side and closed bottom portion at other. The volute portion (21a) is radially expanded from cylindrical surface of casing body, at an axially intermediate portion. - There is a casing flange (21B) outwardly extending from the opening portion with an aperture serving as suction port (21d) at bottom portion. The casing is mounted via a cover (22) to the drive shaft bearing (3).
Patent DK-0380331-T3 (DK)
Inventor: KITA TORU
IPC: A61P29/00
Filed: 1990-01-24
Granted: 1994-02-14
Abstract: (Di-tert-butylhydroxyphenyl)thio derivatives of the formula: <CHEM> wherein R is cyano, carbamoyl, or 5-tetrazolyl; n is an integer of 2 to 6; provided that when R is cyano, n is not 2; and pharmaceutically or veterinarily acceptable salts thereof; useful in treating arteriosclerosis, ulcer, inflammation, allergy, or the like.
Patent DK-0392929-T3 (DK)
Inventor: JARRY CHRISTIAN
IPC: A61K31/421
Filed: 1990-04-12
Granted: 1994-04-11
Abstract: 2-Amino-5-aryloxymethyloxazolines of structure 
<IMAGE>
 the aryl group being either a 2-biphenyl, a 3-biphenyl or a 4- biphenyl. The compounds of the invention are useful as drugs.
Patent DK-0451434-T3 (DK)
Inventor: THEVISSEN PETER
IPC: C02F1/44
Filed: 1990-04-13
Granted: 1994-12-05
Abstract: The invention concerns a method for treating water to prevent corrosion and or scaling, characterized in that use is made of carbondioxide as pH regulation, together with one or more of the following components :     a) one or more water soluble polymers   b) one or more water soluble phosphonates c) one or more chemicals capable of preventing corrosion and/or deposits. n
Patent DK-0408742-T3 (DK)
Inventor: EVEN-CHEN ZEEV
IPC: A61K39/29
Filed: 1990-02-07
Granted: 1995-03-20
Abstract: Processes are provided for producing purified, hepatitis B surface antigen particles in mammalian cells which comprise culturing mammalian cells which produce the particles in a culture medium supplemented with a serum free of high molecular weight contaminant proteins and recovering the purified, hepatitis B surface antigen particles. Removal of molecules having a molecular weight greater than about 3 x 10<5> daltons by prefractionation, for example, allows cells to be grown in culture media containing high levels of fetal calf serum, removes high molecular weight contaminant proteins which may be inhibitory to cell growth and simplifies purification of HBsAg since high molecular weight contaminant proteins are the major contaminants removed by purification processes.
Patent DK-0460663-T3 (DK)
Inventor: HOERMANN THOMAS J DIPL-ING
IPC: E05F5/00
Filed: 1991-06-06
Granted: 1995-07-10
Abstract: High-speed doors, especially of multi-leaf design, for fire stations or the like, which are to be opened quickly and independently of mains power supplies under the effect of force accumulators and which, for the purpose of the adjustability of the opening force and therefore selectable opening speed, whilst largely avoiding dependence on the ambient temperature, are so designed that one or more force accumulators are provided, each in the form of a telescopic-tube device, the telescopic parts of which are displaceable in one another counter to the force of a compression spring, especially a helical compression spring.
Patent DK-0504267-T3 (DK)
Inventor: LUXENBERG ROBERT A
IPC: G07C15/00
Filed: 1990-12-10
Granted: 1994-11-28
Abstract: A method of determining the winners of, for example, a game of skill in conjunction with a football or baseball game without the input of all the scores is provided. By the use of statistical sampling a small fraction of the remote players upload their scores to a central station via a telephone line, for example. Then, when the tentative winners are determined from this small statistical sample, the mass communications link of the system downloads the statistical curve to all of the players and only those players who are equal or better than the winning score telephone. Thus, time and money are saved for the telphone up-link. Furthermore, overcrowding of the telephone system is avoided by a proper delay given the individual remote sources.
Patent DK-0584136-T3 (DK)
Inventor: RITZSCHKE OLAF
IPC: C07K16/00
Filed: 1992-05-15
Granted: 2000-05-22
Abstract: PCT No. PCT/EP92/01072 Sec. 371 Date May 9, 1994 Sec. 102(e) Date May 9, 1994 PCT Filed Apr. 15, 1992 PCT Pub. No. WO92/21033 PCT Pub. Date Nov. 26, 1992The present invention concerns a method for the determination of allele-specific peptide motifs on molecules of the major histocompatibility complex (MHC) of classes I and II as well as the peptide motifs which are obtainable by the method according to the invention. In addition the use of the peptide motifs according to the invention for the production of a diagnostic or therapeutic agent is disclosed.
Patent DK-0578982-T3 (DK)
Inventor: WEIDMAN DAVID LEE
IPC: G02B6/28
Filed: 1993-06-16
Granted: 2000-03-20
Abstract: An achromatic fiber optic coupler of the type wherein a plurality of single-mode optical fibers, each having a core and a cladding, are fused together along a portion of the lengths thereof to form a coupling region. The propagation constants of the fibers are preferably equal; however if the fiber claddings have different refractive indices, the lowest cladding refractive index is n2. A matrix glass body of refractive index n3 surrounds the coupling region, n3 being lower than n2 by such an amount that the value of DELTA 2-3 is less than 0.125%, wherein  DELTA 2-3 equals (n2<2><->n3<2>)/2n2<2>. <IMAGE>
Patent DK-0568437-T3 (DK)
Inventor: MAYOL ROBERT F
IPC: A61P25/24
Filed: 1993-04-26
Granted: 2001-04-30
Abstract: Compounds of Formula I <CHEM> or a pharmaceutically acceptable acid addition salt and/or hydrate thereof wherein   R   is halogen and trifluoromethyl; X   is oxygen and acetyl; the single and dotted lines represent either a covalent single or double bond; n   is an integer from 2 to 4; and Z   is hydrogen and <CHEM> in which R<1> is hydrogen, halogen, C1-4 alkoxy and trifluoromethyl, which are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.
Patent DK-0630253-T3 (DK)
Inventor: KROSS ROBERT D
IPC: A61P15/14
Filed: 1993-03-19
Granted: 1999-08-23
Abstract: There is disclosed methods and compositions for preventing and treating bacterial infections, including mastitis, in the udder of a mammal. The compositions include chlorine dioxide in an amount ranging from 5 ppm to 1000 ppm, and have a chlorine dioxide to chlorite ratio of at least 5:1. Methods of the present invention include the infusion of the composition into the mammal's udder, and the formation of the compositions immediately prior to infusion.
Patent DK-0630270-T3 (DK)
Inventor: ZAPOL WARREN M
IPC: B01D53/56
Filed: 1993-03-08
Granted: 2003-06-23
Abstract: A system for producing a mixture comprising nitric oxide and air for treatment of medical conditions. The invention enables unlimited production of nitric oxide at any location using only air and a source of electricity. An electric arc chamber 4 is provided with electrodes 5 separated by an air gap 9. An electric circuit 7 supplies a high voltage potential to the electrodes 5 and induces an electric arc discharge across the electrodes 5. The electric arc discharge produces nitric oxide mixed with air. The mixture of nitric oxide and air is further purified and blended with other gases and/or pulmonary therapeutic agents, and the therapeutically-effective gas mixture is delivered to different organs of a human body using organ specific attachments.
Patent DK-0673333-T3 (DK)
Inventor: JORGENSEN-BECK FRODE
IPC: B65D5/66
Filed: 1993-11-04
Granted: 2001-04-23
Abstract: PCT No. PCT/DK93/00359 Sec. 371 Date Aug. 7, 1995 Sec. 102(e) Date Aug. 7, 1995 PCT Filed Nov. 4, 1993 PCT Pub. No. WO94/10048 PCT Pub. Date May 11, 1994A box is disclosed having a pivot lid and a skirt. The skirt has an internal edge cooperating in a snap locking manner with a folded-over flap at the front edge area of the box mouth. This flap protrudes from an edge area which, as a whole, is resiliently depressible into the box, whereby a snap locking is achieved which will be substantially independent of the manufacturing tolerances of the box. The locking and, in particular, the release of the locking by the opening of the lid will take place in a manner that is very convenient for the user, because the spring action after the release of the locking will contribute to the opening of the lid.
Patent DK-0721346-T3 (DK)
Inventor: NOELLE RANDOLPH J
IPC: A61K35/28
Filed: 1994-09-02
Granted: 1999-03-22
Abstract: Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.
Patent DK-0726920-T3 (DK)
Inventor: FERRUTI PAOLO
IPC: A61K9/16
Filed: 1994-10-28
Granted: 2000-12-18
Abstract: PCT No. PCT/EP94/03560 Sec. 371 Date Jun. 24, 1996 Sec. 102(e) Date Jun. 24, 1996 PCT Filed Oct. 28, 1994 PCT Pub. No. WO95/12629 PCT Pub. Date May 11, 1995Polyesterpolycarbonates of formula (I)   <IMAGE>   wherein a is an integer from 2 to 300; R1 and R2, which can be the same or different, are each a polyester residue of formula (II)   <IMAGE>   with x and y being integers from 0 to 100, and the ratio of (x/x+y)*100 being between 0 and 100, with the proviso that x and y are not 0 at the same time; R3 and R4 being aliphatic hydrocarbon residues of 1 to 4 carbon atoms; R5 being an aliphatic hydrocarbon residue having from 2 to 18 carbon atoms or a cycloaliphatic hydrocarbon residue having from 3 to 8 carbon atoms; or a polyoxyalkylene residue of formula (III):   <IMAGE>   wherein R6 is hydrogen or methyl, n is an integer from 1 to 3 and m is an integer from 1 to 200; and the two -R3-COO and -R4-COO groups are randomly distributed in the polyester residue, with the polyesterpolycarbonates of formula (I) having an intrinsic viscosity of greater than 0.45 dl/g when measured in chloroform at 32 DEG  C. and being useful as bioerosible matrices for the controlled release of drugs.
Patent DK-0736039-T3 (DK)
Inventor: JOHANSEN NILS LANGELAND
IPC: A61P3/00
Filed: 1994-12-22
Granted: 2001-02-12
Abstract: PCT No. PCT/DK94/00485 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Dec. 22, 1994 PCT Pub. No. WO95/17423 PCT Pub. Date Jun. 29, 1995Compounds of the formula A-B-C-D(-E)p are used to stimulate the release of growth hormone from the pituitary.
Patent DK-0758342-T3 (DK)
Inventor: BUSCHMANN ERNST
IPC: C07K7/06
Filed: 1995-04-26
Granted: 2000-05-01
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
Patent DK-0781345-T3 (DK)
Inventor: LESAGE-MEESSEN LAURENCE
IPC: C12P7/42
Filed: 1995-09-13
Granted: 1999-08-23
Abstract: Method for the production of vanillic acid and vanillin by bioconversion from ferulic acid in a medium containing phospholipids cultured with at least one microorganism from the classes Ascomycetes, Basidiomycetes or Actinomycetes. Vanillin is also produced by bioconversion of vanillic acid by at least one microorganism of the class Basidiomycetes in a medium containing cellobiose.
Patent DK-0797909-T3 (DK)
Inventor: MCGRATH PETER THOMAS
IPC: H05K3/38
Filed: 1995-12-12
Granted: 2000-12-18
Abstract: A process for adhering a polymeric material to a metal surface, which process comprises the steps of:   i) treating the metal surface with an adhesion promoting composition comprising 0.1 to 20% by weight hydrogen peroxide, an inorganic acid, an organic corrosion inhibitor and a surfactant in an adhesion promotion step to form a micro-roughened corrosion-coated surface; and ii) adhering a polymeric material to the micro-roughened conversion-coated surface.
Patent DK-0759335-T3 (DK)
Inventor: BREVIERE YANN
IPC: B22D11/12
Filed: 1996-07-25
Granted: 2000-04-25
Abstract: The support, designed for the lateral face of a continuous casting unit with two cooled cylinders (1) having horizontal axes, consists of a carriage (5) which can be moved parallel to the axes of the cylinders and has a thrust member (6) and a panel (4) joined to the lateral face of a cylinder through a thrust plate (8) and thrust elements (9, 9', 9", 9'"). The panel has at least one long bolt (11, 11') which passes through the thrust plate and has its free end equipped with a stop (13, 13') which can be applied against the rear face of the thrust plate. The long bolts can be three in number, distributed over an area corresponding to the shape of the lateral face, and the thrust elements (9, 9', 9", 9'") can be in the for of springs or power cylinders.
Patent DK-0870052-T3 (DK)
Inventor: SHETTY JAYARAMA K
IPC: C07C51/42
Filed: 1996-12-20
Granted: 2005-06-20
Abstract: An enzymatic system comprised of glucose oxidase and a catalase of the same or different sources to result in the complete conversion of glucose to gluconic acid at a glucose concentration greater than 25% (w/w) ds. The resultant gluconic acid, which is essentially free from impurities normally associated with the fermentation process, is then spray granulated to produce a low-dust dry product.
Patent DK-1034124-T3 (DK)
Inventor: HUANG PAO-TER
IPC: G06Q10/04
Filed: 1997-11-21
Granted: 2002-10-14
Abstract: An apparatus for gripping parcels, comprising: a suction holding device (1007) positionable adjacent to an upper surface of a parcel. In one aspect, the apparatus further includes a pair of side clamps (1018) connected by a scissors actuator (1015) mounted for movement with said suction holding device. In another aspect, the apparatus further comprises: means for measuring the height of a parcel; a contact sensor (1027) mounted for movement with said suction holding device; and a controller controlling the lowering of the gripping apparatus and the activation of the suction holding device. <IMAGE>
Patent DK-0957981-T3 (DK)
Inventor: MURDOCK THOMAS O
IPC: A61N1/30
Filed: 1997-12-09
Granted: 2007-09-10
Abstract: A novel electrotransport drug delivery system (10) and therapeutic agent-containing reservoir (26, 28) for use therein are provided. An inert filler material effective to reduce the quantity of therapeutic agent otherwise present is incorporated in the reservoir (26, 28) along with the therapeutic agent to be delivered via electrotransport. Methods for making the reservoir (26, 28) and drug delivery system (10) are provided as well.
Patent DK-0894724-T3 (DK)
Inventor: SJOESTRAND UNO
IPC: B07C5/02
Filed: 1998-07-22
Granted: 2002-10-14
Abstract: The invention relates to a method and an apparatus for detecting toppled packages (2) lying on a conveyor (1). The apparatus includes two pairs of photocells, an upper (4) and a lower (5), disposed as transmitter and receiver of a light beam (6). The photocell pairs (4, 5) are placed on either side of the conveyor path (1) so that the light beam (6) bisects the conveyor path (1) at a certain angle. The apparatus also includes a magnet valve (16) and a device (1) for removing a toppled package (2). The lower photocell pair (5) transmits, when the light beam (6) is broken, a signal to the upper photocell pair (4) which, when the light beam (6) is unbroken, transmits a signal to the magnet valve (16). The magnet valve (16) activates the device (10) which, for example, consists of an air nozzle (11), so that the toppled package (2) is blown off from the conveyor (1). <IMAGE>
Patent DK-0924146-T3 (DK)
Inventor: VIEREGGE GERHARD
IPC: B65G7/04
Filed: 1998-12-15
Granted: 2002-09-02
Abstract: At least two rolling members (3) are provided to support the load (2), each having several rollers (5) to give a relatively large area of surface contact. Preferably the rollers are elongated or each rolling member comprises several adjacent rollers or wheels. They may be mounted on a support frame (4)
Patent DK-0922489-T3 (DK)
Inventor: CARLSSON MATS
IPC: B01D15/18
Filed: 1992-04-16
Granted: 2003-03-24
Abstract: Use of beads for recovering a desired component from a sample solution, the beads:     having affinity for the component, comprising a polymer matrix into which glass or silica particles are incorporated, and being fluidised in a column in an upward-flowing liquid stream comprising the sample solution.
Patent DK-0978506-T3 (DK)
Inventor: OTA TOMOMI TAISHO PHARMACEUTIC
IPC: C07C225/22
Filed: 1998-03-26
Granted: 2003-02-24
Abstract: A 2-phenoxyaniline derivative represented by the formula: <CHEM> wherein R<1> is a hydrogen atom, an amino group or an NHCOR<3> group, R<2> is a halogen atom, an amino group, a cyano group, a C1-6 alkyl group, a C1-3 perfluoroalkyl group, an NHCOR<3> group, a CH2OR<4> group, an OCH2R<5> group or a COR<6> group, R<3> is a C1-6 alkyl group, R<4> is a hydrogen atom or a C1-6 alkyl group, R<5> is a hydrogen atom, a C1-6 alkyl group, a C1-5 aminoalkyl group, a C2-7 alkoxycarbonyl group or a carbamoyl group, and R<6> is a C1-6 alkyl group or a C3-8 cycloalkyl group which is unsubstituted or substituted by a halogen atom, an amino group, a cyano group or a straight or branched C1-6 alkyl group; or a pharmaceutically acceptable salt thereof.
Patent DK-1066963-T3 (DK)
Inventor: KUHN FEDERICO
IPC: B41F13/30
Filed: 1999-07-09
Granted: 2003-04-28
Abstract: The distance-adjusting device has displaceable sliding elements (4, 5) on the tool holder (2') of one or of the middle tool which run in guides, without having a detrimental effect on the tools. One end of each sliding element is configured as a counter-stop surface to stop surfaces (1", 3") which are located on the neighbouring tool holders, whilst an adjusting drive (13) acts upon the other end of each sliding element. The distance between neighbouring tools can thus be adjusted to optimal values.
Patent DK-1006691-T3 (DK)
Inventor: KESSLER MICHAEL
IPC: H04L29/06
Filed: 1999-10-13
Granted: 2005-08-15
Abstract: In a first phase, an identification phase, communication and data structure on a bus are observed and the type of protocol in use is determined. Data messages are received and their characteristics analyzed. In a subsequent communication phase, communication with the transmitting station and/or data evaluation using the identified protocol and/or via the identified interface is performed. In the identification phase, the physical interface for performing communication is determined and this interface is used in the communication phase.  An apparatus for performing the method is also claimed.
Patent DK-1051495-T3 (DK)
Inventor: MORRIS PETER
IPC: C12N15/11
Filed: 1999-02-03
Granted: 2006-05-22
Abstract: The present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides. Further, nucleic acid molecules are provided, which encode these mistletoe lectin polypeptides, and also pharmaceutical compositions comprising mistletoe lectin nucleic acids. The present invention also relates to isolated mistletoe lectin polypeptides and pharmaceutical compositions comprising said polypeptides.
Patent DK-1064303-T3 (DK)
Inventor: MURPHY GERALD P
IPC: A61P35/00
Filed: 1999-03-18
Granted: 2007-09-17
Abstract: The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.