baber/WOPTO huggingface dataset:
Patent EA-021389-B1 (EA)
Title: Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers
Inventor: GIORDANO CLAUDIO
IPC: C07C309/04
Filed: 2011-04-06
Abstract: The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy)benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methanesulfonic acid in high yields and very high enantiomeric and chemical purity in the form of the crystalline anhydrous polymorph identified as form A, wherein said salt is substantially free from impurities having genotoxic effect, such as (C-C)alkanylmethanesulfonates, and residual solvents known as potential precursors thereof, such as (C-C)alkanols or esters thereof with lower alkanoic acids. The process foresees: (i) production and/or crystallization of the salt, from water, acetone, an aliphatic ketone of 4-5 carbon atoms or mixtures thereof with water, or (ii) slurring the solid salt with (a) water, (b) a mixture of water with acetone or an aliphatic ketone of 4-5 carbon atoms, (c) acetone, an aliphatic ketone of 4-5 carbon atoms or a mixture thereof, or (iii) exposure of the solid salt to air stream having high degree of relative humidity, and, when the obtained product consists as a whole or in part of crystalline hemihydrate pseudopolymorph form H crystals, converting said product into anhydrous form A crystals by submitting it to water removal. The crystalline hemihydrate pseudopolymorph form H of ralfinamide methanesulfonate, or its R-enantiomer, is a useful intermediate for obtaining the crystalline anhydrous polymorph A free from the above impurities having genotoxic effect and/or residual solvents known as precursors thereof, and exhibits a physicochemical profile conferring significant advantages in the design and development of solid dosage forms, in particular, of modified release formulations.
Patent EA-030434-B1 (EA)
Title: Method of improving the production of a mature gas or oil field
Inventor: OURY JEAN-MARC
IPC: E21B43/30
Filed: 2011-06-15
Abstract: A method of improving the production of a mature gas or oil field, said field comprising a plurality of existing wells, said method comprising providing a field simulator capable of predicting a production of said field in function of a given scenario, a scenario being a set of data comprising production parameters of the existing wells and, the case may be, location and production parameters of one or more new wells, determining drainage areas of said existing wells using the field simulator, determining locations of candidate new wells such that drainage areas of said candidate new wells, determined using the field simulator, do not overlap with the drainage areas of the existing wells, optimizing the value of a gain function which depends on the field production by determining a set of wells out of a plurality of sets of wells, which optimize the value of said gain function, each set of wells of said plurality of sets of wells comprising the existing wells and new wells selected among the candidate new wells.
Patent EA-023335-B1 (EA)
Title: Tire for a trailer type heavy vehicle
Inventor: BECHON HERVE
IPC: B60C11/03
Filed: 2011-11-24
Abstract: The invention relates to a tire (1) intended to equip a trailer type heavy vehicle, wherein said tire (1) includes a carcass reinforcement (2) on which a cap reinforcement (3) is mounted radially on the outside, said cap reinforcement comprising at least two working plies (31, 32), the width Lt of said cap reinforcement being equal to the width of the axially narrowest working ply, a tread ("cap") (10) being mounted on said cap reinforcement (3) radially on the outside, and said cap reinforcement being interleaved radially between said tread and the cap reinforcement by a sublayer ("base") (6), said sublayer extending axially and radially under the entire tread and radially outside the cap reinforcement (3) over a total width at least equal to the width Lt of the cap reinforcement, an equatorial plane axially dividing the tread into an outer half-tread (TE) and an inner half-tread (TI); having the same axial width, the outer half-tread (TE) being intended to be axially positioned toward the outside of a vehicle and the inner half-tread (TI) being intended to be axially positioned toward the inside of a vehicle, said tire being such that the sublayer (6) includes an additional volume (6-A) placed radially below the inner half-tread (TI), said additional volume being such that the volume occupied by the sublayer radially below the inner half-tread (TI) is greater than the volume occupied by the sublayer radially below the outer half-tread (TE), and said tire being such that the material constituting the sublayer (6) is a rubber-based composition having a hysteresis lower than the hysteresis of the rubber-based material constituting the tread (10).
Patent EA-026847-B1 (EA)
Title: C4-monomethyl triterpenoid derivatives and methods of use thereof
Inventor: ANDERSON ERIC
IPC: C07J63/00
Filed: 2012-03-09
Abstract: Disclosed herein are novel C4-monomethyl triterpenoid compounds and derivatives thereof, including those of the formulawherein the variables are defined herein. The present invention also relates to pharmaceutical compositions comprising such compounds and to the use of the claimed compounds in the manufacture of a medicament for treating and/or preventing a disease or a disorder associated with oxidative stress and inflammation in a patient in need thereof.
Patent EA-027202-B1 (EA)
Title: Improved process for the preparation of treprostinil and derivatives thereof
Inventor: JAIN NARESHKUMAR F
IPC: C12P41/00
Filed: 2013-05-22
Abstract: An improved method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.
Patent EA-028228-B1 (EA)
Title: Endopeptidase composition hydrolyzing gluten oligopeptides, process for producing same and use
Inventor: CAVALETTI LINDA
IPC: C12N9/52
Filed: 2012-11-05
Abstract: The invention relates to an endopeptidase composition able to hydrolyze gluten oligopeptides, to an isolated endopeptidase of the S8/S53 family, to the use thereof for the treatment or prevention of celiac sprue, dermatitis herpetiformis and any other disorder associated with gluten intolerance, to the use thereof for producing food protein hydrolysates in the manufacture of food supplements and for the treatment of liquid food supplements; the invention also relates to a food supplement comprising the claimed endopeptidase composition or endopeptidase; to an isolated nucleic acid encoding the claimed endopeptidase; to processes for producing the claimed endopeptidase composition; to a method of the degradation of gluten oligopolypeptides.
Patent EA-030404-B1 (EA)
Title: Flap modulators
Inventor: ECCLES WENDY
IPC: C07D237/20
Filed: 2014-01-31
Abstract: The present invention relates to compounds of Formula (I)or a form thereof, wherein ring A, R, L and Rare as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Patent EA-029654-B1 (EA)
Title: Low-emissivity glazing
Inventor: BAUDOUIN ANNE-CHRISTINE
IPC: C03C17/36
Filed: 2014-05-28
Abstract: The invention relates to low-emissivity glazing units that are capable of undergoing a heat treatment and only change very little in properties when they are subjected to such a heat treatment. They comprise a transparent substrate provided with a stack of thin layers of the type: first dielectric coating/infrared radiation reflecting functional layer/barrier layer/second dielectric coating. They are characterised by a first dielectric coating comprising a layer made from an oxide, in direct contact with the substrate, by a barrier layer based on zinc oxide or consisting of an indium oxide possibly doped with tin, and by a second dielectric coating comprising, in order, a layer made from an oxide other than silicon oxide with a thickness greater than 5 nm and a layer made from a silicon nitride or a silicon oxide with a thickness greater than 10 nm.
Patent EA-037895-B1 (EA)
Title: Solid pharmaceutical compositions of androgen receptor antagonists
Inventor: GRAHEK ROK
IPC: A61K31/4439
Filed: 2015-02-04
Abstract: The invention belongs to the field of pharmaceutical industry and relates to solid pharmaceutical compositions comprising androgen receptor antagonists, e.g. Enzalutamide or ARN-509, as well as to processes for preparing these compositions. The solid pharmaceutical compositions of the invention are useful in the treatment of prostate cancer.
Patent EA-033794-B1 (EA)
Title: Electronic cigarette
Inventor: LOUVEAU ERIC
IPC: A24F40/50
Filed: 2015-02-20
Abstract: An electronic cigarette (1) comprising a heating element (10) able to vapourize a substrate during a smoking period, characterized in that it includes means (30) for measuring an approximation (ΔU10(t), U10(t)) of a characteristic of the voltage (U10(t)) across the terminals of the heating element (10) during the smoking period, said approximation being measured across the terminals (B1, B2) of a circuit (500), no component of which exhibits intrinsic characteristics not disturbed by the inhalations; means (30) of estimating an approximation (ΔU10(t), U10(t)) of said characteristic of the voltage (U10(t)) across the terminals of the heating element (10) in the absence of inhalation during said smoking period; means (30) of calculating an intensity (F) representative of the intensity of the inhalations during said smoking period on the basis of an integration of the difference between said approximations during said smoking period; and means (30) of estimating the said quantity of substrate vapourized by the heating element at least on the basis of said intensity.
Patent EA-035064-B1 (EA)
Title: Layered coding and data structure for compressed higher-order ambisonics sound or sound field representations
Inventor: KORDON SVEN
IPC: G10L19/008
Filed: 2016-10-07
Abstract: The present invention relates to a method and an apparatus for decoding a compressed Higher Order Ambisonics (HOA) representation of a sound or sound field. The compressed HOA representation comprises a plurality of transport signals. The method comprises the steps of receiving a bit stream containing the compressed HOA representation corresponding to a plurality of hierarchical layers that include a base layer and two or more hierarchical enhancement layers, wherein the bit stream comprises, for each layer, a respective HOA extension payload including side information for parametrically enhancing a reconstructed HOA representation obtainable from the transport signals assigned to the respective layer and any layers lower than the respective layer; determining a highest usable layer among the plurality of layers for decoding, wherein the highest usable layer is the layer lower than a lowest layer that has not been validly received; extracting a HOA extension payload assigned to the highest usable layer, wherein the HOA extension payload includes side information for parametrically enhancing a reconstructed HOA representation corresponding to the highest usable layer, wherein the reconstructed HOA representation corresponding to the highest usable layer is obtainable on the basis of the transport signals assigned to the highest usable layer and any layers lower than the highest usable layer; decoding the compressed HOA representation corresponding to the highest usable layer based on layer information, the transport signals assigned to the highest usable layer and any layers lower than the highest usable layer; and parametrically enhancing the decoded HOA representation using the side information included in the HOA extension payload assigned to the highest usable layer. The technical result consists, at least, in enhancing sound quality at low bitrates.
Patent EA-038098-B1 (EA)
Title: Tetracyclic pyridone compounds as antivirals
Inventor: FU JIPING
IPC: C07D217/08
Filed: 2017-02-16
Abstract: The invention relates to compounds of Formula (I)as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.
Patent EA-036470-B1 (EA)
Title: Delivery device for liquid pharmaceuticals
Inventor: BILGIC MAHMUT
IPC: A61M5/315
Filed: 2017-02-17
Abstract: The present invention proposes a liquid pharmaceuticals delivery device (18) comprising a mainly cylindrical main body (1), a cartridge (3) having a mainly cylindrical inner cavity with a volumetric capacity for accommodating multiple doses of a liquid pharmaceutical, the cartridge (3) comprising a first end for receiving a plunger (7) and a second end for liquid pharmaceutical extraction. The device (18) further comprises a jackscrew (55) a comprising a threaded lower jackscrew (5) and a threaded upper jackscrew (6) integrated or fixed to each other. The jackscrew (55) being rotatable around a primary axis of the main body (1) and stationary along said primary axis, a threaded plunger rod (8) which is integrated to the plunger (7) and which has a thread diameter (Dp) corresponding to thread diameter of the lower jackscrew (5). A button (12) is engageable with the spindle (10), by one thereof having a recess and the other having a protrusion matching said recess along a direction parallel to the primary axis of the spindle (10). The threaded mainly cylindrical spindle (10) has a thread diameter (Ds) corresponding to thread diameter of the upper jackscrew (6). The thread diameter (Ds) of the spindle (10) is greater than the thread diameter (Dp) of the plunger rod (8).
Patent ES-2172401-B1 (ES)
Title: Procedimiento para la obtencion de un compuesto quimico en polvo, aplicable como mortero con la adicion de agua.
Inventor: MEGINO HOFFMAN JORG
IPC: C04B26/02
Filed: 2000-05-26
Granted: 2003-12-16
Abstract: Se describe un procedimiento para la obtención de un compuesto químico en polvo, susceptible de aplicación como mortero, al añadirle agua, sobre cualquier superficie, consistente en mezclar caucho vulcanizado, aglutinante orgánico, ignifugante-retardante, modificantes, estabilizantes y colorantes, en un mezclador de sólidos herméticamente cerrado, molerlo en un molino de martillos, combinado con bolas de acero, herméticamente cerrado, cribarlo obteniendo polvo fino de granulometría requerida, almacenarlo en un silo cerrado herméticamente y con atmósfera de un gas protector en su interior, para aislarlo del contacto del aire y preservarlo de la humedad, envasarlo en envases definitivos para su expedición, y en el momento de obtener el mortero terminado añadirle agua.
Patent ES-2190383-B1 (ES)
Title: Extracto de vitex agnus castus.
Inventor: CORLEY DAVID GREGORY
IPC: A23L33/15
Filed: 2002-05-09
Granted: 2004-10-16
Abstract: Extracto de Vitex agnus castus obtenible mediante extracción de los frutos secos y pulverizados de la planta Vitex agnus castus con un disolvente de etanol al 90-100%, separación de la solución de extracción del resto del material vegetal, separación del disolvente de la solución de extracción y recuperación del extracto. También se proporciona un suplemento dietético que comprende un extracto de Vitex agnus castus que tiene un contenido en ácido linoléico de al menos 10% en peso y una fuente de calcio, así como el uso del extracto y del suplemento dietético para tratar estados que afectan particularmente a las mujeres.
Patent ES-2222070-B1 (ES)
Title: Fuente de energia electrica autorecargable.
Inventor: KONJEVIC LISAC BOZIDAR
IPC: H02M3/24
Filed: 2002-07-16
Granted: 2006-04-01
Abstract: Fuente de energía eléctrica autorrecargable. La corriente eléctrica que circula desde la batería (UB) a través del motor eléctrico (M) y el diodo (D1) carga a los condensadores (CA) y (CB) unidos en paralelo, que una vez cargados se conectan en serie originando una diferencia de tensión con respecto a la batería, provocando que la mitad de la carga de los condensadores sea devuelta a través del diodo D2 a la batería, mientras que con una nueva conexión en paralelo los condensadores se vuelven a cargar, siendo esta carga igual a la que previamente se había trasladado desde los condensadores a la batería, de manera que mediante la conexión cíclica de los condensadores en paralelo y serie, la energía se traslada desde la batería a los condensadores y desde los condensadores a la batería, prolongando considerablemente la autonomía de la batería y el funcionamiento del motor.
Patent ES-2223253-B1 (ES)
Title: Banco de ensayo dinamico de neumaticos de superficie plana.
Inventor: SIMON MATA ANTONIO
IPC: G01M17/02
Filed: 2002-12-12
Granted: 2006-02-01
Abstract: Banco de ensayo dinámico de neumáticos de superficie plana, el cual permite simular y estudiar el comportamiento dinámico del neumático en condiciones operativas controlables y repetitivas en laboratorio. El banco se compone de una estructura rígida que sustenta el cabezal de transmisión de movimientos al neumático (ángulo de caída y deriva y desplazamiento vertical) y una banda de rodadura flexible de acero inoxidable, sobre la que se apoya el neumático, esta banda gira mediante unos tambores, uno fijo y otro móvil, con un sistema para la corrección de la banda, que evita la salida de está, el carro que soporta la banda está apoyado sobre unas guías lineales permitiendo el movimiento lateral, con lo cual sobre el neumático se pueden aplicar unas cargas verticales y laterales variables con el tiempo. El sistema también es capaz de controlar los movimientos y leer de los distintos sensores, a través de un computador central, que además hace de interfaz con el usuario.
Patent ES-2222085-B1 (ES)
Title: Producto alimenticio a base de vegetales adicionado con carnes y pescados.
Inventor: GUISASOLA GONITI MANUEL
IPC: A23L13/60
Filed: 2003-05-12
Granted: 2006-03-01
Abstract: Producto alimenticio a base de vegetales adicionado con carnes y pescados que consiste en la incorporación previamente limpios la carne y el pescado en un 80% de forma independiente a los cuales se adiciona un 20% de productos vegetales, igualmente limpios, incorporándose el conjunto en una mezcladora o trituradora industrial, adicionándose especias y aditivos y posteriormente configurándose con la mezcla obtenida una forma acorde con la presentación establecida.
Patent ES-2255863-B1 (ES)
Title: Sistema de montaje de armarios bajos de cocina.
Inventor: SANTOS CASTRO JOSE ANTONIO
IPC: A47B77/02
Filed: 2004-12-29
Granted: 2007-08-01
Abstract: Sistema de montaje de armarios bajos de cocina, adosados a una pared, que comprende las etapas de: a) fijar una serie de rastreles (1, 2 y 3) sobre la pared y piso; b) posicionar y fijar entre estos rastreles una serie de montantes verticales (13 y 14); c) posicionar y fijar sobre el canto superior horizontal de los montantes una encimera (20); d) montar sobre los cantos anteriores de los montantes (14) puertas y paneles de cierre.
Patent ES-2291117-B1 (ES)
Title: Sistema de medicion de la resistencia de liquidos y suelo.
Inventor: SHUKHOSTANOV VLADIMIR
IPC: G01N27/02
Filed: 2006-04-25
Granted: 2009-01-01
Abstract: Sistema de medición de la resistencia de líquidos y suelo. El sistema está previsto para la medición de la resistencia específica de líquidos y del suelo basándose en la combinación funcional de una célula conductométrica (1) y un bloque de medición que comprende un generador de impulsos rectangulares (2), un medidor-divisor de frecuencia (3), un inversor (4), una fuente de corriente de soporte (5), un conmutador puente de medición de corriente (6), un conmutador puente de medición de tensión (7) y un medidor de tensión continua (8), estando los conmutadores puente tanto de corriente como de tensión, conectados con los correspondientes electrodos de la célula conductométrica (1) mientras que el resto de bloques están convenientemente conectados como se representa en la figura 1.
Patent ES-2315141-B1 (ES)
Title: Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
Inventor: VICIOSO SANCHEZ MERCEDES
IPC: A61K31/4184
Filed: 2006-11-23
Granted: 2009-12-22
Abstract: Procedimiento para la preparación de candesartán
cilexetilo en forma cristalina. 
     Se describe un procedimiento para la preparación
de una forma cristalina  de candesartán cilexetilo denominada forma
I que tiene un contenido de  la denominada forma II inferior al 1%
en peso. Dicho procedimiento comprende  una etapa de siembra con un
producto cristalino que comprende una proporción  mayoritaria de la
forma I, y una etapa de digestión. La invención también  se refiere
a dicha forma cristalina, a las composiciones farmacéuticas  que la
contienen, y a su uso para la preparación de un medicamento para  el
tratamiento de la hipertensión. Se ha observado que el candesartán
cilexetilo  forma I presenta una buena estabilidad cuando se
mantiene en condiciones  de estabilidad acelerada si presenta un
contenido de la forma II inferior  al 1 % en peso.
Patent ES-2324508-B1 (ES)
Title: Mejora del contenido aromatico de vinos y otras bebidas alcoholicas mediante la utilizacion de microorganismos que, durante la fermentacion, producen monoterpeno sintasas.
Inventor: OREJAS SUAREZ MARGARITA
IPC: C12G1/022
Filed: 2006-12-27
Granted: 2010-05-31
Abstract: Mejora del contenido aromático de vinos y otras
bebidas alcohólicas mediante  la utilización de microorganismos que,
durante la fermentación, producen  monoterpeno sintasas. 
     La presente invención describe un nuevo
procedimiento para elaborar bebidas  alcohólicas con mayor y/o
diferente contenido terpénico, mediante la utilización  de
microorganismos manipulados genéticamente para que expresen durante 
la fermentación genes que codifican monoterpeno sintasas (a veces
llamadas  monoterpeno ciclasas), lo que les capacita para producir
de novo monoterpenos  aromáticos a partir de cualquier material
vegetal de partida. Los microorganismos  son transformados con el
gen Lis, que codifica una linalol sintasa, incrementándose  la
secreción de linalol, como ejemplo de una familia extensa de genes
que  codifican monoterpeno sintasas. 
     Aunque los microorganismos serán preferentemente
levaduras de la especie   Saccharomyces cerevisiae , también
sería aplicable a otros microorganismos  de interés enológico tales
como otras levaduras y ciertas bacterias. En  particular, bebidas
alcohólicas fermentadas tales como vinos, incluidos  cava y
champagne, cerveza, sidra, sake, etc. podrán tener un aroma más 
favorable o diferente.
Patent ES-2294973-B1 (ES)
Title: Tapon.
Inventor: BADIA INIESTA ANTONIO
IPC: B65D41/34
Filed: 2007-09-24
Granted: 2008-11-16
Abstract: Tapón para botella contenedora de líquidos, del tipo que presenta un cuerpo único realizado en material plástico, acoplable de un modo fijo al gollete de la botella, presentando asimismo el tapón un precinto perimetral desgarrable de tal manera que, una vez desgarrado el precinto, el tapón presenta una zona fijada al gollete y una zona de tapa que permite abrir y cerrar el tapón, presentando asimismo el precinto desgarrable, en uno de sus extremos, una pestaña de mayor anchura que el resto del precinto desgarrable, parcialmente separada del resto del tapón para facilitar el desgarro del precinto, caracterizado porque la pestaña se extiende, integrándose con la superficie lateral del tapón, sin sobresalir de ésta, hasta la superficie superior de la parte de tapa del tapón, quedando enrasada con ésta y porque la citada superficie superior presenta una ranura adyacente a la pestaña para permitir el desgarro del precinto empezando por la pestaña.