baber/WOPTO huggingface dataset:
Patent JP-2000511273-A (JP)
IPC: B01D53/44
Filed: 1997-05-20
Abstract: Regenerative thermal oxidizer in which a gas such as contaminated air is first passed through a hot heat-exchange bed and into a communicating high temperature oxidation (combustion) chamber, and then through a relatively cool second heat exchange bed. The apparatus includes a number of internally insulated, ceramic filled heat recovery columns topped by an internally insulated combustion chamber. Process air is fed into the oxidizer through an inlet manifold containing a number of hydraulically or pneumatically operated flow control valves (such as poppet valves). The air is then directed into the heat exchange media which contains "stored" heat from the previous recovery cycle. The process air is heated to near oxidation temperatures. Oxidation is completed as the flow passes through the combustion chamber, where one or more burners are located. The gas is maintained at the operating temperature for an amount of time sufficient for completing destruction of the VOC's. From the combustion chamber, the gas flows vertically downward through another column containing heat exchange media, thereby storing heat in the media for use in a subsequent inlet cycle when the flow control valves reverse. The resulting clean air is directed via an outlet valve through an outlet manifold and released to atmosphere at a slightly higher temperature than inlet, or is recirculated back to the oxidizer inlet. An integrated VOC entrapment chamber entraps any VOC's that leak out during cycling, and recycles them back to the oxidizer inlet for further processing.
Patent JP-2001519067-A (JP)
Title: ミラー保護されたウェブ・サイトに関するユーザ・ヒットをリモート・サイト運営管理者に提供する方法および装置
IPC: H04N7/16
Filed: 1998-04-09
Abstract: (57)【要約】
ミラー保護されたサイトの運営管理者（４８０）に、プロキシの文書キャッシュ（４６５）からのヒット数を提供し、プロキシ（４１０）内で文書要求をディスパッチして、当該プロキシ（４１０）内部において文書キャッシュ空間（４６５）を一層効率的に割り当てる方法および装置を開示する。プロキシ（４１０）は、最後に要求された文書を記憶する文書キャッシュ（４６５）を含み、要求文書のユニフォーム・リソース・ロケータ（ＵＲＬ）や、キャッシュからの応答回数のような、プロキシの文書キャッシュ（４６５）が処理したクライアント（１）からの要求に関する情報を維持する。この情報は、プロキシ（４１０）によってリモート・サイト運営管理者（４８０）に提供される。このようにして、リモート・サイト運営管理者（４８０）は、全ヒットを一層精度高く追跡することが可能となる。本発明の他の態様によれば、プロキシ（４１０）は、クライアント要求に対するディスパッチ方式を実施し、その結果、プロキシの文書キャッシュ空間（４６５）の割り当てが一層効率的となる。
Patent JP-2001524212-A (JP)
Title: 一括組立の半導体薄膜圧力センサおよびその製造方法
IPC: G01L9/00
Filed: 1998-03-24
Abstract: (57)【要約】
空気流からの圧力など外力によって動かされる可撓性膜を有する圧力センサ。この可撓性膜は開口を有する半導体フレームを跨いで延び、その一部が前記半導体フレーム全体を跨いで延び、またその一部が前記開口を跨いで延びる形になっている。膜には固有の引張応力がかかっている。前記開口を跨いで延びる前記膜部分を覆って一つ以上の歪みゲージ抵抗器を形成する。この膜は外部からかかる圧力に応じて変形する。膜の変形に伴って歪みゲージ抵抗器が長くなり、それら抵抗器の抵抗値を大きくする。この抵抗値変化を測定し、外部圧力の大きさの算定に用いる。一つの実施例では、歪みゲージ抵抗器の抵抗値変化を電位差に変換するのにホイートストンブリッジ回路を用いている。
Patent JP-2002500758-A (JP)
Title: コロニー形成因子の質量分析法
IPC: C07K14/245
Filed: 1998-05-01
Abstract: (57)【要約】
本発明は、Escherichia coliのサンプルにおいて特定のコロニー形成因子（例えば、線毛、原線維、またはピリ線毛）を同定するための質量分析法の使用に関する。このサンプルは、1,1,1,3,3,3,-ヘキサフルオロ-2-プロパノールに溶解させた後に質量分析法による分析をする。この方法は、特定の生物により産生されるコロニー形成因子を差別的に同定することにより感染を追跡するのに有用である。
Patent JP-2001527569-A (JP)
IPC: A61P35/00
Filed: 1998-05-26
Abstract: The invention provides compositions comprising uscharin and the use of uscharin to combat cell proliferation for example in the treatment of cancer. Administration of uscharin may kill or reduce the growth rate of cancer cells and may also be of application in other medical conditions presenting symptoms of excessive or uncontrolled cell proliferation. The composition may be administered by any convenient route and formulated accordingly. The composition may be administered locally or generally and may be suitably dissolved and/or suspended in a pharmaceutically acceptable liquid carrier medium.
Patent NZ-198499-A (NZ)
Title: Control of fluidised bed furnace temperature:inert gas and steam mixed with combustion air
Inventor: CAPLIN P B
IPC: F27B15/18
Filed: 1981-09-30
Abstract: The specification describes arrangements in which the attemperation or control of the temperature of a fluidised bed (13) in a fluidised bed combustion unit (10) effected by means of the mixture of a variable porportion of inert gas with fluidising air fed to the bed (13) may be supplemented with steam. Supplementation with steam being effected to a relatively minor extent during normal operation of the unit but being effected to a major extent when the temperature of the bed passes outside the range at which attemperation may be effected by use of recycled flue gas. The combustion unit (10) is described in use within an arrangement including process plant (12) in the form of a rotary drum dryer.
Patent NZ-205816-A (NZ)
Title: By-pass vacuum cleaner with sound-absorbing material in air outlet
Inventor: BERFIELD R C
IPC: A47L9/00
Filed: 1983-09-29
Abstract: A noise muffler for a vacuum cleaner 10 is constructed of flexible open cell foam inserts 86, 87, one of which 87 extends across an opening 89 through which working air flows between two plenums 90 91. At this opening 89 the foam inserts 87 is provided with a plurality of relatively large perforations 83. Similar perforations 79 may be provided at the ends 78 of the other insert 86, this other insert 86 being in the downstream plenum 90.
Patent NZ-207824-A (NZ)
Title: Inhibiting or reducing sweetness using phenylalkanoic acid derivatives
Inventor: LINDLEY M G
IPC: A23L27/20
Filed: 1984-04-12
Abstract: The sweetness of an ingestible product containing a sweetening sugar or sugar alcohol in large quantities can be reduced by incorporating therein a sweetness-reducing amount of at least one compound of the general formula:   <IMAGE> (I)  in which m represents 0 or 1, and when m represents 0, n represents 1, 2 or 3, and p represents 1, 2, 3 or 4, and when m represents 1, n represents 1 or 2 and p represents 0, 1, 2, 3 or 4; the substituents R, which may be the same or different, each represent a lower alkoxy group, e.g. with 1 to 5 carbon atoms, phenoxy group or a lower alkyl or trifluoromethyl group; and/or two substituents R together represent an aliphatic chain linked to the phenyl ring at two positions, either directly or via an oxa-group, e.g. an alkylenedioxy, alkenylenedioxy, alkylenoxy or alkenylenoxy group; and/or one substituent R represents a hydroxy group while at least one other substituent R represents an alkoxy group; and X+ represents a physiologically acceptable cation.
Patent NZ-220078-A (NZ)
Title: Tyre reinforcement: cylindrical zig-zag winding of continuous cord laid over toroidal core
Inventor: LAURENT D
IPC: B29D30/34
Filed: 1987-04-23
Abstract: The manufacture of a reinforcement for a tire comprises the following steps: (a) a continuous cord is hooked to retention means disposed in two circles which are a distance apart which corresponds to the length of the path of a cord from one side of the reinforcement to the other so that the cord, disposed in this way, defines a cylinder by a plurality of passes back and forth from one retention means to another, (b) by a suitable movement of the retention means, the cord which is disposed in this way is folded back on and around a core defining the shape of the inner surface of the tire, (c) the anchoring of the cord being assured, the retention means are released.
Patent NZ-220292-A (NZ)
Title: Six-layer shrink film containing ethylene alkyl acrylate
Inventor: OBERLE T T
IPC: B65D65/40
Filed: 1987-05-13
Abstract: A pasteurizable and/or cook-in shrink film is provided with good interlaminar adhesion and good orientability, and characterized by the presence of ethylene alkyl acrylate copolymer in shrink and abuse layers, in adhesive layers, or both. An associated method for making the film is also provided that includes coextrusion of the multilayer film, optional irradiation, and orientation.
Patent NZ-235814-A (NZ)
Title: Hydrogel wound dressing product
Inventor: CARTMELL JAMES V
IPC: C08G18/75
Filed: 1990-10-24
Abstract: A wound dressing product (10) includes a flexible backing member (14) which is vacuum formed to include a depression (38). A pressure-sensitive adhesive layer (16) extends across the depression (38) side of the flexible backing member (14). A hydrogel material (12) is positioned in the depression (38) of the flexible backing member (14) and a release liner (18) extends over the exposed pressure-sensitive adhesive layer (16) and the exposed hydrogel material (12) . The release liner (18) has a selective releasability whereby it can be removed from the wound dressing, product (10) intact, leaving a portion-of the pressure-sensitive adhesive (16) and the hydrogel material (12) exposed.
Patent NZ-243191-A (NZ)
Title: Aminomethyl substituted 2,3-dihydropyrano[2,3-b]pyridine derivatives and medicaments containing them
Inventor: ARLT DIETER
IPC: A61P43/00
Filed: 1992-06-18
Abstract: Aminomethyl-substituted 2,3-dihydropyrano[2,3-b]pyridines can be prepared by alkylation of corresponding amines. The novel aminomethyl-substituted dihydropyrano[2,3-b]pyridines can be used as active ingredients in medicaments, in particular for the treatment of disorders of the central nervous system.
Patent NZ-260139-A (NZ)
Title: Reclining chair; method of assembling chair using modular components and chair so assembled
Inventor: LAPOINTE LARRY PATRICK
IPC: A47C1/035
Filed: 1994-03-21
Abstract: A modular reclining chair and method for assembling it are disclosed. The modular reclining chair includes a simplified actuation mechanism which significantly reduces system complexity and weight while providing improved comfort to the seat occupant. The construction is such that the pre-assembled actuation mechanism is integrally suspended from and interdependent with modular frame components, and included among the modular frame components is a front cross rail assembly. <IMAGE>
Patent NZ-264115-A (NZ)
Title: Tricyclic diazepine derivatives, analogues, and medicaments
Inventor: ALBRIGHT JAY DONALD
IPC: A61K31/395
Filed: 1994-07-28
Abstract: Tricyclic diazepine derivs. of formula (I) and their pharmaceutically acceptable salts, esters and pro-drugs are new. Y = (CH2)n, CH(1-3 C alkyl) or CO; AB = (CH2)mN(R3) or N(R3)(CH2)m ; n = 0-2; m = 1-2; provided that when Y = (CH2)n and n = 2, m may also be 0, and when n = 0, m may also be 3, provided also that when Y = (CH2)n and n = 2, m is not 2; R3 = COAr; Ar = substd. phenyl; opt. N-substd. indole; or opt. substd. furan, thiophene or pyrrole; D, E, F = C or N, any C atoms being opt. substd.; Z is such that the ring contg. it = opt. substd. fused phenyl; 5-membered aromatic, opt. satd. ring contg. one of O, N and S; 6-membered aromatic, opt. satd. ring contg. one N; 5- or 6-membered aromatic, opt. satd. ring contg. two N; or 5-membered aromatic, opt. satd. ring contg. one N, and either one O or one S; the heterocyclic rings are opt. substd.
Patent NZ-276915-A (NZ)
Title: Extruded synthetic wood products; apparatus and process in which organic fibrous material is combined with thermoplastics material to form a composite
Inventor: LAVER TERRY CHARLES
IPC: B29C48/05
Filed: 1994-11-10
Abstract: An apparatus and process for combining an organic fibrous material with a thermoplastic material forming a wood-imitating composite. The mixed material is extruded into a die system comprising a transition die, a stranding die and a molding die. The flow rate of the material through the die system is equalized by preforming the mixed material with the transition die to a shape approaching the end product, stranding the material with the stranding die to form individual strands, and compressing the individual strands with the molding die after it exits the stranding die. The die system may also include an adapter die positioned between the extruder and the transition die which functions to control the amount of mixed material which enters the die system. A product comprised of recyclables shredded and mixed to form a wood-imitating composite from a low-temperature extruder is also provided.
Patent NZ-299861-A (NZ)
Title: Flat drive motor for front loading washing machine with rotor located within stator so as to minimise overheating
Inventor: SKRIPPEK JOERG
IPC: H02K29/00
Filed: 1996-12-02
Abstract: The drive has the motor (9) stator (10) bonded to the rear wall (6) of the container housing (1) in place of the stiff carrier, with a central bearing bush (26) for the shaft (7) of the drum (4). The rotor (13) is at the outer end of the shaft, in a central mounting, with magnetising poles (14) distributed round its circumference. There is a minimum air gap between them and the plate packets (35) holding the energising coils (12) , facing the poles (14), at the flange (11) integrated into the inner surface of the stator (10). The packets (35) are formed of dynamo plates.
Patent NZ-326061-A (NZ)
Title: Otic microbial combinations
Inventor: GROH MICHAEL
IPC: A61P27/16
Filed: 1996-12-10
Abstract: Provided is a method of treating an otic infection comprising administering a composition containing a therapeutically active combination of silver sulfadiazine and an antimicrobial agent.  Preferably the composition is administered twice daily.
Patent NZ-330387-A (NZ)
Title: Process for preparing 2-(2-methylphenyl)-3- methoxyacrylic acid methylester by formylating 2-methylphenylacetic acid methylester
Inventor: KEIL MICHAEL
IPC: C07C69/734
Filed: 1997-02-17
Abstract: isclosed is a process for preparing 2-(2-methylphenyl)-3-methoxyacrylic acid methylester (I) by formylation of 2-methylphenylacetic acid methylester (II) in an inert solvent in the presence of a base, and subsequent methylation of the resulting enolate (III) in which M+ is an alkali metal cation.
Patent NZ-337175-A (NZ)
Title: Vector comprising first and second recombining sites in parallel or anti-parallel orientation with adjoining coding sequences and promoters
Inventor: MCVEY DUNCAN L
IPC: C12N15/34
Filed: 1996-08-27
Abstract: he vector is claimed comprising a first recombining site and a second recombining site in parallel orientation between, which are located i)	a first coding sequence which adjoins the first recombining site such that the first coding sequence is oriented to be transcribed in the direction from the first recombining site to the second recombining site proceeding through the first coding sequence and which is not operably linked to a promoter and ii)	a promoter which adjoins the second recombining site such that the promoter is oriented to direct transcription in the direction from the first recombining site to the second recombining site proceeding through the promoter. A method of effecting site specific recombination in an eukaryotic cell using the vector as described above is claimed.
Patent NZ-500012-A (NZ)
Title: A gene delivery vehicle expressing the apoptosis-inducing proteins VP2 and/or apoptin
Inventor: PIETERSEN ALEXANDRA MARIA
IPC: A61K38/00
Filed: 1998-04-15
Abstract: A host cell comprises a gene delivery vehicle, and a gene delivery vehicle that comprises an adenoviral vector that comprises a nucleic acid molecule encoding apoptin-like activity. The gene delivery vehicle is useful for the treatment of cancer.
Patent NZ-503435-A (NZ)
Title: Oxime substituted 1-(3-(heteroaryl)phenyl)-benzimidazole compounds having GABA activity
Inventor: ICHIMARU YASUYUKI
IPC: A61P25/22
Filed: 1998-10-08
Abstract: A benzimidazole compound has the formula (I) or a pharmaceutically acceptable salt thereof wherein: R11 is a 5 or 6 membered monocyclic heteroaryl group containing at least one nitrogen or an N-oxide thereof; one of R6 and R7 is H and the other is CR'=NOR"; R' is H, alkyl, alkenyl, alkynyl or phenyl; R" is alkyl, alkenyl, alkynyl or phenyl substituted with one or more hydroxy groups. A pharmaceutical composition thereof is useful for treating anxiety, sleep or memory disorders or epilepsy or other convulsive disorders.
Patent NZ-508225-A (NZ)
Title: A process for producing an iron-dextran compound
Inventor: ANDREASEN HANS BERG
IPC: A61K47/48
Filed: 1999-07-29
Abstract: A process for producing an iron-dextran compound, in which the molecular weight of a dextran is reduced by hydrolysis, and functional aldehyde terminal groups thereof are converted into alcohol groups by hydrogenation; comprises combining dextran as an aqueous solution with at least one water-soluble ferric salt. Base is then added to the resulting solution to form ferric hydroxide, and the resulting mixture is heated to transform the ferric hydroxide into ferric oxyhydroxide as an association compound with the dextran, characterized in that the hydrogenation is only partial leaving, at the most 15% by weight reducing sugar, calculated on the total amount of carbon hydrates, Before the dextran is combined with the ferric salt, and after being subjected to hydrogenation it is subjected to an oxidation. The hydrogenation and oxidation being performed to obtain dextran having substantially all aldehyde groups converted into alcohol and carboxylic groups. Also described is a pharmaceutical composition comprising the iron-dextran compound produced by the above process for the treatment of iron-deficiency.
Patent NZ-508594-A (NZ)
Title: Glycopeptide derivatives and pharmaceutical compositions containing the same
Inventor: JUDICE J KEVIN
IPC: A61K38/00
Filed: 1999-12-22
Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: -Ra-Y-Rb-(Z)x where Ra, Rb, Y, Z and x are as defined in the specification, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
Patent NZ-511995-A (NZ)
Title: A ras-farnesyltransferase inhibitor complex that is stable and water soluble and useful as an anti-tumour agent
Inventor: VARIA SAILESH A
IPC: A61K47/48
Filed: 1999-12-21
Abstract: Described is a ras-farnesyltransferase inhibitor complex formed of ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, of formula (I), wherein n is 0 or 1; R1 is selected from Cl, Br, phenyl, pyridyl or cyano; R2 is aralkyl; R3 is selected from lower alkyl, aryl or substituted aryl or heterocyclo; Z1 is selected from CO, SO2, CO2 or SO2NR5, R5 is selected from hydrogen, lower alkyl or substituted alkyl; and sulfobutylether-7- beta -cyclodextrin or 2-hydroxypropyl- beta -cyclodextrin. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor and is useful for its intravenous delivery to humans with cancer. Also provided is a method for forming the complex. The ras-farnesyltransferase inhibitors are useful as anti- tumour agents.
Patent NZ-513143-A (NZ)
Title: Color image processing method and apparatus thereof
Inventor: SHIN HYUN-DOO
IPC: G06V10/56
Filed: 2000-02-03
Abstract: A colour image processing apparatus for retrieving a colour feature descriptor for describing colour features of an image comprises: a colour vector retrieving unit (302) for receiving pixel value data of an input image and retrieving colour vectors for a predetermined colour coordinate system; a colour feature descriptor generating unit (304) for obtaining at least one class of the colour vectors by classifying the colour vectors based on a distribution of values of the colour vectors, obtaining at least one dominant colour and ratio thereof from the at least one class and generating and outputting colour feature descriptor data containing the information on the at least one dominant colour and ratio thereof and a combining unit (306) for combining pixel value data and colour feature descriptor data to output a processed image. A colour image processing apparatus for retrieving a colour feature descriptor for describing colour features of an image, comprises: a segmenting unit (300) for segmenting an input image into k regions, wherein k is an arbitrary positive integer, and sequentially outputting pixel value data corresponding to the kth region; a colour vector retrieving unit (302) for receiving pixel value data of an input image and retrieving colour vectors for a predetermined colour coordinate system and a colour feature descriptor generating unit (304) for obtaining the percentiles of dominant colours represented by the colour vectors when the colour vectors are all received and generating and outputting colour feature descriptor data containing the information on the dominant colours and the percentiles thereof. A colour vector is defined by the expression [cLi, cUi, cVi] where i is an arbitrary serial number of primary regions ranging from 1 to N and L, U and V denote coordinates of the CIE LUV colour coordinate system. The colour feature descriptor (F) is defined by the expression {{[cLi, cUi, cVi], Pi} I=1, _, N} where Pi is the percentile relating to the colour vector [cLi, cUi, cVi].
Patent NZ-513242-A (NZ)
Title: Purification of biological substances
Inventor: KOPF HENRY B
IPC: C12N7/02
Filed: 2000-02-22
Abstract: A process and apparatus for purifying target biological substances such as selected proteins, antibodies, antigens, clotting factors, glycoproteins and hormones from a source liquid, employing sequential chromatography and diafiltration steps in a cross-flow filtration system, to provide purification with advantageous yield, product purity, and cost -and time-efficiency.
Patent NZ-514729-A (NZ)
Title: Guanidine derivatives useful as IL-8 receptor antagonists
Inventor: PALOVICH MICHAEL R
IPC: A61P31/04
Filed: 2000-05-26
Abstract: A guanidine derivative has the formula (I) wherein: R is OH, SH, NHSO2Rd; Rd is NR6R7, alkyl, or optionally substituted arylalkyl, arylalkenyl, heteroaryl, heteroaryl-alkyl, heteroaryl alkenyl, heterocyclic or heterocyclic-alkyl; R1 is hydrogen, halogen, nitro, cyano, haloalkyl, alkyl, alkenyl, alkoxy, haloalkoxy, azide, (CR8R8)qS(O)tR4, hydroxy, hydroxy alkyl, aryl, arylalkyl, aryloxy, arylalkyloxy, heteroaryl, heteroarylalkyl, heterocyclic, heterocyclic-alkyl, heteroaryl alkyloxy, arylalkenyl, heteroaryl-alkenyl, heterocyclic-alkenyl, (CR8R8)qNR4R5, alkenyl-C(O)NR4R5, (CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3H, S(O)3R8, (CR8R8)qC(O)R11, alkenyl-C(O)R11, alkenyl- C(O)OR11-(CR8R8)qC(O)OR12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qNHS(O)2R17, (CR8R8)qS(O)2NR4R5, or two R1 moieties together may form O-(CH2)s-O- or a 5 to 6 membered unsaturated ring; R2 is optionally substituted alkyl or alkenyl; R3 is alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, azide, S(O)tR4, (CR8R8)qS(O)tR4, hydroxy, hydroxyalkyl, aryl, arylalkyl, arylalkenyl, aryloxy, arylalkyloxy, heteroaryl, heteroarylalkyl, heteroaryl alkenyl, heteroaryl heterocyclic, heterocyclic-alkyl, alkyloxy, heterocyclic- alkyloxy, heterocyclic-alkenyl, (CR8R8)qNR4R5, (CR8R8)qC(O)NR4R5, alkenyl-C(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3R8, (CR8R8)qC(O)R11, alkenyl-C(O)R11, alkenylC(O)OR11, (CR8R8)qOC(O)R11, (CR8R8)qC(O)OR11, (CR8R8)qNR4C(O)R11, (CR8R8)qC(NR4)NR4R5, (CR8R8)qNR4C(NR5)R11, (CR8R8)qNHS(O)2R13, (CR8R8)qS(O)2NR4R5, or two R3 moieties together may form O-(CH2)s-O- or a 5 to 6 membered optionally saturated ring, and wherein the alkyl, aryl, arylalkyl heteroaryl, heterocyclic moieties may be optionally substituted; q is 0 to 10; t is 0 to 2 and s is to 3; Y is hydrogen, halogen, nitro, cyano, halo alkyl, alkyl, alkenyl, alkoxy, haloalkoxy, azide, (CR8R8)qS(O)tR4, hydroxy, hydroxyalkyl, aryl, arylalkyl, aryloxy, arylalkyloxy, heteroaryl, heteroarylalkyl, heteroaryl alkyloxy, heterocyclic, heterocyclic-alkyl, arylalkenyl, heteroaryl-alkenyl, heterocyclic- alkenyl, (CR8R8)qNR4R5, alkenyl-C(O)NR4R5, (CR8R8)qC(O)NR4R5, S(O)3R8, S(O)3H, (CR8R8)qC(O)R11, alkenyl-C(O)R11, alkenyl-C(O)OR11, C(O)R11, (CR8R8)qC(O)R12, (CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)qNHS(O)2Rd, (CR8R8)qS(O)2NR4R5, or two Y moieties together may form O-(CH2)s-O- or a 5 to 6 membered unsaturated ring; n is 1 to 3 and m is 1 to 3 and R4 to R8, R10 to R13 and R17 are as defined in the specification. The compounds are useful for treating psoriasis, atopic dermatitis, arthritis, asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, stroke, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cardiac and renal reperfusion injury, glomerulonephritis, thrombosis, graft vs. host reaction, Alzheimer's disease, allograft rejections, malaria, restenosis, angiogenesis, atherosclerosis, osteoporosis, gingivitis and undesired hematopoietic stem cells release.