baber/WOPTO huggingface dataset:
Patent WO-2019032961-A1 (WO)
Title: Trioxacarcin-antibody conjugates and uses thereof
Inventor: MYERS ANDREW G
IPC: A61K31/35
Filed: 2018-08-10
Abstract: Provided herein are trioxacarcin-antibody drug conjugates of Formula (I): and pharmaceutically acceptable salts thereof, wherein R7 is -L-B, wherein L is a linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin- antibody drug conjugates (e.g., compounds of Formula (II), novel trioxacarcins without an antibody conjugated thereto), pharmaceutical compositions thereof, and methods of their use and treatment.
Patent WO-2019060066-A1 (WO)
Title: Systems and methods of detecting and responding to a visitor to a smart home environment
Inventor: GOULDEN JASON
IPC: G08B13/196
Filed: 2018-08-16
Abstract: A method of detecting and responding to a visitor to a smart home environment via an electronic greeting system of the smart home environment, including determining that a visitor is approaching an entryway of the smart home environment; initiating a facial recognition operation while the visitor is approaching the entryway; initiating an observation window in response to the determination that a visitor is approaching the entryway; obtaining context information from one or more sensors of the smart home environment during the observation window; and at the end of the time window, initiating a response to the detected approach of the visitor based on the context information and/or an outcome of the facial recognition operation.
Patent WO-2019040673-A1 (WO)
Title: Snap fit golf bag assembly
Inventor: MARTELL JAMES
IPC: A63B55/10
Filed: 2018-08-22
Abstract: A golf bag includes a divider top, a base, and a plurality of stays comprising a first stay, a second stay, and a main stay having a first end opposite a second end. The golf bag further comprises a top hinge coupled to the first end of the main stay. A base hinge can be coupled to the second end of the main stay, wherein the main stay can be hingedly connected to the divider top by the top hinge, and the stay can be hingedly connected to the base by the base hinge. Other embodiment of the golf bag are also described.
Patent WO-2019046343-A1 (WO)
Title: Iron-selenide-oxide sorbent composition for removing mercury (hg) vapor from a gaseous stream; methods of use and methods of manufacture
Inventor: HUANG YONGHENG
IPC: B01J20/30
Filed: 2018-08-28
Abstract: A powdered Iron-Selenide-Oxide sorbent composition, a method of using the sorbent, and a method for producing the sorbent is disclosed for removing mercury vapor from a gaseous stream. The exact ratios of Fe to Se are varied. The method for producing the sorbent comprises the steps of: preparing a base ferrous or ferric oxide (FeOx) media, conditioning the FeOx media with a slurry of ferrous selenite (FeSeO3)/ ferrous selenate (FeSeO4), reducing the FeSeO3/FeSeO4 mixture by an elemental iron (Fe0) powder to incorporate selenide into the slurry, and dewatering and oxidizing the slurry. The sorbent can be used alone (or in combination with a powdered activated carbon material or an inert powdered material) by direct injection into the Hg-containing gas stream, by coating of a filter fabric used in bag house with the sorbent, or by using the sorbent in a packed bed gas stream filtration system.
Patent WO-2019046753-A1 (WO)
Title: Pond sealing method
Inventor: HENNIS JAMES
IPC: C04B24/24
Filed: 2018-08-31
Abstract: A method of treating a pond, lake or other body of water to improve the retention of water includes treating the ground at the bed of the pond with bentonite clay, a super absorbent polymer, a polysaccharide, and a polymer flocculant. The bentonite clay can be granulated #16 Wyoming bentonite clay, the super absorbent polymer can be granulated polyacrylamide, the polysaccharide can be granulated carboxy methyl cellulose, and the polymer flocculant can be a high-performance polymer flocculant, such as 2-Propenoic Acid, polymer with 2-Promenamide, sodium salt 90-100%.
Patent WO-2019060188-A1 (WO)
Title: Catalytic cycle for production of 1,1-disubstituted alkenes
Inventor: SULLIVAN JEFFREY M
IPC: C07C69/15
Filed: 2018-09-12
Abstract: The present teachings disclose contacting an amine salt catalyst with a dicarbonyl compound having an alkylene group between the carbonyl group; adding formaldehyde, paraformaldehyde, or formalin in an amount of about 2:1 to about 3:1 moles of formaldehyde to moles of the dicarbonyl compound to form a mixture; and refluxing the mixture. The process forms a carbonyl-substituted alkene. The process may be performed in the absence of a solvent. The process may form methylene malonates, methylene dimalonates, methylene keto malonamides, methylene diketones, methylene keto esters, and the like.
Patent WO-2019079794-A1 (WO)
Title: Treatment of cardiac dysfunction
Inventor: MISSLING CHRISTOPHER U
IPC: A61K31/341
Filed: 2018-10-22
Abstract: A method for treatment of cardiac dysfunction comprising administering to a subject in need thereof a therapeutically effective amount of at least one of ANAVEX 2-73 or ANAVEX 19-144 or pharmaceutically acceptable salt thereof or combination thereof.
Patent WO-2019089617-A1 (WO)
Inventor: Charlton Ebony James
IPC: G06F3/0487
Filed: 2018-10-30
Abstract: La présente invention concerne un système d'affichage de contenu pouvant commander quel contenu est affiché et comment le contenu est affiché sur la base de paramètres de visualisation, tels qu'un niveau de zoom de carte, et des paramètres de distance physique, par exemple, une distance de géo-clôture et une distance de visibilité d'icône. Différentes combinaisons d'entrées (par exemple, un niveau de zoom et des distances physiques) fournissent un grand nombre d'affichages de contenu prédéfinis sur le dispositif client, ce qui permet à un créateur d'une icône de régler finement la manière dont le contenu est affiché ou autrement accédé.
Patent WO-2019094404-A1 (WO)
Title: Compositions et méthodes destinées à des lymphocytes t améliorés
Inventor: ZHANG YI
IPC: A61K48/00
Filed: 2018-11-07
Abstract: L'invention concerne des compositions et des méthodes destinées à la génération de lymphocytes T améliorés ayant une activité Ezh2 accrue, et leurs procédés d'utilisation dans le traitement du cancer et d'infections chroniques.
Patent WO-2019113387-A1 (WO)
Title: Voies de biosynthèse manipulées pour la production de (6e)-8-hydroxygéraniol par fermentation
Inventor: TRACEWELL CARA
IPC: C12P5/00
Filed: 2018-12-06
Abstract: La présente invention concerne la manipulation de cellules microbiennes pour la production par fermentation de (6E)-8-hydroxygéraniol et concerne de nouvelles cultures et cellules microbiennes manipulées, ainsi qu'un procédé de production de (6E)-8-hydroxygéraniol.
Patent WO-2019113570-A1 (WO)
Title: Revêtements antireflet sur guides d'ondes optiques
Inventor: PEROZ CHRISTOPHE
IPC: G02B5/18
Filed: 2018-12-10
Abstract: L'invention concerne un ensemble guide d'ondes antireflet comprenant un substrat de guide d'ondes à premier indice de réfraction, une pluralité d'éléments optiques de diffraction, disposés sur une première surface du guide d'ondes, et un revêtement antireflet, disposé sur une seconde surface du guide d'ondes. Le revêtement antireflet augmente de préférence l'absorption de la lumière à travers une surface sur laquelle il est appliqué dans le guide d'ondes, de sorte qu'au moins 97 % de la lumière soit transmise. Le revêtement antireflet se compose de quatre couches de matériau, dont les indices de réfraction diffèrent du premier indice de réfraction, et dont un indice de réfraction imaginaire est inférieur à 1 x 10-3, mais de préférence inférieur à 5 x 10-4.
Patent WO-2019139967-A1 (WO)
Title: Methods of detection and treatment of hyper transcription diseases
Inventor: BISHOP ALEXANDER
IPC: A61P35/00
Filed: 2019-01-09
Abstract: Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Ataxia Telangiectasia and Rad3 related Serine/Threonine protein kinase and an inhibitor of poly (ADP-ribose) polymerase (1). Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Checkpoint kinase (1) and an inhibitor of poly (ADP-ribose) polymerase (1). Also provided are methods for diagnosing hyper transcription diseases in a subject by analyzing a tissue sample from the subject for changes in the plurality of R-loops or the phosphorylation levels of RNA polymerase II.
Patent WO-2019147520-A1 (WO)
Title: Dynamic economizer methods and systems for improving profitability, savings, and liquidity via model training
Inventor: MADDEN BARTLEY
IPC: G06Q30/06
Filed: 2019-01-22
Abstract: A method of optimizing future profits may include receiving an order inquiry and/ or data of the user at a server device, including one or more product of interest, and training a machine learning model by analyzing labeled data. The method may include analyzing the data of the user and at least one product of interest using the trained machine learning model to generate a discounted price for the product of interest that is lower than the credit card price of the product of interest, and/or a credit limit associated with the user. The discounted price and/or credit limit may be transmitted to a user device, and an economizer selection may be received which circumvents the usage of a credit card, and a withdrawal request and/or deposit request may be initiated in response to the economizer selection.
Patent WO-2019148035-A1 (WO)
Title: Integrated desalination-power system
Inventor: WALTER JENNINGS
IPC: C02F1/00
Filed: 2019-01-25
Abstract: An exemplary desalination-power system utilizes turbines configured within a water intake conduit to the desalination processor to produce power for the desalination processor. Water intakes are configured to provide a natural flow of water to the desalination processor though hydrostatic pressure. One or more turbines coupled with the water intake conduits are driven and produce power for the system. The desalination processor incorporates Graphene filters to and may include a structured water system to increase the H302 concentration of the water prior to Graphene filters. Discharge water may be pumped back into the body of water but be separated from the intakes. A secondary power source, such as a renewable power source, may be used to produce supplemental power for the system. Power produced may be provided to a secondary outlet, such as a power grid, ail above and/or underground.
Patent WO-2019152728-A1 (WO)
Title: Methods of quantifying methylglyoxal-induced nucleic acid adducts
Inventor: RAHBAR SAMUEL
IPC: A61P35/00
Filed: 2019-01-31
Abstract: Methods of quantifying a  N 
   2   -(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and  N 
   2   -(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.
Patent WO-2019161251-A1 (WO)
Title: Cell data recorders and uses thereof
Inventor: LIU DAVID
IPC: C12N15/10
Filed: 2019-02-15
Abstract: Described herein are compositions, vectors, cells, methods, and kits that provide cell data recorder systems for recording cell states. The cell data recorder systems allow for the recording of both the presence and duration of one or more stimuli in a programmable, reproducible, and multiplexable manner. These cell data recorder systems employ a nucleic acid programmable DNA binding protein, such as a Cas9 nuclease, or a fusion protein comprising a nucleic acid programmable DNA binding domain and a nucleic acid editing domain to introduce recordable changes in the genome of a cell or in a plasmid within the cell.
Patent WO-2019177922-A1 (WO)
Title: Heterogeneous smart cart data stream processing
Inventor: KUMAR SUDEEP
IPC: G06Q30/06
Filed: 2019-03-11
Abstract: A network service or application can receive dietary goals or conditions for a user or group of users. The network can determine threshold dietary amounts that users can receive over a predetermined time period to satisfy the goals or conditions. The network can monitor user consumption over the predetermined time period by collecting data from heterogeneous data streams (e.g., data associated with different structures, data types, types of data store, sources, processing rates, etc.), processing the data, storing the data using a distributive processing framework, and exposing optimized views into the data to provide smart virtual shopping cart functionality. The network can evaluate user consumption and food items placed into a virtual shopping cart to determine whether purchasing the items satisfy the thresholds, and if not, issue warnings, provide recommendations for substitute food items, and/or take other appropriate actions.
Patent WO-2019190798-A1 (WO)
Title: Breast ultrasound scanning
Inventor: WANG SHIH-PING
IPC: A61B5/00
Filed: 2019-03-18
Abstract: A method and apparatus for acquisition of volumetric breast images for screening and/or diagnosing breast cancers using a rotary scanning template and transducer.
Patent WO-2019190898-A1 (WO)
Title: Multimodal polyethylene composition
Inventor: BORSE NITIN
IPC: C08F210/16
Filed: 2019-03-22
Abstract: A bimodal polyethylene composition, products made therefrom, methods of making and using same, and articles, including bottle caps and closures, containing same.
Patent WO-2020018154-A1 (WO)
Title: Method and system for digital staining of label-free phase images using deep learning
Inventor: OZCAN AYDOGAN
IPC: G01N21/17
Filed: 2019-03-29
Abstract: A deep learning-based digital staining method and system are disclosed that provides a label-free approach to create a virtually-stained microscopic images from quantitative phase images (QPI) of label-free samples. The methods bypass the standard histochemical staining process, saving time and cost. This method is based on deep learning, and uses a convolutional neural network trained using a generative adversarial network model to transform QPI images of an unlabeled sample into an image that is equivalent to the brightfield image of the chemically stained-version of the same sample. This label-free digital staining method eliminates cumbersome and costly histochemical staining procedures, and would significantly simplify tissue preparation in pathology and histology fields.
Patent WO-2019209551-A1 (WO)
Title: Molded articles
Inventor: LU KERAN
IPC: C08L23/08
Filed: 2019-04-12
Abstract: A molded article formed from a polymer composition, the polymer composition consisting essentially of: an ethylene homopolymer or ethylene/alpha-olefin copolymer; greater than 20 ppm of a fluoropolymer; and optionally, up to 5 wt.% of one or more of processing aids, acid neutralizers, stabilizers, phosphites, antioxidants, metal de-activators, pigments or colorants, or fillers; wherein the molded article exhibits an oxygen transmission rate [OTR, (cc*mm)/(m 2 *day*atm)] ? -3181 (cc 2 *mm)/g*m 2 *day*atm) X [Density, g/cc] + 3077, (cc*mm)/(m 2 *day*atm).
Patent WO-2019212881-A1 (WO)
Title: Methods for evaluating suitability of a biochemical filter
Inventor: MAO NATHAN
IPC: G01N33/538
Filed: 2019-04-26
Abstract: Embodiments of the present disclosure include methods and systems for detecting the presence of endotoxins in filters. For example, embodiments of the present disclosure are directed to methods and systems for improving in-process controls by detecting undesirable quantities of endotoxins in filters containing naturally-sourced materials prior to using those filters in the production of formulated drug substances.
Patent WO-2019210133-A1 (WO)
Title: Methods and systems for monitoring coupling of fifth wheels to kingpins
Inventor: GAUFIN CARL
IPC: B62D53/08
Filed: 2019-04-26
Abstract: A fifth wheel system includes a fifth wheel configured to couple to a kingpin of a towed trailer such that vibrations are generated when the fifth wheel couples to the kingpin. A sensor in operative association with the fifth wheel and configured to sense the vibrations and generates vibration data. A controller receives the vibration data and processes the vibration data to detect a presence or an absence of a predetermined vibration component that occurs when the fifth wheel properly couples to the kingpin. An indicator indicates proper coupling of the fifth wheel to the kingpin when the predetermined vibration component is present.
Patent WO-2019217165-A1 (WO)
Title: Therapeutic uses of glp1r agonists
Inventor: FREEMAN JENNIFER L R
IPC: A61K31/538
Filed: 2019-05-01
Abstract: Methods of using glucagon-like peptide 1 receptor (GLP1R) agonists are generally disclosed herein. In certain aspects, the disclosure provides methods of treating type 2 diabetes that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of treating obesity that include administering a GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of lowering glycated hemoglobin (for example, lowering HbA1c) that include administering a GLP1R agonist according to certain dosage regimens. Compositions containing GLP1R agonists and their manufacture, for example, for use as a medicament are also disclosed herein.
Patent WO-2019213636-A1 (WO)
Title: Light fixture with dynamically controllable light distribution
Inventor: DIANA FREDERIC STEPHANE
IPC: H05K1/18
Filed: 2019-05-04
Abstract: A light engine and system are disclosed in which the light engine contains a core comprising an opening extending through opposing surfaces and a flexible printed circuit board (PCB). The PCB includes a flexible body disposed on an outside of the core and having independently addressable sets of illumination sources mounted thereto, and flexible legs extending from the body and through the opening. The legs are bent such that a terminal portion of each leg is substantially parallel to the opposing surfaces of the core. Independent control of the sets of illumination sources is provided via the legs. The body is separated into segments, each on a different section of the outside and containing body contacts electrically independent of the body contacts of each other segment. Each leg is associated with a different segment, and contains leg contacts on the terminal portion in electrical contact with the associated body contacts.
Patent WO-2019222045-A1 (WO)
Title: Micro-fusion-enhanced hybrid propulsion for high-altitude aircraft and space planes
Inventor: DREXLER JEROME
IPC: B64C29/04
Filed: 2019-05-10
Abstract: A spaceplane (11) and hybrid reaction engine (31, 51, 61) employ micro-fusion enhanced propulsion in the presence of ambient cosmic rays (15) and muons (μ) in the upper atmosphere at altitudes greater than 20km. The reaction engines for the spaceplane may be of different types operable in different speed and altitude regimes, but at least one engine type incorporates a supply of deuterium-containing micro-fusion fuel that can be injected (38, 44, 63) into the fuel mix along with the primary chemical fuel or into the exhaust in the nozzle section (42, 57, 69). The energetic fusion products from particle-target and/or muon-catalyzed fusion provide supplemental thrust for the spaceplane.
Patent WO-2020076371-A1 (WO)
Inventor: GHAHREMANI AHMADREZA
IPC: A61B5/08
Filed: 2019-05-30
Abstract: A compact radar system for detecting displacement of an internal organ of a patient in a medical scanner. The system includes at least one transmitting antenna and at least one receiving antenna located in a bed arrangement that supports the patient. In particular, the receiving antenna is located a predetermined distance from a patient reference location to enable detection of electromagnetic energy reflected from a region of the internal organ undergoing asymmetric displacement. The system further includes a radar energizing system that energizes the transmitting and receiving antennas wherein the transmitting antenna irradiates a volume of the patient's body that includes the internal organ. In addition, the receiving antenna detects the reflected electromagnetic energy from the region of the internal organ undergoing asymmetric displacement to enable determination of inhalation and exhalation by the patient.
Patent WO-2019241073-A1 (WO)
Title: Increased durability linear actuator
Inventor: BUCHANAN DALE ALAN
IPC: H02K41/02
Filed: 2019-06-07
Abstract: A linear actuator includes a motor, a shaft, and a casing. The shaft has a longitudinal axis, and the shaft is moveable along the longitudinal axis by the motor. The casing supports the motor and the shaft with a tapered roller bearing positioned between at least a portion of the shaft and a portion of the casing.
Patent WO-2019245792-A1 (WO)
Title: Nouveau procédé de fabrication de nanoparticules métalliques et de matériaux monoatomiques métalliques sur divers substrats et nouvelles compositions
Inventor: LIANG XINHUA
IPC: C23C16/00
Filed: 2019-06-11
Abstract: La présente invention concerne un nouveau procédé et de nouvelles compositions comprenant des matériaux métalliques particulaires bien dispersés, notamment des nanoparticules métalliques et/ou des matériaux monoatomiques métallique, sur divers substrats, ledit procédé comprenant l'utilisation d'un dépôt de couche atomique (ALD) et l'optimisation du temps de dose du précurseur métallique et du nombre de cycles d'ALD. Des exemples de métaux donnés à titre d'illustration sont Fe, Ni, Co, Ru, Rh, Ir, Os, Pt, Pd et similaires ; et des exemples des divers substrats donnés à titre d'illustration sont des nanotubes de carbone (CNT), y compris les nanotubes de carbone à parois multiples (MWCNT), le SiO2, le TiO2, l'alumine, le CeO2, le ZnO, le ZrO2, le charbon actif, le CuO, le Fe203, le MgO, le CaO, le graphène, etc. La densité des métaux dispersés sur les substrats est significativement supérieure à la densité de métal obtenue dans des procédés précédemment rapportés. Ainsi, un élément clé qui distingue ce procédé des procédés de l'état de la technique, est que les nouvelles compositions obtenues possèdent un plus grand nombre d'atomes par surface donnée sur le substrat.
Patent WO-2020006317-A1 (WO)
Title: Tunable immune responsive biodegradable arginine-based poly(ester amide)s and methods of making and using same
Inventor: CHU CHIH-CHANG
IPC: A61L27/34
Filed: 2019-06-27
Abstract: The present disclosure provides poly(ester amide)s (PEAs) containing NO-Arg groups. The PEAs may be used to treat diseases having inflammation and/or diseases associated with inflammation. The PEAs may be used to treat wounds, such as, for example, wounds associated with obesity and/or diabetes. The PEAs may be incorporated into various articles such as medical devices, such as, for example, bandages and other wound care articles/devices.
Patent WO-2020014245-A1 (WO)
Inventor: BESSETTE SHANNYN
IPC: A01N1/02
Filed: 2019-07-09
Abstract: L'invention concerne des procédés et des compositions de milieu pour la cryopréservation de cellules NK-92 ®.
Patent WO-2020014605-A1 (WO)
Title: Inhibitors of histone deacetylase
Inventor: FULLER NATHAN
IPC: C07D401/12
Filed: 2019-07-12
Abstract: Provided herein are compounds of the Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone deacetylases (HDAC).