baber/WOPTO huggingface dataset:
Patent SG-11201810423X-A (SG)
Title: Pd-1 / pd-l1 inhibitors for cancer treatment
Inventor: NUYTEN DIMITRY
IPC: C07K16/28
Filed: 2017-05-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 1111111111111111111111111111111111111111111111111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/202744 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61P 35/00 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — with sequence listing part of description (Rule 5.2(a)) PCT/EP2017/062213 (22) International Filing Date: 22 May 2017 (22.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/341,921 26 May 2016 (26.05.2016) US 62/423,358 17 November 2016 (17.11.2016) US 62/471,459 15 March 2017 (15.03.2017) US (71) Applicants: MERCK PATENT GMBH [DE/DE]; Frank- furter Strasse 250, 64293 Darmstadt (DE). PFIZER INC. [US/US]; 235 East 42nd Street, NEW YORK, NY 10017 (US). (72) Inventors: NUYTEN, Dimitry; 101 Lombard Street, Apt _ 306W, SAN FRANCISCO, CA 94111 (US). MOROZOV, Alexei; c/o Pfizer Inc. 235 East 42nd Street, NEW YORK, NY 10017 (US). WOOLFSON, Adrian; 275 Conover = Street, Apt 4R, BROOKLYN, NEW YORK 11231 (US). = THALL, Aron; 6706 Torenia Trail, SAN DIEGO, CA — — 92130, New York (US). CHIN, Kevin; 4 Huckleberry = Lane, SUDBURY, MA 01776 (US). BRAR, Satjit; 9976 = Fox Meadow Road, SAN DIEGO, CA 92127 (US). Designated States (unless otherwise indicated, for every = (81) _ = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = — KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = = _ _ PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = — Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = _ 1-1 71' 71' IN ei © ei N (54) Title: PD-1 / PD-L1 INHIBITORS FOR CANCER TREATMENT 1-1 0 (57) : The invention relates to methods of treating cancer in a subject, comprising administering to the subject a therapeutically ei effective amount of an inhibitor of the interaction between the PD-1 receptor and its ligand PD-L1.
Patent SG-11201908303R-A (SG)
Title: Tungsten silicide target and method of manufacturing same
Inventor: ODA KUNIHIRO
IPC: C23C14/06
Filed: 2018-01-22
Abstract: A tungsten silicide target capable of suppressing the occurrence of particles during sputtering is provided by a method different from conventional methods. The tungsten silicide target includes not more than 5 low-density semi-sintered portions having a size of 50  m or more per 80000 mm2 on the sputtering surface.
Patent IS-2598-B (IS)
Inventor: REYNOLDS RACHEL HEULWEN
IPC: A61P21/00
Filed: 2004-01-19
Abstract: The invention relates to a compound of formula (1): in which R<SUP>1 </SUP>and R<SUP>2 </SUP>each independently represent a C<SUB>1-6</SUB>alkyl, C<SUB>3-6</SUB>alkenyl, C<SUB>3-6</SUB>cycloalkylC<SUB>1-3</SUB>alkyl or C<SUB>3-6</SUB>cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R<SUP>3 </SUP>is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R<SUP>4</SUP>)(R<SUP>5</SUP>)- in which R<SUP>4 </SUP>is a hydrogen atom or C<SUB>1-4</SUB>alkyl and R<SUP>5 </SUP>is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.
Patent YU-45400-B (YU)
Title: Process for obtaining alkyl-sulphonyl chloride and arylalkylsulphonyl chloride
Inventor: BARBERO M
IPC: C07C67/00
Filed: 1987-01-22
Abstract: Process for preparing alkyl-sulphonyl chlorides and arylalkyl-sulphonyl chlorides of formula RSO<sub>2</sub>Cl (R being alkyl or arylalkyl), starting from S,S-dialkyl or diarylalkyl dithiocarbonates RS-CO-SR, consisting in reacting the starting compound with gaseous chlorine in the presence of water, at 0° - + 10°C.
Patent ZA-9958-B (ZA)
Title: Abrasive grinding tools with hydrated and non halogenated inorganic grinding aids.
Inventor: MEYER GERALD W
IPC: B24D11/00
Filed: 1999-01-05
Abstract: A bonded-organic tool includes a matrix of an organic bond, abrasive grains dispersed in the organic bond and a grinding aid in the form of hydrated filler, wherein the hydrated filler is selected from the group consisting of aluminum trihydrate, calcium hydroxide, magnesium hydroxide, hydrated sodium silicate, alkali metal hydrates, nesquehonite, basic magnesium carbonate, magnesium carbonate subhydrate and zinc borate. The hydrated filler endothermically releases water.
Patent AT-394373-B (AT)
Title: Refrigerant
IPC: C09K5/04
Filed: 1989-03-21
Granted: 1992-03-25
Abstract: A refrigerant for thermodynamic circuit processes of a refrigeration machine, heat pump, air-conditioning unit or the like consists, with the aim of achieving economic operation with minimal environmental hazard, of a nitrogen-oxygen compound of the general formula NOX where X = F, Cl, Br, I or N2O4 or N2O3.
Patent HU-207654-B (HU)
Title: Trowable device particularly for external fixing the fractures of small tubular bones
Inventor: BAGITS TIBOR
IPC: A61B17/64
Filed: 1987-01-23
Abstract: Disposable fixing means serving especially for external fixation of fractured small tubular bones (8) consist of fixing rods (1) made of a soft metal, preferably of aluminium, which can be bent to the optional shape, containing the series of bores (2) with axes parallel to each other arranged equally spaced from each other. Standarized pins (4), Kirschner-wires known in itselves can be introduced in said bores (2). In course of the process for positioning the fixing means according to the invention fixing rods (1) are cut to size according to necessity with pliers known in itselves and modified for this purpose. Thereafter the fixing rod (1) is adapted by bending to the shape of the injured resp. fractured part of the body and the pins (4) having been introduced earlier into the bones (8) are led through the bores (2) of the fixing rod(s) (1) or the pins (4) are introduced into the bone (8) through the bores (2) of the fixing rods(s) (1). Now the fixing rods (1) are pressed onto the pins (4) from both sides in the environment of the bores (2) receiving the spikes by means of sealing pliers known in itselves and modified for this purpose, thus establishing a difficultly releasable bond between pins (4) and fixing rods (1). At last, according to necessities, final positioning is performed by means of bending-modelling pliers formed for this purpose.
Patent HU-185796-B (HU)
Inventor: LAJOS TAMAS
IPC: B60S1/54
Filed: 1981-04-03
Abstract: A találmány tárgya kettős elosztócsatorna áramló közeg egyenletes elosztására főleg autóbuszok szélvédő fü tő-rendszeréhez, amelynek beáramlónyílása, csatornája, kiáramlónyílása(i) vannak. A találmány lényege az, hogy a csatornát egy fojtóelem primer csatornára és szekunder csatornára osztja. A fojtóelem szabályozható nagyságú nyílásokkal van ellátva. A fűtött felület, illetve a szélvédőüveg függőleges áramlásirányú méretének és a rés méretének hányadosa 100-nál kisebb. A szekunder csatorna kilépő nyílásában terelőlapátok vannak elhelyezve.  ^5 6a 2. ábra
Patent HU-194052-B (HU)
Title: Cosmetic composition against verrucae
Inventor: SZATLOCZKY ERNOE
Filed: 1985-03-12
Abstract: Cosmetic prepns. for the removal of warts contain 0.01-40.0 wt.% concn. ethyl-alcoholic extract of greater celandine (Chelidonium majus), 0.01-6.0 wt.% butyl-hydroxy-toluene, 0.01-6.0 wt.% 3,3-diphenyl-1-methyl -phenylamine-lactate and/or 0.01-3.0 wt.% lithium-chloride, made up with solvent, pref. 96 wt.% alcohol to 100 wt.%.
Patent ME-01234-B (ME)
Title: Melanocortin receptor binding mimetibodies, compositions, methods and uses
Inventor: PEETERS JOZEF
IPC: C12N15/86
Filed: 2005-10-25
Abstract: Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
Patent ME-01901-B (ME)
Title: Combination of HMG-CoA reductase inhibitors with phosphodiesterase 4 inhibitors for the treatment of inflammatory pulmonary diseases
Inventor: WOLLIN STEFAN-LUTZ
IPC: A61P11/00
Filed: 2007-07-03
Abstract: The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the preventive and curative treatment of an inflammatory pulmonary disease.
Patent YU-46666-B (YU)
Title: Zaštitni uredjaj za motore koji reaguje na struju i na temperaturu
Inventor: DE FILIPPIS P
IPC: H02H3/08
Filed: 1986-02-21
Abstract: ZAŠTITNI UREDJAJ ZA MOTORE KOJI REAGUJE NA STRUJU I NA TEMPERATURU, i koji obuhvata osnovu 38, kontaktnu polužicu 62 postavljenu na osnovi 38 normalno u prvom položaju u kome se spreče sa prvim kontaktom 56, i metalni termostat 60 postavljen na osnovi 38, naznačen time, što metalni termostat (60) obuhvata jedan čašasti termostatski metalni element (60.2) koji se trzajem pomera iz početnog čašastog oblika u obrnuti čašasti oblik, pri čemu je taj element (60.2) postavljen na osnovu (38) u svom početnom čašastom obliku, odvojeno od oslonaca i dejstva spoljnih sila, i van motorskog kola, te pri promeni oblika isključuje kontaktnu polužicu (62), kao i poseban elektrootporni grejač (58) postavljen na mesto toplotnog spoja sa elementom (60.2) termostata (60), tako da element (60.2) ostaje u početnom čašastom obliku pri napajanju grejača (58) normalnim strujama, i prelazi u prevrnuti čašasti oblik pri napajanju grejača (58) strujama bilo za brzo, bilo za zadržano isključivanje pri pojavi neispravnosti motora (18). Prijaa sadrži još 22 zavisna zahteva.
Patent ZA-93376-B (ZA)
Title: Carbamate derivatives
Inventor: TRIST DAVID
IPC: A61K31/55
Filed: 1993-01-20
Abstract: PCT No. PCT/EP93/00099 Sec. 371 Date Jul. 20, 1994 Sec. 102(e) Date Jul. 20, 1994 PCT Filed Jan. 15, 1993 PCT Pub. No. WO93/14075 PCT Pub. Date Jul. 22, 1993.The present invention relates to compound of formula (I) which are antagonists of gastrin and CCK-B receptors. The compounds of formula (I) are carbamate derivatives.    <IMAGE>  (I)
Patent AT-399323-B (AT)
Inventor: LEITL FLORIAN DIPL ING
IPC: B65D90/501
Filed: 1991-06-27
Granted: 1995-04-25
Abstract: In a tank, an inside wall (1) is surrounded with spacing (2) by an outside wall (3) forming a leakage monitoring space (4), the latter being formed by a fabric. To reduce the manufacturing costs and the weight of the tank and to save material, the leakage monitoring space (4) is formed by a resin-impregnated, cured spacer fabric (5) made of reinforcing fibres, whose one layer of fabric (6) is firmly bonded to the inside wall (1) and whose other layer of fabric (7) is firmly bonded to the outside wall (3) and whose webs (8) joining the two layers (6, 7) of the spacer fabric are directed approximately perpendicular to the inside and outside walls (1, 3), forming a hollow space (4) (Figure 2). <IMAGE>
Patent AT-403294-B (AT)
IPC: C21B11/00
Filed: 1994-10-10
Granted: 1997-12-29
Abstract: Metal oxide-containing waste material is dried and preheated before being fed into a reactor (3) where it is melted and oxidised to produce a slag and a metal bath. The slag is then subjected to a two stage redn. pressure as it flows into an iron bath reactor (4) and then an iron bath calcinator (10). In the reactor, scrap or CO/CO2 is fed in to reduce mainly non-ferrous metals which form a bath which is subjected to segregation melting technique. A raw bronze melt is removed from the bottom of the vessel and recycled to the first reactor. In the second redn. stage, CaCO3, CaO and C and optionally O2 is fed into the vessel to reduce the FeO in the slag ad produce a pig iron melt.
Patent AT-400335-B (AT)
Title: System and device for the knotting of two-dimensional and three-dimensional nets
IPC: D04G1/00
Filed: 1993-10-04
Granted: 1995-12-27
Abstract: Method and device for the manual knotting of textile nets. The rings wound by means of the device are knotted together by hand to form nets. All geometric polygonal meshes from triangular to hexagonal can be made into nets. The essence of this system is that, in order to form meshes, individual flexible rings of appropriate size are knotted together to form two-dimensional or three-dimensional nets. Additional colour effects are achieved by changing the colour of the individual rings.
Patent AT-390808-B (AT)
Inventor: GMOSER JOHANN
IPC: C08G18/24
Filed: 1986-09-19
Granted: 1990-07-10
Abstract: Cationic paint binders, particularly binders of the type used in cathodic electrodeposition coatings which crosslink through transesterification, transamidation, transurethanization, or through the reaction of chain end double bonds catalyzed with a condensation product of a dialkyltinoxide and a compound carrying at least one hydroxyl group are described. The hydroxyl compounds are the aliphatic alcohols, phenols, alkanolamines, or the reaction products of primary amines with monoepoxy compounds. The catalysts of the invention provide very good stability and good compatibility in aqueous cationic paint materials.
Patent AT-384560-B (AT)
IPC: B05B7/08
Filed: 1981-12-17
Granted: 1987-12-10
Abstract: The invention relates to a process and a device for transferring a liquid from a stationary feeding component onto a working part which is rotationally driven, for example a spraying-bell, by generating a thin sheet of liquid in the shape of a conical shell, which is stable over a distance of travel which can be defined, it being possible to define the apex angle of this shell in terms of the functional parameters of the liquid, so that it is possible to select different impact positions of the thin sheet of liquid on the transfer portion of the spraying-bell, depending on the particular liquid in question.
Patent AT-402015-B (AT)
Title: Appliance for delivering a breathing gas
Inventor: ALOY ALEXANDER DR
IPC: A61M16/00
Filed: 1995-05-02
Granted: 1997-01-27
Abstract: The appliance for delivering a breathing gas has a T-connector 2, to whose T-bar 1 is connected a transverse flow of breathing gas. A plurality of tubes 6, 7, 8, 9 with clearance cross section smaller than the clearance cross section of the tubular part 3 of the T-connector 2 abutting transversely onto the T-bar 1 are arranged transverse to the bar 1 of the T-connector 2, which tubes extend in the direction of the tubular part 3 of the T-connector 2 extending transverse to the T-bar 1.
Patent AT-409408-B (AT)
Inventor: LEHMANN UWE DR
IPC: F16C33/08
Filed: 1997-07-11
Granted: 2002-08-26
Abstract: A bearing shell with at least one retaining cam which, when looking down on the partial surface of the bearing shell, has a rectangular external contour line and an indentation on the inside, the indentation being at its largest around the center (M) of the cam. The indentation, when looking down on the partial surface, has a curved contour line. The cam is made by being either hammered or pressed using a rounded blade.
Patent CH-636241-B (CH)
Inventor: LAESSER CLAUDE
IPC: G04C3/00
Filed: 1980-12-12
Abstract: To simplify the construction of a watch comprising an analog display and an electro-optical display cell 12, the analog display is provided by two transparent discs 8a and 10a carrying minute and hour markers 8 and 10 and located in front of the cell 12. The discs are driven at their peripheries by means of a stepping motor 40. This construction permits the use of a display cell 12 of large size, which does not have hand spindles passing through it. The display cell 12 is visible through apertures in a dial 14. The watch is powered by a cell 64. There may be two separate motors for the minutes and hours discs 8a, 10a. The hand discs may show local time when the electro-optical display shows the time at a different location (Rome in Fig. 1). <IMAGE>
Patent DK-155980-B (DK)
Inventor: AKESSON YNGVE REINHOLD
IPC: B02C18/26
Filed: 1983-04-18
Abstract: A process and machine for disintegrating materials wherein the material is delivered to a disintegrating element which receives a reciprocating movement whose path is substantially parallel to the surface to be comminuted wherein the disintegrating element comprises at least one rotary cutter whose axis of rotation is substantially parallel to the surface to be comminuted with a blade having a cutting edge substantially parallel to and directed transversely to the axis of rotation whereby comminution takes place on simultaneous reciprocation of the disintegrating element and rotation of the cutter.
Patent DK-164645-B (DK)
Inventor: FREI JOSEF
IPC: B03B9/06
Filed: 1987-04-03
Abstract: A process for working up household, industrial and other similar waste for the recovery of a fibrous and/or granulated material, in which the waste material is subjected to preliminary comminution, magnetic separation, classification, drying and fractionation, wherein the light fraction resulting from the classification carried out after the magnetic separation is subjected to secondary comminution by cutting, and the heavy fraction to a predominantly granulating secondary comminution and thereafter both comminution products are recombined, dried and fractionated into fibrous matter and granulated material, is to be simplified, and in particular the costs reduced. This is achieved in that before the secondary cutting comminution appliance at least one part stream or the whole stream of the light fraction is diverted and fed directly and/or after comminution in a further comminution unit to further utlization. A device for carrying out the method is also proposed.
Patent DK-161679-B (DK)
Inventor: STEFFENS MICHAEL
IPC: B02C18/20
Filed: 1988-09-23
Abstract: In order to be able to position the cutter blades (A, B, C) of a cutter head so that they are radially adjustable in a simple manner in the smallest possible axial space, toothing, (10) is formed in an elongated hole (7) in the area of the blade root (6) at its parallel opposite internal longitudinal edges, whereby toothing (11) at parallel opposite external longitudinal edges of a shaft mounting plate (8) engages with this toothing (10), the shaft mounting plate having a central opening (9), the shape of which corresponds to the cross section of a driven shaft (9'). In this arrangement the thickness of the shaft mounting plate (8) is not greater than the depth of the elongated hole (7), although the length of the shaft mounting plate (8) is smaller than the longitudinal extension of the elongated hole (7).
Patent FI-67206-B (FI)
Inventor: MEYER NICOLAS
IPC: C08L61/06
Filed: 1979-06-18
Granted: 1984-10-31
Abstract: Concentrated boric anhydride solutions containing more than 5% of boric anhydride in an organic solvent selected from mono or polyalcohols, trialkylborate and/or dialkylacetal when the solvent also contains an acid selected from sulfuric acid and/or aromatic acids. These solutions are used as hardeners of formo-phenolic resols, more particularly for the manufacture of laminates comprising glass fibers and formo-phenolic resols.
Patent FI-77742-B (FI)
Inventor: STREICH GEORG
IPC: H01H1/20
Filed: 1982-07-30
Granted: 1988-12-30
Abstract: A contact arrangement for electric switchgear is disclosed. The contact arrangement comprises a bifurcated offset contact bridge having two contact bridge parts, each of which is inserted into an opening in an actuating contact bridge carrier. Each contact bridge part rests on a first supporting surface of the opening. A spring retainer rests against the contact bridge and a compression spring is mounted between a second surface of the opening and the spring retainer. The spring retainer is guided in the contact bridge carrier against movement transverse to the direction of motion of the carrier. Each end of each contact bridge part is provided with a semicircular contact pad which, when the contact bridge parts are placed adjacent each other, form a bifurcated circular contact pad which engages with corresponding stationary contacts. Each part of the bifurcated contact bridge is provided with a recess on both sides in the area of the offset in order to maintain both contact bridge parts in close proximity with each other and to ensure proper contact engagement.
Patent FI-82450-B (FI)
Inventor: COKER GEOFFREY GEORGE
IPC: C07D213/56
Filed: 1983-02-03
Granted: 1990-11-30
Abstract: Compounds of the formula (I): <CHEM> or salts, esters or amides thereof; wherein R1 is a C1-7 bivalent aliphatic hydrocarbon group or a single bond; R2 and R3 are the same or different and are each hydrogen, C1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R4 is hydrogen, halogen, hydroxy, cyano, C1-4 acyloxy, C1-4 alkoxy or C1-4  alkyl optionally substituted by one to three halogen atoms, X is -N= or -CH=; and A and B each represents hydrogen atoms or -CA-CB= represents -C=C- are useful in the symptomatic treatment of allergic conditions. Processes for preparing the compounds, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in the symptomatic treatment of allergic conditions are also described.
Patent FI-73891-B (FI)
Inventor: CHRISTOPHE THEOPHILE
IPC: B01D35/12
Filed: 1984-08-07
Granted: 1987-08-31
Abstract: The present invention related to a filter consisting of a stack 4 of elements 5 comprising one cylindrical side and each element consisting of several isolated sections 23-24 and provided with orifices 35 for communication of its sections with the circumferences of the element and with a rotary distribution valve 37 mounted to rotate coaxially with the cylindrical side and comprising a chamber 22a for the isolation of a first section 23 from any element of the other sections, communicating with this first section through a port of the distribution valve. The form of the port 22a and the layout of the orifices 35 are such that the first sections 23 of only one part of the elements are in communication with the chamber 22a. One application is the manufacture of a filter of small size and high efficiency.
Patent FI-83284-B (FI)
Inventor: BERNAT FONTLLADOSA ENRIQUE
IPC: A47F7/00
Filed: 1985-03-18
Granted: 1991-03-15
Abstract: A display container (2) for articles with stems such as lollipops comprises a generally conical lid for a drum-like container (1), the conical wall being provided with integrally formed recesses each having a cylindrical entry portion (6), a frusto-conical portion (7) and an inner cylindrical portion (8) to grip the stem, the recesses holding the stems parallel to the axis of the device for reception thereon of a cover (11).