baber/WOPTO huggingface dataset:
Patent DE-69425427-T2 (DE)
Inventor: GIZURARSON SVEINBJOERN
IPC: A61K9/00
Filed: 1994-02-14
Granted: 2001-02-08
Abstract: PCT No. PCT/DK94/00062 Sec. 371 Date Oct. 6, 1995 Sec. 102(e) Date Oct. 6, 1995 PCT Filed Feb. 14, 1994 PCT Pub. No. WO94/17827 PCT Pub. Date Aug. 18, 1994A novel type of formulation for the topical administration of antigens and/or vaccines to mammals via mucosal membranes comprising one or more adjuvants/vehicles selected from (a) polyoxyethylene sorbitan monoesters, (b) polyoxyethylene castor oil, (c) caprylic/capric acid glycerides and (d) gangliosides in an amount of 0.01 to 15% (v/v) calculated on the total volume of the preparation. This formulation enhances the immunological response n a mammal following mucosal administration, e.g. nasal, oral, rectal or vaginal application.
Patent DE-69431130-T2 (DE)
Inventor: BURRELL ROBERT EDWARD
IPC: C23C14/00
Filed: 1994-11-01
Granted: 2003-03-13
Abstract: Anti-microbial coatings and powders and method of forming same on medical devices are provides. The coatings are preferably formed by depositing an anti-microbial biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by vapour deposition or altered by mechanical working to produce atomic disorder are also provided. The anti-microbial effect of the coatings or powders may be further activated or enhanced by irradiating with a low linear energy transfer form of radiation such as gamma radiation. Novel anti-microbial silver materials are defined, characterized by having a positive rest potential, a Trec/Tm less than 0.33, and a grain size less than 200 nm. Anti-microbial fine grain or nanocrystalline materials are provided, together with methods of preparation, wherein the anti-microbial metal if deposited in a matrix with atoms or molecules of a different material such as other biocompatible metals (ex. Ta), trapped or absorbed oxygen, or compounds of anti-microbial metals or biocompatible metals (ex. Ag0 or TaO). The invention also extends to a method of producing an anti-microbial effect with silver materials that form complex silver ions other than Ag<+>, Ag<2+> and Ag<3+>.
Patent DE-69507087-T2 (DE)
Inventor: BRULE FRANCOIS
IPC: A47L9/14
Filed: 1995-07-24
Granted: 1999-07-08
Abstract: The disposable dust bag (1) has a rigid plate (2) to fix the bag to a removable part (6a) of the body of the vacuum cleaner. The rigid plate (2) has a suction opening (3) that couples to a suction hose and a positioning opening (4) that co-operates with a positioning stud (5) mounted on the removable part (6a). The rigid plate fits over the end of the positioning stud, which has clips at the end to hold the plate once it is pushed into position. The plate can be released from the positioning stud to remove the bag by compressing the clips at the end of the stud. The removable part that carries the stud is supported by brackets (6) inside the vacuum cleaner when it is inserted in the cleaner body. <IMAGE>
Patent DE-69510818-T2 (DE)
Inventor: BASSTEIN AUGUSTINUS
IPC: B24B3/12
Filed: 1995-12-07
Granted: 1999-11-25
Abstract: A hob cutter (4) for machining face or crown gears comprises a disc-like cutter body having an axis of rotation (6) and a number of hob teeth groups (1, 2, 3, ...) which are uniformly distributed over the circumference and which are each bounded at the front by a cutting face (S) and at the circumferential side by a clearance face (V). The cutting face and the clearance face of each hob teeth group intersect one another in a cutting edge (9) which determines the shape of the face gear to be machined. The clearance face of each hob teeth group is made up of a number of generatrices (L, m) which are each situated in a machining plane which is determined by a line which intersects or crosses the axis of rotation (6) perpendicularly and intersects the generatrix at the position of the cutting edge. The extensions of the generatrices (L, m) determining the clearance face run at a minium spacing over the outside of the downstream hob teeth group.
Patent DE-69521529-T2 (DE)
Inventor: KATO SHIRO
IPC: C07D209/24
Filed: 1995-11-27
Granted: 2001-10-11
Abstract: An indole derivative of the formula: <CHEM> wherein R1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy , lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower alkylaminosulfonyl, etc., R2 is hydrogen, halogen, lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, etc., R3 is hydrogen or lower alkyl, R4 is halogen or trifluoromethyl, R5 is lower alkyl, or a salt thereof, these compounds being potent  beta 3-adrenergic receptor-stimulating agent with excellent adrenoceptor selectivity, and being useful in the prophylaxis or treatment of obesity or diabetes mellitus.
Patent DE-69528282-T2 (DE)
Inventor: DE KEIJZER EUGENE
IPC: C09K21/14
Filed: 1995-11-23
Granted: 2003-05-08
Abstract: A process for the preparation of a melamine condensation product comprising the step of heating a starting material comprising melamine or a melamine salt in the presence of: (i) at least one organic acid, (ii) at least one ammonia or melamine salt of the organic acid, or (iii) a mixture of (i) and (ii), under reaction conditions effective for the formation of the melamine condensation product. The melamine condensation product with a residual condensation agent content of less than 1 wt. % is useful in a moldable polymer composition possessing flame-retardant properties.
Patent DE-69530192-T2 (DE)
Inventor: CHU K
IPC: A61K31/70
Filed: 1995-01-30
Granted: 2004-01-08
Abstract: A method for the treatment of a host, and in particular, a human, infected with HBV or EBV is provided that includes administering an HBV- or EBV- treatment amount of an L-nucleoside of formula (I) <CHEM> wherein R is a purine or pyrimidine base. In one preferred embodiment, the active compound is 2'-fluoro-5-methyl- beta -L-arabinofuranosyluridine (also referred to as L-FMAU) This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-ethyluracil, N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodocytosine), and N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodouracil. <IMAGE>
Patent DE-69530683-T2 (DE)
Inventor: BALDWIN J
IPC: C07D401/12
Filed: 1995-03-10
Granted: 2004-03-25
Abstract: Combinatorial libraries are disclosed which are represented by Formula I:(T'-L)q-+E,crc S+EE -C(O)-L'-II'Iwherein: +E,crc S+EE  is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. Compounds which contain aryl sulfonamides, N-acyl derivatives, and N-substituted pyrrolidines and piperidines of the formula:Y-A-CO-R1are inhibitors of serine proteases and carbonic anhydrase isozymes. They are useful in the treatment of hyper-coagulation disease and ocular diseases such as glaucoma.
Patent DE-69533552-T2 (DE)
Inventor: LEE ANN L
IPC: A61K35/74
Filed: 1995-07-11
Granted: 2005-09-22
Abstract: A process is disclosed for the large scale isolation and purification of plasmid DNA from large scale microbial fermentations. All three forms of plasmid DNA; supercoil (form I), nicked or relaxed circle (form II), and linearized (form III), are individually isolatable using the disclosed process. Highly purified DNA suitable for inclusion in a pharmaceutical composition is provided by the disclosed process.
Patent DE-69603065-T2 (DE)
Inventor: MOLO NICHOLAS J
IPC: A47J43/25
Filed: 1996-12-04
Granted: 1999-10-21
Abstract: A food grater (10) including a grater blade (12) removably mounted to the forward face of an upwardly and rearwardly inclined housing (14) positioned for the reception of the grated foodstuff. The housing has a handle (16) pivotally secured to the rear thereof and movable between an open rearwardly and downwardly inclined position bracing the housing, and a forward folded position partially nested within the rear portion of the housing.
Patent DE-69607324-T2 (DE)
Inventor: LEWIS LUNDY
IPC: H04L12/26
Filed: 1996-01-24
Granted: 2000-08-24
Abstract: Apparatus and method for learning current network behavior and predicting future behavior which utilizes a state transition graph. The graph includes nodes which represent network states, and arcs which represent trends in observable network parameters that result in a transition from a current state to another state. For example, a watch service may be instituted on multiple ports of a router, and the observed network traffic on the ports over time may be transformed into a state transition graph that represents network behavior. The network states may be labeled such as "good", or "bad", etc., according to a predetermined performance criteria. Once a state transition graph is constructed, the system may then monitor the current state and current trends of the network parameters in order to predict and display future network states. The system may include an automatic warning signal for alerting a user that the network is headed in the direction of a problematic state. The prediction of future network behavior may be made from the state transition graph, the current state of the network, and the current network trends.
Patent DE-69609723-T2 (DE)
Inventor: BOMBARDELLI EZIO
IPC: A61K31/335
Filed: 1996-05-08
Granted: 2000-12-14
Abstract: PCT No. PCT/EP96/01919 Sec. 371 Date Aug. 5, 1997 Sec. 102(e) Date Aug. 5, 1997 PCT Filed May 5, 1996 PCT Pub. No. WO96/36622 PCT Pub. Date Nov. 21, 1996The present invention relates to novel 10-deacetyl-14 beta -hydroxybaccatine III derivatives. The novel derivatives, having cytotoxic and antitumour activity, are prepared from this synton after functionalization of the hydroxyls at 1-, 14- as thiocarbonate, iminocarbonate and sulfite and possible oxidation of the hydroxyl at C10. These derivatives are subjected to a subsequent esterification at position 13- with a variously substituted isoserine chain. The products of the invention can be administered by the injective or oral route, when suitably formulated.
Patent DE-69617018-T2 (DE)
Inventor: O'COIN J
IPC: B60C7/10
Filed: 1996-07-17
Granted: 2002-07-11
Abstract: Tire has a casing defining a hollow interior, a fill disposed in the interior of the casing, and the fill including at least one layer having an initial diameter substantially the same as the initial diameter of the casing. The fill layer includes an expansion joint. When the casing expands the expansion joint expands and causes the first layer to substantially continuously contact the casing.
Patent DE-69621379-T2 (DE)
Inventor: BULUSCHEK BRUNO
IPC: B29C48/06
Filed: 1996-06-19
Granted: 2003-02-13
Abstract: Sealing device to assume the sealed junction between two channels feeding plastic at high temp. and pressure in plastic prodn. machines, e.g., extrusion heads (claimed) consists of a part (2) defining a channel (3) and a second piece (9) defining a second channel inserted into the first channel (3). The second piece has at one end an annular lip greater than its cylindrical outer surface and joined to the end by a thin annular area. The lip has an outer surface that is forced against the inner surface of the first channel (2) under a pre-stress due to the dimensional tolerances of the outside of the lip and the inside of the channel (2).
Patent DE-69630877-T2 (DE)
Inventor: SWAIN A
IPC: A61K47/48
Filed: 1996-03-27
Granted: 2004-11-11
Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
Patent DE-69637507-T2 (DE)
Inventor: BOTTERO FRANCO
IPC: B28D1/00
Filed: 1996-10-08
Granted: 2009-05-28
Abstract: To obtain a modular paving block having rough surfaces, a concrete block (10-13) is first provided. Then, the block (10-13) is split in such manner to obtain a modular paving block element (20) having a quadrilateral split rough surface (21). The starting block may be elongate (10), or slab-like (11), or a conventional self-locking concrete block (12,13). The modular paving block elements (20) are laid with their split rough surface (21) facing upwards so as to form a paving. <IMAGE>
Patent DE-69722257-T2 (DE)
Inventor: CHAWLA PAUL
IPC: A61M15/00
Filed: 1997-12-17
Granted: 2004-03-25
Abstract: A system for the administration of a powdered medicament by inhalation comprises a container (21) containing a unit dose of medicament in powder form, and a device (10) having a chamber (16) adapted to receive the container (21). The device (10) has air inlets (19, 20) by which air may be drawn into the chamber (16) and a mouthpiece (14) by which air and entrained medicament may be drawn out of the chamber (16). The chamber (16) is substantially circular or annular in form and, in use, the container (21) follows an orbital path within the chamber (16), medicament being dispensed from the container (21) through at least one opening in the container (21). Also described are novel forms of packaging for powdered medicaments which are particularly suitable for use in the system.
Patent DE-69726426-T2 (DE)
Inventor: PLOEGH L
IPC: A61K38/00
Filed: 1997-04-22
Granted: 2004-09-16
Abstract: Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.
Patent DE-69731610-T2 (DE)
Inventor: TURLEY EVA ANNE
IPC: A61K31/715
Filed: 1997-01-08
Granted: 2005-12-01
Abstract: This invention relates to the oral administration of forms of hyaluronic acid (for example hyaluronan (hyaluronic acid) and pharmaceutically acceptable salts thereof such as sodium hyaluronate), and orally administrable dosage forms containing forms of hyalruonic acid, for the prevention and/or treatment of diseases and/or conditions such as the prevention of restenosis and the treatment of an infarct (heart attack) or a stroke. The oral administration and the orally administered dosage forms may also include therapeutic agents and/or medicines which may be administered orally for the treatment and/or prevention of the diseases and/or conditions with the forms of hyaluronic acid (hyaluronan) previously described.
Patent DE-69736720-T2 (DE)
Inventor: LEMKE TIMOTHY A
IPC: H01R12/71
Filed: 1997-10-10
Granted: 2007-09-13
Abstract: Electrical connectors capable of being mounted on circuit substrates by BGA techniques are disclosed. Also disclosed is a method for manufacturing such connectors. There is at least one recess (20,22,24,26,28) on the exterior side of the connector elements. A conductive contact (16) extends from adjacent the interior side of the into the recess on the exterior side of the housing. A controlled volume of solder paste is introduced into the recess. A fusible conductive element, in the form of solder balls (82,100) is positioned in the recess. The connector is subjected to a reflow process to fuse the solder ball (82,100) to the portion of the contact extending into said recess. Contacts (66) are secured in the insulative housing of the connector by deformable sections that minimize stress imposed on the housing, thereby reducing warpage. Solder resist areas are formed on central portions of the contacts to promote uniformity of solder volume. As a result of these features, substantial coplanarity of the BGA array along the mounting interface of the connector is achieved.
Patent DE-69829339-T2 (DE)
Inventor: CATRON H
IPC: A23K1/175
Filed: 1998-01-30
Granted: 2006-04-06
Abstract: The present invention relates to metal carboxylates and more particularly to chromium(III) and manganese(II) salts of short chain fatty acids. A method of making the same such that there are only sub part per billion amounts of these metals in other valent forms present in the resultant salts, and the salts are suitable for use as nutritional supplementation of living organisms with the organic metal salts.
Patent DE-69900423-T2 (DE)
Inventor: CESBRON JEAN
IPC: E06B3/48
Filed: 1999-03-19
Granted: 2002-07-11
Abstract: The panel (7) which is specially intended for an up-and-over garage door is installed on another similar panel by pivoting around an axis parallel to the longitudinal horizontal direction. The panel includes first (16) and second (17) facings, rigidly fixed together, which define its large external parallel surfaces (18,19). A longitudinal edge (14) has a continuously decreasing thickness from the external surfaces as far as its free longitudinal edge (21). The transverse section of the edge is pseudo triangular.
Patent DE-69901993-T2 (DE)
Inventor: RAMIN ROLAND
IPC: A61K8/73
Filed: 1999-10-18
Granted: 2003-02-27
Abstract: The method of reducing the drying time of nail varnish comprises introducing cellulose ester as component of nail varnish composition.   Cellulose ester is used in a nail varnish composition, comprising, in solvent medium, a polymeric system containing at least 50 wt.% of nitrocellulose (per total wt. of nitrocellulose and cellulose ester), film-forming auxiliary polymer and colorant. Cellulose ester is used in effective and synergic quantity (relative to nitrocellulose content) to reduce drying time of varnish. Solvent medium preferably contains at least one organic solvent. The composition preferably contains at least one plasticizer, and does not contain silicone drying agent.
Patent DE-69910790-T2 (DE)
Inventor: CORDICK ANNE
IPC: D06M16/00
Filed: 1999-07-13
Granted: 2004-07-08
Abstract: The present invention provides in one aspect for a method for controlling odor associated with spills of organic material which can cause odors on carpets. The method comprises applying to the carpet a preparation of dormant bacteria, which when activated are effective to control odors. The dormant bacterial preparation is allowed to become associated with the carpet, such that when the carpet is exposed to organic material which can cause odors, the bacteria are capable of becoming active and digesting the organic material. The formulation may contain other agents such as odor neutralizing or masking agents, enzymes, foaming or anti-foaming agents.
Patent DE-69924567-T2 (DE)
Inventor: GREENWALD D
IPC: A61B5/0478
Filed: 1999-01-25
Granted: 2006-02-16
Abstract: Disclosed is an electrode array (i.e., "sensor") and a method for separating near and far-field signals. In one embodiment a horizontal array is used, and in an alternate embodiment a vertical array is used. The electrode array consists of two well-separated pairs of closely spaced electrodes (and a separate ground element). In a typical application of collecting a channel of EEG, "sensing" electrodes are placed in standard locations (e.g., R and Ctr) with a ground electrode placed elsewhere on the head. The voltage measured between the well-separated sensing electrodes is the far-field dominant (i.e., EEG-dominant) channel. Additional electrodes are placed near each of the two sensing electrodes. (The additional electrodes are immediately lateral to the existing electrodes in the horizontal array, and are immediately above the existing electrodes in the vertical array.) The voltages measured between the pairs of closely spaced electrodes are near-field dominant (i.e., EMG/EOG-dominant) channels. The EEG, EMG and EOG signals can be enhanced by uncoupling them by combining information from all channels. The sensor is connected to a monitor via a patient interface cable (PIC). The sensor contains additional circuitry at the connection site that is used by the monitor to identify the presence and type of sensor, and to configure the monitor to invoke the appropriate software that will apply the method of the current invention to collect and uncouple the EEG, EMG and EOG.
Patent HU-E031505-T2 (HU)
Title: Method of producing a cationic liposomal preparation comprising a lipophilic compound
Inventor: MUNDUS CARSTEN
IPC: A61K47/34
Filed: 2003-06-26
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a cationic liposomal preparation comprising a lipophilic active compound with improved physical and chemical stability and pharmaceutical acceptability.SOLUTION: The method for producing a cationic liposomal preparation comprising at least one amphiphile selected from cationic lipids of at least about 30 mol%, optionally at least one other amphiphile of up to about 69.9 mol%, a lipophilic active compound of at least about 0.1 mol% and a stabilizing agent of about 0. 1-20% (m/v), comprises steps of preparing an organic solution comprising an organic solvent, the active compound and the cationic lipid, and optionally the other amphiphile, and an aqueous solution comprising the stabilizing agent; producing a cationic liposomal preparation from the solution; optionally homogenising the preparation at least once and/or optionally sterilizing and filtrating the preparation and dehydrating the preparation; and optionally reconstituting the cationic liposomes in an aqueous solution.
Patent TR-200002025-T2 (TR)
Inventor: MARTINENGO ANTONIO
IPC: H01F/
Filed: 1998-02-12
Abstract: A transposed cable (1) is disclosed comprising a core (2) consisting of a plurality of flattened wires (3) disposed in mutually superposed relationship to form two stacks (4a, 4b) arranged parallelly and side by side, the flattened wires (3) located at the base and on top of said stacks (4a, 4b) being cyclically transposed from one stack to the other. One or more thread-like elements (6a, 6b) of polyester or any other appropriate material are helically wound around the core (2), optionally in opposite winding directions. At least one ribbon-like element (7) of paper or other material is wound over the thread-like elements (6a, 6b) and superposed thereon, said ribbon-like element being tearable by means of a tear thread (8) longitudinally interposed between the paper ribbon (7) and the thread-like elements (6a, 6b) wound over the core (2). The tear thread (8) is used to remove the paper ribbon (7) when the cable (1) is wound around a winding core (23) to make an electric winding. <IMAGE>
Patent DE-602004003712-T2 (DE)
Inventor: MUTSAARTS PHILIPPE
IPC: B22D41/28
Filed: 2004-07-20
Granted: 2007-10-18
Abstract: A method for deciding objectively whether a refractory plate of a slide gate valve used to control the flow of a molten metal during the pouring of the metal from an upper vessel to a lower vessel can be reused or should be discarded. Values of parameters measured during pouring or proper to the plate are determined during successive uses of the plate. The values are compared to threshold values to reach a decision. Also, a device for making decisions according to this method.