baber/WOPTO huggingface dataset:
Patent EP-1255769-B1 (EP)
Inventor: LIN XINLI
IPC: A61K39/00
Filed: 2000-12-28
Granted: 2007-05-02
Abstract: A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The method has two key steps to unfold and then refold the proteins expressed in the inclusion bodies. The first step is to raise the pH of the protein solution in the presence of denaturing agents to pH greater than 9, preferably 10. The protein solution may be maintained at the elevated pH for a period of up to about 24 hours, or the pH immediately decreased slowly, in increments of about 0.2 pH units/24 hours, until the solution reaches a pH of about 8.0, or both steps used. In the preferred embodiment, purified inclusion bodies are dissolved in 8 M urea, 0.1 M Tris, 1 mM glycine, 1 mM EDTA, 10 mM beta-mercaptoethanol, 10 mM dithiothreitol (DTT), 1 mM redued glutathion (GSH), 0.1 mM oxidized glutathion (GSSG), pH 10. The absorbance at 280 nm (OD280) of the protein solution is 5.0. This solution is rapidly diluted into 20 volumes of 20 mM Tris base. The resulting solutin is adjusted to pH 9.0 with 1 M HCl and is kept at 4° C. for 24 hr. The pH is adjusted to pH 8.8 and the solution is kept at 4° C. for another 24 hrs. This process is repeated until the pH is adjusted to 8.0. After 24 hr at pH 8.0, the refolded proteins can be concentrated by ultrafiltration and applied to a gel filtration column for purification.
Patent EP-1125863-B1 (EP)
Inventor: REITMEIER FRANZ
IPC: B65D83/00
Filed: 2001-01-04
Granted: 2004-08-11
Abstract: The cylindrical package for pastes has a sleeve (2) made by bending a cardboard sheet and with an axial seam (3). The lid (4) is dish-shaped and sealed at its edge (6) to the sleeve. The base (5), which contains a valve aperture (8), is also dish-shaped and its outer edge (10) fits into a lip (11) around the base of the sleeve.
Patent EP-1249246-B1 (EP)
Inventor: FINZER PATRICK
IPC: A61K31/19
Filed: 2001-04-10
Granted: 2005-09-28
Abstract: In the preparation of a medicament for the treatment of diseases associated with an human papillomavirus (HPV) infection histone deacetylase inhibitor is used. ACTIVITY : Cytostatic; Dermatological; Virucide. MECHANISM OF ACTION : Cell growth inhibitor; Cell proliferation inhibitor. To evaluate the effect of sodium butyrate (histone deacetylase) (HDAC) inhibitor on HPV16/18-induced carcinogenesis, the HPV18-positive cervical carcinoma cell line HeLa as well as primary human foreskin keratinocytes, which were separately immortalized with amphotropic retroviruses carrying the open reading frames of HPV16 E6, E7 or E6/E7 were used. To detect the effect of HDAC on cell proliferation, flow cytometric analysis on cellular DNA was carried out. It was observed that the treatment with sodium butyrate (6 mM) for 6 hours resulted in a significant increase of G1 fraction (from 56.8% to 75.7%) whereas the number of cells in S-phase was diminished from 24.9% to 8.5%.
Patent EP-1166901-B1 (EP)
Inventor: ROTHENBERGER HELMUT DR-JUR
IPC: E03F9/00
Filed: 2001-05-17
Granted: 2006-04-19
Abstract: A spring shaft ( 1 ) for cleaning pipelines consists of a coil spring ( 2 ) with windings ( 3, 3 a , 3 b , 3 c) of spring steel and with a rotation axis (RA) and a spiral winding axis (WA). In order to give the spring shaft ( 1 ) a particular cleaning function, the windings ( 3, 3 a , 3 b , 3 c) have at least on their outside ( 4 ) a cross section departing from the circular shape, with at least one edge (K) acting on the pipeline. At the same time it is possible to provide the outside ( 4 ) with at least one longitudinal groove ( 8 ) following the windings ( 3 c), or to configure the cross section of the windings ( 3 a , 3 b) as a square whose outside edge ( 4 a) runs parallel to the rotation axis (RA) or whose surface diagonal ( 4 b) runs radially to the rotation axis (RA). Lastly, it is possible to provide the outside ( 4 ) with a profile ( 5 ) in which projections and grooves alternate.
Patent EP-1287905-B1 (EP)
Inventor: HESS JOSEPH
IPC: B05B1/30
Filed: 2001-09-03
Granted: 2006-08-23
Abstract: The invention concerns a liquid droplet spray device for atomising a liquid substance, comprising a housing comprising a first substrate, a second substrate superposed on the first substrate and a space enclosed by said first and second substrates for containing the liquid substance. <IMAGE>
Patent EP-1215641-B1 (EP)
Inventor: TASKULA KARI
IPC: G08G1/095
Filed: 2001-12-13
Granted: 2006-03-08
Abstract: An apparatus for monitoring and/or controlling a traffic control light, the light source of said control light consisting of LEDs (2) connected on a circuit board (1), said control light being controlled by means of a control unit, and said control light comprising a lens dome part (3) which is fitted in front of the LEDs and contains transparent light directing elements (4), and said apparatus comprising detectors (5) disposed in connection with the LEDs used as light sources on the same side of the circuit board (1) with these, some of the light reflected from the LEDs being directed to said detectors, which are used to provide optical feedback for the monitoring and/or control of the operation of the control light. The apparatus comprises non-transparent reflectors (6) arranged between the light directing elements to reflect some of the light emitted by the LEDs (2) in the direction of illumination to the detectors (5). <IMAGE>
Patent EP-1139361-B1 (EP)
Inventor: BERT MICHEL
IPC: H01H1/60
Filed: 2001-02-09
Granted: 2007-03-28
Abstract: An electrical circuit for transmitting an item of information relating to the state of a parameter or of a piece of equipment, in particular for application in the railway field. The circuit includes a device for regulating the current flowing through the switch, including a switch device for switching over connections and having an inductive energy storage device and a capacitive energy storage device which, under steady conditions, alternate between being a device for storing and a device for restoring a fraction of the energy of the electrical circuit depending on the alternating state of the connections, as defined by the switch device. The invention also provides an electrical system incorporating such a circuit.
Patent EP-1145793-B1 (EP)
Inventor: SAURON JEAN
IPC: B23K37/04
Filed: 2001-03-12
Granted: 2006-02-01
Abstract: The arc welding machine uses coated rods (31) for the repair of railway rails and has a chassis (3) with a welding head having a arc generator (7) and a control (9) for the welding process. The chassis has at least two legs (11a,b) to engage a rail. The legs and the arc generator are aligned for automatic alignment f the machine along the rail (13) to be welded. The arc generator can move along at least two transverse axes (X, Y). The generator can be mounted on a support (25) with controls to regulate the height and angular position of the arc. AN Independent claim is also included for a method of repairing rails using the machine
Patent EP-1225747-B1 (EP)
Inventor: JOHANSSON STEFAN
IPC: H04W4/00
Filed: 2001-01-17
Granted: 2006-03-22
Abstract: The present invention relates to methods, apparatuses and a system in connection with pushing of packet data from an originator to a wireless communication station 20. When a network address is received by the wireless station 20 from a server 50 wishing to push packet data to the wireless station, the received network address is checked against stored predefined network addresses. If the received network address is found among the stored network addresses, the originator is verified, preferably by using an address translation server 40. Thus, in this way it can be determined that the originator indeed belongs to a predefined set of originators from which a mobile user wants to accept pushed packet data transmissions. A packet data session is then established by the wireless station with a verified originator in order to receive the packet data. <IMAGE>
Patent EP-1258251-B1 (EP)
Inventor: ARAKI HIROMASA
IPC: A61K38/08
Filed: 2001-02-20
Granted: 2009-04-15
Abstract: The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases. <IMAGE>
Patent EP-1255627-B1 (EP)
Inventor: MOELLER BERND
IPC: B23Q1/00
Filed: 2001-02-02
Granted: 2004-08-25
Abstract: The invention relates to a spindle ( 9 ) for a machine tool, having a housing ( 12 ) to accommodate an electric motor ( 11 ) and a shaft ( 13 ) driven by the latter and having a tool holder for a tool ( 10 ) for machining workpieces, at least one data acquisition element ( 2 ) being provided to record operating and/or state data of the spindle ( 9 ), and at least one spindle-integrated data storage element ( 1 ) being provided to store the recorded data from the data acquisition element ( 2 ).
Patent EP-1181755-B1 (EP)
Inventor: HILLEBRAND DIETMAR
IPC: H02B1/04
Filed: 2001-03-16
Granted: 2009-08-26
Abstract: The connector is provided by an anchor-shaped connector clip (1) received in one electrotechnical component (13) to be connected, with a base of the connector clip fitted into a reception groove (7) and an anchor bar of the connector clip provided with snap-in sections at both ends, received within an undercut recess in the second electrotechnical component (14). A connector clip retention slides into the reception groove for securing the connector clip in the closed position.
Patent EP-1269694-B1 (EP)
Inventor: GORTI BRAHMANAND KUMAR
IPC: H04Q11/04
Filed: 2001-03-30
Granted: 2005-02-23
Abstract: A method and system for controlling a plurality of sub-pipes in a computer network is disclosed. The computer network includes at least one switch. The plurality of sub-pipes utilizes the switch for transmitting traffic through the network. The method and system include allowing a minimum flow to be set for each of the plurality of sub-pipes and determining whether congestion exists for the pipe. The method and system also include controlling a flow in a sub-pipe of the plurality of sub-pipes only if congestion exists. Once congestion is determined to exist, the time set to control of sub-pipes is set significantly longer than for control over individual decreases or increases of the flows in sub-pipes. The flow is controlled such that the flow for the sub-pipe may be linearly increased if the flow for the sub-pipe of the plurality of sub-pipes is less than the minimum flow. The flow is also controlled such that the flow for the sub-pipe of the plurality of sub-pipes is exponentially decreased if the flow is greater than the minimum flow. In determining whether to increase or decrease the flow in a sub-pipe, a second definition of congestion may be used. Thus the traffic through the switch is stable.
Patent EP-1276500-B1 (EP)
Inventor: MULLER WILLIAM A
IPC: A61K39/395
Filed: 2001-03-13
Granted: 2011-06-08
Abstract: The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.
Patent EP-1269447-B1 (EP)
Inventor: KAVNER DOUGLAS M
IPC: G08G1/16
Filed: 2001-03-14
Granted: 2004-12-22
Abstract: A system and method for detecting incidents along a roadway are provided. A plurality of readers are spaced at intervals along a roadway for reading uniquely identified data from each of a plurality of vehicles. These readings are correlated to obtain information on each of the vehicles and to determine the number of vehicles potentially affected by incidents along the roadway. Finally, the number of each of the vehicles potentially affected by incidents is compared to a sample threshold in order to determine if a traffic incident has occurred.
Patent EP-1374375-B1 (EP)
Inventor: PARK KYEONG-BAE
IPC: H02K33/16
Filed: 2001-05-24
Granted: 2011-07-27
Abstract: A reciprocating motor comprises a mover (400) including an opening unit formed as a ring with an opening on (110) its one side; a first stepped unit (120) in which the inner interval of the opening (110) unit is narrowed gradually toward the entrance; and a second stepped unit (130) continued with the first stepped unit (120) and forming the entrance of the opening unit. According to that, the length of the permanent magnet (420) is decided and the entrance width of the opening unit in which the winding coil (300) is located is reduced, thereby the amount of high price permanent magnet used is reduced, reciprocating movement of the mover getting out of the outer core is minimized, flux on the outer core and the inner core flows smoothly, and leakage of the flux is reduced so the function of the motor can be improved.
Patent EP-1310114-B1 (EP)
Inventor: SKOG ROBERT
IPC: H04L12/28
Filed: 2001-07-06
Granted: 2006-10-04
Abstract: Communication system comprising a terminal 2, e.g. a mobile phone, adapted to access information in an application server via an access network using an access bearer. The system conveys the capability of the access bearer to the application in order to tailor the information content depending on the capability of the bearer that is used for the specific access.
Patent EP-1370727-B1 (EP)
Inventor: MAEENPAEAE TAPIO
IPC: D21G1/00
Filed: 2001-08-23
Granted: 2006-08-23
Abstract: The invention relates to a method for controlling a surface quality variable ( 300 ) in one or more fiber webs ( 3 ) in a shoe calender ( 1 ) comprising one or more calender nips. In each calender nip of the shoe calender, the overall loading pressure of the shoe element ( 8 ) and the loading pressure difference between the leading edge ( 8 ') and the trailing edge ( 8 '') of the shoe element are controlled so as to achieve minimum difference between the determined values ( 300 '') for the surface quality variables of the fiber web and the set values ( 300 ') for the same quality variables after the shoe calender.
Patent EP-1303564-B1 (EP)
Inventor: HARVEY HEATHER BLUE
IPC: C08K5/00
Filed: 2001-06-28
Granted: 2004-03-10
Abstract: The invention relates to a stabiliser system and the use thereof in the processing of vinyl chloride (co)polymers, said stabiliser system comprising at least the salt of specific hydroxyacid and one or more colour stabilisers. Stabilised PVC, obtainable by compounding said stabiliser system into said vinyl chloride (co)polymer, shows good colour and heat stability, while preferred stabiliser systems also are allowed to be used in food-grade, including drinking water-grade, PVC applications.
Patent EP-1313448-B1 (EP)
Inventor: ANDERSON RICHARD ROX
IPC: A61K41/00
Filed: 2001-08-13
Granted: 2010-04-07
Abstract: Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.
Patent EP-1334399-B1 (EP)
Inventor: NG DAVE
IPC: G02C9/04
Filed: 2001-10-31
Granted: 2009-08-26
Abstract: An auxiliary spectacle apparatus is provided wherein auxiliary lenses have a mechanical bridge fastener for releasably engaging the bridge portion of the primary frames in a manner which provides security of attachment in all directions.
Patent EP-1337607-B1 (EP)
Inventor: SCHMID CHRISTOPH
IPC: C10J3/46
Filed: 2001-11-08
Granted: 2006-06-07
Abstract: The invention relates to a method for gasifying liquid to pasty organic substances and substance mixtures. According to the invention, the organic substances are converted to a substantially volatile phase in a pyrolysis reactor by contacting them with a hot heat transfer medium. Once a reactant such as water vapor is optionally added, the volatile phase is heated up in a second reaction zone, configured as a moving bed reactor, to such an extent that a product gas with a high calorific value is obtained. The heated up and partially reacted gas mixture is fed to a third reaction zone in which it finally reacts with a catalytically active material, heated up to reaction temperature and different from the heat transfer material, to give the product gas. A flow of hot residual gases of the furnace is used to heat up the heat transfer medium while being cooled.
Patent EP-1256455-B1 (EP)
Inventor: GOTO FUMITAKA
IPC: B41M5/00
Filed: 2002-05-08
Granted: 2008-09-24
Abstract: An ink jet recording method for effecting recording on a recording material by ejecting ink comprising coloring material and reaction liquid reactable with the ink from an ink ejection portion for ejecting the ink and a reaction liquid ejection portion for ejecting the reaction liquid, the method including a recording step of effecting the recording selectively in a first recording mode in which no blank is provided at least one end portion on a surface of the recording material and a second recording mode in which no blank is provided at any of end portions of the surface of the recording material; wherein a recording condition in the first recording mode and a recording condition in the second recording mode is different. <IMAGE>
Patent EP-1304205-B1 (EP)
Inventor: WILDSCHUT RUDOLPH LEONHARD
IPC: F16L47/32
Filed: 2002-10-02
Granted: 2005-08-31
Abstract: Method for forming a joint between a coupling sleeve (1, 1', 1", 35, 35', 36, 36', 38, 38'), of the type with two or more tubular connection ways (2, 4, 6) for pipes for distribution of a fluid, and one or more pipes (9) for distribution of a fluid, characterised in that it comprises the following phases:     provision of a tubular core (3) of the coupling sleeve (1); head pressure-engaging of each of said one or more pipes (9) on a corresponding tubular way (2, 4, 6) of the core (3) of the coupling sleeve (1); and over-moulding of a body (5) of the coupling sleeve (1) on the tubular core (3) of the coupling sleeve(1), said over-moulded body (5) of the sleeve (1) covering completely or at least partially the external side of the length of intersection between each of said one or more pipes (9) and the corresponding tubular way of said core (3) of the coupling sleeve (1).   <IMAGE>
Patent EP-1428585-B1 (EP)
Inventor: GEHRIG JEAN
IPC: C03C23/00
Filed: 2002-12-13
Granted: 2006-05-10
Abstract: The device has a chassis with a horizontal bar (1) in a cylindrical shape and supporting pins (2). The pin has a central stem (20) forming a body of the pin. The stem is held sticking to the bar in a removable manner, by hooks (21,22). Branches (23,24) avoid the free rotation of the pin around the bar. Position maintaining unit (3) maintains the position of glass parallel to the axis of the central stem.
Patent EP-1324002-B1 (EP)
Inventor: SCHULZ GEORG
IPC: F16H25/20
Filed: 2002-12-19
Granted: 2011-06-15
Abstract: The device determines the actual length of the linear drive using a linear sensor (4) for providing a signal proportional to the linear movement of the drive spindle (1). The sensor has a measuring rod (41) extending in the axial direction of the spindle, with a length at least equal to the maximum displacement of the linear drive and a cooperating position source (42) attached to the load-free end of the drive spindle.
Patent EP-1284301-B1 (EP)
Inventor: STROBEL RICHARD W
IPC: C22C13/00
Filed: 2002-02-06
Granted: 2007-07-11
Abstract: The present invention relates to a coating to be applied to an electrically conductive material, said coating consisting of more than 1,0 wt% to 20 wt% silver and the balance essentially tin and having a melting point greater than 225  DEG C.
Patent EP-1277537-B1 (EP)
Inventor: VERZELETTI MAURO
IPC: B23K37/053
Filed: 2002-07-12
Granted: 2005-09-14
Abstract: This invention concerns a machine for cutting pipes (13) of different cross-section and diameter by means of a laser beam, comprising a laser source and a system of mirrors for directing the laser beam from said source to a cutting head (7) for focalising said beam on a pipe (13) to be cut through a relevant mirror. The cutting head (7) is fitted rotating on an arm (3) hinged on a bearing ring (4) said bearing ring being on board a carriage (5) sliding on a system of guide rails (8) that can move parallel to the pipe (13) to be cut. The rotation of the cutting head (7) and of the arm (3) and the movements of the carriage (5) and guide rail system (8) are coordinated by a control unit in such a way that the cutting head (7) always aims the laser beam at right angles with respect to the surface of the pipe (13) to be cut. The machine also features an extraction unit for the fumes produced by the pipe cutting operation, said unit being intended to receive the end of the pipe downstream of arm (3) and being susceptible to movement along a rail parallel to said pipe (13). <IMAGE>
Patent EP-1427790-B1 (EP)
Inventor: DE COOMAN RIA
IPC: C09J175/16
Filed: 2002-03-07
Granted: 2009-10-21
Abstract: Described are adhesive compositions comprising   (i) at least one reactive monomer (A) selected from ethylenically unsaturated carboxylic acid derivatives and mixtures of such derivatives; said one or more derivatives preferably being one or more esters, (ii) at least one liquid elastomer in a molar weight range of 1000 - 9000 which is functionalized with ethylenically unsaturated groups (B),   (iii) at least one impact modifier (C), and (iv) at least one free radical initiator and at least one catalyst, whereby optionally either said initiator ,or said catalyst is present separately, in a further component or paste, respectively, whereby the amounts of A, B, and C preferably are as follows, namely     B referred to the total amount of A+B = 15 - 60 % by weight, and C referred to the total amount of A+B+C = 5 - 30 % by weight.
Patent EP-1350287-B1 (EP)
Inventor: STEINER ERNST
IPC: H05K3/40
Filed: 2002-01-11
Granted: 2008-10-08
Abstract: A method and device for making multiple connections between electrical conductors surrounded by external insulators in overlapping flexible cables by ultrasonic welding. Overlapping conductors to be connected are arranged on a surface of a carrier disposed between a sonotrode and an electrode, the sonotrode and electrode are sequentially aligned the with overlapping points to be welded, and the conductors are ultrasonically welded at each of the overlapping points. The carrier either includes the electrode at least in designated areas, or includes penetrations constructed and arranged to receive an electrode in designated areas.