baber/WOPTO huggingface dataset:
Patent PT-775159-E (PT)
Inventor: CERLETTI NICO
IPC: C07K14/495
Filed: 1995-07-12
Abstract: The present invention relates to a folding process for the preparation of biologically active, dimeric TGF- beta  (Tranforming Growth Factor type  beta )-like protein.
Patent PT-743519-E (PT)
Inventor: MALIN MICHAEL J
IPC: G01N33/50
Filed: 1996-05-03
Abstract: The present invention provides an improved reagent composition and method to perform white blood cell differential counting and subpopulation analysis using both fresh and aged blood samples with accuracy and precision. The invention is particularly applicable for the analysis of aged blood samples that have been stored at room temperature for over a day, thereby allowing accurate and useful information to be obtained from samples that are normally considered to be suboptimal. The improved reagent composition and method are particularly related to the peroxidase method of white blood cell differential determinations. One aspect of the invention includes an improved aqueous reagent composition for carrying out the peroxidase method of differential counting. Another aspect includes the use of a rinse cycle and rinse solution devoid of hemolytic surfactant to alleviate the adverse effects of rinse carryover and to streamline and economize the analytical process, particularly when the analyses are performed on automated hematology analyzers and flow cytometry systems. The composition and method of the invention provide clinically useful data for the differential analysis of whole blood samples.
Patent PT-818996-E (PT)
Inventor: RAMTOOLA ZEBUNNISSA
IPC: A61K9/16
Filed: 1996-04-02
Abstract: A controlled release pharmaceutical formulation which comprises cyclosporin entrapped in a biodegradable polymer to form microspheres or nanospheres such that the cyclosporin is substantially in an amorphous state and the biodegradable polymer comprises greater than 12.5% w/w poly(lactide). The biodegradable polymer is suitably poly-D,L-lactide or a blend of poly-D,L-lactide and poly-D,L-lactide-co-glycolide. Additionally, an enteric coating can be applied to the microspheres or nanospheres or to the oral dosage form incorporating the microspheres or nanospheres to protect the formulation while it passes through the stomach. A particularly suitable formulation comprises 50% w/w cyclosporin-loaded 80:20 blend of poly-D,L-lactide-co-glycolide to poly-D,L-lactide micro- and/or nanospheres. This formulation has the combined properties of nearly complete but relatively slow release of cyclosporin within 8 hours and is useful for targeting cyclosporin to the small intestine when administered orally.
Patent PT-839028-E (PT)
Inventor: HAEBERLIN BARBARA
IPC: A61K31/436
Filed: 1996-07-12
Abstract: A pharmaceutical composition for oral administration in the form of a solid dispersion comprising an ascomycin or a derivative thereof and a carrier medium.
Patent PT-798325-E (PT)
Inventor: GERBER ULRICH
IPC: C08G18/42
Filed: 1997-03-27
Abstract: Binders (BM), containing compound(s) of formula (I) HÄ)-R1-C(=O)-ÜnAÄ(R4)yÜ-ÄR2O-C(=O)-R3Üx (I) and/or(II) R3C(=O)-ÄOR1C(=O)ÜnAÄ(R4)yÜ-ÄR2OHÜx (II) where -O-R1-CO- is a polyester repeat unit containing at least one aromatic group; n = 1-4; A = O or N; x = 1 or 2; y = 0 or 1, x + y = 2 if A = N; x = 1 and y = 0 if A = O; R1 = aromatic polyester segment, especially from condensation of an aromatic diacid and an optionally substituted aliphatic glycol; R2 = optionally OH-substituted aliphatic, cyclic or aromatic 1-8C hydrocarbylene, di-, tri- or tetra-alkyl ether group or ester or polyester derived from aliphatic or aromatic carboxylic acid(s) and aliphatic alcohols and/or glycols; R3 = saturated or unsaturated 11-21C alkyl, substituted with OH group(s); R4 = H or hydroxyalkyl. Also present is at least one compound of the group HO-R2-OH, HO-R2-NH2, HO-R2-NH-R2-OH, HO-R2-O-CO-R3 or Q(O-CO-R3)p, in which Q = optionally OH-substituted 3-6C alkyl, and p = 1-4. Also claimed is a process for the production of BM, by (i) reacting an aromatic polyester containing repeat units of formula -O-R1-CO- with a polyol of formula HO-R2-OH and then (ii) reacting the product with a fatty acid ester of formula Q(O-CO-R3)p (III).
Patent PT-827745-E (PT)
Inventor: BISSERY MARIE-CHRISTINE
IPC: A61K33/243
Filed: 1993-11-08
Abstract: Combinations of (a) taxol, taxotere, or their derivatives, with (b) a therapeutic substance are used in the treatment of neoplastic disorders. Pref., (b) is an alkylating agent, (esp. cyclophosphamide, ifosamide, melphalan, hexamethyl melamine, thiotepa, and dacarbazine), an anti-metabolite, (esp. 5-fluorouracil, cytarabin, methotrexate, idatrexate, and trimetrexate), a fusel poison (esp. a vinca alkaloid, their synthetic and semi-synthetic analogues, estramustine, and taxoids), an epidophyllotoxin, (esp. etoposide or teniposide), an antibiotic, esp. daunorubicin, doxorubicin, bleomycin, or mitomycin), an enzyme (esp. L-asparaginase), a topoisomerase inhibitor, (esp. camptothecin, CPT-11, topotecan, and pyridobenzoindole derivatives), procarbazine, mitoxantrone, platinum coordination complexes (esp. cisplatin and carboplatin), biological response modifiers and growth inhibitors, (esp. interferons and interleukins), and haematopoietic growth factors. The taxane derivative (a) may comprise 10-90% of the active materials.
Patent PT-904063-E (PT)
Inventor: MESENS JEAN LOUIS
IPC: A61K/
Filed: 1997-05-06
Abstract: The invention provides a particulate material comprising microparticles of a biodegradable biocompatible polymeric matrix containing an active agent and an organic solvent, said organic solvent being present in said microparticles at 2% or less of the total weight of said microparticles.
Patent PT-910261-E (PT)
Inventor: CHATAIGNIER BERNARD
IPC: A47C1/12
Filed: 1997-05-09
Abstract: A row of at least two seats including a supporting structure (30), seat members (20) mounted thereon, and a housing combined with said supporting structure for receiving cables or ducts (46), is disclosed. Said housing is defined by a channel section (40) extending along a plurality of seats and capable of being opened in such a way that said section may be accessed substantially along the whole length thereof. The system is particularly useful for simplifying wiring arrangements in seats provided with various fittings, especially in public places.
Patent PT-905333-E (PT)
Title: Electrically-operated multiple folding stage system
Inventor: FUJITA KAZUO
IPC: A63J1/00
Filed: 1998-09-07
Abstract: An electrically operated multiple folding system which enables a number of linked stage systems (X1,X2) to move sequentially from a vertical to horizontal position (unfolding), or from a horizontal to a vertical position (folding-up), as a unit in a single smooth operation. The proposed system acts to ensure that operation occurs without interference or occlusion. A stay (21) is projected from the rear end of the link (L2) which folds the stage leg (7B) positioned under the rear stage (S2) of the front stage system (X1), and is linked via a link shaft to a stage leg (7C) positioned across the width of the foremost row under the front stage (S3) of the rear stage system. <IMAGE>
Patent PT-1000043-E (PT)
Title: A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent
Inventor: SNAPE EVAN WILLIAM
IPC: C07D417/04
Filed: 1998-07-28
Abstract: Crystalline 11-(4-Ä2-(2-hydroxyethoxy)ethylÜ-1-piperazinyl)-dibenzoÄb,fÜÄ1,4Üthiazepine may be prepared by crystallising 11-(4-Ä2-(2-hydroxyethoxy)ethylÜ-1-piperazinyl)-dibenzoÄb,fÜÄ1,4Üthiazepine from a non-aromatic solvent such as ethyl acetate, isobutyl acetate, methyl iso-butylketone or methyl tert-butyl ether, preferably in the absence of water. The crystalline material produced may be converted into a pharmaceutically acceptable salt such as a fumarate. The crystalline 11-(4-Ä2-(2-hydroxyethoxy)ethylÜ-1-piperazinyl)-dibenzoÄb,fÜÄ1,4Üthiazepine may be used to treat psychoses.
Patent PT-979713-E (PT)
Inventor: MOHR WINFRIED
IPC: B28B7/24
Filed: 1999-05-28
Abstract: The sleeper production process involves cleaning the molds at a preparation point (1) and fitting the with armature if required before filling them at a concreting and shaking-down point (2). The sleepers are set by a heat treatment process. The sleepers are made in multiple molds and the heat treatment is in heat chambers (16-29).
Patent PT-989181-E (PT)
Title: Process for producing essential oils via treatment with supercritical water and essential oils obtained by treatment with supercritical water
Inventor: MIKI WATARU
IPC: A23L27/10
Filed: 1999-04-09
Abstract: The present invention provides a novel process for producing an essential oil from a plant material. Concretely, the process produces an essential oil in a short time and by a simple procedure by treating a plant material with supercritical water or subcritical water to liberate essential oil components, which are contained in the plant material, as an ester-free essential oil, and separating and purifying this essential oil.
Patent PT-1141069-E (PT)
Inventor: FENN DAVID ROBERT
IPC: B05D7/24
Filed: 1999-12-23
Abstract: A coating composition comprising; i) a polymer having uretdione groups, and ii) a polyamine crosslinker.
Patent CA-2729619-F (CA)
Title: Nutritive compositions and methods of using same
Inventor: MOORE EILEEN
IPC: A61P3/02
Filed: 2009-07-07
Granted: 2010-01-14
Abstract: The invention provides intradialytic parenteral nutrition (IDPN) solutions with low carbohydrate for the treatment of malnutrition in dialysis patients. The IDPN solutions of the invention are particularly advantageous for the treatment of malnutrition in patients who are diabetic or suffer from other glucose management related pathologies or patients who require strict fluid management.
Patent SG-26368-G (SG)
Title: Phenylcyclohexanes and liquid crystal medium
Inventor: WAECHTLER ANDREAS
IPC: C07C22/08
Filed: 1990-08-13
Abstract: Novel phenylcyclohexanes of the formula I in which n is 0 to 7, Q<SUP>1 </SUP>and Q<SUP>2 </SUP>are H, or one of these radicals is alternatively CH<SUB>3</SUB>, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, -CF<SUB>3</SUB>, -CN, -OCF<SUB>3 </SUB>or -OCHF<SUB>2</SUB>, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q<SUP>1</SUP>=Q<SUP>2</SUP>=H and simultaneously X=CN, Y and/or Z are F.
Patent IE-880180-L (IE)
Title: Acylation process for alpha,omega-diamino acids
IPC: C07C233/36
Filed: 1988-01-25
Abstract: A process for the N- omega -trifluoroacetylation of a saturated aliphatic monocarboxylic  alpha , omega -diamino acid. A saturated aliphatic monocarboxylic  alpha , omega -diamino acid of the formula: <IMAGE>  wherein R represents a straight-chain or branched-chain C1-C6 alkylene radical, is contacted with a C1-C6 straight-chain or branched-chain alkyl trifluoroacetate.
Patent IE-790507-L (IE)
Title: Frame for supporting a door and a window
IPC: E06B1/02
Filed: 1987-04-07
Abstract: An extruded frame member for supporting a door 34 and a window 27 comprises a hollow main body portion 11, a first continuous recess 12 along one side of the main body portion for accommodating a window- carrying frame 14, and a second continuous recess 15 along the opposite side of the main body portion having a restricted opening for slidably accommodating one leaf of a door hinge 33, the said member being formed by extrusion. <IMAGE>
[GB2201182A]
Patent IE-45120-L (IE)
Title: Electrolytic preparation of tetraalkylthiuram disulfides.
IPC: C25B3/29
Filed: 1977-03-09
Abstract: 1513228 Tetraalkylthiuram disulphide E I DU PONT DE NEMOURS & CO 9 March 1977 [10 March 1976] 09953/77 Heading C7B Tetraalkylthiuram disulphide is prepared by electrolyzing an anolyte of an alkali metal ammonium or quaternary ammonium dialkyldithiocarbamate salt in aqueous solution and a NaOH catholyte in a cell having a shiny Pt anode and a cation membrane impermeable to OH ions.
[GB1513228A]
Patent IE-37504-L (IE)
Title: Substituted benzamides
IPC: A61K/
Filed: 1973-04-06
Abstract: 1383269 2-Alkoxy-benzoic acid anhydrides and N-(tert.-aminoalkyl)-2-alkoxy benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 6 April 1973 [8 April 1972] 16631/73 Heading C2C The invention comprises anhydrides (including mixed anhydrides), in compounds of the formula wherein R 1 is C 1 to C 5 alkyl; R 2 is amino, acrylamino, or nitro; and X is hydrogen or halogen which may be prepared by the action of a 2-alkoxy-4-substituted benzoic acid on an organic acid or a reactive derivative thereof (except for an ester of a carboxylic acid or a halogenoformic acid ester.) The invention further comprises a method of preparing a N-(tertiary-aminoalkyl)-2-alkoxy benzamide having the formula wherein Y is a t.-aminoalkyl group, comprising reacting a compound of Formula (I) with an amine or the salt of a N-(t.-aminoalkyl)amine having the formula H 2 N-Y (II).
[GB1383269A]
Patent IE-870738-L (IE)
Title: Improvements in or to antibiotic
IPC: C12P21/02
Filed: 1987-03-20
Abstract: A means for increasing the antibiotic-producing ability of an antibiotic-producing microbial host cell is disclosed. The method involves transforming an antibiotic-producing microorganism with a recombinant DNA cloning vector that codes for the expression of a rate-limiting antibiotic biosynthetic enzyme or other gene product.
Patent IE-34353-L (IE)
Title: Vibration-damping devices
IPC: F16F7/108
Filed: 1970-06-30
Abstract: 1311718 Engine mountings REGIE NATIONALE DES USINES RENAULT and AUTOMOBILES PEUGEOT 1 July 1970 [25 July 1969] 31784/70 Heading B7H [Also in Division F2] A tuned mass-spring type vibration damper, shown in Fig. 1 applied to the damping of a vehicle engine 1, operates on the principle of generating compensating vibrations opposed to the driving vibrations and is effective to generate such vibrations in two orthogonal directions A, B so that all vibrations in the plane containing these directions will be annulled. The mass 5 is adjustably slidable along a bar 4 which is connected by way of spring elements 6, 7 to the vibrating structure, i.e. the engine 1, and to its support, e.g. the vehicle chassis 3. The spring elements have anisotropic elastic properties such that each possesses different stiffnesses in the two directions A and B. As shown, these springs are elastomeric sleeves rendered anisotropic by cut-outs 8: leaf springs could however be employed. In either case, the springs could be made self-damping either by the incorporation of a suitable filling in the elastomeric sleeves or by resin-coating the leaf springs. The weight 5 may also be made self-damping by employing a composite weight (Figs. 2 and 3, not shown) consisting of a core surrounded by an elastic sleeve (9) in turn surrounded by a rim (10). This would damp out high harmonic vibrations outside the range of effectiveness of the mass-spring system 5-6-7.
[GB1311718A]
Patent FI-821414-L (FI)
Inventor: RULAND ALFRED
IPC: A01N47/48
Filed: 1982-04-23
Abstract: 1. A process for the preparation of iodomethyl thiocyanate, wherein chloro- or bromomethyl thiocyanate is reacted with an inorganic iodide in an organic solvent at a temperature of from 10 to 100 degrees C.
Patent FI-832234-L (FI)
Inventor: SHIBUYA MUTSUMI
IPC: G01N33/52
Filed: 1983-06-17
Abstract: A method and device for rapid diagnosis of dental caries are provided in which a test piece (1) is impregnated with a very small amount of saliva to be tested, said test piece (1) containing a dry reagent, maintained with the air intercepted to prevent evaporation of saliva for about 15-30 minutes at a temperature around 20-37°C, and a color change of the reagent due to the enzymatic reaction of the dental caries-causing microorganism is examined.
Patent FI-852208-L (FI)
Inventor: VIRTA ARTO
IPC: A61B6/14
Filed: 1985-05-31
Abstract: @ A panoramic tomography X-ray apparatus, which comprises a fixed frame (30), to which another frame (rotary frame) (11), having an X-ray tube (10) at one end and a film cartridge device (20) for X-ray film (RF) at the other end, is suspended. The apparatus has a drive mechanism forturning the rotary frame (11) in the horizontal plane for taking a panoramic X-ray photograph. In the drive mechanism there is a drive and guide groove (31), which has straight side sections (31S) and a curved section (31 R) connecting the side sections together. The drive unit (33) of the apparatus comprises a drive wheel (40) which, when rotated by the drive unit (33), turns said rotary frame (11). The rotary frame (11) is suspended to the fixed frame (30) by means of a crank mechanism (13,50,51) which is jointed to the rotary frame (11) and to the fixed frame (30) with bearings (12a, 12b; 53a, 53b). The drive and guide mechanism (33-41) and the crank mechanism interact in such a way that, in the front area of the dental arch, i.e. when the corresponding section (31 R) of the guide and drive groove (31) is in operation, the rotary frame (11) turns around the front journal pin (51) of the crank (50), and in the side areas, when guided by the straight sections (31S) of the drive and guide groove (31), the rotary frame (11) simula- taneouslyturns around both journal pins (13, 51) of the crank mechanism (13, 50, 51).
Patent FI-852708-L (FI)
Inventor: CURUTCHET JEAN LUC
IPC: C06C5/06
Filed: 1985-07-09
Abstract: A low energy fuse which has a tubular casing that is deformed at at least one end and intermediate its ends to form valve formations. Each valve formation defines a valve that is normally substantially closed and which is opened, in use, by a shock wave. Wall material of the casing may be deformed by heated displaceable forming elements. The deformed wall portions may be fused or bonded together to form an hermetic seal, the fusion or bond being sufficiently weak to be ruptured by the shock wave. Instead the deformed wall portions may merely touch one another or may be spaced slightly apart to define an aperture which is substantially smaller than the cross-sectional area of the casing.
Patent IE-801149-L (IE)
Title: Trihydroxy-piperidines
IPC: C07D211/56
Filed: 1980-06-04
Abstract: The invention relates, inter alia, to 3,4,5-trihydroxypiperidine compounds of Formula (I), infra, to methods for the manufacture of said compounds, to pharmaceutical compositions containing said compounds and to methods for the use of said compounds and compositions. Also included in the invention are concentrates, premixes and feedstuffs containing said compounds.
Patent IE-45422-L (IE)
Title: Making rigid sheet
IPC: B29C63/00
Filed: 1977-06-13
Abstract: A new method of preparing a fire-resistant sheet formed product is disclosed involving the following steps: (1) grinding together a particulate inorganic material selected from the group consisting of crystallized blistered glass, crushed cement clinkers and crushed blast furnace slags, a hydraulic binder and from 10 to 2% by weight of an organic thermosetting binder in a ball mill until the particulate inorganic material has sufficiently disintegrated and the particulate inorganic material, the hydraulic binder, and the organic thermosetting binder are homogeneously distributed to form a dry mixture of particles; (2) subjecting the dry mixture of particles to heat treatment, under pressure, to consolidate and bond the dry particles into a unitary structure to form a sheet; and (3) after release of pressure, treating the sheet with water to set and cure the hydraulic binder.
[US4202851A]
Patent IE-821215-L (IE)
Title: Business forms assemblies
IPC: B41L1/20
Filed: 1982-05-20
Abstract: The invention is concerned with a business forms assembly of the kind sometimes referred to as a "snap-out' set which may be of self manifolding paper (sometimes called self copy paper) or of record sheets (1) interleaved with transfer sheets (carbon paper sheets). The assembly comprises a plurality of interleaved sheets (1) secured together at or adjacent one edge by adhesive (2) to form a stub and with transfer material between the sheets and wherein an extension sheet part (5) extends beyond the secured stub edge to provide a means for feeding the interleaved sheets (1) into a print unit (11 to 15).
Patent IE-38042-L (IE)
Title: Generating seismic waves
IPC: G01V1/02
Filed: 1973-07-19
Abstract: An apparatus for generating seismic waves includes an elongated closed tube with a piston in its internal cavity. The piston is carried by a piston rod which extends through the top of the tube, and includes a fuel inlet and exhaust channel. The piston also carries a second tube to define a combustion chamber therein, and a fuel conducting tube extending along the length of the piston rod and beyond the piston to approximately medially within the second tube. When a combustion fuel is introduced to within the combustion chamber and ignited, a force is applied to the piston in one direction and an opposite force is applied to the tube moving the tube with respect to the piston a distance approximately three times the diameter of the piston.
[US3958661A]
Patent IE-881269-L (IE)
Title: Steroids
IPC: C07J31/00
Filed: 1988-04-28
Abstract: Compounds of formula (I) : <CHEM> in which, inter alia, R<1> is H or C1-8alkyl and M is O or S, processes for their preparation, pharmaceutical compositions containing then and their use as inhibitors of 5- alpha -reductase in the treatment in the reduction of prostate size.
[EP0289327A2]
Patent IE-45456-L (IE)
Title: Aminoalkyl furan derivatives
IPC: C07C313/00
Filed: 1977-07-25
Abstract: Novel aminoalkylfuran derivatives of the general formula I:  in which the symbols have the meaning indicated in Claim 1, are prepared by reaction of a compound of the formula  with a compound of the formula R3NZZ'. A, B, Z and Z' have the meaning indicated in Claim 1. The aminoalkylfuran derivative can be used in the form of the free base or in the form of a physiologically acceptable salt or a hydrate. These novel aminoalkylfuran derivatives exhibit inhibition of gastric acid secretion if they are stimulated via histamine H2 receptors.