baber/WOPTO huggingface dataset:
Patent EP-3996682-A1 (EP)
Inventor: AMBUEHL MICHAEL
IPC: A61K47/44
Filed: 2020-07-08
Abstract: The invention relates to pharmaceutical compositions, which are self-emulsifying, self-microemulsifying, or self- nanoemulsifying in aqueous medium, comprising the compound: 2-(2,2-Difluoro-propyl)-5-[1-(2-fluoro-6-methyl- phenyl)-piperidin-4-yl]-7-(2-trifluoromethyl-benzyl)-2,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-6-one and a mixture of excipients comprising one or more lipophilic excipient(s); one or more hydrophilic surfactant(s); and optionally one or more hydrophilic co-solvent(s). The invention further relates to a crystalline form of said compound, and its use for the preparation of the present compositions. The invention further relates to pharmaceutical uses of the compositions for the prevention / prophylaxis or treatment of diseases and disorders related to pathogenic events associated with elevated levels of C5a and/or with C5aR activation.
Patent EP-4102489-A1 (EP)
Inventor: FENG ZIKANG
IPC: G09F9/30
Filed: 2020-04-16
Abstract: The present invention provides a display device, including a flexible display assembly carried on a housing. The housing includes a first housing and a second housing. The second housing is provided with a winding assembly, a sliding assembly, and a pretension member. The present invention drives the sliding assembly to slide through a relative sliding of the first housing and the second housing. The winding assembly is used to reel in or pull out the flexible display assembly by sliding the sliding assembly, and the sliding assembly slides under driving of a pretension of a pretension member.
Patent EP-3908578-A1 (EP)
Inventor: AKABAYOV BARAK
IPC: A61K31/4965
Filed: 2020-01-08
Abstract: La présente invention concerne des compositions antibactériennes et des procédés d'utilisation de celles-ci, telles que dans le traitement de maladies infectieuses. L'invention concerne également un procédé de criblage de molécules permettant d'identifier des composés biologiquement actifs potentiels.
Patent EP-4182341-A1 (EP)
Title: Transposons et transposases hyperactifs
Inventor: SANDIG VOLKER
IPC: C12N9/12
Filed: 2020-07-17
Abstract: La présente invention concerne un polypeptide comprenant une transposase piggyBac ou un fragment ou un dérivé de celle-ci ayant une fonction transposase comprenant au moins une substitution d'acide aminé. En outre, la présente invention concerne un élément transposable comprenant une séquence de répétition gauche et une séquence de répétition interne gauche piggyBac ou de type piggyBac, la séquence de répétition interne gauche comprenant au moins une modification nucléotidique. En outre, la présente invention concerne un kit comprenant la transposase et/ou l'élément transposable ci-dessus. De plus, la présente invention concerne un système de ciblage comprenant la transposase et/ou l'élément transposable ci-dessus.
Patent EP-4017722-A1 (EP)
Title: Multilayer structure manufacturing method for bonding layers with adhesive film(s)
Inventor: CHOO YEOW CHUN RICKY
IPC: B32B15/18
Filed: 2020-07-28
Abstract: The invention relates to a multilayer structure manufacturing method comprising the following steps of bonding layers (4, 8, 5, 6) of its structure (1, 7) with thermosetting adhesive film(s) (2, 3), said thermosetting adhesive film(s) having recommended operating conditions of temperature and duration in its technical specification (TDS) to polymerize during thermal lamination (500, 600). The method is characterized in that said thermosetting adhesive is laminated with said layers in order to present a partial polymerization rate less than polymerization rate resulting from said recommended operating conditions.
Patent EP-3919488-A1 (EP)
Inventor: LI JIN
IPC: C07D407/14
Filed: 2020-01-21
Abstract: The present application discloses an immunomodulator, and specifically discloses a compound depicted by formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present application can bind effectively to STING and has a good agonistic action on STING protein, and exhibits a good inhibitory effect on multiple tumors. Thus, the compound provided in the present application serves as a STING agonist and can be used for treating various related conditions. The compound provided in the present invention shows a very promising prospect for application thereof in the preparation of a medicament for treating a disease associated with STING activity (in particular, a medicament for treating an inflammatory disease, an allergic disease, an autoimmune disease, an infectious disease, a cancer or a precancerous syndrome) and in the preparation of an immune adjuvant, providing a novel option for clinically screening and/or preparing drugs for diseases associated with STING activity.
Patent EP-3884012-A1 (EP)
Inventor: PENDRAY JOHN R
IPC: C10J3/06
Filed: 2020-01-27
Abstract: A method, system, and apparatus for decomposing a biomass feedstock include providing a layer of inert particulate matter, such as sand, to line and insulate the bottom surface of a main chamber of a reactor where pyrolysis and oxidation are conducted to produce char and producer gases as primary products. In an embodiment, feedstock positioned in a side region of the reaction chamber insulates side walls of the main chamber from heat in the center region of the main chamber. In an embodiment of the method, a rate of removal of solid products such as char from the reactor is controlled in response to a temperature detected at a position of an extraction tube inlet of the reactor. Activated charcoal may be obtained as a primary product using the system and method, by feeding oxygen into the reactor at an inlet positioned adjacent to an inlet to the extraction chamber.
Patent EP-4000106-A1 (EP)
Title: Led arrays
Inventor: WANG TAO
IPC: H01L33/08
Filed: 2020-07-14
Abstract: A method of producing a light emitting diode (LED) array comprises: forming a plurality of layers (100, 101, 103) of semiconductor material; forming a dielectric mask layer (104) over the plurality of layers, the dielectric mask layer having an array of holes (106) through it each exposing an area of one of the layers of semiconductor material, and growing an LED structure (110, 112, 114) in each of the holes arranged to emit light over a range of wavelengths. At least some of the plurality layers (101) form a distributed Bragg reflector (DBR) arranged to reflect light of at least some of said range of wavelengths.
Patent EP-3925995-A1 (EP)
Inventor: MOROIWA TETSUJI
IPC: C08J5/24
Filed: 2020-02-05
Abstract: The objective of the present invention is to provide a liquid composition which is for a fiber reinforced plastic intermediate base material, and which imparts excellent FRP mechanical properties and can suppress voids as much as possible. 
     The liquid composition for a fiber reinforced plastic intermediate base material according to the present invention is characterized by being obtained by mixing (A) and (B). (A): a composition including a compound (a) having at least two isocyanate groups, and (B): a composition which includes (b1) as an essential component and may include (b2) and (b3). 
(b1): a monoalcohol compound having an ethylenically unsaturated group, 
(b2): a compound having at least two reactive groups with isocyanate groups 
, and (b3): a polymerization inhibitor.
Patent EP-3923922-A1 (EP)
Inventor: OLSEN MARK JON
IPC: A61K31/381
Filed: 2020-02-14
Abstract: Isotopically-stabilized tetronimide compounds comprising one or more deuterium atoms, derivatives, and intermediates, thereof, including methods for their synthesis, pharmaceutical compositions thereof, and methods of using these compounds to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are disclosed. One aspect relates to molecules that modulate the expression or catalytic activity of aspartyl (asparaginyl) β-hydroxylase (ASPH) within or on the surface of a cell. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases. Related aspects include uses of the compounds to modulate the activity of viruses, as anti¬ hyperlipidemia agents, and as agents to ameliorate or treat thrombosis and related cardiovascular and metabolic disorders.
Patent EP-4022312-A1 (EP)
Title: Procédé d'isolement de nucléosomes circulants
Inventor: ECCLESTON MARK EDWARD
IPC: C12Q1/6886
Filed: 2020-08-27
Abstract: L'invention concerne des procédés de séparation de nucléosomes acellulaires circulants comprenant de l'ADN lieur présents dans un échantillon de liquide biologique, en particulier des nucléosomes d'origine pathologique. De tels procédés permettent une analyse améliorée de marqueurs génétiques et épigénétiques associés à des nucléosomes d'origine pathologique.
Patent EP-4035251-A1 (EP)
Inventor: HALL JAMES
IPC: H02N2/18
Filed: 2020-08-17
Abstract: A controller associated with an engine monitoring system may determine a voltage value concerning at least one supercapacitor associated with the engine monitoring system. The controller may selectively cause, based on determining whether the voltage value satisfies a voltage value threshold, the at least one supercapacitor, or a battery associated with the engine monitoring system, to provide electrical power to a sensor system associated with the engine monitoring system. The controller may obtain, from the sensor system, vibration information relating to an engine associated with the engine monitoring system and pressure information relating to a crankcase of the engine. The controller may determine, based on the vibration information and the pressure information, engine speed information related to the engine and may send the engine speed information to a monitoring device.
Patent EP-4018756-A1 (EP)
Inventor: ELLIOT MICHAEL
IPC: H04W72/12
Filed: 2020-08-19
Abstract: L'invention concerne un procédé de gestion d'un certain nombre de flux de données sans fil actifs dans un dispositif. Une bande de fonctionnement du dispositif est détectée, le dispositif étant susceptible de prendre en charge simultanément des communications Wi-Fi et Bluetooth par partage du temps de la bande de fonctionnement entre les communications Wi-Fi et Bluetooth. Une requête de fonctionnement simultané dans au moins deux modes parmi un mode de communication Wi-Fi, un mode de communication de source Bluetooth, ou un mode de communication de récepteur Bluetooth est détectée. En réponse à la détection de la requête, seuls deux modes parmi le mode de communication Wi-Fi, le mode de communication de source Bluetooth ou le mode de communication de récepteur Bluetooth sont sélectionnés.
Patent EP-4022568-A1 (EP)
Inventor: CHUNDI CHARISHMA
IPC: H04N21/44
Filed: 2020-08-19
Abstract: L'invention concerne des systèmes et des procédés pour afficher des sujets d'une partie de contenu et rechercher un contenu associé à un sujet particulier dans le contenu. Des données multimédias d'un contenu sont analysées durant la lecture ,et un certain nombre de signatures d'action sont identifiées. Chaque signature d'action est associée à un sujet particulier dans le contenu. Les signatures d'action sont stockées, conjointement avec une estampille temporelle correspondant à une position de lecture à laquelle la signature d'action commence, en association avec un identifiant du sujet particulier. Lors de la réception d'une commande, des icônes représentant chaque signature d'action d'un certain nombre de signatures d'action à la position de lecture actuelle ou à proximité de celle-ci sont affichées. Lors de la réception d'une sélection, par l'utilisateur, d'une icône correspondant à une signature particulière, une partie du contenu correspondant à la signature d'action est lue ou un contenu associé à la signature représentée par l'icône sélectionnée est recherché.
Patent EP-4034176-A1 (EP)
Title: Antagoniste grpr radiomarqué pour l'utilisation comme agent théragnostique
Inventor: MARIANI MAURIZIO F
IPC: A61K103/00
Filed: 2020-09-23
Abstract: La présente invention concerne des agents pharmaceutiques ciblant le récepteur peptidique libérant de la gastrine (GRPR) et leur utilisation dans une approche théragnostique pour la sélection et la thérapie de sujets atteints de malignité exprimant GRPR. En particulier, la présente invention concerne une composition pharmaceutique d'un antagoniste GRPR radiomarqué, pour l'utilisation dans le traitement de tumeurs positives au GRPR chez un sujet humain sélectionné pour ledit traitement, ledit sujet ayant été sélectionné pour le traitement par imagerie PET/CT ou PET/MRI avec un antagoniste marqué Ga68 correspondant comme agent de contraste.
Patent EP-4032328-A1 (EP)
Title: Printing substrate, method of manufacture, method of use, and computer system
Inventor: GEORGIOU THANASIS
IPC: B41J15/00
Filed: 2020-09-16
Abstract: A receipt roll for a receipt printer of a point of sale system, the receipt roll comprising a substrate for the printing of receipt information by the receipt printer, and at least one near field RF communicator carried by the substrate and configured to store a unique identifier for communicating via near field communications to a near field communication device in near field range.
Patent EP-4037774-A1 (EP)
Inventor: ASNAFI VAHID
IPC: A61K39/395
Filed: 2020-10-01
Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive proliferation of mature activated CD4+ T cells associated with the human T-cell lymphotropic virus type I (HTLV-I). The inventors performed an integrated genomic analysis of a retrospective cohort of 62 ATL patients mainly originating from Africa and the Caribbean area. In particular, they identified a subset of mutations in the TCR/NF-KB pathway (PLCG1, CARD11, PRKCB, CBLB, IRF4, CSNK1A1, FYN, RHOA, VAV1). Furthermore, the inventors investigated the effects of an anti-CD3 antibody (OKT3) exposure on 4 ATL samples including 2 cases harboring CARD 11 and PRKCB gain of function alterations and 2 cases without any TCR pathway mutation. The data suggest that ATL harboring TCR pathway mutations clearly responded to anti-CD3 (Fig. IB, red + OKT3) and died by apoptosis possibly by a mechanism resembling AICD. Importantly, these TCR-pathway/NFKB mutated patients also showed poorer outcome as compared to unmutated cases. Accordingly, the present invention relates to a method of treating adult T-cell leukemia/lymphoma (ATL) in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an anti-CD3 antibody.
Patent EP-3946455-A1 (EP)
Inventor: TOMASEVIC NENAD
IPC: A61P19/02
Filed: 2020-03-26
Abstract: The present disclosure relates to methods of treating diseases or disorders associated with LGL and/or NK cells, methods of reducing or depleting LGL and/or NK cells, and methods of inducing ADCC activity using antibodies that bind to a cell surface protein on LGL and/or NK cells and comprise enhanced ADCC activity. The present invention also relates to a method of depleting or reducing the numbers of large granular lymphocytes and natural killer cells in a human subject upon administration of CD94 or CD57 or NKG2A binding molecule that consists of a part that specifically binds to the CD94 or CD57 or NKG2A receptors and an immunoglobulin Fc part. In a specific embodiment, a method of the invention depletes or reduces the number of large granular lymphocytes and natural killer cells in spleen, blood, bone marrow, joints, or other tissues.
Patent EP-4034748-A1 (EP)
Inventor: ALJINDAN JANA MOHAMMED
IPC: E21B43/12
Filed: 2020-09-23
Abstract: Selon l'invention, une chambre à vide (104) est évacuée par une pompe à vide (102). La chambre à vide est positionnée à l'intérieur d'un puits de forage. Un puits de forage est exposé de manière fluidique à l'intérieur de la chambre à vide après que la chambre à vide a été évacuée. Au moins une partie du condensat à l'intérieur du puits de forage est détendue en réponse à l'exposition fluidique d'un puits de forage à l'intérieur de la chambre à vide.
Patent EP-3958878-A1 (EP)
Title: Conditioning methods for gene therapy
Inventor: BOITANO ANTHONY
IPC: A61P7/00
Filed: 2020-04-24
Abstract: The disclosure provides compositions and methods useful for the depletion of a specific population of endogenous hematopoietic stem cells and/or immune cells from a subject prior to transplantation with genetically modified stem cells to improve the engraftment of the transplanted stem cells and provide gene therapy. The disclosure provides compositions and methods for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ or CD45+ cells in a patient, such as a human.
Patent EP-3962540-A1 (EP)
Inventor: YOUNG SCOTT
IPC: C12N15/53
Filed: 2020-04-21
Abstract: The invention relates generally to peptide biomarkers with specific ionization characteristics to directly quantify one or more target HPPD proteins in biological samples, including crop plant samples, by liquid chromatography coupled tandem mass spectrometry multiple reaction monitoring (MRM). The peptide biomarkers in combination with MRM-based methods may be used to quantify a single target protein or multiple target proteins within a crop plant, such as maize, utilizing selected peptide biomarkers either alone or in combination. The present disclosure allows for broad based, reliable quantitation in different biological matrices, including plant matrices. Also provided are different peptide biomarker combinations that can be used to perform the methods of the invention.
Patent EP-4066299-A1 (EP)
Inventor: HÖLLER STEFAN
IPC: C25B9/23
Filed: 2020-11-04
Abstract: The invention relates to a sealing arrangement which is provided for an electrochemical cell and comprises a metal plate (7) and a seal (18, 19) that is located thereon and that forms at least one closed sealing ring located on the plate (7). According to the invention, a circumferential inner support structure (20, 22) supporting the seal (18, 19) inwardly is formed and an outer support structure (21, 23) supporting the seal (18, 19) outwardly is formed, said support structures being made of sintered metal and being integrally bonded to the plate (7).
Patent EP-4055516-A1 (EP)
Title: Fonctionnalité de repérage pour émergence
Inventor: SCHIKORA MAREK PIOTR
IPC: G06K9/00
Filed: 2020-11-06
Abstract: Afin d'améliorer la discrimination précoce des stades d'émergence de plantes, une application d'émergence précoce selon l'invention est proposée sur la base d'un réseau de neurones artificiels éventuellement avec des mécanismes « d'attention », qui détectent le nombre de plantes qui se sont ouvertes après le semis et qui sont présentes dans le champ. De cette manière, l'agriculteur peut facilement déterminer si des cibles de densité de culture sont satisfaites à un stade précoce après le semis et facultativement recevoir des recommandations sur une culture dérobée.
Patent EP-3966912-A1 (EP)
Inventor: SHERSTYUK MYKOLA
IPC: H02J7/00
Filed: 2020-05-08
Abstract: Disclosed are methods, systems, and devices to adaptively charge a battery. Charging current is applied to charge the battery. After application of the charging current, at least one discharging pulse is applied to the battery, and in response to application of the at least one discharging pulse, a first value and a second value of a relaxation voltage of the battery is determined. The first value corresponds to a maximum value of the relaxation voltage, and the second value corresponds to a value of the relaxation voltage determined after a particular wait period following the application of the at least one discharging pulse. Based on a difference between the first value and the second value of the relaxation voltage, one or more charging parameters are adapted, and the battery is charged based on the adapted one or more charging parameters.
Patent EP-4058488-A1 (EP)
Inventor: AUDENAERT FRANS A
IPC: C08F214/22
Filed: 2020-11-06
Abstract: Described herein is method of functionalizing fluorinated polymers, wherein a reaction compound is grafted onto a fluorinated polymer, wherein the fluorinated polymer comprises at least one Br, I, and Cl group and is free of -CH 2 CH 2 - linkages. In one embodiment, the functionalized fluorinated polymer comprises a perfluorinated polymer backbone with pendent groups therefrom is disclosed, wherein at least one pendent group is according to formula I: where Rf is a bond, or a divalent perfluorinated group, optionally comprising at least one in-chain ether linkage; Z is I, Br, or C1; and X comprises a functional group selected from the group consisting of an alcohol; phosphorous acid and salts thereof; phosphoric acid and salts thereof; a silane; an amine; an amide; a hydrocarbon, optionally comprising an in-chain oxygen, nitrogen, or sulfur linkage; a carboxylic acid and salts thereof; an ester; a sulfonyl fluoride, a sulfonic acid and salts thereof; and combinations thereof. Such functionalized fluorinated polymers may be used in coating compositions.
Patent EP-4065269-A1 (EP)
Title: Alumina having a particular pore profile
Inventor: HERNANDEZ JULIEN
IPC: B01J23/10
Filed: 2020-11-25
Abstract: The present invention relates to an alumina having a particular pore profile and good thermal stability. This alumina is also characterised by the fact that it has a high apparent density. The alumina has, after calcination in air at 1100°C for 5 hours: - a pore volume, in the pore size range of between 5 nm and 100 nm, that is between 0.50 and 0.75 ml/g, more particularly between 0.50 and 0.70 ml/g; and - a pore volume, in the pore size range of between 100 nm and 1000 nm, that is less than or equal to 0.20 ml/g, more particularly less than or equal to 0.15 ml/g, or even less than or equal to 0.10 ml/g.
Patent EP-4077651-A1 (EP)
Inventor: DE VLEESSCHAUWER DAVID
IPC: C12N9/22
Filed: 2020-11-30
Abstract: It was now found that the expression of a nucleotide sequence as described in the method of the invention in a plant cell results in much higher rates of indels compared to those seen in cells transformed with a control nucleic acid molecule. Thus, the invention is directed to codon-optimized Cas9 endonuclease-encoding polynucleotide. Accordingly, the present invention provides a method for modifying a target site in the genome of a plant cell, the method comprising providing one or more guide RNA and a Cas endonuclease to said plant cell, wherein said guide RNA and Cas endonuclease are capable of forming a complex that enables the Cas endonuclease to introduce a double strand break at said target site, and wherein the Cas9 endonuclease is expressed in the plant cell from a polynucleotide comprising an codon-optimized Cas9 endonuclease encoding nucleic acid molecule with a nucleotide sequence selected from the disclosed nucleotide sequences.
Patent EP-4051630-A1 (EP)
Inventor: BOUKARI MOROU
IPC: C01B3/08
Filed: 2020-10-28
Abstract: The invention relates to a method for producing a hydrogen-generating fuel, the hydrogen-generating fuel obtained, a method for producing hydrogen from the fuel, a device for carrying out the production method, a method for operating the device, and a hydrogen-based fuel obtained by means of the production method. The production method is characterised in that it consists in mixing, in a liquid, particles of one or more metals which are corrodible by a basic chemical substance or an acidic chemical substance for the purpose of producing hydrogen, the particles being kept in suspension in the liquid, and the mixture composed of the liquid and the particles being chemically stabilised so as to prevent chemical reaction between the liquid and the particles.