Patent SG-11201806863W-A (SG)
Title: Tetracyclic pyridone compounds as antivirals
Inventor: FU JIPING
IPC: C07D491/14
Filed: 2017-02-16
Abstract: WO 17 / 1408 21 Al ( I ) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/140821 Al 24 August 2017 (24.08.2017) WIPO I PCT 11111111111111011101111111111101011111011101011111111111101011101111111110111111 International Patent Classification: Joseph Michael; c/o Novartis Institutes for BioMedical C07D 217/08 (2006.01) A61K 31/4745 (2006.01) Research Inc., 5300 Chiron Way, Emeryville, California C07D 491/14 (2006.01) A61P 31/12 (2006.01) 94608 (US). (51) (21) International Application Number: PCT/EP2017/053568 (22) International Filing Date: 16 February 2017 (16.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/297,590 19 February 2016 (19.02.2016) US 62/434,658 15 December 2016 (15.12.2016) US (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). (72) Inventors: FU, Jiping; c/o Novartis Institutes for BioMed- ical Research Inc., 5300 Chiron Way, Emeryville, Califor- nia 94608 (US). JIN, Xianming; c/o Novartis Institutes for BioMedical Research Inc., 5300 Chiron Way, Emeryville, California 94608 (US). LEE, Patrick; c/o Novartis Insti- tutes for BioMedical Research Inc., 5300 Chiron Way, Emeryville, California 94608 (US). LU, Peichao; c/o No- vartis Institutes for BioMedical Research Inc., 5300 Chiron Way, Emeryville, California 94608 (US). YOUNG, (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS (57) : The invention provides com- pounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharma- ceutical compositions containing such com- pounds, and methods to use these compounds, salts and compositions for treating viral infec- tions, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV. WO 2017/140821 Al IMM011111 11111111010130101101111 IIII110ENUMIE Declarations under Rule 4.17: Published: as to applicant's entitlement to apply for and be granted — with international search report (Art. 21(3)) a patent (Rule 4.1700)