baber/WOPTO huggingface dataset:
Patent EA-019115-B1 (EA)
Title: Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
Inventor: MOLINO BRUCE F
IPC: A61K31/55
Filed: 2006-07-17
Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II) where the carbon atom designated * is in the R or S configuration, and the substituents X and R-Rare as defined herein.
Patent EA-014099-B1 (EA)
Title: Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides
Inventor: DIETZ JOCHEN
IPC: A01N35/04
Filed: 2006-08-01
Abstract: The invention relates to fungicidal mixtures containing the following as active components: 1) at least one 1-methyl pyrazol-4-yl carboxylic acid anilide of formula (I),in which X = O or S, R= C-Chaloalkyl, R= hydrogen, R, Rand R= independently of one halogen or C-C-alkyl; and 2) at least one active ingredient II, selected from the active ingredient groups A) to F): A) azoles; B) strobilurins; C) carboxamides; D) heterocyclic compounds; E) carbamates; F) other fungicides; in a synergistically active quantity. The invention also relates to a method for controlling pathogenic fungi using mixtures of at least one compound I and at least one active ingredient II, to the use of the compound(s) I and active ingredients II for producing mixtures of this type and to agents and seeds containing said mixtures.
Patent EA-014251-B1 (EA)
Title: A process for producing light olefins from an oxygenate-containing feedstock
Inventor: SENETAR JOHN J
IPC: C07C2/00
Filed: 2006-12-18
Abstract: Improved processing of an oxygenate-containing feedstock involving increased or enhanced removal or recovery of carbonyls, particularly, acetaldehyde via either or both application of a more stringent stripping regime or addition of a sulfite-containing material.
Patent EA-015278-B1 (EA)
Title: Oral care implement
Inventor: HOHLBEIN DOUGLAS J
IPC: A46B9/04
Filed: 2005-12-21
Abstract: An oral care implement with a handle includes a head with a tissue cleanser. The tissue cleanser may be a pad composed of an elastomeric material. The pad is disposed on the head on a surface opposite the tooth cleaning elements. The tissue cleanser may include a plurality of nubs extending for cleaning between the papillae of the tongue. The tissue cleanser may include a plurality of conically shaped nubs. A tissue cleanser can be used to reduce oral malodor problems and remove oral epithelial cells.
Patent EA-013486-B1 (EA)
Title: Hydraulic machine, in particular hydraulic motor, and metering device comprising such a motor
Inventor: DARBOIS MATTHIEU
IPC: F04B43/02
Filed: 2006-12-07
Abstract: Hydraulic machine, in particular hydraulic motor, comprising a casing (2) with a body (3) and a cover (4); a separation means (M) which can make a reciprocating movement and defines two chambers (5, 6); hydraulic switching means (C) comprising a distribution member (D); a compartment (13) in the body of the casing connected to a pressurized-liquid inlet (14), and initiating means (15) comprising a pusher (A) connected to the separation means, these initiating means being able, at the end of the stroke, to cause a sudden change in the position of the switching means, under the action of an elastic means (E), in order to reverse the stroke. The distribution member (D) comprises a distribution slide valve (16) applied against a flat plate (17) which is fixed relative to the body of the casing, the slide valve being able to slide in a fluid-type manner, without a seal, against the plate (17), which has orifices connected respectively to the chambers (5, 6) of the casing and to a liquid outlet orifice (18), the slide valve (16) being intended, depending on its position, to close some of the orifices or to place them in communication with the fluid inlet or the outlet.
Patent EA-014778-B1 (EA)
Title: Combination therapy of hiv treatment
Inventor: ZHANG HONG
IPC: A61K31/7072
Filed: 2007-05-04
Abstract: Co-administration of alovudine and zidovudine at ratios considerably in excess of the prior art completely or substantially abolishes the mitochondrial toxicity of alovudine in mitochondrial DNA depletion experiments. The invention thus provides pharmaceutical compositions comprising alovudine and zidovudine in a molar ratio in the range 1:100 to 1:350 and methods for the treatment or prophylaxis of multiply resistant HIV comprising the simultaneous or consequential administration of alovudine and zidovudine in the characteristic molar ratio.
Patent EA-016953-B1 (EA)
Title: Tranformable cushioned furniture and cushiony element therefor
Inventor: AVTONOMOV OLEG VIKTOROVICH
IPC: A47C17/13
Filed: 2010-07-13
Abstract: A transformable cushioned furniture, in particular sofa bed comprises a rigid carcass and cushiony elements arranged on corresponding carcass parts, wherein the rigid carcass comprises an adjustable frame and guiding means for changing a position of a cushiony element resting on the frame when transforming the adjustable frame from an unfolded position to a folded one. According to the invention the cushiony element resting on the frame is made as a one-piece mattress from an elastic material covering substantially all the surface of the adjustable frame in its unfolded position and the guiding means are adapted to put a part of the mattress under the adjustable frame when transforming thereof into the folded position so that in the folded position the mattress has a substantially U-shaped configuration. The invention allows to form a homogenous plain sleeping berth of adequate softness without joints in zones of connections of the adjustable frame keeping easiness and transformation convenience.
Patent EA-020895-B1 (EA)
Title: Collapsible cycle
Inventor: RYAN GRANT JAMES
IPC: B62M1/36
Filed: 2009-07-17
Abstract: A collapsible cycle (1) for use by a rider (11) over a terrain surface (36). The cycle (1) includes a frame (2) having front (3) and rear (4) portions; a seat (13) attached to the frame; a steering member (7); a front wheel (5) rotatable about a primary axis (17) and attached to a steering member (7); said steering member (7) being attached to the front (2) frame (3) portion for rotation about a secondary axis (18) orthogonal to said primary axis (17); a steering mechanism (8) coupled to the steering member (7); a rear wheel (6), rotatably attached to the rear frame portion (4) for rotation in third plane about a tertiary axis (19); the front and rear wheels are of different diameters, a drive mechanism (38) operatively coupled to the front (5) and/or rear (6) wheel; wherein said cycle being collapsible from an erect riding configuration to a collapsed configuration by moving said wheels (5, 6) into mutually closer proximity, wherein said cycle has with a recess or aperture (39) in one wheel capable of at least partially accepting the insertion of the other wheel and a pair of handlebars (9) of said steering mechanism (8) being positioned below and/or behind said seat (13).
Patent EA-021105-B1 (EA)
Title: Working element to remove snow and ice slippery coat from surface of roads and aerodromes
Inventor: GANZHA VLADIMIR ALEXANDROVICH
IPC: E01H5/12
Filed: 2012-05-25
Abstract: The invention relates to machines for removing snow and ice slippery coat from surface of roads and aerodromes in winter time, in particular, to a working member therefor. The working element comprises a frame, where levers are fixed hingedly with the possibility of rotation in the vertical plane and carry axes on free ends in the plan like a wedge, every of which is installed on the axis with the possibility with cutting discs with a continuous single-sided wedge rim arranged as freely rotating around it and at the angle α to the longitudinal axis of the working element, with a larger base outside, two front cutting discs are installed on the common lever and face each other with their larger bases with an angle β between them and a distance h between cutting edges in the place of their convergence. The frame equipped with two royal wheels in its rear part is installed capable of rotation in the vertical plane. The working member also comprises a hydraulic system comprising a hydraulic reservoir, a pump connected to 3-positioned, 4-linear hydraulic distributor, providing communication of the pump in one of positions with a pressure regulator, and in another position with a hydraulic accumulator, a pressure gage and blind cavities of one-way hydraulic cylinders connected to the frame and a corresponding lever. The technical effect provides to reduce energy intensity and to increase efficiency of a process of mechanical destruction of strong ice and snow slippery coat.
Patent EA-020526-B1 (EA)
Title: N-4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer
Inventor: PAYTON MARC
IPC: A61P35/02
Filed: 2010-09-09
Abstract: The present invention relates to methods of using the compound, N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine or a pharmaceutically acceptable salt thereof, to treat cancers, including solid tumors, which have become resistant to treatment with chemotherapeutic agents, including anti-mitotic agents such as taxanes, and/or other anti-cancer agents, including aurora kinase inhibiting agents. The invention also includes methods of treating cancers refractory to such treatments by administering a pharmaceutical composition, comprising the compound to a cancer subject.
Patent EA-024082-B1 (EA)
Title: Sporting activity surface using structural modules
Inventor: CULLETON PAUL DAVID
IPC: E01C13/02
Filed: 2010-07-13
Abstract: An area suitable for sporting activities comprising an upper synthetic surface layer and a sub-surface support layer which includes a load bearing structural module, wherein the structural module comprises a top wall and a bottom wall spaced therefrom by one or more supporting elements so as to define a volume between the top and bottom walls, the top wall being provided with a plurality of apertures to permit the flow of liquid into and out of the volume, and the size and shape of the apertures of the top wall being such that the apertures cause substantially no variation in the flatness of the synthetic surface layer, the bottom wall being provided with a plurality of apertures which are larger than those in the top wall, and the size and shape of the apertures of the bottom wall being such that a sphere with a diameter which exceeds the maximum diameter allowable for spheres to be able to pass through the apertures in the top wall, may be able to pass through the apertures in the bottom wall.
Patent EA-024164-B1 (EA)
Title: Pharmaceutical composition
Inventor: SOBKO YURII ANATOLIIOVYCH
IPC: A61P31/04
Filed: 2013-09-26
Abstract: The invention relates to the filed of veterinary medicine, in particular, to preparations for treating bacterial infections in livestock, i.a. poultry. A pharmaceutical composition comprises the active antibacterial substances: fluoroquinolone or pharmaceutically acceptable salts thereof; trimethoprim, antibiotic of polymyxin group, or pharmaceutically acceptable salts thereof; adjuvants (preservatives, stabilizers, organic acids, water), and can further comprise functional additives: feeding indicators (food grade dyes) or sweeteners, with the following component ratio, wt.%: fluoroquinolone - 0.5-15.0, trimethoprim - 0.5-15.0, polymyxin - 0.5-15.0, preservative - 1.0-5.0, stabilizer - 0.1-5.0, organic acid - 5.0-35.0, functional additive - 0.01-5.0, water - the rest.
Patent EA-024746-B1 (EA)
Title: Apoptosis signal-regulating kinase inhibitor
Inventor: NOTTE GREGORY
IPC: C07D401/14
Filed: 2013-01-24
Abstract: The present invention relates to a compound of formula (I)The compound has apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.
Patent EA-030582-B1 (EA)
Title: Composition and methods of forming a surface and construction material
Inventor: FRIEDMAN ROBERT D
IPC: E02D3/11
Filed: 2013-02-28
Abstract: The claimed group of inventions provides methods and a composition for the installation and formation of roads and construction materials. One aspect provides a method of forming a traversable surface comprising the following steps: obtaining a soil stabilizing agent comprising a polystyrene acrylate copolymer, obtaining a base material, and obtaining a polymer solvent; combining the soil stabilizing agent, base material, and solvent to form a mixture; and compacting the mixture to form a traversable surface. Another aspect provides a method of forming a construction material. Yet another aspect provides a composition for forming a traversable surface or construction material comprising a soil stabilizing agent, a base material, and a polymer solvent; or a cured soil stabilizing agent and a base material; wherein the soil stabilizing agent comprises a polystyrene acrylate copolymer; and the soil stabilizing agent and base material are uniformly mixed throughout the composition. The use of base materials and stabilizing agents provides affordable roads and construction materials.
Patent EA-028938-B1 (EA)
Title: Temperature swing adsorption system and method for purifying fluids using the same
Inventor: DOONG SHAIN-JER
IPC: B01D53/047
Filed: 2014-04-23
Abstract: A temperature swing adsorption system includes a first adsorption bed configured to receive a feed stream and adsorb a contaminant from the feed stream to produce a product stream; a second adsorption bed configured to receive a portion of the product stream and a cooling stream to reduce a temperature of the second adsorption bed; a third adsorption bed configured to receive the heated product stream to increase a temperature of the third adsorption bed; a separation system to separate the cooled product stream into a first component stream and a second component stream; and a fourth adsorption bed configured to receive the first component stream and to enrich an adsorptive concentration of the first component stream. The enriched first component stream is directed to the second adsorption bed to provide the cooling stream.
Patent EA-031315-B1 (EA)
Title: Movable hydrofoil vessel control system
Inventor: PIVEC SIMON
IPC: B63B1/30
Filed: 2014-08-14
Abstract: A movable hydrofoil vessel control system that can be installed in a vessel having at least two pairs of hydrofoils (4a and 4b), a hull (13), seats (14) and a rudder (16), the system comprising a lever plate (5) mounted in the bottom part (15) of the inside vessel space and having a Bowden cable (7) secured thereto and able to connect said lever plate (5) to an engine (6) to provide a combined vessel steering mode by means of the engine (6) and hydrofoils (4a, 4b); a front lever disk (9a) connected to said lever plate (5) by means of a lever (10c); a connection shaft (8) connecting said front lever disk (9a) and a back lever disk (9b) to provide the possibility of rotation of said front and back lever disks (9a, 9b) in opposite directions; front levers (10a) and back levers (10b) fastened on two sides to said front lever disk (9a) and back lever disk (9b), respectively, and connecting said front and back lever disks (9a, 9b) to hydrofoils (4a, 4b); and a device (1) for lifting the airfoils (4a, 4b) mounted on the front shaft (2a) and on the back shaft (2b) including a motor (1b) for rotation of the hydrofoils (4a, 4b); an automatic brake (1c) for holding the hydrofoils (4a, 4b) in the preset position; and a sensor (1d) for detecting a change in the position of the hydrofoils (4a, 4b), the lifting device (1) being able, with the aid of the sensor (1d), to release the brake (1c) in case of an impact of the hydrofoils (4a, 4b) against an obstacle, and to turn the hydrofoils (4a, 4b) back so that the hydrofoils (4a, 4b) lift above the vessel hull (13) or from water, and to return the hydrofoils (4a, 4b) to the preset position as they are stabilized after the impact.
Patent EA-031889-B1 (EA)
Inventor: HUANG JUN
IPC: C07H17/08
Filed: 2015-03-10
Abstract: Изобретение относится к области макролидных соединений и их применению в сельском и лесном хозяйстве. Предложены смесь тенвермектина A и тенвермектина B для предупреждения распространения и контроля численности насекомых-вредителей и клещей в сельском и лесном хозяйстве, причем структурная формула тенвермектина представляет собойгде R является CHили CH, и если R является CH, указанное соединение является тенвермектином A, а если R является CH, указанное соединение является тенвермектином B, причем массовое соотношение между тенвермектином A и тенвермектином B равно 1:9, и применение указанной смеси при получении препаратов для предупреждения и контроля численности насекомых-вредителей или клещей в сельском и лесном хозяйстве.
Patent EA-032075-B1 (EA)
Title: Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
Inventor: BELLENIE BENJAMIN RICHARD
IPC: C07D417/14
Filed: 2014-04-24
Abstract: The present invention provides compounds of formula (I)which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
Patent EA-036405-B1 (EA)
Title: Method for determining probability of presence of unstable atherosclerotic plaques in coronary arteries in patients with coronary atherosclerosis
Inventor: Polonskaya Yana Vladimirovna
IPC: G01N33/50
Filed: 2018-05-04
Abstract: The invention relates to the field of medicine, namely to cardiology. The provided method consists in determining the values of inflammatory biomarkers in the blood serum of a patient with coronary atherosclerosis: C-reactive protein, interleukin-6, interleukin-8, monocyte chemoattractant protein-1 and an oxidative biomarker - a FORT test, the obtained values are compared with the threshold value of the corresponding biomarker: for a C-reactive protein, a value of 10 mcg/ml, for interleukin-6, a value of 10 pg/ml, for interleukin-8, a value of 12 pg/ml, for monocyte chemoattractant protein-1, a value of 480 pg/ml, for the FORT test, a value of 2.3 mmol/l, and if there are at least four biomarker values greater than the threshold value of the corresponding biomarker, there is a probability of the presence of unstable plaques in the coronary arteries in a patient with coronary atherosclerosis. This method will allow to determine at an early stage the possibility of development of complications of IHD, to accelerate the pace of additional examination and choice of tactics for treatment of a patient.
Patent EA-035036-B1 (EA)
Title: Pyrazolo[1,5-a]pyrazin-4-yl derivatives as janus kinase (jak) inhibitors
Inventor: BROWN MATTHEW FRANK
IPC: A61P37/02
Filed: 2017-02-10
Abstract: Provided is a compound having the structure (I)or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A' and A" are independently O, C=O, C-R' or N-R", where R' and R" may independently be H, amino, -NRCOR, COR, -CONRR, C-Calkyl, or hydroxy(C-Calkyl), and R" may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A' and A" is O or C=O; Rand R are independently H, Br, Cl, F, or C-Calkyl; Ris H, C-Calkyl, or hydroxy(C-Calkyl); Ris selected from the group consisting of H, C-Calkyl, C-Calkoxy, hydroxy(C-Calkyl), phenyl(C-Calkyl), formyl, heteroaryl, heterocyclyl, -COR, -OCOR, -COOR, -NRCOR, -CONRR, and -(CH)-W, where W is cyano, hydroxy, C-Ccycloalkyl, -SONRR, and -SO-R, where Ris C-Calkyl, C-Ccycloalkyl, heteroaryl, or heterocyclyl; wherein each of said alkyl, cycloalkyl, heterocyclyl, or heteroaryl may be unsubstituted or substituted by halo, cyano, hydroxy, or C-Calkyl; X is C-Ror N, where Rmay be H or C-Calkyl; Rand Rare independently H, amino, C-Calkyl, or hydroxy(C-Calkyl); R, Rand Rare each independently H, C-Calkyl, C-Calkoxy(C-Calkyl), or C-Ccycloalkyl, where said C-Calkyl is optionally substituted by halo, CN or hydroxy; or Rand Rtogether with the atom bonded thereto form a 5- or 6-membered ring, said ring being optionally substituted by halo, hydroxy, CN, or C-Calkyl; and n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.
Patent ES-2165304-B1 (ES)
Title: Eje direccional para acoplamiento de motorruedas en vehiculos.
Inventor: RUIZ ARANA ALFONSO
IPC: B60K17/30
Filed: 2000-02-14
Granted: 2003-05-16
Abstract: Eje direccional para acoplamiento de motorruedas en vehículos. Tiene especial aplicación en vehículos de carga tales como tractores, dumpers, maquinaria agrícola, carretillas, etc. El eje direccional (1) incluye a sus extremos sendas bridas (4) en forma de "U". Las ramas (5, 6) tienen sendos orificios alineados (8, 9) y su eje geométrico (18) es común al que pasa por los semiejes definidos en las zonas extremas de unas extensiones (14, 15) previstas en una rótula (10) a la que queda anclado el motorreductor (3) de giro de la rueda correspondiente. La rótula (10) tiene un brazo lateral (19) conectado al cilindro de dirección (21). El eje geométrico (18) se resuelve superiormente mediante un cuello cilíndrico (16) abierto al interior de la rótula (10), pasante por el orificio (8) de la brida, interponiendo un rodamiento (22). Con esta disposición, por el vaciado axial del cuello cilíndrico (16) de la rótula (10), pueden pasar los latiguillos y otros conductos de acceso al motorreductor y sistema de freno de las ruedas (2), sin sufrir roces ni torceduras que hicieran prematuro su desgaste.
Patent ES-2206056-B1 (ES)
Title: Heat generation by two-stage biomass combustion comprises partial oxidation in gasification reactor for gas burning without intermediate energy generation
Inventor: GONZALO CALLEJO ALBERTO IGNACI
IPC: C10L5/40
Filed: 2002-10-25
Granted: 2005-04-16
Abstract: Heat generation by two-stage biomass combustion comprises partial oxidation to separate combustible gas from a carbonaceous residue, in a gasification reactor. The gas is then burned in a boiler for useful heat generation, without formation of intermediate energy.
Patent ES-2238891-B1 (ES)
Title: Procedimiento para tratar la superficie total de un cuerpo transparente difusor de luz utilizado en aparatos para visualizar mediante luz soportes fotograficos y/o de representacion.
Inventor: ALBA LUQUE DAVID
IPC: B24B1/00
Filed: 2003-01-15
Granted: 2006-11-16
Abstract: Procedimiento para tratar la superficie total de un cuerpo difusor transparente de luz utilizado en aparatos para visualizar mediante luz soportes fotográficos y/o de representación; que comprende: utilizar una plancha de metacrilato y cortar mediante sierra una porción, preferentemente regular; lijar en el sentido perimetral las caras laterales y pulir las mismas hasta conseguir superficies transparentes; cubrir dos caras laterales paralelas con una lámina adhesiva opaca de modo que cuando incide sobre ellas un haz luminoso perpendicular, paralelo a otras dos caras laterales sin cubrir, la luz se refleja hacia el interior de la porción de metacrilato; las caras mayores, frontal y posterior de la porción de metacrilato se tratan mediante esmerilado con muela abrasiva que gira a una velocidad de 1.400 revoluciones por minuto efectuándose la operación simultáneamente en las dos direcciones correspondientes a las propias de la superficie de la cara.