baber/WOPTO huggingface dataset:
Patent DE-69033083-T2 (DE)
Inventor: OKARMA THOMAS B
IPC: A61K35/17
Filed: 1990-06-28
Granted: 1999-08-26
Abstract: A method of stabilizing and sterilizing a device for the capture and recovery of cells is provided. The device consists of a biologically active substance immobilized on a polymeric surface.
Patent DE-69110133-T2 (DE)
Inventor: HUNG MIEN-CHIE
IPC: C07K14/00
Filed: 1991-10-16
Granted: 1996-02-15
Abstract: A novel TNF-preparation with high cytolytic activity is disclosed. The TNF preparation includes modified forms of tumor necrosis factor associated with the surface of liposomes of small diameter (between 0.02-0.05  mu m) known as SUV's. The tumor necrosis factor molecule is modified at up to 3 amino residues per trimer with nearly complete retention ( SIMILAR 80-95 %) of biological activity. The modified TNF amino residues are modified to include long chain fatty acids via TNF lysyl side chains and/or N-terminal amino groups. The disclosed modified TNF molecules provide a highly efficient method for preparing liposome-associated TNF complexes in either standard MLVs or SUVs having enhanced in vivo stability. The binding of said modified TNF molecules to the surface of small unilamellar vesicles is with up to 100 % efficiency. Pharmacologically acceptable preparations of modified TNF for the particular treatment of TNF-responsive tumors are also provided. Methods of preparing liposome associated-lipophilic TNF molecules are provided. The liposomes of the present invention are decribed as small unilamellar vesicles (SUV). The liposomes of the present invention feature particularly small diameters in the range of 0.02 - 0.05  mu m in diameter. Highly efficient methods of preparing stable, surface-associated protein liposome complexes having enhanced stability in vivo are also provided.
Patent DE-69111418-T2 (DE)
Inventor: RESTUCCIA SEBASTIANO
IPC: A63H18/02
Filed: 1991-10-08
Granted: 1996-04-04
Abstract: A module is described which is suitable for forming a toy road track, by linking together a certain number of them by sloting by means of a suitable joint which, as well as making a physical connection, functions as a hinge which allows sinusoidal movement of the track in addition to, obviously, a rectilinear movement. This module also has uni-directionality as a special characteristic, giving the completed track a pleasant aspect, together with extremely simple assembly.
Patent DE-69114458-T2 (DE)
Inventor: KAJIWARA KEN-ICHI
IPC: F04D1/06
Filed: 1991-12-23
Granted: 1996-08-08
Abstract: A multistage centrifugal pump has a plurality of series-connected interstage casings of pressed sheet steel housing respective impellers. Each of the interstage casings includes a central cylindrical side wall, a bottom wall, a first cylindrical wall integrally extending from an end of the central cylindrical side wall and joined to the bottom wall, the first cylindrical wall serving as a male member of a spigot joint, and a second cylindrical wall integrally extending from an opposite end of the central cylindrical side wall and having a flange defining an end opening therein, the second cylindrical wall serving as a female member of a spigot joint. The central cylindrical side wall has an outside diameter larger than outside diameters of the first cylindrical wall and the flange. The interstage casing is formed by drawing and bulging, but not machined to achieve desired dimensional accuracy. Therefore, the interstage casing is free from deformations and dimensional errors which would otherwise tend to occur under forces that would be developed if the blank were fastened for machining, and stresses and heat that would be developed if the blank were machined.
Patent DE-69114904-T2 (DE)
Inventor: AVENATTI GIOVANNI
IPC: B43K25/02
Filed: 1991-04-30
Granted: 1996-05-23
Abstract: The ballpoint pen includes a hollow body (2) and a clip (4) constituted by an annular element (4a) from which a longitudinal element (4b) extends parallel to and outside the body (2). The pen also includes a sleeve-like element (6) which connects the clip (4) to the body (2) and has a lower portion (8) which is fitted in the top (15) of the body (2), an upper portion (12) which extends within the annular element (4a) of the clip (4), the outer end (16) of the upper portion (12) projecting from the annular element (4a) of the clip (4), and a central portion (10) in the form of an annular projection, the sides of which act as abutment surfaces for the base of the annular element (4a) of the clip (4) and for the top (15) of the body (2), respectively. <IMAGE>
Patent DE-69114959-T2 (DE)
Inventor: VESALA REIJO
IPC: F04D7/04
Filed: 1991-09-04
Granted: 1996-04-18
Abstract: A centritugal pump for pumping gas containing fiber suspensions in the pulp and paper industry includes a centrifugal pumping chamber (54) a centrifugal impeller (60) within the pumping chamber; a liquid ring vacuum pump (70) having a radially vaned vacuum pump rotor (96) therein; an intermediate wall (72) separating the pumping chamber (54) from the vacuum pump (70) which has a non-annular volume (146) therein and which provides a passageway between the centrifugal pumping chamber (54) and the vacuum pump (70). A conduit (71) within the intermediate wall (72) is connected to the non-annular volume (146) for introducing a liquid into at least one of the non-annular volume and the vacuum pump (60).
Patent DE-69116735-T2 (DE)
Inventor: TOGANO TAKESHI
IPC: C07D409/12
Filed: 1991-05-27
Granted: 1996-06-13
Abstract: A mesomorphic compound represented by the following formula (I): <CHEM> wherein R1 and R2 respectively denote a linear or branched alkyl group having 1 - 18 carbon atoms capable of including one or two or more non-neighboring methylene groups which can be replaced with -O-, -S-, <CHEM>  -CH=CH-, -C IDENTICAL C- or <CHEM>  wherein X denotes halogen; X1 and X2 respectively denote <CHEM>  Z1 denotes <CHEM>  or -CH2O-; A1 denotes a single bond, <CHEM>   <CHEM> and Y1 and Y2 respectively denote H, F, Cl, Br, -CH3 or -CF3 with the proviso that Y1 and Y2 are not simultaneously H. The mesomorphic compound is effective for providing a ferroelectric liquid crystal composition showing an improved low-temperature operation characteristic and a decreased temperature-dependence of response speed. <IMAGE>
Patent DE-69121119-T2 (DE)
Inventor: DALY EUGENE
IPC: A61M5/00
Filed: 1991-02-07
Granted: 1997-03-06
Abstract: A removal device for removing a hypodermic needle assembly (3) from a syringe (1), wherein the removal device comprises a sleeve (151) provided internally with a series of ribs (153) which engage with a series of ribs (19) on the needle assembly (3), or on an attachment adaptor (6) on the needle assembly (3), when the sleeve (151) is rotated to unscrew the needle assembly (3) from the syringe (2), the sleeve (151) having a clear passage (155) therethrough and having an internal diameter such that the needle assembly (3) and adaptor (6) thereon (if present) can pass freely through it in an axial direction. The sleeve (151) is removably engageable in a hollow shaft (141) through which the needle assembly and adaptor (if present) can drop to a "sharps" container below. The shaft (141) is integrally formed and is power-driven through a gear formation (47) on its external surface. A manually-operated device is also described, having a fixed sleeve as described above in which the needle assembly is held while the syringe is unscrewed from it. A preferred syringe (1) has an open end through which the cartridge (2) can drop when the needle assembly (3) is unscrewed from the syringe. The needle hub (5) or adaptor (6) has a skirt (18) which is internally screw-threaded to engage the front end of the syringe (1). The front end of the cartridge (2) lies within the skirt (18). A removal device for conventional syringes and conventional needle assemblies is also described.
Patent DE-69121602-T2 (DE)
Inventor: GAILLARD PATRICE
IPC: C08F290/04
Filed: 1991-02-12
Granted: 1997-03-27
Abstract: A functionalized multisequenced macromonomer of formula (I) or formula (II), wherein each of blocks A, B and C represents a sequence of a monomer selected from the classes of acrylic, vinylaromatic, methacrylic, diene-containing, vinylpyridine, vinylpyrrolidone, alkylene oxide, lactam, lactone and maleimide monomers, with the proviso that either one or both of blocks A and C is selected from a class different from B, and that at least one of blocks A, B or C is a (meth)acrylic sequence; m, n, and p are integers representing the number of monomer structural units in the sequence in question, e.g.: 3  </=  n  </=  1000, 0  </=  m  </=  1000 and 0  </=  p  </=  1000, with the proviso that m and p are both 0 at the same time; and F is a grouping which terminated by 0<->, OH or an  alpha , beta -ethylene unsaturation.
Patent DE-69131884-T2 (DE)
Inventor: HYPPAENEN TIMO
IPC: B04C5/14
Filed: 1991-10-15
Granted: 2000-06-15
Abstract: The invention relates to a circulating fluidized bed reactor comprising a centrifugal separator and a method for separating particles from gases. The centrifugal separator (12) is a vortex chamber composed of cooling planar plates or panels (32, 34, 36) (i.e. they are distinctly non-cylindrical), having at least one gas inlet (40), at least one gas outlet (52) and at least one outlet (46) for the separated particles. The cross section of the side walls (32, 34, 36) of the vortex chamber forms a distinctly non-circular gas space (31) (e.g. a polygonal cross section), have a circularity of greater than 1, e.g. > 1.1, and preferably > 1.15. One or more vertical, parallel gas vortices may be created in the vortex chamber, the gas introduced into vertical narrow slots. The outlets (46) for separated particles are not one the same symmetrical axes as the outlets for purified gas (52). Two adjacent vortices may be provided in a common rectangular chamber. The separator (12) is preferably in conjunction with a circulating fluidized bed reactor (10).
Patent DE-69209812-T2 (DE)
Inventor: BALZER EDMOND
IPC: E02D29/02
Filed: 1992-09-03
Granted: 1996-10-10
Abstract: An assembly for producing landscaping supports, including a reinforcing element (1) for holding earth and fill (6) in a substantially vertical or inclined plane, a first mat (2) having a plurality of surface openings and provided with seeds and substances for promoting rapid plant growth, said mat being arranged as a facing on the front of said reinforcing element, and a second mat (3) having a plurality of surface openings and provided with substances allowing the above-mentioned plants to take permanent root and colonise the ground, said second mat being arranged on the back of said reinforcing element (1) between it and the earth and fill (6). A method is also provided for producing landscaping support structures by means of said assembly, wherein the first mat (2) is rigidly fastened to the portion of the reinforcing element (1) which will form the front of said structure, said reinforcing element (1) is mounted along with its first mat (2), the second mat (3) is positioned on the back of said reinforcing element (1) in such a way that said second mat (3) is adjacent to said first mat (2), and the earth (6) is backfilled and possibly compacted.
Patent DE-69223321-T2 (DE)
Inventor: DAMES ANDREW
IPC: H01G4/40
Filed: 1992-07-09
Granted: 1998-08-27
Abstract: An antipilferage tag is disclosed which includes a resonant circuit adapted to receive an RF signal and to transmit a response signal when interrogated by said RF signal. The tag includes circuit components constituted by or fabricated from a metallized layer supported by a dielectric material.
Patent DE-69223622-T2 (DE)
Inventor: VACCARI FRANCO
IPC: A43C11/00
Filed: 1992-10-07
Granted: 1998-06-25
Abstract: Sport footwear, comprising a shell (2) with two longitudinally juxtaposed openings (3,4), includes a flexible strap element (15,20,30) extending from one lateral member (2a) of the shell, around the other lateral member (2b) and over the openings on their corresponding closure means (9,11), thereby on adjustably tensioning the strap element across the shell, the latter is brought to fit tightly around the user's foot. <IMAGE>
Patent DE-69227081-T2 (DE)
Inventor: OHNOTA MICHIRO
IPC: C07D277/34
Filed: 1992-02-24
Granted: 1999-05-20
Abstract: A novel thiazolidine-2,4-dione derivative with hypoglycemic and aldose reductase inhibitory activities, represented by general formula (1), a salt thereof, a process for producing the same, and a pharmaceutical containing the same, wherein R<1> and R<2> may be the same or different from each other and each represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, nitro or amino which may be substituted by lower alkyl or lower alkanoyl; R<3> represents hydrogen or lower alkyl; A represents lower alkylene or carbonyl; and B and W are different from each other and each represents lower alkylene, carbonyl or a free bond. <CHEM>
Patent DE-69229219-T2 (DE)
Inventor: HIRAI YOHEI
IPC: C12N15/02
Filed: 1992-10-15
Granted: 1999-11-04
Abstract: A novel physiologically active substance, epimorphine, which can be expressed by a gene hybridizing with a gene probe having a base sequence complemetary to the base sequence represented by the following sequence: ATG CGG GAC CGG CTG CCA GAC CTG ACG GCG TGT AGG which has an activity of epithelial tissue morphogenesis and is produced by human or mouse mesenchymal cells, and an isoform of the epimorphine; a base sequence of a gene which codes for them; a modified epimorphine prepared by replacing a hydrophobic part of the carboxyl terminus of the polypeptide of epimorphine by a defective or non-hydrophobic polypeptide; and a polyclonal or monoclonal antibody prepared by using the whole or part of epimorphine as an antigen. This substance can be used for the clarification of the mechanism of occurrence of diseases caused by the morphological anomaly of epithelia, the diagnosis of these diseases, a development of a therapy therefor, etc.
Patent DE-69229587-T2 (DE)
Inventor: YVIN JEAN-CLAUDE
IPC: A01N65/00
Filed: 1992-10-02
Granted: 2000-01-20
Abstract: The subject of the present invention is a process for treating plant-derived products, especially of marine origin. According to the invention, this process consists, in a first stage, in reacting polyvinylpyrrolidone in solution with at least one plant derivative and in then filtering the reaction mixture thus obtained, for example by ultrafiltration, by microfiltration or by filtration through a horizontal-plate filter. This treatment process makes it possible to potentialise the known biological activity of plant-derived products.
Patent DE-69232310-T2 (DE)
Inventor: DROHAN WILLIAM N
IPC: C12N15/57
Filed: 1992-01-07
Granted: 2002-08-14
Abstract: Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic mammals that incorporate DNAs according to the present invention. Transgenic mammals of the present invention are produced by introducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature mammals and inherited in normal, mendelian fashion.
Patent DE-69321388-T2 (DE)
Inventor: NARDIZ LANDA ISIDRO
IPC: B61F5/32
Filed: 1993-03-26
Granted: 1999-03-04
Abstract: A primary type suspension for railway vehicles consisting of a device capable of providing an independent two-wheel and short shaft bogie with a primary suspension, allowing vertical displacements of the suspension independently of each wheel, maintaining a parallelism and a separation between them by means of an articulated dual connecting rod (1) with two horizontal shafts, which through two bushings (2) coupled to the structure (3) of the bogie itselft, and other two bushings (4) coupled to a part common to the bearing box (6,7) acts as a guide for the suspension spring or springs, and with the help of two articulated bars (12) at its ends coupling the bearing boxes (6,7) to the bogie structure (3), and allowing vertical and parallel displacements of the wheel asembly. <IMAGE>
Patent DE-69325363-T2 (DE)
Inventor: MILLER GRANVILLE
IPC: C09D5/24
Filed: 1993-01-21
Granted: 2000-03-23
Abstract: This invention relates to an anti-corrosive paint comprising a binder and one or more neutral or electrically conductive conjugated homopolymer or copolymers dispersed or dissolved in a liquid medium.
Patent DE-69328033-T2 (DE)
Inventor: GREER WILLIAM
IPC: C12N1/08
Filed: 1993-10-27
Granted: 2000-11-02
Abstract: PCT No. PCT/GB93/02208 Sec. 371 Date Apr. 27, 1995 Sec. 102(e) Date Apr. 27, 1995 PCT Filed Oct. 27, 1993 PCT Pub. No. WO94/10289 PCT Pub. Date May 11, 1994Peroxide, particularly supplied as hydrogen peroxide, is an effective nucleic acid degrading agent and can be used in the recovery of intracellularly produced materials from cell (particularly bacterial) lysates. The degradation or removal of nucleic acids from cell lysates is important because they form solutions of high viscosity which interfere with subsequent processing. Peroxide degradation is particularly useful in the recovery of polyhydroxyalkanoate polymers such as polyhydroxybutyrate/valerate from lysates of bacterial cells in which they are produced.
Patent DE-69328595-T2 (DE)
Inventor: EDGAR ALBERT DURR
IPC: G06F9/44
Filed: 1993-06-07
Granted: 2001-01-04
Abstract: A method, system and process for improving image enhancement tools through the application of expert systems. The improvements are accomplished by the operation of a process in the memory of a processor that enhances an image based on a set of criteria entered by a user. The image is enhanced in at least two ways and the two enhanced images (510, 520) are presented to the user. The user selects the image that appears best and the selected image (530) is thereafter used for subsequent image enhancements according to the user criteria until a final choice of images (550, 560) is presented.   <IMAGE>
Patent DE-69330277-T2 (DE)
Inventor: RICHTER ANNA M
IPC: A61P35/02
Filed: 1993-09-20
Granted: 2002-04-18
Abstract: A method destroys or impairs target cells that have selectively accumulated a photosensitizing agent. The target cells are in the bloodstream of an intact animal, which bloodstream and animal further contain non-target cells. Radiation is applied transcutaneously to at least a portion of the intact animal at an intensity effective to impair or destroy selectively the target cells and to leave non-target cells relatively unimpaired. Target cells include leukemia cells, virus-containing cells, parasite-containing cells, and microorganisms such as bacteria, parasites and free viruses.
Patent DE-69332002-T2 (DE)
Inventor: VAZQUEZ MICHAEL L
IPC: C07C317/14
Filed: 1993-08-24
Granted: 2002-12-19
Abstract: The present invention provides retroviral protease inhibitor compounds represented by the Formula I: <CHEM>   Such compounds are urseful for preparing medicaments for inhibiting proteases, especially for inhibiting HIV protease and for treating a retroviral infection such as HIV infection and for treating AIDS.
Patent DE-69402205-T2 (DE)
Inventor: PETRY RUDY
IPC: B22D11/04
Filed: 1994-07-23
Granted: 1997-08-28
Abstract: PCT No. PCT/EP94/02442 Sec. 371 Date Feb. 28, 1996 Sec. 102(e) Date Feb. 28, 1996 PCT Filed Jul. 23, 1994 PCT Pub. No. WO95/03904 PCT Pub. Date Feb. 9, 1995A description is given of an ingot mould for a continuous casting plant comprising an ingot mould tube (12) and an ingot mould body (22). The ingot mould tube (12) is movable axially with respect to the ingot mould body (22). Sealing elements, preferably metal diaphragms (88, 90) allow an axial displacement of the ingot mould tube (12) with respect to the ingot mould body (22), while ensuring the sealing of a sealed chamber (23) containing the circuit for cooling the ingot mould tube (12). A device for generating mechanical oscillations, preferably a hydraulic cylinder (46), is connected to the ingot mould tube (12) through the intermediary of a lever (54) supported by the ingot mould body (22).
Patent DE-69405992-T2 (DE)
Inventor: PEIGNIER RAYMOND
IPC: A61K31/415
Filed: 1994-05-31
Granted: 1998-03-05
Abstract: 3-arylpyrazole derivatives of the formula    <IMAGE>  (I)  in which X1, X2, X3, X4 and X5, which are the same or different, are H, Hal, nitro, alkyl, alkoxy, Y is H, Hal, nitro, CN, alkyl, alkoxy, alkylthio or an optionally substituted amino; Ra is H, R(alkyl, phenyl, Het), C(V)-V'Ro or C(V)NR0R'0 where: V and V' are O, S; R0 and R'0, H, R, R' optionally substituted by  alpha , which can be GR1, NZ1Z2, SO2NZ1Z2, CVZ1Z2, Rb is H or can form with Ra a hydrocarbon ring of 4-6 C, R1 and R2 are H, R0, R3, G1-T1-Rc, C(O)R0, NTT'. Said fungicides are useful in agriculture.
Patent DE-69423963-T2 (DE)
Inventor: WAHL HOFFMAN
IPC: D06M13/322
Filed: 1994-02-23
Granted: 2000-11-16
Abstract: The present invention relates to softening compounds; stable, homogeneous, preferably concentrated, aqueous liquid and solid textile treatment compositions; and intermediate compositions and/or processes for making said compositions. The compositions of the present invention contain diester quaternary ammonium compounds wherein the fatty acyl groups have an Iodine Value of from greater than about 5 to less than about 100, a cis/trans isomer weight ratio of greater than about 30/70 when the Iodine Value is less than about 25, the level of unsaturation being less than about 65% by weight, wherein said compounds are capable of forming concentrated aqueous compositions with concentrations greater than about 13% by weight at an Iodine Value of greater than about 10 without viscosity modifiers other than normal polar organic solvents present in the raw material of the compound or added electrolyte.
Patent DE-69430503-T2 (DE)
Inventor: SUPPLEE WILLIAM W
IPC: C04B20/12
Filed: 1994-02-08
Granted: 2002-12-12
Abstract: This invention relates to modifying the surface of particles for improved dispersion characteristics in aqueous, solvent, resinous, polymeric, cementitious or the like application systems. In particular, this invention relates to a pigment or filler particle whose surface is coated with at least one electric charge modifying agent and at least one dispersion promoting agent, which has improved dispersibility, coloring, handling, and other processing properties in application systems. The electric charge modifying agent may be selected from the group of Mg, Ca, Ba, Sr, Ti, V, Zr, Cr, Mn, Fe, Co, Ni, Cu, Zn, and Al. The dispersion promoting agent may be selected from the group of stearates, acetates, alkylphenols, cellulosics, waxes, lignins, polyacrylics, polyepoxies, polyurethanes, polyethylenes, polystyrenes and polypropylenes, and polymers having functional groups of alcohols, glycols, aldehydes, amides and carboxylic acids. Iron oxide is the preferred pigment particle.
Patent DE-69432662-T2 (DE)
Inventor: KRAUTSCHNEIDER WOLFGANG
IPC: H03K17/0812
Filed: 1994-02-03
Granted: 2004-03-25
Abstract: In order to restrict the voltage across the gate oxide of an input pass-through transistor which operates as an input signal source to a MOS inverter, an MOS transistor wired as a MOS diode is connected between the source and gate electrode of the pass-through transistor. The diode connected transistor allows the use of a thin oxide device for the pass-through transistor which enables a high transconductance device to be employed while restricting the voltage across the gate oxide of the pass-through transistor to an acceptable value. <IMAGE>