baber/WOPTO huggingface dataset:
Patent AU-716706-B2 (AU)
Title: Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
Inventor: SIEGEL CRAIG S
IPC: C07C323/25
Filed: 1995-12-08
Granted: 2000-03-02
Abstract: Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
Patent AU-627264-B2 (AU)
Title: Double-sided needle assembly
Inventor: IINUMA MITSUHISA
IPC: A61M5/34
Filed: 1990-01-09
Granted: 1992-08-20
Abstract: A double-sided needle assembly includes an insert needle (12) for inserting into vessel; an afflux needle (15) for supplying pharmaceutical liquid in an injector to the insert needle; and a luer member. The member connects the insert needle with the afflux needle through a space (17) defined between the ends of the needles in the member, and holds the insert and afflux needles to fit to the syringe of the injector under pressure. The confirmation of the insertion of the insert needle into the vessel is accomplished by the observing the space of the luer member.
Patent AU-781371-B2 (AU)
Title: Film structures containing oxygen scavenging compositions and method of application
Inventor: HUNT THOMAS F
IPC: B05D5/00
Filed: 2000-05-05
Granted: 2005-05-19
Abstract: A polymeric film structure having one or more polymeric layers wherein an oxygen scavenging composition is affixed to the inside surface layer of the structure. The structure having usefulness in the packaging of foods and non-food articles wherein an oxygen free or a relative oxygen free environment is desirable for the contained article. The oxygen scavenging composition comprising a primer layer; a pigmented layer, an oxygen scavenger layer and an overcoat layer wherein each layer is applied one or more times to the polymeric film structure by a printing method preferably a flexographic printing process.
Patent AU-617927-B2 (AU)
Title: Polymers of carbon monoxide with mono-olefins
Inventor: WONG PUI KWAN
IPC: C08G67/00
Filed: 1990-02-28
Granted: 1991-12-05
Abstract: Novel copolymers of carbon monoxide with one or more optionally alkyl-substituted cyclopentenes, are obtainable by contacting the monomers with a catalyst composition solution comprising: (a) a palladium compound, (b) an anion of an acid with a pKa of less than 2, and (c) a bidentate ligand containing phosphorus, sulphur or nitrogen, with the proviso that when a bidentate ligand chosen from nitrogen, sulphur or aromatic phosphorus containing compounds is used as component (c), the catalyst composition additionally comprises a meta-dinitrobenzene compound as component (d).
Patent AU-639906-B2 (AU)
Title: Metastasis-associated collagenolytic metalloproteinases
IPC: C12N15/02
Filed: 1990-01-29
Granted: 1993-08-12
Abstract: Disclosed are methods and compositions for testing for various types of human cancers, including in particular metastatic mammary carcinoma, colon carcinoma astrocytoma, renal cell carcinoma, and teratocarcinoma malignant melanoma. The diagnostic method of the invention involves the detection of a gelatinolytic and type IV collagenolytic metalloproteinase having molecular weight of approximately 88 to 92 kilodaltons in size. This high molecular weight type IV collagenolytic enzyme is found to be associated with the cancerous state, but this has not been found in any noncancerous cells tested and further not found in the serum of non tumor bearing animals. The enzyme is associated both with rat and human tumors, the enzyme in each case being quite similar. Methods are disclosed for isolating the 88/92 kd enzyme, the isolated enzyme being useful as a control enzyme and diagnostic assays. Furthermore, the isolated enzyme will be useful in the preparation of antibodies, including monoclonal antibodies, having specificity for the metastasis-associated enzyme. Techniques are also disclosed for isolation and partial purification of the enzyme from both rat and human sources. Furthermore, methods are disclosed for conducting both enzymatic and immunologic based tests for the diagnosis of metastatic and recurrent disease.
Patent AU-586220-B2 (AU)
Title: Composition and method for treatment of tumors with udpg
Inventor: BALIS M EARL
IPC: C07H19/10
Filed: 1985-12-17
Granted: 1989-07-06
Abstract: UDPG shows tumor-specific inhibition of PRPP and this suggests that this action might prove to be useful in combination therapy with inhibitors of purine and pyrimidine nucleotide systhesis in various rescue regimens. High levels of PRPP in tumors were greatly affected by treatment with UDPG. UDPG can be used in treatment in conjuction with other anti-tumor drugs such as methotrexate, 6-mercaptopurine, 5-fluorouracil or 2,6-dimercaptopurine.
Patent AU-777124-B2 (AU)
Title: Silicon carbide composites and methods for making same
Inventor: WAGGONER W MICHAEL
IPC: C04B35/573
Filed: 1999-07-23
Granted: 2004-09-30
Abstract: Improved silicon carbide composites made by an infiltration process feature a metal phase in addition to any residual silicon phase. Not only are properties such as mechanical toughness improved, but the infiltrant can be so engineered as to have much diminished amounts of expansion upon solidification, thereby enhancing net-shape-making capabilities. Further, multi-component infiltrant materials may have a lower liquidus temperature than pure silicon, thereby providing the practitioner with greater control over the infiltration process. In particular, the infiltration may be conducted at the lower temperatures, where low-cost but effective bedding or barrier materials can terminate the infiltration process once the infiltrant has migrated through the permeable mass up to the boundary between the mass and the bedding material.
Patent AU-669590-B2 (AU)
Title: Power distribution system
Inventor: ROTGER JOSE FELIX SANCHO
IPC: H02J13/00
Filed: 1994-01-18
Granted: 1996-06-13
Abstract: Consisting of an alternating current distributor (1) that delivers the current coming from the mains (11) to a set of racks (21, 22) each one equipped with a certain number of converters (5), a rack control module (6) and a battery (3), it being possible to configure a centralised or distributed parallel arrangement, and which feed a load (4). In order to optimise the sharing of resources, one of the racks has a plant control module (8) that has the function of overall system control, generating commands for configuration, control and supervision, that are sent to the rest of the racks (22) via a communications channel (7). <IMAGE>
Patent AU-764992-B2 (AU)
Title: TNF-derived peptides for use in treating oedema
Inventor: LUCAS RUDOLF
IPC: A61K/
Filed: 1999-08-10
Granted: 2003-09-04
Abstract: The present invention relates to the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF- alpha ) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF- alpha  from Ser<100> to Glu<116> to treat pulmonary oedema. Moreover, the present invention concerns a circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC which is very efficient in inducing oedema resolution.
Patent AU-741210-B2 (AU)
Title: Spine distraction implant and method
Inventor: ZUCHERMAN JAMES F
IPC: A61B17/70
Filed: 1997-12-23
Granted: 2001-11-22
Abstract: A spinal distraction implant alleviates pain associated with spinal stenosis, and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion. The implant comprises: 
a first implant member (22) having an upper surface configured to contact an inferior portion of a first spinous process; and 
a second implant member (24) having a lower surface configured to contact a superior portion of a second spinous process; wherein 
the second implant member is movably coupled to the first implant member such that the upper surface of the first implant member is displaceable away from the lower surface of the second implant member.
Patent AU-647743-B2 (AU)
Title: Detachable two piece absorbent garment
Inventor: GIPSON WILLIAM PATRICK
IPC: A61F13/66
Filed: 1990-07-17
Granted: 1994-03-31
Abstract: A two piece garment for collecting bodily discharges is disclosed. The garment has a belt and a disposable assembly which are detachable and reattachable. The belt is intended to be reused, while the disposable assembly is intended to be discarded when soiled. The two components are attached to one another by hook and loop type fastening material, providing for adjustment to fit a wide range of wearer sizes.
Patent AU-631234-B2 (AU)
Title: Preparation of carbon monoxide/olefin polymers using two or more reactors in series
IPC: C08G67/00
Filed: 1990-08-06
Granted: 1992-11-19
Abstract: Process for the preparation of polymers, wherein linear polymers of carbon monoxide with one or more olefinically unsaturated compounds, in which polymers the units originating in carbon monoxide on the one hand and the units originating in the olefinically unsaturated compounds on the other hand occur substantially in alternating order, are prepared in a continuous manner by contacting the monomers with a suitable catalyst at an elevated temperature and pressure in two or more reactors connected in series.
Patent AU-624017-B2 (AU)
Title: Bone cement for sustained release of substances
Inventor: POSEY-DOWTY JESSICA
IPC: C08F20/10
Filed: 1990-08-17
Granted: 1992-05-28
Abstract: A bone cement is disclosed wherein the liquid component contains a therapeutic or diagnostic substance in combination with an emulsifying agent for said substance.
Patent AU-703417-B2 (AU)
Title: Universal primer sequence for multiplex DNA amplification
Inventor: SHUBER ANTHONY P
IPC: C12Q1/68
Filed: 1996-06-06
Granted: 1999-03-25
Abstract: The present invention provides primer that allow simultaneous amplification of multiple DNA target sequences present in a DNA sample. Further provided are methods for detecting multiple defined target DNA sequences in a DNA sample. Methods for high-throughput genetic screening are also provided. In yet another aspect, the present invention provides single-stranded oligonucleotide DNA primers for amplification of a target DNA sequence in a multiplex polymerase chain reaction.
Patent AU-627355-B2 (AU)
Title: Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity
Inventor: CHANDRARATNA ROSHANTHA A S
IPC: A61K31/47
Filed: 1990-09-17
Granted: 1992-08-20
Abstract: Retinoid-like activity is exhibited by compounds of the formula <CHEM> where X is S, O or NR min ; where R min  is hydrogen or lower alkyl; R1, R2 and R3 are hydrogen or lower alkyl; R4 and R5 are hydrogen or lower alkyl with the proviso that R4 and R5 cannot both be hydrogen, A is pyridyl, thienyl, furyl, pyridazinyl, pirimidinyl, pyrazinyl, thiazolyl or oxazolyl; n is 0 - 5, and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.
Patent AU-715944-B2 (AU)
Title: Plants which synthesize a modified starch, process for the production thereof and modified starch
Inventor: KOSSMANN JENS
IPC: A23L5/10
Filed: 1996-09-19
Granted: 2000-02-10
Abstract: New nucleic acid (I) encoding a protein (P), present in plant cells in both soluble form and bound to starch granules, (a) encodes a 1464 amino acid (aa) of (P) reproduced in the specification; (b) includes the coding region of a 4856 bp sequence reproduced in the specification; (c) can hybridise with (a) or (b); (d) is degenerate, within the genetic code, with (a)-(c) or (e) is a fragment, deriv. or allelic variant of (a)-(d). Also claimed are: (1) DNA (II) encoding RNA that is antisense to a (I) transcript, has ribozyme activity on this transcript or which when expressed in a plant cell reduces expression of (I) by a co-suppressant effect; (2) nucleic acid fragments (III) of at least 15 nucleotides that hybridise specifically with (I); (3) plants contg. cells contg. (I) or (II); and (4) starch obtained from these plants.
Patent AU-676756-B2 (AU)
Title: Silica scale inhibition
Inventor: BARDSLEY JUDY HUGHES
IPC: C02F5/10
Filed: 1994-09-09
Granted: 1997-03-20
Abstract: A method is provided for inhibiting silica or silica scale formation in aqueous systems using (a) selected low molecular weight (meth)acrylic or maleic acid based copolymers or terpolymers.
Patent AU-709338-B2 (AU)
Title: New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
Inventor: SOLDATO PIERO DEL
IPC: A61K31/60
Filed: 1996-10-29
Granted: 1999-08-26
Abstract: PCT No. PCT/EP36/04696 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 29, 1996 PCT Pub. No. WO97/16405 PCT Pub. Date May 9, 1997Compounds and their compositions, of general formula: A-X1-NO2 are used as medicaments wherein: A=R(COX)t t=0 or 1; X=O and the remaining substituents are defined in the specification.
Patent AU-758918-B2 (AU)
Title: Fabric care composition
Inventor: PARKER ANDREW PHILIP
IPC: C11D3/37
Filed: 2000-09-27
Granted: 2003-04-03
Abstract: Fabric care compositions adapted for use in a laundering process such as detergent compositions and laundry rinse compositions, comprise at least one reactive cationic polymer (preferably amine- or amide-epichlorohydrin resin or a derivative thereof), at least one reactive anionic polymer and at least one textile compatible carrier. The compositions have improved dye transfer and stain release properties and may be used in methods of treating fabric as part of a laundering process.
Patent AU-694745-B2 (AU)
Title: Uses of green fluorescent protein
Inventor: CHALFIE MARTIN
IPC: C12Q1/68
Filed: 1994-09-09
Granted: 1998-07-30
Abstract: PCT No. PCT/US94/10165 Sec. 371 Date Jun. 18, 1996 Sec. 102(e) Date Jun. 18, 1996 PCT Filed Sep. 9, 1994 PCT Pub. No. WO95/07463 PCT Pub. Date Mar. 16, 1995This invention provides a cell comprising a DNA molecule having a regulatory element from a gene, other than a gene encoding a green fluorescent protein operatively linked to a DNA sequence encoding the green fluorescent protein. This invention also provides living organisms which comprise the above-described cell. This invention also provides a method for selecting cells expressing a protein of interest which comprises: a) introducing into the cells a DNAI molecule having DNA sequence encoding the protein of interest and DNAII molecule having DNA sequence encoding a green fluorescent protein; b) culturing the introduced cells under conditions permitting expression of the green fluorescent protein and the protein of interest; and c) selecting the cultured cells which express green fluorescent protein, thereby selecting cells expressing the protein of interest. Finally, this invention provides various uses of a green fluorescent protein.
Patent AU-549067-B2 (AU)
Title: Swing-arm device for optical scanning unit
Inventor: VEERDONK JOHANNES THEODORUS AD
IPC: G11B7/08
Filed: 1982-08-23
Granted: 1986-01-09
Abstract: A swinging-arm device (5) for an optical disk player comprises a swinging arm (16), which near one end (17) carries an optical scanning unit (6) and which is electromagnetically pivoted by means of coils (27, 28) arranged on the swinging arm and a permanent magnetic stator (29, 30, 49-52, 54) arranged on a stationary mounting of the device. The centre of mass (Z) of the pivotal assembly comprising, inter alia the swinging arm and the optical scanning unit is disposed on the pivotal axis and the two coils are disposed diametrically opposite one another on opposite sides of the pivotal axis and exert equal pivotal forces which act in one plane which is perpendicular to the pivotal axis and which extends through the centre of mass. The centre of mass is disposed midway between two ball-bearings (20, 21).
Patent AU-650929-B2 (AU)
Title: Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents
Inventor: KAMESWARAN VENKATARAMAN
IPC: C07D207/42
Filed: 1991-12-16
Granted: 1994-07-07
Abstract: There is provided a synthesis of 2-aryl-5-(trifluoromethyl)pyrrole compounds of formula I via the condensation of a suitable enamine with an  alpha -haloketone. <CHEM> 2
Patent AU-747823-B2 (AU)
Title: Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
Inventor: DASSEUX JEAN-LOUIS
IPC: A61P31/04
Filed: 1998-09-28
Granted: 2002-05-23
Abstract: The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
Patent DE-1800430-B2 (DE)
Title: Cutter change arrgmt. for machine tools - mounted on hub parallel to tool spindle
IPC: B23Q3/155
Filed: 1968-10-01
Abstract: The tool change arrangement can be moved by a mechanism between a front and a back position. It is mounted on a hub and can be rotated relative to the machine tool. Grips are mounted at the end of radial arms, which can grip a cutter and move it from a storage into a working position. The axis of rotation of the hub on which the tool changers are mounted is placed at an angle to the axis of rotation of the work spindle. The arms which extend from the hub are also mounted at an angle relative to the direction of rotation of the hub. The angle between the arms and a plane at right angles so their axis of rotation is equal to the angle between the axis of rotation of the spindle and the axis of rotation of the hub.
Patent DE-2021487-B2 (DE)
Title: Atmospherically open expansion vessel for central heating - can be installed vertical or horizontal and has temporary plug connectors
IPC: F24D3/10
Filed: 1970-05-02
Abstract: The design is intended to reduce the number of different types of expansion vessel which has to be stocked. The cylindrical vessel is fitted with connectors for flow and return safety pipes for both the upright or horizontal position. The pipes are linked through bypass heater pipes inside the vessel. The pipe in use is fitted with a thermostatic valve to control flow according to the water temperature in the vessel. Unused connectors and openings are sealed. The pipe configuration ensures that no excessive circulation of water is set up inside the vessel. This reduces oxygen absorption and corrosion.
Patent DE-2048988-B2 (DE)
Title: Drag reduction for marine hull - has pressure controlled bubble layer provided under hull by air supply to perforated bulkhead
IPC: B63B1/38
Filed: 1970-09-29
Abstract: The front end of the hull is provided with a transverse duct under the waterline and with exist slots (38) through which a stream of bubbles forms a drag reducing carpet. The duct is divided into two halves by a perforated bulkhead (34) so that an even pressure control is achieved to provide an even carpet. The bulkhead ensures that a controlled airflow is achieved to the exit chamber (36) while distribution of the exit slots (38) to the water is greater with increasing depth and water pressure. A single air supply can be used with the duct geometry ensuring and even carpet.
Patent DE-2059815-B2 (DE)
Title: Flat item inversion machine - has first and second twisted overlapping belts with third belt at right angles
IPC: B65G47/248
Filed: 1970-12-04
Abstract: The machine is particularly for furniture panels as they are continuously transported, turning them upside down about the lengthwise axis of the conveyor. It has an erection surface twisting in the direction of inversion from the horizontal plane, the end of which is overlapped by a receiver surface twisting the rest of the way, both these surfaces being overlapped by an endless conveyor belt acting as a supporting surface. The erection and receiver surfaces are first and second twisted conveyor belts (1, 2) and the belt acting as the supporting surface (7) is so twisted that its surface is always at right angles to those of the other two. The minimum clearance between the first and second belts where they overlap can be greater than the thickness of the items handled.
Patent DE-2112476-B2 (DE)
Title: Zero voltage switch for thyristor power supply - has unijunction transistor in series with resistor across capacitor charged via resistor from control voltage source
IPC: H03K17/13
Filed: 1971-03-16
Abstract: The electronic switch operates when the ac supply being switched passes through zero and consists of a thyristor (16) in series with the load (17). The thyristor's gate is coupled via a transformer to a drive transistor's (11) output. The drive transistor is controlled by a unijunct on transistor (4) connected in series with a resistor (5). A capacitor (3) shunts this series combination and is charged via a resistor (2) from the dc source (1). The capacitor's charging voltage is chosen so that it is less than the ac supply's peak.
Patent DE-2136665-B2 (DE)
Title: Tipper frame for container mounted on lorry - is fitted with front edge support bolts which are clamped to tipping yoke and weight of container is evenly spread
IPC: B60P1/16
Filed: 1971-07-22
Abstract: The tipper frame for the container lorry has the container secured by its corner tags. The rear edge of the container has its tags secured on pivoted securing bolts so that the container can be tipped over the rear edge. For a more secure hold, with some of the load taken off these tags, the front tags (9, 5) are secured on bolts (1213) at the ends of a support yoke (24). The yoke is fitted with two parallel, telescopic rams (20) which are used to lift and tip the container. The weight of the container is thus evenly spread over the four corners of the container.
Patent DE-2140951-B2 (DE)
Title: Rubber membranes with thickened edges prodn. - by punching body from vulcanised latex film and glueing flexible frames to edges
IPC: F16J3/02
Filed: 1971-08-16
Abstract: Membranes with a thickened edge are produced by (a) preparing a film from a rubber latex by a dip process, (b) vulcanising the rubber film, (c) punching-out a base body from the vulcanised film, (d) glueing onto each side of the base body at least one frame e.g. of paper, plastics, leather or fabric, by use of permanently elastic adhesive and pressure, and (e) providing the final contour of the membrane by punching-out the laminated body/frame. The flexible frame enables the membrane to be converted to any desired shape, while retaining its initial elastic properties. Damage to the film during prodn. of the membrane is avoided. The frame provides the membrane with a good resistance to tearing, and does not interfere with the stretching of the membrane. The adhesive provides a good elastic bond between the frame and membrane.