Patent SG-11201906552W-A (SG)
Title: TGF-ß DECOY RECEPTOR
Inventor: CONNOLLY JOHN
IPC: C07K14/71
Filed: 2018-01-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT 0111111010 0111 °nolo oil! ommoniiiiniou oimIE (10) International Publication Number WO 2018/138003 Al (51) International Patent Classification: C07K 14/71 (2006.01) A61K 38/00 (2006.01) C07K 14/715 (2006.01) (21) International Application Number: PCT/EP2018/051287 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/450,468 25 January 2017 (25.01.2017) US (71) Applicant: TESSA THERAPEUTICS PTE. LTD. [SG/SG]; 8 Temasek Boulevard, #24-02 Suntec Tower 3, 038988 (SG). (71) Applicant (for LS only): CLEGG, Richard Ian [GB/GB]; City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (72) Inventors: CONNOLLY, John; C/o 8 Temasek Boule- vard, #24-02 Suntec Tower 3, 038988 (SG). HOPKINS, Richard; C/o 8 Temasek Boulevard, #24-02 Suntec Tow- er 3, 038988 (SG). ONG, Yijie Philbert; C/o 8 Temasek Boulevard, #24-02 Suntec Tower 3, 038988 (SG). PE- TERSEN, Sven Hans; C/o 8 Temasek Boulevard, #24-02 Suntec Tower 3, 038988 (SG). (74) Agent: CLEGG, Richard et al.; Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: TGF-B DECOY RECEPTOR (57) : A TGF-13 decoy receptor comprising a TGF-13 binding region and a lipid anchor region is disclosed. Also disclosed is a chimeric antigen re- ceptor (CAR) comprising a TGF-13 binding region. Also disclosed are compo- sitions comprising, and methods using, the TGF-13 decoy receptors and CARs. W O 20 18/ 138003 Al TGF0R2 ECD-CD48 GPI MG RGLLRGLWPLH IVLWTRIASTI PPHVOKSDVEM EAQKDEI I CPSCN RTAH PLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEK PQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGE TFFMCSCSSD ECN DNI I FSE EYNTSNPDVCSPPCTLARSFGVEW IASWLVVT VPTILGLLLT (SEQ ID NO:5) TGF0R2 ECD-CD55 GPI MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAH PLRHINNDMIVTDNNGAVKFPOLCKFCDVRESTCDNQKSCMSNCSITSICEK PQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGE TFFMCSCSSD ECN DNI I FSE EYNTSNPH ETTPNKGSGTTSGTTRLLSGHTCF TLTGLLGTLVTMGLLT (SEQ ID NO:6) TGFOR2 ECD-PLAC ALKPHOS GPI MG RGLLRGLWPLH IVLWTRIASTI PPHVQKSDVEM EAQKDEI I CPSCN RTAH PLRHINNDMIVTDNNGAVKFPOLCKFCDVRESTCDNQKSCMSNCSITSICEK PQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGE TFFMCSCSSD ECN DNI I FSE EYNTSNPTACDLAPPAGTTDAAHPG PSVVPAL I pi I AG - 11111 GTATAP (SEQ ID NO:7) TGFOR2 ECD-CD90 GPI MG RGLLRGLWPLH IVLWTRIASTI PPHVQKSDVEM EAQKDEI I CPSCN RTAH PLRHINNDMIVTDNNGAVKFPOLCKFCDVRESTCDNOKSC MSNCSITSICEK PQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGE TFFMCSCSSDECNDNIIFSEEYNTSNPNVTVLRDKLVKCEGISLLAQNTSWLL I I SI SI MATDEMS1 (SEQ ID NO:8) TGFPR2 leader sequence TGFpR2 ECD; GPI signal sequence co residue Figure 1 [Continued on next page] WO 2018/138003 Al MIDEDIMOHNIIMEIDIDEMIOMMONIMMOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))