baber/WOPTO huggingface dataset:
Patent PT-1652526-E (PT)
Title: Use of (11beta, 17beta)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one in the treatment of major depressive disorder
Inventor: SENNEF CORNELIS
IPC: C07J9/00
Filed: 2002-10-21
Abstract: The present invention relates to the use of the glucocorticoid receptor antagonist (11²,17²)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one (Org 34517) for the preparation of a medicament for the treatment of depression as well as to pharmaceutical preparations of Org 34517 for said use.
Patent PT-1968983-E (PT)
Title: Method for preparing a mixed solvate of olanzapine
Inventor: BARJOAN PERE DALMASES
IPC: C07D495/04
Filed: 2006-12-20
Abstract: An improved method is provided for preparing a mixed solvate of olanzapine/water/tetrahydrofuran in a proportion of 1:1:1/2. Said improvement is characterised in that said mixed solvate is basically prepared by means of methylation of the N-desmethylolanzapine with dimethyl sulphate, using tetrahydrofuran and water as solvents.
Patent PT-2082131-E (PT)
Title: Mast for a wind turbine
Inventor: ROEST ANTON HERRIUS DE
IPC: F03D1/00
Filed: 2008-03-07
Abstract: The mast (10) narrows towards the top and has at least two annular mast sections (12,14,16,18,20), one on top of the other, whereby a mast section consists of a number of prefabricated wall parts, of which at least some have a curved section. At least the curved sections of the prefabricated wall parts in different annular mast sections are identical, at least in cross-section.
Patent PT-2180007-E (PT)
Title: Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
Inventor: UMANA PABLO
IPC: C07K16/00
Filed: 1999-04-20
Abstract: The present invention provides a method for generating a host cell that produces a recombinant antibody with enhanced Fc-mediated cellular cytotoxicity, comprising: providing a host cell that is capable of expressing a recombinant antibody comprising an IgG Fc region containing N-linked oligosaccharides and genetically modifying the host cell to alter the glycosylation pattern of the antibody; wherein said recombinant antibody has an increased proportion of GlcNAc residues in the Fc region relative to the proportion of fucose residues and has increased Fc-mediated cellular cytotoxicity compared to the corresponding antibody produced by the same host cell that has not been genetically modified. The present invention also provides a method for producing a protein compound having enhanced Fc-mediated cellular cytotoxicity in a host cell. The present invention further provides a glycosylation engineered host cell that expresses a recombinant antibody comprising an IgG Fc region containing N-linked oligosaccharides, wherein said host cell has been genetically modified to regulate the expression of at least one nucleic acid encoding a glycoprotein modifying enzyme, and wherein said antibody has increased ADCC.
Patent PT-706571-E (PT)
Inventor: ANDERSEN PETER
IPC: C12N1/21
Filed: 1994-07-01
Abstract: Diagnostic methods capable of discriminating between cell mediated immunologic responses due to on the one hand active tuberculosis caused by bacteria belonging to the tuberculosis complex (Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis) and on the other hand vaccination with an immunogenic agent conferring immunity to tuberculosis. A diagnostic kit is also provided, comprising a polypeptide (e.g. MPT64) capable of eliciting a delayed type hypersensitivity reaction (Dth) in animals with active tuberculosis, but not in animals vaccinated against TB with an immunogenic agent (e.g. M. bovis BCG strain: Danish 1331). Vaccination with certain BCG strains is thus possible without interfering with the diagnosis of active tuberculosis. Also provided are polypeptide fragments comprising a T-cell epitope of MPT64 as well as nucleic acid fragments encoding these polypeptide fragments.
Patent PT-758101-E (PT)
Inventor: FITZGERALD KEVIN A
IPC: B65H75/16
Filed: 1996-08-07
Abstract: A reloadable film canister system provides light-tight and dust-free enclosure for 105 mm microfilm and the like. A gear-toothed reel inside the canister (125) meshes with a gear assembly (130, 132, 141, 142) of the canister (125) and linearly drives a detectable element (149) adjacent a sensing element located in a host machine. <IMAGE>
Patent PT-767348-E (PT)
Inventor: IDE SATOSHI
IPC: C09K5/04
Filed: 1996-04-15
Abstract: A method of filling a refrigerant mixture comprising a nonazeotropic mixture composed of difluoromethane, pentafluoroethane and 1,1,1,2-tetrafluoroethane contained in an allowable range of respective quantities of 22-24 %, 23-27 % and 50-54 %, wherein the mixture is drawn out of the liquid phase in the container on the feed side while adjusting the percentage composition thereof to 23.5-24.0 % difluoromethane, 25.5-26.0 % pentafluoroethane and 50.0-51.0 % 1,1,1,2-tetrafluoroethane to thereby control the compositional change resulting from refrigerant transfer to fall within the above allowable range; and a process for producing a vapor-compression refrigerator. <IMAGE>
Patent PT-896842-E (PT)
Inventor: DALLAN SERGIO
IPC: B21D43/08
Filed: 1998-07-09
Abstract: A punching machine for sheet metal in the form of individual sheets or strip, comprising at least one punching head (4) and means for conveying the sheet metal (6) relative to said head on the basis of the predetermined working cycle, characterised in that said conveying means consist of a pair of feeders (8, 8') positioned upstream and downstream of said punching head and coordinated in their operation in relation to the type of sheet metal to be worked. <IMAGE>
Patent PT-1032386-E (PT)
Inventor: BATTS DONALD H
IPC: A61K31/496
Filed: 1998-11-10
Abstract: The present invention is a method of treating a person who has psoriasis or arthritis or reducing the toxicity of cancer chemotherapy which comprises administering to the patient an anti-psoriasis effective amount of an oxazolidinone, preferably (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide.
Patent PT-992501-E (PT)
Inventor: KURAMOTO YASUHIRO
IPC: C07D205/04
Filed: 1996-09-20
Abstract: Pyridine carboxylic acid derivs. of formula (I) and their salts are new: R1 = H or carboxy protecting gp; R2 = OH, lower alkoxy or opt. substd. amino; R3 = H or halo; R4 = H or halo; R5 = halo or opt. substd. cyclic amino; R6 = H, halo, NO2 or opt. protected amino; X, Y, Z = N, CH or CR7; R7 = lower alkyl, halo or CN; provided that \- 1 of X-Z = N; W = N or CR8; R8 = H, halo or lower alkyl.
Patent PT-1054788-E (PT)
Inventor: PETERSON KENNETH C
IPC: B60R1/04
Filed: 1999-02-16
Abstract: A dimming mirror assembly has a housing, a reflective member, a transparent member, a light reducing medium, and an actuating mechanism for introducing and evacuating the light reducing medium disposed in a gap between the transparent member and the reflective medium. The reflective member and the transparent member are carried by the housing. At least one of the transparent member and the reflective member is moveable relative to the other. The amount of light transmitted to and reflected from the reflective member is a function of the volume of light reducing medium therebetween, the volume being variable by effecting relative movement between the reflective and transparent members. The controlling mechanism may include an actuating mechanism for effecting the relative movement between the reflective and transparent members.
Patent PT-1105574-E (PT)
Inventor: SORENSEN ELMGAARD BIRGER
IPC: D21F9/00
Filed: 1999-07-13
Abstract: A plant which serves to produce a nonwoven web of fibers out of a fibrous material, such a cellulose pulp. The plant comprises a hammer mill for defibrating the fibrous material and a forming head for forming a web of fibers on an endless forming wire, which, during operation, runs mainly horizontally, a first transport fan for transporting defibrated fiber to the forming head via a first air duct and a second transport fan to extract nits from the forming head via a second air duct. Furthermore, the plant comprises a separator, which is connected to the second air duct and arranged for separating the nits and the well-opened fiber, a third transport fan for returning the separated, well-opened fibers to the forming head, and a nits-opener for converting the separated nits into well-opened fiber. The separated nits are transported from the nits separator to the nits-opener by means of a fourth transport fan via a fourth air duct. The defibrated fibers are returned to the forming head by means of a fifth transport fan via a fifth air duct. The plant is easy to control and is capable of producing optimally high quality fiber products. In addition, the plant allows the defibrator to defibrate new fiber material at full capacity so that the remainder of the plant is able to produce at an optimum output level. The plant is furthermore very energy-saving.
Patent PT-1107746-E (PT)
Inventor: JERUSSI THOMAS P
IPC: A61K31/135
Filed: 1999-08-23
Abstract: Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional disorders, pain, obsessive-compulsive disorder, substance abuse, chronic disorders, anxiety, eating disorders, migraines, incontinence, depresson, attention deficit disorder, attention deficit disorder with hyperactivity, bipolar and manic conditions, dysthymic disorder, and cyclothymic disorder, senile dementia, Alzheimer's type dementia, memory loss, amnesia/amnestic syndrome, disturbance of consciousness, coma, lowering of attention, speech disorders, Parkinson's disease, Lennox syndrome, autism, epilepsy, hyperkinetic syndrome and schizophrenia. The methods comprise the administration of a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Pharmaceutical compositions and dosage forms are also disclosed that comprise a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Preferred dopamine reuptake inhibitors are racemic or optionally pure sibutramine metabolites, wherein the sibutramine metabolite is selected from the group consisting of (+)-desmethylsibutramine, (-)-desmethylsibutramine, (±)-desmethylsibutramine, (+)-didesmethylsibutramine, (-)-didesmethylsibutramine, and (±)-didesmethylsibutramine.
Patent PT-1140807-E (PT)
Inventor: GUERRET OLIVIER
IPC: C07C291/04
Filed: 1999-12-22
Abstract: The invention concerns a method for preparing nitroxides, which consists in oxidising, in a two-phase medium, using an aliphatic peroxide, secondary amines with steric hindrance or having a -CH in the nitrogen atom alpha.
Patent SG-88690-G (SG)
Title: Charge-coupled semiconductor device with dynamic control
IPC: G11C19/28
Filed: 1990-10-25
Abstract: In a CCD, especially in an image sensor device, the information density can be doubled in that the electrodes (21, 22, 31, 32...) are switched separately between a clock signal and a reference signal. Clock signals and reference signals are obtained as output signals of a shift register (13) controlled by a multi-phase clock, which is realized, for example, in C-MOS technology. Information at the input terminal (107) of the first stage (101) of the shift register (13) determines, after having been passed on or not having been passed on depending upon the clock pulse signals of the register clock, the output signal of the next stages (101) of the shift register (13) and hence the voltage variation at the electrodes (21, 22, 31, 32...) connected to the outputs (113) of the stages (101).
Patent IE-870004-L (IE)
Title: Optically pure compounds.
IPC: C07D211/60
Filed: 1987-01-02
Abstract: Optically pure S-(-)-l-propyl-2 min ,6 min -pipecoloxylidide hydrochloride monohydrate, with the structural formula <CHEM> a process for the preparation thereof and the use for inducing local anesthesia.
[EP0239710A1]
Patent IE-820249-L (IE)
Title: Pyrrolidine derivatives
IPC: C07D207/273
Filed: 1982-02-04
Abstract: 1-(3-Hydroxy-4-methoxybenzoyl)-3-hydroxy-2-pyrrolidinone of the formula <IMAGE> I suitable for the control or prevention of cerebral insufficiency is described. The compound contains an asymmetric carbon atom. Therefore, the two optically active enantiomeric forms as well as the racemate are described. The compound of formula I can be prepared by cleaving the protecting group(s) from a corresponding compound in which at least one of the two hydroxy groups is protected.
[US4452807A]
Patent IE-860261-L (IE)
Title: Cubic boron nitride abrasive body
IPC: C04B35/58
Filed: 1986-01-29
Abstract: A sintered cubic boron nitride body is produced by mixing a mass of cubic boron nitride particles with a salt-like nitride or a mixture of such nitrides and subjecting the mixture to elevated temperature and pressure conditions at which the cubic boron nitride is crystallographically stable. The nitride or nitrides in the mixture are present in an amount of no more than 2 mole percent of the mixture. The sintered body thus produced may be crushed to a mass of smaller bodies or particles. The strength of these bodies or particles may be increased by subjecting them, or the sintered body before crushing, to a heat treatment at a temperature of 1000 DEG C to 1300 DEG C for 5 to 60 minutes.
Patent IE-810292-L (IE)
Title: Preparing esters
IPC: C07C43/303
Filed: 1981-02-13
Abstract: Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals in the presence of a Lewis acid.The reaction is preferably carried out in the presence of catalytic amounts of a Lewis acid and of a diluent at a temperature in the range from about 0° to the reflux temperature of the diluent.The esters thus obtained are useful as intermediate products for preparing drugs.The process involves the preparation of new alpha-haloketals.
Patent IE-850608-L (IE)
Title: Process for the recovery of ceftazidime
IPC: C07D501/00
Filed: 1985-03-08
Abstract: A process for recovering ceftazidime from an aqueous solution containing it, said solution being at a pH in the range 2.0 to 5.5, which comprises contacting the said solution with a non-functional macroreticular resin suitable for adsorbing ceftazidime, eluting the ceftazidime and isolating it, if desired in the form of a salt or hydrate.
[US4769450A]
Patent IE-820819-L (IE)
Title: Peptides
IPC: C07K7/06
Filed: 1982-04-06
Abstract: Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure.  X-R1-R2-R3-Ser-Tyr-R4-R5-Arg-Pro-R6 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R1 is dehydro Pro or dehydro D-Pro; R2 is D-Phe, Cl-D-Phe, dichloro-D-Phe, CF3-D-Phe, F-D-Phe, difluoro-D-Phe, AcNH-D-Phe, NO2-D-Phe, dinitro-D-Phe, Br-D-Phe, dibromo-D-Phe, CH3-S-D-Phe, OCH3-D-Phe or CH3-D-Phe; R3 is D-Trp or B-D-NAL; R4 is a D-isomer amino acid and preferably B-D-NAL; R5 is Leu or N< alpha >Me-Leu; and R6 is Gly-NH2 or NHCH2CH3; provided however that either R3 or R4 is B-D-NAL.
Patent IE-830850-L (IE)
Title: In vitro preparation of urokinase
IPC: C12N/
Filed: 1983-04-14
Abstract: Novel derivatives of the human protein urokinase are disclosed together with methods of making them using recombinant DNA technology.
Patent FI-832342-L (FI)
Inventor: DE NORA VITTORIO
IPC: C25B1/46
Filed: 1983-06-27
Abstract: A narrow gap electrolysis cell has anode and cathode compartments (10, 11) divided by an ionically-permeable separator (12), such as an ion-exchange membrane or a fibrous diaphragm, and a current feeder grid (18, 19) in electrical contact with a surface-activated particulate electrocatalytic material (14, 15) carried on a face of the separator (12). The particulate material has cores of a corrosion-resistant material preferably valve metal particles or sponge, or compounds thereof, as well as asbestos fibres and fibres of ion-exchange copolymeric perfluorocarbons, coated with a platinum-group metal catalyst in metal or oxide form. The surface-activated particles may be at least partly carried by a flexible electronically conductive foil (16, 17) between the current feeder grid (18, 19) and the separator (12).
Patent FI-844659-L (FI)
Inventor: FUMEI GIANCARLO JOHN
IPC: G09F3/10
Filed: 1984-11-28
Abstract: The present invention provides, without the drawbacks accompanied by the use of hot melt adhesives, a labelled container (8), the label (10), on its underside (22) that is adjacent the container (8) when applied, being provided with a finite area (65) on its leading edge (25) and a finite area (66) on its trailing edge (27), by applying thereto a solvent for the polymer in each of the finite areas (65, 66), the finite areas comprising a viscous tacky solution of the polymer in the solvent, the solidifying solution being sufficient to tack and bond the label (10) to the container (8) during wrapping. After the label (10) is wrapped around the container (8), the bond between the container and label becomes weaker as the solidifying solution hardens so that later the label can be easily and cleanly stripped from the container for recycling. The label can be a coextruded plastics label having a solid polymer layer (15) that is printable and a foam polymer layer (22), the finite areas being on the foam layer.
Patent IE-36890-L (IE)
Title: Yarn storing device
IPC: D03D47/36
Filed: 1972-08-15
Abstract: 1402177 Yarn storage feeder WESCO INDUSTRIES CORP 16 Aug 1972 [28 Sept 1971 21 Dec 1971] 38275/72 Headings DIC and D1E In a yarn storage feeder the yarn is wound on the sloping bottom end 24 of a stationary drum 16 by a flier 30 and is taken off upwardly and then passed down through the centre of the drum and through a supporting tube 14 to knitting, weaving or spooling apparatus. When sufficient yarn has been built up on the drum to press a lever 52 inwardly, a switch 58, 60 opens and a magnetic clutch 46 disengages the drive to the rotating guide. A variable resistor (76, Fig. 5 not shown) may be included in the electrical circuit to delay the disengagement. In a modification a photo electric cell may monitor the quantity of yarn on the drum. In a modification for positive feeding Fig. 10 the yarn is taken off the drum through a second guide 92 rotating at the same speed as the winding-on flier 30.
[GB1402177A]
Patent IE-36686-L (IE)
Title: Cigarette lighter
IPC: F23Q2/167
Filed: 1972-08-17
Abstract: 1334913 Cigarette lighters RONSON PRODUCTS Ltd 10 Aug 1972 [9 Sept 1971] 42216/71 Heading F4F A gas-fuelled cigarette lighter has a flam<SP>e</SP> height adjuster which is controlled by an arm 13 fixed to it and having a projecting end 14, the end extending behind a slot 15 in the ignition actuating lever 3 when the lever is inoperative so that accidental movement of the adjuster is prevented. When the actuating lever 3 is moved to operating position, the end 14 of the arm 13 passes through the slot 15 and is accessible for adjustment of the flame. In an alternative construction the actuating lever 3 (Figs. 4 to 6, not shown) lies along the top of the lighter perpendicular to the burner axis and the operating arm 13 of the adjuster is cranked. The lever 3 is biased (e.g. by a spring) to inoperative position.
[GB1334913A]
Patent IE-841297-L (IE)
Title: Aryloxycycloalkanolaminoalkylene aryl ketones.
IPC: C07D409/12
Filed: 1984-05-24
Abstract: This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.
[EP0127143A2]
Patent IE-781347-L (IE)
Title: Filling flexible containers
IPC: B65B43/54
Filed: 1978-07-04
Abstract: Apparatus for and method of filling flexible containers, each having a spout adapted to be closed by a separable cap, characterized in that the containers are connected together seriatim in a continuous row and are fed automatically one after another to a filling and capping station, rather than being hand fed one at a time to the station. This results in increased speed of operation and decreased labor costs. In one embodiment the containers are moved seriatim to the filling station by an intermittently operated conveyor. In another embodiment the weight of the filled containers pulls succeeding empty containers to the filling and capping station. At the station, between the filling and capping steps, the container is manipulated so as to seal off the spout and prevent entry of foreign matter to the container during the time between removal of the filling nozzle from the spout and application of the cap to the filled container.
[US4120134A]
Patent IE-32998-L (IE)
Title: Bonding metal to rubber
IPC: C08J5/10
Filed: 1968-11-22
Abstract: 1,223,693. Rubber-to-metal bonding. DUNLOP CO. Ltd. 25 Nov., 1968 [2 Dec., 1967], No. 54934/67. Heading C3E. A metal element is bonded to a sulphurvulcanizable rubber by assembling the metal in contact with a cobalt-free composition comprising the rubber, sulphur in an amount of 3À5 to 7À0 parts by weight per 100 parts by weight of rubber, and a delayed action accelerator of the sulphenamide type, and vulcanizing the assembly. The metal is preferably brassplated steel but steel and zinc are also specified.
[GB1223693A]
Patent IE-851521-L (IE)
Title: Oxazinobenzothiazines and oxazinothienothiazines
IPC: C07D513/04
Filed: 1985-06-19
Abstract: Compounds of the formula <IMAGE> +TR <IMAGE> or a pharmaceutically acceptable acid addition salt thereof wherein R is 2-pyridyl, 6-chloro-2-pyridyl, 6-methyl-2-pyridyl or 5-methylisoxazol-3-yl; useful as prodrug forms of the corresponding known oxicam antiinflammatory and analgesic agents, piroxicam, the corresponding 6-chloro-2-pyridyl and 6-methyl-2-pyridylcarboxamides, isoxicam and tenoxicam; methods for their use, pharmaceutical compositions containing them and a process for their preparation.
[US4656265A]
Patent IE-39633-L (IE)
Title: Pressure-sensitive polyurethane adhesive
IPC: C09J7/38
Filed: 1974-07-22
Abstract: 1425500 Polyurethane adhesive ADHESIVE TAPES Ltd 15 July 1974 [20 July 1973] 34807/73 Heading C3R A pressure-sensitive adhesive comprises a partially cross-linked polyurethane of chain length <130 atoms, e.g. 38-125 atoms, formed by reacting polyol(s) terminated with primary and/or secondary OH groups, and an organic polyisocyanate in
Patent IE-43495-L (IE)
Title: Tubes from deformable foam
IPC: B26D3/16
Filed: 1976-07-19
Abstract: In the process a strip (2) of a thermoplastic foam is, before forming, heated on its subsequent tube inside and, after forming and welding of the abutting seam, heated briefly on the outside to the thermoelastic or thermoplastic state and subsequently cooled. As a result, the tubes are dimensionally stable and stress-free. The continuously fed strip (2) is conveyed by means of an endless circulating belt (8) which has a rough surface and conveys the strip (2) through a first heating device (7), a forming funnel (10), a cooled forming tube (14), a welding device (19), a pressing device (20), a second heating device (24) and a cooling device (27). The tubes are suitable in particular for insulation purposes in sanitary installations. <IMAGE>
[GB1514369A]
Patent IE-791604-L (IE)
Title: Steam iron control valve
IPC: D06F75/18
Filed: 1979-08-21
Abstract: In a conventional iron an improvement is provided in the mode valve subassembly that includes a molded cup-shaped valve housing with an upright closed peripherally extending side wall with a pair of spaced stops, the side wall enclosing a flat bottom wall all mounted within the handle.
[US4170835A]
Patent IE-45365-L (IE)
Title: N-(6-CHLORONICOTINOYL)-d,l-HOMOCYSTEINE THIOLACTONE
IPC: C07D309/30
Filed: 1977-08-05
Abstract: N-6-chloronicotinoyl-d,l-homocysteine thiolactone of the formula <IMAGE> (1) and method for its preparation are described. The compound has antilipolytic activity and is useful in compositions for treatment of conditions of elevated free fatty acid and triglyceride plasma levels.
[US4167572A]