baber/WOPTO huggingface dataset:
Patent IL-144641-A0 (IL)
Title: Phenylalaninol derivatives
IPC: A61K31/455
Filed: 2000-02-12
Abstract: New Phenylalaninol derivatives (I). Phenylalaninol derivatives of formula (I) are new: [Image] X : a benzamide group of formula (i), a heterocyclyl-amide group of formula (ii) or an imidazolin-3-yl-4-one group of formula (iii): [Image] R 15halo, NO 2, CN, lower alkylsulfonyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, lower alkylaminosulfonyl, lower perfluoroalkyl, lower alkylthio, lower hydroxyalkyl, alkoxy-lower alkyl, alkylthio-lower alkyl, alkylsulfinyl-lower alkyl, alkylsulfonyl-lower alkyl, lower alkylsulfinyl, lower alkanoyl, aroyl, aryl or aryloxy; R 16H, halo, NO 2, CN, lower alkyl, OH lower perfluoroalkyl or lower alkylthio; Het : 5-6 membered heteroaryl containing 1-2 N, O or S; or 9-10 membered bicyclic heteroaryl containing 1-4 O, S or N; R 30H or lower alkyl; p : 0-1; R 18aryl or heteroaryl; R 19optionally substituted lower alkyl, aryl, heteroaryl, aralkyl or heteroaralkyl; R 20lower alkanoyl or aroyl; Y : a group of formula (iv) or (v) or a 5-6 membered heteroaryl, bonded via C and containing 1-3 O, N or S and optionally substituted by 1-2 lower alkyl, cycloalkyl, halo, CN, perfluoroalkyl or aryl, provided that at least one of the substituents is adjacent to the bonding C; [Image] a : an optional double bond; R 22, R 23H, lower alkyl, lower alkoxy, lower cycloalkyl, aryl aralkyl, NO 2, CN, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkanoyl, halo or perfluoro lower alkyl; provided that at least one is not H; R 24H, lower alkyl, lower alkoxy, aryl, NO 2, CN, lower alkylsulfony or halo; R 25lower alkyl, lower alkenyl (optionally fluorinated) or R 26(CH 2) e; R 26aryl, heteroaryl, N 3, CN, OH, lower alkoxy. lower alkoxycarbonyl, lower alkanoyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfinyl, perfluoro-lower alkanoyl, NO 2 or NR 28R 29; R 28H or lower alkyl; R 29H, lower alkyl, lower alkoxycarbonyl, lower alkanoyl, aroyl, perfluoro lower alkanoylamino, lower alkylsulfonyl, lower alkylaminocarbonyl or arylaminocarbonyl; or R 28 + R 294-6 membered carbocyclic ring optionally containing 1 O, N or S and optionally substituted on C by lower alkyl or halo; Q : (CH 2) fO, (CH 2) fS, (CH 2) fN(R 27), (CH 2) f or a bond; R 27H, lower alkyl, aryl, lower alkanoyl, aroyl or lower alkoxycarbonyl; e : 0-4; and f : 1-3. An independent claim is included for preparation of (I). ACTIVITY : Antirheumatic; antiarthritic; antiasthmatic; antiinflammatory; neuroprotective. MECHANISM OF ACTION : (I) inhibit the binding of vascular cell adhesion molecule-1 (VCAM1) and fibronectin to the integrin VLA-4 (not defined) on circulating lymphocytes, eosinophils, basophils and monocytes.
Patent IL-145011-A0 (IL)
Title: Electronically and mechanically-operated ignition delay for cartridge-type pyrotechnic decoy flare ammunition
IPC: F42B5/15
Filed: 2000-01-24
Abstract: The invention relates to an electronically and mechanically-operated ignition delay which is used in cartridge-type pyrotechnic decoy flare ammunition. Said ignition delay comprises a cylindrical sleeve (10), containing an ignition device (1) in the base, a propellant (2) for expelling the inflammable active material (8) and devices (9) for delaying the ignition of the active material. The electric ignition device of the propellant charge is galvanically connected to a capacitor element (3) which is fixed in the propulsion reflector (4). Said capacitor element is galvanically connected to a mechanical switch-on element (7) in the active material, whereby said mechanical switch-on element is, in turn, galvanically connected to an electric ignition unit in the active material. The switch-on process is thus triggered by the relative movement of the active material as it travels along the sleeve axis away from the propulsion reflector.
Patent IL-150842-A0 (IL)
Title: 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
IPC: C07D495/04
Filed: 2001-02-21
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of general formula (B. geometrical isomers, enantiomers, diastereoisomers, mixtures of each of these and pharmaceutically acceptable salts thereof. whereinR<sup>1</sup> is methyl,R<sup>2</sup> and R<sup>4</sup> are hydrogen.R<sup>3</sup> is alkyl or haloalkenyl, andX is -COOH. -COOMe or -COOEt.
Patent IL-151695-A0 (IL)
Title: Substituted beta-carbolines with ikb-kinase inhibiting activity
IPC: A61P31/06
Filed: 2001-02-28
Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of IkappaB kinase is involved.
Patent IL-160872-A0 (IL)
Title: Pyrimidinones as melanin concentrating hormone receptor 1
IPC: A61K31/517
Filed: 2002-10-15
Abstract: The invention thus provides compounds of formula (I), a salt, or solvate thereof.
Patent IL-179206-A0 (IL)
Title: Pyrrolylpyrimidine derivatives and pharmaceutical compositions containing the same
IPC: C07D403/04
Filed: 2006-11-13
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Patent IL-191690-A0 (IL)
Title: Therapy of malignant neoplasias
Filed: 2008-05-25
Abstract: The present invention provides a 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine for the preparation of a pharmaceutical composition for the treatment of malignant neoplasia. Moreover, the invention provides a method for the treatment of malignant neoplasia, the method comprising the steps of administering 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine to a subject in need thereof and a pharmaceutical composition comprising 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine.
Patent RO-129415-A0 (RO)
Title: Modular floating livewell
Inventor: RUSU IULIUS LIVIU
IPC: A01K63/00
Filed: 2013-10-04
Abstract: The invention relates to a livewell to be employed in aquaculture for the intensive growth of fish under safety conditions, in ponds and sea medium. According to the invention, the livewell comprises four elements () of increased floatability having the function of access roads, provided at the ends with some hinges () for coupling them to four connection platforms () forming a square wherein a net enclosure () is mounted, where the floating elements () comprise two polyethylene floats () stiffened to each other by a spacer system () allowing a flooring () to be mounted at the upper part, by means of some components (), for circulation purposes.
Patent ZW-8785-A1 (ZW)
Title: Containers
Inventor: PERIGO JOHN ALFRED
IPC: B21D51/30
Filed: 1985-05-14
Abstract: A packaging container is closed by using a double seam 152 to secure over the container body 70 a cover 74 of smaller diameter than is usual, creating a radial space 104 around the cover chuck wall 122 into which the body sidewall 72 is deformed to form a neck 76. The cover is initially placed on the body to form a sealable interface 142 therebetween, this interface being preserved throughout the seaming process. The body and/or the cover may be of plastics or metal or a laminated material. In an aseptic packaging process, a primary seal is created at the interface 142 under sterile conditions, seaming subsequently being carried out under non-sterile conditions.
Patent IE-910882-A1 (IE)
Title: Use of spiperone as an immunosuppressant and¹anti-inflammatory agent
IPC: A61K31/445
Filed: 1991-03-15
Abstract: A method for suppressing an immune response in a mammal by treating the mammal with an effective amount of spiperone derivative that is without significant neuroleptic effect due to decreased binding to serotonin and/or dopamine receptors as compared with unmodified or uncomplexed spiperone, or due to topical application which maximizes local immunosuppression while limiting systemic absorption and neuroleptic effects. The spiperone derivatives are capable of inhibiting classic contact hypersensitivity reactions.
Patent LU-86340-A1 (LU)
Title: Charging installation for blast furnace - with symmetrically fed rotating chute
IPC: F27B1/20
Filed: 1986-03-04
Abstract: A blast furnace is charged by rotating or swinging chute below a central hopper outlet, regulated by a measuring valve, symmetrical about the furnace axis. Above the hopper is at least one feed lock, with airtight closures above and below, and a measuring valve to control flow into the hopper. The lock valve is opened first until a blockage develops in the hopper, then the hopper valve to feed charge to the chute. Lock and hopper are continually weighed during charging, and the control valves operated to ensure that the rate of flow out of the hopper is never greater than that out of the lock.
Patent MA-19309-A1 (MA)
IPC: C07K5/02
Filed: 1981-10-20
Abstract: Disclosed are novel carboxyalkyl dipeptides which are useful as inhibitors of angiotensinconverting enzyme and as antihypertensive agents, having the formula 
<CHEM>
 and the pharmaceuticallv acceptable salts thereof, wherein R and R<6> are for example hydroxy, lower alkoxy or aryllower-4 alkoxy; R<1> is for example hydrogen, alkyl, lower alkoxy or aryloxy; R<2> and R<7> are the same or different and are hydrogen or lower alkyl; R<3> is for example lower alkyl or phenyl lower alkyl; R<4> and R<5> are selected from hydrogen, lower alkyl and Z, or R<4> and R<5> taken together form a group represented by Q, U, V, Y, D or E wherein 
<CHEM>
 wherein X<1> and X<2> independent of each other are O, S or CH2, R<8> and R<9> independent of each other are lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl having 3 to 8 carbon atoms, hydroxy lower alkyl or -(CH2)nAr, wherein n is 0, 1. 2 or 3 or R<8> and R<9> taken together form a bridge W, wherein W is a single bond or a methylene bridge or a substituted methylene bridge when at least one of X<1> and X<2> is methylene, or W is an alkylene or substituted alkylene bridge having 2 or 3 carbon atoms; with the proviso that at least one of R<4> and R<5> is Z; 
<CHEM>
 wherein L is O or S.
 The compounds can be prepared according to known methods such as for example by condensation of an aminoacid XXI with an aminoacid XVII 
<CHEM>
Patent MA-38394-A1 (MA)
Title: Dérivés pyridine utilisés comme inhibiteurs de la kinase réarrangée au cours de la transfection (ret)
Inventor: CHEUNG MUI
IPC: C07D413/12
Filed: 2014-03-14
Abstract: La présente invention concerne de nouveaux composés qui sont des inhibiteurs de la kinase réarrangée au cours de la transfection (ret), des compositions pharmaceutiques contenant ceux-ci, des procédés pour leur préparation, et leur utilisation en thérapie, seuls ou en association, pour la normalisation de la sensibilité gastrointestinale, la motilité et/ou la sécrétion et/ou des troubles ou maladies abdominales et/ou dans le traitement de maladies associées à un dysfonctionnement de la ret ou des maladies dans lesquelles une modulation de l'activité de la ret peut avoir un avantage thérapeutique comprenant non exclusivement l'ensemble des classifications du syndrome côlon irritable (ibs) notamment l'ibs à diarrhée prédominante, à constipation prédominante ou à alternance de diarrhée et de constipation, à ballonnement fonctionnel, à constipation fonctionnelle, à diarrhée fonctionnelle, un trouble fonctionnel intestinal non spécifié, un syndrome de douleur abdominale fonctionnelle, une constipation idiopathique chronique, des troubles œsophagiques fonctionnels, des troubles gastroduodénaux fonctionnels, une douleur anorectale fonctionnelle, une maladie abdominale inflammatoire, des maladies prolifératives telles qu'un cancer bronchopulmonaire non à petites cellules, un carcinome hépatocellulaire, un cancer colorectal, un cancer médullaire de la thyroïde, un cancer folliculaire de la thyroïde, un cancer anaplasique de la thyroide, un cancer papillaire de la thyroïde, des tumeurs cérébrales, un cancer de la cavité péritonéale, des tumeurs solides, un autre cancer pulmonaire, un cancer de la tête et du cou, des gliomes, des neuroblastomes, le syndrome de von hippel-lindau et des tumeurs du rein, un cancer du sein, un cancer de la trompe de fallope, un cancer de l'ovaire, un cancer à cellules transitionnelles, un cancer de la prostate, un cancer de l'œsophage et de la jonction gastro-œsophagienne, un cancer des voies biliaires, un adénocarcinome, et toute malignité présentant une activité ret kinase accrue.
Patent MA-39114-A1 (MA)
Title: Frein à disque de véhicule automobile à jeu transversal réduit entre colonnettes et alésages
Inventor: GAYE ANDRÉ
IPC: F16D65/00
Filed: 2016-06-15
Abstract: L'invention se rapporte à un frein à disque de véhicule automobile comportant une chape (12) qui comporte deux alésages étagés d'axes parallèles, dont chacun comporte au moins un premier tronçon (28, 30), un étrier (10) qui est monté coulissant axialement par rapport à la chape (12) par l'intermédiaire de deux colonnettes (16, 18) d'axes (a,b) parallèles solidaires de l'étrier (10) et comportant chacune au moins un tronçon (24, 26) de guidage qui est monté coulissant, avec un jeu radial, dans l'alésage étagé (29, 31) de la chape (12), frein dans lequel une surface externe cylindrique de guidage du tronçon (24, 26) de guidage en coulissement de chaque colonnette (16, 18) comporte au moins deux portions axiales (64) opposées, s'étendant angulairement autour de l'axe (a, b) de chaque colonnette (16, 18) selon un angle inférieur à 90°, un plan axial médian de ces deux portions (64) étant parallèle à un plan passant par les axes (a, b) des deux colonnettes (16, 18).
Patent MA-39315-A1 (MA)
Title: Dérivés de pyridazine à utiliser dans la prévention ou le traitement d'un trouble ataxique
Inventor: ALMOND SARAH
IPC: A61P25/14
Filed: 2015-03-06
Abstract: La présente invention concerne des composés de formule (i) et des sels pharmaceutiquement acceptables de ceux-ci, dans la formule (i), r1 et r2 étant tels que définis dans la description, et sont destinés à être utilisés dans la prévention ou le traitement d'un trouble ataxique.
Patent UY-28066-A1 (UY)
Inventor: BURI MATTHIAS
IPC: C09D7/45
Filed: 2003-11-06
Abstract: The use of a weakly ionic, water-soluble copolymer (A) is claimed as brightness activator at any angle of vision (i.e. at an angle of 20-85 (preferably 45-75) [deg]), where (A) is derived from at least one ethylenically unsaturated monomer (I) on which at least one alkoxy- or hydroxy-polyalkylene glycol function is grafted. Independent claims are included for: (a) an agent for activating brightness as above, comprising at least one copolymer (A); (b) methods for dispersing or milling minerals (B) in aqueous suspension, using (A); (c) aqueous suspensions of dispersed or milled (B), which contain (A); (d) a method for producing bulk coating slurries, using (A); and (e) coating slurries, which contain (A).
Patent ES-149070-A1 (ES)
Title: APARATO PARA MEDIR LiQUIDOS
Filed: 1941-08-21
Abstract: Aparato para medir líquidoscaracterizado por el hecho de que funciona bajo la presión de un fluido (líquido o gas) que acelera las operaciones de llene y vaciado de los compartimentos medidoresactuando directamente sobre el líquido objeto de medición o bien indirectamente por interposición de membranas elásticaspistón o campanaen ambos casosla velocidad del líquido ya sea este fluido o viscosoes aumentadaacelerando la expulsión del líquido después de medido.
Patent ES-174981-A1 (ES)
Title: PERFECCIONAMIENTOS EN CARROCERiAS DE AUTOMoVILES
Filed: 1946-09-17
Abstract: Perfeccionamientos en carrocerías de automóviles que incluyen una carrocería de automovil que tiene un alojamiento para las ruedas que comprende un tablero exterior que forma parte integrante del tablero lateral un tablero interior de revestimiento prácticamente paralelo al tablero lateral citado y que deja una cámara de aire entre dichos tableros; una abertura a través de dichos tableros exterior e interior y estos se acoplan entre sí y se unen inmediatamente junto a la periferia de la abertura citada.
Patent ES-179606-A1 (ES)
Title: UNAS MEJORAS Y PERFECCIONAMIENTOS INTRODUCIDOS EN LA FABRICACIoN DE TACOS RECIBIDORES DE LANZADERAS PARA TELARES
Filed: 1947-09-04
Abstract: Mejoras y perfeccionamientos introducidos en la fabricación de tacos recibidores de lanzaderas para telares, que se caracterizan porque el taco se compone, normalmente de cuatro piezas independientes que son: el cuerpo del taco, la pieza recibidora del golpe de la lanzadera, la pieza que forma el cojinete de deslizamiento, y la pieza que sirve para la sujeción del taco con la correa impulsora, la cual pieza puede también si se quiere hacerla no independiente del cuerpo del taco, sino por ir tallada en el mismo material de éste.
Patent ES-180301-A1 (ES)
Title: Mejoras en o relativas a condesadores electricos
IPC: H01G2/12
Filed: 1947-10-30
Abstract: Mejoras en condensadores eléctricos del tipo tubular en los que láminas intercaladas de electrodo y dieléctrico se enrollan alrededor de un mandril de material aislante para formar una unidad de condensador y se coloca alrededor de dicha unidad una cubierta de lámina metálica estando los extremos de dicha lámina unidos metálicamente a superficies metalizadas en dicho mandril proveyendo con ello extremos sellados herméticamente y cubierta hermética para dicho condensador.
Patent ES-181831-A1 (ES)
Title: Mejoras en microteléfonos
IPC: H04M1/06
Filed: 1948-01-24
Abstract: Mejoras en microteléfonos que tienen un elemento que lleva unidades transmisora y receptora y un soporte para recibir el microteléfono cuando no está en uso, caracterizado pro el hecho de que se proporcionan dispositivos de gobierno de contacto dentro del referido elemento, para gobernar los circuitos de las referidas unidades, teniendo el soporte por lo menos una saliente coincidente con una abertura correspondiente en el referido elemento, para mantener a los dispositivos de gobierno en posición de desconexión.
Patent ES-197275-A1 (ES)
Title: UNA BOMBA DE INYECCIoN DE COMBUSTIBLE
IPC: F02D1/02
Filed: 1951-04-04
Abstract: Una bomba de inyección de combustible del tipo especificado en esta Memoria en la cual una bomba de alimentación del combustible está dispuesta dentro de la caja en esencial centralmente al anillo de émbolos de bomba y se disponen medios para hacer funcionar la bomba de alimentación desde la leva frontal común que acciona estos émbolos.
Patent ES-255281-A1 (ES)
Title: A process for protecting synthetic fibres from ultra-violet rays
IPC: D06M13/35
Filed: 1960-01-14
Abstract: Fully synthetic fibres, e.g. polyamide, polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyacrylonitrile and polyester fibres, are protected from ultra-violet rays by fixing on them fron an aqueous bath a colourless or at most slightly coloured compound of the formula:- <FORM:0879144/IV(c)/1> in which R1 and R2 represent aromatic residues of the benzene series and two vicinal carbon atoms of the residue R2 form members of the triazole ring and the residue R1 contains a free hydroxyl group, an etherified hydroxyl group or an acyloxy group in the ortho-position relatively to the bond with the triazole ring. The residues R1 and/or R2 may be further substituted by halogen atoms, branched or unbranched alkyl groups, trifluoromethyl, hydroxyalkyl or aralkyl groups, phenyl groups which themselves may be substituted, carboxylic acid, carboxylic acid ester, sulphonic acid, sulphonamide, alkysulphonyl, arylsulphonyl or aralkylsulphonyl groups, primary, secondary or tertiary amino groups, free hydroxyl groups or alkoxy or acyloxy groups. The triazole compound may be dissolved or dispersed in the aqueous bath, which may be acid to weakly alkaline, if necessary with the aid of an anionic or non-ionic dispersing agent, e.g. an addition product of ethylene oxide with a higher alcohol, or the triazole may be dissolved in an organic solvent which is miscible or soluble in water, e.g. methanol, ethanol or acetone, and the solution then poured into water, or dispersion may be effected, by the use of a colloid mill. The fibres, which may be in the form of loose fibres, hanks or woven or knitted fabrics, may be treated at 80 DEG -120 DEG C. for 20-120 minutes to fix 0,1-5% by weight of the triazole compound, based on the weight of the fibres. The treatment may be combined with treatment to impart an antistatic finish or soft handle or with dyeing.
Patent ES-265331-A1 (ES)
Title: Substituted benzamides
IPC: C07D/
Filed: 1961-03-02
Abstract: The invention comprises compounds of the formula <FORM:0897989/IV (b)/1> (wherein R and R1 are alkyl radicals each containing at most 8 carbon atoms) and their preparation by heating p-hydroxy-benzylamine with 3,4,5-trimethoxybenzoyl chloride in an inert anhydrous organic solvent in the presence of a tertiary amine, heating an alkali metal salt of the precipitated N-(p-hydroxybenzyl)-3,4,5-trimethoxybenzamide at 65 DEG C. to 70 DEG C. with an N-chloroethyl-3,3-dialkyl-azetidine in an inert anhydrous organic solvent, evaporating the mixture to dryness, taking up the residue in an organic solvent, evaporating after filtration of the inorganic salt, taking up the residue with diethyl ether and precipitating the product by adding light petroleum. An example is given. N - Chloroethyl - 3, 3 - dialkylazetidines are prepared by reacting 3,3-dialkylazetidines with ethylene oxide to give 3,3-dialkyl-1-(b -hydroxyethyl)-azetidines and reacting these with thionyl chloride. The compounds of the invention, which are stated to be antihistaminic and antiemetic agents, may be formulated as pharmaceutical compositions with solid or liquid carriers or diluents.
Patent ES-293653-A1 (ES)
Title: Apparatus and method for starting a vapor generating power plant
IPC: F01K3/22
Filed: 1963-11-19
Abstract: A method for starting a forced-flow oncethrough vapour generator, having means for recirculating heated fluid through the vapour generating section, comprises initially maintaining a liquid level in a primary superheater and thereby obtaining low pressure vapour. In starting a vapour generator comprising economizer 20, vapour generating tubes 24, boiler throttling valves 56, 57, convection superheater 32 and finishing superheater 36 arranged in series together with turbine 40, condenser 14, feed pump 12 and feed valve 18 and having a recirculating circuit 46 containing valve 52, a mixing vessel 48 and a pump 50 for recirculating fluid through the tubes 24, fluid is first pumped through the economizer 20 and tubes 24 and, with valves 56, 57 closed, discharged through a boiler extraction valve 55. When this cleaning operation is completed valve 55 is closed or set to open at a predetermined high pressure, the furnace is fired and when a given pressure is reached valve 18 is closed and liquid is recirculated through tubes 24 to maintain a minimum safe velocity through them. When a given temperature, determined at a point such as 72, is reached, valve 57 is gradually opened by an actuator 62 permitting fluid to flow into superheater 32 which is maintained at a low pressure by a relief valve 75. Some of the fluid vaporizes, cooling the final superheater 36 whilst the remainder establishes a liquid level 58. When a suitable pressure and temperature has been reached as indicated by devices 74, 76, a turbine flow control valve 42 is opened permitting vapour to commence heating and rolling the turbine. Valve 57 is then controlled, to maintain the level 58, by a pressure differential indicating device 60 connected hydraulically or electrically to pressure sensing means 64, 66 until as the temperature in the vapour generating portion rises and normal operating conditions are approached the liquid level 58 falls until no liquid remains in the superheater 32 and the pressure drop across valves 56, 57 as indicated by devices 73 becomes negligible when these valves are fully opened.