baber/WOPTO huggingface dataset:
Patent JP-2991499-B2 (JP)
IPC: A61K35/14
Filed: 1994-09-02
Granted: 1999-12-20
Abstract: Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.
Patent JP-H0737380-B2 (JP)
IPC: A61P31/12
Filed: 1991-05-24
Abstract: The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.
Patent JP-3117459-B2 (JP)
IPC: G01N33/533
Filed: 1991-07-12
Granted: 2000-12-11
Abstract: The invention relates to a method of amplifying the emission signal of a luminescent compound in a luminescent assay, and to its use in a luminescent method of detecting and/or determining an analyte in a medium in which it may be present.
Patent JP-3911545-B2 (JP)
IPC: C07D211/60
Filed: 1995-10-23
Granted: 2007-05-09
Abstract: PCT No. PCT/GB95/02513 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Oct. 23, 1995 PCT Pub. No. WO96/12699 PCT Pub. Date May 2, 1996Levobupivacaine or an analogue thereof is prepared by reaction with a tartaric acid resolving agent in a solvent, in the presence of water and/or less 0.5 equivalents of the resolving agent.
Patent JP-4484969-B2 (JP)
IPC: A61K47/48
Filed: 1997-11-25
Granted: 2010-06-16
Abstract: The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein. The invention also relates to vaccines and composition for suppressing allergic immune responses to allergens comprising an allergen and all or a portion of a stress protein.
Patent JP-3540317-B2 (JP)
IPC: C07D417/14
Filed: 1994-04-07
Granted: 2004-07-07
Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I:    <IMAGE>  Formula I  wherein X is oxygen, sulfur   <IMAGE>   A is -CH2- or   <IMAGE>   E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Patent JP-3602141-B2 (JP)
IPC: A23K1/16
Filed: 1997-01-31
Granted: 2004-12-15
Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid. 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
Patent JP-4112619-B2 (JP)
IPC: C12N5/00
Filed: 1997-02-17
Granted: 2008-07-02
Abstract: Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation. An outlet tube transfers the enriched fraction to a storage bag and is placed in a position adjacent the periphery of the centrifuge rotor for further separation of the enriched fraction at transferring, during continued centrifugation, the enriched fraction through the outlet tube.
Patent JP-3428657-B2 (JP)
IPC: G06K19/077
Filed: 1997-11-18
Granted: 2003-07-22
Abstract: A chip card module contains, in addition to conductor tracks and a chip carrier, one or more semiconductor chips and, if necessary, a stiffening frame. The semiconductor chip(s) and/or stiffening frame are attached with the aid of an adhesive, with which particles of a defined size are admixed as spacers. The adhesive in preferably a flexible adhesive, and the particles preferably are formed of a deformable material. The invention has the effect that the semiconductor chip(s) and/or stiffening frame are adhesively attached to the underlying surface at a defined, uniform distance. The flexible adhesive and the deformable particles adapt to deformations of the chip card module and thus prevent damage to the adhesively bonded mating surfaces.
Patent JP-4172817-B2 (JP)
IPC: C07D307/79
Filed: 1996-05-20
Granted: 2008-10-29
Abstract: An oxygen-containing heterocyclic compound represented by following Formula (I): <CHEM> wherein R<1> and R<2> independently represent hydrogen, lower alkyl, cyano, -(CH2)n-E-CO-F (wherein E represents a bond, O, or NH; F represents OR<6> or NR<7>R<8>; and n represents an integer of 0 to 4), or the like; R<1> and R<2> are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R<2>, and R<11> or R<13> described below are combined to form a single bond; R<3> represents hydrogen, phenyl, or halogen; R<4> represents hydroxy, lower alkoxy, or the like; A represents -C(R<9>)(R<10>)- or O; B represents O, NR<11>, -C(R<12>)(R<13>)-, or -C(R<14>)(R<15>)-C(R<16>)(R<17>)-; D represents (i) -C(R<18>)(R<19>)-X- (wherein X represents -C(R<21>)(R<22>)-, S, or NR<23>), (ii) -C(R<19a>)=Y- ÄY represents -C(R<24>)-Z- (wherein Z represents CONH, CONHCH2, or a bond), or NÜ, or (iii) a bond; and R<5> represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
Patent PL-162361-B2 (PL)
Title: Multicomponent sanitary appliance
Inventor: CYCHOL JAN K
IPC: E03C1/14
Filed: 1989-06-23
Abstract: Washbasin possessing a basin with a hatch, overflow trough and outlet pipe characterised in that it consists of three plastic elements, a basin (4) possessing, in its upper part, a hatch (5), in its lower part, an outlet pipe (4), and on the perimeter, guides (6) of the casing (2) closing the solid of the washbasin possessing, in its lower part, an opening (9) for a pipe (4), and in its upper part, catches (8), and overflow trough (3) connecting the hatch (5) with a pipe (4), and the space between the basin (1) and the trough (3) and the casing (2) is filled with foamed plastic which binds those components together.<IMAGE>
Patent ES-2197765-B2 (ES)
Title: Maquina de limpieza de boquillas con papel.
Inventor: MOYA GARCIA JOSE JULIO
IPC: B05B15/02
Filed: 2001-08-17
Granted: 2005-03-16
Abstract: La presente invención se refiere a una máquina para la limpieza de boquillas inyectoras, que se montará como una estación más de una máquina cuya finalidad es el pegado de cristales. Esta máquina de limpieza de boquillas, podrá ser fija dentro del conjunto de la máquina o desplazable, dependiendo de que el tipo de boquilla inyectora sea fija o desplazable. La limpieza de esta boquilla se efectúa al penetrar dicha boquilla envuelta en un papel a un cabezal de fijación accionado neumáticamente, efectuando la boquilla una serie de giros, dejando la masilla o material en la banda de papel.
Patent ES-2204278-B2 (ES)
Title: Material para ortesis de compresion con hendiduras arqueadas.
Inventor: CHIANG JACKSON
IPC: B32B25/04
Filed: 2002-04-02
Granted: 2005-01-01
Abstract: Material para órtesis de compresión con hendiduras arqueadas. El presente invento proporciona un material compuesto para uso en la fabricación de órtesis elásticas para soportar una parte del cuerpo con compresión. El material compuesto incluye capas central (110), interior (120) y exterior (130). La capa central tiene en una cara una pluralidad de gargantas (100) que se entrecruzan para definir un diseño de retícula, que funcionan como pasos a lo ancho y a lo largo de la capa, para favorecer la disipación del calor y de la humedad de la parte de cuerpo que se está soportando. Una pluralidad de cortes (150) que se extienden a través de todo el grosor de la capa central y distribuidos por la superficie de la capa, al tiempo que conservan una elasticidad y una densidad suficientes para proporcionar un soporte con compresión adecuado. En una realización del invento, la capa central incluye una pluralidad de hendiduras arqueadas (250) que definen partes de lengüeta (255) que permanecen unidas de forma abisagrada a la capa central.
Patent ES-2317817-B2 (ES)
Title: Sistema estimulador neumatico somatosensorial de sincronizacion manual.
Inventor: MAESTU UNTURBE CEFERINO
IPC: A61B5/055
Filed: 2008-12-30
Granted: 2009-10-23
Abstract: Sistema estimulador neumático somatosensorial de
sincronización manual  con dispositivos de medida que no contienen
trigger que comprende tres  módulos: 
     - Un primer módulo de control que comprende
medios de visualización de  datos y procesamiento de datos de una
secuencia de estimulación que envía  la información al módulo
mecánico a través de un cable de conexión (8). 
     - Un segundo módulo mecánico que comprende: 
     - un compresor (12) de aire conectado a un
filtro regulador (4), y 
     - una caja metálica (11) que recibe la
información del módulo de control  y la envía al módulo aplicador en
forma de presión a través de unas válvulas  conectadas al filtro
regulador (4), 
     - Un tercer módulo aplicador, que comprende un
soporte con al menos dos  conexiones (3a y 3b) a las válvulas del
módulo mecánico, que regulan el  movimiento de extensión y
retracción de un pistón (1).
Patent ES-2562841-B2 (ES)
Title: Dispositivo y método de mejora de terreno blando
Inventor: CASTRO GONZALEZ JORGE
IPC: E02D3/10
Filed: 2015-09-01
Granted: 2016-07-12
Abstract: Elemento hueco (10, 20, 30, 40, 50) configurado para introducir en terreno blando (38, 48, 58), y abierto al menos por su extremo inferior, tal que cuando dicho elemento hueco (10, 20, 30, 40, 50) se introduce en el terreno blando (38, 48, 58) su interior queda relleno de dicho terreno blando (38, 48, 58) existente, y que comprende una geored (11) de forma cilíndrica configurada para permitir la circulación de agua a su través; un geosintético (12) que cubre la superficie exterior de la geored (11) y que realiza una función de filtro, dejando pasar el agua pero no las partículas de terreno blando (38, 48, 58) existente; y al menos un geosintético (13) que cubre la superficie interior de la geored (11) y que realiza una doble función: por un lado deja pasar el agua pero no las partículas de terreno blando (38, 48, 58) -función filtro- y por otro lado dota al elemento hueco (10, 20, 30, 40, 50) de una rigidez radial función resistencia-. Un método de mejora de terreno blando (38, 48, 58), utilizando el elemento hueco (10, 20, 30, 40, 50) definido.
Patent AU-2001263425-B2 (AU)
Title: Silylated polyurethane-urea compositions for use in cosmetic applications
Inventor: LEWANDOWSKI KEVIN M
IPC: A61Q1/12
Filed: 2001-05-24
Granted: 2006-08-10
Abstract: A composition in the form of an aqueous dispersion used in cosmetic applications is provided. The composition comprises at least one polyurethane-urea polymer that is functionalized with at least one hydrolyzed or hydrolyzable silyl group. When the composition is used in hair care, it does not have a reshapable effect.
Patent AU-2001287272-B2 (AU)
Title: Genes involved in intestinal inflammatory diseases and use thereof
Inventor: HUGOT JEAN-PIERRE
IPC: C12Q1/6883
Filed: 2001-03-27
Granted: 2006-09-21
Abstract: The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The invention also concerns methods for diagnosing inflammatory diseases.
Patent AU-2002213980-B2 (AU)
Title: Method for connecting ignitors in an ignition system
Inventor: SCHAFER HEINZ
IPC: F42D1/055
Filed: 2001-09-28
Granted: 2007-04-26
Abstract: The invention relates to an ignition system comprising a plurality of ignition circuits (2, 3, 4, 5). When connecting and logging of a logger occur for ignitors with respect to the bus lines (6, 7, 8, 9) said logger being connected to a blaster, errors can occur. Connection occurs especially in open-cast mining in conditions which initially do not appear damaging, particularly with respect to the insulation of the ignitors and the ignition lines. Errors can occur when data is being transferred, for example by loosing or altering the signal which is to be transferred or by infiltration of a signal from a foreign ignitor. According to the invention, an anlog manager (22) is installed which is in bi-directional contact with the loggers, the blaster and the log data transmitters of the logger which transmit the data from the ignitor to the logger. The anlog manager co-ordinates the logging of the ignitor to a respective bus line (6, 7, 8, 9), in addition to the programming of the ignitors, and verifies if an error free data transfer has taken place.
Patent AU-2002218179-B2 (AU)
Title: Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
Inventor: LANTOS CARLOS P
IPC: C07J71/00
Filed: 2001-09-17
Granted: 2006-11-16
Abstract: A method of preparing 21-hydroxy-6,19-oxidoprogesterone, or an acylated or phosphorlated version thereof.
Patent AU-2002224815-B2 (AU)
Title: A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine
Inventor: KOOLEN MARCUS JOSEPHUS MARIE
IPC: C12R1/93
Filed: 2001-10-30
Granted: 2006-10-12
Abstract: The present invention provides a NDV mutant that is suited as a marker vaccine strain. The NDV mutant is not able to express an immunodominant epitope of the nucleoprotein (NP).
Patent AU-2002226652-B2 (AU)
Title: An anti-atherosclerosis composition containing carotenoids and method for inhibiting LDL oxidation
Inventor: NIR ZOHAR
IPC: A23L33/155
Filed: 2002-01-21
Granted: 2006-09-07
Abstract: An anti-atherosclerosis composition comprising a LDL-oxidation inhibiting effective amount of phytoene, phytofluene or mixtures thereof and a method for inhibiting the progression of atherosclerosis.
Patent AU-2002238795-B2 (AU)
Title: Bacteriophage composition useful in treating food products to prevent bacterial contamination
Inventor: GEMMELL JACK
IPC: A61K35/74
Filed: 2001-11-15
Granted: 2006-10-26
Abstract: The present invention is directed to novel bacteriophage compositions useful in treating food products to prevent bacterial contamination.
Patent AU-2002246816-B2 (AU)
Title: Annulus repair systems and methods
Inventor: TRIEU HAI H
IPC: A61F2/00
Filed: 2001-10-26
Granted: 2006-03-09
Abstract: Systems and methods for repairing annulus defects include scaffold ( 30 ), attachment members ( 40 ), and anchors ( 20 ). The scaffold ( 30 ) acts as a plug to substantially fill the annulus defect. The anchors ( 20 ) are secured to tissue adjacent the annulus defect. The attachment member ( 40 ) secures the scaffold ( 30 ) to the anchors ( 2 ). Thus, the systems and methods for repairing annulus defects retain the scaffold within the annulus defect.
Patent AU-2002300712-B2 (AU)
Title: A self-lubricating, non-sealing piston ring for an internal combustion fastener driving tool
Inventor: PORTH CHRIS H
IPC: F02F5/00
Filed: 2002-08-21
Granted: 2004-12-23
Abstract: A non-sealing, lubricating piston ring (15) for lubricating the cylinder wall (11) of a piston housing in a combustion tool is disclosed. The lubricating piston ring (11) is made from a lubricating material such as polytetrofluroethylene (PTFE). The shape of the PTFE ring is designed to optimize the lubricity of the piston housing, while allowing enough friction for the piston (12) to operate properly within the piston housing during reciprocating cycling movement. The PTFE ring (20, 50, 60) may have radial fins (22, 52, 62) extending from an outer surface thereof that are angled to promote ring rotations, such that the ring moves easily along and efficiently lubricates the inner cylinder wall of the piston housing. The PTFE ring does not form a seal between the piston and the housing. Instead, the PTFE ring is positioned above or below a sealing ring, (13, 14) such as a steel piston ring which forms the seal between the piston and the piston housing.
Patent AU-2002314967-B2 (AU)
Title: Use of methylnaltrexone to treat immune suppression
Inventor: MOSS JONATHAN
IPC: A61P35/00
Filed: 2002-06-05
Granted: 2007-09-20
Abstract: Methods for treating opioid-induced immune suppression with peripheral opioid antagonists are provided. In one embodiment, the method involves administering methylnaltrexone. Pharmaceutical compositions comprising an opioid, an opioid antagonist, and a pharmaceutical agent are also provided.
Patent AU-2002326375-B2 (AU)
Title: Facially amphiphilic polymers as anti-infective agents
Inventor: LIU DAHUI
IPC: C08G69/26
Filed: 2002-03-07
Granted: 2006-12-21
Abstract: Facially amphiphilic polyphenylene and heteroarylene polymers and articles made there from having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polymers to a solid support. Utility as a contact disinfectant is disclosed.
Patent AU-2002346953-B2 (AU)
Title: Protective garment
Inventor: BOTTGER CHRISTIAN KURT
IPC: A41D31/00
Filed: 2002-10-19
Granted: 2007-11-22
Abstract: Protective clothing comprises at least one protective material including an array of one or more superposed layers of woven fabric, wherein each fabric layer is flexible and includes at least one fabric, made of yarns having a strength of at least 900 MPa, that is joined to at least one polymer film, and wherein the protective material has an outer surface facing the side of attack and an inner surface facing away from the side of attack, wherein the protective material also has at least one layer of felt, placed in every case on one of the fabric layers.
Patent AU-2003210320-B2 (AU)
Title: Device for hot dip coating metal strands
Inventor: JEPSEN OLAF NORMAN
IPC: C23C2/24
Filed: 2003-02-20
Granted: 2008-07-31
Abstract: The invention relates to a device for hot dip coating metal strand ( 1 ), particularly strip steel, in which the metal strand ( 1 ) can be vertically guided through a reservoir ( 3 ), which accommodates the molten coating metal ( 2 ), and though a guide channel ( 4 ) connected upstream therefrom. An electromagnetic inductor ( 5 ) is mounted in the area of the guide channel ( 4 ) and in order to retain the coating metal ( 2 ) inside the reservoir ( 3 ), can induce induction currents in the coating metal ( 2 ) by an electromagnetic traveling field. While interacting with the electromagnetic traveling field, the induction currents exert an electromagnetic force. The inductor ( 5 ) has at least two main coils ( 6 ) that are arranged in succession in movement direction (X) of the metal strand ( 1 ), and has at least two correction coils ( 7 ) for controlling the position of the metal strand ( 1 ) inside the guide channel ( 4 ) in direction (N), which is normal to the surface of the metal strand ( 1 ). These correction coils are also arranged in succession in movement direction (X) of the metal strand ( 1 ). In order to improve the efficiency of the control of the metal strip inside the guide channel, the invention provides that at least a portion of the correction coils ( 7 ), when viewed in movement direction (X) of the metal strand ( 1 ), are arranged so that they are offset with regard to one another perpendicular to movement direction (X) and perpendicular to direction (N) that is normal to the surface of the metal strand ( 1 ).
Patent AU-2003226543-B2 (AU)
Title: Mutation of DNA polymerases from archaeboacteria
Inventor: PEARL LAURENCE
IPC: C12Q1/686
Filed: 2003-04-15
Granted: 2004-11-04
Abstract: The present invention relates to a variant archaeal DNA polymerase having a modified amino acid sequence of a wild-type amino acid sequence, the modified sequence being in the amino-terminal amino acids that comprise a uracil-binding pocket in the wild-type polymerase whereby the variant polymerase has reduced affinity for uracil than the wild-type polymerase. Such variant polymerases may be usefully employed in biological assay systems such as the polymerase chain reaction.
Patent AU-2003241598-B2 (AU)
Title: Radiolabeled compounds and liposomes and their methods of making and using the same
Inventor: GOINS BETH
IPC: C07F5/00
Filed: 2003-05-22
Granted: 2009-11-05
Abstract: The invention, in one aspect, relates to radiolabeled compounds. The invention also relates to radiolabeled liposomes and methods of making and using thereof. The invention also relates to kits for preparing radiolabeled liposomes.