Patent SG-11201809502Y-A (SG)
Title: Processes for preparing phosphorodiamidate morpholino oligomers
Inventor: CAI BAO
IPC: C12N15/113
Filed: 2017-06-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 November 2017 (30.11.2017) WIPO I PCT o 1E1 olo VIII VIII Inoi Holum moimmlummoiml (10) International Publication Number WO 2017/205879 A2 (51) International Patent Classification: A61K 48/00 (2006.01) COIF 9/6533 (2006.01) (21) International Application Number: PCT/US2017/040311 (22) International Filing Date: 30 June 2017 (30.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/340,953 24 May 2016 (24.05.2016) US 62/341,049 24 May 2016 (24.05.2016) US 62/357,153 30 June 2016 (30.06.2016) US 62/357,134 30 June 2016 (30.06.2016) US 62/508,256 18 May 2017 (18.05.2017) US Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with information concerning request for restoration of the right of priority in respect of one or more priority claims (Rules 26bis.3 and 48.2(b)(vii)) (71) Applicant: SAREPTA THERAPEUTICS, INC. [US/US]; 215 First Street, Cambridge, MA 02139 (US). (72) Inventors: CAI, Bao; c/o Sarepta Therapeutics, Inc., 215 First Street, Cambridge, MA 02142 (US). MARTINI, Mitchell; c/o Sarepta Therapeutics, Inc., 215 First Street, Cambridge, MA 02142 (US). THOMAS, Katie; c/o Sarep- ta Therapeutics, Inc., 215 First Street, Cambridge, MA 02142 (US). SHIMABUKU, Ross; c/o Sarepta Therapeu- tics, Inc., 215 First Street, Cambridge, MA 02142 (US). (74) Agent: TRINQUE, Brian, C. et al.; Lathrop & Gage, LLP, 28 State Street, Boston, MA 02109 (US). — (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, • MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 00 O N (54) Title: PROCESSES FOR PREPARING PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS 0 (57) : Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described \" herein may be advantageous to scaling up oligomer synthesis while maintaining overall yield and purity of a synthesized oligomer.