baber/WOPTO huggingface dataset:
Patent CA-2933433-A1 (CA)
Inventor: FRENDEWEY DAVID
IPC: C12N9/22
Filed: 2014-10-15
Abstract: Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided.
Patent CA-2933730-A1 (CA)
Inventor: VERLEYE MARC
IPC: A61P25/00
Filed: 2014-12-17
Abstract: La présente invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, pour une utilisation dans la prévention ou le traitement de déficit de l'attention et/ou de l'hyperactivité chez un individu.
Patent CA-2935734-A1 (CA)
Title: Catheter assemblies having a protective lubricious sleeve
Inventor: O'FLYNN PADRAIG M
IPC: A61M25/00
Filed: 2015-01-08
Abstract: A catheter assembly(lO) includes a protective tip (14) defining an interior chamber (20) between its proximal and distal ends. A protective lubricious sleeve (24) is positioned within the interior chamber. A catheter (12) of the assembly is configured to be advanced proximally into and through the interior chamber to position at least a portion of the catheter within the protective sleeve, with the protective sleeve being retained upon the catheter as at least a proximal portion of the catheter exits the proximal end of the protective tip and is advanced through a body lumen. A second sleeve (106) may be associated with the protective tip and configured to extend distally from the protective tip to remain outside of the body lumen during use and receive a more distal portion of the catheter.
Patent CA-2937834-A1 (CA)
Title: Differential safety valve
Inventor: GAY MICHAEL GLENN
IPC: E21B34/14
Filed: 2015-01-22
Abstract: A valve for limiting differential pressure applied to a downhole tool includes a housing and a movable piston/mandrel assembly therein. In a closed position, drilling mud or other fluid may be communicated through a central bore of the valve to the tool. When the differential pressure between the central bore and the wellbore exceeds a first predetermined value, the piston/mandrel assembly moves from a first position obstructing one or more relief ports to a second position not obstructing them, thereby providing a fluid path from the central bore of the valve to the wellbore bypassing the tool and relieving the differential pressure thereacross. When the differential pressure decreases to less than another preselected value, the piston/mandrel assembly returns to its original position again obstructing the relief ports. A trigger mechanism is provided to allow more precise control and separation of the preselected differential pressure values.
Patent CA-2937901-A1 (CA)
Title: Multi-dose disposable system
Inventor: UBER ARTHUR E III
IPC: A61M36/06
Filed: 2015-02-18
Abstract: A multi-dose disposable fluid delivery system includes at least one fluid container, a multi-use fluid path set, and a plurality of single-use fluid path sets. The at least one fluid container has a connection port configured for fluidly connecting with a first end of the multi-use fluid path set. The second end of the multi-fluid path set is configured for fluidly connecting to a fluid injection apparatus. The plurality of single-use fluid path sets is connected in sequence to define a fluid path extending from a first single-use fluid path set to a last single- use fluid path set. Each of the plurality single-use fluid path sets has a first end and a second end. The first end of the first single-use fluid path set is configured for connecting to a delivery line. The second end of the last single-use fluid path set is configured for connecting to the injection apparatus.
Patent CA-2938327-A1 (CA)
Inventor: BASU SHUBHAYU
IPC: A61B5/296
Filed: 2016-08-08
Abstract: This disclosure is directed to a catheter having a basket-shaped electrode assembly with a high electrode density. The basket-shaped electrode assembly may have a plurality of spines, such as up to twelve, each with a plurality of electrodes, such as up to sixteen. Each spine may have cabling with embedded coiled wires such that each electrode is attached through the sheath to one of the wires.
Patent CA-2938402-A1 (CA)
Title: Normalisation de biomarqueur
Inventor: SULLIVAN BENJAMIN
IPC: G01N33/487
Filed: 2008-04-16
Abstract: Linvention concerne un échantillon de fluide qui est mesuré à laide dun système de mesure de film lacrymal. Le système comprend un dispositif de traitement qui reçoit une pastille déchantillon comprenant une région déchantillon configurée pour contenir un volume daliquote de fluide déchantillon. De plus, le dispositif de traitement est configuré pour effectuer des analyses dosmolarité et dun ou plusieurs biomarqueurs, dans le fluide déchantillon. En outre, lanalyse de biomarqueur comprend la normalisation de valeurs de concentration de biomarqueur.
Patent CA-2943102-A1 (CA)
Inventor: FREI ROBERT
IPC: B65D30/08
Filed: 2016-09-23
Abstract: A reinforced multilayer material includes a mesh material covered on at least one side, and possibly both, by a layer of a resinous film material. The mesh material includes filaments that intersect one another, at least some of the filaments being composite filaments having a carrier portion of a relatively high melting point and a bonding portion of a relatively low melting point, the bonding portion of each composite filament being thermally bonded to other filaments at least some points of intersection. The multilayer material has a mass per unit area of less than 9.0 oz/yd2 and a bursting strength to mass per unit area ratio of at least 9.0 lbs/(oz/yd2), where bursting strength is measured in accordance with ASTM-D37 86. A bag is provided that is made at least in part from a multilayer material having at least some of the characteristics described above.
Patent CA-2944247-A1 (CA)
Inventor: ALDEN J MICHAEL
IPC: F23D14/48
Filed: 2016-10-05
Abstract: The present inventions provide, among other things, tapered burner tubes having raised gas ports and a smooth interior surface free from obstructions. Venturi members and air shutters may also be included.
Patent CA-2945135-A1 (CA)
Inventor: LIDDLE KATHERINE
IPC: A61F5/058
Filed: 2015-04-06
Abstract: A kit and method are presented for making a mending device, such as a splint, for immobilizing a body part, such as a limb. The kit includes a formable material and heating source. The heating source is used to selectively heat the formable material to an elevated material, molding the formable material into a required shape for the mending device and allowing the molded material to cool to room temperature and become hard again. The formable material may be molded on or around and in contact with the desired body part. The heating source may include a chemical composition that is selectively activated, for example by adding water to it.
Patent CA-2948246-A1 (CA)
Inventor: MILLER BRANDON WAYNE
IPC: B64C11/14
Filed: 2016-11-14
Abstract: A gas turbine engine includes a core and a tie shaft. The tie shaft is rotatable about an axial direction of the gas turbine engine by the core of the gas turbine engine. The gas turbine engine additionally includes a modular fan having a plurality of fan blades and a frame. The plurality fan blades are attached to the frame and the frame is slidably received on the tie shaft of the gas turbine engine. The modular fan additionally includes an attachment member removably attaching the frame to the tie shaft of the gas turbine engine to removably install the modular fan in the gas turbine engine.
Patent CA-2949822-A1 (CA)
Inventor: BERNSTEIN IAN
IPC: G06F3/01
Filed: 2015-05-22
Abstract: A system and method to cause associated connected devices to perform gestures in response to user interactions with a connected device paired with the associated connected devices. The method includes receiving a gesture signal indicating a user interaction with a first connected device, identifying one or more connected devices associated with the first connected device, and, based on the user interaction, generating and transmitting a response signal to cause the one or more associated connected devices to perform a specified gesture signifying the user interaction with the first connected device.
Patent CA-2952961-A1 (CA)
Inventor: YARDEN YOSEF
IPC: A61P35/00
Filed: 2015-06-25
Abstract: A method of treating cancer in a subject in need thereof is provided. The method comprising administering to the subject a receptor tyrosine kinase (RTK)- specific cancer therapy and a glucocorticoid or a glucocorticoid analog, such that an efficacy window of said RTK-specific cancer therapy and an efficacy window of said glucocorticoid or glucocorticoid analog substantially overlap.
Patent CA-2953149-A1 (CA)
Inventor: WU DIANQING
IPC: C07K16/18
Filed: 2015-06-30
Abstract: The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor angiogenesis, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of DKK2 gene depleting agent, methods for providing anti-tumor immunity and anti-tumor angiogenesis in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor angiogenesis in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods.
Patent CA-2954731-A1 (CA)
Title: Composite centralizer blade
Inventor: GAO BO
IPC: E21B17/10
Filed: 2014-08-18
Abstract: In accordance with embodiments of the present disclosure, a centralizer for aligning a tubular in a wellbore includes a stepped centralizer feature. The stepped centralizer feature includes a composite material with a stepped profile. That is, the stepped centralizer feature includes a first layer of the composite material having a convex rounded side for interfacing with the tubular, and a second layer of the composite material extending from the first layer. The first layer is wider than the second layer. The stepped centralizer feature may be a centralizer blade bonded to an outer surface of the tubular, or a stop collar used to hold a centralizer spring in place on the tubular. The stepped centralizer feature helps to distribute stress through the centralizer feature so that the centralizer feature does not crack or de-bond from the tubular in low temperature, high pressure environments.
Patent CA-2955745-A1 (CA)
Inventor: SCHULTZE DENNIS
IPC: A01H5/10
Filed: 2017-01-23
Abstract: Disclosed is the seed of a novel soybean variety, designated MN11278981, a sample of which is deposited under ATCC Accession No. PTA-123685. Also disclosed are plants, or parts thereof, grown from the seed of the variety, plants having the morphological and physiological characteristics of the MN11278981 variety, and methods of using the plant or parts thereof in a soybean breeding program. The invention also relates to cells and uses of soybean variety MN11278981.
Patent CA-2956869-A1 (CA)
Inventor: GABOARDI MAURO
IPC: A61K31/683
Filed: 2015-07-29
Abstract: Sofosbuvir in crystalline Form a, process for its production and use in pharmaceutical compositions.
Patent CA-2957207-A1 (CA)
Inventor: WADA HIROSHI
IPC: A01P3/00
Filed: 2015-06-11
Abstract: La présente invention concerne : un composé représenté par la formule [1] ou un sel de celui-ci ; une composition fongicide comprenant le composé ou un sel de celui-ci ; un procédé pour éliminer les maladies des plantes transmises par des micro-organismes pathogènes des plantes, qui comprend une étape d'application de la composition fongicide ; et un procédé de production du composé.
Patent CA-2959477-A1 (CA)
Title: Multiplexed same type-antigenic peptide
Inventor: MASUDA KENICHI
IPC: C07K17/02
Filed: 2015-06-11
Abstract: The present invention provides a synthetic peptide whereby antibodies to an autoantigen can be derived, and specifically provides: a multiplex alloantigenic peptide including a dendritic core and a B-cell-recognition peptide, the multiplex alloantigenic peptide including four to eight B-cell recognition peptides of the same type bonded directly or via a spacer to a terminal end of the dendritic core, the peptides being bonded directly or via a spacer to the terminal end of the dendritic core; an antibody production inducing agent including the peptide; and a method for producing the peptide.
Patent CA-2960190-A1 (CA)
Title: Systems and methods for monitoring globally distributed remote storage devices
Inventor: PEACOCK ALEN LYNN
IPC: G06F17/30
Filed: 2015-09-02
Abstract: Methods and systems are described for remotely monitoring a plurality of distributed remote storage devices. An example computer implemented method includes locally collecting monitoring data for one of the plurality of distributed remote storage devices, and periodically sending at least one of an aggregate of the locally recorded monitoring data and a summary of the locally recorded monitoring data to a remote location. The remote location includes at least one of another one of the plurality of distributed remote storage devices, at least one central server, and a set of the plurality of distributed remote storage devices.
Patent CA-2961943-A1 (CA)
Inventor: YUE STEVEN
IPC: H02J7/00
Filed: 2017-03-23
Abstract: A power interface device includes a first connecting module, a second connecting module and a processing module. The processing module performs the following:  receiving a supply voltage through the first connecting module from a power supply device that employs a fast charging technology and that provides, based on an informing output, the supply voltage having a magnitude dependent on the informing output; generating the informing output; outputting the informing output to the power supply device through the first connecting module; and starting to output the supply voltage to the second connecting module when determining that a condition associated with the magnitude of the supply voltage is met.
Patent CA-2964058-A1 (CA)
Inventor: MOORE ROBERT ERIK
IPC: B62M9/00
Filed: 2017-04-11
Abstract: Methods and apparatus for a composite bicycle front sprocket are disclosed herein. One embodiment discloses a composite bicycle front sprocket assembly having an outer assembly of a first material. The bicycle front sprocket assembly also has a center assembly of a second material. The center assembly is disposed at least partially within the outer assembly. The center assembly is irremovably coupled with the outer assembly. The center assembly is irremovably coupled with the outer assembly without an external fastening device to irremovably couple the center assembly with the outer assembly.
Patent CA-2964247-A1 (CA)
Title: A computer-implemented method for reducing crosstalk in a computer-based audiometer
Inventor: MAJID MICHAEL
IPC: H04R3/12
Filed: 2017-04-13
Abstract: A computer-implemented method for reducing undesired crosstalk signals on an inactive channel of a device comprising the steps of: (i) determining system volume levels required to achieve a range of desired audio output attenuation levels on an active channel of the device; (ii) determining a crosstalk compensation signal comprising a signal amplitude and associated phase shift required to reduce undesired crosstalk on the inactive channel of the device for each desired audio output attention level in the range of desired audio output attenuation levels; and (iii) generating a desired audio output attenuation level on the active channel of the device by generating a signal at the determined system volume level required to achieve said desired audio output attenuation level, and generating a contemporaneous crosstalk compensation signal on the inactive channel of the device by generating a signal at the determined signal amplitude and associated phase shift required to reduce the undesired crosstalk on the inactive channel.
Patent CA-2966677-A1 (CA)
Inventor: KOBEL KARL J
IPC: B60Q3/41
Filed: 2017-05-10
Abstract: Il est décrit un affichage lumineux disposé sur la barre tactile dune porte passagère dun véhicule de transport en commun. Laffichage lumineux en question comprend un écran daffichage pouvant présenter plusieurs couleurs continuellement ou de manière intermittente à la commande dun utilisateur, un moyen de commande qui éteint lécran daffichage lorsque la porte est fermée, qui affiche une première couleur à lécran une fois lautorisation à ouvrir accordée par lopérateur, qui fait apparaître une deuxième couleur à lécran lorsque le passager demande louverture de la porte, qui fait clignoter la deuxième couleur à lécran lorsque la porte souvre, qui affiche la deuxième couleur à lécran de manière continue lorsque la porte adopte la position ouverte et qui fait clignoter une troisième couleur à lécran lorsque la porte se ferme.
Patent CA-2967778-A1 (CA)
Inventor: HANADA KENICHI
IPC: C07K16/26
Filed: 2015-11-12
Abstract: Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope ofthyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
Patent CA-2968755-A1 (CA)
Title: Air bearing for use as an adjustable contact pressure brush
Inventor: DEVITT ANDREW
IPC: H01R39/02
Filed: 2013-11-20
Abstract: A non-contact bearing has opposing surfaces (551,560) with relative motion and one surface (560) issuing higher than ambient pressure through a porous restriction, wherein the porous restriction (558) is part of a monolithic porous body, or a porous layer, attached to lands containing a labyrinth (557), the porous restriction and lands configured to not distort more than 10% of a gap (559) created from differential pressure between each side of the porous restriction.
Patent CA-2970644-A1 (CA)
Title: Sensor array packaging solution
Inventor: BISHOP JAMES E
IPC: G01D11/24
Filed: 2015-12-04
Abstract: A gigahertz sensor array packaging solution for harsh operating environments is disclosed. The sensor array packaging system includes a structural core body comprising sensor mounting features on a surface thereof and an alignment through hole extending from the surface to a backside thereof which incorporates finned features providing cooling and stiffness. The sensor array packaging system further includes one or more electro-optical components mounted to the backside of the structural core body. The sensor array packaging system further includes a wiring board comprising a plurality of sensor array elements contacting walls of the spiral ribbon configuration, each having a cable extending through the through hole to at least one of the one or more electro-optical components.
Patent CA-2971051-A1 (CA)
Title: Multicore optical fiber for multipoint distributed sensing and probing
Inventor: PARE CLAUDE
IPC: G01D5/26
Filed: 2017-02-16
Abstract: A multicore optical fiber is provided and includes a cladding and multiple cores disposed in the cladding. Each core has a light-guiding path and follows a helical trajectory about the fiber axis. The multicore fiber also includes a set of discrete lateral coupling zones, which are longitudinally distributed and azimuthally aligned with respect to the fiber axis. Each lateral coupling zone forms an optical coupling path, which enables at least one of lateral in-coupling and out-coupling of light between a corresponding one of the cores and an exterior of the multicore fiber. An optical probing system for light delivery to and/or light collection from a probed region is also provided. The optical probing system includes a multicore optical fiber to enable coupling of guided light out of the cores for delivery to the probed region and/or collection of light from the probed region for coupling into one of the cores.
Patent CA-2971362-A1 (CA)
Title: Compression molding assembly and methods for molding a thermoplastic blocker door
Inventor: GAW KEVIN O'BRIEN
IPC: B29C39/10
Filed: 2017-06-20
Abstract: A compression molding assembly for molding a honeycomb core, including a plurality of cells defined by a plurality of walls, of a blocker door is provided. The compression molding assembly includes a ram plate comprising a plurality of openings defined therethrough and a plurality of core inserts coupled to the ram plate such that the plurality of core inserts are configured to form the honeycomb core of the blocker door. Each core insert is removably coupled with a respective opening of the plurality of openings such that each core insert is configured to form a respective cell of the plurality of cells.
Patent CA-2972488-A1 (CA)
Title: Networked barcode verification system
Inventor: MARTI BENJAMIN J
IPC: G07B11/00
Filed: 2010-03-04
Abstract: A method of verifying a barcode comprises, among other steps, transmitting, at the ticket posting system, a verification request over a network to a verification system, the verification request including at least the barcode data and the seat data, the ticket posting system being a third party system to the verification system, initiating, at the verification system, a verification process in response to receiving the verification request, the verification process including determining if the barcode data corresponds to stored barcode data associated with a valid ticket, the stored barcode data being stored at a data store associated with the verification system, and determining if the seat data corresponds to stored scat data associated with the valid ticket, the stored seat data being stored at the data store associated with the verification system.
Patent CA-2973364-A1 (CA)
Inventor: BARCELOS NATHANIEL
IPC: E04H4/16
Filed: 2016-02-22
Abstract: Example embodiments of the present disclosure are directed to a robotic pool cleaner and a control system of a robotic pool cleaner having an optical sensor positioned relative to an intake pathway of the robotic cleaner to monitor a flow of material through the intake pathway. An output of an optical sensor of the robotic poo!  cleaner can be monitored by the control system of the robotic pool cleaner to determine whether a detectable level of debris is flowing through the intake pathway. The robotic pool cleaner can perform one or more operations in response to a determination that a detectable level of debris is flowing through the intake pathway based on the output of the optical sensor.