baber/WOPTO huggingface dataset:
Patent IL-115051-A0 (IL)
Title: Cell cycle regulated repressor and dna element
IPC: A61P7/02
Filed: 1995-08-23
Abstract: PCT No. PCT/EP95/03370 Sec. 371 Date Apr. 18, 1997 Sec. 102(e) Date Apr. 18, 1997 PCT Filed Aug. 25, 1995 PCT Pub. No. WO96/06940 PCT Pub. Date Mar. 7, 1996A DNA sequence for the gene therapy of tumors is described. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated, in a cell-specific manner, in proliferating endothelial cells or in cells which are adjacent to these endothelial cells. This activation is regulated by the promoter module in a cell cycle-specific manner. The active substance is an inhibitor of angiogenesis or a cytostatic or cytotoxic molecule. The DNA sequence is inserted into a viral or non-viral vector which is supplemented with a ligand which possesses affinity for the activated endothelial cell.
Patent IL-132858-A0 (IL)
Title: Computerized fluid supply systems
IPC: B67D7/34
Filed: 1999-11-10
Abstract: This invention discloses a computerized fluid supply system including a controller controlling at least supply of a fluid via a fluid fill nozzle to a tank, a fluid tank mounted identifier (164), a fluid fill nozzle mounted tank identification reader assembly, the fluid fill nozzle reader (18) being in wireless communication with the tank identifier for receiving tank identification information therefrom and with the system controller, the fluid fill nozzle mounted tank identification reader assembly including a conduit portion (16) connected in series with the nozzle (12) and electronic circuitry mounted exteriorly of the conduit portion. <IMAGE>
Patent IL-134298-A0 (IL)
Title: Hypoxia-regulating genes
IPC: C12N15/09
Filed: 1998-08-21
Abstract: According to the present invention, purified, isolated and cloned nucleic acid polynucleotide encoding hypoxia-regulating genes and the proteins thereof and antibodies directed against the proteins which have sequences as set forth in SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6 are provided. The present invention further provides transgenic animals and cell lines as well as knock-out organisms of these sequences. The present invention further provides methods of regulating angiogenesis or apoptosis or regulating response to hypoxic conditions in a patient in need of such treatment. The present invention also provides a method of diagnosing the presence of ischemia in a patient including the steps of analyzing a bodily fluid or tissue sample from the patient for the presence or gene product of at least one expressed gene (up-regulated) as set forth in the group comprising SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:5; and SEQ ID NO:6 and where ischemia is determined if the up-regulated gene or gene product is ascertained.
Patent IL-134873-A0 (IL)
Title: Method for producing triazolinthione derivatives
IPC: C07D249/12
Filed: 1998-09-25
Abstract: According to a novel process, triazolinethione derivatives of the formulain which R1 and R2 are each as defined in the description, can be prepared bya) reacting hydrazine derivatives of the formula with formaldehyde and thiocyanate of the formulain which X represents sodium, potassium or ammonium, in the presence of a diluent and if appropriate in the presence of an acid, andb) reacting the resulting triazolidinethiones of the formulaeitheralpha) with oxidizing agents, if appropriate in the presence of a catalyst and in the presence of a diluent, orbeta) with formic acid.The triazolidinethiones of the formula (IV) are novel.
Patent IL-136392-A0 (IL)
Title: Improved method for the identification and characterization of interacting molecules using automation
IPC: C12N15/09
Filed: 1998-11-27
Abstract: The present invention relates to an improved method for the identification and optionally the characterization of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention further relates to a kit useful for carrying out the method of the invention. The present invention provides for parallel, high-throughput or automated interaction screens for the reliable identification of interacting molecules.
Patent IL-139988-A0 (IL)
Title: Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
IPC: C12N1/21
Filed: 1999-06-01
Abstract: Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell surface serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1 ). Among the compositions provides are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. Several monoclonal antibodies specifically reactive with 20P1F12/TMPRSS2 are also described herein.
Patent IL-142900-A0 (IL)
Title: Compositions and methods for the prevention or treatment of cancer and bone loss associated with cancer
IPC: A61K45/00
Filed: 2000-08-18
Abstract: The present invention relates to compositions and methods for the prevention and/or treatment of bone loss associated with cancer. More particularly, the invention relates to OPG compositions and methods for the prevention and/or treatment of bone loss comprising said compositions. The invention also relates to the use of OPG compositions for the treatment of multiple myeloma.
Patent IL-147644-A0 (IL)
Title: Method for rnase-and organic solvent-free plasmid dna purification using tangential flow filtration
IPC: C12N15/10
Filed: 2000-07-21
Abstract: A process is described for purifying plasmid DNA from prokaryotic cells comprised thereof. This process comprises the steps of: (a) digesting the cells; (b) incubating the cells for about 4 to 24 hours to effect lysis and solubilization thereof, without effecting enzymatic digestion of RNA; (c) removing lysate contaminants from the cells to provide a plasmid DNA solution; (d) filtering the solution through a tangential flow filtration device to obtain a retentate containing the plasmid DNA; and (e) collecting the retentate.
Patent IL-148152-A0 (IL)
Title: Sequence-specific dna recombination in eukaryotic cells
IPC: A61P17/00
Filed: 2000-08-29
Abstract: Sequence-specific recombination (SSR) of DNA in a eukaryotic cell, comprising introducing two DNA sequences (I, II) into a cell, and using an integrase (Int) to effect SSR, is new. Independent claims are also included for the following: (1) a nucleic acid comprising a 243 base pair sequence (IIII), fully defined in the specification, or its derivatives; and (2) vector containing (III), or its derivatives, plus a therapeutic gene, or its derivatives. ACTIVITY : None given. MECHANISM OF ACTION : Gene therapy. No biological data is given.
Patent IL-153957-A0 (IL)
Title: Incremental and continuous data compression
IPC: H03M7/30
Filed: 2001-07-18
Abstract: A data compression system and method that is capable of detecting and eliminating repeated phrases of variable length within a window of virtually unlimited size.
Patent IL-154213-A0 (IL)
Title: Method of preparing a compound concentrate and processing such a concentrate
IPC: A01N25/04
Filed: 2001-07-30
Abstract: The invention relates to a method of preparing a compound for the prevention of a contamination of raw materials, products, water and/or production means, which compound comprises at least hydrogen peroxide, glycerol and glycol acid, and wherein a mixture of glycerol and glycol acid is added to the hydrogen peroxide. The glycerol and glycol acid are combine and stirred while admixing a stabilizer for peroxide mixtures to form a stable gel-like concentrate, and subsequently when required, the concentrate is added in its entirety to the hydrogen peroxide in a previously determined ratio in order to form the compound.
Patent IL-157447-A0 (IL)
Title: New medical uses of intercellular communication facilitating compounds
IPC: A61P7/00
Filed: 2002-02-22
Abstract: Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
Patent IL-164643-A0 (IL)
Title: Immunogogical methods and compositions for treatment of alzheimer's disease
IPC: C07K14/47
Filed: 2003-04-07
Abstract: The present invention relates to immunogenic compositions and peptides comprising residues 4-10 (FRHDSGY) of the amyloid peptide Abeta42. The invention further relates to antibodies that bind to the Abeta(4-10) antigenic determinant. The invention provides methods for treating Alzheimer's disease and for reducing the amyloid load in Alzheimers patients. The invention also relates to methods for designing small molecule inhibitors of amyloid deposition.
Patent IL-174809-A0 (IL)
Title: Inhaler
IPC: A61M15/00
Filed: 2006-04-05
Abstract: An inhaler (1) comprising a housing (2) to receive a blister (6a) having a puncturable lid (6c) and containing a dose of medicament for inhalation by a user is disclosed. It comprises a mouthpiece (5) through which a dose of medicament is inhaled by a user, a blister piercing member (7) comprising at least two discrete piercing heads (9) operable to pierce a corresponding number of holes in said blister, an actuator (3) comprising an arm pivotally mounted to the housing at one end, and an opening formed in the vicinity of each piercing head. At least one of said openings forms an airflow inlet into said blister and, at least one other of the openings forming an airflow outlet from said blister. The mouthpiece includes a primary chamber (31) having an outside air inlet (34) in communication, via the primary chamber, with the or each airflow inlet opening and, a secondary chamber (32) in communication with the or each airflow outlet opening. When a user inhales through the mouthpiece, air is drawn through the or each airflow inlet opening into the blister via the outside air inlet and the primary chamber to entrain the dose in the airflow, said entrained dose passing through the or each airflow outlet opening into the secondary chamber of the mouthpiece from where it is carried into the user's airway.
Patent IL-181621-A0 (IL)
Title: Piperidine derivative or pharmaceutically acceptable salt thereof
Filed: 2007-02-28
Abstract: The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (-R 1 ) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [-C(=O)-R 4 ], or a pharmaceutically acceptable salt thereof has an excellent sodium channel inhibition action and an excellent analgesic action and shows a high analgesic effect particularly to neurogenic pain. The present compound is useful as a sodium channel inhibitor of low side effect
Patent IL-188860-A0 (IL)
Title: Biodegradable heterophase polymeric compositions comprising a thermoplastic starch, a thermoplastic polymer incompatible with starch and an interfacial agent, process for their preparation and their use in organic and inorganic products
IPC: C08G18/42
Filed: 2008-01-17
Abstract: Polymeric compositions comprising thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected:A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophillic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them,B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio R between the average viscometric molecular weight and the melt index is greater than 25,000 andC) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyester-amides, polyester-ethers, polyester-ether-amides, polyester-urethanes and polyester-ureas and wherein the compositions are obtained by extrusion of the component maintaining a water content during the mixing stage from 1 to 5% by weight.
Patent IL-190971-A0 (IL)
Title: Method and compounds for preparing cc-1065 analogs
Filed: 2008-04-17
Abstract: A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
Patent IL-195016-A0 (IL)
Title: 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
Filed: 2008-10-30
Abstract: The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is: wherein R<SUP>1 </SUP>to R<SUP>4 </SUP>are as defined in the description and claims. The compounds of the present invention are useful for the treatment and/or prevention of diseases which are associated with the modulation of histamine 3 (H3) receptors.
Patent IL-195131-A0 (IL)
Title: Preamble structure and acquisition for a wireless communication system
IPC: H04W36/30
Filed: 2008-11-05
Abstract: Techniques for sending sector/system information in TDM pilots using a hierarchical pilot structure are described. A base station sends multiple sets of bits for the sector/system information in multiple TDM pilots. The set of bits sent in a given TDM pilot may include bits sent in earlier TDM pilots. In one design, the base station generates a first TDM pilot based on a first set of bits, generates a second TDM pilot based on a second set of bits that includes the first set, generates a third TDM pilot based on all bits for the information, and sends the TDM pilots. A terminal performs detection to obtain a first detected value for the first TDM pilot, performs detection based on the first detected value to obtain a second detected value for the second TDM pilot, and performs detection based on the first and second detected values to obtain a third detected value for the third TDM pilot.
Patent IL-210480-A0 (IL)
Title: Use of steroidal c-17 benzimidazole c-17 in the manufacture of medicaments for treating cancer
Filed: 2011-01-06
Abstract: Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic "addition-elimination" substitution reaction of 3²-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3²-ol or analogs thereof with tributylstannyl diazines. The compounds are potent inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds are useful for the treatment of human prostate cancer.
Patent IL-215112-A0 (IL)
Title: Fusion polypeptide and pharmaceutical composition comprising such
Filed: 2011-09-13
Abstract: The present invention is directed to methods of preventing reactivation of active and latent  M. tuberculosis  infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a  M. tuberculosis  infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a  M. tuberculosis  infection.
Patent RO-125193-A0 (RO)
Title: Piezoelectric micromotor
Inventor: CERNOMAZU DOREL
IPC: H02N2/00
Filed: 2008-12-23
Abstract: The invention relates to a piezoelectric micromotor that can be used to drive independent mechanisms with simultaneously adjustable speeds. According to the invention, the piezoelectric micromotor comprises a stator consisting of a circular elastic membrane (1) made of brass, whereto a piezoelectric disc (2) is attached, said disc (2) being fixed to a support (3) by means of a clamping part, the resulting assembly driving some rotors (7 and 7') located on some horizontal shafts (8 and 8') and pretensioned by some springs (9 and 9'), the assembly being radially movable due to a guiding system consisting of a support piece (5) sliding along a guiding rod (4), the stator being supplied from a signal generator (11).
Patent RO-129712-A0 (RO)
Title: Composite material based on coremat usable in the construction of underground shelters and motor vehicle components and process for manufacturing the said material
Inventor: PURCĂREA RAMONA
IPC: B32B7/02
Filed: 2013-05-24
Abstract: The invention relates to a composite material used in the motor vehicle components industry and to a process for obtaining the same. According to the invention, the composite material consists of a plurality of layers, as follows: a glass fiber layer () with the specific mass of 1x450 g/m, a core () having a size of 4 mm made of Coremat composite, a glass fiber layer () with a specific mass of 1x450 g/m, some layers () made of glass fiber fabric with a specific mass of 1x845 g/mand a layer () made of glass fiber fabric with the specific mass of 1x485 g/m. As claimed by the invention, the process consists in positioning and impregnating, each respective layer, afterwards there follows the structure polymerization, to result in a composite with a rigidity to bending of 62352 N/m, a breaking tension of 114.97 MPa, a traction rigidity of 15448000 N/m and a breaking tension of 15.754 MPa.
Patent RO-131643-A0 (RO)
Title: Hole boring auger with inner mechanism
Inventor: TUDOSIU CĂTĂLIN
IPC: E02F5/20
Filed: 2016-09-02
Abstract: The invention relates to an auger with inner mechanism meant to be used as an active working member for hole drilling machines and borers, driven by an independent power source, such as tyred or crawled tractor, which can perform the hole drilling stage and also placing a working load at the lower limit of the hole. The auger, as claimed by the invention, consists of two cylindrical bodies (1 and 2), one body (2) being placed concentrically inside the first body, by means of two cylindrical guides (3) distributed allover the length Iof the auger, where the cylindrical body (1) is built of a pipe section with an outer diameter (D) on which the boring auger-type helical screw (16) with the outer diameter Dand the undeveloped length I, placed on the generatrix thereof is located, having at the lower part a stopping guide (10) of bush-type, provided with a thread, and the inner cylindrical body (2) is made of a pipe segment with an inner diameter Dassembled with some elastic pincers (9) having at the upper part a slideway (5) for driving in the vertical plane, provided with the articulation (6) placed on the inner body (2) and the bolt-type articulation (7) placed in a recess, which, when actuating the lever (8), allows the inner body (2) to be moved vertically, having at the lower part a spiral spring (11), the travel (h) of which is limited at the upper part by a stopper (12) made integral with the body (2) and at the lower part by the collar of the stopping guide (10), which, by the compression made by lever (8) cancels the compression of the elements of the elastic pincers (9), it has a flange (15) made integral to the diameter-reducing piece (14) which is provided with a recess of a charging hole-type, whose end is represented by the flange (13) mounted at the reduction gear box (4) of the hole drilling machine, provided with a direction reverser device.
Patent RO-132393-A0 (RO)
Title: Magnetic nanofluid sealing systems for high peripheral speeds
Inventor: BORBATH ISTVAN
IPC: F16J15/43
Filed: 2017-09-27
Abstract: The invention relates to a rotary sealing system with magnetic nanofluid meant to be used in equipments operating at high peripheral speeds. According to the invention, the sealing system comprises a permanent magnet (1), polar pieces (2) with conjugated toothing, formed of grooves and teeth, a magnetic nanofluid (3) retained in an annular shape in the gap area between the polar pieces (2) and a toothed magnetic shaft (4) with grooves and teeth, a housing (5) and some bearings (6), where the polar pieces (2) are made of two half-rings, so as to form, when mounted on the shaft (4), two sealing zones, one formed by the grooves of the polar pieces (2) and the teeth of shaft (4) and the other formed by the grooves of the shaft (4) and the teeth of the polar pieces (2).
Patent RO-132472-A0 (RO)
Title: Food supplement for reducing gastroesophageal reflux
Inventor: MATRAN IRINA MIHAELA
IPC: A61P1/04
Filed: 2017-10-02
Abstract: The invention relates to a food supplement for reducing gastroesophageal reflux. According to the invention, the supplement consists of 10...16.5% mixture of medicinal plants selected from Achillea millefolium, Calendula officinalis, Matricaria recutita, Plantago lanceolata and Robinia pseudoacacia, 60...72% ecological cocoa butter, 0.5...2% Hippophae rhamnoides oil, 0.5...2% propolis tincture, 0.4...4% bees wax and 0.5...4% baking soda, the percentage being expressed by mass.
Patent MA-23862-A1 (MA)
Inventor: JOEL BOUIMMIS
IPC: F17C13/06
Filed: 1996-05-08
Abstract: The tank comprises: (i) a metal shell (1) with an outer polyester or epoxy coating; and (ii) an access well (3) for fittings (2) made from plastic and connected to the outer surface of the tank by a saddle (4) on lower end.
Patent MA-20150257-A1 (MA)
Inventor: FADIL TARIK
IPC: G06F12/00
Filed: 2013-12-09
Abstract: يقدم هذا الإختراع حلا معلوماتيا ( أجهزة - برمجيات) لإيداع الملفات أو تقديم طلبات معالجة الوثائق و ذلك بالإعتماد على قارئ آلي  للمعلومات البيومترية للبطاقة التعريف الوطنية الإلكترونية من أجل تصديق مشخص للمواطنين ، و يطبق هذا النظام  تصديق متعدد العوامل من خلال قراءة بصمات الأصابع والتعرف على وجه المستعمل- المواطن. أثناء عملية القراءة،يقوم النظام بحفظ  توقيع و صورة المواطن و يستعمل تقنية ocr لتحليل المحتوى و رقمنة الوثيقة التي ستتم معالجتها من طرف الجهة المستقبلة حيث أصبح بإمكان المواطن أو المستعمل الإمضاء الالكتروني على الوثيقة كما يمكن  هذا النظام من تسهيل عملية إيداع الوثائق و يتألف الملف الإلكتروني من النظام المعلوماتي و الجهة المستقبلة، النظام متوفر في نسختين : نسخة محطة (كشك) أو  نسخة آلية sdl agent يتم تشغيلها من طرف موظفي الجهة المستقبلة، و يتكون هذا الحل المعلاماتي من : 1. بوابة على شبكة الانترنت و تطبيق معلوماتي و نظام إدارة
Patent MA-37209-A1 (MA)
Title: Superstrat méta-matériaux multi-bandes et isotrope pour l'absorption des ondes électromagnétique et la transformation énergétique à haute efficacité
Inventor: LALJ HICHAM
IPC: H01Q15/00
Filed: 2014-07-14
Abstract: La présente invention concerne un système d’amplification multi bandes des ondes électromagnétiques par le biais d’un superstrat méta-matériaux ayant simultanément ou/et séparément au moins un double fonctionnement. Le premier fonctionnement consiste à une absorption avec aiguillage des ondes électromagnétiques dans une direction de propagation particulière. Le deuxième fonctionnement consiste à amplifier les ondes électromagnétiques rayonnées d'une manière bidirectionnelle depuis ou vers une ou plusieurs sources électromagnétiques multi bandes. L’invention consiste en un superstrat 1d, 2d ou 3d contenant un arrangement de cellules méta-matériaux unitaires ayant la particularité d'une résonance multi-bande et isotrope.