Patent GB-1397623-A (GB)
Title: Composition for topical application for counteracting the greasy  appearance of the head of hair and/or the skin
IPC: C07D307/38
Filed: 1972-04-21
Abstract: 1397623 Pharmaceutical compositions L'OREAL 21 April 1972 [23 April 1971] 34610/74 Divided out of 1397621 Heading A5B A composition suitable for topical application comprises a suitable vehicle, a perfume, and, as active ingredient, at least one compound of the formula: in which: 1) n is 0 or 1 such that: if n=0: R 1  and R 2  each independently represents a hydrogen atom, or a methyl radical and if n=1: R 1  and R 2  each represent a hydrogen atom. 2) R 3  is chosen from: either under definition (a) in which R 3  represents -OH or an alkoxy radical with 1 to 5 carbon atoms, or under definition (b) in which R 3  represents a radical of the formula II: in which y' and y" each independently represents an alkyl radical with 1 to 3 carbon atoms or, together with the nitrogen atom to which they are attached, form a morpholino, piperidino, pyrrolidino or N'-methyl-piperazino radical; a radical of the formula: -OCH 2 -CHOH-CH 3 , a glucosamino group, a -NH-NH 2  radical, a -NHOH radical or a radical of the formula: wherein y"' represents a hydrogen atom or an alkyl radical with 1 to 3 carbon atoms. 3) A is chosen from either under definition (a) in which: A represents a hydrogen atom, a nicotinoyl radical, a benzoyl radical, a radical of the formula -COR 4  or -SO 2 R 4  in which R 4  represents: an alkyl radical with 1 to 6 carbon atoms, or a radical of the formula: in which R 5  represents a hydrogen atom, a methyl radical, an alkoxy radical with 1 to 4 carbon atoms or an acetamido radical, or under definition (b) in which A represents a -CONH 2  radical, a glutamyl group, an isonicotinoyl group, a picolinoyl group, a -COR 6  radical wherein R 6  represents: a hydrogen atom, an alkyl radical with 7 to 18 carbon atoms, an alkenyl radical with 2 to 18 carbon atoms, a -CH 2 Cl radical, a -CF 3  radical, a radical of the formula: a radical of the formula: or its N-oxide derivative; a radical of the formula: a radical of the formula: a -CH 2 -CH 2 -COOH radical; a radical of the formula VII wherein R 7  represents an alkyl radical with 2 to 4 carbon atoms or a halogen atom, a radical of the formula: in which R 8  represents an alkyl radical with 1 to 4 carbon atoms, an alkoxy radical with 1 to 4 carbon atoms, a halogen atom or an acetamido radical, or a radical of the formula SO 2 R 9  in which R 9  represents either a radical of the formula VII in which R 7  is as defined above, or a radical of the formula: C 6 H 5 - CO-CH 2 - 4) t is 1 or 2 such that: if t=1 R is chosen from either under definition (a) in which R represents: -C(C 6 H 5 ) 3 , -CH (C 6 H 5 ) 2 , C 6 H 5 -CH 2 - or -(CH 2 ) 8 COR 10  in which s is from 1 to 4 and R 10  represents either OH or an alkoxy radical with 1 to 5 carbon atoms; or under definition (b) in which R represents a linear or branched alkyl radical with 1 to 18 carbon atoms, an alkenyl radical with 3 to 18 carbon atoms, an alkyl radical with 2 to 4 carbon atoms substituted by 1 or 2 hydroxyl radicals, a prop-2-ynyl radical, a radical of the formula: in which n, A and R 3  are as defined above, a radical of the formula: -CH 2 -(CH 2 ) n -CH 2 -NHA in which n and A are as defined above, a radical of the formula: a radical of the formula: in which m is 1 or 2, R"' represents an alkyl radical with 1 to 4 carbon atoms and B represents a divalent radical a radical of the formula -(CH 2 ) p -R 11  in which p is 0, 1 or 2 such that if p=0, R 11  represents either a 1-naphthyl or a 2-naphthyl radical; if p=1, R 11  represents a 1-naphthyl or 2-naphthyl radical a 2-thienyl radical, a 2- tetrahydrofuryl radical, a 2-furyl radical or a 2-pyridyl-N-oxide radical; if p=2, R 11  represents a 2-pyridyl-N-oxide radical; and, in addition, if p=0, 1 or 2, R 11  represents a 2- pyridyl radical or a 2-pyridyl radical substituted by a nitro radical or an alkyl radical with 1 to 4 carbon atoms; a radical of the formula: in which q is 1, 2 or 3 and R 12  represents a halogen atom, a hydrogen atom if x is other than 1, an alkoxy radical with I to 5 carbon atoms or a branched or linear alkyl radical with 1 to 4 carbon atoms; such that, in addition, if q is 1, R 12  represents an alkylsulphonyl radical, an alkylthio radical, an alkylsulphinyl radical or a dialkylamino radical, the alkyl group having 1 to 5 carbon atoms, or an amino radical, a phenoxy radical, a cyclohexyl radical, an acetamido radical, a methylenedioxy radical, a nitro radical, a phenyl radical or a trifluoromethyl radical, with x representing 0, 1 or 2, a 1, 2-dichloro-vinyl radical, a -CONH 2  radical, a -C(CH 3 ) 3  radical, a -CH(C 6 H 4 -p-OCH 3 ) 2  radical, a -C(CH 3 ) 2  (C 6 H 4 -p-OCH 3 ) radical or a radical of the formula (CH 2 ) z COR 13  in which z represents 1-5 and R 13  represents a radical of the formula II wherein y' and y" are as defined above, a radical of the formula -O-CH 2 - CHOH-CH 3 , a glucosamino radical, a -NH -NH 2  radical, a -NHOH radical, a -NH 2  radical, a -N-(CH 2 CH 2 OH) 2  radical or a radical of the formula: wherein y' and y" are as defined above, if t=2, R represents an alkylene radical with 2 to 4 carbon atoms or an alkylene radical substituted by 1 or 2 OH radicals, or a butenylene radical or a radical of the formula: with the proviso that if t= 1 , n=0 and R 1 = R 2 =H, at least one of the radicals A, R and R 3  is defined under a definition (b).