baber/WOPTO huggingface dataset:
Patent DO-P2006000004-A (DO)
Title: Compuestos de quinolina heteroaromaticos.
Inventor: HUMPHREY JOHN MICHAEL
Filed: 2000-05-17
Abstract: La invención se refiere a compuestos heteroaromáticos que sirven como inhibidoes de fosfodiesterasa (PDE) eficaces. En particular, la invención se refiere a dicho compuestos que son inhibidores selectivos de PDE10. La invención también se refiere a intermedios para la preparación de dichos compuestos; a compociciones farmacéuticas que comprenden dichos compuestos; y al uso de dichos compuestos en un procedimiento para tratar cierto trastornos del sistema nervioso central (SNC) u otros trastornos.
Patent DO-P2017000244-A (DO)
Title: Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap)
Inventor: JOHAN OLOF BRODDEFALK
IPC: C07D498/04
Filed: 2017-10-20
Abstract: La presente solicitud se refiere a compuestos de fórmula (I) a su utilidad para tratar y/o prevenir afecciones clínicas incluyendo enfermedades cardiovasculares (ECV), a métodos para su uso terapéutico, a composiciones farmacéuticas que los contienen y a procesos para preparar dichos compuestos.
Patent DO-P2018000059-A (DO)
Title: Composiciones de insulina de rápida acción
Inventor: MICHAEL PATRICK AKERS
IPC: A61K47/12
Filed: 2018-02-23
Abstract: La presente invención se refiere a una composición farmacéutica de insulina humana o análogo de insulina que incluye citrato, treprostinilo y agentes estabilizantes, que tiene acción farmacocinética y farmacodinámica más rápida que las formulaciones comerciales de productos análogos de insulina existentes y que es estable para uso comercial.
Patent EC-SP10010303-A (EC)
Title: (dihidro)pirrolo[2,1-a]isoquinolinas
Inventor: TIMMERS CORNELIS MARIUS
IPC: A61K31/551
Filed: 2010-06-23
Abstract: La invención se refiere a derivados de 5,6-dihidropirrolo[2,1-a]isoquinolina y pirrolo[2,1-a]isoquinolina de acuerdo con la Fórmula general I o una sal farmacéuticamente aceptable de los mismos. Los compuestos pueden usarse para el tratamiento de la infertilidad.
Patent EC-SP10010497-A (EC)
Title: Inhibidores de desacetilasas b a base de hidroxamato
Inventor: LIU GANG
IPC: A61K31/4025
Filed: 2010-09-24
Abstract: Las enseñanzas de la presente invención se refieren a los compuestos de la Fórmula I; y sales, hidratos, ésteres, y profármacos farmacéuticamente aceptables de los mismos, en donde R1, R2, R3, Y, Z, y son tal como se define en la presente invención. Las enseñanzas de la presente invención también proporcionan métodos para preparar los compuestos de la Fórmula I y métodos para utilizar compuestos de la Fórmula I para el tratamiento, inhibición, o prevención de condiciones o trastornos patológicos transmitidos en su totalidad o en parte por desacetilasas.
Patent GB-189701057-A (GB)
Title: Improved Cardboard Box and its Manufacture.
Inventor: TEMLER JOSEF
Filed: 1897-01-14
Granted: 1897-02-20
Abstract: 1057. Temler, J. Jan. 14. Cardboard boxes.-The body a is attached to the bottom c by means of a metallic grooved strip b. The body is formed with a bead a<1>, Fig. 3, to receive the strip, the bead being conveniently formed by creasing or grooving and then cutting as at a<1>, Fig. 4. The strip is first attached to the body and then, when the latter is formed by securing the edges together, the bottom is sprung into place.
Patent GB-189708051-A (GB)
Title: Improved Means for Closing Bottles, Flasks, Cans, and the like.
Inventor: MEWBURN JOHN CLAYTON
Filed: 1897-03-29
Granted: 1897-05-01
Abstract: 8051. Mewburn, J. C., [Lingner & Kraft]. March 29. Stoppers.-Relates to means for closing bottles, flasks, cans, &c. The cover A which closes the neck of the vessel, is formed with an eccentric aperture a, and is fitted with a revoluble cap B having a similar eccentric aperture c. A closing- piece d, which turns with the cap B but is not connected to it, is adapted to close the aperture a when the cap is in the position shown. By rotating the cap, the aperture a is uncovered, and the aperture c is brought to coincide with it, to permit the contents to be poured out. The crown of the closing-piece d may project through an aperture b in the cap B, as shown in Fig. 4, or a pin fixed to the cap may engage in a recess in the crown of the closing-piece, as shown in Fig. 5, or a spring may be interposed between the cap and closing-piece, &c. The aperture a may be formed in the centre of the cover A, the closing-piece being carried by a plate pivoted eccentrically to the cover.
Patent GB-189709060-A (GB)
Title: Improvements in Buttons, Knobs, and Appliances for fixing the same.
Inventor: RYDILL GEORGE
Filed: 1897-04-09
Granted: 1898-04-02
Abstract: 9060. Rydill, G. April 9. Knobs. - A knob A, connected to a flange D by a tubular stem B, is threaded to receive a screw E and washer F, by which the knob is secured on a drawer or other article. The stem B may be formed on the head A and provided with a lining-tube C, which is flanged to enter a recess in the head A, and is turned out to secure the flange. Or part of the stem B may be formed on the flange D, or the stem may be a short tube placed on the lining tube between the head and flange, or it may be an enlarged part of this tube, dispensing with a separate liner. The edges of the clamping-parts D, F may be provided with bent teeth d or otherwise roughened. The knobs may be made of any suitable materials, such as small pieces of ivory or metal, and may be covered with ornamental metal or fabric or otherwise ornamented.
Patent GB-189718867-A (GB)
Title: Machine for Separating Bodies of the same kind according to their size.
Inventor: CASTENHOLZ ALFONS
Filed: 1897-08-14
Granted: 1898-06-04
Abstract: 18,867. Castenholz, A Aug. 14. Separating or sorting machines.-Relates to machines for gauging and separating bodies as to two dimensions, for use, for example, in separating conical bullets of standard size from imperfect ones. The articles are fed down inclined channels D<1>, D<2> and fall into slots in a plate A carried by the shaft B. As each slot passes away from the receiving- point, the pin I leaves the stop H<1> and the article is gripped between the spring- controlled check F and the adjustable fixed check E. The article is now carried clear of the supporting- table K, and is free to fall into the hopper 0 as soon as the check F is pressed back so as to release it. This is effected by the passage of the pin I past three stops, similar to H<1>, but placed at graduated radial distances, so that if the article is too short it will be released at the first one, if of normal length at the second, and if too long at the third. On falling into the hopper 0 it is stopped between the fixed check P and another check Q. This latter check is tilted aside, more or less, by the contact of the screw S with the surfaces T, the articles being again divided into three classes according to their thickness. The result is that all the normal articles are discharged at a particular opening y, being received in a box placed beneath it, while the defective ones are discharged at four distinct openings y as too short, too long, too thin, and too thick respectively.
Patent GB-189720141-A (GB)
Title: An Improved Noiseless-Door-Buffer.
Inventor: BEYER EMIL OSKAR
Filed: 1897-09-01
Granted: 1897-10-02
Abstract: 20,141. Beyer, E. O. Sept. 1. D o o r checks.-A lever B is pivoted on a plate C just above the door, and carries a spring stop A. The door is fitted with rising hinges, which communicate motion to the rod S in the direction of the arrow w h e n the door is opened. A slot s allows the door to be slightly opened before the lever is depressed behind it. A lever h is pivoted on the back of the lever B, one arm h<1> resting on an inclined sector g, and the other being connected to the stoppin t. On opening the door sufficiently, the arm h' leaves the sector, allowing the stop-pin to spring outwards. When the door closes, the arm h<1> engages the square end of the sector and prevents the lever B from being raised until the door has struck the spring stop, lifting the arm h<1>, and allowing the lever B to be raised from the path of the door by a coiled spring k to the original position shown, and thus effecting a quiet closing of the door.
Patent GB-189722234-A (GB)
Title: Improvements in Means or Apparatus for Advertising.
Inventor: NASH HERBERT
Filed: 1897-09-28
Granted: 1898-07-30
Abstract: 22,234. Nash, H. Sept. 28. Advertising.-Compartments a<2> in the lower part of a frame a are covered in front with transparent advertisements which are illuminated by electric or gas lamps f which are lighted intermittently. At the top are compartments a, a<1x>, of which the latter may be covered with fixed advertisements like the compartments a<2>, and the former are fitted with advertising frames mounted on wheels which are rotated intermittently. In connection with the upper compartments is a screen which is moved aside at intervals to represent the lamps as being gradually illuminated. The intermittent movements, the movement of the screen, and the switching on of the lamps, are produced by an endless band carrying a cam to operate a clutch, and suitable switch contacts.
Patent GB-189722307-A (GB)
Title: New or Improved Apparatus for the Playing of Table Games.
Inventor: ANDERSON DOUGLAS
Filed: 1897-09-29
Granted: 1898-09-10
Abstract: 22,307. Anderson, D. Sept. 29. Games played with projectors &c.-A spring projector is employed called a 'robinet.' This may consist of a handle, and a piece of bent sheet steel or wire C attached thereto. Balls, marbles, or discs are propelled by holding the handle with one hand drawing back the blade by the other hand applied to the end B, and then releasing it so that the part C strikes the ball &c. This projector may be used in playing a table game in imitation of croquet, the small hoops being each mounted on the ridge at the centre of a doubly-inclined plane, formed by bending a piece of tin. The projector may also be used with a truncated pyramid or cone, at the top of which is a space or a hole enclosed by wire embrasures. A smaller cone having a central hole may be mounted on this cone, so as to reduce the size of the hole. Balls or discs are propelled by the spring, so as to run up the sides of the cone &c. into the hole or enclosed space.
Patent GB-189724603-A (GB)
Title: Improvements in Apparatus for Supplying Fluids at Predetermined Times and for Predetermined Periods to Vats or Receptacles for Chemical Processes or for Analogous Purposes.
Inventor: PRENTICE HERBERT NAPIER
Filed: 1897-10-23
Granted: 1898-10-08
Abstract: 24,603. Prentice, H. N. Oct. 23. Gases and liquids, distributing.-Relates to apparatus for supplying gases and liquids at predetermined times, and for predetermined periods, to vats or receptacles, for chemical or for analogous purposes. The gas or liquid is supplied by an electrically -c o n t r o l l e d valve A. One circuit from the battery passes to swinging levers b<1>, b<2>, b<3>, b<4>, contacts c<1>, c<2>, c<3>, c<4>, the thin wire core e<1> of a double-wound magnet D, and wire d' back to the battery. The contact is made by projections a<1>, a<2>, a<3>, a<4> on a wheel or drum B, rotated once an hour by the timekeeper B<1>. There are three contacts a', two a<2>, and one a<3> for each hour, while with a<4> there is only one contact every two hours. When the contact is made, the magnet D is energized, the armature D<1> attracted, and contact is made at e. The battery current now passes by the wire d' to the armature D', contact e, coil e<2>, swinging magnet E, and back to the battery. The magnet E is then attracted, and its long arm E', pivoted at e<4>, raised so as to lift the plunger F of a dash-pot F<1>. This dash-pot arrangement is set so as to fall at any required rate, whereby the time for which the fluid shall pass is regulated. An arm D<2> projects from the armature D<1>, and the end of the arm E' as it rises strikes against it, breaking the contact at e, and making it at e<6>. The battery current then flows through the coils of a relay G, the armature G' of which is attracted to make contact at the carbons G<2>. One of the latter is connected by a wire g to any one of the four bars (each corresponding to one of the projections a', a<2>, a<3>, a<4>, that is, to a different period for which the apparatus is timed) of a plug board H, each bar having a number of plug holes corresponding to the number of the vessels into which the gas or liquid is to be distributed. When the plug h is inserted in one of the holes of the plug board, a circuit is completed from the battery C, relay G, carbons G<2>, plug board H, solenoid coil of the valve A, and back to the battery C, whereby the valve rod is lifted and gas or liquid allowed to flow. The circuit through the dash-pot being broken, the plunger will descend, more or less slowly, and, when at its lowest point, the arm E<1> strikes the armature D' and breaks the contact at e<6>, whereby the relay is no longer excited, the connection between the carbons G<2> is broken, and the circuit through the solenoid of the valve A destroyed. The valve then falls by gravity to cut off the outlet of gas or liquid.
Patent GB-189726633-A (GB)
Title: Improvement in or connected with Incandescent Gas Burners wherein Fragile Mantles are used.
Inventor: CHALMERS GEORGE WHITWELL
Filed: 1897-11-15
Granted: 1897-12-18
Abstract: 26,633. Chalmers, G. W. Nov. 15. Incandescent gas lamps. - The transmission of shocks and vibrations t o the fragile mantle is prevented by the interposition of a spiral spring B or its equivalent and a weighty inert mass C between the base A and the crown of the Bunsen burner. When a pilot jet is used, the lower part of the pilot supply pipe opens beneath, but is not in contact with, a bell on the upper part of the said supply pipe.
Patent GB-189728625-A (GB)
Title: Improvements in Channelling Machines.
Inventor: CUTLAN FREDERICK
Filed: 1897-12-04
Granted: 1898-12-03
Abstract: 28,625. Cutlan, F. Dec. 4. Cutting-machines for leather.-Relates to machines for chancelling and splitting leather, especially applicable to boot soles. The frame A has pivoted to it by trunrions B' an inner frame B in which the driving-spindle C is mounted. The machine shown is actuated by hand, but it may be driven by a treadle or by power. The work is supported on a rotating table L adjusted in height by a screw, as shown, or by a cam or other means. The work, fed by a serrated wheel K, is held flat on a table by a spring K<1>, Figs. 2 and 3, and is guided by a fence P. One knife H is carried by a bracket G, and the other H<1> is secured in the frame B by a wedge I and screw P. To adjust the distance of the knife H from the edge of the work a cam D is used, operated by a treadle and spring, while the height of the knives above the table is determined by a cam F acting on a pin E<3> projecting from a rod E hinged to the frame B. The cam is rotated by hand, and operates against a spring.
Patent GB-189808340-A (GB)
Title: Improvements in or connected with Flushing Cisterns.
Inventor: RHODES THOMAS GARFORTH
Filed: 1898-04-07
Granted: 1899-02-11
Abstract: 8340. Rhodes, T. G., and Gaunt, R. April 7. Water-waste preventers, siphon-discharge. To lessen noise, the piston for starting the siphon is fitted with a rubber stud to strike up against the ends of the starting-c y 1 i n d e r. The bell-crank starting-lever is pivoted in lugs J on a bracket K screwed on the top of the flushing-cistern to the sides N.
Patent GB-189808367-A (GB)
Title: Improvements in Vehicles fitted with Acetylene Installations.
Inventor: TEICHMANN PAUL
Filed: 1898-04-07
Granted: 1898-05-20
Abstract: 8367. Teichmann, P. April 7. Vehicles with acetylene installations.-The Figure shows a vehicle having compartments a, b, c, and d for the gas holder, generator, calcium carbide, and tools respectively. The pipes for conducting the gas are arranged on the roof.
Patent GB-189813793-A (GB)
Title: Improvements in Electric Generators.
Inventor: EDWARDS EDMUND
Filed: 1898-06-21
Granted: 1898-08-13
Abstract: 13,793. Edwards, E., [Emanuel, P. A.]. June 21. Hydro-electric machines.-Electricity is generated by passing a fluid, which may be either steam, partially-condensed steam, or hot or cold water, through a metallic tube or system of tubes coiled in the form of involute or evolute spirals, and allowing this fluid to escape into a funnel-shaped receiver ; the electricity so generated is caused to induce a secondary current in helices of a conductor surrounding the generating - coils and receiver. Fig. 2 shows a section through the upper half of the generator. Steam or water from a boiler enters an expansion chamber N, whence it passes through coiled pipes G enclosed in magnetic casings E on which are wound wire helices F. The partially-condensed steam escapes into expanding-chambers C, and the vesicles of water fall into funnel-shaped receivers K, also surrounded by wire helices F<1>. All these parts are enclosed in an insulating-body with suitable casings mounted on trunnions P<1>.
Patent GB-189816400-A (GB)
Title: Improvements in Apparatus for Removing Ashes and the like from the Stoke-holds of Ships.
Inventor: HALLETT JOSEPH
Filed: 1898-07-27
Granted: 1899-08-26
Abstract: 16,400. Hallett, J. July 27. Ships' ashes, discharging. -Fig. 2 shows, partly in section, a device for raising the ashes and discharging them overboard. 3 is a pipe leading from the stokehold over or through the side of the ship, and 5 is a receptacle which is hinged at 1 so that it can be turned into the position shown in dotted lines, to be filled, by means of the rack-and-pinion gear shown. When full, the receptacle is turned back into line with the pipe, into which the ashes are raised by the movable bottom 12 actuated by the plunger of a steam, hydraulic, or other cylinder 15. The receptacle is then again moved aside, the plate 7 retaining the ashes in the pipe. This apparatus may be modified as regards details, and may be provided with locking-devices to prevent the plunger from being actuated when the receptacle is not in a suitable postion and vice versÔ. Fig. 14 shows another form of apparatus, in which the ashes fall from the hopper 44 in front of a reciprocating plunger 42 which forces them into the pipe 3a.
Patent GB-189819568-A (GB)
Title: Improvements in or connected with Parquetry Blocks and Strips for use in Parquetry Floors of all kinds.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1898-09-14
Granted: 1899-07-15
Abstract: 19,568. Thompson, W. P., [Isler, G.]. Sept. 14. Flooring-blocks.-Plates or strips b of cork or peat are fixed to the backs of parquetry blocks a to deaden sound, absorb moisture, and prevent the accumulation of infectious matter. The strips extend to the edges of the blocks, and meet when the blocks are laid.
Patent GB-189821517-A (GB)
Title: Improved Apparatus for Transporting Ships' Boats across the Deck.
Inventor: KLENCKE JOHANN HEINRICH
Filed: 1898-10-13
Granted: 1898-12-10
Abstract: 21,517. Klencke, J. H. Oct. 13. Boat raising, lowering, and supporting gear.- Relates to means for conveying ships' boats across the deck so that they can be lowered from either side. A pair of beams or skids F have running on them carriages H provided with hoisting-gear. As shown in Fig. 1, the boat B' is raised to the position B<2>, run across to B<3>, lowered and transferred to the davits, and then swung out into the position B<4>, ready for lowering. When there are obstructions between which the boats have to pass, the tackles are secured to rails G, Fig. 4, at the bow and stern of the boat, so that it can be passed between the obstructions in the manner shown in Fig. 3.
Patent GB-189825966-A (GB)
Title: Improvements in the Manufacture of Indigo.
Inventor: JOHNSON JAMES YATE
Filed: 1898-12-08
Granted: 1899-10-14
Abstract: 25,966. Johnson, J. Y., [Badische Anilin & Soda Fabrik]. Dec. 8. Dyes, artificial.-Indigo leuco compounds are produced from anthranilic acid, or its salts or ethers, by heating these compounds with a polyhydric alcohol, or a derivative thereof, such as glycerine, alpha-chlorhydrin, epichlorhydrin, acetin, ethyleneglycol, mannite, starch, or cellulose in the form of cotton wool or the finest dried sawdust, in presence of a caustic alkali, with or without the addition of an alkaline earth. If an alkali compound such as sodium, potassium, or calcium glycerate, is used, a free alkali need not be added. The mixtures are heated rapidly to from 250‹ to 300‹ C., usually until evolution of gas ceases, and the mass is then dissolved in water, and the indigo is separated from the solution in the known manner.
Patent GB-189906496-A (GB)
Title: Improvement connected with Apparatus for Poker Work.
Inventor: PALMER THEKLA
Filed: 1899-03-25
Granted: 1900-03-17
Abstract: 6496. Palmer, T. March 25. Branding by heat.-Relates to means for blowing away the smoke and gases. In Fig. 1, a represents the poker or burning-tool in its handle d connected by the tube b to the benzene bottle c, from which the gas is blown by the usual bulbsf, g and tube e. A tube i branches from the tube e by the forked connecting-piece h, and is connected to a tube or nozzle k, removably and adjustably attached to the handle d by the spring clip or partial tube l.
Patent GB-189915057-A (GB)
Title: Improvements in the Manufacture of Phonogram Duplicates.
Inventor: WOLCOTT HENRY GOODRICH
Filed: 1899-07-21
Granted: 1899-08-26
Abstract: 15,057. Wolcott, H. G. July 21. Phonographs.- Duplicates of phonogram records are obtained by expanding a plastic cylinder a of vulcanite or celluloid, inside an electronegative b of the original record. The plunger e fitting the cylinder a is drilled and recessed to allow the sleeve d to be expanded by compressing air or liquid in the hollow parts of the plunger. Either or both the cylinder a and negative b may be heated before assembling. c is a strong housing for the negative.
Patent GB-189917947-A (GB)
Title: Improvements in Flap Valves.
Inventor: KAHLSON GUNNAR FRITHIOF
Filed: 1899-09-05
Granted: 1899-11-04
Abstract: 17,947. Kahlson, G. F. Sept. 5. Hinged valves.- A flap valve a is suspended from brackets d, by projections b from a prolongation c of the casing, so as to press lightly on its seat. A cover e serves to facilitate repairs and retain the projections b in place.
Patent GB-189918405-A (GB)
Title: An Improved Stop Watch for Use in Counting the Beats of the Human Pulse.
Inventor: DELDEN JOHANN FRIEDRICH VAN
Filed: 1899-09-12
Granted: 1899-11-11
Abstract: 18,405. Delden, J. F. van. Sept. 12. Chronographs.- Relates to stop-watches for counting pulse-beats. The watch has one hand only, rotating in one minute, and driven by a spring in the barrel b which can be wound up by a very few turns of the knob c. The wheel d is normally engaged by a stop-pawl which can be released by pressing the stud e.
Patent GB-189918569-A (GB)
Title: Improvements in or relating to Illuminating Projectiles.
Inventor: TOCCACELI TITO
Filed: 1899-09-14
Granted: 1900-08-18
Abstract: 18,569. Toccaceli, T. Sept. 14. Lighting large areas, systems of.-Relates to illuminating projectiles such as those used in warfare to ascertain the position of the enemy. Cases M, Fig. 5, containing a mixture of magnesium, barium nitrate, and sulphur, or other illuminating material at the one end, and a parachute at the other, are enclosed in a metal or other casing 0 provided with a fuze on its surface. The casing 0 is then covered with fabric or its equivalent Q, Fig. 7, and placed in the shell A, a space R being left for the insertion of deadening-material. A time fuze placed in the head F of the shell A communicates through a tube B with the powder charge in a recess E formed between the plug D and the diaphragm C. This diaphragm, as shown in Fig. 2, is provided with perforations G, a handle H, two lugs I for locking it to the shell A, and a slot K for completing the communication between the tube B and the recess E.