baber/WOPTO huggingface dataset:
Patent CA-3175392-A1 (CA)
Title: Cellules modifiees par un recepteur d'antigene chimerique ciblant flt3 pour le traitement de malignites positives a flt3
Inventor: CALIGIURI MICHAEL A
IPC: A61K39/00
Filed: 2021-04-16
Abstract: La présente invention concerne des compositions comprenant une population de cellules autologues ou allogéniques transduites par une molécule d'acide nucléique codant pour un récepteur d'antigène chimère (CAR) qui reconnaît et se lie spécifiquement à la tyrosine kinase 3 de type FMS (FLT3), des procédés de préparation de formulation de ces cellules exprimant CAR et des procédés d'utilisation en tant qu'agents anticancéreux.
Patent CA-3175699-A1 (CA)
Title: Magnetic flooring system and magnetic clip for use therewith
Inventor: KLEIN MATTHEW PETER
IPC: F16B5/12
Filed: 2017-05-12
Abstract: A flooring system includes a first ferromagnetic device affixed to an upper surface of a floor joist and a flooring piece having a slot formed along an undersurface and running lengthwise along the flooring piece. A second ferromagnetic device is within the slot, and a magnetic mounting clip has an inverted U-shape and flat upper surface and two opposing legs forming an open bottom. The first ferromagnetic device and the second ferromagnetic device in combination possess an attractive magnetic property pulling each toward one another. The flooring piece is positioned over and across the floor joist such that the second ferromagnetic device is adjacent the first ferromagnetic device and the attractive magnetic property between the ferromagnetic devices magnetically bonds the flooring piece to the flooring joist. The first ferromagnetic device is affixed to the upper surface of the floor joist utilizing the magnetic mounting clip mounted on the floor joist.
Patent CA-3175808-A1 (CA)
Inventor: TETRICK JOSHUA
IPC: A23L27/60
Filed: 2012-11-02
Abstract: Disclosed herein are non-egg compositions that can be used as egg substitutes.  The disclosure is directed to egg substitutes and methods of manufacturing the same, and compositions comprising the egg substitutes, including edible compositions such as baked goods and edible emulsions.
Patent CA-3176627-A1 (CA)
Title: Poly alpha-olefin compositions and processes to produce poly alpha-olefins
Inventor: LI MARK H
IPC: C10G69/12
Filed: 2021-04-28
Abstract: The present disclosure relates to processes to produce a poly alpha-olefin (PAO) composition. In some embodiments, a process includes introducing a first C6-C32 alpha-olefin, a second C6-C32 alpha-olefin different than the first C6-C32 alpha-olefin, and a first catalyst system comprising an activator and a metallocene compound into a first reactor, wherein a molar ratio of the first C6-C32 alpha-olefin to the second C6-C32 alpha-olefin is from about 1:5 to about 5:1, by total moles of the first and second C6-C32 alpha-olefin; obtaining a first effluent including a PAO dimer; introducing the first effluent, a third C6-C32 alpha-olefin, and a second catalyst system to an oligomerization unit, wherein the third C6-C32 alpha-olefin is the same or different than the first C6-C32 alpha-olefin and/or second C6-C32 alpha-olefin; obtaining a second effluent; and hydrogenating the second effluent to form the PAO composition.
Patent CA-3179802-A1 (CA)
Title: Electroceutical dressing for wound care
Inventor: PRAKASH SHAURYA
IPC: A61N1/06
Filed: 2021-04-08
Abstract: Electroceutical dressings having at least three electrodes that are used for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.
Patent CA-3180574-A1 (CA)
Inventor: O'CONNOR MAUREEN D
IPC: A61K47/68
Filed: 2021-06-11
Abstract: There are provided tetravalent TGF? receptor-ectodomain based traps having a tailored isoform-specificity profile for neutralization of TGF? ligands, and methods of use thereof in the treatment of diseases and conditions associated with TGF?, particularly TGF?1 and TGF?3. In particular, there are provided TGF? binding agents designed to tailor TGF? isoform specificity, in order to maximize therapeutic efficacy in specific disease indications while minimizing adverse effects. The TGF? binding agents comprise two polypeptides assembled via a multimerization domain, each polypeptide having two TGF?II receptor (TGF?R) ligand-binding domains linked as a doublet, wherein the linkers are selected to tailor isoform specificity.
Patent CA-3181318-A1 (CA)
Title: Application de compositions de coloration des cheveux
Inventor: ATTAL YVES
IPC: A45D19/02
Filed: 2021-06-07
Abstract: L'invention concerne un dispositif d'application pour appliquer une composition de coloration des cheveux, comprenant un corps de dispositif, comprenant un premier réservoir comprenant un premier piston ; le premier réservoir étant conçu pour recevoir une première partie d'une composition de coloration des cheveux ; un deuxième réservoir comprenant un deuxième piston ; le deuxième réservoir étant conçu pour recevoir une deuxième partie d'une composition de coloration des cheveux ; et un mécanisme de distribution associé au premier piston et au deuxième piston ; le mécanisme de distribution étant conçu pour déplacer de manière étanche le premier piston à l'intérieur du premier réservoir et le deuxième piston à l'intérieur du deuxième réservoir ; et un capuchon d'application, comprenant un mécanisme de mélange ; et une pluralité de pointes saillantes ; le capuchon d'application étant conçu pour une liaison réversible avec le corps de dispositif de telle sorte que, lorsque le capuchon d'application est relié au corps de dispositif, le premier réservoir et le deuxième réservoir sont fermés de manière étanche par rapport à l'extérieur à l'exception des canaux de la pluralité de pointes saillantes qui sont en communication fluidique avec le premier réservoir et le deuxième réservoir, par l'intermédiaire du mécanisme de mélange ; et le mécanisme de distribution étant conçu, lorsqu'il est activé, pour déplacer le premier piston et le deuxième piston vers la pluralité de pointes saillantes, ce qui permet de mélanger la première partie de la composition de coloration des cheveux avec la deuxième partie de la composition de coloration des cheveux pour former une composition mélangée de coloration des cheveux à distribuer à travers la pluralité de dents saillantes.
Patent CA-3183841-A1 (CA)
Title: Systeme de detection de reseau d'antennes
Inventor: BAYRAM YAKUP
IPC: F41C27/00
Filed: 2020-06-30
Abstract: La présente invention concerne un système de détection permettant d'évaluer et de surveiller l'état d'un matériau faisant partie d'un four réfractaire, intégrant une antenne et une structure de réseau qui pourrait faire partie du four. Le système peut fonctionner pour identifier des défauts et pour mesurer le profil d'érosion et l'épaisseur de différents matériaux, y compris des matériaux réfractaires d'un four industriel, à l'aide de signaux radiofréquence. Le système est conçu pour intégrer l'antenne ayant un réseau adjacent à une paroi de four externe pour améliorer les performances globales du système de détection par comparaison avec celles de l'antenne seule pendant une inspection du four, même dans des régions d'accès difficile. En outre, le système comprend un mécanisme pour fixer physiquement l'antenne au réseau de four ou pour modifier la configuration de réseau autour de l'antenne pour améliorer les performances du système pour mieux estimer la durée de vie fonctionnelle restante et le plan de maintenance du four.
Patent CA-3184027-A1 (CA)
Inventor: POSTEL RUBEN
IPC: A61K47/68
Filed: 2021-06-23
Abstract: The invention relates to a saponin derivative based on a saponin comprising a triterpene aglycone and a first saccharide chain and/or a second saccharide chain, and comprising: an aglycone core structure comprising an aldehyde group which has been derivatised; and/or the first saccharide chain wherein the first saccharide chain comprises a carboxyl group, which has been derivatised; and/or the second saccharide chain wherein the second saccharide chain comprises at least one acetoxy group which has been derivatised. The invention also relates to a first pharmaceutical composition comprising the saponin derivative of the invention. In addition, the invention relates to a pharmaceutical combination comprising the first pharmaceutical composition of the invention and a second pharmaceutical composition comprising any one or more of an antibody-toxin conjugate, a receptor-ligand ? toxin conjugate, an antibody-drug conjugate, a receptor-ligand ? drug conjugate, an antibody-oligonucleotide conjugate or a receptor-ligand ? oligonucleotide conjugate. The invention also relates to the first pharmaceutical composition or the pharmaceutical combination of the invention, for use as a medicament, or use in the treatment or prophylaxis of a cancer, an infectious disease, viral infection, hypercholesterolemia, primary hyperoxaluria, haemophilia A, haemophilia B, alpha-1 antitrypsin related liver disease, acute hepatic porphyria, transthyretin-mediated amyloidosis, or an auto-immune disease. Furthermore, the invention relates to an in vitro or ex vivo method for transferring a molecule from outside a cell to inside said cell, comprising contacting said cell with the molecule and with a saponin derivative of the invention.
Patent CA-3184408-A1 (CA)
Inventor: TAMIR MICHAEL
IPC: G06T17/00
Filed: 2021-03-10
Abstract: A method and system for improving a three-dimensional (3D) representation of objects using semantic data. The method comprises receiving an input data generated in response to captured video in a filming area; setting at least one parameter for each region in the input data; and generating a 3D representation based in part on the at least one parameter and semantic data associated with the input data.
Patent CA-3186728-A1 (CA)
Inventor: DAVIS SIMON JOHN
IPC: A61P35/00
Filed: 2021-06-11
Abstract: This invention relates generally to antibodies that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders. Suitably, the antibodies also possess an Fc modification that enhances signalling through Fc?R2B.
Patent CA-3193906-A1 (CA)
Inventor: WU JINZI JASON
IPC: C07F9/6571
Filed: 2020-09-30
Abstract: A crystal of a thyroid hormone ß receptor agonist, a preparation method therefor and use thereof. The crystal has substantially no hygroscopicity, and has a smaller crystal particle size and a larger drug specific surface area, so that the dissolution rate of the drug can be increased, the absorption of the drug is facilitated, and the bioavailability is improved.
Patent CA-3195749-A1 (CA)
Title: Method of and system for in vivo strain mapping of an aortic dissection
Inventor: FORNERIS ARIANNA
IPC: G16H30/40
Filed: 2022-02-03
Abstract: There is provided a method and a system for generating a strain map of a dissected blood vessel. A multiphase stack of the dissected blood vessel is received, a given phase of the multiphase stack representing the blood vessel at a given time in a cardiac cycle. A 3D geometrical model of the blood vessel comprising a wall of the blood vessel and a dissection flap is generated. A surface mesh of the blood vessel for a first phase is generated, the surface mesh comprising a blood vessel wall surface mesh and a dissection flap surface mesh. A local deformation at each phase is determined by mapping voxels of the surface mesh of the blood vessel to the multiphase stack. A strain map including principal strain values is generated using the local deformation and the blood vessel wall surface mesh and the dissection flap surface mesh.
Patent CA-3199225-A1 (CA)
Inventor: VALOIS PATRICK
IPC: F02C9/00
Filed: 2023-05-11
Abstract: A method is provided for an engine. During this method, a database is provided for a parameter of the engine. The database includes a plurality of values for the parameter determined over a period of time. Confidence bands are established using a probability density function on the database. An action is performed in response to a comparison of a first updated value for the parameter to the confidence bands. The engine may be configured as a gas turbine engine or another type of heat engine.
Patent CA-3200758-A1 (CA)
Title: Derives de 4-(pyrazol-5-yl)-indole macrocycliques ramifies utilises en tant qu'inhibiteurs de mcl-1
Inventor: ROMBOUTS FREDERIK JAN RITA
IPC: C07D498/22
Filed: 2021-12-16
Abstract: La présente invention concerne des agents pharmaceutiques de formule (I) utiles pour la thérapie et/ou la prophylaxie chez un sujet, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs de MCL-1, utiles pour le traitement de maladies telles que le cancer.
Patent CA-3201029-A1 (CA)
Title: Ball float vent valve
Inventor: O'NEILL WILLIAM N
IPC: F16K24/04
Filed: 2021-11-30
Abstract: A ball float vent valve (30) for a hydraulic system (10) of a work machine (1) includes a valve body (32) having an inlet port (34), an outlet port (36) and an axial passageway (38) there-between. The passageway (38) may be defined by a cylindrical inlet chamber (40), a cylindrical outlet chamber (42) and a tapered seat (44) connecting the inlet chamber (40) and outlet chamber (42). The outlet chamber (42) may include an annular retaining groove (48) proximate the outlet port (36). A spherical float (46) may be positioned in the outlet chamber (42). The float (46) may be dimensioned to seal the passageway (38) when seated on the tapered seat (44). A retainer (50) positioned in the retaining groove (48) may include an outer crescent region (54) having a plurality of apertures (52), a center region (56) dimensioned to retain the float (46) in the outlet chamber (42), and a linking region (58) connecting the outer region (54) to the center region (56).
Patent CA-3201269-A1 (CA)
Title: Guide element for hydraulic fluid
Inventor: WEAR DANIEL GREGORY
IPC: F15B21/041
Filed: 2021-12-13
Abstract: A guide element for hydraulic fluid includes a first end surface, a second end surface, and an exterior surface connecting the first end surface to the second end surface. The first end surface includes a first chamfered opening. The second end surface includes a second opening that fluidly communicates with the first opening to define a longitudinal bore that includes a tapered section. The first chamfered opening and the tapered section are configured to guide the hydraulic fluid to facilitate transformation of a turbulent flow of the hydraulic fluid into a laminar flow of the hydraulic fluid.
Patent CA-3203234-A1 (CA)
Inventor: MASUD MUHAMMAD
IPC: G16H80/00
Filed: 2021-12-14
Abstract: This application relates to apparatus and methods for automatically determining medical professional assignments to provide medical care. In some examples, a computing device receives a case alert for a case for a facility, and determines a plurality of physicians credentialed at the facility. The computing device determines an availability status of each of the physicians based on an availability schedule, and further determines a credentialing index for each of the physicians. Each credentialing index can be based on a forecasted demand of each of a plurality of facilities that each of the physicians is credentialed for. The computing device determines one of the physicians based on the availability status and the credentialing index of each of the plurality of physicians. The computing device then generates a case request for the case for the first physician, and transmits the case request for assignment.
Patent CA-3203941-A1 (CA)
Inventor: KROPF DANIEL
IPC: A24F1/30
Filed: 2022-03-09
Abstract: The invention relates to a set for protecting a water pipe (1) against breakage and/or damage in the event of overturning, which water pipe (1) has a mouthpiece (3) and a chillum (10).  In order to be able to obtain optimal protection of water pipes (1) of the most diverse shapes despite a simple attachment while simultaneously achieving a small space requirement, it is provided according to the invention that a set comprises a mouthpiece element (4) and a chillum element (9) which are, at least in some regions, formed from a more elastic material than the water pipe (1), in particular a more elastic material than glass, and which each comprise an opening and can be releasably attached to the water pipe (1) in that the mouthpiece (3) is introduced into the opening (5a) of the mouthpiece element (4) and the chillum (10) is introduced into the opening (5b) of the chillum element (9).  The invention furthermore relates to a water pipe (1) having a mouthpiece (3) and a chillum (10) as well as a set for protecting the water pipe (1) against breakage and/or damage in the event of overturning.  Additionally, the invention relates to a use of a set for protecting a water pipe (1) against breakage and/or damage in the event of overturning.
Patent CA-3205330-A1 (CA)
Inventor: KURSTJENS MICHEL ANTOIN MARIE
IPC: B21D3/10
Filed: 2022-01-18
Abstract: Method for forming tubular segments, wherein a metal strip is or a series of metal strips is pressed into a tubular or truncated conical shape, such that opposite longitudinal ends of the strip or strips meet, forming at least one seam, where after the seam is welded, joining the meeting ends together, wherein at least after welding the cross sectional profile of at least part of the segment is measured, at least at and/or near said welded seam or seams, and data of said measurement is fed into a control unit, where after a press is operated by the control unit based on said data, adjusting the cross sectional profile of the segment, at least at the or each seam.
Patent CA-3205553-A1 (CA)
Inventor: SAND THEODORE T
IPC: A61L27/38
Filed: 2022-01-18
Abstract: Sont divulgués de nouveaux procédés de traitement de tissu reproducteur, à partir, par exemple, de procédures de stérilisation et de castration, pour optimiser le rendement et la viabilité des cellules d'une manière convenant à l'obtention de multiples doses thérapeutiques requises typiquement pour des applications cliniques. Par exemple, sont divulgués de nouveaux procédés de digestion, d'agitation et d'incubation de tissus reproducteurs et de fractions de ceux-ci, comprenant, par exemple, l'agitation mécanique réciproque et/ou par vibrations et la co-culture avec des suspensions de cellules et du tissu partiellement digéré pour améliorer la migration des cellules.
Patent CA-3205607-A1 (CA)
Inventor: KOHL THOMAS MATTHEW
IPC: C09D5/24
Filed: 2021-12-21
Abstract: La présente divulgation concerne de manière générale des revêtements et des compositions comprenant des polymères conducteurs. La présente divulgation concerne également des revêtements et des compositions thermostables comprenant des polymères conducteurs de polyaniline pouvant être traités en solution et des agents de stabilité thermique, ainsi que des procédés de préparation des revêtements et des compositions.
Patent CA-3208620-A1 (CA)
Inventor: AXELROD GLEN S
IPC: A01K1/015
Filed: 2022-02-01
Abstract: L'invention concerne une compresse d'apprentissage pour animal de compagnie comprenant une région absorbante ; et une région de bordure entourant au moins une partie de la région absorbante comprenant un renfort déformable disposé à l'intérieur de la région de bordure. La région de bordure comprenant le renfort déformable est convertible d'une configuration sensiblement plate à une configuration verticale de telle sorte que la région de bordure comprenant le renfort déformable passe de la configuration sensiblement plate à la configuration verticale ; et lorsque la région de bordure comprenant le renfort déformable passe de la configuration sensiblement plate à la configuration verticale, le renfort déformable se courbe de la configuration sensiblement plate à la configuration verticale et la région de bordure forme une paroi verticale.
Patent CA-3208628-A1 (CA)
Title: Method for treating surfaces or gaseous media using a ferromagnetic gel
Inventor: GOSSARD ALBAN
IPC: G21F9/02
Filed: 2022-02-24
Abstract: Disclosed is a method for decontaminating a surface of a substrate or a method for decontaminating a gaseous medium using an inorganic ferromagnetic gel consisting of a colloidal solution comprising an inorganic thickening agent, a ferromagnetic compound and a solvent.
Patent CA-3210162-A1 (CA)
Inventor: PECORA ANDREW L
IPC: G16H10/60
Filed: 2014-10-06
Abstract: The described invention provides a system and method for clinical outcome tracking and analysis.  The clinical outcome tracking and analysis comprises sorting, outcome tracking, quality of life metrics, toxicity to therapy and cost of care. The system and method includes receiving one or more parameters. Exemplary parameters for sorting include sex, age, ethnicity, comorbidities, tobacco use, source of insurance, medical record number, primary care physician, referring physician, hospital, approved service vendors, disease-specific clinical molecular phenotype, therapy intent, stage of therapy, biomarkers, and cost of care.
Patent CA-3211905-A1 (CA)
Inventor: MORENO BROCINER MANUEL JOSE
IPC: B65D39/08
Filed: 2022-03-14
Abstract: A closure system including a cap and a spout, where the cap and/or spout contain at least one discrete layer of barrier material. In one example, the spout includes a conduit and a seal member, the conduit being arranged about an imaginary axis and the seal member having one or more surfaces configured to be secured to a container. The cap includes an inner circumferential surface, the inner circumferential surface arranged to encompass the conduit. The cap also includes a first discrete layer of thermoplastic resin and a first discrete layer of barrier material and the seal member includes a second discrete layer of thermoplastic resin and a second discrete layer of barrier material.
Patent CA-3214124-A1 (CA)
Inventor: PAPADACCI CLEMENT
IPC: A61B8/08
Filed: 2022-04-01
Abstract: While 3D ultrasound imaging is becoming a powerful tool in medical field, the main drawback is the difficulty to image large 3D volume, mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers, wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart, with high resolution and high sensitivity.
Patent CA-3214664-A1 (CA)
Inventor: BALLMER STEVEN G
IPC: C07D217/16
Filed: 2022-04-07
Abstract: La présente invention concerne de nouveaux procédés de préparation de composés analogues de la rapamycine, ainsi que des intermédiaires associés utiles dans lesdits procédés.
Patent CA-3216639-A1 (CA)
Inventor: CANGIOLI FRANCESCO
IPC: F04D17/12
Filed: 2022-04-25
Abstract: L'invention concerne un rotor comportant une pluralité de segments de rotor disposés de manière à être axialement adjacents les uns aux autres. Un tirant s'étend à travers les segments de rotor. Des premier et second éléments de verrouillage opposés disposés aux extrémités axiales du tirant verrouillent les segments de rotor les uns sur les autres et sur le tirant. Au moins un élément de soutien intermédiaire est disposé dans une position intermédiaire entre les deux extrémités axiales du tirant et entre le tirant et un des segments de rotor.