baber/WOPTO huggingface dataset:
Patent EA-004471-B1 (EA)
Title: Method for preparing <13>c-urea from <13>co2
Inventor: SKORNYAKOV YURY VLADIMIROVICH
IPC: C07C273/02
Filed: 2000-06-08
Abstract: 1. Method of preparation of tagged on carbon <13>C-urea, characterized in that the solution of bis (trialkylsilyl) amide metal in organic solvent is subjected to treatment of <13>C- dioxide carbon with resulting of tagged on carbon <13>C-bis-(trialkylsilyl) carbodiimide and following aqueous hydrolyze. 2. Method according to claim 1, characterized in that the intermediately forming <13>C-bis-(trialkylsilyl)carbodiimide is separated by filtering, concentration by evaporation and rectification at decreased level of pressure. 3. Method according to claim 2, characterized in that the rectification is realized at the pressure of 10-25 mm of mercury column. 4. Method according to claim 1, characterized in that aqueous hydrolyze is realized in presence of acid and organic solvent. 5. Method according to claim 1, characterized in that metal hexamethyldisilazide is used as <13>C-bis-(trialkylsilyl)carbodiimide, <13>C-bis - dioxide carbon and metal hexamethyldisilazide is taken in stereometric ratio or 1:1. 6. Method according to claim 1, characterized by using of alkaline metal hexamethyldisilazide. 7. Method according to claim 6, characterized in that lithium or sodium hexamethyldisilazide is used as alkaline metal hexamethyldisilazide.
Patent EA-004470-B1 (EA)
Title: A crystalline form of celecoxib
Inventor: GUNDUZ A HALIT
IPC: C07D231/12
Filed: 2001-06-26
Abstract: 1. Crystalline 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, characterised by at least the following X-ray powder diffractogram reflexes: Angle [ degree 2theta]   Rel.int. [%] 14.800  69.0 16.050  78.9 17.875  63.7 195  100.0 21.455  96.6 22.080  68.1 22.385  65.4 23  62.5 25.330  64.5 29.355  60.8 2. The crystallin-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide according to claim 1, characterised by at least the following further X-ray powder diffractogram reflexes: Angle [ degree 2theta] Rel. int. [%] 10.670  33.4 10.970  34.0 12.5  32.4 13.855  17.5 18.340  40.4 18.685  40.0 20.19.1 20.670  19.0 23.185  48.7 24.510  37.8 24.930.5 25.730  22.8 26.915  23.1 27.630  31.5 28.185   29.955  32.7 30.375  9.9 31.405  9.6 34.915  15.7585  10.9 37.895  17.9 44.070  9.4 45.250  14.5 3.stalline 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, especially according to claim 1 or 2, characterised in that it has a tap density of not less than 0.360 g/ml, and/or a bulk density of not less than 0.270 g/ml. 4. A method for the production of the crystalline substance according to any one of claims 1 to 3, characterised in that 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione is reacted with 4-sulphonamidophenylhydrazine hydrochloride in a suitable solvent, the resulting 4-[5-(methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide is crystallized from the reaction mixture and is recrystallized from the group of N,N-dimethylformamide, N,N-dimethylacetamide and a mixture thereof by the addition of a nonsolvent, especially water. 5. The method according to claim 4, characterised in that the reaction is carried out in isopropanol. 6. The method according to any one of claims 4 or 5, characterised in that 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide is crystallized from the reaction mixture by the addition of a nonsolvent, especially water. 7. The method according to any one of claims 4 to 6, characterised in that 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide is recrystallized at a temperature between 0 degree C and 80 degree C. 8. Crystalline 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide in accordance with claims 1, 2 or 3, obtainable by the method of any one of claims 4 to 7. 9. A pharmaceutical preparation, comprising crystalline 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide in accordance with any one of claims 1, 2, 3 or 8. 10. The pharmaceutical preparation, comprising crystalline 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide obtainable by the method of any one of claims 4 to 7.
Patent EA-009545-B1 (EA)
Title: Auxiliary power unit intake duct with aero-acoustic guide vanes
Inventor: HERNANZ-MANRIQUE JOSE-ANGEL
IPC: B64D33/02
Filed: 2005-12-30
Abstract: An auxiliary power unit intake duct with aero-acoustic guide vanes for an aircraft, the intake duct (1) comprising an internal straight portion (1a), an internal first bend portion (1b) and an internal second bend portion (1c), said internal portions (1a,1b,1c) extending between a duct air inlet (2) and a plenum entry (3) of the auxiliary power unit, a plurality of acoustic guides vanes (4,5) located in said straight portion (1a) of the intake duct (1), said acoustic guide vanes (4,5) extending horizontally between opposite side portions of said straight portion (1a); and a plurality of curved aerodynamic guide vanes (6,7) located in said second bend portion (1c) proximate to said plenum inlet (3), said curved aerodynamic guide vanes (6,7) extending vertically between a top portion and a bottom portion of said second bend portion (1c); each of said curved aerodynamic guide vanes (6,7) being concentric with said bend curvature of said second bend portion (1c).
Patent EA-008771-B1 (EA)
Title: Microcapsules loaded with active ingredients and a method for their preparation
Inventor: NAIGERTSIK OLED
IPC: A23L27/00
Filed: 2004-08-01
Abstract: The invention relates to microcapsules having a core material encapsulated within a microcapsular shell, the core material comprises at least one active ingredient, wherein the microcapsular shell comprises at least one inorganic polymer comprising polymerized precursors obtained by in-situ polymerization of the precursors; wherein the concentration of the core material based total weight of the microcapsules is above 95% w/w. The invention further relates to a composition and to a suspension comprising the microcapsules. The invention additionally relates to a process for preparing the microcapsules.
Patent EA-010175-B1 (EA)
Title: Switching circuit which is used to obtain a double dynamic range
Inventor: BLASCO CLARET JORGE VINCENTE
IPC: H03K17/687
Filed: 2005-10-26
Abstract: The invention relates to a switching circuit which is used to obtain a doubled dynamic range. According to the invention, using a transistor, the invention can be used to switch signals with a peak level equal to the supply voltage, said peak-to-peak level being twice the supply. The invention is characterised in that a transistor (17) is connected to the signal source (10) and a load (19) by means of a series of capacitors (11, 18), resistors (15, 16) and an inductor (12) which form the inventive circuit. The invention is also characterised in that two complementary control voltages (13 and 14) are applied in order to control the cut-off and conduction states of the switching circuit.
Patent EA-011229-B1 (EA)
Title: Formulation for prophylaxis of oral cavity diseases
Inventor: MANASHEROV TAMAZI OMAROVICH
IPC: A61K6/00
Filed: 2005-11-25
Abstract: The invention relates to medicine, namely, to stomatology, in particular, to formulation for prophylaxis of oral cavity diseases. The formulation comprises: drinking water, glycerol, xylitol, silica, xanthan gum, methylparaben, propylparaben, titanium dioxide, perfume, bromelain, sodium saccharin, sodium lauryl sulfate or alkylamidobetain, calcium glycerophosphate, and magnesium chloride or glycerophosphate magnesium at a definite following component ratio. The formulation provides better cleaning of teeth and their mineralization, as well as enhanced enamel resistivity and reduced inflammatory phenomena in periodontium.
Patent EA-009487-B1 (EA)
Title: Method for cleaning the ballast of a track
Inventor: THEURER JOSEF
IPC: E01B27/06
Filed: 2005-01-17
Abstract: In order to clean the ballast, the rails (23) of a track (8) are separated and lifted, and a transversal strand (9) of a cleaning chain (7), extending normally to a machine longitudinal direction, is positioned beneath the track (8). To this end, prior to this, a rail undercarriage (4) arranged directly upstream of the cleaning chain (7) in the working direction (19) is lifted from the track, and is then repositioned on the track (8) for work.
Patent EA-014293-B1 (EA)
Title: Macrocyclic inhibitors of hepatitus c virus
Inventor: RABOISSON PIERRE JEAN-MARIE BERNARD
IPC: A61K31/4523
Filed: 2006-07-28
Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by ------) represents an optional double bond; X is N, CH and where X bears a double bond it is C; Ris –OR, -NH-SOR; Ris hydrogen, and where X is C or CH, Rmay also be Calkyl; Ris hydrogen, Calkyl, Calkoxy Calkyl, or Ccycloalkyl; n is 3, 4, 5, or 6; Rand Rindependently from one another are hydrogen, halo, hydroxy, nitro, cyano, carboxyl, Calkyl, Calkoxy, Calkoxy Calkyl, Calkylcarbonyl, Calkoxy- carbonyl, amino, azido, mercapto, Calkylthio, polyhalo Calkyl, aryl or Het; W is aryl or Het; Ris hydrogen; aryl; Het; Ccycloalkyl optionally substituted with Calkyl; or Calkyl optionally substituted with Ccycloalkyl, aryl or with Het; Ris aryl; Het; Ccycloalkyl optionally substituted with Calkyl; or Calkyl optionally substituted with Ccycloalkyl, aryl or with Het; aryl is phenyl or naphthyl, each optionally substituted with 1-3 substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 - 4 heteroatoms each independently selected from N, O or S, and optionally substituted with 1 -3 substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
Patent EA-013314-B1 (EA)
Title: Method of fermenting wort
Inventor: BANKS DOUGLAS JOHN
IPC: C12C11/00
Filed: 2007-05-14
Abstract: The present invention relates to a continuous method of fermenting wort, said method comprising: - fermenting wort with a biologically active yeast to produce an alcohol containing fermented liquid; - introducing the fermented liquid containing at least 10 g/l of biologically active yeast into a maturation vessel; - separately removing yeast containing sediment and supernatant liquid from the vessel; and - optionally recirculating at least a part of the yeast containing sediment to the wort fermentation; wherein the residence time of the fermented liquid in the maturation vessel exceeds 6 hours. The present method offers the advantage that it combines maturation and yeast separation into one processing step, whereas conventional continuous processes require at least two separate processing steps, one for yeast separation and one for maturation. Secondly, the present method is very robust as the relatively high residence time that is needed for maturation ensures that effective sedimentation is achieved under virtually all conditions.
Patent EA-017448-B1 (EA)
Title: 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
Inventor: PHADKE AVINASH
IPC: A61K38/00
Filed: 2007-07-13
Abstract: The invention provides 4-amino-4-oxobutanoyl peptides of formula (I)and pharmaceutically acceptable salts and hydrates thereof. The variables R-R, R, R, R, n, M, Y and Z are defined herein. Certain compounds of formula (I) are useful as an antiviral agents. Certain 4-amino-4-oxobutanoyl peptide compounds disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain 4-amino-4-oxobutanoyl peptide compound as the only active agents or may contain a combination of 4-amino-4-oxobutanoyl peptide compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.
Patent EA-015647-B1 (EA)
Title: Pyrido-pyrazine derivatives useful as herbicidal compounds
Inventor: CARTER NEIL BRIAN
IPC: A01N43/90
Filed: 2007-12-06
Abstract: The present invention relates to compounds of formula (I): wherein R, R, R, Rand Rare as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to methods of controlling plants and compositions comprising compounds of formula (I).
Patent EA-015163-B1 (EA)
Title: Transformer
Inventor: HANSEN VOLKER W
IPC: H01F27/28
Filed: 2008-02-01
Abstract: A transformer (10) with an insulation arrangement between a high voltage winding (4) and a low voltage winding (8) for potential isolation, or an insulation arrangement for potential isolation between a high voltage winding (4) and a low voltage winding (8) of a transformer, has a layered structure, comprising inner insulation (2; 2a, 2b) between the high voltage winding (4) and the low voltage winding (8), which are adjoined by at least one semiconductive layer (6, 6a, 6b). In this way, the dimensions of a transformer can be reduced, and, in addition, partial discharges towards the outside can be reduced or entirely suppressed.
Patent EA-015222-B1 (EA)
Title: Method for the production of hot-finished seamless pipes having optimized fatigue properties in the welded state
Inventor: RING MARKUS
IPC: B21J5/08
Filed: 2008-06-26
Abstract: The invention relates to a method for the production of hot-finished, particularly hot-rolled, seamless pipes having optimized fatigue properties in the welded state, having an outside diameter of up to 711 mm and a nominal wall thickness of up to 100 mm, made of metal, in particular steel. After hot or finish rolling, a defined pipe cross-section is produced on at least one pipe end across a predetermined length, having tight tolerances for inside and outside diameters, wherein the cross-section can then be welded to the pipe end of another pipe. According to the invention, in a region a wall thickness is created in a first step at the pipe end in question, the thickness being bigger than on the remaining pipe body, wherein the outside diameter is increased and/or the inside diameter is reduced. In a second step, the required pipe cross-section is produced in said region by mechanical machining, and the transition from the machined to the unmachined region of the pipe is produced with low surface roughness and almost notch-free, and the residual wall thickness remaining in the machining region is within the required tolerances.
Patent EA-016571-B1 (EA)
Title: Method for automated fuel leakage detection during reloading of reactor fuel assembly and system therefor
Inventor: FEDOSOVSKIJ MIKHAIL EVGENIEVICH
IPC: G21C17/07
Filed: 2010-10-06
Abstract: The present invention relates to nuclear power reactors and can be used in operation of reactors with liquid heat transfer medium, such a water. A method for fuel leakage detection of the fuel assemblies during nuclear fuel reloading in a reactor with heat transfer liquid, wherein the fuel assembly transport device is installed in position to remove the fuel assembly; the fuel assembly is placed into the fuel assembly transport device; during placing the fuel assembly into the transport device, the sampling of a gas sample at least one point in a volume above the surface of heat transfer liquid within the fuel assembly transport device is commenced; while gas is supplied under the fuel assembly, and said gas is passed through the heat transfer liquid; β- and γ-activity of the sample are analyzed, and the resulting sample analysis values are recorded; the preliminary fuel assembly tightness is determined; all of the aforementioned actions are performed sequentially for each subsequent fuel assembly reloading; the statistical processing of all analytical results pertaining to samples from all fuel assemblies is carried out, and a conclusion regarding the tightness of each fuel assembly is reached based thereupon; wherein the overall background β- and γ-activity is determined prior to commencing reloading; the supply of gas under the fuel assembly is stopped prior to commencing horizontal transport of the fuel assembly; and during the preliminary fuel assembly leakage detection, the background β- and γ-activity determined immediately prior to placing the fuel assembly into the transport device and overall β- and γ-activity measured prior to commencing reloading are taken into account, and the preliminary fuel assembly leakage detection result is output.
Patent EA-017627-B1 (EA)
Title: Quinuclidine derivatives as muscarinic m3 receptor antagonists
Inventor: FORD RHONAN LEE
IPC: A61K31/439
Filed: 2008-05-13
Abstract: The invention provides named compounds of general structural formula (I), wherein Ris tien-2-yl or phenyl optionally substituted by a fluorine atom, Ris a substituted 1-azabicyclo[2.2.2]octane comprising pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
Patent EA-018816-B1 (EA)
Title: Methods of perforation using viscoelastic surfactant fluids and associated compositions
Inventor: SAMUEL MATHEW
IPC: E21B43/119
Filed: 2008-11-26
Abstract: The invention provides a method for perforating a well with a perforating fluid comprising a viscoelastic surfactant that essentially stops fluid leak-off after perforation in an overbalanced condition. Another aspect of the invention provides the perforating fluid in itself. The well has a wellbore defined by a generally cylindrical casing in at least a portion of the wellbore (i.e., the wellbore is cased, although it is not necessary cased in its entire length). The wellbore passes through a subterranean formation that comprises hydrocarbon formation fluids (such as oil and/or gas), at least in certain strata. The method comprises placing a perforating device in a wellbore which includes at least one explosive perforating charge that can be detonated in order to perforate the casing and allow the formation fluids to enter the wellbore. The casing is located between the subterranean formation and the perforating device. A perforating fluid including at least one viscoelastic surfactant is placed in the wellbore between the perforating device and the casing, in at least a portion of the wellbore. In other words, the perforating fluid is present in the wellbore adjacent to the perforating device. The explosive charge(s) in the perforating device is detonated, such that the perforating device forms at least one perforation in the casing that permits the flow of hydrocarbon formation fluids from the subterranean formation into the wellbore. As a result of the detonation, at least a portion of the perforating fluid is put in communication with the subterranean formation.
Patent EA-020887-B1 (EA)
Title: Triazole oxadiazoles derivatives
Inventor: QUATTROPANI ANNA
IPC: A61K31/4245
Filed: 2008-12-17
Abstract: The invention relates to compounds of formula (I)wherein R, R, Rhave the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
Patent EA-021616-B1 (EA)
Title: Gasification of combustible organic materials
Inventor: GALLEY DAVID
IPC: C10J3/57
Filed: 2009-04-08
Abstract: The invention relates to a process for manufacturing a combustible gas from solid and liquid combustible material. The process for manufacturing combustible gas having a lower calorific value at least 1 MJ/Nmcomprises the reaction of an oxidizing gas comprising steam or oxygen or COwith an organic material in contact with a molten silicate bath contained in a tank and comprises a heat input into the molten silicate, said process operating continuously, silicate being regularly discharged from the tank and batch materials being regularly introduced in order to supply the silicate bath and for preserving silicate composition substantially constant and below the limit of iron deposition. The invention also relates to a continuous industrial manufacturing glass process in which combustible gas is manufactured according to the above process.
Patent EA-019247-B1 (EA)
Title: Methods of preparing quinoline derivatives
Inventor: WILSON JO ANN
IPC: C07D215/22
Filed: 2009-11-13
Abstract: Methods of preparing a compound of formula i(1)or a pharmaceutically acceptable salt thereof, wherein Rand Rjoined together with the nitrogen atom to which they are attached form a 6-membered heterocycloalkyl group; Xis H, Br, Cl or F; Xis H, Br, Cl or F; s is 2-6; n1 is 1-2; and n2 is 1-2.
Patent EA-024797-B1 (EA)
Title: Vehicles monitoring method
Inventor: BEKMAGAMBETOV MURAT MAKHMETOVICH
IPC: G08G1/052
Filed: 2012-11-06
Abstract: The invention relates to the systems of vehicles traffic control, and can be used for their monitoring in terms of observance of drivers work-rest schedule, as well as road speed limit. The technical result is assurance of end-to-end monitoring of observance of the highway regulations at improved authenticity of breakers identification in conditions on the intensive road traffic, avoidance of overhead time expenses for the vehicles check, avoidance of the transgression data losses, and reducing time of response to them. The named result is achieved by that on a vehicle (1) a device (3) monitoring the driver work-rest schedule is installed, the device is equipped with the satellite navigation receiver, and the memory used to determine and to record the traffic parameters of the vehicle with time. The device (3) monitoring the driver work-rest schedule is equipped with Wi-Fi communication device, it provides radio exchange sessions with remote server (4) fitted with the digital regional map (6), and the recorded traffic parameters of the vehicle are saved in its data base (5), then the recorded traffic parameters of the vehicle are compared with named map, and if the driver violates the regulations the complete information thereof is recorded in the named data base (5), wherein by the named server (4) a web-site is made in Internet, where information on the safety and road regulations violation by the vehicle driver in real time mode is graphically coincided with named map (6), the road service inspector is provided with fixed or mobile computer (7) with access means for information relating the violation nature and time, using it the inspector enters the named web-site, wherein the map (8) of his responsibility zone is displayed with routes (9) and current position of vehicles breaching the regulations.
Patent EA-021498-B1 (EA)
Title: Method for supplying hot water and heating method using same
Inventor: PETIN YURY MARKOVICH
IPC: F25B30/00
Filed: 2011-10-18
Abstract: The invention relates to the use of heat pumps for supplying hot water and for heating apartment houses and production premises. The method for supplying hot water comprises supplying water to a heat pump circuit, heating said water to a standard temperature with the aid of heat pumps and delivering the heated water to consumers. According to the invention a consecutive heating stage is provided with a heat pump cycle similar to a triangular Lorentz cycle, selecting the temperature of the water supplied for heating in the first stage heat pump, and adjusting each heat pump to the condensation temperature of the working fluid thereof at which heat Qgiven off by said stage meets the requirement: Q=1/n×Q, wherein i is a serial number of a heating stage; Qis total heat from all heating stages at the exit of the last stage; n is a number of heating stages. Also provided is a heating method using said heat water supply method. The invention provides to increase the technical and economic efficiency due to organization of staged water heating using a heat pump cycle maximum approached to a triangular Lorentz cycle.