Patent GB-818425-A (GB)
Title: Improvements in the production of cosmetic, therapeutic and growth factor substancesin powder form
IPC: A61K47/34
Filed: 1956-12-21
Abstract: Therapeutic, cosmetic or growth-factor substances in powder form are made by drying and hardening a foam obtained from an aqueous solution of an aminoplast or phenoplast containing a therapeutic, cosmetic or growth-factor substance and grinding the hardened foam.  Specified aminoplasts and phenoplasts are derived from urea, thiourea, biuret, aminotriazines containing less than 3 amino groups, triaminotriazine, N-alkyl and -aryl substituted ureas or phenol and its alkyl derivatives and aldehydes, e.g. formaldehyde or acetaldehyde. Specified therapeutic, cosmetic and growth factor substances, which may be added prior to, during or after foaming up are antiseptics, tanning agents, e.g. tannin, zinc, uranium, lead, mercury, silver, bismuth and chlorides, sulphates and nitrates thereof, sulphur and sulphur compounds, boric, acetic and salicylic acid, aluminium acetate, oils and fats, phenols, sulphonamides, anaesthetics, vitamins, hormones, ferments, alkaloids, digitaloids, amino acids and auxins.  The aqueous solutions may also contain wetting agents, e.g. alkylated naphthalene sulphonic acids, alkali salts of high molecular weight fatty acids and quaternary ammonium compounds containing high molecular weight radicals and hardening catalysts, e.g. oxalic acid, sulphuric acid, phosphoric acid, lactic acid, ammonium chloride or alkali phosphates.  Gaseous foaming agents which are inert to the ingredients of the aqueous solution, e.g. air, oxygen, nitrogen, carbon dioxide and hydrogen sulphide are specified.  In the examples: an aqueous solution of a urea-formaldehyde resin containing sodium dibutyl naphthalene sulphonate and phosphoric acid is foamed whilst adding (1) aqueous sodium aluminium sulphate, (2) aqueous d-camphor; and (5) ionone during the foaming; (6) lithol fast red; and (7) ionone and ochre prior to foaming, the resultant foams being dried and granulated and in Example (7) mixed with rice starch.  In Examples (3) and (4), (3) methol and zinc oxide and (4) zinc oxide are added during the production of foamed up urea resins which are worked up as in Example (1).ALSO:A powder base for therapeutic and cosmetic preparations is made by drying and hardening a foam obtained from an aqueous solution of an aminoplast or phenoplast containing a therapeutic or cosmetic substance and grinding the hardened foam. Specified aminoplasts and phenoplasts are derived from urea, thiourea, buiret, aminotriazines containing less than 3 amino groups, triaminotriazine, N-alkyl and aryl substituted ureas or phenol and its alkyl derivatives and aldehydes, e.g. formaldehyde or acetaldehyde.  Specified therapeutic or cosmetic substances which may be added prior to, during, or after the foaming-up are antiseptics, tanning agents, e.g. tannin, zinc, uranium, lead, mercury, silver, bismuth and chlorides, sulphates and nitrates thereof, sulphur and sulphur compounds, boric, acetic and salicylic acid, aluminium acetate, oils and fats, phenols, sulphonamides, an sthetics, vitamins, hormones, ferments, alkaloids, digitaloids, amino acids and auxins.  The solutions may also contain wetting agents, e.g. alkylated naphthalene sulphonic acids, alkali salts of high molecular weight fatty acids and quaternary ammonium compounds containing high molecular weight alkyl radicals and hardening catalysts, e.g. oxalic acid, sulphuric acid, phosphoric acid, lactic acid, ammonium chloride or alkali phosphates.  Gaseous foaming agents which are inert towards the ingredients of the aqueous solutions, e.g. air, oxygen, nitrogen, carbon dioxide and hydrogen sulphide are specified.  In the examples, an aqueous solution of a ureaformaldehyde resin containing sodium dibutyl naphthalene sulphonate and phosphone acid is foamed whilst adding (1) aqueous sodium aluminium sulphate; (2) aqueous d-camphor, and (3) ionone, during the foaming; (6) lithol fast red, and (7) ionone and ochre prior to foaming, the resultant foams being dried and graduated and in Example (7) mixed with rice starch.  In Examples (3) and (4), (3) menthol and zinc oxide, and (4) zinc oxide are added during the production of foamed-up urea resins which are worked up as in Example (1).