Patent EP-1873667-A2 (EP)
Inventor: SALZSIEDER ECKHARD
IPC: G06F19/00
Filed: 2007-05-05
Abstract: Computerized determination of the characteristic daily profile of an individual glucose metabolism using the mathematical model, comprises: calculating the personal daily blood glucose concentration gradient (x(t)); calculating the personal 24-hour insulin activity profile (IE(t)), assimilation profile (BE(t)), anti-diabetic drug activity profile (OAD(t)) and sport activities profile (IDE(t)); measuring the blood glucose reference values (BG(t)); and synchronizing x(t), IE(t), BE(t), OAD(t), IDE(t) and BG(t) values. Computerized determination of the characteristic daily profile of an individual glucose metabolism using the mathematical model for describing the physiological glucose metabolism with the blood glucose concentration gradient, endogenous glucose balance, endogenous insulin metabolism and exercise-induced glucose metabolism, comprises: calculating the personal daily blood glucose concentration gradient (x(t)) of the individual from existing self-check information of the individual about his typically assimilated daily bread units, his medications with orally administered anti-diabetics of different classes of activity and insulin as well as his sport activities, in relation to the endogenous glucose balance variables and insulin metabolism as well as the exercise-induced glucose metabolism using a micro-computer system; extrapolating the values of (x(t)) that are calculated in a minute scale, on a 24-hours daily scale; calculating the personal 24-hour insulin activity profile (IE(t)), the personal 24-hour assimilation profile (BE(t)), the personal 24-hour anti-diabetic drug activity profile (OAD(t)) and the personal 24-hour sports activity profile (IDE(t)) for the individual; generating a reference daily blood glucose profile (BG(t)) that is specific for the individual, from the measured blood glucose values for the validity check of the (x(t)) that is calculated based on the model; producing the initial value for the numerical integration method, by calculating the daily average value of the reference daily blood glucose profile according to the mathematical equation given in the specification, where the calculated average value of the daily blood glucose concentration is equated to initial value for the numerical integration procedure for the calculation of the model-based calculation of the (x(t)); measuring and recording the blood glucose reference values of the individual preferably quasi-continuously in a 5-minute time frame over a period of up to 72 hours; extrapolating the (BG(t)) values with a large number of measuring points from the recorded single measurements, at equidistant intervals of 5 minutes on the 24-hour daily time scale by using a known statistical and averaging procedure; synchronizing x(t), IE(t), BE(t), OAD(t), IDE(t) and BG(t) values that are calculated on a model-based manner for an individual over the 24-hour daily time scale, using the appropriate data from the self-check data table and combining the values to form the daily profile that is characteristic to the individual with the quality of a metabolic fingerprint of his glucose metabolism and saving the values in an output file for further use; calculating the total insulin units administered per day with differential tag for the endogenous and exogenous portions by integration of the respective insulin activity surfaces; calculating the assimilated bread units per day by integrating the bread unit assimilating surface; calculating the number of anti-diabetic tablets per day by integration of the anti-diabetic drug-surfaces; calculating the overall activity of physical activities per day by integrating the sports activity surface; and simultaneously saving all these parameters in the output file. The daily personal characteristic profile of this individual is visualized in the form of the individual metabolic fingerprint of his glucose metabolism using well-known methods of graphical representation, where the six 24-hour profiles x(t), IE (t), B(t), OAD(t), IDE (t) and BG(t) of the personal characteristic daily profile of this individual that is saved in the output file is graphically represented on a single 24-day time scale according to their specific quantitative and qualitative characteristics. An independent claim is included for a mechanism for the computerized determination of the characteristic daily profile (CTP) of the individual glucose metabolism in the form of a metabolic fingerprint.