baber/WOPTO huggingface dataset:
Patent CA-2101065-A1 (CA)
Title: Vaccination and methods against diseases resulting from pathogenic responses by specific t cell populations
Inventor: HOWELL MARK D
IPC: C07K16/00
Filed: 1992-01-21
Abstract: The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulatedreplication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. Such a peptide can bind to conventional antigens complexed to MHC antigen presenting cells or to superantigens. Means of determining appropriate amino acid sequences for such vaccines are also provided. The vaccine is administered to the vertebrate in a manner that induces an immune response directed against the TCR of T cells mediating the pathology. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. The invention aditionally provides specific .beta.-chain variable regions of T cell receptors, designated V.beta.3, V.beta.4, V.beta.12, V.beta.14 and V.beta.17, which are associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and multiple sclerosis (MS). Also provided are means to detect, prevent and treat RA and MS. Methods of administering DNA or RNA encoding the polypeptides useful as vaccines of the present invention into the tissue cells of an individual is also provided.
Patent CA-2101162-A1 (CA)
Title: Dna encoding a human 5-ht1e receptor and uses thereof
Inventor: WEINSHANK RICHARD L
IPC: C12P21/08
Filed: 1992-12-02
Abstract: This invention provides an isolated nucleic acid molecule encoding a human 5-HT1E receptor, an isolated protein which is a human 5-HT1E receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1E receptor, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1E  receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1E receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT1E receptor, pharmaceutical compounds related to human 5-HT1E receptors, and nonhuman transgenic animals which express DNA encoding a normal or a mutant human 5-HT1E receptor.  This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT1E receptor.
Patent CA-2102060-A1 (CA)
Title: Liquid dispensing apparatus
Inventor: SHUB MICHAEL
IPC: B67C3/24
Filed: 1993-10-29
Abstract: ABSTRACT OF THE DISCLOSURE         In general, distilled water dispensers used in commercial establishments such as drug and convenience stores are unimaginative, coin operated and often messy devices.  A relatively simple substitute for such dispensers includes a large housing similar in size and shape to a soft drink dispenser, a smaller housing in the large housing with essentially only the door of the inner housing extending out of the center of the larger housing.  A one, three or five gallon bottle is placed in the inner housing and the door is closed.  These two actions close two switches which cause a dispensing head to descend from a rest position into the open mouth of the bottle.  Movement of the dispensing head to the dispensing position closes a third switch, which causes a solenoid valve to open permitting the flow of distilled water to the bottle.  When the bottle is full, the rising water in the bottle closes a circuit including two wire probes extending downwardly into the bottle from the dispensing head to close the solenoid valve and to return the dispensing head to the rest position.
Patent CA-2103141-A1 (CA)
Title: Soap compositions of carboxylic acids and amines useful in removal and prevention of scale
Inventor: HIEATT ALAN C
IPC: B08B9/02
Filed: 1992-05-11
Abstract: A soap composition for the removal and prevention of scale in aqueous media comprising a 1:1 stoichiometric equivalent of an organic carboxylic acid and an amine base. The organic carboxylic acid is selected from the group consisting of hydroxy-acetic, citric, acetic, gluconic, salicylic, tartaric and benzoic, and mixtures thereof. The amine base is selected from the group consisting of monoisopropanolamine, diisopropanolamine, triisopropanolamine, monoethanolamine, diethanolamine, triethanolamine, diethylamine, and mixtures thereof.
Patent CA-2103919-A1 (CA)
Title: Herbicides for citrus, sugarcane, oil palm and the like
Inventor: AMUTI KOFI S
IPC: A01N43/90
Filed: 1992-01-29
Abstract: The invention is directed to use of herbicides of Formula (I), and its agriculturally suitable salts, wherein R is isopropyl, allyl, propargyl or -CH(CH3)C=CH; X is Cl or Br; Y is F or Cl; Z is H or can be taken together with R as (a) such that the linking oxygen is attached to the methine carbon. Herbicides that comprise compounds of formula (I) provide broad spectrum weed control in citrus, sugarcane, coffee, banana, oil palm, loblolly pine, rubber, cocoa, grapes, plantain, pineapple, fruit trees such as apple trees, nut trees, and turf grass such as Kentucky bluegrass and the like.
Patent CA-2105727-A1 (CA)
Title: Titration of microbial contamination
Inventor: SYRINEK ALLEN R
IPC: C12Q1/08
Filed: 1993-09-08
Abstract: ABSTRACT         The invention relates to a method of determining the degree of microbial contamination in a liquid substance, comprising the following steps:  (a) selecting a number of titration wells for holding progressive serial dilutions of a starting sample of the substance; (b) adding to each well a first solution of an equal amount of microorganism nutrient along with an equal amount of a redox indicator which changes from one color to another in the presence of active microbial respiration;          (c) establishing in a starting or first well an index solution comprising a measured amount of the substance in said first solution in the starting well; (d) diluting the subsequent wells in a serial dilution starting with an aliquot of the index solution; and (e) recording the number of serial wells which exhibit the color changes as a proportional indication of the degree of contamination.  The method provides detection of microbial contamination by an accelerated process so that an unacceptable contamination may be easily and quickly determined.
Patent CA-2108689-A1 (CA)
Title: Compositions and methods for inhibiting elastase
Inventor: MILLER EDWARD J
IPC: A61K38/17
Filed: 1992-04-17
Abstract: This invention provides a compound comprising: (1) a polypeptide moiety having a) an identifying number of amino acids for SPAAT, b) an elastase binding activity; and (2) an extracellular matrix protein bound to the polypeptide moiety. Also provided is a method of inhibiting an elastase comprising contacting the elastase with a polypeptide moiety having: (1) an identifying number of amino acids for SPAAT; (2) a collagen binding activity; and (3) elastase binding activity.
Patent CA-2110413-A1 (CA)
Title: Self-Thickened Cleaning Compositions
Inventor: SCIALLA STAFANO
IPC: C11D3/37
Filed: 1992-06-08
Abstract: Self-thickened aqueous cleaning compositions are described which comprise an alkyl sulfate anionic surfactant and an electrolyte system. The compositions are made physically stable, even at low temperature, by incorporating therein a nonionic surfactant from a selected class. The figure compares a composition of the present invention containing UKANIL R, an ethoxylated alcohol the same composition not containing UKANIL R.  The present invention shows viscosity stability over a broad temperature range.
Patent CA-2116002-A1 (CA)
Title: Molding machine
Inventor: DEL MONTE ERNEST J
IPC: B28B7/08
Filed: 1992-08-07
Abstract: A molding machine (10) for casting a modular mass-produced concrete product.  The molding machine includes a station-ary support system (12) and a rotatable apparatus (11) having a horizontal axis of rotation (13). Rotational means (24) rotate the rotatable apparatus (11) from an upward facing casting position, and for rotating said rotatable apparatus (11) 180 degrees to a downward facing load and unload position, a transporter (138) is attachable to said rotatable apparatus (11) "and hoisting means 110 fixed to the rotatable apparatus (11) and coupled to the transporter (138) for raising or lowering the transporter (138) from said rotatable apparatus" (11).
Patent CA-2117256-A1 (CA)
Inventor: PENZIAS ARNO A
IPC: H04M3/56
Filed: 1994-04-06
Abstract: A method and apparatus for tracking participation in a conference call is disclosed. A conference tracker at a first location transmits a status signal to another conference tracker at a second location. The conference tracker at the second location receives the status signal and recognizes it as representative of an attribute of one or more of the parties at the first location. The attribute represented may be the identity of the first location, thereby informing the conference tracker at the second location that the first location remains connected to the conference call. In this manner, the conference tracker may inform a party of the number of connected locations or that a particular location has disconnected. The attribute represented may be the listening party of the location of the speaking party. The attribute represented may be the identity of the speaking party, thereby enabling the conference tracker at the second location to determine which party is speaking. Status signals transmitted by each conference tracker may comprise audio pulses of unique frequencies, thereby enabling each conference tracker to determine the origin of each status signal. Consecutive pulses may be used to identify a particular status (e.g., connected or speaking).
Patent CA-2117866-A1 (CA)
Title: Fluid urea-containing fertilizer
Inventor: WESTON CHARLES W
IPC: C05G5/23
Filed: 1994-10-11
Abstract: An improved fluid urea-containing fertilizer composition is disclosed; the composition is essentially comprised of an aqueous solution of urea, ammonium nitrate, N-(n-butyl)thiophosphoric triamide (NBPT), dicyandiamide (DCD), and may optionally also contain a clay as a suspending agent. The fluid fertilizer composition can be applied to a field crop in a single application and will nevertheless supply sufficient nitrogen to the plants throughout their growth and maturing cycles. As a result, the improved composition increases the nitrogen uptake efficiency of plants, enhances crop yields, and minimizes the loss of nitrogen from the soil. The NBPT is incorporated into the fluid fertilizer composition by blending a concentrated solution of N-(n-butyl)thiophosphoric triamide in a solvent selected from the group consisting of liquid amides such as an N-alkyl pyrrolidone directly with an aqueous solution of urea and ammonium nitrate, optionally also containing a suspending agent and commonly referred to in the fertilizer trade as UAN; the DCD may be added to the UAN fluid as a solid, a suspension, or in dissolved form along with the NBPT.
Patent CA-2120336-A1 (CA)
Title: Detecting digeorge syndrome mutations
Inventor: EMANUEL BEVERLY S
IPC: C12Q1/68
Filed: 1992-09-02
Abstract: There is provided by this invention methods of detecting genetic deletions and mutations associated with at least one condition selected from the group consisting of DiGeorge syndrome, Velocardiofacial syndrome, CHARGE association, conotruncal cardiac defect, and cleft palate in a human patient comprising the steps of providing a DNA containing test sample from said human patient; identifying whether there are less than two functional copies of the DiGeorge syndrome critical region loci, whereby said identification of less than two copies of the DiGeorge syndrome critical region loci is indicative of a likelihood that said person has at least one of DiGeorge syndrome, Velocardiofacial syndrome, CHARGE association, conotruncal cardiac defect, and cleft palate. Probes and primers useful in the invention are also provided as are diagnostic kits.
Patent CA-2121596-A1 (CA)
Title: Novel thiosemicarbazonethiones
Inventor: MISSBACH MARTIN
IPC: C07D417/12
Filed: 1993-09-25
Abstract: The invention relates to novel thiosemicarbazonethiones of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl or also lower alk-2-yn-1-yl, R2 and R3 are each independently of the other hydrogen or lower alkyl or, taken together, are lower alkylidene, R4 is hydrogen, lower alkyl, lower alkoxy, aryl or aryl-lower alkyl, R5 is lower alkyl, aryl, aryl-lower alkyl, unsaturated or saturated heterocyclyl-lower alkyl, or is also lower alkyloxycarbonyl-lower alkyl, and the salts thereof, to a process for the preparation of these compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.
Patent CA-2121674-A1 (CA)
Title: Biocompatible implant for the timing of ovulation in mares
Inventor: TRIGG TIMOTHY E
IPC: A61K38/09
Filed: 1992-10-19
Abstract: The induction of ovulation in mares having a maturing ovarian follicle is controlled by implanting into the mare a solid bi-ocompatible implant comprising a solid carrier and an effective amount of leutinising hormone releasing hormone (LHRH) or an agonist of LHRH such as Deslorelin. The solid carrier is preferably a biologically absorbable inorganic salt mixed with an organ-ic tablet release compound.
Patent CA-2123725-A1 (CA)
Inventor: SHUKNECHT LEE N
IPC: A01D31/00
Filed: 1994-05-17
Abstract: A machine for harvesting onions utilizes a blower which provides a stream of air through a duct, having an opening across which the onions pass and are topped.  The blower has a bladed fan in a cylindrical housing open at both ends.  The fan blades are supported by arms which, with the blades, define a support truss for each blade in the form of a triangular structure, having arms meeting at an apex connected approximately midway of the end of the cylindrical housing and a base provided by the blade to which the arms are connected.  A rigid support is provided together with an enlarged and substantially unobstructed intake passageway for air along the axis of rotation of the fan which is pressurized and forced through the duct, using less horsepower and fuel than conventional fans of like size and air flow.  The air flow is controllable in air pressure by a shear plate which is moveable into and out of the cylindrical housing and the air direction is adjustable by a vane provided by a sidewall of the duct adjacent to the outlet and may also be controlled in direction by vanes in a hood over the duct outlet.
Patent CA-2124083-A1 (CA)
Title: Preparation of substituted piperidines
Inventor: GODEK DENNIS M
IPC: C07D213/75
Filed: 1992-11-24
Abstract: Novel processes are disclosed for the preparation and resolution of substituted piperidines of formula (I) wherein R1 and R2 are defined as below; and related compounds, as well as novel intermediates used in such processes.
Patent CA-2127812-A1 (CA)
Inventor: YOKOUCHI KISHIO
IPC: F25B9/14
Filed: 1989-11-15
Abstract: A cryogenic device having a closed cycle system, comprising a closed cryostat containing, as a cooling medium, at least one liquid fluorocarbon of the formula:  CmF2m+2,  wherein m is an integer of 1 to 4; an article to be cooled being immersed in the cooling medium; and a heat exchanger pipe which is disposed in an upper inner portion of the cyrostat and communicates with a separate liquefier so that the cooling medium being boiled and vaporized as a result of a heat generation in the cryostat is liquefied within the same cryostat as a result of a heat exchange between a vapor of the cooling medium and a liquid gas circulated as a heat exchange medium in the heat exchanger pipe, wherein the heat exchange medium is liquid nitrogen.
Patent CA-2129232-A1 (CA)
Title: Erasable optical media
Inventor: PARKINSON DEAN B
IPC: G11B7/24
Filed: 1994-02-18
Abstract: Abstract of the Invention The invention relates to a novel information recording medium and the recording of information thereon.  The recording medium material possesses both retention and expansion characteristics suitable for use with optical recording,reading and erasing systems.
Patent CA-2131816-A1 (CA)
Title: Technetium-99m labeled peptides for imaging inflammation
Inventor: BUTTRAM SCOTT
IPC: A61K51/00
Filed: 1993-03-12
Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, ,the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.
Patent CA-2133197-A1 (CA)
Title: Mounting and tensioning arrangements for screens
Inventor: BJOERKLUND OLA
IPC: B07B1/48
Filed: 1993-04-19
Abstract: In a vibratory screening apparatus, a withdrawable lower fine mesh screen assembly (17) has a screen unit (19) releasably mounted on a grid/frame structure (20). The screen unit (19) has a sheet (21) of mesh material bonded to a grid or lattice (22) of a yieldable material such as a hard rubber, and this lattice (22) and the edges of the mesh (21) are also fixed to relatively rigid side members (23) which are mutually free each from the others. In the structure (20), a rigid grid of support bars (26) supports the lattice (22) with a sliding contact interface, and a frame (28) incorporates pneumatically actuated tensioners (30) and clamps (34A, 34B) respectively for tensioning/locking the screen unit (19) and coupling the screen assembly to the vibratory structure. The tension in the screen unit (19) is adjustable whilst on the structure (20) by virtue of the yieldability of the lattice (22) and its sliding contact interface with the support bars (26). Away from the screen assembly, the screen unit (19) is relaxed and less vul-nerable to damage or deterioration of tensioning quality.
Patent CA-2133830-A1 (CA)
Inventor: HIGASHI ROBERT E
IPC: B01L3/00
Filed: 1992-06-11
Abstract: A thermoelectric sensor element (45,46,47) that is adapted to respond to thermal radiation is capable of manufacture into a sensor array on a single crystal semiconductor (10), such as silicon. An anisotropically etched pit (16) is provided under the sensing surface, and the pit (16) generally corresponds to the geometry of the sensor element. The geometry is selected to be rectangular and falls along a selected orientation of the particular crystalline structure used for manufacture of the device to thereby allow for a high density of the sensor elements. The sensor elements arc manufactured of two dissimilar metals (45,46) in a sinuous pattern to provide the thermoelectric effect.
Patent CA-2134657-A1 (CA)
Title: Methods of treating obesity with purine related compounds
Inventor: LANOUE KATHRYN F
IPC: A23K1/16
Filed: 1993-05-06
Abstract: There is disclosed a method of treating obesity in warm-blooded animals, including humans, as well as a method of increasing the muscle mass to fat ratio in farm animals. The methods entail administering to an animal in need thereof, an effective amount of certain 8-phenylxanthines substituted in the 3- or 4-position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acetic grouping.
Patent CA-2136250-A1 (CA)
Title: Film Transporting Apparatus and Film Processing System Using the Same
Inventor: HASHIZUME KEIJI
IPC: G03B27/62
Filed: 1994-11-21
Abstract: A film transporting apparatus for a film processing system. The apparatus includes a pair of frame members pivotably connected to each other to be opened and closed, a transport mechanism provided to each of the frame members and operable to transport a film along a predetermined film transport passage when the frame members are closed, an optical sensor for detecting film information including a light emitting portion provided in one of the frame members and a light receiving portion provided in the other frame member, positioning engaging portions provided respectively to the frame members and coming into engagement with each other in association with a pivotal movement of the frame members to a closed state. The apparatus further includes a movable frame member movably provided to one of the frame members. This movable frame member supports the positioning engaging portions and the light emitting portion or the light receiving portion and allows relative movement between the positioning engaging portions provided respectively to the pair of frame members.
Patent CA-2137286-A1 (CA)
Title: Process of making low calorie nut products
Inventor: ZOOK DENIS
IPC: A23L25/00
Filed: 1993-06-02
Abstract: The present invention relates to nuts and nut products which have at least a portion of their natural fat replaced with a low calorie fat-like material. This is achieved by partially defatting the nuts and then either contacting them or combining (i.e., mix-ing) them with a non-disgestible or partially digestible triglyceride material which includes a triglyceride bearing one long chain fatty acid residue and two short chain fatty acid residues. The resulting nuts and nut products have the organoleptic character of full fat nuts and nut products but a much lower calorie content.
Patent CA-2144502-A1 (CA)
Title: Slide-on car cover
Inventor: SCHWEITZER DONNA
IPC: B60J11/00
Filed: 1995-07-26
Abstract: This invention is an improvement on the present car covers.  Present car covers are difficult for one individual to put on or take off the car because there is nothing to control the mass of material involved in a car cover. This invention consists of a sleeve sewn down the middle (lengthwise) of the underside of the car cover, through which a cord is inserted into this sleeve. This cord has a plastic hook attached at each end.  One hook clamps unto the rear bumper and the cord is then drawn over the top of the car where the other hook is clamped to the front bumper. The car cover slides easily back and forth on this cord.  The front end of the cord has an adjustable band where it is attached to the front hook for adjusting the front cord length to accommodate vehicle length.
Patent CA-2146760-A1 (CA)
Title: Rotor blade balance weight assembly
Inventor: REINFELDER WILLIAM C
IPC: B64C27/00
Filed: 1993-11-24
Abstract: A rotor blade balance weight assembly comprises a weight retention housing (10) having a hollow core (22) and being closed on one end (12). The housing is disposed in an aperture which extends from the upper (52) to the lower (53) airfoil surfaces of the rotor blade (50). The closure end of the housing is contoured to match the airfoil upper surface contour. A stud (70) extends along the central axis of the housing, and washer-like balance weights (72) are received over the stud and secured by a locking nut (75). The open end of the housing is closed by a cover plate (25) that is contoured to match the airfoil lower surface contour, the cover plate being secured to the housing by a nut (78) in locking engagement with the stud. A pair of clips (37) are received within the housing, each clip having a tab suface (40) which extends through slots (42) in the housing, the clips being secured by the locking nut and stud. The cover plate and housing closed end are counter sunk (17, 59, 27) to provide a smooth airfoil surface.