Patent SG-11201809211Q-A (SG)
Title: Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans
Inventor: Lowery Ryan
IPC: A61K31/23
Filed: 2017-04-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111011101 HOE HO 11111 0 I 3E110 HE ME 110 11110 1111 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/184788 Al 26 October 2017 (26.10.2017) WIPO I PCT — (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) Inventors: LOWERY, Ryan; 3517 Harken Circle, Tam- International Patent Classification: (74) Agent: DAHM, Elizabeth, Philip; Ferguson Braswell A61K 31/23 (2006.01) A61K 31/198 (2006.01) Fraser Kubasta PC, 2500 Dallas Parkway, Suite 600, Plano, A61K 31/19 (2006.01) TX 75093 (US). International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/028465 kind of national protection available): AE, AG, AL, AM, International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 19 April 2017 (19.04.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/324,798 19 April 2016 (19.04.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 15/491,924 19 April 2017 (19.04.2017) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Applicant: KETO PATENT GROUP, INC. [US/US]; (84) Designated States (unless otherwise indicated, for every 901 Sam Rayburn Highway, Melissa, TX 75454 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, pa, FL 33607 (US). WILSON, Jacob; 110 S Matanzas TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Ave., Tampa, FL 33609 (US). WELLS, Shawn; 2504 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Lincolnshire Lane, Lewisville, TX 75056 (US). UNDER- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, WOOD, Brian; 901 Sam Rayburn Highway, Melissa, TX TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 75454 (US). HARDING, Christopher, N.; 2155 S. Ocean KM, ML, MR, NE, SN, TD, TG). Blvd #16, Delray Beach, FL (US). LACORE, Terry; 901 Sam Rayburn Highway, Melissa, TX 75454 (US). = = _ = 7r administered , 1 medium Title: ADMINISTRATION OF Figure 11 1.6- Q 1.4- <7 E 1.2- E 4 ft ••••••• n .an a) g 0.8- z 0.6- Iv 0.4- o 4 0.2- al 0.0 BUTYRATE, BETA-HYDROXYBUTYRATE, AND RELATED COMPOUNDS IN HUMANS -0- R-BHB 5g -a- DL 5g • • • • • . . = (54) = = = _ = = = = — = 1-1 .4 ot ot N (57) X 1-1 ) reduce ---- or IN 0 ine ei inflammatory (e.g., 0 30 60 90 120 Time (min) : In various implementations, beta-hydroxybutyrate, related compounds, and/or one or more other compounds may be to an individual to cause weight loss, weight maintenance, elevate blood ketone levels, maintain blood ketone levels, blood glucose levels, maintain blood glucose levels, improve energy, focus, mood, cognitive function, or aide with neurological disorders and/or combinations thereof. Other compounds may include short chain fatty acids, short chain triglycerides, chain fatty acids, medium chain triglycerides, long chain fatty acids, long chain triglycerides, berberine, metabolites of berber- dihydroberberine), and/or combinations thereof. C [Continued on next page] WO 2017/184788 Al MIDEDIMOMMIDIRMEMOMOHOHOMMODEVOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply patent (Rule 4.17(H)) for and be granted a Published: — with international search report (Art. 21(3))