baber/WOPTO huggingface dataset:
Patent EP-4313099-A2 (EP)
Title: Her2/4-1bb bispecific fusion proteins for the treatment of cancer
Inventor: ZETTL MARKUS
IPC: A61K38/00
Filed: 2022-03-23
Abstract: The disclosure provides methods and compositions for treating tumors, particularly HER2-expressing tumors. The method comprises administering a therapeutically effective amount of a HER2/4-1BB bispecific fusion protein. The HER2/4-1BB bispecific fusion protein may be administered at a first dose and, subsequently, at a second dose, wherein the first dose exceeds the second dose.
Patent EP-4285823-A2 (EP)
Inventor: MARTINEZ AINARA GARDE
IPC: A61B5/361
Filed: 2023-05-23
Abstract: Embodiments are directed to systems and methods for determining a cardiac burden of a user. Methods include collecting a series of cardiac measurements at a first set of time points using one or more sensors and determining a set of measured data points. Each measured data point can include a time value from the first set of time points and a classification comprising one of an occurrence of a qualified cardiac event or absence of the qualified cardiac event. Methods include generating a set of additional data points each including a time value from the second set of time points and a classification of one of the occurrence of the qualified cardiac event or the absence of the qualified cardiac event. Methods include determining a value of the cardiac burden for a predefined period of time using the set of measured data points and the set of additional data points.
Patent EP-4246098-A2 (EP)
Title: All digital travel time flow meter using time reversed acoustics
Inventor: HELFENSTEIN MARKUS
IPC: G01F1/66
Filed: 2021-03-31
Abstract: A microcontroller and a method for determining a flow velocity with an electronic processing unit of an ultrasonic travel time flow meter with arbitrary waveform signals. The electronic processing unit comprises receiver and transmitter terminals, a signal processing unit and a signal generating unit that is configured to generate an oscillating electric output signal with a time dependent amplitude, wherein the time-dependent amplitude varies according to stored signal parameters.
Patent EP-4289813-A2 (EP)
Inventor: METCALF BRIAN
IPC: C07C65/21
Filed: 2012-12-28
Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Patent EP-4283882-A2 (EP)
Title: Methods and apparatuses for codebook restriction for type-ii feedback reporting and higher layer configuration and reporting for linear combination codebook in a wireless communications network
Inventor: VENKATESH RAMIREDDY
IPC: H04B7/0456
Filed: 2019-12-16
Abstract: The embodiments herein relate to a method performed by a UE (900) for providing a channel state information (CSI) feedback in a wireless communication system including at least the UE and a gNB (800) or a radio network node. The UE (900) is operative, by means of e.g. the processor (910) to: estimate the MIMO channel between the gNB (800) and the UE (910) based on received DL reference signals for the configured resource blocks. The UE (900) is further operative to calculate, based on a performance metric, a precoder matrix, for a number of antenna ports of the gNB (800) and configured subbands, the precoder matrix being based on two codebooks and a set of combination coefficients for complex scaling/combining one or more of vectors selected from a first codebook and a second codebook, and the UE (900) is operative to report a CSI feedback and/or a PMI and/or a PMI/RI, to the gNB (800), used to indicate the precoder matrix for the configured antenna ports and resource blocks.
Patent EP-0025888-A2 (EP)
Inventor: PAGILAGAN ROLANDO UMALI
IPC: C08L101/00
Filed: 1980-08-27
Abstract: A polymeric composition having improved zinc chloride resistance comprising nylon 612, plasticizer and an olefin polymer having sites which adhere to the nylon 612 resin.
Patent EP-0030841-A2 (EP)
Inventor: NAHAS NICHOLAS CHARLES
IPC: C10J3/00
Filed: 1980-12-10
Abstract: Carbonaceous solids slurried in an aqueous solution (12), which preferably contains catalyst constituents having gasification activity, e.g. alkali metal carbonates are dried by contacting the slurry with superheated steam in a fluid bed slurry dryer (26) and the resultant dried solids are subsequently gasified with steam generated in the drier.
Patent EP-0033839-A2 (EP)
Inventor: KNECHT HEINZ
IPC: F16F9/50
Filed: 1981-01-09
Abstract: Ein derartiges Teleskop-Feder-Dämpferelement, insbesondere für Kraftfahrzeuge, mit in einem ölgefüllten Arbeitsraum (2) verschiebbarem Arbeitskolben (3) mit Dämpfungseinrichtungen und einer hohlen Kolbenstange (4) weist einen mit dem Arbeitsraum (2) in offener Verbindung stehenden Gasfederraum (6, 6'), einen Ölvorratsraum (10) und eine an einer Zwischenwand (11) elastisch gelagerte hohle Pumpenstange (13) auf, die an ihrem einen Ende mit dem Ölvorratsraum (10) unterhalb von dessen Ölspiegel in Verbindung steht und an ihrem anderen, mit einem Pumpen-Saugventil (14) versehenen Ende mit einem in der hohlen Kolbenstange (4) angeordneten Pumpenraum (15) zur Niveauregelung zusammenwirkt. Der Gasfederraum (6, 6') enthält einen an seinem Umfang abgedichtet geführten Trennkolben (8, 8'), ist im Bereich der die Pumpenstange (13) abstützenden Zwischenwand (11) axial an den Arbeitsraum (2) angeschlossen und mit diesem über wenigstens eine in der Zwischenwand (11) befindliche Durchtrittsöffnung (12) verbunden, wobei die Zwischenwand (11) selbst im Bereich des Arbeitsraums (2) elastisch ausgebildet ist und ein Pumpen-Ansaugrohr (13a) zur Verbindung des Pumpenstangen-Hohlraums (20) mit dem Ölvorratsraum (10) unterhalb des Ölspiegels trägt, welches gegenüber den Bewegungen der Zwischenwand (11) nachgiebig ausgebildet ist, und der Trennkolben (8, 8') weist an seiner der Zwischenwand (11) zugekehrten Stirnseite eine Ausnehmung (21, 21') auf, in welcher bei Anordnung des Trennkolbens (8, 8') im Bereich der Zwischenwand (11) das Pumpen-Ansaugrohr (13a) aufnehmbar ist.
Patent EP-0034279-A2 (EP)
Inventor: KAMPFER HELMUT DR
IPC: C07D403/12
Filed: 1981-01-28
Abstract: 1. Hydroxy alkane sulphonic acid (dulphoalkyl) ester of the formula see diagramm : EP0034279,P11,F1  wherein X denotes H**+ or a cation, n denotes 3 or 4, and the radicals R in each  see diagramm : EP0034279,P11,F2  group independently of one another denote H or alkyl with up to 4 C atoms.
Patent EP-0033982-A2 (EP)
Inventor: MUIS ROELOF
IPC: B41F17/16
Filed: 1981-01-06
Abstract: The raised edge part 3 of a deep-drawn plastics cover is printed by pressing a carrier 13 of a resilient deformable material, carrying a colouring composition, against said edge part 3.An apparatus for performing the method comprises a deformable carrier 13 or 8a, 8b, for carriyng a colouring composition. The carrier 8a, 8b is integral with a cylindrical part 7 being connected with a first cylinder 6 and two concentric cylinders 9 and 10, positioned around said first cylinder at either side thereof, deform annular parts 8a, 8b of resilient material and press the annular parts 8a, 8b against the edge part 3, when on the one hand first cylinder 6 and on the other hand the two concentric cylinders 9 and 10, are moved with respect to each other.The colouring composition may also be carried by a layershaped carrier material 13.
Patent EP-0038673-A2 (EP)
Inventor: DAVIS ROBERT BRUCE
IPC: F17D1/08
Filed: 1981-04-15
Abstract: There is disclosed an apparatus capable of delivering small controlled quantities of a liquid cryogen to a use point in an intermittent manner comprising an on-period during which a predetermined amount of liquid cryogen is delivered to said use point continuously during said on-period, followed by an off-period during which no liquid cryogen is desired at said use point, said apparatus being characterised by comprising in combination:
     (a) insulated conduit means for transferring cryogen from a liquid cryogen supply source to said use point;   (b) subcooling means adjacent said use point and upstream thereof, adapted to condense vaporized cryogen in said conduit means and to subcool said cryogen; and   (c) flow control means located downstream of said subcooling means, adapted to cause a flow (low flow) of cryogen downstream of said subcooling means during said off-period sufficient upon vaporization to offset heat leaks in, as well as purge cryogen vapor from, said conduit means downstream of said subcooler, said flow control means also being adapted to cause a higher flow of said cryogen during said on-period so that said predetermined amount of liquid cryogen is delivered to said use point essentially free of vapor.   
     There is also disclosed a process for delivering small controlled quantities of liquid cryogen to a use point in an intermittent manner comprising an off-period during which no liquid cryogen is desired at said use point followed by an on-period during which a predetermined amount of said liquid cryogen is delivered to said use point continuously for the duration of said on-period, said method being characterised by comprising:
     (a) transferring said cryogen through a conduit from a liquid cryogen supply source to said use point;   (b) in the course of said transfer and adjacent said use point, cooling said cryogen so as to condense all vapor formed therein and to further subcool said liquid to a temperature at which the vapor pressure of said liquid is higher than its equilibrium vapor pressure at said temperature; and   (c) controlling the flow of said cryogen in said conduit downstream of the point at which said subcooling takes place by (i) adjusting said flow to a low value during said off-period sufficient to completely absorb the heat added through heat leak downstream of said cooling point, thereby vaporizing said cryogen so that essentially no liquid cryogen reaches said use point and compensating for said heat leak, and (ii) adjusting said flow to a higher value during said on-period so that said predetermined amount of said cryogen is delivered to said use point essentially free of vapor.
Patent EP-0047639-A2 (EP)
Inventor: HARRISON JOHN D
IPC: C22C19/03
Filed: 1981-09-04
Abstract: The invention relates to shape memory alloys consisting essentially of nickel, titanium, and copper. The alloys of this invention, which contain less than a stoichiometric amount of titanium, are capable of possessing shape memory with a temperature of mid-recovery greater than -196°C. The presence of from 1.5 to 9 atomic percent copper stabilizes the alloys to tempering, and also improves their workability and machinability. Alloys according to this invention are useful in pipe couplings, electrical connectors, actuators, and similar applications involving shape memory.
Patent EP-0054416-A2 (EP)
Inventor: CHAKRABARTI JIBAN KUMAR
IPC: A61K31/00
Filed: 1981-12-10
Abstract: These are described compounds of formula (I)
     or an acid addition salt thereof; in which R 1 , R 2 , R 3  and R 4  independently represent hydrogen, C 1-4  alkyl, C 2-4  alkenyl, halogen, C 1-4  haloalkyl, nitro, C 1-4  alkoxy, C 1-4  haloalkoxy, C 1-4  alkylthio or phenylsulphonyl; in which R 5  is a group of the formula
     where R 7  is hydrogen or C 1-6  alkyl, R 8  is hydrogen or C 1-4  alkyl and n is 0 or 1, provided that when R 7  is hydrogen n is 0; and in which R 6  is attached to the 1, 2 or 3 position of the triazole ring and is hydrogen, C 1-10  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl C 1-4  alkyl, phenyl, benzyl or acyl. These compounds are pharmaceutically active and are especially useful in the treatment of disorders of the central nervous system. They are prepared by reacting an amine of formula R S H with a triazolobenzodiazepine intermediate appropriately substituted at the 10-position or by ring-closing the appropriate anilinotriazole.
Patent EP-0052585-A2 (EP)
Inventor: HELLSTROM INGVAR
IPC: B23B27/16
Filed: 1981-10-22
Abstract: This invention relates to a cutting tool comprising a cutting insert holder with a cutting insert positioned in a cutting insert receiving site and provided with a hole. The . cutting insert is clamped by a locking screw positioned in the cutting insert hole and threaded into the cutting insert holder. The end part of the locking screw, which end part is positioned in the cutting insert hole, is excentrical relative to the rest of the screw and has a cross section deviating from that of the cutting insert hole. When clamping the cutting insert there is only a point contact between the screw and the cutting insert hole.
Patent EP-0066753-A2 (EP)
Inventor: GEHLHAUS JURGEN DR
IPC: C07D317/30
Filed: 1982-05-21
Abstract: Die stereospezifische Herstellung von D-( + )-Biotin wird dadurch verbessert, daß 3,4-Isopropyliden-D-arabinose, deren OH-Gruppe in 2-Stellung nicht geschützt ist, mit Alkoxycarbonylprop-1-en-3-yliden-triphenylphosphoran zu 6,9-Dihydroxy-7,8-isopropylidendioxy-nona-2,4-diensäureester umgesetzt wird, der katalytisch hydriert und dann in an sich bekannter Weise zu D-( + )-Biotin umgesetzt wird.
Patent EP-0083108-A2 (EP)
Inventor: OHASHI HIROYUKI
IPC: A61K31/12
Filed: 1982-12-28
Abstract: An aqueous solution containing ubidecarenone which is characterized by the fact that a hydrogenated lecithin is incorporated. This solution is stable and free from side effects.
Patent EP-0065389-A2 (EP)
Inventor: YAMADA JUN
IPC: H03H3/08
Filed: 1982-05-06
Abstract: A surface acoustic wave device comprises on a piezoelectric substrate an interdigital transducer having an interdigital sending electrode part (1') in the formed direction and an interdigital reflecting electrode part (2') in the reverse direction. An electrical phase difference of 0 (radian) is applied between the sending and reflecting electrode parts while a distance (6') between the sending and reflecting electrode parts providing a geometrical phase difference therebetween is established to bewhere n is a positive integer and λ<sub>0</sub> is the wavelength of surface acoustic wave.
Patent EP-0072154-A2 (EP)
Inventor: RICHARDSON ROBERT
IPC: H03K5/04
Filed: 1982-07-29
Abstract: A pulse circuit uses a transformer to convert a hiigh current pulse at relatively low voltage into a very high cottage pulse which is able to directly drive a magnetron oscillator. The circuit forms part of a radar transmitter in which the transmitted pulse lengths are to be varied. It is not satisfactory to alter the structure of the transformer or that of a pulse formingnet- work which is used to feed the transformer when variation in the pulse length is required. The invention provides a bias circuit which magnetically biasses the core material of the transformer, so that when a pulse is subsequently applied to the transformer the flux of the core material saturates after a predetermined interval of time which is dependent on the bias level. In this way accurate control of pulse length can be achieved and the characteristics of the pulse forming network and the transformer are used to determine the rising and falling edges of microwave pulses generated by the magnetron.
Patent EP-0111618-A2 (EP)
Inventor: FETZER GUENTER
IPC: G06K7/12
Filed: 1983-02-18
Abstract: Bei einem optischen Markenerkennungsgerät weist der Lichtsender zwei wahlweise einschaltbare Lichtquellen (11, 12) auf, welche Lichtbündel unterschiedlicher Spektralzusammensetzung aussenden. Ein halbdurchlässiger Spiegel (15) lenkt die Lichtbündel (13, 14) beider Lichtquellen (11, 12) auf einen gemeinsamen optischen Weg (16).
Patent EP-0105092-A2 (EP)
Inventor: MIHARA HISASHI
IPC: C12N9/64
Filed: 1983-06-28
Abstract: The invention discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification procedures into the individual active ingredients including six novel proteases named F-OHM-45, F-I-1-HM-54, F-1-2-HM-15, F-II-HM-64, F-III-1-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases.
Patent EP-0099090-A2 (EP)
Inventor: MATHIS HUGO DIPL ING
IPC: E04B7/10
Filed: 1983-07-08
Abstract: 1. A method of erecting a domed, conical, or pyramidal covering of concrete for structures above or below ground, in particular for tank-like structures, consecutively annular sections being produced starting from the upper edge of the enclosing wall of the structure, characterized in that consecutively annular sections (A, B, C) are produced with an annular overlying and/or underlying support (3) formed at the inner edge in each case, and as the first annular section (A) next to the enclosing wall (1) is erected radial supports (6) of a shuttering structure are supported on one side on the enclosing wall (1) and on the other side on a support structure (7, 8) extending at a distance parallel to the enclosing wall (1), and as the further annular sections (B, C) are erected the radial supports (6) are supported on one side at their inner ends on the support structure (7, 8) displaced towards the centre of the structure in accordance with the width of the section (B, C) and are suspended on the other side at their outer ends in the region of the overlying and/or underlying support (3) - provided on the edge - of the set annular section (A, B or C) of the covering.
Patent EP-0100944-A2 (EP)
Inventor: BRENNER PETER
IPC: B24C3/08
Filed: 1983-07-22
Abstract: 1. Conveyor means for a centrifugal blasting machine for cylinder blocks or similar workpieces with at least one blasting chamber and with a loading and unloading station, in which the conveyor means (2, 50) has workpiece reception means (9), each mounted in two opposite supports (7, 7a, 7b) and is rotatable about a rotation axis (13), whilst there is at least one clamping device (11), characterized in that a workpiece holder (10) connecting one of the two supports (7, 7a, 7b) is provided, that the clamping device (11) has at least one clamping shoe (16) located on a pivoted lever (15) and tensioned by means of a force accumulator (18, 18a), said clamping shoe pressing the workpiece or workpieces (3) against the workpiece holder (10), the pivoted lever (15) having at least one working surface (20) on which, at the loading and unloading station, acts an actuator (22) for raising the clamping shoe (16).
Patent EP-0102619-A2 (EP)
Inventor: MERK EDWARD
IPC: B23Q7/14
Filed: 1983-08-31
Abstract: A carousel pallet shuttle cooperates to move pallets (18) between individual ones of a plurality of pallet storage stations (12-17) located in a circular arrangement, and incorporates a rotatable support (10) with a shuttle member (20) mounted thereon. Pallets are movable onto the rotatable support, and are movable off of the rotatable support to a machining position. A latch (80) is provided with a linkage (52, 76-82) for automatically engaging the pallet before it is moved onto the rotatable member and disengaging it after the pallet is moved off of the rotatable member.
Patent EP-0117356-A2 (EP)
Inventor: MCALOON KEVIN THOMAS
IPC: C04B20/02
Filed: 1983-12-09
Abstract: A process for producing solid vermiculite products which are stable in water which comprises incorporating a source of ammonia or ammonium ions or a basic substance, preferably urea, in an aqueous suspension of vermiculite lamellae, shaping the suspension and removing water from the suspension by heating the shaped suspension at a temperature above 100°C, preferably above 150°C, such that ammonia or a basic substance is liberated within the suspension. The invention includes an aqueous suspension of vermiculite lamellae containing a source of ammonia or ammonium ions or a basic substance and a dry-powder mixture of vermiculite lamellae and a source of ammonia or ammonium ions or a basic substance.
Patent EP-0121828-A2 (EP)
Title: Alcools aliphatiques, leur préparation et leur utilisation à titre d'ingrédients parfumants
Inventor: SCHULTE-ELTE KARL-HEINRICH DR
IPC: C07C45/62
Filed: 1984-03-16
Abstract: On décrit des alcools cycloaliphatiques nouveaux de formule <IMAGE> dans laquelle chacun des symboles R¹ et R² sert à désigner un radical méthyle ou dans laquelle R¹ désigne un radical éthyle et R² un radical méthyle ou l'hydrogène, ainsi que leur utilisation à titre d'ingrédients parfumants. Les composés mentionnés développent en particulier des notes ambrées, boisées et animales.
Patent EP-0130560-A2 (EP)
Inventor: BACHLER SVEN DIPL-ING
IPC: H01H77/10
Filed: 1984-06-27
Abstract: Strombegrenzender Schalter mit mindestens zwei länglichen und seitlich neben- bzw. übereinander angeordneten Kontakten (2, 4), von welchen der eine Kontakt (4) drehbar gelagert ist, an seinem einen Ende (dem Kontaktende) eine Schaltstelle mit dem anderen Kontakt bildet und an seinem anderen Ende (dem Wurzelende) mit einem flexiblen Stromleiter (7) versehen ist. Gemäß der Erfindung befindet sich die Lagerstelle (5) des drehbaren Kontaktes (4) zwischen den beiden Enden des Kontaktes an einem beweglichen Arm (6) und ist derart angeordnet, daß der drehbare Kontakt bei einem Kurzschlußstrom unter der Wirkung elektrodynamischer Kräfte zunächst in einer ersten Richtung unter Beibehaltung des galvanischen Kontaktes an der Schaltstelle (2a, 4a) gedreht wird, wobei eine solche Änderung der Lage des beweglichen Arms (6) verursacht wird, daß der Abstand zwischen der Lagerstelle (5) des Kontaktes (4) und dem Gegenkontakt (2) größer wird. Ferner ist ein erster Anschlag (17) vorhanden, der die Drehbewegung des Kontaktes (4) in der ersten Drehrichtung begrenzt und eine Drehbewegung des Kontaktes in der entgegengesetzten Drehrichtung auslöst, die eine schlagartige Kontaktöffnung zur Folge hat.
Patent EP-0144855-A2 (EP)
Inventor: KRAUTKRAEMER GUENTER DIPL RER
IPC: B65D39/00
Filed: 1984-11-20
Abstract: A plastic closure is described for application to the edge, bent over in the axial direction, of an opening in the wall of a container, and for non-releasable connection to this, the closure (1) having a bearing flange (4), a bead-like projecting foot (6) and, between these and separating them, an annular groove (5). In order to improve the fit of the plastic closure without the necessary forces upon insertion of the closure becoming too high, it is provided, according to the invention, for the foot (6) to have on its periphery projecting notches (7, 7') arranged at a distance from one another. This leads to an improved securing of the closure in the top part of the container. In this way it is also possible to prevent the closure from being inadvertently pulled out from its secure fit upon pulling-up of the bellows-shaped pouring part of the closure. If filled containers are dropped, the new closure scarcely moves out at all from the opening when the latter is deformed by the drop. <IMAGE>
Patent EP-0117614-A2 (EP)
Inventor: NAGAMINE TSUYOSHI
IPC: G09G5/36
Filed: 1984-01-23
Abstract: A color display unit for numerical controllers is provided with means for displaying a finished shape (83), a finishing allowance profile (82), a blank profile (81), a tool profile (84) and a chuck profile (80) in painted-out graphic forms and in different colors, thereby facilitating their visual recognition.