Patent SG-11201808552X-A (SG)
Title: T-cell modulatory multimeric polypeptides and methods of use thereof
Inventor: SEIDEL III RONALD D
IPC: C12N15/63
Filed: 2017-05-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 0111011110111110101111111 011111111111011 1 111111101110 III 1111 III1 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201210 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: BORDEN, Paula A.; 201 Redwood Shores Park- A61K 39/395 (2006.01) CO7K 14/47 (2006.01) way, Suite 200, Redwood City, California 94065 (US). A61K 48/00 (2006.01) Cl 2N 15/63 (2006.01) CO7K 14/00 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/033187 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 17 May 2017 (17.05.2017) HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (25) Filing Language: English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (26) Publication Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/338,410 18 May 2016 (18.05.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: CUE BIOPHARMA, INC. [US/US]; 675 kind of regional protection available): ARIPO (BW, GH, West Kendall Street, Cambridge, Massachusetts 02142 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (US). UG, TM), ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: SEIDEL III, Ronald D.; 675 West Kendall EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — ge,ass Street, Cambridge, Massachusetts 02142 (US). CHAPAR- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, RO, Rodolfo; 675 West Kendall Street, Cambridge, Mass- achusetts 02142 (US). = Title: T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND (54) METHODS OF USE THEREOF = T Cell Modulatory = Domain Targeting Epitope = = = = = = = — _ C it = B2M = = = = T Cell Modulatory Domain — 1-1 Fc FIG. IC 0 1-1 ei 1-1 (57) : The present disclosure provides T-cell modulatory multimeric polypeptides comprising two different immunomodula- 0 el tory polypeptides, at least one of which is a variant immunomodulatory polypeptide. The present disclosure provides nucleic acids ----- comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. IN ,-1 The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T- 0 cell modulatory multimeric polypeptide of the present disclosure. ei C [Continued on next page] WO 2017/201210 Al MIDEDIMOMMIDIROFIEHIMIIMIHOMERVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))