Patent SG-11201908961Y-A (SG)
Title: Solvent-free method of encapsulating a hydrophobic active
Inventor: THONIYOT PRAVEEN
IPC: A61Q17/00
Filed: 2018-03-27
Abstract: O00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT ~~~~~ IIIIIl011101010VIIIOH olo onoiol ioo Homo iflo oimIE (10) International Publication Number WO 2018/182509 Al (51) International Patent Classification: A61K 47/10 (2017.01) A61Q 17/00 A61K 8/11 (2006.01) A61Q 19/00 A61K 9/107 (2006.01) A61P 17/00 A61K 9/51 (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/SG2018/050136 (22) International Filing Date: 27 March 2018 (27.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201702525X 28 March 2017 (28.03.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: THONIYOT, Praveen; c/o Institute of Chem- ical and Engineering Sciences, 1 Pesek Road, Jurong Is- land, Singapore 627833 (SG). KANAUJIA, Parijat; c/o Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore 627833 (SG). M. VAN HERK, Alexander; c/o Institute of Chemical and Engi- neering Sciences, 1 Pesek Road, Jurong Island, Singapore 627833 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: SOLVENT-FREE METHOD OF ENCAPSULATING A HYDROPHOBIC ACTIVE Self-Assembly in water mPEG-PCL + API in melt Active ingredient vv PCL mPEG Nanoparticle loaded with active ingredient FIG. 1 (57) : Present disclosure relates to a solvent- free method of encapsulating a hydrophobic active in personal care, hydrophobic active in crop protection or a hydrophobic active pharmaceutical ingredient (API) in polymeric nanoparticles. The method includes mixing the hydrophobic active in a polymer melt, wherein the polymer melt comprises a melt of a block co-polymer, wherein the polymer melt acts as a solvent for the hydrophobic active. The method further includes maintaining the polymer melt in water for sufficient time to allow self-assembly of the block co-polymer to encapsulate the hydrophobic active therein. [Continued on next page] WO 2018/182509 Al MIDEDIMOMMIDIREEMOMERIDENIEHOMEMOIS Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE