baber/WOPTO huggingface dataset:
Patent CA-2967554-A1 (CA)
Inventor: RUIKE YOSHINAO
IPC: C12N1/21
Filed: 2015-12-18
Abstract: La présente invention a pour objectif de fournir des anticorps anti-C5 et leurs procédés d'utilisation. L'invention concerne des anticorps anti-C5 et leurs procédés d'utilisation. Dans certains modes de réalisation, un anticorps anti-C5 isolé de la présente invention se fixe à un épitope à l'intérieur de la chaîne bêta de C5 avec une plus grande affinité à un pH neutre qu'à un pH acide. L'invention concerne également des acides nucléiques isolés codant pour un anticorps anti-C5 de la présente invention. L'invention concerne également des cellules hôtes comprenant un acide nucléique de la présente invention. L'invention concerne également un procédé de production d'un anticorps comprenant la culture d'une cellule hôte de la présente invention de manière à produire l'anticorps. L'invention concerne également un procédé de production d'un anticorps anti-C5 comprenant l'immunisation d'un animal contre un polypeptide qui comprend le domaine MG1-MG2 de la chaîne bêta de C5. Des anticorps anti-C5 de la présente invention peuvent être destinés à être utilisés comme médicament.
Patent CA-2968012-A1 (CA)
Title: Composition de revetement presentant un modificateur de rheologie
Inventor: BOOTH KARL A
IPC: C09D7/47
Filed: 2015-12-18
Abstract: L'invention concerne une composition de revêtement présentant un modificateur de rhéologie. Le modificateur de rhéologie est un polyuréthane soluble dans l'eau obtenu par la condensation d'un poly(alkylèneglycol), d'un polyisocyanate et d'un composé comprenant une chaîne polyalcoxylée et un groupe d'extrémité hydrophobe. La composition présente une résistance aux coulures Leneta supérieure à environ 14 et un écoulement et étalement Leneta d'au moins environ 9 et une viscosité Stormer inférieure à environ 120 unités Krebs.
Patent CA-2969805-A1 (CA)
Title: Seismic source installation/anchoring system and method
Inventor: ANDERSEN JAMES K
IPC: G01V1/133
Filed: 2017-06-06
Abstract: A vehicle hitch or tow bar can be used as an attachment point to a vehicle to provide weight to a seismic source system which includes at least one vibratory seismic source mounted to a shaft of pole and a mechanism for raising and/or lowering the shaft or pole for use in coupling a seismic source to the earth in conjunction with acoustic receivers for determining the lithology and for acoustic imaging of the subsurface of the earth.
Patent CA-2971238-A1 (CA)
Title: Recipient pre-rempli de toxine botulinique
Inventor: VOGT MARKUS
IPC: A61K9/00
Filed: 2015-12-22
Abstract: La présente invention concerne un récipient en verre pré-rempli, tel qu'une seringue en verre pré-remplie, comprenant une formule de toxine botulique aqueuse. La formule de toxine botulique aqueuse dans le récipient pré-rempli est stable à une température faible à ambiante pour une période de temps prolongée. En outre, la présente invention concerne un kit comprenant le récipient pré-rempli de toxine botulinique, et l'utilisation du récipient pré-rempli de toxine botulinique dans des applications thérapeutiques et cosmétiques.
Patent CA-2971544-A1 (CA)
Inventor: MITCHELTREE JEFF
IPC: B25B13/46
Filed: 2017-06-21
Abstract: Examples of the present disclosure relate to ratchets and include ratchets having a positive stop ratchet mechanism which controls the movement of a pawl and/or pusher with various geometric configurations and using various materials.
Patent CA-2977640-A1 (CA)
Inventor: MEADE JOHN C
IPC: A61B17/04
Filed: 2011-09-30
Abstract: Devices and methods for minimally invasive suturing are disclosed. One suturing device for minimally invasive suturing includes a proximal section a distal end, and an intermediate region therebetween. The device includes a suture head assembly having a suturing needle with a pointed end and a second end. The suturing needle is capable of rotating about an axis approximately perpendicular to a longitudinal axis of the device, wherein the pointed end of the suturing needle is positioned within the suture head assembly prior to deployment of guides that are adapted and configured to guide the needle around a circular path when advanced by a drive mechanism having a needle driver for engaging and rotating the suturing needle.
Patent CA-2978095-A1 (CA)
Inventor: WANG JUE
IPC: C12P21/00
Filed: 2016-03-11
Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.
Patent CA-2981821-A1 (CA)
Title: Novel antibodies inhibiting c-met dimerization, and uses thereof
Inventor: GOETSCH LILIANE
IPC: C12P21/08
Filed: 2008-07-10
Abstract: The present invention relates to a process for the selection of anti c-Met antibodies capable to inhibit both ligand-dependent and ligand-independent activation of c-Met. More particularly, said process is based on the inhibition of the c-Met dimerization. In another aspect, the present invention concerns such antibodies and compositions comprising such antibodies for the preparation of a medicament to treat cancer. Diagnosis process and kits are also part of the invention.
Patent CA-2988077-A1 (CA)
Title: Cable a fibres optiques ayant des elements d'ame lies
Inventor: BRINGUIER ANNE GERMAINE
IPC: G02B6/44
Filed: 2016-05-31
Abstract: La présente invention porte sur un câble de communication optique ainsi que sur des systèmes et sur des procédés associés. Le câble optique (10) comprend une pluralité d'éléments d'âme enveloppés (20, 22) et les surfaces externes des éléments d'âme enveloppés adjacents sont reliées les unes aux autres par des sections de liaison distincte (34). Les sections de liaison distincte (34) peuvent être des structures telles que des soudures laser, des soudures par ultrasons ou un matériau adhésif. Les liaisons distinctes (34) maintiennent ensemble les éléments d'âme enveloppés dans le motif enveloppé tel qu'un motif de câblage SZ.
Patent CA-2989820-A1 (CA)
Title: Systems and methods for securing magnetic coils in downhole linear motors
Inventor: KNAPP JOHN M
IPC: H02K15/06
Filed: 2016-06-16
Abstract: Systems and methods for securing coils of magnet wire to a support core in a linear motor that may be used, for example, in an ESP. In one embodiment, a hollow member such as a cylindrical metal tube is provided as a support core which is adapted to receive a mover of the linear motor. Coils of magnet wire are positioned at the exterior of the support core (e.g., wound around the core). An outer layer of shrink-wrap material is placed around the support core and coils and is heated, causing it to shrink and conform to the coils and the support core. The shrink-wrap material provides pressure against the coils which holds them securely against the support core. This assembly may then be positioned within a stator housing and secured to form the stator for the linear motor.
Patent CA-2991424-A1 (CA)
Inventor: SMITH W BRET
IPC: A61B17/88
Filed: 2016-07-14
Abstract: A bone positioning guide may include a main body member, a shaft, and a bone engagement member. The shaft can be movably connected to the main body member and have the bone engagement member rotatably coupled to its distal end. The bone engagement member can have a surface configured to engage a bone. The main body member can also include a tip opposite the bone engagement member for engaging a second bone. In use, the bone engagement member may be positioned in contact with a medial side of a first metatarsal while the tip is positioned in contact with a lateral side of a different metatarsal, such as a second metatarsal. The shaft can then be moved to advance the bone engagement member toward the tip, causing realignment of the first metatarsal.
Patent CA-2993797-A1 (CA)
Inventor: SHAHOSSEINI IMAN
IPC: B64D27/00
Filed: 2018-02-02
Abstract: The invention relates to a hydraulic torque compensation device comprising : - a first housing containing : a first piston comprised of a body and a rod, a first chamber arranged between said first body of the first piston and a first end of the first housing, said first chamber containing a high pressure liquid, a second chamber arranged between said body of the first piston and a second end, through which said rod of the first piston extends, of the first housing, said second chamber containing a low pressure liquid; - a second housing containing: a second piston comprised of a body and a rod, a wall extending through the whole section of said second housing, through which said rod of the second piston passes, a third chamber defined between said body of the second piston and said wall, said third chamber containing a high pressure liquid, a fourth chamber, with a variable volume, defined between said body of the second piston and a first end of the second housing, said fourth chamber containing a low pressure liquid, a fifth chamber defined between said wall and a second end, through which the rod of the second piston extends, of the second housing, said fifth chamber also comprising a low pressure liquid, such that the fourth and fifth chambers surround the third chamber, an auxiliary duct linking the fourth chamber and the fifth chamber; - a first main duct linking the first chamber, comprising a high pressure liquid, of the first housing to the third chamber, also comprising a high pressure liquid, of the second housing, - a second main duct linking the second chamber, comprising a low pressure liquid, of the first housing to the fifth chamber, also comprising a low pressure liquid, of the second housing.
Patent CA-2994521-A1 (CA)
Inventor: NITTA JUN
IPC: B21D19/08
Filed: 2016-09-02
Abstract: There is provided a hole widening method including a preparing process of preparing a forming tool which has a diameter-increasing portion increasing in diameter from a front end side toward a rear end side and a line-shaped projection formed to protrude outward from a surface of the diameter-increasing portion, and a workpiece in which a pilot hole is formed; and a hole widening process of successively widening the pilot hole by pushing the forming tool into the pilot hole such that the line-shaped projection of the forming tool comes into point contact with a part of a circumferential edge portion of the pilot hole in the workpiece two times or more, and forming a stretched flange.
Patent CA-2999140-A1 (CA)
Inventor: ALMOG TAL
IPC: C12N5/0775
Filed: 2016-09-22
Abstract: Methods for propagating mesenchymal stem cells (MSC), and particularly adipose derived stem cells, comprising incubating isolated cells obtained from a tissue or organ comprising MSC in a growth medium comprising an apoptosis inducing agent, under specified conditions. The invention further concerns the isolated cell population and kits for performing the methods.
Patent CA-2999912-A1 (CA)
Inventor: KHALILI KAMEL
IPC: C12Q1/68
Filed: 2016-09-23
Abstract: The present disclosure provides compositions and methods for specific cleavage of target sequences in retroviruses, for example human immunodeficiency virus (HIV-1). The compositions, which can include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a human immunodeficiency virus, can be delivered to the cells of a subject having or at risk for contracting an HIV infection.
Patent CA-3002186-A1 (CA)
Title: Aerodynamic drag monitoring system and method
Inventor: CRAWFORD CURRAN
IPC: G01M9/06
Filed: 2018-04-19
Abstract: Described are various embodiments of an aerodynamic drag monitoring system and method.
Patent CA-3002323-A1 (CA)
Inventor: FICHERA EPIFANIO
IPC: A61K39/015
Filed: 2016-10-17
Abstract: The present invention relates to certain polyphenol(s) having adjuvant property that can be used for the vaccine preparation. Also, the current invention provides adjuvant system comprising said polyphenol(s) and delivery system such as an immunostimulating reconstituted influenza virosomes (IRIVs). The present invention illustrates the said polyphenol(s) or an adjuvant system comprising of such polyphenol(s) and IRIVs can provide better level of immune response against antigen of interest than conventional vaccine systems. The preferred polyphenol according to the present invention can be beta-sitosterol. Beta-sitosterol can be optionally combined with the known adjuvant(s) to enhance immune response.
Patent CA-3002456-A1 (CA)
Title: Autocuiseur a micro-ondes comportant des mecanismes de blocage de securite
Inventor: BACKAERT DIMITRI M C J
IPC: B65D81/34
Filed: 2014-05-09
Abstract: La présente invention concerne de manière générale des ustensiles de cuisson et des autocuiseurs pour aliments. Les autocuiseurs à micro-ondes connus ne se prêtent pas aux dispositifs de verrouillage existants. Un objet de la présente invention est de proposer un autocuiseur à micro-ondes offrant des fonctionnalités de verrouillage de sécurité. Un mode de réalisation de la présente invention concerne un récipient pouvant être chauffé, comprenant une base, un couvercle, une ouverture dans le couvercle et une tige indicatrice prévue dans l'ouverture, dans laquelle un moyen est prévu pour permettre la communication de fluide avec l'atmosphère lorsqu'il est dans une position de repos, dans laquelle le moyen pour permettre la communication de fluide avec l'atmosphère dans ladite position de repos comprend de préférence au moins un rebord prévu dans l'ouverture ou au moins deux rebords prévus dans l'ouverture, et de préférence au moins deux rebords sont situés sur la tige indicatrice.
Patent CA-3006258-A1 (CA)
Title: Systems and methods for a hand-controllable surgical illumination device
Inventor: MIRSEPASSI ALIREZA
IPC: A61B90/30
Filed: 2016-12-13
Abstract: An exemplary illumination system is provided herein for use in performing an ophthalmic surgical procedure. The illumination system may include a body configured to be held by a hand of a user. The body may include an outer surface and an inner surface that defines an inner chamber. The exemplary illumination system may further include an elongate tubular member extending from a distal end of the body, which may have an illumination path within a lumen of the elongate tubular member, and an illumination source coupled to the illumination path through an optical fiber extending between the body and a surgical console. The exemplary illumination system may include a plurality of illumination controls disposed on the outer surface of the body. A first illumination control may permit the user to selectively control an adjustable illumination level between a high intensity state and a low intensity state.
Patent CA-3006683-A1 (CA)
Title: Benzopiperidine derivative, preparation method thereof and medical use thereof
Inventor: YANG FANGLONG
IPC: A61P35/00
Filed: 2016-12-02
Abstract: The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention relates to a benzopiperidine derivative as shown by general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative, as well as a use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor-mediated or dependent diseases or conditions. Preferably, the disease is breast cancer. The substituents in general formula (I) are the same as those defined in the description.
Patent CA-3007017-A1 (CA)
Inventor: WANG DAOMIN
IPC: G02C5/02
Filed: 2016-07-14
Abstract: An eye glasses processing method of a metal sheet wrapping a surface of an acetate sheet, the method comprises the following steps: (1) cutting and finely carving a 4.0 acetate sheet; (2) baking the acetate sheet till soft, and tapping a steel needle into the acetate sheet; (3) finely carving grooves on both sides, and clamping a metal accessory on an acetate blank; (4) mounting an upper mold and a lower mold on a 15-ton hydraulic machine; (5) clamping metal in the grooves carved on the acetate blank, and sleeving the same on a medium-pressure mold to be placed in an oven for heating; (6) placing the acetate sheet into a sealed oven to be heated and baked; (7) after the acetate sheet is completely softened, sleeving the acetate sheet and the medium-pressure mold into a lower pressure mold in an oil press, and pressure is adjusted to 1 ton for direct pressing; (8) removing, and using a waterproof abrasive paper machine to polish off the excess acetate material and metal; (9) after completing the process of pressing the metals onto the acetate blank, performing subsequent processes according to traditional methods with respect to other eye glasses-making processes, thus obtaining a finished eye glasses product.
Patent CA-3007900-A1 (CA)
Title: Microcapsules de thrombine
Inventor: ILAN EREZ
IPC: A61K38/48
Filed: 2016-12-01
Abstract: L'invention concerne des poudres de thrombine desséchées par pulvérisation comprenant des microcapsules, des procédés de préparation et leurs utilisations.
Patent CA-3010301-A1 (CA)
Title: Accurate caching in adaptive video streaming
Inventor: SU CHI-JIUN
IPC: G06F15/16
Filed: 2016-12-31
Abstract: An approach for cached content identification for adaptive data streaming. A  first request is received, requesting a current segment from a sequence of segments from a data file of a streaming data session. A NewVideoFlag is determined as indicating that the sequence of segments associated with the first request is not currently being cached. The first request is forwarded to a content server, and a first response message is received. A SegmentID of the received content segment is determined as not matching that of cached content segments. The NewVideoFlag is set to indicate that the segments from the streaming data session file are currently being cached. A global cVideoFilelD is generated identifying the streaming session data file being cached. The content segment is cached, and cache bookkeeping is updated to associate the segment with the SegmentID and the cVideoFilelD. The first response message is provided to the client device.
Patent CA-3010437-A1 (CA)
Title: Systeme de traitement de donnees communiquant avec un systeme de traitement de donnees cartographiques de facon a generer un affichage d'un ou plusieurs segments d'un ou plusieurs trajets d'un vehicule
Inventor: CHINTAKINDI SUNIL
IPC: G08G1/09
Filed: 2017-01-03
Abstract: L'invention concerne des systèmes et des procédés de génération d'un affichage d'une carte de navigation. Le système peut comprendre : un dispositif source de données historiques comportant par exemple un ordinateur source de données historiques et une base de données stockant des données historiques associées à des données d'accidents de véhicules et/ou des données de trafic et/ou des données de volumes de véhicules et/ou des données de densités de véhicules et/ou des données de caractéristiques routières et/ou des données météorologiques ; et un dispositif de traitement de données cartographiques comportant un ordinateur de traitement de données cartographiques et une mémoire stockant des instructions exécutables par ordinateur qui, lorsqu'elles sont exécutées par l'ordinateur de traitement de données cartographiques, amènent le dispositif de traitement de données cartographiques à déterminer par exemple un emplacement d'un véhicule sur la base d'un dispositif de détermination d'emplacement. Le système de traitement de données cartographiques peut : déterminer un ou plusieurs facteurs historiques sur la base de l'emplacement du véhicule ; recevoir des données historiques associées auxdits un ou plusieurs facteurs historiques, provenant du dispositif source de données historiques et relatives à l'emplacement ; calculer un ou plusieurs facteurs en temps réel et des données en temps réel associées auxdits un ou plusieurs facteurs en temps réel sur la base de l'emplacement du véhicule ; à l'aide desdits un ou plusieurs facteurs historiques et desdits un ou plusieurs facteurs en temps réel, calculer un score de navigation pour chaque segment d'un trajet allant de l'emplacement à un emplacement de destination ; puis déterminer une ou plusieurs couleurs pour chaque score de navigation et/ou générer un affichage d'une carte de navigation contenant lesdites une ou plusieurs couleurs.
Patent CA-3010628-A1 (CA)
Title: Novel cas9 systems and methods of use
Inventor: CIGAN ANDREW MARK
IPC: C12N15/113
Filed: 2017-02-27
Abstract: Compositions and methods are provided for novel Cas9 systems, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell. Also provided are nucleic acid constructs and cells having an altered target site or altered polynucleotide of interest produced by the methods described herein.
Patent CA-3011389-A1 (CA)
Inventor: DUBIEL DAVID
IPC: B01F5/06
Filed: 2018-07-16
Abstract: A fluid injection device includes a housing and a valve stem. The housing includes an inlet arm having an inlet orifice for receiving a feeder fluid. An outlet arm has an outlet orifice to discharge a mixed fluid. A venturi tube is between the inlet and outlet arms. The inlet arm, veturi tube and outlet arm define a nonlinear fluid pathway where the venturi tube redefines a portion of the nonlinear fluid pathway as a constricted fluid pathway. A diverter port is used to divert a portion of the feeder fluid from the inlet arm into the container and an injection port is used to receive product from the container. A valve arm is collinearly aligned with the venturi tube and the valve stem is positioned within the valve arm and adjusts the volume of the constricted fluid pathway.
Patent CA-3016916-A1 (CA)
Inventor: ALLETTO EUGENE
IPC: A47C27/06
Filed: 2017-06-06
Abstract: A spring assembly (30) is provided that includes a plurality of first strings (32, 66) of springs (64) and a plurality of second strings (32, 66) of springs (64). Each of the first strings are joined to at least another one of the first strings or one of the second strings. Each of the first strings includes first (34) and second plies (36) of fabric that define a plurality of pockets formed along a length of the first string. The pockets are formed by vertical seams (46) that join the plies. The vertical seams each include an upper slit (60) that extends through a top surface of the first string and a lower slit (62) that extends through a bottom surface of the first string. Each of the pockets have at least one spring (64) positioned therein.
Patent CA-3018518-A1 (CA)
Inventor: STAHL HEIKO
IPC: H01L21/30
Filed: 2018-09-25
Abstract: The invention relates to a method for producing at least one via in a wafer, comprising the following steps: - providing a wafer, comprising silicon, - producing a conductive region, in particular in the form of a conductor track, preferably composed of polycrystalline silicon, in the wafer, - producing a hole in the wafer, in such a way that the hole is fluidically at least partly connected to the conductive region and the sidewalls of the hole comprise silicon, - applying a tungsten hexafluoride-resistant protective layer, produced in particular from silicon oxide, in the region of the surface of the hole that is to be produced or has been produced, such that an opening of the hole that is to be produced or has been produced is free of a protective layer, and - applying tungsten hexafluoride to the hole and the region of the opening of the hole by means of a reducing-agent-free vapor phase deposition process, preferably in the form of a CVD process, for producing the at least one via.