Patent SG-11201811482Y-A (SG)
Title: Double targeted constructs to affect tumor kill
Inventor: BABICH JOHN W
IPC: A61P35/00
Filed: 2017-06-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1 MEM 0 11101 HOE 010 1111 1 0 01 OH 0111 HOME EH 1111 MI International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/223357 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: MEARA, Joseph P. et al.; FOLEY & LARDNER A61K 51/08 (2006.01) A61P 35/00 (2006.01) LLP, 3000 K Street NW, Suite 600, Washington, District of (21) International Application Number: Columbia 20007 (US). PCT/US2017/038832 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: 22 June 2017 (22.06.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (25) Filing Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (26) Publication Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: 62/353,735 23 June 2016 (23.06.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: CORNELL UNIVERSITY [US/US]; Center for Technology Licensing (CTL), 395 Pine Tree Road, Suite TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 310, Ithaca, New York 14850 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, — (72) Inventors: BABICH, John W.; 500 E. 83rd Street, Apt. 10C, New York, New York 10028 (US). KELLY, James M.; c/o Cornell University, CTL, 395 Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). AMOR-COARASA, Alejandro; c/o Cornell University, CTL, 395 Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). PON- NALA, Shashikanth; c/o Cornell University, CTL, 395 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). = (54) Title: DOUBLE TARGETED CONSTRUCTS TO AFFECT TUMOR KILL (57) : The present technology is directed to compounds, com- = 0O212' positions, medicaments, and methods related to the treatment of cancers expressing PSMA. The compounds are of Formulas I & II, or pharma- ceutically acceptable salts thereof. The present technology is especially well-suited for use in treating prostate cancer. = = = = = • /2 11' = = = A . = — = rr _ 1-1 • IN in en M ei ei N 11 FIG. 7A © ei O [Continued on next page] WO 2017/223357 Al MIDEDIM01101010111010111001011011110M100H1110VOIMIE Published: — with international search report (Art. 21(3))