baber/WOPTO huggingface dataset:
Patent CA-3031792-A1 (CA)
Inventor: SUBRAMANYAM MEENA
IPC: C07K16/28
Filed: 2006-04-04
Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre.
Patent CA-3032004-A1 (CA)
Inventor: BORODY THOMAS JULIUS
IPC: A61P1/00
Filed: 2017-08-02
Abstract: The present disclosure provides methods and treatment regimens for treating ulcerative colitis in a subject in need thereof. In particular, the methods described herein comprise treating a subject in need thereof with a treatment regimen comprising the administration of a pharmaceutical composition comprising live non-pathogenic fecal bacteria for at least 8 weeks and at least three times per week. In an aspect, the subject in need thereof exhibits a Mayo endoscopy score of 3 or lower. In some aspects, the subject in need thereof has no concomitant corticosteroid use during said method and has no corticosteroid use immediately prior to commencing said method.
Patent CA-3032350-A1 (CA)
Title: Diagnosis, treatment and prevention of neurotensin receptor-related conditions
Inventor: PRANTE OLAF
IPC: A61P35/00
Filed: 2017-08-02
Abstract: The present invention describes a compound of formula (I) which can be used in the diagnosis, treatment or prevention of neurotensin receptor-related conditions such as tumors and hematological malignancies.
Patent CA-3032857-A1 (CA)
Title: Boom mower
Inventor: HOFFMAN MICHAEL S
IPC: A01D34/835
Filed: 2019-02-05
Abstract: A boom mower attachment that moves a cutting mechanism in a first movement, a second movement, and a third movement by only using two motions of a single control and method of use thereof is provided. The boom mower may include a frame, a boom assembly carried by the frame, a cutting mechanism operably engaged with the boom assembly, and at least one translation assembly operably engaged with the boom assembly and the cutting mechanism that moves the cutting mechanism in one or more of the first movement, the second movement, and the third movement. An implement control system including a control, at least one function switching mechanism, and an implement is also provided. Activation of the control is operative to move the implement in a first mode, a second mode, and a third mode by only using two motions of the control.
Patent CA-3033429-A1 (CA)
Inventor: HUNGENBERG HEIKE
IPC: A01P7/04
Filed: 2011-11-30
Abstract: There are provided novel active ingredient combinations which consists of fluopyram and other known active ingredients and are very well suited for the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in the treatment of seeds, and are also suitable for increasing yields. There are also provided active ingredient combinations comprising N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-trifluoromethylbenzamide of formula (I)   (fluopyram) and N-oxides thereof, and (II) at least one active insecticidal or nematicidal ingredient selected from the group consisting of Paecilomyces lilacinus (II-5) and Paecilomyces lilacinus strain 251 (II-6).
Patent CA-3033515-A1 (CA)
Title: Endoscopic suturing system having external instrument channel
Inventor: MITELBERG VLADIMIR
IPC: A61B1/012
Filed: 2017-08-09
Abstract: A distal cap apparatus for use with an endoscope, having a proximal end and a distal end and a longitudinal axis extending therebetween, includes a mount configured for mounting to the distal end of the endoscope, and a strap connected to the mount and configured for banding about the distal end of the endoscope when the distal end of the endoscope is received in the mount. The mount defines a strap slot configured to receive an end of the strap to configure the strap in the banded configuration. The strap may be elastic. The strap may be a continuous band. In one embodiment, a distal cap apparatus includes a mount having a strap and a buckle for adjusting a size of a loop formed at least partially by the strap about the distal end of the endoscope.
Patent CA-3034193-A1 (CA)
Inventor: HJORTESET JENS
IPC: H01M10/6561
Filed: 2019-02-19
Abstract: Marine energy storage unit with thermal runaway safety barriers to prevent cell temperature increase, said marine energy storage unit comprises at least one closed module cabinet (10) with a plurality of stacked battery cells (4) and an internal cooling system. The internal cooling system comprises an enclosed cabinet cooling circuit (3) with a water-to-air exchanger (20) for air cooling of the battery cells (4), and the water-to-air exchanger (20) is connected to a water-to-water heat exchanger (30) for receipt of water from an external source.
Patent CA-3036031-A1 (CA)
Inventor: JORDAN CRAIG T
IPC: A61K47/68
Filed: 2001-03-06
Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R.alpha. or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells. These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.
Patent CA-3036279-A1 (CA)
Inventor: MAGGU MANMEET SINGH
IPC: A61H3/00
Filed: 2017-09-07
Abstract: A mobile, modular and adjustable system for rehabilitation and/or mobility. The system comprises an outer frame and wheels. A pelvis support can be used for distributing weight of the user to the frame. A lower body attachment is movably attached to the outer frame. At least one motorized unit may also be provided, which comprises at least one actuator to assist movement of the user's hip and/or leg through the lower body attachment. A local and/or cloud-based artificial intelligence system can be used for controlling the function of the mobile system.
Patent CA-3039188-A1 (CA)
Title: Composes de trifluoroborate heteroaryle destines au traitement d'infections mycobacteriennes
Inventor: KANEKO TAKUSHI
IPC: C07F5/02
Filed: 2017-10-05
Abstract: La présente invention concerne des composés de formule (I) ainsi que leurs sels pharmaceutiquement acceptables, les substituants étant ceux divulgués dans la spécification. Ces composés, ainsi que les compositions pharmaceutiques les contenant, sont utiles pour le traitement de la tuberculose.
Patent CA-3039413-A1 (CA)
Inventor: SMALL-HOWARD ANDREA
IPC: A61K31/015
Filed: 2017-10-10
Abstract: Provided herein are cannabinoid-containing complex mixtures suitable for use as active pharmaceutical ingredients. The complex mixtures comprise at least a first major cannabinoid, at least a first minor cannabinoid, and optionally at least a first selected terpene. Also provided are methods of making the complex mixtures; pharmaceutical compositions comprising the complex mixture, and methods of using the pharmaceutical compositions for the treatment of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Lewy Body Dementia, or Huntington's disease.
Patent CA-3039555-A1 (CA)
Inventor: NEIMAN YAKOV (JAKE)
IPC: A47F10/00
Filed: 2019-04-09
Abstract: A container is provided which is modified to operate for a secure business (e.g. a retail business for the sale of a restricted access product). The container has a first pair of opposing sides and a second pair of opposing sides with a first door leading into a security vestibule.  A second door is provided from the security vestibule into a restricted access space (e.g. an interior retail space, in which a restricted access product is displayed and available for sale).  A security checkpoint is provided in the security vestibule. The first door and the second door are offset from each other such that restricted access space is not visible to a visitor without passing the security checkpoint. A method of permitting access to a restricted access product for sale through a modified container is also provided.
Patent CA-3040033-A1 (CA)
Title: Double inhibiteurs de voies vista et pd -1
Inventor: SASIKUMAR POTTAYIL GOVINDAN NAIR
IPC: C07D271/06
Filed: 2017-10-18
Abstract: La présente invention concerne des composés 1,2,4-oxadiazole à substitution en position 3 et leurs dérivés, qui sont utiles en tant qu'inhibiteurs du suppresseur d'immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) ou en tant que double inhibiteurs de VISTA et de la voie de signalisation de la mort cellulaire programmée 1 (PD -1). L'invention concerne également le traitement de troubles par inhibition d'un signal immunosuppresseur induit par VISTA et ses ligands, PD -1, PD-L1, et/ou PD-L2.
Patent CA-3041414-A1 (CA)
Title: Outil et dispositif permettant d'enlever de la matiere de surfaces
Inventor: BOERSCH FABIAN
IPC: B28D1/04
Filed: 2017-11-02
Abstract: L'invention concerne un outil et un dispositif permettant d'enlever de la matière de la surface de murs, de plafonds et de sols, même dans les angles d'espaces intérieurs contaminés.
Patent CA-3044607-A1 (CA)
Title: Conveyor roller with conical tapered element
Inventor: LANGENSIEPEN DOMINIK
IPC: B65G39/04
Filed: 2017-12-15
Abstract: The invention relates to a conveyor roller (1) for conveyor systems for conveying containers, pallets, and the like, comprising a cylindrical roller body (2) with a rotational axis (Z), said roller body being provided for rotatably assembling in a frame or the like. One or more substantially truncated cone-shaped sleeves (12) are arranged on the roller body (2). The conveyor roller (1) according to the invention is characterized by a positioning device, by means of which the sleeve (12) is axially fixed at least along the rotational axis (Z) and in the direction of the sleeve cone tip (16), wherein the positioning device comprises a projection (40) which extends radially on the roller body (2) and into a recess (42) formed in the sleeve (12). The invention additionally relates to a method for producing such a conveyor roller (1).
Patent CA-3046269-A1 (CA)
Inventor: CERVINKA ALEXANDRE
IPC: E21F11/00
Filed: 2017-12-06
Abstract: La présente invention concerne un dispositif de sécurité conçu pour empêcher des travailleurs de passer dans un environnement dangereux, tel que sous terre, en utilisant le dispositif de sécurité défaillant. Du fait qu'un dispositif de sécurité, généralement une lampe au chapeau, doit être chargé avant chaque utilisation, le dispositif est conçu pour détecter l'instant auquel le dispositif est retiré du chargeur. Le dispositif commence à clignoter en continu lorsqu'il est déconnecté du chargeur. Une procédure d'essai automatisée est achevée sur le dispositif. L'utilisateur peut également terminer une partie manuelle de la procédure d'essai pour rendre le dispositif utilisable. Lorsque la procédure d'essai est achevée avec succès, la lampe arrête de clignoter. Si la procédure d'essai n'est pas réussie, la lampe continue de clignoter pour empêcher efficacement l'utilisateur d'utiliser un dispositif défaillant.
Patent CA-3047049-A1 (CA)
Inventor: TSUN ANDY
IPC: C12N15/13
Filed: 2017-12-22
Abstract: The present invention provides an antibody that specifically binds to proprotein convertase subtilisin/kexin type 9 (PCSK9), an antigen-binding fragment of the antibody, and a composition comprising the antibody or the fragment. Also provided are a nucleic acid that encodes the antibody or the fragment, a host cell containing the nucleic acid, and applications of the antibody and the fragment in treatment and diagnosis.
Patent CA-3048018-A1 (CA)
Title: Applicateurs et boitiers pour extensions de cils artificiels
Inventor: LOTTI SAHARA
IPC: B25B9/02
Filed: 2017-12-20
Abstract: Les boîtiers peuvent être utilisés pour loger des ensembles de cils artificiels dans un agencement spécifié. Par exemple, des fusions de cils peuvent être placées dans de multiples indentations prédéfinies sous la forme d'une paupière. Les applicateurs peuvent être utilisés pour saisir de manière élastique toutes les fusions de cils dans un ensemble d'extensions de cils, puis appliquer simultanément l'ensemble complet d'extensions de cils directement sur la face inférieure des cils naturels. L'invention concerne un applicateur comprenant des bras opposés qui sont reliés l'un à l'autre au niveau d'une extrémité interne conçue pour être saisie par un individu. L'applicateur peut également comprendre une extrémité externe ayant une forme concave qui est profilée pour être sensiblement alignée avec la forme convexe de la ligne de cils et les indentations prédéfinies d'un boîtier qui comprend l'ensemble d'extensions de cils.
Patent CA-3048563-A1 (CA)
Title: Kit for a hopper bottom of a particulate material storage container and related method
Inventor: HALFORD CHRISTOPHER J
IPC: B65D88/54
Filed: 2019-07-04
Abstract: A kit for forming a hopper bottom of a particulate material storage container comprises a generally conical lower section having a tapering diameter from a first end to the second end such that the second end is sized diametrically smaller, and a plurality of arcuate cone segments each defining an inclined concavely curved wall following a generally circular curvature, all of which can collectively form a hopper cone. The arcuate cone segments are connected in an annulus in which the walls of the arcuate cone segments collectively form a generally conical second cone section having a tapering diameter from one end to an opposite end which has a diameter substantially equal to that of the second end of the first cone section.  Afterwards, the opposite end of the formed second cone section is connected to the first end of the first cone section so as to form the hopper cone.
Patent CA-3048839-A1 (CA)
Inventor: VANDENBERG CHAD
IPC: H01F7/08
Filed: 2017-12-22
Abstract: A polarity-switching magnetic diode provides a method of gating or "rectifying" N and S polarized flux contained within the closed-loop flux circuit of a magnetic flux element. Gaps separate the opposing magnetic polarities, and strategically placed control coils are disposed to break the magnetic circuit in at least two places upon electrical activation of the device-forming high density flux zones of opposite polarity. Switching the control coil's magnetic flux flow allows for the high density flux zones to alternate N and S polarity.
Patent CA-3049377-A1 (CA)
Title: Activation de reservoir comportant une fracturation hydraulique realisee a l'aide de tunnels etendus
Inventor: LEE DONALD W
IPC: E21B43/26
Filed: 2018-01-04
Abstract: L'invention concerne une technique permettant de faciliter la production de fluide d'hydrocarbure. Un puits est formé dans une région souterraine par forage d'un trou de forage, par exemple d'un puits de forage généralement vertical. Au moins un tunnel est formé et orienté de manière à s'étendre vers l'extérieur depuis le trou de forage d'au moins 10 pieds dans une formation entourant le trou de forage. L'orientation dudit tunnel est sélectionnée de telle sorte qu'elle s'étend à un angle souhaité par rapport à une direction de contrainte horizontale dans la formation. Une activation de fracture dudit tunnel est réalisée pour créer un réseau de fractures. L'orientation dudit tunnel garantit que le réseau de fractures s'étend à travers une zone cible dans une région de la formation contenant des hydrocarbures.
Patent CA-3052066-A1 (CA)
Title: Composite core with reinforced areas and method
Inventor: BAKER LEONARD W
IPC: E04C2/00
Filed: 2018-01-30
Abstract: A method of producing a composite core member along a production line is disclosed. The core member is designed to be used within a composite panel of a tractor trailer. The method comprises the steps of providing an intermediate core member comprising a reinforced material positioned on at least one end of the intermediate core member and producing at least two strips of reinforced material. The intermediate core member is inserted between the strips of reinforced material and the strips of reinforced material are coupled to a first side and a second side of the intermediate core member to form the core member.
Patent CA-3053059-A1 (CA)
Title: Compounds for use in the prevention and/or treatment of non-alcoholic fat liver disease and non-alcoholic steatohepatitis
Inventor: AGREDA NAVAJAS JUAN CARLOS
IPC: A23L33/00
Filed: 2018-02-19
Abstract: Compounds of formula (I) and their pharmaceutical and food grade acceptable salts, for use in the prevention and/or treatment of NAFLD (non-alcoholic fat liver disease) or NASH (non-alcoholic steatohepatitis), and related symptoms and/or associated pathologies thereof are described. Also described are pharmaceutical compositions or nutraceutical compositions comprising said compounds of formula (I), and their pharmaceutically, or food grade, acceptable or allowable, salts and combinations thereof, optionally with any inert ingredient, carrier, excipient or alike for use in the prevention and/or treatment of NAFLD or NASH, and related symptoms and/or associated pathologies thereof. Additionally described are methods for the prevention and/or treatment of NAFLD or NASH, and related symptoms and/or associated pathologies thereof comprising the administration to a subject in need thereof, of any compound of formula (I), and pharmaceutical and food grade acceptable salts thereof, or any pharmaceutical compositions, functional food additives or nutraceutical compositions comprising the same.
Patent CA-3053078-A1 (CA)
Title: Agencement de flottation
Inventor: RINNE ANTTI
IPC: B03D1/14
Filed: 2018-02-14
Abstract: L'invention concerne un agencement de flottation servant à traiter des particules de minerai minéral en suspension dans une bouillie. L'agencement comprend une ligne de flottation primaire (10) ayant une partie de dégrossissage (11) et une partie épuiseuse (12). Le trop-plein d'au moins une cellule de flottation primaire de dégrossissage (111a) est destiné à s'écouler directement dans une cellule relaveuse de dégrossissage (210a). Une sousverse (42a) provenant d'une première cellule de flottation relaveuse est destinée à être combinée en trop-plein (51b) à partir d'une cellule de flottation primaire de dégrossissage en aval (111b) à partir de la cellule de flottation primaire de dégrossissage à partir de laquelle la première cellule de flottation de dégrossissage (210a) est conçue pour recevoir un trop-plein primaire (51a) ; ou en trop-pleins combinés (51b, 51c, 51d, 51e) à partir de cellules de flottation primaires de dégrossissage (111c, 111d, 111e) en aval de la cellule de flottation primaire de dégrossissage à partir de laquelle la première cellule de flottation de dégrossissage est conçue pour recevoir un trop-plein primaire ; ou en trop-plein (42b) à partir d'une cellule de dégrossissage supplémentaire (210b) conçue pour recevoir un trop-plein primaire à partir d'au moins une cellule de flottation primaire de dégrossissage en aval de la cellule de flottation primaire de dégrossissage à partir de laquelle la première cellule de flottation de dégrossissage est conçue pour recevoir un trop-plein primaire.
Patent CA-3056554-A1 (CA)
Inventor: ARGYROS AARON
IPC: C12N15/81
Filed: 2018-03-13
Abstract: The present disclosure concerns recombinant yeast host cells expressing cell-associated heterologous food and/or feed enzymes which are expressed during the propagation phase of the recombinant yeast hosts cells. The recombinant yeast host cells can be used in a subsequent production process to make food and/or feed products, for example, baked products.
Patent CA-3057897-A1 (CA)
Title: Apparatus and method for determining a predetermined characteristic related to an artificial bandwidth limitation processing of an audio signal
Inventor: GAMPP PATRICK
IPC: G10L25/69
Filed: 2018-03-29
Abstract: An apparatus for determining a predetermined characteristic related to an artificial bandwidth limitation processing of an audio signal comprises a slope evaiuator configured for evaluating a slope of a spectrum of the audio signal to obtain a slope evaluation result. The apparatus comprises a frequency evaiuator configured for evaluating a cut-off frequency of the spectrum of the audio signal to obtain a frequency evaluation result, and comprises a processor for providing an information indicating that the audio signal comprises the predetermined characteristic dependent on an evaluation of the slope evaluation result and an evaluation of the frequency evaluation result.
Patent CA-3058654-A1 (CA)
Title: Methods and compositions for treating retina-associated disease using ccr3-inhibitors
Inventor: CORADINI LAURA
IPC: A61K31/4523
Filed: 2018-04-04
Abstract: Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.
Patent CA-3059486-A1 (CA)
Inventor: CLARK AUSTIN
IPC: E06B9/262
Filed: 2019-10-21
Abstract: A spool box is configured to permit a change in the operation of a window covering from a manually-operated stated to a motorized state. The spool box may include a transfer drum, a coil spring drum, and a cord spool, together which permit the manual raising and lowering of the window covering. The spool box also may include an interface for coupling with a motorized converter module. When the spool box and motorized converter module are coupled, the window covering may be raised and lowered by a motorized operation.
Patent CA-3061563-A1 (CA)
Title: Good processing apparatus
Inventor: JAUERT JOACHIM
IPC: H04W88/16
Filed: 2019-11-13
Abstract: This invention relates to a good processing apparatus (GG) with a first communication module (KM1). The first communication module (KM1) is connected to a control unit (SE). The good processing apparatus (GG) is designed to accommodate at least one second communication module (KM2). The control unit (SE) is designed to determine whether the second communication module (KM2) is ready for operation.
Patent CA-3062951-A1 (CA)
Title: A personal transport apparatus
Inventor: KOCH JASON
IPC: A63C17/26
Filed: 2017-05-10
Abstract: A personal transport includes a deck configured for supporting a rider in a standing position. At least one wheel assembly is mounted on a bottom surface of the deck, the, or each, wheel assembly having at least one wheel so that the deck can travel over a substrate. An operator handle is substantially rigidly mounted on a rear end of the deck and extends rearwardly from the deck so that an operator, standing on the substrate, can grasp the operator handle and push the apparatus along the substrate, or tilt the apparatus relative to the substrate, while the rider is supported on the deck. A rider handle mounted on one of the deck and the operator handle and positioned so that the rider can grasp the rider handle for balance while supported by the deck.