baber/WOPTO huggingface dataset:
Patent CO-6361946-A2 (CO)
Title: Combuinaciones antitumorales que contienen anticuperos que reconocen especificamente cd38 y vincristina
Inventor: LEJEUNE PASCALE
IPC: A61K39/00
Filed: 2011-05-26
Abstract: 1.- Una combinación farmacéutica que comprende un anticuerpo que reconoce específicamente CD38 y al menos vincristina, en la que dicho anticuerpo puede destruir una célula CD38+ por apoptosis, citotoxicidad mediada por células dependientes de anticuerpos (ADCC) y citotoxicidad dependiente del complemento (CDC).2.- La combinación de la reivindicación 1, en la que dicho anticuerpo es un anticuerpo humanizado.3.- La combinación de la reivindicación 2, en la que dicho anticuerpo comprende uno o más regiones determinantes de la complementariedad que tiene una secuencia de aminoácidos seleccionada del grupo constituido por las SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35 y 36.4.- La combinación de la reivindicación 3, en la que dicho anticuerpo comprende al menos una cadena pesada y al menos una cadena ligera, en la que dicha cadena pesada tiene una secuencia de aminoácidos, representada por la SEQ ID NO: 66, y dicha cadena pesada comprende tres regiones secuenciales determinantes de la complementariedad que tienen las secuencias de aminoácidos representadas por las SEQ ID NOS: 13, 14 y 15, y en la que dicha cadena ligera tiene una secuencia de aminoácidos seleccionada del grupo de SEQ ID NOS: 62 y 64, y dicha cadena ligera comprende tres regiones secuenciales determinantes de la complementariedad que tienen secuencias de aminoácidos representadas por SEQ ID NOS: 16,17 y 18.
Patent CO-6551702-A2 (CO)
Title: Dispositivo de acceso
Inventor: HEDLEY ROBERT IAN
IPC: E06C1/38
Filed: 2012-05-23
Abstract: Un dispositivo de acceso (1) adaptado para suministrar acceso entre una superficie inferior (2) y una superficie elevada (3). El dispositivo de acceso (1) incluye un montaje (4), para el aseguramiento de dicho dispositivo (1) por debajo de una extremidad de dicha superficie elevada (3), un primer miembro de escalera (5), donde un primer extremo (9) del mismo está unido de forma pivotante a un extremo superior (11) de dicho montaje (4), un segundo miembro de escalera (6), donde un primer extremo (12) del mismo está unido de forma pivotante a un segundo extremo (13) de dicho primer miembro de escalera (5), medios de guía (7), operativamente conectados entre dicho montaje (4) y dicho primer miembro de escalera (5), para controlar el movimiento de dicho primer miembro de escalera (5) entre una posición de acceso y una posición de almacenamiento, y, un brazo guía (8), conectado operativamente entre un extremo inferior de dicho montaje (4) y dicho segundo miembro de escalera (6), para guiar el movimiento de dicho segundo miembro de escalera (6) a medida que dicho medio de guía (7) mueve dicho primer miembro de escalera (5). La operación del usuario de dichos medios de guía (7) controla la operación de dicho dispositivo de acceso (1) entre una posición de acceso y una posición de almacenamiento. En la posición de acceso, cada uno de dicho primer y segundo miembros de escalera (5 y 6) están sustancialmente alineados y se extienden angularmente hacia afuera y hacia abajo desde dicha superficie elevada (3). En la posición de almacenamiento, cada uno de dicho primer y segundo miembros de escalera (5 y 6) se retraen en una forma dispuesta sustancialmente vertical adyacente a dicho montaje (4), dicho segundo miembro de escalera (6) se encuentra sustancialmente invertido con relación a dicho primer miembro de escalera (5).
Patent CO-6592086-A2 (CO)
Title: Metodo para producir proteinas de interferon recombiantes solubles sin desnaturalizacion
Inventor: ALLEN JEFFREY
IPC: C07K14/555
Filed: 2012-08-28
Abstract: La presente invención se relaciona con la expresión de interferón en P. fluorescens y el desarrollo de un nuevo método para extraer proteínas activas a partir del producto de fermentación utilizando detergentes suaves y sin la necesidad de un proceso de replegado.Características de la Invención: La presente invención se relaciona con el campo de la producción de proteína recombinante en anfitriones bacterianos. Adicionalmente se relaciona con la extracción de la proteína recombinante activa, soluble de una fracción insoluble sin el uso de desnaturalización y sin la necesidad de una etapa de replegado. En particular, la presente invención se relaciona con un proceso de producción para obtener altos niveles de la proteína de interferón Tipo 1 recombinante soluble de un anfitrión bacteriano.Campo de Aplicación: Método para producir rápida y económicamente altos niveles de interferón-í3 recombinante soluble en células anfitrionas de mamífero o bacterianas, sin la necesidad de etapas de desnaturalización y replegado.”
Patent CO-7071136-A2 (CO)
Title: Métodos, composiciones y dispositivos para suministrar necesidades de ácido graso de la dieta
Inventor: MARGOLIN ALEXEY L
IPC: A23L33/00
Filed: 2014-09-17
Abstract: La presente invención se refiere a fórmulas nutricionales que comprenden ácidos grasos poliinsaturados de cadena larga (LC-PUFAs), junto con métodos y dispositivos para preparar y/o administrar las fórmulas nutricionales. En algunas modalidades, un porcentaje de los LC-PUFAs en la fórmula nutricional están en la forma de monoglicéridos y/o ácidos grasos libres. En algunas modalidades, las fórmulas nutricionales no comprenden lipasa agregada. También se proporcionan métodos para proporcionar nutrición a un sujeto, métodos para mejorar la absorción de grasa, métodos para mejorar la capacidad cognitiva, métodos para prevenir la enfermedad pulmonar crónica, y métodos para reducir la longitud de tiempo que un paciente requiere para nutrición parenteral total.
Patent EP-1031952-A2 (EP)
Inventor: NORDMANN KURT DR
IPC: G08B15/00
Filed: 2000-02-21
Abstract: The system has an optical monitoring unit (1) that can be moved along a path (5). The monitoring unit is carried by a carriage (3) that rolls or slides along a fixed guide track, e.g. a rail or rail network for rail carriages with at least one driven wheel.
Patent EP-1041512-A2 (EP)
Inventor: NICOM JACOB S
IPC: G06T11/20
Filed: 2000-03-03
Abstract: In a method for classifying line segment arrangements. A first line segment
has endpoints A and B and a second line segment has endpoints C and D. A
first triangle is traced along endpoints ABC, a second triangle is traced along
endpoints ABD, a third triangle is traced along endpoints CDA, and a fourth
triangle is traced along endpoints CDB. The signed areas of each of the four
triangles are determined from the coordinates of the triangles. The
arrangement of the line segments is classified according to the signed areas.
Patent EP-1134092-A2 (EP)
Inventor: HENTSCHEL GEORG
IPC: B44C5/04
Filed: 2000-04-12
Abstract: The method for producing an article displaying pictures or symbols involves production of a template with cutouts representing pictures or symbols to be displayed, gluing of this template to the rear side of a mirror, and removal of the reflective layer not covered by the template material by means of sandblasting.
Patent EP-1057469-A2 (EP)
Title: Verfahren zur dauerhaften Verformung von Keratinfasern
Inventor: SEIPEL WERNER
IPC: A61Q5/04
Filed: 2000-04-18
Abstract: Vorgeschlagen wird ein Verfahren zur dauerhaften Verformung von Keratinfasern, bei welchem man die Faser vor und/oder nach einer mechanischen Verformung mit einer wäßrigen Zubereitung einer keratinreduzierenden Substanz behandelt, nach einer Einwirkungszeit mit einer ersten Spülung spült, dann mit einer wäßrigen Zubereitung eines Oxidationsmittels fixiert und ebenfalls nach einer Einwirkungszeit spült, welches sich dadurch auszeichnet, daß die wäßrige Zubereitung der keratinreduzierenden Substanz und/oder des Oxidationsmittels (a) 0,1 bis 20 Gew.-% Zuckertenside ausgewählt aus der Gruppe, die gebildet wird von (a1) Alkyl- und/oder Alkenyloligoglykosiden und/oder (a2) Fettsäure-N-alkylpolyhydroxyalkylamiden und (b) 0,1 bis 20 Gew.-% Fettsäurepartialglyceride enthält, mit der Maßgabe, daß sich die Mengenangaben mit Wasser sowie gegebenenfalls weiteren Hilfs- und Zusatzstoffen zu 100 Gew.-% ergänzen.
Patent EP-1077325-A2 (EP)
Inventor: KRUSE BRIAN K
IPC: F02F3/22
Filed: 2000-07-26
Abstract: A one piece piston (20) for an internal
combustion engine (10) has a piston skirt (86) that is
connected to a flange portion (50) and a supporting
portion (42) of a piston body (34). The piston skirt
(86) provides support to the flange portion (50) and a
piston ring belt portion (52) disposed about and
connected to the piston body (34). The one piece
piston (20) has a closed piston cooling gallery (72)
defined by the piston body (34), the flange portion
(50) and piston ring belt portion (52).
Patent EP-1079344-A2 (EP)
Inventor: OKADA KAZUO
IPC: G07F17/32
Filed: 2000-08-17
Abstract: A game machine and a medium storing a game program
and readable by a computer, providing properly under an
appropriate circumstance a support, showing an excellent
navigation function, basically for beginners but not
forming unequalness to advanced players without
perverted equality between beginners and advanced
players and only the nominal support, not like the case
uniformly applying the support functions, wherein
actuation of a support means is allowed on the basis of
a latest game history going back from a latest time, so
that actuation of the support means is allowed or not
depending upon the latest game history, for example, when
the number of games under an internally determined Bonus
become larger than a predetermined value, wheels'
rotation number may be reduced, an aiming marker setting
allowed, wheels bands indicated laterally of simulated
wheels 3L, C, R, or results of internal winning
determination informed.
Patent EP-1093085-A2 (EP)
Inventor: SEILER LARRY D
IPC: G06T15/00
Filed: 2000-09-15
Abstract: A method renders a volume data set stored in a memory as voxels. A
rendering context is written to a controller. The volume data set is
partitioned, by the controller and according to the rendering context, into a
plurality of sections. Each section is aligned with a set of rays cast through
the volume data set. A visibility tests is performed on each section to
determine visible sections. Concurrently, voxel and sample visibility tests
are performed on each visible section to determine visible voxels and
samples, and only visible voxels are transferred to a particular one of a
plurality of rendering pipelines from the memory while issuing interpolate
commands for only the corresponding visible samples.
Patent EP-1020815-A2 (EP)
IPC: G06F11/26
Filed: 1997-04-18
Abstract: The automatic diagnosis process uses a system model for automatic simulation and diagnosis of the technical system, with model-based diagnosis software for generation of decision trees from model-based knowledge.  The diagnosis software may contain a reason maintenance system, with an interface and a control system between the latter and the inference machine.
Patent EP-1026516-A2 (EP)
Inventor: LIU YUJUN
IPC: G06T7/60
Filed: 2000-02-02
Abstract: The present disclosure teaches a system for analyzing ultrasonic image that
provides an output of a measurement of muscle width from an ultrasonic image input of an
outline of a muscle from an animal or carcass. The muscle that is used in the preferred
embodiment is the longissimus dorsi muscle when an ultrasonic scan is taken in a
transverse direction relative to the backbone. The analysis is done with a computer that
receives the electronic input of rows and columns of gray level pixel data from an
ultrasonic scan image of the outline of the muscle of the animal or carcass. The software
is set to select a region of the ultrasonic image input to analyze to determine a first edge of
the muscle. The selected region is divided into subregions Sj ,k . J designates a row and
ranges between 1 and n. K designates a column and ranges between 1 and o such that o is
greater than 1. The subregions are aligned in rows and columns throughout the ultrasonic
image input. The software calculates a sum of the gray level pixel data for each of the
subregions Sj,k then compares the sums to determine which of the subregions Sj,k has the
highest sum within each row j. The software defines a position of the first edge of the
muscle by comparing the highest sum within each row j. This position is then used to
calculate a relative muscle width when compared to a defined second edge of the muscle.
The second edge can be defined as one edge of the selected region of the ultrasonic image
input or it can be defined using the same steps used to define the first edge.
Patent EP-1027886-A2 (EP)
Inventor: BABCOCK WALTER CHRISTIAN
IPC: A61K9/16
Filed: 2000-02-02
Abstract: A composition comprises a solid dispersion
comprising a low-solubility drug and at least one
polymer. At least a major portion of the drug in the
dispersion is amorphous. The polymer has a glass
transition temperature of at least 100°C measured at a
relative humidity of fifty percent. Another aspect of
the invention comprises the same composition except that
the dispersion has a glass transition temperature of at
least 50°C at a relative humidity of fifty percent. In
another aspect of the invention, a composition comprises
a solid dispersion comprising a low-solubility drug and a
stabilizing polymer. At least a major portion of the
drug in the dispersion is amorphous. The composition
also includes a concentration-enhancing polymer that
increases the concentration of the drug in a use
environment. The stabilizing polymer has a glass
transition temperature that is greater than the glass
transition temperature of the concentration-enhancing
polymer at a relative humidity of 50%.
Patent EP-1050835-A2 (EP)
Inventor: WOODS SARAH
IPC: G06Q30/00
Filed: 2000-05-08
Abstract: A method of operating a loyalty-scheme involving one or more members and one or more
participating entities is provided. The method comprises issuing a token to which a certain
value is credited in response to a transaction with a participating entity and increasing the
value of that token in response to at least one further transaction with a participating entity.
The token is not associated with a specific member of the scheme. The method also comprises
providing one or more public terminals at which the value of the token can be determined and
exchanged for money or moneys worth, for example a voucher which can be exchanged for
goods or services.
Patent EP-1081660-A2 (EP)
Inventor: WETHERELL WILLIAM B
IPC: G02B27/10
Filed: 2000-08-30
Abstract: A document validation subassembly is described. The subassembly
includes a light mixer for generating at least one substantially homogenous light spot.
The light mixer includes a light mixing chamber, at least one input port for
accommodating at least one light source, at least one output, and at least one
collimator connected to the output. In an implementation, the light mixing chamber is
substantially spherical, but other shapes, such as cylindrical chambers, are also
contemplated. Also described are solid core light mixer implementations.
Patent EP-1085437-A2 (EP)
Inventor: MACKAY ROBIN
IPC: G06Q30/00
Filed: 2000-09-01
Abstract: A portable device comprising a processor, an amount of memory, and one or more
environmental sensors is carried about the body, and periodically data is recorded from the
sensors. When connected to a personal computer or the like, the records on the portable
device can be transferred to the personal computer, analysed, and used by an intelligent
agent application, enabling the application to provide the portable device with the
information necessary to alert the user when he/she is in a particular place at a particular
time.
Patent EP-1091291-A2 (EP)
Inventor: HERNANDEZ GASPAR III
IPC: G06F3/048
Filed: 2000-09-18
Abstract: For a large system having an associated monitoring system with one or more user
interfaces that each requires a large amount of direct user interaction, a scripting
language especially well suited to write a script (that generates liaison interface between
the user and the existing user interfaces) is provided. The liaison interface requires much
less direct user interaction by taking the place of the user in the extensive direct
interaction required by the existing user interfaces. Such a scripting language that
includes an integration construct data structure that permits commands of discrete
interfaces to be integrated in a single script that is to be executed by a machine. Also
provided are scripts according to the scripting language, that include at least two of the
integration construct data structures.
Patent EP-1069538-A2 (EP)
Inventor: WURZ NORMAN R
IPC: G07F17/32
Filed: 2000-06-26
Abstract: A gaming device comprises a cabinet with a hinged door, a gaming unit housed within the cabinet for playing a game, and a button panel system. The button panel system includes a printed circuit board mounted to the door and disposed inside the cabinet; a plurality of switches removably mounted to the printed circuit board; a button panel detachably mounted to the door in proximity to the printed circuit board and exposed to a player; a plurality of buttons mounted to the button panel in a preselected arrangement; and a plurality of actuators coupled to the respective buttons and disposed to actuate a group of the plurality of switches in response to pressing the respective buttons, the group of the plurality of switches cooperating with the game played by the gaming unit.
Patent EP-1096297-A2 (EP)
Inventor: SO VINCENT
IPC: G02F1/01
Filed: 2000-10-26
Abstract: An arrangement is provided having an optical
waveguide, a Chirp grating and an electro-optic material
arranged adjacent the Chirp grating, the electro-optic
material, for example liquid crystal material, having a
refractive index which can be varied by applying an electric
field to the material so as to control how the Chirp grating
interacts with the optical waveguide. The Chirp grating has a
spatial period that increases gradually along a length of the
grating. The arrangement may function as a wavelength
selective variable reflector, or as a wavelength selective
variable attenuator. The optical waveguide may have a region
of cladding made of the electro-optic material, with the Chirp
grating arranged adjacent the region of cladding to cause a
reflection of particular wavelengths of light when propagating
within the optical waveguide, the arrangement being adapted to
receive the applied electric field which controls how the Chirp
grating interacts with the waveguide.
Patent EP-1075001-A2 (EP)
Inventor: GRAF MICHAEL
IPC: H01F27/04
Filed: 2000-07-18
Abstract: The mains adapter has a transformer (1) with an iron core (2) and a primary winding and a secondary winding and a plastic cover (7) made in one piece that fully and closely encloses the transformer with the exception of the contact elements and connections (8a) that may be fed out through the cover. An Independent claim is also included for a method of manufacturing a mains adapter.
Patent EP-1156797-A2 (EP)
Inventor: MARCELLETTI JOHN F
IPC: A61K31/16
Filed: 2000-03-08
Abstract: The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically acceptable carrier. Methods for treating viral infections using such compositions are also disclosed.
Patent EP-1159405-A2 (EP)
Inventor: PLACHTER BODO
IPC: C12N7/01
Filed: 2000-03-02
Abstract: This invention relates to viral particles which are released by mammal cells after the infection with human cytomegalovirus (HCMV). The invention also relates to particles whose antigenicity has been optimized by changing the HCMV using genetic engineering. The invention further relates to the use of such particles as a vaccine and a method for multiplying the HCMV in mammal cells.
Patent EP-1236036-A2 (EP)
Inventor: LOXLEY NEIL
IPC: G21K5/02
Filed: 2000-11-23
Abstract: This invention relates to a portable apparatus for carrying out X-ray fluorescence spectrometry on specimen materials at a distance from the apparatus. The apparatus comprises an X-ray generating tube (1), such as a microfocus tube, and two paraboloidal X-ray reflecting mirrors. The first collecting mirror (11) is positioned in close coupled arrangement adjacent to the exit window (3) of the tube (1), such that it emits parallel X-ray radiation (14) to the second focusing mirror (12) which is aligned on the axis of and spaced apart from the first mirror (11). The second mirror (12) collects the parallel X-ray radiation (14) at its end closest to the first mirror (11) and emits X-ray radiation in a focused beam onto the specimen (20). The distance between the first and second mirrors is adjusted to suit the distance from the X-ray tube (1) to the specimen (20). Focal spots on the specimen (20) of diameter less than 15 νm are possible, enabling precise analysis of small areas of the specimen.
Patent EP-1118863-A2 (EP)
Inventor: FAUSER HANS-PETER
IPC: F16K31/06
Filed: 2001-01-04
Abstract: A movable piston (4) of flow regulating valve, is arranged in the front or rear side of the flow path. The moving position of piston is detected, by the non-contact type sensor (7). Based on the piston position, piston is regulated using spring (5). The piston is moved between the auxiliary and main flow paths, to vary the fluid flow. The flow path area is reduced by moving the piston, based on the detected piston position and pressure difference between the front and rear sides of piston.
Patent EP-1126546-A2 (EP)
Inventor: CAPPA GUIDO
IPC: B23K11/11
Filed: 2001-01-18
Abstract: The connector has a contact layer (2) containing a rare metal on a ceramic substrate (1), whereby the thickness of the contact film is less than that of the conductor. The conductor has at least two layers (3,4) of different thickness and different electrical specific resistance with the first layer (3) facing the contact layer having the lower specific resistance. The electrical connection between the conductor and the contact layer is made with gap welding Independent claims are also included for the following: a method of making an electrical connection and a use of the electrical connection for connecting a sensor in a vehicle.
Patent EP-1132654-A2 (EP)
Inventor: OHASHI TATSUYUKI
IPC: F16H59/08
Filed: 2001-02-22
Abstract: A shift control system is arranged such that a shift lever 201 is
movable to a "P" position, an "R" position, an "N" position, a "D5" position
and a "D4" position along a first shift guide path 211, it is movable also
from the "D4" position to a "3/M" position along a connection shift guide
path 212, and it is movable also along a second shift guide path 213, from
the "3/M" position into a direction different from that of the connection
shift guide path 212. When the shift lever is shifted to the "D5" position,
the transmission is set into an automatic shift control with forward drive
speed ratios up to the FIFTH speed ratio. When the shift lever is shifted
to the "D4" position, the transmission is set into an automatic shift control
with forward drive speed ratios up to the FOURTH speed ratio. When
the shift lever is shifted from the "D4" position to the "3/M" position along
the connection shift guide path 212, the transmission is set into a "3"
range, where an automatic shift control is executed with forward drive
speed ratios up to the THIRD speed ratio. Then, the shift lever at the
"3/M" position is swiveled along the second shift guide path 213 to shift
the speed ratio of the transmission manually in steps.