Patent SG-11201907492T-A (SG)
Title: Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Inventor: BRYS REGINALD
IPC: A61P37/06
Filed: 2018-02-15
Abstract: International Patent Classification: A61K 31/444 (2006.01) A61P 37/00 A61K 31/541 (2006.01) A61P 37/06 A61K 45/06 (2006.01) A61P 37/08 A61P 29/00 (2006.01) A61P 43/00 A61P 35/00 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: 9.0 .0 FIGURE (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIPO I PCT omit VIII °nolo 010 0111001001 OH IIII 1111101 ow (10) International Publication Number WO 2018/149925 Al PCT/EP2018/053803 (22) International Filing Date: 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1702603.0 17 February 2017 (17.02.2017) GB (71) Applicant: GALAPAGOS NV [BE/BE]; Generaal De Wittelaan L11/A3, 2800 Mechelen (BE). (72) Inventors: BRYS, Reginald, Christophe, Xavier; Gala- pagos NV Generaal De Wittelaan L 11/A3, 2800 Meche- len (BE). GALIEN, Rene, Alexandre; Galapagos SASU 102 Avenue Gaston Roussel, 93230 Romainville (FR). DE VOS, Steve, Irma, Joel; Galapagos NV Generaal De Wit- telaan L11/A3, 2800 Mechelen (BE). AMANTINI, David; Galapagos SASU 102 Avenue Gaston Roussel, 93230 Ro- mainville (FR). CLEMENT-LACROIX, Philippe; Gala- pagos SASU 102 Avenue Gaston Roussel, 93230 Ro- mainville (FR). (74) Agent: VERBEURE, Birgit; Galapagos NV Generaal de Wittelaan L11/A3, 2800 Mechelen (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, — (54) Title: ANTI-INFLAMMATORY COMPOSITIONS COMPRISING IRAK AND JAK INHIBITORS (57) : The present invention discloses compositions comprising com- pounds according to Formula I wherein R , and Cy are as defined herein, 1 , R 2 and a second compound having a JAK inhibiting activity. The present invention relates to composition, methods for their production, pharmaceutical composi- tions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoimmune diseases, proliferative diseases, allergic diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons by administering the compound of the invention 0. 31 32 33 34 35 36 37 38 39 40 41 42 43 days W O 20 18/1499 25 A Vehicle -t).-Cpd 1 (1 mg/kg) -x-Cpd 1 (3 mg/kg) -41-Cpd 1 (10 mg/kg) -4-Cpd 1 (30 mg/kg) [Continued on next page] WO 2018/149925 Al MIDEDIMOMOIDEIREEMOMOIDIEEIIIMODEVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(1i)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))