Patent SG-11201901445T-A (SG)
Title: A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
Inventor: WATSON PAUL
IPC: C07D231/14
Filed: 2017-08-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT omit °nolo oui lino Elio oimIE (10) International Publication Number WO 2018/039378 Al (51) International Patent Classification: C07D 231/14 (2006.01) A61P 3/00 (2006.01) A61K 31/415 (2006.01) A61P 27/02 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) (21) International Application Number: PCT/US2017/048267 (22) International Filing Date: 23 August 2017 (23.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/378,582 23 August 2016 (23.08.2016) US (71) Applicant: SAGE THERAPEUTICS, INC. [US/US]; 215 First Street, Cambridge, MA 02142 (US). (72) Inventors: WATSON, Paul, Steven; 104 Gateridge Place, Carrboro, NC 27510 (US). BERNER, Bret; 424 Lee Av- enue, Half Moon Bay, CA 94019 (US). REID, John, Gre- gory; 11849 Osprey Point Circle, Wellington, FL 33449 (US). WANG, Jian; 405 Mathers Lane, Branchburg, NJ 08853 (US). DOHERTY, James; 7 Foster Road, Bedford, MA 01730 (US). KANES, Stephen, Jay; 125 Guernsey Road, Swarthmore, PA 19081 (US). (74) Agent: MCCARTY, Catherine, M. et al.; Goodwin Proc- ter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 18/03937 8 Al (54) Title: A CRYSTALLINE 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID (57) : This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid 0 of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed here- CH3 N—N in are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21- pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21- pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof. 0 0 H 3 C OH H Formula (I) CN