baber/WOPTO huggingface dataset:
Patent PT-970070-E (PT)
Inventor: FREI JORG
IPC: A61K31/50
Filed: 1998-02-11
Abstract: The invention relates to compounds of formula I,wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R1 and R2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I*or (iii) together form a bridge in subformula I**wherein one or two of the ring members T1, T2, T3, and T4 are nitrogen, and the remainder are in each case CH; A, B, D, and E are N or CH, wherein not more than 2 of these radicals are N; G is lower alkylene, acyloxy- or hydroxy-lower alkylene, -CH2-O-, -CH2-S-, -CH2-NH-, oxa, thia, or imino; Q is methyl; R is H or lower alkyl; X is imino, oxa, or thia; Y is aryl, pyridyl, or (un)substituted cycloalkyl; and Z is mono- or disubstited amino, halogen, alkyl, substituted alkyl, hydroxy, etheritied or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N-mono- or N,N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl-lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl-lower alkylsulfonyl, or alkylphenylsulfony; and wherein the bonds characterized by a wavy line are either single or double bonds; or an N-oxide of said compound with the stipulation that, if Y is pyridyl or unsubstituted cycloalkyl, X is imino, and the remaining radicals are as defined, then G is selected from the group comprising lower alkylene, -CH2-O-, -CH2-S-, oxa and thia; or a salt thereof. The compounds inhibit angiogenesis.
Patent PT-914073-E (PT)
Inventor: GIEBELER WOLFGANG
IPC: A61F5/00
Filed: 1998-04-29
Abstract: PCT No. PCT/EP98/02521 Sec. 371 Date Dec. 28, 1998 Sec. 102(e) Date Dec. 28, 1998 PCT Filed Apr. 29, 1998 PCT Pub. No. WO98/49928 PCT Pub. Date Nov. 12, 1998A cervical brace includes a brace body which can be placed around the neck of a patient and fastened and unfastened at the narrow ends. Upper and lower rims of the brace body are adapted to fit the anatomy of the head and shoulder area around the neck respectively. The brace body includes upper and lower sections divided by a weakened zone or attenuation area. The brace body exhibits, at least over a portion of its length, a tapering curvature to its lower rim, so that the lower segment, upon application of the cervical brace, fits tightly around the entire base of the neck of the wearer.
Patent PT-1044439-E (PT)
Inventor: WESTRICK MICHAEL D
IPC: G08B21/02
Filed: 1998-12-03
Abstract: A person locating system (10) for detecting the unauthorized exit of a person from a monitored area (18) and locating the person thereafter, including a boundary transmitter (52) which generates an activation signal that is conducted across a conductor (16) connected to the boundary transmitter (36). The conductor (16) extends along a boundary of the monitored area (18) and transmits the activation signal within an activation zone (15) adjacent the conductor (16). The person to be monitored wears a portable module (22), which remains in a low power consumption, standby mode until the person enters the activation zone (15) adjacent the conductor (16). The portable module (22) receives the activation signal and enters an active mode wherein the portable module (22) transmits a high frequency locator signal (for example, 220 MHz). The locator signal is received by a locator receiver (28), which may be installed in a facility within the monitored area (18). The locator receiver (28) may also be portable so that the person to be monitored can be tracked down and recovered. In an alternate embodiment, the portable modules (22) are encoded with unique identification information which is transmitted as a part of the locator signal. The locator receiver (56) decodes this information and displays the identification of the wearer of the portable module (22) on a display (64).
Patent PT-1114076-E (PT)
Inventor: WIESENDANGER ROLF
IPC: C08G14/073
Filed: 1999-09-04
Abstract: Compounds active as accelerators for curable epoxy and polyurethane systems, those compounds having been prepared by means of a transamination reaction by reacting (a) a substituted phenolic compound (Mannich base) having at least one substituent of formulawherein R1 and R2 are each independently of the other linear or branched C1-4alkyl and R3 is hydrogen, methyl, ethyl or phenyl, with (b) a compound of formulawherein R4 and R5 are each independently of the other C1-C6alkyl or together form a radical of formula -(CH2)5- or -(CH2)2-O-(CH2)2-, n is an integer from 2 to 5 and q is zero, 1, 2 or 3, and the compound obtained or the compounds present in the mixture obtained has/have on average, per molecule, at least one substituent of formulaand the use of those compounds as accelerators in curable systems, preferably in curable epoxy and polyurethane systems.
Patent PT-1140088-E (PT)
Title: Controlled/modified release oral methylphenidate formulations
Inventor: KRISHNAMURTHY THINNAYAM N
IPC: A61K9/22
Filed: 1999-12-17
Abstract: The invention is directed to oral modified/controlled release methylphenidate formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release methylphenidate formulations, and the duration of effect falls rapidly at the end of the dosing interval so as not to affect the appetite of the patient at dinner nor the patient's sleep thereafter.
Patent IE-44727-L (IE)
Title: Dibenzothiophene derivatives
IPC: A61K31/381
Filed: 1977-03-23
Abstract: Dibenzothiophene derivatives which have anti-inflammatory activity and the formula <IMAGE> in which R is hydrogen, halogen, hydroxyl, cyano, lower alkyl, hydroxy-lower-alkyl, lower alkoxy, acyl, benzyloxy, lower alkylthio, trifluoromethyl, nitro, amino, mono-lower alkylamino, di-lower alkylamino, sulphamoyl, di-lower alkylsulphamoyl or difluoromethylsulphonyl; R1 is halogen, cyano, lower alkyl, hydroxy-lower alkyl, lower alkoxy, acyl, acylamido, benzyloxy, lower alkylthio, trifluoromethyl, hydroxyl, nitro, amino, mono-lower alkylamino, di-lower alkylamino, sulphamoyl, di-lower alkylsulphamoyl or difluoromethylsulphonyl, or R together with an adjacent R1 is alkylenedioxy, R2 is the group <IMAGE> where A is hydroxyl, lower alkoxy, amino-lower alkoxy, mono-lower alkylamino-lower alkoxy or di-lower alkylamino-lower alkoxy, X and Y are, independently of one another, hydrogen or lower alkyl, m is a number from 1 to 7, R2 is the group <IMAGE>, in which B is hydroxyl, carboxyl, lower alkoxy, amino, hydroxyamino, mono-lower alkylamino, di-lower alkylamino, amino-lower alkoxy, mono-lower alkylamino-lower alkoxy or di-lower alkylamino-lower alkoxy, Y and X are, independently of one another, hydrogen or lower alkyl, n is a number from 1 to 7, and pharmaceutically utilisable salts thereof are prepared by aromatisation starting from the corresponding 1,2,3,4-tetrahydrodibenzothiophene derivatives.
[GB1572358A]
Patent IE-42744-L (IE)
Title: Valves
IPC: F16K1/02
Filed: 1975-03-27
Abstract: A liquid outlet valve is adapted for connecting to a pipe. The valve has a throughhole member with an entry, an outlet and a passageway therethrough. A closure member is associated with the throughhole member to close off the outlet and an elastic flexible seal is provided in the closing member. A connecting means movably connects the closure member with the throughhole member to control the flow of liquid.
[US4003401A]
Patent IE-42912-L (IE)
Title: Pressure release valve
IPC: B05B11/00
Filed: 1975-04-08
Abstract: A valve intended to open in response to a pressure difference between the interior of the valve and the exterior thereof comprises a diaphragm which in its closing position is conical. The diaphragm has an opening which is normally closed by means of a valve stem. Arrangements are made to prevent communication between the interior of the valve and the exterior thereof until said diaphragm has been deformed to a substantially planar shape.
[US4061254A]
Patent IE-900921-L (IE)
Title: Pharmaceutical compositions
IPC: A61K31/00
Filed: 1990-03-14
Abstract: A composition is described for use in memory and learning enhancement or for treatment of a cognitive disorder or a psychotic disorder. This composition contains the compound D-cycloserine and D-alanine and provides reduced adverse side effects typically associated with chronic D-cycloserine use.
Patent IE-810993-L (IE)
Title: Coated edible product and process for its preparation
IPC: A23L13/50
Filed: 1981-05-06
Abstract: A sealed, coated edible product, which may be of animal or vegetable origin, is prepared by a process which comprises coating the product with a substantially fat-free batter containing flour, an aqueous liquid and optionally seasonings and between 0.5 and 10% by weight on a dry basis of an egg white substitute, especially one containing greater than 15% by weight of a globular proteinaceous material e.g. egg albumen which is soluble in water and coagulable by heat. Coated products so obtained retain a high proportion of their original moisture content upon subsequent cooking and/or chilling or freezing. The egg white substitute may be egg albumen extended with a proteinaceous or carbohydrate material, or a whey protein isolate.
[GB2097646A]
Patent FI-850884-L (FI)
Inventor: MOURRIER FRANCIS
IPC: B30B11/24
Filed: 1985-03-05
Abstract: The material-processing machine comprises at least a screw (11) driven in rotation inside a sleeve (1) and constituted by a central driving shaft (2) on which are mounted a plurality of screw elements (3) forming a stack of adjoining elements clamped between an abutment and clamping means placed respectively at the two ends of the shaft (2). The clamping means (4, 5) are arranged in such manner as to exert on the stack of screw elements (3) a prestressing force capable of opposing the separation of the screw elements (3) from each other in operation of the machine. The invention is especially applicable to the construction of screw extruders.
Patent IE-861004-L (IE)
Title: Octapeptides
IPC: A61K38/00
Filed: 1986-04-16
Abstract: Novel compositions of the formulawhereinA represents an L, D or DL amino-acid selected from the group consisting of Ala, Val, Phe, p-CI-Phe, Trp, Pro, Ser, Thr, Glu, Gly, Beta Ala, Abu, N-Me Ala, 5-F-Trp, 5-Br-Trp, 5-Cl-Trp, their acetylated derivatives or a pharmaceutically acceptable acid addition salt thereof;B represents an L, D or DL amino acid amide selected from the group consisting of Thr NH<sub>2</sub>, Val NH,, Pro NH<sub>2</sub>, HO-Pro NH<sub>2</sub>, Ser NH<sub>2</sub>, Tyr NH2, Trp NH<sub>2</sub>, 5-F-Trp NH,, For-Trp NH., Ala NH<sub>2</sub>, Gly NH2, Me Ala NH<sub>2</sub>;X represents L-Phe or L-Tyr,Y represents L-Thr or L-Val;Z is L, D or DL-5-F-Trp, 5-Br-Trp, 5-C1-Trp, 5-I-Trp or D-Trp; andC" and C' represent L or D Cys, Abu, Asp or Lys; provided that where C' is Cys, C" is also Cys and where C' or C" are other than Cys, C" is different from C' and is other than Cys and the pharmaceutically acceptable acid addition salts thereof; are useful as agents for inhibiting the release of growth hormone, for the treatment of gastrointestinal disorders and for therapy of certain cancers and the management of diabetes. These biologically active octapeptides all possess a terminal amino acid amide at position 8 and are prepared by solid phase methods.
Patent IE-36599-L (IE)
Title: Photoconductive oligomer
IPC: C08G16/02
Filed: 1972-07-25
Abstract: 1404829 Condensing pyrene with paraformaldehyde HOECHST AG 24 July 1972 [26 July 1971 10 June 1972] 34507/72 Heading C5E [Also in Divisions C2 and G2] Pyrene is reacted with paraformaldehyde in the presence of glacial acetic acid and zinc chloride to obtain a condensate containing about 6 to 8 pyrene units. The product is a photoconductor (see Division G2).
[GB1404829A]
Patent IE-39708-L (IE)
Title: Manufacture of slide fastener
IPC: B29D5/04
Filed: 1974-06-07
Abstract: Two synthetic-resin monofilaments are deposited from opposite sides on a continuously moving horizontal carrier strip provided with two rows of longitudinally spaced upstanding lugs disposed along opposite edges thereof. Each monofilament is entrained along an upwardly convex ridge of a respective guide element by a coacting transport element hugging that edge with a concave underside which has a bulge for deforming the filament to provide it with successive coupling heads, the transport elements being swingable in planes transverse to the carrier strip whereas the guide elements are vertically reciprocable to engage and disengage the respective monofilaments in timed relationship with the movement of the associated transport elements and the carrier strip between whose lugs these monofilaments are inserted in the form of narrow loops each carrying one coupling head.
[US3897192A]
Patent IE-32414-L (IE)
Title: Heterocyclic n-oxides
IPC: C08G73/14
Filed: 1968-10-10
Abstract: 1,238,954. N - Hydroxyalkyl - morpholine, piperidine and pyrrolidine N-oxides. COLGATEPALMOLIVE CO. 8 Oct., 1968 [24 Oct., 1967; 13 Nov., 1967], No. 47660/68. Heading C2C. [Also in Divisions A5 and C5] The invention comprises N-oxides of N- hydroxyalkyl morpholine, piperidine and pyrrolidine ; optionally substituted in the ring by C 1-3 alkyl groups, in which the hydroxyalkyl group contains at least 8 carbon atoms and the hydroxy group is attached to a carbon atom separated from the nitrogen atom by one or two methylene groups. The compounds are prepared by reacting the appropriate 1,2-epoxide or 1,3-oxetane with the required heterocyclic base, e.g., by heating underpressure, and oxidising the resultant N-2 or 3-hydroxy - alkyl compound, e.g., with hydrogen peroxide, to form the N- oxide. Preferred compounds are the 2-hydroxy- C 8-22 -alkyl morpholine oxides. The N-oxides possess foam-forming properties and are used in detergent compositions and in hair-shampoos and skin lotions to reduce skin-irritation (see Divisions A5 and C5).
[GB1238954A]
Patent IE-36925-L (IE)
Title: Tyres, carcass shaping
IPC: B29D30/24
Filed: 1972-09-08
Abstract: 1409555 Tyre building apparatus INDUSTRIE PIRELLI SpA 7 Sept 1972 [14 Sept 1971] 41501/72 Heading B7C A tyre building apparatus similar to that disclosed in patent Specification 1,182,061 comprises means 4, 9 for supporting the beads of a flat band carcass, and means for clamping the carcass ply or plies against the bead cores and preventing axial movement of the beads relative to the supporting means, the second means including two members 33, 34 which, when the carcass is expanded, squeeze only those portions of the carcass which extend from, and include, the beads to substantially half the height of the fully shaped carcass. As illustrated, the shaping is effected by supplying a compressed fluid, e.g. air, via port 50 and simultaneous approach of annular supports 4, 9. The member 34 may be secured to support 9 (as illustrated) for movement therewith, or may be rotatable and axially movable relative to that support. The member 33 is rotatable and axially movable relative to the support 4. Flexible diaphragm 5 is optional, and annular springs 21, 32, when radially expanded by outward axial movement of annular members 10, 22 relative to the supports due to supply of, e.g. air to spaces X, assist in clamping the beads and prevent their movement relative to the supports. Instead of the springs, the diaphragm may be suitably reinforced adjacent the supports. Tread and breaker supporting elements 37, 38 (or 51, 52, Fig. 7, not shown) integral with, or separate from (Fig. 7), the members 33, 34 may be provided. The carcass may be expanded by expansible rigid sectors instead of by inflation pressure as illustrated. The carcass may be built up on the apparatus.
[GB1409555A]
Patent IE-33607-L (IE)
Title: 19-norprogesterone derivatives
IPC: C07J75/00
Filed: 1969-09-09
Abstract: 1277886 14α,17α-(Substituted methylenedioxy)-androstenes KONINKLIJKE NEDERLANDSCHE GIST-EN SPIRITUSFABRIEK NV 10 Sept 1969 [11 Sept 1968] 43295/68 Heading C2U The invention comprises compounds of formula wherein R is C 1-5 aliphatic hydrocarbyl or is phenyl, and R<SP>2</SP> is Cl, Br, I or acetoxy. Compounds I wherein R<SP>2</SP> is acetoxy are prepared from 14α,17α-dihydroxyprogesterone by acetalization to introduce the desired 14,17- bridge, followed by conversion of the 20-oxo group to a hydroxyimino group (with temporary protection of 3-oxo-#<SP>4</SP> as 3-alkoxy#<SP>3</SP>'<SP>5</SP>), and then Beckmann rearrangement to give a 17#- acetamido group followed by reaction with e.g. nitrosyl chloride in acetic acid and acetic anhydride to give the desired 17#-acetoxy group. The final step may yield 14α-hydroxyandrost-4- ene-3,17-dione as a by-product. Compounds I wherein R<SP>2</SP> is Cl, Br or I are prepared from compounds of formula by a "modified Hunsdiecker reaction". Compounds VII are prepared from 14α,17α,21-trihydroxyprogesterone either by oxidation to give the 17#-carboxy group followed by acetalization, or by acetalization (preferably with temporary protection of 21-hydroxy as acetoxy) followed by oxidation to give the 17#-carboxy group. Compounds I are stated to possess progestational activity, and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration.
[GB1277886A]
Patent IE-38095-L (IE)
Title: Producing metal-containing compounds metallic powders
IPC: C01G41/00
Filed: 1973-08-16
Abstract: A process and apparatus for producing certain metal salts in very fine particulate form. The process comprises cooling a solution of metal salt until the solution freezes and thereafter evaporating the solvent under very low pressure. The process is particularly applicable to salts of tungsten and nickel from which sub-micron particles of tungsten and nickel can be produced.
[US3997331A]
Patent IE-831503-L (IE)
Title: Benzoquinolizines and pyridobenzoxazines.
IPC: C07D455/04
Filed: 1983-06-28
Abstract: Tricyclic compounds of formula (I) <CHEM> wherein: Z represents an oxygen atom or a methylene group, X1 represents a hydrogen atom or a halogen atom, R1 represents a cyclic amino group which may contain additonal hetero atom(s) of N,S and O and may be substituted with one or more substituents selected from the group consisiting of hydroxyl, amino, alkyl, mono- or di-alkylamino, hydroxyalkyl and aminoalkyl, and physiologically acceptable salts thereof, having antibacterial activity.
[EP0101829A2]
Patent IE-791578-L (IE)
Title: Acetylene derivatives of androstenes
IPC: A61P29/00
Filed: 1979-08-16
Abstract: Novel DELTA 4-androstenes of the formula <IMAGE> I' wherein R1 is alkyl of 1 to 3 carbon atoms, R' is an acyl of an organic carboxylic acid or carbonic acid of 1 to 18 carbon atoms, R2 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, alkenyl of 2 to 12 carbon atoms, -CF3, aryl of 6 to 12 carbon atoms and aralkyl of 7 to 12 carbon atoms, Y is selected from the group consisting of hydrogen, fluorine and methyl, X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine and the dotted lines in the A and B rings indicate one or 2 double bonds in 1(2) and 6(7) positions with the proviso when R1 is methyl and the B ring is saturated, X is hydrogen when Y is hydrogen and X is not hydrogen when Y is fluorine having a remarkable anti-inflammatory activity and their preparation.
[US4232015A]
Patent IE-45472-L (IE)
Title: Machine for casting plastics.
IPC: B29C37/00
Filed: 1977-08-22
Abstract: A machine for holding a release sheet on which emblem substrates are mounted while plastic is cast on the substrates and for holding the release sheet and substrates and curing the plastic includes a radiation source which is movable into a position above the release sheet. The platen holding the release sheet has a first cavity which is partially evacuated and which communicates with the upper surface of the platen through a plurality of openings. A second cavity in the platen receives temperature stabilizing fluid. Control circuitry is provided permitting alteration of the operation sequence of the machine.
[US4034708A]
Patent IE-821797-L (IE)
Title: 26,26,26,27,27,27-hexafluoro-1ó,25-dihydroxy-cholecalciferol¹derivatives
IPC: C07J9/00
Filed: 1982-07-26
Abstract: This invention provides a new derivative of vitamin D, 26,26,26,27,27,27-hexafluoro-1 alpha ,25-dihydroxycholecalciferol, a process for preparing the same, and novel intermediate compounds. The compound is characterized by vitamin D-like activity substantially greater than that exhibited by 1 alpha ,25-dihydroxycholecalciferol which is considered to be the active hormonal form of vitamin D. The compound would find ready application as a substitute for vitamin D and in the treatment of or prophylaxis for disease states evincing metabolic calcium and phosphorous deficiences or imbalances.
[US4358406A]
Patent IE-851941-L (IE)
Title: Compositions for skin treatment
IPC: A61K36/71
Filed: 1985-08-06
Abstract: A topical composition for skin treatment contains an anti-inflammatory glucocorticoid in combination with an essential fatty acid (EFA) of the n-6 or n-3 series or equivalent polyunsaturated fatty acid, as such or in the form of a physiologically acceptable derivative convertible in the body thereto.
[EP0173478A1]
Patent IE-791949-L (IE)
Title: Substituted 1-thia-3-aza-4-ones
IPC: A01N43/86
Filed: 1979-10-15
Abstract: Novel Pyridyl substituted thiazolidine and 1,3-thiazine derivatives having utility as plant fungicides, and terrestrial and aquatic plant growth regulators, with the formula <CHEM> wherein R is C3-C10alkyl, C3-C8-cycloalkyl, methallyl, phenyl, halophenyl, trifluoromethylphenyl, benzyl, methoxybenzyl, methylbenzyl, halobenzyl, dimethylaminoethyl, methylcyclohexyl, C3-C8cycloalkyl(C1-C3)alkyl, alpha -methylbenzyl, 2-thiazolyl, nitrophenyl, phenoxyphenyl, (tetrahydro-2-furanyl)-methyl, haloanlyl, trifluoromethylthiophenyl, methylthiophenyl, 2-norbornyl, furfuryl, 2-(1-methoxypropyl), methoxyphenyl, fluoro(C1-C2)alkoxyphenyl, 3-4-(methylenedioxy)phenyl, xlyl, biphenylyl, tolyl, or halotolyl; X is oxygen or sulfur; <CHEM> R<1> is hydrogen, methyl, or -S(C1-C6alkyl); R<2> is hydrogen, C1-C6alkyl, or -S(C1-C6alkyl); R<3> is hydrogen or methyl; R<4> is hydrogen or C1-C6alkyl; and R<5> is hydrogen or methyl. Methods for their preparation are described, e.g. 4-chloroaniline was reacted with 3-pyridine carboxaldehyde and the reaction mixture was reacted with thiolactic acid to give 3-(4-chlorophenyl)-5 -methyl-2-(3-pyridyl)-4-thiazolidinone.
[EP0010420A1]
Patent IE-41682-L (IE)
Title: Heat-shrinkable polymeric laminate and container sleeve¹formed therefrom
IPC: B65D23/08
Filed: 1975-09-09
Abstract: 1526944 Portable containers OWENSILLINOIS Inc 9 Sept 1975 [9 Sept 1974 6 March 1975] 36937/75 Heading B8D [Also in Division B5] A bottle 10 having a rim 14 defining a mouth opening, a bottom 18 and a wall 20 therebetween characterized by having a heat shrunk polymeric sleeve disposed outwardly of the wall and in snug engagement therewith which comprises a first closed cell layer of an olefine polymer and a second non-cellular layer of an olefine polymer in adhering contact with the first layer, either layer of the sleeve being in contact with the bottle.
[GB1526944A]