baber/WOPTO huggingface dataset:
Patent DK-1992695-T3 (DK)
Inventor: AFAR DANIEL E H
IPC: A61K35/76
Filed: 2000-08-11
Granted: 2011-02-14
Abstract: A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagnostic and/or therapeutic target for prostate cancer.
Patent DK-2065402-T3 (DK)
Inventor: CHOU MIN-YUAN
IPC: C07K16/32
Filed: 2008-01-23
Granted: 2018-07-02
Abstract: A collagen scaffold domain, including a collagenous or collagen-like domain, which directs self-trimerization is provided. The collagen scaffold domain can be fused to one or more heterologous domains, such as an antibody domain. Methods for generating and using the scaffold domains and fusion proteins are also provided.
Patent DK-2161052-T3 (DK)
Inventor: DUPIN THIERRY
IPC: A61M1/14
Filed: 2002-03-11
Granted: 2013-05-27
Abstract: The invention relates to the field of connectors for connecting a container with a fluid preparation device for preparing a fluid, in particular a container with a concentrate for the preparation of dialysis fluid. In order to simplify the handling during both the manufacturing process of such containers and the connection of such containers to the fluid preparation devices, the invention proposes a design of a connector (1) for connecting a first and second fluid line of the container with a third and fourth fluid line of the fluid preparation device with two lateraly spaced-apart mounting means (2, 4) which each incorporate one of two orifices (3, 5) terminating the first and second fluid lines. The invention also concerns a corresponding container and fluid preparation device.
Patent DK-2314654-T3 (DK)
Title: COMPOSITIONS CONTAINING fluorine substituted olefins
Inventor: PHAM HANG T
IPC: C09K5/04
Filed: 2003-10-27
Granted: 2016-11-28
Abstract: A method of sterilizing an article comprises contacting said article with a composition comprising at least one fluoroalkene of Formula I:  
 XCF z R 3-z (I)  
where X is a C 2  or a C 3  unsaturated, substituted or unsubstituted, alkyl radical, R is independently Cl, F, Br, I or H, and z is 1 to 3.
Patent DK-2389937-T3 (DK)
Inventor: NAKAGAWA MASAYA
IPC: A61P25/28
Filed: 2003-04-03
Granted: 2018-11-12
Abstract: Use of a following ingredients in combination for use in the treatment or prevention of dysfunction of cerebral acetylcholine neurons in the sequela of cerebrovascular dementia, senile dementia, Alzheimer's disease, ischemic cerebral lesion and cerebral apoplexy or the memory impairment caused by selective neuronal death: 
Ingredient (A): 
an alkyl ether derivative represented by the following formula:   
wherein either 
(R 1  represents a benzothienyl group; 
R 2  represents a hydrogen atom; 
R 3  and R 4 , each represents a C 1-6 alkyl group which is optionally substituted with a hydroxyl group; 
R 3  and R 4 , taken conjointly with the nitrogen atom to which R 3  and R 4  are linked, form an azetidine ring which is optionally substituted with a hydroxyl group; 
m represents an integer of 1; and 
n represents an integer of 3); 
or a salt thereof,  
Ingredient (B) : 
Tacrine or 
Donepezil 
for the manufacture of a pharmaceutical composition.
Patent DK-0410367-T3 (DK)
Inventor: DEREGIBUS ALFIO
IPC: B29C31/00
Filed: 1990-07-24
Granted: 1993-04-19
Abstract: The present invention relates to a machine for the production of vulcanized rubber tubing. The machine comprises a pair of opposite heads (2,3) provided with mandrels (4,5), which rotate at least one tubular core (6,7) supported by first roller-fitted resting elements which are fixed on a supporting frame (11). The line of the rollers, and therefore the tubular core, is flanked by an openable thermally insulated box-like container (19) adapted to contain the core itself, wrapped by the tubing to be vulcanized and unloaded by transfer means coupled to the frame (11). The heads of the box-like container (19) have electric terminals for supplying power to the core (6,7) and heating it by means of the Joule effect. Removal means move the core from the container onto second retractable roller-fitted resting elements which are articulated to the frame for extracting the core from the vulcanized tubing by injecting air.
Patent DK-0414170-T3 (DK)
Inventor: HOFFMANN HERMANN DR
IPC: B01D53/14
Filed: 1990-08-18
Granted: 1994-06-13
Abstract: Aqueous aldehyde solutions for trapping hydrogen sulfide comprising 5 to 50% by weight of an aldehyde and 1 to 5% by weight, relative to the aldehyde solution of a formulation comprising 10 to 80% by weight of an ester of oxalkylated alkylalkylenediamines, which may be quaternized and 20 to 90% by weight of water or of a C1-C4-alcohol.
Patent DK-0388019-T3 (DK)
Inventor: BLIZZARD TIMOTHY A
IPC: A61K31/365
Filed: 1990-02-15
Granted: 1994-05-24
Abstract: There are disclosed avermectin aglycone derivatives which incorporate a ketal at position 13. The synthetic ketal analogs are derived from the corresponding ketones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.
Patent DK-0395293-T3 (DK)
Inventor: PARKE IAN
IPC: G06T7/20
Filed: 1990-04-18
Granted: 1999-04-06
Abstract: A motion vector for motion-compensated prediction in an inter-frame differential video coder is derived by comparing each block in a row of a current frame with the corresponding region, and positionally shifted regions, of a previous frame. The blocks are processed row by row, and scanned in a vertical column-by-column scan with each of the shifted regions. Two or more rows may be processed at a time. For a +/-7 pixel search, two or four comparison processors are provided, one (or one pair) processing odd-numbered blocks and the other (or other pair) processing even-numbered blocks. For a +/-15 pixel search, four or eight processors are provided. The vertical scan is provided using a serial FIFO store including eight 8 tap SIPO sections.
Patent DK-0407280-T3 (DK)
Inventor: LE MER JOSEPH
IPC: F16L37/14
Filed: 1990-06-29
Granted: 1993-02-01
Abstract: To connect two pipes together, a female end-piece (1) is fitted thereon comprising an annular seal housed in an annular cup (2) and a pin (6) guided in transverse slides (9) and, respectively, a male end-piece ending in a collar and adapted to crush the seal axially. The pin comprises two arms (8) whose end sections (82) allow the collar to pass axially and whose base sections (81) on the contrary serve for clamping the collar axially against the seal, these base sections ending in ramps (R) facilitating the beginning of cooperation between the arms and collar. Hooks (12) limit the outgoing travel of the pin.
Patent DK-0432094-T3 (DK)
Inventor: GALLANDRE JEAN-PIERRE
IPC: B21D55/00
Filed: 1990-11-22
Granted: 1994-03-28
Abstract: In a bending press in which a slider (15) is displaceable by means of hydraulic drive devices comprising jacks (1, 1') disposed on the sides of the slider and coupled with means of detecting the position and speed of the slider, the displacement of the slider is measured in a given time or over a given distance starting from a stop position reached after a movement interrupt command, in order to determine possible abnormal leakages in the hydraulic devices. Furthermore, there is an independent comparison between the stop time or distance of each of the jacks with reference values in order to detect symmetry faults in the drive devices.
Patent DK-0502032-T3 (DK)
Inventor: RING STEPHEN GORDON
IPC: A61K9/52
Filed: 1990-11-22
Granted: 1994-05-09
Abstract: PCT No. PCT/GB90/01803 Sec. 371 Date Jul. 7, 1992 Sec. 102(e) Date Jul. 7, 1992 PCT Filed Nov. 22, 1990 PCT Pub. No. WO91/07949 PCT Pub. Date Jun. 13, 1991.Delayed release compositions comprising an active compound and amorphous amylose and having an outer coating comprising a film forming cellulose or acrylic polymer material, for example glassy amylose are of particular value for the selective release of medicaments and diagnostic agents into the colon.
Patent DK-0460344-T3 (DK)
Inventor: VOELPEL DIETWART
IPC: A61L2/26
Filed: 1991-01-02
Granted: 1995-07-31
Abstract: Device for cleaning and sterilising objects, in particular pharmaceutical fasteners, having an autoclave chamber (16) and a cleaning device (36) which contains a cleaning drum (38) which is rotatably mounted on a frame (40). The frame runs on rollers (50) and can be moved into the autoclave chamber and out of it. The cleaning drum has a hollow shaft (40) which is provided inside the drum with spray nozzles and is axially flush with a hollow drive shaft which is inserted tightly and rotatably into the autoclave chamber through a side wall of said chamber. The hollow drum shaft (40) and the hollow drive shaft can be coupled by a coupling device. In a preferred embodiment, the frame (48) can be released from the drum inserted into the autoclave chamber and removed from the autoclave chamber so that during the cleaning process it is not located in the autoclave chamber and does not constitute an additional source of contamination. <IMAGE>
Patent DK-0463524-T3 (DK)
Inventor: MAGERS THOMAS A
IPC: C12Q1/00
Filed: 1991-06-15
Granted: 1996-07-22
Abstract: A composition, test device and method of determining the presence or concentration of ketone bodies, and specifically D- beta -hydroxybutyrate, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with D- beta -hydroxybutyrate to produce a detectable or measurable response. In addition, a new and improved indicator reagent composition, comprising a) an indicator dye that is responsive to thiols, such as a substituted isobenzothiazolone, Ellman's reagent or a derivative of Ellman's reagent; b) D- beta -hydroxybutyrate dehydrogenase; c) lipoamide dehydrogenase; d) D,L-lipoamide; and e) nicotinamide adenine dinucleotide, is incorporated into the carrier matrix to provide an accurate and sensitive assay of a test sample for D- beta -hydroxybutyrate (DHBA) in particular, and for ketone bodies in general. The improved method and composition are especially useful in the assay of whole blood, blood serum, blood plasma and urine for ketone bodies.
Patent DK-0521310-T3 (DK)
Inventor: WATANABE DAIICHI
IPC: A61P9/04
Filed: 1992-06-04
Granted: 1999-09-13
Abstract: The present invention relates to a pharmaceutical solid dispersion tablet comprising a solid dispersion material (a) which comprises a substantially water-insoluble 1,4-dihydropyridine derivative as pharmaceutical active agent represented by the general formula [I]: <CHEM> wherein Ar is a substituted aryl or benzofurazanyl group, R<1> is a substituted or unsubstituted alkyl group, R<2> is a substituted or unsubstituted alkyl or alkenyl group or a substituted piperidyl group, R<3> and R<4> each independently represent a substituted or unsubstituted alkyl group, and the substituent R<1>OCO- at the 5-position may be replaced by a dialkylphosphonoate or alkylene dioxyphosphoryl group, or a pharmaceutically acceptable acid addition salt thereof and hydroxypropyl cellulose; and a solid dispersion material (b) which comprises said 1,4-dihydropyridine derivative or its pharmaceutically acceptable acid addition salt and hydroxypropyl methyl cellulose phthalate. The present invention also relates to a process for preparing the above solid dispersion tablets.
Patent DK-0509596-T3 (DK)
Inventor: VAN DROGENBROEK JOHANNES NICOL
IPC: E06B1/08
Filed: 1992-04-09
Granted: 1998-01-19
Abstract: It comprises a wooden construction enclosing the wall with a part (1) extending over the thickness of said wall, and at least one part (2,3) connecting thereto and resting against the wall. The part extending over the thickness of the wall comprises a wood material which is not solid, such as a board material, and in particular a fibreboard material. The construction can produce a finished wall. <IMAGE>
Patent DK-0551796-T3 (DK)
Inventor: LO CHIEN-CHO
IPC: A01P13/00
Filed: 1992-12-22
Granted: 1998-03-23
Abstract: This invention relates to a process for encapsulation and particularly for the preparation of microcapsules having a capsule wall of a solid polymeric substance enclosing a water-immiscible material, which process comprises preparing a solution of a first reactive component required to form the capsule wall in the water-immiscible material, then dispersing the mixture in an aqueous medium containing a surfactant which is a salt of a partial ester of a styrene-maleic anhydride copolymer, to form an oil-in-water emulsion, and subsequently adding a second reactive component required to form the capsule wall which is complementary to the first one and reacts with it under the mixing conditions, whereby a solid polymeric wall is formed about the dispersed water-immiscible material. The resulting stable aqueous suspension of microcapsules can either be used directly or after dilution with water, or the microcapsules can be separated from the aqueous phase.
Patent DK-0578752-T3 (DK)
Inventor: SHENNIB ADNAN A
IPC: H04R1/00
Filed: 1992-04-01
Granted: 1997-10-06
Abstract: An inconspicuous hearing system is described that uses a coil to electromagnetically couple with, and therefore drive, a permanent magnet attached to the tympanic membrane or ossicular chain. This hearing system enables hearing impaired individuals, as well as persons with normal hearing, to selectively receive sound signals in a wide variety of hearing environments while avoiding socially or aesthetically unacceptable stigmas associated with visible wires, headphones, earpieces, etc.
Patent DK-0594724-T3 (DK)
Inventor: RENSING CORNELIS WILLEM
IPC: B01J/
Filed: 1992-07-11
Granted: 1996-09-02
Abstract: An improved process for the phytoprotection of plant seeds, wherein there is simultaneously applied to the seeds, on the one hand, at least one first liquid composition containing at least one phytoprotection product, and on the other hand, a foam formed from a second composition, containing at least one nonphytotoxic foaming agent.
Patent DK-0588539-T3 (DK)
Inventor: SILVER DAVID ISAAC
IPC: A61K47/08
Filed: 1993-09-03
Granted: 1997-03-10
Abstract: 1. A solid state pharmaceutical composition which comprises at least ingredients (a), (b) and (c) of the following ingredients (a), (b), (c) and (d), namely:   (a) at least one active component selected from pharmaceutically active derivatives of vitamin D2 and vitamin D3;   (b) at least one pharmaceutically acceptable antioxidant; (c) at least one pharmaceutically acceptable polyoxyalkyl stabilizer;   (d) at least one solid pharmaceutical excipient or carrier in an amount sufficient to impart the characteristics of a solid to the composition.
Patent DK-0604389-T3 (DK)
Inventor: DUEHRKOOP JENS DIPL-ING
IPC: F16D66/00
Filed: 1993-12-17
Granted: 1998-12-07
Abstract: In a device for detecting unacceptably heated components or spots on moving objects, in particular on moving rail vehicles such as for example bearings, brakes and/or wheel flanges, having at least one infrared radiation detector (7) and optical devices for imaging the measurement point on the radiation detector (7), a separate lens (1,2) is directed onto each measurement point, which lens (1,2) focuses the image of the measurement point on different points (4,5) of an image correction system (3), a sensing device (9) which periodically detects the measurement rays and focuses the measurement rays onto the detector (7) which is common to all the measurement points being arranged between the image correction system (3) and the detector (7). <IMAGE>
Patent DK-0623112-T3 (DK)
Inventor: HAMANAKA ERNEST S
IPC: A61K31/495
Filed: 1992-12-21
Granted: 1999-08-30
Abstract: Compounds of formula (I) wherein each m is independently selected from 0 to 4; R<2> is selected from hydrogen and (C1-C6) alkyl; each R<3> and R<4> is independently selected from halogen, (C1-C6) alkyl optionally substituted with one or more halogen atoms, (C1-C6) alkoxy optionally substituted with one or more halogen atoms, (C1-C6) alkylthio optionally substituted with one or more halogen atoms; nitro, carboxyl optionally esterified with a (C1-C6) alkyl group; hydroxyl, (C1-C4) acyloxy and (C1-C3) acyl; X is sulfur or oxygen; and Q is a group of formula (XIV), (XV) or (XVI) wherein m is as defined above; n is 0 or 1. Each 1 is independently selected from 0 to 3; each R<6> and R<7> is defined in the description; B, D, E and G are selected from the group consisting of nitrogen and carbon, with the proviso that one or more of B, D and E is nitrogen, and with the proviso that when G is nitrogen, the group XVI is attached to the nitrogen of formula (I) at the 4 or 5 position of the pyrimidine ring (designated by a and b) wherein any of said nitrogens may be oxidized, or the pharmaceutically acceptable salts thereof, and intermediates having formula (IV) used in the synthesis of such compounds. The compounds of formula (I) are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
Patent DK-0651821-T3 (DK)
Inventor: MARGOLIN ALEXEY L
IPC: C12P13/00
Filed: 1993-06-15
Granted: 1997-09-01
Abstract: The present invention relates to the enzymatic resolution of a racemic mixture of stereospecific, pharmaceutically useful in vivo inhibitors of  gamma -aminobutyric acid transaminase (GABA-T), specifically  gamma -ethynyl GABA,  gamma -vinyl GABA and  gamma -allenyl GABA using penicillin acylase (PA).
Patent DK-0623619-T3 (DK)
Inventor: DELAMANO GARCIA JOSE
IPC: C07D209/00
Filed: 1993-09-22
Granted: 1999-09-20
Abstract: The areno(e)indols have the formula (I). The methods comprises: (a) reacting (VI) with an aldehyde Ar''-CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acyle chloride CICOR, to produce (IX); (d) subjecting to a photochemical cyclization (IX) to produce (I). In said formulas Ar is phenyl or substituted phenyl; Ar' is a radical (i) or )ii); R is an acyle group, Ar'' is a phenyl, pyrolyl, furanyl or thiophenyl group substituted up to three times by any of the radicals R, R<1>, R<2>, or R<3>. The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
Patent DK-0611832-T3 (DK)
Inventor: KUGLER WERNER
IPC: F01M11/00
Filed: 1994-02-09
Granted: 1996-12-09
Abstract: The present invention relates to a process for producing castings, in which the casting mass is cast, in the liquid state, in a mould, cooled down and then removed from the mould, whereupon a local heat treatment is carried out at such temperatures and over such a period of time that regions of different hardness are produced. This local heat treatment is carried out in particular at temperatures above twice the overageing temperature. The invention furthermore relates to an oil trough with at least one flange and a base region, which trough is produced by casting, in particular by pressure die casting, and is distinguished by hardness of HB 85 - 110 and a ductility of 0.5 - 2.5 % in the flange region and a hardness of HB 55 - 80 and a ductility above 4 % in the base region. <IMAGE>
Patent DK-0639523-T3 (DK)
Inventor: KAFEMAN HENRY DAVID
IPC: B65H45/18
Filed: 1994-08-04
Granted: 1997-03-17
Abstract: Chopper action folding apparatus for high speed printing or similar processing plant is shown diagrammatically in Figure 3. A conveyor (10) feeds signatures (12) towards a headstop (20). A vertical chopper blade (24) extending along the centre of the feed path is oscillated to initiate longitudinal folding of each signature as it is pressed downwards into a nip between longitudinal folding rolls (22) below the feed path which complete the folding process by drawing the signature downward. Brush or other braking means (26) slow or stop the approaching signatures before or as they reach the headstop so that they are folded without damage, the braking pressure being automatically regulated by control means (30) including infra-red or other position sensing means (32) which detects the relative positions of the headstock and approaching leading edge (14) of each signature for optimum operation. <IMAGE>
Patent DK-0675711-T3 (DK)
Inventor: DEARN ALAN ROY
IPC: A61P33/00
Filed: 1993-12-23
Granted: 1999-05-03
Abstract: The invention relates to a process for the production of microfluidized particles of atovaquone having improved bioavailability.
Patent DK-0699690-T3 (DK)
Inventor: MEYER ARMIN
IPC: C08F20/12
Filed: 1995-08-28
Granted: 1999-11-22
Abstract: Casting resin formulations with a microdomain structure in the hardened state comprise mixt. of (meth)acrylate monomers, opt. poly(meth)acrylate prepolymers, opt. monomeric crosslinkers, radically polymerisable carboxylic acids, release agents, polymerisation initiators, opt. dyes, pigments and/or fillers, and also 2-15 wt.% of an ester of formula X-(-O-C(=O)-R3)n (II) as opacifier. In (II), R3 = 10-30C alkyl or aralkyl; n = 1-6; X = 8-30C alkyl or aralkyl if n = 1, or 1-30C alkylene or aralkylene if n = more than 1; n may not be greater than the number of C atoms in X.
Patent DK-0728034-T3 (DK)
Inventor: VAN RIJN CORNELIS JOHANNES MAR
IPC: B01D69/02
Filed: 1994-11-14
Granted: 2007-11-19
Abstract: PCT No. PCT/EP94/03783 Sec. 371 Date May 10, 1996 Sec. 102(e) Date May 10, 1996 PCT Filed Nov. 14, 1994 PCT Pub. No. WO95/13860 PCT Pub. Date May 26, 1995A membrane filter comprises a membrane provided with pores with a pore size between 5 nm and 50  mu m. The membrane may easily and reliably be processed with use of silicon micromachining through depositing a relatively thin membrane layer on a support, by use of a suitable vapour deposition or spincoating technique, after which perforations are made in the thin membrane layer, for example by etching with aid of photo-lithography or an imprint technique. Such a membrane is very well applicable for the separation of biological cells. A membrane with a thickness smaller than the diameter of the perforations is in particular suited for the separation of vulnerable cells and may be used as a leucocyte filter or as a blood plasma separator of blood concentrates. A microfiltration membrane according to the invention may very well be applied as a support for the deposition of a separation layer for ultrafiltration, gas separation or catalysis.
Patent DK-0785776-T3 (DK)
Inventor: COOMBES ALLAN GERALD ARTHUR
IPC: A61K9/38
Filed: 1995-10-10
Granted: 2000-09-18
Abstract: A process is described for preparing microspheres, films and coatings from protein or modified protein in which the protein product is stabilized by carrying out the preparation in the presence of an aqueous solution of at least one alpha-hydroxy acid. Preferred alpha-hydroxy acids are glycolic acid, lactic acid, alpha-hydroxybutyric acid or a mixture of two or more thereof. The microspheres, films and coatings so produced have improved stability in aqueous solution.
Patent DK-0799949-T3 (DK)
Inventor: BLANKE-BOHNE J PROF DR
IPC: E04F13/08
Filed: 1996-11-23
Granted: 2002-02-04
Abstract: The natural stone element consists of at least one thin slab of natural stone (11) and a carrying slab connected to its large surface. The carrying slab consists of a glass sheet (12) bonded to the natural stone slab on a large surface of it by a transparent glass sheet. The natural stone slab may have a visible surface rod which at least one protective glass sheet (12) is fitted. A similar protective glass sheet may also be fitted to the non-visible side of the slab. These protective sheets may consists of several layers, bonded both to each other and to the natural stone by transparent resin.