baber/WOPTO huggingface dataset:
Patent CA-2159610-C (CA)
Inventor: KOZAK ALEXANDER
IPC: C12P17/18
Filed: 1994-03-30
Granted: 2008-05-20
Abstract: The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to intracellular enzyme activity. The prodrug may be used in a technique for treating a condition or disease in a human related to supranormal intracellular enzyme (e.g. phospholipase and/or esterase) activity, whereby on administering it to a human having such condition or disease, the bond is broken in response to such activity, and the pharmacologically active compound accumulates selectively within cells having such supranormal intracellular enzyme activity. Exemplary conjugates are esters of the carboxylic function in the formula, with e.g.  heptanoyl-sn-3--glycerophosphoryl-choline or octanoyl-sn-3-glycerophosphoryl-choline.
Patent CA-2164275-C (CA)
Inventor: MYSLINSKI PIOTR
IPC: H01S3/067
Filed: 1995-12-01
Granted: 2001-10-30
Abstract: By using a pumped erbium doped fibre (EDP) cascaded with a non-saturable absorbing fibre (NSAF), an amplifier is provided with a desired flat uniform output response for a input signals with different at a plurality of wavelengths. Furthermore, from a commercial standpoint, the amplifier is relatively inexpensive and simple to fabricate, being compatible with standard telecommunication fibre. With this particular invention, a previously recognized undesired characteristic of NSAF, its poor amplification qualities, are now being used to an advantage.
Patent CA-2164591-C (CA)
Title: Process for recycling polyesters
Inventor: SCHWARTZ JOHN A JR
IPC: C07C63/26
Filed: 1995-04-27
Granted: 2000-02-15
Abstract: A process for recycling polyester contained in waste materials is provided. The polyester is converted into a corresponding acid salt of a polybasic organic acid and a polyol. The process steps generally include first combining materials containing polyester with an alkaline composition to form a mixture. The mixture is heated, causing the polyester to convert to the acid salt and polyol. The polyol is evaporated and separated from the acid salt.
Patent CA-2165334-C (CA)
Title: Systeme de communication sans fil haute frequence monte sur une seule puce ultramince de silicium sur saphir
Inventor: REEDY RONALD E
IPC: H01L21/762
Filed: 1994-06-10
Granted: 2001-03-20
Abstract: L'invention concerne un système de communications sans fil à haute fréquence sur une microplaquette ultramince de silicium sur saphir. Ce système comporte des circuits analogiques, numériques (logique et mémoire) et des circuits pour hautes fréquences radio sur une seule microplaquette ultramince de silicium sur saphir. Les dispositifs sont fabriqués en utilisant des techniques de fabrication des circuits CMOS sur silicium. Parmi les avantages, on peut citer une architecture de microplaquette unique, un rendement amélioré à haute fréquence, une consommation faible en énergie et des coûts de fabrication bas.
Patent CA-2166179-C (CA)
Title: Use of a tnf-alpha antagonist in a cosmetic, pharmaceutical or skincare composition and composition thus obtained
Inventor: DE LACHARRIERE OLIVIER
IPC: A61K33/40
Filed: 1995-12-27
Granted: 2007-06-19
Abstract: The invention relates to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist in a cosmetic, pharmaceutical or dermatological composition for treating sensitive skins. It relates especially to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist for preventing and/or combating skin irritations and/or sores and/or erythema and/or dysaesthetic sensations and/or sensations of inflammation and/or pruritus and/or prickling and/or tingling and/or discomfort and/or tightness of the skin and/or mucosae. It also relates to a composition containing a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist which limits or eliminates the irritant side-effects of certain products, and in particular of certain cosmetic, dermatological or pharmaceutical active agents.
Patent CA-2170573-C (CA)
Inventor: LANGEMAN GARY D
IPC: B05B15/04
Filed: 1996-02-28
Granted: 1999-11-09
Abstract: The present invention provides an adhesive filament-bearing adhesive tape comprising an adhesive substrate adapted to be releasably adhered to a surface to be coated and a filament releasably adhered to an edge of that substrate that is useful in trimming a coating applied to a surface. The invention further provides a method of trimming a coating applied to a surface comprising applying to the surface to be coated a masking material to define the area to be coated and a filament of material of sufficient tensile strength to cut the coating material; applying coating material to the surface; allowing the coating material to dry or cure until it obtains sufficient strength to hold a cut edge; and drawing the filament through the coating to cut the coating. Finally, the present invention provides an apparatus for making a filament-bearing adhesive tape comprising means for folding an adhesive substrate along a predefined line; means for applying a filament to the interior of the fold so formed; and means for closing said fold to retain said filament at the edge of the filament bearing tape.
Patent CA-2170846-C (CA)
Title: Process for preparing 3-chloropropionic acid
IPC: C07C51/363
Filed: 1996-03-01
Granted: 1999-02-16
Abstract: Prodn. of 3-chloropropionic acid (I) comprises simultaneously adding HCl gas and acrylic acid to a mixt. of 70-100 wt.% (I) and 0-30 wt.% water or aq. HCl, and opt. continuing to add HCl gas.
Patent CA-2173785-C (CA)
Inventor: MIYASHITA TOSHIKAZU
IPC: H04L27/00
Filed: 1996-04-10
Granted: 1999-04-06
Abstract: An automatic frequency control circuit comprises an quadrature demodulation unit for creating an in-phase signal and an antiphase signal by quadrature-demodulating a Gaussian Minimum Shiftkeying signal and supplying an electric field strength signal exhibiting an electric field strength of the Gaussian Minimum Shiftkeying signal as well as the created in-phase and antiphase signals; a quality judging unit for judging the quality of the Gaussian Minimum Shiftkeying signal and creating an automatic frequency-controlling data indicating a compensation amount in accordance with the obtained quality signal; a converter for converting into digital signals the in-phase signal, antiphase signal and electric field strength signal supplied from the quadrature demodulation unit and converting the automatic frequency-controlling data into an analog signal; a temperature compensated crystal oscillation circuit for compensating the frequency of the GMSK signal on the basis of the compensation amount indicated by the automatic frequency-controlling data converted into an analog signal by the converter.
Patent CA-2174528-C (CA)
Title: Appareil a eclairage par l'arriere employant un ensemble de microprismes
Inventor: BEESON KARL WAYNE
IPC: G02F1/13357
Filed: 1994-11-02
Granted: 2006-07-11
Abstract: Appareil amélioré à éclairage par l'arrière comprenant un guide d'ondes (6) sous forme de plaque qui accepte des rayons de lumière produits par une source de lumière (4) et transmet lesdits rayons de lumière par la réflexion interne totale. Ledit guide d'ondes porte fixés sur une de ses faces un ensemble de microprismes (28), chaque microprisme (28) ayant une surface (30) d'entrée de lumière parallèle à une surface de sortie (32) de lumière et au moins une paroi latérale (33) inclinée à un certain angle par rapport à la direction perpendiculaire à la surface du guide d'ondes (6) de telle manière que des rayons de lumière s'échappent dudit guide d'ondes (6), soient réfléchis par la paroi latérale inclinée (33) et émergent du microprisme (28) en tant que source de lumière sensiblement perpendiculaire à la surface (32) de sortie de la lumière. Un ensemble de microlentilles peut être placé de façon à accepter la lumière sortie des microprismes si bien que la lumière sortant desdites microlentilles est sensiblement plus perpendiculaire. Ledit appareil à éclairage par l'arrière est utilisé avantageusement en tant que dispositif à éclairage par l'arrière pour des panneaux d'affichage électroniques plats.
Patent CA-2180445-C (CA)
Inventor: NICOLAOU KYRIAKOS C
IPC: C07D407/12
Filed: 1995-01-10
Granted: 2005-11-22
Abstract: Cyclic chemical switching method is employed for solubilizing and desolubilizing taxo-diterpenoids with respect to aqueous solvents. 2-Halogenated onium salts of aza-arenes (I and II) (see figure I  and II) wherein: R0 is a halogen selected from the group consisting of Cl, Br, F, and I; Z1 and Z2 are each selected from the group consisting of C and N; Z3 is selected from the group consisting of S and O; R1 is selected from the group consisting of C1-C6 alkyl, allyl, arenxyl, propargyl, and fused aryl; R2 and R6 are each selected from the group consisting of H, C1-C6 alkyl, allyl, arenxyl, propargyl, and fused aryl; if Z1 is C, then R3 is selected from the group consisting of H, C1-C6 alkyl, allyl, arenxyl, propargyl, C1-C6 O-alkyl, OH, halogen, and fused aryl; if Z1 is N, then R3 is absent; R4 and R8 are each selected from the group consisting of H, C1-C6 alkyl, allyl, arenxyl, propargyl, C1-C6 O-alkyl, OH, halogen, and fused aryl; if Z2 is C, then R5 is selected from the group consisting of H, C1-C6 alkyl, allyl, arenxyl, propargyl, C1-C6 O-alkyl, OH, halogen, and fused aryl; if Z2 is N, then R5 is absent, and S- is a counter ion;   are employed to derivatize taxo-diterpenoids so as to alter their solubility in aqueous solvents. The onium salt of aza-arene includes a delocalized charge which imparts polarity and aqueous solubility to taxo-diterpenoid derivatives. Solubilization is achieved in a one step derivatization with the onium salt of 2-halogenated aza-arenes. Desolubilization is achieved by contacting onium salts of taxo-diterpenoid-C n,2-O-aza-arenes with serum protein to displace the 2-O-aza-arene and form a soluble protein:taxo-diterpenoid intermediate. This protein:taxo-diterpenoid intermediate then dissociates over time to provide a bioactive taxo-diterpenoid. Preferred taxo-diterpenoids include taxol, C-2 substituted taxol, and Taxotere .TM.. These same onium salts of taxo-diterpenoid-C n, 2-O-aza-arenes are employed as water soluble prodrugs. For example, taxol-2'-methylpyridinium tosylate (MPT) is characterized by an elevated aqueous solubility, rapid activation by serum protein, good stability in most other aqueous solutions, formation of a protein:taxol intermediate and good retention within the circulatory system. The toxicity of the activated form is comparable or greater than underivatized taxol. Furthermore, taxol-2'-MPT can be synthesized by a simple one step reaction between taxol and 2-fluoro-1-MPT. The invention is applicable to taxol and taxol mimetics having hydroxyls that are reactive with onium salts of 2-halogenated-aza-arenes. For example, taxol and Taxotere each have reactive hydroxyls at the 2' and 7 positions. The invention is also applicable to a wide array of 2-halogenated-aza-arenes.
Patent CA-2184678-C (CA)
Inventor: OHSAKI TAKASHI
IPC: H01M4/485
Filed: 1996-09-03
Granted: 2009-03-17
Abstract: The present invention relates to a non-aqueous electrolyte secondary battery. The graphitized vapor-grown carbon fibers used as an anode in the present invention have a specific surface area of at most 5 m2/g and an average aspect ratio of 2-30. The non-aqueous electrolyte secondary battery comprises an anode comprising a cathode comprising a lithium-containing complex oxide, an anode comprising the graphitized vapor-grown carbon fibers, and an electrolyte comprising a lithium salt and a solvent. The present invention provides a non-aqueous electrolyte secondary battery having a high capacity maintained over a broad temperature range, good cycle characteristics, a high safety and an improved load characteristics.
Patent CA-2188104-C (CA)
Title: Copy protection by inserting a phase-shifted color burst signal into the burst interval of an analog color video signal
Inventor: SATO HIDEO
IPC: H04N5/91
Filed: 1996-10-17
Granted: 2004-04-20
Abstract: An analog color video signal is prevented from being satisfactorily copied by inserting a phase-shifted color burst signal of predetermined duration into a predetermined location of the usual burst interval of that analog color video signal. The predetermined location may precede the normal color burst signal, or it may follow the normal color burst signal or it may be located in the middle of the burst interval.
Patent CA-2188235-C (CA)
Inventor: HATKE WILFRIED
IPC: C08L37/00
Filed: 1996-10-18
Granted: 2007-03-20
Abstract: The invention relates to a one- or two-sided-metalized, single- or multilayer polyolefin film in which at least one outermost layer of the unmetalized polyolefin film essentially consists of a cycloolefin polymer which has not been subjected to a process for increasing the surface tension before the metalization.
Patent CA-2189862-C (CA)
Inventor: WALLACE WILLIAM G
IPC: C10M169/06
Filed: 1995-04-19
Granted: 2004-06-29
Abstract: Graisse lubrifiante se caractérisant par des propriétés améliorées de pénétration, de stabilité au cisaillement et un meilleur point de goutte. Cette graisse lubrifiante comprend une huile de base, un adjuvant, un épaissisant contenant de l'urée et un épaississant au savon de lithium.
Patent CA-2190764-C (CA)
Inventor: ARBOGAST ROBERT E
IPC: A61F2/00
Filed: 1996-03-20
Granted: 2007-11-20
Abstract: The invention relates to a polymeric gel and various articles of manufacture such as a cushion liner, a cushion locking liner, an open-ended cushion knee or elbow sleeve, and a cushion flat sheet, all useful for increasing the comfort of the wearer. Also described are sleeve members and liners for enclosing an amputation stump. The polymeric gel composition preferably comprises a block copolymer and mineral oil.
Patent CA-2191795-C (CA)
Title: Antisense oligonucleotide modulation of raf gene expression
Inventor: MONIA BRETT P
IPC: A61K31/7088
Filed: 1995-05-31
Granted: 2003-06-10
Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf.  The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
Patent CA-2191812-C (CA)
Inventor: LEAVITT FREDERICK WELLS
IPC: B01J20/18
Filed: 1996-12-02
Granted: 1999-06-22
Abstract: Zeolites containing mixed cations are conveniently prepared by saturating the zeolites with the less strongly held cation, and then injecting the more strongly held cations in a pulse in a recirculating brine solution containing the less strongly held cation.  The more strongly held cation is thus exchanged with the less readily held cation on the surface of the zeolite, after which the particles are allowed to equilibrate, with the distribution of the cations within the particles approaching an equilibrium value.
Patent CA-2192394-C (CA)
Inventor: TAMAI SHOJI
IPC: C08L79/08
Filed: 1990-10-23
Granted: 2000-08-15
Abstract: Disclosed is a resin forming composition comprising ( i ) an aromatic diamine compound represented by the formula (I)          (I) (wherein R is H or CH3) and (ii) a bismaleimide compound represented by the formula (IV)          (IV) (wherein R is H or CH3) . A resin obtained from the composition may be used as a coating film, adhesive layer or molded article.
Patent CA-2194659-C (CA)
Inventor: MAGILL DAVID THOMAS
IPC: H04J13/12
Filed: 1995-07-13
Granted: 2008-10-07
Abstract: The present invention is directed to the use of bandwidth efficient OCDMA in a multipath environment. The high rate PN code greatly attenuates multipath components that are delayed enough to have significant impact on the degree of orthogonality that may be achieved. By offsetting the carriers by the RW chipping rate and using precise network timing to align all accesses to a small fraction of a high rate PN chip duration, it is possible to fully utilize the available bandwidth. The procedure for achieving this time base alignment has been previously disclosed in U.S. patent application Serial No. 980,957
Patent CA-2198655-C (CA)
Title: Mass scanning method using an ion trap mass spectrometer
Inventor: WELLS GREGORY J
IPC: H01J49/04
Filed: 1997-02-27
Granted: 2002-02-12
Abstract: An improved method of using an ion trap mass spectrometer is disclosed. According to the method an asymmetrical trapping field is applied to the trap. Preferably, the asymmetrical trapping field comprises a quadrupole field and a dipole field having the same frequency. In addition, higher order trapping field components, such as hexapole or octopole fields, may also be included, and the electrodes of the ion trap can be shaped to introduce such higher order field components. The effect of the asymmetrical trapping field of the present invention is to cause the center of the trapping field to be displaced from the mechanical center of the ion trap. A supplemental quadrupole field is then applied to the ion trap, the center of the supplemental quadrupole field being located at the mechanical center of the trap, i.e., it is displaced from the center of the trapping field. The supplement quadrupole field and the trapping field may be viewed as forming one combined field which acts upon the ions in the trap. The combined field is then scanned to cause ions of differing masses to be resonantly ejected from the ion trap in sequential mass order. Preferably, the combined field is scanned by scanning the voltage of the trapping field. Preferably, the supplemental field is set to have a frequency which is two-thirds of the trapping field frequency and is phase locked with the trapping field frequency.
Patent CA-2200640-C (CA)
Title: Film for multiple bag
Inventor: FUKUSHIMA YUJI
IPC: B65D30/08
Filed: 1997-03-21
Granted: 2001-01-23
Abstract: A film for a multiple bag which film is a multiple film comprising at least two sheets of film put one on another and having scattered along its both-side edge portions spot-fused portions by which the at least two sheets of film is partially united.
Patent CA-2201324-C (CA)
Inventor: VAN DEN ENGH GER
IPC: G01N15/14
Filed: 1995-10-13
Granted: 2006-12-12
Abstract: A droplet forming flow cytometer system (1) allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal (10) within the nozzle volume (3) and directly coupled to the sheath fluid. The nozzle container (27) continuously converges so as to amplify unidirectional oscillations (11) which are transmitted as pressure waves through the nozzle volume (3) to the nozzle exit so as to form droplets from the fluid jet. The oscillator is directionally isolated so as to avoid moving the entire nozzle container so as to create only pressure waves within the sheath fluid. A variation in substance concentration is achieved through a movable substance introduction port (9) which is positioned within a convergence zone (32) to vary the relative concentration of substance to sheath fluid while still maintaining optimal laminar flow conditions. This variation may be automatically controlled through a sensor and controller configuration.    A replaceable tip design is also provided whereby the ceramic nozzle tip is positioned within an edge insert (29) in the nozzle body (24) so as to smoothly transition from nozzle body (24) to nozzle tip (25). The nozzle tip is sealed against its outer surface to the nozzle body so it may be removable for cleaning or replacement.
Patent CA-2203131-C (CA)
Title: Method and apparatus for secure identification of a mobile user in a communication network
Inventor: TSUDIK GENE
IPC: G06F21/34
Filed: 1994-10-27
Granted: 2004-03-30
Abstract: Communication between mobile users of and in a computer network is subject to a variety of security issues; user identification and user tracking are two particularly important ones. This invention provides a method and an apparatus for securely identifying a mobile user while avoiding trackability of his/her movements, i.e. it provides a way for a secure user identification in secrecy. The gist is to encrypt the user's identifier, and/or his/her password, and a synchronization indication, preferably a fixed time interval, under a secret one-way function and sending the encrypted message, herein called "dynamic user identifier", to the user's "home authority" where he/she is registered. The home authority comprises correspondence tables listing, pre-computed for every time interval (or another chosen synchronization), the dynamic user identifiers and the corresponding true identity of the user and can thus quickly decide whether the received encrypted message originates from a registered user. On the other hand, an intruder is neither able to detect from the encrypted messages the identity of the user nor can he/she track a user's moves.
Patent CA-2204493-C (CA)
Title: Application of superoxide dismutase in liposomes
Inventor: FURNSCHLIEF ECKHARD
IPC: A23L5/20
Filed: 1995-11-06
Granted: 2009-04-14
Abstract: Superoxide dismutase (SOD), preferably rhSOD, is used in liposomes, optionally mixed with hyaluronic acid and/or at least one physiologically acceptable carrier, and other optional additives, to prepare a pharmaceutical composition useful against increased concentrations of superoxide radicals and/or the damage caused thereby. These compositions can be administered topically, orally and/or parenterally to prevent and/or heal in particular burns, skin lesions due to radiation, inflammations, rheumatic and arthritic diseases, bronchitis, ARDS, emphysema, allergic oedemas and other inflammatory process, possibly triggered by microbial infections. They may also be used in the cosmetic treatment of furuncles, acne and the like. Also disclosed is a process for improving the preservability of organic, preferably biogenic, materials, in particular organ transplants and liquids with organic components, as well as foodstuffs, by using the disclosed compositions.
Patent CA-2205006-C (CA)
Inventor: HEIM ROGER
IPC: C12P21/04
Filed: 1995-11-13
Granted: 2001-07-24
Abstract: En modifiant la séquence de la protéine fluorescente verte (PFV) native de Aequorea, on obtient des produits ayant des spectres d'excitation et d'émission qui sont nettement différents de ceux de la PFV native correspondante. Dans une forme d'exécution, le produit correspondant à une PFV modifiée présente une altération dans le rapport des deux pics d'excitation principaux, par rapport à celui observé avec le produit correspondant à la PFV native. Dans une autre forme d'exécution, le produit correspondant à une PFV modifée présente une fluorescence à une longueur d'onde plus courte que le produit correspondant à la PFV native. Dans une autre forme d'exécution encore, le produit correspondant à une PFV modifiée ne présente qu'un seul pic d'excitation et il présente une émission accrue par comparaison avec le produit dérivé de la PFV native.