baber/WOPTO huggingface dataset:
Patent NZ-556125-A (NZ)
Title: Pyrazine derivatives for inhibiting RAF activity
Inventor: SPRINGER CAROLINE JOY
IPC: A61K31/444
Filed: 2005-12-22
Abstract: Disclosed is an aminopyrazine derivative of formula (I), wherein W is -NRN4-, -O-, or -S-, RN4 is H or C1-4alkyl, Y is an optionally substituted carbocycle or heteroaryl, Z is optionally substituted phenyl, and wherein the optional substituents are as defined in the specification. Also disclosed by the specification are pyrazine and pyridine derivatives of formula (II), wherein Q is N or CH, and wherein the other substituents are as defined in the specification. Also disclosed is the use of any of the above compounds for inhbiting RAF activity and for treating conditions ameliorated by the inhibition of RAF, such as cancer, melanoma, or malignant melanoma.
Patent NZ-561145-A (NZ)
Title: Pyrazolylaminopyridine derivatives useful as kinase inhibitors
Inventor: DAVIES AUDREY
IPC: A61K31/4439
Filed: 2006-02-01
Abstract: Disclosed is a compound of formula (I) wherein one of X1, X2, X3 and X4 is =N-, the other three are independently selected from =CR8, =CR9- and =CR10-, A is a direct bond or optionally substituted C1-2alkylene, Ring C is carbocyclyl or heterocyclyl, and wherein the rest of the substituents are disclosed within the specification. Also disclosed is a process for preparing a compound of formula (I). Also disclosed is the use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of Trk activity, for the treatment or prophylaxis of cancer or for use in the production of an anti-proliferative effect.
Patent NZ-566406-A (NZ)
Title: Fermentive production of four carbon alcohols
Inventor: DONALDSON GAIL K
IPC: C12N1/19
Filed: 2006-10-25
Abstract: A recombinant microbe capable of producing isobutanol, which comprises enzymes that can catalyse the reactions: (i) Pyruvate to acetolactate (step a); (ii) Acetolactate to 2,3-dihydroxyisovalerate (step b) (iii) 2,3-dihydroxyisovalerate to alpha-ketoisovalerate (step c) (iv) Alpha-ketoisovalerate to isobutyraldehyde (step d), or alternatively the reactions: a. alpha-ketoisvalerate to isobutyryl-CoA (step f); and b. Isobutyryl-CoA to isobutyraldehyde (step g); (v) Isobutyraldehyde to isobutanol (step e).
Patent NZ-567688-A (NZ)
Title: Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
Inventor: MENG XIANG-JIN
IPC: A61K39/00
Filed: 2002-12-11
Abstract: Disclosed is an in vitro process for the production of an immunogenic polypeptide product, said process characterized by comprising: growing, under suitable nutrient conditions, isolated prokaryotic or eucaryotic host cells transfected with a chimeric nucleic acid molecule of porcine circovirus (PCV1-2) in a manner allowing expression of said polypeptide product, and isolating the desired polypeptide product of the expression of said chimeric nucleic acid molecule, wherein said chimeric nucleic acid molecule has a nucleotide sequence set forth in SEQ ID NO:2, its complementary strand or a nucleotide sequence which has at least 95% 10 homology to the nucleotide sequence of SEQ ID NO:2. Also disclosed is a viral vaccine comprising a chimeric nucleic acid molecule of PCV1-2 and a porcine antigen.
Patent NZ-568325-A (NZ)
Title: Macrocyclic oxygen linked pyrimidine derivatives
Inventor: BLANCHARD STEPHANIE
IPC: A61K31/505
Filed: 2006-11-15
Abstract: Disclosed is a macrocyclic compound of formula (I), or a salt, N-oxide, or prodrug thereof, where the substituents are as defined in the specification. Also disclosed is the use of the above compound for treating conditions affected by inhibition of a protein kinase, such as prostate cancer, retinoblastoma, malignant neoplasm of breast, malignant tumour of colon, endometrial hyperplasia, osteosarcoma, squamous cell carcinoma, non-small cell lung cancer, melanoma, liver cell carcinoma, malignant neoplasm of pancreas, myeloid leukemia, cervical carcinoma, fibroid tumour, adenocarcinoma of the colon, T-cell leukemia, glioma, glioblastoma, oligodendroglioma, lymphoma, ovarian cancer, restenosis, astrocytoma, bladder neoplasms, musculoskeletal neoplasms and Alzheimer's Disease.
Patent NZ-571370-A (NZ)
Title: System and method for remotely attended delivery
Inventor: PAI SAMUEL HONG-YEN
IPC: G06Q10/08
Filed: 2007-02-20
Abstract: A method for remotely monitoring deliveries is disclosed. A logical receiving area (304) defined by one or more logical walls (306) is established. The logical receiving area has an access point (208, 210). An arrival of a delivery at the access point is detected and a monitoring centre is notified of the arrival of the delivery at the access point. At least one verification detail is verified with the at least one verification detail correlating to the delivery. A configuration signal is sent from the monitoring centre to the access point with the configuration signal having instructions for controlling an entrance at the access point. The logical walls are monitored in response to allowing the delivery into the logical receiving area through the access point. The logical receiving area is partitioned from a remainder of a building by the one of more logical walls. The one of more logical walls are created by either optical signals or sensors.
Patent NZ-574390-A (NZ)
Title: Fatty acid blends and uses therefor in fuel
Inventor: KNUTH MARK E
IPC: C07B53/00
Filed: 2007-06-27
Abstract: A mixture of fatty acid alkyl esters that comprises: (i) At least 50 percent by weight of saturated medium chain fatty acid alkyl esters that have 6-14 carbons, myristoleic acid alkyl ester and monosaturated long chain fatty acid alkyl esters having more than 18 carbons; and (ii) Less than 10 percent by weight myristic acid alkyl ester and saturated long chain acid alkyl esters. The mixture comprises either (1) lauric acid alkyl ester (C12:0) at 5 to 20 percent by weight of the mixture or (2) the mixture comprises 15 to 40 percent fatty acid alkyl esters having 6-14 carbons and 60 to 85 percent monosaturated fatty acid alkyl esters having more than 18 carbons. The mixture can be used as a fuel for an internal combustion engine; in particular the mixture is used in a biodiesel blend.
Patent NZ-579301-A (NZ)
Title: 2-Imino-3,6-dimethyl-5,6-diphenyl-tetrahydropyrimidin-4-one derivatives for treatment of Alzheimer's disease
Inventor: ZHU ZHAONING
IPC: C07D239/22
Filed: 2008-02-20
Abstract: Disclosed are 2-imino-3,6-dimethyl-5,6-diphenyl-tetrahydropyrimidin-4-one derivatives as represented by the general formula (I), wherein R2 is hydrogen; R1 is methyl; W is C(=O); one of R3 or R4 is hydrogen, and the other is an optionally substituted phenyl group; U is C(R6)(R7), where one of R6 or R7 is methyl, and the other is an optionally substituted phenyl group; and X is NH. Representative compounds include 2-imino-3,6-dimethyl-5-(4-trifluoromethylphenyl)-6-(2,4-difluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-trifluoromethylphenyl)-6-(2-fluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(1,1-difluoroethyl)phenyl)-6-(2-fluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(1,1-difluoroethyl)phenyl)-6-phenyl-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(tert-butyl)phenyl)-6-(2,4-difluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-trifluoromethylphenyl)-6-(2,6-difluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-trifluoromethylphenyl)-6-(2,5-difluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(1,1-difluoroethyl)phenyl)-6-(4-fluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(1,1-difluoropropyl)phenyl)-6-(2,4-difluorophenyl)-tetrahydropyrimidin-4-one, 2-imino-3,6-dimethyl-5-(4-(1,1-difluoroethyl)phenyl)-6-(2,4,6-trifluorophenyl)-tetrahydropyrimidin-4-one and 2-imino-3,6-dimethyl-5-(4-(1,1-difluoroethyl)phenyl)-6-(2,4-difluorophenyl)-tetrahydropyrimidin-4-one. Further disclosed is a pharmaceutical composition which comprises a compound as defined above, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, a pharmaceutically acceptable carrier, and optionally one or more additional active agents (such as a cholinesterase inhibitor selected from tacrine, donepezil, rivastigmine, galantamine, pyridostigmine and neostigmine) for treating a cognitive or neurodegenerative disease such as Alzheimer's disease.
Patent NZ-579901-A (NZ)
Title: Waterproof controller and orientation sensor for life-saving apparatus
Inventor: LAHYANI IRIS
IPC: B63C9/08
Filed: 2008-02-21
Abstract: A life-saving apparatus for use in an aquatic environment. The apparatus includes: a) a water-proof controller (618) mountable on a user disposed in an aquatic environment, for analyzing data related to the user and for initiating a life saving operation after the user has been in an actual or impending distress for a predetermined time; and b) an orientation sensor (644) for sensing the angle of the longitudinal axis of the user with respect to the water surface and for sending a first signal to the controller to initiate the life saving operation when the angle is indicative of a predetermined angular deviation for a first predetermined threshold time. The apparatus also includes an inflatable life-saving swimming garment (600) for a swimmer that comprises an inflatable part (12) for floating the swimmer while being in distress and for creating, when inflated, volume difference between upper body part and lower body part of the swimmer. The garment also includes an inflating system that consists of a gas tank with compressed gas for inflating the inflatable part; and a controllable valve connecting between the air tank and the inflatable part, for allowing the compressed gas to inflate the inflatable part; and a battery for supplying power for the operation of the controller and the valve.
Patent NZ-585897-A (NZ)
Title: Method of mixing a slurry using a constriction valve using a plurality of rods arrayed around a flexible conduit
Inventor: PETERSEN BRUCE LYNN
IPC: B28B19/00
Filed: 2005-04-12
Abstract: An apparatus (10) and method for controlling the flow of a slurry (S) is disclosed. The method uses a constrictor valve (32) on a mixing and dispensing apparatus. The constrictor valve includes a first guide plate and a second guide plate that are spaced a distance apart along the length of the conduit. Extending between the two guide plates, a plurality of elongate members (30) have first and second ends engaged on the first and second guide plates. Upon rotation of at least one of the first and second guide plates, the elongate members are configured to impart pressure on, and constrict the conduit to approximate a hyperboloid of rotation about a longitudinal axis of the conduit. Constriction of the conduit may be achieved automatically by sensing a factor such as the electromotive loading on the mixer motor, the flow rate through the dispensing system, the pressure in the mixing or dispensing system, the viscosity of the slurry or the electromotive loading on the actuator. Reproducible precision in the amount of constriction of the conduit can be achieved with the actuator configuration since the amount of constriction of the conduit is directly related to the amount of rotation of the guide plate.
Patent NZ-586846-A (NZ)
Title: An improved mutagenesis method using polyethylene glycol mediated introduction of mutagenic nucleobases into plant protoplasts
Inventor: BUNDOCK PAUL
IPC: C12N15/11
Filed: 2007-12-21
Abstract: Disclosed is a method for targeted alteration of a duplex acceptor DNA sequence in a plant cell protoplast, comprising combining the duplex acceptor DNA sequence with a donor single-stranded (ss) mutagenic nucleobase, wherein the duplex acceptor DNA sequence contains a first DNA sequence and a second DNA sequence which is the complement of the first DNA sequence and wherein the donor mutagenic nucleobase comprises at least one mismatch with respect to the duplex acceptor DNA sequence to be altered, preferably with respect to the first DNA sequence, wherein the method further comprises a step of introducing the mutagenic nucleobase into the cell protoplasts using polyethylene glycol (PEG) mediated transformation. Further disclosed is the use of PEG mediated transformation for enhancing the efficiency of targeted mutagenesis in plant protoplasts, wherein a mutagenic nucleobase is used, wherein the mutagenic nucleobase is a ss mutagenic nucleobase.
Patent NZ-587154-A (NZ)
Title: Foam proportioning system with low-end controller and foam pump
Inventor: HOSFIELD ROBERT L
IPC: A62C5/02
Filed: 2009-01-05
Abstract: Disclosed is a foam proportioning system (100) with a foam pump (118). The system includes at least one foam line (132) which is in fluid communication with a source of liquid foam concentrate, at least one discharge line (133), and the foam pump. The system has a divert (103) having a recirculation line (134) and a low-end control valve (128), the recirculation line having a first end positioned downstream of the foam pump and a second end positioned upstream of the foam pump. The divert is operable to direct a portion of a flow of the liquid foam concentrate through the recirculation line. The system further has at least one controller (104) in communication with the foam pump and divert. The controller is configured to automatically operate the foam pump and the divert to maintain a minimum flow rate of the liquid foam concentrate through the foam pump. The low-end control valve is in communication with the at least one controller, operating in response to a signal from the at least one controller, and automatically opening when a foam demand is less than the minimum flow rate of the liquid foam concentrate through the foam pump.
Patent NZ-588884-A (NZ)
Title: Cross-linkers and their uses
Inventor: CHARI RAVI V J
IPC: C07K17/00
Filed: 2009-04-30
Abstract: Disclosed herein are cross linkers of formula (I), wherein the substituents are as defined within the specification, processes for their preparation, cell-binding agent-drug conjugates comprising said linkers and uses thereof.
Patent NZ-591289-A (NZ)
Title: A whipping agent
Inventor: KIELMEYER FRIEDRICH
IPC: A23L9/10
Filed: 2009-10-08
Abstract: Patent No. 591289 Disclosed is a whipping agent comprising at least one fat, at least one protein and at least one emulsifier, wherein the at least one emulsifier is different from the at least one protein, and wherein the amount of all emulsifiers present in the whipping agent is at least 5 % by weight of the whipping agent, and wherein the amount of unsaturated fatty acid moieties present in the fat is at least 30% by weight of all fatty acid moieties present in the fat.
Patent NZ-593341-A (NZ)
Title: An Article including Identification Information for use in an Electrically Heated Smoking System
Inventor: FERNANDO FELIX
IPC: A24F40/85
Filed: 2009-12-24
Abstract: 593341 Disclosed is an electrically heated smoking system for receiving a smoking article including identification information printed thereon. The system includes a cavity for at least partially receiving the smoking article. The system also includes at least one heating element with a power supply for supplying power to the at least one heating element, electrical hardware connected to the power supply and the at least one heating element and a detector. The detector is capable of detecting the presence of the smoking article in the cavity and distinguishing the smoking article from other articles configured for use with the smoking system based on the identification information printed on the smoking article.
Patent NZ-596772-A (NZ)
Title: Method for producing peroxymonosulfuric acid (also known as persulfuric acid, peroxysulfuric acid, or Caro's acid)
Inventor: YOSHIDA KIYOSHI
IPC: C01B15/08
Filed: 2007-10-18
Abstract: Disclosed is an apparatus when used to continuously produce peroxymonosulfuric acid (H2SO5, also known as persulfuric acid, peroxysulfuric acid, or Caro's acid), comprising: a) a first static mixer for mixing hydrogen peroxide with sulfuric acid to react them, thereby obtaining a reaction solution; b) a second static mixer for mixing the reaction solution obtained in the first static mixer with a dilution water; and c) a reaction solution transporting pipe for transporting the reaction solution from the first static mixer to the second static mixer; with the first static mixer and the reaction solution transporting pipe being disposed underwater in a vessel thereby cooling the reaction solution to a temperature range of 25 degree C-50 degree C within five minutes after initiation of the mixing of the hydrogen peroxide with sulphuric acid.
Patent NZ-596782-A (NZ)
Title: A centrifugal separator
Inventor: KJAER ALLAN OTTO
IPC: B04B1/20
Filed: 2010-06-11
Abstract: 596782 Disclosed is a centrifugal separator with a feed accelerator system to reduce turbulence and improve separation. The centrifugal separator has a rotating bowl (3) and a rotating conveyor (5) with an acceleration chamber (43) arranged coaxially within the bowl (3). The centrifugal separator further has a separation chamber (45), which is radially limited by the bowl (3) and the conveyor (5), respectively, and the acceleration chamber is provided with feed ports for inlet of feed material into the separation chamber (45). A feed accelerator is arranged coaxially within the acceleration chamber (43) and is rotating in use around a common axis of rotation relative to the conveyor at a lower speed than the conveyor. The feed accelerator has a discharge outlet for discharge of feed material into the acceleration chamber (43) of the conveyor. The feed ports extend a first axial area (49) and the discharge outlet extends a second axial area (82), whereby the first and the second axial area are overlapping.
Patent NZ-597881-A (NZ)
Title: Method of treating sewage sludge by tumbling and heating in drum, including ascertaining rate of moisture evaporation
Inventor: CHRISTY RICHARD W
IPC: A61L2/04
Filed: 2007-10-09
Abstract: A method of treating sewage sludge by heating and/or evaporating and/or pasteurizing and/or otherwise chemically treating material comprising sludge and any added ingredients. The method includes: (a) providing a drum (D); (b) delivering (40, 41, 42) the material to the drum; (c) tumbling (126) the material within the drum; (d) heating the material in the drum; (e) drawing off moisture gases being evaporated from the material in the drum; (f) discharging (135) the material from the drum via a discharge outlet (134); and (g) ascertaining the rate of evaporation of moisture from the drum. Several techniques are provided for ascertaining the rate of evaporation of moisture from the drum. The method may also include: (h) adding material into the drum in amounts responsive to the rate of evaporation of moisture from the drum.
Patent NZ-598191-A (NZ)
Title: Meter processing communication system
Inventor: REE BRADLEY RICHARD
IPC: G01F15/06
Filed: 2012-02-13
Abstract: Disclosed is a utility meter communication system (100). The system (100) is comprised of a utility meter (110) and a central processor (140) integrated with the utility meter (110). The central processor (110) includes a single communications stack (150). The single communications stack (150) and central processor (140) are configured to process communications between a plurality of different networks (120, 130).
Patent NZ-598943-A (NZ)
Title: Hbv antisense inhibitors
Inventor: HAMATAKE ROBERT
IPC: A61K31/7115
Filed: 2010-10-15
Abstract: Disclosed is an antisense oligomer for use in reducing the amount of a hepatitis B virus DNA and HBV antigen in a mammalian cell or an organism, wherein the antisense oligomer consists of 16 nucleotides comprising the sequence of any one of SEQ ID NOs 14-22 (the sequences are as defined in the specification) and wherein the antisense oligomer comprises at least one LNA nucleic acid monomer having a chemical link between a 2’- and 4’- atom of the nucleoside sugar, or a salt, solvate, hydrate or ester thereof.
Patent NZ-599202-A (NZ)
Title: Air freshening device
Inventor: TUCKER CHRISTOPHER S
IPC: A61L9/00
Filed: 2010-10-13
Abstract: Disclosed is an air freshening device. The device has a liquid supply to supply liquid fragrance material (10) and a wick (20) in contact with liquid (10) in the liquid supply. A conductive mesh material (55) of about 200 mesh to about 600 mesh is included to retain the liquid material (10) in interstices thereof. A power supply applies voltage across a heater (50) which includes the conductive mesh material (55) so as to heat the liquid material (10) contained in interstices of the mesh material (55) to a temperature sufficient to vaporize the liquid (10). The air freshening device is also prevents deposition of the vaporized liquid material (10).
Patent NZ-599899-A (NZ)
Title: Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites
Inventor: MACKEL MICHAEL JOHN
IPC: A61P35/00
Filed: 2010-11-10
Abstract: Disclosed is a composition comprising Glycine-Arginine-Glycine-Cysteic(Acid)-Threonine-Proline; and its use for inhibiting adhesion to RGD binding sites in a human or animal subject.
Patent NZ-600549-A (NZ)
Title: Protein concentrates and isolates, and processes for the production thereof
Inventor: TANG QINGNONG NELSON
IPC: A23J3/14
Filed: 2010-11-10
Abstract: Disclosed is a protein isolate comprising a protein content of at least 90% (w/w) protein comprising: i) a first protein fraction comprising between 10% (w/w) and 40% (w/w) 2S protein; and ii) a second protein fraction comprising between 30% (w/w) and 70% (w/w) 12S protein. Further disclosed is a protein isolate comprising a protein content of at least 90% (w/w) protein comprising: (i) a first class of proteins having a molecular weight between 225 and 275 kDa, the first class of proteins comprising between 50-70% (w/w); (ii) a second class of proteins having a molecular weight between 40 and 60 kDa, the second class of proteins comprising between 3-8% (w/w); (iii) a third class of proteins having a molecular weight between 20 and 40 kDa, the third class of proteins comprising between 2-6% (w/w); (iv) a fourth class of proteins having a molecular weight between 7 and 15 kDa, the fourth class of proteins comprising between 10-20% (w/w); (v) a fifth class of proteins having a molecular weight between 3 and 10 kDa, the fifth class of proteins comprising between 10-20% (w/w); and (vi) a sixth class of proteins having a molecular weight of less than about 5 kDa and comprising less than about 1 % (w/w) of the protein isolate. Further disclosed is a process for producing a protein isolate from an oilseed meal, the process comprising: i) mixing the oilseed meal with a first blending solvent to form a mixture; ii) optionally treating the mixture with phytase at a temperature and a pH suitable for phytase activity; iii) optionally adjusting the pH of the mixture to solubilize proteins in the mixture; iv) subjecting the mixture to a g-force sufficient to separate the mixture to form a) a fiber fraction, and b) a protein fraction comprising (i) an insoluble protein fraction, and (ii) a soluble protein fraction; v) separating the insoluble protein fraction from the soluble protein fraction to recover therefrom an insoluble protein concentrate and a soluble protein extract; and vi) subjecting the soluble protein extract to membrane filtration to recover therefrom the protein isolate.