baber/WOPTO huggingface dataset:
Patent JP-2023541316-A (JP)
Title: 平面状のサセプタ素子の効率的かつ一貫した加熱を提供する誘導加熱エアロゾル発生システム
IPC: A24F40/465
Filed: 2021-09-21
Abstract: エアロゾル発生システムであって、液体貯蔵部（４０）と、液体貯蔵部（４０）からの液体が使用中にサセプタ素子に運ばれるように、液体貯蔵部と流体連通するサセプタ素子を含むサセプタ組立品（１２）であって、サセプタ素子が、実質的に平面状で、第１の平面に平行に延びる、サセプタ組立品（１２）と、第１のインダクタコイル（６６）及び第２のインダクタコイル（６８）であって、第１のインダクタコイル（６６）が、サセプタ組立品（１２）の第１の側面上に位置付けられ、かつ第１の平面に平行に延び、第２のインダクタコイル（６８）が、第１の側面とは反対側のサセプタ組立品（１２）の第２の側面上に位置付けられ、かつ第１の平面に平行に延び、サセプタ素子が、第１のインダクタコイル（６６）と第２のインダクタコイル（６８）との間に位置付けられ、かつそれらから実質的に等距離である、第１のインダクタコイル及び第２のインダクタコイルと、第１及び第２のインダクタコイル（６６、６８）に接続され、第１及び第２のインダクタコイル（６６、６８）に交流電流を提供するように構成された制御回路（７０）と、を備える、エアロゾル発生システム。この配置は、サセプタ素子の効率的かつ一貫した加熱を可能にする。【選択図】図１ｂ
Patent JP-2023548069-A (JP)
Title: 抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬
IPC: A61K39/395
Filed: 2021-11-02
Abstract: 本発明は、ＣＤ２０陽性細胞増殖性障害（例えば、非ホジキンリンパ腫等のＢ細胞増殖性障害）を有する対象の処置に関する。より具体的には、本発明は、抗ＣＤ２０／抗ＣＤ３二重特異性抗体の皮下投与によるＢ細胞増殖性障害を有する対象の処置に関する。【選択図】なし
Patent JP-2023550283-A (JP)
Title: マイクロキャビティプレート
IPC: C12M3/00
Filed: 2021-10-27
Abstract: マイクロキャビティプレートは、マイクロキャビティ基板と基部（３０３）とを備える。基部は、規則的な行列状に配置されることにより複数の開口部を形成する複数のグリッドセグメントを備える下部グリッドと、下部グリッドの外周から鉛直方向に延びる複数の側壁（３０９）を備える開ウェル（３０７）と、を備える。マイクロキャビティ基板は、下部グリッドの複数の開口部と位置合わせされた規則的な行列状に配置された複数のマイクロキャビティ（３１５）であって、各マイクロキャビティが、下部グリッドの開口部内に配置されるキャビティを有している、複数のマイクロキャビティを備える。マイクロキャビティプレートは、基部の規則的な行列を区切る下部グリッド上に配置されるように構成される上部グリッド（４０５）をさらに備えることができる。
Patent JP-2023550472-A (JP)
Title: ラパマイシン組成物
IPC: A61K31/439
Filed: 2021-11-04
Abstract: ラパマイシンは、公知の医学的治療物質である。ラパマイシンに関する問題は、ラパマイシンが非常に不安定であり、保存中に化学分解を起こしやすいことである。これにより、医薬品がその貯蔵寿命の間に「力価不足」になる可能性がある。少なくとも何らかの方法でこれに対処することが本発明の目的である。本発明は、活性成分としてのラパマイシン；例えばモノラウリン酸グリセリルとしてのモノラウリン及び例えばモノミリスチン酸グリセリルとしてのモノミリスチン；並びに溶媒としての水を含む、局所治療用組成物である。
Patent JP-2023551699-A (JP)
Title: 秤量センサの構造体
IPC: G01G21/24
Filed: 2021-12-03
Abstract: 本発明は、ロバーバル機構を有する秤量センサの構造体であって、ロバーバル機構の固定脚部を有する第１の部分と、ロバーバル機構の可動脚部を有する第２の部分と、ロバーバル機構の上側横方向リンクを有する第３の部分と、ロバーバル機構の下側横方向リンクを有する第４の部分と、可動脚部を感知測定の役割を果たす出力側に接続するレバー構成を有する第５の部分と、可動脚部をレバー組立体に結合させる横断方向リンクを備える第６の部分とを備え、第１の部分から第５の部分のうちの少なくとも１つは、少なくとも１つのタイプのハンドル体の形態の領域を備え、その少なくとも１つの孔は、前記領域に一体的に接続された第１の部分から第６の部分のうちの別のものの少なくとも１つの部分によって貫通される、構造体に関する。【選択図】図１
Patent JP-2023552547-A (JP)
Title: 拡散強調磁気共鳴画像から胎児の脳室容積を判定するためのコンピュータ実装方法及びシステム、並びに関連するｎｍｒ脳室容積評価方法
IPC: A61B5/055
Filed: 2021-11-29
Abstract: 本発明は、ＤＷＩと呼ばれる拡散強調磁気共鳴画像から、胎児の脳室容積を判定するためのコンピュータ実装方法に関し、以下のステップを実行することを含む。Ａ．２００～１０００ｓ／ｍｍ２の範囲内で選択された単一のｂ値によって行われる（１１１）、胎児の脳室の、予め設定されたボクセルの高さを有するＤＷＩ画像を取得するステップ（１１２）。Ｂ．脳室の周囲のＤＷＩ画像のそれぞれにおいてＲＯＩを選択するステップ（１２２，１２３，１２４，１２５）。Ｃ．ＲＯＩの画素を自動的にクラスタ化して（１２７）、クラスタ化されたＤＷＩ画像を取得するステップ。Ｄ．ＤＷＩ画像及び予め設定されたボクセルの高さのそれぞれについて、ＲＯＩ内の画素の数に基づいて、脳室容積を計算するステップ（１３０）。さらに、本方法は、本発明の方法を用いるＮＭＲ評価システム及びＮＭＲ評価方法に関する。
Patent JP-2023545868-A (JP)
Title: 環境制御を有する３次元マットレスシステム
IPC: A47C27/00
Filed: 2021-10-11
Abstract: ３次元の身体支持をユーザに提供するように構成され得る、環境制御を有する３次元マットレスシステムが提供される。いくつかの実施形態では、本システムは、フレーム空洞を形成し得る剛性フレームを含み得る。任意選択的に、本システムは、１つ又は複数の温度調整器を含み得る。複数の枕がフレーム空洞内に配置され得、及びユーザは、複数の枕によって支持され得る。任意選択的に、１つ又は複数の換気デバイスは、複数の枕を通して空気をフレームの外に移動させるように構成され得、及び１つ又は複数の空気フィルタは、換気デバイスによって移動される空気を濾過するように構成され得る。
Patent JP-2024503281-A (JP)
Title: 回転可能ノブインタフェース
IPC: G06F3/0362
Filed: 2022-01-06
Abstract: 回転可能インタフェースのズレを検出する方法が開示される。該回転可能インタフェースは、底面に導電性領域を有する固定基部を有しており、固定基部が入力装置の表示画面に取り付けられる。当該方法は、第１期間に、それぞれ導電性領域に容量カップリングされた入力装置の第１セット及び第２セットの電極に基準信号を提供することを含む。該方法は、更に、第２期間に、電極の前記第１セットに基準信号を供給し、電極の前記第２セットに検知信号を供給し、電極の前記第２セットで結果信号を受信することを含む。該方法は、更に、前記入力装置の前記表示画面に対する前記回転可能インタフェースの平行移動を、前記第２期間における前記結果信号の値に少なくとも部分的に基づいて判定することを含む。
Patent JP-2024502331-A (JP)
Title: 医療廃棄物を処理するためのチャンバ、システムおよび方法
IPC: B09B3/70
Filed: 2021-11-17
Abstract: 本発明は、搬入モード、処理モードおよび搬出モードのいずれか１つで動作するように構成され、処理モードにおいて、オゾンを使用して医療廃棄物の粒子を消毒するための処理チャンバ（１００）内の環境を提供するようにさらに構成された廃棄物処理チャンバ（１００）に関し、処理チャンバは、搬入モードにおいて、医療廃棄物の粒子を受け入れるように構成され、処理モードおよび搬出モードにおいて、処理チャンバ（１００）の内部の環境と外部の環境との間に密封シールを提供するように構成された入口（１１０）と、搬出モードにおいて、処理チャンバ（１００）から医療廃棄物の粒子を取り出すように構成され、搬入モードおよび処理モードにおいて、処理チャンバ（１００）の内部の環境と外部の環境との間に密封シールを提供するように構成された出口（１２０）と、搬入モードおよび処理モードにおいて、医療廃棄物の粒子を攪拌するように構成され、搬出モードにおいて、医療廃棄物の粒子を取り出しのために出口（１２０）に移動させるようにさらに構成された粒子搬送装置（１３０）と、処理チャンバ（１００）内の封止環境の特性を測定するように構成された１つまたは複数のセンサ（Ｓ１、Ｓ２）とを備え、処理チャンバは、オゾンを生成し、処理チャンバ（１００）内の環境のオゾンのターゲット濃度レベルを維持するように構成された発生器（Ｇ）にさらに流体結合され、またはそれを備える。
Patent MX-2007001616-A (MX)
Title: Toothbrush and method of making the same.
Inventor: SORRENTINO ALAN V
IPC: A46B3/16
Filed: 2005-10-25
Abstract: A toothbrush that provides enhanced cleaning and oral care to a user. The toothbrush has a head with cleaning elements that create a contoured cleaning profile. The cleaning elements have different depths of insertion relative to a reference plane to define a contoured cleaning profile without post-fixing trimming of the cleaning elements. Accordingly, tapered bristles can be used to define a contoured cleaning profile. Alternatively, tapered bristles of different lengths can also be used to form a contoured cleaning profile.
Patent MX-2007004034-A (MX)
Title: Powder calcination process.
Inventor: BITOSSI MARCO
IPC: C09C1/00
Filed: 2004-10-07
Abstract: A process for the calcination of powders for the production of pigments for ceramic use is described, comprising calcination of the previously agglomerated powders in a continuous vertical kiln.
Patent MX-2007006940-A (MX)
Title: Method and device to reduce the energy consumption of an elevator. .
Inventor: LINDEGGER URS
IPC: B66B1/00
Filed: 2007-06-11
Abstract: The method involves detecting usage criteria using a current transducer (19.1). A lift system is brought from an operation mode into a stand-by mode, when the usage criteria are not satisfied and stand-by criteria are satisfied using a mode changing unit. The lift system is brought from the stand-by mode into the operation mode when the stand-by criteria are not satisfied. The usage criteria are satisfied, when a passenger is available in a cage and the lift system remains in the operation mode. Independent claims are also included for the following: (1) a current saving unit for reducing energy consumption of a lift system (2) a lift system with the current saving unit for reducing energy consumption of a lift system (3) a method for retrofitting the lift system with the current saving unit for reducing energy consumption of a lift system.
Patent MX-2007009205-A (MX)
Title: Closure lid for open mouth containers.
Inventor: BACKAERT DIMITRI M C J
IPC: B65D43/00
Filed: 2007-07-31
Abstract: A container lid for engagement within an open mouth container including upper and lower panels with the lower panel including a peripheral upwardly directed flexible flange seal, the upper panel being upwardly convex and, in cooperation with positioning posts on the lower panel, being selectively downwardly flexed toward the lower panel for an outward movement of the peripheral edge of the upper panel against the flange seal by an enhanced fulcrum action of the upper panel about a fulcrum extending upward from the lower panel in closely spaced inward relation to the flange seal.
Patent MX-2007011550-A (MX)
Title: A reactor system and process for the manufacture of ethylene oxide.
Inventor: CHEWTER LESLIE ANDREW
IPC: B01J19/30
Filed: 2006-03-20
Abstract: A reactor system for the epoxidation of ethylene, which reactor system comprises an elongated tube having an internal tube diameter of more than 40 mm, wherein contained is a catalyst bed of catalyst particles comprising silver and a promoter component deposited on a carrier, which promoter component comprises an element selected from rhenium, tungsten, molybdenum and chromium; a process for the epoxidation of ethylene comprising reacting ethylene with oxygen in the presence of the catalyst bed contained in the reactor system; and a method of preparing ethylene glycol, an ethylene glycol ether or an ethanol amine comprising obtaining ethylene oxide by the process for the epoxidation of ethylene, and converting the ethylene oxide into ethylene glycol, the ethylene glycol ether, or the ethanol amine. Preferably, the internal tube diameter is at least 45 mm.
Patent MX-2007012787-A (MX)
Title: Cutting segment, method for manufacturing cutting segment, and cutting tool comprising the same.
Inventor: KIM SOO-KWANG
IPC: B23D61/02
Filed: 2006-04-14
Abstract: A cutting segment for a cutting tool used for cutting or drilling brittle workpieces, such as stone, brick, concrete and asphalt, a method for manufacturing the segment, and a cutting tool comprising the segment are disclosed. The segment comprises layers of diamond particles and two kinds of plate-shaped metal matrix layers comprising soft and hard metal matrix layers having different ductility. The plate-shaped metal matrix layers are arranged perpendicular to a cutting surface while being parallel to a cutting direction, and are alternately stacked perpendicular to the cutting direction. The layers of diamond particles are suitably arranged in the plate-shaped soft and hard metal matrix layers. The segment and the cutting tool comprising the same have excellent cutting ability, and the manufacturing process thereof can be simplified, thereby remarkably enhancing productivity.
Patent MX-2007015814-A (MX)
Title: A product release system to atomize cosmetic hair or skin compositions containing uv filters.
Inventor: WEBER DIRK
IPC: A61Q17/04
Filed: 2006-06-20
Abstract: A product release system for atomizing cosmetic hair or skin compositions is described, which has (a) pressure-resistant packaging, (b) a capillary-containing spray head, and (c) a propellant-containing cosmetic composition containing at least one UV filter. The atomization is done using the capillary. The capillary preferably has a diameter of 0.004-0.04 in (0.1 to 1 mm) and a length of 0.2-4 in (5 to 100 mm). The spray rate is preferably 0.0004-0.2 oz/s (0.01 to 5 g/s). The composition can particularly be a gel, wax, or emulsion.
Patent MX-2008000783-A (MX)
Title: Chromium complex dyes.
Inventor: NUSSER RAINER
IPC: C09D11/02
Filed: 2006-07-17
Abstract: The present invention relates to novel 1 :2 chromium complex dyes, processes for their preparation and their use for dyeing or printing fibre materials containing hydroxyl groups or containing nitrogen. The present invention relates to a 1 :2 chromium complex dye of formula (I) wherein all substituents are as defined in the claims, a process for their preparation and their use for dyeing or printing fiber materials containing hydroxyl groups or containing nitrogen. The present invention relates to novel 1 :2 chromium complex dyes, processes for their preparation and their use for dyeing or printing fibre materials containing hydroxyl groups or containing nitrogen. The present invention relates to a 1 :2 chromium complex dye of formula (I) wherein all substituents are as defined in the claims, a process for their preparation and their use for dyeing or printing fiber materials containing hydroxyl groups or containing nitrogen. The invention relates to an arrangement with a piezoactuator, for example for operation of a mechanical component, in particular a piezo injector, comprising a multilayer construction of piezo layers (26), held in a retainer body (2;29,30) as a piezoelement (3;21) with an internal alternating contacting of inner electrodes (22, 23) with contact elements (24, 25) provided on the piezoelement (3;21). Electrical lines (34, 35) run through a head piece (30) of the retainer body (29) to the contact elements (24,25). The lines (34, 35) embedded in a fixed manner in the head piece (30) may be connected to the contact elements (24, 25) by means of contact connections (37, 38), said contact connections (37,38) being able to lie in a centering and/or insulation sleeve (39) in the actuator base (28, 27) on the piezoelement (21) after the assembly of the piezo injector (20).
Patent MX-2008004851-A (MX)
Title: Multi-piece shower wall system and method of installation.
Inventor: TORRES RAYMOND C
IPC: E04C2/00
Filed: 2008-04-11
Abstract: A vertical corner joint for joining a first shower wall panel having a J-shaped channel integrally formed on an edge thereof and second shower wall panel having a resilient, elongate wedge member attached to the back side and along an edge thereof. The edge with the wedge is inserted into the channel of the first panel, thus compressing the wedge and forming a tight corner joint or seam. A multi-piece shower enclosure may include one or more such joints. A four-piece enclosure may include a shower base or bathtub, a back wall with channels on both vertical edges, and two side walls, each with an edge with a wedge for insertion into a respective channel. The channel may form a nailing flange. A sealing strip may be included between the front side of the second panel and the short side of the channel.
Patent MX-2008005376-A (MX)
Title: Composition including superoxide dismutase and prickly-pear cactus for minimizing and preventing hangovers.
Inventor: DIAZ VICTOR HUGO
IPC: A23L1/00
Filed: 2008-04-25
Abstract: A composition protects against, minimizes the effects of, and hastens recovery from the typical symptoms associated with an alcohol induced hangover.
Patent MX-2008010691-A (MX)
Title: Acoustic carpet for vehicle.
Inventor: NICHOLLS DUNCAN
IPC: B27N3/10
Filed: 2007-02-01
Abstract: A vehicle carpet system has a continuous carpet base molded to the shape of the vehicle floor in which it is to be installed. The carpet base includes at least one layer of a molded noise-attenuating material, at least one molded recess formed therein. A removable acoustic carpet module fitted into the at least one recess and held in place by a releasable retainer.
Patent MX-2008011669-A (MX)
Title: Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine.
Inventor: SCHULTZ PETER G
IPC: C07K14/195
Filed: 2007-03-13
Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lipidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.
Patent MX-2008012850-A (MX)
Title: Portable dispenser.
Inventor: SCHLAUPITZ ROBERT SAMUEL
IPC: A47K10/42
Filed: 2007-01-16
Abstract: A spill proof, portable dispenser including a top attached to a bottom on a first side, a lid attached to the bottom on a second side, and wherein the top can only be opened after first opening the lid. Thus, when the dispenser is closed, the top is prevented from opening relative to the bottom unless the lid is first opened. The dispenser can be easily refilled by first opening the lid and then opening the top to access the dispenser's interior.
Patent MX-2008015615-A (MX)
Title: Oil sensor placement structure of engine.
Inventor: KOYAMA YOSHIAKI
IPC: F01M11/12
Filed: 2007-04-11
Abstract: In an engine, an oil level sensor (47) provided at the bottom of an oil pan (15) that contains engine oil and upstanding upward in the vertical direction is placed between a pair of balancer shafts (27, 28) that are received in parallel to each other in a balancer housing (21) provided between the lower surface of a cylinder block and the oil pan (15). A dead space formed between the pair of balancer shafts (27, 28) is effectively used to allow the oil level sensor (47) to be compactly received. Also, the pair of balancer shafts (27, 28) suppress agitation of the engine oil to prevent degradation of detection accuracy caused by splash of the oil on the oil level sensor (47).
Patent MX-2009003293-A (MX)
Title: Uwb apparatus and method.
Inventor: DESMOND PHILLIPS
IPC: H04B1/707
Filed: 2007-09-25
Abstract: An ultra-wideband receiver for processing a received signal comprising two or more diversity signals formed using a spreading technique at a transmitter comprises channel estimation means for estimating the channel over which the signal was transmitted. The receiver comprises inverting means for inverting the channel estimate obtained from the channel estimation means, the inverse of the estimated channel being applied to the received signal to generate a compensated signal. The receiver comprises means for weighting the compensated signal prior to demodulation using an estimate of noise in each channel, the estimate of the noise in each channel being derived from the inverse of the channel estimation process.
Patent MX-2009003789-A (MX)
Title: Discharge systems and methods of using the same.
Inventor: BLOOD MARK W
IPC: C08G85/00
Filed: 2007-09-10
Abstract: A discharge system for removing a solid/gas mixture from a fluidized bed pressure vessel is provided. The discharge system includes a fluidized bed pressure vessel, a settling vessel, a transfer vessel, discharge line, primary discharge valve, and primary exit valve. Also in included is a method to operate the discharge system. The method includes transferring a solid/gas mixture from a fluidized bed pressure vessel to a settling vessel, transferring the solids to a transfer vessel, and then emptying the transfer vessel.
Patent MX-2009005059-A (MX)
Title: Composition suitable for thin-wall injection molded articles.
Inventor: TORRES ENRIQUE
IPC: C08L23/14
Filed: 2008-01-09
Abstract: Compositions suitable for manufacturing injection molded articles having a minimum wall thickness of from 500 m to 2.0 mm comprise from: (A) 2 to 15% by weight of a propylene-ethylene copolymer having substantially is tactic propylene sequences; (B) 85 to 98% by weight of a random polypropylene copolymer having from 2.5 to 5.0% by weight units derived from ethylene and a melt flow rate of from25 to 130 grams/10 minutes (g/10min); and (C) 500 to 2500 ppm by weight of a nucleator/clarifier additive (based on the weight of the random polypropylene copolymer). Typically, the melt flow rate of the compositions is from 20 to 125 g/10min, and the propylene-ethylene copolymer comprises at least 75% by weight propylene and has a melt flow rate from4 to 30 g/10min.
Patent MX-2009007793-A (MX)
Title: Method and system for producing a hydrogen enriched fuel using microwave assisted methane decomposition on catalyst.
Inventor: ZHU ZHONGHUA JOHN
IPC: B01J19/00
Filed: 2008-01-13
Abstract: A method for producing a hydrogen enriched fuel includes the steps of providing a flow of methane gas, and providing a catalyst (56). The method also includes the steps of heating the catalyst (56) instead of the reactor walls and the methane gas using microwave irradiation at a selected microwave power, directing the flow of methane gas over the catalyst (56), and controlling the microwave power to produce a product gas having a selected composition. A system (10) for producing a hydrogen enriched fuel includes a methane gas source (16), a reactor (12) containing a catalyst (56), and a microwave power source (14) configured to heat the catalyst (56).
Patent MX-2009010064-A (MX)
Title: Methods and compositions for modulating il-17f/il-17a biological activity.
Inventor: COLLINS MARY
IPC: G01N33/68
Filed: 2008-03-28
Abstract: The invention provides a novel mouse IL-17F/IL-17A, and further provides uses of such mouse IL-17F/IL-17A in the characterization of the IL-17F/IL-17A heterodimer. The present invention is also related to polynucleotides and polypeptides of the IL-17F/IL-17A signaling pathway, and targeting of the IL-17F/IL-17A signaling pathway in methods of treating IL-17F/IL-17A- associated disorders. The invention thus provides methods of using isolated IL-17F/IL-17A heterodimer, e.g., in a mouse model of airway inflammation, and specific or selective IL-17F/IL-17A modulators (e.g., signaling agonists or signaling antagonists (e.g., specific or selective antagonistic antibodies, specific or selective antagonistic small molecules, etc.)). The invention also provides methods of screening for compounds capable of modulating IL-17F/IL-17A biological activity, e.g., IL-17F/IL-17A signaling antagonists (e.g., using the mouse model of airway inflammation), as well as methods of identifying whether the IL-17F/IL-17A modulator is a specific IL-17F/IL-17A modulator. The invention is also directed to novel methods for diagnosing, prognosing, monitoring, preventing, and/or treating IL-17F/IL-17A-associated disorders, including, but not limited to, inflammatory disorders (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., airway inflammation, chronic obstructive pulmonary disease, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets identified by methods of screening of the invention, and uses of such identified therapeutics in methods of treatment and prevention of IL- 17F/IL- 17A-associated disorders.
Patent MX-2009010223-A (MX)
Title: Adenosine a2a receptor antagonists.
Inventor: MOORMAN ALLAN R
IPC: A61K31/519
Filed: 2008-03-28
Abstract: The present invention provides compounds of the formula (I) wherein R1 and R2 have meaning as defined herein in the specification. The compounds of formula (I) are adenosine A2A receptor antagonists and, thus, may be employed for the treatment of conditions and diseases mediated by the adenosine A2A receptor activity. Such conditions include, but are not limited to, diseases of the central nervous system such as depression, cognitive function diseases and neurodegenerative diseases such as Parkinson's disease, senile dementia as in Alzheimer's disease or psychoses and stroke. The compounds of the present invention may also be employed for the treatment of attention related disorders such as attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD), extra pyramidal syndrome, e.g., dystonia, akathisia, pseudoparkinsonism and tardive dyskinesia, and disorders of abnormal movement such as restless leg syndrome (RLS) and periodic limb movement in sleep (PLMS); cirrhosis, and fibrosis and fatty liver; dermal fibrosis in diseases such as scleroderma; and the mitigation of addictive behavior. In particular, the compounds of the present invention may be employed to improve motor-impairment due to neurodegenerative diseases such as Parkinson's disease.
Patent MX-2009010242-A (MX)
Title: Azetidin compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor.
Inventor: UNGER LILIANE
IPC: C07D403/04
Filed: 2008-03-20
Abstract: The present invention relates to compounds of formula (I) wherein A is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-hydroxyalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C3-C6-cycloalkyl, aryl-C1-C4-alkyl, aryl-C2-C4-alkenyl, aryl or hetaryl; --- is a single or double bond; X1 and X2 are N, CRx1, NRx2 or CRx3Rx4; Rx1, Rx3 and Rx4 are H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylcarbonyl, etc. or two geminal radicals Rx3 and Rx4 together with the carbon atom to which they are bound may form a carbonyl group or a 3- to 6-membered carbocyclic or heterocyclic spiro- annulated ring; Rx2 is hydrogen, C1-C6-alkyl, C1-C6-alkylcarbonyl, C1-C6-haloalkyl, etc.; or two vicinal radicals Rx1, Rx2, Rx3 or Rx4 together with X1 and X2 form a five- or six- membered carbocyclic or heterocyclic fused ring; Y1, Y2 and Y3 are N or CRy; Ry is H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylcarbonyl, C1-C6-haloalkyl, etc.; wherein a maximum of 3 of the radicals X1, X2, Y1, Y2 and Y3 are selected from NRx1 and N; R1 is hydrogen, C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-haloalkyl, etc.; R2 is C1-C4-alkyl or C1-C4-haloalkyl; n is 0, 1 or 2; physiologically tolerated acid addition salts and the N-oxides thereof, pharmaceutical composition comprising them, a method for treating medical disorders selected from diseases of the central nervous system, addiction diseases or obesity, said method comprising administering an effective amount of such compounds to a subject in need and the use of such a compound for preparing a pharmaceutical compositions.