baber/WOPTO huggingface dataset:
Patent AP-1659-A (AP)
Title: Orally administered controlled drug delivery system providing temporal and spatial control.
Inventor: TALWAR NARESH
IPC: A61P31/10
Filed: 1999-01-19
Granted: 2006-09-06
Abstract: A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to float so that it is retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug, resulting in sustained release of the drug (temporla control). A preferred once daily ciprofloxacin formulation comprises 69.9% ciprofloxacin base, 0.34% sodium alginate, 1.03% xanthan gum, 13.7% sodium bicarbonate, 12.1% cross-linked polyvinylpyrrolidone, and optionally other pharmaceutical excipients, the formulation being in the form of a coated or uncoated tablet or capsule.
Patent DO-P2001000139-A (DO)
Title: Aparato surtidor y metodo
Inventor: TRAMONTINA PAUL F
IPC: A47K10/38
Filed: 2001-03-28
Abstract: Esta invención comprende un método y un aparato Para surtir más eficientemente y más fácilmente los productos de papel tal como el tisú para retrete, desde surtidores comerciales montados en la pared. La invención puede comprender proyecciones cargadas por resorte sobre el interior de la caja que están adaptadas para recibir y suspender dentro de la caja rollos de tisú de papel. Las puertas dentro de la caja están configuradas Para permitir la inserción de un nuevo rollo de papel adentro del surtidor cuando se localizan en la posición abierta; además, tales puertas suspenden la cola del rollo de papel para un fácil acceso al usuario del tisú cuando las puertas están en una posición cerrada. Una característica accesoria facilita el surtido de un tocón de rollo o de un rollo parcialmente consumido, así como un nuevo rollo, al volver a cargar el surtidor. Una o más ventanas son proporcionadas para permitir al personal de mantenimiento el determinar cuando se requiere el volver a cargar el surtidor.
Patent DO-P2015000290-A (DO)
Title: Benzoxazoles sustituidos
Inventor: ALLERHEILIGEN SWEN
IPC: C07D487/04
Filed: 2015-11-27
Abstract: LA INVENCIÓN SE REFIERE A BENZOXAZOLES SUSTITUIDOS Y A PROCESOS PARA SU PREPARACIÓN Y A SU USO PARA LA PREPARACIÓN DE MEDICAMENTOS PARA EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES, EN PARTICULAR DE TRASTORNOS CARDIOVASCULARES, PREFERIBLEMENTE DE TRASTORNOS TROMBÓTICOS O TROMBOEMBÓLICOS.
Patent DO-P2015000303-A (DO)
Title: Letermovir amorfo y formulaciones farmacéuticas sólidas del mismo para administración por vía oral
Inventor: SCHWAB WILFRIED
IPC: C07D239/84
Filed: 2015-12-18
Abstract: LA PRESENTE INVENCIÓN PROPORCIONA LETERMOVIR AMORFO Y FORMULACIONES FARMACÉUTICAS SÓLIDAS ADMINISTRABLES POR VÍA ORAL DEL MISMO (FORMULACIÓN DE LIBERACIÓN INMEDIATA). DICHO LETERMOVIR AMORFO ES ADECUADO PARA FORMULACIONES DE LIBERACIÓN INMEDIATA CUANDO SE AÍSLA DE UNA DISOLUCIÓN ORGÁNICA POR CUALQUIERA DE SECADO CON RODILLOS DE DICHA DISOLUCIÓN ORGÁNICA EN UN DISOLVENTE ORGÁNICO VOLÁTIL, EN PARTICULAR ACETONA, A UNA TEMPERATURA DE 30 ºC A 60 ºC, Y POSTERIORMENTE SECADO DEL LETERMOVIR AMORFO OBTENIDO, O AISLAMIENTO DE DICHO LETERMOVIR AMORFO MEDIANTE PRECIPITACIÓN EN DISOLVENTES MISCIBLES CON AGUA SELECCIONADOS DE ACETONA O ACETONITRILO EN EXCESO DE AGUA COMO ANTIDISOLVENTE, Y POSTERIORMENTE FILTRACIÓN O CENTRIFUGACIÓN DEL LETERMOVIR AMORFO OBTENIDO. LAS FORMULACIONES DE LIBERACIÓN INMEDIATA DE LETERMOVIR AMORFO ESTÁN PREVISTAS PARA SU USO EN MÉTODOS DE PROFILAXIS O MÉTODOS DE TRATAMIENTO DE ENFERMEDADES ASOCIADAS AL GRUPO DE HERPESVIRIDAE, PREFERENTEMENTE ASOCIADAS A CITOMEGALOVIRUS (CMV), INCLUSO MÁS PREFERENTEMENTE ASOCIADAS A CITOMEGALOVIRUS HUMANO (CMVH).
Patent DO-P2022000165-A (DO)
Title: MITORRIBOSCINAS: COMPUESTOS TERAPÉUTICOS BASADOS EN MITOCONDRIAS QUE FIJAN COMO OBJETIVO CÉLULAS CANCEROSAS, BACTERIAS y LEVADURAS PATÓGENAS
Inventor: FEDERICA SOTGIA
IPC: C07C275/24
Filed: 2022-08-11
Abstract: La presente descripción se refiere a inhibidores de la función mitocondrial. Se dan a conocer métodos de prospección de los compuestos para la inhibición mitocondrial. También se describen métodos para usar inhibidores mitocondriales llamados mitorriboscinas - compuestos terapéuticos basados en mitocondrias que tienen propiedades anti-cancerosas y antibióticas - para prevenir o tratar el cáncer, infecciones bacterianas y levadura patógena, así como también métodos para usar inhibidores mitocondriales para proporcionar beneficios anti-envejecimiento. También se dan a conocer compuestos específicos de mitorriboscina y grupos de mitorriboscinas.
Patent EC-SP12012160-A (EC)
Title: Compuesto heterociclico
Inventor: HOMMA MISAKI
IPC: C07D519/00
Filed: 2012-09-17
Abstract: Se proporciona un compuesto útil como un agente profiláctico o terapéutico para cáncer. Se describe específicamente un compuesto representado por la fórmula (I) (en donde cada símbolo es como se define en la descripción) o una sal del mismo, o un promedicamento del compuesto o la sal del mismo, el cual es útil para la prevención o tratamiento de cáncer.
Patent EC-SP13013073-A (EC)
Title: Derivados de benzamida sustituida
Inventor: NORCROSS ROGER DAVID
IPC: C07D413/14
Filed: 2013-12-10
Abstract: La presente invención se refiere a compuestos de la fórmulaen la que:R1 es hidrógeno, halógeno, ciano, alquilo inferior, alquilo inferior sustituido por halógeno, alcoxi inferior, alcoxi inferior sustituido por halógeno o C(O)NH2,o es fenilo opcionalmente sustituido por halógeno, ciano o alcoxi inferior sustituido por halógeno, o es 2,2-difluorbenzo[d][1,3]dioxol-5-ilo, o es 6-(trifluormetil)-pirazin-2-ilo o 5-(trifluormetil)pirazin-2-ilo o es 6-(trifluormetil)pirimidin-4-ilo, o es 6-(trifluormetil)-piridin-3-ilo, o es 5-cianopirazin-2-ilo o es 2-(tri-fluormetil)pirimidin-4-ilo;n es el número 1 ó 2R2 es halógeno, alquilo inferior o ciano y R3 es hidrógeno, oR2 es hidrógeno y R3 es halógeno, alquilo inferior o ciano;X es un enlace, -NR'-, -CH2NH- o -CHR'-;R' es hidrógeno o alquilo inferior; Z es un enlace, -CH2- u -O-;Ar es fenilo o es heteroarilo elegido entre el grupo formado por 1H-indazol-3-ilo, piridin-2-ilo, piridin-3-ilo, piridin-4-ilo, pirimidin-5-ilo, 1H-pirazol-3-ilo, 1H-pirazol-4-ilo y 1H-pirazol-5-ilo;o una sal de adición de ácido farmacéuticamente apropiada de los mismos; que pueden utilizarse para el tratamiento de la depresión, los trastornos de ansiedad, el trastorno bipolar, el trastorno de hiperactividad con déficit de atención (ADHD), los trastornos relacionados con el estrés, los trastornos psicóticos, la esquizofrenia, las enfermedades neurológicas, la enfermedad de Parkinson, los trastornos neurodegenerativos, la enfermedad de Alzheimer, la epilepsia, la migraña, la hipertensión, el abuso de sustancias, los trastornos metabólicos, los trastornos de ingestión de comida, la diabetes, las complicaciones diabéticas, la obesidad, la dislipidemia, los trastornos de consumo y asimilación de energía, los trastornos y malfunción de la homeostasis de la temperatura corporal, los trastornos del sueño y del ritmo circadiano y los trastornos cardiovasculares.
Patent EE-200200107-A (EE)
Inventor: THOR KARL BRUCE
IPC: A61K31/138
Filed: 2000-08-22
Abstract: Methods for the prevention, treatment or management of sexual dysfunction, as premature ejaculation, by administering to a patient in need of therapy a therapeutically effective amount of a rapid-onset selective serotonin reuptake inhibitor on an as-needed basis shortly before sexual activity.
Patent GB-189702692-A (GB)
Title: Improved Means of Winding Predetermined Lengths of Cord, Braid, Tape, Wool, Cotton, and like Material.
Inventor: STURGESS GEORGE FREDERICK
Filed: 1897-02-02
Granted: 1898-01-29
Abstract: 2692. Sturgess, G. F. Feb. 2. Reeling cords.-Relates to a machine fcr winding predetermined lengths of cord and the like. The machine shown is adapted for winding knots or hanks. The material is wound on arms, one of which is provided with a spring pin to which one end of the material to be wound may be attached. The arms are adjustable towards and from one another on the end of a spindle A, which may be driven by a cord B<1> and a hand-wheel or by a cord B and a power-driven pulley. The pulley C' is fixed to the spindle, but the pulley C is loose and drives the spindle by friction with a pulley N, the pulleys C, N being pressed together during the winding operation by a fork Q on the sliding spring rod P. The rod P is held in its working position by a loose catch P<1>. The spindle is connected by gearing D, E with a side shaft carrying a chain-wheel and chain, in the latter of which are projections or lugs at intervals which, when the spindle has made a certain number of revolutions, engage with an arm H on the spindle and stop the same. When the machine is driven by power, the projection on the travelling chain first disengages the spring rod P, whereby the friction clutch C, N is disengaged and a friction disc R is brought against the fixed pulley C' before the spindle is blocked by the lugs H. The material is guided during the winding operation by a traverse bar X carried by levers X<2>, X<3>, and is operated by the rotary cam W. When it is desired to restart the machine, the side shaft carrying the travelling chain is moved lengthwise by a spring lever S or treadle, whereby the projections on the chain are moved out of engagement with the projections H, and the rod P is moved longitudinally so as to disengage the brake disc R and place in gear the friction discs or pulleys C, N.
Patent GB-189705318-A (GB)
Title: Improvements in Embryotomy and Parturition Instruments Employed by Veterinary Surgeons.
Inventor: GOOCH GEORGE FREDRICK
Filed: 1897-02-27
Granted: 1898-02-26
Abstract: 5318. Gooch, G. F. Feb. 27. Obstetric appliances.-An embryotomy or parturition instrument for the use of veterinary surgeons consists of a pair of cutting-jaws or grippers B, pivoted to a frame K and actuated by a rod A, the screwed end of which engages with a socket E connected with the jaws by means of links. Longitudinal movement of the rod A is prevented by a set-screw F projecting into a groove H.
Patent GB-189709514-A (GB)
Title: Improvements in Golf Clubs.
Inventor: BREWSTER FRANCIS WENTWORTH
Filed: 1897-04-14
Granted: 1898-03-19
Abstract: 9514. Brewster, F. W. April 14. Golf.-The head A of a golf club is formed boat - like in plan, converging slightly towards the face a<1> (which is inclined more or less as required) and very considerably towards the rear a<2>. The top and bottom surfaces a<4>, a<5> are curved longi tudinally, the bottom having a portion a<6> considerably inclined at the rear, while its surface is either flat or slightly hollow in cross-section. If made of wood, the head is provided with a metallic sole c and face plate c<1>. The latter may extend any desired height up the face. Or a thin metal band may pass completely around the head. The head is bored with an inclined hole a<9>, through which the lower thinned and rounded end b<1> of the shaft is passed, a shoulder b<3> on the latter seating upon an enlarged opening in the head, while an inclined pin d, passing through the head and the lower end b<1> of the shaft, secures the shaft in position. The shaft B narrows above the shoulder, and its upper gripping end is formed elliptical in section, the portions for the two hands being at an angle to one another.
Patent GB-189710525-A (GB)
Title: Improvements in Skewers.
Inventor: SHIPE WALTER SCOTT
Filed: 1897-04-27
Granted: 1897-05-29
Abstract: 10,525. Shipe, W. S. April 27. Skewers are formed with flattened points and with projecting sharp-edged ribs. The head is flared. Fig. 1 shows a general view, Figs. 1<a>, 1<b>, 1<c>, and 1<e> sections, and Fig. 1<d> the head. I n modifications, the ribs A<3> may be dispensed with.
Patent GB-189711719-A (GB)
Title: Improvements in Sphygmo-manometers.
Inventor: HILL LEONARD ERSKINE
Filed: 1897-05-11
Granted: 1898-03-26
Abstract: 11,719. Hill, L. E., Barnard, H. L., and Hicks, J. J. May 11. Sphygomometers.-An instrument for indicating on a scale the blood pressure in the arteries, and the pulsations thereof, consists of a clasp or armlet a, having on its inside a flexible air bag b, connected by means of a tube c with an air pump d for inflating it, and with a manometer h, similar in construction to an ordinary aneroid barometer, the pointer g of which indicates the fluctuations of pressure.
Patent GB-189712909-A (GB)
Title: Improvements in Vehicle-springs.
Inventor: MOORE SETH MARION
Filed: 1897-05-25
Granted: 1897-07-10
Abstract: 12,909. Moore, S. M., and Larsh, D. L. May 25. Springs, bearing, for buggies, carts, and other vehicles. The body of the vehicle is mounted on a cross-bar 2 attached to a curved leaf spring 1 which is hinged at its ends to two bars 5. The inner ends of the bars are hinged together at 6, and are connected by a coiled spring 9 to the centre of the leaf spring. The outer ends of the bars are provided with loops 7 for attachment to the side bars of the running-gear &c. The body of the vehicle is thus maintained at the same level on each side, even when it is loaded more heavily on one side than on the other.
Patent GB-189718947-A (GB)
Title: Improvements in Paper Cop Tubes, Cones, or Spools, and in the Mode and Machinery for Making the same.
Inventor: SWAILES JOSEPH BRIGGS
Filed: 1897-08-16
Granted: 1898-06-18
Abstract: 18,947. Swailes, J. B., Swailes, G., and Swailes, J. B. Aug. 16. Paper tubes.-Relates to cop tubes. The strip x from which the tube is made is cut by blades e, e<1> from a strip x<1>, and is presented to a rotating mandrel c. During the operation of winding, on the mandrel, it is acted on by a corrugated roller i, which takes the place of the ordinary smooth presser roller and corrugates the tube as it is being made and while still wet with the adhesive material. The ends of the roller are plain and lie above the level of the corrugations so as to produce a tube with plain ends. The spindle on which it runs is barrelshaped, while the hole through the roller is cylindrical, and the roller thus has some play in its spindle. It is held up to its work by a spring h<3>, and is disengaged at the end of the operation by a cam g<1> to allow the tube to be stripped from the mandrel. A machine is also shown with a plain fixed presser in addition to a corrugating-roller, which is rotated by a wheel with teeth extending only partially round it, so that the motion of the roller is arrested at the right moment. Means for making taper tubes on a stepped mandrel are also shown.
Patent GB-189725769-A (GB)
Title: Improvements in or relating to Apparatus for Volatilising or Vapourising Fluids.
Inventor: BOULT ALFRED JULIUS
Filed: 1897-11-05
Granted: 1898-10-01
Abstract: 25,769. Boult, A. J., [Malapert, D. de]. Nov. 5. Vapour engines. - Consists of apparatus for vaporizing fluids, particularly suitable for volatilizing ether, in which means are provided for regulating the generation of vapour and preventing excessive rise of pressure. The substance to be vaporized is introduced into a vessel A surrounded by a water or other jacket D for maintaining it at a low temperature. Thence it passes into the tubes F surrounded by heated air or other heating-agent. The vapour collects in the drum M round which the heating - agent first circulates. When the pressures rises excessively the substance is in part forced back into the vessel A, and the pressure is communicated to a spring - pressed diaphragm therein. By the movement of this the lamp N, or other source of heat, is through suitable connections appropriately regulated.
Patent GB-189800217-A (GB)
Title: Improvements in Grinding and Dressing Machines, chiefly designed for Finishing the Cups or Boxes for Cycle Ball Bearings.
Inventor: HARPER LEWIS EDWARD
Filed: 1898-01-04
Granted: 1898-08-27
Abstract: 217. Harper, L. E., and Dow, R. F. Jan. 4. Milling.-Relates to a machine for surfacing and polishing the insides of the cups of bicycle ball bearings and other work of irregular form. The article C' is secured in a suitably mounted and driven chuck C, Fig. 16. The grinding, milling, or other tool G, together with a driving-pulley D, is mounted upon a spindle 30, supported in bearings on the table T. This rests upon the upper member of a compound slide-rest 5,6 which is adjustable upon a table 9, also adjustable upon the bed of the machine. A plate 56 secured to the underside of the table T works in guide-ways in a plate 55 which again is guided in the slide 6 and is formed with a rectangular opening through which and through a guide or former 75, Fig. 18, a pin 70 on the table passes into a radial slot in an oscillating wheel D'. The pulley 97 has on its spindle a worm in gear with a wheel 87 which carries an adjustable crank-pin 88 engaging with a slide 84 ; this has secured to it a rack in gear with teeth on the wheel D<1>, the oscillation of which causes the tool to move to and fro in the required path. The tool is pressed up to the work by a spring behind the pin 70 in the wheel D'.
Patent GB-189805039-A (GB)
Title: Improvements in Perpetual Calendars.
Inventor: DREYFUS GEORGE
Filed: 1898-03-01
Granted: 1898-04-09
Abstract: 5039. Dreyfus, G. March 1. Calendars.-The object is to reduce the number of superposed interchangeable cards as much as possible. The Figures show one form, which may, be variously modified. The days of the week are printed at the top and bottom edges (on both sides) of two cards A ; the days of the month on all the edges of four square cards B ; the names of the months on top and bottom edges of three cards C. In addition, four cards D may be employed giving the various possible arrangements of the days of the month with respect to the weekdays.
Patent GB-189805862-A (GB)
Title: Belting Cigarettes with Cork over a Backing or between Lines of Gold Silver, Aluminium, or Bronze.
Inventor: SEDDON FRANK MARLAND
Filed: 1898-03-10
Granted: 1899-01-21
Abstract: 5862. Seddon, F. M. March 10. Cigarettes.-Cigarette papers are printed at one end with a broad band of gold, silver, aluminium, or bronze, and after or before the cigarette is made a somewhat narrower band of cork is fixed to the paper by an adhesive so as to show a gold &c. border on each side. Two narrow bands of gold &c. at the proper distance apart will produce the same effect as a broad one.
Patent GB-189807470-A (GB)
Title: Improvements in and Apparatus for Effecting Electrolysis.
Filed: 1898-03-28
Granted: 1899-02-18
Abstract: 7470. Wise, W. L., [Solvay & Co.]. March 28. Drawings to Specification. Chlorine is obtained by the electrolysis of an alkaline chloride, using a mercury cathode. The essential feature consists in continuously circulating the mercury, entering at the lowest part of the cell, and overflowing from the other end over an adjustable weir.
Patent GB-189809833-A (GB)
Title: Cycle Stand.
Inventor: TAYLOR PETER
Filed: 1898-04-29
Granted: 1899-04-29
Abstract: 9833. Taylor, P. April 29. Locks, key.-Relates to a coin-freed stand for holding cycles. The stand may be constructed to receive several cycles. Fig. 1 represents the upper part of a stand for two cycles, the left-hand part being shown with the cover removed. The head &c. of the cycle is placed at W between jaws 0, A, the former being fixed, while the latter is carried by a sliding bolt A' passing horizontally through the case a, b and locked in extreme positions by a pin P carried by a spring lever R and engaging holes therein. A transverse spindle F carries within the case arms J, M, the former acting on projections L, K on the bolt, and the latter serving as a stop for the coin. The spindle F carries in front of the case a sector G fitted with a handle f which acts as a counterweight. The case is provided with a coin slit C and a keyhole. Fig. 1 shows the apparatus with the jaws open, the sector then covering the keyhole. When it is desired to lock a bicycle in the stand, a penny is placed in the slit, falls into a receiver N, and depresses the lever R, thus freeing the pin P from the bolt A. The handle f is then allowed to fall, or is pushed down, and rotates the spindle F, causing the arm J to bear on the projection K and shoot the bolt. The arm M allows the penny to fall, and a spring returns the lever so that the pin P locks the bolt A<1>. The sector G is now clear of the keyhole, so that the key can be removed and the slot is covered. To release the cycle, the key, Fig. 2, is inserted and given a quarter turn so as to depress the pin P. The sector is then turned so that the bolt is withdrawn and the key is turned back by a groove H coming in contact with its handle. The pin P is raised and the apparatus is locked in the open position, the key being covered by the sector. A box Z, with a hinged lid, is arranged above the stand to receive accessories and cover the lamp on the machine.
Patent GB-189810763-A (GB)
Title: Treating Calcium Carbide for use in Acetylene Generators.
Inventor: SARTIG JOHANNES
Filed: 1898-05-11
Granted: 1898-06-18
Abstract: 10,763. Sartig, J. May 11. Calcium carbide.-Calcium carbide is mixed, or treated in any manner, with a small amount, say from 3 to 6 per cent., of talc, lycopodium, or other similar material unaffected by the water or the gas in acetylene generators, which will enable the carbide to slip or slide easily when being charged into the generator.
Patent GB-189811430-A (GB)
Title: Improvements in Attachments for Corsets.
Inventor: WARDROPER ANNIE
Filed: 1898-05-19
Granted: 1898-07-02
Abstract: 11,430. Wardroper, A. May 19. Corsets; belts.- Corsets are provided at their lower end with an abdominal belt a to aid in drawing in the figure. The belt is attached to t h e corset in the rear by safety pins, is in two or more parts laced or otherwise fastened together, and is stiffened at intervals by bones e.
Patent GB-189813587-A (GB)
Title: Improvements in Screw Propellers.
Inventor: ASHBURY EDWARD ATKINS
Filed: 1898-06-18
Granted: 1899-06-17
Abstract: 13,587. Ashbury, E. A., and Whitmore, T. June 18. Screw propellers.-Two or more helical blades are formed on a hollow or solid conical boss E. These increase in diameter from the apex to the base.
Patent GB-189815907-A (GB)
Title: Improvements in the Manufacture of Acetone.
Inventor: HAWLICZEK JOSEF LUDWIG
Filed: 1898-07-21
Granted: 1899-07-15
Abstract: 15,907. Hawliczek, J. L. July 21. Retort furnaces.-Relates to retort furnaces used in the manufacture of acetone directly from wood, sawdust, or the like and an alkaline earth or the like. The Figure shows a retort chamber in which are mounted pairs of inclined retorts a connected by a bifurcated neck b fitted with a charging-door b<1>. The retorts are heated by gases which pass from the chamber c through openings c', flues d, spaces f<1>, and checkered brickwork floors f into the chambers e. These chambers are enclosed by removable outer walls g mounted between girders k and the ends of the lining plates g<1>. The girders k support the roof l. The vapours produced pass by pipes o into a main p and thence to the condensers. The charcoal remaining in the retorts is discharged by gravity upon opening the doors a', which are outside the retort supports.
Patent GB-189818447-A (GB)
Title: A Device for Retaining Flowers in Button Holes.
Inventor: MABEY FREDERICK OSCAR
Filed: 1898-08-27
Granted: 1899-07-15
Abstract: 18,447. Mabey, F. O. Aug. 27. Flower holders, buttonhole.-The base-plate A is secured by sewing &c. to the back of a coat lappel or elsewhere at a suitable distance from the buttonhole. The stem of the flower is held by the spring tongue B, which is curved to enable the stem to be passed between it and the base-plate.