baber/WOPTO huggingface dataset:
Patent EP-1504098-A2 (EP)
Inventor: FUREBRING CHRISTINA
IPC: A61K48/00
Filed: 2003-05-16
Abstract: A method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single-stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing a first population of single-stranded polynucleotide molecules and a second population of single-stranded polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) carrying out a reaction for digesting the first and second populations of single-stranded polynucleotide molecules with an exonuclease to generate corresponding populations of single-stranded polynucleotide fragments, (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3' and 5'ends of at least one of the parent polynucleotides under annealing conditions, and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides, wherein, in step (b), at least one parameter of the reaction used for digestion of the first population of single-stranded polynucleotide molecules is different from the equivalent parameter(s) used in the reaction for digestion of the second population of single-stranded polynucleotide molecules. Preferably, the reaction parameter is selected from exonuclease type, exonuclease concentration, reaction volume, duration of the digestion reaction, temperature of the reaction mixture, pH of the reaction mixture, length of parent single-stranded polynucleotide sequences, amount of single-stranded polynucleotide molecules and buffer composition of the reaction mixture.
Patent EP-1489928-A2 (EP)
Inventor: SNAIDR STANISLAV M
IPC: D21H27/00
Filed: 2003-03-14
Abstract: Une cigarette à fumée secondaire faible, selon l'invention, comprend une tige de tabac classique et un papier de traitement combustible présentant une composition de traitement de fumée secondaire. Ladite composition de traitement comprend un catalyseur d'oxydation d'oxydes métalliques de stockage et donneur d'oxygène combiné à un adjuvant particulaire sensiblement non combustible destiné audit catalyseur. Selon l'invention, des améliorations sont apportées à la composition de traitement et/ou à l'addition d'oxydes métalliques ou de carbonates afin d'améliorer les caractéristiques des cendres.
Patent EP-1497428-A2 (EP)
Inventor: UHLER MICHAEL D
IPC: C12N15/09
Filed: 2003-04-16
Abstract: The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which transfect the cells. Preferably, the nucleic acids are immobilized in an array. In another aspect of the present invention, the method further includes expression of the nucleic acids in the transfected cells. In yet another aspect of the present invention, the method further comprises detecting the expression of the nucleic acids in the transfected cells.
Patent EP-1546138-A2 (EP)
Inventor: KARUP GUNNAR LEO
IPC: C07D333/56
Filed: 2003-09-30
Abstract: Raloxifene sulphuric acid addition salts or solvates thereof, having improved dissolution properties in media comprising hydrochloric acid are described, compared with similar preparations based on raloxifene or raloxifene hydrochloride. The disclosed sulphuric acid addition salts or solvates thereof show an improved bioavailability in media comprising hydrochloric acid, such as the gastric juice. Further, crystalline forms of the raloxifene salts and solvates thereof are disclosed.  The raloxifene sulphuric acid addition salts and/or solvates thereof are useful for the preparation of pharmaceutical composition for oral administration capable of fast and reliable release of the active ingredients in the stomach of the patient, in particular for the treatment of cancer or osteoporosis, or for inhibiting cartilage degradation.
Patent EP-1545610-A2 (EP)
Inventor: SIMARD JOHN J L
IPC: C12N5/0786
Filed: 2003-09-05
Abstract: La présente invention a trait à des polypeptides, comprenant des site antigéniques, des agrégats, et des antigènes. L'invention a également trait à des compositions comportant lesdits polypeptides et des procédés pour leur utilisation.
Patent EP-1543167-A2 (EP)
Inventor: PARK JONG-GU
IPC: C12Q1/68
Filed: 2003-07-25
Abstract: Cette invention concerne de grandes molécules sens circulaires disposées dans un réseau. Ce réseau de grandes molécules sens circulaires est combiné à une hybridation d'ADNc pour que les différences dans le profil d'expression entre différentes cellules soient détectées. Les grandes molécules sens circulaires ont été purifiées de clones non redondants à l'aide de phagémide de recombinaison et disposées en réseau sur des lamelles de verre silanisées. L'hybridation du réseau de grandes molécules sens circulaires à l'aide de préparations d'ADNc marquées Cy3 ou Cy5 à 60 °C a permis de détecter 29 gènes régulés positivement et 6 gènes régulés négativement dans des tissus hépatiques cancéreux.
Patent EP-1556250-A2 (EP)
Title: Accessoire pour vehicule a moteur
Inventor: LOCK RICHARD STEVEN
IPC: B60B7/20
Filed: 2003-07-09
Abstract: La présente invention concerne un ensemble enjoliveur comprenant une unité enjoliveur (10) montée rotative sur une unité de fixation (20) au moyen d'une fusée (12), qui s'emboîte dans une unité de support (24, 25, 26, et 27) dans l'unité de fixation.  Un poids (13) est attaché décentré sur l'unité enjoliveur, de façon que l'unité enjoliveur ne tourne pas avec la roue du véhicule.  L'unité de fixation comprend une monture (21) comportant une ou plusieurs pattes coudées (22) percées de trous (23) à leur extrémité, que l'on attache à la roue du véhicule en dévissant les écrous de roue, en plaçant l'unité de fixation par-dessus les boulons de roue, et en replaçant les écrous de roue.  L'unité enjoliveur peut comprendre une paire de coupelles avec un motif intercalé, la coupelle extérieure étant transparente.
Patent EP-1539478-A2 (EP)
Title: Feuille imprimable a plusieurs configurations possibles utilisee pour constituer des jaquettes et des livrets a inserer dans des boitiers
Inventor: MCCARTHY BRIAN
IPC: B42F5/00
Filed: 2003-07-28
Abstract: Selon l'invention, une feuille unique présente plusieurs lignes de séparation de sorte que la feuille peut être imprimée par une imprimante standard telle que celle d'un ordinateur personnel, puis être séparée et/ou pliée en l'une quelconque de trois configurations différentes pour former différentes jaquettes à insérer dans des boîtiers de disques compacts, qui comportent à la fois des parties frontales et des parties latérales. Un mode de réalisation concerne une feuille qui présente au moins quatre lignes de fragilité longitudinales qui s'étendent sur au moins une partie principale de la longueur de la feuille, et au moins trois lignes de fragilité transversales qui s'étendent sur une partie principale de la largeur de la feuille, au moins une ligne de fragilité longitudinale étant une ligne de pliure le long de laquelle au moins une partie est repliée.
Patent EP-1571970-A2 (EP)
Inventor: BAR-OR DAVID
IPC: A61K38/00
Filed: 2003-10-02
Abstract: The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer's disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention.
Patent EP-1556627-A2 (EP)
Inventor: OHARA YASUYUKI
IPC: E06B9/17
Filed: 2003-10-30
Abstract: L'invention concerne un élément amortisseur se plaçant entre chaque cadre support et le côté correspondant d'un store. L'élément amortisseur comprend deux éléments de base en forme de bande, et des fils de velours formant un pont entre les éléments de base. Certains fils de velours, coupés à une partie intermédiaire, entre les éléments de base, forment des premiers et des deuxièmes fils de velours coupés opposés qui comportent une coupure entre ceux-ci. On fixe un des éléments de base à chaque cadre support, l'autre élément de base touchant le store. La coupure permet à l'élément amortisseur de répondre de manière flexible aux mouvements du store et d'assurer une fonction d'amortissement satisfaisante afin de supprimer tout battement du store.
Patent EP-1565932-A2 (EP)
Title: Procede de production et de verification d'un canal resistant a la corrosion dans un dispositif en silicium
Inventor: HARRIS JAMES M
IPC: B81B7/00
Filed: 2003-11-17
Abstract: L'invention concerne un procédé de production d'un canal résistant à la corrosion dans une voie humide d'un dispositif en silicium, ledit procédé permettant à ce dispositif d'être utilisé avec des composés corrosifs tels que le fluor. Une voie humide d'un dispositif MEMS est recouverte soit (1) d'un composé organique résistant à une attaque par du fluor atomique, soit (2) d'une matière pouvant subir une passivation par du fluor atomique. Le dispositif est ensuite exposé à un gaz qui se décompose en composés de fluor actif lorsqu'il est activé par une décharge de plasma. Ce gaz peut être par exemple du CF4, qui est un gaz inerte qui est plus facile et plus sûr à mettre en oeuvre que des gaz volatils du type ClF3. Ce gaz permet d'effectuer une passivation de la matière (le cas échéant) et il corrode tout silicium exposé. Le dispositif est vérifié de manière que toute corrosion inacceptable de la voie humide entraîne une défaillance du dispositif. Si le dispositif fonctionne correctement, la voie humide est estimée être résistante à la corrosion par le fluor ou d'autres composés corrosifs suivant le cas.
Patent EP-1532753-A2 (EP)
Inventor: JIANG JAMES
IPC: H04W4/00
Filed: 2003-08-07
Abstract: Procédés et systèmes de mise en application de techniques de raccordement dans des systèmes AMRC pour traiter des appels de groupe et des services de conversation.
Patent EP-1584024-A2 (EP)
Inventor: HENSLEY JOHN ALAN
IPC: G06F11/14
Filed: 2003-12-02
Abstract: An emergency boot directory, containing a back-up copy of a primary operating system, is maintained in a protected, hidden subdirectory hierarchy during normal computer operations. A bootable media, which may be a removable media, contains bootstrap code operative to load and run the back-up operating system, if the primary operating system fails to boot and run. A file system filter driver hides and protects the emergency boot directory by intercepting file or data access and directory entry enumeration requests. The filter fails access requests directed to the emergency boot directory, and edits the results of enumeration requests to remove references to the emergency boot directory. The protected, hidden emergency boot directory can be located and maintained within an existing main storage area and does not depend on hidden attributes of secondary storage areas such as separate disk partitions or file systems.
Patent EP-1576180-A2 (EP)
Inventor: APFELD JAVIER
IPC: C12Q/
Filed: 2003-12-04
Abstract: Control of AMPK activity enables interventions that modulate lifespan regulation. Agents which alter lifespan regulation of a cell or organism are identified by screening for compounds that regulate AMPK activity or AMPK pathway activity. The agents so-identified and compounds known to alter AMPK pathway activity can be administered to a subject, e.g., to alter lifespan regulation in the subject or to affect a longevity-associated disorder, or a risk, symptom, predisposition thereof.
Patent EP-1450082-A2 (EP)
Inventor: STOFFERS CHRISTIAN
IPC: G05D16/10
Filed: 2004-01-31
Abstract: Pressure-limiting valve for a fluid medium under system pressure comprises a valve housing (1) provided with an inlet channel (3) and an outlet channel (4). The medium flow is controlled by an axially displaceable valve body (5) interacting with a force accumulator (2) and cooperating with a valve seat (6). A piston (7) coaxially connected to the valve body defines a throttle gap on the casing side, which is connected to the inlet channel and is loaded directly or indirectly with pressure via the force accumulator. Preferred Features: The piston is surrounded on the casing side by a fixed sealing sleeve (8). The piston and the sealing sleeve are made of a wear-resistant material, preferably hard metal.
Patent EP-1478057-A2 (EP)
Inventor: GIRARDELLO LORENZO
IPC: H01R33/76
Filed: 2004-05-13
Abstract: The device has a plug device (120) with a conducting contact pin (122) and an insulating sleeve (123) enclosing it at a defined lateral distance and a bush device (110) with a conducting contact bush (112) for receiving the contact pin and a second insulating sleeve enclosing the bush at a second lateral distance. The first insulating sleeve accommodates the second sleeve with the plug connector in the connected state.
Patent EP-1482557-A2 (EP)
Inventor: MORI MITSUYOSHI
IPC: H01L27/146
Filed: 2004-05-28
Abstract: A read-out pulse line for supplying a signal for switching is provided in common
for transfer gates provided for each of ones of photoelectric diode (PD) sections located in
a pair of adjacent rows. The transfer gates are switched by the read-out pulse line, charges
of the ones of PD sections are transferred to different floating diffusion (FD) sections, and
created charges are detected by each pixel amplifier provided so as to correspond to each
of the FD sections. Thus, pixel signals of a pair of rows can be obtained simultaneously on
output signal lines.
Patent EP-1491388-A2 (EP)
Inventor: MORIYAMA GENTA
IPC: B60N2/22
Filed: 2004-06-23
Abstract: A seat apparatus (1) comprising a seat back (2) as a backrest portion, a seat cushion (3) as a seating portion, a link mechanism (4) for supporting the seat cushion on a vehicle floor, and a driving source (61) for actuating the link mechanism (4) to position the seat cushion (3) between a seating position and a stored position,  characterized in that  the link mechanism (4) is pivotally mounted on the vehicle floor for defining a posture thereof.
Patent EP-1517066-A2 (EP)
Inventor: SAKAMOTO HIROSHI
IPC: B60W10/11
Filed: 2004-09-15
Abstract: A control system for a motor vehicle is provided which is capable of reducing a load
on a friction engagement device and preventing the friction engagement device from being
damaged. A transmission (50) includes a plurality of gears and a plurality of dog clutches for
transmitting torque from an input shaft (41) to an output shaft (42) and a friction engagement
device (10). A torque transmission path from the input shaft (41) to the output shaft (42) is
formed through engagement between the gear and the dog clutch. When the engagement
between the gear and the dog clutch is changed from a first engagement to a second
engagement, the friction engagement device (10) is used to transmit torque of an engine (6)
from the input shaft (41) to the output shaft (42). A power train unit (100) includes state
determiner (310) and engine torque control means (320). The state determiner (310) detects
or estimates a thermal state of the friction engagement device (10). The engine torque
controller (320) controls the torque of the engine (6) according to a parameter representing
the thermal state detected or estimated by the state determiner (310).
Patent EP-1486958-A2 (EP)
Inventor: MURAMATSU EIJI
IPC: G11B7/135
Filed: 1999-10-21
Abstract: A recording medium, comprising gooves (1), lands (2) formed between
the respective gooves (1), and land prepits (3) formed on the respective
lands (2), wherein each of the land prepits (3) is formed so that a
ratio between a voltage amplitude of a land prepit detection signal and
an offset level of an RF signal is maximized. An optical system is
provided comprising an objective which is
adapted to form a light spot on a respective goove, the light spot having a
diameter larger than the width of the groove, a photodetector which is
adapted to receive light reflected from the recording medium and adapted
to generate a photodetection signal; and an operation circuit which is
adapted to generate the land prepit detection signal and the RF signal
based on the photodetection signal.
Patent EP-1529974-A2 (EP)
Inventor: TAYLOR BRIAN LEE
IPC: F16C33/38
Filed: 2004-10-06
Abstract: A post bearing (10) and method of manufacture in which bearing balls (14) are loaded into
a series of pocket holes (16) arranged along a helical pattern in a sleeve cage (12). A single groove (26) is
swaged into the outside diameter of the sleeve intermediate the ball turns to capture the balls in
the pocket holes.
Patent EP-1544476-A2 (EP)
Inventor: KUCHER TRENT S
IPC: F15B15/28
Filed: 2004-10-15
Abstract: A method and apparatus for determining the position of a rod
member (26) of a cylinder assembly (10) are provided. The cylinder assembly
(10) may include a cylinder body (14), a gland member (18), a sensor mount (22),
a rod member (26), and a position sensor (30) attached to the sensor mount. The
cylinder body (14) may have a first mounting portion disposed thereon. The
gland member (18) may be disposed within a gland opening (38) of the cylinder
body (14). The sensor mount (22) may have a second mounting portion (146)
disposed thereon and may be attached to the cylinder body (14) via a coupling
engagement between the second mounting portion (146) of the sensor mount (22)
and the first mounting portion (50) of the cylinder body (14). The rod member
(26) may be slidably arranged within rod openings of the sensor mount (22) and
the gland member (18) and may extend into a longitudinal cylinder chamber (34)
of the cylinder body (14).
Patent EP-1571158-A2 (EP)
Inventor: KRAFT GRANT A
IPC: G01Q60/24
Filed: 2000-08-04
Abstract: The invention provides amyloid beta-derived dementing ligands (ADDLs) that
comprise amyloid β protein assembly bled into globular non-fibrillar oligomeric
structures capable of activating specific cellular processes. The invention
provides methods for assaying the formation, presence, receptor protein binding
and cellular activity of ADDLs, as well as compounds that block the formation
or activity of ADDLs, and methods of identifying such compounds. The
invention further provides methods of using ADDLs, and modulating ADDL
formation and/or activity,  inter alia  in the treatment of learning and/or memory
disorders.
Patent EP-1548245-A2 (EP)
Inventor: BIEN WILFRIED
IPC: F01N13/10
Filed: 2004-11-24
Abstract: The exhaust manifold (1) to connect an exhaust system to at least one cylinder of an internal combustion engine has at least one split manifold section (3,9,17) assembled from at least two moulded shells (4,14,10,20,18,28) joined together by a mechanical form closure. The manifold is provided with at least one inlet (5,11,19), whereby each split manifold is constructed so that the inlet opens into the cylinder. Each split manifold section is fastened by a flange (23) installed on the cylinder. An independent claim is included for a split manifold section as at least one component of an exhaust manifold.
Patent EP-1472966-A2 (EP)
Inventor: DE KUYPER EWIT
IPC: A47L15/16
Filed: 2004-05-01
Abstract: Machine dish washing process is invented wherein a detergent
is supplied from a storage supply (13) and is dispersed from at
least one nozzle (16) over crockery within the dish washing machine (1)
such that said crockery is washed with said detergent and said
detergent is removed from said crockery thereafter, wherein
said detergent is dispersed in a pulsating manner, e.g. said
detergent leaves the nozzle (16) as a pulsating flow. Preferably
said pulse frequency is below 15 Hz, and during a single
pulsating cycle, the dispensing rate changes e.g. from zero to
maximum and back to zero.
Patent EP-1566911-A2 (EP)
Inventor: MILLS DIANE G
IPC: H04L1/00
Filed: 2004-12-23
Abstract: Described herein is a reduced complexity Turbo multi-user detector
(MUD) processing system for use in multiple access communications channels
that decreases the likelihood of improper decoding of the final values of interest
and decreases the computation complexity for each iteration. The processing
system allows for a reduction in the number of iterations performed and lowers
the overall complexity without negatively impacting performance. In one form
the present invention comprises a multi-user detector coupled to two or more
decoder sections, two ore more recoders, and a compare and adjust section in
such a manner that data flows iteratively to correct for errors in a
computationally efficient manner.
Patent EP-1463030-A2 (EP)
Inventor: ITO TSUGIO
IPC: G10K15/12
Filed: 2004-03-22
Abstract: A reverberation apparatus is designed for generating
a reverberation sound from an input sound with use of an
impulse response based on an instruction. In the
reverberation apparatus, a first storage section stores
first impulse response data representative of a first
impulse response. A second storage section stores second
impulse response data representative of a second impulse
response which is different from the first impulse response
represented by the first impulse response data. A new data
creating section operates based on the first impulse
response data and the second impulse response data for
creating new impulse response data representative of a new
impulse response in accordance with the instruction. A
reverberation sound generating section generates
reverberation sound data representative of the
reverberation sound by filtering input sound data
representative of the input sound with use of the new
impulse response data, such that the generated
reverberation sound is featured by the new impulse
response.
Patent EP-1480085-A2 (EP)
Inventor: PATEL NITAL
IPC: H01L21/027
Filed: 2004-05-21
Abstract: The present invention provides a method for determining
resist trim times in an etch process. In one embodiment of the
invention, the method for determining resist trim times includes
obtaining resist profile data and critical dimension (CD) data
of a patterned resist layer using a scatterometer, in a step
520, and then obtaining an estimated trim time of the patterned
resist layer using the resist profile data and critical
dimension data, in steps 530-550.
Patent EP-1482431-A2 (EP)
Inventor: CUSHING DAVID
IPC: G06F17/30
Filed: 2004-05-27
Abstract: A multidimensional query results processing system for translating output of an
execution of a multidimensional query into a data result set that reflects the semantics of
an entity/relationship schema report specification is provided. The system comprises a
result set description generation module for producing a result set description that reflects
the semantics of the report specification, a tabular row generation module for converting
the results of the single multi-dimensional query into a collection of rows of data, a
tabular summary level calculation module for calculating a summarization level of a row
a data, a tabular header row generation module for producing a header row to include in
the row of data, and a cross-tabulated result generation module for convening the results
of the single multi-dimensional query into a result set that matches the semantics of the
report specification.