baber/WOPTO huggingface dataset:
Patent CA-2244412-A1 (CA)
Inventor: FRASER PAUL E
IPC: C12Q1/00
Filed: 1997-01-27
Abstract: The present invention describes the identification, isolation, sequencing and characterization of several human genes which interact with the presenilins, mutations in which may lead to Familial Alzheimer's Disease. These presenilin-interacting protein genes may be involved in the pathways which, when affected by mutant presenilins, lead to the development of Alzheimer's Disease. In addition, mutations in the presenilin-interacting protein genes, even in the absence of defects in the presenilins, may be causative of Alzheimer's Disease. Nucleic acids and proteins comprising or derived from the presenilin-interacting proteins are useful in screening and diagnosing Alzheimer's Disease, in identifying and developing therapeutics for treatment of Alzheimer's Disease, and in producing cell lines and transgenic animals useful as models of Alzheimer's Disease.
Patent CA-2248385-A1 (CA)
Inventor: JAEGGI DOMINIK
IPC: H01L23/31
Filed: 1998-09-25
Abstract: The  present  invention  concerns  a  structure  (21) formed on a substrate (23) formed of a substrate material intended to be etched by a reactive agent,  this structure including  at  least  one  first  outer  layer   (29), or passivating layer,  which has  a  first  elastic  property. This structure further includes at least one second outer layer  (33)  formed above  the  first layer,  so  that  the second  layer  has  a  second  elastic  property  which  is different to the first elastic property. In the event that the second elastic property provides the second layer with greater elasticity in compression than the  first  layer, said  structure has  advantageously  a  yield  higher  than 99.8%.
Patent CA-2251810-A1 (CA)
Title: Sequesterants as hypochlorite bleach enhancers
Inventor: SMITH WILLIAM L
IPC: C11D7/54
Filed: 1997-05-01
Abstract: Sequestering agents for use as a whitening and fabric strength enhancer for aqueous hypochlorite bleach compositions are provided. It was found that the sequesterants when used with hypochlorite in the presence of soluble heavy metal ions, particularly iron and manganese ions, provide significantly improved whitening and fabric protection. Most preferably, the sequesterants are selected from polyacrylic acid, a polyacrylic acid derivative, a copolymer of acrylic acid or methacrylic acid and a comonomer which is maleic acid or maleic anhydride and mixtures thereof. In one aspect, the sequesterants are employed in a method for laundering fabrics comprising: a) providing, in a wash liquor containing (i) at least about 40 ppb of iron cations or (ii) at least about 10 ppb of manganese cations, or (iii) the cations of both (i) and (ii), and a fabric piece; and b) adding either prior to, contemporaneously with, or after, the step of providing of said fabric piece to said wash liquor a hypochlorite composition which comprises one or more of said sequesterants. Preferably the sequesterant comprises at least 0.1 ppm by weight of said wash liquor and the hypochlorite composition is an alkali metal hypochlorite and said sequesterant has a molecular weight of between about 500 and 500,000 daltons.
Patent CA-2252828-A1 (CA)
Title: Alkoxy acetic acid derivatives
Inventor: KENDALL DAVID ROY
IPC: C10L1/182
Filed: 1997-04-25
Abstract: This invention provides alkoxy acetic acid derivatives of general formula (I) wherein R is the residue of an amine, an aminoalcohol or a polyol linked to the or each -CHR'-CO- moiety via an amide or ester linkage; R' is hydrogen or a C1-4 alkyl group; R1 is an optionally substituted hydrocarbyl group of 1 to 300 carbon atoms; one of R2 and R3 is independently selected from hydrogen and optionally substituted hydrocarbyl of 1 to 10 carbon atoms, the other of R2 and R3 being independently selected from optionally substituted hydrocarbyl of 1 to 10 carbon atoms; m is from 3 to 200; n is from 0 to 20, provided that m/n is at least 1; and p is from 1 to 5; a process for their preparation; and their incorporation in additive concentrates and fuel compositions for internal combustion engines. Derivatives of formula (I) give rise to advantageous engine cleanliness effects.
Patent CA-2255401-A1 (CA)
Title: Power operator for switchgear with manual features
Inventor: KERR TERRENCE S
IPC: H01H3/22
Filed: 1998-12-09
Abstract: A power operator for switchgear and the like is provided that is capable of either power or manual operation without the necessity of any decoupling or mode selection.  The power operator is compact and easily affixed over a manual operating shaft of switchgear. The manual drive capabilities are always coupled for operation without any backdriving of the power source. The power operator includes a drive output affixed to the switchgear operating shaft, a manual operating shaft, and an arrangement for selectively coupling a power-driven input to the switchgear operating shaft. In a specific arrangement, the control arrangement of the power operator senses the position of the drive output and also senses the current drawn by the drive source. When controlling switchgear having a stored energy mechanism, operating positions are detected by sensing the tripping of the stored energy mechanism via the sensed current through the drive source.
Patent CA-2256380-A1 (CA)
Title: Optical resolution of narwedine-type compounds
Inventor: JOHNSON NICHOLAS BERNARD
IPC: C07D491/10
Filed: 1997-05-23
Abstract: A process for the asymmetric transformation of a racemic compound of formula (I) wherein R1 is H or a alkyl group having up to 20 carbon atoms, R2 is H, or an alkyl, aryl, alkaryl or aralkyl group having up to 20 carbon atoms, and X is H, a halogen atom, tert-butyl, or any other removable substituent, comprises reaction of racemic compound (I) with an enantiomerically-enriched acid HY*, wherein Y* is a chiral group, to form a diastereomeric salt of compound (I) having Y* as a counterion. The salt obtained can then be reduced to give enantiomerically-enriched galanthamine, or a derivative thereof.
Patent CA-2257278-A1 (CA)
Title: Breathable stain resistant undergarment for use with an absorbent article
Inventor: LEE YANN-PER
IPC: A61F13/56
Filed: 1997-06-02
Abstract: An undergarment (20) for use with an absorbent article is described. The undergarment comprises a shell portion (30), a crotch portion (40) and elasticized leg openings (34) defined by the shell portion (30) and the crotch portion (40). The shell portion is breathable and preferably, liquid resistant. The crotch portion (40), which is elastically extensible in at least one of the longitudinal and the transverse directions, comprises an absorbent body layer and a liquid resistant barrier layer, and is preferably, breathable. The elasticized leg openings (34) cooperate with the elastically extensible crotch portion to provide a biasing force for an absorbent article against a wearer's body. A system for control of bodily fluids comprising an undergarment and an absorbent article is also described.
Patent CA-2257454-A1 (CA)
Inventor: DORBON MICHEL
IPC: C07C5/25
Filed: 1999-01-12
Abstract: On décrit un procédé pour l'obtention de 1-butène à partir de 2-butènes dans lequel: - une charge contenant au moins l'un des isomères du 2-butène est introduite par la ligne 1 dans une zone de distillation C; - l'effluent de fond de colonne est évacué de la zone de distillation par la ligne 2; - une partie du flux qui circule dans la ligne 2 est évacuée du dispositif par la ligne 7; l'autre partie du flux qui circule dans la ligne 2 étant réchauffée au moyen d'un échangeur de chaleur avant d'alimenter la ligne 4 d'adduction de la charge dans la zone d'hydro-isomérisation R; - la ligne 4 est aussi alimentée par la ligne 3 en un flux contenant au moins de l'hydrogène; - l'effluent d'hydro-isomérisation est évacué de la zone d'hydro-isomérisation R par la ligne 5, refroidi par un échangeur de chaleur, puis introduit à nouveau dans la zone de distillation C; - et l'effluent de tête de colonne de la zone de distillation est évacué par la ligne 6.
Patent CA-2257541-A1 (CA)
Title: Absorbent articles having an odour control system comprising a chelating agent
Inventor: GAGLIARDINI ALESSANDRO
IPC: A61F13/49
Filed: 1997-05-23
Abstract: The present invention relates to an absorbent article comprising an apertured polymeric film topsheet, a backsheet and an absorbent core. The absorbent articles further comprise an odour control system comprising a chelating agent. The combination of the chelating agent and the apertured polymeric film topsheet has been found to provide improved odour control.
Patent CA-2260034-A1 (CA)
Inventor: EASTMAN SIMON J
IPC: A61K47/48
Filed: 1997-07-11
Abstract: Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
Patent CA-2264934-A1 (CA)
Title: Producing laser light of different wavelengths
Inventor: WEBER JEAN-PIERRE
IPC: H04B10/43
Filed: 1997-09-02
Abstract: In a tunable laser device a plurality of basically identical lasers (3, 3') are arranged adjacent to each other in a line or row on a common substrate (1). The lasers (3, 3') can be DFB-type and they have different emission wavelengths, obtained from e.g. different pitches of gratings (5) which define the wavelengths of the respective lasers. The lasers can be activated to emit light independently of each other by supplying electrical current to contacts (11) located on the top sides of the lasers. When a laser is activated, the other lasers are biased, so that lasers located at one side of the active laser will be transparent to the emitted light, which can then travel from the lasers through an electrooptic modulator (17), and the lasers located at the other side will absorb the light. By controlling the temperature, the wavelength of emitted light can be finely adjusted. Such a laser device has a compact structure, is fairly insensitive to variations of the used drive currents and can in a simple way be adjusted to different operating conditions and be compensated for aging effects.
Patent CA-2265928-A1 (CA)
Inventor: KARANEWSKY DONALD S
IPC: A61P29/00
Filed: 1997-09-12
Abstract: This invention is directed to novel (N-substituted)indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
Patent CA-2266600-A1 (CA)
Inventor: FITZGERALD JOHN E
IPC: B65H57/04
Filed: 1998-07-31
Abstract: La présente invention concerne un guide-fibre (30) permettant d'enrouler sur une bobine (20) de la fibre de verre (13) provenant d'un bobinoir automatique. Ce guide (30) comporte un corps ou ensemble guide débiteur pourvu d'un orifice de réception. Deux parties semblables sont maintenues ensemble avec un léger intervalle entre elles. Des brins parallèles gauche et droit de la corde (38, 39), fermement étirés au travers l'intervalle en passant par l'orifice de réception de l'arc, sont ancrés à chaque extrémité. Une bobine (20) dont les bords forment des flasques, et qui reçoit les brins parallèles gauche et droit (38, 39) ou guides, est maintenue très proche de la première couche ou surface de fibres déposées. Une poulie de guidage est supportée par le guide (30) de façon à guider la fibre de verre sur la bobine (20) entre les brins parallèles gauche et droit (38, 39). La tension des brins parallèles (38, 39) est obtenue en les ancrant chacun (38, 39) dans une entretoise particulière (46). Les fils (38, 39) traversent les trous forés en croix, ce qui permet un réglage en faisant tourner l'entretoise (46). La plaque pivotante ressert les brins parallèles gauche et droit (38, 39) au moyen d'une force de ressort produite par un ressort (55) monté entre la plaque pivotante et le guide (30). Selon une autre réalisation, les brins parallèles gauche et droit (38, 39) sont écartés par des rondelles d'une épaisseur définie et agrafées.
Patent CA-2268202-A1 (CA)
Title: Miller cutterhead with two continuous rotations and direct drive
Inventor: SAEZ MARTINEZ JOSE IGNACIO
IPC: B23Q1/54
Filed: 1999-04-07
Abstract: Miller cutterhead with two continuous rotations and direct drive, of the kind that is comprised of slide, cutterhead and main spindle, where: a)-. the cutterhead is a modular element and has a first and second supplementary rotation spindle, to convert a three-spindle grinding centre or milling machine into a five spindle one; b)-. it has a first motor coupled directly onto the first supplementary rotation spindle with the stator fixed on the slide and with its motor fixed on the cutterhead; and c)-. it has a second motor coupled directly onto the second rotation spindle. The first and second motors are high torque flat motors with a low speed range; in particular direct servomotors, without any intermediate transmission or reduction.  Application in machine-tool.
Patent CA-2268666-A1 (CA)
Inventor: JOHANN JUERGEN
IPC: C02F1/461
Filed: 1997-10-08
Abstract: An aqueous solution with a tendency towards scaling is passed through an electrolysis chamber having at least two reversible electrodes (6) and a bipolar electrode (7). The polarity of the electrodes (6) is reversed at time intervals. An alternating current can be applied alternatively to the electrodes instead of a direct current with regular pole reversal of electrodes. This method of processing enables scaling to be reduced considerably or even prevented, and the salt content of the solution is substantially maintained. The method is especially suitable to reduce or prevent scaling from natural waters, without substantially impairing water quality.
Patent CA-2269211-A1 (CA)
Title: Compact scroll fluid device
Inventor: FORNI RONALD J
IPC: F01C1/02
Filed: 1997-10-23
Abstract: A compact scroll fluid device (2) includes a pair of wrap support elements (32, 61) with one of the wrap support elements (61) having an inner axial surface (65) formed with an involute spiral recess (79) and the other of the wrap support elements (32) having an involute spiral wrap member (44) projecting from an inner axial surface (36) thereof. The spiral wrap member (44) is received within the spiral recess (79) while being relatively movable about an orbital path therein. A synchronizer assembly (51) is provided axially between the wrap support elements (32, 61), radially inwardly of both inlet and outlet zones (81, 83) associated with the scroll fluid device (2) and radially outwardly of an orbit center (125) of the device (2). The entire scroll fluid device (2) is preferably made of plastic. With this arrangement, an extremely compact and inexpensive device (2) is provided.
Patent CA-2272073-A1 (CA)
Title: Utilisation locale de il-1ra pour le traitement des rejets de greffons corneens et d'autres troubles de l'oeil
Inventor: DANA M REZA
IPC: A61P37/06
Filed: 1997-11-19
Abstract: Cette invention concerne l'utilisation topique d'un antagoniste du récepteur de l'interleukine 1 (IL-1Ra) qui s'avère utile pour prolonger la vie d'un greffon cornéen dans un modèle murin d'allogreffe orthotopique, et notamment pour prolonger de manière significative la vie d'un greffon à la fois dans des stromas cornéens à haut risque et des stromas cornéens normaux (à risque faible). L'allongement de la durée de vie du greffon est par ailleurs associée à une diminution importante de l'inflammation de la cornée. Il est par conséquent possible d'utiliser IL-1ra, ainsi que les antagonistes de l'interleukine-1 associés, dans une composition thérapeutique destinée à la prophylaxie et au traitement topique du rejet des allogreffons et au traitement local d'une large gamme de troubles inflammatoires immunogéniques de l'oeil. Ladite composition contient une quantité thérapeutiquement efficace de IL-1ra associée à un excipient pharmaceutiquement acceptable pour l'application topique.
Patent CA-2273012-A1 (CA)
Inventor: COQUEREL GERARD
IPC: C07C215/08
Filed: 1997-11-28
Abstract: The invention concerns a method for splitting 1-amino-alkan-2-ol compounds of general formula (I) in which R can represent a large variety of alkyl groupings using as splitting agent one of the enantiomers R or S of N-tosyl-leucine.
Patent CA-2274805-A1 (CA)
Title: Pyk2 related products and methods
Inventor: LEV SIMA
IPC: C12N15/63
Filed: 1997-12-09
Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.
Patent CA-2277201-A1 (CA)
Title: Contour following tool and method
Inventor: JUSTIN LOUIS K
IPC: G01B5/207
Filed: 1998-01-08
Abstract: A contour following tool (14) for engaging the surface (46) of a workpiece (13) is disclosed. The tool has axially shiftable pins (32) that are biased toward a position in which they are fully extended from a housing. As the contoured surface (46) of the workpiece (13) is accommodated by allowing the pins (32) to shit back from their fully extended position against the biasing force. The pins may be biased by a fluid under pressure or by springs (62). The tool may be used with a wiping cloth (48) or end caps (70) that may apply a cleaning fluid that is applied either externally or internally through the tool through a bore (80) formed in one or more of the pins. An alternative embodiment is disclosed for gauging the contour of a surface. Another alternative embodiment is disclosed for an assembly tool (190). A clamping block (150) utilizing the invention is also disclosed. A method of cleaning a contoured workpiece is also disclosed.
Patent CA-2277348-A1 (CA)
Title: Curl-resistant, antislip abrasive backing and paper
Inventor: KRONZER FRANCIS JOSEPH
IPC: D21H27/14
Filed: 1999-07-14
Abstract: A curl-resistant, antislip abrasive backing which includes a polymer-reinforced paper having a first surface and a second surface; a synthetic polymeric layer bonded to the first surface; and an amorphous, rubbery polymer film layer bonded to the second surface. Also provided is a curl-resistant, antislip abrasive paper which includes a polymer-reinforced paper having a first surface and a second surface; a synthetic polymeric layer bonded to the first surface; a layer of abrasive particles bonded to the synthetic polymer layer; and an amorphous, rubbery polymer film layer bonded to the second surface. By way of examples, the amorphous, rubbery polymer may be a polyester elastomer or an amorphous, rubbery polypropylene.
Patent CA-2283790-A1 (CA)
Title: Improved multi-layer golf ball utilizing silicone materials
Inventor: KELLER VIKTOR
IPC: C08L23/08
Filed: 1998-03-27
Abstract: The present invention is directed to an improved multilayer golf ball (5) comprising a core (10), an inner cover layer (14) and an outer cover layer (16). The inner cover layer (14) is comprised of a high acid ionomer or ionomer blend. The outer cover layer (16) is comprised of a soft, very low modulus ionomer or ionomer blend, or a non-ionomeric thermoplastic elastomer such as polyurethane, polyester or polyesteramide. The golf ball further comprises at least one interior layer and/or a core comprising a silicone material.
Patent CA-2286064-A1 (CA)
Inventor: GRETHLEIN ECKHART
IPC: A61K47/20
Filed: 1998-04-07
Abstract: The invention relates to an improved extract of Hypericum perforatum (St.  John's-wort) containing approximately 0.1 % to 2 % hyperforine. The hyperforine contained in the inventive extract is stable for a longer period of time.
Patent CA-2286503-A1 (CA)
Inventor: BAMBARDEKAR SHAILESH SHASHIKAN
IPC: H02G3/18
Filed: 1999-10-07
Abstract: An in-floor, flush poke-through wiring fitting may be installed in the floor of a structure to enable the activation of power, communication, and/or data services at the fitting location. The poke-through fitting includes a height adjustable mounting bracket that provides for internal mounting of a variety of different low voltage data jacks (e.g. fiber optic, RJ-45 Category 5, coaxial, etc.). The mounting bracket includes a first portion that is mountable in the finish ring over an internal chamber of the poke-through fitting. The data jack is mounted in second portion of the mounting bracket that is mountable in the bracket first portion in a height adjustable manner, whereby the height of the bracket second portion may be adjusted relative to top assembly to accommodate service connectors of varying heights.
Patent CA-2287657-A1 (CA)
Title: Method for the management of an automatic branch exchange with the creation of a table of users, and corresponding automatic branch exchange
Inventor: LEBOULZEC DIDIER
IPC: H04M3/42
Filed: 1999-10-27
Abstract: The invention relates to a method for the management of an automatic branch exchange of the type interacting with a plurality of users by means of a plurality of user terminals. According to the invention, the method comprises the following steps: - the identification of each of said users by at least one user identifier; - the creation of a table of users, associating a user profile with said at least one user identifier of each user, each user profile comprising at least one attribute assigned to said user and especially a set of user terminals that is possibly vacant.  The interaction between said automatic branch exchange and each user takes place as a function of the user profile associated with said user.
Patent CA-2288537-A1 (CA)
Title: Grill with improved rotary heating elements
Inventor: DELPIERRE PHILLIP III
IPC: A47J37/04
Filed: 1999-11-03
Abstract: An improvement to a grill wherein the affective radius of a rotary heating element is locally varied to improve engagement and rotation of a food items, including next generation dough involved food items and the like, on the grill. Attachments for retrofitting of existing, commercially available grills, and methods of using the improved grills are disclosed.
Patent CA-2288968-A1 (CA)
Title: Permucous preparation
Inventor: YAZAKI TAKASHI
IPC: A61K38/08
Filed: 1998-04-13
Abstract: A permucous composition characterized by comprising Antago-3 or a physiologically acceptable salt thereof and a sucrose/fatty acid ester. The composition can serve as a pharmaceutical preparation which has the high permucous absorbability of physiologically active peptide Antago-3 and is unstimulative and stable for long.