baber/WOPTO huggingface dataset:
Patent CZ-302993-B6 (CZ)
Title: Process for preparing (2R,3R)-N,N-dimethyl-3-(hydroxyphenyl)-2-methylpentylamine (tapentadol)
Inventor: VLASAKOVA RUZENA
IPC: C07C209/70
Filed: 2010-12-30
Abstract: The present invention relates to a process for preparing optically pure or optically enriched tapentadol of the general formula I and pharmaceutically acceptable salts thereof, wherein O-protected (2R, 3R)-acids of the general formula II, in which R represents an alkyl group containing 1 to 4 carbon atoms, are reacted in the stage A in an inert organic solvent with an activating agent, optionally in the presence of a catalyst or base; in the stage B, the obtained compounds of the general formula III, in which R and Ri1 are as indicated above and X represents chlorine or an alkoxycarbonyloxy O-CO-ORe1 group or pivaloyloxy O-CO-t-Bu group, react with dimethylamine or salts thereof optionally in the presence of a base; in the stage C the obtained N,N-dimethylamides of the general formula IV, in which R is as defined above, are reduced by means of hydride agents in a suitable solvent; in the stage D the prepared alkenamines of the general formula V, in which R is as defined above, are hydrogenated on metal catalysts in a suitable solvent; and finally in the stage E the prepared alkanamines of the general formula VI, , in which R is as defined above are O-dealkylated by means of dealkylating agents, and in case of need the obtained tapentadol is converted by the action of pharmaceutically acceptable acids to corresponding salts such as hydrochloride.
Patent CZ-306803-B6 (CZ)
Title: Coated spherical pellets, their production and adjustment in detection tubes for the detection of cholinesterase inhibitors
Inventor: VETCHÝ DAVID
IPC: C12N11/084
Filed: 2016-05-26
Abstract: Spherical pellets comprising an immobilized enzyme based on cholinesterases having an activity of 1 to 100 nkat.g.sup..tvpom.1.n., while the enzyme is immobilized as a solid dispersion in a hydrophilic polymer which forms the primary pellet shell at a concentration of 5 to 15% by weight of the coated pellet which is subsequently coated with the secondary semipermeable coating of a water insoluble polymer at a concentration of 1 to 10% by weight of the coated pellet, while the average of the resulting size of the coated pellets is at least 75% in the range from 0.1 to 3.0 mm, preferably from 0.8 to 1.25 mm, as well as the method of production of pellet cores intended for application of the primary and, subsequently, the secondary coating which are produced by the method of extrusion-spheronization or rotogranulation, while these pellet cores are coated with both layers (the primary and secondary ones) in the fluidized layer and the resulting coated pellets are used to detect cholinesterase inhibitors in the form of a detection tube containing the aforementioned coated spherical pellets.
Patent CZ-308993-B6 (CZ)
Title: An energy source using low-enriched nuclear fuel to produce heat
Inventor: ČERMÁK FRANTIŠEK
IPC: G21D5/02
Filed: 2020-05-07
Abstract: The energy source using low-enriched nuclear fuel for producing heat comprises a compact transportable pressure vessel (3) containing a cylinder (2) in which the active zone (1) with a heating element (5) formed by nuclear fuel (4) and continuously stirred by a directed flow of heat exchange fluid . A second pressure vessel with a closed water bath circuit and a heat exchanger (7) for producing steam is connected to the pressure vessel (3), the compact transportable pressure vessel (3) is relocated in a space selected from the group of underground concrete space provided with a stainless steel cover, sea-river vessel and container treatment for road and / or rail transport.
Patent SK-284417-B6 (SK)
Title: Process for the conversion of threo-(2R,3R)-2-hydroxy-3-(2- aminophenylthio)-3-(4-methoxyphenyl)propionic acid derivatives
Inventor: ALLEGRINI PIETRO
IPC: C07B55/00
Filed: 1998-10-12
Abstract: A process for the conversion of threo-(2R,3R)-2-hydroxy-3- (2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid derivatives into threo-2-hydroxy-3-(2-aminophenylthio)-3-(4- methoxyphenyl)propionic acid esters, which are intermediates for the synthesis of diltiazem. The invention relates to a method for the recycle of a waste product of diltiazem synthesis.
Patent CZ-300969-B6 (CZ)
Title: Vacuum cleaner with technology combination
Inventor: MACHALA PETR
IPC: A47L9/16
Filed: 2004-12-06
Abstract: The present invention relates to a vacuum cleaner with technology combination of dust dry and wet separation consisting of a vacuum cleaner motor section (9) provided with a rotary separator (5) and a container (11) with water bath (4) in which a cyclone chamber (2) is disposed. In the vacuum cleaner motor section (9) being provided with an outlet (8) of purified air outlet (8) includes a high-speed electric motor (7) having mounted on its axis a suction turbine (6) and said rotary separator (5). Said cyclone chamber (2), being disposed in the middle of said container (11) is provided with a tangential inlet (1) of polluted air sucked in by the vacuum cleaner. The cyclone chamber (2) is further provided in its center with a socket (10) for discharge of a pre-purified air whereby said cyclone chamber (2) is encompassed by a shell creating a partition wall (3) between the cyclone chamber (2) and the container (11), wherein said partition wall (3) enables flow of the pre-purified air from the socket (10) down to the container (11) bottom and up to the water bath (4) via a sieve (12) with small openings arranged in skew direction along the tangent.
Patent SK-288367-B6 (SK)
Title: Infant formula
Inventor: BINDELS JACOB GEERT
IPC: A23L33/21
Filed: 2000-12-13
Abstract: The object of the invention is an infant formula comprising: a) a protein component, b) a lipid component, wherein the palmitic acid residues represent 10 % to 30 % by weight of all fatty acid residues, and which further comprises linoleic acid, alpha-linolenic acid, oleic acid, arachidonic acid and docosahexaenoic acid, wherein the palmitic acid residues make up 16 % to 24 % by weight of all fatty acid residues present in the triglycerides and of these palmitic residues at least 30 % is in the Sn2 position of the triglycerides, and which is characterized in that it further comprises c) a prebiotic component comprises a mixture of trans-galacto-oligosaccharides and fructo-oligosaccharides in the ratio from 5:1 to 15:1.
Patent BR-PI0107863-B8 (BR)
Title: método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
Inventor: JAMES ANDREW RAMSDEN
IPC: C07C229/08
Filed: 2001-01-11
Abstract: "síntese assimétrica da pregabalina". esta invenção proporciona um método de preparação do ácido (s)-(+)-3-(aminometil)-5-metilhexanôico (pregabalina) ou de um seu sal, através de uma síntese por hidrogenação assimétrica. a pregabalina é útil no tratamento e prevenção de distúrbios convulsivos, dores, e distúrbios psicóticos. a invenção também proporciona intermediários úteis na produção de pregabalina.
Patent BR-PI9506389-B8 (BR)
Title: composto de silício, e, composição dietética, cosmética e terapêutica.
Inventor: FRANCO ANDRÉ
IPC: A61P9/10
Filed: 1995-09-29
Abstract: patente de invenção: "composto à base de silício, aplicação da composição, 2-oxobenzil-oxi-dimetilsilano, composição terapêutica, composição dietética e composição cosmética resultantes da aplicação". composto à base de composto à base de silício de fórmula geral: na qual: - a, b, c e d são radicais diferentes de oh ligado ao si por ligações covalentes, - duas ou três destas ligações com o si são ligações do tipo si-o-c, si-s-c ou si-n-c, hidrolisáveis in vivo com formação de ligações si-oh biologicamente ativas, especialmente em contato com tecidos vivos, sendo as ligações a e d da fórmula b) sempre hidrolisáveis, - pelo menos uma das ligações hidrolisáveis corresponde a um radical acilóxi, ariloxi ou viniloxi, - pelo menos um dos compostos obtidos após hidrólise das ditas ligações hidrolisáveis é um estabilizante, e - as ligações não hidrolisáveis são do tipo si-c e correspondem a radicais hidrocabonetos ou fluorcarbonatos para os quais o si não está ligado a um só fenila.
Patent EP-1257766-B8 (EP)
Inventor: DEBECKER ANDY
IPC: B32B27/32
Filed: 2001-02-01
Granted: 2007-06-13
Abstract: The invention relates to a fibre-reinforced pressure vessel ( 1, 6 ) comprising a rigid gas- of fluid-tight body ( 2, 7, 13, 19 ) overwound with fibre filaments ( 3, 10,11, 18 ), whereby the fibre filaments are wound such that at least a number of fibre filaments can freely move with respect to one another and when the pressure vessel is under internal pressure the fibre filaments are loaded exactly in their longitudinal direction. The invention also relates to a method of manufacturing a fibre-reinforced pressure vessel whereby no matrix material (for example, resin) is used so that at least a number of fibre filaments would be incorporated in a matrix for that section of the pressure vessel in which the fibre filaments can freely move with respect to one another.
Patent EP-2081722-B8 (EP)
Inventor: CARL MARTIN
IPC: B23K1/00
Filed: 2007-06-26
Granted: 2011-03-02
Abstract: Verfahren zur Herstellung eines Wärmetauschers mit folgenden Schritten: a) Schmelztauchveredeln eines Stahlblechs zur Ausbildung einer Korrosionsschutzschicht (3), wobei die Korrosionsschutzschicht (3) Zink und zwischen 0,5 % und 60 % Aluminium enthält; b) Entfernung der Korrosionsschutzschicht (3) von einer Seite des Stahlblechs; c) Herstellung eines Wärmetauscherrohrs (2) aus diesem Stahlblech, wobei die Korrosionsschutzschicht (3) außenseitig angeordnet ist; d) Bereitstellen von Rippen (6) aus Aluminium oder einer Aluminiumlegierung; e) Bereitstellen eines Flussmittels; f) Bereitstellen eines Aluminium und Silizium enthaltenden Lötmaterials (8) im Verbindungsbereich zwischen den Rippen (6) und der Außenseite des Wärmetauscherrohrs (2); g) Verbindung des Wärmetauscherrohrs (2) mit den Rippen (6) in einem Hartlötvorgang.
Patent BR-PI0208021-B8 (BR)
Inventor: RÖJER EVA
IPC: C07K14/47
Filed: 2002-03-15
Abstract: The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.
Patent BR-PI0304186-B8 (BR)
Inventor: XIUGUO CUI
IPC: H04J14/02
Filed: 2003-09-22
Abstract: The invention discloses a transparent transmission method for administrative information of SDH devices manufactured by multi-vendors. First, idle overhead bytes of a frame structure of synchronous transfer mode are defined to transfer administrative information of other vendors. At each node of a transmission network, the administrative information is extracted and transformed to a uniform format. After time slot cross, transmission direction of each vendor's administrative information is defined. After format transformation has been implemented again, the administrative information of each vendor is inserted in a frame structure of a designated line. After that, the frame transfers each vendor's administrative information to other nodes, the rest can be deduced by analog, until administrative information of other vendors is transferred to a designated position. With this method, administrative information of SDH devices of multi-vendors can be transparently transmitted over SDH devices of a certain vendor. Moreover, this method is simple and reliable. <IMAGE>
Patent BR-PI0514263-B8 (BR)
Inventor: DESTARDI MOYE-SHERMAN
IPC: C07D241/08
Filed: 2005-08-19
Abstract: Provided is a method for the synthesis of N-protected 3,6-bis-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
Patent BR-PI0607817-B8 (BR)
Title: compostos macrocíclicos e seu processo de preparação
Inventor: AZAD HOSSAIN
IPC: C07K5/08
Filed: 2006-03-06
Abstract: processo para a preparação de compostos macrocíclicos. a presente invenção refere-se a um processo para preparar um composto macrocíclico de fórmula (i) onde um composto macrocíclico hidroxil-substituído de fórmula (3) é reagido com um composto sulfonil-substituído de fórmula quin: os compostos de fórmula (i) são agentes ativos potentes para o tratamento de infecção pelo vírus da hepatite o (hcv).
Patent BR-PI0819319-B8 (BR)
Title: análogos de aminoglicosídeo antibacteriano
Inventor: ADAM AARON GOLDBLUM
IPC: A61P31/04
Filed: 2008-11-21
Abstract: análogos de aminoglicosídeo antibacteriano compostos de estrutura (1): tendo atividade antibacteriana são divulgados, incluindo estereoisômeros, sais e pró-fármacos farmaceuticamente aceitáveis dos mesmos, em que q1, q2, q3, r8 e r9 são como aqui definidos. métodos associados à preparação e uso de tais compostos, bem como composições farmacêuticas compreendendo tais compostos, são também descritos.
Patent BR-PI0820129-B8 (BR)
Title: processo de formação de uma sutura autorretentora e sutura autorretentora
Inventor: ALEXANDER NAIMAGON
IPC: A61B17/068
Filed: 2008-12-19
Abstract: suturas autorretentoras com retentores mediados por contato térmico. são proporcionadas na presente invenção suturas que vão ser usadas em um procedimento aplicado em tecido e processo para a formação dessas suturas. uma sutura pode incluir um corpo de sutura alongado e uma pluralidade de retentores mediados por contato térmico estendendo-se de e ao longo do corpo de sutura alongado. os retentores mediados por contato elétrico podem ser formados por contato temporário do corpo de sutura alongado com um ou mais elementos aquecidos.
Patent BR-PI0920280-B8 (BR)
Title: Composição alimentícia, e, método para fabricar uma composição alimentícia
Inventor: GEOFFREY BROOKS
IPC: A23D7/005
Filed: 2009-10-14
Abstract: COMPOSIÇÃO, MÉTODOS PARA FABRICAR UMA COMPOSIÇÃO ALIMENTÍCIA, PARA PREPARAR BIOMASSA DE ALGA, E ÓLEO DE ALGA, PARA PRODUZIR UM ÓLEO OU BIOMASSA MICROBIANA, E PARA INDUZIR SACIEDADE, BIOMASSA DE ALGA, PRODUTO DE RAÇÃO ANIMAL, E, HOMOGENEIZADO DE BIOMASSA DE ALGA A invenção fornece biomasa algal, óleo algal, composições alimentares compreendendo biomassa microalgal, células microalgais inteiras, e/ou óleo microalgal em combinação com um ou mais outros ingredientes comestíveis, e métodos para fabricar tais composições combinando biomassa algal ou óleo algal com outros ingredientes comestíveis. Em modalidades preferenciais, os componentes microalgais são derivados de culturas microalgais cultivadas de forma heterotróficas, nas quais as células algais compreendem pelo menos 10% de óleo algal em peso seco.
Patent AU-2002303551-B8 (AU)
Title: DELTA4-desaturase genes and uses thereof
Inventor: MUKERJI PRADIP
IPC: A23L9/10
Filed: 2002-05-02
Granted: 2002-11-18
Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., "Delta4-desaturase"). In particular, Delta4-desaturase may be utilized, for example, in the conversion of adrenic acid to omega6-docosapentaenoic acid and in the conversion of omega3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
Patent AU-2006297779-B8 (AU)
Title: Axial flow pump with multi-grooved rotor
Inventor: LAROSE JEFFREY A
IPC: A61M60/824
Filed: 2006-06-02
Granted: 2013-03-21
Abstract: An axial-flow blood pump for pumping blood includes a substantially cylindrical outer enclosure. A tubular housing concentric with and located within the outer enclosure has at one end an inlet and at an opposite end an outlet. A motor stator is concentric with and located between the outer enclosure and the tubular housing. An impeller is concentric with and located within the tubular housing. The impeller is suspended in operation by a combination of passive magnetic forces between magnets within the impeller or magnetized regions of the impeller and the motor stator and hydrodynamic thrust forces generated as blood flows between the tubular housing and a plurality of hydrodynamic thrust bearing surfaces located on the impeller. A volute may be in fluid-tight connection with the outlet of the tubular housing for receiving blood in the axial direction and directing blood in a direction normal to the axial direction. The volute has a flow-improving member extending axially from the volute and into and coaxially with the tubular housing.
Patent AU-2007240240-B8 (AU)
Title: Series arc fault current interrupters and methods
Inventor: RIVERS CECIL
IPC: H02H7/26
Filed: 2007-12-11
Granted: 2011-08-04
Abstract: 379.8489USU1 SERIES ARC FAULT CURRENT INTERRUPTERS AND METHODS A circuit interrupter (10) for interrupting current on a line conductor (20) is provided. The circuit interrupter includes separable contacts (24), a trip mechanism (26), a bimetal (30), a microprocessor (12), a series arc detection sequence (14), a low-pass filter circuit (38), and a high-pass filter circuit (36). The trip mechanism selectively opens the separable contacts when activated. The series arc detection sequence is resident on the microprocessor and includes a plurality of series fault detection algorithms (72, 76, 80, 84). The low pass filter circuit provides a low-pass signal (48) to the series arc detection sequence. The high-pass filter circuit provides a high-pass signal (46) to the series arc detection sequence. The sequence selects a particular algorithm from the plurality of algorithms based on the low-pass signal. The sequence calculates a plurality of statistical features from the high-pass signal and sends an output signal (54) to activate the trip mechanism based on a comparison of the plurality of statistical features to the particular algorithm. At -Jd!C5
Patent AU-2011345318-B8 (AU)
Title: Methods and systems for performing cross store joins in a multi-tenant store
Inventor: EIDSON BILL C
IPC: G06F17/00
Filed: 2011-04-15
Granted: 2017-10-05
Abstract: Methods and systems for performing cross store joins in a multi-tenant store are described. In one embodiment, such a method includes retrieving data from a multi-tenant database system having a relational data store and a non-relational data store, receiving a request specifying data to be retrieved from the multi-tenant database system, retrieving, based on the request, one or more locations of the data to be retrieved, generating a database query based on the request, in which the database query specifies a plurality of data elements to be retrieved, the plurality of data elements including one or more data elements residing within the non-relational data store and one or more other data elements residing within the relational data store, and executing the database query against the multi-tenant database system to retrieve the data.
Patent BR-112015004848-B8 (BR)
Title: Método para produção de uma célula de planta transgênica
Inventor: NOEL COGAN
IPC: C12N15/82
Filed: 2013-09-06
Abstract: MÉTODO PARA PRODUÇÃO DE UMA CÉLULA DE PLANTA TRANSGÊNICA. A presente invenção refere-se a uma Plataforma de Integração de Transgene Engenheirada (ETIP), a qual pode ser inserida aleatoriamente ou em locais direcionados em genomas de planta para facilitar seleção e detecção rápidas de um GOI que é perfeitamente direcionável (ambas as extremidades 5' e 3') na localização genômica de ETIP. Um elemento na presente descrição é a introdução de quebras de filamento duplo específicas dentro da ETIP. Em algumas modalidades, a ETIP é descrita usando sítios de ligação de nuclease dedo de zinco, mas podem ser utilizadas outras tecnologias de direcionamento tais como meganucleases, CRISPRs, TALs ou zíperes de leucina. São também descritas composições de, e métodos para produção de, plantas transgênicas onde o DNA de doador ou payload expressa um ou mais produtos de uma sequência de ácido nucleico exógena (por exemplo, proteína ou RNA) que foi estavelmente integrada a uma ETIP em uma célula de planta. Em modalidades, a ETIP facilita teste de genes candidatos e vetores de expressão de planta de ideação através de Fases de desenvolvimento.
Patent NL-2028595-B9 (NL)
Title: Device and method for indicating a concentration of a beverage
Inventor: ADRIANUS JOHANNES MARIA TILBURG
IPC: G01N33/14
Filed: 2021-06-30
Granted: 2023-01-19
Abstract: Indicator device for indicating a concentration of a beverage prepared by extracting at least one compound from a beverage preparation material, such as an infusion or steeping process for the preparation of tea or the like, wherein the indicator device comprises a carrier provided with an optical indicator, wherein the carrier is arranged to be inserted into the beverage for exposing the optical indicator to the beverage, wherein the optical indicator is arranged to indicate whether a concentration of the compound in the beverage corresponds to a predetermined reference concentration of the compound, wherein the compound is a cannabinoid.
Patent EA-023877-B9 (EA)
Title: Skull imitatin device for medical training surgeons and method
Inventor: TVERMOES CHRISTINA VIRKELYST
IPC: G09B23/34
Filed: 2012-04-03
Abstract: The present invention relates to a medical training device, preferably being shaped as at least a part of a human or animal skull. The training device comprises at least three elements: an element imitating the skull, an element imitating soft tissue, typically being a brain or a part thereof, and an element imitating a meninge or part thereof, preferably being the dura mater. The invention also relates to a method of training surgeons.
Patent AU-2002334484-B9 (AU)
Title: Method and apparatus for weed control with hot foam
Inventor: REID DAVID GARTH
IPC: E01H11/00
Filed: 2002-09-27
Granted: 2009-05-21
Abstract: A method of controlling vegetation including the steps of: (a) preparing a relatively 'wet' foam having a temperature between 75° C. and 100° C. and consisting volumetrically of 60% to 75% aqueous solution of biodegradable foaming agent and 40% to 25% air, and (b) directing a stream of the foam against the surface to be treated. An apparatus for applying the foam to vegetation including a supply tank for holding an acqueous foamable solution, a pump for supplying the solution to a boiler for heating, a blower for supplying air, hoses for carrying air and hot solution respectively to a lance incorporating a mixing and expansion chamber.
Patent AU-2014336929-B9 (AU)
Title: Salt and crystal forms of PLK-4 inhibitor
Inventor: SAMPSON PETER BRENT
IPC: A61P35/00
Filed: 2014-10-17
Granted: 2019-03-21
Abstract: A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer. Compound (I)