baber/WOPTO huggingface dataset:
Patent AU-2019253212-A1 (AU)
Title: De-immunized Factor VIII molecule and pharmaceutical compositions comprising the same
Inventor: WINTERLING KARINA
IPC: C12N9/64
Filed: 2019-04-11
Abstract: The present invention relates to the field of therapeutic proteins, in particular, to recombinant coagulation factors. It provides a recombinant Factor VIII (FVIII) protein comprising specific point mutations at defined positions, which serve to reduce the immunogenicity of said FVIII protein, wherein the Factor VIII protein substantially retains its coagulant activity. It further provides nucleic acids encoding said de-immunized protein, cell lines and methods of recombinant preparation as well as pharmaceutical compositions comprising the recombinant FVIII of the invention, which are advantageous for use in treatment of patients with Hemophilia A, particularly those who have not yet been treated with a FVIII product. Additionally, it can be a safe alternative for previously treated patients and even for patients who have developed an immune-response to FVIII, e.g., for immune-tolerance-induction therapy (ITI/ITT) or rescue ITI. The invention also provides an assay for determining immunogenicity of a protein.
Patent AU-2019256717-A1 (AU)
Title: Methods and kits for optimization of neurosurgical intervention site
Inventor: ZAHID ABDULLAH BIN
IPC: A61B34/10
Filed: 2019-04-19
Abstract: Methods and systems for aiding in placement of surgical intervention sites for treating lesions for optimization of surgical outcomes are provided. Also disclosed are computer- aided software packages for identifying the optimal placement of a surgical intervention on a patient in need thereof. The packages, systems, and methods for optimizing placement provided herein help to achieve superior results (e.g. increased drainage), decrease hospitalization time, reduce recurrence of lesions and need for drainage, and improve cognitive outcomes for patients.
Patent AU-2019261395-A1 (AU)
Title: Rechargeable robotic pool cleaning apparatus
Inventor: ERLICH GUY
IPC: B63H11/04
Filed: 2019-04-24
Abstract: A rechargeable robotic pool cleaning apparatus having a first water pump for providing a downward thrust force, a second water pump for providing at least a rearward thrust component, and a third water pump for providing at least a forward thrust component, the apparatus being buoyant when the pumps are not activated and including adjustable flap valves, baffles and nozzles to alter the outflow direction of at least some of the jet streams of water produced by the pumps so as to produce any one or more of a vertical, forward, rearward, and sideward thrust component depending upon the positioning of the baffles and/or nozzle members. At least one main controller is electronically coupled to a rechargeable power source for controlling the operation of the pumps in various combinations for moving the apparatus both vertically and horizontally in the body of water.
Patent AU-2019276000-A1 (AU)
Title: Safinamide for treating myotonia
Inventor: DESAPHY JEAN-FRANÇOIS
IPC: A61K31/165
Filed: 2019-05-28
Abstract: The present invention relates to safmamide or a pharmaceutically acceptable salt thereof for use in the treatment of a condition caused by pathological sarcolemma hyperexcitability, and/or of any other condition in which the restoration of normal sarcolemma excitability may produce a therapeutic benefit or improvement, wherein said condition is preferably a myotonic disorder.
Patent AU-2019328513-A1 (AU)
Title: A crusher mantle lifting device, an arrangement and a method
Inventor: MALKAMÄKI Mikko
IPC: B02C23/00
Filed: 2019-08-30
Abstract: The present invention relates to a crusher mantle lifting device. Attachment elements are configured to be attachable to a crusher mantle. Each attachment element comprises a main portion having an inner surface facing the mantle and an outer surface. A locking portion projects from the inner surface and is configured to protrude into a corresponding opening in the mantle. One or more lifting portions project from the outer surface. A tightening means is configured to press the attachment elements towards the crusher mantle. The invention also relates to an arrangement and a method.
Patent AU-2019336221-A1 (AU)
Title: Generation of hematopoietic progenitor cells from human pluripotent stem cells
Inventor: THOMSON JAMES A
IPC: C12N5/0783
Filed: 2019-09-06
Abstract: Methods for generating and using hematopoietic progenitor cells are described.
Patent AU-2019361942-A1 (AU)
Title: Nicotinic acetylcholine receptor peptide antagonist conotoxin compositions and related methods
Inventor: LOVE ROBERT A
IPC: A61P43/00
Filed: 2019-10-15
Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.
Patent AU-2019362059-A1 (AU)
Title: Arginine depletion therapy for treatment of GAMT deficiency
Inventor: QUINN ANTHONY
IPC: A61K38/50
Filed: 2019-10-18
Abstract: Methods and compositions therefor of treating GAMT deficiency or guanidino acetate (GAA) toxicity in a subject comprising administration of an arginine depleting enzyme. An therapeutic formulation can include an arginase, an arginine deiminase or a combination thereof and optionally other compounds, and can be adapted for intravenous or subcutaneous administration to a subject.
Patent AU-2019364756-A1 (AU)
Title: Dual-route administration of composition for improved protection of plants against pathogens
Inventor: BARAZANI AVNER
IPC: A01N43/12
Filed: 2019-10-20
Abstract: The present invention provides a method for preventing and/or treating infection of plant species by fungal, mildew-causing, bacterial and/or viral pathogens, wherein said method comprises the steps of a) providing a mixture of one or more non-pathogenic bacteria and one or more activating agents, and b) administering the mixture of step (a) to said plant species, by means of both (i) adding a plurality of granules coated with said mixture to the medium in which said plant is growing, and (ii) applying a foliar spray comprising said mixture to the aerial parts of said plant species.
Patent AU-2019369913-A1 (AU)
Title: Pharmaceutical composition containing alkyl carbamoyl naphthalenyloxy octenoyl hydroxyamide phosphate, tartrate or combination thereof, and preparation method therefor
Inventor: CHO JAE PYOUNG
IPC: A61K9/00
Filed: 2019-10-28
Abstract: The present invention relates to a pharmaceutical composition containing an alkyl carbamoyl naphthalenyloxy octenoyl hydroxyamide phosphate compound (hereinafter referred to as CG200745PPA) or a derivative thereof, and can provide a pharmaceutical composition in a tablet, granule, powder, capsule, dry syrup or injection form. By providing the composition in various forms, a suitable form can be selected and easily applied when oral administration is difficult.
Patent AU-2019374654-A1 (AU)
Title: Gene therapy employing genome editing with single AAV vector
Inventor: NISHIGUCHI KOJI
IPC: C12N15/864
Filed: 2019-11-08
Abstract: An adeno-associated virus (AAV) vector which can be used for the insertion of a desired nucleic acid into a nucleic acid in a cell, wherein, when as observed in the direction from the 5'-terminal toward the 3'-terminal, the nucleic acid in the cell contains a region comprising a first nucleotide sequence and a region comprising a second nucleotide sequence, the vector contains a first gRNA target sequence, a region comprising a first nucleotide sequence, the desired nucleic acid, a region comprising a second nucleotide sequence, a second gRNA target sequence, a cell-specific promoter, a sequence encoding Cas9 nuclease, an RNA polymerase III promoter, a sequence encoding first gRNA capable of recognizing the first gRNA target sequence, and a sequence encoding second gRNA capable of recognizing the second gRNA target sequence, the vector can generate a nucleic acid fragment which contains a region comprising a first nucleotide sequence, the desired nucleic acid, and a region comprising the second nucleotide sequence by the action of the Cas9 nuclease, and the first nucleotide sequence in the nucleic acid in the cell and the first nucleotide sequence in the vector are linked to each other through microhomology-mediated end joining and the second nucleotide sequence in the nucleic acid in the cell and the second nucleotide sequence in the vector are linked to each other through microhomology-mediated end joining so that the desired nucleic acid is inserted in a region between the region comprising the first nucleotide sequence and the region comprising the second nucleotide sequence in the nucleic acid in the cell.
Patent AU-2019379744-A1 (AU)
Title: Method for producing aerogels and aerogels obtained using said method
Inventor: HINTEMANN DAMIAN
IPC: C01B33/158
Filed: 2019-11-06
Abstract: The invention relates to a method for producing an aerogel under increased pressure, to the aerogels obtained using said method and to their use.
Patent AU-2019412799-A1 (AU)
Title: Article, system, and method for indication of treatment
Inventor: OMIDBAKHSH NAVID
IPC: A61L2/28
Filed: 2019-11-04
Abstract: An article, a system, and a method for indication of treatment are provided. The article comprises a first body, a second body, and a treatment indicator. The first body comprises a first axis, a cavity, a first port, and a second port. The cavity is positioned within the first body and configured to receive the second body. The second body comprises a second axis, a chamber, a third port, and a fourth port. The article is configured to move between a first configuration and a second configuration. In the first configuration, the first port is aligned with the third port to form a fluid pathway to the chamber, and the second port is aligned with the fourth port to form a fluid pathway to the chamber. In the second configuration, the first port is misaligned with the third port, and the second port is misaligned with the fourth port.
Patent AU-2019421376-A1 (AU)
Title: Semiconductor fabrication
Inventor: KALLAHER RAYMOND LEONARD
IPC: H01L27/18
Filed: 2019-12-31
Abstract: In-situ patterning of semiconductor structures is performed using one or more "shadow walls" (408) in conjunction with an angled deposition beam (110). A shadow wall protrudes outwardly from the surface of a substrate to define an adjacent shadow region in which deposition is prevented due to the shadow wall inhibiting the passage of the angled deposition beam. Hence, deposition will not occur on a surface portion of a semiconductor structure (108) within the shadow region. Shadow walls can thus be used to achieve selective patterning of semiconductor structures. The shadow walls themselves are formed of semiconductor. In one implementation, the semiconductor structure and the one or more shadow walls used to selectively pattern it is formed using selective area growth (SAG).
Patent AU-2019444631-A1 (AU)
Title: Reaction mixer
Inventor: HUTCHINSON TODD MICHAEL
IPC: B01J19/18
Filed: 2019-06-05
Abstract: An agitator or mixer installed in a solid-liquid-gas/slurry reactor in which gas removal from the slurry and foam destruction is promoted. The reaction mixer includes a vessel and an agitator assembly. The vessel is for containing the solid-liquid-gas mixture and defines two mixing zones within a given volume; a first mixing zone and a second mixing zone located above the first mixing zone. The agitator assembly is positionable within the vessel and comprises a rotatable shaft and a first and second impeller coupled to the shaft. The first axial impeller is locatable within the first mixing zone and is configured to pump the liquid in a downward direction along a vertical axis of rotation. The second impeller is locatable within the second mixing zone and is configured to pump the liquid in an upward direction along the vertical axis of rotation.
Patent AU-2019459233-A1 (AU)
Title: Different forms of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide
Inventor: NAM KIYEAN
IPC: C07D471/04
Filed: 2019-07-30
Abstract: The present invention relates to different forms of the compound 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide and to methods of making such forms/compounds. The present invention furthermore relates to mono-acid addition salts thereof, to methods of making such mono-acid addition salts and to pharmaceutical compositions comprising any of the aforementioned compounds. Furthermore, the present invention relates to uses of any of these compounds.
Patent WO-2020191450-A1 (WO)
Title: A dispenser
Inventor: CROSER ANGUS
IPC: A01M25/00
Filed: 2020-03-27
Abstract: A bait dispensing station including a cavity for holding a pellet of bait. The cavity can be enclosed preventing external access to the pellet. The statin also includes a compartment for holding a plurality of pellets and a means of dispensing a pellet into the cavity. A new pellet can only be dispensed into the cavity when no pellets are in the cavity. The cavity incudes a sensor to determine if there is a pallet in the cavity. The dispensing station includes a light sensor that controls access to the cavity and wherein access to the cavity is enabled essentially at night.
Patent WO-2021035306-A1 (WO)
Inventor: DANTANARAYANA MUDITHA PRADEEP
IPC: A61M16/06
Filed: 2020-08-28
Abstract: A patient interface may include a dual chamber cushion assembly having a nasal chamber and an oral chamber. The nasal chamber may be arranged to deliver pressurized breathable gas to a patient's nasal passages, and the oral chamber may be arranged to deliver pressurized breathable gas to the patient's oral passages. The nasal chamber may be pressurized to a different level than an oral chamber to promote nasal breathing. An air passage may fluidly connect the nasal chamber and the oral chamber so that pressurized breathable gas may flow from the nasal chamber to the oral chamber.
Patent AU-2020200941-A1 (AU)
Title: Octocrylene-free sunscreen composition with low stickiness
Inventor: SCHADE TATJANA
IPC: A61K8/35
Filed: 2020-02-10
Abstract: Abstract A cosmetic sunscreen composition comprising a UV filter combination of a) 4-(tert-butyl)-4'-methoxydibenzoylmethane, b) 2,4,6-tris[anilino(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazine (INCI: Ethylhexyl Triazone), 5 c) 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI: Bis-Ethylhexyloxyphenol methoxyphenyl Triazine), d) 2-phenylbenzimidazole-5-sulfonic acid salts.
Patent AU-2020203374-A1 (AU)
Title: Pipe trailer
Inventor: BELETICH MARK JOSEPH
IPC: B60P1/48
Filed: 2020-05-22
Abstract: PIPE TRAILER 
ABSTRACT 
A movable pipe trailer for presenting pipes for installation including a loading cradle for 
receiving and storing a plurality of pipes, at least one lifting arm for receiving a pipe from the 
loading cradle and raising the pipe into a raised presentation position and a loading cam for 
moving the pipe from the loading cradle onto the lifting arms.
Patent AU-2020209432-A1 (AU)
Title: Direct carbon dioxide capture from air
Inventor: DE NEVE HANS
IPC: B01D53/06
Filed: 2020-01-20
Abstract: The present invention concerns a device and process for capturing CO
Patent AU-2020213695-A1 (AU)
Title: A microfluidic device and a method for provision of double emulsion droplets
Inventor: KVIST THOMAS
IPC: B01F13/10
Filed: 2020-01-31
Abstract: A microfluidic device, a method for manufacturing a microfluidic device, and a method for provision of double emulsion droplets using a microfluidic device. Furthermore, an assembly configured to supply pressure to the microfluidic device for provision of double emulsion droplets. Furthermore, a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the microfluidic device for provision of double emulsion droplets.
Patent AU-2020228058-A1 (AU)
Title: Computational modeling of loss of function based on allelic frequency
Inventor: BARBACIORU CATALIN
IPC: G16B20/20
Filed: 2020-02-27
Abstract: The disclosure relates to computer technology for precision diagnosis of various states of genetic material such as a gene sequenced from cell-free DNA in a sample. The state may include a somatic homozygous deletion, a somatic heterozygous deletion, a copy number variation, or other states. A computer system may generate competing probabilistic models that each output a probability that the genetic material is in a certain state. Each model may be trained on a training sample set to output a probability that the genetic material is in a respective state. In some embodiments, the computer system may use various probabilistic distributions to generate the models. For example, the computer system may use a beta-binomial distribution, a binomial distribution, a normal (also referred to as "Gaussian") distribution, or other type of probabilistic modeling techniques.
Patent AU-2020228579-A1 (AU)
Title: Medication delivery device with sensing system
Inventor: CONNAUGHTON EOIN PATRICK
IPC: A61M5/315
Filed: 2020-02-20
Abstract: Medication delivery devices are provided having a dose delivery sensing capability. A dose button includes a support and a cover that at least partially encloses an electronics assembly including a sensor for detecting rotation of a component during dose delivery to determine a dosage of delivered medication. The electronics assembly includes a controller for receiving a signal from the sensor. The medication delivery device may be configured to communicate dosage delivery information to an external device.
Patent AU-2020232494-A1 (AU)
Title: Surface-modified nanodiamond, nanodiamond dispersion composition, and surface-modified nanodiamond production method
Inventor: SHIRO DAISUKE
IPC: B82Y40/00
Filed: 2020-02-10
Abstract: Provided is a polyoxyalkylene chain surface-modified nanodiamond demonstrating excellent productivity and excellent safety during production.　This surface-modified nanodiamond contains a nanodiamond particle and a surface-modification group having a polyoxyalkylene chain and a silicon atom for modifying the surface of the nanodiamond particle. This nanodiamond dispersion composition contains a dispersion medium and the surface-modified nanodiamond dispersed in the dispersion medium.
Patent AU-2020233650-A1 (AU)
Title: Riluzole prodrugs and their use
Inventor: WROBEL JAY EDWARD
IPC: C07D277/82
Filed: 2020-09-15
Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful 
for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer 
through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism 
5 and are delivered into systemic circulation by oral administration, and then cleaved to release 
riluzole in the plasma via either an enzymatic or general biophysical release process.  
233
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Figure 1: Time concentration curve for example 125 and released riluzole via both intravenous and 
oral administration.  
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Patent AU-2020233786-A1 (AU)
Title: Electronic gaming machine and method for providing a plurality of game outcomes and evaluating patterns of game outcomes to provide additional awards
Inventor: SCHREIBER MICHAEL
IPC: G07F17/32
Filed: 2020-09-20
Abstract: P05398USU1 (33050-2865) 
ABSTRACT 
An electronic gaming machine includes a processor configured to control a display device 
to display a matrix of game positions, initiate a plurality of games, and control the display device 
to display each game of the plurality of games in an associated game position of the matrix of 
game positions. The processor is also configured to determine an outcome of each game, where 
each outcome is a qualifying outcome or a non-qualifying outcome, as well as to evaluate the 
matrix of game positions to determine whether a qualifying pattern is formed in the matrix by at 
least two qualifying outcomes. In response to the qualifying pattern being formed, the processor 
is also configured to provide an award to a player of the electronic gaming machine. Each outcome 
may be individually evaluated to provide one or more additional awards to the player as well.  
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Patent AU-2020240109-A1 (AU)
Title: Methods and compositions for editing nucleotide sequences
Inventor: LIU DAVID R
IPC: C12N15/11
Filed: 2020-03-19
Abstract: The present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The nucleotide change can include a single- nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to a strand of the targeted endogenous DNA sequence to be edited, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incoporated into the target DNA molecule. Also disclosed herein are various methods that leverage prime editing, including treating trinucleotide repeat contraction diseases, installing targeted peptide tags, treating prion disease through the intallation of protection mutations, manipulating RNA-encoding genes for the installation of RNA tags for controlling the function and expression of RNA, using prime editing to construct sophisticated gene libraries, using prime editing to insert immunoepitopes into proteins, use of prime editing to insert inducible dimerization domains into protein targets, and delivery methods, among others.
Patent AU-2020263112-A1 (AU)
Title: Compounds comprising N-methyl-2-pyridone, and pharmaceutically acceptable salts
Inventor: WOODLAND ANDREW
IPC: C07D471/04
Filed: 2020-04-22
Abstract: The present invention concerns compounds comprising N-methyl-2-pyridone, and pharmaceutically-acceptable salts and compositions of such compounds. Such compounds are useful in anti-inflammatory and anti-cancer therapies. Therefore, the present invention also concerns such compounds for use as medicaments, particularly for the treatment of inflammatory diseases and oncology.