baber/WOPTO huggingface dataset:
Patent CR-20220149-A (CR)
Title: Dosing for anti-tryptase antibodies
Inventor: RYMUT SHARON MARIE
IPC: C07K16/40
Filed: 2020-09-18
Abstract: , methods of treating a patient having asthma by administering an anti-tryptase antibody (e.g., anti-tryptase beta antibody) to the patient, anti-tryptase antibodies (e.g., anti-tryptase beta antibodies) for use in treating asthma, and uses of anti-tryptase antibodies (e.g., anti-tryptase beta antibodies), e.g., in the manufacture of medicaments for treating asthma.
Patent EC-SP034867-A (EC)
Title: MÉTODOS PARA ADMINISTRAR ANTICUERPOS ANTI-TNFa
Inventor: KEMPENI JOACHIM
IPC: A61P35/00
Filed: 2003-11-27
Abstract: Métodos para tratar trastornos en los cuales tiene injerencia el TNFa, que comprenden la administración subcutánea, cada dos semanas, de anticuerpos humanos, preferiblemente anticuerpos recombinantes humanos, que se unen al factor de necrosis tumoral humano a (hTNFa). El anticuerpo puede administrarse con o sin metotrexato. Estos anticuerpos tienen una alta afinidad por hTNFa (por ejemplo, Kd = 10-8 M o menos), una baja velocidad de salida para la disociación con hTNFa (por ejemplo, Koff = 10-3 sec-1 o menos) y neutralizan la actividad de hTNFa in vitro e in vivo. Un anticuerpo de la invención puede ser un anticuerpo completo o una porción de unión a antígeno del mismo. También se incluyen conjuntos de elementos (kits) que contienen una composición farmacéutica e instrucciones para su dosificación, y jeringas cargadas que contienen composiciones farmacéuticas
Patent EC-SP045322-A (EC)
Title: Formulaciones de un anhidrato en suspensión con hfa
IPC: A61K47/20
Filed: 2004-09-28
Abstract: La invención se refiere a formulaciones con gas portador que contienen suspensiones del anhidrato cristalino de bromuro de (1a,2b,4b,5a,7b)-7-[(hidroxidi-2- -tienilacetil)oxi]-9,9-dimetil-3-oxa-9-azonia-triciclo[3.3.1.02,4]nonano.
Patent EC-SP055962-A (EC)
Title: Dispositivo de advertencia de seguridad ergonomica y metodo para prevenir el incendio del embrague en una torre de servicio de pozo
Inventor: NEWMAN FREDERIC M
IPC: B66D1/54
Filed: 2005-08-11
Abstract: Por lo tanto, esta invención proveerá una herramienta par asistir al operador del equipo para perfeccionar sus habilidades del operador del equipo. Expuesto en la presente está un aparato y un método para minimizar la pérdida de la velocidad en el pedal del tambor de una torre de servicio de pozo. Un sensor detecta la moción del compuesto cuando el pedal inicialmente es engranado. Si el momento está en un nivel aceptable, una alarma suena, notificando al operador de presionar más suavemente el pedal. Un mecanismo de rastreo se divulga para que el supervisor del equipo o la persona de seguridad pueda criticar al operador en la suavidad de la operación del equipo.
Patent EC-SP067099-A (EC)
Inventor: CASTRO ALFREDO
IPC: C07D261/02
Filed: 2006-12-20
Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
Patent EC-SP941102-A (EC)
Inventor: ELLIS PETER
IPC: A61K31/535
Filed: 1994-06-09
Abstract: The use of a compound of formula (I) wherein R1 is H; C1-C3 alkyl; C1-C3 perfluomalkyl; or C3-C5 cycloalkyl; R2 is H; optionally substituted C1-C6 alkyl; C1-C3 pefluoroalkyl; or C3-C6 cycloalkyl; R3 is optionally substituted C1-C6 alkyl; C1-C6 perfluoroalkyl; C3-C5 cycloalkyl; C3-C6 alkenyl; or C3-C6 alkynyl; R4 is optionally substituted C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkanoyl, (hydroxy)C2-C4 alkyl or (C2-C3 alkoxy)C1-C2 alkyl; CONR5R6; CO2R7; halo; NR5R6; NHSO2NR5R6; NHSO2R8; SO2NR9R10; or phenyl, pyridyl, pyrimidinyl, imidazolyl, oxazolyl, thiazolyl, thienyl or triazolyl any of which is optionally substituted with methyl; R5 and R6 are each independently H or C1-C4 alkyl, or together with the nitrogen atom to which they are attached form an optionally substituted pyrrolidinyl, piperidino, morpholino, 4-N(R11)-piperazinyl or imidazolyl group; R7 is H or C1-C4 alkyl; R8 is optionally substituted C1-C3 alkyl; R9 and R10 together with the nitrogen atom to which they are attached form an optionally su
Patent EC-SP961694-A (EC)
Title: Procedimeinto para preparar olanzapina (caso x - 9992m)
Inventor: HOTTEN TERRENCE MICHAEL
IPC: C07D235/14
Filed: 1996-03-21
Abstract: El invento se refiere a un nuevo procedimiento para preparar 2-metil-4-(4-metil-1-piperacinil)-10H-tieno[2,3-b][1,5] benzodiacepina (denominada en lo sucesivo con su nombre genérico "olanzapina") y a nuevos solvatos alcohólicos valiosos en este procedimiento, especilamente una forma de solvato monometanólico cristalino de un compuesto de la siguiente fórmula: (gráfico).
Patent EC-SP982672-A (EC)
Title: Antagonistas de receptores de vitronectina iii
Inventor: MILLER WILLIAM HENRY
IPC: C07C61/00
Filed: 1998-09-18
Abstract: Se describen compuestos de fórmula (I) que son antagonistas de receptores de vitronectina y son útiles en el tratamiento de osteoporosis: (gráfico), en la cual: A es Ch2 u o; R1 es H, halo o alquilo C1-6; R2 es H, alquilo C1-6 p Ch2NR¿¿R¿¿, X es 0 o CH2, Y es (gráfico), G es NR¿¿, SuO; R¿es H, alquilo C1-6, 0 alquilo C1-6, S-alquilo C1-6, Nr¿¿R¿¿ o halo; cada R¿¿es independientemente H alquilo C1-6; y o una sal farmacéuticamente aceptable de los mismos.
Patent EC-SP993234-A (EC)
Title: Composiciones de glifosato acuoso altamente concentradas
Inventor: WRIGTH DANIEL
IPC: C07F9/38
Filed: 1999-11-23
Abstract: Se proporciona una composición herbicida que comprende una solución acuosa de N-fosfonometilglicina, predominantemente en forma de sal de monoetanolamonio de la misma, a una concentración de aproximadamente 30% a 48% de equivalente de ácido de N-fosfonometilglicina en peso. En una realización particular, una composición herbicida comprende agua; N-fosfonometilglicina predominantemente en forma de sal de monoetanolamonio de la misma en solución en el agua en una cantidad de aproximadamente 360 a 570 g.a.e/l de la composición; y un componente tensioactivo en solución o dispersión estable en el agua, comprendiendo uno o mas tensioactivos en un monto total de aproximadamente 20 a 200 g/l de la composición, siendo seleccionado este componente tensioactivo de manera tal que la composición tenga un punto de turbidez no inferior a los 50oC.
Patent FI-20000735-A (FI)
Inventor: CASAIS EDUARDO
IPC: H04M1/72445
Filed: 2000-03-30
Abstract: A method of browsing interactive data services with a wireless mobile device using a multi-modal technique for selecting components of an image. The method of browsing is particularly useful with mobile devices operation in accordance with Wireless Application Protocol (WAP) but is not limited thereto. A first mode of selection includes overlaying an image over a grid of cells on the display of the mobile device such as a mobile phone (FIG. 2). The cells are matched to a corresponding key on the keypad of the mobile phone. The user selects the cell containing the portion of the image of interest for further browsing by pressing the appropriate key. The cell contains a pointer to, e.g. a universal resource locator (URL) on the Internet, related information for retrieval and display on the phone. A second mode of selection includes using vocal identifiers matched to specific cells on a voice recognition capable phone or network. When the user speaks a recognized identifier, it is matched to the appropriated cell which is then selected to display the desired information.
Patent FR-1108798-A (FR)
Inventor: MORRISON WILLARD LANGDON
IPC: F25J3/06
Filed: 1954-07-05
Granted: 1956-01-17
Abstract: 788,173. Liquefaction and revaporization of gases. CONSTOCK LIQUID METHANE CORPORATION. Jan. 31, 1955 [May 10, 1954], No. 2834/55. Class 8(2). Liquefaction of natural gas comprising mostly methane issuing at 2500 p.s.i. and 80‹F. from a well 1, Fig. 4, is effected by preliminary cooling in an exchanger 5 traversed by the gas having been expanded to 1000 p.s.i. at a valve 6 and freed from liquefied higher hydrocarbons which are collected in a separator 8, and then by cooling in an exchanger 12 freeing from carbon dioxide and water vapour in an amine contacter 14 and drier 17 expanding to just below atmospheric pressure and -259‹F. in a turbine 20 and collecting methane so liquefied in a separator 23 ; residual gas being recompressed and after cooled at 28 to 1000 p.s.i., cooled in an exchanger 26 to -95‹F. and added to the gas entering the turbine 20, which, assisted by a steam turbine 31 fed by a boiler 32 fired with some of the recompressed methane, serves to drive the compressor 28. The liquid methane is forced by a pump 35 through a duct 34 to a plurality of metal tanks 36, Fig. 1, loaded on a water-borne vessel 24 powered by an engine 68 running on methane vaporized from the tanks 36 and' stored in a chamber 66. To this end each tank has a balsa wood lining 37, Fig. 3, which conducts sufficient ambient heat to vaporize a portion of the liquid methane and which passes through a duct 49 to the storage chamber 66. Excess gas is vented to atmosphere through a valved port 46, a header 47 and a nozzle 62 of an injector supplied with air from a blower 65. Rapid vaporization of the liquid methane at the destination port is effected by a heating coil 42 and a superheater coil 43 in a closed circuit traversed by a low boiling point liquid forced from a reservoir 54a by a pump 50. The cold so removed from the tanks 36 by the circulating liquid serves to chill brine in a chamber 54 supplied by a pump 58 from a cold storage chamber 56. Blocks of solid carbon-dioxide at the bottom of each tank 36 provides an inert atmosphere during discharge of liquid methane. Reference has been directed by the Comptroller to Specification 766,128.
Patent FR-1604440-A (FR)
Title: Antiseptic impregnated support - contains resins gums or aromatics to purify enclosed air
IPC: A61L9/01
Filed: 1968-12-31
Granted: 1971-11-08
Abstract: Resins, gums and aromatic substances are hot or cold impregnated into porous or spongy supports which can be already impregnated with deodorants, bactericides or insecticides for purification of air in enclosed spaces e.g. disinfection of telephone receivers, cupboards. The impregnated products retain their purifying props for several months.
Patent GB-1047493-A (GB)
IPC: C10G73/00
Abstract: 1,047,493. Esters. ESSO RESEARCH & ENGINEERING CO. Jan. 28, 1964 [Jan. 30, 1963; June 3, 1963 (2)], No. 3650/64. Heading C2C. [Also in Division C5] Esters with molecular weight less than 950, are prepared by reacting a glycol with a dicarboxylic acid (12-14 C between the carboxylic groups) obtained by the polymerization of unsaturated mono-carboxylic acids, and are used as additives to lubricant compositions. Ethylene glycol, 4-oxa-heptane diol-2,6 and propylene, polypropylene and polyethylene glycols are mentioned and dimers of linoleic acid, or polymers of unsaturated fatty acids obtained as a still-residue in the manufacture of sebacic acid by the distillation of castor oil may be used as acids. Examples describe the preparation of esters of dimeric linoleic acid and ethylene, triethylene, neopentyl glycols and 1,4-butane diol, 1,6-hexane diol, and 1,12-dihydroxy octadecane to give oil-soluble esters.
Patent GB-1050412-A (GB)
IPC: H03H3/02
Abstract: 1,050,412. Piezo-electric elements. STANDARD TELEPHONES & CABLES Ltd. April 23, 1965 [April 24, 1964], No. 17028/64. Heading H1E. A support wire is attached to a piezo-electric element by depositing a thin film of metal (e.g. an electrode) on the element and soldering the wire thereto. The metal film contains chromium at least at its surface adjacent the element. The invention may be applied to the CT-cut quartz resonator 1 supported by wires 2 within an envelope 7. The cleaned crystal is heated to 300‹ C. in vacuo and thin films of nichrome deposited to form electrodes. The wires are attached at the centre by solder cones using activated flux in a stream of nitrogen. Damping weights 3 are applied to the wires which are attached to a supporting cage 4. The wires may consist of phosphor-bronze or berylliumcopper and the thin film of nichrome or pure chromium, preferably covered with gold. The thin film may cover only a small area of the crystal and the electrode proper may be deposited after attachment of the wire. The thin film thickness may be 800 Š for the nichrome and 2000 Š for the gold.
Patent GB-1225733-A (GB)
IPC: B62D55/27
Filed: 1969-03-17
Abstract: 1,225,733. Endless tracks. GERLACHWERKE G.m.b.H. 17 March, 1969 [16 March, 1968], No. 13919/69. Heading B7H. An endless track has adjacent track members connected by track pins 4, e.g. polygonal, and a beam 2, and is characterized by the overrun edges 7 of each track member (i.e. the transverse limiting edges of the wheel tracking surface thereof) and the axes of the track pins of each track member when projected downwardly being located inwardly of the edges 8 of track member tread portions 5, each beam forming part of the wheel tracking surface of the endless track. Each track member comprises two doubletubular bodies 1. Each beam is flexurally and torsionally stiff, being of a closed hollow section, and has end extensions 11 joined by plates 13 and an extension 9 formed as a fixed guidetooth. The top wall of the beam projects beyond side walls thereof to give a narrow overrun gap 16. The extensions 11 form tooth engagement spaces 12 and end-plates 13 give an almost continuous outer edge to the track. The bodies 1 have bushes 3 which are rubberized over their outer circumference and are for the reception of track pins 4. Ice-spikes or gripping bars can be arranged in the interspace between tread portions 5 being fastened detachably to the beam. The tread portion 5 could be replaced by steel ribs, with or without interchangeable running pads of rubber. The wheel tracking surfaces of the parts 1 and 2 could have rubber coatings.
Patent GB-1227298-A (GB)
IPC: B60T11/20
Filed: 1969-05-02
Abstract: 1,227,298. Brake master cylinders. GENERAL MOTORS CORP. 2 May, 1969 [21 May, 1968], No. 22487/69. Heading F2F. A dual master cylinder 16 for an hydraulic brake system comprises a primary piston 32 operatively movable by a brake pedal 10 to pressurize fluid in a chamber 36, a secondary piston 34 movable by fluid under pressure in chamber 36 to pressurize fluid in a second chamber 38, and a pressure sensitive locking device to cause the pistons 32, 34 to move together until the pressure of the fluid in chamber 36 exceeds a predetermined value, the locking device being in the form of a pressure sensitive detent 106 mounted for movement transversely of the piston 32 to engage in an aperture in a spring retainer 48 which contacts the face of piston 34. Primary piston 32 has a cross-pin 102 which moves in slots 104 in spring retainer 48 so that movement of piston 32 relative to the part 48 is permitted and is normally sufficient to pressurize fluid in the chamber 36 to cause detent spring 112 to be compressed and move the detent inwardly. If however there is no pressure in chamber 36 force is mechanically transmitted from the piston 32 and spring retainer 48 to the piston 34. In a modification the spring retainer extends into an axial bore in piston 32 and the two pistons are locked by a V-shaped spring catch. In further modifications the spring retainer is formed in two telescoping parts or telescopes over the end of the primary piston, locking being by means of ratchet teeth or cam operated detents.
Patent GB-1227974-A (GB)
IPC: G03B27/16
Filed: 1968-07-02
Abstract: 1,227,974. Lamp filters. H. SINGH. 2 July, 1968, No. 31620/68. Heading F4R. [Also in Divisions G2 and H1] A device particularly for use in colour photography for improving the balance of spectrally unbalanced light from a mercury discharge lamp comprises either a mixture of dyes which are coated upon, or incorporated into, the lamp envelope carrier or a combination of filters, the device selectively absorbing at least 25% of the emission at the wavelengths where peaks in intensity occur in the mercury discharge source spectrum. The combination of filters may comprise a magenta and yellow filter integrally associated to form a spectral transmission path, and the mixture of dyes may comprise magenta and yellow dye transfer dyes in the ratio 1: 1 to 2:5.
Patent GB-1228264-A (GB)
IPC: G06K7/04
Filed: 1969-07-10
Abstract: 1,228,264. Sensing records. SIEMENS A.G. 10 July, 1969 [11 July, 1968; 15 July, 1968], No. 34812/69. Heading G4M. A punched record 1 is sensed by spring-biased fingers 14 each carrying a blade 4 for interrupting the light path between a source 6 and a photo-detector 5. Fingers 14 are pivoted out of the record path during feed steps by a cam 8, and a latching device is provided for holding the fingers in the retracted position while a new record is inserted.
Patent GB-1229253-A (GB)
IPC: C07D513/04
Filed: 1968-06-26
Abstract: 1,229,253. Amine derivatives. ORGANON LABORATORIES Ltd. 26 June, 1968 [7 July, 1967], No. 56429/69. Divided out of 1,229,252. Heading C2C. Compounds of the general formula (R 1#2  = H, halogen, OH, acyloxy, C 1-6  alkyl or alkoxy, CFa; R 3 =H, C 1-6  alkyl, C 7-12  aralkyl, aminoethyl or aminopropyl optionally N-substituted by C 1-6  alkyl or C 1-6  alkyl and a nitrogencontaining heterocyclic group; R 4#5  = H or R 4+5 =further N-C bond; X=O, S, N(C 1-6  alkyl)) and their acid addition salts, quaternary ammonium compounds and N-oxides and the sulphoxides and sulphones of the thiazepines are prepared by reacting a compound of the formula with R 3 NH 2 , optionally followed by reduction and/or conversion to a salt, quaternary compound, N-oxide, sulphoxide or sulphone. The above compounds are sedatives, tranquilizers and antidepressants and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Patent GB-1229457-A (GB)
IPC: G01L21/00
Filed: 1968-04-09
Abstract: 1,229,457. Radio-meters. PHILIPS ELECTRONIC & ASSOCIATED INDUSTRIES Ltd. April 9, 1968 [April 10, 1967], No.17053/68. Headings G1L and G1X, In a thermomolecular pressure-measuring device comprising, inside an envelope within which the pressure is to be measured, a movable element 1, rotatable about an axis of symmetry and subjected to a mechanical couple due to impact, on part of the surface area, of molecules accelerated by impact on a hot surface of walls of a space 7, supported by an upwardly divergent magnetic field of revolution about a vertical axis and at least one body 302, 304 having magnetic properties, adjacent the element 1, spaced from the vertical axis the arrangement is such that the element 1 is caused to take up a predetermined orientation about the vertical axis with respect to the body or bodies 302, 304 by rotating the body or bodies 302, 304 about vertical axis 310, 312 so as to cause the element 1 to rotate about the vertical axis as the body or bodies are moved away from the element 1.
Patent GB-1229584-A (GB)
IPC: B60L5/00
Filed: 1967-05-01
Abstract: 1,229,584. Current collectors; gas cushion vehicles. HOVERCRAFT DEVELOPMENT Ltd. 23 April, 1968 [1 May, 1967], No. 20066/67. Heading B7L. An electric pick-up mechanism for an electrically powered rail vehicle, e.g. a gas-cushion supported vehicle powered by a linear induction motor, comprises a body of electrically conductive fluid 12, Fig. 1, supported in a chamber 2 of a structure 1 carried by the vehicle, which fluid is confined in contact with a conductor rail 14 by gas curtains 13 issuing from an outer annular chamber 7 surrounding the chamber 2. Fluid 12, e.g. mercury or water, is supplied to the chamber 2 by a pipe 4 and when the level reaches a terminal 5 current is supplied to a power line 6 in the vehicle. The pipe 4 is controlled by a valve (not shown) operated by level detecting means (not shown). In other embodiments a continuous circuit of liquid is maintained, with a portion of the circuit contacting the rail.
Patent GB-1238331-A (GB)
IPC: C09B1/20
Filed: 1968-03-25
Abstract: 1,238,331. Dyestuff intermediates. IMPERIAL CHEMICAL INDUSTRIES Ltd. 27 Feb., 1969 [25 March, 1968], No. 14269/68. Heading C2C. [Also in Division C4] The invention comprises anthraquinone compounds of the general formula wherein X is Cl or Br and the anthraquinone nucleus is substituted in at least one of the 4, 5, 6, 7 or 8 positions. In Examples 1 and 3, 1- hydroxy - 2 - hydroxy - methyl - 4 - bromoanthraquinone is chlorinated or brominated using thionylchloride or bromide in dioxane. The 2-chloromethyl or 2-bromomethyl compounds are precipitated, filtered, washed and dried.
Patent GB-1239511-A (GB)
IPC: C08G69/02
Filed: 1969-08-11
Abstract: 1,239,511. Polyamide. MONSANTO CO. 11 Aug., 1969 [15 Aug., 1968], No. 40005/69. Heading C3R. A linear polycarbonamide (P) contains at least 5% mole repeating units (d) The chain components (Q) all have terminal amide-forming gps. joined by a divalent hydrocarbon radical having #4C atoms. Units (d) maybe 1,4- or 1,3-cyclohexane-bis-(ethylamine); they may be in the cis and/or trans form. (P) may be derived from equimolar proportions of H 2 N-B-NH 2  and (T) HOOC-A-COOH. A may be naphthylene, anthrylene, -(CH 2 )4-20 or the above radicals in which one or more H- atoms are replaced by C 1 -C 4  alkyl, e.g. (k) where m is 0-4, is a cyclohexane or benzene ring, and Z is oxygen or (CH 2 ) m .(T) may also be terephthalic or phenylindene dicarboxylic acid. (Q) may also include or NH 2 -(CH 2 ) n -COOH, where n=4-14. (P) may be prepared by heating the components to 180-300‹ C. until intrinsic viscosity #0À4, e.g. at pressure below, equal to, or above atmospheric. Preferably the reaction is performed in the absence of O 2 , e.g. in N 2 . Also present may be stabilizers, pigments, anti-static agents, plasticizers, dyeability-altering additions, or delustrants. (P) may be melt-spun or used for moulding or coating.
Patent GB-1250611-A (GB)
IPC: C07D499/64
Filed: 1968-02-03
Abstract: 1,250,611. Ureido- and Thioureido-penicillins. BEECHAM GROUP Ltd. 31 Jan., 1969 [3 Feb., 1968; 14 Aug., 1968], Nos. 5574/68 and 38789/68. Heading C2A. Novel penicillins of the general formula and non-toxic salts thereof, wherein R is phenyl, substituted phenyl or thienyl; R<SP>1</SP> is alkyl, alkenyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, arylthio, aralkylthio or heterocyclic, and may be substituted; and Y is CO or SO 2 , are prepared by reacting an x-aminobenzylpenicillin or an x-aminothienylmethylpenieillin with an isocyanate or isothiocyanate of formula wherein R<SP>1</SP> and Y and X have the aforesaid meanings, in an organic solvent, and optionally converting the product to a non-toxic salt. Triethylamine is preferably present in the reaction mixture. The penicillins are active against Gram-positive and Gram-negative micro-organisms.
Patent GB-1250839-A (GB)
IPC: H05K3/22
Filed: 1969-05-02
Abstract: 1,250,839. Direct connections. INTERNATIONAL COMPUTERS Ltd. 5 May, 1970 [2 May, 1969], No. 22433/69. Heading H2E. A circuit board 10 has one or more holes 12 through the board and the electrical conductors 11 thereon, and one or more electrically conductive pins 8 inserted in corresponding holes, with insulating sleeves 9 of heat shrinkable material around the portion of the pin in the hole and a collar of solder 13 making electrical connection between the electrical conductor 11 and a portion of the pin 8 projecting through the circuit board whereby the electrical connection may be altered without withdrawing the pin from the hole. Thus, the solder 13 may be removed and a washer of insulating material 14 such as polytetrafluoroethylene placed on the pin 8a, thereby isolating the projecting end of the pin from the conductor 11a. A flying lead 15 may then be soldered to the projecting end of the pin without making electrical contact with the conductor 11a Said circuit board may consist of a plurality of layers of insulating material (17), (18) (Fig. 3, not shown) having conductive circuit patterns (16A), (16B), (16C) thereon. The holes (19) are through-plated with conductive material (20) to allow electrical connections to selected conductors at different layers in the multi-layer circuit board.