baber/WOPTO huggingface dataset:
Patent SG-11201811362V-A (SG)
Title: Maintenance therapy for the treatment of cancer
Inventor: LINDMARK BERTIL
IPC: A61P35/00
Filed: 2017-06-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI Organization 0 HIM 011101 0 0111111111111111H 10111111011110111111 International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/004465 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: A61K 31/51 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/SG2017/050333 (22) International Filing Date: 30 June 2017 (30.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1611580.0 01 July 2016 (01.07.2016) GB (71) Applicant: ASLAN PHARMACEUTICALS PTE LTD [SG/SG]; 83 Clemenceau Avenue, #12-03, UE Square 239920 (SG). (72) Inventor: LINDMARK, Bertil; c/o ASLAN PHARMA- CEUTICALS PTE LTD, 83 Clemenceau Avenue, #12-03, UE Square 239920 (SG). (74) Agent: STERLING IP PTE LTD; 10 Anson Road, #29-09, International Plaza 079903 (SG). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — — iln SO 71' 71' 0 C:::: ) (54) Title: MAINTENANCE THERAPY FOR THE TREATMENT OF CANCER --.... ,1 (57) : The present disclosure relates to a maintenance therapy for prolongation of remission of a cancer comprising adminis- CZ tering a therapeutically effective amount of a compound of formula (I), such as Varlitinib, or an enantiomer thereof, or pharmaceutically \" acceptable salt of any one of the same or a pharmaceutical composition thereof.
Patent SG-11201902974P-A (SG)
Title: Combination of a pd-1 antagonist and eribulin for treating urothelial cancer
Inventor: OLIVO MARTIN S
IPC: A61K31/357
Filed: 2017-10-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 01111H111111111111111111111111111111110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/071792 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61K 31/357 (2006.01) (21) International Application Number: PCT/US2017/056552 (22) International Filing Date: 13 October 2017 (13.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/408,328 14 October 2016 (14.10.2016) US (71) Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065 (US). EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 112-8088 (JP). (72) Inventor: OLIVO, Martin S.; 35 Franklin Turnpike, Al- _ lendale, New Jersey 07401 (US). = Agent: MEYER, Mercedes K. et al.; Drinker Biddle & (74) Reath LLP, 1500 K Street, N.W., Suite 1100, Washington, = District of Columbia 20005 (US). _ Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, _ KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = = = SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 .•!! Published: ei — with international search report (Art. 21(3)) cf , — with sequence listing part of description (Rule 5.2(a)) IN 1-1 IN 0 00 (54) Title: COMBINATION OF A PD-1 ANTAGONIST AND ERIBULIN FOR TREATING UROTHELIAL CANCER 1-1 0 (57) : The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor ei (PD-1) and eribulin or a pharmaceutically acceptable salt thereof, and the use of the combination therapies for the treatment of urothelial 0 cancer.
Patent SG-11201906963Q-A (SG)
Title: Binding agents
Inventor: FINLAY WILLIAM JAMES JONATHAN
IPC: C07K16/28
Filed: 2018-01-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT omit VIII °nolo oil! oinio oimIE (10) International Publication Number WO 2018/138521 Al (51) International Patent Classification: C07K 16/28 (2006.01) C07K 16/00 (2006.01) (21) International Application Number: PCT/GB2018/050239 (22) International Filing Date: 26 January 2018 (26.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701351.7 27 January 2017 (27.01.2017) GB 1713296.0 18 August 2017 (18.08.2017) GB (71) Applicant: ULTRAHUMAN ONE LIMITED [GB/GB]; c/o Kreston Reeves LLP, Innovation House, Ramsgate Road, Sandwich, Kent CT13 9FF (GB). (72) Inventor: FINLAY, William James Jonathan; c/o Kre- ston Reeves LLP, Innovation House, Ramsgate Road, Sand- wich, Kent CT13 9FF (GB). (74) Agent: ROBERTS, Michael Austin; Reddie & Grose LLP, The White Chapel Building, 10 Whitechapel High Street, London, Greater London El 8QS (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) M (54) Title: BINDING AGENTS 1-1 0, - -- 13 (57) : The invention relates to antibody molecules and antigen-binding portions thereof which bind specifically to glucocor- ,_ 1 ticoid-induced TNF receptor (GITR). In particular aspects of the invention, the antibody molecules specifically bind to human GITR and cynomolgus monkey GITR. The anti-GITR antibody molecules of the invention have been developed and optimized using CDR N sequences derived from a murine anti-GITR antibody 6C8. Medical uses of the antibody molecules are disclosed.
Patent IS-2926-B (IS)
Inventor: PEPINSKY BLAKE
IPC: A61K47/50
Filed: 2001-03-30
Abstract: An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
Patent AT-401061-B (AT)
Title: Use of a human monocytic cell line for the identification and determination of substances for inhibiting the human enzyme cyclooxygenase-2
IPC: C12Q1/26
Filed: 1995-01-26
Granted: 1996-06-25
Abstract: Method for the identification and quantitative determination of substances which inhibit the human enzyme cyclooxygenase-2, characterized in that a) cells of a non-genetically manipulated clone of the human cell line Mono Mac 6 are stimulated with suitable growth and/or differentiation factors, the cells stimulated in this way are incubated together with potential inhibitors of cyclooxygenase-2 and after addition of arachidonic acid the concentration or amount of the products of cyclooxygenase metabolism in the culture supernatant of these cells is measured using a suitable detection method, or b) cells of a non-genetically manipulated clone of the human cell line Mono Mac 6 are incubated with potential inhibitors of cyclooxygenase-2, these cells are then stimulated with suitable growth and/or differentiation factors, and after addition of arachidonic acid the concentration or amount of the products of cyclooxygenase metabolism in the culture supernatant of these cells is measured using a suitable detection method.
Patent AT-395553-B (AT)
Title: Apparatus for reprocessing scrap tyres
IPC: B29B17/02
Filed: 1991-03-19
Granted: 1993-01-25
Abstract: An apparatus serves for reprocessing scrap tyres under the effect of heat. To achieve a strict separation of the rubber from the steel inserts or the like, without having to fear any particular tool wear, the apparatus is designed as a centrifuge which can be charged from the top but can be closed. Its rotor 19, 20, 21, 22, which is provided with a screening cover 24 receives as centrifugate a stack of scrap tyres 23 kept at a distance from the screening cover 24 by axially parallel rods 21 or the like. This stack of scrap tyres surrounds a fixed heating element 14, a circulating stripper 10, transporting into a bottom outlet 6, being provided for the inside wall of the centrifuge. The interior space 7 of the centrifuge is vented by oxygen-free exhaust gas. <IMAGE>
Patent AT-403680-B (AT)
Title: Transportation device, in particular for local passenger transportation
IPC: B61B9/00
Filed: 1992-04-01
Granted: 1998-04-27
Abstract: Transportation device, in particular for local passenger transportation, having a plurality of conveying means 2 which are guided on a supporting element preferably along a continuous track, and having a plurality of stations 4 which are arranged along the supporting element, at least two, preferably more propulsion elements 2 being combined by means of connection devices 6 to form groups 1, and the conveying means 2 being moved in the stations 4 at a lower speed than between the stations 4. In order to increase the efficiency of the transportation device, there is provision for the stations to be on-line stations and for the length of the connection devices 6 to be variable. <IMAGE>
Patent AT-399095-B (AT)
IPC: G01N30/74
Filed: 1986-03-27
Granted: 1995-03-27
Abstract: A method of and apparatus for separating proteins adsorbed by ion-exchange gels, especially anion-exchanging gels includes at least one chromatographic column in which the protein-carrying gel is charged and is subjected to a gradient-elution with a buffer solution as eluant whose property is changed with time by gradually changing the ionic strength and maintaining a substantially constant pH value or by gradually changing the pH value and maintaining substantially a constant ionic strength. The obtained eluate is then fractionated into its various components.
Patent LT-3972-B (LT)
Title: Fermented milk product containing bifidobacteria and process for the preparation thereof
Inventor: ZAKEVIC VLADIMIR
IPC: A23C9/12
Filed: 1995-04-27
Abstract: This invention applies to the diary industry and can be utilised in the production of the pickled diary product, which is highly recommended for massive use for the purposes of health improvement and disease prevention for people of all age groups. The described method for the production of the pickled milk product includes the normalisation of primary raw materials, pasteurisation, cooling to a temperature of the pickling, processes of pickling by a sourdough of three bifid bacterium, ripening and packing. There are at least three types of bifid bacteria in the finished product, the concentration of each type of bacterium must be at least 10<8> of bacterium per 1 millilitre. The product has a wider range of actions against pathogenic micro organisms, than the products of the pickled milk, having bifid bacterium, known so far, because it includes the main types of bifid bacterium, that are found in the organisms of humans and high concentrations of these bacterium.
Patent LT-4328-B (LT)
Title: Method for testing condition of bulk material in a closed tank
Inventor: DOROSEVAS VIKTORAS
IPC: G01N22/00
Filed: 1996-07-05
Abstract: Invention belongs to a method of dry substances state non-destructive control in a closed container and is being used for diagnostics of their own state and physical-mechanical parameters, while keeping substances in various closed containers. Ultrasound pulse control method of substances state distinguishes itself by the fact, that in certain moments of time, frequency of which depends on specific features of the container surrounding environment (temperature, effect of dynamic forces of a building, container structure, etc.), it sends an ultrasound pulses in horizontal direction through the dry substance kept in a closed container and, depending on a ratio of their propagation speed in the top and bottom cross-sections of the container at the same base length and surrounding temperature, identifies the substance's state according to a special diagnostic control grid, set for the particular substance. Then it calculates it's physical and mechanical parameters analytically connected to longitudinal ultrasound wave propagation speed in the given state. The novelty of the method consists in the fact, that it determines longitudinal ultrasound wave propagation speed in a different cross-section of container. Besides it calculates an average speed and it's ratio in the top and bottom container cross-sections and measures a surrounding temperature. According to this, using a diagnostic bridge preset for particular substance states, it identifies the state of the substance. Afterwards it calculates certain physical and mechanical parameters of the identified state of particular substance. The parameters are analytically connected to propagation speed of longitudinal ultrasound waves in the given state. It enables not only control of dry substance in a closed container, but creates preconditions to achieve and maintain certain dry substance state with physical parameters of it's own.
Patent ZA-96367-B (ZA)
Title: Female component for refastenable fastening device
Inventor: BERGMAN CARL LOUIS
IPC: A61F13/62
Filed: 1996-01-17
Abstract: The present invention provides a refastenable fastening device including female fastening component preferably comprising a base web and an engaging layer. The base web comprises a structural elastic-like film (SELF) web and is joined to the engaging layer which comprises a plurality of filaments or a nonwoven web. The SELF web exhibits an elastic-like behavior in the direction of elongation without the use of added elastic materials. The SELF web includes a strainable network having at least two distinct regions comprised of the same material composition. The first region is oriented substantially parallel to an axis of elongation such that it will undergo a molecular-level deformation in response to an applied axial elongation in a direction substantially parallel to the elongation axis before a substantial portion of the second region undergoes any substantial molecular-level deformation. The second regions initially undergo a substantially geometric deformation in response to an applied elongation in a direction substantially parallel to the axis. The second regions include a plurality of raised rib-like elements which act in conjunction with the filaments or nonwoven web to provide a more effective female component with an increased ability to entangle the hooks of a complementary male component.
Patent AT-401570-B (AT)
Title: Method for controlling a blower-type gas burner
IPC: F23N5/18
Filed: 1992-10-02
Granted: 1996-10-25
Abstract: Method for controlling the mixture ratio of gas and air and the power of a modulating premixing blower-type burner, in which, for power-independent adherence to a specific mixture ratio of the volume flow, the command variable used is a differential pressure which is picked up via a throttle point in an air stream of the variable speed blower and which is used as an analog signal for power regulation, and in which, when a specific maximum permissible rotational speed nmax of the blower 3, dependent on the power of the burner 11, is reached, the burner 11 is switched off and is switched on again after a short time, and, below a specific differential pressure Wpx, the burner 11 is likewise switched off and started again after a specific time. So that, in the event of a change in the flow resistances, such a burner can still be operated reliably with the predetermined power, even when burner switch-offs take place, there is provision, when a specific number of switch-offs is exceeded within a specific timespan, for the burner 11 to be switched off with a locking effect. <IMAGE>
Patent AT-399071-B (AT)
IPC: H04J3/18
Filed: 1992-10-27
Granted: 1995-03-27
Abstract: PCT No. PCT/AT93/00165 Sec. 371 Date Jun. 1, 1995 Sec. 102(e) Date Jun. 1, 1995 PCT Filed Oct. 27, 1993 PCT Pub. No. WO94/10809 PCT Pub. Date May 11, 1994In an information transmission system, in particular a telephone system, the subscribers can be connected to a dial exchange over a line. At the dial exchange end and at the subscriber end of the line are connected bidirectional multiplexers or demultiplexers over a bidirectional modem circuit which modulates and demodulates the data according to the intended transmission. If required, bidirectional compressor and decompressor circuit are connected to the multiplexers and demultiplexers, to which the subscribers are connected through a forward and a backward channel and a SLAC (bidirectional analog-digital converter (CODEC) with subscriber interface circuits (SLIC)), or to which a relaying device of the dial exchange is connected through drive circuits. In order to allow fault finding to be carried out in a simple manner in such a system, a measuring, regulating or controlling circuit (33, 34, 36, 37, 38) is arranged between each subscriber (1) and their allocated CODEC, SLIC or SLAC (2) or is at least partially integrated into the CODEC, SLIC, SLAC.
Patent AT-397584-B (AT)
IPC: G01N22/00
Filed: 1989-12-29
Granted: 1994-05-25
Abstract: An arrangement determines amplitude and phase values of two signals of differing polarisation received by two separate receiving antennas, in particular signals in the micro-wave range, of a reflectometric measurement device. In order to obtain a simple design, the receiving antennas (5, 6) are connected with the inputs of a power divider (9, 19, 11, 12) and power combiner (13, 14), the four outputs of which are connected with detectors (20, 21, 22, 23). Two connectors directly receive the signals of an associated receiving antenna (5, 6) and the two other detectors receive a mix of such signals, one of the latter detectors (21, 22) receiving a mix of such signals the phase angle of one of which is rotated. A process for calibrating this arrangement is also described.
Patent DK-150900-B (DK)
Inventor: SARPANEVA TIMO
IPC: C03B19/02
Filed: 1981-05-29
Abstract: PCT No. PCT/FI80/00001 Sec. 371 Date May 13, 1981 Sec. 102(e) Date May 13, 1981 PCT Filed Oct. 24, 1980 PCT Pub. No. WO81/01142 PCT Pub. Date Apr. 30, 1981.A method for producing decorative glass objects in which the decoration is created by blisters formed by air bubbles within solid glass and/or by a pattern on the outer surface of the glass. When producing glass objects provided with air bubbles by means of known methods the bubbles remain on the surface of the objects which then easily break. In addition, the bubbles are formed at random, which may make them appear as dim impurities. When, in accordance with the invention, molten glass is poured from above in the shape of a band into a hot mould, the molten glass is spread into the mould in layers between which microscopic air bubbles remain. As the glass surface cools, the air enclosed within the bubbles expands in the molten glass which, while cooling, leaves the bubbles as clear pearls inside the glass. As the molten glass is spread in layers towards the wall of the mould, a pattern is formed as the glass surface cools.
Patent DK-164671-B (DK)
Inventor: JAENICKE OTTMAR
IPC: C07D501/36
Filed: 1986-12-02
Abstract: A process for the preparation of cefodizime of the formula   <IMAGE> +TR   <IMAGE>  wherein (a) a compound of the formula II (ATS) <IMAGE>   wherein R1 represents hydrogen or an aminoprotective group and A represents a hydrogen atom or one equivalent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first reacted with a compound of the formula III R-SO2Hal  wherein R represents an optionally substituted alkyl, aryl or aralkyl radical and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base, (b) a compound of the formula I (TACS)   <IMAGE>    in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appropriate, in the presence of a base, and (c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R1 present in the end product of the formula I is eliminated.
Patent FI-73515-B (FI)
Inventor: MANHART MICHAEL
IPC: B05B7/04
Filed: 1983-01-12
Granted: 1987-06-30
Abstract: The compressed-air supply line of the snow gun passes through the center of the pressurized-water supply line, thus bounding an annular chamber between them. Inner nozzles forming part of the air line interconnect the two supply lines. The compressed-air supply line opens out into an interior space within the spray head, this space being bounded at the front end by a perforated end piece. For the purpose of reducing the expenditure of energy for a given homogeneity of the air-water mixture, the radial width of the annular chamber in the vicinity of the inner nozzles is from one to three times greater than the diameter of an imaginary bore whose area corresponds to the total area of all inner nozzle bores, divided by three.