baber/WOPTO huggingface dataset:
Patent EP-0617038-B1 (EP)
Inventor: DEAN WILLIAM D
IPC: A61P43/00
Filed: 1994-02-08
Granted: 2001-09-05
Abstract: Carbonic anhydrase inhibitors, useful in the control of ocular hypertension, and having the formula: <CHEM> wherein: R1 and R2 are both chosen from H or C1-4 alkyl; R3 = C1-6 alkyl or CH2(CH2)nOR4 where R4=CH3 or (CH2)nCH3 and n = 1-4; or (CH2)nAr where Ar = unsubstituted phenyl, 3-methoxyphenyl, or 4-methoxyphenyl and n = 1 or 2. are prepared by displacing the C(2)-chloro of 3-acetyl- 2,5-dichlorothiophene with benzyl mercaptide to form the thioether of structure, which is then converted to 3-acetyl-5-chloro-2-thiophenesulfonamide by reaction with chlorine to form 3-acetyl-5-chloro-2-thiophenesulfenyl chloride, followed by reaction with ammonia to form 3-acetyl-5-chloro-2-thiophenesulfenamide, and finally oxidation. Bromination provides 3-bromoacetyl-5-chloro- 2-thiophenesulfonamide which is converted to (S)-3,4- dihydro-6-chloro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide by reduction with (+)- beta -chlorodisopinocampheylborane followed by treatment with aqueous base. Alkylation at N(2) provides the (S)-3,4-dihydro-6-chloro-4-hydroxy-2-substituted-2H-thieno[3,2-e]-1,2- thiazine-1, 1-dioxide. Formation of the C(6) anion is accomplished by halogen-metal exchange, and the anion is reacted with sulfur dioxide to form a lithium sulfinate, which upon reaction with hydroxylamine-O-sulfonic acid provides the (S)-3,4-dihydro-4-hydroxy-2-substituted-2H-thieno[3,2-e]-1,2-thiazine- 6-sulfonamide-1, 1-dioxide. Protection of the C(6)-sulfonamide functionality, followed by activation of the C(4)-hydroxyl and displacement with an appropriate amine provides the (R)-3,4-dihydro-4-alkylamino-2-substituted-2H-thieno[3,2-e]-1,2-thiazi ne-6-sulfonamide-1,1-dioxide.
Patent EP-0616807-B1 (EP)
Inventor: AXELSSON OSKAR
IPC: C07D487/06
Filed: 1994-03-11
Granted: 1998-07-08
Abstract: Compounds having the formula: <CHEM>  or a pharmaceutically acceptable salt thereof  wherein     R<3> is <CHEM> are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
Patent EP-0668825-B1 (EP)
Inventor: EMERSON JOHN KEIGHTLY
IPC: B41J2/125
Filed: 1993-11-16
Granted: 1997-03-26
Abstract: A multiple nozzle continuous ink jet printer has a common nozzle block (10) with an array of nozzles (1, 2, 3, 4, 5, 6, 7) having respective charge electrodes (12) operated by respective drop charging circuits (45, 46, 47, 48, 49, 50, 51). A pilot nozzle (34) is provided in operative proximity to the nozzles (1 to 7) to monitor and detect changes in phase due to changes in ink parameters such as temperature, viscosity and pressure. A phase selection means (42) is arranged to alter the clock phase (33) applied to the pilot nozzle drop charging circuit (44) responsive to a sensor means (38, 40) thereby maintaining optimal charging by the pilot charge electrode (36). During system initialisation the correct break-off phase relationship is established for each charge electrode (12). During printing the phase selection logic (25, 26, 27, 28, 29, 30, 31) for the printing array (1 to 7) is altered based on the alteration of the clock phase to the pilot nozzle (34).
Patent EP-0681449-B1 (EP)
Inventor: GOLDREYER BRUCE N
IPC: A61B5/308
Filed: 1994-01-05
Granted: 2004-10-13
Abstract: On procède à la cartographie de l'activation électrophysiologique dans le c÷ur humain pour des zones situées dans le myocarde en utilisant un cathéter (32) présentant au moins une paire de capteurs orthogonaux (34-46). Lesdits capteurs orthogonaux (34-46) qui sont constitués d'électrodes placées généralement sur la circonférence du cathéter (32), en des points longitudinaux donnés tous les 1-5 millimètres le long de ce dernier (32), reçoivent des signaux qui sont différenciés dans un amplificateur différentiel (50) afin de produire un signal indiquant seulement l'activité cardiaque biopotentielle localisée en un point déterminé dans le myocarde. Les capteurs orthogonaux (34-46) sont adjacents à la pointe de stimulation (58) du cathéter (32) de manière à permettre la détection de l'activité cardiaque localisée en un point adjacent à la pointe ou en contact avec celle-ci, pendant la procédure de stimulation ou la libération d'énergie durant l'ablation. La détection de l'activité localisée survient en même temps que la stimulation ou l'ablation de sorte que les électrocardiogrammes du tissu stimulé ou soumis à l'ablation peuvent être enregistrés.
Patent EP-0693148-B1 (EP)
Inventor: SCHULTE HEINZ-GUENTHER
IPC: D21H21/02
Filed: 1994-03-30
Granted: 1997-05-21
Abstract: The invention relates to a process for controlling the deposition of stickies from paper stock suspensions in papermaking. According to the invention, the deposition of stickies is controlled by addition of an effective quantity of a degradation product of native starch to the paper stock suspension.
Patent EP-0695171-B1 (EP)
Inventor: SKRABANJA ARNOLD TITUS PHILIP
IPC: A61K38/24
Filed: 1994-04-25
Granted: 1996-12-18
Abstract: PCT No. PCT/EP94/01303 Sec. 371 Date Jun. 5, 1995 Sec. 102(e) Date Jun. 5, 1995 PCT Filed Apr. 25, 1994 PCT Pub. No. WO94/25005 PCT Pub. Date Nov. 10, 1994The invention relates to lyospheres comprising gonadotropin, the preparation thereof, as well as pharmaceutical preparations containing the same.
Patent EP-0696304-B1 (EP)
Inventor: WISSMANN ROLF BERNHARD
IPC: C08K7/14
Filed: 1994-04-28
Granted: 1998-03-04
Abstract: La présente invention se rapporte à une composition polymère comprenant: (a) un premier polyamide préparé à partir d'un constituant à base d'acide carboxylique aromatique et d'un constituant à base de diamine aliphatique, le constituant diamine aliphatique étant un mélange de diamine d'hexaméthylène et de diamine de 2-méthyle 1,5-pentaméthylène; (b) un second polyamide choisi entre un polyamide aliphatique, un polyamide semi-aromatique et des mélanges ou combinaisons de ceux-ci; et (c) une charge de remplissage minérale. Ces compositions polymères présentent une température de transition vitreuse Tg ne dépassant pas environ 117 °C, et une température de crête de cristallisation à froid Tcc comprise entre environ 145 °C et 160 °C. Des articles moulés fabriqués à partir de ces compositions présentent un bon aspect de surface.
Patent EP-0717670-B1 (EP)
Inventor: ERICKSSON HAKAN
IPC: B23G5/02
Filed: 1994-09-07
Granted: 2000-03-22
Abstract: A thread cutting insert comprises a center portion and a plurality of cutting corners project outwardly from the center portion. Each cutting corner comprises a pair of outwardly converging cutting edges which are joined together by a curved tip. Each cutting corner includes a chipbreaking protrusion extending upwardly higher than the upper face of the center portion of the insert. The protrusion includes a front portion facing the tip, and a pair of upwardly converging sides. The front portion and sides are spacially confined to the cutting corner.
Patent EP-0726736-B1 (EP)
Inventor: FARRIS BARRY
IPC: A61M5/28
Filed: 1994-11-02
Granted: 2003-04-09
Abstract: A syringe which has been prefilled to include a prescribed liquid and also a gas. The syringe includes a reservoir, a chamber which is in fluid communication with the reservoir and an outlet which is interposed between the chamber and the reservoir. Severing the chamber from the reservoir at the outlet will provide a syringe that includes a reservoir and an outlet. Prior to severing the chamber from the reservoir, the syringe may first be oriented such that all gas is directed into the chamber so that the syringe's reservoir will be completely filled with non-compressible fluid such as the medicating liquid.
Patent EP-0668293-B1 (EP)
Inventor: KALBE DR JOCHEN
IPC: C08B31/16
Filed: 1995-02-03
Granted: 2000-09-20
Abstract: Novel thermoplastic, biodegradable polysaccharide ether-ester derivs. are of formula (I): Polysaccharide-O-R (I); Polysaccharide-O- = the substd. OH gp. of a polymeric saccharide unit; R = monomeric and/or polymeric substit. of structure X, Me or (depending on the substitution degree per saccharide unit with X or Me) H; X = -A-B-A'-; A, A' = linear polyether chains, where A = (-D-O)n; and A' = (-D-O)mH; D = linear aliphatic or linear or branched aromatic chain of 2-11C; n = 0 or more; m = 1 or more; B = -CO-E-CO-O-; E = opt. substd. aromatic or aliphatic hydrocarbyl; ratio of A' to B is 0.1 or more.
Patent EP-0668269-B1 (EP)
Inventor: CASADO MICHEL
IPC: C07D231/38
Filed: 1995-02-17
Granted: 2002-05-29
Abstract: Process for the sulphinylation of heterocyclic cpds. comprises reaction of a deriv. of formula RS(O)X with a heterocyclic cpd. Het. R = 1-4C alkyl (opt. substd. by one or more halo); X = halo, hydroxy(or one of its salts), -NR2R3 or aryloxy; R2, R3 = 1-4C alkyl or haloalkyl; aryl = pref. phenyl (opt. substd. by one or more halo or 1-4C alkyl or haloalkyl); Het = a pyrrole, pyrazole, imidazole, oxazole, iso-oxazole, isothiazole, thiazole or triazole (all opt. substd. by one or more halo, amino, mono- or di-alkylamino, nitrile or aryl (opt. substd. by one or more halo and/or one or more alkyl, haloalkyl or SF5); provided that R is not n-butyl when Het = pyrrole and R is not methyl when Het = 2,5-dimethyl pyrrole. Intermediates RS(O)NH-Het are new.
Patent EP-0679354-B1 (EP)
Inventor: BUETTNER-WINDEMUTH BRIGITTE
IPC: A47G19/16
Filed: 1995-04-21
Granted: 1998-09-23
Abstract: The disposable tea bag has two flat sections (1, 1') which are pressed together before use. Each section (1, 1') has a stiffening strip (10) at their upper edges (4, 4') extending from one side edge to the other edge (2). Pressure against both sides of the stiffening strip, at the upper edges (4, 4') of the bag, causes each to bend away from the other to be spread apart. <IMAGE>
Patent EP-0685395-B1 (EP)
Inventor: BLIDUNG OTTO
IPC: B65B43/12
Filed: 1995-05-20
Granted: 1998-07-22
Abstract: The blank loading system has a transfer path (4), for moving the packaging blank stacks (2) from a pallet station (3), provided by a pair of separately driven conveyors (16, 17), coordinated to allow uninterrupted feeding of the blanks to the machine when the pallet is being changed. A feed-on system supplies a greater number of blank stacks to the conveying path per unit of time than are removed from it by a delivery conveyor (7) at the packaging machine end, with the stacks divided between the parallel conveyors, so that either conveyor provides the required number of stacks for the packaging machine. <IMAGE>
Patent EP-0693699-B1 (EP)
Inventor: WINTERHOFF HANS DIPL-ING
IPC: G02B6/44
Filed: 1995-07-03
Granted: 1999-12-01
Abstract: The device has a clamp (13) with a U-shaped clamp element (7) securing the central element (3) of the optical cable (1), in cooperation with a sliding sleeve (8), fitted around the outside of the clamp element. The clamp element is secured to a fixing element (6) for the clamp via an intermediate element (5). The fixing element is used to secure the clamp to a fixing (11), clamped to the cable end (4) and to a fixing plate (12). The opening width of the U-shaped clamp element is adjusted to match the dia. of the optical cable central element, with a lipped edge (16) at the end of one arm bent inwards towards the central element. <IMAGE>
Patent EP-0770825-B1 (EP)
Inventor: KULBACH EGON
IPC: F24C3/12
Filed: 1995-10-23
Granted: 2000-04-26
Abstract: The gas burner has a mechanically operated gas feed control, for automatically controlling the opening and closing of the gas supply to the gas burner (1) in response to the movement of the burner grid (12) due to the weight of a cooking pan being placed on it or lifted off. The movement of the burner grid operates an electric microswitch (6) controlling a magnetic valve (9) inserted in the gas feed line to the burner.
Patent EP-0715021-B1 (EP)
Inventor: DAHL JOHANNES DIPL-ING
IPC: E01B3/40
Filed: 1995-10-28
Granted: 1998-10-07
Abstract: The system includes a concrete track plate which consists of two layers formed one on the other, and between which is located a reinforcement made of reinforcing rods which run in the track direction and at right angles to it. The concrete of the layers of the track plate is materially bonded into the reinforcement mesh. The retaining units are constructed as rail support point elements which are connected into the upper layer of the concrete track plate and are anchored in both layers by reinforcing components.
Patent EP-0712882-B1 (EP)
Inventor: ABUSLEME JULIO A
IPC: C08L71/02
Filed: 1995-10-30
Granted: 2000-04-26
Abstract: Microemulsions are described which comprise:     (a) water; (b) a fluoropolyoxyalkylene having hydrogenated end groups and/or hydrogenated repetitive units; (c) an hydrocarbon C1-C20, preferably C1-C12, of aliphatic, aromatic, or mixed type, optionally containing halogens, preferably chlorine and/or bromine;   (d) a fluorinated surfactant. Such microemulsions can be used in radical (co)polymerization processes in aqueous emulsion of one or more fluorinated olefinic monomers, optionally in association with one or more non fluorinated olefins.
Patent EP-0663738-B1 (EP)
Inventor: BAYART DOMINIQUE
IPC: H04J14/00
Filed: 1995-01-11
Granted: 2002-10-02
Abstract: The method includes dividing amplifier gain between several multiplexed carrier waves. The desired division is maintained when the number and/or power of the carrier waves move away from predetermined values. The power of the amplified light is independent of the carrier waves and the gain division gives the same amplification to all the carrier waves.  An amplified laser light is passed to a coupler (16) which detects the power from a fibre optic amplifier (10). The signal is optically filtered (24) and passed to a photodiode (18). A voltage level output from the photodiode is input to an amplifier (20) and regulator (22). Signals from the regulator pass to two laser pumps (12,14). Varying the voltage input to the laser pumps adjusts gain to the overall level required for the channels used.
Patent EP-0676218-B1 (EP)
Inventor: VAN DEN BERGH HUBERT PROF DR
IPC: G02B6/245
Filed: 1995-03-16
Granted: 2002-06-12
Abstract: A light diffuser (1) for the radial emission of light, which has been fed into the diffuser in axial direction, comprises an optical waveguide (2), which itself comprises a core (20) and a cladding (21). The core of the waveguide is exposed at an active region (200) at the distal end (201). The exposed active region (200) of the core (20) is optically separated from a substance containing scattering particles. In a preferred embodiment, the core (2) is roughened and is embedded in a first layer (3) of an elastic substance, which has a refreactive index similar to the refractive index of the cladding (21) and which does not contain any scattering particles. This first layer (3) is embedded in at least one further, second layer (4) of an elastic substance comprising the scattering particles (40). This substance is surrounded by the outer tube (5). <IMAGE>
Patent EP-0756005-B1 (EP)
Inventor: NAKAMURA SEIJI
IPC: A61K48/00
Filed: 1994-12-27
Granted: 2005-03-09
Abstract: A DNA containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:4 or 5 in Sequence Listing, which optionally has partial replacement, deletion or addition, or a base sequence hybridizable therewith; a recombinant vector containing this gene; a transformant constructed by using this vector; a process for producing adseverin by using the above-mentioned gene; a recombinant adseverin protein obtained by this production process; an oligonucleotide hybridizable specifically with a base sequence encoding an amino acid sequence represented by SEQ ID NO:4 or 5; a method for regulating the formation of adseverin in an animal which comprises administering the above-mentioned oligonucleotide to the animal; and an antibody capable of recognizing adseverin protein.
Patent EP-0740770-B1 (EP)
Inventor: DASSLER HANS-ULRICH
IPC: G01B11/24
Filed: 1995-01-12
Granted: 1999-04-28
Abstract: PCT No. PCT/DE95/00036 Sec. 371 Date Jul. 17, 1996 Sec. 102(e) Date Jul. 17, 1996 PCT Filed Jan. 12, 1995 PCT Pub. No. WO95/19542 PCT Pub. Date Jul. 20, 1995An apparatus and a method are presented in order to carry out an automatic optical inspection of an off-center rotating component to be measured. Using a measurement procedure which avoids mechanical contact having a source producing parallel rays and a detecting means, the off-center rotating component is rotated about a rotational axis, whereby a motion of the detecting means is synchronized with the rotation and is carried out in such a fashion that the separation, in the direction of an optical axis, between the off-center rotating component and the detecting means remains constant. In this manner optical distortions are avoided which would otherwise occur in the optical measurement procedure.
Patent EP-0757703-B1 (EP)
Inventor: SCHNAEBELE JUERGEN
IPC: C08J5/18
Filed: 1995-04-08
Granted: 1999-08-11
Abstract: The invention concerns a foil for covering goods carriers such that they can be handled more securely, so replacing the known aluminium cover foils. The foil comprises a plastics matrix which contains a particulate filler, the filler being selected and present in the matrix in such a quantity that the resistance to piercing of the foil is reduced to a limit of less than 450 N/mm (measured on an approximately 150  mu m thick foil). A highly crystalline polypropylene is used as the plastics matrix material.
Patent EP-0730566-B1 (EP)
Inventor: CHAMBERS RICHARD DICKINSON
IPC: C07C22/08
Filed: 1995-07-26
Granted: 2001-09-19
Abstract: A process for the preparation of a selectively fluorinated organic compound, which process includes reaction of a precursor of said organic compound, the precursor containing at least one Group VI element selected from sulfur, selenium and tellurium, with a fluorinating agent and another halogenating agent and characterised in that the fluorinating agent is elemental fluorine.
Patent EP-0784719-B1 (EP)
Inventor: JANNACH HELMUT
IPC: D06F58/00
Filed: 1995-10-04
Granted: 1999-09-15
Abstract: PCT No. PCT/AT95/00192 Sec. 371 Date Jun. 30, 1997 Sec. 102(e) Date Jun. 30, 1997 PCT Filed Oct. 4, 1995 PCT Pub. No. WO96/10670 PCT Pub. Date Apr. 11, 1996The invention relates to a device for drying protective suits, for which the suit is put over a supporting framework, which consists of tubes and reaches into all extremities of the suit, the tubes having outlet openings at their ends for warm air that has been blown in. The supporting framework 1; 101 is formed by tubular hoops 2, 3, 4, 5; 102, 103, 104, 105; 102', 103', 104', 105' which, in the area of the feet and hands of the protective suit, have bends 6, 7, 8, 9; 106, 107, 108, 109; 106', 107', 108', 109', in which the outlet openings 21; 121 for the drying air are disposed. An additional connecting piece 124; 124', which optionally can be shut off, is provided at the common manifold 18, 118, 118' for supplying detergents and disinfectants, it being possible preferably to shut off the drying air line before the connecting piece 124 also by means of a valve 125.
Patent EP-0789947-B1 (EP)
Inventor: FERNANDEZ JOSE M
IPC: H02J7/00
Filed: 1995-10-04
Granted: 2000-08-30
Abstract: A battery pack (12) for powering a device (14) sensitive to input voltage contains a protection switch (28) and a control circuit (26). When the battery pack (12) is charged by a charger (10) and the voltage of the battery pack approaches the maximum safe level of the device (14), the control circuit (26) causes the protection switch (28) to electrically switch open to protect the device (14) from excessive voltage potentially output by the charger. Where the cells (16) are lithium ion cells or a type having a maximum safe voltage, a safety switch (49) is included to interrupt charge current (52) through the cells (16). The safety switch (49) is delayed by resistor/capacitor network (51, 53) so that it switches after the protection switch (28). The safety switch (49) includes a diode (58) to allow the device (14) to remain powered while the safety switch is blocking charge current. Further, diodes (40 and 42) are required to eliminate measurement error of the control circuit (26) if the battery pack (12) is charged through the device contacts (20 and 24).
Patent EP-0791007-B1 (EP)
Inventor: MARTIN JOSE JULIO
IPC: C12R1/645
Filed: 1995-11-06
Granted: 1999-08-11
Abstract: Sordarin derivatives of formula (I) <CHEM> have antifungal activity.l
Patent EP-0784469-B1 (EP)
Inventor: SANTIAGO NOEMI B
IPC: C07C235/84
Filed: 1995-10-16
Granted: 2004-03-24
Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
Patent EP-0796356-B1 (EP)
Title: Method of applying phosphate coatings to metal surfaces
Inventor: WENDEL THOMAS
IPC: C23C22/36
Filed: 1995-12-05
Granted: 1998-11-04
Abstract: PCT No. PCT/EP95/04774 Sec. 371 Date Jun. 6, 1997 Sec. 102(e) Date Jun. 6, 1997 PCT Filed Dec. 5, 1995 PCT Pub. No. WO96/17977 PCT Pub. Date Jun. 13, 1996A method is disclosed for applying phosphate coatings to surfaces of zinc, iron, aluminum, and the alloys thereof by wetting with a phosphatizing solution containing divalent cations and phosphate to form a liquid film, and subsequently drying on the liquid film wherein the metal surfaces are wetted with a phosphatizing solution, which is free from elements of sub-groups 5 and 6 of the Periodic Table, said phosphatizing solution containing: 0.5 to 8 g/l nickel; 2 to 20 g/l manganese; 18 to 170 g/l of phosphate (calculated as P2O5); and has an acid number of 0.4 to 0.8, such that after drying on, a phosphate layer having a weight per unit area of 0.3 to 3.0 g/m2, is obtained, where in the case of phosphatizing surfaces of iron, aluminum or the alloys thereof, the phosphatizing solution necessarily contains 0.5 to 5 g/l of zinc, and in the case of phosphatizing surfaces of zinc or zinc alloys the phosphatizing solution either contains zinc or is free from zinc.
Patent EP-0797427-B1 (EP)
Inventor: LANZENDOERFER GHITA
IPC: A61K31/70
Filed: 1995-12-12
Granted: 2003-05-14
Abstract: Cosmetic and dermatological compositions for the treatment or prophylaxis of hyper-reactive or deficient, hypoactive skin, contain active agents (I) which are at least one flavonoid or a combination of flavonoid(s) with cinnamic acid derivative(s) and optionally other conventional active agents. <??>Cosmetic and dermatological compositions for the treatment or prophylaxis of hyper-reactive or deficient, hypoactive skin, contain active agents (I) which are at least one flavonoid or a combination of flavonoid(s) with cinnamic acid derivative(s) and optionally at least one of antioxidants, endogenous energy source metabolites, endogenous enzymatic antioxidant systems or their synthetic derivatives (mimics), antimicrobial or antiviral agents and other conventional active agents.
Patent EP-0738865-B1 (EP)
Inventor: BORCHERS INGO U DR
IPC: B64G1/00
Filed: 1996-01-30
Granted: 2000-08-23
Abstract: The absorber has a chamber with a base (11) and side walls (12), and an upper part. The upper part has a horn (2), a permeable cover layer (3) and a diaphragm (4) connecting the horn to the side of the chamber. The horn projects into the bottom part (1) of the chamber and tapers in the direction of the base. Slots (5) in the neck of the horn can be added to improve the absorption effect. Undesired noise incident on the upper part of the absorber is effectively reduced by direction of the flow to the neck, where it undergoes flow separation between the neck of the horn and the base of the chamber.