baber/WOPTO huggingface dataset:
Patent CA-2182877-A1 (CA)
Title: Pharmaceutical piperazine compounds
Inventor: BROCCHINI STEPHEN JAMES
IPC: A61P7/02
Filed: 1995-02-14
Abstract: A diketopiperazine of formula (A), wherein one or both of R1 and R2, which may be the same or different, is: (I) X, or a phenyl group which is substituted by X, C(O)X, OC(O)CH2X, OCH2CH2X, CH2X, CONH(CH2)nX, O(CH2)nCH(OH) (CH2)nX or (a) or which is fused to a group X; (II) a phenyl group substituted by CH2NR12R13, OC(O) (CH2)nZ, CH(OR12)(OR13), (CH2)nNR14C(O) (CH2)mNR12R13 or O(CH2)nCH(OH) (CH2)nN(R12R13); (III) a group CH=C(W)V; or (IV) a cyclohexyl group; and where appropriate, the other of R1 and R2 is a phenyl group optionally substituted by one or more groups independently selected from halogen, nitro, methoxy, NHC(O)R12, CO2H, O(CH2)nN(R12R13) and CH2Y(CH2)nN(R12R13); R3 is C1-C4 alkyl or (CH2)nC(O)OR12; Y is O or S; Z is a C3-C6 cycloalkyl group; W is hydrogen or a phenyl group; and the pharmaceutically acceptable salts and esters thereof having activity as inhibitors of plasminogen activator inhibitor.
Patent CA-2183759-A1 (CA)
Title: Preboot protection for a data security system
Inventor: MOONEY DAVID M
IPC: G07F7/00
Filed: 1995-03-01
Abstract: A secure computer controlling access to data storage devices via a card reader. A microprocessor-controlled card reader inter-face logically connected to the card reader and the central processing unit (CPU) of the computer reads and writes information from and to a card placed in the card reader and performs additional functions in response to commands received from the CPU. The card reader interface includes an encryption en-gine for encrypting data in a data storage device and a boot ROM containing verifica-tion program code executed during an ini-tialization procedure. The verification pro-gram verifies that a valid user card has been placed in the card reader, reads one or more questions from the user card, asks the ques-tions of the user and verifies the answers against the contents of the card. If autho-rization is verified, the card reader interface permits the user to access the encrypted data. Otherwise, the user is denied access to the data by one or more of the following meth-ods: freezing the system bus, and requiring the user to reset the computer and re-enter the verification program; logically destroy-ing the data in the data storage devices; and physically destroying the data storage de-vices.
Patent CA-2184588-A1 (CA)
Title: Rouleau de couchage par gravure et procede permettant d'obtenir un gradient de revetement uniforme
Inventor: FIELDS THOMAS R
IPC: B41F13/11
Filed: 1995-03-03
Abstract: Rouleau de couchage par gravure et procédés de revêtement associés produisant un gradient de revêtement uniforme sur un substrat. Ce rouleau de couchage par gravure comprend une série de cellules disposées dans des parties à densité linéaire circonférentielle dans lesquelles les densités linéaires augmentent progressivement d'une partie à l'autre, les volumes des cellules diminuent progressivement dans chaque partie et les volumes des cellules à la fin d'une partie sont sensiblement identiques aux volumes des cellules au début de la partie adjacente suivante.
Patent CA-2184813-A1 (CA)
Title: Wound Disinfection and Repair
Inventor: KROSS ROBERT D
IPC: A01N59/00
Filed: 1995-03-01
Abstract: Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments.
Patent CA-2187860-A1 (CA)
Inventor: GUESDON PHILIPPE
IPC: C23C2/26
Filed: 1996-10-15
Abstract: Procédé de traitement d'une couche métallique de revêtement de tôle dans lequel on projette une poudre sur ladite couche métallique lorsqu'elle est, au moins partiellement, à l'état liquide, ladite poudre étant préparée par atomisation de manière à se présenter sous forme d'agglomérats de taille moyenne supérieure à l'épaisseur de ladite couche métallique à l'état liquide. Cette poudre à projeter permet de traiter des couches métalliques (à l'état fondu) plus facilement et de manière très homogène, même lorsqu'elle contient plusieurs types de composants.
Patent CA-2190850-A1 (CA)
Title: Handle pallet for implements such as sports racquets
Inventor: DAVIS STEPHEN J
IPC: A63B49/08
Filed: 1996-04-03
Abstract: A sports racquet, e.g. a tennis racquet, has an elastomeric pallet that slides onto the racquet shaft. The pallet is formed preferably with a pair of opposed axially extending guides (46) formed on opposed interior surfaces of the pallet. Each guide defines a pawl member (47). The racquet shaft includes a pair of guide grooves (58). to receive a respective guide and pawl member, and each groove contains a mating ratchet member. When the pallet slides on the shaft. the guides slide along the guide grooves, until the pawl members and ratchet members engage, which locks the pallet at a predetermined position on the shaft against reverse movement. Due to the fact that the pallet can be easily mounted on the shaft, without the need for adhesive or mechanical fasteners, retailers can cam, separate inventories of pallets and racquet, and the customer can select the desired pallet model and handle size at the time of purchase.
Patent CA-2190986-A1 (CA)
Inventor: HARDEN PHILIP ALAN
IPC: A01F12/26
Filed: 1996-11-21
Abstract: The invention is directed to a concave for a rotary crop processing unit for an agricultural combine. The concave comprises a frame to which is releasably mounted a grid. The grid comprises a plurality of curved rods to which are projection welded a series of straight bars. The bars are perpendicular to the rods. The grid is held in place by a mounting assembly which is formed by six mountingears that are welded to the frame that clamp the grid against a curved rim. A trapping lip is also used to trap one end of the grid in the frame.
Patent CA-2191077-A1 (CA)
Inventor: FORSSEN ERIC
IPC: A61K9/133
Filed: 1995-06-27
Abstract: A liposome formulation containing a vinca alkaloid and an anion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholesterol and distearoylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.
Patent CA-2192389-A1 (CA)
Title: Novel farnesyl transferase inhibitors, their preparation and pharmaceutical compositions containing same
Inventor: BAUDOIN BERNARD
IPC: A61P43/00
Filed: 1995-06-07
Abstract: Novel farnesyl transferase inhibitors of general formula (I), their preparation and pharmaceutical compositions containing same. In general formula (I), R1 is Y-S-A1 -(Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl radical or an R4-S radical in which R4 is an alkyl radical containing 1-4 carbon atoms optionally substituted by a phenyl radical or a radical of general formula (II), in which A1, X1, Y1, R'1, R2, R'2 and R are defined as follows: A1 is an alkylene radical containing 1-4 carbon atoms optionally a substituted at  alpha  in the grouping >C(X1)(Y1) with an amino or alkylamino, dialkylamino, alkanylamino or alkoxycarbonylamino radical), X1 and Y1 are each a hydrogen atom or form together with the carbon atom to which they are connected a >C=O grouping, R'1 is hydrogène or methyl, R2 is an alkyl, alkenyl or alkynyl radical containing 1-6 carbon atoms optionally substituted by hydroxy, alkoxy, mercapto, alkylthio, alkylsulfinyl or alkylsulfonyl, with the proviso that when R2 is an alkyl radical substituted by a hydroxy radical, R2 can form a lactone with the carboxy radical at  alpha . R'2 is hydrogen or methyl and R is a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted phenyl radical, whith the proviso that the radical (a) is in position 5 or 6 of the naphthyl ring. These novel products have anti-cancer properties.
Patent CA-2193715-A1 (CA)
Title: Dispositif electrique a commutation d'arc
Inventor: ABOT JEAN
IPC: H01H89/06
Filed: 1996-12-20
Abstract: Dispositif électrique à commutation d'arc Le dispositif est a double coupure et une électrode 20 de transfert d'arc, à laquelle est associe le chemin 21 de dérivation shuntant l'organe à protéger 33, est disposée au voisinage du contact fixe amont 13A. <IMG>
Patent CA-2193930-A1 (CA)
Inventor: WETZEL UWE
IPC: F16K31/06
Filed: 1996-12-24
Abstract: A control device for controlling and monitoring two fluid valves, wherein each fluid valve comprises a drive means which is adapted for activation by an associated control signal, and a movable valve element which is biassed toward a first position in which fluid flow through the valve is prevented and which can be driven by said drive means to a second position in which fluid is able to flow through the valve, a first switch which is actuable by the displaceable element of the first valve, a second switch which is actuable by the displaceable element of the second valve, wherein each switch is biassed towards a first position and each switch can be driven to a second position when the displaceable element of the associated valve takes its second position.            According to the invention,  both switches (Z0,  Z1)  are adapted to directly influence the control signal paths in both switch positions and are connected in a manner to prevent application of the first control signal (S1) to the first valve (20) with the first valve in its first position when application of the first control signal (S1) takes place after a predetermined time period has lapsed from the time of activating of the second valve, and to prevent application of the second control signal (S1) to the second valve when in its first position if the application of the second control signal (S2) takes place after a predetermined time period has lapsed subsequent to activation of the first valve. Both switches (20, 21) are connected in a manner to permit each control signal to be applied to a respective drive means when both switches simultaneously occupy their first position or simultaneously occupy their second position.
Patent CA-2195403-A1 (CA)
Inventor: TORCZYNSKI RICHARD M
IPC: C07K14/47
Filed: 1995-07-19
Abstract: Cette invention se rapporte à une séquence d'acides nucléiques isolée et purifiée et à sa séquence d'acides aminés correspondante, qui codent pour une nouvelle protéine spécifique des cellules du cancer des poumons chez l'homme. Ce gène est exprimé dans ces cellules à un niveau beaucoup plus élevé que dans les cellules des poumons normales, dans d'autres tissus normaux et dans d'autres lignées de cellules tumorales ayant été testés. Cette invention se rapporte également à trois formes recombinées supplémentaires de ce gène et de cette protéine, où, dans les deux premiers cas, une région transmembranaire est retirée et, dans le troisième cas, un acide aminé est modifié par mutagénèse in vitro. Cette invention décrit également des sondes d'acides nucléiques servant à détecter des cellules du cancer des poumons dans une biopsie tissulaire et dans des fluides corporels, tels que le sérum, les crachats et les lavages bronchiques. Un procédé pour exprimer cet antigène dans une cellule hôte et son utilisation ultérieure comme immunogène dans la production d'anticorps pour des applications de test sont également décrits. Un test ELISA servant à mesurer les antigènes dégagés présents dans les échantillons d'un patient ainsi qu'un test enzymatique destiné à servir de mesure d'activité dans des spécimens sont également décrits.
Patent CA-2202184-A1 (CA)
Title: Method for making alsimgcu alloy products having enhanced intercrystalline corrosion resistance
Inventor: WARNER TIMOTHY
IPC: C22F1/057
Filed: 1995-10-24
Abstract: A method for making high-strength rolled or extruded AlSiMgCu aluminium alloy products desensitised to intercrystalline corrosion, comprising a step of casting a plate or billet having the following composition: Si 0.7-1.3 %, Mg 0.6-1.1 %, Cu 0.5-1.1 %, Mn 0.3-0.8 %, Zr < 0.20 %, Fe < 0.30 %, Zn < 1 %, Ag < 1 %, Cr < 0.25 %, others < 0.05 % each and < 0.15 % in all, with the balance being aluminium and Mg/Si < 1; a homogenising step at 470-570  DEG C; a hot and optionally cold working step; solution treatment at 540-570  DEG C; a hardening step; and a tempering step including at least one temperature plateau at 120-250  DEG C, preferably 165-220  DEG C, the overall process length measured in equivalent time at 175  DEG C being 30-300 hours. A product having the composition given above and a conductivity, when desensitised to intercrystalline corrosion, at least 0.5 MS/m higher than in state T6, is also disclosed. Such products are particularly suitably for making structural members for aircraft fuselages or rail or road vehicles.
Patent CA-2212005-A1 (CA)
Title: Temple for eyewear
Inventor: RAUB JEFFREY K
IPC: G02C5/22
Filed: 1996-01-30
Abstract: Temples for eyewear include a first portion for contacting the head of the wearer and a second portion for connecting the first temple portion to the eyewear front. The first temple portion is movable to accommodate a wide variety of head shapes or sizes and provide a more secure fit.
Patent CA-2216765-A1 (CA)
Inventor: LANGE BARRY CLIFFORD
IPC: A01N47/14
Filed: 1997-09-29
Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a halopropargyl quaternary ammonium compound, halopropargyl benzoxazolone compound, or halopropargylhydantoin compound. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.
Patent CA-2219542-A1 (CA)
Title: Regenerative heater of diesel engine particulate trap and diesel engine particulate trap using the same heater
Inventor: OOKA TUTOMU
IPC: B01D46/42
Filed: 1997-10-21
Abstract: Thin plate-like electric heaters are disposed among multi-layer cylindrical filters for capturing particulates in positions without contacting with the filters.  As the means for more reducing the power supply to the heater as the position of the heater is closer to the central cylinder of the multi-layer filters, the thicknesses of the thin plate-like electric heaters or the geometrical patterns of the electric conduction paths are changed to thereby set the resistance values of the heaters in advance in order to reduce the temperature of the central-side cylinder which is apt to be high to thereby realize the balance with the temperature of the-outer-circumferential cylinder, or the electric conduction quantity to the heaters is selectively more reduced as the position of the heater is closer to the central cylinder to realize the balance of temperature distribution with the filter on the outer-circumferential side filter.
Patent CA-2220301-A1 (CA)
Title: Osmotic device with delayed activation of drug delivery and complete drug release
Inventor: DONG LIANG C
IPC: A61K38/27
Filed: 1996-05-29
Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the expansion of an expansion agent in the active agent delivery chamber.
Patent CA-2223436-A1 (CA)
Inventor: AUER HENRY
IPC: A61K47/30
Filed: 1996-06-03
Abstract: L'invention concerne une composition, ainsi que des procédés de préparation et d'utilisation de ladite composition, pour la libération soutenue d'une hormone de croissance humaine (hGH) biologiquement active stabilisée. La composition à libération soutenue selon l'invention comprend une matrice polymère d'un polymère biocompatible et de particules de hGH biologiquement active stabilisée, dans laquelle lesdites particules sont dispersées à l'intérieur du polymère biocompatible. Conformément à l'invention, le procédé de production d'une composition pour la libération soutenue de hGH biologiquement active consiste à dissoudre un polymère biocompatible dans un solvant polymère, de manière à former une solution polymère, à disperser dans cette solution polymère les particules de hGH biologiquement active stabilisée par des cations métalliques, puis à solidifier le polymère de manière à former une matrice polymère contenant une dispersion desdites particules hGH. Le procédé d'utilisation de ladite composition est un procédé permettant d'obtenir une concentration sanguine thérapeutiquement efficace de hGH biologiquement active non agglomérée chez un sujet pendant une période prolongée. Selon ce procédé, on administre à un sujet une dose efficace de ladite composition à libération soutenue. Le procédé d'utilisation de ladite composition à libération soutenue consiste à fournir à un sujet, pendant une période prolongée, une concentration sanguine thérapeutiquement efficace de l'hormone de croissance biologiquement active non agglomérée, en administrant à ce sujet, une dose de ladite composition à libération soutenue.
Patent CA-2223760-A1 (CA)
Title: Method for determining alcohol consumption rates
Inventor: HARASYMIW JAMES W
IPC: G01N33/98
Filed: 1996-06-07
Abstract: A method for assessing or determining alcohol consumption rates including using a blood specimen from a human subject to develop an individual blood constituent panel; comparing the individual panel with a reference blood constituent panel to provide categories corresponding to rates of alcohol consumption; and identifying the category of consumption rate. The methods of the invention can be varied through modification of one of several statistical models used therewith to preferentially weigh the analysis and identify one consumption category over another. Multi-variate and similar such statistical techniques correlate comparisons of individual/subject blood and reference panel constituents with recognized consumption rates.
Patent CA-2224062-A1 (CA)
Title: Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
Inventor: PHILLIPS DOUGLAS
IPC: C07D277/20
Filed: 1995-06-06
Abstract: Compounds of Formula (1) wherein R6 is carboxy, (C1-C8)alkoxycarbonyl, benzyloxycarbonyl, C(O)NR8R9 or C(O)R12 as glucogen phosphorylase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat diabetes, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis and myocardial ischemia in mammals.
Patent CA-2224944-A1 (CA)
Inventor: HAGERTY ANDREW J
IPC: A61F13/32
Filed: 1996-06-21
Abstract: The present invention relates to an insertion device formed of a tubular element capable of substantially containing an insertable element. The tubular element has an insertion end and a gripper end. The gripper end has a plurality of finger-accepting apertures. These apertures are dimensioned to accept a portion of a user's finger. This device is particularly useful in a tampon applicator tube which has a high-gloss outer surface.
Patent CA-2225061-A1 (CA)
Inventor: DE VRIES ROBERT GEORG
IPC: A01N35/06
Filed: 1998-01-27
Abstract: In order to reduce the amount of synthetic fungicides used in the storage of potatoes, a method of repelling fungi in potatoes as effectively as possible has been looked for. What has also been looked for is an agent that is effective both for repelling fungi and for inhibiting sprouting in the storage of potatoes. It has been found that a combination of carvone and one or more fungicides leads to a synergistic effect both for repelling fungi and for inhibiting sprouting.
Patent CA-2225815-A1 (CA)
Title: High-temperature fuel cell system and a method for its operation
Inventor: LEHMEIER JUERGEN
IPC: H01M8/04014
Filed: 1996-06-25
Abstract: The invention concerns a high-temperature fuel cell installation (2) having at least one high-temperature fuel cell block (4) heated by at least one electric heating element (12, 14). The heating element (12, 14) is disposed outside the high-temperature fuel cell block (4). As a result of this measure, the fuel cells are neither fouled nor damaged.
Patent CA-2226426-A1 (CA)
Title: Process for evaluating the sensitizing and/or irritant and/or allergenic nature of a product
Inventor: SCHMIDT RAINER
IPC: G01N33/50
Filed: 1998-02-10
Abstract: Evaluation of the potential of a product to cause sensitisation, allergy and/or irritation comprises simultaneous cultivation of keratinocytes and precursors of Langerhans cells and contacting the product with the culture long enough for a marker to change sufficiently to be measured.
Patent CA-2227731-A1 (CA)
Title: Waiting-call selection based on objectives
Inventor: FLOCKHART ANDREW D
IPC: H04M3/60
Filed: 1998-01-22
Abstract: Call-center (FIG. 1) performance is improved by assigning different service-time objectives (222) to different types of calls or to call queues (21) for different types of calls, and then selecting (212), for an agent (25) who has just become available (200) to handle a call, a waiting call that is farthest along in exceeding its assigned service-time objective. The objectives represent limits on the amount of time that calls should spend waiting for agents before being handled. For example, a video call may need to be serviced within tens of seconds of its arrival, and a voice-only call may need to be serviced within minutes, while e-mail may need a response within hours of its arrival. Relative distance of calls from their assigned service-time objectives is preferably determined by determining (206) the calls'present or anticipated wait times and computing (210) weighted percentages of the assigned service-time objectives that are represented by the present or anticipated wait times. The call with the highest weighted percentage is then selected (212) and assigned (214) to the available agent for handling. The process is repeated each time that any agent becomes available.
Patent CA-2233377-A1 (CA)
Title: Nk-1 receptor antagonists for the treatment of delayed emesis
Inventor: TSUCHIYA MEGUMI
IPC: A61K33/243
Filed: 1998-03-26
Abstract: Disclosed is a pharmaceutical composition comprising an NK-1 receptor antagonist (e.g., substance P receptor antagonist) for treatment delayed emesis.  More specifically, the composition comprises a therapeutically effective amount of: (2S,3S)-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpiperidine; (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine; or (2S,3S)-N-(5-isopropyl-2-methoxyphenyl)methyl-2-diphenyl-methyl-1-azabicyclo-[2.2.2]octan-3-amine; or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier or diluent.
Patent CA-2234255-A1 (CA)
Title: Cephalosporin antibiotics
Inventor: GLINKA TOMASZ
IPC: A61P31/04
Filed: 1996-10-11
Abstract: The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.