baber/WOPTO huggingface dataset:
Patent CA-2463821-A1 (CA)
Title: Amide derivatives as glycogen synthase kinase 3-beta inhibitors
Inventor: LEWI PAULUS JOANNES
IPC: C07D403/14
Filed: 2002-10-29
Abstract: This invention concerns a compound of formula (I' ),a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-member ed heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1- 6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2- 6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1- 6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amin o; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21-C1- 6alkyl; R21-O-; R21-S-; R21-C(=O)-; R21-S(=O)p-; R7-S(=O)p-; R7-S(=O)p-NH-; R21-S(=O)p-NH-; R7-C(=O)-; -NHC(=O)H;-C(=O)NHNH2; R7-C(=O)-NH-; R21-C(=O)-NH -; -C(=NH)R7; -C(=NH)R21 ; R4a or R4b each independently represent hydrogen, R8 , - Y1-NR9-Y2-NR10R11, -Y1-NR9-Y1-R8, -Y1-NR9R10; provided that -X-R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.
Patent CA-2467173-A1 (CA)
Inventor: JOSEPH LANCE
IPC: B65H75/40
Filed: 2004-05-13
Abstract: A cable reel consisting of a housing which has at least one plug socket mounted within the housing, the socket is provided with apertures configured to receive the pins or a plug, the reel also includes a store of electric cable and a strap adapted to locate the cable reel adjacent to a user's body,
Patent CA-2474192-A1 (CA)
Inventor: WALKER ANN LOUISE
IPC: A61P9/10
Filed: 2003-02-10
Abstract: L'invention concerne des composés de la formule (I), qui sont des inhibiteurs de la kinase p38 utiles dans le traitement de pathologies ou de maladies induites par l'action de la kinase p38 ou par des cytokines produites par l'action de la kinase p38.
Patent CA-2475493-A1 (CA)
Title: Procede d'elaboration de preparations a base de semicarbazones et/ou de thiosemicarbazones a l'aide de cyclodextrines et de leurs derives, et produits ainsi obtenus
Inventor: TEIXEIRA LETICIA REGINA DE SOU
IPC: A61K31/175
Filed: 2003-02-05
Abstract: La présente invention concerne, d'une part, un procédé d'élaboration de préparations à base de semicarbazones et/ou de thiosemicarbazones à l'aide de cyclodextrines et de leurs dérivés et, d'autre part, des produits obtenus selon ce procédé. Le procédé décrit dans cette invention consiste à obtenir des composés d'inclusion de semicarbazones et/ou de thiosemicarbazones à l'aide de cyclodextrines et de leurs dérivés, préalablement testés dans des modèles d'épilepsie expérimentale et permettant de réduire la dose d'anticonvulsivant de 100mg/kg à 25mg/kg. Ce procédé permet d'améliorer la biodisponibilité des composés dans les systèmes biologiques. Les résultats obtenus sur des modèles animaux permettent de considérer que les semicarbazones et/ou les thiosemicarbazones contenus dans les cyclodextrines et dans leurs dérivés sont des nouveaux anticonvulsivants potentiels. Le procédé décrit dans cette invention permet également d'améliorer l'efficacité des semicarbazones et/ou des thiosemicarbazones contenus dans les cyclodextrines et dans leurs dérivés par rapport à des composants libres. En outre, les semicarbazones et les thiosemicarbazones ont un effet analgésique lorsqu'ils sont inclus dans les cyclodextrines.
Patent CA-2476560-A1 (CA)
Title: Water driven roller massager
Inventor: ELNAR JOSEPH G
IPC: A61H15/00
Filed: 2004-08-04
Abstract: A water driven massager mounted in an opening in the wall of a spa. The massager includes a main housing secured to the wall opening and extending outwardly from the wall (i.e., away from a spa user). A gear housing is mounted in the main housing and contains a drive mechanism rotationally connecting between a turbine and a rotating massager. The drive mechanism includes two in-series planetary gear sets for reducing Revolutions Per Minute (RPM) of the rotating massager. The rotating massager includes a plurality of rotating balls held in a ball plate residing proximal to the plane of a spa surface of the wall (i.e., the spa wall surface facing the user), and is covered by a boot providing a massager surface. The ball plate rotates at between 50 and 80 RPM thereby providing a rotating massage on the surface of the boot. The gear pausing is easily removed through the wall opening for service and maintenance.
Patent CA-2477125-A1 (CA)
Inventor: WHITTAMORE PAUL ROBERT OWEN
IPC: A61K31/496
Filed: 2003-03-04
Abstract: Heterocyclic amides of formula (1) wherein: Z is CH or nitrogen; R4 and R5 together are either -S-C(R6)=C(R7)- or -C(R7)=C(R6)-S- ; R6 and R7 are selected from for example hydrogen, halo, C1-4alkyl, and C1-4alkanoyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; r is 1 or 2; Y is -NR2R3 or -OR3; R2 a nd R3 are selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C 1- 4alkyl (optionally substituted by 1 or 2 R8 groups); R4 is selected from for example hydrogen, halo, nitro, cyano, hydroxy, C1-4alkyl, and C1-4alkanoyl; R8 is selected from for example hydroxy, -COCOOR9, -C(O)N(R9)(R10), -NHC(O)R9 , (R9)(R10)N- and -COOR9 ; R9 and R10 are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13 ); R13 is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy; or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibito ry activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
Patent CA-2479450-A1 (CA)
Title: Ca, mg and ni containing alloys, method for preparing the same and use thereof for gas phase hydrogen storage
Inventor: LIANG GUOXIAN
IPC: H01M4/38
Filed: 2004-08-25
Abstract: Disclosed are new Ca, Mg and Ni-containing alloys of the general formula: (Cac Mgd Me)b(Ni1-zTz)a where:   M is at least one metal selected from the group consisting of Y, Ce, La, Pr, Nd, Th, Nd, Ti, V, Zr, Ta, Hf, Sr, Ba and Misch metals;    T is at least one element selected from the group consisting of Al, Zn, Cu, Fe, Co, Mn, Cr, Mo, W, Si, Ga, Ge, In, Sn, Ag, C and B; a is an integer equal to 2 or 5; z is a number ranging from 0 to 0.5; and when a is equal to 2, then 0.9<=b<=1.1; and when a is equal to 5, then either 1.75<=b<=2.25 or 0.75<=b<=1.31.      These alloys which are of the AB2, A2B5 or AB5 types, may be single phase or multiphase and are useful for reversibly absorbing hydrogen from a gas phase. Also disclosed is a method for preparing the above alloys.
Patent CA-2479735-A1 (CA)
Title: Fast dissolving dosage forms having reduced friability
Inventor: PRUSS KARL
IPC: A61K47/30
Filed: 2003-03-20
Abstract: Disclosed is a rapidly disintegrating or dissolving (fast melt) solid dosage form of at least one active agent and at least one pharmaceutically acceptable water-disintegrable or water-soluble excipient, wherein the dosage form has two opposed double-convex surfaces. The dosage form of the invention has the advantage of exhibiting low friability with a very low disintegration time.
Patent CA-2484017-A1 (CA)
Title: Indol-2-ones as selective inhibitors of cyclooxygenase-2
Inventor: CROSSON RHONDA MARIE
IPC: A61K31/497
Filed: 2003-04-10
Abstract: The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula (I) pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the invention are particularly useful in the treatment or alleviation of inflammation and inflammation associated disorders, such as, for example, rheumatoid arthritis and osteoarthritis, and in the relief of pain, such as, for example, pain associated with surgery or trauma, in mammals. preferably felines and canines.
Patent CA-2485055-A1 (CA)
Title: In situ dilution of external controls for use in microarrays
Inventor: BOUCHER SHERRI
IPC: C12Q1/68
Filed: 2004-10-18
Abstract: An array in which an external control feature for normalization has been designed and tested for its ability to mimic the range of observed expression levels for a test set of oligos. The external control probes span a series of concentrations. They are spatially randomized across a grid of an array. The series of concentrations is duplicated in a given grid. The individual grid layout and number of control and external normalization features per grid have been designed to cope with sources of both systematic error and spatial variation.
Patent CA-2486794-A1 (CA)
Title: Pharmaceutical composition for controlled drug delivery system
Inventor: JOSHI MILIND DATTATRAYA
IPC: A61P1/04
Filed: 2002-06-14
Abstract: The present invention describes a novel controlled release multilayer composition that is capable of delivering a first active agent from one laye r immediately followed by continuous controlled delivery of second active agen t from matrix forming layer while the dosage form floats and is retained in th e fluid of the environment. The floating bilayer system comprises of immediate release layer containing one active agent and a disintegrating agent whereas second floating matrix forming layer comprises a gas generating component, a gelling agent, and a second active agent. The present invention relates more particularly to a controlled release fluoroquinolone compositions, which maintain a therapeutically effective blood concentration of fluoroquinolone for duration with once a day administration.
Patent CA-2487178-A1 (CA)
Title: Lobed drive for hi-lite fastener
Inventor: SCHULTZ DENNIS
IPC: F16B23/00
Filed: 2003-05-19
Abstract: A drive socket (20) for a male threaded fastener (26) includes a plurality of rounded lobes (22) of equal radius which are located equidistant from the center (24) of the fastener and an equal distance from each other. The drive socket also includes flat surfaces (28) located opposite the lobes and equidistant from the center of the fastener. Another embodiment of a drive socket includes a first set of lobes (52) and a second set of lobes (54), each lobe being of equal radius and equidistant from the center of the fastener.  The lobes of the first set are equidistant apart and the lobes of the second set are also equidistant apart and equidistant apart from the adjacent lobes of the first set on either side of the lobe of the second set. Each of the lobes of the first set includes a flat surface (60) which is adjacent and tangential to the radius portion of the lobe.
Patent CA-2488761-A1 (CA)
Title: 2-benzofuryl or benzothiophenyl-quinuclidinyl amides as nicotinic acetylcholine receptor inhibitors
Inventor: VAN KAMPEN MARJA
IPC: A61P25/00
Filed: 2003-06-02
Abstract: The invention relates to the novel 2-heteroaryl carboxamides according to formula (I), wherein R1 represents 1-aza-bicyclo [2.2.2]oct-3-yl, which is optionally replaced via the nitrogen atom by a group selected from the famil y C1-C4 alkyl, benzyl and oxy, A represents oxygen or sulfur, the ring B represents benzo or pyrido that are optionally replaced by the groups from t he family of halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkyl and C1-C6 alkoxy, E represents C=C, aryl and heteroaryl, wherein aryl and heteroaryl may be replaced by groups from the family of halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkox y and C1-C6 alkyl, and to the solvents, salts or solvents of salts of said compounds. The invention also relates to the use of said compounds in the production of drugs for the treatment and/or the prophylaxis of diseases and for improving perception, power of concentration, learning power and/or retentiveness of memory.
Patent CA-2489956-A1 (CA)
Title: Generation of elevated pressure gas mixtures by adsorption and stripping
Inventor: PENG XIANG-DONG
IPC: C01B32/50
Filed: 2004-12-13
Abstract: Method of making a product gas mixture comprising providing a first gas mixture, contacting the first gas mixture with a lean absorber liquid at a first pressure and absorbing a portion of the first gas mixture in the lean absorber liquid to provide a rich absorber liquid and a non-absorbed residual gas, pressurizing the rich absorber liquid provide a pressurized rich absorber liquid, stripping the pressurized rich absorber liquid with a stripping gas at a second pressure greater than the first pressure to provide a pressurized lean absorber liquid and the product gas mixture, and reducing the pressure of the pressurized lean absorber liquid to provide the lean absorber liquid at the first pressure.
Patent CA-2490508-A1 (CA)
Title: Cleaning rolls, cylinders and printing forms by jet of frozen particles
Inventor: GOETTLING JOSEF
IPC: B41F35/06
Filed: 2004-12-17
Abstract: An apparatus for cleaning and/or removing images from surfaces, in particular from roll or cylinder surfaces or printing forms is provided. The cleaning apparatus includes one or more blasting nozzles for discharging water in the form of solid particulate matter able to change to a liquid or gas at ambient temperature and pressure without harming the surface to be cleaned onto the surfaces to be cleaned. The discharged solid particulate matter effectively removes dirt particles or ink-carrying polymers. The dislodged material and the waste ice, which may have changed into water droplets (6), is removed from the surface and taken away.
Patent CA-2490620-A1 (CA)
Inventor: VAN DER WIELEN PETRUS CAROLINA
IPC: H04B3/56
Filed: 2003-06-23
Abstract: The invention relates to a method for inputting an information signal into a power cable which is connected to a voltage supply and which comprises at least one or more conductors, a dielectric provided around the conductors an d a conductive earth sheath arranged wholly or partially around the dielectric , the method comprising of inputting a pulse-like information signal at a firs t position via the earth sheath in order to produce a corresponding pulse-like information signal which is propagated to a second position in the dielectri c of the power cable.
Patent CA-2492063-A1 (CA)
Title: Electric shaver with vibrating head
Inventor: SHALEV PINCHAS
IPC: A45D26/00
Filed: 2003-03-13
Abstract: A hair cutting apparatus comprising: an elongate element (260) heated to a temperature capable of cutting hair; a vibrating structure (200), on which said elongate element (260) is mounted; and a housing (106) in which the vibrating structure (200) is mounted.
Patent CA-2494133-A1 (CA)
Inventor: LIN SHUJIE
IPC: C03C25/6208
Filed: 2003-07-31
Abstract: The present invention is directed to the creation of zones of permanently altered refractive index characteristics in glass waveguiding devices, including optical fibers and optical waveguides pre-existed in a glass substrate. Such zones are created in glass using a very high intensity laser beam which is produced by focussing the light output from an ultrafast pulsed laser at a predetermined target region in the glass. The preferred laser is a Ti:Sapphire amplified, frequency-doubled Erbium-doped fiber laser system, providing light pulses of approximately 100 femtosecond duration, each with an energy of between about 1 nanojoule and 1 millijoule, and preferably at a pulse repetition rate of between 500 Hz and 1 GHz. The repetition rate is chosen to deliver pulses faster than the thermal diffusion time over the dimensions of the volume element being modified
Patent CA-2494342-A1 (CA)
Title: Compositions retard injectables et utilisation de ces compositions
Inventor: CHEN GUOHUA
IPC: A61K9/00
Filed: 2002-11-14
Abstract: L'invention concerne des compositions retard injectables comprenant un polymère biocompatible bio-érodable, un solvant présentant une miscibilité avec l'eau inférieure ou égale à 7 % pds à 25 ·C, à une dose suffisante pour plastifier le polymère et former un gel avec ce dernier, un agent thixotropique et un agent traitant. Le solvant comprend un alcool aromatique, un ester d'un acide aromatique, un cétone aromatique ou des mélanges de ceux-ci. Ces compositions présentent un comportement de rhéo-fluidification sensiblement amélioré et une force d'injection réduite, ce qui permet de les implanter facilement par injection sous la surface corporelle du patient.
Patent CA-2498972-A1 (CA)
Inventor: BALLIELLO PAOLO
IPC: C09B67/00
Filed: 2003-11-24
Abstract: The invention relates to a composition comprising from 92 to 97 % by weight pigment and from 3 to 8 % by weight binder, in each case based on the composition, wherein the binder is a mixture comprising: from 5 to 60 % by weight, based on the binder, of modified cellulose wherein, on average, per glucose unit, from 0.5 to 1.4 hydroxyl hydrogen atoms are replaced by R1, fr om 0.25 to 0.6 hydroxyl hydrogen atoms are replaced by R2, or from 0.5 to 1.4 hydroxyl hydrogen atoms are replaced by R1, and from 0 to 0.6 hydroxyl hydrogen atoms are replaced by R2 ; and from 40 to 95 % by weight, based on the binder, of a compound of formula (I) wherein Q is a hydrocarbon radical containing from 8 to 24 carbon atoms, unsubstituted or mono- to tri- substituted by hydroxy or OR1, each R1, independently of any other R1, is C1 ,- C4alkyl or C1-C4alkylcarbonyl, each R2, independently of any other R2, is an organic group different from R1 and containing from 2 to 10 carbon, from 0 t o 4 oxygen and from 0 to 2 nitrogen atoms, and R3 and R4 are each independentl y of the other hydrogen, R1, R2, C5-C8alkyl, C5-C8alkylcarbonyl, C5-C8alkenyl, C5-C8alkenylcarbonyl, C5-C8cycloalkyl, C5-C8cycloalkylcarbonyl, C5- C8cycloalkenyl, C5-C8cycloalkenylcarbonyl, phenyl, benzoyl, tolyl, methylbenzoyl, benzyl, phenylacetyl, phenethylor styryl. The compositions according to the invention are dust-free and produce outstanding colorations . The use thereof as colorants for, especially, polyolefins and the preparatio n thereof, especially by aqueous dispersal and spray-drying, are also claimed.
Patent CA-2499913-A1 (CA)
Title: Capacity altering device, holder and methods of sample processing
Inventor: CHANG JIM
IPC: B01L9/00
Filed: 2003-10-08
Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of he devices and/or minimize handling of the external processing regions.  Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.
Patent CA-2500367-A1 (CA)
Inventor: SAWA YOSHIKI
IPC: A61P9/00
Filed: 2002-12-27
Abstract: It is intended to provide a method of inhibiting neointimal thickening in a graft by using a decoy against NF.kappa.B and thus regulating (inhibiting) t he transcription activated by NF.kappa.B. Also, an agent containing a decoy of NF.kappa.B which protects a vascular graft against intimal thickening.</SDOA B>
Patent CA-2501889-A1 (CA)
Title: Utilisation de beta-glucanes contre des armes de guerre biologiques et des agents pathogenes notamment l'anthrax
Inventor: OSTROFF GARY R
IPC: A61K45/06
Filed: 2003-10-09
Abstract: La présente invention concerne un moyen destiné à protéger globalement les militaires ainsi que les civils contre des lésions occasionnées par des armes de guerre biologiques, en particulier des agents infectieux tels que l'anthrax. Les Bêta (1,3)-glucanes, notamment les particules de glucanes entiers, le PGG-Glucane, et du glucane microparticulaire fournissent une augmentation immune générale, accroissant ainsi la capacité du corps à se défendre contre une large gamme de menaces biologiques. Les Bêta (1,3)-glucanes se sont illustrés par une augmentation de la résistance à l'infection par anthrax et d'autres organismes infectieux lorsqu'ils sont administrés avant et après infection. Le mécanisme anti-infectieux du .beta.(1,3)-glucane s'avère induire une stimulation du système immun inné par une libération accrue de cytokine et l'activation du récepteur CR3. Le Bêta (1,3)-glucane est pharmaceutiquement stable, relativement compact et peut aussi être utilisé sans effet secondaire notable. Le Bêta (1,3)-glucane peut également augmenter l'efficacité d'autres contre-mesures médicales telles que les antibiotiques, les vaccins et les anticorps immuns.
Patent CA-2502776-A1 (CA)
Inventor: BOATRIGHT JEFF
IPC: B21J9/02
Filed: 2005-03-31
Abstract: The present invention is a long reach press comprising a low force actuator for operably urging first tooling into a working position. It further includes an opposed high force actuator for operably urging second tooling into engagement with the first tooling. The low force actuator includes a positive stop actuator including a slide block stop for operatively supporting and restraining movement of the first tooling when engaged with the second tooling. The slide block is moveable between a stop extended position and a stop retracted position.
Patent CA-2504711-A1 (CA)
Title: Hcv vaccine compositions comprising e1 and ns3 peptides
Inventor: MAERTENS GEERT
IPC: C07K14/18
Filed: 2003-11-06
Abstract: The invention relates to immunogenic and vaccine compositions useful in prophylactic and therapeutic treatment of HCV infection. More specifically, said compositions comprise a HCV envelope peptide E1 and a HCV non-structural peptide NS3.
Patent CA-2505037-A1 (CA)
Inventor: SCOTT MICHEAL ROBERT
IPC: B27B17/00
Filed: 2005-04-20
Abstract: Disclosed is a mechanical non expanding light beam device. This tool used with chainsaws allows for accurate cutting of equal lengths of wood material. Fixed alignment of the securing clamp body parallel with the end of the chainsaw bar allows the light beam to be manually rotated through a fixed plane. Upon intersection of the beam with the end of the material, the cut is made achieving accurately uniform pieces of material. The device is secured to the chainsaw by an integrated mounting pad and is removable.      The non expanding light beam is manually activated by thumb pressure.
Patent CA-2507882-A1 (CA)
Inventor: CHAN ANDREW CHEE-YUEN
IPC: C12N5/06
Filed: 2003-12-11
Abstract: La présente invention concerne généralement des animaux transgéniques non humains exprimant des marqueurs cellulaires humains, dont CD20. Elle concerne également des méthodes d'utilisation desdits animaux pour identifier des agents pouvant appauvrir efficacement des cellules porteuses du CD20 humain. Les animaux transgéniques de l'invention peuvent également être utilisés pour tester la sécurité et l'efficacité de traitement anti-CD20.
Patent CA-2509483-A1 (CA)
Title: Implementation of concurrent programs in object-oriented languages
Inventor: GUSTAFSSON NIKLAS
IPC: G06F9/44
Filed: 2005-06-08
Abstract: The present invention adds support for concurrency to a mainstream object-oriented language. Language extensions are provided that can enable programs to be developed that can either be run in one address space, distributed across several process on a single computer, or distributed across a local-area or wide-area network, without recoding the program. Central to this aspect is the notion of a service, which can execute its own algorithmic (logical) thread. Services do not share memory or synchronize using explicit synchronization primitives. Rather, both data sharing and synchronization is accomplished via message-passing, e.g., a set of explicitly declared messages are sent between services. Messages can contain data that is shared, and the pattern of message exchange provide the necessary synchronization.