Patent SG-11201804710T-A (SG)
Title: Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof
Inventor: INGBER DONALD
IPC: C12M3/00
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DID Ell 1111111111111111111111111111111111 RID IIII (10) International Publication Number WO 2017/096192 Al WIPO I PCT (43) International Publication Date 8 June 2017 (08.06.2017) Massachusetts 02446 (US). HANEY, Suzzette; c/o Presid- ent and Fellows of Harvard College, 17 Quincy Street, Cambridge, Massachusetts 02138 (US). PATEL, Payal; 34 Weir Rd., Waltham, Massachusetts 02451 (US). HER- LAND, Anna; Hemmansgatan 76, 583 36 Linkoping (SE). RESNIKOFF, Joshua; 9 Olive Square, Somerville, Mas- sachusetts 02143 (US). (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, 70 W. Madison St., Suite 3500, Chicago, Illinois 60602- 4224 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (51) International Patent Classification: C12M 3/00 (2006.01) GO1N 33/50 (2006.01) C12N 5/22 (2006.01) BOIL 99/00 (2010.01) GO1N 33/483 (2006.01) B81B 7/00 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/US2016/064661 2 December 2016 (02.12.2016) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/263,378 4 December 2015 (04.12.2015) US (71) Applicant: PRESIDENT AND FELLOWS OF HAR- VARD COLLEGE [US/US]; 17 Quincy Street, Cam- bridge, Massachusetts 02138 (US). (72) Inventors: INGBER, Donald, E.; 162 W. Canton St., Bo- ston, Massachusetts 02118 (US). HAMILTON, Ger- aldine; 20 McTeman St., Cambridge, Massachusetts 02138 (US). JANG, Kyung-Jin; 193 Aspinwall Ave., Brookline, [Continued on next page] (54) Title: DEVICES FOR SIMULATING A FUNCTION OF A LIVER TISSUE AND METHODS OF USE AND MANUFAC- TURING THEREOF FIG. 29B 214 210 211 217 2 204 17 (57) : Provided herein relates to devices for simu- lating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tis- sue. Endothelial cell culture media for long-teiin culture of endothelial cells are also described herein. 225 W O 20 17 /096 19 2 Al WO 2017/096192 Al IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii))