baber/WOPTO huggingface dataset:
Patent CA-2343963-A1 (CA)
Inventor: MIELE LUCIO
IPC: A61K39/395
Filed: 1999-10-01
Abstract: L'invention concerne des méthodes et compositions destinées à induire une différenciation et une apoptose dans des cellules surexprimant des protéines de Notch. Une fonction de détermination du sort d'une cellule est spécifiquement interrompue au moment où la cellule subit une différenciation, ce qui provoque l'apoptose de la cellule. L'invention concerne des thérapies de tumeurs surexprimant une protéine de Notch (telles que Notch-1) par induction d'une différenciation des cellules dans la tumeur grâce à un agent d'induction de différenciation tel que HMBA, en combinaison avec un agent interrompant la fonction de la protéine de Notch. Lorsque la différenciation a été lancée et que la cellule est susceptible de perturber l'effet anti-apoptose de Notch, la fonction de la protéine de Notch est interrompue. L'interruption de la fonction de Notch peut être réalisée, par exemple, par un agent induisant une différenciation, tel que HMBA, combiné à des anticorps se liant spécifiquement à Notch et l'inactivant, par exemple un anticorps monoclonal qui reconnaît les séquences répétées 11 et 12 de type EGF de Notch-1, telles que les anticorps monoclonaux A6, C11 ou F3. L'interruption de la fonction de Notch peut également être réalisée, par exemple, par l'expression d'oligonucléotides antisens perturbant spécifiquement l'expression de la protéine de Notch sur la cellule, seuls ou en combinaison avec des agents antinéoplasiques.
Patent CA-2344493-A1 (CA)
Title: Method and device for controlling animal feeding when milking dairy animals
Inventor: NORBERG HENRIK
IPC: A01K5/02
Filed: 1999-09-03
Abstract: The present invention relates to a device and method for the milking of dairy animals, comprising: individual identifying means attachable to each individual dairy animal; simple feeding station, provided with food dispensing means for dispensing fodder and sensing means for sensing said individual identifying means; combined feeding and milking stations, provided with food dispensing means for dispensing fodder, milking means for milking animals and sensing means for sensing said individual identifying means; and control means for controlling the simple feeding stations and combined feeding and milking stations, wherein the control means comprises: determining means for determining a time for the next milking of said individual animal; and output means for commanding said simple feeding stations to stop dispensing food to said individual animal if the actual time is after said time for the next milking of said animal.
Patent CA-2346289-A1 (CA)
Title: Pyrazolo-triazine derivatives as ligands for gaba receptors
Inventor: MOORE KEVIN WILLIAM
IPC: A61K31/53
Filed: 1999-10-13
Abstract: A class of substituted pyrazolo[1,5-d][1,2,4]triazine derivatives, possessin g an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at th e 7-position and a substituted alkoxy moiety at the 2-position, are selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
Patent CA-2348428-A1 (CA)
Title: Method and apparatus for disabling uninsured motor vehicles
Inventor: VOLL LELAND
IPC: B60R25/04
Filed: 2001-06-05
Abstract: A method and apparatus for disabling uninsured motor vehicles. A first step involves providing a timer. A second step involves setting the timer to monitor the time duration until insurance on a motor vehicle expires. A third step involves connecting the timer to an electronic control system of a motor vehicle in such a manner that the electronic control system disables the motor vehicle if any one of the following events occurs, namely: the timer reports that insurance has expired, the timer is removed, the timer is tampered with by unauthorized persons.
Patent CA-2348834-A1 (CA)
Inventor: KLEIMAN JACOB I
IPC: B24B39/00
Filed: 2001-05-29
Abstract: A device for ultrasonic peening of metals is intended for strengthening and relaxation treatment of metal surfaces with an ultrasonic oscillation and includes an ultrasonic generator (1) having the optimized power of from 0.2 to 0.5 kW, a piezoelectric transducer with an ultrasonic velocity transformer (6) and a set of readily replaceable heads with striking tools (pins). Various sizes and arrangements of the tools allow for ultrasonic peening of parts of complicated configuration fast and efficiently. In the device, drop-wise cooling and lubrication of striking tools, as well as of treatment area are provided.
Patent CA-2356093-A1 (CA)
Inventor: LEE IVAN S
IPC: C08J7/046
Filed: 1999-12-16
Abstract: Rubber articles are coated with a powder-free copolymer coating to provide improved mold release characteristics, improved donning characteristics, and  improved tactile feel. The copolymer is formed by the polymerization of a lo w surface energy monomer, an alkyl acrylate, a hard monomer and urethane oligomer. The copolymers are preferably formed by a sequential polymerizatio n process.
Patent CA-2356150-A1 (CA)
Inventor: SCHILLING DONALD L
IPC: H04Q7/32
Filed: 1993-10-06
Abstract: A wireless debit card communication system comprises a radio unit, a base station and an end station. The radio unit comprises a card reader for reading information from a card and a transceiver for transmitting a first signal including the red telephone number to a base station and for receiving calls directed to the red telephone number, whereby the first signal enables the wireless communication system to redirect calls for the red telephone number to the radio unit. Also described is a method for directing to the radio unit calls to a number carried on a card and communicated to a base station.
Patent CA-2356993-A1 (CA)
Title: Improved cooling/heating pad and system
Inventor: CARSON GARY ALLEN
IPC: A61F7/02
Filed: 2000-01-03
Abstract: A medical pad (10) includes a thermal exchange layer capable of absorbing and/or releasing heat to a patient, and an adhesive surface (16A) disposed on a skin-contacting side of the thermal exchange layer of adhering the pad (10) to the skin of the patient. The thermal exchange layer may comprise a fluid containing layer (12) for containing a thermal exchange fluid (14) capable of absorbing thermal energy from, and/or releasing thermal energy to the patient. The pad (10) may also include a conformable, thermally conductive insulating layer (16), and an insulating layer (18). Transverse members (24, 26) or dimples (624) on insulating base member (618) may be provided to define tortuous fluid passageways in fluid containing layer (12). A fluid circulating system (40) includes a pump (42), operating under negative pressure, connected downstream from a fluid outlet (22) and a fluid reservoir (44) connected upstream from a fluid inlet (20).
Patent CA-2361567-A1 (CA)
Inventor: ROBINSON PHILIP S
IPC: C21D9/56
Filed: 2000-02-29
Abstract: The invention concerns heating metal strips or other coilable strand metal object to an elevated temperature, wherein the metal object is passed in a heating section (5) through a furnace chamber (17) that is made at least partly of an insulating and electrically non-conductive material while being heated through transverse flux induction heating (TFIH) by means of transverse flux induction heating elements (15, 16) located outside of said chamber which contains a protective non-oxidising gas or gas mixture. The invention is characterised in that the metal object is a stainless steel object that has been cold rolled to a very high degree of surface reflectively, that the cold rolled stainless steel object is passed through said furnace chamber and is heated in said chamber to a processing temperature between 700 and 1200 ~C, that the cold rolled stainless steel object is maintained at said temperature between 700 and 1200 ~C for long enough for the steel to recrystallize completely, and that the heat treated metal object then is rapidly cooled directly from the processing temperature, in an airtight cooling section (6, 27) through which the non-oxidising gas is passed, to below a temperature of 600 ~C.
Patent CA-2362858-A1 (CA)
Title: Compositions and methods for their preparation from lepidium
Inventor: HE KAN
IPC: A61K31/16
Filed: 2000-03-03
Abstract: The invention relates to compositions that can be isolated fromLepidium plan t material and to methods for their isolation. The compositions are useful for  treating and preventing cancer and sexual dysfunction.
Patent CA-2362873-A1 (CA)
Inventor: AGADJANYAN MICHAEL G
IPC: A61K48/00
Filed: 2000-03-03
Abstract: Methods of inducing an immune response against an immunogen in an individual are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes an immunogen and a nucleotide sequence that encodes a Major Histocompatibility Complex antigen. The nucleotide sequences that encode the immunogen and Major Histocompatibility Complex antigen are expressed when taken up by cells of the individual and an immune response against the immunogen is induced in the individual. Methods of reducing rejection of unmatched donor cells, tissue or organ in an individual undergoing cell, tissue or organ transplantation are disclosed. The methods comprise administering to the individual, one or more nucleic acid molecules that comprise a nucleotide sequence that encodes a death signal or toxin and a nucleotide sequence that encodes a major Histocompatibility Complex antigen that is matched to the donor cells, tissue or organ. The nucleotide sequences that encode the Major Histocompatibility Complex antigen and death signal or toxin are expressed when taken up by cells of the individual. T cell death through interaction with the death signal or toxin results in a reduction of rejection of unmatched donor cells, tissue or organ. Methods of reducing a dominant immune response in an individual and methods of expanding a subpopulation of T cells associated with a specific immune response are also described. Plasmids and compositions comprising plasmids useful for practising the method are described.
Patent CA-2364068-A1 (CA)
Title: System, method, and apparatus for implementation and use of a trading process on a data processing system
Inventor: MIRLAS LEV
IPC: G06Q10/10
Filed: 2001-11-30
Abstract: The invention described herein provides a method, apparatus, and software for implementing a unified trading structure for use in a computerized trading system that implements trading relationship mechanisms for participant roles, including:  selecting a set of characteristics which are common to a plurality of trading relationship mechanisms; the characteristics including: identifying participants for each participant role, terms and conditions that apply to all or selected participants, a description of the relationship, storing the characteristics. Preferably the method may include at least one attachment, which is stored, storing the characteristics, and the at least one attachment. The characteristics of the attachment may include Uniform Resource Information: mime type; and optional content.
Patent CA-2364467-A1 (CA)
Title: Polyester overlamination film with enhanced uv stabilization properties
Inventor: YE YIJUN
IPC: C09J131/04
Filed: 2001-12-04
Abstract: A UVA stabilized polyethylene terephthalate overlamination film having a maximum peak absorption of about 380nm, an approximate absorptive area% of <14% and a Visible Absorbance value of less than about 20%, coated with an adhesive layer to facilitate anchorage of the polyethylene terephthalate film to a secondary print substrate.
Patent CA-2364996-A1 (CA)
Title: Doped precipitated silica
Inventor: LINDNER GOTTLIEB-GEORG
IPC: D21H27/00
Filed: 2001-12-14
Abstract: The invention relates to foreign-atom-doped precipitated silicas having a BET surface area of more than 300 m2/g and a maximum surface concentration of the foreign atoms of 0.05 mmol/m2, to a process for preparing them and to the use of the resulting precipitated silicas in papermaking.
Patent CA-2365260-A1 (CA)
Title: Couplage ameliore pour spectroscopie a cavite "ring-down" basee sur des prismes retroreflecteurs a angle de brewster
Inventor: LEHMANN KEVIN K
IPC: G01J3/10
Filed: 2001-01-18
Abstract: L'invention concerne un résonateur stable destiné à une cellule de spectroscopie à cavité "ring-down" possédant un axe optique. Ce résonateur comprend deux primes rétroréflecteurs à angle de Brewster, chacun possédant plusieurs surfaces à réflexion interne totale, l'une de ces surfaces d'au moins un des prismes étant courbe (obtenue soit par meulage soit par addition, par contact optique ou par collage, d'une lentille plan-convexe à la surface). Les prismes sont disposés alignés selon l'axe optique du résonateur. Un miroir sphérique ou une lentille, écartée de l'incidence normale afin de produire un degré d'astigmatisme recherché, permet un couplage du rayonnement dans le résonateur. Un prisme, ou les deux à la fois, peut être mis en rotation de façon que les rayonnements lumineux entrent et quittent la surface selon un angle presque égal à l'angle de Brewster par rapport à la normale à la surface du prisme. Cette caractéristique permet de maintenir les prismes alignés et au résonateur d'être accordé.
Patent CA-2370450-A1 (CA)
Inventor: RADL ANDREAS
IPC: A61C5/62
Filed: 2002-02-04
Abstract: A syringe-type device for supplying dental material to a dental restoration site includes a syringe body, a syringe connecting body, and an activation component. The syringe body has an outlet and a dental material retaining space for retaining therein a dental material. The syringe connecting body has an upstream opening and a downstream opening and is connectable to the syringe body such that dental material which has exited the syringe body through the outlet thereof flows through the upstream opening into the syringe connecting body and subsequently flows through the downstream opening to the dental restoration site. The activation component is disposable at the outlet of the syringe body and, in a non-actuated condition thereof, at least partially blocks the flow of dental material from the syringe body into the syringe connecting body and, in an actuated condition thereof, permits a relatively greater flow of dental material.
Patent CA-2370605-A1 (CA)
Title: Etrier de serrage a excentrique
Inventor: GASPER THEO
IPC: B25B5/16
Filed: 2000-05-12
Abstract: L'invention concerne un étrier de serrage comprenant un premier support de mâchoire de serrage (2) pouvant être déplacé le long d'une glissière (1) et être fixé dessus par application d'un couple de renversement. Ledit support comprend une première mâchoire de serrage (3) à distance de la glissière (1), du moins par endroits. L'étrier de serrage comprend un second support de mâchoire de serrage (4) situé de manière sensiblement fixe dans la zone d'une extrémité de la glissière et comportant une seconde mâchoire de serrage (5) située à l'opposé de la première (3), cette seconde mâchoire de serrage se déplace sur la première mâchoire de serrage (3) sous l'effet d'une sollicitation du support de mâchoire avec un corps de pression (6) excentrique placé à l'extrémité de la glissière. Selon l'invention, il est prévu pour perfectionner cet étrier de serrage, que le second support de mâchoire (4) puisse pivoter autour d'un pivot (13) par lequel il est fixé sur la glissière (1). Le corps de pression (6) excentrique agit sur un épaulement de pression (7) du second support de mâchoire (4) croisant obliquement la glissière (1).
Patent CA-2372151-A1 (CA)
Inventor: GULDENFELS DIETER
IPC: B65G17/08
Filed: 2002-02-15
Abstract: A belt module having link ends that are beveled inwardly, in the vicinity of the pivot rod opening, from a first transverse width at the upper surface of the link end to a second transverse width at the center of the pivot rod opening. From there, the link ends have a uniform transverse width extending to the lower module surface. The transverse width of the upper surface of the link ends is such that when adjacent links are coupled together by a pivot rod, the intercalated modules provide a gap-free upper surface between adjacent link ends in the transverse direction, aligned with the pivot rod. This structure completely covers the pivot rod from the upper module surface while the beveled structure exposes portions of the pivot rod from the lower surface for cleaning.
Patent CA-2372688-A1 (CA)
Title: Device and method for infusion of small molecule insulin mimetic materials
Inventor: VAN ANTWERP WILLIAM P
IPC: A61M1/36
Filed: 2000-05-10
Abstract: A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual includes a housing, a reservoir and a controller. The housing contains a driving mechanism, and the reservoir is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual. The controller controls the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual. Preferably, the medication delivery device is an infusion pump. In particular, the driving mechanism is a syringe type drive actuator, or a gas generator. The driving mechanism may also utilize iontophoresis or passive trans-dermal delivery. In addition, the driving mechanism is controlled to infuse the small molecule insulin mimetic material in a continuous, near-continuous, intermittent and pulsatile manner. The driving mechanism may also be controlled to deliver discrete, user settable boluses.    Preferably, the small molecule insulin mimetic material is L-783,281. Also, the small molecule insulin mimetic material may be an analog of L-783,281.      In addition, the small molecule insulin mimetic material may be infused with at least one additional component such as insulin, insulin analogs and insulin related peptides. Preferably, the small molecule insulin mimetic material binds to .beta. sub-units of an insulin receptor site. However, the small molecule insulin mimetic material may bind to .alpha. sub-units of an insulin receptor site. Alternatively, the small molecule insulin mimetic material is a trans-membrane insulin mimetic material that binds to at least one .beta. sub-unit and at least one .alpha. sub-unit of an insulin receptor site.
Patent CA-2373087-A1 (CA)
Inventor: ROLLSTON BRIAN
IPC: F01B3/04
Filed: 2000-04-13
Abstract: A drive mechanism (20) for use in the transmission of power from a plurality of linear reciprocating power generating elements (14) to a rotating output element (60). The drive mechanism (20) includes a drive cam member (21) having a cam follower guiding contour (30) extending along the cam member (21); a drive cam follower (31) operatively connected to each power generating element (14). Each follower (31) is adapted to engage the cam follower guiding contour (30) throughout each reciprocation cycle of the power generating elements (14), the drive cam follower guiding contour (30) following a generally sinusoidal profile on the surface of the drive cam member (21), the profile including a series of lobes (25, 26) forming peaks and troughs with intermediate regions (27, 28) therebetween, the peak to peak amplitude of the substantially sinusoidal profile of the cam follower guiding contour (30) on the surface of the drive cam (21) substantially corresponding to the stroke amplitude of the stroke of the reciprocating power generating elements (14).  There are at least three drive cam followers (31) spaced along the contour (30) from one peak to an adjacent trough. A rotary vane displacer for a gamma form Stirling engine is also described.
Patent CA-2376026-A1 (CA)
Inventor: REID LAWRENCE
IPC: A61F13/08
Filed: 2000-06-23
Abstract: A multilayer compression stocking or bandage system comprises a plurality of layers, including an underlayer and at least one overlayer, each of which may have predetermined amounts of compressive pressure at discrete locations. In one aspect, the underlayer has one or more alignment markings, each positioned at a different location on the underlayer to assist in aligning discrete locations of compressive pressure on the lower extremities. In another aspect, each of the layers has one or more alignment markings, each alignment marking positioned at a different location on the respective layer, and each alignment marking on a layer corresponds to a different one of the alignment markings on each other layer. When alignment markings on each layer are aligned with corresponding markings on each other layer, discrete locations of specific amounts of compressive pressure on each layer can be properly aligned, resulting in accurate higher pressures at particular anatomical locations and proper pressure gradations along the length of the leg.
Patent CA-2376789-A1 (CA)
Title: A process for improving search engine efficiency using user feedback
Inventor: PERKINS ALAN
IPC: G06F17/30
Filed: 2000-06-14
Abstract: A process for refining the results of a query to an Internet search engine database by the use of user feedback is disclosed. It is a method to allow a user to rate the relevancy of URLs returned for a specific query. The relevancy ratings for a specific query are combined by the Internet search engine with data from a user profile of personal information defined by the user (106). The Internet search engine can determine which items of data in the profile are common between users who have rated a query result highly. The search engine can then modify the search algorithm (107) to return those URLs rated highly by users with common profile attributes (108). The benefit to the Internet is more efficient searching and retrieval of information for users.
Patent CA-2378637-A1 (CA)
Title: Beam structure and method for producing such structures
Inventor: KERGEN RICHARD
IPC: E04C3/04
Filed: 2000-07-05
Abstract: The invention concerns a beam structure comprising at least a wing (1, 1') made of at least a first metal and at least a core (2, 2') made of at least a second metal, said core being assembled substantially perpendicular to said wing and said core being a sheet material or sheet metal. The invention is characterised in that the first metal has a high or very high yield strength, and associated with a yield strength/tensile strength ratio close to 1, the second metal has a yield strength substantially lower than that of the first metal; the second metal has a yield strength/tensile strength ratio substantially less than 0.9 and less than the value of said ratio exhibited by the first metal.
Patent CA-2381372-A1 (CA)
Title: Four port variable load valve weigh system for a brake pipe controlled brake system
Inventor: WOOD JAMES A
IPC: B60T13/66
Filed: 2002-04-10
Abstract: A pneumatic system serves as a backup to the electronic system that normally provides load compensation on a railcar truck during both service and emergency applications of the brakes. The pneumatic system compensates for the load railcar bears during service and emergency brake applications whenever the electronic load compensation system fails due to a loss of power or other electrical failure. Ideal for railcar trucks equipped with brake pipe controlled brake equipment, the pneumatic system provides load compensation through use of a four-port variable load valve in combination with a low complexity MC-30A-1 control valve.
Patent CA-2381396-A1 (CA)
Inventor: SHIMKETS RICHARD A
IPC: A61K48/00
Filed: 2000-08-11
Abstract: The invention provides polypeptides, designated herein as PROX polypeptides, as well as polynucleotides encoding PROX polypeptides, and antibodies that immunospecifically-bind to PROX polypeptides or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the PROX polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.