baber/WOPTO huggingface dataset:
Patent IL-108507-A0 (IL)
Title: Substituted phenyl sulfonamides, their preparationand pharmaceutical compositions containing them
IPC: A61K31/34
Filed: 1994-02-01
Abstract: Substituted phenylsulphonamides having the formula: <CHEM>  where the variables are as defined in Claim 1;   are selective beta-3 adrenergic receptor agonists with very little beta-1 and beta-2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have very potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to reduce triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to reduce gut motility. In addition, the compounds can be used to reduce neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenylsulphonamide with an appropriately substituted alkyl epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for reduction of triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
Patent IL-117226-A0 (IL)
Title: Composition for controlling parasites
IPC: A01N43/90
Filed: 1996-02-22
Abstract: The present invention relates to a composition for controlling parasites, in and on animals, which comprises, as active ingredient, a combination, in variable proportions, of at least one parasiticidally active compound, in free form or in salt form, selected from the N-phenyl-N'-benzoyl-urea class of substances, and at least one parasiticidally active compound, in free form or in salt form, selected from the milbemycin, avermectin, milbemycin oxime, moxidectin, ivermectin, abamectin and doramectin classes of substances and the derivatives thereof; to a method of controlling these pests; to a process for the preparation of this composition; and to the use of this composition.
Patent IL-117700-A0 (IL)
Title: Polymerizable perfluoroalkylether siloxane macromer
IPC: C08G18/81
Filed: 1996-03-28
Abstract: A macromonomer of the formula (I): Q-PFPE-L-M-L-PFPE-Q is described, wherein Q may be the same or different and is a polymerizable group, PFPE may be the same or different and is a perfluorinated polyether of formula (II): -CH2CF2O(CF2CF2O)x(CF2O)yCF2CH2O-, wherein the CF2CF2O and CF2O units may be randomly distributed or distributed as blocks throughout the chain and wherein x and y may be the same or different such that the molecular weight of the PFPE is in the range of from 242 to 4,000, L may be the same or different and is a difunctional linking group; and M is a residue from a difunctional polymer or copolymer wherein M has a molecular weight of 180 to 6000 comprising silicone repeat units of formula (III), where R<1> and R<2> may be the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, halosubstituted alkyl, and the like. The macromonomer may be used in the production of contact lenses, corneal implants, cell growth substrates or medical implants.
Patent IL-130787-A0 (IL)
Title: Method and apparatus for providing authentication security in a wireless communication system
IPC: H04W12/06
Filed: 1997-12-19
Abstract: An apparatus for providing authentication of a mobile station in a wireless communication system. The present invention takes the number dialed by the mobile station user and computes the 24 bit number (AUTH-DATA) for authentication in accordance with a hashing function that has the following characteristics. The hashing function takes as its input at least the entire dialed digit string contained in the request for service and the number of digits. In a preferred embodiment, the ordering of the digits affects the result, as well as, the values of the digits. The preferred embodiment of the hashing function also accepts some or all of the mobile station identifier data. The function provides as output a number of suitable size for input to a second calculation of an authentication signature, such as the 24 bits required for AUTH-DATA. The output number is created in such a way that there is a minimum likelihood that other sets of dialed digits may create the same result.
Patent IL-134723-A0 (IL)
Title: Amide derivatives for the treatment of diseases mediated by cytokines
IPC: A61P43/00
Filed: 1998-09-17
Abstract: The invention concerns the use of amide derivatives of formula (I) wherein: R<1 >and R<2 >are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3; R<3 >is C1-4alkyl; q is 0-4; and R<4 >is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines
Patent IL-139052-A0 (IL)
Title: Acid-base polymer blends and their use in membrane processes
IPC: C08L71/10
Filed: 1999-04-16
Abstract: The present invention relates to polymer blends and polymer blend membranes which consist of a polymeric sulfonic acid and of a polymer which contains primary, secondary or tertiary amino groups, which are prepared via mixing of a salt of the polymeric sulfonic acid with the polymer which contains primary, secondary or tertiary amino groups. The invention further relates to the use of polymer blend membranes in membrane fuel cells, polymer electrolyte membrane fuel cells (PEM fuel cells) or direct methanol fuel cells (DMFC), in membrane electrolysis, in aqueous or non-aqueous electrodialysis, in diffusion dialysis, in the perstractive separation of alkenes from alkene/alkane mixtures (here the membranes are in the SO3Ag form, where the Ag<+> forms a reversible complex with the alkene (->facilitated transport)), in pervaporative separation of water from water/organics mixtures, or in gas separation.
Patent IL-145310-A0 (IL)
Title: Vascular adhesion molecules and modulation of their function
IPC: C07H21/00
Filed: 2000-03-13
Abstract: The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70% sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 or 2 (CRAM-1 or CRAM-2) as depicted in   Fig 3   upper and second row, respectively, and antibodies thereto as well as their use in treatment of inflammation and tumors.
Patent IL-157742-A0 (IL)
Title: A kit and method for detecting fecal parasites
IPC: G01N33/543
Filed: 2002-03-12
Abstract: The invention concerns a home kit and a method for detection of the presence of a fecal parasite in a stool.
Patent IL-163698-A0 (IL)
Title: Improved method for the production of 4-(6-bromohexyloxy)butylbenzene
IPC: C07B61/00
Filed: 2003-02-28
Abstract: The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.
Patent IL-163748-A0 (IL)
Title: Cathepsin cysteine protease inhibitors
IPC: C07D213/70
Filed: 2003-02-28
Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
Patent IL-178133-A0 (IL)
Title: Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
IPC: A61P1/00
Filed: 2006-09-17
Abstract: Nifedipine, optionally in combination with bethanechol, is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and haemorrhoids. The agents induce a reduction in the mean and resting pressure, thereby assisting in the healing of anal fissures and haemorrhoids. Optionally, the active agents may be co-administered with a steroid, such as hydrocortisone.
Patent IL-179030-A0 (IL)
Title: Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
IPC: C07D409/06
Filed: 2006-11-02
Abstract: The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I) The new compounds are useful for the treatment or prophylaxis of the central nervous system, the gastrointestinal system or the cardiovascular system.
Patent IL-192137-A0 (IL)
Title: Formulations useful in the treatment of male and female impotence
IPC: A61K31/352
Filed: 2008-06-12
Abstract: Pharmaceutical compositions containing:  extracts of  Tribulus terrestris, Epimedium koreanum, Cinnamon cassia  in the weight ratio of 1.5-3.5 : 1-2 : 0.1-0.4 respectively; 
and optionally  arginine or a physiologically equivalent ester, salt or precursor thereof.    The compositions of the invention are useful in the treatment of male and female sexual dysfunctions.
Patent IL-212867-A0 (IL)
Title: Use of a fusion construct comprising an amino acid sequence of a tissue inhibitor of metalloproteinases (timp) or a biologically active fragment thereof, which is linked to a glycosylphosphatidylinositol (gpi)-anchor, for the preparation of medicaments for thetreatment of a skin lesion to prevent or inhibit the formation of a scar
Filed: 2011-05-12
Abstract: The present invention relates to the use of fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) for the treatment of cancer. In one embodiment, the TIMP is linked to mucin followed by GPI for surface membrane presentation. The invention further relates to the use of TIMP-GPI or TIMP-mucin-GPI for inhibiting cancer cell proliferation both in vitro and in vivo. The GPI-anchored TIMP proteins are incorporated in the surface membrane of tumour cells and render tumour cells sensitive to FAS-induced apoptosis. This approach makes the GPI-anchored TIMPs useful as anti-cancer agents for the treatment of cancer, and, in particular, residual cancer after incomplete surgical resection of primary tumours in an individual.
Patent IL-219732-A0 (IL)
Title: Use of 4 - (amino)-2-(2-6-dioxo(3-piperidyl))-isoindoline-1,3-dione in manufacture of a pharmaceutical composiiton for treating multiple myeloma
IPC: A61P27/14
Filed: 2012-05-10
Abstract: Methods of treating, preventing and/or managing cancer as well as diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Patent RO-129104-A0 (RO)
Title: Float turbine -3-
Inventor: CARNU ION
IPC: F03B3/06
Filed: 2013-06-20
Abstract: The invention relates to a turbine with floats 3 employed to produce energy. According to the invention, the turbine comprises a support (1) provided at its ends with some drums (2) having some guiding channels (3) which accommodate some guides (5) of a conveyor belt (4) on which some float syringes (7) are attached with some collars (16) and are coupled to the common hose (6) by means of some small hoses (15), each of the said syringes (7) being provided with a chamfering (8) while, for the heads (10) of the piston rods (9), there are provided on the support (1) some nose locks having some springs (13), a lock (11) in the upper part and another lock (12) in the lower part, which also has a double lever (14), additionally there being provided some safety members (17) with some springs (18) and some obstacles (19 and 20).
Patent RO-131173-A0 (RO)
Title: Multipurpose terminal for video-intercom installations
Inventor: BERDAN MARIAN
IPC: H04N7/18
Filed: 2015-10-29
Abstract: The invention relates to a multipurpose terminal for video-intercom installations mounted inside buildings for controlling the access of outsiders into the building and also for effraction warning, for warning in case of hazardous situations as well as for disconnecting the electric consumers within the protected areas when an event occurs. According to the invention, the multipurpose terminal consists of a flat parallelepipedal casing having on the frontal side: a keyboard, a video display, a microphone and a loudspeaker, and inside having electronic control and memory circuits and circuits achieving the functions of video-intercom, access control, event warning, RFID reader for arming/disarming, a wireless communication module, connectors for making the connections to the video-intercom installation as well as to some movement, broken window, open door, flood, smoke and gas sensors, within the protected area.
Patent RO-135935-A0 (RO)
Title: Polymeric solutions for chemical and radiochemical decontamination and process for preparing the same
Inventor: JERCA FLORICA ADRIANA
IPC: G21F9/28
Filed: 2021-03-26
Abstract: The invention relates to a process for preparing polymeric aqueous solutions for the (radio)chemical decontamination of surfaces contaminated with toxic agents. According to the invention, the process consists in physically mixing, in an aqueous medium, at ambient temperature, polyvinyl alcohol (APV) with a degree of hydrolysis lower than 90% or chemically modified APV having a molar content of 5...10% cinnamic acid, with three or four of the following additives: 0.5% by mass ethylenediaminetetraacetic acid, 2.5% by mass hydroxypropyl methylcellulose, 2% by mass poloxamer F68, 0.03% by mass dye and/or 5 % by volume glycerin. Thus, polymer aqueous solutions with a wide range of viscosities and rheological properties suitable for the multipurpose decontamination of metal or ceramic, smooth or porous, plane or vertical surfaces are obtained by deposition of biodegradable exfoliating films by spraying, spreading or immersion.
Patent AP-2004002952-A0 (AP)
Title: N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds.
Inventor: GAILUNAS ANDREA
IPC: C07C233/40
Filed: 2002-07-11
Abstract: Disclosed are compounds of the formula (I): useful in treating Alzheimer' s disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical composition and methods of treatment to reduce A beta peptide formation.
Patent AU-2002951738-A0 (AU)
Title: Feedthrough with extended conductive pathways
IPC: H01R43/24
Filed: 2002-09-30
Abstract: A method (10) of forming an electrically conducting feedthrough. The method (10) comprises a first step (11) of forming an electrically conductive structure (21) comprising a sacrificial component and a non-sacrificial component. At least a portion of the non-sacrificial component can then be coated with a relatively electrically insulating material (35) prior to removal of at least a portion of the sacrificial component from the electrically conductive structure. The structure of the feedthrough provides electrical connection through the wall of a housing of an implantable component while preventing unwanted transfer of materials between the interior of the component and the surrounding environment.
Patent MC-2286-A1 (MC)
Inventor: MICHAEL R SCHINITSKY
IPC: A61K8/27
Filed: 1990-05-25
Abstract: The depth of wrinkles in skin (caused by intrinsic or photo-induced ageing) is reduced by topical applicn. of a compsn. comprising 20-20 % ascorbic acid (I), 1-10% tyrosine (II), and 0.5-5 % of a non-toxic Zn salt (III) in a non-toxic carrier. Comprises the applicn. of the compsn. once or twice a day. The prefd. (III) is ZnSO4. Prefd. compsns. contain 5-15% (I), 3-8% (II), and 1-2% ZnSO4.
Patent ZW-1185-A1 (ZW)
Title: Skin care compositions
Inventor: ISAACSON DAVID M
IPC: C07C327/06
Filed: 1985-01-17
Abstract: A skin care composition having improved effectiveness in preventing and treating acute inflammatory skin conditions comprising miconazole nitrate and zinc oxide.
Patent LU-85439-A1 (LU)
Inventor: PELERIN JACQUES
IPC: C08J11/06
Filed: 1984-06-28
Abstract: 1. A process for causing the adhesion to a substrate of a polymeric material consisting of a homogeneous mixture comprising at least 20% by weight of a regenerated polymeric substance and at least 1% by weight of cellulose fibres, characterized in that the homogeneous mixture also contains a polyolefin modified by a monomer selected from the group comprising unsaturated carboxylic acids, the corresponding anhydrides and derivatives thereof, and in that the proportion of modified polyolefin is such that there is adhesion between the substrate and the polymeric material and such that this proportion of modified polyolefin is less than 10% by weight, based on the said homogeneous mixture.
Patent MA-21098-A1 (MA)
Inventor: NICHOLAS FELDMAN
IPC: C10L1/222
Filed: 1987-10-30
Abstract: A gasoline composition contains a minor amount of at least one of a specified group of quaternary ammonium hydroxides for decreasing or reversing the octane requirement increase (ORI) for a fuel-fired spark ignition internal combustion engine. Tetrabutylammonium hydroxide and tricaprylicmethylammonium hydroxide are two preferred compounds for use.
Patent MA-22039-A1 (MA)
Inventor: D G SCHMIDT
IPC: A61K8/00
Filed: 1990-05-10
Abstract: Perfume particles comprise perfume dispersed within certain water-insoluble polymeric carrier materials and encapsulated in a protective shell by coating with a friable coating material. The coated particles allow for preservation and protection of perfumes which are susceptible to degradation or loss in storage and in harsh cleaning conditions. In use, the surface coating fractures and the underlying carrier/perfume particles efficiently deliver a large variety of perfume types to fabrics or other surfaces.
Patent MA-27180-A1 (MA)
Title: N-aryl-2-oxazolidinone-5-carboxamides et leurs derives, et leur utilisation comme agents antibacteriens
Inventor: THOMAS RICHARD C
IPC: C07D417/04
Filed: 2004-08-24
Abstract: DEPOSANT Société dite: PHARMACIA & UPJOHN COMPANY REVENDICATION DE PRIORITES US	25 Février 2002	60/359,495 Voir en annexe le titre de l'invention et le texte de l'abrégé N-aryl-2-oxazolidinone-5-carboxamides et leurs dérivés, et leur utilisation comme agents antibactériens Les composés de formule B-C-A-CO-NH-R1 dans laquelle A a la structure i, ii ou iii, de formule (I), (II) ou (III), C représente un groupe aryle ou hétéroaryle facultativement substitué et B représente un groupement cyclique spécifié, ou bien C et B, conjointement, représentent un groupement hétérobicyclique, sont utiles comme agents antibactériens.
Patent MA-46814-A1 (MA)
Title: Anticorps anti-lag3 radiomarqués pour imagerie immuno-pet
Inventor: THURSTON GAVIN
IPC: C07K16/28
Filed: 2018-02-09
Abstract: L'invention concerne des anticorps anti-lag3 radiomarqués et leur utilisation dans l'imagerie immuno-pet. L'invention concerne également des procédés de détection de la présence des protéines lag3 chez un patient ou dans un échantillon.
Patent MA-54973-A1 (MA)
Title: Récepteur solaire asymétrique
Inventor: CARRASCOSA PÉREZ MARCO ANTONIO
IPC: F24S20/20
Filed: 2020-05-08
Abstract: L'invention porte sur un récepteur solaire asymétrique (13) approprié pour être installé dans des centrales solaires à tour d'héliostat (11), ledit récepteur (13) étant conçu pour couvrir au moins une région angulaire de 180° autour d'une tour (12), et la densité de surface effective du récepteur (13) pour recevoir le rayonnement variant en fonction de son orientation sur sa région angulaire couverte. La surface effective dudit récepteur (13) est de préférence constituée d'un ou de plusieurs panneaux et, de préférence encore, le récepteur (13) comprend au moins deux panneaux, au moins l'un des panneaux comprenant une hauteur plus petite que les autres panneaux. L'invention concerne également une tour solaire (12) comprenant ledit récepteur (13), un champ solaire comprenant ladite tour (12), une centrale solaire comprenant ledit champ solaire, et un procédé d'installation d'un champ solaire.
Patent UY-25863-A1 (UY)
Title: Polimorfos de acido 2-(3-ciano-4-isobutiloxi fenil)4-metil 5 - tiazol carboxilico y metodo de produccion de los mismos.
Inventor: KITAMURA MITSUTAKA
Filed: 1999-12-17
Abstract: La presente invención provee una técnica para producir selectivamente un polimorfo deseado de ácido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxílico. La presente invención provee también un método para producir varios polimorfos de ácido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxílico que comprende cristalizar bajo las condiciones definidas por una temperatura específica y una composición de un sovente mixto de metanol y agua, y los polimorfos obtenidos por el método. La presente invención provee además un método para producir los otros compuestos polimorfos o amorfos mediante secado de un polimorfo específico bajo presión reducida con calentamiento, y los otros compuestos polimorfos a amorfos mediante secado de un polimorfo específico bajo presión reducida con calentamiento, y los otros compuestos polimorfos o amorfos obtenidos mediante el método.
Patent UY-27485-A1 (UY)
Title: Compuestos pirimidina de anillo fusionado alquinilado
Inventor: BERNARD GAUDILLIERE
IPC: A61K31/517
Filed: 2002-10-11
Abstract: Compuesto inhibidor de metaloproteasa de fórmula: donde W1 es oxígeno , azufre, -NR3 y otros; W2 es hidrógeno, trifluorometilo, amino, alquilo y otros; X1, X2, y X3 son nitrógeno, carbono, carbono sustituido y otros; n es 0 a 8, q es 0 a 7; Z es -CR12 R13; A es arilo, heteroarilo, cicloalquilo y heterociclo y otros; R1 es hidrógeno. Proceso de preparación, composición farmacéutica y usos del mismo.
Patent UY-27559-A1 (UY)
Title: Derivados del benzotiazol.
Inventor: RIEMER CLAUS
IPC: A61P9/10
Filed: 2002-11-28
Abstract: La presente invención se refiere a compuestos de fórmula general en donde R1 es hidrógeno o alquilo inferior; R2 es alquilo inferior, -( CH2) n - alquilo inferior, NR'2; R' es hidrógeno, alquilo inferior ó -(CH2) n - O- alquilo inferior, independientemente estre sí para R'2, ó R'2 puede formar juntamente con el átono de N un anillo de pirrollidina; n es 1, 2ó 3; y a sales de adición ácida farmacéuticamente aceptables de los mismos. Se ha descubierto sorprendentemente que los compuestos de fórmula general I son ligados del receptor de la adenosina. Especialmente, los compuestos de la presente invención tienen una buena afinidad para el receptor A2 A y por lo tanto son útiles en el tratamiento de enfermedades relacionadas con este receptor.
Patent UY-29495-A1 (UY)
Title: Anticuerpos contra miostatina
Inventor: GREEN LARRY L
IPC: A61K39/395
Filed: 2006-04-24
Abstract: La invención se relaciona a anticuerpos humanos y porciones de unión al antígeno de los mismos, que se unen a miostatina para inhibir la miostatina; a anticuerpos anti-miostatina humanos; a anticuerpos que son quiméricos, biespecíficos, derivatizados; a cadenas pesada y liviana aisladas de inmunoglobulinas derivadas de anticuerpos anti-miostatina humanos; y a las moléculas de ácido nucleico que codifican dichas inmunoglobulinas. Se describen métodos para elaborar los anticuerpos anti-miostatina humanos; composiciones que los comprenden; y métodos de diagnóstico y tratamiento. La invención también provee métodos para una terapia génica humana y se relaciona con animales o plantas transgénicas que comprenden las moléculas de ácido nucleico de la presente invención.