baber/WOPTO huggingface dataset:
Patent PT-103676-B (PT)
Title: Processo de bioconversão de resíduos de fruta na sua co-digestão anaeróbia com chorumes animais, para utilização na produção de metano e valorização agronómica de fluxos efluentes de agro-pecuárias e retiradas de fruta do mercado
Inventor: FERREIRA LUIS JORGE MARTINEZ
IPC: C12P5/02
Filed: 2007-03-08
Abstract: O PRESENTE INVENTO DIZ RESPEITO A UM PROCESSO DE BIOCONVERSÃO DE RESÍDUOS DE FRUTA NA SUA CO-DIGESTÃO ANAERÓBIA COM CHORUMES ANIMAIS, PARA UTILIZAÇÃO NA PRODUÇÃO DE METANO E VALORIZAÇÃO AGRONÓMICA DE FLUXOS EFLUENTES DE AGRO-PECUÁRIAS E DE RETIRADAS DE FRUTA DO MERCADO. O PROCESSO DE BIOCONVERSÃO DECORRE EM FERMENTADORES EM REGIME HIDRÁULICO DESCONTÍNUO COM AGITAÇÃO MECÂNICA (5), EM CONDIÇÕES ANÓXICAS E À TEMPERATURA AMBIENTE. O MEIO FERMENTATIVO CONSISTE ESSENCIALMENTE NUMA MISTURA DE RESÍDUOS DE MAÇÃS E PÊRAS PREVIAMENTE POLPADOS ATRAVÉS DE UM MOINHO DE FRUTA (2). O PROCESSO DE BIOCONVERSÃO FOI CARACTERIZADO, NO QUE DIZ RESPEITO AO TIPO DE FERMENTAÇÕES OCORRIDAS. O DESAPARECIMENTO DOS AÇÚCARES, A PRODUÇÃO DE METABOLITOS PRIMÁRIOS E A ESTABILIDADE DO PRODUTO FINAL FORAM SEGUIDAS AO LONGO DO TEMPO, TENDO-SE CONCLUIDO QUE O PRODUTO FINAL É ESTÁVEL E SE MANTÉM CONSERVADO POR LONGOS PERÍODOS DE TEMPO, SEM PERDER QUALIDADE. O PASSO DA BIOCONVERSÃO NA UTILIZAÇÃO DOS DITOS RESÍDUOS DE FRUTA, COMO CO-SUBSTRATO NUM PROCESSO DE CO-DIGESTÃO ANAERÓBIA COM CHORUMES (3), (5), (6), (7), CONFERE ESSENCIALMENTE O GRAU DE NOVIDADE A ESTE INVENTO.
Patent PT-107909-B (PT)
Title: Sistema modular e de ligação rápida de unidades de habitação móveis
Inventor: ANDRÉ CUNHA FERNANDES
IPC: E04B1/348
Filed: 2014-09-23
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UMA ESTRUTURA MODULAR DE LIGAÇÃO RÁPIDA DE MÓDULOS HABITÁVEIS BASEADA NA ACOPLAGEM DE CONTENTORES NORMALIZADOS A ESTRUTURAS ADAPTADAS À SUA RECEÇÃO. ESTE SISTEMA BASEIA-SE NUM SISTEMA DE PLACAS CONETORAS (1), MÓDULOS HABITÁVEIS (2), UMA ESTRUTURA RECETORA (3), UM ALVÉOLO (7) DE LIGAÇÃO À REFERIDA ESTRUTURA RECETORA E SISTEMAS AUTOMÁTICOS DE TRANSPORTE (5), ELEVAÇÃO (4), ATRACAMENTO E ACOPLAGEM. A PRESENTE INVENÇÃO ENGLOBA AINDA UM MÉTODO DE LIGAÇÃO RÁPIDA DE MÓDULOS HABITÁVEIS NESTA ESTRUTURA MODULAR.
Patent PT-110352-B (PT)
Title: Mecanismo de engrenagens desmultiplicadoras para a secagem de esfregona por centrifugação e o seu método de funcionamento
Inventor: PAULO MIGUEL NOGUEIRA PEÇAS
IPC: A47L13/58
Filed: 2017-10-18
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM MECANISMO DE SECAGEM DE UMA ESFREGONA POR CENTRIFUGAÇÃO MOTORA COMPOSTO POR UM CONJUNTO DE ENGRENAGENS DESMULTIPLICADORAS. O SEU ACIONAMENTO É FEITO POR IMPULSOS DESCENDENTES VERTICAIS, EXERCIDOS NA ESFREGONA (1), QUE EMPURRAM O CESTO (2). CONSEQUENTEMENTE, O CESTO (2) ACIONA O SISTEMA DE CREMALHEIRA (3), QUE ATIVA A ENGRENAGEM CÓNICA (4). ESTA ALTERA O MOVIMENTO DE ROTAÇÃO PARA A HORIZONTAL, PROVOCANDO O ENGRENAMENTO DA ENGRENAGEM CILÍNDRICA INFERIOR (5). NA LIGAÇÃO ENTRE ESTA E A ENGRENAGEM CILÍNDRICA SUPERIOR (6) ESTÁ INCORPORADO O SISTEMA DE ROQUETE (7), LIMITANDO A ENGRENAGEM CILÍNDRICA SUPERIOR (6) A UMA ROTAÇÃO UNIDIRECIONAL. ESTA ÚLTIMA, PELO VEIO DENTADO (8), CONECTA-SE AO CESTO (2), LIMITANDO O CESTO (2) A UM MOVIMENTO TRANSLACIONAL VERTICAL E PERMITINDO A SUA ROTAÇÃO EM SIMULTÂNEO, FECHANDO O MECANISMO. O MECANISMO É PASSÍVEL DE FABRICAÇÃO, SENDO MAIORITARIAMENTE COMPOSTO POR PEÇAS PLÁSTICAS INJETADAS.
Patent RO-84259-B (RO)
Title: Circuit for memorizing information in data transmission terminals on telephone lines
Inventor: SASS SZILARD
IPC: H04L13/08
Filed: 1980-11-12
Abstract: 1. Circuit arrangement for the storage of information in technical data-transmission subscriber stations, which comprises a data-word store unit (KE), a block store unit (BE) connected to its output and comprising a block store sub-unit (BT) with output connected as a feed-back to its own input, as well as a control and delay unit (VIE) connected to the data-word store unit and to the block store unit, characterized in that the data-word store unit (KE) comprises a first data-word store sub-unit (KT1) and a second data-word store sub-unit (KT2) connected in series, and in that there is provided a data-word store control sub-unit (KTV) which is connected to the first data-word store sub-unit (KT1) by way of a first decoder (D1) and to the second data-word store sub-unit (KT2) by way of a second decoder (D2).
Patent RO-82502-B (RO)
Title: Process for preparing hexahydroindazol-izokinoline-6-substitute
Inventor: KORNFELD EDMUND CARL
IPC: C07D221/14
Filed: 1982-03-18
Abstract: 8-dimethylaminomethylene compounds of the formula <CHEM>  wherein R is H, benzyl, (C1-C3)alkyl or allyol; and R<4> and R<5> are independently H or (C1-C3)alkoxy; and  7-oxo-hexahydrobenzo[de]quinolines of the formula <CHEM>  wherein  R<7> is (C1-C3)alkyl, ally, or benzyl; R<4> and R<5> are independently (C1-C3)alkoxy, or H, with the limitation that when R<4> and R<5> are both (C1-C3)alkoxy, then R<7> can not be methyl; are intermediates useful in the preparation of 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines, having dopamine agonist and dopamine antagonist activity.
Patent RO-91352-B (RO)
Title: Process for the preparation of s(-)-3[acetyl-4-(tertbutylamino- 2-hydroxypropoxy) -phenyl]-1,1-diethylurea
Inventor: ZOLSS GERHARD
IPC: C07D303/22
Filed: 1985-03-15
Abstract: 1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) S(-)-3-[3-acetyl-4-(3-tert.butylamino-2-hydroxypropoxy) phenyl]-1,1-diethylurea (S(-)-celiprolol) and its pharmaceutically acceptable acid addition salts. 1. Claims (for the Contracting State AT) Process for the preparation of S(-)-3-[3-acetyl-4-(3-tert.butylamino-2-hydroxypropoxy) phenyl]-1,1-diethylurea (S(-)-celiprolol) and its pharmaceutically acceptable acid addition salts, characterised in that a) the racemate of the formula  see diagramm : EP0155518,P10,F1  in the form of the base is reacted with an enantiomer of a chiral resolving acid in a suitable organic solvent, the mixture of the two diastereomeric salts formed in this manner is separated by fractional crystallisation, and, after separating each diastereomeric salt which contains the laevorotatory enantiomer of the compound of the formula I in the S configuration, is reconverted into the free base or a pharmaceutically acceptable addition salt and the resolving acid is recovered, or b) S(+)-3-[3-acetyl-4-(2,3-epoxypropoxy)-phenyl]- 1,1-diethylurea of the formula  see diagramm : EP0155518,P10,F2  is reacted with tertiary butylamine in the presence of water at room temperature or with gentle heating to a maximum of 40 degrees C, and then the laevorotatory enantiomer of the compound of the formula I thus obtained is converted as required into a pharmaceutically acceptable addition salt.
Patent TW-200509-B (TW)
IPC: C09D133/04
Filed: 1992-04-02
Granted: 1993-02-21
Abstract: The invention describes a new type of multi-functional water-dispersible crosslinking agents. These crosslinking agents are products consisting of oligomeric and compounds containing carbodiimide functions and other reactive functional groups. Further the invention describes aqueous dispersions, emulsions or solutions with such crosslinking agents. Finally the invention comprises a process for the preparation of the crosslinking agent according to the invention.
Patent TW-203547-B (TW)
IPC: A01P3/00
Filed: 1992-04-06
Granted: 1993-04-11
Abstract: The novel active substance mixtures of 
 
  A) 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)- butan-2-ol of the formula 
<IMAGE>
 and/or
 1-(4-phenylphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-ol of the formula 
<IMAGE>
 and 
  B) 4-(2,2-difluoro-1,3-benzodioxol-7-yl)-1H-pyrrole-3-carbonitrile of the formula 
<IMAGE>
 
 are distinguished by very good fungicidal properties.
Patent TW-309425-B (TW)
IPC: C07C271/10
Filed: 1992-05-29
Granted: 1997-07-01
Abstract: 1-Hydroxy-2-naphthalene carboxylate (hydroxynaphthoate) salt of 4-hydroxy- alpha <1>-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3- benzenedimethanol in the form of spherical accretions of microcrystals, the spherical accretions being free-flowing, friable and micronisable and preferably having a mean particle size from 70 to 300 mu m and a mean surface area from 4 to 12m<2>g-<1>. The hydroxynaphthoate salt (in the claimed form) may be prepared by quenching a hot organic/aqueous organic solution containing the salt with a cold organic/aqueous organic solvent.
Patent TW-232691-B (TW)
IPC: A61K31/415
Filed: 1992-08-22
Granted: 1994-10-21
Abstract: The novel 4-oxocyclic ureas and the pharmaceutically- acceptable salts and esters thereof of the present invention are useful as antiarrhythmic and antifibrillatory agents and have following general structure: <CHEM> wherein  (a) X is a saturated or unsaturated, 5-, 6-, or 7-membered heterocycle or carbocycle; (b) R is selected from the group consisting of covalent bond, nil, heteroatom, carbonyl, heterocyclic ring, carbocyclic ring, alkyl, alkenyl, alkoxy, alkylamino, arylalkyl, aryloxy, acyl, acyloxy, and acylamino; (c) Y is a substituted or unsubstituted, saturated or unsaturated, 5-, 6-, or 7-membered heterocyclic ring or carbocyclic ring, or is nil;  and wherein when R is nil, X and Y are fused ring systems; and when R is a covalent bond, X and Y are ring systems linked through a covalent bond; and when Y is nil, R is a covalent bond, and X is bound to L through R;  (d) R1, R2, and R3 are independently selected from the group consisting of nil, Cl, F, Br, NH2, CF3, OH, SO3H, CH3SO2NH, COOH, alkoxy, alkyl, alkoxycarbonyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, acylamino and acyloxy; (e) L is selected from the group consisting of alkylamino, alkenylamino, alkylimino, alkenylimino, and acylamino; wherein the nitrogen atom thereof is bound to the nitrogen atom at the 1-position of 4-oxocyclic urea moiety; (f) R4 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkylacyl, and heteroalkyl; (g) A is a substituted or unsubstituted, saturated or unsaturated, straight-chain or branched, C1-C8 heteroalkyl; or a substituted or unsubstituted, saturated or unsaturated heterocycle having 5-, 6-, or 7-members; and A has one nitrogen atom, which is adjacent to R4; and (h) R5 is a substituted or unsubstituted C1 or C2 alkyl.
Patent TW-249804-B (TW)
IPC: A61P3/08
Filed: 1993-07-27
Granted: 1995-06-21
Abstract: mula (I) or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein R0 represents a substituted or unsubstituted aryl group; R1 represents hydrogen or an alkyl group; R2 represents a moiety of formula (a) wherein R4 and R5 each independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl or R4 together with R5 represents (CH2)n wherein n is 2, 3 or 4; T represents hydrogen, nitrile or a group -CO.Rs wherein Rs represents hydroxy, alkoxy or a group -NRtRu wherein Rt and Ru independently represent hydrogen, alkyl or Rt and Ru together with the nitrogen to which they are attached represent a saturated heterocyclic group; and R3 represents hydrogen, halogen, alkyl or alkoxy; a process for the preparation of such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine.
Patent TW-233310-B (TW)
Title: A level detection process for furnace bed of high furnace and the device
Inventor: HER JONG-GEN
IPC: C21B7/24
Filed: 1993-10-05
Granted: 1994-11-01
Abstract: A level detection process for furnace bed of high furnace, which comprisesthe following steps: (1) locating two fixed points A and B on the furnace wall, the A point shall be higher than the highest point of the level to be controlled and the B point shall be lower than or equal to the lowest point of the level of the furnace liquid; (2) obtaining the relationship between the quantities of EMF influenced by the temperature difference and heterogeneous temperature distribution among the A and B points to the temperature difference of A, B points; (3) based on the increasing rate of the iron fluid in the operating furnace and the EMF relationship, calculating the quantity of level variation per unit change in EMF (hereinafter referred to as the variation ratio between the level to the EMF); (4) defining the zero level EMF as: subtracting the EMF of previous day when all outlets are closed from the average EMF of temperature difference; (5) filtering out factory noises which are above +1mv or below -1mv and obtaining the level of the operating day according to the following formula: _ h = (EAB - EAB - E0) X m.
Patent TW-310309-B (TW)
IPC: B65D81/03
Filed: 1994-04-21
Granted: 1997-07-11
Abstract: Packaging material for self-supporting packaging container walls can be given the desired flexural rigidity by being laminated to an inherently rigid material such as cardboard. Rigidity can also be achieved if two material layers are fixed at a given spacing from one another. According to the invention, this can be attained in that two material layers (1, 2) define an interjacent chamber (4) which is filled with gas under pressure. The material is produced by the material layers (1, 2) being sealed to one another over a portion of their surface such that a chamber (4) is formed which is filled with, for example, air under pressure. <IMAGE>
Patent TW-344007-B (TW)
Title: Hard synthetic resin foam heat insulating material and method for insulating heat with such heat insulating material
Inventor: YAOSHIRO YASHUNOBU
IPC: E04B1/80
Filed: 1994-10-07
Granted: 1998-11-01
Abstract: An inspection method using pattern matching, which compares the article under inspection with a reference pattern of the article under inspection and calculates their consistency thereby inspectioning whether the shape of the article under inspection is good according to the calculated consistency, the method comprising: a photographing process of separately photographing a plurality of articles under inspection; a reference pattern setting process of setting one of the photographed plurality of articles under inspection as a reference pattern; a calculation process of examining the picture image of the reference pattern and the picture images of the other articles under inspection, and calculating the non-consistency of brightness data for each pixel corresponding to an identical portion of the articles; a mask pattern setting process of finding the pixels of the portion where the non-consistency of the calculated brightness data exceeds a prescribed threshold, and constituting a mask pattern by setting the thus found pixels; and a process of carrying out a pattern matching by inspectioning the picture image of the reference pattern with the picture images of the other articles under inspection after excluding the pixels constituting the mask pattern.
Patent TW-267256-B (TW)
Title: Process for buried bit line
Inventor: LIN JYH-HORNG
IPC: H01L27/112
Filed: 1995-01-23
Granted: 1996-01-01
Abstract: A process of buried bit line, that is applicable to form multiple second type buried bit lines in one firs type silicon substrate, comprises: forming one first oxide covering the silicon substrate; forming multiple parallel and spacing masking layers on the first oxide; forming multiple second oxide filling up between the masking layers; removing the masking layers; forming spacer on lateral side of the second oxide; with the second oxide and the spacer as mask implanting the second type impurity into the silicon substrate to form parallel and spacing second type buried bit lines.
Patent TW-332343-B (TW)
Title: Semiconductor device and method for fabricating the same by irradiating single-crystalline Si substrate with Ne atom to achieve a micromachine with uniform thickness and no junction
Inventor: SHINDOU AKIHIRO
IPC: H01L31/042
Filed: 1995-05-19
Granted: 1998-05-21
Abstract: A method for fabricating a micromachine, which comprises a member in which at least one part of it is split from substrate material, includes the following steps: - step 1: forming a sacrifice layer on the substrate material; - step 2: forming a designated material layer for the member upon the sacrifice layer; - step 3: transferring the designated material layer into single-crystalline layer by emission of plurality of low energy air beams toward the designated material layer form the direction of right angle crossing with plurality of most density crystalline side for generating single-crystalline, when or after step 2 is processed and the optimal temperature is formed for crystallizing and the material is not sputting; - step 4: removing the sacrifice layer after step 3.
Patent TW-431084-B (TW)
Title: Packet data transmission in code-division multiple access communication systems
Inventor: CHEVILLAT PIERRE RENE
IPC: H04J13/00
Filed: 1995-08-17
Granted: 2001-04-21
Abstract: The present system is split into a physical layer (20), a data link layer, and a network layer (24). The data link layer is further split into three parts, namely, data link control (DLC) (23), and two medium access control parts (MAC) (21) and (22). The DLC layer (23) is concerned with link establishment, release and maintenance. The lower MAC part (21) may exist in multiple instances, whereas the upper MAC part (22) is unique. Physically, the two MAC parts (21) and (22) are separated on the network side because the upper MAC part resides in a RNC while the lower part exists in each base station. The connectionless packet service (CLPS) entity (25.1) provides the packet radio service to the mobile user and the CLPS entity (25.2) on the network side provides all facilities required for registration and authentication of mobile users, assigning and administrating their VCls, and interfacing to a packet data network. The CLPS entities (25.1) and (25.2) use the logical link administrators (LLA) (26.x) to initially route messages via a regular dedicated control channel (DCCH) (27.x) to their peer entities. After the MS is attached to the PRCH, all messages exchanged between the CLPS entities (25.x) as well as user data packets are always directed via the respective PRCH (28.x). In this case, the control packets and user data packets are passed through the DLC (29.x) to the packet radio (PR) control entity (30.x). The packets are fragmented and protected with an error control code, e.g. a block code (BC), by a respective unit (31.x) for detecting transmission errors on the receiving side. Then they are convolutionally encoded, interleaved (IL) by the entity (32.x), and transmitted over the PDCH (33). On the receiving side the fragments are reconstructed from the received samples, reassembled to packets, and forwarded to the target CLPS entity (25.2). When the decoder (31.2) delects the receipt of an erroneous packet fragment, an automatic request for repetition (ARQ) scheme provided in the PR control requests its retransmission.
Patent TW-319773-B (TW)
Title: The novel preparation of Re-188 lipiodol
Inventor: CHEN MIIN-NAN
Filed: 1996-02-06
Granted: 1997-11-11
Abstract: A process for preparation of radioactive Lipodol is provided in which ethylenediaminetetraacetic acid is used as a starting material. The acetic solution of the derivative from condensation with 1,2 diaminobenzene performs a redox reaction with Re-188 perrhenate in which ammonia carbonate is added in drops continuously at boiling temperature. Linkage of Re-188 with Lipiodol is formed after incubation at room temperatures for 3 hours. The dissolved acetic acid is expelled from the solution by nitrogen flush in water bath. The final product is an efficacious reagent for hepatoma therapy.
Patent TW-306022-B (TW)
Title: Manufacturing method of metal contact hole for semiconductor integrated circuit
Inventor: TYAN YEU-JONG
IPC: H01L21/31
Filed: 1996-03-04
Granted: 1997-05-21
Abstract: A manufacturing method of metal contact hole for semiconductor integrated circuit, which is applicable to semiconductor substrate with alt least one dielectric, comprises of the following steps: (1) on the dielectric coating one photoresist layer, and by lithography forming one opening one predetermined position; (2) by wet isotropic etching, via the opening etching in the dielectric layer to form one first echoing part; (3) by dry isotropic etching, via the opening expanding the first etching part formed in the dielectric to one second etched part; (4) by dray anisotropic etching, via the opening performing etching to dielectric located on the second etching part bottom to expose the substrate surface, and forming one third etching part, in which the second and the third etching part constitute the metal contact hole.
Patent TW-393531-B (TW)
Title: Hybrid yarn and permanet deformation capable textile material produced therefrom, its production and fiber reinforced shaped article
Inventor: BAK HENNING
IPC: D03D15/50
Filed: 1996-04-20
Granted: 2000-06-11
Abstract: Described are a hybrid yarn consisting of two groups of filaments, one group consisting of one or more varieties of reinforcing filaments [filaments (A)] and the other group consisting of one or more varieties of matrix filaments [filaments (B)], wherein - the filaments (A) of the first group have an initial modulus of above 600 Cn/tex, preferably of 800 to 25,000 Cn/tex, in particular of 2,000 to 20,000 Cn/tex,  a tenacity of above  60  Cn/tex, preferably of 80 to 220 Cn/tex, in particular of 100 to 200 Cn/tex, and a breaking extension of 0.01 to 20%, preferably of 0.1 to 7.0%, in particular of 1.0 to 5.0%, -the filaments (B) of the second group are thermoplastic filaments which have a melting point which is at least 10 DEG C, preferably 20 to 100 DEG C, in particular 30 to 70 DEG C, below the melting point of the filaments (A), -the filaments (A) have a crimp of 5 to 60%, preferably of 12 to 50%, in particular of 18 to 36%, a three-dimensionally deformable sheet material produced from this hybrid yarn, and a fiber reinforced shaped article produced from the deformable sheet material.  Also described are processes for producing the articles mentioned.
Patent TW-339475-B (TW)
Title: Semiconductor device
Inventor: ADRIANUS WILLEM LUDIKHUIZE
IPC: H01L29/78
Filed: 1996-08-22
Granted: 1998-09-01
Abstract: A osrt of HV-LDMOST semiconductor, including a stronglydoped n-type zone, having the substrate bearing a weak crystal membrane next to the semiconductor surface, including the transistor a leakage zone second conductor-type strong mixture, opposite to the first conductor type, a drift area of weak mixture belonging to the second conductor type, a source area of strong mixture belonging to the second conductor type, the control electrode adjacent to the surface and located on the adjacent surface and belonging to the base area of first conductor type and on the surface, in insulation with it, featuring the leakage area having a strong mixture area belonging to the second conductor and superficially, extending the area to a deeper level than that of the semiconductor body, forming a p-n contact phase and the collapse voltage not lower than that of the BVds of the transistor and in this case, forming a current path, which when on with the transistor, the transistors in the source area and the leakage area separate.
Patent TW-448032-B (TW)
Title: Method for preparing hybridoma for generating human antibody
Inventor: TOMIZUKA KAZUMA
IPC: C07K16/18
Filed: 1996-09-25
Granted: 2001-08-01
Abstract: Herein is provided a method for preparing a hybridoma by immunizing with an antigen a mouse retaining at least one of human #2, #22 and #14 chromosome fragments in at least some of the host cells and fusing a B cell derived from the mouse with a myeloma cell, wherein the mouse is a chimeric mouse or its progeny, said chimeric mouse having been prepared by a method which comprises preparing a microcell containing the human chromosome fragment(s) and transferring the human chromosome fragment(s) into an embryonic stem cell (ES cell) by fusion with the microcell.