Patent SG-11201810177V-A (SG)
Title: Pet-imaging immunomodulators
Inventor: DONNELLY DAVID J
IPC: A61K51/08
Filed: 2017-05-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111111111111111111111111111111111111111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201111 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, A61K 51/08 (2006.01) A61K 101/02 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/US2017/033004 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 17 May 2017 (17.05.2017) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/338,872 19 May 2016 (19.05.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [US/US]; Route 206 and Province Line Road, Princeton, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, New Jersey 08543 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventors: DONNELLY, David J.; c/o Bristol-Myers TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Squibb Company, Route 206 and Province Line Road, KM, ML, MR, NE, SN, TD, TG). Princeton, New Jersey 08543 (US). BOY, Kenneth M.; _ c/o Bristol-Myers Squibb Company, 5 Research Parkway, Declarations under Rule 4.17: Wallingford, Connecticut 06492 (US). ZHANG, Yun- — as to applicant's entitlement to apply for and be granted a hui; c/o Bristol-Myers Squibb Company, 5 Research Park- patent (Rule 4. 17(ii)) = way, Wallingford, Connecticut 06492 (US). KIM, Joony- — as to the applicant's entitlement to claim the priority of the = — oung; c/o Bristol-Myers Squibb Company, Route 206 and earlier application (Rule 4.17(iii)) Province Line Road, Princeton, New Jersey 08543 (US). — of inventorship (Rule 4.17(iv)) — = PENA, Adrienne; c/o Bristol-Myers Squibb Company, Published: Route 206 and Province Line Road, Princeton, New Jersey — with international search report (Art. 21(3)) 08543 (US). = (74) Agent: MINGO, Pamela A. et al.; Bristol-Myers Squibb _ Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). — = Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = = = (54) Title: PET-IMAGING IMMUNOMODULATORS = = = SUV = Fp- = ..,.• t Il 11 11 © N 60 FIG . 1 , IN ,-1 © ei (57) : The invention relates to the synthesis and use of 18 F-labeled millamolecules for imaging various processes within the P1 body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.