Patent SG-11201805422W-A (SG)
Title: Multivalent and multispecific ox40-binding fusion proteins
Inventor: ECKELMAN BRENDAN P
IPC: A61K38/16
Filed: 2017-01-11
Abstract: WO 17 / 12367 3 A3 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/123673 A3 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: A61K 38/16 (2006.01) A61K 45/06 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2017/013070 (22) International Filing Date: 11 January 2017 (11.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/277,027 11 January 2016 (11.01.2016) US (71) Applicant: INHIBRX LP [US/US]; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). (72) Inventors: ECKELMAN, Brendan P.; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). TIMMER, John C.; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). HATA, Chelsie; 11099 N. Torrey Pines Road, Suite 280, La Jolla, Califor- nia 92037 (US). JONES, Kyle S.; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). HUS- SAIN, Abrahim; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). RAZAI, Amir S.; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). BECKLUND, Bryan; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). PAN- DIT, Rajay; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). KAPLAN, Mike; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). RASON, Lucas; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). DEVERAUX, Quinn; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). (74) Agents: KARNAKIS, Jennifer A. et al.; Cooley LLP, 1299 Pennsylvania Avenue, NW, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: MULTIVALENT AND MULTISPECIFIC OX40-BINDING FUSION PROTEINS FIG 5A 111111111111110111011111111111010111110 01110111011110011111011111111111110111111 { OX40 VHH 1) Dimer: — 75kDa 2) Tetramer — 100kDa N : \ 3) Hexamer \"125kDa 2, 4, or 6 (57) : This invention relates generally to molecules that specifically engage OX40, a member of the TNF receptor super- family (TNFRSF). More specifically this invention relates to multivalent and multispecific molecules that bind at least OX40. WO 2017/123673 A3 MIDEDIMOHNIIMMEOMEIIIIMINEIMMOBEIE Declarations under Rule 4.17: before the expiration of the time limit for amending the as to applicant's entitlement to apply for and be granted claims and to be republished in the event of receipt of a patent (Rule 4.17(ii)) amendments (Rule 48.2(h)) Published: (88) Date of publication of the international search report: — with international search report (Art. 21(3)) 24 August 2017