baber/WOPTO huggingface dataset:
Patent CA-3127858-A1 (CA)
Title: Method for measuring the modulation of the activation of a g protein-coupled receptor with gtp analogues
Inventor: ROUX THOMAS
IPC: G01N33/542
Filed: 2020-01-30
Abstract: The invention concerns a method for determining the ability of a molecule to modulate the activation of a G protein-coupled receptor (GPCR), the method comprising the following steps: a) introducing, into a first container: - a membrane preparation bearing one or more GPCR(s) and one or more Galpha protein(s), - a source of non-hydrolysable or slowly hydrolysable GTP labelled by a first member of a pair of RET partners, - a ligand of the alpha sub-unit of a G protein (Galpha protein) labelled by a second member of the pair of RET partners, the ligand being capable of binding with the full Galpha protein bound to the non-hydrolysable or slowly hydrolysable GTP labelled by the first member of a pair of RET partners, - optionally, a GPCR agonist; b) measuring the RET signal emitted in the first container; c) introducing, (i) into a second container, the same reagents as in step a) and the molecule to be tested or, (ii) into the first container, the molecule to be tested; d) measuring the RET signal emitted in the second container or in the first container obtained in step c); e) comparing the signals obtained in steps b) and d), a modulation in the signal obtained in step d) relative to that obtained in step b) indicating that the molecule to be tested is capable of modulating the activation of the GPCR.
Patent CA-3130947-A1 (CA)
Inventor: HEIMBUCH BRIAN K
IPC: A41D13/11
Filed: 2020-04-23
Abstract: A reusable respirator including a mask adapted for covering and conforming to the face around the nose and a mouth of a user, a strap configured to secure the rnask to a face of the user, and a filter cornponent. All components of the respirator are capable of being cleaned, disinfected and sterilized at ternperatures in excess of 50 C. An outer surface of the mask is substantially smooth and wettable for easily disinfecting and is shaped with a pair of outer shield portions for housing particulate air filters. The outer shield portions each include a closeable vent through the outer surface that is adapted to provide a user seal check and direct air flow through the outer surface for filtering by the respective particulate air filter, which is adapted to filter at least 95% of airborne particles.
Patent CA-3131099-A1 (CA)
Inventor: DUNDAR FIELD AYCA
IPC: C08J3/20
Filed: 2020-02-26
Abstract: The invention provides a composition comprising a seaweed extract in an amount of 50-90 % by weight, a water-soluble cellulose derivative in an amount of 10-40 % by weight and water in an amount of 1-20 % by weight, of the total weight of the composition. The invention also provides products, including packaging material, formed from the composition, a method of dissolving, composting and biodegrading the composition or the products, a method of producing the composition and the products, and a method of re-working the composition.
Patent CA-3133072-A1 (CA)
Title: Compositions pharmaceutiques contenant des anticorps anti-lingo-1
Inventor: FERNANDEZ JASON EDWARD
IPC: A61P25/28
Filed: 2020-03-10
Abstract: L'invention concerne des compositions pharmaceutiques contenant des anticorps anti-LINGO-1 ou des fragments de liaison aux LINGO-1 de ceux-ci. Ces compositions pharmaceutiques trouvent une utilité dans le traitement de maladies démyélinisante du SNC, telles que la sclérose en plaques et la névrite optique (par exemple, la névrite optique aiguë).
Patent CA-3133553-A1 (CA)
Inventor: MYUNG SE-HO
IPC: H04L27/36
Filed: 2015-02-23
Abstract: A transmitting apparatus is provided. The transmitting apparatus includes: an encoder configured to generate a low-density parity check (LDPC) codeword by LDPC encoding based on a parity check matrix; an interleaver configured to interleave the LDPC codeword; and a modulator configured to map the interleaved LDPC codeword onto a modulation symbol, wherein the modulator is further configurcd to map a bit included in a predetermined bit group from among a plurality of bit groups constituting the LDPC codeword onto a predetermined bit of the modulation symbol.
Patent CA-3134049-A1 (CA)
Inventor: BHISE NUPURA
IPC: A61K47/12
Filed: 2020-03-19
Abstract: Provided are gastric residence dosage forms comprising: a gastric residence system in a folded configuration; a capsule encapsulating the gastric residence system in a folded configuration; and a coating on the capsule, wherein the gastric residence dosage form is configured to release the gastric residence system in a stomach of a patient, allowing the gastric residence system to assume an open configuration. The coating on the capsule includes a polymer, an anti-tacking agent, and/or a hydration aid.
Patent CA-3135454-A1 (CA)
Inventor: KELLY JEFFERY W
IPC: C07D311/08
Filed: 2020-03-29
Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.
Patent CA-3136772-A1 (CA)
Title: Medicine dispensing system having stair-step dosing indicators
Inventor: HERNANDEZ CALEB
IPC: A61J7/00
Filed: 2020-04-06
Abstract: A medicine dispensing device, configured to contain a liquid medicine to be dispensed by the medicine dispensing device and having a plurality of dosing indicia spaced apart from each other around and in relation to a circumference of a surface of the medicine dispensing device, each dosing indicia being of a different height relative to a reference level and corresponding to different dose of the liquid medicine.
Patent CA-3137515-A1 (CA)
Title: Cross product enhanced subband block based harmonic transposition
Inventor: VILLEMOES LARS
IPC: G10L21/04
Filed: 2011-09-05
Abstract: A system for generating a time stretched and/or frequency transposed signal from an audio input signal includes an analysis filter bank configured to derive a number of analysis subband signals from the audio input signal. The analysis subband signals comprise complex- valued analysis samples. A subband processing unit generates a synthesis subband signal from the analysis subband signals. The subband processing unit comprises a block extractor and a nonlinear frame processing unit. For each of the analysis subband signals the block extractor i) forms a frame of L input samples extracted from the complex-valued analysis samples; and ii) applies a block hop size of h samples to the complex-valued analysis samples, prior to forming a subsequent frame of input samples. The nonlinear frame processing unit generates a frame of processed samples by determining a phase and magnitude for each processed sample of the frame. For at least one processed sample: i) the phase of the processed sample is based on the respective phases of the corresponding input sample in the frames of input samples; and ii) the magnitude of the processed sample is based on the magnitude of the corresponding input sample in the frames of input samples. A windowing unit applies window function to the frame of processed samples. Overlapped and added window samples of a plurality of window functions, when weighted by complex weights and shifted with a hop size, form a substantially constant sequence. An overlap and add unit determines the synthesis subband signal by overlapping and adding the samples of a sequence of frames of windowed processed samples. A synthesis filter bank generates the time stretched and/or frequency transposed signal from at least the synthesis subband signal output by the subband processing unit.
Patent CA-3140319-A1 (CA)
Inventor: DELLA RAGIONE RICCARDO
IPC: A61M1/36
Filed: 2020-05-13
Abstract: L'invention concerne un procédé de fabrication d'une composition comprenant du plasma riche en plaquettes, un appareil (100) de centrifugation utilisable pour la mise en oeuvre du procédé, un kit à usage unique (10) qui, lorsqu'il est combiné à un appareil, permet d'obtenir un dispositif (1) pour fabriquer une composition comprenant du plasma riche en plaquettes.
Patent CA-3141676-A1 (CA)
Title: Ice shield for tower mounted equipment
Inventor: LARSEN ERIK
IPC: H01Q1/00
Filed: 2020-06-02
Abstract: A tower (1) having equipment (3) mounted thereon is disclosed. The tower (1) has an ice shield assembly (2) for protection of the equipment (3) against falling ice mounted thereon. The ice shield assembly (2) comprises a tower fixture arrangement (5) being secured to the tower (1) and an ice shield (4) connected 5 to the tower fixture arrangement (5) via a hinge (6). The ice shield (4) is configured for vertically overlapping the horizontal extends of the equipment (3). The ice shield assembly (2) further comprises at least one spring element (7), e.g. in the form of a curved rod, connected at one end to the ice shield (4) and at an opposite end to the tower (1), the at least one spring element (7) 10 being configured to allow the ice shield (4) to pivot relative to the tower (1) at the hinge (6) in order to ensure a gradual transfer of energy from falling ice, which collides with the ice shield (4).
Patent CA-3141723-A1 (CA)
Inventor: SAVAGE PAUL B
IPC: A61K45/06
Filed: 2020-05-22
Abstract: La présente invention concerne des compositions et des procédés de régénération de tissu et/ou de prévention de perte de tissu par stimulation de cellules souches. Un procédé selon l'invention consiste à fournir une composition de traitement qui contient un ou plusieurs composés CSA et un support, à appliquer la composition de traitement sur une région tissulaire ciblée d'un sujet ; la composition de traitement stimulant la régénération tissulaire et/ou assurant la prévention de la dégradation tissulaire au niveau de la région ciblée du sujet.
Patent CA-3141792-A1 (CA)
Title: Set of stick-shaped filters made of cardboard, preform for the manufacture thereof and packaging thereof
Inventor: PARTOUCHE OLIVIER
IPC: A24C5/40
Filed: 2020-06-03
Abstract: The present invention relates in particular to a set (2) of filters (10) made of cardboard or cellulosic material. In particular, the set is characterised by the fact that it is in the shape of a generally cylindrical stick which is made up of a plurality of individual filters (10), each formed of a winding on itself of a side made of cardboard or cellulosic material, said filters (10) being arranged in extension of one another and being partially connected in pairs by connecting means (3), such that it is possible to separate at least one filter (10) from the stick by removing or severing the connecting means (3).
Patent CA-3145172-A1 (CA)
Title: Forming and processing method
Inventor: IHARA TOMOAKI
IPC: B21D28/02
Filed: 2022-01-10
Abstract: Only a punched end is locally heated while a current value of a heating electrode is stabilized during heating. A forming and processing method includes punching a steel plate, and disposing a heating coil so as to face an end face of a punched end punched in the punching in a non-contact manner along the end face of the punched end and applying a current to the heating coil to generate an induced electromotive force in the steel plate, thereby heating the end face.
Patent CA-3145229-A1 (CA)
Inventor: LECHARPENTIER DENIS
IPC: H01R13/53
Filed: 2020-07-10
Abstract: The invention relates to a terminal device (1) for a cable with mineral insulation, comprising a metal bushing (3) of which one end is intended to be secured to the end of the cable and a ceramic insulating element (4). The invention also consists in that said ceramic insulating element consists of a cylinder (4) accommodated in the bushing (3), with one end projecting from said bushing (3) and its opposite end, which has a bore (41), accommodated in the bushing (3), said end of the cylinder (4) that is accommodated in the bushing (3) having a tapered shape.
Patent CA-3145625-A1 (CA)
Inventor: SCHMIDT HOWARD K
IPC: E21B33/13
Filed: 2022-01-11
Abstract: A method for manipulating hydraulic fracture geometry. In one embodiment, the method comprises injecting a fracturing fluid into a well to generate one or more hydraulic fractures in a subsurface rock fomiation and then substantially draining any fluids from the one or more hydraulic fractures. The method may further comprise injecting a hydrophilic polymer and one or more crosslinking agents into the well to subsequently fonn low-density hydrogels which may then screen out only each tip of the one or more hydraulic fractures. A working fluid may then be injected into the well to increase fracture width of the one or more hydraulic fractures without substantially increasing fracture length. In an alternative embodiment, the hydrophilic polymer may be fully crosslinked by the one or more crosslinking agents and injected as pre-fomied particle gels (PPGs) which may also screen out only each tip of the one or more hydraulic fractures.
Patent CA-3146263-A1 (CA)
Title: Prophylaxie pre-exposition du vih
Inventor: GARCIA LERMA JOSE GERARDO
IPC: A61K31/506
Filed: 2020-01-27
Abstract: La présente invention concerne l'utilisation d'un inhibiteur nucléosidique de la transcriptase inverse, d'un inhibiteur nucléotidique de la transcriptase inverse et d'un inhibiteur de l'intégrase après exposition à une infection potentielle par le virus de l'immunodéficience humaine (VIH) pour protéger le sujet contre l'infection par le VIH. Dans certains modes de réalisation, une quantité prophylactiquement efficace d'emtricitabine (FTC), une quantité prophylactiquement efficace de ténofovir ou d'un promédicament de ténofovir, tel que le ténofovir alafénamide (TAF) ou le fumarate de ténofovir disproxil (TDF), une quantité prophylactiquement efficace de l'inhibiteur d'intégrase elvitégravir (EVG), et éventuellement du cobistat (COBI) sont utilisés pour inhiber ou prévenir une infection par le VIH, ces agents étant administrés uniquement après une exposition potentielle au VIH. Dans des exemples spécifiques non limitatifs, une seule dose des agents viraux antirétroviraux est administrée à un sujet avant l'exposition.
Patent CA-3147138-A1 (CA)
Title: High precision greenhouse seed and seedling treatment
Inventor: RICKARD JAMIE
IPC: A01G9/08
Filed: 2020-08-14
Abstract: The present invention relates to an apparatus and a method for treating and transplanting plant propagation materials into a cultivation medium, comprising: a. providing a plurality of plant-receiving cavities in the cultivation medium; b. providing the plant propagation materials (K) in a reservoir (10); c. removing from the reservoir container and separating out plant propagation materials, and d. orienting the separated-out plant propagation materials in a position upwardly of the cavity, and e. releasing the plant propagation material from the orientation position into the associated plant-receiving cavity, and f. selectively applying a dressing composition aliquot to a surface of the plant propagation material while it is moving towards the plant-receiving cavity.
Patent CA-3149284-A1 (CA)
Inventor: CAMPBELL PATRICK
IPC: A61L31/18
Filed: 2010-12-15
Abstract: The present invention relates to a water-degradable hydrogel implant obtainable by preparing a hydrogel comprising a covalently attached radiopaque agent. The hydrogel is formed from a first and a second precursor comprising a plurality of first and second functional groups respectively, with the first functional groups forming covalent bonds with the second functional groups to form the hydrogel. The first precursor comprises the radiopaque agent and a branched polyethylene glycol with at least four arms.  The present invention also relates to use of a hydrogel spacer comprising a hyaluronic acid and an attached radiopaque agent for radiation therapy.
Patent CA-3149633-A1 (CA)
Title: Compositions de trofinetide
Inventor: BLOWER CLIVE
IPC: A61K31/197
Filed: 2020-08-03
Abstract: La présente invention concerne des composés de formule (I), des stéréo-isomères, des composés secondaires et des compositions pharmaceutiques de ceux-ci, et des procédés de fabrication de tels composés à l'aide de réactifs de silylation et la production de compositions et de produits fabriqués à l'aide de tels procédés. Plus particulièrement, l'invention concerne la fabrication de trofinétide et de produits secondaires, des compositions et des produits contenant de tels composés, pour des utilisations pharmaceutiques pour traiter des troubles neurodégénératifs ou neurodéveloppementaux.
Patent CA-3152608-A1 (CA)
Inventor: SEGAL YARON
IPC: A61N2/04
Filed: 2020-11-18
Abstract: L'invention concerne un appareil de traitement pouvant être porté sur le corps afin de traiter des troubles et des affections neurologiques du système nerveux central par l'application, à celui-ci, de champs électromagnétiques. L'appareil comprend une partie de montage de bobine et une partie se montant sur le corps, la partie de montage de bobine étant montée de manière amovible sur la partie se montant sur le corps, et un système comprenant au moins une base de données stockant des informations relatives à des protocoles de traitement, un serveur communiquant avec l'au moins une base de données, et un appareil de traitement pouvant être porté sur le corps et communiquant avec le serveur, l'appareil de traitement pouvant être porté sur le corps comprenant une partie de montage de bobine et une partie se montant sur le corps, la partie de montage de bobine étant montée de façon amovible sur la partie se montant sur le corps.
Patent CA-3153149-A1 (CA)
Title: Fuel injector
Inventor: ROGERS RICHARD A
IPC: F23R3/14
Filed: 2020-09-17
Abstract: A fuel injector (600) for a combustor of a gas turbine engine (100) is disclosed herein. The fuel injector (600) includes a fuel stem assembly (620) for receiving and distributing fuel and an injector head (630) receiving fuel from the fuel stem assembly (620). The injector head (630) includes an injector body (640), swirler vanes (660), a pilot assembly (700), passages (666, 667, 726, 745, 746), and fuel galleries (646, 647, 736). The pilot assembly (700) includes a pilot tube (746) and can include pilot struts (720). The swirler vanes (660) include passages (666) to transport the pilot fuel from the fuel stem assembly (620) to the pilot tube (746).
Patent CA-3155179-A1 (CA)
Inventor: BAJAJ DEVENDRA NARAYANDAS
IPC: C08K7/18
Filed: 2020-10-09
Abstract: Pièces de boîtier pour dispositifs électroniques portables et procédés de moulage de telles pièces de boîtier pour dispositifs électroniques portables. De telles pièces de boîtier comprennent : un élément de boîtier comprenant des particules de céramique dans une matrice polymère, les particules de céramique constituant de 50 % à 90 % en volume de l'élément de boîtier, et la matrice polymère constituant de 10 % à 50 % en volume de l'élément de boîtier ; les particules de céramique ont une Dv50 de 50 nanomètres à 100 micromètres ; les particules de céramique sont sensiblement exemptes d'agglomération ; l'élément de boîtier a une densité relative supérieure à 90 % ; et l'élément de boîtier est configuré pour recouvrir une partie d'un dispositif électronique portable. Les présents procédés de moulage de telles pièces de boîtier consistant : à disposer des particules cur-enveloppe en polymère-céramique dans une partie de travail d'une cavité dans un moule, chacune des particules cur-enveloppe comprenant un cur en céramique comprenant une particule de céramique, et une enveloppe polymère autour du cur, l'enveloppe comprenant un polymère, les curs en céramique constituant de 50 % à 90 % en volume de la poudre, et les enveloppes polymères constituant de 10 % à 50 % en volume de la poudre ; à chauffer le moule à une première température supérieure à une température de fusion (Tm) du premier polymère ; à soumettre la poudre dans le moule à une première pression tout en maintenant la température du moule à la première température ou au-dessus pour définir un élément de boîtier dans lequel les particules de céramique sont sensiblement exemptes d'agglomération ; à refroidir l'élément de boîtier à une température inférieure à la température Tg ou Tm du premier polymère ; et à démouler l'élément de boîtier. Dans de telles pièces de boîtier et de tels procédés, les particules de céramique comprennent de l'Al2O3, du Fe3O4, du Fe2O3, du ZnO, du ZrO2, SiO2 et/ou une combinaison d'au moins deux de ces céramiques ; et le polymère comprend du PPE, du PPS, des copolymères de PC, du PEI, des copolymères de PEI, du PPSU, du PAES, du PES, de la PAEK, du PBT, du PP, du PE, du PI semi-cristallin ou du polyamide semi-cristallin.
Patent CA-3158606-A1 (CA)
Title: Procede et dispositif pour separer des blocs de bois scies en un rendement principal et des deblais connexes
Inventor: RENDLER MARTIN
IPC: B27B31/00
Filed: 2020-11-13
Abstract: Dans un procédé pour séparer un bloc de bois scié obtenu d'un tronc en un rendement principal et des déblais connexes à l'aide d'un convoyeur séparateur, le bloc de bois scié est convoyé dans une direction longitudinale par l'intermédiaire d'un dispositif de transport sous-jacent du convoyeur séparateur. Tandis que le rendement principal en une ou plusieurs pièces est supporté par le dispositif de transport, une ou plusieurs plaques connexes sont séparées transversalement à la direction de convoyage à l'aide d'une force gravitationnelle et/ou de forces externes, ainsi des éléments de retenue latéraux sont brièvement ouverts pour une libération. Afin de pouvoir traiter des troncs avec une plage de diamètres aussi large que possible, les plaques connexes situées sur des côtés opposés du bloc de bois scié sont séparées en deux étapes de séparation consécutives, les éléments de retenue latéraux du convoyeur séparateur étant ouverts d'un côté sur un côté de libération respectif dans les étapes de séparation consécutives.
Patent CA-3159840-A1 (CA)
Inventor: ETTORI MAXIME
IPC: A61M37/00
Filed: 2019-12-20
Abstract: L'invention concerne des dispositifs d'administration transdermique de médicament, tels qu'un timbre de réseau de micro-aiguilles, destinés à être placés sur la peau pour l'administration transdermique d'un médicament. Le dispositif d'administration transdermique de médicament pour l'administration d'un agent bioactif à travers la peau d'un mammifère comprend un réseau de micro-aiguilles et un moyen pour actionner les micro-aiguilles, le moyen d'actionnement actionnant les micro-aiguilles séparément.
Patent CA-3162299-A1 (CA)
Title: Device for orienting a load in two orthogonal axes of rotation
Inventor: BLAIS THIERRY
IPC: H01Q3/06
Filed: 2020-12-08
Abstract: The invention relates to a device (100) for orienting a load (10) intended to orient said load about a main axis X and a secondary axis Y, comprising: - a first shaft, called transmission shaft (11), intended to support the load and configured to be rotated about the main axis and the secondary axis; - a second shaft (21) configured to be rotated about the main axis X; - a third shaft (31) configured to be rotated about a third axis of rotation (35), in the same direction as the main axis; - a first connection component (40) between the transmission shaft (11) and the second shaft (21), configured to prevent relative movements between the transmission shaft and the second shaft in, on the one hand, a degree of rotational freedom about the main axis X and, on the other hand, three degrees of translational freedom; - a second connection component (50) between the transmission shaft and the third shaft and configured to allow relative movements between the transmission shaft and the third shaft in, on the one hand, a degree of translational freedom along the third axis of rotation and, on the other hand, three degrees of rotational freedom, wherein the second connection component, the transmission shaft and the third shaft form an eccentric kinematic connection.