Patent SG-11201901726Q-A (SG)
Title: Method and system for panel characterizations
Inventor: ALMONACID DANIEL
IPC: A61B5/05
Filed: 2017-09-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) -., (19) World Intellectual Property 111111411 01E101011M 3E1 0 10111111011100111011111001111011110111111 Organization . International Bureau (10) International Publication Number (43) International Publication Date ......'\"' WO 2018/053443 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: RICHMAN, Jessica; 360 Langton Street, #301, San Fran- A61B 5/05 (2006.01) G06F 19/00 (2018.01) cisco, CA 94103 (US). APTE, Zachary; 360 Langton A61B 1/00 (2006.01) Street, #301, San Francisco, CA 94103 (US). BIK, Elisa- (21) International Application Number: beth; 360 Langton Street, #301, San Francisco, CA 94103 PCT/US2017/052098 (US). GODDARD, Audrey; 360 Langton Street, #301, San Francisco, CA 94103 (US). (22) International Filing Date: (74) Agent: SCHOX, Jeffrey; 500 3rd Street, Suite 215, San 18 September 2017 (18.09.2017) Francisco, CA 94107 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/395,939 16 September 2016 (16.09.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 15/606,743 26 May 2017 (26.05.2017) US DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/520,058 15 June 2017 (15.06.2017) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/525,379 27 June 2017 (27.06.2017) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: UBIOME, INC. [US/US]; 360 Langton Street, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, #301, San Francisco, CA 94103 (US). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ (72) Inventors: ALMONACID, Daniel; 360 Langton Street, — #301, San Francisco, CA 94103 (US). KRAAL, Laurens; (84) Designated States (unless otherwise indicated, for every = 360 Langton Street, #301, San Francisco, CA 94103 (US). kind of regional protection available): ARIPO (BW, GH, OSSANDON, Francisco; 360 Langton Street, #301, San GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, =_ Francisco, CA 94103 (US). CARDENAS, Juan, Pablo; UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 360 Langton Street, #301, San Francisco, CA 94103 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: METHOD AND SYSTEM FOR PANEL CHARACTERIZATIONS = = loo (57) : Embodiments of a system and method for characterizing a = \-/-\ panel of conditions associated with a set of taxa related to microorganisms can include a taxonomic database including reference microbiome features o generating a taxonomic database associated with markers for a plurality of taxa S110 for the set of taxa associated with the panel of conditions; a handling operable to including biological from the handling collect a container material a user, = — + i = _ — = generating a microbiome dataset (e g., a microorganism sequence dataset ► including microorganism sequences, etc.) for a user based on a biological sample collected from the user S120 collecting a supplementary dataset informative of the panel of conditions S125 system comprising a sequencer system operable to determine a microorgan- ism sequence dataset; and a panel characterization system operable to: de- termine user microbiome features for the set of taxa for the user based on t the microorganism sequence dataset, generate a comparison between the user = = 1' 1 validating the characterization microbiome features and the reference microbiome features, and determine = — = performing a characterization process process S150 4 a panel characterization for the panel of conditions for the user based on the comparison; and a treatment system operable to promote a therapy for a con- — = — performing a characterization for at least one of microbiome composition, microbiome functional diversity, and/or associated conditions, based on the taxonomic database and the microbiome datasets S130 ___ _ ...j determining a probiotics-related characterization tg,„nlbea rosbe,do moue dataset and the taxonomic database) S145 dition of the panel of conditions based on the panel characterization. 11 71' 71' en © \ .... GC 11 © N , promoting a therapy for characterization FIGURE i M he user based on the process LLIQ 1A C [Continued on next page] WO 2018/053443 Al MIDEDIMOMMIONERIONINIMOIMIDOMEHOE# EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of