Patent SG-11201806429P-A (SG)
Title: Substituted piperidine compound and use thereof
Inventor: FUJIMOTO TATSUHIKO
IPC: C07D211/36
Filed: 2017-02-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 10 August 2017 (10.08.2017) WIPO I PCT (10) International Publication Number WO 2017/135306 Al 11111111111111011101010111110101111101111111101111011011111011111111111111110111111 (51) International Patent Classification: CO7D 211/36 (2006.01) A61P 3/04 (2006.01) A61K 31/435 (2006.01) (21) International Application Number: PCT/JP2017/003610 (22) International Filing Date: 1 February 2017 (01.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016-019834 4 February 2016 (04.02.2016) JP (71) Applicant: TAKEDA PHARMACEUTICAL COM- PANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: FUJIMOTO Tatsuhiko; c/o TAKEDA PHAR- MACEUTICAL COMPANY LIMITED, 26-1, Muraoka- Higashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). RIKIMARU Kentaro; c/o TAKEDA PHARMACEUTIC- AL COMPANY LIMITED, 26-1, Muraoka-Higashi 2- chome, Fujisawa-shi, Kanagawa, 2510012 (JP). FUKUDA Koichiro; c/o TAKEDA PHARMACEUTICAL COM- PANY LIMITED, 26-1, Muraoka-Higashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). SUGIMOTO Hiromichi; c/o TAKEDA PHARMACEUTICAL COM- PANY LIMITED, 8-2, Marunouchi 1-chome, Chiyoda-ku, Tokyo, 1000005 (JP). MATSUMOTO Takahiro; 19-17, Shonandai 5-chome, Fujisawa-shi, Kanagawa, 2520804 (JP). TOKUNAGA Norihito; c/o TAKEDA PHARMA- CEUTICAL COMPANY LIMITED, 26-1, Muraoka-Hi- gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). HIROZANE Mariko; c/o TAKEDA PHARMACEUTIC- AL COMPANY LIMITED, 26-1, Muraoka-Higashi 2- chome, Fujisawa-shi, Kanagawa, 2510012 (JP). (74) Agent: TAKASHIMA Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- ku, Osaka-shi, Osaka, 5410044 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, [Continued on next page] (54) Title: SUBSTITUTED PIPERIDINE COMPOUND AND USE THEREOF (57) : Provided is a substituted piperidine com- pound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each sym- bol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as HN R 3 a prophylactic or therapeutic agent for narcolepsy. W O 20 17 / 135 306 Al WO 2017/135306 Al MIDEDIMOMOIDEIRMEM30111410111001101MOVOIMIE RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))