Patent SG-11201807770R-A (SG)
Title: Sequence arrangements and sequences for neoepitope presentation
Inventor: NIAZI KAYVAN
IPC: G16B20/20
Filed: 2017-03-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011110111010101111101011111001111111111111111111110111110111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/222619 A2 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Not classified KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/US2017/023894 Published: — without international search report and to be republished (22) International Filing Date: upon receipt of that report (Rule 48.2(g)) 23 March 2017 (23.03.2017) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/312,974 24 March 2016 (24.03.2016) US 62/313,621 25 March 2016 (25.03.2016) US 62/314,366 28 March 2016 (28.03.2016) US (71) Applicants: NANTCELL, INC. [US/US]; 9920 Jeffer- son Boulevard, Culver City, California 90232 (US). NANT HOLDINGS IP, LLC [US/US]; 9920 Jefferson Boulevard, Culver City, California 90232 (US). (72) Inventors: NIAZI, Kayvan; 9920 Jefferson Boulevard, Culver City, California 90232 (US). NGUYEN, An- _ = drew; 9920 Jefferson Boulevard, Culver City, California 90232 (US). RABIZADEH, Shahrooz; 9920 Jefferson Boulevard, Culver City, California 90232 (US). SOON- =_ SHIONG, Patrick; 9920 Jefferson Boulevard, Culver City, California 90232 (US). BENZ, Stephen Charles; 436 Park = Way, Santa Cruz, California 95062 (US). Agent: FESSENMAIER, Martin et al.; Fish & Tsang, LLP, 2603 Main Street, Suite 1000, Irvine, California 92614 = (74) (US). = (81) Designated States (unless otherwise indicated, for every = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = — SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, — ei 1-1 ei ei ei N (54) Title: SEQUENCE ARRANGEMENTS AND SEQUENCES FOR NEOEPITOPE PRESENTATION 1-1 0 (57) : Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate a ei recombinant polytope that is optimized for proper trafficking and processing. In preferred methods, the polytope is encoded in a viral 0 expression system that is used as a therapeutic agent.