baber/WOPTO huggingface dataset:
Patent CR-20190489-A (CR)
Title: Compounds that inhibit mcl-1 protein
Inventor: KOHN TODD J
IPC: C07D498/08
Filed: 2018-03-28
Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (I), or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
Patent EC-SP055594-A (EC)
Title: Nuevos derivados de 2-piridiletilbenzamida
Inventor: MANSFIELD DAREN JAMES
IPC: A01N43/40
Filed: 2005-02-10
Abstract: Compuesto de fórmula general (I) 	en la que-p es un número entero igual a 1, 2, 3 ó 4;-q es un número entero igual a 1, 2, 3, 4 ó 5;-cada sustituyente X se elige, independientemente del resto, de halógeno, alquilo o haloalquilo, siendo al menos uno de los sustituyentes un haloalquilo;-cada sustituyente Y se elige, independientemente del resto, de halógeno, alquilo, alquenilo, alquinilo, haloalquilo, alcoxi, amino, fenoxi, alquiltio, dialquilamino, acilo, ciano, éster, hidroxi, aminoalquilo, bencilo, haloalcoxi, halosulfonilo, halotioalquilo, alcoxialquenilo, alquilsulfonamida, nitro, alquilsulfonilo, fenilsulfonilo o bencilsulfonilo;	y los N-óxidos de 2-piridina de los mismos.	con la excepción de N-{2-[3-cloro-5-(trifluorometil)-2-piridinil]etil}-2,6-diclorobenzamida.	Procedimiento para preparar el compuesto de fórmula general (I).	Composición fungicida que comprende el compuesto de fórmula general (I).	Procedimiento para tratar enfermedades fitopatógenas.
Patent EC-SP077894-A (EC)
Title: Antagonistas de npy, preparación y usos
Inventor: SERRADEIL-LE GAL CLAUDINE
IPC: C07D417/12
Filed: 2007-11-13
Abstract: La presente invención se refiere a compuestos novedosos, su preparación y sus usos, usos terapéuticos en particular. Se refiere más específicamente a los compuestos derivados que tienen al menos dos ciclos aromáticos, su preparación y sus usos, en particular en el área de la salud humana o animal. Estos compuestos tienen una afinidad para los receptores biológicos del neuropéptido Y, NPY, presentes en los sistemas nerviosos centrales y periféricos. Los compuestos de la invención son preferiblemente antagonistas de NPY, y más en particular antagonistas del subtipo NPY Y1, y por lo tanto se pueden utilizar para el tratamiento, terapéutico o profiláctico, de cualquier trastorno el cual implica al NPY. La presente invención también se refiere a las composiciones farmacéuticas que contienen dichos compuestos, su preparación y sus usos, así como a los métodos de tratamiento que utilizan dichos compuestos.
Patent EC-SP961743-A (EC)
Title: Combinaciones de antagonistas de nmda del subtipo nr2b y agonistas de dopamina
Inventor: CHENARD BERTRAND L
IPC: A61K38/00
Filed: 1996-05-09
Abstract: Esta invención se refiere al tratamiento de la enfermedad de parkinsonismo (también denominado parkinsonismo). Especificamente, esta invención se refiere al tratamiento de mamíferos que sufren parkinsonismo que comprende la administración a dicho mamífero de una cantidad sinérgica de un antagonista selectivo del N-metil-D-aspartato (en lo sucesivo NMDA) del cerebro anterior y un compuesto capaz de aumentar la retroalimentación excitadora del núcleo lateral ventral del tálamo al cortex, de forma que se restaura el equilibrio de la retroalimentación excitadora del núcleo ventral lateral del tálamo al cortex en dicho mamífero que sufre la enfermedad de Parkinson.
Patent EC-SP972152-A (EC)
Title: Compuestos que tienen actividad farmacologica, procedimientos para su preparacion, composiciones que los contienen y su uso en el tratamiento del sistema nervioso central
Inventor: BROMIDGE STEVEN MARK
IPC: A61K9/20
Filed: 1997-06-18
Abstract: El invento se refiere a compuestos heterocíclicos que tienen actividad farmacológica a procedimientos para su preparación a composiciones que los contienen y a su uso en el tratamiento de trastornos del sistema nervioso central, tales como ansiedad.
Patent EC-SP993173-A (EC)
Title: Composiciones que contienen acidos difosfonicos
Inventor: GABEL ROLF-DIETER
IPC: A61K33/42
Filed: 1999-10-08
Abstract: La invención se refiere a una forma sólida de administración framacéutica que contiene como sustancia activa un ácido difosfónico o una sal fisiológicamente compatible del mismo, en la que la sustancia activa está presente en forma granulada, opcionalmente junto con adyuvantes farmacéuticos, en la fase interna y la fase externa contiene un lubricante en forma de menos de 5% en peso de ácido esteárico, en relación al peso total de la forma de administración.
Patent FR-1604305-A (FR)
Title: Liquid treatment unit - in which proportional dosing pump has exchange reservoir for treatment solution
IPC: B01J4/02
Filed: 1968-12-24
Granted: 1971-10-11
Abstract: Treatment solution is dosed into a pipe in proportion to the rate of flow of water through the pipes. The unit comprises a flow-meter which fits in the pipe line and a housing for pump and solution reservoir which can be turned with respect to the flow-meter so that the pump and reservoir are upright no matter what the disposition of the pipeline. The reservoir can be made easily removable, pref. expendable by fitting a refill reservoir; this improves pump cleanliness and reliability, particularly when handling solutions of silicates and polyphosphates.
Patent GB-1050661-A (GB)
IPC: B63H23/20
Abstract: 1,050,661. Power plant. COMPAGNIE ELECTOR-MECANIQUE. May 15, 1964. No. 20277/64. Heading F1Q. In a marine propulsion installation at least one gas turbine 6 and a steam turbine 21, operating in a combined cycle, provide the forward drive, at least one gas turbine 11 and a steam turbine 23 provide the reverse drive, a post-combustion chamber 19 is arranged upstream of the steam generator 20 and the steam circuit is used during the forward drive for placing the reverse drive turbine under vacuum. The gas generator consists of a compressor 1 having adjustable bladings 2, starter motor 3, combustion chamber 5 and gas turbine 4. A post-combustion burner 29 may be provided. Turbine 6, which has completely closable bladings 7, drives shaft 10 through pinion 8 and tooth wheel 9. Turbine exhaust gases are either fed through a duct 18 to the ship's chimney or through post-combustion chamber 19 to generator 20. Steam is supplied through valve 30 to turbine 21 which drives wheel 9 through pinion 22. Reverse-motion turbine 23 is directly coupled to pinion 22 and during reverse-motion is fed with steam through a valve 31 and pipe 25. The reversemotion gas turbine 11 is normally kept at no-load condition by connecting its discharge through valve 33 and duct 12 to steam condensor 13 and feeding steam through valve 32 to all its valves and fluidtight boxes. For reverse-motion valves 32, 33 are closed and valves 15, 16 opened to deliver exhaust gas from turbine 4. Turbine 11 is restored to no-load conditions by feeding steam through duct 14 to ejector 17 and then restoring connection with condenser 13. The reverse-motion turbine 23 is put in the no-load condition during forward motion by means of pipe 24. In another embodiment a reverse-motion gas turbine 27, Fig. 2 (not shown) is connected to pinion 8 through a releasable coupling 28. In modifications chamber 19 and boiler 20 may be replaced by a boiler with built-in burner, the combined gas-steam cycle may be used for the reverse-motion turbines and the gas generator may consist of one or more free-piston gas generators.
Patent GB-1084243-A (GB)
IPC: B65D5/42
Abstract: 1,084,243. Boxes. NEW MERTON BOARD MILLS Ltd. May 11, 1964 [May 13, 1963], No. 18857/63. Heading B8P. A collapsible cardboard box has first and second pairs of opposite sides extending from a bottom panel, the second pair being double walled and the first pair each having a top member with two flaps which are tucked into the double walls when the top members are positioned parallel to the bottom. The wall panels 2 have extensions 4 with interlocking tongues 5 and slits 6 which interengage to form the outer panels of the double walls with panels 3 forming the inner panels. Hinged to each wall 2 is a member 7 with end flaps 8 which are folded such that the member 7 is parallel to the bottom 1 and the flaps 8 are enclosed between the panels 3, 4. Top extensions 9 are folded about a weakened line 11 so that end tab portions 10 bear on the members 7, the members 7, 9 forming shoulders to facilitate stacking.
Patent GB-1095578-A (GB)
IPC: F02F1/42
Abstract: 1,095,578. Cylinders. MOTOREN-WERKE MANNHEIM A. G. July 29, 1965, No.32555/65. Heading F1B. An inlet duct 1 leads from an outwardly facing lateral face 2 of a cylinder head to first and second inlet ports 3 and 5. The ports are provided with masks 20, 21, which may be crescent or frusto-sector shaped, Figs.9 and 10 (not shown). The duct is substantially rectangular except in the region of the inlet valve guides, Figs. 3-5 (not shown). The masks are omitted in a modification, Figs.1, 2 (not shown). The range of values which the angles #, y, # can take is disclosed as well as preferred dimensions for the masks.
Patent GB-1101182-A (GB)
Abstract: 1,101,182. Dividing circuits. BABCOCK & WILCOX Ltd. 29 July, 1964 [29 July, 1963], No. 40198/67. Divided out of 1,101,181. Heading G4G. [Also in Division G1] The ratio of an A.C. to a D.C. signal is derived by feeding both signals to a device presenting an A.C. resistance inversely proportional to the D.C. flowing through it. In a flame monitoring circuit a photo-conductive cell 41, Fig. 2, receiving radiation from the flame passes a D.C., corresponding to average flame brightness, with a superimposed A.C. corresponding to flame flicker and the quality of the flame is assessed by determining the ratio of the A.C. to the D.C. The D.C. is extracted from the cell current by a filter 45, 51 and passed through a Mullard type OA21 silicon diode whose A.C. resistance is inversely proportional to this D.C. The A.C. signal in the cell current passes through a capacitor 52 and is applied via a transistor to the diode 47. The voltage developed across diode 47 is proportional to the ratio of the A.C. signal to the D.C. signal and is applied to indicating, control or alarm means. The circuit includes a further diode 44 which has similar characteristics to 47 and compensates as claimed in Specification 1,101,181 for the increased inertia of cell 41 at low levels of illumination.
Patent GB-1115998-A (GB)
IPC: H03M1/50
Abstract: 1,115,998. Analogue-to-digital converters. COMPAGNIE DES COMPTEURS. 22 Sept., 1965 [28 Sept., 1964], No. 40472/65. Heading G4H. In an analogue-to-digital converter of the kind which produces a timed pulse representing the input analogue and another timed pulse representing the zero value, there are two bi-stables one of which is set by the input value pulse or the other, by the zero pulse, whichever comes first, the bi-stable set preventing the other becoming set. The signals are also each connected to reset the other bi-stable so that the bi-stable that becomes set opens a corresponding gate allowing pulses to pass to a counter. In the form of Fig. 2, temperature is measured by a resistive transducer 7 connected in a bridge 5. The resistor 7 is balanced by variable resistor 8 driven through its whole range by motor 13. A switch 19 gives a pulse Z at the moment resistor 8 corresponds to a temperature of 0‹ C. If the temperature is positive the bridge balances before the zero pulse Z occurs. Detector 6 produces the balance pulse M which sets bi-stable 12 to open gate 22 to allow pulses from alternator 25 and pulse shaper 26 to pass to counter 2. The zero pulse Z resets bi-stable 12 and the counter 2 indicates the value. A bi-stable 35 is set by whichever of the bi-stables 11 and 12 is first set to indicate the sign of the value digitized. In another form the position of a shaft is sensed by a rotating disc having a photo-cell to detect the needle. This corresponds to the timed pulse M. The zero pulse Z is produced as before by a switch.
Patent GB-1143637-A (GB)
IPC: C01B13/28
Abstract: 1,143,637. Inorganic oxides. FARBENFABRIKEN BAYER A.G. 15 March, 1966 [24 March, 1965], No. 11335/66. Heading C1A. [Also in Division H5] Thermal decomposition of inorganic halides with oxygen and/or steam containing gases, is carried out by heating a gas which is inert in the reaction in a blown high-pressure high voltage arc, and mixing this gas with the reactants to maintain a theoretical mixing temperature above 800 C. The inert gas which may be N 2 , Cl 2 , a noble gas or CO 2  is heated to between 2,00 and 10,000K and passes tangentially into the arc at a velocity of at least 40 m/sec. and the arc may be rotated by a magnetic field. Additives which form nuclei or free radicals may be added to the reacting compounds or to the inert gas. The halides may be of iron, aluminium, silicon, titanium, zirconium or magnesium.
Patent GB-1225453-A (GB)
IPC: G03B13/36
Filed: 1969-11-05
Abstract: 1,225,453. Focusing cameras. BELL AND HOWELL CO. Nov. 5, 1969 [Nov. 29, 1968], No. 54256/69. Heading G2A. A camera in which the focus is adjusted according to the attitude taken up by a freely hanging pendulous member when the camera is pointed at the front of an object to be photographed has a cam means separate from said member but which is oriented in response to the position of said member. The focus can also be adjusted manually, independently of the orientation of the pendulous member. As shown, the objective lens 28 of the camera is supported in a sleeve 40 which can slide within a barrel member 30. The sleeve 40 has a stud 44 which projects through a slot 48 in the barrel, the stud enabling the sleeve to be slidably adjusted. The pendulous member 50 can swing freely about an axle 52 supported in the mechanism plate 56. When the optical axis of the camera is pointed at the foot of a subject to be photographed, Fig. 1, (not shown), the angle between that axis and the pendulous member 50 can be related to the focal distance, and this relation is used to determine by empirical calculation the shape of a cam surface 64 which is part of a control member 66, (see also) Fig. 7 (not shown). This is mounted on a bearing in plate 56, and is urged clockwise by a leaf spring 100. The studd 44 is held against the cam surface 64 by a U-shaped spring 104. Control member 56 is operated by a lever portion 68, and is shown in Fig. 3 as rotated to its maximum extent in an anti-clockwise direction. Pendulous member 50 has a disc portion 106, and the end 108 of a lever 110 bears against the disc portion, under the action of a spring 112, to act as a braking or locking device. The brake is disengaged when member 66 is rotated anti-clockwise from the position shown, a lug 74 thereon engaging under and lifting end 108 away from disc 106. Pendulous member 50 has a pin 120 which extends through an arcuate slot 124 in plate 56, and can engage with a receiver portion of member 66 (72), Fig. 7 (not shown). In sighting and focusing the camera, lever 68 is rotated in an anti-clockwise direction from the position shown, which disengages the brake lever. The camera is now sighted in the inclined position of Fig. 1 (not shown), so that pendulous member 50 takes up a gravity-oriented position dependent on the angle of tilt, and lever 68 released. This allows the brake lever 110 to be locked once more by spring 112 against disc 106, so holding member 50 in the position it has taken up. When lever 68 is released, it rotates clockwise under the action of spring 100 until a locating finger (126), Fig. 7 (not shown) on member 66 engages against pin 120. A pointer 70 on member 66 reads against a scale 30, indicating the distance to which the focusing mechanism is now set. Pin 44 is now urged against cam surface 64, and the sleeve 40, and hence lens 28, is set accordingly for the focusing at that particular distance. The lens can be adjusted manually by moving lever 68 until pointer 70 aligns with the required reading on scale 130.
Patent GB-1226003-A (GB)
IPC: G02B26/00
Filed: 1968-03-08
Abstract: 1,226,003. Photo-electric apparatus. J. DEMENT. March 8, 1968 [March 8, 1967], No. 11446/68. Heading G1A. [Also in Divisions G2 and H4] A light modulator comprises a light source 5 and sensor (not shown) in co-operation with a variable refracting and/or reflecting optical device comprising a fluid filled chamber G which has at least one flexible wall and is coupled by a conduit E to a pressure transducer to vary the fluidpressure in the chamber and thus vary the slope of the flexible wall at a rate between 0 and about 10<SP>5</SP>H 2  . Examples of the precise form of optical device include (a) walls A and B transparent, one or both walls being flexible; (b) a flexible wall A with a front or rear reflecting surface, and a rigid wall B; (c) a transparent wall A and reflective wall B, one or both walls being flexible; (d) a flexible hoop member D joining the walls A and B one of which may be flexible. One of the chamber walls may itself comprise an optical element e.g. a lens, Fig.1A (not shown), while Fig.1C (not shown) illustrates a device comprising a further chamber adjacent chamber G on the optical axis so that e.g. variation in pressure in chamber G will flex the wall common to both chambers and thereby change the pressure in the further chamber. In the case of (d), the hoop D may be of uniform flexibility to give e.g. a variable focus device, or of differential flexibility round its circumference to give a light deflector, Fig.1D (not shown). Several devices may share a common chamber G, Fig. 1B (not shown). The flexible wall A and/or B may additionally comprise a flexible diffraction grating, reference grid, polarizing member or hologram. Thus a series of concentric holograms may in turn be brought into focus for reconstruction. The variable focus devices may be used to vary the intensity of light at the sensor as the fluidpressure varies e.g. by variable area modulation or use of an appropriate stop, Figs.2 and 3 respectively (not shown), or to vary the length of a line produced by a slit stop, Fig. 5 (not shown). In addition, those devices also showing chromatic refraction may be used for colour modulation e.g. using an "onion" stop, Fig.4 (not shown) which modulation may be continuous or of the "onoff" type depending on the spectrum of the source 5. The light deflecting embodiment may be used with a knife edge to give intensity modulation e.g. for seismometry, vibration or stress analysis and control, or for edge profilometry, by replacing the knife edge by the test specimen. Other particular applications of the light modulators are those involving fluidic to electrical energy transduction e.g. in information storage or production, and in computers with fluidic to optical or electrical interfaces e.g. with fluidic logic circuits. Where several devices have a common chamber G, the time for the pressure variation to traverse the fluid will give a phase lag between different outputs, which outputs may be fed into a circuit for discriminating or filtering on the basis of response time or light intensity.
Patent GB-1226056-A (GB)
IPC: A23B4/06
Filed: 1969-07-07
Abstract: 1,226,056. Freezing food. MEAT RESEARCH INSTITUTE OF NEW ZEALAND (Inc.). 7 July, 1969 [15 July, 1968], No. 34064/69. Heading F4H. In a products-immersion refrigerating machine for handling frozen food, the food units are individually encapsulated in strip form and separated by perforations in an automatic packaging machine and fed from an endless conveyer 24 to a tray 16 where they are immersed in the refrigerant, which may be mono propylene glycol, and delivered to a further conveyer 26 where water sprays 27 remove the refrigerant. The apparatus comprises an evaporator tank 10, pump 12, distributing manifold 15 and freezing tray 16 there being a rung horizontal mesh 18 and wire frame pushers 23 to engage the product. A weir 17 at the outlet end of tray 16 leads back to the tank 10.
Patent GB-1231563-A (GB)
IPC: H04Q11/04
Filed: 1969-01-31
Abstract: 1,231,563. Automatic exchange systems. STANDARD TELEPHONES & CABLES Ltd. 29 Jan., 1970 [31 Jan., 1969], No. 5372/69. Heading H4K. In a TDM exchange incorporating a twostage crosspoint switching network, the problem of internal blocking is partially overcome by the provision of overflow links between the " outlets " of the switches in one stage. As shown, the " outlets " of each first stage switch S1 are connected to three group equipments GE while the inlets of the second stage switches S2 are connected to junctors which terminate TDM highways. Each group equipment effects conversion between eight TDM highways of the four wire type and two one-way highways VM1, VM2. The latter each comprise eight wires on which the eight serial PCM bits pertaining to a channel of a both-way highway are transmitted in parallel mode. Each both-way highway carries 24 channels utilizing 8 bit serial PCM. The interstage links IS comprise 16 wires (eight Go and eight Return) and carry 192 channels each of which occupies a time equivalent to 1 PCM bit on a both-way highway. The necessary control circuits for multiplexing the bothway highways on to the one-way highways with or without time slot interchange are not described. In setting up a call from say junctor 3 in the second S2 switch to a both-way highway attached to one of the group equipments in the lowermost S1 switch, a link IS6 is chosen preferentially. If this link is subject to blocking during the required time slot (or in all or nearly all slots, in a system providing time slot interchange) then an overflow route involving say link IS4, switch S1 and overflow link OL1 is selected. It is suggested that the completion of overflow through the group equipment associated with this third S1 switch is accomplished by means of logic circuitry included in the group equipment.
Patent GB-1239120-A (GB)
IPC: H01K1/50
Filed: 1969-12-24
Abstract: 1,239,120. Halogen lamp. TOKYO SHIBAURA ELECTRIC CO. Ltd. 24 Dec., 1969 [27 Dec., 1968], No. 62921/69. Heading H1F. A halogen lamp comprises a filament and a bulb containing the filament and nitrogen and/or an inert gas and a second gas containing chlorine and fluorine. The chlorine is present in the bulb at (0À05 to 1) Î 10<SP>-6</SP> gm. atoms/c.c. whilst the fluorine is present at (0À05 to 1À5) x 10<SP>-6</SP> gm. atoms/c.c. The second gas may be dichlorodifluoromethane (CF 2 Cl 2 ), 1,2-dichloro-1,1,2,2- tetrafluoroethane (C 2 Cl 2 F 4 ), chlorodifluoromethane (CClF 2 H), trichlorofluoromethane (CFCl 3 ), chlorotrifluoromethane (CClF 3 ), 1,1,2- trichloro - 1,2,2 - trffluoromethane (C 2 Cl 3 F 3 ) or 1-chloro-1-difluoroethane (C 2 H 3 F 2 Cl). Alternatively elemental chlorine, fluorine and carbon may be introduced into the bulb and caused to react therein. The fluorine and chlorine may be introduced by using SiF 4  or SiCl 4 . If chlorodifluoromethane is used then an additional fluorine-containing gas must be used to bring the hydrogen: fluorine ratio to the desired level otherwise excessive blackening of the bulb results. The inert gas may be Ar or Kr.