baber/WOPTO huggingface dataset:
Patent CA-3084460-A1 (CA)
Title: Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses
Inventor: YAO JIA
IPC: A61B5/145
Filed: 2019-01-22
Abstract: Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.
Patent CA-3085095-A1 (CA)
Title: Engineered o-glycosylation in recombinant polypeptides and uses thereof
Inventor: TIBBLES ADAM
IPC: C07K1/107
Filed: 2018-12-20
Abstract: The present invention relates to recombinant polypeptide therapeutics having an engineered O-linked amino acid (AA) glycosylation sequence (motif), which is covalently linked to O-glycan(s) (tag). Recombinant O-glycosylated polypeptides may be produced in mammalian cells to present natural or un-natural O-glycan structures through metabolic labelling
Patent CA-3085872-A1 (CA)
Title: System and method for a flexible pipe containment sled
Inventor: BARNETT ALEXANDER RYAN
IPC: F16L1/06
Filed: 2018-08-02
Abstract: A flexible pipe containment sled includes a platform and a first sled portion coupled to a bottom surface of the platform. The first sled portion is disposed at a first side of the platform. The sled also includes a second sled portion coupled to the bottom surface of the platform. The second sled portion is disposed at a second side of the platform opposite to the first side of the platform. The sled also includes a passage formed between the first and second sled portions. The passage is configured to allow a flexible pipe to pass through the passage while the flexible pipe containment sled is placed on a surface.
Patent CA-3086477-A1 (CA)
Title: Merchandiser including conductive coating to heat frame
Inventor: TWOHY RAYMOND P
IPC: B05D7/24
Filed: 2017-12-19
Abstract: A refrigerated merchandiser includes a case defining a product display area. A frame is connected to the case. The frame has a frame member with an exterior surface facing an ambient environment. A coating is on the exterior surface of the frame member. The coating includes conductive particles.
Patent CA-3088441-A1 (CA)
Title: Dispositifs d`antenne plaque jumeles et methodes
Inventor: HAUTCOEUR JULIEN
IPC: H01Q1/38
Filed: 2020-07-30
Abstract: Il est décrit une antenne plaques jumelées comprenant au moins deux antennes plaques en vue de fournir une antenne multifréquence ou à large bande. Cependant, lindépendance des fréquences de réponse résonantes des plaques inférieures et supérieures de chaque mise à terre de paire dantennes plaques jumelées exige que les dimensions de métallisation de la surface inférieure de la plaque supérieure soient inférieures aux dimensions de la métallisation résonante de la plaque inférieure. Par conséquent, la fréquence de résonance de la plaque inférieure souhaitée impose une limite aux dimensions de lélément de plaque jumelée composite. Il est décrit une structure physique différente dans laquelle la métallisation de la plaque de mise à terre de la surface inférieure du premier élément de plaque supérieure nimpose aucune limite à la géométrie de la plaque résonante de la métallisation supérieure de lélément de plaque inférieure. Il est également décrit des solutions de conception qui permettent de réduire la fréquence de fonctionnement inférieure de la première plaque inférieure composant une antenne plaques jumelées sans que cela nait dincidence sur lenvergure de lantenne ainsi obtenue.
Patent CA-3089528-A1 (CA)
Inventor: KOGLER RENE
IPC: C08L33/12
Filed: 2019-01-31
Abstract: The present invention relates to light scattering polymeric compositions with improved scattering efficiency and improved mechanical properties. The compositions comprise a polymeric matrix material and at least two different kinds of scattering particles uniformly dispersed therein.
Patent CA-3090422-A1 (CA)
Inventor: MORRISS JOHN
IPC: A61F2/24
Filed: 2012-10-19
Abstract: 86986880 ABSTRACT A prosthetic heart valve includes a flexible anchoring member at least partially surrounding and coupled to an inner valve support. The device can further include a prosthetic valve coupled to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts connected circumferentially by a plurality of struts, where the posts extend along an axial direction generally parallel to the longitudinal axis and the struts extend circumferentially around and transverse to the longitudinal axis. The posts extend an entire longitudinal height HI of the valve support 120. The device also includes one or more sealing members and tissue engaging elements like spikes. Date Recue/Date Received 2020-08-18
Patent CA-3090801-A1 (CA)
Title: Medical/surgical lavage unit with a tip assembly that includes an irrigation tube disposed inside a suction tube and that is axially offset from the suction tube
Inventor: KIDMAN BEAU
IPC: A61M3/02
Filed: 2013-12-05
Abstract: A medical/surgical lavage unit (50) that includes a tip assembly (650) with an irrigation tube (730) and a suction tube (750). The irrigation tube is disposed within and axially offset from the suction tube. The suction tube has a lumen (736) has with a relatively wide cross-sectional length that reduces clogging of waste in the lumen.
Patent CA-3091140-A1 (CA)
Inventor: WANG BEATRICE TIEN-YI
IPC: C07K16/30
Filed: 2019-02-25
Abstract: La présente invention concerne des méthodes thérapeutiques de traitement du cancer comprenant une polythérapie au moyen d'un anticorps anti-DR5 multimère et d'un agent chimiothérapeutique, par exemple, un inhibiteur de topoisomérase de type I, un analogue de nucléoside, ou un agent pro-apoptotique, par exemple, un inhibiteur de BCL -2.
Patent CA-3091889-A1 (CA)
Inventor: MAENTYLAE MARKKU
IPC: G01N21/3559
Filed: 2020-08-26
Abstract: A measurement apparatus of a moving paper web (100), comprises an optical radiation source (102) that outputs optical radiation toward a scattering element (104) of the measurement apparatus. The scattering element (104) scatters the optical radiation, and a transmitting surface (104A) of the scattering element (104) directs the optical radiation in a scattered manner toward the moving paper web (100). A distance (D) between said transmitting surface (104A) of the scattering element (104) and a surface of the paper web (100) is known, and said transmitting surface (104A) and a detector (106) of the apparatus are on opposite sides of the paper web (100). The detector (106) receives at least a part of the optical radiation, which is side-scattered from the moving paper web (100). The detector (106) determines a moisture value and a dry weight of the paper web (100) on the basis of spectral information on the received optical radiation and the known distance (D).
Patent CA-3092092-A1 (CA)
Title: Compositions et methodes pour inhiber l'expression de gys2
Inventor: BROWN BOB D
IPC: C12N15/63
Filed: 2019-02-15
Abstract: La présente invention concerne des oligonucléotides, des compositions et des procédés utiles pour réduire l'expression de GYS2, en particulier dans les hépatocytes. Les oligonucléotides pour la réduction de l'expression de GYS2 selon l'invention peuvent être bicaténaires ou monocaténaires, et peuvent être modifiés pour permettre d'obtenir des caractéristiques améliorées telles qu'une résistance plus forte aux nucléases et une immunogénicité plus faible. Les oligonucléotides pour la réduction de l'expression de GYS2 selon l'invention peuvent également comprendre des ligands de ciblage destinés à cibler une cellule ou un organe particulier, tels que les hépatocytes du foie, et peuvent être utilisés pour traiter des glycogénoses (par ex. GSDIa, GSDIII, GSDIV, GSDVI, et GSDIX) et des états associés.
Patent CA-3092199-A1 (CA)
Inventor: BAE JEE YEON
IPC: C12N15/67
Filed: 2019-03-15
Abstract: La présente invention concerne un nouveau promoteur et un procédé de production d'acide aminé de type L faisant appel à celui-ci.
Patent CA-3092944-A1 (CA)
Inventor: AANENSEN OISTEIN
IPC: G06F1/12
Filed: 2019-03-01
Abstract: L'invention concerne un procédé de correction de dérive d'horloge dans au moins une horloge esclave dans un nud sismique. Le procédé consiste à obtenir un certain nombre de mesures de dérive d'horloge de l'au moins une horloge esclave dans l'au moins un nud sismique. Une fonction de correction de dérive d'horloge en fonction du temps est calculée par un ajustement de courbe du nombre de mesures de dérive d'horloge sur un polynôme d'ordre 2. Un temps de référence des données de capteur sismique enregistrées est corrigé par la fonction de correction de dérive d'horloge polynomiale d'ordre 2.
Patent CA-3096155-A1 (CA)
Inventor: LIAO CHIEN-YI
IPC: A63B69/00
Filed: 2019-04-26
Abstract: Un dispositif d'entraînement de lancer de basketball (10) comprend un cadre principal (12), une première structure de rail vertical (14) ayant des rails verticaux et obliques (28, 30), une première base coulissante (16), et un premier élément d'imitation de basketball (18). La première structure de rail vertical (14) est disposée sur le cadre principal (12). La première base coulissante (16) est disposée coulissante sur la première structure de rail vertical (14) pour coulisser le long de la première structure de rail vertical (14). Le premier élément d'imitation de basketball (18) est relié à la première base coulissante (16). Lorsque le premier élément d'imitation de basketball (18) est soutenu et propulsé vers le haut par la main d'un utilisateur, la première base coulissante (16) coulisse d'une première position initiale sur le rail vertical (28) à une position de lancer sur le rail oblique (30) pour guider la main de l'utilisateur pour réaliser un lancer complet le long de la première structure de rail vertical (14).
Patent CA-3099710-A1 (CA)
Inventor: BESLEY TIM
IPC: F21L4/04
Filed: 2019-05-10
Abstract: The present disclosure provides a head lamp comprising: a light source; a power supply for powering the light source; and a chassis adapted to hold the light source, said chassis being receivable within a body formed from a resiliently flexible material, said body being adapted to be secured to a wearer's head.
Patent CA-3100609-A1 (CA)
Title: Wellbore clean-out tool
Inventor: JONES KEVIN DEWAYNE
IPC: E21B21/00
Filed: 2019-05-23
Abstract: A tool for cleaning out the lower end of a cased wellbore having an installed production string. The tool is lowered down the production string until it reaches a stationary position. In that position, a lower section of the tool projects through an opening at the base of the production string and into the wellbore. The tool sprays high pressure fluid from its fluid openings into nearby portions of the wellbore. To remove the tool from the production string, a deformable ball is lowered into a funnel sub installed within the tool. Fluid pressure is applied to the ball until the ball is extruded through the funnel sub and captured within a cage immediately below the funnel sub. Within the cage, the ball blocks upward flow of subterranean fluid into the funnel and through the tool. With no fluid passing through the tool, the upward fluid flow carries the tool to ground level.
Patent CA-3100943-A1 (CA)
Inventor: ZAHID MALIHA
IPC: A61K47/66
Filed: 2019-05-22
Abstract: Disclosed is a synthetic, non-naturally occurring 12-amino acid peptide, Cardiac Targeting Peptide, belonging to the larger class of cell penetrating peptides, for delivery of both diagnostic and potentially therapeutic agents to the heart. Also disclosed are subsequent generations of this Cardiac Targeting Peptide with improved, higher efficiency of cardiac uptake for CTP-mediated delivery of antiarrhythmics subjects for treating Atrial fibrillation or Ventricular fibrillation, CTP-mediated delivery of neuregulin-1ß for treating systolic heart failure (SHF), and Szeto-Schiller peptides for treatment of diastolic congestive heart failure, among other applications.
Patent CA-3103888-A1 (CA)
Inventor: ZENG WEIPENG
IPC: C07D417/14
Filed: 2019-07-29
Abstract: The invention provides methods for purifying isavuconazonium sulfate comprising the steps of - (a) providing a mixture comprising the sulfate salt of the compound of formula (I) and an aliphatic alcohol, wherein the pH of the mixture is in the range of about pH 1 to about pH 6; - (b) allowing a first portion of the sulfate salt of the compound of formula (I) to crystalize from the mixture; and - (c) adding an aprotic organic solvent to the mixture and allowing an additional portion of the sulfate salt of the compound of formula (I) to precipitate from the mixture.
Patent CA-3104740-A1 (CA)
Title: Below grade, blind side, waterproofing sheet membrane with adhesive and high reflectivity granular particle layer to fully bond to concrete/shotcrete, and a method of making, and using same
Inventor: RUDYAN AMIR
IPC: B32B5/16
Filed: 2020-12-31
Abstract: ABSTRACT OF THE DISCLOSURE The invention relates to a below grade, blind side, waterproofing sheet membrane with adhesive and high reflectivity granular particle layer, and having a top release liner, and a bottom release liner, enhancing bond strength between sheets, and be able to fully bond to concrete/shotcrete, and a method of making, and using same. The inventive waterproofing sheet membrane with adhesive, has at least one layer of high reflectivity granular particle layer that are fully or partly embedded into the adhesive layer, and where the average reflectivity of the exposed granular particles is between about 35 percent to 80 percent reflectivity on a standard reflectivity scale. The waterproofing sheet membrane has an adhesive layer having embedded therein high reflectivity granular particles is used in any building or wall construction, and can be placed under or around a foundation of a building or on its below grade blind side retaining walls, etc. Date recue/Date Received 2020-12-31
Patent CA-3105465-A1 (CA)
Inventor: TANAKA MASAYASU
IPC: A61P29/02
Filed: 2019-07-18
Abstract: The present invention pertains to a drug for the treatment and/or prevention of pain, more specifically to a medicinal preparation for external use to treat and/or prevent peripheral neuropathic pain, the medicinal preparation containing as an active ingredient N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide.
Patent CA-3106634-A1 (CA)
Title: Hepato-biliary-pancreatic tissues and methods of making same
Inventor: TAKEBE TAKANORI
IPC: C12N5/073
Filed: 2019-07-16
Abstract: Disclosed herein are hepato-biliary-pancreatic organoid ("HBPO" or "EBP organoid") compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.
Patent CA-3106859-A1 (CA)
Title: Poches contenant un principe actif reliees entre elles
Inventor: FRANSEN NELLY
IPC: A24B13/02
Filed: 2019-07-19
Abstract: L'invention concerne un produit contenant un principe actif convenant pour la libération d'un principe actif, comprenant une chambre de poche externe perméable à l'eau contenant une composition contenant un principe actif. Dans le produit, ladite chambre de poche est reliée à une autre chambre de poche contenant la même composition ou une autre composition, ce qui permet d'obtenir au moins deux chambres de poche reliées entre elles, chacune comprenant une composition, une section de séparation séparant une chambre de poche d'une autre. Chaque chambre de poche a une longueur d'environ 1 mm à environ 40 mm et une largeur ne dépassant pas environ 10 mm
Patent CA-3107429-A1 (CA)
Title: Hydraulic bypass circuit for a power
Inventor: YOUNG CHARLES
IPC: E02F9/20
Filed: 2019-07-25
Abstract: Disclosed embodiments include hydraulic systems (220; 238; 305) which provide power to lift, tilt and auxiliary (e.g., implement) functions, including high-flow auxiliary functions, with increased efficiency. Disclosed embodiments incorporate a single variable displacement pump (224C; 310) that supplies pressurized fluid to a main control valve (320) (e.g., for lift, tilt, and auxiliary functions) and a bypass circuit (340). The main control valve supplies fluid to control lift, tilt, and auxiliary flow for implements. The bypass circuit combines flow with the output of the auxiliary section of the main control valve to optionally provide high-flow for selected implements. The single variable displacement pump can then be set to different output flow levels, with the bypass circuit functioning differently under different conditions to optimize hydraulic flow to carryout various tasks under various conditions.
Patent CA-3107732-A1 (CA)
Title: Protein recognizing drug moiety of antibody-drug conjugate
Inventor: SOMA MASAKO
IPC: C12N1/21
Filed: 2019-07-26
Abstract: A protein that recognizes the drug moiety of an antibody-drug conjugate in which a drug represented by the formula is linked to an antibody via a linker; a method for measuring the concentration of the antibody-drug conjugate in the plasma of a mammal dosed with the antibody-drug conjugate using the protein; and a method for checking the tissue distribution of the antibody-drug conjugate in the mammal using the protein.
Patent CA-3108286-A1 (CA)
Title: Melanges de solvants pour souder des films retractables olefiniques, etiquettes retractables formees avec lesdits melanges de solvants et procedes d'obtention de soudures avec les dits melanges de solvants
Inventor: DENICOLA JR
IPC: C12P5/00
Filed: 2019-07-31
Abstract: L'invention concerne un mélange de solvants utilisable pour rendre collante une surface d'un film plastique, comprenant un solvant à base de terpène et un ou plusieurs solvants du groupe constitué par un alcane à chaîne droite, un alcane à chaîne ramifiée, un alcane cyclique, un alcane cyclique substitué, un éther à chaîne droite, un éther à chaîne ramifiée, un éther cyclique, un éther cyclique substitué, un diéther cyclique, un diéther cyclique substitué, une cétone à chaîne droite, une cétone à chaîne ramifiée, une cétone cyclique, une cétone cyclique substituée, un ester à chaîne droite et un ester à chaîne ramifiée.
Patent CA-3109231-A1 (CA)
Inventor: DONNELLY CHRISTOPHER
IPC: A61K31/00
Filed: 2019-08-16
Abstract: Disclosed herein are methods to treat a neurodegenerative disease comprising administering to a subject with a neurodegenerative disease a therapeutically effective amount of a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Also disclosed are methods to inhibit protein aggregation in a cell comprising contacting the cell with a composition comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Additionally disclosed are compositions comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease.
Patent CA-3109565-A1 (CA)
Title: A wood plastic composite
Inventor: ROSS CHRISTOPHER L
IPC: C08K5/54
Filed: 2018-08-14
Abstract: A capstock may be composed of a bimodal olefin resin and an additive. The bimodal olefin resin may be composed of a first polymer having a first polymer percentage by weight based on a total weight of the bimodal olefin resin and a second polymer having a second polymer percentage by weight based on the total weight of the bimodal olefin resin. The capstock may have a thickness in the range of about 0.0015 in. to about 0.0030 in. The capstock may also include one or more fillers or additives. A building material may be composed of the capstock with a core, in which the capstock and core are co-fabricated. The capstock and core may be include polymer resins including LLDPE, LDPE, MDPE, HDPE, UHMWPE, a polyamide, PET, PP, or PVC.
Patent CA-3109684-A1 (CA)
Inventor: BOEGLI CHARLES
IPC: G01J1/42
Filed: 2019-09-06
Abstract: A method for adaptively splitting a coherent primary light beam, comprising producing a desired far-field distribution by phase modulating the primary light beam with a Spatial Light Modulator (SLM), the primary coherent light beam being directed to reflect on a display element of the spatial light modulator, thereby avoiding any moving elements to shape the primary coherent light beam, extracting from the primary light beam, after it has passed the spatial light modulator, a monitoring beam and a main beam, measuring the monitoring beam with a camera, directing the desired far-field distribution in the monitoring beam on a sensor surface of the camera. In a first option, the method comprises guiding the primary beam through a first focusing element (L1) that is configured to focus the far-field distribution onto a focusing plane of the first focusing element as a real output distribution, and focusing the far-field distribution in the monitoring beam onto the sensor surface of the camera by means of the first focusing element. In a second option, the method comprises guiding the monitoring beam through a second focusing element (L2) that is configured to focus the far-field distribution on the sensor surface of the camera. For either the first or the second option, the method further comprises adjusting a dynamic range of the camera using a variable intensity regulator to control the intensity of the incoming monitoring beam as a function of the far-field distribution, and configuring a closed loop to enable a phase calculation for the display element of the spatial light modulator, whereby an output signal from the camera is input into the closed loop for a plurality of iterations of a phase-calculation algorithm performed by a controller, wherein in the first option, the first focusing element is used, excluding the second focusing element, and in the second option, the second focusing element is used, excluding the first focusing element.
Patent CA-3110248-A1 (CA)
Title: Ophthalmic compositions and methods for the treatment of eye disorders and skin diseases
Inventor: KANDULA MAHESH
IPC: A61K31/00
Filed: 2019-07-09
Abstract: The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V and formula VI and the methods for the treatment of eye disorders and skin diseases and may be formulated for the topical eye drop, topical paste, ocular solution, device-drug delivery, oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, nasal spray, oral solution, cream, dermal ointment, gels, lotions, suspension, oral spray, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of skin diseases such as acne, rosacea and eye disorders such as ocular redness, glaucoma, presbyopia, IOP, cataract, dry eye and oGVHD.