baber/WOPTO huggingface dataset:
Patent CA-2677571-A1 (CA)
Inventor: BRETON MARCEL P
IPC: C09D11/00
Filed: 2009-09-03
Abstract: An ink including stabilized magnetic single-crystal nanoparticles, wherein the value of the magnetic anisotropy of the magnetic nanoparticles is greater than or equal to 2 x 10 4 J/m3.  The magnetic nanoparticle may be a ferromagnetic nanoparticle, such as FePt.  The ink includes a magnetic material that minimizes the size of the particle, resulting in excellent magnetic pigment dispersion and dispersion stability, particularly in non-aqueous inkjet inks.  The smaller sized magnetic particles of the ink also maintains excellent magnetic properties, thereby reducing the amount of magnetic particle loading required in the ink.
Patent CA-2679696-A1 (CA)
Inventor: GROELKE JOHN W
IPC: C07K16/30
Filed: 2008-03-07
Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal^ antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
Patent CA-2680670-A1 (CA)
Inventor: SCHLEMMER ROBERT P
IPC: E21B49/00
Filed: 2008-03-12
Abstract: An apparatus for testing a drilling fluid includes a vessel having a fluid inlet, a fluid outlet, and a pair of opposed impermeable platens disposed within the vessel. The apparatus further includes a test fluid container in fluid communication with the fluid inlet, and a collection container in fluid communication with the fluid outlet. Additionally, the system includes a data acquisition device configured to receive data from at least one of the vessel, the test fluid container, and the collection container. Also, a method for determining sealing characteristics of a drilling fluid includes injecting a test fluid having a fluid loss control material from a test fluid container to a vessel, the vessel having a first impermeable platen and a second impermeable platen with a gap between the two platens. The methods further includes measuring a fracture tip fluid loss through the gap.
Patent CA-2681354-A1 (CA)
Title: Dispositif de variation de section de tuyere secondaire associe a un inverseur a portes a dispositif de lissage de veine
Inventor: CARUEL PIERRE
IPC: F02K1/72
Filed: 2008-02-22
Abstract: Cet inverseur de poussée à porte(s) comprend : - une structure fixe (13), - au moins une porte (11) montée pivotante sur cette structure fixe (13) en tre une position fermée où elle définit une cavité et une position ouverte, - au moins un panneau de cavité (23) monté coulissant sur ladite porte (11) entre une position fermée dans laquelle il obture ladite cavité et une posit ion ouverte, et - des moyens d'actionnement (19; 19a, 19b) de ladite porte ( 11) et dudit panneau de cavité (23). Cet inverseur de poussée est remarquabl e en ce qu'il comprend un panneau de tuyère (31) monté coulissant sur ladite structure fixe (13), et des moyens (33, 35) pour coupler ledit panneau de t uyère (31) audit panneau de cavité (23) lorsque ladite porte (11) est fermée , puis pour coupler ledit panneau de tuyère (31) à ladite porte (11) lorsque ladite porte (11) passe de sa position fermée à sa position ouverte.
Patent CA-2686451-A1 (CA)
Inventor: DUBOIS GRANT E
IPC: A23L27/00
Filed: 2008-05-16
Abstract: The present invention provides substantially water soluble, substantially non-dusting delivery systems for natural high-potency sweeteners, methods for their formulation, and uses. In particular, the present invention relates to different delivery systems of sweetener compositions comprising at least one non-caloric or low-caloric natural high-potency sweetener.
Patent CA-2687721-A1 (CA)
Inventor: MESLEH MICHAEL
IPC: A61P25/08
Filed: 2008-06-06
Abstract: The present invention is directed to novel salts of (R)-1-{2-[4'-(3-methoxy-propane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine, and crystalline forms, and compositions thereof that modulate the activity of the histamine H3-receptor and are useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, pain, dementia, Alzheimer's disease and the like.
Patent CA-2688547-A1 (CA)
Inventor: SVIRIDOV SERGUEI
IPC: A61K31/381
Filed: 2008-06-05
Abstract: This invention is directed to compounds of formula (I), wherein m, formula (II), R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.
Patent CA-2689360-A1 (CA)
Inventor: MARTIN JIMENEZ ROCIO
IPC: A23L29/00
Filed: 2008-06-02
Abstract: The present invention relates to a novel approach to prevent or treat mastitis both in humans and animals through the use of mammal milk-derived microorganisms obtained from healthy hosts of the homologous species; to those new probiotic microorganisms obtained from milk able to reduce infectious mastitis and the method of screening used for their obtaining; to the use of these probiotic bacteria for the prophylaxis or treatment against mastitis and other diseases; and finally, to compositions comprising these compounds.
Patent CA-2689909-A1 (CA)
Title: Long-acting polymeric prodrugs of exendin
Inventor: RAU HARALD
IPC: C07K14/605
Filed: 2008-06-05
Abstract: Long-acting polymer exendin-4 or exendin agonist derivatives of the formula Pol-L-E are provided wherein Pol is a polymer, L is a releasing linker undergoing slow autohydrolysis and E is an exendin or exendin agonist. Theseexendin or exendin agonists are slowly released from Pol-L upon administration to a living organism. The derivatives are useful e.g. for the treatment of diabetes mellitus.
Patent CA-2690165-A1 (CA)
Title: Method for the production of a microfluidic system on a polymer surface
Inventor: FINKE WERNER
IPC: B29C59/16
Filed: 2008-06-20
Abstract: The invention relates to a method for producing a microfluidic system on a polymer surface, wherein at least one portion of the polymer surface is irradiated by laser light in a targeted fashion for the spatially-resolved modification of the wettability of the portion of the polymer surface by a liquid sample.
Patent CA-2692794-A1 (CA)
Inventor: HORTON ROBERT L
IPC: E21B33/13
Filed: 2008-07-01
Abstract: A method of reducing fluid loss from a wellbore that includes emplacing a fluid loss pill in the wellbore, the fluid loss pill comprising: a base fluid; a hydratable or solvatable synthetic copolymer having at least one crosslinkable comonomer; and a crosslinking agent is disclosed.
Patent CA-2693946-A1 (CA)
Title: Trash tolerant filter support for a disc filter
Inventor: DAVIS WILLIAM E
IPC: B01D25/00
Filed: 2008-07-16
Abstract: A filter device for filtering a liquid which includes trash. The device includes a drum for receiving the liquid and trash, wherein the drum includes at least one drum aperture. The device further includes a first pair of filter panels which are adapted for filtering the liquid. The filter panels are spaced apart to form a cavity for receiving the liquid and trash. The device further includes a frame for supporting the filter panels, wherein the frame is coupled to the drum. The frame includes a frame aperture wherein the frame aperture and the cavity form a volume having a cross sectional area sized substantially equal to or greater than the drum aperture and wherein said volume extends to a second pair of filter panels to enable liquid and trash which pass through the drum aperture to also pass through the frame aperture to the second pair of filter panels.
Patent CA-2696816-A1 (CA)
Title: Apparatus and method for fluid property measurements
Inventor: VAN ZUILEKOM ANTHONY H
IPC: E21B49/08
Filed: 2008-05-09
Abstract: In some embodiments, apparatus and systems, as well as methods, may operate to measure formation fluid and obtain data, the data having measurement levels that vary over a parameter. The data is grouped in one or more categories, each category having data falling within a range, and the grouped data is analyzed as a function of the parameter. In some embodiments, the grouped data is used to identify at least one fluid type of the formation fluid using the grouped data.
Patent CA-2697892-A1 (CA)
Title: Two-axle truck for a railway car and a railway car
Inventor: KIKKO SATOSHI
IPC: B60B17/00
Filed: 2008-08-22
Abstract: Lateral pressure which develops in the front wheelset when traveling along a curved track is decreased while suppressing an increase in costs as much as possible.  A two-axle truck for a railway car has a front wheelset having wheels with a first tread gradient and a rear wheelset having wheels with a second tread gradient which is different from the first tread gradient. The tread gradient of the wheels of the rear wheelset is larger than the tread gradient of the wheels of the front wheelset.
Patent CA-2700159-A1 (CA)
Inventor: ROBINSON RONNI L
IPC: A61K8/11
Filed: 2008-10-10
Abstract: The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that povides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.
Patent CA-2700859-A1 (CA)
Inventor: GERSHOW MARC H
IPC: C12Q1/68
Filed: 2008-10-02
Abstract: In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A  detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
Patent CA-2704354-A1 (CA)
Title: Expression of lipoproteins
Inventor: HUEBNER ROBERT C
IPC: C07K14/195
Filed: 1996-06-05
Abstract: Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be E. coli. The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the Borrelia OspA leader sequence. The protein portions can be OspC, PspA, UreA, UreB, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.      Specifically, the invention relates to a hybrid nucleic acid molecule, comprising a first nucleic acid sequence encoding a signal sequence (such as OspA) of a lipoprotein and a second nucleic acid sequence encoding a mature protein (such as PspA, UreA or UreB).      The invention also relates to expression vectors containing the hybrid nucleic acid molecule; methods and processes for providing recombinant proteins; recombinant proteins and uses and compositions thereof; and methods of enhancing the immunogenicity of a protein.
Patent CA-2706990-A1 (CA)
Inventor: BUETTELMANN BERND
IPC: A61P25/28
Filed: 2008-11-25
Abstract: The present invention is concerned with isoxazolo-pyrazine derivatives of formula (I) wherein X is O or NH; R1 is phenyl or pyridine-2-yl, wherein the rings may be optionally substituted with one, two or three halo; R3 is H or C1-4alkyl; R3 and R4 each are independently H, optionally substituted C1-7alkyl, optionally substituted C1-7alkoxy, CN, halo, NO2, -C(O)-R a -C(O)-NR b R c or R3 and R4 together form an optionally substituted annelated benzo ring, or a pharmaceutically acceptable salt thereof, having affinity and selectivity for GABA A .alpha.5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
Patent CA-2709770-A1 (CA)
Inventor: ROBINSON RONNI L
IPC: A61H15/00
Filed: 2008-12-19
Abstract: The present invention is directed to a reusable pain relieving treatment device, such as a belt, that comprises one or more conductive members that extend from an inner surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable packs.
Patent CA-2713221-A1 (CA)
Inventor: HUMENIUK DAVID P
IPC: G06F19/00
Filed: 2009-02-27
Abstract: A power injector (10) with help functionality is disclosed. What may be characterized as a'help output' may be displayed on a graphical user interface (11) in response to a request for help. This help output may be based upon a current state of the power injector (10), may be accompanied by a cross-reference to an operator's manual for the power injector (10), may be expanded to provide additional detail, or any combination thereof.    At least one system screen that relates to the help output may be displayed (e.g., simultaneously, sequentially).  The help functionality may be in the form of having the power injector (10) incorporate help mode logic (256) that is configured to allow a user to view and obtain information on the various system screens that would be presented when using the power injector (10) to deliver a fluid, but without actually operating the power injector (10) to deliver fluid.
Patent CA-2714050-A1 (CA)
Inventor: TOUR JAMES M
IPC: C09K8/035
Filed: 2009-01-08
Abstract: Drilling fluids comprising graphenes and nanoplatelet additives and methods for production thereof are disclosed. Graphene includes graphite oxide, graphene oxide, chemically-converted graphene, and functionalized chemically-converted graphene. Derivatized graphenes and methods for production thereof are disclosed. The derivatized graphenes are prepared from a chemically-converted graphene through derivatization with a plurality of functional groups. Derivatization can be accomplished, for example, by reaction of a chemically-converted graphene with a diazonium species. Methods for preparation of graphite oxide are also disclosed.
Patent CA-2719402-A1 (CA)
Title: Process for preparation of benzo-fused heteroaryl derivatives
Inventor: BALLENTINE SCOTT A
IPC: A61K31/357
Filed: 2008-03-26
Abstract: The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.
Patent CA-2721524-A1 (CA)
Inventor: DANG PHU
IPC: A63H5/00
Filed: 2010-11-17
Abstract: A method, system, and medium are provided for a wireless musical figurine belonging to a set of wireless musical figurines that play audio files in coordination with one another. One system of the musical figurine includes a wireless transceiver utilized to communicate with one or more musical figurines. The musical figurine also includes a set of master audio files of a first quality level, and a set of slave audio files of a second quality level. An audio player plays an audio file from the set of master audio files or the set of slave audio files. A master audio file is played when the musical figurine is initiated in accordance with a user indication, and a slave audio file is played when the musical figurine is initiated by another musical figurine. The musical figurine may also have movement capabilities which may be coordinated with the playing of an audio file to present a dancing figurine.
Patent CA-2723454-A1 (CA)
Inventor: CASSAYRE JEROME YVES
IPC: C07D401/14
Filed: 2009-05-13
Abstract: A compound of formula (I): wherein R1 is pyrid-4-yl optionally substituted by one to four substituents independently selected from halogen, C1-3 alkyl or C1-3 haloalkyl; R1 is hydrogen, halogen, C1-4 haloalkyl or C1-4 haloalkoxy; R3 is trifluoromethyl, difluoromethyl or difluoromethoxy and R4 is hydrogen, fluoro or chloro, or R3 is fluoro, chloro or bromo and R4 is fluoro, chloro or trifluoromethyl; and R5 is hydrogen or halogen; or salts or N-oxides thereof. Furthermore, the present invention relates to intermediates used to prepare compounds of formula (I), to methods of using them to combat and control insect, acarine, mollusc and nematode pests and to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them.
Patent CA-2723863-A1 (CA)
Inventor: MALMBERG MATS
IPC: B07B1/28
Filed: 2009-04-30
Abstract: The present invention concerns an adapter system for fixing different screening media (14, 22) to a vibrating screen. By means of the adapter system different side hold downs (15, 23) used for different screening media may be fixed to a wall (11) of the vibrating screen without any modifications of the wall (11).  The adapter system comprises an insert (1) to be placed in an opening of the wall (11). An adapter (2, 8, 9) is attached to the insert (1) at a desired height in relation to the insert (1). The insert (1) has a number of parallel grooves (4) co-operating with parallel ribs (5) on the adapter (2, 8, 9) in order to attached the adapter (2, 8, 9) to the insert (1).
Patent CA-2724376-A1 (CA)
Inventor: GOLDING BERNARD
IPC: C07D239/84
Filed: 2009-05-13
Abstract: This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treat-ment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim 1: and which have utili-ty as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
Patent CA-2725602-A1 (CA)
Inventor: BLACK MICHAEL ALAN
IPC: C12Q1/68
Filed: 2008-05-23
Abstract: The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determin-ing the prognosis of cancer in a patient, particularly for melanoma.  Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
Patent CA-2730010-A1 (CA)
Inventor: WILSON KEVIN
IPC: C07D413/12
Filed: 2009-07-01
Abstract: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Patent CA-2731165-A1 (CA)
Inventor: GORE VINAYAK
IPC: A61K31/135
Filed: 2009-07-29
Abstract: The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV) or a salt thereof, comprising the reaction of venlafaxine, or a salt thereof, with a thiourea or a mixture of thioureas.
Patent CA-2731344-A1 (CA)
Title: A hardenable two part acrylic composition
Inventor: CHISHOLM MICHAEL STEPHEN
IPC: A61L24/06
Filed: 2009-08-13
Abstract: The invention relates to a hardenable two part acrylic composition, a polymer component of the two part hardenable composition and a method of producing a polymer component of the two part composition. The hardenable two part acrylic composition comprises an acrylic polymer composition first part and an acrylic monomer composition second part. The acrylic polymer composition first part comprises a first type of acrylic polymer particles characterized in that each first type of acrylic polymer particle is formed of a network of coalesced emulsion polymerized acrylic microparticlesor is microporous. The acrylic polymer composition may comprise emulsion polymerised acrylic polymer particles of particle size between 10 and 2000nm.The invention also extends to the use of acrylic polymer particles formed of a network of coalesced emulsion polymerized acrylic microparticles as a dough time reduction agent in a hardenable two part acrylic composition.
Patent CA-2732428-A1 (CA)
Inventor: IRASCHKO JOHANN
IPC: F16D65/56
Filed: 2009-07-31
Abstract: An adjusting device for adjusting for wear of brake linings and of a brake disk of a pneumatically actuated disk brake, having a rotary-lever-actuated brake application device which can preferably be inserted into an adjusting spindle of the disk brake and attached to a brake caliper of the disk brake by means of a mounting disk, wherein an axial bearing is formed axially on one side of a drive ring and a ball ramp coupling with a freewheel function is formed axially on the opposite side of the drive ring; the ball ramp coupling has balls, has the drive ring arranged at the drive-input side axially between the axial bearing and the balls thereof, and has a drive-output-side coupling ring, a cone coupling is arranged between the drive-output-side coupling ring and a spring sleeve for a cylindrical spring, is characterized in that a torque-dependent coupling with positive restraint is arranged axially between the cone coupling and the spring sleeve, and a corresponding disk brake.
Patent CA-2732795-A1 (CA)
Inventor: GARDNER SUSANNE
IPC: A23L2/00
Filed: 2009-06-10
Abstract: Described herein are beverages having a natural additive composed of one or more components derived from wine.  In certain aspects, the beverages composed of one or more components derived from defortified wine have optional other additives.  Components derived from defortified wine can be used to supplement an existing beverage or used to form a new beverage.