Patent SG-11201810970W-A (SG)
Title: Anti-egfr antibody drug conjugates
Inventor: BOGHAERT ERWIN
IPC: A61P35/00
Filed: 2017-06-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 01E111 11111 MEMO 0111111MIMIDIE MIME ill 1111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/214282 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: COWLES, Cristin H. et al.; Womble Carlyle San- CO7K 16/28 (2006.01) A61P 35/00 (2006.01) dridge & Rice, LLP, P.O. Box 7037, Atlanta, Georgia 30357 A61K 47/68 (2017.01) A61P 43/00 (2006.01) (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/036368 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 07 June 2017 (07.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/347,416 08 June 2016 (08.06.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, IL 60064 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: BOGHAERT, Erwin, R.; 4510 Springbrook GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Road, Pleasant Prairie, WI 53158 (US). SOUERS, An- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, drew, J.; 156 Blueberry Road, Libertyville, IL 60048 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PHILLIPS, Andrew, C.; 519 Garfield Avenue, Liber- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, tyville, IL 60048 (US). JUDD, Andrew,S.; 138 Main- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, sail Drive, Grayslakc, IL 60030 (US). BRUNCKO, Milan; TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 31231 Prairie RidgeRoad, Green Oaks, IL 60048 (US). KM, ML, MR, NE, SN, TD, TG). = = = (54) Title: ANTI-EGFR ANTIBODY DRUG CONJUGATES = z\"40 R 12 ' OH N = R2 R', Z 28-- '# (Ha) 1 = _ = HN 0 N = R 1 R ill) = CI R1le Z 2b = = = R 0 OH N R2 R 13 # = = 2 'ri (11b) 1 R4 = HN 0 N R 1 = f R1 1 1 1a R ilb CI R 4 Il .4 1 2b N. Z #-.\" R• OH ei N R2 /1113) R' GC el 2 a oic) • 7 1 71' HN 0 N Il R 1 ei CI R11' R 11 b IN 11 N (57) : The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit _ Bc1-xL, including compositions and methods of using said ADCs. Formula (IIa), (llb), (IIc) [Continued on next page] WO 2017/214282 Al MIDEDIMOMMIMMEMODIOHOIDIEHEIHIMEMOIS Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of earlier application (Rule 4.17(iii)) the Published: — with international search report (Art. 21(3)) — with amended claims (Art. 19(1)) — with sequence listing part of description (Rule 5.2(a))