Patent SG-11201807652S-A (SG)
Title: Derivatives of amanita toxins and their conjugation to a cell binding molecule
Inventor: ZHAO ROBERT YONGXIN
IPC: C07K7/64
Filed: 2016-04-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/046658 Al 23 March 2017 (23.03.2017) WIPO I PCT (51) International Patent Classification: A61K 47/50 (2017.01) A61P 35/00 (2006.01) CO7K 7/64 (2006.01) (21) International Application Number: PCT/IB2016/052246 (22) International Filing Date: 20 April 2016 (20.04.2016) (25) Filing Language: English (26) Publication Language: English (71) Applicant: HANGZHOU DAC BIOTECH CO, LTD [CN/CN]; Building 12, Zhongzi Technology Park, No. 260 Sixth Street, Heda, Hangzhou City, Zhejiang 310018 (CN). (72) Inventors: ZHAO, Robert Yongxin; Room B2005, Build- ing 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). YANG, Qingliang; Room B2006, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). HUANG, Yuanyuan; Room B2006, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). GAL Shun; Room B2003, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). YE, Hangbo; Room B2004, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). YANG, Chengyu; Room B2009, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). GUO, Huihui; Room B2002, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). ZHOU, Xiaomai; Room B2005, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). XIE, Hongsheng; Room B2006, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). TONG, Qianqian; Room B2011, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). CAO, Minjun; Room B2002, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). ZHAO, Linyao; Room B2005, Building 2, Room B2007, Building 2, No. 452 Sixth Street, Heda Hangzhou, Zhejiang 310018 (CN). JIA, Junxiang; Room B2015, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). LI, Wenjun; Room B2005, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). ZUO, Xiaotao; Room B2008, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). LIN, Chen; Room B2012, Build- ing 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). XU, Yifang; Room B2008, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). GUO, Zixiang; Room B2013, Building 2, No. 452 Sixth Street, Heda, Hangzhou, Zhejiang 310018 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] = (54) Title: DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE Q (a) (57) : Derivatives of Amernita toxins of Formula (I), wherein, formula (a) R 1, R 2, R3, R 4, R s, R 6, R7, R 8, R 9, R io , X, L, m, n and Q are defined herein. The preparation of the derivatives. The therapeutic use of the derivatives in the targeted treatment of cancers, autoimmune disorders, and infectious diseases. 111111111111110111011111111111010111110011111111111111111111111111110111111111110111111 W O 20 17 /0 4665 8 Al WO 2017/046658 Al MIDEDIMOM010101g010111110011INIMIMMINVOIMIE SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(1)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) upon request of the applicant, before the expiration of the time limit referred to in Article 21(2)(a)