Patent SG-11201910172V-A (SG)
Title: Substituted bicyclic heterocyclic compounds as nadph oxidase inhibitors
Inventor: KUMAR SUKEERTHI
IPC: A61K31/496
Filed: 2018-05-04
Abstract: International Patent Classification: C07D 471/04 (2006.01) A61P 35/00 (2006.01) C07D 491/052 (2006.01) A61K 31/437 (2006.01) CO7D 495/04 (2006.01) A61K 31/5377 (2006.01) CO7D 498/04 (2006.01) A61K 31/444 (2006.01) CO7D 513/04 (2006.01) A61K 31/496 (2006.01) A61P 11/00 (2006.01) A61K 31/4545 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT 01E101°1a °nolo oloionoolomim io Elio ow (10) International Publication Number WO 2018/203298 Al PCT/IB2018/053121 (22) International Filing Date: 04 May 2018 (04.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201721015787 04 May 2017 (04.05.2017) IN (71) Applicant: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la Combeta 5, 2300 La Chaux-de- Fonds (CH). (72) Inventors: KUMAR, Sukeerthi; 404A, Vardhaman En- clave, Plot No. 3, Sector-20, Airoli, Maharasthra, Navi Mumbai 400708 (IN). CHAUDHARI, Sachin Sundar- lal; 15/304, FAM C.H.S., Sector # 11, Koparkhairane, Maharashtra, Navi Mumbai 400709 (IN). GHARAT, Laxmikant Atmaram; Flat No-203, Tirupati Apartments, Pokhran road no — 2, Majiwada, Maharashtra, Thane (W) 400601 (IN). KHAIRATKAR-JOSHI, Neelima; C-101, Devprayag CHS, Bhakti Mandir Rd, Hari Niwas, Panch- pakhadi, Maharashtra, Thane (W) 400602 (IN). SHAH, Daisy Manish; Padmashree Bldg, 1st Floor, Flat no 4, Anant Patil Marg, Gokhale Road, Dadar (W), Mumbai 400028 (IN). MUKHOPADHYAY, Indranil; Flat No. 502, 'LILY' Kesar Garden, Plot- 53, Sector-20, Kharghar, Maharashtra, Navi Mumbai 410210 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17 (ii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE 00 Cr) O 00 O 1-1 C (54) Title: SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS (57) : The present application relates to substituted fused heteroaryl and hetero- cyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treat- ment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I) (R1). Z1 z z 3 L 4