Patent SG-11201809301Y-A (SG)
Title: Isoquinolin-3-yl carboxamides and preparation and use thereof
Inventor: KC SUNIL KUMAR
IPC: C07D217/00
Filed: 2017-04-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 November 2017 (02.11.2017) WIP0 I PCT omit IIl Hot 0 OH 11°111111E1m io 111110lII ow (10) International Publication Number WO 2017/189829 Al (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/4725 (2006.01) C07D 217/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/US2017/029805 (22) International Filing Date: 27 April 2017 (27.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/328,255 27 April 2016 (27.04.2016) US (71) Applicant: SAMUMED, LLC [US/US]; 9381 Judicial Drive, Suite 160, San Diego, CA 92121 (US). (72) Inventors: KC, Sunil Kumar; 10504 Clasico Court, San Diego, CA 92127 (US). MAK, Chi Ching; 12057 World Trade Drive, Unit 3, San Diego, AZ 92128 (US). EAST- MAN, Brian, Walter; 10518 Caminito Pollo, San Diego, CA 92126 (US). CAO, Jianguo; 9898 Avenger Court, San Diego, CA 92126 (US). BOLLU, Venkataiah; 10715 Wexford St. #6, San Diego, CA 92131 (US). MITTAPAL- LI, Gopi Kumar; 4158 Decoro Street #47, San Diego, CA 92122 (US). CHIRUTA, Chandramouli; 4158 Deco- ro Street, Apt. 61, San Diego, CA 92122 (US). Published: — with international search report (Art. 21(3)) (74) Agent: DORIGO, Andrea et al.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, MN 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 N (54) Title: ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF 00 01 (57) : Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present *t invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation 1-1 f'1 Also provided are methods for treating Wnt-related disease states. of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, IN and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological © conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components.