baber/WOPTO huggingface dataset:
Patent CA-2373856-A1 (CA)
Title: 1-arylcycloalkyl sulphides, sulphoxides and sulphones for the treatment of drug misuse or addictive disorders
Inventor: NEEDHAM PATRICIA LESLEY
IPC: C07C317/28
Filed: 2000-06-21
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula  (II) in which R5 is H or alkyl; Y is an alkylene chain optionally substitute d by one or more alkyl groups; Z is an alkylene chain containing 2 to 5 carbon  atoms optionally substituted by one or more alkyl groups; R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; an d R1 and R2, which are the same or different, are H, alkyl, or arylalkyl, provided that when R1 is benzyl, R2 is H or methyl; have utility in the treatment of drug misuse or other addictive disorders.
Patent CA-2375102-A1 (CA)
Inventor: KHURI SHUKRI F
IPC: A61B5/296
Filed: 2000-05-26
Abstract: The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Real time tissue pH  measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site.
Patent CA-2375569-A1 (CA)
Title: Method and apparatus for inserting and propelling a coating device into and through live gas pipeline
Inventor: NICHOLS RANDALL A
IPC: F16L55/162
Filed: 2000-06-21
Abstract: A system and method for inserting a coating device into the passageway of a live gas pipeline and for laterally propelling said coating device through said passageway, said system comprising an entry flange having an orifice operatively connected to pipeline, a primary retention seal having an orifice operatively connected to said entry flange, a mounting plate operatively connected to said retention seal and a propulsion unit operatively connected to said mounting plate. The method comprises exposing a section of live gas pipe, creating bypass, removing portion of bypassed pipe thereby exposing an opening in said live gas pipe, attaching entry flange to said opening, inserting coating unit attached to flexible conduit through said entry flange, attaching propulsion unit to entry flange and said flexible conduit and actuating propulsion unit to propel said flexible conduit through live gas pipe.
Patent CA-2378543-A1 (CA)
Inventor: KWON SE CHANG
IPC: C12R1/19
Filed: 2000-07-07
Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid.
Patent CA-2379686-A1 (CA)
Inventor: SHERMAN ROBYN ANN
IPC: B60R22/48
Filed: 2000-07-27
Abstract: A harness safety alarm for providing a warning in the event that a seat belt  is uncoupled comprises a proximity sensor (19) connected by straps (20, 21) to a seat belt buckle (13). A detectable means (22), such as a magnet, is attached by strap (23) to the tongue (16) of the seat belt. A warning unit (30), which is mounted remotely from the proximity sensor (19), provides an audible and visual warning if the seat belt is uncoupled. In particular, if the seat belt is uncoupled, the sensing means (19) sends a radio frequency signal to the warning unit (30) to thereby activate the audible and visual warning.
Patent CA-2379818-A1 (CA)
Title: Catalytic anti-factor viii allo-antibodies
Inventor: KAZATCHKINE MICHEL
IPC: A61K38/08
Filed: 2000-07-18
Abstract: The present invention relates to a method of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor VIII molecule by said catalytic anti-Factor VIII allo-antibodies. It also relates  to an anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor; and to a pharmaceutical composition comprising said catalytic ant i- Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination; and further to a pharmaceutical composition comprising said anti-Factor VIII allo-antibody- catalysed Factor VIII degradation inhibitor. Finally, the present invention relates to the application in therapeutics of said anti-Factor VIII allo- antibody-catalysed Factor VIII degradation inhibitor, of a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which  are capable of degrading Factor VIII and which originate from said method of  determination, and of a pharmaceutical composition comprising said anti-Fact or VIII allo-antibody-catalysed Factor VIII degradation inhibitor.
Patent CA-2380339-A1 (CA)
Title: Procede diagnostique
Inventor: HEAGERTY ANTHONY MICHAEL
IPC: G01N33/49
Filed: 2000-06-29
Abstract: La présente invention concerne un procédé pour diagnostiquer ou détecter une prédisposition à l'hypertrophie cardiaque, qui consiste à effectuer des dosages in vitro d'un échantillon de liquide corporel afin d'établir le taux cardiotrophine-1 (CT-1), ainsi que des procédés d'utilisation correspondants.
Patent CA-2380624-A1 (CA)
Inventor: BEDALOV ANTONIO
IPC: G01N33/574
Filed: 2000-10-02
Abstract: The present invention relates to composition and methods of identifying one or more secondary drug targets and their use in the identification of drugs or drug candidates, particularly for the treatment of cancer or cell replication disorders. The yeast-based synthetic lethal screens are used to functionally identify and validate new gene targets to kill cells with defects in cell cycle pathways. These newly identified gene targets can be used to develop new therapeutics to treat cancer, benign cell growth, and yeast infections.
Patent CA-2381712-A1 (CA)
Title: Odorant-binding human proteins fixing hydrophobic ligands: polypeptides and polynucleotides coding for said polypeptides and uses thereof
Inventor: LACAZETTE ERIC
IPC: A23L1/305
Filed: 2000-08-11
Abstract: The invention concerns novel polypeptides fixing hydrophobic ligands and in particular odours, called OPBII (Odorant Binding Protein), the polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns the uses of said molecules for personal hygiene, uses in agri-food system and nutritional and therapeutic uses
Patent CA-2383471-A1 (CA)
Inventor: ATHERTON ERIC
IPC: G01N17/02
Filed: 2001-06-08
Abstract: A corrosion monitor comprising electronic circuitry arranged such that DC  current flowing between two electrodes is reduced to essentially zero, while allowing any naturally occurring AC current noise to flow unhindered and be monitored by the instrumentation. The two electrodes consist of one inert reference electrode, and one electrode constructed of the material to be monitored (the working electrode). Even though the two electrodes will have different galvanic potentials, by reducing the DC current to zero the electronic circuitry is able to avoid galvanic effects. Furthermore, the voltage potential can be monitored between the inert current reference electrode, and a third electrode also constructed of an inert material. As corrosion activity occurs on the working electrode, both current noise and voltage noise may then be monitored simultaneously.
Patent CA-2384809-A1 (CA)
Inventor: KOLB ROBERT E
IPC: C07C69/63
Filed: 2000-02-01
Abstract: Selon une de ses réalisations, cette invention se rapporte à des compositions à base de fluoropolymères réticulables, de l'onium et, en tant qu'agent de réticulation, un composé alkyle ou aryle bloqué par oxalate. Selon d'autres réalisations, l'invention se rapporte à des procédés de fabrication de compositions de fluoropolymères réticulables ainsi qu'à des composés alkyle ou aryle bloqués par oxalate.
Patent CA-2386258-A1 (CA)
Inventor: RANNEY DAVID F
IPC: C12Q1/68
Filed: 2000-10-06
Abstract: A method for detecting interactions between first and second interacting molecules at variable sensitivity. This variable sensitivity may be obtained by providing for the overexpression of either a bait hybrid protein containing a DNA binding domain (desensitization) or a prey hybrid protein containing the DNA activation domain for a reporter gene (enhanced sensitivity). The use of exogenous activators of one or the other according to the needs of a particular system is readily accomplished.
Patent CA-2387097-A1 (CA)
Inventor: KNAPCZYK STANLEY
IPC: H04L9/08
Filed: 2000-08-25
Abstract: Communication protocol for the formation and exchange of messages, including key management messages, between a KVL and one or more target devices. The protocol defines a frame format (308) and a message exchange sequence (314) that allow variable length key management messages to be routed through the KVL to the target device(s). The protocol is adapted for use in a manual or store-and-forward rekeying system and allows for encryption of the key management message(s).
Patent CA-2391765-A1 (CA)
Inventor: NISHIKAWA KENICHI
IPC: C03C8/12
Filed: 2002-06-25
Abstract: A spark plug comprising: a center electrode; a metal shell; and an alumina ceramic insulator disposed between the center electrode and the metal shell, wherein at least part of the surface of the insulator is covered with a glaze layer comprising oxides, the glaze layer comprising: 1 mol% or less of a Pb component in terms of PbO; 40 to 60 mol% of a Si component in terms of SiO2; 20 to 40 mol% of a B component in terms of B2O3; 0.5 to 25 mol% of a Zn component in terms of ZnO; 0.5 to 15 mol% in total of at least one of Ba and Sr components in terms of BaO and SrO, respectively; 2 to 12 mol% in total of at least one alkaline metal component of Na, K and Li, in terms of Na2O, K2O, and Li2O, respectively, wherein K is essential; and 0.1 to 5 mol% in total of at least one component of Bi, Sb and rare earth RE, RE being at least one selected from Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu, in terms of Bi2O3, Sb2O5 and RE2O3, respectively, proviso that Ce is in terms of CeO2 and Pr is in terms of Pr7O11, wherein the glaze layer comprises 8 to 30 mol% in total of the Zn component and the at least one of Ba and Sr components in terms of ZnO, BaO and SrO, respectively.
Patent CA-2392420-A1 (CA)
Inventor: GEIS MARK W
IPC: A47D13/02
Filed: 2002-07-04
Abstract: An infant seat (which is also known as an infant carrier) includes a shell having sidewalls and a handle having arms attached to the sidewalls. A cushion pad may be attached to an arm and partially defines an inwardly-facing surface of the arm. Preferably this cushion pad contacts the crook of an elbow of a user who is carrying the infant seat by wrapping the crook of the elbow around the first arm of the handle. Another cushion pad may be attached to either the outwardly-facing surface of the shell or the similarly-facing surface portion of the arm.  Preferably, this cushion pad contacts the hip of the user.
Patent CA-2394753-A1 (CA)
Inventor: RUBEN STEVEN M
IPC: G01N37/00
Filed: 2001-01-17
Abstract: La présente invention concerne de nouveaux polypeptides de la protéine thyrosine phosphatase humaine et des acides nucléiques isolés contenant les régions codantes des gènes codant ces polypeptides. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps, et des méthodes recombinantes destinées à produire des polypeptides de la protéine thyrosine phosphatase humaine. L'invention concerne également des méthodes diagnostiques et thérapeutiques convenant pour le diagnostic et le traitement de troubles liés à ces nouveaux polypeptides de la protéine thyrosine phosphatase humaine.
Patent CA-2395456-A1 (CA)
Title: Hydrogels
Inventor: FRANCIS VIMALA MARY
IPC: A61K35/12
Filed: 2001-01-03
Abstract: The present invention relates to a cell growth substrate polymer that is obtainable by polymerizing a polymerizable component comprising at least one  hydrophilic monomer or macromer which is devoid of a sulfo group, at least o ne sulfo-group-containing monomer, and optionally a crosslinker in a weight rat io as defined in the claims. The polymers of the invention are useful, for example, as substrates for the attachment and growth of mammalian cells and tissue and in particular as materials for the manufacture of biomedical devices and prostheses, including implanted devices.
Patent CA-2396722-A1 (CA)
Title: Formulations of active components in the form of a solid dispersion
Inventor: LIPPOLD BERNHARD C
IPC: A61K9/14
Filed: 2001-01-10
Abstract: Formulations of active compounds in the form of a solid dispersion, where the solid dispersion is formed from at least one active component and a carrier characterized in that the carrier is a mixture of polyvinylpyrrolidone (PVP) with a weight average molecular weight of <= 1 500 000 Da and of a polyethylene glycol (PEG) which is semi-solid or solid at temperatures of 17 to 22 °C and has an average molar mass of 950 to 3300 Da.
Patent CA-2401252-A1 (CA)
Inventor: MERSMANN MICHAEL
IPC: A61K47/48
Filed: 2001-03-16
Abstract: The invention relates to antibody proteins which specifically bind fibroblast activating protein alpha (FAP.alpha.). The invention further relates to the use of said antibodies for diagnostic and therapeutic purposes as well as processes for preparing said antibodies.
Patent CA-2404720-A1 (CA)
Title: Musical toothpaste tube closure
Inventor: BARNETT MICHAEL
IPC: B65D51/24
Filed: 2001-04-05
Abstract: A dentifrice closure (16) on a dentifrice tube (10) can emit a signal upon the opening of the closure (16) to dispense some of the den-tifrice.    The closure (16) is comprised of a base portion (18) to attach the closure to the dentifrice tube (10) and a lid portion (20) that closes the dis-pensing opening of the dentifrice tube (10) and which contains switch timer (28) and signal generator. The signal generator can be a light, but preferably is a sound generator, and most preferably a music generator. Upon the lid (20) being opened, a switch (28) activates the timer which in turn activates the signal generator. Regardless of the position of the switch (28) after a lid (20) opening (the lid can be quickly closed) the signal will be emitted for a set period of time.
Patent CA-2405708-A1 (CA)
Inventor: DA COSTA E SILVA OSWALDO
IPC: C12N15/54
Filed: 2001-04-06
Abstract: Cette invention a trait à une plante transgénique transformée par une protéine de fixation de la GTP liée au stress (GBSRP) codant un acide nucléique. L'expression de la séquence nucléotidique dans la plante entraîne chez celle-ci une tolérance accrue au stress environnemental et ce, par rapport à celle de la même plante, mais de type sauvage. L'invention concerne également des produits agricoles, notamment des graines, obtenus grâce à ces plantes transgéniques. Elle porte, de surcroît, sur des GBSRP isolées, sur des acides nucléiques isolés codant des GBSRP ainsi que sur des vecteurs et des cellules hôtes les contenant.
Patent CA-2406083-A1 (CA)
Inventor: WARDLEY MIKE
IPC: B05B1/00
Filed: 2001-04-02
Abstract: A drill bit nozzle (1) providing a through bore for the passage of drilling fluid through a drill bit. The nozzle (1) is made of a material or materials which can be drilled through by standard well bore drilling equipment. The material(s) are selected to provide a surface (5) to the through bore which has a relatively high resistance to erosion to withstand the abrasive and corrosive impact of jetted drilling fluid. Embodiments are described using a hard chrome/copper combination and a single rubber material.
Patent CA-2406975-A1 (CA)
Title: Infusion sleeve for ophthalmic surgery
Inventor: ZALESKI EDWARD R
IPC: A61M1/00
Filed: 2001-04-16
Abstract: Sleeve apparatus for a phacoemulsification/irrigation and aspiration handpie ce includes an elongate sleeve having a proximal and a distal end with a sleeve  establishing an annular passage around a needle enabling irrigation fluid to  pass into the eye through the passage and into the eye while cooling the needle. The elongate sleeve includes a hub disposed a proximal end for enabling attachment of the sleeve to the handpiece and a port disposed approximate the distal end and in fluid communication with the annular passa ge is provided for introducing irrigation fluid into the eye. An internal circumferential berm, disposed between the port and the distal end is provid ed to reduce flow of the irrigation fluid therepast, to provide rigidity to the  distal end of the sleeve and concomitantly provide limited contact with the needle in order to produce thermal transfer therebetween.
Patent CA-2407688-A1 (CA)
Title: Method of distributing printed advertising
Inventor: GROSSMAN JAMES
IPC: G06Q30/02
Filed: 2001-04-26
Abstract: A distribution of printable paper sheets (10) with advertisements pre-printed or embedded thereon through conventional retail channels. Alternatively, a printable paper sheet printed with ads is downloaded from the Internet (50) for general use by any interested party. The user can register with a sponsor/intermediary to receive such general or specific advertising from his/her computer related printing device (20). As consideration, the user receives credits or points based, e.g., on the number of pages or ads printed.  Alternatively, a computer-directed printer is modified, e.g. by connecting a programmable IC or equivalent means to its control circuit to add ads to a predetermined printable fields on the printable paper sheets passing though the printer (20). Alternatively, the IC device can be installed in the computer's CPU or printer to control the printer's operation.Predetermined or random areas of the paper sheets are thereby allocated to receive printed ads, leaving printable field constituting the rest of the sheet to receive printed information downloaded from the Internet, or otherwise created by the user.
Patent CA-2407700-A1 (CA)
Title: Compositions and methods for inducing activation of dendritic cells
Inventor: KABANOV ALEXANDER V
IPC: A61K9/08
Filed: 2001-04-30
Abstract: Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives there of and at least one block copolymer of alkylethers. The present invention furth er relates to compositions for inducing the activation of dendritic cells where in the block copolymers are PLURONIC F127 and L61. More particularly, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention.  Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.
Patent CA-2408183-A1 (CA)
Title: Inspection system for edges of glass
Inventor: WEISS ADAM
IPC: G01N21/896
Filed: 2000-06-23
Abstract: An inspection system for the edge of a sheet of glass e.g. automobile glass.  The system has at least one laser, with the laser beam directed at the edge of the glass. Light reflected from the edge is recorded e.g. with a camera. The path length from the laser to the glass edge and back to the camera is maintained constant as the glass moves through the apparatus.
Patent CA-2409107-A1 (CA)
Inventor: MCCORDIC CRAIG H
IPC: H01L35/00
Filed: 2001-05-17
Abstract: A thermoelectric dehumidifier (100) includes at least one thermoelectric chiller element (102) disposed within a sealed cavity (104) defined between hot and cold plates (106, 108) for removing moisture from an enclosure. The thermoelectric dehumidifier (100) can include a gutter (112, 112') for receiving condensate from the coldplate (108) surface. A drainage mechanism (116) can be coupled to the gutter (112, 112') for removing the collected condensate from the enclosure. An antenna array enclosure can include a thermoelectric dehumidifier (100) that passively reduces the relative humidity within the array enclosure.
Patent CA-2409578-A1 (CA)
Inventor: OHLER CHRISTIAN
IPC: H01G4/008
Filed: 2002-10-22
Abstract: Film capacitors have a thin carrier film (1) as dielectric. The surfaces of the carrier films are provided with conductor layers (2) - serving as electrodes - made of metal or made of a nonmetallic conductor. It the capacitor is charged during operation, electric fields with large field strengths can arise at the edges of the conductor layers (2), which can lead to breakdowns. The invention is essentially distinguished by the fact that an edge zone coating (3) is present at the edges of the electrode-forming conductor layer (2), which edge zone coating is only partly charged in the time periods - for example of the alternating-current period - which are critical for changes in the applied voltage. To that end, the edge zone coating of the film must have a surface conductivity which is less than the surface conductivity of the conductor layer. The only partial charging of the edge zone coating has the result that the potential profile has scarcely any discontinuities and large field strength increases can thus be avoided.
Patent CA-2411718-A1 (CA)
Inventor: DE LAFORCADE VINCENT
IPC: G01F11/26
Filed: 2002-11-15
Abstract: The container (10) has the form of a cylindrical can divided into a lower storage section (A) for the liquid (P) and an upper retention section (B) with a dosing cavity (21). The retention element (20) comprises supports (24) and an elastic membrane (22). On inversion of the can liquid flows past the membrane periphery to enter the retention section and on return to normal drains through a tube (30) to give a measured dose for pumping (70)
Patent CA-2414689-A1 (CA)
Title: Banknote loader
Inventor: BUKHMAN SERGIY
IPC: G07D11/00
Filed: 2002-12-18
Abstract: A method of loading banknotes to a banknote validator and dispenser system replaces the existing validator with a combination loader and validator. A stack of banknotes has been preloaded in the loader and are not accessible to the service technician. The loader is inserted into the system in place of the removed validator and forms an electrical connection with the system. Banknotes are fed from the loader and directed by the system to the appropriate accumulator and stored therein for later dispensing. The validator of the loader can be of high speed to reduce the loading time.      Access to the stack of banknotes and access to banknotes stored in the accumulators is restricted and secure.
Patent CA-2420465-A1 (CA)
Title: Polymeres de polypropylene
Inventor: CHIEN SUSAN C
IPC: C08F4/659
Filed: 2001-08-22
Abstract: Les réalisations de l'invention concernent un homopolymère de polypropylène synthétisé à partir d'un système de catalyseur métallocène ainsi que des procédés de formation de l'homopolymère, cet homopolymère présentant un entraînement en cuivre et en chlore à des teneurs inférieures à 25 ppm et une proportion de solubles dans le xylène inférieure à 1 % en poids par rapport au poids total de l'homopolymère. L'homopolymère résultant possède d'autres propriétés recherchées telles que la température de déformation à la chaleur à 0,45 MPa comprise entre 90 ·C et 110 ·C, et un indice de polydispersité compris entre 1,7 et 5Ø Ces propriétés font que les réalisations concernant cet homopolymère sont souhaitables pour la réalisation de film, en particulier de films pour condensateurs.