baber/WOPTO huggingface dataset:
Patent CN-100550288-C (CN)
Title: 形成半导体器件的精细图案的方法
Inventor: CHANG JUNG JAE
IPC: H01L21/768
Filed: 2007-02-16
Granted: 2009-10-14
Abstract: 本发明公开一种用于形成半导体器件的精细图案的方法，该方法包括以下步骤：在形成于半导体基板之上的底层上，形成宽度为W1、厚度为T1的第一硬掩模图案；在所得结构上形成平坦型的第二硬掩模薄膜，并且使所述第二硬掩模薄膜平坦化，以露出所述第一硬掩模图案；将所述第一硬掩模图案从顶面除去T2(0＜T2＜T1)厚度；在所述第二硬掩模薄膜上进行修蚀工序，以形成具有倾斜侧壁的第二硬掩模图案；在所述第二硬掩模图案上进行第二修蚀工序，以将所述第二硬掩模图案和所述第一硬掩模图案分开，并且形成宽度为W2的第三硬掩模图案；以及使用所述第一硬掩模图案和所述第三硬掩模图案作为蚀刻掩模，对所述底层进行图案化。
Patent CN-100533013-C (CN)
IPC: F25D17/06
Filed: 2007-05-15
Granted: 2009-08-26
Abstract: 公开一种用于冰箱的冷空气供应设备。该冷空气供应设备包括：冷冻室蒸发器，该冷冻室蒸发器产生供应到冷冻室的冷空气；冷藏室蒸发器，该冷藏室蒸发器产生供应到冷藏室的冷空气；冷冻室横流风扇，该冷冻室横流风扇朝着冷冻室吹动由冷冻室蒸发器产生的冷空气；冷藏室横流风扇，该冷藏室横流风扇吹动由冷藏室蒸发器产生的冷空气；和驱动马达，该驱动马达驱动冷冻室横流风扇和冷藏室横流风扇。采用该结构，被引入蒸发器中的冷空气大致均匀，从而提高热交换效率。
Patent CN-100533343-C (CN)
Inventor: MICHAEL BRADICICH THOMAS
IPC: G05B23/02
Filed: 2007-05-22
Granted: 2009-08-26
Abstract: 本发明公开一种检测机柜服务器系统内的再循环的系统和方法。为机柜服务器系统构造热传导模型。指定再循环区，并且输入再循环区处的假设再循环温度。热传导模型预测机柜服务器系统中其它位置的温度，并且计算预测温度曲线。感测机柜服务器系统中的实际温度，并且也产生实际温度曲线。将实际温度曲线与预测温度曲线比较以检测可能的再循环。
Patent CN-100589396-C (CN)
Inventor: WEIDONG JING
IPC: H04L12/14
Filed: 2007-11-20
Granted: 2010-02-10
Abstract: 本发明公开一种预付费业务的前转计费控制方法，该方法包括：配置被叫业务逻辑处理(MT)流程的资费费率等于扣费费率，前转业务逻辑处理(MF)流程的资费费率等于MT流程扣费费率与MF流程扣费费率之和；登记有条件前转业务的预付费用户被呼叫，且满足其呼叫转移条件的情况下，分别触发MT流程和MF流程对预付费用户作为被叫用户和前转用户的通话过程进行控制及扣费。本发明的预付费业务有条件前转计费方法，在MT流程和MF流程中，设置资费费率和扣费费率两种费率，以资费费率有效地限制预付费用户的通话时间，通话结束后，按照扣费费率对预付费用户帐户进行扣费，既保证了运营商的运营利益，又不会给预付费用户带来诸多不便。
Patent FR-90152-E (FR)
Inventor: DAWANS FRANCOIS
IPC: C08F136/06
Filed: 1965-07-03
Granted: 1967-10-27
Abstract: 1,132,437. Polymerisation catalyst. INSTITUT FRANCAIS DU PETROLE, DES CARBURANTS ET LUBRIFIANTS. 18 Feb., 1966 [18 Feb., 1965; 3 July, 1965], No. 7289/66. Heading B1E. [Also in Division C3] A catalyst comprises a compound of a metal of Gps. IV to VIII and a co-ordination complex of nickel and a cyclo-poly-olefin having a ring containing at least 6 atoms of carbon. Said compound is preferably a halide e.g. chloride of a metal of Groups IVa, Va or VIa. Examples of said compound are TiCl 4 , TiCl 3 , TiBr 4 , Til 4 , TiF 4 , ZrCl 4 , VCl 4 , MoCl 5 , FeCl 3 , NiCl 2 , SnCl 4  and SbCy 5 . Examples of the nickel complex are given.
Patent PT-1044822-E (PT)
Inventor: SCHULZ HARTMUT
IPC: B41M5/52
Filed: 2000-04-01
Abstract: A decorative paper (I) for the decorative coating of materials, contains an ink absorbent layer.
Patent PT-1052212-E (PT)
Inventor: ROLF MUELLER
IPC: B66B/
Filed: 2000-05-04
Abstract: The lift arrangement has a counter weight and a lift cabin (2) that can be moved with a maintenance platform (10). The roof the lift cabin serves as the maintenance platform. A maintenance operation safety device (13) ensures a specified distance (U) between the cabin roof (2.1) and the shaft ceiling (1.2) for the safety of the maintenance personnel and secures the lift cabin against any further u(upward movement.
Patent PT-1174138-E (PT)
Title: Use of mometasone furoate for treating airway passage and lung diseases
Inventor: CHAUDRY IMTIAZ A
IPC: A61P37/00
Filed: 1995-01-26
Abstract: Mometasone furoate is used in manufacture of a metered dose inhaler formulation for treatment of asthma, disease ofthe upper or lower airway passages, allergic or non-allergic rhinitis and allergic and/or inflammatory diseases of the lower airway passages and/or lungs.
Patent PT-1268036-E (PT)
Title: Method and apparatus for separating particles from hot gases
Inventor: HYPPAENEN TIMO
IPC: B01J19/00
Filed: 2001-04-06
Abstract: Method and apparatus for separating solid particles from gas exhausted from the reaction chamber of a fluidized bed reactor, the separator apparatus comprising a vortex chamber which is in horizontal direction defined by vertically-extending outer walls formed of planar water tube panels, the inside of the walls being at least partly provided with a refractory lining and defining a gas space in the vortex chamber, where at least one vertical gas vortex is established, at least one gas inlet, at least one gas outlet; and at least one solids outlet, in which apparatus the vertically-extending outer walls of the vortex chamber form at least one comer, the angle between the sides of which exceeds 90 degrees, the comer being rounded by a refractory lining on the inside of the outer walls. <IMAGE>
Patent PT-1278534-E (PT)
Title: Methods and compositions for impairing multiplication of hiv-1
Inventor: GOLDSTEIN GIDEON
IPC: A61K38/08
Filed: 2001-04-20
Abstract: A composition which elicits antibodies to multiple known variants of Tat protein of HIV-1 of both the B and non-B clades contains the peptide R1-Asp-Pro-Asn-Leu-Asp-Pro-Trp-Asn-R2 SEQ ID NO: 23, and preferably an additional at least two variants of a peptide or polypeptide of the formula: R1-Asp-Pro-Y<SUB>7</SUB>-Leu-X<SUB>9</SUB>-Pro-Trp-Z<SUB>12</SUB>-R2 (SEQ ID NO: 8). In this composition, at least one of the two variants contains Arg at Y<SUB>7 </SUB>and Lys at Z<SUB>12</SUB>, and in at least a second of the two variants Y<SUB>7 </SUB>is Asn and Z<SUB>12 </SUB>is Asn. Vaccinal and pharmaceutical compositions can contain one or more such peptides associated with carrier proteins, associated in multiple antigenic peptides or as part of recombinant proteins. Diagnostic compositions and uses are described for assessing the immune status of vaccinated patients.
Patent PT-1309607-E (PT)
Inventor: ENGEL JUERGEN
IPC: A61K/
Filed: 2001-08-09
Abstract: A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.
Patent PT-1419623-E (PT)
Inventor: RAJI FARIBA
IPC: H04L12/56
Filed: 2002-08-19
Abstract: Data packets of a data flow are identified for transmission in a radio communication system with a data flow and/or individual service indicator enabling them to be allocated to the corresponding data flow for reception. A sequence number for the data packets in each data flow is added upon transmission to the data packet in order to reestablish the original order of the data packets of a data flow; the advantage thereof being that the data flows of several services can use a common HARQ process, whereupon the memory used for reception according to said HARQ process can be reduced.
Patent PT-1501106-E (PT)
Title: Ferrite core for inductive element
Inventor: GULDEN CHRISTOF
IPC: H01F3/14
Filed: 2003-07-23
Abstract: Ferrite core comprises parallel sides (1, 2) joined at their ends by yokes (3, 4) and having segments (5) separated from each other by an insulator (6). An independent claim is also included for an inductance component.
Patent PT-1540083-E (PT)
Title: Method of reinforcing and waterproofing a paved surface
Inventor: HELWIG GREGORY S
IPC: E01C7/18
Filed: 2003-06-20
Abstract: In a method of reinforcing and waterproofing a paved surface, a layer of liquefied asphalt is applied on a paved surface. A reinforcement mat is then applied over the liquefied asphalt. The reinforcement mat includes a first layer comprising a nonwoven mat produced from fibers selected from the group consisting of mineral fibers, polymer fibers, and mixtures thereof. The reinforcement mat also includes a second layer of mineral fibers attached to the first layer. The liquefied asphalt penetrates and soaks the reinforcement mat to form a water barrier. A layer of paving material is then applied a over the reinforcement mat. The first layer and the second layer of the reinforcement mat are attached to each other by any one of sewing, knitting, needling, heat treating, and adhering with an adhesive, or combinations thereof.
Patent PT-1549650-E (PT)
Inventor: HENNIES HAGEN-HEINRICH
IPC: A61P25/00
Filed: 2003-10-06
Abstract: Substituted C-(imidazo-(1,2-a)-pyridin-3-yl)-methylamines (I) are new.  Imidazo-pyridine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions and in acid, base, salt or solvate (specifically hydrate) form, are new.  R1 = OH, SH, NH2, NHMe, NMe2, Me, CH2Cl, CH2F, CHF2, CF3, OMe, OCH2Cl, OCH2F, OCHF2, OCF3, Et, CHClMe, CH2CH2Cl, CHFMe, CH2CH2F, CH2CHF2, CH2CF3, OEt, COOH, CH2OH, CH(OH)Me, CH2CH2OH, CN or halo; R2 = H or Me; R3 = H or COOR10; or (all optionally substituted) optionally unsaturated 1-6C alkyl, optionally unsaturated 3-8C cycloalkyl, 2-methylcyclopropyl, cyclopropylmethyl, 2- or 3-methylcyclobutyl, cyclobutylmethyl, aryl or heteroaryl; R4 = H or heterocyclic group of formula (a); or (all optionally substituted) optionally unsaturated 1-12C alkyl, optionally unsaturated 3-8C cycloalkyl, 2-methylcyclopropyl, cyclopropylmethyl, 2- or 3-methylcyclobutyl or cyclobutylmethyl; n, m = 0-6, provided that n + m = 1-6; X = O, S, SO, SO2 or NR7; R = H, halo, OH, SH, NH2, NO2, Me, Et, OMe, OEt or OCF3; R5 = H; or (all optionally substituted) optionally unsaturated 1-6C alkyl, optionally unsaturated 3-8C cycloalkyl, 2-methylcyclopropyl, cyclopropylmethyl, 2- or 3-methylcyclobutyl or cyclobutylmethyl; R6 = H or R14-unsubstituted 2-pyridinyl; or (all optionally substituted) optionally unsaturated 1-6C alkyl, optionally unsaturated 3-8C cycloalkyl, 2-methylcyclopropyl, cyclopropylmethyl, 2- or 3-methylcyclobutyl or cyclobutylmethyl; or NR5R6 = morpholino, 4-(R11)-piperazino, azetidino, pyrrolidino, piperidino or homopiperidino; R7 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-methylcyclopropyl, cyclopropylmethyl, 2- or 3-methylcyclobutyl, cyclobutylmethyl, COR8 or SO2R9; R8 - R10 = H, 1-6C alkyl or aryl; R11 = H, 1-6C alkyl, 3-8C cycloalkyl, aryl, heteroaryl, aryl-(1-3C) alkyl, heteroaryl-(1-3C) alkyl, COR12 or SO2R13; R12, R13 = H, 1-6C alkyl or aryl; and R14 = H, halo, OH, SH, NH2, NO2, Me, Et, OMe, OEt or OCF3. Provided that the compounds (7-methyl-imidazo-(1,2-a)-pyridin-3-ylmethyl)-dimethylamine and C-(7-methyl-imidazo-(1,2-a)-pyridin-3-yl)-methylamine are excluded.
Patent PT-1561940-E (PT)
Title: Gas exhaust recirculation assisted fuel injection system
Inventor: WIATRAK WIESLAW
IPC: F02M25/07
Filed: 2004-09-22
Abstract: A supportive system of fuel injection with recirculation of exhaust gas for a combustion engine with an even number of cylinders, based on a special control of exhaust gas recirculation using a recirculation valve with a preliminary fuel injection chamber, using a typical fuel injector.  An exhaust gas recirculation valve, inbuilt between cylinders and synchronically controlled with rotary motion of the engine crankshaft, enables blow-by of a fuel dose, using the energy of recirculated exhaust gas, through the exhaust gas recirculation valve to the combustion chamber of the cylinder being in its compression cycle, which enhances fuel evaporation and causes micro and macro turbulences of the load, facilitating its combustion process, which results in improvement of the efficiency of an internal combustion engine.
Patent PT-1587926-E (PT)
Title: Lipophilic derivatives of double-stranded ribonucleic acid
Inventor: LIMMER STEFAN
IPC: A61P31/14
Filed: 2004-01-21
Abstract: Double-stranded RNA (I) having a strand (S1) that is complementary, at least in parts, to a target gene (TG) and, the new feature, linked to at least one lipophilic group (A) is new.  An Independent claim is also included for a method for producing (I) by solid-phase synthesis, in the 3' to 5' direction, of S1 and/or S2, that uses in the last synthesis cycle a lipophilic molecule that contains a phosphoramidite group.
Patent PT-1686997-E (PT)
Title: Inhibitors of the mutant form of kit
Inventor: BUCHDUNGER ELISABETH
IPC: A61P35/00
Filed: 2004-11-17
Abstract: The present invention relates to the treatment of KIT dependent diseases that are characterized by a mutant form of KIT whereby the mutant KIT is identified and an appropriate inhibitor of the mutant KIT is administered.
Patent PT-1591716-E (PT)
Title: Semi-built-in lighting apparatus with concentrated beam
Inventor: GUZZINI GIANNUNZIO
IPC: F21Y101/00
Filed: 2005-04-26
Abstract: A semi-built-in lighting apparatus with concentrated beam (10) comprising a containment body or outer casing (13), which is housed in an opening (12) of a false ceiling (11), a bulb socket unit (14), with respective reflector (27), and an outer filling ring (16), in which apparatus the outer filling ring (16) foresees an inner seat (31) for housing at least one glass insert (32) and freely removable fastening means (19, 20) to the containment body or outer casing (13), a central cylindrical element (28, 29) with a limited diameter carrying at least one transparent piece of glass (36, 37) and being fixed in a central hole (33) of said at least one glass insert (32).
Patent PT-1735772-E (PT)
Title: Ergonometric classical guitar
Inventor: BOUTE CHRISTIAN
IPC: G10D1/08
Filed: 2005-03-25
Abstract: The sound box includes two truncated portions ( 1 and 4 ) for enabling the body to take up a better position in order to avoid certain pathologies induced by playing the instrument as it currently exists.
Patent PT-1715340-E (PT)
Title: Method and apparatus for preparing tissue specimens for parallel analysis
Inventor: KONONEN JUHA
IPC: C12M1/00
Filed: 1999-02-24
Abstract: An array-based technology facilitates rapid correlated gene copy number and expression profiling of a very large numbers of human tumors. Hundreds of cylindrical tissue biopsies (diameter 0.6 mm) from morphologically representative regions of individual tumors can be arrayed in a single paraffin block. Consecutive sections from such arrays provide targets for parallel in situ visualization and quantitation of DNA, RNA or protein targets. For example, amplifications of six loci (mybL2, erbB2, Cyelin-D1, riryc, 17q23 and 20q13) were rapidly determined by fluorescence in situ hybridization from 372 ethanol-fixed breast cancers. Stratifcation of tumors by estrogen receptor and p53 expression data revealed distinct patterns of gene amplification in the various subgroups of breast cancer that may have prognostic utility. The tissue array technology is useful in the rapid molecular profiling of hundreds of normal and pathological tissue specimens or cultured cells.
Patent PT-1877234-E (PT)
Title: Load carrying apparatus and method of manufacture
Inventor: RIMMER TIMOTHY
IPC: B29C41/22
Filed: 2006-04-26
Abstract: A polymeric load carrying apparatus (10) and method of manufacture is disclosed. The apparatus comprises an outer shell composition and a filled inner core composition within the outer shell composition. The outer shell composition comprises less than 10% filler, and preferably substantially no filler, by weight, and the inner core composition comprises more than 15% filler, and preferably at least 40% filler, by weight. The filler is preferably a mineral sand.
Patent PT-1928503-E (PT)
Title: Process for preparing maytansinoid antibody conjugates
Inventor: DAI YONG
IPC: A61K47/48
Filed: 2006-08-14
Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
Patent PT-2061582-E (PT)
Title: Method and installation for bringing ozone into contact with a flow of liquid, in particular a flow of drinking water or wastewater
Inventor: LIECHTI PIERRE-ANDRE
IPC: B01F3/04
Filed: 2007-09-05
Abstract: Method for bringing ozone into contact with a flow of liquid in which a fraction of the liquid flow is tapped off, a carrier gas laden with ozone is injected into the tapped-off flow, forming gas bubbles, the gas bubbles and the liquid are mixed so as to form a two-phase tapped-off flow, and the tapped-off flow is reintroduced into a descending vertical stream of the main liquid flow, this vertical stream undergoing, at the bottom, a change of direction to essentially the horizontal, the reintroduction of the tapped-off flow being carried out at the lower end of an injection tube immersed in the descending vertical stream of the main flow. The descending vertical stream (3a) forms a continuous liquid column, static mixing is provided in the injection tube (16) as far as the vicinity of its outlet, and the two-phase tapped-off flow is reintroduced into the descending vertical stream (3a) in the form of at least one jet having a vertically downward velocity component, this reintroduction taking place below a height (H) of liquid and with a vertically downward velocity component that are sufficient for the gas bubbles to be entrained downwards, without rising.
Patent PT-2094653-E (PT)
Title: O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists
Inventor: BARALDI PIER GIOVANNI
IPC: A61K31/17
Filed: 2007-12-06
Abstract: The invention relates to compounds of formula (I)   
wherein 
R is halogen; 
R 1  is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl, aminomethyl, 2-aminoethyl, 3-aminopropyl, 3-amino-2-hydroxypropyl, 1,3-dioxolane-ethyl, 1,3-dioxane-methyl, 1,3-dioxolane-methyl, 1,3-dioxane-ethyl, 3-fluoro-2-hydroxypropyl, 3-chloro-2-hydroxypropyl, 2-hydroxypropyl, 2-hydroxypropen-2-yl, morpholinoethyl, piperazinoethyl, hydroxymethyl, benzyl, 4-(hydroxymethyl)benzyl, 4-chlorobenzyl, 4-fluorobenzyl, 4-hydroxybenzyl, and 4-aminobenzyl; 
R 2  is O or S; 
R 3  is tert-butyl or trifluoromethyl; 
n is an integer selected from 0, 1 or 2.  The compounds of formula (I) can be used for the preparation of pharmaceutical compositions for the therapy of inflammatory states, such as chronic neuropathic pain, over-active bladder syndrome, tumor pain, haemorrhoids, inflammatory hyperalgesia, post-intervention pain, dental extraction, airway and gastro-intestinal diseases.
Patent PT-2166697-E (PT)
Title: Method and system for authenticating a user by means of a mobile device
Inventor: COBOS JUAN JESUS LEON
IPC: H04L9/32
Filed: 2008-09-17
Abstract: The invention relates to a method for authenticating a user of a mobile device (10) against a remote authenticating system (30) which is connected to a client computer accessible to said user, which comprises: 
i- reading a 2D-code displayed to the client computer (40) by means of a 2D-code reader provided in said mobile device, a URL address of the authenticating system and a codified challenge generated by authenticating system being embedded in said 2D-code; 
ii- processing said codified challenge and computing a response to it using a personal secret, which is a string of characters univocally related to a user identifier (user ID) of said user of the mobile device and to a time stamp; 
iii- sending a message to the authenticating system which includes a tuple (100) whose elements are said user ID, the challenge and its response; 
iv- analyzing the tuple elements and determining the tuple is valid if the response to the challenge has been generated using the personal secret of the user whose user identifier is in the tuple for a given period of time, and in case said tuple is valid: 
v- checking in a users list (300) in the authenticating system if the user identifier in the tuple is in said users list, and if the user identifier is in the users list, it is verified if the challenge in the tuple is in a session list in the authenticating system, and if the challenge is in the session list, the authenticating system pushes a welcome screen to the client computer that corresponds to a session identification number in the session list where the challenge is.  The invention also to a system for authenticating a user of a mobile device.
Patent PT-2187097-E (PT)
Title: Linear drive
Inventor: STAUB PATRICK
IPC: F16H25/20
Filed: 2008-11-14
Abstract: The linear drive comprises a spindle (1) with a threaded section (12) having a central axis (M), where a spindle nut (4) is engaged with the threaded section. The spindle is connected with a bearing point (6) by an axial bearing formed for transmission of axial forces from the spindle to the bearing point. A gearbox (7) comprises an output shaft (71) which is supported on the spindle. An independent claim is included for a device with a worm gear which is transferred on the spindle.
Patent PT-2070595-E (PT)
Title: Device for dimensional reduction by grinding, crushing, shredding or nibbling of manufactured products or materials of considerable size
Inventor: BECKER ARNAUD
IPC: B02C4/28
Filed: 2008-12-11
Abstract: The device has a three dimensional reduction unit (3) formed of a driving motor (300), and an introduction ramp (1) equipped with a compression unit (2). A chassis (4) supports an assembly of the device, and a protection cover covers the assembly. The encumbrance of the reduction unit is small with respect to a section of the introduction ramp. The ramp and/or the reduction unit are displaced with respect to each other by a driving unit.
Patent PT-2125099-E (PT)
Title: A miniaturized injection device for medical use
Inventor: PERRIERE BERNARD
IPC: A61M37/00
Filed: 2008-02-18
Abstract: The miniaturized injection device (1) for medical use comprises a tube (2) extending along a certain axis (A-A) and in which there is disposed at least one reservoir (12) for receiving a medicinal substance, the reservoir being connected to at least one needle (14). The needle is movable in the tube (2) along said axis (A-A) and the injection device (1) further includes a pump (13) interposed between the needle and the reservoir. The pump is controlled by a switch (21) that operates in response to the needle (14) moving in the tube along said axis (A-A).
Patent PT-2148670-E (PT)
Title: Titration of tapentadol
Inventor: ROMBOUT FERDINAND
IPC: A61K31/137
Filed: 2008-04-21
Abstract: The invention relates to the use of tapentadol for the manufacture of a medicament comprising at least one administration unitAcontaining doseaof tapentadol and at least one administration unitBcontaining dosebof tapentadol, where dosea< doseb, for the treatment of pain.
Patent PT-579496-E (PT)
Inventor: LEE SUNG JAI
IPC: C07D401/04
Filed: 1993-07-15
Abstract: The compounds of the formula: <CHEM>  wherein R<1> is H or alkyl;  Y is bond or alkylene;  A is     (i) -CyA-(R<2>)l,   (ii) -O-R<0> or -S(O)p-R<0> or   (iii) -NR<1><6>R<1><7>;  CyA is     (1) 3-7 membered monocyclic carbocyclic ring, (2) 4-7 membered monocyclic hetero ring containing as hetero atoms, one N atom, one N and one O atoms, two N and one O atoms, or one N and two O atoms, (3) 4-7 membered monocyclic hetero ring containing as hetero atoms, 1 or 2 O or S atoms; R<2> is (1) H, (2) alkyl, (3) alkoxy, (4) -COOR<5>, in which R<5> is H or alkyl, (5) -NR<6>R<7>, (6) -SO2NR<6>R<7>, (7) halogen, (8) CF3, (9) NO2 or (10) CF3O;  Z is bond, methylene, ethylene, vinylene or ethynylene;  R<3> is H, alkyl, alkoxy, halogen or CF3; and acid addition salts thereof, salts thereof, and hydrates thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA2 synthetase.
Patent PT-684842-E (PT)
Inventor: KLATZMANN DAVID
IPC: A61K35/12
Filed: 1994-02-21
Abstract: Compsn. for treating tumours in humans and animals (and for immunising against tumours) comprises a synergistic combination of (1) cells, viruses or bacteria that express, transiently in the organism, at least one gene for an immunomodulator and (2) viruses (or cells producing them) that preferentially infect dividing cells in the treated organism and carry in their genome at least one gene expression of which can be lethal to such cells. Partic. the cells expressing immunomodulator and producing virus are the same. In a modification, component (1) can be replaced by any other system for delivering immunomodulator, e.g. a micropump.