Patent SG-11201903382S-A (SG)
Title: Anti-microbial supramolecular structures
Inventor: STUPP SAMUEL I
IPC: A61K38/02
Filed: 2017-10-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 01111H111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/075885 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: Evanston, Illinois 60208 (US). CHO, Nam-Joon; c/o A61K 9/00 (2006.01) C07K 2/00 (2006.01) Nanyang Technological University, 50 Nanyang Avenue, A61K 38/00 (2006.01) C07K 5/00 (2006.01) Singapore 639798 (SG). JACKMAN, Joshua A.; c/o A61K 38/02 (2006.01) Nanyang Technological University, 50 Nanyang Avenue, (21) International Application Number: Singapore 639798 (SG). PCT/US2017/057580 (74) Agent: STAPLE, David W.; 2275 Deming Way, Suite 310, Middleton, Wisconsin 53562 (US). (22) International Filing Date: 20 October 2017 (20.10.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/410,902 21 October 2016 (21.10.2016) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicants: NORTHWESTERN UNIVERSITY MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [US/US]; 633 Clark Street, Evanston, Illinois 60208 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (US). NANYANG TECHNOLOGICAL UNIVERSITY SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, [SG/SG]; 50 Nanyang Avenue, Singapore 639798 (SG). TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: STUPP, Samuel I.; c/o Northwestern Uni- (84) Designated States (unless otherwise indicated, for every versity, 633 Clark Street, Evanston, Illinois 60208 (US). kind of regional protection available): ARIPO (BW, GH, YU, Zhilin; c/o Northwestern University, 633 Clark Street, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = Title: ANTI-MICROBIAL SUPRAMOLECULAR STRUCTURES (54) = FIG. 1A _ = = — \ 0 OH 0 OH 0 H = = N OH Ci5H31 H 0 1 0 0 PA Z1 = HO 0 0 OH 0 OH = = = 0 0151131 OH H O H O= H 0 E - H 0 j H 0 = PA Z2 HO 0 F F 0 OH 0 OH 11 ir) 0 Y 0 0 H u trs'TIN''.:\"'N OH 015H31)L H .F. 0 H 0 H o = H 0 GA PA Z3 pc ir) HO 0 IN © . --- - GC (57) : Supramolecular structures comprising noncovalently associated peptide amphiphiles and lipids are provided. In partic- I l ular, provided herein are supramolecular nanostructures of peptide amphiphiles and lipids, co-assembly of which is driven by anion-n 0 interactions, and methods of preparation and use (e.g., as an antimicrobial agent) thereof. ei o [Continued on next page] WO 2018/075885 Al MIDEDIMOMOIDEIREIDIONOMEHMODEVOIMIE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))