baber/WOPTO huggingface dataset:
Patent DE-69227041-T2 (DE)
Inventor: REZAIE ALIREZA
IPC: C07K14/745
Filed: 1992-12-29
Granted: 1999-04-08
Abstract: A method is disclosed to make any protein in a form that can be isolated rapidly from a solution using a specific monoclonal antibody designated "HPC-4". It has now been determined that it is possible to form a fusion protein of the epitope with a protein to be isolated, and isolate the protein using HPC-4-based affinity chromatography. In the preferred embodiment, a specific protease cleavage site is inserted between the epitope and the protein so that the epitope can be easily removed from the isolated protein. In an example, a functionally active soluble tissue factor including the twelve amino acid epitope recognized in combination with calcium by HPC-4 and a factor Xa cleavage site was expressed from a vector inserted into a procaryotic expression system. The recombinant tissue factor can be rapidly isolated in a single chromatographic step using the HPC-4 monoclonal antibody immobilized on a suitable substrate. Once isolated, the Protein C epitope is removed by cleavage with factor Xa, leaving the functionally active, soluble tissue factor.
Patent DE-69301457-T2 (DE)
Inventor: WEIBEL RENE
IPC: F24F8/30
Filed: 1993-04-28
Granted: 1996-07-18
Abstract: PCT No. PCT/NL93/00089 Sec. 371 Date Oct. 28, 1994 Sec. 102(e) Date Oct. 28, 1994 PCT Filed Apr. 28, 1993 PCT Pub. No. WO93/22603 PCT Pub. Date Nov. 11, 1993A method and system for disinfecting air in ventilation ducts, using a non-poisonous and substantially non-volatile disinfectant. The disinfectant is vaporized by micro-vaporizer, and ionization electrodes ionize the air and the disinfectant particles. An ozone sensor is located downstream of the ionization electrodes and emits a signal to a controller, which controls the voltage at the ionization electrode, and thus the production of ozone is controlled.
Patent DE-69309086-T2 (DE)
Inventor: DENIS JEAN-NOEL
IPC: C07C271/16
Filed: 1993-10-04
Granted: 1997-09-25
Abstract: PCT No. PCT/FR93/00966 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07847 PCT Pub. Date Apr. 14, 1994This invention relates to a method of stereoselective preparation of a derivative of  beta -phenylisoserine of formula (I) by the action of an N-carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R1-O, Ar is an optionally substituted aryl radical and G1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties.    <IMAGE>  (I)  ArCHNCOR (II)   <IMAGE>  (III)
Patent DE-69309341-T2 (DE)
Inventor: PHILLIPS BRYNLEY MORRIS
IPC: C07C211/62
Filed: 1993-05-10
Granted: 1997-08-07
Abstract: A method for the manufacture of N,N dialkylglycamine compounds of general formula R2NR1R3(I) by reacting a secondary amine of general formula R2NHR3 (II) in which R2 is a straight or branched chain alkyl or hydroxyalkyl group having from 1 to 4 carbon atoms and R3 is a residue from a monosaccharide, with an alkali metal or alkaline earth metal aliphatic sulphate, R1SO4M, in which R1 is a straight or branched chain alkyl or alkenyl group having from 8 to 24 carbon atoms. The betaine, suphobetaine and N-oxidised derivatives of (I) are provided for use as mild surfactants.
Patent DE-69310179-T2 (DE)
Inventor: LANEY MAUREEN
IPC: C12Q1/68
Filed: 1993-07-30
Granted: 1997-07-31
Abstract: A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide and a polynucleotide Q. The template polynucleotide has three sequences T1, T2 and T3 wherein T1 is non-contiguous and 3' of T3 and wherein the 5' end of T3 is 5' of the 5' end of T2. The primer polynucleotide has a second defined sequence at its 3' end that is hybridizable with T1. The blocker polynucleotide has sequence B1 that is hybridizable with T3. Polynucleotide Q has sequences S1 and S2 wherein S1 is 3' of S2 and homologous with T2 and S2 is complementary to a first defined sequence that is to be introduced at the 3' end of the polynucleotide primer, when it is extended during the method of the invention. Polynucleotide Q is either attached to the 5' end of the blocker polynucleotide or present as a separate reagent. The primer is extended along the template polynucleotide and along at least a portion of sequence T2 and thereafter along the polynucleotide Q to give a single stranded polynucleotide having two or more defined sequences.
Patent DE-69313265-T2 (DE)
Inventor: ARACIL MIRA JOSE
IPC: C07C67/08
Filed: 1993-12-16
Granted: 1998-03-05
Abstract: The selective esterification of a fatty acid and a polyalcohol is carried out by using, as a catalyst, zeolites and zeotypes of large pore, preferably with rings of twelve members (faujasite, mordenite etc.), with acid or base characteristics; saturated or unsaturated fatty acids with 4 to 22 carbon atoms are used, preferably oleic, palmitic, estearic and isoestearic acid, and diols or triols, preferably glycerine. The reaction is carried out at a temperature comprised between 100 and 190  DEG C, with pressures comprised between 5kPa and 200 kPa. The zeolites and zeotypes may be used as catalyst directly or included in a matrix such as Al2O3, silica, caolin, amorphous alumina-silica or any other known matrix.
Patent DE-69324572-T2 (DE)
Inventor: DUONG QUOC
IPC: C08L95/00
Filed: 1993-02-23
Granted: 1999-11-18
Abstract: PCT No. PCT/CA93/00074 Sec. 371 Date Dec. 30, 1993 Sec. 102(e) Date Dec. 30, 1993 PCT Filed Feb. 23, 1993 PCT Pub. No. WO93/17076 PCT Pub. Date Sep. 2, 1993.In accordance with the present invention, there is provided an asphalt composition which incorporates asphalt in admixture with synthetic or natural rubber and a vulcanizing agent. There is also provided a process for preparing the above asphalt composition. Preferably, the rubber is obtained from waste tires or tubes.
Patent DE-69334204-T2 (DE)
Inventor: TIEDEMANN EDWART G JR
IPC: H04L12/403
Filed: 1993-03-04
Granted: 2009-03-05
Abstract: Collisions between messages simultaneously transmitted by multiple spread spectrum transmitters are reduced by distributing the transmissions over the available resources of the receiver. Each mobile station uses one or more randomization methods to distribute its transmissions. Each mobile station includes a microprocessor (100); an encoder (140); a timing generator (136); a PN long code sequence generator (146); and XOR gate (152). The system is used in a CDMA mobile telephone system.
Patent DE-69402419-T2 (DE)
Inventor: IANNICE ARMANDO
IPC: B60K37/06
Filed: 1994-05-02
Granted: 1997-10-09
Abstract: The compact control unit (1) for motor vehicles has a tubular case (3) mounted on the gearshift (2) of a motor vehicle. The case (3) is closed at the top by a cover (6, 7) that forms a base on which the controls and indicator elements of several accessory driving functions are grouped and appropriately distributed.
Patent DE-69409277-T2 (DE)
Inventor: LI XIAOLING
IPC: C08F220/10
Filed: 1994-02-08
Granted: 1998-08-27
Abstract: A new polymer has a polymerisation feed mixt. of (a) a polymerisation initiator, (G) 0-5 mole.% based on the total of all monomers, present, of a vinylic copolymerisation crosslinker, and (c) one of the following mixt. (i) or (iii) where (i) is (I), 42-58 mole % of siloxy silane of formula (I), (II) 42-58 mole % of an unsubstd. alkyl (meth)acrylate of formula (II), (III) 0-5 mole % of a Gp. A monomer, and (IV) 0-16 mole % of an additional vinylic copolymerisable monomer of Gp. B, or where (iii) is (I) 16-42 mole % of siloxysilane I, (II) 42-58 mole % of alkyl (meth)acrylate II, (III) 0-5 mole % of a Gp A monomer and (IV) 0-36 mole % of a Gp B monomer. In the formulae, R1 = H or CH3; R2 = 1-6C alkylene; n = 0-2; R3 = H or CH3; R4 = CH3 or linear or branched 2-10C unsubstd. alkyl. Gp. A monomers are (meth)acrylic acid, maleic acid, fumaric acid, itaconic acid, cinnamic acid, crotonic acid, 2-(meth)acryloxyloxyethyl sulphonic acid, 2-(meth) acrylamido -2-methylpropane sulphonic acid, vinyl sulphonic acid, p-styrene sulphonic acid, allyl sulphonic acid and monomers of the formula (III). (R5 = H or CH3; R6 = 1-10C linear or branched alkyl, opt. substd. by CH, 1-4C alkoxy, Cl, Br, F, CO2H, 1-4C alkoxycarbonyl, 1-4C alkylcarbonyloxy or NH2). Gp. B monomer is neither a polymerisation inhibitor, a cross-linker nor a cpd. of formula (I) or (II) nor a Gp A monomer, but is a mono-satd. monomer copolymerisable with (I), (II) or Gp A cpds.
Patent DE-69412044-T2 (DE)
Inventor: EASTLAND PHILIP HENRY DONALD
IPC: C07B61/00
Filed: 1994-01-06
Granted: 1998-12-10
Abstract: Prodn. of alcohols and diols by hydrogenation of corresp. monoesters of (di)carboxylic acids, diesters of dicarboxylic acids, lactones and mixts. compsns. (a) providing hydrogenation zone contg. charge of granular heterogeneous Cu-contg. ester hydrogenation catalyst; (b) supplying a vaporous feedstream contg. H2 and an hydrogenatable material selected from 1-4C alkyl monoesters of 8-18C monocarboxylic acids, di-1-4C alkyl diesters of 4-12C dicarboxylic acids, gamma butyrolactone and mixts. of inlet temp. above dew point of mixt.; (c) maintaining hydrogenation zone at 150-350[deg]C and pressure of 150-2,000 psia; and (d) recovering a two-phase prod. stream contg. alcohol or acid at exit temp. below dew point.
Patent DE-69413420-T2 (DE)
Inventor: OHRN HARALD
IPC: H04M3/493
Filed: 1994-12-16
Granted: 1999-05-27
Abstract: In a method of ordering services, like booking hotel rooms, the ordering is performed via a user terminal connected to a central data processing device. A service request is specified and information of a service is retrieved from a data base in the central data processing device. When a given service offer is selected, a connection is automatically established between the user terminal and service location terminal via the central data processing device, whereupon the desired service can be ordered and the order confirmed. Further orders can be placed before the connection is broken. When an order has been made, the data base is automatically updated from the service location. A system is also specified for implementing the method. In a telemarketing system, a suitable user terminal may be a touch-tone telephone. The user terminal may also be a dedicated terminal with software for specifying the order.
Patent DE-69417411-T2 (DE)
Inventor: KANNINEN SEPPO
IPC: F24F3/044
Filed: 1994-04-22
Granted: 1999-08-19
Abstract: A method for controlling the operation of an air-conditioning apparatus comprising devices (1, 2, 3) for supplying outdoor air (A) into a room (4), for removing indoor air (B) from the room, and for returning removed indoor air as return air (C) into the room; and devices (9, 16, 20) for adjusting the amounts of outdoor air, removed air, and return air. The adjusting devices are adjustable for controlling the mixing ratios between the air amounts according to desired air conditions to be created in the room. To achieve a greater controllability of the apparatus and to improve the accuracy of the mixing ratios, the outdoor air (A) and the return air (C) are passed into the room alternately, and the durations of the open periods of the adjusting devices are adjusted so that a desired mixing ratio is achieved between the amounts of outdoor and return air in the room. An air-conditioning apparatus developed for applying the method comprises operating means (22) arranged to open the adjusting devices (9, 20) of an outdoor air duct (5) and a return air duct (19) alternately for the duration of the open periods.
Patent DE-69421945-T2 (DE)
Inventor: PERVAN TONY
IPC: E04F15/02
Filed: 1994-04-29
Granted: 2000-04-27
Abstract: The invention relates to a system for laying and mechanically joining building panels, especially thin, hard, floating floors. Adjacent joint edges (3, 4) of two panels (1, 2) engage each other to provide a first mechanical connection locking the joint edges (3,4 ) in a first direction (D1) perpendicular to the principal plane of the panels. In each joint, there is further provided a strip (6) which is integrated with one joint edge (3) and which projects behind the other joint edge (4). The strip (6) has an upwardly protruding locking element (8) engaging in a locking groove (14) in the rear side (16) of the other joint edge (4) to form a second mechanical connection locking the panels (1, 2) in a second direction (D2) parallel to the principal plane of the panels and at right angles to the joint. Both the first and the second mechanical connection allow mutual displacement of joined panels (1, 2) in the direction of the joint.
Patent DE-69501791-T2 (DE)
Inventor: BROWN ALAN
IPC: A61P25/18
Filed: 1995-09-29
Granted: 1998-07-02
Abstract: PCT No. PCT/EP95/03884 Sec. 371 Date Apr. 3, 1997 Sec. 102(e) Date Apr. 3, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/11195 PCT Pub. Date Apr. 18, 1996Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R2 is R3R4C(OH)A; V is C=O or CH2; W is O or NR5; R3 and R4 are each independently selected from H and C1-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R5 is H, benzyl, C1-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene; m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.    <IMAGE>  (I)   <IMAGE>  (a)
Patent DE-69501965-T2 (DE)
Inventor: BICKEL SYLVAIN
IPC: F24C15/20
Filed: 1995-01-11
Granted: 1998-08-13
Abstract: The oven has an inner chamber (6) to receive the food to be cooked, and an external wall (2) forming the exterior of the oven. A fume collection area (8) occupies part of the space between the cooking chamber and the external wall. A passage (7) connects the interior of the cooking chamber to the fume collection area. The passage houses a block of a catalytic material (28).  A sensor (30) responsive to temperature or composition of the fumes is placed beyond the catalyst in the collection area. The sensor controls operation of a fan (13) that blows air through the fume collection area, aiding transport of the fumes to the outlet (14) at the front of the oven, and increasing rate of drawing of fumes through catalyst.
Patent DE-69507191-T2 (DE)
Inventor: MARTIN PHILIPPE R
IPC: B24B3/06
Filed: 1995-05-09
Granted: 1999-06-17
Abstract: The reamer tool includes a cylindrical or conical body having a spherical end (3) which constitutes the active part of the tool. This end includes several channels (30) inclined by a given angle w.r.t. the longitudinal axis of the reamer. The channels are formed following an arc of circle at a given distance (x) from the median plane (p) of the reamer. An internal face and an external face of each of the channels form a cutting edge and a polishing edge respectively after machining. <IMAGE>
Patent DE-69507731-T2 (DE)
Inventor: TSUCHIDA YUJI
IPC: C05F17/00
Filed: 1995-03-30
Granted: 1999-09-30
Abstract: It is intended to provide a method and apparatus for composting a garbage and the like having a high water content by having it efficiently dehydrate, dry and ferment. Organic matters having a high water content is composted by: a fermentation and decomposition step in which organic matters containing a large amount of water is held in a treatment tank under supply of air for not less than one hour and not more than three hours at a temperature from ordinary temperature to not more than 60 DEG C while heating, agitating and grinding them to make them into a rice porridge state and to have it perform aerobic fermentation, and generated gas and water vapor are extracted to the outside of the treatment tank to perform the dehydration and drying thereof into a water content of not more than 65 %; a thermal decomposition step in which a temperature of a fermentation and decomposition product is held for no less than one hour and not more than six hours at not less than 60 DEG C and not more than 100 DEG C to thermally decompose the fermentation and decomposition product, and generated gas and water vapor are extracted to the outside of the treatment tank to perform dehydration and drying thereof into a water content of not more than 45%; and a final drying step in which a temperature of a thermal decomposition product is held for not less than one hour and not more-than six hours at not less than 100 DEG C and not more than 135 DEG C to perform sterilization, and the generated gas and water vapor are extracted to the outside of the treatment tank to perform dehydration and drying thereof into a water content of not more than 30%. <IMAGE>
Patent DE-69518000-T2 (DE)
Inventor: SOMERS C
IPC: C07K5/065
Filed: 1995-11-16
Granted: 2000-12-07
Abstract: The present invention comprises growth hormone releasing peptides/peptidomimetics (GHRP) capable of causing release of growth hormone from the pituitary. Compositions containing the GHRP's of this invention are used to promote growth in mammals either alone or in combination with other growth promoting compounds, especially IGF-1. In a method of this invention GHRP's in combination with IGF-1 are used to treat Type II diabetes. An exemplary compound of this invention is provided below. <CHEM>   <IMAGE>
Patent DE-69518194-T2 (DE)
Inventor: BROADHURST MICHAEL JOHN
IPC: A61K31/454
Filed: 1995-04-12
Granted: 2001-05-31
Abstract: The invention provides hydroxamic acid derivatives of the general formula <CHEM> wherein R<1> represents cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R<2> represents a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring which is attached via the N atom and which, when it is monocyclic, optionally contains NR<4>, O, S, SO or SO2 as a ring member and/or is optionally substituted on one or more C atoms by hydroxy, lower alkyl, lower alkoxy, oxo, ketalized oxo, amino, mono(lower alkyl)amino, di(lower alkyl)amino,carboxy, lower alkoxycarbonyl, hydroxy-methyl, lower alkoxymethyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or hydroxyimino; R<3> represents a 5- or 6-membered N-heterocyclic ring which (a) is attached via the N atom, (b) optionally contains N, O and/or S, SO or SO2 as an additional ring member, (c) is substituted by oxo on one or both C atoms adjacent to the linking N atom and (d) is optionally benz-fused or optionally substituted on one or more other C atoms by lower alkyl or oxo and/or on any additional N atom(s) by lower alkyl or aryl; R<4> represents hydrogen, lower alkyl, aryl, aralkyl or a protecting group; m stands for 1 or 2 and n stands for 1-4, and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful in the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis or in the treatment of invasive tumours, atherosclerosis or multiple sclerosis. They can be manufactured either by hydroxamidating a corresponding novel carboxylic acid or by deprotecting a corresponding novel benzyloxycarbamoyl compound.
Patent DE-69518924-T2 (DE)
Inventor: DUVICK JONATHAN
IPC: A01N63/50
Filed: 1995-08-11
Granted: 2001-01-18
Abstract: Methods for identifying organisms capable of degrading fumonisin. Fumonisin can be incorporated into culture medium for selection of organisms resistant to fumonisin and/or capable of growing on fumonisin as a sole carbon source. Using this method, several organisms have been identified. These organisms can be used to isolate the enzyme and the gene responsible for conferring fumonisin-resistance. The gene can be cloned and inserted into a suitable expression vector so that the protein can be further characterized. Additionally, the DNA encoding for fumonisin-resistance can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. Methods for detoxification in grain processing and in animal feed and rumen microbes are also disclosed.
Patent DE-69525542-T2 (DE)
Inventor: WEI LIWEN
IPC: C08G65/16
Filed: 1995-10-03
Granted: 2002-10-31
Abstract: Cyclic ethers are polymerized or copolymerized in homogeneous liquid phase using very low concentrations of heteropolyacid catalyst to produce essentially linear polyoxyalkylene polymers. The product of the polymerization contains less than 2 weight percent cyclic oligomer by-product and has a molecular weight distribution (Mw/Mn) between 1 and 2. Alcohols, acyl-containing compounds and alkalies can be used as end-caping groups to terminate polymerization or modify the properties of the polymer produced. The process produces novel polyoxyalkylene copolymers and block copolymers that are useful as lubricants. The copolymers have a high viscosity index and are compatible with mineral oil and synthetic hydrocarbon lubricants. Preferred comonomers are tetrahydrofuran, C2-C20 monoepoxides and oxetan.
Patent DE-69533899-T2 (DE)
Inventor: HUDKINS ROBERT L
IPC: A61P25/16
Filed: 1995-10-03
Granted: 2005-12-08
Abstract: Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed motoneuron death.. The disclosed compounds are represented by the following general formula:   <CHEM> Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.
Patent DE-69632820-T2 (DE)
Inventor: CABILLY SHMUEL
IPC: B01D57/02
Filed: 1996-04-26
Granted: 2005-07-07
Abstract: A cassette (10) for conducting therein electrophoresis separation which includes a closed chamber (11), the chamber includes therein a body of gel (18), means (20,22) for providing ions for driving the electrophoresis separation and electrodes (24,26) for connecting the cassette (10) to an external electrical power source, thereby enabling to drive the electrophoresis separation. <IMAGE>
Patent DE-69633728-T2 (DE)
Inventor: OGATA TOMOHIKO
IPC: H05K1/03
Filed: 1996-06-17
Granted: 2005-12-22
Abstract: A photosensitive ceramic green sheet having an inorganic powder and a photosensitive organic component as essential components, characterized by satisfying -0.05 </= N2 - N1 </= 0.2 where N1 is the average refractive index of the organic component and N2 is the average refractive index of the inorganic powder is used to provide a highly accurate ceramic package with a high aspect ratio.
Patent DE-69700171-T2 (DE)
Inventor: RICHARD HERVE
IPC: A61K8/89
Filed: 1997-10-28
Granted: 1999-07-29
Abstract: Substituted s-triazine compounds of formula (I) are new: in which R<1> = a radical -NH-F, R<2> = a radical -NH-Z-W, R<3> = R<1>, R<2>, 1-20 C linear or branched alkyl, 2-20 C linear or branched hydroxyalkyl, 1-20 C linear or branched alkoxy, NHR<8> or N(R<8>)2 in which R<8> = 1-20 C linear or branched alkyl, F = a filter chromophore, Z = a divalent radical linking -NH- and -W, W = either (i) a silicone radical comprising at least one unit of formula -Si(R)aO(3-a)/2 in which R = a 1-30 C saturated or unsaturated hydrocarbon group, a 1-8 C halogenated hydrocarbon group or a trimethylsilyloxy group and a = 1 or 2, or (ii) a radical of formula -SiR'<1>R'<2>R'<3> in which R'<1>, R'<2> and R'<3> (same or different) = 1-8 C linear or branched alkyl or alkenyl groups.