baber/WOPTO huggingface dataset:
Patent SG-10201505437Q-A (SG)
Title: A method for sharing functionality and/or data between two or more linked entities
Inventor: DEVONSHIRE KARYN
Filed: 2007-10-15
Abstract: The invention provides a computer network to provide access to data and functionality contained in one or more remote devices, the computer system comprising: two or more devices each containing a real object that allows access to data and provides functionality; and wherein, in use, each device is able to access data and functionality in a remote device by use of a pair of virtual objects, a first virtual object is positioned in the device for communication with the real object, and a second virtual object is positioned in the remote device for communication with the first virtual object. 
The virtual object may extract data and functionality from the real object so as to make the data and functionality independent of operating system of the real object. An object may be a software application that can store data and provide functionality in the manipulation of the data.
Patent SG-10201703032Y-A (SG)
Title: Product
Inventor: FARSHAD SHISHEHCHIAN
Filed: 2017-04-12
Abstract: Disclosed herein is a bacterial formulation that includes a bacteria selected from the genus Bacillus and a porous substrate material, wherein the bacteria is supported on and/or within the substrate material. Also disclosed herein are uses of the bacteria formulation, as well as methods of manufacture and regeneration of said formulation. [No Figure]
Patent SG-10201802281X-A (SG)
Title: Assay For The Diagnosis Of Dermatophytosis
Inventor: HARDER MELANIE
IPC: C12N15/11
Filed: 2018-03-20
Abstract: Summary Assay for the diagnosis of dermatophytosis The present invention relates to a primer pair comprising a forward primer and a reverse primer for amplifying a nucleic acid from a pathogen associated with a skin, hair and nail 10 infection comprising SEQ ID N022, a nucleic acid capable of hybridizing specifically to a nucleic acid sequence from a pathogen associated with a skin, hair and nail infection comprising SEQ ID N022, a carrier comprising the nucleic acid, a method comprising the step detecting in a sample a nucleic acid sequence comprising SEQ ID N022 from a pathogen associated with a skin, hair and nail infection, a use of the primer pair, the nucleic 15 acid or the carrier for the diagnosis of a disease and a kit comprising the primer pair, the nucleic acid and/or the carrier for the diagnosis of a disease. [no suitable Figure]
Patent SG-10201805033X-A (SG)
Title: Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
Inventor: VANDYCK KOEN
Filed: 2014-07-25
Abstract: 5 GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B Inhibitors of HBV replication of Formula (IA) 10 (IA) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1to R 6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV 15 inhibitors, in HBV therapy. [No available figure]
Patent SG-11201709274U-A (SG)
Title: Plug-in packaging method, device, terminal and storage media
Inventor: LI YING
Filed: 2017-02-22
Abstract: PLUG-IN PACKAGING METHOD, DEVICE, TERMINAL AND STORAGE MEDIA A plug-in packaging method, device, terminal and storage media. The method includes: obtaining an executable file created by compiling a source code of a host project; obtaining a base library of the host project that includes at least one compiled public base method; compiling plug-ins required to be packaged respectively by multi-thread based on the base library of the host project; storing the compiled plug-ins required to be packaged into resources of the host project; and packaging the executable file and the resource of the host project together into an apk packet. The above method could improve the packaging speed of the entire apk. FIG. 1
Patent SG-11201806609T-A (SG)
Title: Cancer evolution detection and diagnostic
Inventor: ELTOUKHY HELMY
IPC: G06F19/18
Filed: 2017-02-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 10 August 2017 (10.08.2017) WIPO I PCT (10) International Publication Number WO 2017/136603 Al 111111111111110111011111111111010111110 011101111111110011111011111111111110111111 Collect genetic profile data on a population of tumors and original tumor treatment(s) (10) W O 20 17 / 136603 Al (51) International Patent Classification: C12Q 1/68 (2006.01) GOOF 19/18 (2011.01) (21) International Application Number: PCT/US2017/016295 (22) International Filing Date: 2 February 2017 (02.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/290,375 2 February 2016 (02.02.2016) US (71) Applicant: GUARDANT HEALTH, INC. [US/US]; 505 Penobscot Drive, Redwood City, CA 94063 (US). (72) Inventors: ELTOUKHY, Helmy; 2 Barry Lane, Atherton, CA 94027 (US). TALASAZ, AmirAli; 2181 Caminio A Los Cerros, Menlo Park, CA 94025 (US). (74) Agents: STRONCEK, Jacqueline et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [Continued on next page] (54) Title: CANCER EVOLUTION DETECTION AND DIAGNOSTIC (57) : The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a sub- = ject with cancer, will develop a subsequent state. Such probabilities can be used to inform a health care provider as to particular courses of treat- ment to maximize probability of a desired outcome for the subject. Identify one or more evolutionary paths of escape and evolved tumor treatment(s) (12) Based on a subject profile, predicting a probability of escape along the one or more evolutionary paths (14) FIG. 1 WO 2017/136603 Al MIDEDIMOMOIDEIR01013011100MOIMMOVOIMIE TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3))
Patent SG-11201806696W-A (SG)
Title: Anti-citrullinated hla polypeptide antibodies and uses thereof
Inventor: MOBLEY JAMES LESLIE
IPC: A61K38/10
Filed: 2017-02-10
Abstract: anthr.,;fs Affi.s• Etif):Ii. , Ant•i- , AP (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/139577 Al 17 August 2017 (17.08.2017) WIPO I PCT 111111111111110111011111111111010111110 011101111111100111111111111111111110111111 (51) International Patent Classification: A61K 38/08 (2006.01) A61K 38/10 (2006.01) (21) International Application Number: PCT/US2017/017373 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/293,621 10 February 2016 (10.02.2016) US (71) Applicant: CAYMAN CHEMICAL COMPANY IN- CORPORATED [US/US]; 1180 East Ellsworth Road, Ann Arbor, Michigan 48108-2419 (US). (72) Inventor: MOBLEY, James Leslie; 10195 Covington, Brighton, Michigan 48116 (US). (74) Agent: ALBERDI, Fernando; 315 East Eisenhower Park- way, Suite 100, Ann Arbor, Michigan 48108-3330 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: ANTI-CITRULLINATED HLA POLYPEPTIDE ANTIBODIES AND USES THEREOF W O 20 17 / 139577 Al FIG. 1 (57) : The present invention relates to methods for treating an autoimmune disease in a human subject mediated by the presence of a citrullinated epitope QKCitAA, QRCitAA, or RRCitAA in the subject, the method comprising administering a thera- peutically effective amount of an antibody or a specific binding fragment thereof that specifically binds to citrullinated epitope QK - CitAA, QRCitAA, or RRCitAA. Further aspects of the invention include an antibody or a specific binding fragment thereof, that specifically binds to a human citrullinated epitope QKCitAA, QRCitAA, or RRCitAA.
Patent SG-11201809406P-A (SG)
Title: Construct and vector for intragenic plant transformation
Inventor: SCHENK PEER MARTIN PHILIPP
IPC: C12N15/82
Filed: 2017-04-27
Abstract: N O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 November 2017 (02.11.2017) WIP0 I PCT ill 111111110111010100111 Hot omolimm minion oimIE (10) International Publication Number WO 2017/185136 Al (51) International Patent Classification: C12N 15/09 (2006.01) Cl 2N 15/82 (2006.01) C12N 15/63 (2006.01) (21) International Application Number: PCT/AU2017/050383 (22) International Filing Date: 27 April 2017 (27.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016901547 27 April 2016 (27.04.2016) AU (71) Applicant: NEXGEN PLANTS PTY LTD [AU/AU]; Level 7, General Purpose South Building, The University of Queensland, Brisbane, Queensland 4072 (AU). (72) Inventors: SCHENK, Peer Martin Philipp; 76 Lancelot Street, Tennyson, Queensland 4105 (AU). NOWAK, Eka- terina; 41 Wellington Street, Ormiston, Queensland 4160 (AU). (74) Agent: FISHER ADAMS KELLY CALLINANS; Level 6, 175 Eagle Street, Brisbane, Queensland 4000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: CONSTRUCT AND VECTOR FOR INTRAGENIC PLANT TRANSFORMATION Mid SfRbc33C ITCA1 AA ACTAi.3 - 1 CAC 3' 332hp Figure 1 (57) : Genetic constructs are provided at least a fragment of which are insertable into the genetic material of a plant, wherein at least a fragment of the genetic construct comprises, consists essentially of, or consists of one or more nucleotide sequences derived from one or more plants. Also provided is use of the genetic construct for the production of genetically improved plants, and improved plants improved thereby. The improved plants may have desirable disease resistance, abiotic stress tolerance, or nutritional, palatability, or morphological properties.
Patent SG-11201810217Q-A (SG)
Title: Air conditioning device
Inventor: KIBATA SHINNOSUKE
IPC: F25B1/00
Filed: 2016-08-16
Abstract: KPO-2998 16 An air-conditioning apparatus includes: an outdoor unit including a compressor and an outdoor air temperature detector detecting an outdoor air temperature; an outdoor controller performing rotation-locked energization in accordance with the outdoor air temperature; and an indoor controller transmitting a power feeding ON 5 signal to the outdoor controller, wherein, under operation stop of the compressor, the outdoor controller includes a storage unit storing the outdoor air temperature detected by the outdoor air temperature detector every certain period of time, turns on, upon receiving the power feeding ON signal from the indoor controller, power feeding to the outdoor unit, and performs heating necessity determination to determine whether or not 10 heating of the compressor is necessary in accordance with a current outdoor air temperature and an outdoor air temperature stored in the storage unit, and when it is determined that heating of the compressor is necessary, performs the rotation-locked energization, and, when it is determined that heating of the compressor is unnecessary, stops power feeding to the outdoor unit. 15
Patent HU-194034-B (HU)
Title: Method for producing food-preparation substituting milk
Inventor: HUTAS ISTVAN
IPC: A23J3/00
Filed: 1985-02-22
Abstract: The prods. are prepd. from protein and starch contg. base materials of animal or vegetable origin by hydrolysing the materials or their mixt. in aq. suspension after treatment with aq. solns. of sodium-silicate or silicic-acid in concns. of 0.1-40.0 wt.%, adjusting the pH of the resulting suspension with 5-20 wt.% acid soln. to 7.0-7.5, opt. adding intestinal flora and/or a fat mixt. and/or milk concentrate and/or serum concentrate and/or vitamin soln. and/or antibiotics and/or yield improving additives and/or other known additives, and finally evaporating or spray drying the resulting colloid soln.
Patent HU-191317-B (HU)
Inventor: JAGICZA LASZLO
IPC: G06K11/00
Filed: 1985-03-05
Abstract: A találmány tárgya érzékelő elrendezés kétdimenziós analóg alakzatok, különösen vonalas rajzok, műszaki rajzok digitalizálására, amely érzékelő elrendezésben elhatárolt síkrészben egymáshoz képest tetszőlegesen elmozgatható érzékelő tömb (1) és digitalizálandó alakzat hordozó (2) van, továbbá az érzékelő tömb (1) kimenete digitális jelfeldolgozó egységre csatlakozik. A találmánynak az a lényege, hogy az érzékelő tömbje (1) két, egymásra merőleges irányban, egymástól függetlenül elmozgathatóan van elrendezve és az érzékelő tömbön (1) érzékelő elemek (6) vannak, amely érzékelő elemek (6) vonal(ak)at, előnyösen az elmozgatási irányokkal szöget bezáró egyenes(eke)t alkot(nak).  7   ε  XX   i ',<·   i 3. ábra -1-
Patent LT-3463-B (LT)
Title: Process for preparing pure isoflavone derivatives
Inventor: KALLAY TAMAS
IPC: A61K31/352
Filed: 1993-07-13
Abstract: PCT No. PCT/HU90/00023 Sec. 371 Date Dec. 5, 1991 Sec. 102(e) Date Dec. 5, 1991 PCT Filed Apr. 6, 1990 PCT Pub. No. WO91/15483 PCT Pub. Date Oct. 17, 1991.The invention relates to a process for the preparation of pure isoflavone derivatives of the general formula (I),    <IMAGE>  (I)  wherein R stands for hydrogen or isopropyl, R2 and R3 stand for hydrogen or C1-2 alkoxy by reacting a rezorcinol-derivative of the general formula (III)    <IMAGE> (III) wherein R2 and R3 are as given above with ethyl-orthoformiate of the formula (IV) (C2H5O)3l CH(IV) in the presence of a base and optionally by alkylating the product.
Patent SE-336552-B (SE)
Inventor: GENTRY H
IPC: B65B41/06
Filed: 1968-01-17
Abstract: 1,221,000. Packaging machines. MEAD CORP. 1 April, 1968 [14 Sept., 1967], No. 15662/68. Heading B8C. Reciprocable feeder means adjacent the path of movement of a plurality of articles engage the side of a blank to feed it towards and adjacent the path where blank advancing means move the blank in the same direction as the articles and out of the way of the feeder means, Blank folding means, on each side of the path, then immediately fold the blank about the article sides. In one embodiment, two suction cups 9, Fig. 1, on pivoted arms 10 engage the end blank B in a magazine 2 and carry it downwardly to a position adjacent a set of bottles A moving on a conveyer 8. Arms 38, 39 positioned on each side of the bottles, rotate clockwise to push the blank in the direction of movement of the bottles so that the suction cups can swing upwardly to engage the next blank. Fingers 42, 43 integral with the arms 38, 39 fold the blank about the bottle sides. In a further embodiment, arms (65, Fig. 3) oscillate to and fro about a pivot (66) to push the blank B clear of the suction cups (45). Arms (69), forming part of the linkage which oscillates the arms (65) carry fingers (79) which describe an elliptical orbit (80) to fold the blank down about the sides of the bottles. The blank may have apertures for receiving the necks of bottles or slits for receiving the corners of cans.
Patent ZA-87885-B (ZA)
Title: Removal of lipid soluble chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
Inventor: WOODS KENNETH R
IPC: A61L2/00
Filed: 1987-02-06
Abstract: A method of removing lipid soluble process chemicals from biological materials containing the lipid soluble process chemicals comprising bringing the biological materials containing the lipid soluble process chemicals into contact with an effective amount of a naturally occurring oil extracted from a plant or an animal or a synthetic compound of similar chemical structure, agitating the resultant mixture, separating out an upper-phase and a lower-phase by sedimentation and decanting the upper-phase. The method is particularly useful for producing relatively virus free physiologically acceptable plasma.
Patent ZA-96543-B (ZA)
Title: A method for mounting an electronic module in a card body
Inventor: TARANTINO THOMAS
IPC: G06K19/077
Filed: 1996-01-26
Abstract: The module incorporates a supporting film (5) with contact surfaces (2) on one side, and windows for the integrated circuit (4) and its wire bonds (3) which are encapsulated in resin (7). A ring (6) of thermally activated adhesive secures the underside of the module into the recess in the body (1) of the card. The assembly is carried out in two stages. First the adhesive is heated and then the module is inserted into the recess under pressure with or without additional heating.
Patent AT-409443-B (AT)
Title: Cereal product comprising cereal germ and other grain components, comprises extrudate in which sugars are caramelized
IPC: A23L7/152
Filed: 1998-11-26
Granted: 2002-08-26
Abstract: The extrudate comprises granulated cereal germ and grain or ground-cereal products, or grain malt products, in which the sugars are caramelized.  An Independent claim is included for the method of manufacture. The mixture is extruded, subjecting it to short-term temperature- and pressure increase. At the extruder, especially in the extruder cylinder, heating causes outward caramelization of the sugars. Simultaneously a pressure is build up and the mixture reaches granular form. Preferred features: The granules are comminuted to grit- or meal consistency. They are flaked or ground.
Patent AT-389517-B (AT)
Title: Chromophoric peptides, process for their preparation and their use for detecting the peptidylglycine alpha- amidating monooxygenase
IPC: C07K5/062
Filed: 1987-10-08
Granted: 1989-12-27
Abstract: The invention relates to chromophoric peptides of the formula DIS-D-Ala-Pro-R in which R is Gly-OH or NH2, and DIS is 5- dimethylaminonaphthalene-1-sulphonyl, a process for their preparation and their use for detecting the peptidylglycine alpha-amidating monooxygenase.
Patent AT-383816-B (AT)
Title: Use of benzofuran-2-one compounds and indolin-2-one compounds as stabilizers
IPC: C08K5/15
Filed: 1980-02-05
Granted: 1987-08-25
Abstract: Use of benzofuran-2-one compounds and/or indolin-2-one compounds, and/or indolin-2-one compounds which in the 3- position have either at least one hydrogen atom or one organic radical bonded via a double bond, and/or unsubstituted or substituted bis-3-benzofuran-2-one compounds and/or unsubstituted or substituted bis-3- indolin-2-one compounds as antioxidants for polymeric organic materials, where i 3H-benzofuran-2-one compounds unsubstituted at the 3-position do not have tert-butyl- sterically-hindered hydroxy at the 5-position, ii in indolin-2-one compounds whose nitrogen atom at the 1- position has bonding to hydrogen, alkyl or aralkyl, only the 3-position bearing another substituent, this does not have acetamide structure, and iii when use is made of 3- acylbenzofuran-2-ones the polymeric organic material is substantially halogen-free, and polymeric materials thus stabilized. Novel benzofuran-2-one compounds and novel indolin-2-one compounds whose molecule contains at least two benzofuran-2-one or indolin-2-one ring structures bonded to one another either directly at their 5-position or via an organic bridge at the 3-, 5- or 7-position.
Patent AT-382376-B (AT)
Title: Process for the preparation of novel carbostyril compounds and the pharmaceutically acceptable salts thereof
Inventor: MICHIAKI TOMINAGA
IPC: C07D215/22
Filed: 1981-11-11
Granted: 1987-02-25
Abstract: Process for the preparation of novel carbostyril compounds I in which the meaning of the substituents is stated in the description, and of the pharmaceutically acceptable salts thereof. The compounds I and their pharmaceutically acceptable salts have a cardiotonic effect. <IMAGE>
Patent CA-1212665-B (CA)
Inventor: FOGLIO MAURIZIO
IPC: C07D205/09
Filed: 1986-01-14
Granted: 1986-10-14
Abstract: ABSTRACT OF THE DISCLOSURE         There is disclosed a process for the preparation of .beta.-lactam-containing compounds of the formula   where R is hydrogen, lower alkyl, trichloroethyl, acetonyl, benzyl, substituted benzyl, phenyl, substituted phenyl, benzyldryl or a residue that will undergo metabolic activation "in vivo" and have favorable pharmacokinetic properties:  R1 is a hydrogen atom, lower alkyl, lower alkoxy, cycloalkyl, or hydroalkyl, with the alcoholic fun-ction of the hydroxy alkyl being free or protected; Z is hydrogen, halogen, hydroxy, amino, carbamoyloxy, mercapto, pyridinium, OR2, OCOR2, NHCOR2, or SR3 wherein each of R2 and R3 is lower alkyl, aryl, or a heterocyclic ring, each of which may be substituted or unsubstituted, and n is 0 or 1.  The compounds have wide spectrum antibacterial activity and .beta.-lactamase inhibiting activity.