baber/WOPTO huggingface dataset:
Patent JP-2005529820-A (JP)
IPC: B65G47/80
Filed: 2003-05-19
Abstract: The invention concerns a method for adjusting the component-holder supports of a conveyor rotary drum of electronic components for compensating, even completely correcting, mistakes and inaccuracies occurring during previous manufacturing steps of the conveyor through individual adjustment of the position of each component-holder support relative to a reference position.
Patent JP-2005535891-A (JP)
Title: ハイブリダイゼーション反応後に、超音波を用いて固体基板を洗浄するための方法および装置
IPC: C12Q1/68
Filed: 2002-12-10
Abstract: ハイブリダイゼーション反応後に、超音波を用いて固体基板を洗浄するための方法および装置が提供される。この方法は、（１）固体基板を洗浄溶液を有する容器中に配置し、この基板上でハイブリダイゼーション反応を完了させる工程、（２）超音波発生器を使用して特定の強度の超音波を生じ、この超音波を洗浄溶液中に伝達する工程、（３）超音波により洗浄溶液中に発生するキャビテーション効果によって、基板を洗浄する工程を包含する。洗浄溶液中のキャビテーション気泡は、固体基板に対して強烈な流出物と局所的な微小スリップ流を生じ得、液体の表面張力と摩擦を明らかに減少させ、液体の流れを増強するので、非特異的な吸着および固体基板上に弱く結合した堆積が、迅速に洗い流され得る。
Patent JP-2005537566-A (JP)
Title: 集積回路においてフィルターされたインターコネクションに関する配線寄生を抽出する方法
IPC: G06F17/50
Filed: 2003-07-16
Abstract: 集積回路のパフォーマンスをシミュレートするために寄生抵抗と容量値を抽出するための方法（２００）、システム（１００）、及びコンピュータプログラム製品である。集積回路において選択される数のインターコネクションが識別され得る（２０４）（重要なインターコネクション）。集積回路のトランジスタリストを含むネットリストは、重要なインターコネクションの駆動側のチャネル接続される領域における、ネットリスト内のトランジスタと、重要なインターコネクションの受信する側のトランジスタを選択することによって、簡略化され得る（２０５，２０６）。重要なインターコネクションに接続されるレイアウト層の寄生抵抗と容量値が抽出され得る（２０８）。これらの抽出された寄生抵抗と容量値は、簡略化されたネットリストにおけるこれらのレイアウト層に接続されるトランジスタと関連付けられ得る（２０９）。上述した寄生抵抗及び容量値を抽出することによって、ＲＣ抽出における計算量を抑えることができるので、結果として、使用されるメモリ量とプロセッシングパワーを抑えることができる。
Patent JP-2006502809-A (JP)
Title: 体内の異常、及び不整合を検出するための装置、及び方法
IPC: A61B5/053
Filed: 2003-10-17
Abstract: 異常または不整合を検出するためのシステム、及び同じものを利用する方法が提供される。特にコンピュータシステムは、被験者の一部分の中のインピーダンスの変化が発生したことを示す内部インピーダンスデータを生成することよって、少なくとも被験者の一部分の中の異常または不整合を検出するように構成されることができる。インピーダンスの変化は、被験者の少なくとも一部分の中の流体の流速の変化、流体の量の変化等のような被験者の中の血管の少なくとも１つの特徴の変化、または被験者の一部分の中の異物の存在と関連付けられることができる。代表的な実施例において、被験者の中のインピーダンスの変化を示す連続的なリアルタイムの内部インピーダンスマップ、または被験者の中のインピーダンスの変化が発生したことを示す複数の固定的な内部インピーダンスマップを生成することによって、被験者の中の異常または不整合を検出することが可能である。
Patent JP-2006502066-A (JP)
Title: 選別品の少なくとも二つの部分流を、選別品の全体流へ合流するための装置
IPC: B07C1/04
Filed: 2003-07-03
Abstract: 本発明によれば、合流区間（１６）において、少なくとも二つの選別物品（６，１０）の部分流（４，８）を、選別物品（６，１０）が互いに十分等しい間隔で配設された間隔を有する、選別物品（６，１０）の全体流（１８）に合流する装置（２）が設けられており、 ａ）少なくとも一つの第一部分流（４）内に、中断可能に運転される引き出し装置（１２）と、この中断可能に運転される引き出し装置（１２）の後方で接続される第一の加速可能な区間（３４）が設けられており、 ｂ）少なくとも一つの第二部分流（８）内に、中断されること無く運転される引き出し装置（１４）と、この中断されること無く運転される引き出し装置（１４）の後方で接続される第二の加速可能な区間（３６）が設けられており、及び ｃ）制御装置（ＣＵ）が設けられており、この制御装置が、全体流（１８）において、選別物品（６ａ〜６ｇ，１０ａ〜１０ｄ）の十分等しい間隔で配設された間隔を保証するために、中断されること無く運転される引き出し装置（１４）により、捌かれる選別物品（１０ａ〜１０ｄ）を、第二の加速可能な区間（３６）で中間弛緩するかあるいは加速する。 このようにして、ルーズリーフ挿入物を備えた広告用パンフレット、ダイレクトメール等のような、取り扱いに問題がある選別物品を、中断の結果として生じる紙詰まりの危険にさらされることなく、第二部分流において、連続的に堆積体から捌かれた形状で引き出すことが可能である。
Patent JP-2006504534-A (JP)
IPC: B21B31/10
Filed: 2003-09-23
Abstract: In order to shorten the delivery path of working rolls for their replacement in a rolling mill with support plates which are provided on an operating side (BS) of roll stands (F 1 -Fi), are displaced transversely to roll axes, are outfitted for receiving working roll sets ( 4 ), and are located adjacent to a mill floor level ( 7 ) for transporting the working rolls ( 4 ) back and forth, and with trenches ( 10 ) which are arranged upstream of respective roll stands (F 1 -Fi) on the operating side (BS) and a base ( 11 ) of which is outfitted for delivery of back-up roll sets ( 9 ), it is suggested that a transport device ( 12 ) be associated a transport device ( 12 ) is associated with the support plates ( 2 ) for transporting respective support plates ( 2 ) back and forth between a position for replacing the working rolls and in which the support plates ( 2 a) are arranged immediately adjacent to the roll stands above the trenches ( 10 ), and a position of replacing back-up rolls and in which the support plates ( 2 c) are located beneath the mill floor level ( 7 ) adjacent to a trench region.
Patent JP-2006509445-A (JP)
Title: 無線通信システムにおけるＱｏＳ起動のためのトラフィッククラスサポートを提供する装置及び関連方法
IPC: H04B1/707
Filed: 2003-12-10
Abstract: ＣＤＭＡ２０００やその他のパケット無線通信システム（１０）において、トラフィッククラスを利用する装置及び関連方法であって、通信設定手順に応じて、トラフィッククラス指定が識別され使用される。要求内において識別されたクラス信号に応じて、通信リソースの割り当てが実行される。トラフィッククラス信号生成器（５２）により、要求されたトラフィッククラスを識別する値を生成し、フォーマッタ（５４）により、通信リソースの割り当てに使用するＱｏＳ  ＢＬＯＢ（４２）などのメッセージに、トラフィッククラスをフォーマットする。
Patent JP-2006510226-A (JP)
Title: 回転可能な送出アームから流体を送出する装置及び方法
IPC: B05C5/02
Filed: 2003-12-15
Abstract: 本発明は、回転自在な液体送出アーム(50)及びノズル(54)を用いて流体をウェーハトラックモジュール内に制御自在に送出する装置及び方法である。装置は、フォトレジストでコーティングされた基板(W)を支持し且つ回転させるスピンチャック(44)と、それに隣接して取付けられた回転可能なアーム(50)を有する。アーム(50)は、現像液及び濯ぎ液等の流体源(52)に接続された送出ノズル(54)を支持し、送出ノズル(54)は、流体を送出するノズルチップ(56)を有する。ノズルチップ(56)を基板(W)の表面に向ける送出位置と、現像液等が基板上に滴下する恐れを減少させるようにノズルチップ(56)を基板(W)の表面から遠ざける非送出位置との間で、送出ノズル(54)を選択的に位置決めするために、アーム(50)はその長手方向軸線周りに回転可能である。
Patent JP-2006513216-A (JP)
Title: 上気道うっ血を治療するための組成物および方法
IPC: A61K31/495
Filed: 2003-12-19
Abstract: 患者における上気道および口咽頭うっ血ならびに関連症状を治療するための鎮咳薬、うっ血除去薬および抗ヒスタミン薬としてのジフェンヒドラミンの組成物。ジフェンヒドラミンは、抗ヒスタミン効果をもたらすことに加えて、抗コリン薬、鎮痛薬、鎮咳薬および鎮痛補助薬としての効果ももたらす。
Patent JP-2006193608-A (JP)
Title: Method for compounding urethane rubber component
Inventor: FUJIMOTO TSUNEO
IPC: C08G18/00
Filed: 2005-01-13
Abstract: <P>PROBLEM TO BE SOLVED: To provide a method for compounding urethane rubber components always enabling high charge accuracy to be stably secured for each of the plurality of liquid components while seeking equipment simplification and cost reduction, thus contributing to significantly improving product yield.  <P>SOLUTION: The method comprises charging a component-compounding vessel 8 with one of the urethane rubber constituent liquid components via the 1st charging step of charging the liquid component through the larger-diameter nozzle 4A of an extrusion nozzle 4 from a tank 9 subjected to air back pressure AP and closing the larger-diameter nozzle 4A at a point when the charging amount comes to about 97% measurement determined by a relevant balance 7, and the 2nd charging step of closing a smaller-diameter nozzle 4B when the measurement of another one of the liquid components charged through the smaller-diameter nozzle 4B comes to such a value that the charge amount from the beginning of closing the nozzle 4B to the ending of closing it is deducted from a set charge amount, and charging the vessel 8 with the other liquid components via similar steps.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006193083-A (JP)
Title: Steering control device for vehicle
Inventor: SATO OSAMU
IPC: B62D5/04
Filed: 2005-01-14
Abstract: <P>PROBLEM TO BE SOLVED: To provide a steering control device for a vehicle capable of reflecting a delay in a steering actuator caused by an inputted load and further capable of realizing an application of a steering reaction force corresponding to its original steering state.  <P>SOLUTION: This steering control device for a vehicle comprises a front wheel steering angle estimation model block 107 for estimating a front wheel steering angle in response to a desired steering angle θ<SB>h</SB>and a response characteristic of a front wheel steering actuator 102, a steering angle sensor for detecting an actual front wheel steering angle θ<SB>p</SB>, and a steering reaction force correcting means (a gain block 112 and adding block 114) for the more correcting the desired steering reaction force F, the larger the difference between an estimated steering angle θ<SB>t</SB>and the actual front wheel steering angle θ<SB>p</SB>is.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006194035-A (JP)
Title: Locking device
Inventor: YAMAGUCHI KEIJI
IPC: E05B1/00
Filed: 2005-01-17
Abstract: <P>PROBLEM TO BE SOLVED: To provide a locking device securely preventing from forgetting locking in the locking device formed in a door knob.  <P>SOLUTION: The locking device has a knob part 2a provided in the door knob 2 and rotatably formed between vertical arrangement and horizontal arrangement and a door lock part 3 operating interlocked with displacement of the knob part 2a and inserted into a locking hole 4a provided in a position opposed to the door 4 in accordance with horizontal arrangement of the knob part 2a and enabling locking between the door 4 and the locking hole 4a. The locking device has a locking weight part 1b attached to the knob part 2a and displacing the knob part 2a toward horizontal arrangement by its own weight.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006037943-A (JP)
Title: Exhaust emission control system of internal combustion engine and purification capacity regenerating method for exhaust emission control system
Inventor: TOSHIOKA TOSHISUKE
IPC: B01D53/94
Filed: 2005-01-17
Abstract: <P>PROBLEM TO BE SOLVED: To provide a technology capable of securely or efficiently performing NOx reducing treatment or SOx poisoning recovery treatment in an exhaust emission control system having an NOx catalyst.  <P>SOLUTION: When NOx or SOx is reduced on the NOx catalyst by supplying a reducer to the NOx catalyst, the flow of exhaust emission passing an exhaust passage is changed, and a fuel as the reducer is added to the exhaust emission passing the exhaust passage at multiple timings (ΔT<SB>1</SB>, ΔT<SB>2</SB>) with different flows of exhaust emission.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006208530-A (JP)
Title: Liquid crystal display device
Inventor: SATAKE TETSUYA
IPC: G02F1/1337
Filed: 2005-01-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide a liquid crystal display device capable of obtaining high contrast by suppressing light leakage during black display.  <P>SOLUTION: The liquid crystal display device comprises an electrode substrate providing a plurality of pixel electrodes; an opposite substrate arranged oppositely to the electrode substrate and aligned in a substantially parallel direction to alignment processing of the electrode substrate; and a chiral nematic liquid crystal sandwiched between the electrode substrate and the opposite substrate and divided into at least two bend alignment regions in each pixel by an electric field between a pixel electrode and the opposite electrode. The liquid crystal display device arranges a shading layer (auxiliary capacity electrode 20) in at least one of the electrode substrate and the opposite substrate positioned at a boundary of the adjacent vent alignment region in each pixel.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006211140-A (JP)
Title: Image correction device, image correction program, data converter, and data conversion program
Inventor: AOKI YASUHARU
IPC: G06T1/00
Filed: 2005-01-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide an image correction device which can perform an image correction with sufficient skill and can perform flexible image correction matched with a user's intent; and to provide an image correction program, a data converter, and a data conversion program.  <P>SOLUTION: The image correction device includes an image analysis part which performs a predetermined image analysis to an image, an image corrector which performs an image correction according to the result of the image analysis by the image analysis part to the image set as the object of the image analysis, a specification part which performs by responding the content of the image correction to an operation for directing directly or indirectly, and a processing controller which performs the correction of the content specified by the designation in the image corrector for the image specified by the specification part.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006209867-A (JP)
Title: Manufacturing method of disk type information medium
Inventor: OSE TAKAYOSHI
IPC: G11B7/26
Filed: 2005-01-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a manufacturing method of a disk type information medium which can suppress generation of defects by suppressing contraction irregularity which is liable to be generated at drying time after applying an application liquid for ink receiving layer in production of the disk type information medium by forming an ink receiving layer on a label face.  <P>SOLUTION: This is a manufacturing method of a disk type information medium comprising a printable layer including at least an ink receiving layer with thickness of 20-50 μm on a substrate. The manufacturing method of the disk type information medium is characterized by including a printable layer formation process which forms the printable layer by performing a dry up process by blowing dry wind of 10-40°C on the application face at wind velocity 0.5-5 m/sec after applying the application liquid for ink receiving layers for forming the ink receiving layer on the substrate.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006205905-A (JP)
Title: Mount structure of power unit for vehicle
Inventor: YOSHIDA HIROYUKI
IPC: B60K5/12
Filed: 2005-01-28
Abstract: <P>PROBLEM TO BE SOLVED: To simplify a structure, and to reduce the number of parts by solving problems such as a complicated structure to result in increase in the number of parts.  <P>SOLUTION: A torque rod 70 is composed of a unit side coupling portion 72 coupled to a power unit 31 side, a rod portion 73 extended from the unit side coupling portion 72 to a vehicle body frame 20 side, and a vehicle body frame side coupling portion 74 provided at a tip end of the rod portion 73. The vehicle body frame side coupling portion 74 is composed of a ring portion 85 integrally provided on the rod portion 73, an elastic member 87 arranged on the ring portion 85, and a supporting pin 86 penetrating the elastic member 87 and supported on the vehicle body frame 20 side. At least an outer peripheral surface 87a of the elastic member 87 on the rod 73 side, is relatively tilted in regard to the supporting pin 86.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005320319-A (JP)
Title: Anti-oxidizing composition and product containing the same
Inventor: KATAYAMA GENJIRO
IPC: A23L1/30
Filed: 2005-01-28
Abstract: <P>PROBLEM TO BE SOLVED: To obtain an anti-oxidizing composition which can prevent the oxidation of lipid in a body with active oxygen, and to provide a product containing the same.  <P>SOLUTION: The anti-oxidizing composition is characterized by containing a lutein ester and a black rice extract. It is preferable that the W<SB>L</SB>/W<SB>P</SB>ratio of the lutein ester mass W<SB>L</SB>/black rice extract mass W<SB>P</SB>is 0.2 to 5. It is preferable that the sum (W<SB>L</SB>+W<SB>P</SB>) of the lutein ester mass W<SB>L</SB>and the black rice extract mass W<SB>P</SB>is 0.1 to 50 mass % based on the total amount of the anti-oxidizing composition. A food containing the anti-oxidizing composition, and a tablet containing the anti-oxidizing composition are disclosed.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006208864-A (JP)
Title: Optical transmissions medium
Inventor: KOYANO MASUTAKA
IPC: G02B6/00
Filed: 2005-01-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide an optical transmissions medium having improved outgoing light quantity and superior emission efficiency.  <P>SOLUTION: The optical transmissions medium (1) is structured by sealing a transparent liquid (1a) in a flexible tubular container (1b), wherein a tapered part is formed in a sealing cap (2) attached to the exiting section of the optical transmissions medium (1).  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006210275-A (JP)
Title: Cylindrical alkaline battery
Inventor: SANO MASAHIRO
IPC: H01M2/12
Filed: 2005-01-31
Abstract: <P>PROBLEM TO BE SOLVED: To provide a cylindrical alkaline battery having a self-restoration type explosion-proof structure which can be repeatedly used, capable of surely preventing leakage of alkaline electrolyte when the explosion-proof structure is operated.  <P>SOLUTION: A bottom part of a positive electrode can 11 having a vent hole 14 is covered by a positive electrode terminal plate 12. A reciprocal pressure operation valve is formed by closing the vent hole 14 by a rubber valve 13 arranged between the bottom part of the positive electrode can 11 and the positive electrode terminal plate 12 in compressed state. A gas permeable and non-liquid permeable film 16 is arranged on an exhaust passage extending from inside of the positive electrode can to the outside of the battery 10.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006207777-A (JP)
Title: Multiple disc clutch device
Inventor: KO TOSHIAKI
IPC: F16D13/69
Filed: 2005-01-31
Abstract: <P>PROBLEM TO BE SOLVED: To provide a multiple disc clutch device capable of securely preventing fixation of metallic plates of both plates when a friction member causes loss, being set simply, and reducing cost.  <P>SOLUTION: A spacer function is provided on a driven plate 1 to prevent fixation of the driven plate 1 and a metallic plate of a board of a drive plate 2. A spacer is a cap-like cover 11 composed of one plate and attached to a projection-shaped part 1a for spline fitting of the driven plate. In a usual operation condition, the spacer (the cover 11) does not come into contact with the next driven plate 1 due to thickness of the drive plate 2, but (b) shows a condition in which a lining 3 causes loss on only one side and which is the minimum condition of fixation when the lining 3 causes loss and the driven plate 1 attempts to be fixed to the drive plate 2 to prevent fixation by the drive plate 2 by the spacer (the cover 11) function.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006204815-A (JP)
Title: Game machine and program for game
Inventor: SAKAMOTO HIROMICHI
IPC: A63F7/02
Filed: 2005-01-31
Abstract: <P>PROBLEM TO BE SOLVED: To improve the interest of a game in a performance relating to the game without increasing the storage burdens of image data in a game machine such as a pachinko game machine provided with the three-dimensional display function for an image.  <P>SOLUTION: The pachinko game machine is provided with a liquid crystal display device for displaying images and the variable display and stop display of patterns are performed in the display area 16a of the liquid crystal display device. Then, the pachinko game machine generates a three-dimensional display image to be displayed in the display area 16a, changes the three-dimensional display image to be generated for two or more times from the start of the variable display of the patterns to the end of the variable display, decides the number of times of the change, and makes the changed three-dimensional display image be displayed.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006217705-A (JP)
Title: Current control method
Inventor: SATO KAZUO
IPC: H02P29/00
Filed: 2005-02-02
Abstract: <P>PROBLEM TO BE SOLVED: To curtail circuits and its cost without dropping speed control.  <P>SOLUTION: A servo controller, which drives a servo motor 9, is equipped with a speed control means 8. It controls the servo motor in quick response in place of current control.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006214525-A (JP)
Title: Controlling method for externally controlled fan clutch
Inventor: SHIOZAKI MASARU
IPC: F01P7/04
Filed: 2005-02-03
Abstract: <P>PROBLEM TO BE SOLVED: To provide a control method for an externally controlled fan clutch capable of stabilizing rotation control of a fan and reducing fuel consumption.  <P>SOLUTION: The control method controls opening and shutting of a valve member of the externally controlled fan clutch having a mechanism for opening and shutting control of an oil supply adjusting hole by the valve member operated with an electromagnet by means of PID control (proportional, differential, and integral feedback control method) at the basis of at least one signal among signals for radiator coolant temperature, fan rotation speed, oil temperature of a transmission, speed of a vehicle, acceleration at an accelerator (throttle) position, pressure of a compressor of an air conditioner, and On or Off signals of the air conditioner. A target fan rotation speed control line corresponding to an amount of necessary cooling air is selected among a plurality of target fan rotation speed control lines in which predetermined input rotation speed is set to be a variable, and consequently, PID operation is performed at the basis of this selection.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2006214678-A (JP)
Title: Indoor unit for air conditioner
Inventor: YAMAMOTO MASAHITO
IPC: F24F13/20
Filed: 2005-02-04
Abstract: <P>PROBLEM TO BE SOLVED: To provide an indoor unit of an air conditioner capable of protecting a connection wire rod distributed in a main body housing while preventing the impairing of workability such as wiring work of the connection wire rod in the main body housing, and assembling work and maintenance work of the indoor unit of the air conditioner.  <P>SOLUTION: The main body housing 12 is long over its both side end portions, a wire rod storing portion 121 having a grooved portion 122 formed into the groove shape for storing the connection wire rod distributed in the main body housing is formed near a lower end portion of a cabinet 12, and the connection wire rod is stored in the grooved portion 122 of the wire rod storing portion 121. As the connection wire rod is stored in a state of being consolidated in the grooved portion of the wire rod storing portion, the assembling work and the maintenance work of the indoor unit of the air conditioner can be implemented without disturbed by the connection wire rod, and the workability can be improved.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patent JP-2005190495-A (JP)
Title: Lsi design assisting method
Inventor: HIRANO SHOZO
IPC: H01L21/82
Filed: 2005-02-14
Abstract: <P>PROBLEM TO BE SOLVED: To identify an EMI occurrence position of an LSI for which an analysis is carried out to take efficient measures.  <P>SOLUTION: This method comprises: an undesired radiation analyzing step for analyzing a quantity of undesired radiation of an LSI by execution of simulation; a step for selecting an instance with a large quantity of noise in the undesired radiation analyzing step; and a step for adjusting a driving capability of the instance so that it is lowered to an extent that a delay does not occur in a signal timing of the instance selected. In order to optimize the analyzed undesired radiation, the portion for which optimizing is required is extracted, and such a measure as increasing the area where the decoupling capacitance is created is implemented for this portion in a necessary degree. Further, by changing the aspect ratio of the block, changing the block position or changing the cell line, the decoupling capacitance can be easily created at the most efficient inserting position.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patent JP-2005312434-A (JP)
Title: Method for producing high-purity granulocyte colony-stimulating factor
Inventor: IDO TAKAYOSHI
IPC: A61K38/00
Filed: 2005-02-17
Abstract: <P>PROBLEM TO BE SOLVED: To prepare a high-purity G-CSF (granulocyte colony-stimulating factor) with which a recombinant baculovirus having the full-length cDNA of a natural type G-CSF and the high-purity G-CSF is prepared according to a method for column chromatographic purification in order to develop the G-CSF as a medicine.  <P>SOLUTION: Several kinds of column chromatographic purifications are studied for the purpose of preparing a high-purity purified product having a physiological activity by paying attention to especially the G-CSF expressed/produced by an insect cell. As a result, a method for purifying the G-CSF preparable as a parenteral injection of 95% purity is established. The G-CSF is obtained as the result of the studies by using a cell culture supernatant containing the G-CSF produced by the insect cell according to the several kinds of column chromatographies. The method for high-purity production is carried out by combination of a cation exchange carrier with a hydroxyapatite column. Thereby, the high-purity G-CSF can be prepared and the G-CSF preparable as the parenteral injection can thereby be prepared.  <P>COPYRIGHT: (C)2006,JPO&NCIPI