baber/WOPTO huggingface dataset:
Patent CR-20190318-A (CR)
Inventor: LI JINGWEI
IPC: C07D513/04
Filed: 2017-12-21
Abstract: Se describen compuestos de Fórmula (I), métodos para utilizar los compuestos como inmunomoduladores y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos son útiles para tratar, prevenir o mejorar enfermedades o trastornos tales como el cáncer o las infecciones.Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
Patent CR-20220660-A (CR)
Title: METHODS FOR TREATING OR PREVENTING SARS-CoV-2 INFECTIONS AND COVID-19 WITH ANTI-SARS-CoV-2 SPIKE GLYCOPROTEIN ANTIBODIES
Inventor: HERMAN GARY
IPC: C07K16/10
Filed: 2021-06-02
Abstract: The present invention provides methods for preventing and treating SARS-CoV-2 infections, COVID-19, or symptoms thereof. The methods of the invention feature the administration of one or more antigen-binding molecules (<em>e.g.</em>, antibodies) that bind a surface protein of SARS-CoV-2 (<em>e.g.</em>, spike protein).
Patent CR-20230144-A (CR)
Title: Probiotic compositions for the treatment of acne
Inventor: NAVARRO LÓPEZ VICENTE
IPC: A61P17/10
Filed: 2021-09-14
Abstract: Probiotic compositions are provided in the present invention that comprise bacterial strains L. rhamnosus CECT 30031 and bacterial strain Arthrospira platensis (Spirulina paraca). The disclosed probiotic compositions are useful in the treatment of acne.
Patent EC-SP003573-A (EC)
Title: Tancha (tanque de tela abierto)
Inventor: VACA MONCAYO PABLO FEDERICO
IPC: E04H4/04
Filed: 2000-07-14
Abstract: El inventor ha desarrollado un tanque que se produce encoger y doblar al que se le denomina "Tancha" consistente en una funda abierta de tela; la misma que estará sujeta a una estructura o malla exterior formada con perfiles plásticos, cordeles y bastones rígidos, los que al ensamblarse toman similar a un tanque cilíndrico abierto y con su estructura vista. Se fabrica sin moldeo y se puede utilizar varios materiales como madera, acero, telas y plásticos comoerciales y se le puede instalar en muchos sitios . Cuando se le termina de ensamblar ya puede tomar su forma característica y cuando se le llena se hincha un poco y aumenta su rigidez. Es liviana, flexible, se lo puede desmontar, doblar o envolver: puede ser empacada en uno, dos o tres partes y guardar es fácil su transporte y permite desenvolver y ensamblar a mano en otro diferente. Los componentes pueden ir sueltos y se pueden ensamblar entre si de manera siimple, unos son flexibles, otros semirígidos, y otros rígidos, los cuales al juntarse forman una estructura flexible mientras está vacía pero una vez llena adquiere rigidez.
Patent EC-SP045160-A (EC)
Title: Método y sistema de aislamiento en un motor de combustion interna para ahorrar combustible
Inventor: ANTHON ANTHONY
IPC: B32B15/14
Filed: 2004-06-17
Abstract: Un método y aparato para reducir el consumo de combustible en un motor de combustión interna incluyendo motores diesel, de nafta y gasolina usados en camiones, automóviles y para bombas, incluyendo los pasos de proveer una protección de aislamiento térmico que incluye una tela reflectora sobre el distribuidor de escape, alrededor del recinto de entrada para el aire de entrada y el colector de aire, cubriendo el compresor del turbosoplante con un material aislante del calor que incluye una capa de tela reflectora y la carcasa de la turbina de accionamiento del turbosoplante excepto el área de cojinetes para reducir mucho la formación de calor en el compartimiento del motor, reduciendo así la temperatura del aire de entrada para aumentar la eficiencia del motor. Se encontró que la invención aumenta la eficiencia de combustible en grandes camiones en un 10 a 15%. Los materiales son livianos y no aumentan significativamente el peso del motor o del camión.
Patent EC-SP066603-A (EC)
Title: Anticuerpos cd20 con funcion del efector y afinidad de enlace al receptor fc mejoradas
Inventor: UMANA PABLO
IPC: A61K39/395
Filed: 2006-06-02
Abstract: La presente invención se refiere a moléculas de enlace a antígenos (ABM). En modalidades particulares, la presente invención se refiere a anticuerpos monoclonales recombinantes, incluyendo anticuerpos quiméricos, primatizados o humanizados específicos para el CD20 humano. Además, la presente invención se refiere a moléculas de ácidos nucleicos que codifican tales ABM, y vectores y células hospederas que comprenden tales moléculas de ácidos nucleicos. La invención se refiere además a métodos para la producción de las ABM de la invención, y a métodos de uso de estas ABM en el tratamiento de la enfermedad. Además, la presente invención se refiere a ABM con glicosilación modificada que tiene propiedades terapéuticas modificadas, incluyendo anticuerpos con función del efector incrementada y enlace al receptor Fc incrementado.
Patent EC-SP066810-A (EC)
Title: Derivados de carbamato de 2h- ó 3h-benzo[e]indazol-1-ilo, su preparación y su aplicación en terapéutica
Inventor: SEVRIN MIREILLE
IPC: C07D401/12
Filed: 2006-08-29
Abstract: La invención se refiere a compuestos de la fórmula general (I): en la que W representa un átomo de oxígeno o de azufre; X1, X2, X3 y X4 representan cada uno de manera independiente el uno del otro, un átomo de hidrógeno o de halógeno o un grupo ciano, alquilo-C1 C6, fluoroalquilo-C1 C6, alcoxi-C1 C6 o fluoroalcoxi-C1 C6; Y está en posición (N2) o (N3); cuando Y está en posición (N2), Y representa un grupo alquilo-C1 C6, fluoroalquilo-C1 C6, arilo o heteroarilo; cuando Y está en posición (N3), Y representa un grupo arilo o heteroarilo; estando los grupos arilo o heteroarilo sustituidos opcionalmente con uno o varios átomos o grupos elegidos entre los átomos de halógeno, grupos alquilo-C1 C6, alcoxi-C1 C6, alquiltio-C1 C6, alquilo-C1 C6-S(O)-, alquilo-C1 C6-S(O)2- o fluoroalquilo-C1 C6; el enlace en posición C4-C5 es doble o sencillo; R1 y R2 representan cada uno, de manera independiente el uno del otro, un grupo arilo, bencilo o alquilo-C1 C6; o bien R1 y R2 forman, con el átomo de nitrógeno que los contiene un heterociclo sustituido opcionalmente con uno o varios grupos alquilo-C1 C6 o bencilo; en forma de base o de sal de adición de ácido, así como en forma de hidrato o de solvato. Proceso de preparación y aplicación en terapéutica.
Patent EC-SP088564-A (EC)
Title: Composiciones farmaceuticas que comprenden sustancias calcio antagonistas combinadas con antiagregantes plaquetarios para su uso en hipertensión arterial sistémica y la prevención de eventos vasculares de origen isquémico
Inventor: SANTOS MURILLO JOSEFINA
IPC: A61K31/616
Filed: 2008-06-20
Abstract: La presente invención está relacionada con la industria farmacéutica en general y con la industria farmacéutica productora de medicamentos para el control de la hipertensión arterial sistémica y la prevención de eventos vasculares de origen isquémico en particular. Más específicamente se trata de una composición formada por una sustancia hipotensora calcio antagonista en combinación con un agente antiagregante plaquetario. La composición se caracteriza en que dicha combinación o asociación consiste de una sustancia seleccionada antagonista de los canales de calcio conocida como Amlodipino besilato y un agente antiagregante plaquetario conocido como ácido acetilsalicílico; los cuales producen un producto con efecto sinérgico para el tratamiento de la hipertensión arterial sistémica y previene el riesgo de eventos vasculares de origen isquémico, con menores efectos secundarios.
Patent EC-SP109977-A (EC)
Title: Composición farmacéutica que comprende un derivado de benceno sustituido con glucopiranosilo.
Inventor: HIMMELSBACH FRANK
IPC: A61K31/00
Filed: 2010-02-19
Abstract: La invención se refiere a una composición farmacéutica de acuerdo con la reivindicación 1 que comprende un derivado de benceno sustituido con glucopiranosilo junto con un inhibidor de DPP IV, que es adecuada en el tratamiento o prevención de una o más afecciones seleccionadas entre diabetes mellitus de tipo 1, diabetes mellitus de tipo 2, alteración de la tolerancia a la glucosa e hiperglucemia. Además, la presente invención se refiere a métodos para prevenir o tratar trastornos metabólicos y afecciones relacionadas.
Patent EC-SP993134-A (EC)
Title: 1,2,3,4- tetrahidroquinolinas -2 -sustituidas 4- carboxiamino sustituidas
Inventor: RUGGERI ROGER BENJAMIN
IPC: A61K31/47
Filed: 1999-09-10
Abstract: Inhibidores de la proteína de transferencia de colesteril éster, composiciones farmacéuticas que contienen tales inhibidores y el uso de tales inhibidores para elevar ciertos niveles de lípidos en plasma, incluyendo colesterol de lipoproteínas de alta densidad, y para reducir ciertos otros niveles de lípidos en plasma, tales como el colesterol LDL y los triglicéridos y, por consiguiente, para tratar enfermedades que se excerban por los bajos niveles de colesterol HDL y/o altos niveles de colesterol LDL y triglicéridos, tales como la aterosclerósis y enfermedades cardiovasculares en algunos mamíferos, incluyendo los seres humanos.
Patent FI-19992114-A (FI)
Inventor: O'NEILL STEPHEN
IPC: B65D88/02
Filed: 1999-09-30
Abstract: A tank made of a plastic material, comprising at least one opening for conducting liquid into the tank. The inner surface of the tank (1) is substantially torus-shaped. The tank (1) can be provided with partitions (7) so that chambers are formed in the tank. The upper part of the partitions (7) can be provided with one or several holes, via which the waste liquid is able to flow from one chamber to another, i.e. the tank (1) operates as a septic tank.
Patent GB-1050803-A (GB)
Abstract: 1,050,803. Enzyme preparations. E. MERCK A.G. May 7, 1965 [May 25, 1964], No. 19455/65. Heading A5B. An orally administrable enzyme preparation is in the form of a coated tablet or dragee having an inner, enterically coated core containing pancreatin and ox bile and a layer exterior to the enteric coating containing bromelin.
Patent GB-1131359-A (GB)
Abstract: 1,131,359. Feeding cigarettes. PHILIP MORRIS Inc. 4 Nov., 1966, No. 49586/66. Heading B8S. [Also in Division A5] Apparatus for dispensing lighted cigarettes of two types for sampling may include a magazine 12 for the cigarettes 15 and arms 32, 32<SP>1</SP>, 33, 33<SP>1</SP> able to be rotated on shafts 28, 29 by a motor 35 so as to move a cigarette from the magazine over steps 25, 26 to a dispensing position 27 when a switch 16 is depressed. The apparatus may also include buttons 18, 19 able to record on a paper sheet 58 the results of the sampling, an indicating wheel 45 which records the number of cigarettes which have been dispensed, and a lamp which is focused so as to light each cigarette. It is stated that the apparatus may be modified for sampling other articles, such as " hot-dogs ".
Patent GB-1227142-A (GB)
IPC: C07K16/12
Filed: 1968-03-25
Abstract: 1,227,142. Separating IgM gamma globulins. POVIET PRODUCTION N.V. 25 March, 1968 [29 March, 1967; 5 Jan., 1968], No. 14317/68. Heading A5B. A so-called IgM gamma globulin fraction is separated from animal or human body fluids (milk, urine, plasma) by dialysis of the fluid against an aqueous medium with a pH of 4-9.5 either until the ionic strength of the fluid is 0.015 to 0.016 when the required fraction precipitates or by dialysing until the ionic strength is greater than 0.016 and diluting with water to the above ionic strength. In the latter case, the dialysis step may be that of electro-dialysis at pH 1.8 to 2.0. The precipitated material may be purified and worked up by conventional methods. It has haemagglutinating activity against colibacillus.
Patent GB-1230008-A (GB)
IPC: A47H13/12
Filed: 1968-08-19
Abstract: 1,230,008. Suspending curtains. W. HACHTEL. 19 Aug., 1968 [16 Sept., 1967], No. 39493/68. Heading A4B. A curtain runner 14 engages the rail at two positions spaced apart along the rail to resist tilting and has an integral, depending resilient bar 16 provided at its lower end with mushroom shaped formations 18 to support a curtain fastener 31, 32, the arrangement being such that the bar 16 deflects laterally relative to the remainder of the runner 14 in response to a pull on the curtain and thus alleviates binding of the runner in the rail. As shown, the runner may have guiding projections 26 engaged in the mouth 27 of a runner groove 24. In other embodiments (Figs. 1-4) the runner 14 is shaped to hook over a projecting rail (12). The runner may be slidable or may have rollers (13) engaged on the rail-(13).
Patent GB-1230745-A (GB)
IPC: G03B27/58
Filed: 1969-02-24
Abstract: 1,230,745. Cutting webs. METEOR-SIEGEN APPARATEBAU PAUL SCHECK G.m.b.H. 24 Feb., 1969 [12 Oct., 1968], No. 9867/69. Heading B4B. [Also in Divisions B8 and G2] In a method of servering web material while the leading portion thereof is moving continuously, the material to the rear of the leading portion is first accelerated relative to the leading portion to form a loop of predetermined length and then is stopped, the stationary web being severed while the loop is drawn away with the leading portion. A photo-copying machine embodying apparatus for performing said method comprises support means for copying paper storage rolls 4-6; first sets of transport rollers 9-12 for drawing paper from one of the rolls 4-6 to convey it past a cutter 16, 17 to continuously driven second transport rollers 22; a variable speed drive gear-box 42 for the first rollers 9-12; and means, Fig. 3 (not shown), for operating the cutter 16, 17 to sever the paper when brought to a stand. Cut sheets are delivered over a table 21 and guide 23 to transport belts 26, a master sheet introduced over a track 1 being superimposed at rollers 24, prior to reaching an exposure drum 27. Photo-electric devices 33, 36 for sensing the master sheet control the cutting and feeding mechanism to ensure correct superimposition. Drive mechanism.-The first rollers 9, 10 or 11 and 12 are each connected through a clutch, e.g. 12a, and through a common chain drives 12c, 40, to an output sprocket 37 of the gear-box 42. Input power is through a shaft 46 driven by a vee-belt 44 from a main drive regulated in speed according to the master copy density, and a gear 47 on the shaft 46 co-operates via a further gear 48 with a gear 51 fast with the sprocket 37 through a differential gear system. A pulse from the device 36 as it is passed by the trailing edge of the master sheet energizes a magnetic clutch 53, linking the shaft 46 with a cam disc 58 through spur gears 54-56 for one revolution of the disc, and a roller 63 follows the cam track 59, constraining a spindle 41 bearing planetary pinions 50 to rotate therewith via a lever 66, such that the pinions 50 cause an increase in the sprocket 37 speed, followed by a deceleration to rest. A further roller 64, Fig. 5 (not shown), co-operates with the cam track 59 to control a push-rod 67b for actuating the cutter knife 17. At the end of a cam disc revolution a pawl 69 enters a slot 11 in the disc 58, which may overrun slightly until a mounting arm 75 is stopped by the force of a spring member 76, whereupon it returns to the correct inoperative position. A lever 81 bearing a peg 80 which runs in a track 73 round the spur gear 55 is thus reversed slightly, the pin 80 entering a chord-like track 77 so that the pawl 69 is withdrawn.
Patent GB-1230859-A (GB)
IPC: G03G15/20
Filed: 1968-12-23
Abstract: 1,230,859. Apparatus for fusing toner. EASTMAN KODAK CO. Dec.23, 1968 [Dec. 27, 1967], No.60974/68. Heading G2H. An apparatus for fusing electroscopic toner on an image carrier 10 comprises a rotatable drum 11 having a glass or quartz sleeve 13 of high thermal radiation transmitting qualities, a radiant heater 40 within the drum and a reflector 44 for focusing radiant heat on to the carrier ahead of the nip formed between the drum 11 and a pressure roller 12. The sleeve 13 has a coating 50 of set-off preventing material, e.g. silicone varnish or fluorocarbon monomer. A wick 52 applies set off preventing liquid, e.g., silicone oil, vegetable oil, or a glyceride to the drum 11. The roller 12 is actuated towards the drum 11 by a solenoid 33 against a spring 34, under the control of a switch. An auxiliary heating element 46 and reflector 48 cause preheating of the carrier 10 ahead of the nip.
Patent GB-1250732-A (GB)
IPC: F16K17/40
Filed: 1970-02-03
Abstract: 1,250,732. Pressure relieving devices. GOODYEAR TIRE & RUBBER CO. Feb. 3, 1970 [March 4, 1969], No. 5084/70. Heading F1P. A pressure-relieving safety device which is particularly suitable for use in an aircraft wheel, comprises a housing 4 one end of which is screwthreaded as at 5 for engagement with corresponding screw-threads 2 of the wheel rim 3 and other end of which is apertured as at 19, 20 to provide communication with atmosphere, a sleeve 13 of fusible material, and a steel ball 14, the ball being pressfitted into the sleeve. Upon the pressure within the wheel exceeding a predetermined value, (determined by the material of sleeve 13), the ball is forced out of the sleeve and into housing chamber 9, Fig. 3, (not shown), so allowing pressure relief. In the event of the wheel temperature exceeding a predetermined value, (likewise determined by the sleeve material), the sleeve fuses and the ball enters housing chamber 9. In a modification, Figs.4 and 5, (not shown), the ball is substituted by a circular disc (31) cast into a restrained fusible material ring, excessive temperature or pressure causing the ring to fuse or fail, respectively, and the disc to enter the housing chamber.
Patent GB-1250781-A (GB)
IPC: E06C1/32
Filed: 1967-12-13
Abstract: 1,250,781. Folding ladder. H. P. KNIGHT. 11 Dec., 1968 [13 Dec, 1967], No. 56636/67. Heading E1S. [Also in Division A4] A folding ladder which may be converted, e.g., into a step ladder or a trestle, comprises at least three sections connected in end to end relation. At least two of the connections are hinges which are preferably U section pieces 6 and 7 overlapping the end of stiles and the U section on two adjacent stiles being pivotally connected at 8. Stays 12 may be provided to hold the sections at a given angle to each other. A second coupling device may be a sleeve which frictionally engages with two adjacent stiles (Fig. 9 not shown). A locking device may be provided to lock the sections in alignment which may be a U section member spring mounted in one stile with the legs extended therefrom and which fit in the abutting stile (Figs. 10 and 11 not shown). A second locking device is shown in Fig. 4, movement of lever 14 causes pin 19 to disengage from U-section hinge member 6 enabling the ladder to be folded.
Patent GB-1251618-A (GB)
IPC: B23K25/00
Filed: 1970-03-13
Abstract: 1,251,618. Casting; work supports. VYSKUMNY USTAV ZVARACSKY. 13 March, 1970 [13 March, 1969], No. 12231/70. Headings B3B and B3F. A grooved roll 14, on which a metal layer is to be cast by an electroslag process using an electrode 23 and a mould 25, rests (with its trunnions on rollers 15) on supports 1 mounted on a platform 3 which is movable on rollers 19 in the direction of the cylinder axis, the metal feed device 10 (and electrode 23) of the machine being supported on a turntable 9 vertically movable on pillars 7 (8) of the machine frame 6. The platform 3 is movable by a drive (21) on a carriage 4 between guides 20. The carriage is secured to the frame 6 by a screw 11 and nut 12 during casting, but for receiving a roll 14 for treatment it is released and withdrawn, to the position indicated in ghost lines, by an electric motor (24) slung beneath it. There may be more than one unit 10 having an electrode 23 supplied with a wire 26 to be melted.
Patent GB-1252044-A (GB)
IPC: C07C45/00
Filed: 1969-01-24
Abstract: 1,252,044. 11 #-Hydroperoxy-4,5-secosteroids. ROUSSEL-UCLAF. 24 Jan., 1969 [26 Jan., 1968], No. 58416/70. Divided out of 1,252,042. Heading C2C. Novel compounds of formula (wherein R is C 1-4  alkyl, K is a ketal group, Y is OH and Z is H or Y + Z is oxo) are prepared from the corresponding #<SP>9(11)</SP>-11-unsubstituted compounds by reaction with oxygen in a basic medium.
Patent GB-1257583-A (GB)
IPC: A47J37/04
Filed: 1970-05-11
Abstract: 1,257,583. Toasters. ANGLO-SWISS EQUIPMENT PRODUCTION Ltd. May 11, 1970, No. 22557/70. Heading A4D. Apparatus for cooking foodstuffs, particularly for toasting, comprises a generally rectangular heating chamber 1 containing a part of both of the runs of an endless conveyer belt or chain 13 and two preferably electrical heating elements 14 and 15, are above the upper run of the conveyer 13 and one between the runs, as shown. The conveyer 13 passes over at least two pulleys 6, 9 mounted on shafts 5, 8, the shaft 5 being driven by a variable speed electric motor (4), Fig. 3 (not shown). The shaft 5 is placed outside the chamber 1 in a space formed between extensions of the two elongate side walls (2), Fig. 2 (not shown), the motor (4) and all electrical terminals 16-18 and controls 23, 25, 26 being mounted in a casing 3 attached to the exterior surface of one of these extensions, which casing is thermally isolated from the chamber 1. In use, food to be heated is placed on the conveyer 13 outside the chamber 1 between the side wall extensions and is taken through the chamber and passes out via a slide 28, the amount of heating being governed by the speed of the conveyer 13 and the temperature of the elements 14, 15. A tray 21 for crumb collection may be provided and also an external rack 29. The conveyer 13 may be arranged with all or a portion of one run horizontal within the chamber.
Patent GB-1257791-A (GB)
IPC: B65D88/12
Filed: 1968-04-23
Abstract: 1,257,791. Cargo transporting platforms; securing containers to vehicles. CRAVENS HOMALLOY (SHEFFIELD) Ltd. 14 April, 1969 [23 April, 1968], No. 19220/68. Headings B8P and B8Q. A cargo transporting platform consists basically of a floor 10, end walls 12 and a number of longitudinally spaced anchorages 40 below the upper surface of the floor. The floor may consist of a number of transverse wooden planks supported by a metal section framework. A web, comprising a horizontal portion 36 and an inclined portion 38, extends between two of the outer members 16 on each side of the metal framework. A number of longitudinally spaced holes in each web are adapted to accommodate metal fittings 43 as anchorages for ropes. The wooden planks 32 immediately above the anchorages are detachable. The end walls are of pressed steel panels 20 flanked by corner posts 22 with corner castings 26 and 28 conforming to I.S.O. standards. The metal section framework is also supplied with pin castings 29. An optional P.V.C. coated nylon flexible cover 44 is supported by inverted U-section tubular members 46, which locate in holes 50, in a metal member 52 fixed to the outside of the metal framework, when the cover is extended.