baber/WOPTO huggingface dataset:
Patent CO-6220936-A2 (CO)
Title: 5-oxoisoxazoles como inhibidores de lipasas y fosfolipasas
Inventor: PETRY STEFAN
IPC: A61K31/42
Filed: 2009-09-30
Abstract: 1.- Un compuesto de la fórmula Ien la que los significados son: R1 alquilo (C5-C16), Y-arilo, Y-heteroarilo, donde el arilo o heteroarilo puede estar sustituido una o más veces con F, CI, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo (C1-C6), O-alcoxi (C1-C4)-alquilo (C1-C4), S-alquilo (C1-C6), alquilo (C1-C6), haloalquilo (C2-C4), O-haloalquilo (C2-C4), alquenilo (C2-C6), cicloalquilo (C3-C8), O-cicloalquilo (C3-C8), alquinilo (C2-C6)-, alquileno (C0-C8)-arilo, O-alquileno (C0-C8)-arilo, S-arilo, alquileno (C0-C8)-heteroarilo, N(R4)(R5), SO2-CH3, SO2-NH2, SF5, COOH, COO-alquilo (C1-C6), CON(R6)(R7), N(R8)CO(R9), N(R10)SO2(R11), CO(R12), (CR13R14)x- O(R15), O-CO-N(R16)(R17), O-CO-alquileno (C1-C6)-CO-O-alquilo (C1-C6), O-CO-alquileno (C1-C6)-CO-OH, O-CO-alquileno (C1-C6)-CO-N(R18)(R19), donde el arilo o heteroarilo puede estar sustituido, a su vez, una o más veces con F, CI, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo (C1-C6), O-alcoxi (C1-C4)-alquilo (C1-C4), S-alquilo (C1-C6), alquilo (C1-C6), haloalquilo (C2-C4), alquenilo (C2-C6), cicloalquilo (C3-C8), O-cicloalquilo (C3-C8), alquinilo (C2-C6), N(R4a)(R5a), SO2-CH3, SF5, COOH, COO-alquilo (C1-C6), CON(R6a)(R7a), N(R8a)CO(R9a), N(R10a)SO2(R11a), CO(R12a), (CR13aR14a)x-O(R15a), O-CO-N(R16a)(R17a), O-CO-alquileno (C1-C6)-CO-O-alquilo (C1-C6), O-CO-alquileno (C1-C6)-CO-OH, O-CO-alquileno (C1-C6)-CO-N(R18a)(R19a); x, x' 0, 1, 2, 3, 4, 5, 6; R4, R5, R6, R7, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R4a, R5a, R6a, R7a, R9a, R10a, R11a, R12a, R13a, R14a, R15a, R16a, R17a, R18a, R19a independientemente entre sí hidrógeno o alquilo (C1-C8); o un radical de la fórmula la con W -C(R26)(R27)-, -C(R26)(R27)-(R28)(R29)-, -C(R26)(R27)-O-R20, R21, R22, R23, R24, R25, R26, R27, R28, R29 son iguales o diferentes y son hidrógeno, F, CI, Br, I, OH, CF3, NO2, CN, OCF3, SF5, O-alquilo (C1-C6), O-alcoxi (C1-C4)-alquilo (C1-C4), S-alquilo (C1-C6), alquilo (C1-C6), haloalquilo (C2-C4), O-haloalquilo (C2-C4), alquenilo (C2-C6), cicloalquilo (C3-C8), O-cicloalquilo (C3-C8), ...
Patent CO-6270323-A2 (CO)
Title: Formas solidas de acido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-trifluoro- 1-(3'-metoxibifenil-4-il)etoxi)pirimidin-4-il)fenil)propanoico y metodos para su uso
Inventor: LIMURA SHINYA
IPC: A61K31/505
Filed: 2010-05-07
Abstract: Se describen formas solidas de acido (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il)etoxi)pirimidin-4-iI)fenil)propanoico y sales del mismo.1.- Un compuesto cristalino, que es acido (S)2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il) etoxi)pirimidin-4-il)fenil)propanoico o una sal del mismo.2.- Un compuesto cristalino, que es tosilato de (S)-2- amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metoxibifenil-4-il)etoxi)pirimidin-4-il)fenil)propanoato.3.- El compuesto cristalino de la reivindicacion 2, que es anhidro.4.- El compuesto cristalino de la reivindicacion 3, que tiene un punto de fusion de aproximadamente 241°C.5.- El compuesto cristalino de la reivindicacion 3, que tiene un patron de difraccion de polvo de rayos x que comprende un pico en uno o mas de aproximadamente 3.5, 7.0, 8.6, 10.9, 13.5, 14.0, 15.1, 17.3 y/o 20.5 2? grados.6.- El compuesto de la reivindicacion 3, que tiene un patron de difraccion de polvo de rayos x sustancialmente el mismo como el que se muestra en la Figura 1.7.- El compuesto cristalino de la reivindicacion 2, que es un hidrato.8.- El compuesto cristalino de la reivindicacion 7, que es un monohidrato.
Patent CO-6331298-A2 (CO)
Title: Vacunas contra coccidiosis
Inventor: LANG MARCELO
IPC: A61K39/12
Filed: 2010-11-22
Abstract: La presente invención describe una vacuna que proporciona la protección contra la coccidiosis, y métodos para producir y usar la vacuna sola, o en combinación con otros agentes protectores.
Patent CO-6612194-A2 (CO)
Title: Métodos de purificaciñon de adamts 13 y otras proteinas recombinantes y sus composiciones
Inventor: HASSLACHER MEINHARD
IPC: C12N9/64
Filed: 2012-02-14
Abstract: En la presente descripción se proporcionan métodos para purificar proteína desintegrina tipo A y metalopeptidasa con trombospondina 1, motivo 13 recombinante (ADAMTS13) de una muestra. El método comprende el enriquecimiento de la proteína ADAMTS 13 mediante el contacto cromatográfico de la muestra con hidroxiapatita, bajo condiciones que permitan que la proteína ADAMTS 13 aparezca en el eluato o sobrenadante proveniente de la hidroxiapatita. Los métodos pueden comprender además la cromatografía en tándem con una resma de interacción hidrofóbicalintercambio catiónico de modo mixto a la que se une la proteína ADAMTS 13. Las etapas adicionales opcionales involucran la ultrafiltración/diafiltración, cromatografia de intercambio aniónico, cromatografía de intercambio catiónico, e inactivación viral. En la presente descripción se proporcionan, además, métodos para inactivar los contaminantes virales en muestras de proteína, donde la proteína se inmoviliza sobre un soporte. En la presente descripción se proporcionan, además, composiciones de ADAMTS 13 preparadas de acuerdo con dichos métodos.
Patent EP-1024469-A2 (EP)
Inventor: GELSINGER TIMOTHY L
IPC: G09F3/10
Filed: 2000-01-26
Abstract: A self-adhesive label for a container, such as a
pharmaceutical bottle, comprises three sections. The first
and third sections adhere the label to the bottle. The second
section is contiguous with the first section, and is attached
to the third section by means of a perforation. This second
section is the "peel-away" section and contains printed
information on both its front and rear surfaces. The second
section has a non-adhesive rear surface and contains a tab
for ease of gripping. The second section may be torn along
the perforation by use of the grip tab, to enable viewing of
the information printed on the rear surface of the second
section of the label. The second section can then swing free
of the bottle, yet remains attached to the first section.
After reading the information contained on the rear surface
of the second section, the consumer can than reseal this
portion of the label to its original position on the bottle.
This is possible due to the presence of relatively minute
spots of adhesive on the rear surface of the second label
section which will reseal the label to the bottle until such
a time as the consumer wishes to reopen the label.
Patent EP-1029513-A2 (EP)
Inventor: PLAUMANN MANFRED THOMAS
IPC: A61C5/06
Filed: 2000-02-17
Abstract: For the production and application of dental preparations ready for use, the mixture and application capsule is for substances reacting with one another and comprises a cylindrical capsule body (1), a mixture chamber containing one of the components to be mixed and a foil cushion (5), in which a further component is contained, which is held by a clasp (2) on the side of the capsule body. An opening (7) is connected with the mixture chamber and is closed by a part of the foil cushion. An axially displaceable piston (6) pressed out the ready to use dental preparations and is arranged at the rear end of the capsule body. In the opening area of the mixture chamber is an outlet aperture (8). A non-bent cannula (4) for application purpose is fitted at an angle of 10 to 80 degrees on a closure cap (3) in relation to the longitudinal axis of the capsule body.
Patent EP-1034989-A2 (EP)
Inventor: KATO TAKEAKI
IPC: B60R21/2165
Filed: 2000-03-09
Abstract: An air bag deployment apparatus for a seat back (14)
includes a support bracket (40) and a strap (58). The
support bracket (40) has a reaction surface (52) which
extends rearwardly of an inflator (44) of an air bag
module (38). The strap (58) is sewn at one end onto a
trim cover (20) inside a frangible seam line (32) and
mounted at the other end to a frame (16). The reaction
surface (52) limits forward displacement of a rear
portion of the strap (58).
Patent EP-1043078-A2 (EP)
IPC: B05B17/08
Filed: 2000-03-20
Abstract: The equipment has a water container (2) fitted with thermal insulation (2a,4a). This contains all the devices and necessary electrical connections for automatic control of the fountain. A magnetic valve (36) operated by a float switch (32) ensures that container water level is maintained between max. and min. levels (33,34). The water passes through a filter (38) before gaining access to the float switch (24a) controlled pump (24)
Patent EP-1048893-A2 (EP)
Inventor: MACHURA HEINZ
IPC: F21S8/10
Filed: 2000-04-12
Abstract: The vehicle light has at least one elongated light conducting element (2) with end surfaces, at least one forming a light in coupling surface and a base part of a housing to which the light conducting element is attached. The light conducting element ha attachment elements (18,19) formed on its ends (12,13) next to the end surfaces.
Patent EP-1054184-A2 (EP)
Inventor: CLEMENS DIETMAR
IPC: F16F9/06
Filed: 2000-04-19
Abstract: The vibration damper has a working piston dividing a cylinder into two working chambers (2,3), and a compensation chamber (4 with at least one damper valve (1) positioned between working and compensation chambers. Each working chamber is connected to th compensation chamber via its own spring-loaded damper valve, and in opposite direction connected via a back pressure valve (5) t working chamber. The working chambers are relatively sealed by the axially moveable working piston, and both chambers are co-axi enclosed by the compensation chamber.
Patent EP-1053861-A2 (EP)
Inventor: MITAMURA HISASHI
IPC: B29C35/08
Filed: 2000-05-11
Abstract: A bladder for a vulcanizer according to the present invention
comprises, as a constituent member, a low elongation material which is hard
to be changed in properties under the environment of high temperature, and
being formed to have substantially the same shape as the shape of the inner
wall surface of a tire when a green tire is subjected to vulcanizing-molding
into a vulcanized tire, whereby irregularities in shape of the inner wall
surface of a tire rarely occur, and the frequency of exchange can be reduced.
Further, a vulcanizer according to the present invention comprises a bladder
having a magnetic material in at least a part thereof, and being stretched by
a supply of a pressurized medium such as vapor, nitrogen gas, etc. to press
the inner wall surface of a green tire in a mold direction while heating it, and
an induction heating coil for heating the bladder itself by induction heating
the magnetic material of the bladder, wherein since vulcanizing-molding of
the green tire is carried out using the heat quantity of the bladder, the
vulcanizing-molding can be completed in a short period of time.
Patent EP-1061340-A2 (EP)
Inventor: KUNIMATSU YOSHIMASA
IPC: G06F3/0482
Filed: 2000-06-07
Abstract: A display system featuring improved operability
when plural screens are displayed on a display and when
many functions are provided, and a method of display for
the display system. A screen is selected from plural
screens displayed on a display portion 20A of a display 20.
The selected screen is displayed on an entire surface of
the display portion 20A together with an operation menu
corresponding to the selected screen.
Patent EP-1070878-A2 (EP)
Inventor: ONOGI KENKICHI
IPC: F16H63/06
Filed: 2000-07-19
Abstract: In a constant-horsepower transmission having a
primary pulley, a secondary pulley and a belt extended
between the primary and the secondary pulley, a
predetermined frictional force acting between the pulley
and the belt is secured by an external instruction, and the
pulley is capable of automatic alignment and shock
absorption to ensure stable power transmission from the
belt to the pulley. A first compressing device compresses
an elastic device in response to an external instruction, a
first pressing device including the elastic device applies
a pressure and an elastic force produced by the compressed
elastic device to the belt through the pulley. A
predetermined frictional force is secured by the pressure
and stable power transmission is insured by the elastic
force. A first pressure application controller executes a
variable pressure application control operation to apply an
optional pressure to the belt by displacing or not moving
the movable disk of the pulley.
Patent EP-1079305-A2 (EP)
Inventor: NAGAO TAKASHI
IPC: G06F11/34
Filed: 2000-08-25
Abstract: The USB data monitoring apparatus 1 has a synchronization
detection circuit 4 to detect the synchronization pattern and
a completion detection circuit 5 to detect the completion
pattern. According to the synchronization detection signal
outputted from the synchronization detection circuit 4 and the
completion detection signal outputted from the completion
detection circuit 5, a control circuit 7 records only the
effective data of the data signal in the memory 8. At that
time, an idle time measuring circuit 6 records the idle time
just before the data to be recorded is received, in the memory
8, by relating the idle time with the data to be recorded.
Patent EP-1090709-A2 (EP)
Inventor: SIGHINOLFI SERGIO
IPC: B23K26/14
Filed: 2000-09-28
Abstract: An engraving apparatus for engraving a surface (S) by means
of a laser beam, comprises an engraving head (15) suitable
for projecting and focusing, through a suitable opening
(41), a laser beam (F) on said surface (S), said engraving
head (15) being provided with an inner chamber (40)
communicating with said opening (41), the engraving
apparatus further comprises circulating means (43, 44, 45,
46, 47) suitable for circulating a gaseous pressurized fluid
through said chamber (40) and into said opening (41).
Patent EP-1107533-A2 (EP)
Inventor: ASAI RIEKO
IPC: G06F9/50
Filed: 2000-10-19
Abstract: A cluster server apparatus is provided capable of
continuously carrying out data distribution to terminals even if
any cache server is failed, while optimally distributing loads
on a plurality of cache servers. 
     A cluster control unit (21) distributes requests from the
terminals based on the load on each cache server (10 x ). The cache
server (10 x ) distributes, to the terminal (4 y ), requested data
(streaming data) if it is stored in a streaming data storage unit
(14 x ), while distributing data from a content server (30) if it
is not stored therein. Here, the data distributed from the
content server (30) is redundantly stored in the streaming data
storage units (14 x , 14 x+1 ) of two or more cache servers (10 x , 10 x+1 ).
One cache server (10 x ) detects the state of distribution of the
other cache server (10 x+1 , 10 x-1 ) that stores the same data as that
stored in the one cache server (10). If the one cache server (10 x )
becomes unable to carry out distribution, the other cache server
(10 x+1 , 10 x-1 ) continues data distribution instead.
Patent EP-1106475-A2 (EP)
Inventor: KOBAYASHI MASANORI
IPC: B62D5/00
Filed: 2000-11-22
Abstract: When a steering wheel is relatively quickly turned at the
time of parking, before a first stopper mechanism located between
an input shaft and an output shaft is operated, an elastic member
47 attached to a movement end of a rack shaft 13 comes into contact
with a rack stopper 39 of a rack housing 14, thereby absorbing
the impact at the time of steering at parking. That is, the strike
speed when contact portions of the first stopper mechanism are
brought into contact with each other, is slowed down. Accordingly,
the uncomfortable noise due to the strike sound is not given to
the driver.
Patent EP-1043190-A2 (EP)
Inventor: PARKINSON TONY
IPC: B60Q1/26
Filed: 2000-04-03
Abstract: A light bar is formed from three light units (10,
12, 14) each of has a reflector (70) mounted on a rotating
platform 26) having a cylindrical periphery carrying both
gear teeth (28) and a pulley (40) having teeth adapted to
mesh with a toothed belt (48, 50). An electric motor (88)
has a gear (90) on its output shaft engaging with the gear
teeth (28) on the platform (26) of one of the light units.
Toothed belt (48, 50) link the pulleys (40) of adjacent
light units (10, 12, 14).
Patent EP-1058382-A2 (EP)
Inventor: SUZUKI AKIRA
IPC: H03H9/05
Filed: 2000-06-02
Abstract: The invention is directed to piezoelectric device having
a vibration space that achieves a high degree of airtightness
which is not readily reduced, and a manufacturing method
thereof. First and second hollow layers (21) and (31) are formed
at first and second surfaces of a piezoelectric substrate (11)
to form first and second cavities (6) and (7) around first and
second electrodes (12) and (13) respectively. The first and
second cavities (6) and (7) each have a uniform width and
extend between a first surface and an opposing second surface
of the first and second hollow layers (21) and (31) respectively,
around vibration portions of the piezoelectric element (1). First
and second sealing layers (22) and (32) are each formed on
the second surface of the first and second hollow layers (21)
and (31) to seal the first and second cavities (6) and (7).
Patent EP-1102501-A2 (EP)
Inventor: RICHTON ROBERT ELLIS
IPC: H04W4/029
Filed: 2000-11-06
Abstract: A wireless telecommunications system uses location or position information of a
wireless mobile unit to initiate the sending of location-specific information to travelers.
As position information is received, it is compared to prestored position information of a
remote location, such as an airport. As the traveler approaches the remote location, and
gets within a certain distance the remote location, information such as airline arrival
information is retrieved and sent to the wireless mobile unit of the traveler. Thus, useful
information tied to the position of the wireless mobile unit, such as airline or traffic
information for example, is obtained.
Patent EP-1472629-A2 (EP)
Title: Procede de financement de transactions commerciales, instruments et systemes
Inventor: STROH LESLIE
IPC: G06Q40/00
Filed: 2000-03-03
Abstract: La présente invention concerne un procédé simplifié de financement de transactions commerciales notamment en commerce international de biens et services, un  'produit de commerce'' peut utiliser une, et de préférence deux, nouveaux types de lettres de change. Une première lettre de change (l o E), qui est un effet de paiement, est exécutée par un acheteur (B), et renvoyée au vendeur (S) préalablement à la libération du produit de commerce par le vendeur (S). Le vendeur (S) peut obtenir une vérification de crédit de la première lettre de change (l o E), le cas échéant, avant d'expédier le produit de commerce, le vendeur (S) étant ainsi protégé contre tout défaut de paiement de l'acheteur (B). La première lettre de change (l o E) peut demeurer inactive et non négociable jusqu'à qu'elle soit rendue active par un événement, agréé par l'acheteur (B), par exemple, la libération du produit de commerce. Ainsi l'acheteur (B) est protégé contre un retard de la part du vendeur (S) ou un défaut d'expédition du produit de commerce après réception d'un instrument de paiement de la part de l'acheteur (B). Une facture type (PFI) peut être utilisée pour définir les détails de la transaction, et établir les termes du contrat comprenant la possibilité d'éliminer les réclamations de marchandises ou des disputes du cycle de paiement en vue d'une solution selon une convention ou traité international, par exemple la Convention de Vienne sur la Vente Internationale de Biens. Une deuxième lettre de change, d'extinction mutuelle avec la première lettre de change (I o E) peut être utilisée pour faciliter des provisions de crédits par la banque de l'acheteur (BB), évitant ainsi de recourir aux ressources de crédits du vendeur (S).
Patent EP-1210056-A2 (EP)
Inventor: OTTEN GENEVA GAIL
IPC: A45D40/26
Filed: 2000-08-03
Abstract: La présente invention concerne un applicateur semi-ouvert d'apport de substances qui comprend: (a) une structure en trois dimensions possédant des éléments de surface extérieurs destinés à contenir une substance, cette substance ayant un niveau interne par rapport aux éléments de surface extérieurs qui permet de protéger ladite substance contre tout contact par inadvertance avec les surfaces externes, la structure en trois dimensions formant une partie au moins du corps  d'applicateur semi-ouvert possédant au moins une ouverture et une cavité interne; et (b) une substance possédant une résistance sensible au flux en amont de l'apport à une surface cible, qui occupe les espaces de la structure en trois dimensions, la substance restant protégée jusqu'à ce que la structure en trois dimensions est suffisamment déformée pour se transformer en une structure en deux dimensions. La structure est ainsi exposée au contact avec une surface d'un objet, et ce sans que les surfaces soient obligatoirement compatibles; lors de l'activation, la substance possède une viscosité efficace qui permet à ladite substance de se libérer à partir de l'emplacement et d'être distribuée à la surface de l'objet. La substance peut être distribuée vers l'intérieur de l'applicateur, vers l'extérieur de l'applicateur ou encore dans les deux sens. L'applicateur peut avoir la forme d'un gant ou d'une mitaine.
Patent EP-1301539-A2 (EP)
Title: Fragments de liaison a l'antigene specifiques aux cellules dendritiques, compositions et methodes d'utilisation, antigenes ainsi reconnus et cellules ainsi obtenues
Inventor: SCHMITZ JUERGEN
IPC: A61K35/12
Filed: 2000-11-15
Abstract: L'invention concerne des fragments de liaison à l'antigène spécifiques aux cellules dendritiques et efficaces dans le traitement et/ou le diagnostic de troubles divers. L'invention concerne également des méthodes d'utilisation ainsi que des méthodes de criblage de fragments de liaison à l'antigène supplémentaires et les produits ainsi obtenus.
Patent EP-1226177-A2 (EP)
Inventor: DEVAUX BRIGITTE
IPC: C12P21/02
Filed: 2000-10-27
Abstract: The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
Patent EP-1240572-A2 (EP)
Inventor: XYDIS THOMAS
IPC: H04W84/12
Filed: 2000-12-01
Abstract: L'invention porte sur un appareil de sûreté et un procédé permettant de déterminer la distance entre un ordinateur (72) et un jeton (70) porté par un utilisateur (52) et lui permettant d'accéder à l'ordinateur (72). L'ordinateur est relié à un premier émetteur/récepteur (16) comportant au moins une antenne d'émission et de détection d'une fréquence RF et à un microphone (76) de détection d'un signal audio (24). L'ordinateur (72) est également relié à un compteur (26) mesurant l'intervalle de temps (28) séparant le signal RF (20) émis du signal audio (24) du jeton (70). Le jeton (70) est relié à un deuxième émetteur/récepteur (30) comportant au moins une antenne d'émission et de détection d'une fréquence RF, et à un HP (74) émettant un signal audio (24). Le procédé consiste à comparer l'intervalle de temps mesuré (28) à une plage de temps prédéterminée (38), puis à activer l'ordinateur (72) si ledit intervalle tombe dans la plage de temps prédéterminée (38), ce qui permet à l'utilisateur (52) d'avoir accès à l'ordinateur activé (72), ou au contraire à désactiver l'ordinateur (72), si ledit intervalle tombe hors de la plage de temps prédéterminée (38).