Patent SG-11201809729X-A (SG)
Title: Palpable marker composition
Inventor: ANDRESEN THOMAS LARS
IPC: A61K47/26
Filed: 2017-05-19
Abstract: GCr GC GC N O N C () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 November 2017 (23.11.2017) WIPO I PCT omit VIII Hot 0 mu H H mo iflo oimIE (10) International Publication Number WO 2017/198858 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 47/26 (2006.01) (21) International Application Number: PCT/EP2017/062181 (22) International Filing Date: 19 May 2017 (19.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1650695-8 20 May 2016 (20.05.2016) SE (71) Applicants: TECHNICAL UNIVERSITY OF DEN- MARK [DK/DK]; Anker Engelunds Vej 1, 2800 Kgs. Lyn- gby (DK). NANOVI RADIOTHERAPY APS [DK/DK]; Diplomvej 373 N, 2800 Kgs. Lyngby (DK). (72) Inventors: ANDRESEN, Thomas Lars; Krogebjerg 68, 2720 Vanlose (DK). IRMING JOLCK, Rasmus; Bud- dingevej 25B, 2800 Kgs. Lyngby (DK). BRUUN, Linda Maria; Robert Jacobsens Vej 95, 2 TV, 2300 Copenhagen S (DK). (74) Agent: AWAPATENT AB; Box 5117, 200 71 Malmo (SE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: PALPABLE MARKER COMPOSITION Sacrifice Group A Sacrifice Group C: n = 3) n = 3 Injection of Sacrifice G , oup B marker (1 = 3) lh 3fi 24h Figure 1. (57) : The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffmose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body. In another embodiment the composition is a liquid before administration and has the ability to transform into a crystalline or amorphous solid after administration. [Continued on next page] WO 2017/198858 Al MIDEDIM01101 DIDIRMEM1111111111111111111111111H1101111111111111111111 Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))