Patent SG-11201408152V-A (SG)
Title: Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency
Inventor: CLELAND JEFFREY L
IPC: A61K47/42
Filed: 2013-03-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/184216 A1 (51) International Patent Classification: A61K 38/27 (2006.01) A61P 5/00 (2006.01) A61K 47/42 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/689, 390 61/663,475 61/763, 753 PCT/US2013/031673 14 March 2013 (14.03.2013) English English US US us 5 June 2012 (05.06.2012) 22 June 2012 (22.06.2012) 12 February 2013 (12.02.2013) (71) Applicant (for all designated States except US): AMUNIX OPERATING INC. [US/US]; 500 Ellis Street, Mountain View, CA 94043-2206 (US). (72) Inventors; and (71) Applicants (for US only): CLELAND, Jeffrey L. [US/US]; 225 Aberdeen Drive, San Carlos, CA 94070 (US). BRIGHT, George M. [US/US]; 9 Rockwood Court, San Mateo, CA 94403 (US). HUMPHRISS, Eric [US/US]; 550 Morey Drive, Menlo Park, CA 94025 (US). SCHELLENBERGER, Volker [DE/US]; 914 Moreno Avenue, Palo Alto, CA 94303 (US). SILVERMAN, Joshua [US/US]; 829 Dartshire Way, Sunnyvale, CA 94087 (US). STEMMER, Willem P. [NL/US]; 108 Kathy Court, Los Gatos, CA 95051 (US). WANG, Chia-Wei [—/US]; 1449 David Lane, Milpitas, CA 95035 (US). GEETHING, Nathan [US/US]; 213 Cll Zorzal, San Juan, Puerto Rico 00926 (US). SPINK, Benjamin [GB/US]; 379 Northam Avenue, San Carlos, CA 94070 (US). (74) Agents: ORBAI, Lucian et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) V© i-H CJ •t 00 i-H o CJ (54) Title: HGH-XTEN FUSION PROTEIN AND ITS USE IN THE TREATMENT OF GROWTH HORMONE DEFICIENCY (57) Abstract: The present invention concerns an improved therapeutic regimen for GHD therapy. In particular, the invention con­ cerns methods for bolus dose administration of human growth hormone- a XTEN (hGH-XTEN) fusion protein.