Patent SG-11201810521W-A (SG)
Title: Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
Inventor: PRICE DANIEL W
IPC: A61F9/00
Filed: 2017-06-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111110111011111111111M11111001111111 Ill H01111111111111111 1111 III1 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/218610 Al 21 December 2017 (21.12.2017) WIP0 I PCT (51) International Patent Classification: J.; 4545 Creek Road, Cincinnati, Ohio 45242 (US). A61F 9/00 (2006.01) PRENGER, Daniel J.; 10255 Evendale Commons Dri- (21) International Application Number: ve, Cincinnati, Ohio 45241 (US). KING, Geoffrey; 10255 PCT/US2017/037361 Evendale Commons Drive, Cincinnati, Ohio 45241 (US). MEYER, Thomas E.; 205 West 4th Street, Suite 1140, (22) International Filing Date: Cincinnati, Ohio 45202 (US). KO, Benjamin L.; 205 West 14 June 2017 (14.06.2017) 4th Street, Suite 1140, Cincinnati, Ohio 45202 (US). (25) Filing Language: English (74) Agent: SHIRTZ, Joseph F. et al.; JOHNSON & (26) Publication Language: English JOHNSON, One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/351,611 17 June 2016 (17.06.2016) US kind of national protection available): AE, AG, AL, AM, 15/609,386 31 May 2017 (31.05.2017) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (71) Applicant: JANSSEN BIOTECH, INC. [US/US]; CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (US). HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (72) Inventors: PRICE, Daniel W.; 4545 Creek Road, Cincin- MG, MK, MN, WV, MX, MY, MZ, NA, NG, NI, NO, NZ, nati, Ohio 45242 (US). OBERKIRCHER, Brendan DELIVERY OF THERAPEUTIC AGENT (54) Title: APPARATUS AND METHOD TO FORM ENTRY BLEB FOR SUBRETINAL = = = 26 30 - = 40 24 = = = = = ----- -. = 24 = — : - _ ) = = = _ = = _ 1 Fig®1 1 (57) : An apparatus includes an injector (10), a first fluid conduit (422), a second fluid line (424), and a control module (500). 1-1 The injector includes a body (20), a flexible cannula (50), a flexible needle (100), and a sensor (660). The needle is configured to GO translate relative to the cannula. The sensor is operable to detect a position of the needle relative to the cannula. The first and second 1-1 fluid lines are coupled with the needle. The control module is in communication with the sensor, with the first fluid conduit, and with ei ---- the second fluid conduit. The control module is configured to provide delivery of a first fluid (340) through the first conduit to the IN needle based on a signal from the sensor. The control module is further configured to provide delivery of a second fluid (341) through © the second conduit to the needle. ei O [Continued on next page] WO 2017/218610 Al MIDEDIMOMOIDEIRMEM00111111111111111111110111110111111111111 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))