baber/WOPTO huggingface dataset:
Patent JP-2001514511-A (JP)
Title: 核酸への親和性を持つ化合物同定のための蛍光異方性を用いたスクリーニング
IPC: C12Q1/6813
Filed: 1998-03-05
Abstract: (57)【要約】
本発明は、生物活性化合物、特に、疾患の病原または生理機能の調節に含まれるＲＮＡ配列に結合するものをスクリーニングする方法を提供する。この方法は、試験リガンドの存在下及び不存在下でのＲＮＡ標的の安定性及び／またはコンホメーションを評価し、標的ＲＮＡの安定性及び／またはコンホメーションにおいて測定可能な変化を生じた任意の試験リガンドをリガンドとして同定することを含む。好ましい実施態様では、リガンドの標的ＲＮＡ安定性及び／またはコンホメーションに対する影響は、蛍光ラベルされたプローブの蛍光偏向を測定することにより評価される。
Patent JP-2000509534-A (JP)
Title: コンピュータシステム内のプログラム、ファイル及びデータを組織化して実行するナビゲーションためのユーザインターフェース
IPC: G06F3/0482
Filed: 1997-04-25
Abstract: (57)【要約】
第１のウィンドウ（１１１）、第２のウィンドウ（１１３）、第３のウィンドウ（１１２）を、仮想平行六面体の４面のうちの３面に配置し、コマンドを入力するための選択可能な選択部を、上記各ウィンドウ（１１１、１１２、１３）に配置し、上記第１のウィンドウ（１１１）が選択されたときに、上記表示装置の中央付近に上記第１のウィンドウ（１１１）を表示するとともに、上記表示装置の右側及び左側に、それぞれ、上記第２のウィンドウ（１１３）及び第３のウィンドウ（１１２）の少なくとも一部を表示するグラフィカルユーザインターフェース（１０３）。ユーザは、あたかも仮想平行六面体の中に立っているかのように感じ、表示メニューをさらに容易に理解することができるので、この三次元インターフェース（１０３）を介してコマンドを迅速且つ確実に入力することができる。
Patent JP-2000511629-A (JP)
Title: リガンドの開発および多変量タンパク質化学最適化のためのマイクロプレート熱シフトアッセイおよび装置
IPC: C12Q1/6811
Filed: 1997-05-09
Abstract: (57)【要約】
本発明は、熱変化によって変性し得る標的分子に対する複数の異なる分子の親和性をランク付けするための方法である。この方法は、複数の容器の各々における複数の異なる分子の１つの分子に標的分子を接触させる工程、複数のコンテナーを同時に加熱する工程、コンテナーの各々の加熱から生じる標的分子の熱変性に伴う物理学的変化を測定する工程、コンテナーの各々についての温度を関数として標的分子についての熱変性曲線を作製する工程、およびそれから中点温度(T m )を決定する工程、各々の熱変性曲線のT m を複数の異なる分子の任意の分子の非存在下で標的分子について得られた熱変性曲線のT m とを比較する工程、および各々の熱変性曲線におけるT m の変化に従って、複数の異なる分子の親和性をランク付けする工程、を含む。本発明はまた、複数のサンプルを同時に加熱するための温度調節手段、およびサンプルが加熱されている間のサンプルからの発光スペクトルを受容するための受容手段を含むアッセイ装置を提供する。本発明のさらなる局面において、受容手段はサンプルからの蛍光発光、紫外線光、および可視光を受容するように構成され得る。受容手段は、種々の方法（例えば、一度に１つのサンプル、１つ以上のサンプルから同時に、または全てのサンプルから同時）においてサンプルからのスペクトル発光を受容するように構成され得る。温度調節手段は、所定のプロフィールに従って温度を変化させるための温度制御器を有して構成され得る。
Patent JP-2001522525-A (JP)
Title: 絶縁電力ケーブル
IPC: H01B9/02
Filed: 1999-02-22
Abstract: (57)【要約】
絶縁層（１２;２２）と１つ以上の半導電層（１１;１３;２１;２３）を有する絶縁システムを具備する絶縁電力ケーブル。絶縁層は電気絶縁性のポリマー組成物からなり、極性材料を増加させた増大した極性を有する表面領域を有する。発明に基づくケーブルは特に電力の送電又は配電システムあるいは高電圧機器の高圧配線に好適に使用することができる。
Patent JP-2001523967-A (JP)
Title: 結晶化方法
IPC: C13B30/02
Filed: 1998-05-04
Abstract: (57)【要約】
本発明は溶解された乾燥固体でキシロースを３０重量％以上含有するキシロース含有水溶液からキシロースを回収する方法に関する。該溶液は低圧でキシロースに関して過飽和の溶液まで蒸発され、その溶液に種晶が添加され、そしてキシロース収率が１ないし６０％である結晶マスが得られるまで、蒸発が溶液の沸点で継続され、そしてキシロースが回収される。
Patent JP-2000513498-A (JP)
Title: 幾何学的放電分布に合わせた蛍光体層厚さを有する蛍光ランプ
IPC: H01J61/42
Filed: 1999-04-09
Abstract: (57)【要約】
部分放電のパターンにより輝度変化に合わせた蛍光体層厚さ変化部を有する、特に液晶表示スクリーンのバックライト用の蛍光ランプが記載される。
Patent JP-2002506610-A (JP)
Title: 予め母線化された剛性導管配電システム
IPC: H02G3/00
Filed: 1999-04-23
Abstract: (57)【要約】
電源地点から使用地点または配電地点まで電力を搬送するセクション化された配電システム。配電システムの各セクションが、手のこで容易に切断可能な円筒形外郭を含んでいる。この外郭は、また外郭内に配置された複数電気導体を支持し、且つ該電気導体を物理的損傷から保護している。電気導体は、外郭内に滑りばめされた連続的な絶縁支持体によって定位置にしっかりと保持されている。各導体は、金属切断用手のこによって容易に切断することができる。
Patent MX-157744-A (MX)
Inventor: SCHMITT WILHELM
IPC: F16J15/328
Filed: 1983-06-15
Abstract: A method of making a shaft seal ring starts with a tube, optionally provided on its outside and/or inside with hydrodynamically-acting return elements, as may be cut from a hollow cylinder. The tube is axially slipped along a form with a continuously increasing diameter until its leading or lower end is shaped into a flange in the radial direction. The flange may be simultaneously joined to a reinforcing ring.
Patent MX-159279-A (MX)
Inventor: BREDMAN HENRY S
IPC: A61N1/372
Filed: 1983-12-21
Abstract: A stimulator (10) for penile erection comprises a body member (12) which may be inserted into the rectum (14) of a user, the body member being so shaped as to closely conform to the topological configuration of the rectum from the anal area to a site adjacent to the prostate gland (26). Within the body member is electrical circuitry for generating a neurally stimulating electrical signal. Electrodes (16,18,20, 22), placed at particular locations on the surface of the body member, apply the signal to the user. At least one of the electrodes (22) closely contacts the prostate gland when the body member is operatively disposed, at a region or spot (58) on the prostate gland previously determined to be sensitive to electrical stimulation. Also disclosed is a method for making the aforesaid body member by taking an impression of the rectum of the user, and a method for inducing penile erection which includes the steps of locating sensitive regions or spots on the prostate gland, and applying electrical stimulation directly to those spots so as to induce erection.
Patent NZ-196797-A (NZ)
Title: Wood preservative containing alkyd resin and fungicide or insecticide
Inventor: MARX H
IPC: C09D5/14
Filed: 1981-04-13
Abstract: A wood preservative which consists of an aqueous solution containing both an alkyd resin and a fungicidal or insecticidal active ingredient, namely 2,5-dimethylfuran-3-carboxylic acid N-methoxy-N-cyclohexylamide, tributyl-tin benzoate, tributyl-tin naphthenate, gamma-hexachlorocyclohexane, pentachlorophenol laurate, 2-methoxycarbonylamino-benzimidazole or a mixture of these active ingredients.
Patent NZ-201250-A (NZ)
Title: Microprocessor control of power supplied to electrostatic dust separator
Inventor: GUSTAFSSON A G
IPC: B03C3/68
Filed: 1982-07-13
Abstract: A control device for an electrostatic dust separator (10, 11) intended to control in relation to the recorded level of direct current (104) and direct current voltage (102) in the dust separator and with the help of the supply voltage (6a) passes through the zero point the switching in and/or out of the rectifiers (8, 8a) wired into the power supply lead (6a) to the dust separator, usually in the form of two thyristors. The recorded value for the current (104) and the recorded value for the voltage (102) together with the information in respect of the passage through zero of the supply voltage (100) are connected directly via conversion circuits (25, 26) to a data processing unit (112). This (112) is so arranged that in relation to the value (102,104) of the actual direct current and direct current voltage in the dust separator and with reference to the passages through zero (100) it will on the one hand calculate a specific time interval for the switching in and/or switching out of the rectifier (8) from the power supply and on the other hand generate switching-in and switching-out pulses (112a, 112b). These switching-in and switching-out pulses are fed directly, via adapter circuits, from the data processing unit.
Patent NZ-206543-A (NZ)
Title: Photomultiplier tube: reduced light measurement errors
Inventor: THOMPSON R A
IPC: G01M3/38
Filed: 1983-12-09
Abstract: A photomultiplier tube assembly for use in high speed light testing apparatus for making a series of light measurements in rapid succession. Electronic circuitry is described for removing noise from a light measurement signal generated by the photomultiplier tube. Other circuitry is described for sensing the presence or absence of a measured object in a testing apparatus and for switching the photomultiplier tube on and off in response thereto. Circuitry for generating a signal to reject defective articles subsequent to testing is described.
Patent NZ-206705-A (NZ)
Title: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acid derivatives and pharmaceutical compositions
Inventor: PETERSEN U
IPC: C07D401/04
Filed: 1983-12-23
Abstract: The invention relates to 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)quinol ine-3-carboxylic acids of Formula (I), processes for their manufacture, compositions containing them and use of said compounds and compositions as antibacterial and/or feedstuff additives.
Patent NZ-208514-A (NZ)
Title: Water purifier uses ion injection
Inventor: HAYES J
IPC: C02F1/46
Filed: 1984-06-14
Abstract: This invention concerns apparatus which is adapted to purify water by the introduction of metal ions into the water. A chamber is provided which houses two electrodes which are made of metals whose ions are known to have water-purification properties. Water to be purified is passed through the chamber, whereupon a controlled concentration of purifying ions are passed into the water. The metal ions preferably include silver and/or copper to control respectively bacteria and algae. Furthermore, in order to minimise adverse electrolytic effects it has been found advantageous to reverse the polarity of the potential difference across the electrodes at regular intervals.
Patent NZ-211513-A (NZ)
Title: Anti-fouling paint containing toxicant and seawater-erodible polymer binder
Inventor: GITLITZ M H
IPC: C08F8/14
Filed: 1985-03-20
Abstract: The present invention relates to a novel polymeric binder for use in an antifouling paint which includes a toxicant. The polymeric binder is film-forming, water insoluble, seawater erodible and is represented by the formula 
<CHEM>
 wherein, in one embodiment,
 X is H or CH3;
 M is from greater than 2.5 to less than 25 mole percent of a saturated residue of a tributyltin acrylate or methacrylate group;
 R is a substantially non-bioactive, substituted alkyl, aryl or arylalkyl moiety; and
 recurring groups B, where B is the residue of an ethylenically unsaturated monomer. 
<??>The polymer has a hydrolysis rate of at least 5x10<4> milliequivalents per hour. The resultant paint has an erosion rate of at least 2 microns per month. 
<??>R can be selected from the group consisting of: 
<CHEM>
 wherein
 Z is NO2, halogen or CN; V is H, NO2, halogen, CN, alkoxy; b) -(CH2)nY
 wherein
 n is an integer from 1 to 4; and
 Y is selected from the group consisting of 
<CHEM>
 and wherein
 R min  is C1 to C4 primary, secondary or tertiary alkyl,
 R sec  is H or R min ;
 R''' is alkyl or an aryl;
 c) can be -SiR3''' or -Si(OR''') 3;
 d) R can be a haloalkyl group having at least one trihalomethyl group where the halogen is Br, F, Cl, and the alkyl has at least two carbon, e.g. trifluoroethyl acrylate;
 e) a quaternized aminoalkyl represented by the formula 
<CHEM>
 where Y is Br, Cl or I,
 R min , R sec  and R''' are the same or different C1 to C18 alkyls.
Patent NZ-224100-A (NZ)
Title: Naphtho(2,3-b)furans and benzocyclohepta(2,3-b)furans and pharmaceutical compositions
Inventor: PEGLION JEAN LOUIS
IPC: C07D307/93
Filed: 1988-03-31
Abstract: Compounds of the general formula I   <IMAGE>   in which R1 and R2, which may be identical or different, each denote a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical or a linear or branched alkyl radical containing from 1 to 10 carbon atoms, optionally substituted with a hydroxy radical, with a carboxy radical or with an alkoxy radical having 1 to 5 carbon atoms, with an alkoxycarbonyl radical having 2 to 6 carbon atoms, with an alkylphenyl radical having 7 to 16 carbon atoms or with a 2-alkylthienyl radical having 5 to 14 carbon atoms, R3 denotes a hydrogen atom or a linear or branched alkyl radical containing from 1 to 4 carbon atoms, A denotes a single bond or a methylene radical, or a radical of formula <IMAGE>   in which R4 is a linear or branched alkyl radical containing from 1 to 4 carbon atoms. These products are useful in anti-depressant, anti-aggressive, or dopaminergic modulation therapy and the corresponding bicyclic compounds are useful as intermediates for ring closure and production of the tricyclic compounds having the foregoing formula.
Patent NZ-225561-A (NZ)
Title: 2,2'-bi-1h-imidazole derivatives and pharmaceutical compositions
Inventor: MATTHEWS DONALD P
IPC: C07D417/14
Filed: 1988-07-26
Abstract: This invention relates to novel (aryl or heteroaromatic methyl)-2,2 min -1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2 min -bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
Patent NZ-227732-A (NZ)
Title: Substituted quinolines and cinnolines, and insecticidal, miticidal and fungicidal compositions
Inventor: DREIKORN BARRY ALLEN
IPC: C07D215/22
Filed: 1989-01-25
Abstract: Compounds of the formula (1): <CHEM>  wherein:  R<1> to R<4> are independently H, halo, (C1-C4) alkyl, branched (C3-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, NO2, or NH2, at least two of R<1> to R<4> being H, or one of R<2> to R<4> is -NR<7>-Y-Ar or O-Y-Ar and the rest of R<1> to R<4> are H;  W is N, or CR<5>;  R<5> is H, CH3, Cl, O-Y-Ar, or -NR<7>-Y-Ar;  R<6> is H, CH3, Cl or Br;  A is -O-Alk or -X-Y-Ar; Alk is a C2-C18 saturated or unsaturated hydrocarbon chain, straight chain or branched, optionally substituted with halo, halo (C1-C4) alkoxy, (C3-C8) cycloalkyl, hydroxy, or acetyl; X is O, NR<7>, or CR<8>R<9>, provided that if one of R<2> to R<5> is NR<7>-Y-Ar or O-Y-Ar, then X-Y-Ar is an identical group;  R<7> is H, (C1-C4) alkyl, or acetyl; R<8> and R<9> are independently H, (C1-C4) alkyl, (C1-C4) acyl, halo, or OH, or R<8> and R<9> combine to form a saturated or unsaturated carbocyclic ring comprising three to seven carbon atoms; Y is an alkylene chain 2 to 8 carbon atoms long, optionally including an O, S, SO, SO2, or NR<7> group or a saturated or unsaturated carbocyclic ring comprising three to seven carbon atoms, or substituted with (C1-C3) alkyl, (C2-C4) alkenyl, phenyl, (C3-C8) cycloalkyl, hydroxy, halo, or (C1-C4) acyl; and  Ar is  1,3-benzodioxolyl  fluorenyl,  pyridyl,  imidazolyl,  indolyl,  thienyl, optionally substituted with CH3 or Cl,  thiazolyl,  cyclopentyl,  1-methylcyclopentyl,  cyclohexenyl (hexahydrophenyl),  cyclohexyl (tetrahydrophenyl),  naphthyl,  dihydronaphthyl,  tetrahydronaphthyl,  decahydronaphthyl, or  a group of the formula (2): <CHEM>  where R<1><0> to R<1><4> are independently H, halo, I, (C1-C10) alkyl, branched (C3-C6) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl, substituted phenyl, NO2, NH2, acetoxy, OH, CN, or SiR<1><5>R<1><6>R<1><7>, OSir<1><5>, R<1><6>, R<1><7>, where R<1><5>, R<1><6>, and R<1><7> are independently (C1-C4) alkyl or (C3-C4) branched alkyl, provided that unless each of R<1><0> to R<1><4> is F, CH3, or H, then at least two of R<1><0> to R<1><4> are H;  or an acid addition salt of a compound of formula (1)  or an N-oxide of a compound of formula (1) when W is CR<5> are fungicides, insecticides, and miticides.
Patent NZ-228610-A (NZ)
Title: Page mode memory addressing
Inventor: BLAND PATRICK MAURICE
IPC: G06F13/36
Filed: 1989-04-04
Abstract: A computer system includes a page memory in which a row address accompanied by a row address strobe (RAS) is followed by a column address accompanied by a column address strobe (CAS) to read data from a memory location during a memory cycle. When, in a following memory cycle, a further location from the same page is to be accessed, the row address and the RAS remain constant and a new column address is used with the CAS being precharged by switching it to its OFF state and then returning it to its ON state. This is normally done at the start of the following memory cycle. In the present system, the data is read and latched shortly after arrival of the column address and CAS in the first of the memory cycles so that the CAS recharge can take place at the end of the first memory cycle and before the start of the following memory cycle.
Patent NZ-236179-A (NZ)
Title: Compositions comprising tebufelone (1-(3,5-di-tert-butyl-4-hydroxyphenylhex-5-yn-1-one) and at least one surface active compound, the carrier being an homogeneous liquid at 37 o c
Inventor: KELM GARY ROBERT
IPC: A61P25/04
Filed: 1990-11-21
Abstract: The subject invention involves compositions consisting essentially of the drug active 1-3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl-5-hexyn-1-one (tebufelone) at a concentration of at least about 15%, and the balance a pharmaceutically-acceptable vehicle. The vehicle is formulated such that the compositions are homogeneous liquids at 37 DEG C and provide good solubilization of the drug active.
Patent NZ-268405-A (NZ)
Title: Atp-adp chemiluminescent testing for microorganisms including a source of a magnesium ion
Inventor: SQUIRRELL DAVID JAMES
IPC: G01N33/557
Filed: 1994-07-13
Abstract: A method for determining the presence and/or amount of microorganisms and/or their intracellular material present in a sample comprising estimating the amount of adenylate kinase therein by its ability to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) in the presence of added magnesium ions and relating that to the presence/or amount or organism and/or intracellular material. The method provides improved sensitivity over existing luciferase/luciferin assays. Reagents including purified ADP and adenylate kinase free luciferase are provided together with test kits including these and apparatus for automated operation of the method.
Patent NZ-272564-A (NZ)
Title: Multiwavelength doped optical fibre amplifier and communication system with wavelength division multiplexing
Inventor: MELI FAUSTO
IPC: H04B10/43
Filed: 1995-07-13
Abstract: An optical telecommunication system comprising a transmitting station and a receiving station for optical signals, connected with each other by an optical fibre line including optical line amplifiers having a rare-earth-doped active fibre and connected in series, in which the transmitting station comprises generation means for generating signals at several predetermined wavelengths, and conveyor means for conveying said signals to a single optical fibre line, and said optical signal receiving station comprises separation means for separating said signals, in which at least one of said optical line amplifier has dopants, fibre length and pumping power capable of determining, at the input of the receiving station, an optical signal/noise ratio which between the different wavelengths has a difference lower than 2 dB, and for each signal is greater than 15 dB. <MATH>
Patent NZ-302207-A (NZ)
Title: Biomass waste gasifier with fumes passing from primary chamber to afterburner chamber and then to heat transfer chamber
Inventor: BROOKES DAVID
IPC: F23G7/10
Filed: 1996-03-06
Abstract: A gasifier is disclosed. The gasifier comprises a primary chamber for receiving therein biomass waste material and other related volatile solids to be gasified. A fume transfer vent permits the escape of fumes from the primary chamber. A mixing chamber accepts the fumes from the fume transfer vent. The fumes then flow to an afterburner chamber where a burner member produces a heating flame so as to cause the additional full oxidization of the constituents of the fumes so as to oxidize the constituents. A partitioning wall is disposed between the flame chamber and the primary chamber so as to preclude the heating flame from entering the primary chamber and to also preclude the radiation from the heating flame from directly entering the primary chamber, thereby precluding direct contact and physical disturbance of the waste material. A heat transfer chamber in fluid communication with the afterburner chamber accepts the fully oxidized fumes therefrom. The heat from the full oxidation of the fumes causes heating of the heat transfer chamber. The primary chamber has a heat conductive floor and is superimposed on the heat transfer chamber with the heat conductive floor being disposed in separating relation therebetween so as to permit conductive and convective heating of the primary chamber, thus causing heating of the waste in the primary chamber. An exhaust vent in fluid communication with the heat transfer chamber permits venting the fumes to the ambient surroundings.
Patent NZ-329156-A (NZ)
Title: A method of treating harmful effects of an endogenous HGF using a modified HGf which in non-glycosylated
Inventor: VADAS MATHEW ALEXANDER
IPC: A61K38/19
Filed: 1997-11-11
Abstract: This use of a modified HGF (haemopoietic growth factor) is in medicaments for ameliorating the aberrant effects of an endogenous HGF in a mammal.  The modified HGF used is characterised by being in an unglycosylated form and comprising a sequence of amino acids within a first a-helix where one of the amino acids having acidic properties is substituted with a basic amino acid residue.
Patent NZ-336059-A (NZ)
Title: Slide fastener for plastic bag, interlocking profiled strips have attached ribbons, slider hooks over free ends of ribbons
Inventor: VAN ERDEN DONALD L
IPC: B65D33/25
Filed: 1999-06-01
Abstract: A slide fastener for a plastic bag includes profiled interlocking strips 12, 14 attached to webs 18, 24.  Ribbons 16, 22 are attached to the webs.  The webs are attached to the sidewalls of a bag.  One strip 12 has two hooked arms 26, 28, with the hooks 30, 32 facing away from each other.  The other strip also has two hooked arms 44, 46, with the hooks facing towards each other.  When the fastener is in the closed position, the arms 26, 28 interlock within the arms 44, 46. A slider fits over and around the strips, and has a separator that disengages the interlocking strips when the slider is slid along the strips.  The slider hooks under the free ends 23, 17 of the ribbons 16, 22.
Patent NZ-336629-A (NZ)
Title: Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
Inventor: BROWN MATTHEW FRANK
IPC: C07D307/84
Filed: 1998-02-05
Abstract: The compound of formula (I) wherein: R1 is (C2-C9) heteroaryl optionally substituted or naphthalene-2-yl. R2 is phenyl-(CH2)m-, naphthyl-(CH2)m-, (C3-C10)cycloalkyl-(CH2)m-, (C1-C6)alkyl or (C2-C9)heteroaryl-(CH2)m-, wherein m is an integer from 0 to 4 wherein each of said phenyl, naphthyl, (C3-C10)cycloalkyl or (C2-C9)heteroaryl moieties may be optionally substituted. R3 is hydrogen, (C1-C10) alkyl, (C3-C10) cycloalkyl-(CH2)n-, (C2-C9)heterocycloalkyl-(CH2)n-, (C2-C9)heteroaryl-(CH2)n or aryl-(CH2)n wherein n is an integer from 0 to 6 and wherein the (C1-C10)alkyl group, the (C3-C10)cycloalkyl moiety, the (C2-C9)heterocycloalkyl moiety, the (C2-C9)heteroaryl moiety or the aryl moiety may be optionally substituted. R4 is hydrogen, (C1-C6) alkyl, hydroxy, (C1-C6) alkoxy, hydroxy (C1-C6 ) alkyl, (C1-C6)alkoxy(C=O)-, (C3-C10)cycloalkyl-(CH2)p-, (C2-C9)heterocycloalkyl-(CH2)p-, (C2-C9)heteroaryl-(CH2)p- phenyl-(CH2)p-, or naphthyl-(CH2)p wherein p is an integer 0 to 4 and the (C2-C9)heterocycloalkyl, (C2-C9)heteroaryl, phenyl and naphthyl groups may be optionally substituted. R4 and R5 together with the nitrogen atom to which they are attached form a (C2-C9)heterocycloalkyl group wherein any of the ring atoms may be optionally substituted. R5 is hydrogen, (C1-C6) alkyl or amino. R6 is hydrogen,  (C1-C6)alkyl, (C1-C6)alkoxy-(CH2)g-, (C1-C6)alkoxy(C=O)-(CH2)g-, (C1-C6)alkyl-(SO2)-(CH2)g-, (C6-C10)aryloxy-(CH2)g-, (C6-C10)aryloxy(C=O)-(CH2)g-, and (C6-C10)aryl-(SO2)-(CH2)g-, wherein g is an integer from 1 to 4. Providing that when either R4 or R5 is hydrogen and the other of R4 or R5 is (C1-C6) alkyl or morpholinoethyl, R2 is (C3-C10) cycloalkyl or isopropyl and R3 is (C3-C5) alkyl, phenyl, methylvinyl, dimethylvinyl, halovinyl, hydroxy (C1-C3) alkyl or amino (C1-C4) alkyl or amino (C1-C4) alkyl then R1 must be other than indol-5-yl, 6-azaindol-2-yl, 2,3-dichloro-pyrol-5-yl, 4-hydroxyquinolin-3-yl, 2-hydroxyquinoxalin-3-yl, 6-azaindolin-3-yl or optionally substituted indol-2 or 3-yl. Providing that when R5 is hydrogen, then R4 must be other than pyrazolyl, isoxazolyl, imidazolylmethyl, thiazolyl, thiazolylmethyl, triazolyl, tetrazolyl or oxazolylmethyl. And the pharmaceutically acceptable salts of the compound. Also described are pharmaceutical composition comprising the compound of formula (I). The compounds of formula (I) are useful for autoimmune diseases, acute and chronic inflammatory conditions, allergic conditions, infection associated with inflammation, viral, transplantation tissue rejection, atherosclerosis, restenosis, HIV infectivity and glaucomatous.