Patent SG-11201500025X-A (SG)
Title: Process for preparing n-acyl amino acid salts
Inventor: WANG BING
IPC: C07C231/02
Filed: 2013-06-27
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/008103 A1 (51) International Patent Classification: C07C 231/02 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/048341 27 June 2013 (27.06.2013) English English (30) Priority Data: 61/667,568 3 July 2012 (03.07.2012) (71) Applicant: STEPAN COMPANY [US/US]; 22 W. Front­ age Road, Northfield, IL 60093 (US). (72) Inventors: WANG, Bing; 7800 N. Nordica Avenue 2a, Niles, IL 60714 (US). DADO, Gregory, P.; 3520 N. Lake Shore Drive.,Apt 1M, Chicago, IL 60657 (US). (74) Agent: SCHUCHARDT, Jonathan, L.; Dilworth IP, LLC, 2 Corporate Drive, Suite 206, Trumbull, CT 06611 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Ug (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) o i-H 00 o o o CJ o & (54) Title: PROCESS FOR PREPARING N-ACYL AMINO ACID SALTS (57) Abstract: Improved processes for making an N-acyl amino acid salt from fatty a alkyl ester or a polyol ester are disclosed. Each process uses polyol a selected from glycerin or propylene glycol in an amount effective to keep the reaction mixture fluid until con­ version to the N-acyl amino acid salt reaches the desired level of completion. In one process, fatty a alkyl ester reacts with an amino acid salt in the presence of glycerin or propylene glycol to produce an N-acyl amino acid salt. In another process, a polyol ester re­ acts with the amino acid salt in the presence of added glycerin or propylene glycol to produce the N-acyl amino acid salt. We sur - prisingly found that an effective amount of glycerin or propylene glycol minimizes or eliminates reaction mixture solidification or foaming, reduces color, and minimizes the level of di- and tripeptide by- products. In a related process, water added is when conver­ sion of the amino acid salt to the N-acyl amino acid salt is in the range of 50 to 90 mole %. Water addition improves processability, advances conversion without producing excessive soap, and helps to ensure that the N-acyl amino acid salt will have low color and a small proportion of by-products.