baber/WOPTO huggingface dataset:
Patent CA-2439899-A1 (CA)
Title: Improved skin substitutes and uses thereof
Inventor: HOFFMANN MICHAEL
IPC: C12Q1/68
Filed: 2002-03-01
Abstract: The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved barrier function is a result of improved culture conditions, while in other embodiments, improved barrier function results from genetic modification of keratinocyts. Improved culture conditions to improve barrier function include organotypic culture in the presence of linoleic acid and/or linoleic acid at about 75% humidity. Suitab le genetic modifications for improving barrier function includes transfection with a DNA construct capable of expressing GKLF. The present invention furth er provides improved methods of using such skin substitutes in the screening of compounds for irritancy activity, as well for identifying novel irritant responsive genes.
Patent CA-2440647-A1 (CA)
Title: P-thienylbenzyl-amides serving as agonists of angiotensin-(1-7)-receptors, method for the production thereof, their use and pharmaceutical preparations containing the same
Inventor: HEITSCH HOLGER
IPC: A61P9/10
Filed: 2002-03-06
Abstract: The invention relates to p-thienylbenzyl-amides of formula (I), in which R(1), R(2), R(3), R(4), R(5), R(6) and X have the meanings as cited in the description. The compounds of formula (I) constitute potent agonists of angiotensin-(1-7)-receptors. Due to the stimulation of these receptors caused by the compounds of formula (I), and to the production and release, on endothelial cells, of the vaso-relaxing and cardioprotective messengers cyclic guanosine monophosphate (cGMP) and nitrogen monoxide (NO), said production and release being associated with the stimulation of said receptors, the compounds of formula (I) are suitable for use as valuable medicament active substances for treating and preventing hypertension, cardiac hypertrophy, cardiac power failure, coronary heart diseases such as angina pectoris and endothelial dysfunction or endothelial damages, e.g. as a consequence of arteriosclerotic processes or in the case of diabetes mellitus.
Patent CA-2440924-A1 (CA)
Title: Construct for buildings and method for manufacturing the same
Inventor: HIRAGAKI MINORU
IPC: B23K9/028
Filed: 2003-09-16
Abstract: A construct for buildings includes a steel pipe member and reinforcing elements crossing the interior of the pipe member in the longitudinal direction. Holes for the reinforcing elements are formed at mounting positions for the reinforcing elements on an outer peripheral portion of the pipe member having a width meeting width dimensions of the reinforcing elements. The reinforcing elements are inserted through the holes from the outer peripheral surface of the steel pipe member to the interior in a direction that is substantially orthogonal to the longitudinal axis of the steel pipe member
Patent CA-2441185-A1 (CA)
Title: Double metal cyanide catalysts which can be used to prepare polyols and the processes related thereto
Inventor: WANG WEI
IPC: B01J27/26
Filed: 2003-09-17
Abstract: The present invention is directed to double metal cyanide catalysts ("DMC") which can be used to prepare polyols. DMC catalysts of the present invention are prepared by combining i) at least one metal salt; ii) at least one metal cyanide salt; iii) at least one organic complexing ligand; iv) at least one alkaline metal salt; and, optionally, v) at least one functionalized polymer. The present invention is also directed to a process for preparing a polyol in the presence of a DMC catalyst of or prepared according to the present invention.  Surprisingly, DMC catalysts of the present invention, which are preferably prepared with at least one alkaline metal halide, have acceptable activity and can be used to catalyze oxyalkylation reactions. Additionally, DMC catalysts produced by the process of the present invention can be used to prepare polyols which have reduced levels of high molecular weight tail.
Patent CA-2442031-A1 (CA)
Inventor: MUNDILL PAUL HENRY CHARLES
IPC: G01N33/53
Filed: 2002-03-04
Abstract: Disclosed is a method of assessing the fertility status of a human female subject, the method comprising the steps of; (a) testing the concentration of FSH in each of a plurality of urine samples obtained from the subject, each sample being obtained on a different day of a first menstrual cycle in the subject; (b) testing the concentration of FSH in each of plurality of urine samples, each sample being obtained on a different day in one or more subsequent menstrual cycles in the subjects; (c) comparing the FSH test results obtained from the subject with a reference value calculated from a control population; and, (d) based at least partly on the comparison, making an assessment of the fertility status of the subject.
Patent CA-2442694-A1 (CA)
Title: Osteoprotegerin in milk
Inventor: VIDAL KARINE
IPC: A23L1/305
Filed: 2002-03-15
Abstract: The present invention pertains to osteoprotegerin obtainable from milk sources, in particular human and bovine milk. The present invention also relates to the use thereof for preparing an ingestible preparation and/or a pharmaceutical composition, in particular to the use of such a preparation/composition for preventing or treating disorders associated with bone metabolism and immune function.
Patent CA-2444583-A1 (CA)
Inventor: HUNTER JACK H
IPC: B05B7/08
Filed: 2002-04-11
Abstract: The present invention relates to a spray nozzle for a two-component, air assisted, low-pressure spray system including a) a static mixer (1) having a n inlet port on its upstream end for receiving a first liquid component and a second liquid component that is reactive with the first liquid component and having on its downstream end an optionally removable spray tip (5) for introducing the mixed liquid components into an atomizing zone (16), b) a static mixer shroud (7), which encases the static mixer (1), is dimensioned on its upstream end for connecting the shroud to a dispensing unit for the firs t and second liquid components and has on its downstream end an optionally removable spray section (10) having inlet ports for receiving pressurized ai r and outlet ports (18) for introducing air into the atomizing zone, wherein t he spray tip (5) passes through an orifice in the spray section (10) such that the mixed liquid components are introduced into the atomizing zone (16). The present invention also relates to a process for spraying a two-component composition using the spray nozzle.
Patent CA-2449843-A1 (CA)
Inventor: TOMPKINS EILEEN VALENZUELA
IPC: C07D405/14
Filed: 2002-06-05
Abstract: Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
Patent CA-2452771-A1 (CA)
Title: Procede de fabrication d'une ailette allongee et decalee
Inventor: GRANETZKE DENNIS C
IPC: F28F3/02
Filed: 2002-08-21
Abstract: La présente invention concerne un procédé de formation des ailettes de tubes d'échangeur de chaleur qui élimine les vitesses de production lentes desdites ailettes. Dans ce procédé, on utilise une pluralité d'ensembles cylindres (60, 62, 64, 66, 68, 70) situés le long d'un chemin de formage qui peuvent opérer sur une bande (56) de matière de formation d'ailettes d'une longueur indéterminée. Une fois formée, l'ailette peut être coupée à n'importe quelle longueur désirée.
Patent CA-2453853-A1 (CA)
Inventor: VANSTONE SCOTT A
IPC: H04L9/32
Filed: 2002-07-16
Abstract: A method of establishing a trusted path of data and a method of verifying the integrity of data presented for signing to a user of the personalized device in a public-key cryptographic scheme. The method comprises establishing a trusted path between the user and secure module residing on the personalized device. The secure module holds the user's private key, displays information about the data message directly to the user, and generates the signature only when instructed to do so. The decision whether or not to sign the data message is determined by the user.
Patent CA-2456823-A1 (CA)
Title: Ca-mm-ni based hydrogen storage alloys
Inventor: LIANG GUOXIAN
IPC: H01M8/065
Filed: 2004-02-04
Abstract: New alloys of the AB5 type are disclosed which are of the formula: (Ca x M1-x)t(N1-y T y)5 where M is one or several metals selected from the group consisting of misch metal (Mm) and other rare earth metals T is one or several semi-metals such as Si, Ge and Ga; 0<x <=1; 0<y <=0.5 and 0.8 <= t <= 1.2.   Also disclosed is a process for preparing these new alloys and their use for hydrogen storage.
Patent CA-2457802-A1 (CA)
Inventor: SHAFFER MYRON W
IPC: C08G18/42
Filed: 2002-09-20
Abstract: Biuret group-containing polyisocyanates are produced having an isocyanate functionality of at least (4) are prepared by reacting polyisocyanates havin g a functionality of at least (2.8) with water as the biuretizing agent. Most preferably water is used as the sole biuretizing agent. The preparation is useful as a curing agent in crosslinkable coating compositions. The coating composition can be used as an automotive clearcoat over a conventional pigmented basecoat, or as a basecoat or monocoat or even as a primer or seal er when a suitable amount of pigment is incorporated therein.
Patent CA-2459273-A1 (CA)
Inventor: MULROY LOUISE
IPC: A61L28/00
Filed: 2002-08-30
Abstract: A drainage bag for receiving bodily waste, such as an ostomy bag, comprises an outer bag of material soluble in cold water,e.g. polyvinyl alcohol, and an inner bag of material insoluble in water at ambient temperature and body temperature but soluble in organic solvent,e.g. 2-oxepanone polymer (polycaprolactone). When the bag (and contents) are to be disposed of, appropriate organic solvent (e.g. benzyl alcohol) is applied to the inner bag.  The bag can then be placed in a WC bowl and is flushable after about 1-2 minutes.
Patent CA-2461386-A1 (CA)
Inventor: FRASER IVAN FRANCIS
IPC: B65B67/08
Filed: 2004-03-18
Abstract: A manual dispenser for stretch wrap material and having a dispenser body, a handle on the dispenser body' and, a roll carrier extending from the dispenser body for receiving a roll of stretch wrap material and being rotatable so as to permit controlled unwinding of the stretch wrap material from the roll. The dispenser may be attached at one end of the core for single handed operation, or two dispensers may be used, one at each end of the roll for double handed operation. Core adapters are provided to accommodate rolls having cores of different sizes
Patent CA-2462476-A1 (CA)
Title: Fuel composition containing molybdenum source and metal-containing detergent, and its use in two-stroke engines
Inventor: GROWCOTT PETER
IPC: C10N10/04
Filed: 2004-03-30
Abstract: A fuel composition, and a method and an apparatus for combusting it in a two-stroke engine, in which molybdenum introduced from the fuel will interact with alkaline earth metal originating from a detergent or other co-ingredient of the fuel in the combustion products to increase detergency without increasing the level of alkaline earth metal or compounds present in the fuel or combustion products thereof. In this manner, the engine operates more cleanly and efficiently without increasing the risk of harmful alkaline earth materials and compounds thereof blocking and poisoning catalysts, sensors and/or automotive on-board diagnostic devices, and it can lead to improved durability of exhaust after treatment systems.
Patent CA-2466373-A1 (CA)
Inventor: MOHAMUD FARAH
IPC: A47J47/00
Filed: 2004-05-10
Abstract: In the past many tools have been invented to perfect the art of producing cake layers. In our invention, a cutting blade extends horizontally between the legs of a U-shaped frame, whose height can be adjusted incrementally so as to produce a cake layer of desired thickness. Additionally, the U-shaped frame is mounted on castors that roll almost frictionlessly, allowing the cutting blade to slice the cake into perfect layers.
Patent CA-2466693-A1 (CA)
Inventor: CLARKE JOHN
IPC: B60R25/09
Filed: 2004-05-07
Abstract: The invention provides an immobilization apparatus for a vehicle having a wheel with a tire. The apparatus comprises first and second elongated members having inner ends and outer ends. The inner ends are connected together and the outer ends are angularly spaced apart. There is an L-shaped clasp at each of the outer ends for grasping the tire. The clasps are rotatable about the outer ends. A third elongated member has an inner portion and an outer portion and is angularly spaced-apart from the first and second members. The inner portion is tubular and the outer portion of the third elongated member is telescopically received therein. The outer portion has an L-shaped clasp, and the outer portion is rotatable with respect to the inner portion. A locking mechanism secures the outer portion at a fixed telescopic position with respect to the inner portion of the third elongated member.
Patent CA-2466855-A1 (CA)
Title: Modular trough convey0r belt and modules
Inventor: CORLEY ANDREW A
IPC: B65G17/08
Filed: 2004-05-11
Abstract: A modular conveyor belt constructed of a series of rows of belt modules with a hinge formed in each row and aligned in the direction of belt travel with hinges of adjacent rows. The hinge allows the belt to conform to a non-coplanar carryway support to form, for example, a trough. In some versions, the hinge is a living hinge formed by flexible or thinned-out regions of the belt between rigid regions. In other versions, the hinge is formed by interleaved hinge eyes between modules along each row interconnected by a hinge pin along an axis oriented in the direction of belt travel.
Patent CA-2467715-A1 (CA)
Inventor: SANTORA ART
IPC: G01N33/15
Filed: 2004-05-19
Abstract: Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing.  Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.
Patent CA-2470457-A1 (CA)
Inventor: DOTTE EMMANUEL
IPC: B65G1/137
Filed: 2003-01-08
Abstract: An extraction system is movable in front of the rack structure in order to remove articles from specific trays. The trays include freely moving conveyors, able to advance stored articles to a dispensing position. The extraction system includes a drive wheel engaging the conveyor by friction, in order to move an item from storage on to the presented extraction system surface.  Stored articles are held on the trays of a rack structure, and the extraction system is movable in front of the rack structure so that it can be aligned in front of one bay of a tray carrying a stack of articles. Articles (11) having the same reference number of stored adjacent to each other on the upper side (13a) of one of several freely moving continuous conveyor belts (13). The conveyor belts can be selectively motorised, causing articles to move forward to the point of removal. The driving of the conveyor belts is achieved by wheels (23) on the mobile extraction system engaging the respective conveyor belt by friction. This advances at least one stored article, and moves it to the collection surface (22a) of the extraction system.
Patent CA-2470478-A1 (CA)
Inventor: GATHJE JOHN C
IPC: C22B3/04
Filed: 2002-12-17
Abstract: A method for the treatment of sulfide ores containing silver by pressure oxidation (108). The method includes the addition of a sulfate-binding material (106) to reduce the formation of jarosite species during pressure oxidation (108). Silver can then be recovered from the solids portion of the discharge slurry (109). A jarosite reduction step, such as by a lime boil, that is typically required to recover silver after pressure oxidation (108) can be eliminated.
Patent CA-2470979-A1 (CA)
Inventor: KRAFT LARS
IPC: A61K6/876
Filed: 2002-12-19
Abstract: The present invention relates to a chemically bonded ceramic material based on calcium aluminate hydrate with additives of primarily calcium titanate, but also chemically similar compounds. The material is a biocompatible material for implants, particularly for orthopaedic and dental applications. The invention also pertains to products that at least in part have been made fro m the material. The material of the invention possesses the properties require d for an orthopaedic biocement. It cures through reaction with water and develops its strength within a short period of time, has good workability prior to curing, is shape stable, has a low heat generation during curing, a nd is friendly to adjacent tissues.
Patent CA-2476059-A1 (CA)
Title: A low-nitrogen content phenol-formaldehyde resin
Inventor: WINTEROWD JACK G
IPC: C08L97/02
Filed: 2004-07-26
Abstract: A low-nitrogen content, high molecular weight, phenol-formaldehyde resin. The low-nitrogen content, high molecular weight, phenol-formaldehyde resin has a nitrogen content of from about 0 to 3%, a viscosity of from about 20 to 2000 cps at 20°C, and a molar ratio of formaldehyde/phenol of from about 1.2 to 3Ø
Patent CA-2478385-A1 (CA)
Title: Flow control/shock absorbing seal
Inventor: TSAUR GARRY
IPC: B65D35/00
Filed: 2002-03-04
Abstract: The present invention is a flow control/shock absorbing seal (1) that will absorb the shocks transmitted to the liquids (2) in a container during transportation to prevent leakage and maintain the separation of the liquid (2) and the air chamber (3) in the container and controls the rate of flow of the liquid (2) from the container. The present invention allows the rate of flow of the liquid (2) from the container to be predetermined and controlled economically and accurately. The present invention may also allow the forced ejection of the liquid (2) from the container.
Patent CA-2478396-A1 (CA)
Inventor: KOSLOW EVAN E
IPC: B01D53/26
Filed: 2003-02-14
Abstract: A desiccant system and a method for producing the same wherein a container (20) is provided with a desiccant sheet (10) that is trapped within the container (20) and a water vapor impermeable cover (26) for the container (2 0) making a water impermeable seal thereto. The sheet (10) may have a first substrate (12), and optionally, a second substrate (14), and desiccant particles adhered to the first substrate (12) or trapped between the first substrate (12) and the second substrate (14). A binder material may fuse the desiccant particles to one another and the substrates (12 and 14). The sheet may be trapped within the bottle (20) due to its tendency to unfurl to a fla t condition, or it may be adhered to an inner surface of the bottle (20).</SDO AB>
Patent CA-2478780-A1 (CA)
Title: Aircraft equipped with thrust reversers
Inventor: ANDRE JOAN
IPC: B64D27/18
Filed: 2004-08-09
Abstract: The aircraft has engines (5-8) whose speed is controlled by throttles (11-14). The inner engines (5, 6) have thrust reversers (9, 10) passing from inactive folded position to an active deployed position, and vice versa. A detector (33) detects the deployment of the reversers and controls locking devices (36, 37) to lock the throttles (13, 14) related to outer engines (7, 8), when the reversers pass from folded to deployed positions.
Patent CA-2478820-A1 (CA)
Inventor: WILLMOTT COLIN B
IPC: H02P25/04
Filed: 2003-03-19
Abstract: L'invention concerne un moteur d'entraînement asymétrique ainsi qu'un appareil comprenant ce moteur et entraînant une barrière. Le moteur d'entraînement asymétrique entraîne la barrière avec différentes puissances selon la direction, le temps de déplacement, les besoins de sécurité ou la vitesse. La puissance d'entraînement est commandée par changement électrique de la valeur du condensateur d'un moteur à condensateur permanent.
Patent CA-2483983-A1 (CA)
Inventor: MUNKO GARY W
IPC: C08G18/72
Filed: 2004-10-06
Abstract: The present invention relates to an improved isocyanate reactive mixture containing at least one DMC-catalyzed polyol and about 0.25 to about 15 wt. %, based on the total weight of the isocyanate-reactive mixture, of at least one ethylene oxide (EO) containing water compatibilizer. The isocyanate reactive mixtures of the present invention may find use in the preparation of polyurethane foams, coatings, elastomers, sealants, adhesives and the like.
Patent CA-2485449-A1 (CA)
Inventor: ENGSTAD ROLF
IPC: A61K31/716
Filed: 2004-10-08
Abstract: The current invention describes a method for preventing and/or treating mucositis with a branched water soluble .beta.-1,3-glucan. Water soluble .beta.-glucan is used to prevent development of and/or promote healing of ulcers as exemplified by mouth and oropharynx ulcerations resulting from radio- and/or chemotherapy. The soluble .beta.-glucan can be applied directly to the potential affected mucosal areas as a solution, or mixture, or rinse, or gel, or mixed into any pharmaceutically acceptable carrier or vehicle. Other aspects of the invention are glucans for use in therapeutic compositions and uses of .beta.-glucan.
Patent CA-2487566-A1 (CA)
Title: Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases
Inventor: SAUVE ANTHONY A
IPC: C07H19/048
Filed: 2003-05-30
Abstract: The present invention provides compounds having the formula: (I); Also provided are pro-drug compounds of the formula: (II); The invention also provides pharmaceutical compositions containing the above compounds, methods of using the above compounds as pharmaceuticals, and processes for preparing the above compounds. Methods for inhibiting an ADP-ribosyl transferase, ADP-ribosyl cyclase, ADP-ribosyl hydrolase, or NAD-dependent deacetylase enzyme using the above compounds, and methods for treating a disease or condition associated with an ADP-ribosyl transferase, ADP- 'ribosyl cyclase, ADP-ribosyl hydrolase, or NAD-dependent deacetylase enzyme in a subject using the above compounds are also provided.