Patent SG-11201907033S-A (SG)
Title: In vivo drug delivery devices and methods for drug delivery
Inventor: LEE HEEJIN
IPC: A61K9/00
Filed: 2018-02-01
Abstract: /'.. ,- .-,, rs 1 I I I 1 r I 1 I i 07Mo° 64 60\ 0 0 oev: 52 54 50 62 54 _L.J. I I I 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) W I P0 I P C T o mono °nolo Ho Ho Ho Immo En oimIE (10) International Publication Number WO 2018/144738 Al (51) International Patent Classification: A61M 31/00 (2006.01) A61K 9/00 (2006.01) (21) International Application Number: PCT/US2018/016463 (22) International Filing Date: 01 February 2018 (01.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/453,333 01 February 2017 (01.02.2017) US 62/480,744 03 April 2017 (03.04.2017) US (71) Applicant: TARIS BIOMEDICAL LLC [US/US]; 113 Hartwell Avenue, Lexington, Massachusetts 02421 (US). (72) Inventors: LEE, Heejin; 1103 Albion Road, Bedford, Massachusetts 01730 (US). ABBATE, Emily; 6 Lone Star Drive, Nashua, New Hampshire 03062 (US). HOCKING, Sarah; 345 Washington Street, Winchester, Massachusetts 01890 (US). GIESING, Dennis; 4421 SW Gull Point Dri- ve, Lees Summit, Missouri 64082 (US). (74) Agent: FREDRICH, Stacy D. et al.; Eversheds Suther- land (US) LLP, 999 Peachtree Street, NE, Atlanta, Georgia 30309-3996 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) 1-1 GC N 1-1 00 O O 1-1 (54) Title: IN VIVO DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY FIG. 2 (57) : Drug delivery devices and methods of administering drugs to patients are provided. A device (50) includes a reservoir (60) containing a drug (58). The reservoir (60) is defined by a wall (64) having a water-permeable portion, such that the water-permeable portion permits water to enter the device (50) and contact the drug (58). A restraining plug (56) closes off an opening of the device (50) such that transient microchannels (62) form between an elastic portion (54) of the device (50) and the restraining plug (56), upon the generation of a sufficient pressure within the reservoir (60), to release the drug (58) from the device (50). Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also described.