Patent SG-11201804826T-A (SG)
Title: Method for producing n-retinoylcysteic acid alkyl ester
Inventor: ALEKSOV JULIAN
IPC: C07C403/22
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DEEM II 11111111111111111111111111111111 RID IIII (10) International Publication Number WO 2017/099662 Al WIPO I PCT (43) International Publication Date 15 June 2017 (15.06.2017) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KB, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: (51) International Patent Classification: C07C 403/22 (2006.01) CO7C 309/23 (2006.01) C07C 30 9 / 1 8 (2006.01) CO7C 313/04 (2006.01) (21) International Application Number: PCT/SE2016/051238 (22) International Filing Date: 9 December 2016 (09.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1551615-6 9 December 2015 (09.12.2015) SE (71) Applicant: ARDENIA INVESTMENTS, LTD. [GB/GB]; 45 Welbeck Street, London WIG8DZ (GB). (72) Inventors; and (71) Applicants : BABROU, Dzianis [SE/SE]; Stigbergsplan 3, 75242 Uppsala (SE). BUDNIKAVA, Maryna [SE/SE]; Stigbergsplan 3, 75242 Uppsala (SE). BJORKLUND, Mi- kael [SE/SE]; Tingshogsgatan 9, 753 34 Uppsala (SE). ALEKSOV, Julian [SE/SE]; Karins All& 6, 181 44 Lid- ingo (SE). (74) Agent: BERGENSTRAHLE & PARTNERS STOCK- HOLM AB; P.O. Box 17704, 118 93 Stockholm (SE). with international search report (Art 21(3)) W O 20 17 /09966 2 Al (54) Title: METHOD FOR PRODUCING N-RETINOYLCYSTEIC ACID ALKYL ESTER (57) : A method for producing derivatives of N-retinoylaminoalkane sulfonic acid, the method comprising providing retino - ic acid, chloroformate, aminoalkanesulfonic acid selected from the group consisting of cysteic acidand alkyl ester thereof, cysteines - ulfmic acid and alkyl ester thereof, homocysteic acid and alkyl ester thereof, homocysteinesulfinic acid and alkyl esters thereof, taur - ine and derivatives thereof, and an organic solvent,and a base, mixing said components under substantial absence of oxidizing com - poundsthereby forming a reaction mixture comprising a liquid phase, wherein the liquid phase is one phaseand the derivatives of N- retinoylaminoalkane sulfonic acid are foiined in said liquid phase.