Patent SG-11201810983P-A (SG)
Title: Novel heterocyclic derivatives useful as shp2 inhibitors
Inventor: MA CUNBO
IPC: A61P21/00
Filed: 2017-06-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111110111101110111111110101111100111111111111111100111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/211303 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CO7D 401/14 (2006.01) A61K 31/537 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 401/04 (2006.01) A61P 35/00 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, CO7D 471/10 (2006.01) A61P 9/00 (2006.01) HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, CO7D 491/107 (2006.01) A61P 19/00 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, CO7D 498/10 (2006.01) A61P 21/00 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, A61K 31/506 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (21) International Application Number: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, PCT/CN2017/087471 TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 07 June 2017 (07.06.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (25) Filing Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (26) Publication Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (30) Priority Data: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/CN2016/085122 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 07 June 2016 (07.06.2016) CN KM, ML, MR, NE, SN, TD, TG). (71) Applicant: JACOBIO PHARMACEUTICALS CO., Published: LTD. [CN/CN]; Unit 2, Building 5, BYBP, No.88 — with international search report (Art. 21(3)) Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). (72) Inventors: MA, Cunbo; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). GAO, Panliang; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Develop- ment Area, Daxing, Beijing 101111 (CN). CHU, Jie; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). WU, Xinping; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). WEN, Chunwei; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Dax- ing, Beijing 101111 (CN). KANG, Di; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). BAI, Jinlong; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). PEI, Xi- aoyan; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, Il (54) en en Il Title: NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS (57) : Provided are certain pyrazine derivatives (I) as SHP2 in- R4 hibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused Il e , ' Y 2 R3,„„.• .\ x heterocyclic derivatives useful as inhibitors of SHP2, methods for produc- .„./'-' ''',„,,,,. N Ir . \"' Il ei 1 ing such compounds and methods for treating SHP2-mediated disorder. a 1 (1) R5 C