baber/WOPTO huggingface dataset:
Patent NZ-595275-A (NZ)
Title: Preparation of octahydro-pyrrolo[3,4-b]pyrrole derivatives
Inventor: ZHENG GUO ZHU
IPC: A61K31/407
Filed: 2007-02-16
Abstract: Abstract - 595275 Disclosed is a process of preparing compounds of formula (IV), wherein R1 is an alkyl group and Cy1a is aryl or heteroaryl, comprising the step of treating a compound of formula (III) with alkylating conditions to provide a compound of formula (IV). Also disclosed is a process for preparing a compound of formula (IV), wherein R1 is an alkyl group, and Cy1 is aryl, comprising the steps of: a) providing ethyl (3aR,6aR)-hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate dibenzoyl-D-tartrate salt; b) treating ethyl (3aR,6aR)-hexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate dibenzoyl-D-tartrate salt with a base to yield a compound of formula (IIIa); c) heating the compound of formula (IIIa), wherein P is ethoxycarbonyl and a compound of formula (IIIb), with a carbonate base, a palladium source, and Xantphos in a solvent, to provide a compound of formula (IIIc); d) heating the compound of formula (IIIc) with a compound of formula (IIId), a carbonate base and a copper source in a high-boiling polar solvent (such as dimethylformamide (DMF), dimethylacetamide (DMA), pyridine, or 4-methylpyridine) to provide a compound of formula (IIIe); e) removing the ethoxycarbonyl group to provide a compound of formula (III), and alkylating the compound of formula (III) to provide a compound of formula (IV), wherein the compound of formula (IV) is a compound such as 2-{ 4'-[(3aR,6aR)-5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1'-biphenyl-4-yl} pyridazin-3(2H)one.
Patent NZ-595884-A (NZ)
Title: Rifamycin derivatives derived from microorganisms and their use as antibacterial agents
Inventor: VISCOMI GIUSEPPE CLAUDIO
IPC: A61K31/437
Filed: 2010-03-18
Abstract: Disclosed are compounds including rifamycin derivatives having antibacterial activities, wherein the compounds have the following general formula (I) wherein: R is hydrogen or acetyl R1 and R2 are independently selected from the group consisting of hydrogen, ( C1-4) alkyl, benzyloxy, mono- and di-(C1-3) alkylamino-(C1-4)alkyl, (C1-3)alkoxy, (C1-4) alkyl, hydroxy-methyl, hydroxy-(C2-4)-alkyl, and nitro or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups and R3 is hydroxyalkyl (C1-4). In addition, processes to obtain these compounds are described. The compounds have antibacterial activity.
Patent NZ-596702-A (NZ)
Title: Resettable drug delivery device
Inventor: JONES CHRISTOPHER
IPC: A61M5/315
Filed: 2010-05-28
Abstract: 596702 Disclosed is a resettable drug delivery device having a resettable dosing mechanism. The dosing mechanism comprises a dose button (66), a rotatable dial grip (52) operatively coupled to the dose button for setting a dose, a spindle (see 64, figure 3) for acting on a bung of a cartridge, and a driver operatively coupled to the dose button and the spindle. During an injection of a dose, the dose button moves in an axial direction to cause the spindle to administer said dose. A resetting mechanism is further provided. During resetting of the dosing mechanism using the resetting mechanism the spindle is retracted back into the dosing mechanism. The resetting mechanism is activated by pulling the dial grip in a proximal direction.
Patent NZ-599133-A (NZ)
Title: Hcv protease inhibitors
Inventor: LIU CHEN-FU
IPC: A61K31/4355
Filed: 2009-09-15
Abstract: Disclosed are macrocyclic compounds of the given formula formula wherein Y is a fused tricyclic unsaturated moiety, processes for their preparation, compositions comprising said compounds and uses thereof. Specific compound of formula (I) include: { 4-Cyclopropanesulfonylaminocarbonyl-2, 15-dioxo-18-[2-(4-trifluoromethyl-phenyl)-benzo[4,5]furo[3,2-d]pyrimidin-4-yloxy ]-3,16-diazatricyclo[14.3.0.04,6]nonadec-14-yl} -carbamic acid cyclopentyl ester Compounds of formula (I) are useful for treating hepatitis C virus infections.
Patent NZ-605438-A (NZ)
Title: Multiple input biologic classifier circuits for cells
Inventor: BENENSON YAAKOV
IPC: G06N3/00
Filed: 2011-07-22
Abstract: Discloses is a high-input detector module comprising (a) an inducible promoter sequence operably linked to a repressor sequence, a sequence encoding a microRNA target sequence and, (b) a repressible promoter sequence operably linked to an output sequence encoding an output product, wherein said repressor product is specific for the repressible promoter sequence, the module further comprises one or more regulatory units, comprising a constitutive or inducible promoter sequence operably linked to: (i) a sequence encoding a transcriptional activator product and (ii) a sequence encoding one or more microRNA target sequences, wherein the transcriptional activator product activates the inducible promoter sequence linked to the repressor sequence.
Patent NZ-612525-A (NZ)
Title: Bridged piperidine derivatives
Inventor: THOMAS ANDREW
IPC: C07D519/00
Filed: 2012-02-28
Abstract: Provided are bridged piperidine derivative compounds of general formula (I), where the variables are as defined in the specification. Examples of the compounds include [(rac)-3-exo-8-(2-Chloropyridin-4-yl)-8-aza-bicyclo [3.2.1 ] oct-3-yl]-[8-(3,4-difluorophenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amine and 2-{ 6-(4-Chloro-benzyl)-2-[(rac)-3-endo-8-(3-methyl-[1,2,4]thiadiazol-5-yl)-8-azabicyclo[3.2.1] oct-3-ylamino]-pyrimidin-4-yl} -propan-2-ol. The compounds are modulators of amyloid beta and may be useful in the treatment or prevention of Alzheimer’s disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome. Further provided are tablet and capsule formulations comprising the compounds.
Patent NZ-615694-A (NZ)
Title: Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
Inventor: TREMBLAY GILLES BERNARD
IPC: C12Q1/02
Filed: 2012-03-28
Abstract: Discloses antibodies and antigen binding fragments that bind to KAAG1 and associated methods and uses in treatment, detection and diagnosis of cancers comprising KAAG1 expressing cells, comprising heavy chain CDR sequences: GYTFTDDYMS; DINPYNGDTN; DPGAMDY; and light chain CDR sequences: RSSQSLLHSNGNTYLE; TVSNRFS; FQGSHVPLT.
Patent NZ-625624-A (NZ)
Title: Humanized antibodies that recognize alpha-synuclein
Inventor: SALDANHA JOSE
IPC: C07K16/00
Filed: 2012-10-26
Abstract: Disclosed are humanised forms of the mouse 9E4 antibody which comprise the CDRs as defined in the specification and the use of said antibodies for treating synucleinopathy and reducing Lewy body formation.
Patent NZ-702952-A (NZ)
Title: Assembly and method for managing components of a telecommunication system
Inventor: PIKE STEPHEN
IPC: H05K7/12
Filed: 2012-06-15
Abstract: An assembly (10) for managing components of a telecommunication system comprises a supporting frame (20) having at least one shaped opening (21) and at least one supporting member (40) for said component. The supporting member (40) has an integral portion adapted to be inserted into the shaped opening (21). A locking element (50) is associated with the supporting member (40). The locking element (50) is movable on said supporting member between a first operative position in which said integral portion of the supporting member (40) can be inserted into said shaped opening (21) and extracted therefrom, and a second operative position in which extraction of said integral portion of the supporting member (40) from said shaped opening (21) is prevented, whereby fixedly associating said supporting member (40) with said supporting frame (20).
Patent NZ-704044-A (NZ)
Title: Dispensing of food and beverage products
Inventor: THORMAN WILLIAM
IPC: G07F9/10
Filed: 2013-08-06
Abstract: A cooler cabinet comprises: a storage compartment (130) for food or beverage products (144); a dispensing mechanism (143) for dispensing the food or beverage products (144) from the storage compartment without opening the storage compartment to ambient air; a water-retaining material (120) outside the storage compartment but in contact with it; an air channel (111) in contact with the water-retaining material; and means (114) for moving air through the air channel such that the air increases the rate of evaporation of water from the water-retaining material. It thereby withdraws heat from the water-retaining material and causes cooling of the interior of the cabinet, including the food or beverage products..
Patent NZ-714821-A (NZ)
Title: Processes of making and crystalline forms of a mdm2 inhibitor
Inventor: BIO MATTHEW
IPC: C07D498/04
Filed: 2014-06-09
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3- chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3- methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Patent NZ-716195-A (NZ)
Title: Methods of treating pruritic conditions mediated through histamine h-4 receptors
Inventor: ABERG A K GUNNAR
IPC: A61P17/04
Filed: 2014-07-31
Abstract: The methods disclosed herein relate to the treatment of histamine H-4 - related dermal disorders, by administering a histamine H-4 receptor inverse agonist that selectively accumulates at the biophases for the disorders, specifically RS-norketotifen or a pharmaceutically acceptable salt thereof. Potentiated antipruritic activity by simultaneous inhibition of histamine H-1 receptors and histamine H-4 receptors are described.
Patent NZ-722624-A (NZ)
Title: Fused pyrimidines as inhibitors of p97 complex
Inventor: ZHOU HAN-JIE
IPC: C07D491/052
Filed: 2015-01-19
Abstract: The present invention is directed to certain fused pyrimidines of formula I having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion partner; having an amino benzyl or substituted amino benzyl group at the 4 position of the pyrimidine ring; and a 5:6 heterobicyclo ring with at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for treatment of cancer by inhibition of the p97 complex.
Patent NZ-746700-A (NZ)
Title: Bcma binding molecules and methods of use thereof
Inventor: WILTZIUS JED
IPC: A61K35/12
Filed: 2017-03-31
Abstract: The invention provides antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs), and engineered T cell receptors, polynucleotides encoding the same, and in vitro cells comprising the same. The polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered CAR T cell therapy for the treatment of a patient suffering from a cancer. In one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.
Patent NZ-758068-A (NZ)
Title: Fencing systems, components thereof and methods for using the same
Inventor: SCHILLEMAN RYAN
IPC: F16B45/02
Filed: 2018-03-29
Abstract: Fencing systems and components thereof are disclosed herein. In one form, a device for coupling a fence wire to a post is provided. In another form, a method is provided for coupling a fence wire to a post through use of the disclosed device. The invention aims to provide a secure form of fence closure.
Patent NZ-778715-A (NZ)
Title: Blower
Inventor: MOIR MICHAEL BRUCE
IPC: F04D19/02
Filed: 2012-08-02
Abstract: A Positive Air Pressure device comprises a fan and a housing with an end cap, where the housing has a number of parallel inlet passages and the end cap an outlet tube for the fan, and where the tube axis is parallel to that of inlet passages. The multiple parallel inlet passages make the inlet air flow laminar and so quieter.
Patent PT-103837-A (PT)
Title: Caça cartuchos
Inventor: MOREIRA AUGUSTO RODRIGUES
IPC: E01H1/12
Filed: 2007-09-28
Abstract: A PRESENTE PATENTE REFERE-SE A UM DISPOSITIVO COMBINADO DE ARTICULAÇÃO E ABERTURA/FECHO PARA UM APANHA CARTUCHOS DE TIRO, O QUAL COMPREENDE UM CONJUNTO DE ARTICULAÇÃO E UM CONJUNTO E ONDE ESTÁ DISPOSTO NA EXTREMIDADE SUPERIOR UM PUNHO DE BORRACHA PERFEITAMENTE ADAPTÁVEL Á MÃO DO HOMEM E NA EXTREMIDADE OPOSTA UM ÍMAN QUE FAZ COM QUE OS CARTUCHOS VÃO TER Á MÃO DO HOMEM SEM QUE ESTE SE BAIXE. O PRESENTE PEDIDO DE PATENTE É APLICÁVEL NA APANHA DE CARTUCHOS DE TIRO.
Patent PT-104561-A (PT)
Title: Sistema experimental de ensino de diagnóstico e detecção de avarias em máquinas eléctricas
Inventor: ALVES MARTINS JOAO FRANCISCO
IPC: G05B23/02
Filed: 2009-05-11
Abstract: A PRESENTE INVENÇÃO TRATA DE SISTEMAS EXPERIMENTAIS PARA O ENSINO DO DIAGNÓSTICO E DETECÇÃO DE AVARIAS EM MÁQUINAS ELÉCTRICAS, BASEADO NA GERAÇÃO DE TENSÕES E/OU CORRENTES ADEQUADAS QUE PERMITEM COLOCAR UMA MÁQUINA SEM AVARIA EM MODO DE FUNCIONAMENTO AVARIADO. A INVENÇÃO BASEIA-SE EM CONVERSORES ELECTRÓNICOS DE POTÊNCIA COMUTADOS DO TIPO AC/DC/AC OU DC/AC OU MATRICIAL OU CONVERSORES ELECTRÓNICOS LINEARES E PODE SER UTILIZADA COM MÁQUINAS DE INDUÇÃO MONOFÁSICAS OU POLIFÁSICAS, OU EM MÁQUINAS SÍNCRONAS, OU EM TRANSFORMADORES, OU EM MÁQUINAS DE RELUTÂNCIA COMUTADA. ESTA INVENÇÃO CARACTERIZA-SE POR GERAR UM CONJUNTO ADEQUADO DE TENSÕES E/OU CORRENTES QUE ALIMENTAM A MÁQUINA ELÉCTRICA PARA QUE UMA MÁQUINA NÃO AVARIADA FUNCIONE EM MODO DE AVARIADA, SENDO QUE TODA A INFORMAÇÃO ESTÁ DISPONÍVEL NUM ECRÃ DE VISUALIZAÇÃO (DISPLAY).
Patent RU-94008089-A (RU)
Inventor: KUZNETSOV V M
IPC: B60S5/00
Filed: 1994-03-05
Abstract: FIELD: railway transport servicing of railway vehicles. SUBSTANCE: device has lift and mechanism to unwedge segments holding shackle combined by hydraulic system and installed on truck to be rolled under car on which removed draft gear is placed after demounting. Grip of segments has two opposite moving L-shaped jaws. Jaws are hinge-mounted through their horizontal arms on housing common with unwedging cylinder. Movable clamp straddles opposite bevelled edges of horizontal arms. Spring-loaded platform with friction lining is placed in clearance between clamp and housing. Upper ends of vertical arms have oblique-angled cutouts whose size is sufficient for complete enclosing of end faces of minimum type-size segments. Tie-up spring and equalizing yoke with ports not smaller than working stroke and section of jaws are installed at arm bending places. EFFECT: enlarged operating capabilities; possibility to use device for removing draft gears of different type-sizes. 3 cl, 1 dwg
Patent RU-94032016-A (RU)
Inventor: ORLOV A S
IPC: A23C9/127
Filed: 1994-09-08
Abstract: FIELD: dairy industry. SUBSTANCE: method involves milk purification, normalization, homogenization, sterilization, cooling down to best fermentation temperature, application of kefir starter and bifidobacteria, fermentation, cooling and bottling. Milk is deaerated after sterilization. Prior to application, biomass of bifidobacteria is washed with the use of a filtering plant for 2-4 h with continuous replacement of 0.8-1.2 volume of the filtered medium with 0.8-% NaCl solution 0.02M phosphate buffer pH 6.8-7.2 until the filtrate transparency exceeds 80% of that of the initial medium. EFFECT: higher nutritive and dietetic value of product.
Patent RU-94038515-A (RU)
Inventor: PITER SHLJUTER
IPC: B60T13/563
Filed: 1993-01-22
Abstract: FIELD: road vehicles; brake systems. SUBSTANCE: front portion of brake system booster housing 20 has two hollow inner members with thread 26. Each member engages with hole 68 made in flange 70 of master cylinder 14 and serves as support for head 52 of bolt 50. Each bolt 50 passes through corresponding inner member with thread 26 and booster 12 and has portion with thread 58 which projects backwards from booster when is turned into bushing with thread 18 in automobile partition 16. Flange 70 of master cylinder 14 is clamped between inner members with thread 26 and outer members with thread 60 which are hollow and have inner diameters exceeding those of head 52 of corresponding bolt 50. Each outer member with thread 60 has bushing extension 62 engaging with corresponding hole 68 of flange 70. Outer member is connected by thread with inner member with thread 26 fitted in indicated hole. EFFECT: enhanced reliability of operation. 1 dwg
Patent RU-94045434-A (RU)
Inventor: SHEVTSOV V I
IPC: A61B17/66
Filed: 1994-12-27
Abstract: FIELD: medical equipment, can be used for fixation and dosed translocation of vertebral and their fragments at treatment of patients with injuries and diseases of the vertebral column. SUBSTANCE: the apparatus has supports made in the form of a pair of rigidly joined plates with holes and slots, that are installed in the same plane, fixatives of vertebral connected to each plate of the support and furnished with a bearing platform on the working end with holes, in which wood screws with a ground head are installed; the supports are interconnected by threaded guides. EFFECT: uniform transmission of compression and distraction forces simultaneously to the anterior and posterior areas of the vertebral column.
Patent RU-95101816-A (RU)
Inventor: KUZNETSOV E G
IPC: B60C13/00
Filed: 1995-02-07
Abstract: FIELD: tyre industry; tyres for cross-country vehicles, wheeled tractors, agricultural machines, chassis and other vehicles. SUBSTANCE: tyre has tread, beads and sides. Novelty in design of tyre is that its sidewall is made in form of corrugations whose peaks and valleys easily move towards or away from each other if tyre pressure in running vehicle is below rated value, and thanks to it support portion of tread, increasing in length, occupies flat position. EFFECT: increased area of tyre contact with ground and adhesion and reduced specific pressure on ground and tyre members. 2 cl, 2 dwg
Patent RU-95102569-A (RU)
Inventor: SOKOLOV A JU
IPC: B01D3/14
Filed: 1995-02-14
Abstract: FIELD: alcohol industry. SUBSTANCE: method consists in epuration of water-alcohol mixture in epuration column followed by strengthening in alcohol column and further rectification to produce commercial alcohol. Epuration column is supplied with hot water and air in amount 0.1-50 cu.dm per 1 cu.dm of alcohol, and epuration is carried out in presence of basic reagent taken in amount 0.01-3.0 g per 1 cu.dm of alcohol. As basic reagent, potassium, sodium or ammonium hydroxide, carbonate or bicarbonate are used entering them into any part of epuration column, for example, together with column feed or with water fed for hydroselection process. Air is also fed into any part of epuration column. EFFECT: improved process flowsheet.
Patent RU-95104043-A (RU)
Inventor: NALAPKO V I
IPC: A61K6/838
Filed: 1995-03-21
Abstract: FIELD: medicine. SUBSTANCE: material has, wt.-%: powders or granules of hydroxylapatite with tricalcium phosphate at ratio = (3-4):1 75-80; lyncomycin 16-17; trypsin 1-0.5; and anticoagulants of direct action 7-7.5. Material has paste-like consistence. EFFECT: enhanced effectiveness and quality of material. 1 cl, 2 dwg
Patent RU-95105796-A (RU)
Inventor: DZHEROM F DZHAMINET
IPC: E05F15/60
Filed: 1995-04-07
Abstract: FIELD: construction of lifts. SUBSTANCE: door or doors of lift are operated by opening and closing cycles effected by one or more units of linear asynchronous motor in which element of stator winding is attached to lift cab structure, and rotor winding element is attached to lift door. If cab has two doors moving in opposite direction, then it is preferably to provide two separate drives from motor, that is one drive for each door. In one version, motor elements are located so that they create normal force which is horizontal, and in other version created normal force is vertical. Mounting bracket of motor stator winding is used to attach stator winding element to upper member of cab structure. EFFECT: high efficiency.
Patent RU-95105827-A (RU)
Inventor: STEPANOV A S
IPC: F16K1/00
Filed: 1995-04-14
Abstract: FIELD: valving. SUBSTANCE: stop-drain valve has housing 1 and outlet passageway 2 and inlet passageway 3, interconnected through step passageway 4 edge 5 of which is brought into a contact with stop rod 6. Drain passageway 3 has cross-like branches that are ended with a conical threaded openings. EFFECT: enhanced reliability. 2 cl, 2 dwg
Patent RU-95107903-A (RU)
Inventor: LYKOV M V
IPC: F26B9/06
Filed: 1995-05-16
Abstract: FIELD: devices for drying dispersed materials; chemical, construction, food-stuffing and fuel industries and other industries. SUBSTANCE: gaseous heat-transfer agent is introduced in drying drum by means of gas duct of any construction; this process may be effected due to thermal decomposition and melting of materials being dried when they are mixed with high-temperature gaseous heat-transfer agent in furnace or in supply gas duct. Material and thermal calculations demonstrate that in production of diammonium phosphate, for example (scheme with ammonizer-granulator and drying drum) with waste dust-laden gases returned to drying drum, consumption of fuel, electric power and water are reduced, respectively, by 2017 reference fuel t/year, 2,0•10kWh/year and 7500 cu.m/year. Discharge of gas into atmosphere is reduced by 822•10cu.m/year. Capacity of drying drum is 19.6 t/h by finished product. Device may be used for drying any products. EFFECT: reduced consumption of fuel, electric power; reduction of gas effluents.
Patent RU-95108367-A (RU)
Inventor: VERZHBOVSKIJ G B
IPC: E04B1/32
Filed: 1995-05-22
Abstract: FIELD: construction engineering. SUBSTANCE: butt joint can be used in spacious coverings of various-purpose buildings. Separate panels of structures are connected to each other by means of central hollow core and attached to it are short lengths of tubes. Inserted between these tubes are bent members of specific configuration which are fastened to panel facing by means of dowels. Bent members are connected with core by means of rigid rods. EFFECT: reduced labour intensity in joining elevated panels. 3 dwg
Patent TW-200406787-A (TW)
Title: Expanded operating frequency synchronous semiconductor memory device having wave pipeline structure and wave pipeline control method thereof
Inventor: CHUNG DAE-HYUN
IPC: G11C11/407
Filed: 2002-10-30
Abstract: A synchronous semiconductor memory device that operates synchronized with an operation clock and methods of operating a semiconductor memory device are provided. The synchronous semiconductor memory device has a latency N, where N is an integer and includes a memory cell array, a stack unit having N storage units and a frequency detector configured to determine a relationship of a frequency of the operation clock with reference to a predetermined frequency so as to provide an output signal based on the relationship of the frequency of the operation clock to the predetermined frequency. A control circuit is configured to control the stack unit in response to the output signal of the frequency detector. The control circuit latches data read from the memory cell array and controls the stack unit so that the latched data is stored from a clock cycle when a read command is sent until an N-th clock cycle after the read command is sent if the frequency of the operation clock is greater than the predetermined frequency and delays the latched data for one clock cycle and controls the stack unit so that the delayed data is stored from one clock cycle after the read command is sent until an N+1 clock cycle after the read command is sent.