Patent SG-11201903797S-A (SG)
Title: An array of needle manipulators for biological cell injection
Inventor: BANERJEE ARUNAVA STEVEN
IPC: C12N15/89
Filed: 2017-10-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111010111 0111110101111111111111111111111010111111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/080324 Al 03 May 2018 (03.05.2018) W I PO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 15/89 (2006.01) C12M 3/00 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/NZ2017/050140 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 31 October 2017 (31.10.2017) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (30) Priority Data: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 2016904437 31 October 2016 (31.10.2016) AU (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: MEKONOS LIMITED [NZ/NZ]; 101 Pack- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, enham St, W., 1010 Auckland (NZ). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventor: BANERJEE, Arunava Steven; Skydeck, 2150 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Shattuck Avenue, Berkeley, 94704 (US). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (74) Agent: AJ PARK; State Insurance Tower, 1 Willis Street, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PO Box 949, Wellington 6140 (NZ). KM, ML, MR, NE, SN, TD, TG). = (54) Title: AN ARRAY OF NEEDLE MANIPULATORS FOR BIOLOGICAL CELL INJECTION = gb , _ 643 = - = 8.h • gb2 8113 = _ - _ — , = = = = \ \ _ = 6 c Il 71' ei M 0 (57) : A device is provided, comprising a cell GC to hold a cell. The device can further comprise a manipulator ---- communication with a respective micro-chamber, wherein GC needle is mounted to the stage, and the actuator is operable to apply 1-1 © a cell in the respective micro-chamber. ei r ' .:..: 4 '''V')` ::.:.':. . ... 58 Figure trap comprising array each , . 8a1 Q.a 1 a plurality comprising a plurality of manipulators, each manipulator in spatial manipulator comprises force to 5. , 4 , e . e A 6a 883 of micro-chambers, each micro-chamber configured a needle, a stage, and an actuator, wherein the the stage in a direction to move the needle to penetrate C [Continued on next page] WO 2018/080324 Al MIDEDIMOM0101011EFIENIRM01111011010HEMOVOIS Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of