Patent SG-11201901020R-A (SG)
Title: Anti-siglec-7 antibodies for the treatment of cancer
Inventor: BEBBINGTON CHRISTOPHER
IPC: C07K16/30
Filed: 2017-08-04
Abstract: 7000 3000 .5000 4000 3000 2000 1000 30 min Eq.; min 240 min 0 min N nation S7 internalization No inhibition 0.001 0.01 G. 1 10 Concentration S7 Ab i pgiihn s ms IgG1 573 (Kc1=422pM) 351 (Kel=41pM) iso.APC Concentration response curves for 24 hour time point 0 . . . ..... . 10. 10. 10. 10• 10'• 10• 10. 10. 10\" 10' 10. 10. 10 4 ug/m1 6000• a ono Z 4000 2000 1000 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIPO I PCT (51) International Patent Classification: C07K 16/30 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61P 35/00 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2017/045641 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/371,680 05 August 2016 (05.08.2016) US (71) Applicant: ALLAKOS, INC. [US/US]; 75 Shoreway Rd, Suite A, San Carlos, California 94070 (US). (72) Inventors: BEBBINGTON, Christopher; c/o 75 Shore- way Rd., Suite A, San Carlos, California 94070 (US). KO- RVER, Wouter; c/o 75 Shoreway Rd., Suite A, San Car- los, California 94070 (US). TOMASEVIC, Nenad; c/o 75 Shoreway Rd., Suite A, San Carlos, California 94070 (US). EL BADER, Suzy; c/o 75 Shoreway Rd., Suite A, San Car- los, California 94070 (US). LUEHRSEN, Kenneth; c/o 75 Shoreway Rd., Suite A, San Carlos, California 94070 (US). (74) Agent: LOCKYER, Jean M. et al.; KILPATRICK TOWNSEND & STOCKTON LLP, Mailstop: IP Docket- ing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, Geor- gia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: ANTI-SIGLEC-7 ANTIBODIES FOR THE TREATMENT OF CANCER Figure 10 01E1°1°1a °nolo omoiolomi oviiiiniflom (10) International Publication Number WO 2018/027203 Al 1-1 (57) : The invention provides methods and compositions for the treatment of cancer using anti-Siglec-7 antibodies. C [Continued on next page] WO 2018/027203 Al MIDEDIMOMMIDIREIDIMIONEEMIERVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))