baber/WOPTO huggingface dataset:
Patent IL-64301-A0 (IL)
Title: Diamond and cubic boron nitride abrasive compacts using size selective particle layers
IPC: C04B35/58
Filed: 1981-11-18
Abstract: Disclosed is an improved process for preparing a composite compact wherein a mass of abrasive crystals, a mass of metal carbide, and a bonding medium are subjected to a high-temperature/high pressure process for providing a composite compact. The sintered carbide mass supports the mass of abrasive crystals and bonding or catalyst metal, and the abrasive crystal grains are directly bonded to adjacent crystal grains in the mass thereof. Such improved process comprises disposing the mass of abrasive crystals in layers wherein the coarsest layer is closest to the carbide mass and is composed of crystals having a largest dimension of between about 75 and 500 microns and the finest layer is disposed farthest away in the carbide mass and is composed of crystals having a largest dimension of less than 10 microns. The abrasive crystals are selected from the group consisting of diamond and cubic boron nitride and preferably are diamond; the metal carbide preferably is tungsten carbide; and the bonding metal preferably is cobalt. The resulting improved composite compact also is disclosed.
Patent IL-75364-A0 (IL)
Title: 3-nitro-dihydropyridines,their preparation and pharmaceutical compositions containing them
IPC: A61K31/44
Filed: 1985-05-31
Abstract: Novel 3-nitro-dihydropyridine derivatives of the formula   <IMAGE> in which R1 and R2 each independently is hydrogen, C1-C4-alkyl, C1-C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, C1-C4-halogenoalkyl, C1-C4-halogenoalkylmercapto,   <IMAGE>  Z is oxygen or sulphur, R4 and R5 each independently is hydrogen, C1-C4-alkyl, C1-C6-alkoxy, halogen, C1-C4-halogenoalkyl, C1-C4-halogenoalkoxy or nitro, or R1 and R2, together with 2 C atoms of the phenyl ring form the ring   <IMAGE>  X is oxygen or sulphur, A is a hydrocarbon radical with up to 12 C atoms which optionally contains one or two identical or different chain members from the group comprising O, S and CO and/or which is optionally substituted by hydroxyl or aliphatic acyloxy with up to 4 C atoms, R3 is -O-COR6, -S-CO-R6, SH, OH , NH2,   <IMAGE>   NH-COR6, COOR6, NR7R8 or CONR7R8, R6 is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical, and R7 and R8 each independently is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical, or a physiologically acceptable salts thereof, which are active in circulation and exhibit positive inotropic activity.
Patent IL-75536-A0 (IL)
Title: Pseudomonic acid salt,its preparation and pharmaceutical and veterinary compositions comprising it
IPC: C07D/
Filed: 1985-06-17
Abstract: 57 Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate.Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described.
Patent IL-80441-A0 (IL)
Title: Hybrid microorganisms,their preparation and pesticidal compositions containing them
IPC: A01N63/23
Filed: 1986-10-28
Abstract: The invention provides novel microorganisms comprising the gene coding for B.t. kurstaki delta-endotoxin and the gene coding to B.t. tenebrionis delta-endotoxin, their preparation, pesticidal compositions comprising such microorganisms and their use.
Patent IL-87795-A0 (IL)
Title: Benzimidazoline-2-oxo-1-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/55
Filed: 1988-09-19
Abstract: New pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid derivatives which are 5-HT receptor antagonists useful as antiemetic agents and as gastric prokinetic agents of the following formula: <CHEM> wherein R represents a hydrogen atom, C1-6 alkyl, C1-6 alkenyl or C1-6 alkynil; R1 and R2 may be at the same time or not a hydrogen atom, halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 acyl, carboxyl, C1-6 alkoxycarbonyl, hydroxy, nitro, amino optionally C1-4 alkyl N-mono or di-substituted, C1-6 acylamino, C1-6 alkoxycarbonylamino, carbamoyl optionally C1-4 alkyl N-mono or di-substituted, cyano, C1-6alkylsulphinyl, C1-6 alkylsulphonyl, amino sulphonyl optionally C1-4 alkyl N-mono or di-substituted, C1-4 alkyl N-mono or di-substituted aminosulphonylamino, aminosulphonylamino; Y is oxygen or is N - R3 in which R3 is a hydrogen, a C1-6 alkyl or optionally substituted by one or more C1-6 alkoxy benzyl; A is a group selected from: <CHEM> wherein p is 0, 1; r is 0, 1, 2, 3; R4 is hydrogen atom or a C1-4 alkyl; R5 is a hydrogen atom, C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl,substituted phenyl C1-4 alkyl or R5 is a group of formula <CHEM> wherein R6 is hydrogen atom, C1-4 alkyl or an amino group and R7 is hydrogen atom or C1-6 alkyl, tautomers thereof and acid addition salts of the aforesaid compounds. The processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also described.
Patent IL-88209-A0 (IL)
Title: Quinoline derivatives and pharmaceutical compositions containing the same
IPC: A61P37/08
Filed: 1988-10-28
Abstract: This invention relates to quinoline derivatives (I), their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same. They are especially valuable as lipoxygenase inhibitors and/or leukotriene antagonists, typically antagonists of leukotriene D4, possessing anti-inflammatory and anti-allergic properties. <CHEM>  a is 0-2;  b is 0-1;  c is 0-4;  d is 0-5;  e is 0-4;  f is 0-5;  n is 0-2; R is independently hydrogen, alkyl, hydroxy, alkoxy, carboxy, carbalkoxy, halo, nitro, haloalkyl, cyano or acyl; R min  is independently hydrogen, alkyl, hydroxy, alkoxy, halo or haloalkyl;  R1 is independently hydrogen, alkyl or aralkyl;  R2 is -(CH2)x - X, where x is 0-3; X is hydrogen, alkyl, alkenyl, cycloalkyl, aryl aralkyl, hydroxy, alkoxy, aralkoxy, amino, mono-and di-alkylamino, aralkylamino, acylamino, carbamyl, carboxy, carbalkoxy, tetrazolyl, or acylsulfonamido; vicinal R2 groups together may be (CH2)y - where y is 1-4, thus forming a 3-6 membered ring; geminal R1 and R2 groups may together form a spiro substituent, -(CH2)z -, where z is 2 to 5; geminal R1 or R1 and R2 groups may together form an alkylidenyl substituent, =CHR1;   Z is -COOR1, CN, - @NHSO2R3, -@N(R1)2, -OR1, tetrazolyl or substituted tetrazolyl where the substituent may be alkyl, carboxyalkyl or carbalkoxyalkyl; and R3 is hydrogen, alkyl, haloalkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof.
Patent IL-99876-A0 (IL)
Title: Process for producing 6-(3-dimethylamino-propionyl)forskolin
IPC: C07D311/92
Filed: 1991-10-28
Abstract: Disclosed in a process for producing 6-(3-dimethylaminopropionyl)forskolin, comprising the sequential steps of:   (1) acetylating hydroxy groups in the 1-position and 7-position of a compound represented by the formula (III): <CHEM> to prepare 1-acetyl-6-(3-dimethylaminopropionyl)forskolin represented by the formula (II): <CHEM>  (wherein Ac represents acetyl group), and (2) selectively removing the acetyl group in the 1-position of the compound represented by the formula (II) in the presence of an amine represented by the formula (IV): <CHEM> (wherein R1 represents hydrogen atom or lower alkyl group having 1-6 carbon atoms, and R2 represents lower alkyl group having 1-6 carbon atoms, alkoxyalkyl group, aminoalkyl group or benzyl group) in a solvent to prepare 6-(3-dimethylaminopropionyl)forskolin represented by the formula (I): <CHEM>  (wherein Ac represents the same as defined in the formula (II)).   The compound (I) is promising as a therapeutic agent for cardiac failure.
Patent FI-20000522-A0 (FI)
Inventor: NISSILAE SEPPO
IPC: A61B5/22
Filed: 2000-03-07
Abstract: A heart rate measuring arrangement comprising measuring means (500A to 500B) for measuring a person's heart rate during exercise and a calculating unit (532) for calculating an assessment of the person's energy consumption during exercise using at least two calculating parameters, one of which is a heart rate parameter included in the person's measured heart rate information, the heart rate measuring arrangement further comprising presenting means (530) for presenting the formed assessment of the person's energy consumption. The calculating unit is arranged to use an energy consumption reference value as a calculating parameter, which reference value is obtained by using one or more performance parameters representing the person's physical performance.
Patent FI-20060680-A0 (FI)
Inventor: LEE YI-MING
IPC: G02B/
Filed: 2006-07-12
Abstract: A lens module includes a driving apparatus, a rotary device, and a lens assembly. The rotary device includes a contact portion having a continuous ramp and is rotated by the driving apparatus. The lens assembly includes a guide portion which contacts the contact portion and a lens moving along with the guide portion. A rotation of the rotary device is driven by the driving apparatus and a displacement of the lens assembly is promoted by the rotation of the rotary device via the guide portion so that focus is achieved.
Patent IL-100635-A0 (IL)
Title: Scanning apparatus
IPC: G03G15/05
Filed: 1992-01-12
Abstract: Scanning apparatus for scanning a medium and comprising medium support means for supporting a medium in a generally curved orientation by contacting substantially less than the entire surface area of the medium, scanning means for scanning said medium, means for curving a medium having a generally planar orientation into said curved orientation, means for restoring the medium from the curved orientation into a planar orientation and means for automatically loading the medium onto the medium support means and unloading the medium therefrom. <IMAGE>   <IMAGE>
Patent IL-103310-A0 (IL)
Title: Non-sticky,fat-containing confection
IPC: A23G3/34
Filed: 1992-10-01
Abstract: A non-sticky, fat-containing confection which has a smooth texture and which is quick setting, comprising sugar, fat and gellan gum.
Patent IL-103987-A0 (IL)
Title: Synthetic isohirudins with improved stability
IPC: C07K14/00
Filed: 1992-12-04
Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.
Patent IL-107567-A0 (IL)
Title: Delivery device having encapsulated excipients
IPC: A61K9/48
Filed: 1993-11-11
Abstract: PCT No. PCT/US93/09582 Sec. 371 Date May 11, 1995 Sec. 102(e) Date May 11, 1995 PCT Filed Oct. 13, 1993 PCT Pub. No. WO94/12152 PCT Pub. Date Jun. 9, 1994An asymmetric membrane, osmotic, delivery device having coated macroparticulate solubility modifiers. The device comprises a beneficial agent, an osmagent, a coated macroparticulate solubility modifier and an asymmetric membrane that surrounds the device components. The device is useful for dispensing a beneficial agent to an aqueous environment of use. The coated macroparticles modify the solubility of the beneficial agent so that it's release can be controlled. The larger size of the solubility modifier macroparticles provides, for example, a longer release duration than would have been possible with a smaller size.
Patent IL-118330-A0 (IL)
Title: Dipeptides which promote release of growth hormone
IPC: C07D207/14
Filed: 1996-05-20
Abstract: PCT No. PCT/IB95/00410 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed May 29, 1995 PCT Pub. No. WO96/38471 PCT Pub. Date Dec. 5, 1996Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.
Patent IL-120056-A0 (IL)
Title: Naphthalene derivatives
IPC: C07C69/738
Filed: 1997-01-23
Abstract: Naphthalene derivative of the formula [I]: <CHEM> wherein R<1> and R<2> are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R<3> is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: -OR<4> and -OR<5> are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.
Patent IL-122803-A0 (IL)
Title: Method fo detecting lung disease
IPC: C07H19/04
Filed: 1996-07-24
Abstract: A method of facilitating the obtaining of a mucus sample from at least one lung of a subject comprises administering to at least one lung of the subject, in an amount effective to hydrate lung mucous secretions and/or stimulate cilia beat frequency therein, uridine 5'-triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof, and, optionally, concurrently administering to said at least one lung a physiologically acceptable salt in an amount effective to hydrate lung mucus secretions therein. A sputum or mucus sample is then collected from said at least one lung, which sample can then be analyzed for lung disease. Pharmaceutical compositions useful for carrying out the method comprise UTP or a salt thereof, alone or in combination with a physiologically acceptable salt, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid/liquid suspension composition or a dry powder composition.
Patent IL-130016-A0 (IL)
Title: Packaging of smoking articles
IPC: B65D75/58
Filed: 1997-11-19
Abstract: A pack for cigarettes and like smoking articles has a frame (101) outside the charge of cigarettes but inside a flexible wrap, which is preferably a sealed enclosure of a barrier material such as a metal/plastic laminate, or metallized foil. The inner frame which is not rigid since its side (104) and end (108) flaps are free except where attached to a major panel (102) acts to collate and protect the charge of cigarettes and to allow heat-sealing or other sealing pressure to be exerted more efficiently than would otherwise be possible.
Patent IL-136020-A0 (IL)
Title: Arrangement for obtaining reliable anchoring of a threaded implant in bone
IPC: A61C8/00
Filed: 1998-11-03
Abstract: In an arrangement for obtaining reliable anchoring of a threaded implant in dentine, a hole is made in the bone substance. In the side wall of the hole it is possible to establish an internal threading which can cooperate with an external threading on the implant. The implant threading is arranged to force the bone substance out in essentially radial directions as a function of the extent to which the implant is screwed into the hole. The threading is arranged to effect greater forcing out of the bone substance at the outer parts of the hole than at the inner parts of the hole. The degree of forcing out is adapted in relation to the softness of the bone in order to achieve the reliable anchoring. Along at least part of the longitudinal direction of the implant, the implant threading can be given a non-circular configuration for the purpose of obtaining improved rotational stability in soft/weak bone.
Patent IL-145292-A0 (IL)
Title: Megavoltage computed tomography during radiotherapy
IPC: G21K5/02
Filed: 2000-03-29
Abstract: Reduced dose megavoltage CT images are obtained using low flux data resulting from leakage through modulating shutters and/or collected by other means and augmented by incomplete high flux data collected during radiation therapy. The ability to construct tomographic projection sets from significantly varying flux rate data is provided by the use of air scans windowed to account for variations in mechanical leaf movement. These methods are also provide a means of imaging the patient entirely during radiation therapy treatments without any additional scan time.
Patent IL-152411-A0 (IL)
Title: Zolpidem hemitartrate
IPC: A61P25/22
Filed: 2001-04-24
Abstract: The present invention provides for novel polymorphs of zolpidem hemitartrate and the preparation of the polymorphs.
Patent IL-174344-A0 (IL)
Title: Implantable device fastening system and methods of use
IPC: A61B17/064
Filed: 2006-03-16
Abstract: A surgical fastening system for implantable devices is disclosed. The implantable device may contain a plurality of fasteners in pre-deployment position, may have a housing fitted over or around fit which contains a plurality of fasteners in pre-deployment position, or may be a part of a two-part system into which it its. Accordingly, the present invention also encompasses a deployment system or tool that optionally positions the implantable device, and which causes the fasteners to move into post-deployment position. The fasteners may be staples, metal loops, coils, springs or hooks formed of biocompatible materials, including shape memory alloys such as NiTi.
Patent IL-177915-A0 (IL)
Title: Fluorescence polarization assay
IPC: G01N33/542
Filed: 2006-09-06
Abstract: Disclosed are methods and systems that use fluorescence polarization to identify compounds that have the ability to bind to, and/or modulate, the activity of the Receptor for Advanced Glycated Endproducts (RAGE). Compounds identified using the methods and systems of the present invention may comprise small organic molecule RAGE antagonists. The small organic molecule RAGE antagonists identified using the methods and systems of the present invention may be used to treat RAGE-mediated diseases, such as, but not limited to, diabetes or Alzheimer's disease.
Patent IL-180892-A0 (IL)
Title: Recirculating vertical wind tunnel skydiving simulator and reduced drag cable for use in wind tunnels and other locations
Filed: 2007-01-23
Abstract: A cable designed for use in applications when it is advantageous to reduce the amount of aerodynamic drag in air caused by the cable without the cable being formed from a multiplicity of a plurality of elongated metal elements twisted together, one of said outer elements having a cross-section which is different to all other outer elements, said all other outer elements defining an outer surface of the line which has a predetermined circumferential length, said one element having a cross-sectional size and shape such that it projects or indents from said outer surface a distance above or below said predetermined circumferential length so as to form a helical ridge or grove around the line, thereby reducing the aerodynamic drag of the cable in air.
Patent IL-182805-A0 (IL)
Title: Methods and compositions for reducing neurodegeneration in amyotrophic lateral sclerosis
Filed: 2007-04-26
Abstract: A composition comprising a clear aqueous solution comprising: 
(a) a first material selected from soluble ursodeoxycholic acid or a sodium salt oftauroursodeoxycholic acid (TUDCA); 
(b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide; 
(c) water, wherein the first material and the carbohydrate both remain in solution for any subset of the range of pH values obtainable in an aqueous system sufficient for a pharmaceutical formulation to remain in solution from preparation, to administration, to absorption in the body;  
for use in the treatment of at least one symptom of a neurodegenerative disease or at least one symptom of a motor neuron disease in a subject.
Patent IL-189571-A0 (IL)
Title: Use of a vascular endothelial cell growth factor-e (vegf-e) antagonist for the preparation of and as medicaments for inhibiting or preventing growth of cancer cells or angiogenesis
IPC: C12P21/08
Filed: 2008-02-18
Abstract: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.
Patent RO-127504-A0 (RO)
Title: Vibrating welding table
Inventor: LUCA MIHAI ALEXANDRU
IPC: B23K11/12
Filed: 2012-01-23
Abstract: The invention relates to a welding table with vibrating working surface whereon the products destined to the welding operation are subjected, during the whole welding and cooling duration, to a field of mechanical oscillations of high amplitudes which stimulate the forced germination of grains formed during solidification of the weld seam and which carries out the stress relieving of the region at high temperatures. According to the invention, the table consists of a metal frame (2) equipped with minimum four resilient elements (3) such as the rubber buffers or metal springs which sustain a vibrating plate (1) made of steel sheet with thicknesses in the range of 10...12 mm, whereon the products (18) to be welded are secured by some mechanical or magnetic stoppers, in the four corners of the vibrating plate (1) there are mounted the left and right resilient systems (4 and 5) for adjusting the resonance frequency, a contact buffer (6) for taking over the vibrations generated by the electrodynamic exciter (7), the spherical surface of the buffer (6) establishing a pointlike contact with the plane surface of the water cooler (8), the electrodynamic exciter (7) is secured on a gliding plate (9) protected by some rubber buffers (10) which may glide vertically on a guide (11), a length-pressure adjusting system (12), the whole metal frame (2) being supported on four legs adjustable in height, placed on the damping rubber buffers (15), the working frequency of the electrodynamic exciter may be in the range of 20 Hz...20 kHz by actuating a low frequency generator (16) whose signals are amplified by a power amplifier (17).
Patent RO-132448-A0 (RO)
Title: Stand of controlled climatic parameters for testing solar converters
Inventor: BURDUHOS BOGDAN-GABRIEL
IPC: G01N25/72
Filed: 2017-11-29
Abstract: The invention relates to a stand of controlled climatic parameters, intended for testing solar converters in various weather conditions, such as fog, dew, hoar-frost, snow, rain, at controlled values of the inside air temperature, humidity, wind velocity, solar radiation. According to the invention, the stand consists of an isothermal climatic chamber (1) maintaining therein an atmosphere of controlled weather parameters, such as temperature, humidity, wind, using a heating/cooling system (8, 9), a moistening/demoistening system (10), a ventilation system (11), a water spraying system (12) wherein there is a system (13) for monoaxial orientation of the solar converter to be tested under the luminous radiation received from outside the climatic chamber (1), from a light source (2), through a window (6) of ultra-clear heated glass (7), the source (2) of artificial light of variable spectrum and intensity consisting of a plurality of UV and VIS lamps (17) which are equally spaced in a vertical plane, on a mobile framework (18), while, for control and monitoring purposes, the stand also comprises a system (3) consisting of a sensorial system placed inside the climatic chamber (1), a central unit for taking over the signals from sensors, for processing data and controlling the operation of the artificial light source (2) and of the systems (8, 9, 10, 11, 12 and 13).