Patent SG-11201804259U-A (SG)
Title: Antibody cytokine engrafted compositions and methods of use for immunoregulation
Inventor: DIDONATO MICHAEL
IPC: C07K14/54
Filed: 2016-12-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DEEM II 11111111111111111111111111111111 RID IIII (10) International Publication Number WO 2017/093947 Al WIPO I PCT (43) International Publication Date 8 June 2017 (08.06.2017) (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) PCT/IB2016/057283 (51) International Patent Classification: C07K 14/54 (2006.01) (21) International Application Number: (22) International Filing Date: 1 December 2016 (01.12.2016) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/263,008 4 December 2015 (04.12.2015) US (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). (72) Inventors: DIDONATO, Michael; Novartis Institute for Functional Genomics, Inc., Dba Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US). KNUTH, Mark; No- vartis Institute for Functional Genomics, Inc., Dba Genom- ics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US). MEEUSEN, Shelly; Novartis Institute for Functional Gen- omics, Inc., Dba Genomics Institute of the Novartis Re- search Foundation, 10675 John Jay Hopkins Drive, San Deigo, CA 92121 (US). SPRAGGON, Glen; Novartis In- stitute for Functional Genomics, Inc., Dba Genomics Insti- tute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US). [Continued on next page] (54) Title: ANTIBODY CYTOKINE ENGRAFTED COMPOSITIONS AND METHODS OF USE FOR IMMUNOREGULATION Fi b Anti-inflammatory Pro-inflammatory Macrophages CM Mans , .2 cells Daa . 2 h rggc CDM T cells 12:22. Giancyrne produrVon -10 Mast cells DcgranuiDia cytaksmsa Denthitip wits Pr io W O 20 17 /0939 47 Al Thl, Th2 (57) : The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell re - sponses, and reducing pro- inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Addi- tionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of produ- cing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other thera- peutics in treating immune related disorder. WO 2017/093947 Al MIDEDIMOMOIDERDEEMOOMOHEOHOHOEMOVOIMIE Published: — with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))