Patent SG-11201803519Y-A (SG)
Title: A solid state form of pladienolide pyridine compounds and methods of use
Inventor: KEANEY GREGG F
IPC: C07D405/06
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 May 2017(26.05.2017) WIPOIPCT (10) International Publication Number WO 2017/087667 A1 (51) International Patent Classification: C07D 405/06 (2006.01) A61P 35/00 (2006.01) A61K 31/4427 (2006.01) (21) International Application Number: PCT/US2016/062525 (22) International Filing Date: (25) Filing Language: (26) Publication Language 17 November 2016 (17.11.2016) English English (30) Priority Data: 62/257,088 18 November 2015 (18.11.2015) US (71) Applicants: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10 Koishikawa, 4-Chome, Bunkyo-ku, Tokyo, 112-8088 (JP). GEARHART, Nicholas C. [US/US]; 2164 Crestview Drive, Durango, Colorado 81301 (US). NAGAO, Satoshi [JP/JP]; c/o Eisai Co., Ltd. Tsukuba Re­ search Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 3002635 (JP). CHAN, Betty [US/US]; 15 Littleton Road #3A, Harvard, Massachusetts 01451 (US). THOMAS, Mi­ chael P. [US/US]; 66 Washington Street, Stoneham, Mas­ sachusetts 02180 (US). (72) Inventors; and (71) Applicants : KEANEY, Gregg F. [US/US]; 34 Robbins Road, Lexington, Massachusetts 02421 (US). WANG, John [US/US]; 2 Governor's Drive, Andover, Massachu­ setts 01810 (US). GERARD, Baudouin [FR/US]; 69A Dartmouth Street, Belmont, MA 02478 (US). ARAI, Kenzo [JP/JP]; c/o Eisai Co., Ltd. Tsukuba Rearch Labor­ atories, 5-1-3 Tokodai, Tsukuba-shi, 3002635 (JP). LIU, Xiang [CN/US]; 10 Marion Street, Winchester, MA 01890 (US). ZHENG, Guo, Zhu [US/US]; 14 Meriam Street, Lexington, MA 02420 (US). KIRA, Kazunobu [JP/JP]; c/o Eisai Co., Ltd. Tsukuba Rearch Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 3002635 (JP). TIYITMA- HAISOON, Parcharee [US/US]; 580 Commonwealth Av­ enue, #606, Boston, MA 02215 (US). PRAJAPATI, Sudeep [NP/US]; 270 Highland Avenue, Apt. 53, Somerville, MA 02143 (US). KOTAKE, Yoshihiko [JP/JP]; C/o Eisai Co., Ltd. Tsukuba Rearch Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki, 3002635 (JP). KANADA SONABE, Regina, Mikie [BR/JP]; c/o Eisai Co., Ltd. Tsukuba Rearch Laboratories, 5-1-3 Tokodai, Tsukuba-shi, 3002635 (JP). MIYANO, Masayuki [JP/JP]; c/o Eisai Co., Ltd. Tsukuba Rearch Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki, 3002635 (JP). MURAI, Norio [JP/JP]; c/o Eisai Co., Ltd. Tsukuba Rearch Laborat­ ories, 5-1-3 Tokodai, Tsukuba-shi, 3002635 (JP). BUO- NAMICI, Silvia [IT/US]; 680 Tremont Street, Apt. 4, Bo­ ston, MA 02118 (US). YU, Lihua [US/US]; 19 Wood Land, Acton, MA 01720 (US). PARK, Eunice, Sun [US/US]; 4 Knowles Fram Road, Arlington, MA 02474 (US). SMITH, Peter, G. [GB/US]; 173a Franklin Street, Arlington, MA 02472 (US). PAZOLLI, Ermira [US/US]; 133 Plain Road, Wayland, MA 01778 (US). LIM, Kian, Huat [MY/US]; 135 Farms Drive, Burlington, MA 01803 (US). (74) Agent: MACALPINE, Jill, K.; Finnegan, Henderson, Farabow, Garrett & Dunner, LLP, 901 New York Avenue, NW, Washington, DC 20001 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) i> l> 00 l> (54) Title: A SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE (57) : The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions compris­ ing at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceo- some and mutations therein are known to be useful. O