Patent SG-11201811221X-A (SG)
Title: Imidazo[1,2-a]pyridine derivatives, methods for preparing the same and use thereof
Inventor: KIM JEONGMIN
IPC: A61K31/397
Filed: 2017-07-04
Abstract: WO 18/0089 29 Al ' ' 4 the use thereof. The imidazo[1,2-a]pyridine derivatives according to the present disclosure have gastric acid secretion inhibitory ac- s tivity, and thus may be effectively used for the prevention or treat- ment of gastrointestinal inflammatory diseases or gastric acid-re- lated diseases. Time after drug administration (min) • Control *Example 6 it Example 7 Example 11 391 2. 1.0 0 50 120 tao 2413 390 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 January 2018 (11.01.2018) WIP0 I PCT Iiiimmommionotioloolosionolomioniou oimIE (10) International Publication Number WO 2018/008929 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/437 (2006.01) CO7D 403/06 (2006.01) A61K 31/397 (2006.01) (21) International Application Number: PCT/KR2017/007055 (22) International Filing Date: 04 July 2017 (04.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10-2016-0085048 05 July 2016 (05.07.2016) KR (71) Applicant: JEIL PHARMACEUTICAL CO.,LTD. [KR/KR]; 343, Sapyeong-daero, Seocho-gu, Seoul 06543 (KR). (72) Inventors: KIM, Jeongmin; 102-802, 21, Simin- ro 66beon-gil, Jungwon-gu, Seongnam-si, Gyeong- gi-do 13258 (KR). LEE, Hyunho; 103-801, 161, Pungdeokcheon-ro, Suji-gu, Yongin-si, Gyeonggi-do 16832 (KR). CHUN, Kwangwoo; 101-506, 1144, Jung- bu-daero, Cheoin-gu, Yongin-si, Gyeonggi-do 17091 (KR). PARK, Chun-Ho; 105-2004, 455-10, Dongbaekjuk- jeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16993 (KR). JANG, Eunsung; 102-704, 26-30, Expo-ro 123beon- gil, Yuseong-gu, Daejeon 34125 (KR). PARK, Yoon- sun; 106-1201, 91, Geumhak-ro, Cheoin-gu, Yongin-si, Gyeonggi-do 17017 (KR). KIM, Joseph; 507, 193-12, Eon- dong-ro, Giheung-gu, Yongin-si, Gyeonggi-do 16988 (KR). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (74) Agent: AHN, So Young; 4th Fl., 344, Seocho-daero, Seo- cho-gu, Seoul 06632 (KR). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = (54) Title: IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USE THEREOF (57) : The present disclosure relates to novel imida- zo[1,2-a]pyridine derivatives, and more particularly to imida- zo[1,2-a]pyridine derivatives having an excellent activity of in- hibiting gastric acid secretion, methods for preparing the same, and [Fig. 1]