baber/WOPTO huggingface dataset:
Patent PT-1919883-E (PT)
Title: N-oxides as prodrugs of piperazine&piperidine derivatives
Inventor: FEENSTRA ROELOF W
IPC: C07D295/00
Filed: 2006-08-21
Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
Patent PT-1974761-E (PT)
Title: Pen-type injector with dose dial sleeve
Inventor: PLUMPTRE DAVID AUBREY
IPC: A61M5/24
Filed: 2004-03-03
Abstract: The invention relates to a drive mechanism for use in a drug delivery device comprising: 
an internal housing having an external helical thread, which internal housing is provided within a main housing; 
a dose dial sleeve (70) having a helical thread engaged with the helical thread of the said internal housing; 
a drive sleeve (30) releasably connected to the said dose dial sleeve (70); 
and a clutch means (60) located between the dose dial sleeve (70) and the drive sleeve (30);  When the dose dial sleeve (70) and the drive sleeve (30) are coupled, both are allowed to rotate with respect to the internal housing.  When the dose dial sleeve (70) and the drive sleeve (30) are de-coupled, rotation of the dose dial sleeve (70) with respect to the internal housing is allowed, whilst rotation of the drive sleeve (30) with respect to the internal housing is not allowed, whereby axial movement of the drive sleeve (30) is allowed so that a force is transferred in the longitudinal direction to the proximal end of the drug delivery device.
Patent PT-2157865-E (PT)
Title: Biscuits and crackers containing reduced levels of saturated fat and method for the manufacture thereof
Inventor: PAARDEKOOPER ROBERT HENDRIKUS
IPC: A21D13/08
Filed: 2008-06-06
Abstract: One aspect of the present invention relates to a method ofpreparingbiscuits or crackers, said method comprising (i) preparing a dough by combining flour, water, leavening agent, a fat blend and optionally further bakery ingredients; and (ii) baking the dough; wherein the fat blend contains at least 30 wt.% of polyunsaturated fatty acids and comprises: 50-85 wt.% of a highly unsaturated oil selected from the group consisting of sunflower oil, soybean oil, rapeseed oil, cottonseed oil, safflower oil, marine oil, corn oil, olive oil, linseed oil and combinations thereof; and 15-50 wt.% of a palm oil fraction having a melting point within the range of 27-38 ºC; and wherein said fat blend is further characterised by a solid fat content at 25 ºC of less than 10 wt.%. The fatblend of the present invention can suitably be used to prepare a biscuit dough or a cracker dough that does not suffer from stickiness. Furthermore, despite the high level of unsaturated fatty acids in the fat blend the biscuits and crackers made with this fat blend exhibit a surprisingly high oxidative stability. Other aspects of the invention relates to a biscuit dough or cracker dough as well as to a baked biscuit or a baked cracker containing the aforementioned fat blend.
Patent PT-669128-E (PT)
Inventor: KINO SHIGEMI
IPC: A61K9/52
Filed: 1993-11-15
Abstract: A sustained-release microsphere produced by enclosing a hydrophobic antipsychotic such as bromperidol or haloperidol in a base comprising a biocompatible polymer such as polylactic acid or a lactic acid/glycolic acid copolymer. It can exhibit a desired pharmacological effect, where a long-term administration is necessary, by injecting once every 1 to 8 weeks instead of every day. As a result, a remarkable improvement can be expected in the compliance during maintenance therapy. In addition, the use of the biocompatible polymer serves to entirely dispense with surgical operations such as implantation, facilitates hypodermic and intramuscular injection just like the case of suspending injection, and can dispense with the widrawal of the microsphere. Furthermore, the microsphere can be administered with little aversion and pain.
Patent PT-699689-E (PT)
Inventor: NEESER JEAN-RICHARD
IPC: C12R1/225
Filed: 1994-08-19
Abstract: The present invention concerns a new branched natural soluble polysaccharide comprising a main chain having repeating side chains which are lactose units, possibly substituted. The present invention also concerns the microorganism by which this branched polysaccharide may be obtained and the food comosition, the cosmetical composition and the pharmaceutical composition comprising said branched polysaccharide and/or microorganism. <MATH>
Patent PT-673197-E (PT)
Inventor: LEE JAMES C
IPC: A01N37/40
Filed: 1993-12-13
Abstract: Pesticidal and fertilizer compositions containing at least one compound of formula I R3C(O)-N(R1)(R2)(I) wherein R1 is hydrogen or a substituted or unsubstituted C1-C6 alkyl group; R2 is hydrogen or a substituted or unsubstituted C1-C6 alkyl group; and R3C(O)- is a substituted or unsubstituted fatty acid residue of 8 to 22 carbon atoms are provided. A method of increasing the effectiveness of a pesticide which comprises applying a pesticide and an amount of a compound of formula I effective to increase the pesticidal activity of the pesticide is also provided. A method for increasing the effectiveness of a fertilizer which comprises applying to a plant in need thereof a fertilizer and an amount of a compound of formula I effective to increase the fertilizing activity of the fertilizer is also described.
Patent PT-694032-E (PT)
Inventor: COMMERCON ALAIN
IPC: C07D417/04
Filed: 1994-04-14
Abstract: A method for preparing 3-hydroxy (3R,4S)-2-azetidinones of general formula (Ia), and the use thereof for preparing taxoids, are disclosed. In general formula (Ia), Ar is an aryl radical.
Patent PT-706398-E (PT)
Inventor: EINARSSON MONICA
IPC: A61K47/14
Filed: 1994-06-16
Abstract: PCT No. PCT/SE94/00595 Sec. 371 Date Dec. 4, 1995 Sec. 102(e) Date Dec. 4, 1995 PCT Filed Jun. 16, 1994 PCT Pub. No. WO95/00152 PCT Pub. Date Jan. 5, 1995The present invention relates to pharmaceutical compositions containing heparin or heparin fragments or their derivatives in combination with one or more glycerol esters of at least one fatty acid as single absorption enhancer. The compositions are useful for oral administration, for administration through mucous membranes or for transdermal administration. The compositions will when necessary contain further physiologically acceptable additives, such as diluents and/or carriers, suitable for the adaptation to oral, buccal, rectal, sublingual, nasal, subcutaneous or transdermal administration. The composition according to the invention provide excellent absorption and bioavailability without employing additional enhancers or promoters.
Patent PT-712275-E (PT)
Inventor: HANS HOPP DR
IPC: A01M21/00
Filed: 1995-06-01
Abstract: A process is disclosed for treating plants in agricultural and non-agricultural land by injuring the aerial plant parts with a blasting material. Plant treatment substances applied on the aerial parts of the plants before or during injuring are immediately absorbed by the plants (23) through their superficial lesions. Also disclosed are a device and a finely powdered blasting material for carrying out this process.
Patent PT-732093-E (PT)
Inventor: KARLIN MICHELSON GARY
IPC: A61B19/00
Filed: 1996-02-02
Abstract: The present invention discloses a spinal fusion implant that is at least partially cylindrical, made of material appropriate for human implantation and having preferably, but not necessarily, one closed end and one end capable of being closed, such that an internal chamber can be filled and hold any natural or artificial osteoconductive, osteoinductive, osteogenic, or other fusion enhancing material. The partially cylindrical implant directly participates and is incorporated in the ensuing fusion. In the preferred embodiment, the implant of the present invention relies on surface roughenings of the outer surface to enhance its stability and resist dislodgement from within the disc space between two adjacent vertebrae. The implant of the present invention incorporates at its rear end, an engagement means to facilitate insertion or extraction of the implant. The implant may be filled with, coated with, and/or composed of, fusion promoting substances. Finally, the implant of the present invention does not require rotation for its insertion and can be seated by linear advancement.
Patent PT-832881-E (PT)
Inventor: CROWELL THOMAS ALAN
IPC: A61K31/5375
Filed: 1997-09-25
Abstract: The present invention provides compounds of formula I <CHEM>  wherein   R1 is -H, -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl), -OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R2 is -OH, -O(C1-C4 alkyl), -OCO(C1-C6 alkyl),-OCOO(C1-C6 alkyl), -OCOAr, -OCOOAr, or -OSO2(C2-C6 alkyl); R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-l-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; and   n is 2 or 3; or a pharmaceutically acceptable salt or solvate thereof.
Patent PT-835266-E (PT)
Inventor: ABRAHMSEN LARS
IPC: A61K47/48
Filed: 1997-03-26
Abstract: A novel conjugate comprises a target seeking moiety and a modified wild type superantigen; the modified superantigen retains its ability to activate a subset of T cells, even though 1 or more wild-type amino acid residues in at least 1 region which functions in determining binding to T cell receptor (TCR)and activation of a subset of T cells has/have been replaced. Also claimed is the use of a modified superantigen as above, optionally as part of a conjugate with a target seeking moiety, for activating the immune system to treat a mammalian disease. Also new is a pharmaceutical composition comprising a modified antibody (preferably a Fab fragment fused to a peptide moiety providing activation of T cells in V~b specific manner) in which cysteines providing for interchain cysteine linkages in the native antibody have been replaced (preferably by serine residues) to prohibit cystine formation.
Patent PT-925395-E (PT)
Inventor: DVORAK JOSEF
IPC: D03D49/12
Filed: 1997-07-24
Abstract: A device for controlling stationary and rotating warp threads for the production of leno fabrics on a textile machine comprises reversibly moveable needles (3) with eyes (4) for guiding the stationary warp threads (19), vertically adjustable guide means (10-13) situated in front of said needles and having a member (10) with oblique slots (12) for the passage of the rotating warp threads, the warp threads being displaceable within said oblique slots, a guide member (20) for the stationary warp thread (19) coupled with the needles (3), and compensation means (15) for adjusting tension of the rotating warp threads. <IMAGE>
Patent PT-946799-E (PT)
Inventor: LINZ HANS
IPC: D01D5/16
Filed: 1997-12-11
Abstract: PCT No. PCT/CH97/00463 Sec. 371 Date Apr. 7, 1999 Sec. 102(e) Date Apr. 7, 1999 PCT Filed Dec. 11, 1997 PCT Pub. No. WO98/28473 PCT Pub. Date Jul. 2, 1998The method of producing an industrial yarn at a production speed of from 3000 to 6000 m/min includes melt-spinning a plurality of polyester filaments; stretching a thread made from the filaments by means of a delivery assembly (1) and a drawing roller system (2); providing at least one thread-braking device (3) including at least one deflecting roller (31, 32) between the delivery assembly (1) and the drawing roller system (2); deflecting and decelerating the thread between the delivery assembly and the drawing roller system by means of the at least one thread-braking device (3) and looping the thread only once around the at least one deflecting roller (31,32) of the at least one thread-braking device (3). The at least one deflecting roller (31, 32) is braked to a circumferential speed (v3) given by the following formula v3=v1+(v2-v1)* F, wherein 0.5</=F<1, v1=the delivery assembly speed and v2=the drawing roller system speed.
Patent PT-948630-E (PT)
Title: Cloning and characterization of napsin, an aspartic protease
Inventor: LIN XINLI
IPC: C12N15/09
Filed: 1997-11-20
Abstract: A previously unknown aspartic protease capable of cleavage of proteins by hydrolysis, referred to herein as "napsin", has been cloned from a human liver library. Two cDNA clones have been cloned, sequenced and expressed. These encode isozymes of the protease, referred to as "napsin A" and "napsin B". The gene has also be obtained and partially sequenced. A process for rapid purification of the enzyme using immobilized petpstatin has also been developed, and enzyme isolated from human kidney tissue. Polyclonal antibodies to the enzymes have been made which are also useful for isolation and detection of the enzyme. Similarities to other aspartic proteases, especially cathepsin D, establish the usefulness of the enzyme in diagnostic assays as well as as a protease. Either or both the amount or type of napsin expressed in a particular tissue can be determined using labelled antibodies or nucleotide probes to the napsin.
Patent PT-953080-E (PT)
Inventor: SANDQUIST KENT K
IPC: A01C15/00
Filed: 1998-10-15
Abstract: The invention refers to a method for black liquor gasification in recovery boilers, of the type having a lower portion, referred to as a lower furnace and an upper portion, referred to as an upper furnace, black liquor sprayers for introduction of black liquor provided in the boiler above the lower furnace, and a number of combustion air levels, whereby the invention incorporates adding oxygen enriched air to the combustion air or directly into the lower furnace at at least one air level underneath the liquor sprayers for the purpose of creating the best possible reducing conditions in the lower furnace, redistributing from the lower furnace combustion air not needed therein following the addition of oxygen enriched air, thereby significantly reducing upward gas velocity underneath the black liquor sprayers, and introducing the redistributed combustion air in the upper furnace, thereby creating the reducing conditions and a controlled temperature in the lower furnace for emission control.
Patent PT-1049802-E (PT)
Inventor: ALAN LEE MARTIN
IPC: C12Q1/6823
Filed: 1998-11-27
Abstract: A method for determining a characteristic of a sequence, said method comprising;  (a) adding to a sample suspected of containing said sequence, a probe specific for a target sequence and a DNA duplex binding agent, said probe comprising a reactive molecule able to absorb fluorescence from or donate fluorescent energy to said DNA duplex binding agent,  (b) subjecting said sample to conditions under which the said probe hybridises to the said sequence,  (c) monitoring fluorescence from said sample and determining a particular reaction condition, characteristic of said sequence, at which fluorescence changes as a result of the hybridisation of the probe to the sample or destabilisation of the duplex formed between the probe and the target nucleic acid sequence.    A nucleic acid detection system utilising a similar operating procedure is also described and claimed.
Patent PT-957137-E (PT)
Inventor: PEDEMONTE RONALD P
IPC: C09B67/22
Filed: 1999-05-07
Abstract: Dye mixture contains disazo dye(s) (I) and monoazo dye(s) (II) of the 1-amino-7-(vinylsulfonylphenylazo)-8-naphthol-3,6-disulfonic acid type with a 1,3,5-triazine bridge or substituent. Dye mixture contains disazo dye(s) of formula (I) and monoazo dye(s) of formula (II) of the 1-amino-7-(vinylsulfonylphenylazo)-8-naphthol-3,6-disulfonic acid type with a 1,3,5-triazine bridge or substituent: D-N=N-Z-NH-T-NH-Z-N=N-D' (I) D-N=N-Z-NH-T'-NH-D' (II) D, D' = vinylsulfonyl-phenyl or -sulfophenyl or precursor groups with the vinylsulfonyl (precursor) group in the meta- or para-position to the azo or amino group; Z = 8-hydroxy-3,6-disulfonaphthalen-1,7-diyl groups with the azo (-N=N-) group at the 2-position; and T, T' = 2-substituted 1,3,5-triazin-4,6-diyl groups. The full definitions are given in the DEFINITIONS (Full Definitions) Field.
Patent SG-76588-G (SG)
Title: Carbohydrate-metal bicarbonate complexes useful as carbonating agents
IPC: A23L2/40
Filed: 1988-11-16
Abstract: Dry, stable carbonating agents comprised of a carbohydrate/metal bicarbonate complex are disclosed. The complex is prepared by reacting a carbohydrate with a metal hydroxide or oxide at a temperature not exceeding 25 DEG C to form a carbohydrate/metal hydroxide adduct to which carbon dioxide is then introduced to form the complex. The complex is then immediately dried, preferably by freezing it to below its eutectic temperature and freeze dried. The carbonating agents are particularly useful as components of dehydrated beverage powders. Upon rehydration, the complex releases carbon dioxide and carbonates the beverage.
Patent IE-34931-L (IE)
Title: Mould stripping machine.
IPC: B29C37/00
Filed: 1971-02-04
Abstract: A machine for automatically stripping thin, flexible molded products from their molds on a continuously moving conveyor comprises, in essence, a movable array of arm pairs for clamping onto the molds, each arm having a pair of fingers for clamping onto a cuff or bead at the bottom of the molded product. The array of arms is attached to a movable carriage on a track parallel to the conveyor. A pneumatically actuated piston rod raises and lowers the array. Mechanical drive means are provided for engaging the carriage when the arm pairs are centered over the molds and for driving it at the same speed at the conveyor. As the carriage moves, it activates a series of switches which lower the array, clamp the arms onto the molds, clamp the fingers onto the beads, spread the arms again, and raise the array. A shuttle platform is driven under the raised array, and the stripped products are released. The carriage and the shuttle are then returned to their initial positions for a repetition of the cycle.
[US3655317A]
Patent IE-880190-L (IE)
Title: Built nonaqueous liquid detergent.
IPC: C11D1/72
Filed: 1988-01-26
Abstract: A liquid heavy duty laundry detergent composition comprising a suspension of builder salt in liquid nonionic surfactant in which the pourability and physical stability of the composition is improved by the addition of small amounts of an alkaline earth metal or zinc salt of higher fatty acid, especially magnesium, calcium and zinc distearate. The yield stress is reduced and the pourability of the composition is improved especially at low concentrations of the alkaline earth metal or zinc salt.
[US4839084A]
Patent IE-900242-L (IE)
Title: Preparation of 2-chloropropionate esters
IPC: C07C69/63
Filed: 1990-01-22
Abstract: Process for the preparation of an optically active 2-chloropropionate ester of formula: <IMAGE> R being an optionally substituted hydrocarbyl residue, from an optically active lactate of formula <IMAGE> the said process being characterised in that the said lactate (I) is brought into contact with phosgene and a compound chosen from aliphatic amides, aliphatic lactams and aliphatic ureas. Use of the process for the manufacture of intermediates which are useful in the agrochemical industry.
Patent IE-880302-L (IE)
Title: Polypeptides
IPC: C07K14/575
Filed: 1988-02-04
Abstract: Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: Q<1>-CO-R2-R3-Ala4-Ile5-Phe6-Thr7-R8-Ser9-R10-Arg11-R12-R13-R14-R15-Gl n16-R17-R1 8- Ala19-Arg20-Lys21-Leu22-R23-R24-R25-Ile26-R27- R28-NH-Q<2> wherein Q<1> is an omega or alpha-omega substituted alkyl, Q<2> is a lower omega-guanidino-alkyl group. R2 is Ala,D-Ala,or D-N-Methyl-Ala R3 is Asp,D-Asp,Glu,or D-Glu R8 is Asn,D-Asn,Ser, or D-Ser R10 is Tyr or D-Tyr R12 is Lys, D-Lys Arg or Orn R13 is Val or Ile R14 is Leu or D-Leu R15 is Gly,N-Methyl-Gly, or D-Ala R17 is Leu or D-Leu R18 is Tyr or Ser R23 is Leu or D-Leu R24 is Gln or His R25 is Asp,D-Asp,Glu, or D-Glu R27 is Met,D-Met,Ala,Nle,Ile,Val,Nva,Leu R28 is Asn or Ser The peptides as well as nontoxic salts thereof may be administered to animals, including humans and cold-blooded animals, to stimulate the release of GH and may be used diagnostically.
[EP0277626A2]
Patent IE-38909-L (IE)
Title: Steroid carbamates and allophanates.
IPC: A61K31/565
Filed: 1974-02-20
Abstract: 1458372 Steroid carbamates amd allophanates LEO AB 22 Feb 1974 [5 March 1973] 10613/73 Heading C2U The invention comprises compounds of formulae wherein m is 0 or 1; n is 1 or 2; R<SP>1</SP> is #- or γ- halo-C 2-4 -alkyl (where "halo" is Cl, F or Br); R<SP>2</SP> is H, R<SP>1</SP> or C 1-4 alkyl or is a phenyl or C 5-6 cycloalkyl radical optionally bearing 1 or 2 halo, C 1-4 alkyl or C 1-4 alkoxy substituents; and St is an optionally substituted gonane radical containing up to 40 carbon atoms inclusive and 0 to 4 double bonds, and is connected to the carbamate or allophanate group at one or two of positions 3, 11, 16, 17 and 21. Compounds II are disclaimed when St is a 21-yl radical while m is 0. Exemplified compounds are of the androstane, estrane, 13-ethylgonane, pregnane, cholestane and ergostane series. Compounds I are prepared by nitrosating compounds II or reducing compounds III. Compounds III are prepared by nitrating compounds II. Compounds II and subclasses thereof of formulae are prepared from or via compounds of formulae by the following reactions: Compounds II are interconvertible by reduction of 3- or 17-oxo, esterification of 3#-, 17#- or 21-hydroxy, etherification of 17#- hydroxy, and hydrolysis of 17,21-acetonide. Compounds V, VI and VIII are prepared from compounds IV by reaction with an appropriate carbonyl halide or isocyanate. Androstenolone 3 - (N - ethyl - N - nitrosocarbamate) is prepared by nitrosating the corresponding N-ethylcarbamate; and androstenolone 3 - [N - (2 - chloroethyl) - N - methylcarbamate] is prepared from the corresponding 3-chloroformate by reaction with an appropriate amine. Compounds I are credited with anticancer and antitumour activityand possibly also estrogenic, androgenic, anabolic, gestogenic, corticoid, thymolytic and progestational activities, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, topical, vaginal and rectal administration.
[GB1458372A]
Patent IE-32711-L (IE)
Title: Electric air conditioner
IPC: F24F3/16
Filed: 1969-03-31
Abstract: Wall means defines an enclosed air-conditioning space and is connected to ground potential. At least one electrode is carried by the wall means electrically insulated therefrom and is connected to a positive potential so that an electrostatic field is established between the electrode and the wall means. Further there is provided means operative for maintaining the relative humidity of the air in the enclosed space at a substantially constant level.
[US3680281A]