baber/WOPTO huggingface dataset:
Patent EA-006096-B1 (EA)
Title: Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors
Inventor: SURLERAUX DOMINIQUE LOUIS NEST
IPC: C07D277/82
Filed: 2002-02-14
Abstract: The present invention concerns the compounds having the formula (I), N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are independently H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het<1>, Het<2>; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C(=O)-, -O-C(=O)-, -NR8C(=O)-, -O-C1-6alkanediyl-C(=O)-, -NR8-C1-6alkanediyl-C(=O)-, -S(=O)2-, -O-S(=O)2-, -NR8-S(=O)2; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 H, C1-4alkylOC(=O), carboxyl, aminoC(=O), mono- or di(C1-4alkyl)aminoC(=O), C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; A is C1-6alkanediyl, -C(=O)-, -C(=S)-, -S(=O)2-, C1-6alkanediyl-C(=O)-, C1-6alkanediyl-C(=S)- or C1-6alkanediyl-S(=O)2; R5 is H, OH, C1-6alkyl, Het<1>C1-6alkyl, Het<2>C1-6alkyl, optionally substituted aminoC1-6alkyl; R6 is C1-6alkoxy, Het<1>, Het<1>O, Het<2>, Het<2>O, aryl, aryloxy, C1-6alkyloxycarbonylamino or amino; and in case -A- is other than C1-6alkanediyl then R6 may also be C1-6alkyl, Het<1>C1-4alkyl, Het<1>oxyC1-4alkyl, Het<2>C1-4alkyl, Het<2>oxyC1-4alkyl, arylC1-4alkyl, aryloxyC1-4alkyl or aminoC1-4alkyl; whereby each of the amino groups in the definition of R6 may optionally be substituted; R5 and -A-R6 taken together with the nitrogen atom to which they are attached may also form Het<1> or Het<2>. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.
Patent EA-008137-B1 (EA)
Title: Combination therapy for the treatment of cancer
Inventor: MASFERRER JAIME
IPC: A61K31/415
Filed: 2002-08-15
Abstract: The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitor in combination with a selective cyclooxygenase inhibitor, in particular cyclooxygenase-2 selective inhibitor, wherein said inhibitor is 5-[5-fluoro-2-oxo-1.2-dihydroindol-3-ylidenemethyl-1H-pyrrole-3 carboxilic acid (2-diethylaminoethyl)amid or a pharmaceutically acceptable salt thereof and said cyclooxygenase-2 selective inhibitor is 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] phenylsulfonamide (celioxyb) or a pharmaceutically acceptable salt.
Patent EA-008022-B1 (EA)
Title: Method for topical use of dapsone for the treatment of ache
Inventor: OSBORNE DAVID W
IPC: A61P17/10
Filed: 2002-03-18
Abstract: The present invention relates to a method of treating acne by topically applying a dermatological composition comprising dapsone. In addition to inflammatory lesions, the compositions also treats non-inflammatory acne. The composition is formulated to include dapsone in a both a dissolved and microparticulate state.
Patent EA-008446-B1 (EA)
Title: Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
Inventor: RAULT SYLVAIN
IPC: A61P9/10
Filed: 2003-11-04
Abstract: The invention concerns compounds of formula (I),wherein:Rrepresents a hydrogen, halogen atom, an alkyl, polyhalogenoalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkylaminocarbonyl group;Rrepresents a hydrogen atom, an alkyl, aryl group optionally substituted, heteroaryl optionally substituted or a R-C(X) group,Rrepresenting an alkyl, alkoxy, amino, alkylamino, dialkylamino, aryl optionally substituted or heteroaryl group;X represents an oxygen atom, a sulphur atom, or a NRgroup, wherein Rrepresents a hydrogen atom or an alkyl group;Rrepresents a hydrogen atom or an alkyl group;n represents an integer between 1 and 6 inclusively,Rhas the following meaningsortheir enantiomers, diastereoisomers, as well as their addition salt to a pharmaceutically acceptable acid or base.The invention is useful for preparing medicines.
Patent EA-010021-B1 (EA)
Title: Process for the preparation of metal salts of medium –chain fatty acids
Inventor: DUCEPPE JEAN-SIMON
IPC: C07C51/41
Filed: 2004-07-23
Abstract: A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
Patent EA-010079-B1 (EA)
Title: Thruster pig
Inventor: KINNARY KEIJO J
IPC: E21B23/08
Filed: 2005-06-23
Abstract: Thruster pig for sending through a pipe from an entrance facility to a receiving location, for servicing or monitoring, by pumping a thrusting fluid into the pipe to force the pig forwards into the pipe, said thruster pig comprising: a body having a front end and a back end, which back end includes a reaction surface to which said thrusting fluid applies a motive force, said body having a diameter slightly smaller than the inner diameter of the pipe, a seal circumferentially arranged on the pig to seal between said body and said pipe, a connector for releasable connection of a return flow line to the pig, said connector including a shifting mandrel that is activated to open the connector by pumping a ball through the return flow line, said ball being retained in the return flow line after opening the connector, a blanking device arranged to blank a bore left as the return flow line is disconnected; such that said thruster pig and any connected servicing or monitoring equipment is operable by pumping a fluid into the annulus between the pipe and the return flow line while returning fluid through said return flow line as required to maintain a differential pressure over said pig to urge said pig forwards through the pipe, while at any point said return flow line can be disconnected from the pig and retrieved to the entrance end and the blanked pig can be urged forwards to a pig receiving location by pumping or directing fluid into the pipe. A thruster pig system for hydrate removal is an embodiment of the invention.
Patent EA-010734-B1 (EA)
Title: Medicament normalizing blood vessel functions, and method for preparing thereof
Inventor: KHAVINSON VLADIMIR KHATSKELEVICH
IPC: A61P9/14
Filed: 2007-03-21
Abstract: A number of inventions relates to a medicament and method for preparing thereof using animals' organs, in particular, to a medicament normalizing blood vessel functions, which is a medical preparation for parenteral administration as solution of a peptide complex, a low-molecular fraction content being from 70 to 90% with a molecular mass comprising the peptide components within 72 to 678 Da, peptide concentration being 2.5÷2.9 mg/ml and to a method for preparing thereof from calf blood vessels aged less than 12 month or pigs by extracting acetic acid in the presence of zinc chloride; providing repeated deposition of formed homogenized deposition by twofold volumes of acetone at least two times and subsequent washing through a nutsch filter by twofold volumes of acetone; obtaining an aqueous solution of extract, polypeptide concentrate being 2.5÷2.9 mg/ml; centrifuging, filtering thereof with subsequent ultra-filtration purification at the apparatus with counter pressure not exceeding 1.0 kgs/cmusing materials with retention 15000 Da and adding glycocol in the ultrafiltrate to the final concentration 10÷20 mg/ml at pH=5.6÷6.6 mg/ml and subsequent sterile filtration, ampoulation and autoclaving for 8 minutes at 120°C and atmospheric pressure 1.1 kgs/cm, which provides stability of the medicament and preserving therapeutic effectiveness thereof.
Patent EA-013305-B1 (EA)
Title: Mid-seal for expandable connections
Inventor: SIVLEY ROBERT S IV
IPC: F16L37/24
Filed: 2006-07-25
Abstract: An expandable tubular connection includes a pin member and a box member. The pin member includes a pin thread formed on a small step and a large step and a first seal surface formed between the small step and the large step. The box member includes a box thread formed on a small step and a large step and a second seal surface formed between the small step and the large step. The pin thread and the box thread are wedge threads. Upon a selected make-up of the pin member with the box member a selected gap exists between the first seal surface and the second seal surface. The gap is selected such that, when plastically radially expanded by a selected amount, a seal is formed between at least a portion of the first seal surface and the second seal surface.
Patent EA-013589-B1 (EA)
Title: Protective package for precious stones, e.g. diamonds, pearls, coins, postage stamps and the like
Inventor: BOBOREKO ALEXANDER GEORGIEVICH
IPC: A45C11/16
Filed: 2008-11-20
Abstract: This invention concerns containers, packs, safety cases and the like for precious stones such as diamonds, pearls, coins, medals, ingots and other valuable articles having protective properties and capable of detecting (authorized and unauthorized) access to the above identified articles. The present safety case comprises an upper element and a lower element made of a transparent polymer material. The upper element of the case is provided with at least one transparent housing made, for instance, in the form of a cell for placing at least one of the above identified articles. Moreover, the case comprises a decorative imprint placed on the upper face of the upper element of the case and an irreparably destroyed layer placed on the inner face of the lower element of the case and made, for instance, in the form of a holographic coating for detecting an opening attempt and protecting the case against counterfeiting. The upper and the lower elements of the case are adhesively bonded to each other by means of the irreparably destroyed layer. According to the present invention between the decorative imprint and the upper face of the upper element there is self-adhesive laminated paper, and the irreparably destroyed layer comprises at least one transparent area formed by the double laminate and placed under the transparent housing of the upper element of the case, the decorative imprint and the self-adhesive laminated paper overlapping the irreparably destroyed layer except for its transparent area. Moreover, the lower element of the case is made of the thickened laminate, as such a 200-250 micrometer thick laminate is used. The self-adhesive laminated paper is provided with protective properties, as such printing by special inks and/or fibers visible under ultraviolet rays, and the shape and size of the double laminate in the plan correspond to within 0.1 mm to the shape and size of the opening in the irreparably destroyed layer.
Patent EA-018707-B1 (EA)
Title: Pleuromutilin derivatives for the treatment of diseases mediated by microbes
Inventor: MANG ROSEMARIE
IPC: A61K31/215
Filed: 2008-03-19
Abstract: A compound of formula (I)wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and Rare in vicinal position (if m=0 then Ris in position 2', and if m=1 then Ris in position 1'); R is ethyl or vinyl; Ris hydrogen or (C)alkyl; Ris hydrogen or (C)cycloalkyl, or unsubstituted (C)alkyl, or (C)alkyl substituted by one or more of such as hydroxy; preferably one or two, methoxy, halogen atom, (C)cycloalkyl, or Rand Rtogether with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e.g. selected from N or O, or Ris hydroxy and Ris formyl; Ris OH, OR, a halogen atom, or with the proviso that Ris bound to position 2', Rrepresents -O-(CH)-O- with p equal to 2 or 3; Ris unsubstituted (C)alkyl or (C)cycloalkyl.
Patent EA-020146-B1 (EA)
Title: Apparatus for pyrolysis of carbon-containing materials and process therefor
Inventor: MALIK IVAN KONSTANTINOVICH
IPC: C10B53/02
Filed: 2011-08-23
Abstract: The invention relates to pyrolysis of carbon-containing materials and can be used for example for treatment of lump wood wastes or briquetted wastes of vegetable origin to produce wood charcoal. An apparatus is developed for pyrolysis of carbon-containing materials, comprising a furnace unit, at least one working chamber adapted to be operated for both drying and pyrolysis of initial feedstock, at least a chimney flue, wherein at least one working chamber is adjustably communicated with the furnace unit and, with at least a chimney flue via channels directing streams of gaseous products of drying and pyrolysis and, at least one working chamber is equipped with a means for circulating furnace gas, the means communicates with the furnace unit, and at least one feed stock container adapted to locate it in the working chamber, wherein the means for circulation furnace gases is an isolated heat exchanger passing through at least one working chamber right near the feed stock container. A method for pyrolysis of carbon-containing materials comprises preliminary preparation of feed stock, loading the feed stock into containers, arrangement of the containers in at least one working chamber of the apparatus having an adjustable communication of at least one working chamber with the furnace unit and with at least one chimney flue, heating the feed stock in at least one working chamber providing drying and pyrolysis of the material with emission of vapor and pyrolysis gases, discharge of pyrolysis gases for afterburning, unloading containers with finished product from working chambers, characterized in that heating of feed stock is provided by passing flue gases through at least one isolated heat exchanger passing through at least one working chamber right near the feed stock container.
Patent EA-022283-B1 (EA)
Title: Pharmaceutical comprising benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride
Inventor: RUDKO ADOLINA PETROVNA
IPC: A61K45/06
Filed: 2011-02-15
Abstract: The invention relates to a pharmaceutical including benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride in the monohydrate form or in unhydrated form. The pharmaceutical further comprises dimethyl[3-(myristoylamino)propyl]ammonium oxide and/or dimethyl[3-(myristoylamino)propyl]amine in the appropriate pharmaceutical solvent.
Patent EA-022809-B1 (EA)
Title: Conversion of hydrogen bromide to elemental bromine
Inventor: WAYCUILIS JOHN J
IPC: C01B7/09
Filed: 2010-06-30
Abstract: A method is provided for converting hydrogen bromide to elemental bromine. A portion of an initial hydrogen bromide-rich gas is thermally oxidized at a thermal oxidation temperature to produce a first fraction of elemental bromine and a remainder of the initial hydrogen bromide-rich gas. At least a portion of the remainder of the initial hydrogen bromide-rich gas is catalytically oxidized at a lower catalytic oxidation temperature to produce a second fraction of elemental bromine.
Patent EA-020390-B1 (EA)
Title: Benzodiazepine bromodomain inhibitor
Inventor: GOSMINI ROMAIN LUC MARIE
IPC: C07D487/04
Filed: 2010-08-06
Abstract: The present invention relates to a benzodiazepine compound of formula (I), processes for its preparation, pharmaceutical compositions containing such a compound and to its use in therapy.
Patent EA-025773-B1 (EA)
Title: Method of making fibers bound by cured polymeric binder, composition and composite wood board
Inventor: APPLEY CHARLES
IPC: C08G16/00
Filed: 2011-05-07
Abstract: A binder comprising the products of reducing sugar and primary polyamine is disclosed. The binder is useful for consolidating loosely assembled fibers. Uncured fibrous products comprising fibers in contact with reducing sugar and primary polyamine are disclosed. The binder composition may be cured to yield a fibrous product comprising fibers bound by a cross-linked polymer. Further disclosed are methods for binding fibers with the reducing sugar and primary polyamine based binder.
Patent EA-024168-B1 (EA)
Title: Method for preparing flexible stone claddings having natural surface
Inventor: SASVARI GABOR
IPC: E04F13/14
Filed: 2011-08-12
Abstract: The subject of the invention is method for preparing flexible stone claddings having natural surface, which method makes it possible, that thin and flexible stone claddings can be created, which are of identical surface shaping with stone claddings created by nature. During the method according to the invention a definite color and quantity of coloring agent (5) from a color feeder (4) is fed onto the crushed stone (3) filled into more then one mixing container (1), then after having mixed them, the colored crushed stones (6, 7, 8) and in case of demand, dark crushed stone (22) are layered in a sliding unit (9) in reclined state, then after having mounted the sliding unit (9), the intermingled colored crushed stone (10) is produced by the slight sliding of the colored crushed stones (6, 7, 8) and in given case the dark crushed stone (22), then the intermingled colored crushed stone (10) is poured into a work box (11) situated at α angle, provided with covering falsework (12), then the filled work box (11) is moved into almost horizontal position after having fixed the closing element (14) on it, and after having removed the covering falsework (12) from the work box (11), binding material (16) is spread in thickness V from the disperser head (15) onto the intermingled colored crushed stone (10), forming this way the layer of stone surface (17), then a carrier material (18) is laid onto the layer of the stone surface (17), saturated with binding material (16), then with the help of the disperser head (15) binding material (16) is spread onto the carrier material (18) forming this way the back layer (19).
Patent EA-030828-B1 (EA)
Title: Human anti-cd27 antibodies, methods and uses
Inventor: CHEN JOHN
IPC: A61K39/395
Filed: 2013-03-14
Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27, including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
Patent EA-030105-B1 (EA)
Title: Disposable pull-on diaper
Inventor: HASHIMOTO TATSUYA
IPC: A61F13/496
Filed: 2013-06-05
Abstract: The present invention aims to provide a disposable pull-on diaper improved so that the diaper may be conveniently put on the wearer's body. Each of leg side flaps (42) of a crotch panel (14) has an outer side region (91) and an inner side region (92). In the lowest region (70) of the crotch region (4), the outer side region (91) and the inner side region (92) respectively have a dimension of at least 10 mm in a transverse direction (X) wherein the inner side region (92) extends in a longitudinal direction (Y) and the outer side region (91) extends in the transverse direction (X) from the inner side region (92).
Patent EA-029991-B1 (EA)
Title: Vehicle
Inventor: LEIRIKH ANATOLY ANDREEVICH
IPC: F41H7/04
Filed: 2016-04-19
Abstract: The technical solution is related to transport machine building, in particular, to special-purpose land vehicles, e.g., military motorcars, tanks, armoured fighting vehicles, and concerns protection of crew members against the effect of adverse blast factors in case of blowing up by mines, ground bombs or self-made explosion devices. The vehicle comprises a bottom, a top section, a seat arranged in the inner space of the vehicle, the seat being located remotely from the bottom and being linked to the top section of the vehicle by means of a holding device. The novel feature is provision of the holding device with a flare cartridge connected to a sensor that is mounted on the bottom and responses to peak acceleration caused by a blast wave under the vehicle bottom. The technical result is better protection of crew members against severe injuries due to exposure to peak acceleration caused by a blast wave under the vehicle bottom.
Patent EA-037386-B1 (EA)
Title: Device for positioning and securing a rail on a sleeper
Inventor: BARRESI FRANCESCO
IPC: E01B9/38
Filed: 2014-04-10
Abstract: The invention relates to a device for positioning and securing at least one rail (1) on a sleeper (2), comprising two angle guides (3, 4) positioned so as to clamp the rail (1), pressing against each of the axial edges of the foot of the rail (1); a positioning baseplate (5) having an upper face on which the rail (1) is mounted, said baseplate (5) being intended to form an interface between the sleeper (2) and the rail (1); and two maintaining elements (6, 7) positioned on each side of the angle guides (3, 4) in order to maintain the angle guides (3, 4) pressed against the edges of the foot of the rail (1). At least one of the maintaining elements (6, 7) of the device comprises an interaction surface, on the face that is intended to press against the angle guides (3, 4), said interaction surface being designed to facilitate the insertion of a shim (8, 9) of the device between the maintaining element (6, 7) and the corresponding angle guide (3, 4).
Patent EA-032102-B1 (EA)
Title: Aurora a kinase inhibitor
Inventor: HENRY JAMES ROBERT
IPC: A61P35/00
Filed: 2015-11-06
Abstract: The present invention provides an aminopyridine compound selected from the group consisting of (2S,4S)-1-[(3-chloro-2-fluoro-phenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methyl-piperidine-4-carboxylic acid:and (2R,4R)-1-[(3-chloro-2-fluoro-phenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methyl-piperidine-4-carboxylic acid:or a pharmaceutically acceptable salt thereof, that inhibit Aurora A and, therefore, may be useful in treating cancer.
Patent EA-031968-B1 (EA)
Inventor: TSETI IOULIA
IPC: C07K14/47
Filed: 2015-10-22
Abstract: В изобретении в целом описан новый способ получения комплексов железа(II) с N-ацетил-L-аспартилированным казеином. Продукт, который можно получить способом, предлагаемым в настоящем изобретении, можно безопасно использовать для населения в целом или для животных при лечении дефицита железа. Способ, предлагаемый в настоящем изобретении, включает стадии (a) реакции казеина с N-ацетил-L-аспартилхлоридом с получением N-ацетил-L-аспартилированного казеина, (b) последующей реакции N-ацетил-L-аспартилированного казеина с хлоридом железа(III) и (c) получения комплекса железа(III) с N-ацетил-L-аспартилированным казеином.
Patent EA-035778-B1 (EA)
Title: Catalyst supports
Inventor: ANTONINI ALEJANDRO MARTIN
IPC: B01J35/02
Filed: 2016-07-12
Abstract: A method for preparing a silica-modified catalyst support is described comprising: (i) applying an alkyl silicate solution to a porous support material in an amount to produce a silica content of the silica-modified catalyst support, expressed as Si, in the range 0.25 to 15 wt.%, (ii) drying the resulting silicate-modified support and recovering a first alcoholic solution, (iii) optionally treating the dried silicate-modified support with water, drying the resulting water-treated support and recovering a second alcoholic solution, and (iv) calcining the dried material to form the silica-modified catalyst support, wherein the first alcoholic solution contains 10 vol.% water and at least a portion of the first alcoholic solution is mixed with alkyl silicate to form the alkyl silicate solution.