baber/WOPTO huggingface dataset:
Patent WO-0183448-A2 (WO)
Title: Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo[3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo[e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo[f]chinolin-derivaten für eine selektive krebstherapie
Inventor: TIETZE LUTZ F
IPC: C07D209/04
Filed: 2001-05-02
Abstract: Die Chemotherapie maligner Tumore ist durch die meist geringe Differenzierung der verfügbaren Zytostatika zwischen normalem und malignem Gewebe stark eingeschränkt. Um eine Verbesserung der Selektivität bei der Krebstherapie zu erreichen, wurden neuartige Prodrugs von 6-Hydroxy-2,3-dihydro-3H-indolen, 5-Hydroxy-1,2-dihydro-3H-pyrrolo[3,2-e]indolen und 5-Hydroxy-1,2-dihydro-1H-benzo[e]indolen sowie von 6-Hydroxy-1,2,3,4-tetrahydro-benzo[f]-chinolinen entwickelt, die im Rahmen der ADEP-Therapie (antibody directed enzyme prodrug therapy) eingesetzt werden können. Die neuen Prodrugs zeichnen sich durch einen hohen Toxizitätsunterschied zwischen Prodrug und zugrundeliegendem Drug und einer sehr hohen Wirksamkeit des Drugs aus. Die hohe Selektivität der neuen Prodrugs ist vermutlich darauf zurückzuführen, dass in den neuen Prodrugs im Gegensatz zu den von uns früher hergestellten Prodrugs ähnlichen Typs ein sekundäres Halogenid vorliegt. Dadurch wird die direkte Alkylierung der DNA oder RNA durch die Prodrugs und damit die Toxizität der Prodrugs herabgesetzt. Nach Abspaltung der glykosidischen bzw. acetalischen Gruppe an der phenolischen Hydroxygruppe der Prodrugs erfolgt die Bildung eines Spirocyclopropacyclohexadiens, das als hochtoxische Gruppe eine Alkylierung der DNA bzw. RNA bewirkt.
Patent WO-0207691-A2 (WO)
Title: Composition dentaire
Inventor: GUAN YUE HUGH
IPC: A61K8/90
Filed: 2001-07-25
Abstract: Compositions servant à inhiber l'adhérence et la formation de plaques et/ou de taches sur la dentition, lesdites compositions contenant deux poloxamères sélectionnés dans un premier groupe de poloxamères dont le point de fusion est situé dans une plage de 48 à 58 °C et la valeur HLB dans une plage de 22 à 29 et un deuxième groupe de poloxamères dont le point de fusion est situé dans une plage de 27 à 35 °C et la valeur HLB dans une plage de 8 à 17, lesdits poloxamères étant sélectionnés dans le même groupe ou dans des groupes différents.
Patent WO-0217117-A2 (WO)
Title: Procedes et appareil de mise en signets electronique d'emplacements de vendeur par le biais d'un assistant numerique personnel ou d'un autre dispositif d'utilisateur
Inventor: TROVATO KAREN I
IPC: H04W4/06
Filed: 2001-08-13
Abstract: Un assistant numérique personnel, un téléphone sans fil, un ordinateur portable ou un autre dispositif obtient et stocke une identification de vendeur associée à un emplacement physique spécifique de vendeur, emplacement désigné comme présentant un intérêt pour un utilisateur du dispositif. Par exemple, le dispositif d'utilisateur peut obtenir l'identification du vendeur par le biais d'une liaison de télécommunication sans fil établie avec un système au niveau de l'emplacement physique du vendeur, en réponse à une entrée d'une commande de signet par l'utilisateur. L'identification stockée du vendeur sert de signet à l'emplacement correspondant de vendeur, et est utilisée par la suite par le dispositif d'utilisateur pour extraire ou obtenir une information de vendeur mise à jour périodiquement et concernant l'emplacement spécifique du vendeur, de telle manière que la dernière information ayant trait à l'emplacement du vendeur marqué en signet est disponible à l'utilisateur par le biais du dispositif de l'utilisateur.
Patent WO-02060559-A2 (WO)
Title: Masse de filtration dans un filtre pour fluides, comportant une structure a couches
Inventor: BARACCHI PAOLO
IPC: B01D39/18
Filed: 2002-01-22
Abstract: Masse de filtration pour filtres pour fluides, qui comporte au moins une couche (1) constituée de papier conçue pour être la première couche traversée par un fluide afin de provoquer une filtration grossière, et une seconde couche (2) constituée de fibre de verre qui est appropriée pour provoquer une filtration fine. La masse de filtration comporte en outre au moins une couche (4, 5) de tissu non tissé qui est en contact avec la surface de la couche (2) constituée de fibre de verre orientée vers l'évacuation du fluide.
Patent WO-03063264-A2 (WO)
Inventor: STROEBEL RAIMUND
IPC: H01M8/247
Filed: 2003-01-22
Abstract: La présente invention concerne une plaque bipolaire (1) et un ensemble (2) de cellules électrochimiques. Ladite plaque bipolaire possède deux faces externes (3a, 3b) électriquement connectées en vue de la mise en contact électrique ainsi que des orifices d'amenée de gaz et / ou de liquides vers des surfaces de cellules électrochimiques voisines des faces externes, et d'évacuation de gaz et / ou de liquide desdites surfaces. La plaque bipolaire possède un cadre ouvert (7) dans sa zone centrale ainsi qu'une partie interne (3) placée dans la zone centrale, le cadre et la partie interne étant raccordés l'un à l'autre de manière élastique.
Patent WO-03100070-A2 (WO)
Title: Frog prince, un vecteur de transposons destine a transferer des genes dans des vertebres
Inventor: MISKEY CSABA
IPC: A61K48/00
Filed: 2003-05-30
Abstract: L'invention concerne un système d'intégration d'ADN basé sur des transposons comprenant (1) un transposon dépourvu d'un polynucléotide codant une transposase fonctionnelle et comprenant un polynucléotide d'intérêt, le transposon comprenant des séquences répétitives inversées qui possèdent un degré d'identité, respectivement, avec les séquences répétitives se trouvant dans la SEQ ID NO: 2 et sa séquence répétitive inversée, d'au moins 90 %; et (b) une transposase possédant au niveau de son N-terminal, un domaine de liaison d'ADN comprenant les séquences de SEQ ID NO: 3 et 4; ou (c) un polynucléotide codant la transposase de (b). L'invention concerne, en outre, un procédé de transfert d'un polynucléotide d'intérêt dans des cellules d'un vertébré consistant à introduire le système d'intégration d'ADN basé sur des transposons de l'invention dans ces cellules. En outre, elle concerne un procédé d'action sur l'ARNi consistant (a) à introduire de façon stable un transposon comprenant une cassette d'expression exprimant une ARN d'interférence courte et un gène marqueur sélectionnable en tant que partie du système d'intégration d'ADN basé sur des transposons de l'invention dans une cellule; (b) à sélectionner des cellules exprimant le marqueur sélectionnable et (c) à déterminer si la transcription/translation du gène désiré est effectuée par l'ARNi ou non. Un autre mode de réalisation de l'invention consiste en un procédé de piégeage de gène consistant (a) à introduire le système d'intégration d'ADN basé sur des transposons de l'invention dans une cellule; et (b) à évaluer l'expression d'un marqueur sélectionnable dont l'expression est indicative de l'intégration du transposon dans un gène transcrit de la cellule.
Patent WO-2004021895-A2 (WO)
Title: Chirurgische vorrichtung zum durchtrennen von knochengewebe
Inventor: HAEUSLER RAINER
IPC: A61B17/64
Filed: 2003-08-08
Abstract: Um bei einer chirurgischen Vorrichtung zum Durchtrennen von Knochengewebe (60) mittels eines gegebenenfalls Abrasivpartikel enthaltenden Flüssigkeitsstrahles (63) mit einer Hochdruckquelle zur Erzeugung des Flüssigkeitsstrahles (63) und mit einer den Flüssigkeitsstrahl (63) gegen das zu durchtrennende Knochengewebe (60) richtenden Strahleinrichtung (29) einen Schutz vor unerwünschten Einwirkungen des Flüssigkeitsstrahles (63) zu erreichen,wird vorgeschlagen, dass die Vorrichtung ein geschlossenes, das zu durchtrennende Knochengewebe (60) allseits umgebendes Gehäuse (22) umfasst,welches einen abgedichteten Zugang (24) für die Strahleinrichtung (29) sowie eine Sammeleinrichtung (7) für die von der Strahleinrichtung (29) gegen das Knochengewebe (60) gerichtete Flüssigkeit aufweist.
Patent WO-2004040961-A2 (WO)
Title: Apparatus and method for mounting a device for displaying and preserving flower arrangements
Inventor: CHARRIN PHILIPPE
IPC: A01G5/02
Filed: 2003-11-04
Abstract: The invention concerns an apparatus for mounting a device (10) for displaying individual flower arrangements, said device comprising a base element (2) provided or not with a raised edge (4) over its entire circumference, and a sheet (5) sealing or not placed beneath the base element (2) converging towards the central summit of the device (10) and maintained by a fixing element (9) formed by a ribbon (7) for maintaining the sheet sealed (5) around the flower arrangement. The invention is characterized in that the apparatus comprises: a plurality of mobile pivoting draping fingers (15) associated with a binding cord (16) for guiding the sheet (5) around the base element (2), a support base plate (20) mobile along a vertical axis to support the device (10), guide means (21) of predetermined shape linked to the base plate (20) for guiding the plurality of draping fingers (15), and actuating means (30) for moving the support base plate (20) and the guide means (21) along the vertical axis and for pivoting the plurality of draping fingers (15) being guided by the guide means (21) so as to bind the cord (16) around the draped sheet (5).
Patent WO-9728884-A2 (WO)
Title: Compounds for the sorption of gases
Inventor: MATACOTTA FRANCESCO CINO
IPC: C01G3/00
Filed: 1997-02-10
Abstract: Compounds having the formula: A2B3O6±d wherein A is an alkaline-earth metal, an alkaline metal, a lanthanide, or a solid solution thereof, B is a transition metal, an element of group III, or a solid solution thereof, and d has a value between 0 and 1; a method for preparing the compounds; a method for producing composite materials on various matrices and thin or thick films deposited on various substrates which contain the compounds; their use; and a method for eliminating certain gases from a mixture that includes them by using the compounds.
Patent WO-9837124-A2 (WO)
Title: Verfahren zur herstellung von aromatischen polyamingemischen
Inventor: BECKER RAINER
IPC: C07C209/78
Filed: 1998-02-20
Abstract: In einem Verfahren zur Herstellung von aromatischen Polyamingemischen, die Verbindungen der allgemeinen Formel (I) enthalten, H2N-A-CH2-B-NH2, in der A und B 1,4-Phenylenreste sind, die jeweils unabhängig 1 bis 4 Substituenten, ausgewählt aus C1-20-Alkylresten und Halogenatomen, aufweisen können, werden eine Verbindung der allgemeinen Formel (IV), H-A-NH-CH2-HN-B-H und/oder eine Verbindung der allgemeinen Formel (V), H-A-NH-CH2-B-NH2, wobei A und B wie vorstehend substituiert sind, bei einer Temperatur im Bereich von 20 °C bis 200 °C in Gegenwart eines Katalysators aus einem oder mehreren Oxiden von Elementen der 3. bis 10. Gruppe des Periodensystems der Elemente, der säureaktiviert sein kann, umgesetzt.
Patent WO-9851048-A2 (WO)
Inventor: O'NEILL RORIE JULIAN TURNBULL
IPC: H04B7/08
Filed: 1998-04-22
Abstract: In response to an uplink transmission from a mobile unit (112) of a composite signal envelope (68) comprised from multiple sub-channels (10-16) of modulated data, a plurality of spatially separated antennas (118-120) of a base station (116) each receive the composite signal envelope (68) via different propagation paths (122-124). A decoder (72) decodes composite signal envelopes (68) received at the plurality of antennas and then a controller (46) assesses quality metrics for the multiple sub-channels of the composite signal envelopes received at the plurality of antennas. The controller (46) in the base station (116) then optimises retrieval of information transmitted on the uplink by selecting sub-channels (10-16), based on the quality metrics, obtained from composite signal envelopes received at the plurality of antennas via the different propagation paths (122-124), as detailed in Fig. 6.
Patent WO-0048355-A2 (WO)
Title: Method for verifying the use of public keys generated by an on-board system
Inventor: PINKAS DENIS
IPC: G09C1/00
Filed: 2000-02-10
Abstract: The invention concerns an on-board system for verifying a certification request of a public key (Kp) generated by an on-board identifier system (SNi). For an assembly (Lk) of on-board systems, an authorised identifier (OPj) operator configures the on-board systems and generates (1001) a parent public key (KpM) and a parent private key (KsM). The identifier (Opj), the reference range of identifiers (Lk) and the public key (KpM) are issued (1002). For each on-board system (SNi), a diversified key (KsMi) is generated from the identifier (SNi) and stored (1003) in a storage unit with protected reading and writing access. For every public key (Kp) generated by an on-board system, a cryptographic control value (Sci) is computed (1006) on the public key (Kp), an algorithm identifier (CA1) and utilisation parameters (U) of said key using a zero-knowledge signature algorithm and a certification request message (MRCA) including the control value (Sci), the operator identifier (Opj) and the identifier (SNi) is transmitted to a certification authority, which retrieves the identifier (Opj) (1009) and the parent public key (KpM) value (1001). Verification (1012) of the message (MRCA) from the parent public key (KpM) and of the identifier of the on-board system (SNi) enables to ensure that the public key (Kp) certification request and the use thereof originates indeed from an on-board component capable of restricting the use of said key.
Patent WO-02067016-A2 (WO)
Inventor: ARTONNE JEAN-CLAUDE
IPC: G03B17/56
Filed: 2002-02-13
Abstract: L"invention concerne un dispositif (20, 21) support d"appareil photographique comprenant des moyens (23, 12) de fixation d"un appareil photographique (10) équipé ou pouvant être équipé d"un premier objectif (11), et des moyens (3A, 3B) de rotation autour d"un axe, caractérisé en ce qu"il comprend des moyens de fixation d"un objectif adaptateur (15), notamment un objectif adaptateur panoramique, agencés pour maintenir l"objectif adaptateur (15) dans l"alignement du premier objectif (11) sans qu"il soit nécessaire de fixer l"objectif adaptateur à l"appareil photographique.
Patent WO-02102344-A2 (WO)
Title: No-synthase inhibitor and use thereof
Inventor: CALS-GRIERSON MARIE-MADELEINE
IPC: A61P25/00
Filed: 2002-06-14
Abstract: The invention relates to the use of an effective amount of N,N'-bis-pyridyl-2-yl-methyl-N,N'-bis-(3,4,5-trimethoxybenzyl) ethylenediamine in a physiologically acceptable medium in a composition or for the production of a composition, said N,N'-bis-pyridyl-2-yl-methyl-N,N'-bis-(3,4,5-trimethoxybenzyl) ethylenediamine, or the composition for NO-synthase inhibition.
Patent WO-03064769-A2 (WO)
Inventor: COGUELIN MICHEL
IPC: D21H27/00
Filed: 2003-01-29
Abstract: La présente invention concerne une feuille impression-écriture comprenant un support dont au moins une face présente une surface apte à recevoir au moins un type d'inscriptions effaçables à sec, ladite surface étant formée par une composition comportant un agent filmogène et un agent anti-adhérent et exempte de pigments de couchage. Elle concerne aussi un article réutilisable comprenant au moins ladite feuille.
Patent WO-2004000509-A2 (WO)
Title: Telescopic arm
Inventor: GARREC PHILIPPE
IPC: B25J18/02
Filed: 2003-06-24
Abstract: The invention relates to a telescopic arm. According to the invention, polygonal-section segments (1) of a telescopic robot arm or another telescopic structure are made from open sections (11) and assembled by means of the overlapping edges (12) thereof with the aid of screws (13) which can be used to adjust the assembly of same and to reduce the effects of natural hyperstaticity of the arm, which are produced by a large number of rail and slide connections between segments. In this way, it is possible to produce stiff arms which are not excessively heavy.
Patent FR-2265416-A2 (FR)
Title: Suppository applicator - simple and hygienic to use
IPC: A61M31/00
Filed: 1974-03-26
Abstract: A suppository application consists of a main tube in which slides a tube fitted with a piston-pusher, and over which is put a guide tube. The suppository is placed in the guide tube, which passes the anal sphincter. It has a shoulder limiting penetration. The piston pusher tube can accept pieces of different sizes and the main tube can accept guides of different sizes. The applicator is for use partic. in hospitals, clinics, day-nurseries, lying-in hospitals and in private homes. The appts. is easier to use and more hygienic than existing appts. Only the guide tube is in contact with the mucous membrane, making cleaning easy.
Patent FR-2276962-A2 (FR)
Title: Vehicle safety belt damper - has pull rod with return motion stop system to prevent occupant rebound
IPC: B60R22/28
Filed: 1974-07-03
Abstract: Safety belt damper exerts a progressive tension on the belt and damps the impact on the wearer, with units which suppress the rebound rearward of the occupant. Part of the damper is attached with one end to the vehicle body, and the other end is attached to the belt. A pull rod which can be displaced against the action of a compression spring has a return motion stop system. Preferably the rod is a rack and the damper has notches on one side for engagement of a spring-loaded locking pawl. A pinion engages the rack and can be actuated by a crank which can return the damper in to its working position after the pawl is released from the rod.
Patent FR-2270329-A2 (FR)
Title: Annealing drawn wire travelling at very high speeds - by resistance heating using constant torque motors on contact rollers
IPC: C21D9/62
Filed: 1975-05-07
Abstract: The parent specification described a device for electric heat-treatment of bare wire passing over several contact rollers and insulated guide rollers, where at least the surfaces of the contact rollers touching the wire are made of, or coated with an electrically-conducting material with a m. pt. over 1200 degrees C. In this specification, at least one of the rollers is coupled to a motor which in one speed range delivers a constant torque independent of its rotational speed. A compressed-air motor is pref. used. The device is useful for high-speed annealing of drawn Cu or Al wire, e.g. 0.5 mm Al wire travelling at speeds at 1000-2000 m/min. The modification prevents high tensile strength arising in the wire due to the very high speed, and also prevents wear of the rolls.
Patent FR-2321103-A2 (FR)
Title: Constant temp. cylinders for e.g. calenders in textile or paper mfr. - using easily volatised oil condensing on outer cylinder
Inventor: JOHNSON JACK
IPC: D21G1/02
Filed: 1975-08-14
Abstract: The constant temp. is maintained by partially filling the annular space between the periphery of the cylinder and a second concentric inner cylinder with an easily volatilised oil, (b) pumping out of the annular space to a predetermined press. at atmospheric temp. and subsequent sealing of this space, (c) evaporating the easily volatilised oil at a temp. determined by the pressure in the annular space using a heating medium which is present between the wall of the second cylinder and a third inner most concentric cylinder. The constant temp. maintained on the outside of the cylinder can be predetermined by the press. above the oil in the annular interspace rather than by the supply of heat.
Patent FR-2362650-A2 (FR)
Title: Distillation column having several sections - in which condensate flows from one section to another down a wall to slow up flow rate
Inventor: HANCOCK ALLEN WOODROW II
IPC: C07B31/00
Filed: 1977-04-15
Abstract: Column has several sections arranged one above the other, each section including a platform with an overflow lip arranged above a reservoir. A cylinder through which vapour passes is mounted in each reservoir to preduce condensate which passes through an over-flow tube from the reservoir of one section onto the platform of the section below. In the improvement the over-flow lip has an extension wall extending into the reservoir. Condensate passing over the overflow lip runs down the extension wall into the reservoir. The flow rate of condensate from one section to the other in reduced, thereby improving the efficiency of the distn. process.
Patent FR-2395891-A2 (FR)
Title: Heavy aircraft transporter for ground manoeuvring - has aircraft wheel support platform with clamps reached by tail ramp
Inventor: BOYER JEAN-JACQUES
IPC: B60P3/11
Filed: 1977-07-01
Abstract: The transporter is fitted with a tail ramp (7) which can be lowered onto the ground at the rear end. The ramp is fitted with friction pads (9) to prevent the aircraft wheels from slipping. The ramp is lowered by means of a lever (23) operated by a hydraulic ram (21). The aircraft wheels travel off the ramp onto the platform (4) which is circular and able to rotate about a central vertical axis. The centre of the platform is recessed and the aircraft wheels are clamped on the platform. The platform is fitted with a ball race to ensure its rotation.
Patent FR-2449561-A2 (FR)
Inventor: FLUSIN FRANCOIS
IPC: B60R19/34
Filed: 1979-02-23
Abstract: This kinetic energy absorber device relates mainly to the absorption of high energy shocks which result from the collision of obstacles by all kinds of moving bodies of vehicles. This device is comprised of an undeformable male penetrator (29) and a ductile metal receiver female part (27). One of these two members is integral with the moving body whereas the other one is subjected to the action of the obstacle which is opposed to the motion of the moving body. Under the shock effect, the penetrator is engaged into the female part that is deformed plastically. It is this plastic deformation work which absorbs the major part of the kinetic energy. The female part is made preferably of austenitic steel with unstable austenite. This device allows particularly the absorption of violent shocks by motor vehicles.
Patent FR-2461709-A2 (FR)
Title: 2,3-Di:hydro-2,2-di:methyl-7-hydroxy-benzofuran prepn. - by heating ortho-methallyl-pyrocatechol or ortho methallyl-oxy-phenol with water and opt. organic solvent
Inventor: MICHELET DANIEL
IPC: C07D307/86
Filed: 1979-07-18
Abstract: Prepn. of 2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofuran (I) comprises heating orthomethallylpyrocatechol (II) or orthomethallyloxy-phenol (III) in the presence of water and opt. an organic solvent. (I) is used to prepare 2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate (carbofuran), a known insecticide.
Patent FR-2469097-A2 (FR)
Title: Vine pre-pruning cutter - has rocking arm axis at central part of knife shaft zone of movement
Inventor: SENEGAS CHRISTIAN
IPC: A01G3/04
Filed: 1979-11-07
Abstract: The vine pre-pruning cutter has the axis of the rocking arm (10) positioned on the horizontal beam (2) at the central part of the horizontal zone through which the knife shaft (12), mounted on the arm, swings. The shaft can be mounted on a bracket (34) pivoting on the end of one or more rocking arms, to form a parallelogram linkage, whose movement towards the outside of the machine can be limited by an adjustable stop (36), while there is an elastic stop (37) limiting movement in the inwards direction.
Patent FR-2474720-A2 (FR)
Title: Electronic display for periodic function - uses stored line segments joining successive points to provide beam modulation signal
Inventor: HOLDING DEREK
IPC: G01R13/34
Filed: 1980-01-28
Abstract: The display has a function curve built-up from individual line segments of varying lengths. A memory (M) stores each segment joining two points on the curve representing two successive values, the scanning beam modulated via a circuit comprising a D/A converter (DAC), a sample and hold circuit (E), two comparators (C1,C2) and a points generator (P). One of the inputs of each comparator (C1,C2) receives the output of a sawtooth generator (G) controlled by the line return pulses. The other inputs of the comparator respectively receive the input and output signal of the sample and hold circuit (E). The outputs of the comparators go to the modulation mixer (M) via a logic combining circuit and via the points generator (P). The mixer output is used as the modulation signal. The display allows a continuous representation of a curve defined by discrete points.