baber/WOPTO huggingface dataset:
Patent CA-2559281-A1 (CA)
Inventor: PATEL MANISH
IPC: C07H17/00
Filed: 2005-04-25
Abstract: The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts Formula I The novel compounds (i) 10,11-Anhydro-2',4''-di-O-benzoyl-12-O-imidazolylcarbonyl-6-O-methylerythromycin A of formula (Xa) Formula (Xa) (ii) 2',4''-di-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O-methylerythromycin A 11,12-cyclic carbamate of formula (XIa) Formula (XIa) (iii) 2'-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O-desosaminyl-6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) Formula (XIIa) (iv) 2'-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O-desosaminyl-6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) Formula (XIIa) and their use as intermediates in formation of compound of Formula I. Also the process of preparation of compound of formula (XIIIa). Formula (XIIIa)
Patent CA-2561630-A1 (CA)
Inventor: AWADALLA SALAH
IPC: G01T1/24
Filed: 2006-09-29
Abstract: A semiconductor radiation detector is provided for improved performance of pixels at the outer region of the crystal tile. The detector includes a semiconductor single crystal substrate with two major planar opposing surfaces separated by a substrate thickness. A cathode electrode covers one of the major surfaces extending around the sides of the substrate a fraction of the substrate thickness and insulated on the side portions by an insulating encapsulant. An exemplary example is given using Cadmium Zinc Telluride semiconductor, gold electrodes, and Humiseal encapsulant, with the side portions of the cathode extending approximately 40-60 percent of the substrate thickness. The example with CZT allows use of monolithic CZT  detectors in X-ray and Gamma-ray applications at high bias voltage. The shielding electrode design is demonstrated to significantly improve gamma radiation detection of outer pixels of the array, including energy resolution and photopeak counting efficiency. The detector has performance of detector leakage current density less than 6 nA/mm2 at a bias potential of substantially 1400V, and responsive to gamma radiation such that the energy resolution full width half maximum of more than 90% of the pixels is less than 6%.
Patent CA-2562610-A1 (CA)
Title: Handheld electronic communication device with metallic keypad
Inventor: ROBERT LYDIE
IPC: H01H13/70
Filed: 2006-10-05
Abstract: The present invention relates to a handheld electronic communication device comprising, in a housing (1), a printed circuit board (2) for holding electrical components and providing several connection points, and a keypad (5) extending parallel to said printed circuit board (2) and including a keypad user's interface (5c), made of a metallic sheet, said device further comprising a radio communication module for transmitting and/or receiving signals, said radio communication module being connected to a radiating element via an antenna's feeding point on printed circuit board (2), According to the invention, said metallic sheet is provided with at least a connection area (5e) electrically connected to said antenna's feeding point of said printed circuit board (2), and said metallic sheet further comprises a slot (8), said keypad user's interface (5c) constituting then said radiating element whose working frequencies depend on the shape and the size of said slot.
Patent CA-2563569-A1 (CA)
Title: Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor
Inventor: LAKE PHILIP
IPC: A61P37/06
Filed: 2005-05-02
Abstract: The invention provides a pharmaceutical combination comprising: a) at least one S1P receptor agonist, and b) at least one JAK3 kinase inhibitor and a method for treating or preventing autoimmune diseases or cell, tissue or organ graft rejection using such a combination.
Patent CA-2564355-A1 (CA)
Title: Protein kinase modulators and method of use
Inventor: TEMPEST PAUL A
IPC: C07D407/14
Filed: 2005-05-09
Abstract: The present invention relates to chemical compounds having a general formula (I) wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
Patent CA-2565046-A1 (CA)
Title: Perfluorinated esters, polyester, ethers and carbonates
Inventor: LAZZARI DARIO
IPC: C14C9/00
Filed: 2005-05-18
Abstract: The present instant invention relates to new compounds of the formula (I) wherein T is H or R; R is R1, -CO-R2, -CO-R3-COOH, -COO-R4 or R5; R1 is independently Formula (II) or Formula (III); and to compositions comprising these novel compounds and natural, synthetic or semisynthetic material. Such compounds are useful as water and/or oil repellents.
Patent CA-2565403-A1 (CA)
Inventor: ZHOU MING
IPC: G01N21/76
Filed: 2006-10-24
Abstract: An electrochemiluminescent chip for chemo- and bio-analytical applications has a nanostructured surface defining electrically conducting regions serving as an electrochemical electrode and chemo- or bio- functionalized regions for immobilizing analyte-specific electroluminescent recognition species. The chip is suitable for incorporation into a handheld device.
Patent CA-2565598-A1 (CA)
Title: Incentive based health care insurance program
Inventor: HODGDON DARREN
IPC: G06F19/00
Filed: 2005-03-29
Abstract: Apparatuses, systems, programs, and/or methods of administering an incentive health care insurance program are provided. In one aspect, the apparatuses, systems, programs, and/or methods comprise offering one or more incentives to a participant of a health care insurance program to complete a health risk assessment questionnaire or a biometric measurement analysis, and/or to provide a biosample for biomedical analysis; scoring, ranking, and/or grading the health risk assessment and/or the biometric parameters for one or more health risks; analyzing the biosample for one or more biomedical parameters;  analyzing the scored, ranked, and/or graded health risk assessment questionnaire and/or the biometric parameters, and/or biomedical parameters and determining a Health Score to assess for presence or risk of disease; and optionally providing one or more additional incentives to the one or more participants to achieve, maintain, or improve their Health Score and/or an individual parameter of a Health Score.
Patent CA-2565967-A1 (CA)
Title: Multiplexing assays for analyte detection
Inventor: DICESARE JOSEPH L
IPC: G01N33/543
Filed: 2005-06-10
Abstract: High density multiplexing assays for proteins, nucleic acids, and other molecules are described based upon using mass spectrometry detection. A solid-state support assay format is utilized, whereby, the bead carries both a coding molecule to track the sample or analyte and the molecule(s) necessary to perform an affinity-based assay. After the necessary reactions are complete, all of the components, e.g., coding molecule, binding molecule, analyte, and/or label are dissociated for analysis in a mass spectrometer.  Various means of performing detection for the assays include different types of mass spectrometers with different types of sampling systems, including MALDI-TOF and ESI.
Patent CA-2567738-A1 (CA)
Title: The use of cardiac hormones for diagnosing the risk of suffering from a cardiovascular complication as a consequence of cardiotoxic medication
Inventor: HORSCH ANDREA
IPC: G01N33/74
Filed: 2005-06-14
Abstract: The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of cardiotoxic medication, in particular chemotherapeutics, including anthracyclines. In particular, the invention relates to a method for diagnosing the risk of a patient who is going to receive cardiotoxic medication of suffering from a cardiovascular complication as a consequence of the cardiotoxic medication, comprising the steps of (a) taking a body fluid or tissue sample, and (b) measuring, preferably in vitro, the level of a cardiac hormone. Preferred cardiac hormones in the context of the present invention are ANP, NT-proANP, BNP, and NT-proBNP.
Patent CA-2568714-A1 (CA)
Title: A biomolecule-containing formulation of increased stability
Inventor: LIU KUI
IPC: A61K31/7024
Filed: 2005-05-23
Abstract: A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
Patent CA-2572119-A1 (CA)
Title: Combination therapies utilizing benzamide inhibitors of the p2x7 receptor
Inventor: GABEL CHRISTOPHER A
IPC: A61P17/06
Filed: 2005-06-16
Abstract: This invention provides methods of treatment of IL-1 mediated diseases comprising administering a pharmaceutically effective amount of a pharmaceutical agent selected from the group of sulfasalazine, a statin, a glucocorticoid agent, an inhibitor of p38 kinase, an anti-IL-6-receptor antibody, anakinra, an IL-1 monoclonal antibody, an inhibitor of JAK3 protein tyrosine kinase, a M-CSF monoclonal antibody or a humanized anti-CD20 monoclonal antibody and a benzamide inhibitor of the P2X7 receptor of the formula (I): wherein R1-R3 are as defined herein. The methods of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
Patent CA-2575582-A1 (CA)
Inventor: GREGORY MATTHEW ALAN
IPC: C07D273/00
Filed: 2005-08-11
Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds.  Therefore in. one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods_ for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17~desinethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections,. transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.
Patent CA-2577119-A1 (CA)
Inventor: LIM MU-ILL
IPC: A61K8/00
Filed: 2005-08-26
Abstract: Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivatives thereof. A method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.
Patent CA-2578790-A1 (CA)
Title: Regeneration de tissu vaginal par le biais de l'administration non systemique d'oestrogene dans le vagin
Inventor: LYLE JOHN W
IPC: A61P15/02
Filed: 2006-01-20
Abstract: Méthodes et formules pour régénérer un tissu vaginal et la santé de cellules vaginales suite à une hypoxie cellulaire vaginale chez une femme. Une composition pharmaceutique pour administration locale non systémique contient un agent hormonal administré sur le vagin, sur la région vulvaire d'une personne recevant ledit traitement.
Patent CA-2581763-A1 (CA)
Title: Self-fixating implantable scaffolds for the administration of biological or pharmaceutical substances
Inventor: SIGG DANIEL C
IPC: A61N1/30
Filed: 2005-10-13
Abstract: A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.
Patent CA-2582047-A1 (CA)
Title: Device and method for representing the direction of action of a working means
Inventor: SATZGER WILHELM
IPC: B23Q17/22
Filed: 2005-10-07
Abstract: The invention relates to a device for representing the direction of action (9) of a working means (3), in particular a tool or a radiation source and/or a radiation emitter, for example, of X-rays. Said device comprises a first light source (4) which is used to produce a first beam (5). In order represent the direction of action in a continuous manner, at least one additional light source (4') which is used to produce an additional beam (5') is provided. The light sources (4, 4') and the working means (3) can be oriented in such a manner that the first beam (5) and the additional beam (5') have a flat extension and cut in the direction of action (9) of the working means (3). The invention also relates to a corresponding method.
Patent CA-2583021-A1 (CA)
Inventor: PIURI PAOLO
IPC: H05B3/02
Filed: 2007-03-21
Abstract: It is hereby described an electric radiator (1) comprising an electrically heating plate (3),characterized in that said electrically heating plate (3) has a layer of ferromagnetic material (32).
Patent CA-2587348-A1 (CA)
Title: Organic compounds
Inventor: GROSCHE PHILIPP
IPC: C07D413/04
Filed: 2005-12-28
Abstract: 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin;  the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4~substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.
Patent CA-2588540-A1 (CA)
Title: Method to condense and recover carbon dioxide (co2) from co2 containing gas streams
Inventor: LOURENCO JOSE
IPC: F25J3/06
Filed: 2007-05-09
Abstract: A method to condense and recover CO2 from CO2 containing streams. A first step involve providing at more than one heat exchanger, with each heat exchanger having a first flow path for passage of a first fluid and a second flow path for passage of a second fluid. A second step involves passing a stream of very cold natural gas sequentially along the second flow path of each heat exchanger until it is heated for distribution and concurrently passing a CO2 containing stream sequentially along the first flow path of each heat exchanger, allowing the water vapor portion of the CO2 containing stream to condense and precipitate on the condensing heat exchangers. A third step involves passing a water vapor free CO2 containing stream to a cryogenic heat exchanger to condense, precipitate and recover CO2. This processes results in the recovery of CO2 and water vapor from CO2 containing streams using condensing heat exchangers, chiller, compressor, expander and power generator to recover the low value thermal heat available in CO2 containing waste streams.
Patent CA-2589274-A1 (CA)
Title: Inhibitors of protein kinases
Inventor: MOORE WILLIAM R JR
IPC: C07D411/02
Filed: 2005-12-07
Abstract: The present invention is directed to a compound having the formula (I) wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.
Patent CA-2589845-A1 (CA)
Title: Display panel mounting system and method
Inventor: HARRIS ROD
IPC: G09F7/18
Filed: 2007-05-23
Abstract: A display mounting kit, system, and method are disclosed utilizing first an d second primary releasable attachment elements that are secured about the periphery of a display panel and in a substantially corresponding relationsh ip on a mounting surface, respectively. At least one supplementary fastening element having a stiff core and first and second substantially planar surfaces for respective engagement with the display panel and the mounting surface provides secure mounting between the display panel and the mounting surface.
Patent CA-2589858-A1 (CA)
Inventor: SCHNEIDER MICHAEL
IPC: G01S13/75
Filed: 2005-12-02
Abstract: A system for tracking items includes a turntable to receive a pallet containing articles having RFID devices, a transceiver disposed adjacent to the turntable to transmit and receive a signal from the RFID devices, and a wrap dispenser to wrap the articles with wrap as the turntable rotates. A  method is provided including loading articles having RFID devices thereon on a pallet, loading the pallet on a turntable, attaching an end of a wrap to at least one of the articles, rotating the turntable to cause the wrap to encircle the articles until all of the articles are constrained in position by the wrap, transmitting a signal to the RFID devices to cause the each RFID  device to emit a signal back to the transceiver, and reading the signals from the RFID devices to obtain information contained in the signals.
Patent CA-2592217-A1 (CA)
Inventor: RIES ERIC NATHAN
IPC: G06T15/70
Filed: 2006-01-11
Abstract: L'invention concerne un modèle hiérarchique de revenus mis en oeuvre par ordinateur, destiné à gérer les attributions de revenus entre des producteurs de produits dérivés dans un système en réseau. Le modèle comporte les étapes consistant à: fournir une première valeur de revenu associée à un premier composant numérique; fournir une deuxième valeur de revenu associée à un deuxième composant numérique; et combiner la première valeur de revenu à la deuxième afin de produire une troisième valeur de revenu, associée au deuxième composant numérique, le deuxième composant numérique comprenant au moins une partie du premier composant numérique.
Patent CA-2593211-A1 (CA)
Title: Spread spectrum signal
Inventor: RIES LIONEL
IPC: H04B1/707
Filed: 2006-01-12
Abstract: A spread-spectrum signal comprises a spreading waveform modulating a carrier wave and containing a real linear combination of a first waveform at a first waveform rate and a second waveform at a second waveform rate, the first waveform rate being distinct from the second waveform rate and both waveform rates being distinct and non-zero. The linear combination of the first and the second waveform is modulated with at least one binary sequence comprising a signal identification code.
Patent CA-2593727-A1 (CA)
Title: Drive for a vehicle, especially a tracked vehicle or a vehicle with wheel-based steering
Inventor: DOBEREINER ROLF
IPC: B60L50/10
Filed: 2007-06-26
Abstract: A drive for a vehicle, especially a tracked vehicle or a vehicle with wheel-based steering, with at least one component which consumes electric energy and at least one power electronic component (power electronics) for providing the necessary electric energy, where the power electronics can be cooled with a fluid by the evaporative cooling process.
Patent CA-2594494-A1 (CA)
Title: Process to chiral beta amino acid derivatives by asymmetric hydrogenation
Inventor: SUN YONGKUI
IPC: C07C227/32
Filed: 2006-01-20
Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of an ammonium salt and a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
Patent CA-2594541-A1 (CA)
Inventor: REUZEAU CHRISTOPHE
IPC: C07K14/415
Filed: 2005-12-23
Abstract: The present invention concerns a method for increasing plant yield in plants grown under non-stress conditions, by preferentially increasing activity in a plastid of an EFTu polypeptide or a homologue thereof. One such method comprises introducing into a plant an EFTu nucleic acid or variant thereof.  The invention also relates to transgenic plants having introduced therein an EFTu nucleic acid or variant thereof, which plants have increased yield, particularly increased seed yield, relative to corresponding wild type plants.  The present invention also concerns constructs useful in the methods of the invention.
Patent CA-2600493-A1 (CA)
Inventor: DYERS RICHARD J
IPC: C09K23/00
Filed: 2006-03-16
Abstract: A method for cleaning oil wells to increase the flow of oil thereof by use of a unique aqueous cleaning emulsion comprising of water, hydrocarbon solvent, detergent and mineral acid. This one step method provides for the simultaneously cleaning/removal of asphaltine and/or paraffin and scale. This method can be used alone or with the assistance of a wash tool which is a combination pressure and surge wash tool having a nipple assembly. A by-pass port is coupled to the nipple assembly and a diverter cup is coupled to the by-pass port. A plurality of pressure wash cups are positioned on the tool. A  pressure wash port is located between the plurality of pressure wash cups and a pump shoe assembly is coupled to a bottom pressure wash cup.
Patent CA-2601097-A1 (CA)
Title: Danger warning system and method for determining configuration of danger warning system
Inventor: KAESTLI URS
IPC: G08B26/00
Filed: 2006-03-09
Abstract: The invention relates to a danger warning system comprising a central station (Z) and appliances (Mn) which are connected thereto by means of a monitoring line (ML). Each appliance (Mn) comprises an insulator switch (S), an unequivocal identification number, and a communication address. In order to determine the configuration of the danger warning system, the appliances (Mn) that can be decoupled by means of the insulator switch (S) are sequentially started and announced to the central station (Z). In the event of simultaneous announcements of more than one appliance (Mn), only the announcement of one of said appliances (Mn) is accepted. During the announcement of appliances (Mn) at the central station (Z) with the communication addresses thereof, when appliances (Mn) with different communication addresses are simultaneous announced, the communication addresses are differed according to an arbitration method, and the two different communication addresses are sequentially registered. When appliances (Mn) with the same communication addresses are simultaneously announced, the collision of said same communication addresses is identified and resolved.