Patent SG-11201804700V-A (SG)
Title: Devices and methods for simulating a function of a liver tissue
Inventor: HAMILTON GERALDINE
IPC: A61K35/407
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ires.. 00)d (43) International Publication Date .... ...1701 8 June 2017 (08.06.2017) W I P0 1 PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111111111 2017/096282 Publication Al Number (51) International Patent Classification: (74) Agent: CARROLL, Peter G.; Medlen & Carroll, LLP, A61K 35/407 (2015.01) C12N 5/071 (2010.01) 1440 Broadway, Suite 510, Oakland, California 94612 C12N 5/00 (2006.01) (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2016/064795 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 2 December 2016 (02.12.2016) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/263,246 4 December 2015 (04.12.2015) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (71) Applicant: EMULATE, INC. [US/US]; 27 Drydock, Bo- ZW. ston, MA 02100 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: HAMILTON, Geraldine; 222 Hurley Street, kind of regional available): ARIPO (BW, GH, protection Cambridge, MA 02141 (US). JANG, Kyung, Jin; 2 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Greenmeadow Ln, Andover, MA 01810 (US). HANEY, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Suzette; 39 Curve Street, Dedham, MA 02026 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, RONXHI, Janey; 155 Kendrick Ave T5, Quincy, MA DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 02169 (US). KODELIA, Konstantia; 9 Colbourne Cres- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, cent #2, Brookline, MA 02445 (US). PARK, Hyoung, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Shin; 42 Summit St, Newton, MA 02458 SLIZ, Jo- GW, KM, ML, MR, NE, SN, TD, TG). (US). Daniel; 5 Greenwich Park, Apt 4, Boston, MA 02218 siah, Published: (US). PETROPOLIS, Debora; 389 Columbia Street, #2, Cambridge, MA 02141 (US). LEVNER, Daniel; 55 Se- — with international search report (Art 21(3)) Ave, 5C, Brookline, MA 02446 (US). wall — (54) Title: DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A LIVER TISSUE 1A -1B Figs. A B 11 .4t ei ot ei v: cr\ 0 IN 1-1 (57) : Provided = bodiments, the devices can \" simulate a function of a dog 0 herein. herein relates to devices for simulating a be used liver Schematic I u of Human to simulate a function of a human liver tissue. In some embodiments, the devices can be used to tissue. Endothelial cell culture Liver Structure Liver-on-a-Chip Design function of a tissue and methods of using the same. In some ern- media for long-term culture of endothelial cells are also described