baber/WOPTO huggingface dataset:
Patent DK-0677533-T3 (DK)
Inventor: RAJEWSKY KLAUS
IPC: C07K14/52
Filed: 1995-04-12
Granted: 2005-05-30
Abstract: Novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof are disclosed. The method involves genetically engineering a host animal so that it does not biosynthesize at least one epitope of the self-antigen and utilizes the lack of self-tolerance of the host to the epitope to produce antibodies specific to the antigen. The invention also encompasses the AMABs produced by the methods. The invention further encompasses methods of isolating cells by using such AMABs that have specificity for a cell surface antigen.
Patent DK-0755303-T3 (DK)
Inventor: PONCEBLANC HERVE
IPC: C07B61/00
Filed: 1995-03-30
Granted: 1998-10-12
Abstract: Catalytic compositions including a carrier coated with an active phase based, in particular, on bismuth, molybdenum and/or tungsten, cobalt, nickel, iron and oxygen, and doped with phosphorus and at least one alkaline element, said active phase constituting 15-33 wt % of the catalytic composition, wherein the active phase has an atomic ratio 100 x (P + alkaline elements)/Ni of 0.9-10. The use of such catalytic compositions for preparing unsaturated aldehydes by oxidising the corresponding olefins is also disclosed.
Patent DK-0732914-T3 (DK)
Inventor: CASTILLO ERNESTO J
IPC: A61K47/32
Filed: 1995-11-16
Granted: 2001-11-05
Abstract: Stable formulations of positively charged, hydrolytically unstable drug compounds are obtained by adding a sulfated polyvinyl alcohol copolymer to the formulations.
Patent DK-0800481-T3 (DK)
Inventor: HAUG HELMAR
IPC: C02F1/70
Filed: 1995-12-27
Granted: 1999-05-10
Abstract: To decrease the nitrate content of water, it is proposed to reduce nitrate to nitrogen in two stages. The first of these stages is a photochemical reduction to nitrite, and the second stage is a reduction of nitrite to nitrogen using amidosulphuric acid.
Patent DK-0733357-T3 (DK)
Inventor: BOLTRI LUIGI
IPC: A61K8/39
Filed: 1996-03-18
Granted: 2002-10-28
Abstract: The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.
Patent DK-0787671-T3 (DK)
Inventor: FELDHAUS BERND
IPC: B65G53/52
Filed: 1996-09-13
Granted: 2001-06-25
Abstract: The cartridge can be releasably mounted in a transport system and consists of a housing (22) with bore in which a porous sintered metal part (21) is mounted and through which a gas, used e.g. for the transport of a powder, flows. The sintered part (21) lies with a shoulder against a flange at the end of the bore in the housing (22) and extends with its front beyond the rear face (22a) of the housing. The bore (23b), through which the gas flows in the direction 'F', narrows down to form a jet (23c) immediately upstream of the sintered part.
Patent DK-0758020-T3 (DK)
Inventor: SWINKELS BART WILLEM
IPC: C12N15/09
Filed: 1996-08-05
Granted: 2009-04-06
Abstract: The present invention discloses novel amdS genes from fungi previously not known to contain an amdS gene, such as Aspergillus niger and Penicillium chrysogenum. The novel amdS genes can be used as homologous selectable marker genes in the transformation of these fungi. Alternatively, the cloned amdS genes can be used to inactivate the endogenous copy of the gene in order to reduce the background in transformation experiments.
Patent DK-0779284-T3 (DK)
Inventor: MANN ANDRE
IPC: A61P25/18
Filed: 1996-12-09
Granted: 2002-10-07
Abstract: N-(4-(4-Phenyl-piperidino or -piperazino)-butyl)-2-naphthamide derivatives of formula (I) and their salts are new. Z-Y = N-CH2, C=CH or CH-CH2; R1 = H, F, Br, I, OH, OMe, CN or NO2; R2 = H, Br, OH, OMe, CN or NO2; R3, R4 = H, Cl, OMe, Me or electron-attracting group. Also claimed are medicaments for complementary treatment of Parkinson's disease containing dopamine D3 receptor agonists (A); and the use of (A) for preparing such medicaments.
Patent DK-0819258-T3 (DK)
Inventor: PAUL CLEMENT NICOLSON
IPC: C08K3/00
Filed: 1996-03-22
Granted: 2002-01-21
Abstract: An ophthalmic lens is disclosed which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
Patent DK-0869738-T3 (DK)
Inventor: BAE KYONGTAE T
IPC: A61B6/03
Filed: 1996-09-30
Granted: 2004-06-21
Abstract: A method and apparatus are disclosed for predicting prior to injection an organ specific contrast enhancement in a patient for a preselected contrast injection protocol for pre-determining a computed tomography scan. The invention is preferably implemented in a computer program which creates a mathematical model of human cardiovascular physiology in a hypothetical patient with a specific body habitus subjected to the pre-selected contrast injection protocol. The predicted contrast enhancement is then displayed for operator approval and may be then used to control a CT scanner or contrast injector system, to perform the injection and scan with the pre-selected injection protocol and scan parameters. The mathematical model includes models of organs and vessels using differential equations to describe mass transport of contrast agent through the cardiovascular system. Also disclosed are a method and apparatus for predicting optimum injection protocol for contrast agent by analyzing the predicted enhancement levels and updating the injection protocol until acceptable enhancement levels are predicted as well as a method and apparatus for determining an optimum scan interval when enhancement levels are predicted to exceed a threshold level for a time period greater than the scan duration. Further disclosed is a method and apparatus for monitoring a region of interest in the patient different from the region to be scanned after injection to calibrate the mathematical model and more accurately predict enhancement levels in the tissue to be scanned and calculate the optimum scan parameters.
Patent DK-0858467-T3 (DK)
Inventor: FUTREAL PHILLIP ANDREW
IPC: C12N1/15
Filed: 1996-11-25
Granted: 2004-06-14
Abstract: The identification and sequencing of the BRCA2 gene is disclosed as well as the amino acid sequence of the corresponding BRCA2 polypeptides. BRCA2 alleles including those with mutations in the BRCA2 gene which are associated with a predisposition to develop cancer, especially breast and ovarian cancer are also disclosed. The present invention further relates to polypeptides encoded by the above nucleic acid. The present invention further relates to uses of much BRCA2 nucleic acid and BRCA2 polypeptides, in particular in the diagnostic, prognostic or therapeutic treatment of cancer.
Patent DK-0930980-T3 (DK)
Inventor: O'BRIEN JOHN M
IPC: B60C3/00
Filed: 1997-10-17
Granted: 2006-07-31
Abstract: A traction device for vehicle wheels comprises an expandable and contractible member (10) mounted next to a wheel (70) or in between dual wheels (12, 14). In another embodiment the device comprises an air chamber (106, 134) formed in the tread of the tire (120).
Patent DK-0916003-T3 (DK)
Inventor: PEULER RAIMUND
IPC: F16C33/10
Filed: 1997-07-05
Granted: 2001-02-05
Abstract: A sports field, in particular for team sports such as football, has a playing field (20) which consists of a overing made of grass, granulates or other natural and/or artificial materials, placed on an infrastructure (21), in particular made of earth and/or gravel. Also disclosed is a process for horizontally displacing the sports field (20). To allow such a sports field to be horizontally displaced, the sports field is arranged on a preferably trough-shaped supporting frame (22) substantially made of concrete and/or steel parts, and which can be displaced on sliding pads supported on fixed sliding tracks (23).
Patent DK-0925507-T3 (DK)
Inventor: NI WEI-CHAO
IPC: G01N33/543
Filed: 1997-09-08
Granted: 2002-09-09
Abstract: A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A composition comprising a non-denaturing surfactant and a reagent for use in the assay is provided. The probe is contacted with the composition during the assay such that hydrophobic material is substantially prevented from coating the probe on the automated analyzer. Compositions for preventing such probe coating are also described. Methods and compositions comprising a non-denaturing surfactant for enhancing the stability of reagents used in an assay are also described.
Patent DK-0999859-T3 (DK)
Inventor: RIVAROSSA ALBERTO
IPC: A61L15/00
Filed: 1998-07-28
Granted: 2006-03-27
Abstract: The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anastomoses to create a physical hemostatic barrier and to prevent scar tissue formation and formation of post-surgical adherence of the vessels to the surrounding tissues.
Patent DK-1117808-T3 (DK)
Inventor: BURLINGAME RICHARD PAUL
IPC: C12N9/38
Filed: 1999-10-06
Granted: 2005-04-25
Abstract: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.
Patent ES-2220272-T3 (ES)
Inventor: KAWALLA RUDOLF PROF DR-ING
IPC: C21D8/02
Filed: 2000-02-16
Granted: 2004-12-16
Abstract: Hot rolled microalloyed steel strip production, uses inter-stand cooling to allow final rolling passes at a temperature below the recrystallization temperature.  Production of hot rolled strip (W) of unalloyed or low alloy steel containing micro-alloying elements, from optionally reheated continuously cast slabs, plates or strip, comprises:  (a) feeding strip into the first stand (F1) of a tandem finishing line (FS) at ≥ 30 degrees C above the recrystallization end temperature (TR);  (b) continuously rolling the strip in one or more passes in the austenite recrystallization region;  (c) cooling the strip between adjacent stands (F1-F7) by cooling devices (K2-K7) to ≥ 20 degrees C below the recrystallization end temperature (TR) at a cooling rate of ≥ 10 degrees C/sec.; and  (d) rolling the strip at below the recrystallization end temperature (TR) in several passes with a total deformation ( epsilon h) of ≥ 30%.  An Independent claim is also included for a hot strip line for carrying out the above process.
Patent ES-2224969-T3 (ES)
Inventor: CREMONESE ROBERTO
IPC: F16L13/14
Filed: 2000-06-15
Granted: 2005-03-16
Abstract: Coupling bushing, preferably for gas cooking appliances, such as gas ranges and top cooking plates, said bushing being bored internally for the entire lenght thereof and joined to a short edge of diameter smaller with respect to that of the remaining bushing portion, wherein the bushing inner hole is provided with a threaded portion for connection of at least a gas supply piping and a knurled not threaded portion for connection of at least a tube distributing gas or burner of the cooking appliance. The tube distributing gas (9) is shaped at its end portion (15) with at least a radial projection (16) and a plurality of longitudinal hollows (17) and longitudinal strips (18) distributed alternate from each other, and the longitudinal strips (18) are compressed against said not threaded portion (14) of bushing, inserted on to said strips (18) and said longitudinal hollows (17), under abutment condition of the same against said radial projection (16). <IMAGE>
Patent ES-2326206-T3 (ES)
Title: Dispositivo para la verificacion del juego axial y del juego de articulacion en vehiculos.
Inventor: WANNER HUBERT
IPC: G01M17/007
Filed: 2000-07-06
Granted: 2009-10-05
Abstract: Dispositivo para la verificación del juego axial y del juego de articulación en automóviles, que contiene dos elementos de soporte (2, 3) dispuestos para la formación de un soporte prismático del neumático (6), en el que al menos un elemento de soporte (2, 3) es desplazable transversalmente al eje longitudinal del automóvil, caracterizado porque - los dos elementos de soporte (2, 3) para el soporte prismático del neumático (6) son dos placas de soporte (2, 3) acodadas, separadas una de la otra, que están dispuestas una detrás de la otra en la dirección longitudinal del vehículo, - una placa de soporte (2) es desplazable en dos barras de guía paralelas (8, 9) sobre una placa de fondo (10) en la dirección transversal del vehículo por medio de una unidad de accionamiento (23, 24) y presenta una superficie de soporte (4) inclinada, y - la segunda placa de soporte (3) es giratoria verticalmente por medio de una instalación de elevación (36) alrededor de una barra (29), dispuesta transversalmente al eje longitudinal del automóvil, desde una posición inferior con superficie de soporte horizontal (5) hasta una posición elevada con superficie de soporte (5) inclinada.
Patent ES-2231145-T3 (ES)
Inventor: LUSCHER MARCEL
IPC: B23Q16/08
Filed: 2000-06-26
Granted: 2005-05-16
Abstract: The unit (1) has a chuck (1) to clamp a work piece support, with a centring pin (22) on the chuck co-operating with second positioning devices on the work piece support. The pin and second positioning devices co-operate in pairs as alignment elements and position the work piece support in three orthogonal axes and the desired angle. A clamp device (12,18) fixes the clamping force of the work piece support in position at the chuck. The clamp device has a number of clamping balls (18) and an annular groove. The line of the clamping force of the clamp device lies in a cylindrical casing surface (MF) of the chuck, which is parallel the chuck axis (Z) and intersects the centring pin and second positioning devices.
Patent ES-2204555-T3 (ES)
Title: Procedimiento mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina.
Inventor: CAVAZZA CLAUDIO
IPC: C07C227/18
Filed: 2000-03-16
Granted: 2004-05-01
Abstract: Un procedimiento para la preparación de una sal de L(-)-carnitina estable y no higroscópica, seleccionada del grupo formado por el fumarato ácido de L(-)-carnitina (1:1) y el L(+)-tartrato de L(-)-carnitina (2:1), que comprende: (a) mezclado a temperatura ambiente, en cualquier orden deseado, (1) sal interna de L(-)-carnitina; (2) ácido fumárico o ácido L(+)-tartárico, respectivamente en cantidad equimolar o en la mitad de la cantidad equimolar con respecto a la sal interna de L(-)- carnitina; y (3) 5-9%, preferiblemente 6-8%, en peso de agua calculado sobre el peso de la mezcla (1)+(2)+(3); (b) calentamiento en agitación de la mezcla anterior a una temperatura de 100-120ºC para obtener una masa fundida sustancialmente incolora y trasparente; (c) enfriado de la masa fundida hasta una solidificación completa; y (d) trituración de la masa solidificada para obtener un granulado o polvo que posea el tamaño de partícula deseado.
Patent ES-2243270-T3 (ES)
Title: Dispositivo de resuspension de un agente de contraste.
Inventor: HUGHES MICHAEL SCOTT
IPC: A61M5/14
Filed: 2000-05-19
Granted: 2005-12-01
Abstract: Un dispositivo para proporcionar un volumen de un agente (12) formado por un recipiente (10, 14) con un puerto de salida (24, 56) y una pared lateral cerrada que se extiende desde el puerto de salida (24, 56) para definir un espacio interior cerrado adaptado para contener un fluido propulsor (16) y una red tubular (8a, 8c, 8g, 18) colocada en dicho espacio interior cerrado de dicho recipiente (10, 14), caracterizado en que dicha red tubular (8a, 8c, 8g, 18) está formada por un único pasaje helicoidal acoplado a dicho puerto de salida (24, 56) de dicho recipiente (10, 14) y una entrada de la obertura de dicho pasadizo helicoidal acoplada a dicho espacio interior cerrado de modo que el fluido propulsor (16) que fluye por dicha entrada y a través de dicho pasadizo helicoidal en contacto directo con el agente (12) libere subvolúmenes del agente a través de dicha salida y a través dicho puerto de salida (24, 56).
Patent ES-2216902-T3 (ES)
Inventor: SUTORIS HEINZ FRIEDRICH
IPC: C07B63/04
Filed: 2000-06-09
Granted: 2004-11-01
Abstract: A process for preventing undesired polymerization is conducted by maintaining an effective concentration of a stabilizer which comprises N-oxyl radicals in a mixture containing ethylenically unsaturated compounds, wherein(i) an electronic signal which correlates with the concentration of the N-oxyl radicals in the mixture is obtained periodically or continuously,(ii) the electronic signal is compared with a reference value, and(iii) addition of a stabilizer to the mixture is controlled according to the comparison (ii).The signal is preferably obtained by ESR measurement. The process permits efficient use of the stabilizer.
Patent ES-2269160-T3 (ES)
Inventor: KRATZ FELIX
IPC: A61P43/00
Filed: 2000-06-07
Granted: 2007-04-01
Abstract: Production of an injectable pharmaceutical composition comprises dissolving a drug derivative (I) in an injectable carrier liquid, where (I) comprises a drug linked to a protein-binding group via a spacer and where the spacer or the linkage between the drug and the spacer is pH-dependently or enzymatically cleavable in vivo to release the drug. An independent claim is also included for a drug derivative of type (I) in which the drug is not a cytostatic agent.
Patent ES-2258978-T3 (ES)
Inventor: BONNET HENRI
IPC: B65G47/49
Filed: 2000-08-03
Granted: 2006-09-16
Abstract: A feeding system and method for placing a plurality of objects within a single designated destination area of a sorting system to increase the throughput rate of the system. The disclosed sorting system includes a plurality of carriages movable under the control of a programmable controller between the loading and unloading stations of the sorting system, each carriage carrying a tilt tray. The geographic destination of each of the objects to be placed on a tray, as well as a dimension of each of the objects to be placed on a tray, is determined by an optical scanner and a measuring device. The controller uses the dimension information to determine whether more than one object having the same geographic destination may be placed on the same tray. The invention is adaptable for use with other types of sorting systems.
Patent ES-2204713-T3 (ES)
Title: Inhibidores de proteasa ns3 de hcv.
Inventor: FATTORI DANIELA
IPC: C12N9/99
Filed: 2000-11-02
Granted: 2004-05-01
Abstract: Un compuesto de la **fórmula**, o una sal o éster farmacéuticamente aceptable en la que se representa un anillo de benceno o un anillo carbocíclico no aromático y (n) es el número total de átomos de carbono en el anillo carbocíclico y es entre 4 y 8; A es i) ciclohexilmetil- o ii) fenilo opcionalmente sustituido con entre 1 y 3 sustituyentes independientemente seleccionados entre halo, alquilo C1- C4, fluoroalquilo C1-C4, o alquilo C1-C4, O- fluoroalquilo C1-C4 y Ra-C(=O)O-, en donde Ra es naftilmetil-, 2, 2-difeniletil-, o carboxiciclohexil-; B es hidrógeno, alquilo inferior de entre 1 y 6 átomos de carbono o es un grupo aralquilo que contiene entre 7 y 18 átomos de carbono en el cual el grupo arilo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halo, alquilo C1-C4, fluoroalquilo C1-C4, -O-alquilo C1- C4 y ¿O-fluoroalquiloC1-C4; D es hidrógeno, o un grupo de la **fórmula** en las que Y es hidrógeno, un grupo alquilo que contiene entre 1 y 6átomos de carbono o un grupo cicloalquilo que contiene entre 3 y 8 átomos de carbono; cada uno de los estereocentros a y b está independientemente en la configuración R o en la configuración S; p es 1 ó 2; y X se selecciona entre grupos hidroxilo y -O-alquilo C1-C6; a condición de que si B es hidrógeno o alquilo inferior, D no sea también hidrógeno y si D es hidrógeno B es un grupo aralquilo.
Patent ES-2225254-T3 (ES)
Inventor: HANSEN JOERN SKOVLOEBER
IPC: A63H33/08
Filed: 2000-11-16
Granted: 2005-03-16
Abstract: A toy building set comprising: a sensor (200, 301) capable of recording revolution of a wheel (501, 502), a computer (101, 303) having a display (302), said computer (101, 303) being connectible to the sensor (200, 301) for receiving a revolution signal (S) from the sensor, said computer being capable of converting the revolution signal into a value in dependence on a factor, said value representing the revolution and being displayable on the display. The sensor (200, 301) comprises coupling means (210) for coupling to building elements (101, 504, 505) having complementary coupling means (107), said coupling means being arranged in a modular system with modular units (M1, M2), and the computer (101, 303) is arranged such that the factor may be specified by stating a transverse dimension of the wheel in a plurality of modular unit (M1, M2). The computer may thereby be set to a wheel size in a simple manner.
Patent ES-2233485-T3 (ES)
Inventor: STAHL BERND
IPC: A23L29/30
Filed: 2000-12-07
Granted: 2005-06-16
Abstract: An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.
Patent ES-2298168-T3 (ES)
Inventor: GSCHNEIDNER DAVID
IPC: A61K38/29
Filed: 2000-12-18
Granted: 2008-05-16
Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Patent ES-2240251-T3 (ES)
Title: Componente.
Inventor: HACKE FRANK
IPC: B29C65/56
Filed: 2001-02-22
Granted: 2005-10-16
Abstract: Componente con un cuerpo base (10) de un material relativamente duro y un revestimiento (12) de un material relativamente blando, que cubre por lo menos la superficie principal del cuerpo base limitada por un perímetro exterior, caracterizado porque una zona del borde del revestimiento, que sale del perímetro exterior de la superficie principal, presenta una armadura (14) de un material relativamente duro, que ajusta en el cuerpo base (10).