Patent SG-11201903615W-A (SG)
Title: Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
Inventor: ZHANG BIN
IPC: A61K9/127
Filed: 2017-11-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 May 2018 (11.05.2018) Hu omits I iolo olom11 001110 HOHOMEHOEIE (10) International Publication Number WO 2018/083470 Al WIPO I PCT (51) International Patent Classification: A61P 35/00 (2006.01) A61K 31/513 (2006.01) A61K 31/4453 (2006.01) A61K 31/519 (2006.01) A61K 31/4178 (2006.01) A61K 9/127 (2006.01) (21) International Application Number: PCT/GB2017/053293 (22) International Filing Date: 01 November 2017 (01.11.2017) (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 18/083 47 0 Al (26) Publication Language: English (30) Priority Data: 62/416,317 02 November 2016 (02.11.2016) US (71) Applicant: IPSEN BIOPHARM LTD. [GB/GB]; Ash Road, Wrexham Industrial Estate, Wrexham LL13 9UF (GB). (72) Inventors; and (71) Applicants: ZHANG, Bin [US/US]; 55 Hill Road, Apt 307, Belmont, Massachusetts 02478 (US). BRAUN, Stephan [DE/FR]; 37, rue Paul Valery, 75116 Paris (FR). (72) Inventors: FITZGERALD, Jonathan Basil; 32 Magno- lia Street, Arlington, Massachusetts 02474 (US). KALRA, Ashish; 19 Burnham Street, Apt. D2, Belmont, Massa- chusetts 02478 (US). LEONARD, Shannon; 28 Highland Park, Peabody, Massachusetts 01960 (US). (74) Agent: OATES, Edward Christopher et al.; Carpmaels & Ransford LLP, One Southampton Row, London WC1B 5HA (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: TREATING GASTRIC CANCER USING COMBINATION THERAPIES COMPRISING LIPOSOMAL IRINOTECAN, OXALIPLATIN, 5-FLUORURACIL (AND LEUCOVORIN) (57) : Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of gastric cancer, including treatment of patients diagnosed with previously untreated gastric cancer. The combination therapy can include the administration of liposomal irinotecan, oxaliplatin, leucovorin and 5-fluorouracil once every two weeks.