baber/WOPTO huggingface dataset:
Patent MX-2020009519-A (MX)
Title: Yap1 inhibitors that target the interaction of yap1 with oct4.
Inventor: LAWRENCE NICHOLAS J
IPC: A61K31/496
Filed: 2019-03-14
Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
Patent MX-2020011001-A (MX)
Title: Exothermic welding system and method.
Inventor: DUART ÀLVAREZ DE CIENFUEGOS DANIEL
IPC: B23K103/10
Filed: 2018-04-18
Abstract: The system comprises a mold (6) which in turn comprises: a weld cavity (4); housings (5) for the components (1) to be welded; a crucible-funnel (7) communicated with the weld cavity (4) for housing filling material (3); at least one additional cavity (10) for housing an exothermic mixture (2); and an inner shell (11) that separates the crucible-funnel (7) and the at least one additional cavity (10) in order to transmit heat produced in the exothermic reaction from the additional cavity (10) to the crucible-funnel (7). The system of the invention allows the exothermic mixture to be isolated to prevent contact with the filling material (3) and to prevent it from reaching the weld cavity (4). The system can further include a first filler (13) and a second filler (16), arranged to be mounted over the mold (6) for introducing the filling material (3) and the exothermic mixture (2), respectively.
Patent MX-2021000806-A (MX)
Title: Personal protection and ventilation system.
Inventor: JASCOMB JERALD T
IPC: A42B3/00
Filed: 2019-08-23
Abstract: A personal protection and ventilation system (100) is provided. The system (100) includes a gown (101, 160) having front (158) and rear panels (120), a hood (178), and visor (178, 180); a fan (182); an air tube (184); and a helmet (190). The fan (182) is positioned between the wearer and a body-facing surface of the rear panel (120, 122). The front panel (102) and at least a portion (256, 258) of the hood (178) are formed from a first material (200, 256, 300) including a first spunbond layer (146A, 146C, 148, 152), a spunbond-meltblown- spunbond laminate, and a liquid impervious elastic film (144) disposed therebetween. The first material (200, 256, 300) has an air volumetric flow rate of less than about 1 standard cubic feet per minute (scfm). The rear panel (120, 122) is formed from a second material (200, 256, 300) including a nonwoven laminate having an air volumetric flow rate of about 20 scfm to about 80 scfm. Therefore the fan (182) is able to intake a sufficient amount of air from the environment through the rear panel (120, 122) to provide cooling/ ventilation to the hood (178)..
Patent MX-2021002373-A (MX)
Title: Car-expressing t cells and car expression vector.
Inventor: TAKE Chihiro
IPC: A61P35/02
Filed: 2019-08-30
Abstract: Provided are immunocytes (CAR-T cells, etc.) having a higher antitumor activity than immunocytes (CAR-T cells, etc.) expressing a CAR singly (not expressing a cytokine and/or a chemokine). The T cells provided in one aspect of the present invention express: (1) a chimeric antigen receptor (CAR); (2) at least one member selected from the group consisting of interleukin-15 (IL-15), interleukin-18 (IL-18), interleukin-21 (IL-21) and interleukin-27 (IL-27); and (3) CC chemokine ligand 19 (CCL19).
Patent MX-2021003164-A (MX)
Title: Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions.
Inventor: COLLIN FRANCOIS
IPC: C12Q1/6886
Filed: 2019-09-19
Abstract: Disclosed herein are methods for identifying patients with pancreatic cancer and subjects at risk for developing pancreatic cancer, methods for monitoring a patient with an identified pancreatic lesion, methods for evaluating the effectiveness of a treatment used for a patient with pancreatic cancer, and methods for selecting a therapy for treating pancreatic cancer in a particular patient. The invention makes use of hydroxymethylation biomarkers, which in combination with one or more clinical parameters and optionally one or more additional types of biomarkers and/or patient-specific risk factors, exhibit a hydroxymethylation level that correlates with pancreatic cancer. Kits and other methods of use are also provided.
Patent MX-2021004315-A (MX)
Title: Vehicle wheel and methods of making and using a vehicle wheel.
Inventor: MASON DOUGLAS
IPC: B60B3/02
Filed: 2018-10-26
Abstract: A vehicle wheel for mounting at least two tires, an assembly comprising the vehicle wheel, methods of making the vehicle wheel, and methods of using the vehicle wheel. The vehicle wheel comprises a generally cylindrical first region, a generally cylindrical second region, a third region, and a fourth region. The first region comprises a first tire mount disposed about a circumference of an outer surface of the first region. The second region comprises a second tire mount disposed about a circumference of an outer surface of the second region. The third region is disposed intermediate and connecting the first region and the second region. The fourth region is integral with and extends radially inward from an inner surface of the third region. The fourth region is configured to mount to a vehicle axle. The first, second, third, and fourth regions are regions of a monolithic body.
Patent MX-2021005248-A (MX)
Title: B-cell activating cd73 antibodies.
Inventor: HOTSON ANDREW
IPC: A61K39/395
Filed: 2019-11-05
Abstract: Provided herein are, inter alia, methods and compositions using and including anti-CD73 antibodies capable of activating B cells, and affecting the redistribution of B cells from lymphoid tissues to lymphoid organs. This previously unknown and unique effect of anti-CD73 antibodies may be useful for the treatment of various indications, for example, enhancing immunity to immunogenic cancers, treating autoimmune disease (e.g., multiple sclerosis), inflammatory diseases, or infectious disease.
Patent MX-2021011033-A (MX)
Title: Methods and compositions for treating produced water.
Inventor: HESAMPOUR MEHRDAD
IPC: C02F1/54
Filed: 2020-03-12
Abstract: The present embodiments generally relate to the treatment of produced water such as produced water resulting from an industrial process such as one involving the use of copious amounts of water and the addition of one or more polymers such as water soluble and/or viscosifying or thickening polymers, in particular enhanced oil recovery processes or another processes resulting in polymer flooded produced water. These treatment methods include contacting the produced water with one or more PACl-based coagulants, wherein said treatment may result in desired effects, such as, for example, a reduction of the viscosity of said produced water and/or the removal of polymers which are contained therein.
Patent MX-2021012387-A (MX)
Title: Collapsible air filter assemblies.
Inventor: TAGGART JEFFREY SILVER
IPC: B01D46/00
Filed: 2020-04-09
Abstract: A collapsible air filter assembly for a heating and ventilation air conditioner (HVAC) system includes a filter element, and a frame supporting the filter element. The frame includes at least two edges each including a respective spring element configured to be moveable between an open state and a bent state. A compressible air filter assembly for an (HVAC) system includes a filter medium having rounded pleats configured to collapse and rebound in a controlled and repeatable manner between a compressed state and an original uncompressed state. A soft-wrapped filter assembly includes a frame in a box configuration. The frame includes rigid edges and openings to permit airflow. A filter element is encased by the frame. Flexible edge covers mounted on respective edges of the frame to provide an air seal in an HVAC system.
Patent MX-2022001172-A (MX)
Title: Securing element.
Inventor: WAGNER FRANK
IPC: F16B19/02
Filed: 2020-07-22
Abstract: The invention relates to a securing element (1), in particular a mounting bolt, comprising a positioning section (10), an intermediate section (20) and a fitting section (30), wherein the securing element (1) extends along a longitudinal axis (L), wherein the positioning section (10) has positioning structures, in particular a thread, wherein the intermediate section (20) is arranged in the direction of the longitudinal axis (L) between the positioning section (10) and the fitting section (30), wherein the fitting section (30) is substantially rotationally symmetric around the longitudinal axis, wherein the fitting section (30) has an outer support surface (34), wherein the support surface (34) has a clearance fit, and wherein there is a lubrication groove (32) at least in the fitting section (30).
Patent MX-2022003432-A (MX)
Title: Methods and compositions comprising an anti-ctla4 monoclonal antibody with reduced host cell proteins and increased polysorbate-80 stability.
Inventor: CHMIELOWSKI REBECCA A
IPC: C07K1/22
Filed: 2020-09-18
Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.
Patent MX-2022005253-A (MX)
Title: Polyomavirus neutralizing antibodies.
Inventor: KOVACS STEVEN
IPC: C07K16/08
Filed: 2018-03-15
Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
Patent MX-2022009885-A (MX)
Title: Compositions and methods for allogeneic transplantation.
Inventor: BOITANO ANTHONY
IPC: C07K16/28
Filed: 2021-02-18
Abstract: Described herein are compositions and methods useful for the depletion of CD45+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for allogeneic hematopoietic stem cell transplant therapy and to improve the engraftment of allogeneic hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
Patent MX-2022011660-A (MX)
Title: Method for producing ethylene from carbon dioxide.
Inventor: GARMON MICHAEL A
IPC: C12P5/02
Filed: 2021-03-19
Abstract: A process comprising (i) providing a gaseous stream including greater than 1 % by volume carbon dioxide; (ii) providing water; (iii) converting the carbon dioxide and the water to an organic intermediate and oxygen gas in the presence of light; (iv) separating the oxygen gas from the organic intermediate; and (v) converting the organic intermediate to ethylene and carbon dioxide after said step of separating the oxygen gas from the organic intermediate.
Patent MX-2023000100-A (MX)
Title: AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS.
Inventor: COMBS ANDREW P
IPC: C07D241/20
Filed: 2020-09-04
Abstract: This application relates to compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-Î³ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Patent MX-PA00006847-A (MX)
Title: Drive mechanism and head rail for a blind.
Inventor: KONRAD WELFONDER
IPC: E06B9/36
Filed: 2000-07-12
Abstract: A head rail (2) for a vertical blind, the head rail (2) being elongate and having a drive mechanism at one end for selectively tilting and retracting slats of the vertical blind along the length of the head rail, the drive mechanism including a rotatable tilt drive (6) for tilting slats, a rotatable retract drive (8) for retracting and deploying slats, and a transmission for rotating the tilt drive and the retract drive by means of a single rotatable source, wherein the transmission includes a clutch for rotating the tilt drive (6), the clutch incorporating a lost motion mechanism whereby, after a predetermined number of rotations in the same direction, transmission by the clutch to the tilt drive (6) is disengaged and wherein the transmission includes a control gear which is located at a position along the length of the head rail (2) so that it can be meshed with teeth of an external drive source (4).
Patent MX-PA00010419-A (MX)
Title: Novel nucleotide sequences coding for the poxb gene.
Inventor: NICOLE DUSCH
IPC: C12R1/15
Filed: 2000-10-24
Abstract: Isolated polynucleotide (I) comprises: (a) a sequence that is at least 70% identical to a sequence that encodes a polypeptide comprising the fully defined 579 amino acid sequence (S2) given in the specification; (b) encodes a protein at least 70% identical with (S2); (c) a sequence complementary to (a) or (b); or (d) a sequence comprising at least 15 consecutive bases from (a), (b) or (c). Independent claims are also included for the following: (1) a vector comprising (I); (2) coryneform bacteria, functioning as host cell, that include a deletion or insertion in the poxB gene; and (3) production (M) of L-amino acids, especially L-lysine, by fermenting bacteria in which the poxB gene is at least partly suppressed.
Patent MX-PA01005256-A (MX)
Inventor: DANIEL THOMAS
IPC: C08F20/04
Filed: 2001-05-25
Abstract: The invention relates to hydrogels capable of absorbing aqueous fluids, which hydrogels are produced by polymerization of olefinically unsaturated carboxylic acids or their derivatives. The hydrogels are characterized in that before, during or after the polymerization reaction and before drying a silicic acid alkali salt of the general formula (I) M2O×nSiO2 is added to the polymerization reaction mixture. In said formula M is an alkali metal and n is a number between 0.5 and 4. The hydrogel obtained in this way is then dried at an elevated temperature. The invention also relates to a method for producing said hydrogels and to their use for absorbing aqueous fluids.
Patent MX-PA01009847-A (MX)
Title: Derivatives of pyrimido[6,1-a]isoquinolin-4-one.
Inventor: OXFORD ALEXANDER WILLIAM
IPC: C07D471/04
Filed: 2000-03-29
Abstract: Compounds of general formula (I) wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents OCH2 or a group CR3R4, wherein each of R3 or R4 independently represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl group; R6 represents a hydrogen atom or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, amino, C1-6 alkylamino, di(C1-6) alkylamino or C2-7 acylamino group; each of R7 and R8 independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy, C3-6 cycloalkyl; R9 represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy or C3-6 cycloalkyl group, or salts thereof are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3-methyl-2-mesitylimino-2,3,6, 7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one) and do not have trequinsin's very bitter taste.
Patent MX-PA01011979-A (MX)
Title: Synchronization of broadcast facilities via satellite and/or microwave link.
Inventor: BRAUN WARREN L
IPC: H04H20/67
Filed: 2000-05-22
Abstract: Interference effects between television transmitters for amplitude modulated or digital video and operating on a common allocated channel or frequency is avoided while discrimination is improved by synchronizing carrier signals for a plurality of transmitters. Booster transmitters for correcting coverage anomalies can operate of the same channel or frequency rather than requiring a different channel or frequency presently required in translators; making all allocable channels available for diverse broadcast programming. Discrimination between transmitters operating on the same channel or frequency but with potentially differing programming can be achieved with directional antennas. Synchronization of carrier signals is achieved by frequency multiplication of a tone relayed over a microwave transmission channel by an integral power of two using one or more serially connected full-wave rectifier stages and tuned filters.
Patent MX-PA01012143-A (MX)
Title: Document transfer device.
Inventor: LAPSTUN PAUL
IPC: H04L9/30
Filed: 2000-05-24
Abstract: A system is provided having a sensing device for sensing coded data printed on a print media surface which is installed with a secret key and a first identifier which uniquely identifies the sensing device, a printer installed with a second identifier which uniquely identifies the printer, and a server installed with the first and second identifiers. The printer obtains the first identifier from the sensing device and communicates the first and second identifiers to the server. The server determines from the received first and second identifiers whether the sensing device should be registered with the printer and if so, authenticates the sensing device by verifying an encryption from the sensing device, using the secret key, of a challenge message. Upon successful authentication, the sensing device is registered in the server so as to be associated with the printer.
Patent MX-PA02000878-A (MX)
Title: Hops acid antibacterial compositions.
Inventor: WILLIAM KING
IPC: A01N65/00
Filed: 2000-07-27
Abstract: An antibacterial composition of matter comprising: a) one or more hops acid or hops acid derivatives or hops resin or hops resin derivatives; and b) one or more food grade surfactants, surface active agents, chelating agents, antioxidants, and/or organic acids is provided.
Patent MX-PA02002523-A (MX)
Title: Tubing conveyed fracturing tool and method.
Inventor: ESLINGER DAVID M
IPC: E21B43/26
Filed: 2002-03-08
Abstract: A tubing conveyed multi-position well treating tool having a tubular housing and a tubular inner member which are relatively positionable at "Set", "Treat", "Dump" and "Release" positions actuated by a mechanical indexing mechanism. The indexing mechanism is loade d by a spring, such as a compressed gas spring or mechanical spring, which urges the tubular housing away from the tubing connection of the inner tubular member, thus requiring no set-down forces for tool actuation or indexing. The treating tool is anchored within the well casing by hydraul ic pressure actuated buttons, thus eliminating the typical requirement for anchoring actuation by set-down forces. The treating tool is sealed within the casing by pressure energized packers whic h are activated by the hydraulic pressure of fluid supplied from the tubing. The tool provides a bypass passage to allow communication of the zones above and below the tool while isolating the straddled interval to be treated.
Patent MX-PA02002905-A (MX)
Title: Radiation crosslinked elastomeric materials.
Inventor: ZHANG JOHN JIANBIN
IPC: B32B25/14
Filed: 2000-09-15
Abstract: The present invention is a radiation crosslinked elastomeric material with improved elevated temperature properties and lotion resistance. The elastomeric material can be used alone or with skin layers to form an elastomeric film, such as a coextruded andor formed film. As a formed film the material of the present invention can provide a porous, macroscopicallyexpanded, threedimensional, elastomeric web. In a preferred embodiment, the elastomeric web is suitable for use in elasticized or bodyhugging portions of disposable absorbent articles such as side panels, waist bands, cuffs, or of health care products such as disposable diapers, dressings, bandages and wraps. The porous extensible polymeric webs of the present invention may also be used in other portions of the absorbent articles where a stretchable or breathable material is desired, such as topsheets or backsheets. The material of the present invention provides the additional benefits of improved elevated (e.g., body temperature) performance and lotion resistance. The elastomeric material of the present invention preferably exhibits improved elastomeric properties at body temperature and under load or stress for a specified period of time, with or without lotion applied. In a preferred embodiment, the elastomeric material comprises block copolymers, such as polystyrenebutadienepolystyrene block copolymers having a styrene content in excess of about 10 weight percent; at least one thermoplastic resin, such as vinylarene or polyolefins; and a processing oil, particularly a low viscosity hydrocarbon oil such as mineral oil. Antioxidants can be added as necessary.
Patent MX-PA02010820-A (MX)
Title: Antimicrobial transfer substrates and methods of use therewith.
Inventor: CHAN MARIE S
IPC: A01N25/10
Filed: 2001-05-17
Abstract: Specific transfer methods and articles to impart a metal ion based antimicrobial finish to recipient textile surfaces. Such treatments preferably comprise silver ions, particularly as constituents of inorganic metal salts or zeolites. In particular, the inventive method involves the application of a solid, inorganic antimicrobial material to a donor substrate (such as a dryer sheet), and the subsequent placement of such a substrate within a tumble drying machine containing textile fabrics and operating the machine. The donor substrate, upon contact with the recipient textile fabrics, transfers antimicrobially effective amounts of the metal ion based compounds to such recipient fabrics thereby imparting at least a temporary antimicrobial finish over at least a portion of such fabrics. The donor substrates, with either the antimicrobial compound alone or mixed with standard tumble dryer additives (such as perfumes, fabric softeners, fiber lubricants, and the like) are also contemplated within this invention.
Patent MX-PA02011460-A (MX)
Title: Carboxylate salts in heat storage applications.
Inventor: LIEVENS SERGE
IPC: C09K3/00
Filed: 2001-05-17
Abstract: The use of an alkali metal salt or alkaline earth metal salt or of a brine solution of a C1 C16 carboxylic acid, or a mixture thereof, as a medium for the storage and use of thermal energy. The salts or solution can be used in a heat exchange fluid or a lubricant or hydraulic fluid or soap.
Patent MX-PA03001002-A (MX)
Title: Process for the production of a layer part, in particular a reaction injection moulding process for the production of a polyurethane skin layer.
Inventor: DE WINTER HUGO
IPC: B29C33/48
Filed: 2001-07-31
Abstract: A process for the production by a moulding process of a micro-cellular or non-cellular elastomeric polyurethane skin layer or, more generally, to a process for the production of a composite comprising a first layer shaped part, which is made by a moulding process from a polyurethane reaction mixture, and a second layer shaped part which is adhered to the first part to form the composite. In order to avoid the use of release agents on the back side of the first layer shaped part, and thus the negative effect on the adhesion of the second layer shaped part, and the penetration of reaction mixture on this back side between the slides (9-10) of the mould, the mould surface (4) is covered on the back side of the moulding with a removable flexible covering, such as a film (12) or a membrane, with a removable rigid pre-shaped covering or with a permanent non-stick coating layer. <IMAGE>