baber/WOPTO huggingface dataset:
Patent IE-35106-L (IE)
Title: Phenoxy-hydroxypropylamines
IPC: C07C59/68
Filed: 1971-02-17
Abstract: 1308106 Substituted phenoxy-hydroxy propylamines HASSLE AB 19 April 1971 [18 Feb 1970] 21994/71 Heading C2C Novel compounds of the Formula IV wherein R<SP>1</SP> is isopropyl or t-butyl, A is a straight or branched C 1-4 alkylene chain and Z is -OR<SP>2</SP>, -SO 2 R<SP>2</SP>, -SOR<SP>2</SP>, -SR<SP>2</SP>, NR 3 -COR<SP>2</SP>, NR 3 SO 2 R<SP>2</SP> or NR<SP>3</SP>COOR<SP>2</SP> wherein R<SP>2</SP> is straight or branched C 1-3 alkyl and R<SP>3</SP> is hydrogen or a straight or branched alkyl radioal and pharmaceutically acceptable acid addition salts thereof may be prepared by (i) reacting a compound V wherein X is an unsubstituted ethylene oxide ring or -CHOHCH 2 -halogen with a compound R<SP>1</SP>NHCONHR<SP>1</SP> or R<SP>1</SP>NH 2 ; (ii) reductively alkylating IV wherein R<SP>1</SP> is H with acetone to produce IV, R<SP>1</SP> = iPr; (iii) alkylating IV R<SP>1</SP> = H with Hal-CH(CH 3 ) 2 where Hal is a halogen atom; (iv) hydrolysing a compound wherein R<SP>4</SP> is a hydrolytioally removable group; (v) hydrolysing a compound with strong acid or strong alkali (vi) hydrolysing or pyrolysing a compound wherein R<SP>6</SP> and R<SP>6</SP> are hydrogen, C 1-4 alkyl, aralkyl or aryl; (vii) hydrolysing or hydrogenolysing a compound wherein R<SP>7</SP> is an amine protecting group; (viii) reacting XCH 2 NHR<SP>1</SP> or XCH 2 NR<SP>1</SP>R<SP>7</SP> with a phenolate (ix) reducing a compound wherein B is -CHOHCO- or -COOH 2 -, (x) hydrolysing a compound wherein R<SP>8</SP> is C 1-4 alkyl, aralkyl or aryl or, (xi) hydrogenolysing a compound wherein Y means the benzene ring is substituted with 1 to 4 halogen atoms. The intermediates V may be prepared by reacting an appropriately para-substituted phenol with chlorohydrin followed in the case where X is CHOHCH 2 Cl, by treatment with hydrochloric acid. 2 - Hydroxy - 3 - [p - (methoxyethyl) - phenoxy]- N - isopropyl propionamide may be prepared by reacting the free acid with isopropylamine, the free acid in turn being prepared by condensingp-methoxy ethyl phenol with 2-hydroxy- 3-chloropropionic acid. A 1 - isopropylamino - 3 - [bromo - p - (#- methoxyethyl) - phenoxy] - propanol - 2 may be prepared by brominating p-(#-methoxyethyl)- phenyl to give a brcmo-p-(#-methoxyethyl)- phenol which is reacted with chlorohydrin followed by isopropylamine to yield the required compound. Pharmaceutical compositions of the compounds IV may be used for treatment of heart diseases and vascular diseases when administered orally, parenterally or rectally with excipients or diluents.
[GB1308106A]
Patent IE-840280-L (IE)
Title: Anthracycline compound
IPC: C12P19/56
Filed: 1984-02-07
Abstract: The present invention relates to the novel anthracycline compound serirubicine and a process for preparing the same by means of a microorganism. The compound according to the invention exhibits antitumor and antmicrobial axtivities and can, therefore, be used as medicament.
Patent IE-33743-L (IE)
Title: Cutting tools.
IPC: B23B27/14
Filed: 1970-03-05
Abstract: 1309634 Sintered carbide tools PRODUCTION TOOL ALLOY CO Ltd 5 March 1970 [10 March 1969] 12460/69 Headings C7A and C7D [Also in Division B3] A cutting tool has at least its cutting edge portion of a sintered composition consisting of at least one metallic carbide selected from vanadium, niobium, hafnium, zicronium, tungsten, titanium and tantalum carbides, the carbide being 70-95 per cent by weight of the total composition, and a metallic binder having its major part of ruthenium and possibly containing one or more of platinum palladium and rhodium, the said metal or metals forming 4-30 per cent by weight of the total composition. The binder may additionally contain one or more of iridium, osmium, nickel, cobalt and iron. Uncombined carbon may also be present up to 0À6 per cent by weight of the composition. When the metallic binder content is above 5% the composition may be made by ball milling in an organic solvent in a stainless steel mill, the constituents as metallic powders of particle size about 5 to 8 microns with high purity graphite. After milling the solvent is evaporated at low temperature and pressure and 2-4% paraffin wax is added as temporary binder. The composition is pressed at about 10 tons/square inch, presintered or dewaxed at 950C. under a reducing atmosphere and sintered under argon at 1 Torr at 1500C. to 1650C. for 1 hour. When the binder content is less than 5%, hot pressing at 1 to 2 tons/square inch in the above temperature range may be used.
[GB1309634A]
Patent IE-820428-L (IE)
Title: Process for the synthesis of isosorbide
IPC: C07D493/04
Filed: 1982-02-26
Abstract: The invention relates to the synthesis of isosorbide mononitrates. The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.
[US4381400A]
Patent IE-38987-L (IE)
Title: 1,2,4-triazole-3-carboxyamides as antiviral agents
IPC: C07D249/08
Filed: 1974-03-11
Abstract: 1427304 1,2,4 - Triazole - 3 - carboxamide and derivatives thereof ICN PHARMACEUTICALS Inc 11 March 1974 [12 March 1973] 10783/74 Heading C2C [Also in Division A5] 1 - # - D - Ribofuranosyl - 1,2,4 - triazole - 3- carboxamide is prepared by heating methyl 1,2,4 - triazole carboxylate with aqueous ammonia to yield 1,2,4 - triazole - 3 - carboxamide which is then reacted with the enzyme nucleoside phosphorylase to yield the desired product. The semihydrate of 1,2,4-triazole-3-carboxamide sodium salt is prepared by reacting the 1,2,4- triazole-3-carboxamide with sodium hydroxide. 1,2,4 - Triazole - 3 - thiocarboxamide is prepared by treating a mixture of triethyl orthoformate and 1-cyanoformimidic acid hydrazide with a solution of dioxane saturated with anhydrous hydrogen chloride to yield 3-cyano- 1,2,4-triazole which is then reacted with ethanol, triethylamine and hydrogen sulphide gas to yield the desired product.
[GB1427304A]
Patent IE-45035-L (IE)
Title: Imidazole derivatives
IPC: C07D233/54
Filed: 1977-04-26
Abstract: The imidazole compounds of the general formula II represent valuable intermediates for preparing pharmacologically active compounds. They are obtained by reacting a compound of the formula I in an organic solvent under basic conditions with a compound of formula R<2>-H. The symbols used in the general formulae I and II are defined in Claim 1. <IMAGE>
[GB1582865A]
Patent FI-803461-L (FI)
Inventor: HOLMWOOD GRAHAM
IPC: C07D239/26
Filed: 1980-11-05
Abstract: Pyrimidine-butanol derivatives of the general formula    <IMAGE>  (I) in which X represents hydrogen, halogen, alkyl or alkoxy, or represents benzyloxy which is optionally substituted by halogen and Y represents hydrogen or halogen have powerful growth-regulating properties.
Patent FI-831143-L (FI)
Inventor: GEST RENE
IPC: D01B5/14
Filed: 1983-04-05
Abstract: This invention relates to internal combustion burners. In the burners according to the invention, the combustible mixture flows in counter-current to the combustion gases while in contact with the same, and the introduction of the mixture into the combustion chamber is effected along a wall of said chamber and the emitted gases leave the chamber along a second wall thereof, the two walls being opposite one another. The burners according to the invention, which have improved performance and versatility of use, are of use more particularly for mineral fibre drawing processes.
Patent IE-32407-L (IE)
Title: Apparatus for coiling filament strands
IPC: B29D5/06
Filed: 1968-10-04
Abstract: 1,206,494. Sliding clasp fasteners. OPTIHOLDING A.G. 3 Oct., 1968 [8 Nov., 1967], No. 46954/68. Heading B5A. [Also in Division D1] Apparatus for coiling two filament strands into rows of interlocking elements for sliding clasp fasteners comprises a stationary mandrel 4, a guide bush 12 mounted to revolve planetwise about the axis of the mandrel, the bush having two filament guide holes 13, 14, means for preventing the bush from rotating about its own axis as it revolves about the mandrel, means for leading two filament strands individually from external bobbins to the holes 13, 14 and means for rotating the support about the mandrel. The filament strands may be provided with interlocking heads 22 as they pass through the bush. The bush may be prevented from rotating by planetary gearing or a fixed universal joint. In a further embodiment, a pair of mandrels and associated equipment are positioned side-by-side and the bushes are joined together by a fixed rod. The mandrel may be circular, elliptical or rectangular and may have a conical surface or oblique edges 23 leading to the portion where the coiling takes place. In a sequence of operation, the coiled filaments are flattened and heated and finally coiled. A double twist is imparted to the strands in each turn so that each strand crosses once over and once under the other strand.
[GB1206494A]
Patent IE-35726-L (IE)
Title: Preparing an enzyme composition in particulate form
IPC: C11D3/386
Filed: 1971-10-13
Abstract: 1324116 Spray producers KONINKLIJKE NEDERLANDSCHE GIST-EN SPIRITUSFABRIEK NV 13 Oct 1971 [14 Oct 1970] 48925/70 Heading B2F [Also in Divisions C3 and C5] Apparatus for preparing an enzyme composition in particulate form comprises a rotatable regularly spaced toothed disc 1 onto which a liquid composition comprising an enzyme and a binder are supplied, the resultant droplets formed by the teeth 4 being cooled in a tank (12), Fig. 5 (not shown). As shown, the liquid is supplied through a tube 10 onto a double walled trough 5 which has a weir 6 over the top of which the liquid flows and descends as a cylindrical curtain onto the disc 1 which is driven by a motor 3 via a shaft 2 at a pre-selected speed. The teeth 4 may be triangular as shown, be saw tooth in shape, or comprise radial elongate bars having rounded outer ends. The space between the walls 7, 9 may contain a beating fluid. The disc's upper surface may have channels to guide the liquid to the teeth 4.
[GB1324116A]
Patent IE-38190-L (IE)
Title: Diaza-oxa-bicyclodecane derivatives
IPC: C07D498/08
Filed: 1973-08-31
Abstract: Diaza-oxa-bicyclodecane derivatives of the formula:
[US3873526A]
Patent IE-901770-L (IE)
Title: Pharmaceutical Composition
IPC: A61K31/47
Filed: 1990-05-16
Abstract: Particulate nedocromil sodium with a mass median diameter of from 5 to 10 mu m is useful as a medicament for inhalation. The particulate nedocromil sodium of the invention is particularly advantageous in that its dispersion, ie the proportion of particles which are capable of penetrating deep into the lung, is substantially greater than the dispersion of conventional powders having smaller mass median diameters.
[EP0398631A1]
Patent IE-45965-L (IE)
Title: Aryl heterocyclic-w-pentano prostaglandins
IPC: A61K31/35
Filed: 1977-08-26
Abstract: Heterocyclo-omega- dioxopolyazamacrocycle to aryl. 
[FR2362848A1]
Patent IE-39568-L (IE)
Title: Plastics pipe socket.
IPC: B29C57/02
Filed: 1973-10-10
Abstract: An apparatus for forming a socket on a tube of a thermoplastic material, in which an upsetting movement is effected so that the socketed end is given a wall thickness which is at least equal to the wall thickness of the initial pipe. The apparatus comprises a mandrel, a two-part mold and a thrust member. An annular molding chamber is produced which has a radial dimension which is at least equal to the wall thickness of the pipe to be treated.
[US3893794A]
Patent IE-781985-L (IE)
Title: Piperazinopyrrolobenzodiazepines
IPC: A61P25/26
Filed: 1978-10-04
Abstract: 1. A 1,3,4,14b-tetrahydro-2H, 10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine of the general formula I see diagramm : EP0001585,P19,F1 wherein each of R1 , R3 and R4 is hydrogen or lower alkyl ; R2 is hydrogen, lower alkyl or higher alkyl, lower alkenyl, lower alkynyl, cycloalkyl or cycloalkenyl, each containing 3 to 7 ring members, or (cycloalkyl, hydroxy, amino, mono- or di-lower alkylamino, carboxy, lower carbalkoxy, carbamoyl, mono- or di-lower alkylcarbamoyl, HPh, lower alkanoyl or HPhCO)-lower alkyl ; Ph is 1,2-phenylene which can be substituted by at most two members selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halogen and trifluoromethyl ; C2 H2n is lower alkylene separating both nitrogen atoms by 2 or 3 carbon atoms and R5 is hydrogen, lower alkyl, carboxy, lower carbalkoxy or (hydroxy, amino, mono- or di-lower alkylamino)-lower alkyl ; the lower alkoxycarbonyl, lower or higher alkanoyl, adamantoyl, carbamoyl, mono- or di-lower alkylcarbamoyl derivates, cycloalkyl-carbonyl derivatives containing 3 to 7 ring members, or HPhCO-derivatives ; the 2-N-oxide, 2-lower alkyl or 2-HPh-lower alkyl quaternary ammonium derivatives and salts thereof.
[EP0001585A1]
Patent IE-812232-L (IE)
Title: Composition
IPC: A61P31/04
Filed: 1981-09-25
Abstract: A unit dose pharmaceutical composition suitable for oral administration which composition comprises a pharmaceutically acceptable carrier, a desiccant, amoxycillin trihydrate equivalent to 20 mg to 1500 mg of amoxycillin and potassium clavulanate equivalent to 20 mg to 500 mg of clavulanic acid, with the proviso that the weight ratio of amoxycillin to clavulanic acid is in the range 12:1 to 1:1; characterized in that the composition is in tablet form, wherein the desiccant is edible and incorporated within the tablets.
[US4537887A]
Patent IE-902236-L (IE)
Title: Disposable medicament inhalation device
IPC: A61J7/00
Filed: 1990-06-20
Abstract: A disposable device for the administration of powdered inhalation medicament is provided which comprises a rigid medicament reservoir (4) holding a unit dose of medicament (10) and having air inlet means (5,7) and medicament outlet means (8); and closure means (3) which are removable in use; wherein the medicament (10) held in the reservoir (4) is in loose powder form.
Patent IE-792238-L (IE)
Title: Two-layer complex
IPC: C09J7/35
Filed: 1979-11-23
Abstract: The invention relates to a two-layer composite material comprising a metal foil and an adhesive layer. The adhesive layer is formed of a mixture of two compounds A and B, compound A being a copolymer of an aliphatic monoolefin and a monoethylenically unsaturated carboxylic acid which has good adhesion for the metal foil and the container, and compound B being a compound adapted to reduce the adhesion of compound A for the metal foil and/or the container. Said composite material is intended in particular for the fabrication of caps serving as closures for containers.
[US4398644A]
Patent IE-40118-L (IE)
Title: Rodenticides
IPC: C07D/
Filed: 1974-11-14
Abstract: 1485804 Rodenticidal application of imidazopyridines ELI LILLY & CO 13 Nov 1974 [15 Nov 1973] 49052/74 Heading A5E A solid rodenticidal composition comprises a nutritive substance and/or an attractant and a fluoroalkyl substituted-1 H-imidazo (4, 5- b) pyridine of the formula: wherein R<SP>1</SP> is CF 3 , CF 2 Cl or CF 2 H; R<SP>2</SP> is H, OH or OR<SP>3</SP> wherein R<SP>3</SP> is a specified substituent; m, n, p and q are specified integers and R<SP>8</SP> is C 1 -C 7 perfluoroalkyl, CF 2 H or CF 2 . CF 2 H. The active ingredient may be used in amount to have a prompt toxic effect or to have a cumulative effect. Mixtures of the imidazopyridines may be used.
[GB1485804A]
Patent IE-40265-L (IE)
Title: Dispensing pump
IPC: B05B11/00
Filed: 1974-11-25
Abstract: An inexpensive, container mounted, plastic dispenser pump for dispensing a product from the container is leak-proof in its rest position since neither the outlet valve nor the atmospheric container vent open in response to container pressure or positional attitude of the dispenser. The outlet valve is positive in action since it is opened by relative movement of pump parts during actuation. The pump inlet valve is actuated by differential pressure. The atmospheric vent for the container is blocked by the position of pump parts when at rest.[US3949910A]
Patent IE-782565-L (IE)
Title: Imidazole derivatives
IPC: C07D233/64
Filed: 1978-12-28
Abstract: 4-Methyl-5-chloromethyl-imidazole is prepared in the form of its hydrochloride by direct chloromethylation of 4-methyl-imidazole, thus becoming readily available industrially as an intermediate.
[US4211875A]
Patent IE-43342-L (IE)
Title: Air conditioning system
IPC: F24F1/01
Filed: 1975-12-02
Abstract: 1519770 Air conditioning CASAIRE Ltd 25 Nov 1975 [2 Dec 1974] 52089/74 Heading F4V In a system for cooling a room space comprising a plurality of tubular venturi diffusers or mixing devices 10 arranged at high level in the space at intervals along insulated branch ducts 12, cold primary air supplied through main ducts 11 to the branch ducts 12 is injected into the inlet end of each venturi mixer 10 through one or more nozzles 30 so as to induce a flow of secondary air from the space, the resulting primary-secondary air mixture being discharged from the mixer into the space through one or more outlets 22. Primary air, which may comprise a mixture of fresh air and recirculated air, is passed through a filter 44 and a refrigeration unit 48 containing a cooling coil 46, the cold primary air leaving the unit being conveyed through the ducts 11 and 12 to the nozzles 30 with the aid of a centrifugal fan 42. The proportion of fresh air to recirculated air can be controlled by means of dampers 54 and 56. Each tubular venturi mixer 10 has a rectangular cross-sectional shape and is provided with a bell-shaped inlet opening 20 at one end and one or more outlets 22 at the other end. The venturi mixers 10 may be mounted horizontally as shown, or vertically (see Figs. 2c and 2d).
[GB1519770A]
Patent NO-750461-L (NO)
Inventor: RAUCH K
IPC: C07C67/00
Filed: 1975-02-12
Abstract: Fremgangsmåte til fremstilling av maursyre.
Patent NO-803201-L (NO)
Title: Apparat for emballering av varer, saerlig en sammenpresset stabel isolasjonsmatter, i en pose eller sekk
Inventor: JOHANSEN TAGE LUND
IPC: B65B43/30
Filed: 1980-10-27
Abstract: I at apparat for emballering av særlig en sammenpresset stabel mineralullmatter (23) i en pose eller sekk (9) er det med henblikk på reduksjon av behovet for manuell arbeids-kraft anordnet en helautomatisk mekanisme for åpning av de flatlagte poser og innføring av disse på et pakkenebb (19), gjennom hvilket varen kan skyves til bunns i posen. Denne mekanisme har et par holdere (6, 7) med gripere (13) for midlertidig ftg av den flatlagte pose (9) og ut-spiling av dennes åpne ende ved økning av avstanden mellom holderne, samt for innskyvning av posen på pakkenebbet (19). Samtidig med at denne pose fylles kan en neste pose mottas av holderne, for å være klar til fylling så snart den første pose er fjernet fra pakkenebbet.
Patent NO-803411-L (NO)
Inventor: BRITTAIN DAVID ROBERT
IPC: A61K31/00
Filed: 1980-11-12
Abstract: The invention concerns novel 1'-substituted spiro[imidazolidine-4,3'-indoline]-2,2',5-triones of the formula: <IMAGE> I  in which R1 is (1-12C)alkyl; phenyl, naphthylmethyl or cinnamyl optionally bearing 1-2 halogeno substituents; or benzyl optionally bearing 1-3 substituents independently selected from halogeno, trifluoromethyl, (1-4C)-alkyl, (1-4C)alkoxy, nitro, cyano and hydroxy; and ring A optionally bears one substituent selected from halogeno, (1-4C)alkyl, (1-4C)alkoxy, nitro and hydroxy, or two substituents independently selected from halogeno (1-4C)alkyl and nitro; or a pharmaceutically acceptable salt thereof; but excluding those compounds wherein R1 is methyl, ethyl, n-propyl or unsubstituted benzyl and benzene ring A is unsubstituted. The compounds of the invention are potent inhibitors of the enzyme aldose reductase and are of use in the treatment or prophylaxis of certain complications of diabetes or galactosemia. The invention also embraces processes for the manufacture of the novel compounds of formula I, as well as pharmaceutical compositions of such compounds. A representative compound is 1'-(2-fluoro-4-bromobenzyl)-spiro]imidazolidine-4,3'-indoline]-2,2',5- trione.
Patent NO-820554-L (NO)
Inventor: GUIDO HEINZ
IPC: H05B7/06
Filed: 1982-02-23
Abstract: An electric furnace or electric arc or resistance melting furnaces comprises a housing with a refractory lining which defines a furnace hearth in the housing and with a plurality of electrodes extending through the refractory having one of their ends terminating in the hearth and the opposite ends extending out of the housing. A plate is arranged in spaced relationship to the housing on its exterior and is connected to the opposite ends of the electrodes. The plate is arranged to define a cooling space outside of the housing which surrounds the electrodes. A cooling fluid is circulated into the cooling space and over the electrodes.
Patent NO-821557-L (NO)
Inventor: BRITTAIN DAVID ROBERT
IPC: C07D487/10
Filed: 1982-05-11
Abstract: The invention provides a pharmaceutical composition comprising an aldose reductase inhibitory 1'-substituted-spiro[pyrrolidine-3,3'-indoline]-2,2', 5-trione of the formula:wherein Ra is (2-7 C) alkyl or (3-7 C) alkenyl, naphthylmethyl or cinnamyl optionally bearing one or two halogeno nuclear substituents, or Ra is benzyl optionally bearing one or two sub- stltuents and benzene ring A optionally bears one or two substituents, trifluoromethyl and nitro; or a salt thereof with a base affording a pharmaceutically acceptable cation; or a non-toxic, biodegradable precursor thereof; together with a pharmaceutically a-ceptable diluent or carrier. The invention also provides novel compounds of formula I and processes for their manufacture.The compositions are of application in the treatment or prophylaxis of the side effects of diabetes or galactosemia.
Patent NO-883100-L (NO)
Inventor: CONNOR DAVID THOMAS
IPC: A61P1/04
Filed: 1988-07-12
Abstract: Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.
Patent NO-885739-L (NO)
Inventor: SCHOLTHOLT HANS
IPC: H01R4/48
Filed: 1988-12-23
Abstract: The U-shaped bent contact member (1) has insulation-perforating terminals on the ends of the side limbs for connection to incoming and outgoing connecting wires (2). Two contact springs (5) are torn off in the manner of fins from the base of the contact member (1) along its longitudinal edges, from the opposite direction, and are bent in the direction of the side limbs. The contact springs form a contact point for the connection of a protection plug. <IMAGE>
Patent NO-891694-L (NO)
Inventor: ROTHER DIETRICH
IPC: H03D1/22
Filed: 1989-04-25
Abstract: A quadrature receiver is disclosed which contains two mixers (M1, M3) in an in-phase receiving path and two mixers (M2, M4) in a quadrature receiving path for converting a received signal to a low IF. Each of the mixers is fed with an oscillator signal (O1 through O4), with the oscillator signal fed to one mixer of the respective receiving path having alternately the same or opposite phase from that of the oscillator signal fed to the other mixer of the same receiving path. In each receiving path, the mixers are followed by a circuit (P', P'') which delivers an in-phase signal and a quadrature signal, respectively. These circuits compensate for the DC offset caused by the mixers.
Patent NO-895028-L (NO)
Inventor: PURCHIO ANTHONY F
IPC: A61K38/00
Filed: 1989-12-14
Abstract: The present invention relates to a chimeric transforming growth factor- beta 1/ beta 2 comprising the amino acid sequence substantially as depicted in FIG. 1 from about amino acid number 279 to about amino acid residue number 390, and to the production by recombinant DNA methods.