Patent SG-11201807548S-A (SG)
Title: Inducible binding proteins and methods of use
Inventor: BAEUERLE PATRICK
IPC: C07K16/30
Filed: 2017-03-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 0101111101110111011011010111 10111110H III International Bureau .. .... ..Yejd (10) International Publication Number ..... .....!;,,, (43) International Publication Date WO 2017/156178 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) C07K 16/30 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 16/18 (2006.01) A61K 39/395 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/021435 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 8 March 2017 (08.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/305,092 8 March 2016 (08.03.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: MAVERICK THERAPEUTICS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 3260 B Bayshore Blvd., 1st Floor, Brisbane, CA TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 94005 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — (72) Inventors: BAEUERLE, Patrick; Waldpromenade 18c, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, L 82131 Gauting (DE). DUBRIDGE, Robert, B.; 825 Holly V, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Road, Belmont, CA 94002 (US). WESCHE, Holger; 1080 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Jamestown Avenue, San Francisco, CA 94124 (US). EVN- — IN, Luke; 768 El Camino Del Mar, San Francisco, CA Declarations under Rule 4.17: 94121 (US). GUENOT, Jeanmarie; 45 Juniper Street, #3, — as to applicant's entitlement to apply for and be granted a San Francisco, CA 94103 (US). PANCHAL, Anand; 2615 patent (Rule 4.1700) Turk Street, Apt A., San Francisco, CA 94118 (US). VINOGRADOVA, Maia; 2079 Ascot Drive, Unit 240, — as to the applicant's entitlement to claim the priority of the = Moraga, CA 94556 (US). earlier application (Rule 4. 1 7(iii)) Agents: MANN, Jeffry S. et al.; Morgan, Lewis & Bocki- Published: (74) us LLP, One Market Spear Street Tower, San Francisco, _ with international search report (Art. 21(3)) CA 94105 (US). = — = = Title: INDUCIBLE BINDING PROTEINS AND METHODS OF USE (54) FIG. 3 = = anti-CD3 anti-EGFR = = sePv 7 Ab C — EK Cleavable Linkers = — anti-CD3 . 4 :, •- '''. e, scFv 1 'Zt Proteolytk ' ss ‘ ,..,_ ''''' Cleavage — ''', E by EK : a nti-EGFR — \\, G8 sdAb vi .4 ail .1 N GC IN Il Cancer Cell ,tD 11 in ,—, IN 1-1 (57) : Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to 0 CD3, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are \" h p armaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such poly- peptide constructs. Also disclosed are methods of using the disclosed polypeptide constructs in the prevention, and/or treatment dis - .• eases, conditions and disorders.