baber/WOPTO huggingface dataset:
Patent AU-2006319358-B2 (AU)
Title: Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
Inventor: BARGHORN STEFAN
IPC: A61K38/04
Filed: 2006-11-30
Granted: 2012-01-19
Abstract: Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.
Patent AU-2007241815-B2 (AU)
Title: Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation
Inventor: KAMISHITA TAIZOU
IPC: A61K9/12
Filed: 2007-04-20
Granted: 2012-08-16
Abstract: Disclosed is a sprayable gel-type skin/mucosa-adhesive preparation comprising a gel preparation. The gel preparation comprises a gel base material containing a skin/mucosa adhesive agent and a pharmaceutical active substance contained in the gel base material. Also disclosed is an administration system using the preparation.
Patent AU-2007254667-B2 (AU)
Title: Tinnitus Rehabilitation Device and Method
Inventor: BENJAMIN DAVIS PAUL
IPC: A61B5/12
Filed: 2007-12-21
Granted: 2011-12-08
Abstract: A tinnitus method and device for providing relief to a person suffering from the disturbing effects of tinnitus is described. The method can be implemented entirely in software to spectrally modify an audio signal in accordance with a predetermined masking algorithm which modifies the intensity of the audio signal at selected frequencies. A predetermined masking algorithm is described'which provides intermittent masking of the tinnitus wherein, at a comfortable listening level, during peaks of the audio signal the tinnitus is completely obscured, whereas during troughs the perception of the tinnitus occasionally emerges. In practice it has been found that such intermittent masking provides an immediate sense of relief, control and relaxation for the person,*whilst enabling sufficient perception of the tinnitus for habituation and long term treatment to occur. Advantageously the predetermined masking algorithm is specifically tailored to the audiometric configuration of the person. For example, the masking algorithm may be partly tailored to the hearing loss characteristic of the person. A tinnitus rehabilitation device used in conjunction with a personal sound reproducing system is also described. PEAK MUSIC SPECTRA HEARING LOSS 4 R HTL (SPL) 40 x L HTL (SPL) a R WTRP + L WTRP FREQ (Hz)
Patent AU-2007282400-B2 (AU)
Title: Pharmaceutical composition
Inventor: NONOMURA MUNEO
IPC: A61K47/38
Filed: 2007-08-09
Granted: 2012-08-30
Abstract: Disclosed is a solid pharmaceutical composition containing a low-melting-point oil/fat-like substance, which is improved in drug eluting property and has excellent stability and dissolution property. Specifically, disclosed is a solid pharmaceutical composition comprising a pharmacologically active ingredient, a low-melting-point oil/fat-like substance and a low-viscosity binder. Also disclosed is a method for improving the elution of a pharmacologically active ingredient from a solid pharmaceutical composition comprising the pharmacologically active ingredient and a low-melting-point oil/fat-like substance, characterized by using a low-viscosity binder.
Patent AU-2007290858-B2 (AU)
Title: Silicon production with a fluidized bed reactor integrated into a Siemens-type process
Inventor: MOLNAR MICHAEL
IPC: C01B33/03
Filed: 2007-06-14
Granted: 2012-12-13
Abstract: A fluidized bed reactor and a Siemens reactor are used to produce polycrystalline silicon. The process includes feeding the vent gas from the Siemens reactor as a feed gas to the fluidized bed reactor.
Patent AU-2007327150-B2 (AU)
Title: Screening method using sample adsorption on filter paper
Inventor: SKOGSTRAND KRISTIN
IPC: G01N33/50
Filed: 2007-11-30
Granted: 2012-07-12
Abstract: The present invention discloses a diagnostic test and method comprising mixing blood or another biological fluid sample with' a test compound and spotting the blood or the biological fluid on filter paper for subsequent analysis of the effect of the test compound on the blood or on the biological fluid. The biological fluid can be a cerebrospinal fluid, a peritoneal fluid, a cyst fluid, an amniotic fluid, a lavage fluid, a saliva, a. cell extract or a tissue extract. The test compound is chosen among an amino acid, a peptide, a protein, a carbohydrate, an oligosaccharide, a polysaccharide, a glycoprotein, a lipid, a lipoprotein, a glycosa- minoglycan, a hormone, a steroid, a vitamin, a low molecular weight synthetic or natural compound which influences the blood or the biological fluid to cause an alteration of its composition e.g. a toxin, allergen, autoantigen, bacterial protein or polysaccharide, viral protein, fungal protein or polysaccharide, parasitic protein or polysaccharide, bacterial lipopolysaccharide or any other compound relevant to diseases.
Patent AU-2008202806-B2 (AU)
Title: Polymeric films
Inventor: GUO HAILAN
IPC: C08L33/08
Filed: 2008-06-25
Granted: 2013-04-04
Abstract: A melt processed film comprising a polymer having several acrylic components.
Patent AU-2008207516-B2 (AU)
Title: Power tool
Inventor: RICHARDS GARETH
IPC: B23D51/01
Filed: 2008-08-25
Granted: 2010-07-29
Abstract: A power tool (10) comprises a main body (12) having a motor driven tool (24) extending from a first front end of the main body, and has a first handle (18) integrally formed on the main body to be remote from this front end. A second support handle (20) is pivotally mounted on the tool body (12) to be pivotally displaceable about a pivot axis (34) so as to be displaceable from a first position in which a grip (22) of the support handle is disposed forwards of the first handle (18), to a second position wherein the grip member (22) is disposed rearwardly of the first handle (18).  Also disclosed is the use of restraining means engageable between the support handle (20) and the main body (12) for releasably restraining the handle in either of the first or second positions. Further disclosed is a dual switching mechanism requiring operation of a switch on the main handle (18) and also on the grip (22) of the support handle (20) to allow operation of the tool, irrespective of whether the handle (20) is in its first or second position.
Patent AU-2008207699-B2 (AU)
Title: Seat routine processes
Inventor: STIRLEN WILLIAM CHRISTOPHER
IPC: G06F17/30
Filed: 2008-09-03
Granted: 2013-02-21
Abstract: The subject matter of this specification can be embodied in, among other things, a process that includes selecting accommodations during a travel reservation is described. The method includes receiving, at a software application 5 that manages travel reservations, input that customizes configurable attributes of software travel objects representing accommodations used in transportation of passengers. The method also includes receiving criteria from a customer specifying preferences that affect a passenger's experience during travel, ranking the received criteria so that one or more criterion are preferred, selecting one or 1o more of the accommodations using an optimization function to compare the ranked criteria to the customized configurable attributes, and outputting the selected one or more accommodations for use by the customer in selecting a first accommodation for the passenger. 30 Start Receive values for configurable properties from I- carrier employee J130 Dynamically update configurable properties for travel accommodationgoga Transmit configurable properties to user for user selection of an accommodation 306 Receive selection from user of desired properties for the accommodation Receive associated ranking with each selected property : End
Patent AU-2008221113-B2 (AU)
Title: Drilling tool with feed control
Inventor: ANDERSEN THOMAS SUNE
IPC: E21B17/07
Filed: 2008-02-28
Granted: 2013-05-02
Abstract: The present invention relates to a drilling tool (1) for drilling downhole, comprising a drilling head (2) in connection with a first portion (18) of the drilling tool, a driving unit (9) for driving the drilling head and the first portion forward in a longitudinal movement while drilling, and a feed control (19) for controlling the longitudinal movement of the drilling head.
Patent AU-2008267734-B2 (AU)
Title: Methods of modifying antibodies, and modified antibodies with improved functional properties
Inventor: URECH DAVID
IPC: A61K39/395
Filed: 2008-06-25
Granted: 2014-07-24
Abstract: The invention provides methods of using sequence based analysis and rational strategies to modify and improve the structural and biophysical properties of immunobinders, and in particular of single chain antibodies (scFvs), including such properties as stability, solubility, and/or antigen binding affinity. The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions at amino acid positions identified by analysis of a database of selected, stable scFv sequences, wherein preferred amino acid residues for substitution have been identified. The invention also provides immunobinders prepared according to the engineering methods of the invention. The invention also provides preferred scFv framework scaffolds, into which CDR sequences can be inserted, as well as scFv antibodies made using these preferred framework scaffolds.
Patent AU-2008269531-B2 (AU)
Title: Industrial method for the synthesis of 17-acetoxy-11beta-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
Inventor: TUBA ZOLTAN
IPC: C07J21/00
Filed: 2008-06-19
Granted: 2013-07-04
Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(l l)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones. The process according to the invention is the following: i) formation of an epoxide on the double bond in position 5(10) of 3,3-[l,2-ethandiyl- bis(oxy)]-oestr-5(10),9(l l)-dien-17-one of formula (II) with hydrogen peroxide; ii) addition of hydrogen cyanide formed in situ on position 17 of the obtained 5,10α- epoxy-3,3-[l,2-ethandiyl-bis(oxy)]-5α-oestr-9(l l)-en-17-one of formula (III); iii) silylation of the hydroxyl group in position 17 of the formed 5,10α-epoxy-3,3-[l,2- ethandiyl-bis(oxy)]-17α-hydroxy-5α-oestr-9(l l)-en-17β-carbonitrile of formula (IV) with trimethyl chlorosilane; iv) reacting the obtained 5,10α-epoxy-3,3-[l,2-ethandiyl-bis(oxy)]-17-[trimethyl-silyl-oxy]-5α-oestr-9(l l)-en-17β-carbonitrile of formula (V) with 4-(dimethylamino)-phenyl magnesium bromide Grignard reagent in the presence of CuCl (Teutsch reaction); v) silylation of the hydroxyl group in position 5 of the formed l lβ-[4-(dimethyl-amino)-phenyl] -3,3 - [1,2-ethandiyl-bis(oxy)] -5 -hydroxy- 17α- [trimethylsilyl-(oxy)] -5 α-oestr-9-en-17β-carbonitrile of formula (VI) with trimethyl chlorosilane; vi) reacting the obtained llβ-[4-(dimethylamino)-phenyl]-3,3-[l,2-ethandiyl-bis(oxy)]-5,17α-bis-[trimethyl-silyl-(oxy)]-5α-oestr-9-en-17β-carbonitrile of formula (VII) with diisobutyl aluminum hydride and after addition of acid to the reaction mixture; vii) methoxy-methylation of the obtained l lβ-[4-(dimethylamino)-phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5, 17α-bis-[trimethyl-silyl-(oxy)]-5α-oestr-9-en-17β-carbaldehide of formula (VIII) with methoxy-methyl Grignard reagent formed in situ, while hydrolyzing the trimethylsilyl protective groups; viii) oxidation of the hydroxyl group in position 20 of the obtained 17,20ξ-dihydroxy-11β-[4-(dimemylarnino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one of formula (IX) with dicyclohexyl carbodiimide in the presence of dimethyl sulfoxide and a strong organic acid (Swern oxidation), and in given case after purification by chromatography; ix) acetylation of the hydroxyl group in position 17 of the obtained 11β-[4-(dimethylamino)-phenyl] -17-hydroxy-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (X) with acetic anhydride in the presence of perchloric acid, and in given case the obtained 7-acetoxy-11β-[4-(dimethylamino)-phenyl)]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I) is purified by chromatography. The invention also relates to the new intermediates of formula (VII) and (VIII).
Patent AU-2008320753-B2 (AU)
Title: Turbine engine with transverse-flow hydraulic turbines having reduced total lift force
Inventor: TOURABI ALI
IPC: F03B13/00
Filed: 2008-10-23
Granted: 2012-09-20
Abstract: The invention relates to a turbine engine (55) that includes at least first and second lift turbine stacks (53A, 53B) with transverse flow. The shafts of adjacent turbines in the first stack are connected by a first coupling device adapted for compensating space misalignments, and the shafts of adjacent turbines in the first stack are connected by a second coupling device adapted for compensating for space misalignments. The turbine engine includes a device (46, 48) for supporting the first and second turbine stacks, which is symmetrical to said plane, and a control device (220A, 220B, 224) adapted for permanently maintaining the symmetry between the first and second turbine stacks relative to the plane, and for maintaining the rotation speeds of the first and second turbine stacks at equal values in opposite rotation directions.
Patent AU-2008331309-B2 (AU)
Title: Sensing system and method
Inventor: JAIN KARISHMA
IPC: G01M5/00
Filed: 2008-11-28
Granted: 2014-05-29
Abstract: A sensing system comprises a material having a matrix structure in which a plurality of sensing elements are embedded, the sensing elements having electron distribution and/or transport properties that change in response to a change in a physical or chemical property of the material. The sensing system further comprises a receiver, including an antenna, the receiver arranged to receive a source RF signal and a returned RF signal, the returned RF signal being received from the material. A change in the electron distribution and/or transport properties of the sensing elements cause the source RF signal to change, such that a change in a property of the material can be determined from the returned RF signal. A corresponding method of sensing a change in a property of a material is also provided.
Patent AU-2009201474-B2 (AU)
Title: An actuator with a main rod and an auxiliary rod
Inventor: LIEGEOIS PIERRE-YVES
IPC: F16F9/24
Filed: 2009-04-15
Granted: 2013-06-06
Abstract: -9 The invention relates to a telescopic actuator comprising a cylinder (1) in which a main rod (2) is mounted to slide telescopically along a sliding axis (X) 5 between a retracted position and an extended position, the telescopic actuator including an auxiliary rod mounted to slide telescopically in the main rod along said sliding axis between a retracted position and an extended position, the actuator including controlled retaining means (30, 31, 32, 33) for retaining the auxiliary rod in the retracted position inside the main rod, the actuator further including brake means 10 for braking sliding of the auxiliary rod in the main rod in the extension direction. According to the invention, the auxiliary rod (20) has a thread (101) on an outside surface, the main rod (2) carrying at its end a rotary bearing (102) that centers the auxiliary rod inside the main rod and that co-operates via a reversible helical connection with the thread of the auxiliary rod such that extension of the auxiliary 15 rod causes the rotary bearing to rotate, the brake means (106, 110) being arranged to brake rotation of the rotary bearing during extension of the auxiliary rod. 09/04/09,va 17884 speci,9
Patent AU-2009201584-B2 (AU)
Title: Vacuum cleaner control system
Inventor: LOVELASS SHAUN
IPC: A47L5/30
Filed: 2009-04-21
Granted: 2014-03-13
Abstract: The present invention provides a vacuum cleaner control system comprising: a first user-operable control (30) for switching a suction source (14) of said vacuum cleaner between an on condition and an off condition; a second user-operable control (32) for switching a rotatable brush (24) in a floorhead (22) of said vacuum cleaner 5 between an on condition and an off condition; a third user-operable control (34) for switching a filter cleaning mechanism (20) for cleaning a filter (18) of said vacuum cleaner between an on condition and an off condition; a detector (38) for detecting when a handle (12) of said vacuum cleaner is tilted between a substantially vertical, storage position and an angled, use position; and an electronic circuit (40) for 10 receiving input signals from said first, second and third user-operable controls (30, 32, 34) and from said detector (38), said electronic circuit (40) having a first output for switching said suction source on and off, a second output for switching said floorhead brush on and off and a third output for switching said filter cleaning mechanism on and off. In a preferred embodiment, the vacuum cleaner control system further 15 comprises a display (36), and the electronic circuit (40) further comprises an output for driving said display, and said display comprises an input for receiving said output from said electronic circuit. [Fig. 2] 36 30,32,34 42 26 FIG.1
Patent AU-2009206113-B2 (AU)
Title: Method for the beneficiation of coal
Inventor: KENNEDY DENNIS
IPC: B03D103/08
Filed: 2009-01-15
Granted: 2013-09-05
Abstract: The present invention relates to the beneficiation of coal by the process of froth flotation and specifically relates to a process for the froth flotation of coal using a mixture of fatty acids and rosin acids (and/or certain derivatives of fatty acids and rosin acids) as a collector.
Patent AU-2009222589-B2 (AU)
Title: Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
Inventor: ROGER AOKI KEI
IPC: C07K14/16
Filed: 2009-10-02
Granted: 2011-12-22
Abstract: CELL-BASED FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) ASSAYS FOR CLOSTRIDIAL TOXINS Abstract The present invention provides a method of determining 5 clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum - of the donor fluorophore; and a clostridial toxin recognition sequence 10 containing a cleavage site that intervenes between the donor fluorophore and the acceptor, where resonance energy transfer is exhibited between the donor fluorophore and the acceptor under the appropriate conditions; (b) exciting the donor fluorophore; and (c) determining resonance energy 15 transfer of the contacted cell relative to a control cell, where a difference in resonance energy transfer of the contacted cell as compared to the control cell is indicative of clostridial toxin activity.
Patent AU-2009257987-B2 (AU)
Title: Expandable cage
Inventor: STRAUSS KEVIN R
IPC: A61B17/70
Filed: 2009-03-30
Granted: 2014-04-03
Abstract: An apparatus supports the spine between vertebrae and promotes spinal fusion. The apparatus generally includes a first supporting member, a second support member, and an expansion member. The first support member has a first longitudinal passage extending therethrough, a first supporting end configured to engage tissue, and a rack configured to engage a tool. The second supporting member contains a second longitudinal passage extending therethrough and a second supporting end configured to engage tissue. The second longitudinal passage is dimensioned to receive at least a portion of the first supporting member. The first and second supporting members are configured to move with respect to each other. The expansion member is removably positioned between the first and second supporting members and is adapted to maintain the first and second supporting members in a fixed relative position.
Patent AU-2009261783-B2 (AU)
Title: Phenyl-alkyl piperazines having a modulating activity of TNF
Inventor: BARONI MARCO
IPC: A61K31/495
Filed: 2009-06-16
Granted: 2014-08-07
Abstract: The present invention relates to novel phenyl-alkyl piperazines having a modulating activity of TNF, to the pharmaceutical compositions containing same, and to a method for the preparation thereof.
Patent AU-2009296023-B2 (AU)
Title: Acidified nutritional formula
Inventor: KREB NICO
IPC: A23L33/00
Filed: 2009-09-10
Granted: 2015-01-22
Abstract: A nutritional formulahas a pH in the liquid state in the range from 4.8 to 5.2, which formula comprises, on a dry matter basis, lactic acid in an amount of not more than 1.35% and at least 0.5% of a salt of lactic acid (+)-lactic acid for preparing nutritional formulas with a pH in the range of 3.5 to 6.
Patent AU-2009334570-B2 (AU)
Title: Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof
Inventor: ALTENBURGER JEAN-MICHEL
IPC: C07D405/12
Filed: 2009-12-24
Granted: 2016-06-09
Abstract: The invention relates to compounds with the formula (I), in a basic state or as an acid addition salt: (I) where n is equal to 0, 1, 2, 3 or 4; m is equal to 0, 1 or 2; o is equal to 0 or 1; X is a -CH
Patent AU-2009351092-B2 (AU)
Title: Methods for enhancing the production and consumer traits of plants
Inventor: LONG BRYANT JEROME
IPC: A01H1/04
Filed: 2009-08-12
Granted: 2015-06-04
Abstract: The invention provides methods for producing plants, plant materials and seeds that receive multiple desirable attributes for consumers of these products, as well as for commercial plant growers, and to improved plants, plant materials and seeds that are produced by these methods. These inventive methods provide hybrid plants, plant materials and seeds having the mutant shrunken-2i (sh2-i) allele incorporated into their genomes sequentially along with one or more other mutant alleles, such as the sugary- 1 (su1), sugary enhancer- 1 (se1) and/or shrunken-2 (sh2) alleles, and that have multiple beneficial traits, including an extended sugar retention ability at the post prime eating stage and a significantly enhanced vigor and fitness to the plant, plant material and/or seed during seed germination, seedling emergence from soil, and plant development.
Patent AU-2010203130-B2 (AU)
Title: Wind turbine power module mounted on the tower foundation
Inventor: WOBBEN ALOYS
IPC: F03D9/25
Filed: 2010-07-22
Granted: 2013-09-12
Abstract: A Method for constructing a wind power plant with a tower which is set on a foundation as well as at least one electric power module which essentially consists of a transformer and/or an inverter and/or another electrical device for controlling the wind power plant and/or for conducting the electric power furnished by the generator of the wind power plant and fed into a network, wherein the power module is put on to the tower foundation before construction of the tower. Fig. 4