baber/WOPTO huggingface dataset:
Patent WO-2022071944-A1 (WO)
Title: Network-connected toy wand system with levitation-inducing cradle
Inventor: KAUFFMANN ALEJANDRO
IPC: H02N15/00
Filed: 2020-09-30
Abstract: Systems and devices for levitating interactive objects are provided. A toy wand system can include a toy wand and a cradle. The toy wand can include a shaft portion having at least one magnetically-reactive element inside and a handle. The cradle can be configured to receive and hold the toy wand. The cradle can include a body that is shaped to form an opening therethrough sufficient to accommodate the shaft portion, a solenoid coil formed proximate the opening, electrical circuitry configured to cause an electrical current to flow in the solenoid coil, wireless communication circuitry; and a controller coupled to the wireless communication circuitry and the electrical circuitry and configured to control the timing and amount of electrical current flowing through the solenoid coil to cause levitation or levitation-like movement of the toy wand within said opening by virtue of electromagnetic interaction with the magnetically-reactive element of the shaft portion.
Patent WO-2021071772-A1 (WO)
Title: Multi-agent simulations
Inventor: WHITE BRANDYN ALLEN
IPC: G06N3/00
Filed: 2020-10-05
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating a simulation of an environment that is being interacted with by a plurality of agents over a plurality of time steps, wherein the simulation comprises a respective simulation state for each time step that specifies a respective state of each agent at the time step. In one aspect, a method comprises, for each time step: obtaining a current simulation state for the current time step; generating a plurality of candidate next simulation states for a next time step; determining, for each candidate next simulation state, a discriminative score characterizing a likelihood that the candidate next simulation state is a realistic simulation state; and selecting a candidate next simulation state as the simulation state for the next time step based on the discriminative scores for the candidate next simulation states.
Patent WO-2022086487-A1 (WO)
Inventor: OTTEN ERIK
IPC: G06G7/66
Filed: 2020-10-19
Abstract: Un système de commande de véhicule comprend une pluralité de capteurs de hauteur de conduite, un système de freinage et un dispositif de commande. Les capteurs de hauteur de conduite peuvent déterminer des informations de hauteur de conduite associées à des roues individuelles d'un véhicule. Le système de freinage peut appliquer une force de freinage aux roues individuelles du véhicule en réponse à la fourniture d'un signal d'application de freinage. Le dispositif de commande peut générer le signal d'application de freinage pendant le tangage du véhicule sur la base de la vitesse du véhicule et des informations de hauteur de conduite.
Patent WO-2021081234-A1 (WO)
Title: Fluid introducer for a piping system
Inventor: BALMAN JAMES
IPC: F28G9/00
Filed: 2020-10-22
Abstract: The present disclosure provides a fluid introducer for a piping system that includes first and second piping sections. The fluid introducer provides a direct connection to the first piping section through a separator body configured to be positioned in an expansion gap between the first piping section and the second piping section such that a first end face of the separator body faces the first piping section and a second end face of the separator body faces the second piping section. The fluid introducer is configured to direct fluid from the fluid source through fluid introduction passaging into the first piping section and block the fluid from flowing into the second piping section.
Patent WO-2021091888-A1 (WO)
Title: User interface based in part on eye movement
Inventor: YUDANOV DMITRI
IPC: G06F3/14
Filed: 2020-11-03
Abstract: An apparatus having a wearable structure, a computing device, a display, and a camera. The wearable structure is to be worn by a user and connected to the computing device, the display, and/or the camera. The computing device can be connected to the wearable structure, the display, and/or the camera. The display can be connected to the wearable structure, the computing device, and/or the camera. The display is to provide a graphical user interface (GUI). The camera can be connected to the computing device, the wearable structure, and/or the display. The camera is to capture eye movement of the user. A processor in the computing device is to identify one or more eye gestures from the captured eye movement. The processor is to control one or more parameters of the display and/or the GUI based on the identified eye gesture.
Patent WO-2021091906-A1 (WO)
Inventor: AGARWAL SURESH
IPC: C07K16/28
Filed: 2020-11-03
Abstract: The present invention relates to treatment methods for leukemia using bispecific antibody constructs that specifically bind to human CD33 and human CD3. In particular, the present invention relates to methods for treating myeloid leukemia, including relapsed/refractory myeloid leukemia, in a patient in need thereof comprising administering to the patient at least one initiation cycle and at least one maintenance cycle of an anti-CD33 x anti-CD3 bispecific antibody construct, wherein each initiation cycle and maintenance cycle comprises administering the bispecific antibody construct according to specific dosage regimens. Pharmaceutical compositions comprising the bispecific antibody constructs for use in the methods are also disclosed.
Patent WO-2021092070-A1 (WO)
Title: Somatic variant calling from an unmatched biological sample
Inventor: JONGENEEL PATRICK
IPC: C12Q1/68
Filed: 2020-11-04
Abstract: Methods for somatic variant calling from an unmatched biological samples is provided. The method can include obtaining nucleic acid sequence data corresponding to a biological sample of a subject. The method can also include aligning the nucleic acid sequence data to a reference genome. The method can also include identifying, based on the aligned nucleic acid sequence data, a set of candidate variants in said nucleic acid sequence data. The set of candidate variants may include one or more somatic variants and one or more germline variants. The method can also include, without using a nucleic acid sequencing data from a matching biological sample of the subject, processing the set of candidate variants using a trained machine-learning model to identify the somatic variants. The method can also include outputting a report that identifies the somatic variants.
Patent WO-2021092530-A1 (WO)
Title: Canne roulante
Inventor: ROCK RHONDA G
IPC: A61H3/04
Filed: 2020-11-08
Abstract: Un dispositif d'aide à la marche à une main comprend une poignée et une pluralité de pieds fixés à un cadre de support de forme variable, présentant divers modes de réalisation indépendants comprenant une orientation trapézoïdale de mode de réalisation entre les pieds avant et arrière, et une orientation d'appareil de mode de réalisation qui est inclinée vers l'arrière. L'invention concerne également toute une gamme de compartiments de stockage/transport.
Patent WO-2021101836-A1 (WO)
Inventor: MCCAULEY JOHN
IPC: C07D215/52
Filed: 2020-11-16
Abstract: The present invention provides methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for the possible inhibition of plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating a  Plasmodium  infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
Patent WO-2021126638-A1 (WO)
Title: Resorbable implants for reconstruction of bone defects
Inventor: SARIIBRAHIMOGLU KEMAL
IPC: A61F2/28
Filed: 2020-12-09
Abstract: Devices (200) to repair bone defects prevent the formation of depressions and palpable tissue at bone repair sites. The devices can be used to repair burr holes in the cranium, providing an improved cosmetic result that reduces or eliminates functional handicaps that can result from combing and hairdressing. The devices are secured in bone defects with filament elements (210), by expanding the device inside the bone defect, or by gluing. Tissue in-growth into the device regenerates bone at the defect site, and prevents the formation of depressions or palpable tissue. The devices preferably comprise a ceramic and poly-4-hydroxybutyrate or copolymer thereof, or a ceramic and poly (butylene succinate) or copolymer thereof.
Patent WO-2021138050-A1 (WO)
Title: Dynamic integration checklist for development platform
Inventor: NALEPA LESIA
IPC: G06F8/60
Filed: 2020-12-16
Abstract: Generally discussed herein are devices, systems, and methods for guiding a user through a cloud application creation or deployment process using a development platform, the method performed by a checklist engine, the method comprising receiving, from the development platform, application data indicating a state of the cloud application, determining, based on the application data, that an item of a checklist has been completed, the checklist indicating tasks to be performed for configuring and securing the cloud application for deployment, storing data indicating the completed item is completed in a checklist data database, and causing a view of the checklist to be provided on a display.
Patent WO-2021127428-A1 (WO)
Title: Chimeric antigen receptors targeting b7-h3 (cd276) and associated methods
Inventor: ZANG XINGXING
IPC: A61K31/436
Filed: 2020-12-18
Abstract: In various embodiments, the present disclosure provides chimeric antigen receptors (CAR)s which bind to B7-H3. The B7-H3 CARs comprise an extracellular region comprising a binding domain that specifically binds to at least a portion of B7-H3, a transmembrane region, and an intracellular region comprising an effector domain or a portion or variant thereof and a costimulatory domain or a portion or variant thereof. Recombinant host cells expressing the CARs are also provided, as well as compositions and methods comprising the same.
Patent WO-2021127483-A1 (WO)
Title: Combination treatment of liver diseases using integrin inhibitors
Inventor: ANDERSON KRAIG
IPC: A61P1/16
Filed: 2020-12-18
Abstract: The invention provides a pharmaceutical combination including an ανβ1 integrin inhibitor and at least one additional therapeutic agent for preventing, delaying or treating liver diseases or disorders. The at least one additional therapeutic agent may be a farnesoid X receptor (FXR) agonist. For example, the pharmaceutical combination includes (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(5,6,7,8-tetrahydro-l,8-naphthyridin-2-yl)nonanoic acid (Compound 1) and 2-[3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid (tropifexor).
Patent WO-2021127651-A1 (WO)
Title: Model organisms humanized for drug discovery and screening
Inventor: BROCK TRISHA
IPC: C12N15/85
Filed: 2020-12-21
Abstract: This disclosure relates to methods for screening therapeutic agents to treat altered function of a mutated target gene (e.g., clinical variant) as well as reagents for use in the same.
Patent WO-2021142352-A1 (WO)
Title: Methods and apparatus to assess and prevent hypothermic injury related to cryoablation of the pulmonary vein antra
Inventor: LAKKIREDDY DHANUNJAYA
IPC: A61B18/02
Filed: 2021-01-08
Abstract: The present disclosure describes technology for preventing hypothermal injuries that are related to cryoablation. In some variations, a device may comprise a cryoballoon that is coupled to an elongate member at a proximal portion of the cryoballoon. A temperature probe may be disposed via the elongate member and may be configured to extend from a distal portion of the cryoballoon to one or more structures that are distal to the site of occlusion from the cryoballoon. Additionally or alternatively, in some variations, a device can include a cryoballoon protection device that is disposed distal to the cryoballoon. The cryoballoon protection device may be filled with an inert gas during a cryoablation procedure.
Patent WO-2021154809-A1 (WO)
Title: Cell specific, self-inactivating genomic editing crispr-cas systems having rnase and dnase activity
Inventor: TENOEVER BENJAMIN
IPC: C12N15/11
Filed: 2021-01-27
Abstract: This disclosure provides a CRISPR-Cas system with both RNase and Dnase activity for genetic editing and methods of use thereof. The disclosed CRISPR-Cas system can function in a cell-specific manner, which enables in vivo editing while mitigating the risk of off-target effects.
Patent WO-2021178242-A1 (WO)
Inventor: KHAIRA MANEET
IPC: A63F13/24
Filed: 2021-02-26
Abstract: A game controller for a mobile device, the game controller having a first handle, a bridge, a first spring mechanism, and a first latch mechanism. The first handle is configured to contact and support a mobile device and includes a user-accessible, first hardware interface on a main body portion of the first handle. The bridge is in sliding engagement with the first handle. The bridge and the first handle are configured for the main body portion of the first handle to translate in a retraction direction toward a midline of the bridge and into a retracted configuration and also to translate in an extension direction away from the midline of the bridge into an extended configuration. The first spring mechanism is configured to bias the first handle toward the retracted configuration. The first latch mechanism is configured to temporarily lock the bridge in the extended configuration.
Patent WO-2021178794-A1 (WO)
Inventor: VAN'T SCHIP JOANNES STEFANUS
IPC: B65G15/30
Filed: 2021-03-05
Abstract: A cutting apparatus for forming fingers in an end of a belt is provided and includes a blade for cutting the belt and a table for positioning the belt below the blade. The cutting apparatus includes an actuator that is connected to the blade via a primary shaft. The actuator is also connected to the table via both a secondary shaft and a cam assembly. Rotation of the actuator causes the primary shaft to continuously reciprocate the blade in upward and downward directions. Rotation of the actuator also causes intermittent movement of the table that includes both translation of the table to index the belt relative to the blade, and pivoting of the table to change an angle of the belt relative to the blade.
Patent WO-2021183442-A1 (WO)
Title: Multilayer vascular graft
Inventor: HALL JOHN
IPC: A61M39/02
Filed: 2021-03-08
Abstract: Devices used to provide vascular access, methods of manufacture, and methods of use are disclosed. The devices may be a vascular graft having a wall configured to seal following repeated punctures with a needle. The wall may include a plurality of layers of differing materials. The wall may also include a bead configured to prevent kinking of the vascular graft. The bead may be spirally wrapped around the vascular graft or be discrete C-shaped beads that provide a gap for needle access.
Patent WO-2021194993-A1 (WO)
Inventor: GEDDAM CHANDRASEKHAR
IPC: A62B18/02
Filed: 2021-03-22
Abstract: A method and apparatus for assisting in the removal of foreign particles from the airways and nasal debris from the nostrils of a user are described. The device can be used to prevent the spread of disease or may be used as a safety device to assist in the removal of contaminants or other foreign materials that might be encountered by a user.
Patent WO-2021202493-A1 (WO)
Title: Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof
Inventor: LE CLAIRE LAURIANNE
IPC: A61K8/90
Filed: 2021-03-30
Abstract: The ceramide composition includes capsules dispersed in the ceramide composition, the capsules comprising a shell and a core. The shell includes a polycaprolactone, a block copolymer, and a surfactant. The core includes ceramide NP, hydroxypalmitoyl sphinganine, 2-oleamido-1,3-octadecanediol, and a hydrophobic solvent. The core has a weight ratio of the ceramide NP of (i) and the hydroxypalmitoyl sphinganine of (ii) to the 2-oleamido-1,3-octadecanediol of (iii) is from 1:2.5 to 1:5. Additionally, the ceramide composition includes hydroxyacetophenone and hydrophilic solvent.
Patent WO-2021202518-A1 (WO)
Inventor: KELLY BRYAN
IPC: G07F17/32
Filed: 2021-03-30
Abstract: A gaming system that receives a frame of image data captured by a camera at a gaming table, generates a set of images from portions of the frame of image data, and determines whether the set of images meets an input requirement of a neural network model, if the set of images does not meet the input requirement, the gaming system modifies, by an incremental amount, an image property of a subset from the set of images until the set of images meets the input requirement. When the set of images meets the input requirement, the gaming system transmits the set of images as a unit (e.g., as a composite of the set of images) to the neural network model for concurrent analysis.
Patent WO-2021236275-A1 (WO)
Title: Radio-frequency integrated circuit package employing an electro-magnetic interference shielding layer, and related fabrication methods
Inventor: HAN JEAHYEONG
IPC: H01L23/552
Filed: 2021-04-20
Abstract: Radio-frequency (RF) integrated circuit (IC) (RFIC) packages employing a substrate sidewall partial shield for electro-magnetic interference (EMI) shielding. A RFIC package includes an IC die layer that includes a RFIC die(s) mounted on a substrate that includes substrate metallization layers, a substrate core, and substrate antenna layers. The RFIC package includes an EMI shield surrounding the IC die layer and extending down shared sidewalls of the IC die layer and the substrate. The EMI shield extends down the sidewalls of the IC die layer and substrate metallization layers of the substrate to at least the interface between the substrate metallization layers and the substrate core, and without extending adjacent to the sidewall of the substrate antenna layers. In this manner, antenna performance of the antenna module may not be degraded, because extending the EMI shield down sidewalls of the substrate antenna layers can create a resonance cavity in the substrate.
Patent WO-2021226149-A1 (WO)
Title: Synthesis of optically active indoline derivatives via ruthenium(ii)-catalyzed enantioselective c-h functionalization
Inventor: CUI XIN
IPC: B01J31/28
Filed: 2021-05-04
Abstract: Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C-H bond and activating the unfunctionalized C-H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).
Patent WO-2021231699-A1 (WO)
Title: Ice protection for electrically powered rotors
Inventor: PALACIOS JOSE
IPC: B64D15/02
Filed: 2021-05-13
Abstract: An electrically powered aerial vehicle includes at least one motor where each motor includes a stator and a rotor, a motor housing having an inlet opening and a discharge opening for airflow, a plurality of rotor blades rotatable by the rotor, each of the plurality of rotor blades having a cavity running from a proximal end of the rotor blade towards a distal end of the rotor blade, and a blade hub coupled to the rotor blades at the proximal end of each rotor blade and coupled to the motor housing at the discharge opening. A chamber is defined in the blade hub and is in fluid communication with the discharge opening of the motor housing and the cavity of each rotor blade. The airflow is centrifugally drawn in from the motor housing through the discharge opening and transported through the chamber and into the cavities of the rotor blades when the rotor blades are rotating.
Patent WO-2021257217-A1 (WO)
Title: System and process for dynamic information discovery between commercial shipping assets
Inventor: CORRODI BRAD
IPC: G06Q10/08
Filed: 2021-05-14
Abstract: A commercial shipping asset including a plurality of sensors disposed on the commercial shipping asset. A controller is communicatively connected to each sensor in the plurality of sensors. The controller further includes a master asset identifier and a receiver. The controller is configured to implement a dynamic information discovery protocol.
Patent WO-2022015408-A1 (WO)
Title: System and method for identifying objects of interest in ct images based on likelihood map decluttering
Inventor: PAGLIERONI DAVID W
IPC: G01V5/00
Filed: 2021-05-14
Abstract: An automatic threat recognition system and method is disclosed for scanning the x-ray CT image of an article to identify the objects of interest (OOIs) contained within the article, which are otherwise not always quickly apparent or discernable to an individual. The system uses a computer to receive information from two-dimensional (2D) image slices from a reconstructed computed tomography (CT) scan image and to produce a plurality of voxels for each slice of the 2D image. The computer analyzes the voxels to create a likelihood map (LM) representing likelihoods that voxels making up the CT image are associated with a material of interest (MOI). The computer further analyzes the LM to construct neighborhoods of voxels within the LM, and classifies each voxel neighborhood based on its features, thereby decluttering the LM to facilitate the process of connecting voxels of a like MOI together to form segments. The computer classifies each candidate segment based on its features, thereby identifying those segments that correspond to objects of interest.
Patent WO-2021242545-A1 (WO)
Title: Agents and methods for treating tauopathies
Inventor: EISENBERG DAVID
IPC: A61K31/095
Filed: 2021-05-14
Abstract: Disclosed are agents that include a flavanol (e.g., epigallocatechm-3-gailate) or a flavanol analog, a linker coupled to the flavanol or the flavanol analog, and a earner (e.g., iron oxide nanoparticle) coupled to the linker. The disclosed agents can be used in methods tor destabilizing a tau amyloid fibril, and for treating a tauopathy (e.g., Alzheimer's disease, progressive supranuclear palsy) in a subject.
Patent WO-2021236498-A1 (WO)
Title: Treatment of kras-variant cancers with serotonin uptake inhibitors
Inventor: SWEASY JOANN
IPC: A61K31/502
Filed: 2021-05-17
Abstract: A method of treating a cancer having a KRAS variant in a subject is provided in which an effective amount of one or more serotonin uptake inhibitors is administered to the subject. An example of a serotonin uptake inhibitor is sibutramine. The serotonin uptake inhibitor can be administered alone or in combination with one or more anti-cancer agents. A pharmaceutical composition comprising a serotonin uptake inhibitor and one or more anti-cancer agents is also provided.
Patent WO-2021252835-A1 (WO)
Inventor: ABEND JOHANNA
IPC: C07K16/10
Filed: 2021-06-11
Abstract: L'invention concerne des schémas posologiques d'anticorps neutralisants contre le polyomavirus et des procédés associés et des compositions pharmaceutiques pour le traitement d'infections à polyomavirus.
Patent WO-2022055593-A1 (WO)
Title: Mobile device and assembly process
Inventor: ELLIS ANDREW
IPC: G06F21/44
Filed: 2021-06-24
Abstract: A mobile computing device includes: a front housing having a first sidewall defining a first opening, and a first flange extending into the first opening from an inner surface of the first sidewall; a retaining frame having a second sidewall defining a second opening, and a second flange extending into the second opening from an inner surface of the second sidewall; a display assembly between the first flange and the second flange, the display assembly including a perimeter coupled to a rear surface of the first flange; a first adhesive layer bonding the display assembly with the inner surface of the first sidewall; and a second adhesive layer bonding an outer surface of the second sidewall with the inner surface of the first sidewall.