Patent SG-11201808314Q-A (SG)
Title: Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
Inventor: KRISHNAN SUMA
IPC: C07K19/00
Filed: 2016-12-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011111101110110011101111101111011111 International Bureau ... .1 j ..... .....1 (10) International Publication Number (43) International Publication Date WO 2017/176336 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 15/869 (2006.01) A61P 17/00 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 14/78 (2006.01) C07K 19/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 48/00 (2006.01) C12N 9/02 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 38/39 (2006.01) CO7K 14/47 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2016/068974 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 28 December 2016 (28.12.2016) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/320,316 8 April 2016 (08.04.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: KRYSTAL BIOTECH, LLC [US/US]; 350 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Rhode Island Street, Suite #240, San Francisco, CA 94103 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: KRISHNAN, Suma; c/o Krystal Biotech LLC, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 350 Rhode Island Street, Suite #240, San Francisco, CA GW, KM, ML, MR, NE, SN, TD, TG). 94103 (US). AGARWAL, Pooja; c/o Krystal Biotech Published: LLC, 350 Rhode Island Street, Suite #240, San Francisco, with international search report (Art. 21(3)) CA 94103 (US). — with sequence listing of description (Rule 5.2(a)) part Agents: TSAO, Patricia Morrison & Foerster LLP, (74) et al.; 425 Market Street, San Francisco, CA 94105-2482 (US). (54) Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF WOUNDS, DISORDERS, AND DISEASES OF THE SKIN FIG. 3 BGHpA COL7A1 HCMV lEp -- ---- UL Us -,-- Il ------ HCMV 14 COL7A1 BGHpA Deletions of UL54 (ICP27) and UL55 M &. M , tD Deletion ofAICP4LATGTpICP22/ATGTpICP47, insertion of HCMV IEp-COL7A1-pA cassette Ir ---- 11 N (57) : The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suit- able for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha- 1 (VII) chain polypeptide and/or ei Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in O part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, dis - ,..1: order, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolys - .,- is bullosa.