baber/WOPTO huggingface dataset:
Patent WO-2013181087-A2 (WO)
Inventor: ROSSI EDMUND A
IPC: A61K45/06
Filed: 2013-05-24
Abstract: The present invention concerns multimeric complexes based on antibody fusion proteins comprising an AD moiety attached to the C-terminal end of each antibody light chain. The complexes further comprise effector moities attached to DDD moieties. Two copies of the DDD moiety form a dimer that binds to the AD moiety. The complexes may be trimers, pentamers, hexamers or other multimers. The effector moieties may be selected from a second antibody or antigen-binding fragment thereof, a cytokine, an interferon, a toxin, an antigen, a xenoantigen, a hapten, a protamine, a hormone, an enzyme, a ligand-binding protein, a pro-apoptotic agent and an anti-angiogenic agent. Surprisingly, attachment of the AD moiety to the C-terminal end of the antibody light chain results in improved pharmacokinetics and  in vivo  stability and efficacy, compared to homologous complexes wherein the AD moiety is attached to the antibody heavy chain.
Patent WO-2013177525-A2 (WO)
Inventor: SLEPNEV VLADIMIR I
IPC: C12Q1/68
Filed: 2013-05-24
Abstract: The invention provides methods of detecting a nucleic acid present in a biological sample, comprising combining the biological sample with a lysis buffer to form a lysis mixture comprising nucleic acid released from cells in said biological sample; and subjecting a volume of the lysis mixture to size-exclusion chromatography in a column comprising a volume of size-exclusion medium. In certain embodiments, the lysis buffer separates double-stranded nucleic acid into single- stranded nucleic acid. In certain embodiments, the elution can have a flow rate of separation of less than 10 minutes to produce an eluted solution comprising isolated nucleic acid. The invention provides for a method of accurately and rapidly detecting products of nucleic acid amplification.
Patent WO-2014008172-A2 (WO)
Title: High yield suspension cell line, system and method for making same
Inventor: DENNING GABRIELA D C
IPC: C12N15/85
Filed: 2013-07-01
Abstract: A system and method of adapting host cells to suspension cell culture and suspension cell lines ATCC PTA-12593 and ATCC PTA-12461 produced thereby are disclosed. The method includes the serial replating of substantially undiluted culture cells onto a surface area until cell clumps are visualized and then, upon cell clumping, moving the cells into a suspension culture system.
Patent WO-2014074181-A2 (WO)
Title: Exercise physiology electrolyte management
Inventor: BARTOLOZZI ARTHUR R
IPC: G06F19/00
Filed: 2013-07-18
Abstract: The present invention provides methods for maintaining electrolyte balance and hydration in a person habituated to strenuous physical exertion by assaying perspiration generated by the person under conditions of strenuous physical exertion to determine the volume of perspiration as a function of duration of exertion and the sodium content of the person's perspiration during strenuous physical exertion. The person is assigned to one of a plurality of groups of individuals, each group differing in the amount of sodium present in the perspiration during strenuous physical exertion of individuals assigned to that group. The person is provided after a period of strenuous physical activity a rehydration solution designed for individuals assigned to the group to which the person is assigned. The rehydration solution being provided is in an amount comprising from about 50 volume percent to about 125 volume percent of the amount of perspiration generated by the person over the time period, having from about 75 percent to about 125 percent by weight of the sodium content of the perspiration generated by the person over the time period, and the solution having at least about 75 percent by weight of chloride compared to the chloride content of the perspiration generated by the person over the time period. The present invention also provides for a set of unitary dosage rehydration compositions, each member of the set comprising sodium and chloride wherein the weight percentage of sodium in each member of the set differing from the weight percentage of sodium in the other members of the set by at least about 20 percent, the weight percentage of chloride in each member of the set exceeding the weight percentage of sodium in that member by at least about 40 percent and each member of the set being perceptually labeled to distinguish that member from the other members of the set by one of the human senses.
Patent WO-2014052635-A2 (WO)
Title: Method and system for heat recovery from products of combustion and charge heating installation including the same
Inventor: KANG TAEKYU
IPC: F23L15/00
Filed: 2013-09-26
Abstract: A plurality of independently flow rate-controlled flows of fuel may be preheated at a heat exchanger (or both oxidant and fuel at separate heat exchangers) by heat exchange with a hot shell-side (heat transfer) fluid. The separate flows of hot fuel are directed to associated separate burners where they combust with flows of fuel to produce hot combustion gases. The hot combustion gases are used to preheat the hot shell-side fluid at a recuperator or regenerator.
Patent WO-2014099105-A2 (WO)
Title: Blast shield for high pressure compressor
Inventor: RIOUX PHILIP ROBERT
Filed: 2013-10-07
Abstract: A high pressure compressor includes an inner case wall, a plurality of flanges extending outwardly from the inner case wall, a shield that surrounds at least a portion of at least one of the plurality of flanges to define a chamber that at least partially encases at least one of the plurality of flanges, and a passage at least partially defined by the shield that allows air to circulate into the chamber.
Patent WO-2014152992-A2 (WO)
Title: Quick-coupling for mower blades
Inventor: JOHANSSON JÖRGEN
IPC: A01D34/412
Filed: 2014-03-14
Abstract: A lawn care device may include a cutting deck housing at least one blade, a rotatable shaft, and a blade coupler operably coupled to the rotatable shaft. The blade coupler may define a blade channel configured to at least partially enclose four sides of a blade inserted therein. The blade coupler may include a support base and a sleeve that is movable relative to the support base based on a compression state of a biasing element. The blade may be insertable into the blade channel by orienting the blade to apply a force to sidewalls of the sleeve to shift the biasing element to a compressed state and rotating the blade proximate to the support base to enable the biasing element to shift to an extended state in which sidewalls of the sleeve define sidewalls of the blade channel.
Patent WO-2014169285-A2 (WO)
Title: System for monitoring supercritical fluid processes
Inventor: FETNER MARTIN J
IPC: D06B23/10
Filed: 2014-04-14
Abstract: A system for monitoring and obtaining spectral data from a supercritical fluid process. The system includes a process vessel containing a supercritical fluid, a light source, and a spectrometer. Sampling light emitted by the light source is transmitted into the internal cavity of the process vessel and reflected back to the spectrometer for processing and analysis. The reflected sampling light includes spectral data about the supercritical fluid, thereby allowing process parameters such as the concentration levels of the fluid in the vessel to be generated and monitored for determining the progress of the reaction. Carbon dioxide may be used as the supercritical fluid, in one embodiment, the system may be used in a supercritical fluid textile dyeing process to monitor the progress of the textile colorization.
Patent WO-2014182985-A2 (WO)
Title: Dispositif pliable de filtration d'air
Inventor: GRUENBACHER DANA PAUL
IPC: B01D46/00
Filed: 2014-05-09
Abstract: L'invention concerne un dispositif pliable pour filtrer l'air, comprenant une base, un ventilateur relié de manière fonctionnelle à la base, un filtre à air relié de manière amovible à la base et un manchon extérieur sensiblement imperméable à l'air.
Patent WO-2015047480-A2 (WO)
Title: Bride composite à architecture tissée tridimensionnelle
Inventor: QUINN CHRISTOPHER M
IPC: B64C3/24
Filed: 2014-06-18
Abstract: Selon divers modes de réalisation, l'invention concerne une structure en fibres de carbone. Ladite structure en fibres de carbone peut supporter des charges s'appliquant sur une pièce de moteur dans différentes directions. Par exemple, des surfaces non planes d'un composite comprenant une structure selon l'invention peuvent acquérir une rigidité et/ou une résistance améliorée(s). Ainsi, le délaminage de pièces comprenant une structure selon l'invention peut être réduit. Un tissage tridimensionnel dans l'épaisseur des pièces en fibres de carbone permet d'obtenir un matériau composite à résistance améliorée.
Patent WO-2015006254-A2 (WO)
Title: Extraction de segment interactif dans un apprentissage interactif homme-machine
Inventor: SIMARD PATRICE Y
IPC: G06N20/00
Filed: 2014-07-08
Abstract: Un ensemble de données très volumineux peut être difficile à consulter et/ou analyser. La pertinence peut être améliorée sensiblement en classant automatiquement des demandes et des pages Web dans des catégories utiles, et en utilisant ces résultats de classification comme caractéristiques de pertinence. Une approche approfondie peut nécessiter de créer un grand nombre de classificateurs correspondant aux différrents types d'informations, d'activités et de produits. La création de classificateurs et de schématiseurs est prévue pour de grands ensembles de données. L'exercice des classificateurs et des schématiseurs sur des centaines de millions d'éléments peut exposer une valeur qui est inhérente aux données en ajoutant des métadonnées exploitables. Certains aspects concernent l'exploration active de l'étiquetage, la régularisation automatique et le démarrage à froid, la mise à l'échelle avec le nombre d'éléments et le nombre de classificateurs, la fonctionnalisation active, ainsi que la segmentation et la schématisation.
Patent WO-2015017752-A2 (WO)
Title: Module de commutation pour un dispositif de commande de soupape
Inventor: PENNING BRUCE R
IPC: F16K37/00
Filed: 2014-08-01
Abstract: L'invention concerne un ensemble dispositif de commande de soupape comprenant un premier commutateur qui génère un premier signal d'entrée reposant sur un paramètre fonctionnel d'une soupape de commande, et un ensemble d'amarrage est accouplé au premier commutateur de manière à pouvoir communiquer. Un module de commutation est fixé de manière amovible et accouplé à l'ensemble d'amarrage de manière à pouvoir communiquer de sorte que le premier commutateur soit accouplé au module de commutation de manière à pouvoir communiquer lorsque le module de commutation est fixé à l'élément d'amarrage. Le module de commutation comprend un premier circuit d'émulation conçu pour recevoir le premier signal d'entrée, traiter le premier signal d'entrée et émettre un premier signal de sortie différent du premier signal d'entrée.
Patent WO-2015051243-A2 (WO)
Inventor: MCCANDLISH LARRY E
IPC: C04B28/02
Filed: 2014-10-03
Abstract: The invention provides novel articles of composite materials having hollow interior channels or passageways, or otherwise being hollowed out, and formulations and methods for their manufacture and uses. These hollow core objects are suitable for a variety of applications in construction, pavements and landscaping, and infrastructure.
Patent WO-2015175112-A2 (WO)
Title: Balle à explosif de poussée
Inventor: CALVERT S MILL
Filed: 2015-04-08
Abstract: L'invention concerne une balle définissant une chambre et un mécanisme d'extension d'un corps explosif à partir de la chambre. La chambre présente une partie supérieure plus large qu'une partie inférieure. La balle définit en outre un passage en forme de canal partant de l'extrémité supérieure de la balle. La balle contient le corps explosif engagé de manière coulissante dans le passage en forme de canal. Une tige est reliée au corps et descend depuis le corps dans la partie inférieure de la chambre. Une plaque de poussée est reliée à l'extrémité de tige dans la chambre. La plaque de poussée est en métal à ressorts et lorsque la cartouche est mise à feu, la plaque de poussée monte, poussant le corps de sorte qu'il s'étend à partir de l'extrémité avant de la balle. Lorsque la plaque de poussée monte vers la seconde partie de la chambre, elle se déploie brusquement pour empêcher le mouvement vers le bas de la plaque de poussée et empêche en conséquence la rétractation ultérieure du corps lors du vol.
Patent WO-2016081468-A2 (WO)
Title: Dispositif électro-médical implantable programmable pour une durée de vie accrue
Inventor: HOGG BEVIL
IPC: A61N1/378
Filed: 2015-11-17
Abstract: La présente invention concerne un dispositif permettant de stimuler électriquement un ou plusieurs sites cibles anatomiques chez un patient et destiné à être utilisé dans le traitement d'une pluralité d'états biologiques du patient. Le dispositif comporte un générateur d'impulsions fournissant une stimulation électrique aux sites cibles anatomiques ; une source d'alimentation électrique permettant d'alimenter le générateur d'impulsions ; des électrodes de stimulateur raccordées au générateur d'impulsions permettant de stimuler les sites cibles anatomiques ; une ou plusieurs électrodes de détection facultatives permettant de surveiller des paramètres physiologiques avec référence aux sites cibles anatomiques ; et un microprocesseur programmé pour faire varier une pluralité de paramètres de protocole thérapeutique régissant la stimulation électrique pour ainsi modifier les paramètres de durée de vie de la source d'alimentation électrique.
Patent WO-2016126366-A2 (WO)
Title: Came à joint à phase
Inventor: MURPHY MICHAEL PATRICK
IPC: F16H53/08
Filed: 2016-01-07
Abstract: La présente invention concerne un système qui utilise des actionneurs linéaires pour générer un couple sur un arbre. Dans un mode de réalisation donné à titre d'exemple, un système peut comprendre un arbre et une came fixée. La came comprend un partie d'arc de développement de cercle. Le système comprend également un premier actionneur linéaire et un second actionneur linéaire configurés pour se déplacer le long d'un premier axe et d'un second axe, respectivement. Les actionneurs linéaires sont configurés pour s'accoupler de manière détachable à la came sur la base d'au moins un angle de référence de l'arbre. C'est-à-dire, lorsque l'arbre se met en rotation autour de son axe de rotation au niveau de l'angle de référence, les premier et second actionneurs linéaires peuvent s'accoupler à, et de découpler de, diverses parties de la came. Au fur et à mesure que les actionneurs linéaires s'accouplent à, et se découplent, des diverses parties de la came, différents couples de rotation différentes et/ou différentes plages desdits couples de rotation peuvent être transmis sur l'arbre.
Patent WO-2017027088-A2 (WO)
Inventor: ZHAO XUANHE
IPC: C09D201/02
Filed: 2016-06-02
Abstract: Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm -2 .
Patent WO-2017100639-A2 (WO)
Inventor: ASTERJADHI ALFRED
Filed: 2016-12-09
Abstract: Certains aspects de la présente invention concernent d'une façon générale des communications sans fil et, plus particulièrement, des procédés aptes à assurer une protection de la vie privée dans des communications sans fil. Les procédés peuvent consister à : obtenir, d'un nœud sans fil, une première trame ayant une partie encodée avec des informations concernant un second identifiant (ID), différent d'un premier ID déjà attribué à un appareil; déchiffrer les informations concernant le second ID, en utilisant le second ID comme une adresse d'émetteur lors de la génération de trames destinées au nœud sans fil et en utilisant le second Identifiant comme une adresse de récepteur lors du traitement de trames obtenues du nœud sans fil; et délivrer en sortie les trames destinées au nœud sans fil en vue d'une transmission.
Patent WO-2018039575-A2 (WO)
Title: Modificateurs sulfonés pour flottation par mousse
Inventor: LIU JIANJUN
IPC: B03D1/016
Filed: 2017-08-25
Abstract: L'invention porte sur des compositions améliorées de lavage des drêches pour la séparation par flottation par mousse inverse et sur leurs utilisations, et sur des procédés de flottation par mousse inverse. Les compositions de lavage des drêches comprennent des modificateurs polymères sulfonés qui peuvent agir comme dispersants et dépresseurs, et les compositions sont utilisées de manière appropriée dans la flottation par mousse inverse d'un matériau particulaire contenant des particules ultrafines. Par exemple, les compositions et les procédés peuvent être utilisés dans la séparation d'oxyde de fer enrichi à partir de minerais de fer comprenant de la silice, des silicates et analogues.
Patent WO-2019051503-A2 (WO)
Title: Synthetic promoters useful for expression in plant cells
Inventor: LOQUE DOMINIQUE
IPC: C12N15/82
Filed: 2018-09-11
Abstract: The present invention provides for a genetically modified plant cell or plant, comprising: (a) (i) one or more nucleic acids each encoding one or more transcription factors (or transcription activators) operatively linked to a first tissue-specific or inducible promoter, (ii) one or more nucleic acids each encoding one or more transcription repressors each operatively linked to a second tissue-specific or inducible promoter, or (iii) combinations thereof; and (b) one or more nucleic acids each encoding one or more independent genes of interest (GOI) each operatively linked to a promoter that is activated by the one or more transcription factors (or transcription activators), repressed by the one or more transcription repressors, or a combination of both.
Patent WO-2019051510-A2 (WO)
Title: Catalyzed cushion layer in a multi-layer electrode
Inventor: DIFRANCO DINO
IPC: C25B1/46
Filed: 2018-11-01
Abstract: A zero-gap electrode is taught herein having a non-platinum containing catalytic coating that can be applied  ex situ  or  in 
 situ  and that significantly reduces hydrogen overpotential. Moreover, the electrode taught herein includes a catalyzed fine mesh layer, cushion layer, and rigid backing. The fine mesh may be flexible and electrically conductive, and may have a catalytic coating consisting essentially of one or more of cobalt, gold, iridium, osmium, palladium, rhenium, rhodium, ruthenium, or silver. The cushion layer may be in electrical communication with the fine mesh layer, and may have a catalytic coating consisting essentially of one or more of cobalt, gold, iridium, osmium, palladium, rhenium, rhodium, ruthenium, or silver.
Patent WO-2019168648-A2 (WO)
Inventor: RIVERA JONATHAN ORTIZ
IPC: G06F3/0481
Filed: 2019-02-07
Abstract: Systems and methods for estimating relevant functionalities are disclosed. Example embodiments include a system for estimating relevant functionalities. The system may include a receiver adapted to receive incoming signals and a transmitter adapted to send outgoing signals. Additionally, the system may include circuitry coupled to the transmitter and receiver. The system may cause the circuitry to use the receiver to obtain information gathered from one or more applications supported by the electronic device. The system may cause the circuitry to remove a subset of personally identifying information from the information obtained. The system may determine an estimated user preference for a functionality of a set of functionalities using the information obtained. The functionality may correspond to an icon in an array of icons presentable on a display of the electronic device. The system may use the transmitter to communicate the estimated user preference for the functionality to the electronic device.
Patent WO-2019178502-A2 (WO)
Title: Multi-purpose smart tower
Inventor: LALOS DIMITRIOS
IPC: H04W4/80
Filed: 2019-03-15
Abstract: The present invention relates to a tower comprising multifunction smart node and interactive kiosk for use with a modular, multipurpose tower, to be used in smart city applications, citywide Wi-Fi deployments, video surveillance applications, environmental sensors and other communication venues (wired or wireless) involving wireless network deployments of various wireless technologies. The tower includes modular compartments that can be configured for multiple applications and a central support pole.
Patent WO-2019222444-A2 (WO)
Title: Directed evolution
Inventor: HOU JINZHAO
IPC: C07K19/00
Filed: 2019-05-16
Abstract: The disclosure provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
Patent WO-2020185909-A2 (WO)
Title: Lyophilization loading tray assembly and system
Inventor: JOHNSON NATHANIEL T
Filed: 2020-03-11
Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vaccum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.
Patent WO-2020247465-A2 (WO)
Inventor: REYNOLDS CLARENCE MICHAEL
IPC: A01N65/08
Filed: 2020-06-03
Abstract: Methods for controlling plant pests are disclosed. In particular, insecticidal proteins having toxicity to Spodoptera insect pests are provided. Polynucleotides comprising codons optimized for expression in plants encoding the insecticidal proteins are also provided. Methods of making the insecticidal proteins and methods of using the insecticidal proteins and polynucleotides encoding the insecticidal proteins of the invention, for example in transgenic plants to confer protection from insect damage, are also disclosed.
Patent WO-2021030462-A2 (WO)
Inventor: DICKINSON ERIC
IPC: F24F1/00
Filed: 2020-08-12
Abstract: Described herein is an improved HVAC system and method of configuring an HVAC system for cost-effective installation and energy efficient operation for multiple unit residential buildings. In one example embodiment, a mechanical room is sized to simultaneously house most of the HVAC equipment but to also advantageously operate as the HVAC system's air mixing chamber for a wall-mounted temperature and humidity conditioning unit and a blower assembly, based on maximum heating and cooling loads and the minimally required air flow requirement for a defined living space. This advantage allows for elimination of one or more mechanical plenums for air mixing space as well as flexibility in locating HVAC components in the space provided.
Patent WO-2021041309-A2 (WO)
Title: Improved ofdm ranging using position reference symbol phase
Inventor: KURBY CHRISTOPHER NEIL
IPC: H04J11/00
Filed: 2020-08-24
Abstract: Improved approaches for use of RF signals (e.g., OFDM signals) for determining a range that can be used for geolocation of a device. The disclosure includes systems and methods that may allow for transition from a correlation approach to a group delay approach. In addition, upon detection of the presence of multipath error in a signal, a signal bandwidth may be increased to as to include additional position reference symbols (PRS) that are included in a determination of a propagation delay, and in turn, a range. In addition, use of a different number of symbols in a signal based on signal SNR is presented.