Patent SG-11201909324W-A (SG)
Title: Phase separation behavior modifying agents for aqueous two-phase separation within porous material
Inventor: CHIU YIN TO
IPC: C07K1/14
Filed: 2018-06-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 06 December 2018 (06.12.2018) W I P0 I P C T omit °nolo ommominio ois (10) International Publication Number WO 2018/222972 Al (51) International Patent Classification: BOlD 15/00 (2006.01) C07K 1/14 (2006.01) (21) International Application Number: PCT/US2018/035569 (22) International Filing Date: 01 June 2018 (01.06.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/513,994 01 June 2017 (01.06.2017) US 62/599,001 14 December 2017 (14.12.2017) US (72) Inventors; and (71) Applicants: CHIU, Yin To [CN/US]; 21 Tree Clover, Irvine, California 92618 (US). LEE, Brian Sangwoo [US/US]; 13211 Royalcrest Ct., Unit 196, La Mirada, Cali- fornia 90638 (US). MOSLEY, Garrett Lee [US/US]; 2115 Sherington Place D207, Newport Beach, California 92663 (US). LIM, Beatrice S. [US/US]; 756 E. Valencia St., Ana- heim, California 92805 (US). (74) Agent: CHAN, Albert Wai-Kit; LAW OFFICES OF AL- BERT WAI-KIT CHAN, PLLC, World Plaza, Suite 604, 141-07 20th Avenue, Whitestone, New York 11357 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, = (54) Title: PHASE SEPARATION BEHAVIOR MODIFYING AGENTS FOR AQUEOUS TWO-PHASE SEPARATION WITHIN POROUS MATERIAL Figure 1 Blank Uniform Partial Gradient Mixed N 00 O C (57) : The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embod- iment, the present method and device comprise ATPS components within a porous material and one or more phase separation behav- ior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components. [Continued on next page] WO 2018/222972 Al MIDEDIMOMOIDEIREIHNOHOHOIROMOHMEMNIE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(0) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3))