Patent RU-2641291-C2 (RU)
Inventor: TAKAYAMA TETSUO
IPC: C07D401/14
Filed: 2013-07-29
Granted: 2018-01-17
Abstract: FIELD: chemistry.SUBSTANCE: invention relates to a compound of the formula (I'),(wherein W represents the formula -CRRCRR-; Rrepresents a hydrogen atom, a fluorine atom, Calkyl or phenyl; Rrepresents a hydrogen atom, a fluorine atom or Calkyl; provided that Rand R, together with the adjacent carbon atom, optionally form Ccycloalkane or tetrahydropyran; Rrepresents a hydrogen atom, a carbamoyl, Calkyl (Calkyl is optionally substituted by one group selected from the group consisting of hydroxy, Calkoxy and di-Calkylamino), halo-Calkyl, phenyl, pyridyl, benzyl or phenethyl; Rrepresents a hydrogen atom, Calkyl or halogen-Calkyl; Y represents a single bond or Calkanediyl (Calkanediyl is optionally substituted by one hydroxy group and one of the carbon atoms in Calkanediyl is optionally substituted by cycloalkpropane-1,1-diyl); Rrepresents a hydrogen atom, Calkyl, Ccycloalkyl {Ccycloalkyl is optionally substituted by one or two groups that are the same or different and are selected from the group consisting of Calkyl (Calkyl is optionally substituted by one phenyl group), phenyl (phenyl is optionally substituted by one halogen atom), Calkoxy [Calkoxy is optionally substituted by one group selected from the group consisting of Ccycloalkyl, phenyl (phenyl is optionally substituted by one group selected from the group consisting of a halogen atom and Calkyl) and pyridyl (pyridyl is optionally substituted by one halogen atom)], Ccycloalkoxy, phenoxy (phenoxy is optionally substituted by one group selected from the group consisting of a halogen atom, Calkyl, Ccycloalkyl and halogen-Calkyl) and pyridyloxy (pyridyloxy is optionally substituted by one group selected from the group consisting of a halogen atom, Calkyl, Ccycloalkyl and halogen-Calkyl)}, phenyl (phenyl is optionally substituted by one to three groups that are the same or different and which are selected from the group of α3 substituents), naphthyl, indanyl, tetrahydronaphthyl, pyrazolyl [pyrazolyl is optionally substituted by one or two groups that are the same or different and are selected from the group consisting of Calkyl and phenyl (phenyl optionally substituted by one Calkyl)], imidazolyl [imidazolyl is optionally substituted by one or two groups that are the same or different and are selected from the group consisting of Calkyl and phenyl], isoxazolyl [isoxazolyl is optionally substituted by one phenyl group (phenyl is optionally substituted by one halogen atom)], oxazolyl [oxazolyl is optionally substituted by one or two groups that are the same or different and which are selected from the group consisting of Calkyl and phenyl], thiazolyl [thiazolyl is optionally substituted by one or two groups that are the same or different and which are selected from the group consisting of Calkyl, phenyl and morpholino], pyridyl (pyridyl is optionally substituted by one or two groups that are are the same or different and are selected from the group of α5 substituents), pyridazinyl [pyridazinyl is optionally substituted by one Calkoxy (Calkoxy is optionally substituted by one Ccycloalkyl group)], pyrimidinyl [pyrimidinyl is optionally substituted by one group selected from the group consisting of halogen-Calkyl, Ccycloalkyl, phenyl and phenoxy (phenoxy is optionally substituted by one Calkyl)], pyrazinyl [pyrazinyl is optionally substituted by one group selected from the group consisting of Calkoxy (Calkoxy is optionally substituted by one Ccycloalkyl), and phenoxy (phenoxy is optionally substituted by one group selected from the group consisting of a halogen atom, Calkyl and Ccycloalkyl)], benzothiophenyl, quinolyl, methylenedioxyphenyl (methylenedioxyphenyl is optionally substituted by one or two fluorine atoms), azetidinyl (azetidinyl is optionally substituted with one pyrimidinyl group), piperidinyl (piperidinyl is optionally substituted by one group selected from the group consisting of pyrimidinyl, phenyl-Calkyl, Ccycloalkyl-Calkylcarbonyl and phenyl-Calkoxycarbonyl) or the following formula (I") -CONRCH-R(I") [wherein in formula (I") Rrepresents a hydrogen atom or Calkyl and Ris phenyl (phenyl is optionally substituted by one group selected from the group consisting of a halogen atom, halogen-Calkyl and phenyl)], Yrepresents Calkanediyl; Rrepresents a hydrogen atom or methyl; Rrepresents -COOH or -CONHOH).EFFECT: compound has a superior PHD2 inhibitory effect.16 cl, 28 tbl, 11 ex