baber/WOPTO huggingface dataset:
Patent NZ-578948-A (NZ)
Title: Glucagon/glp-1 receptor co-agonists
Inventor: DAY JONATHAN
IPC: C07K14/605
Filed: 2008-02-13
Abstract: Disclosed is a non-native glucagon peptide wherein said analog comprises1 to 3 amino acid modifications and wherein said glucagon peptide exhibits enhanced activity at the GLP-1 receptor, as compared to native glucagon, wherein the glucagon peptide comprises an intramolecular bridge between the side chains of two amino acids that are separated by three intervening amino acids to provide the enhanced activity at the GLP-1 receptor, or a pharmaceutically acceptable salt of said glucagon peptide.
Patent NZ-581361-A (NZ)
Title: Transgenic plants that comprise proteins with aryloxyalkanoate dioxygenase activity
Inventor: LIRA JUSTIN M
IPC: C12N15/82
Filed: 2008-05-09
Abstract: Disclosed is a transgenic plant cell comprising a polynucleotide that encodes a protein having aryloxyalkanoate dioxygenase activity, wherein a nucleic acid molecule that encodes said protein hybridizes under stringent conditions with the full complement of a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, and SEQ ID NO:5 which encode an AAD-13 gene which confers resistance to a pyridyloxy auxin herbicide and an phenoxy auxin herbicide. Further disclosed are plant optimized polynucleotides as defined above.
Patent NZ-581487-A (NZ)
Title: Water-soluble iron-carbohydrate derivative complexes, preparation thereof and medicaments comprising them
Inventor: REIM STEFAN
IPC: A61K33/26
Filed: 2008-05-21
Abstract: Disclosed is a water-soluble iron-carbohydrate derivative complex obtained from an aqueous iron(llI) salt solution and an aqueous solution of the product of the oxidation and subsequent derivatisation of one or more maltodextrins, wherein the oxidation is carried out with an aqueous hypochlorite solution at a pH value in the alkaline range, wherein one maltodextrin is used its destrose equivalent is from 5 to 20 and when a mixture of a plurality of maltodextrins is used the dextrose equivalent of the mixture is from 5 to 20 and the dextrose equivalent of the individual maltodextrins in the mixture is from 2 to 40, and the subsequent derivatisation is carried out with a suitable reagent. Further disclosed is a process for the preparation of an iron-carbohydrate complex as defined above, and wherein the derivatisation of the oxidised maltodextrin is carried out by one of the following processes: a) esterification with organic or inorganic acids or derivatives thereof, b) oxidation, c) carboxylalkylation, d) etherification, e) amidation, f) carbamate formation or g) anhydride formation. Further disclosed is a medicament which comprises an aqueous solution of an iron-carbohydrate derivative complex as defined above for the treatment or prophylaxis of iron deficiency states or anaemias.
Patent NZ-581666-A (NZ)
Title: Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
Inventor: MATSUDA MAMORU
IPC: A61K31/498
Filed: 2008-05-29
Abstract: Disclosed is a compound represented by formula (1) or a salt thereof wherein R1 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent or an aralkyl group which may have a substituent; R2 represents a hydrogen atom or a lower alkyl group which may have a substituent; R3 represents a hydrogen atom or a lower alkyl group which may have a substituent; R4 and R5 may be the same or different and represent a hydrogen atom or a lower alkyl group which may have a substituent; R6 represents a hydrogen atom or a lower alkyl group which may have a substituent; R7 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent or a heterocyclic group which may have a substituent; W represents an oxygen atom, a sulfur atom or NR8; R8 represents a hydrogen atom or a lower alkyl group which may have a substituent; X represents an oxygen atom or a sulfur atom; Y represents a lower alkylene group which may have a substituent; Z represents an oxygen atom, a sulfur atom, NR9, OCO or OSO2; R9 represents a hydrogen atom or a lower alkyl group which may have a substituent. The disclosed compounds are modulators of glucocorticoid receptors and are disclosed for use the manufacture of a medicament for treatment or prevention of metabolic disorders, inflammatory diseases, autoimmune diseases, allergic diseases, central nervous system diseases, cardiovascular diseases, homeostasis-related diseases or glaucoma.
Patent NZ-592006-A (NZ)
Title: Processes for the alkylation of secondary amine groups of morphinan derivatives
Inventor: WANG PETER X
IPC: C07D489/12
Filed: 2009-09-29
Abstract: 592006 Disclosed is a process for the preparation of a morphinan comprising a tertiary amine at position C-17, the process comprising contacting a morphinan comprising a secondary amine at position C-17 with a protic solvent, and an alkylating agent, the alkylating agent being selected from the group consisting of alkyl halides, to form the morphinan comprising a tertiary amine at position C-17, wherein the morphinan comprising a secondary amine at position C-17 is a compound comprising Formula (Ia) and the morphinan comprising a tertiary amine at position C-17 is a compound comprising Formula (IIa) according to the following reaction: wherein the variables are defined in the specification the mole-to-mole ratio of the alkylating agent to protic solvent to compound comprising Formula (Ia) is from about 1:0.2:1 to about 2:5:1, the reaction is conducted in the presence of a proton acceptor, and the reaction is conducted at a temperature ranging from about 30 degrees C to about 85 degrees C.
Patent NZ-592162-A (NZ)
Title: Roof Rack Leg
Inventor: HUBBARD PETER DOUGLAS
IPC: B60R9/04
Filed: 2011-04-08
Abstract: A leg 1 or a vehicle roof rack linking a vehicle rail to a crossbar 3, comprises a crossbar receiver 4 to support a crossbar 3 that includes a crossbar receiving portion, a fixed portion 7 that communicates with a first vertical surface 8 of the rail 2, and a movable clamping portion. The movable clamping portion includes a clamp arm 10 and a clamp pad 11 which communicates with an opposing second vertical surface 12 of the rail 2, and releasably attaches the leg 1 to a rail 2 about the first and second vertical rail surfaces. The clamp arm 10 is angled towards the second vertical surface 12 of the rail 2, and nests a complementary wedge shaped clamp pad 11 between the arm interior and the second vertical surface of the rail. As the clamp portion is moved against the second vertical surface of the rail 2 to tighten the leg 1 to the rail 2, the clamp arm 10 pulls the leg 1 onto the 2 rail by virtue of the wedge action of the clamp pad 11 and so any upwards force on the leg 1 will cause the arm 10 and pad 11 to tighten further against the rail 2 preventing any upward movement.
Patent NZ-594011-A (NZ)
Title: Deoxyactagardine derivatives
Inventor: WADMAN SJOERD NICOLAAS
IPC: A61K38/12
Filed: 2010-01-12
Abstract: Abstract 594011 Diclosed is Deoxyactagardine B (7-amino-1-heptylamide monocarboxarnide), and pharmaceutically acceptable salts, hydrates and solvates thereof.suitable for use in the treatment of microbial infections, for example Clostridium infection, such as C. perfringens, C. difficile, C.tetani, and/or C. botulinum, in particular C. difficile, especially infection of the colon and/or lower intestines and diarrhea associated with the microbial infection.
Patent NZ-595249-A (NZ)
Title: A spring biased self latching lock for securely closing the lid of an enclosure
Inventor: BURKE EDWARD J
IPC: E05B35/00
Filed: 2010-01-28
Abstract: 595249 A self-latching locking system for securely closing the lid (22) on an enclosure is disclosed. The self-latching locking system comprises a self-latching locking assembly, which is separate from the lid of the enclosure, which comprises a rigid guide frame containing an elongate spring biased self-latching slide member (40) which travels linearly in an elongate recess in the guide frame. The guide frame further comprises an elongate rigid base plate with fastening means for rigidly securing the base plate to the lower surface of the lid. The slide member engages an abutment on the inside of the enclosure. When the lid is forced down over an opening in the enclosure downward force on the lid progressively causes the slide member to retract against the spring-bias from contact with the abutment and then snap the latch into a spring-biased locking position under the abutment. The self-latching locking system further comprises an L-bolt (52), rotatably mounted in a slotted housing under the lid, connected to the spring-biased slide member. The L-bolt is accessed from outside the lid and rotated by a proprietary socket wrench or similar tool in order to retract the latch from its locking position, such that the lid of the enclosure can be opened.
Patent NZ-596034-A (NZ)
Title: Print carriage
Inventor: BENNET SIMON
IPC: B41J2/21
Filed: 2010-04-28
Abstract: A print carriage (36) for the deposition of a substance onto a substrate (22) and a printer provided with such a print carriage (36) for textile printing and finishing. The print carriage (36) is arranged for printing in diagonal mode onto a continuously moving substrate (22), the print carriage (36) comprising: a first plurality of inkjet heads (46) arranged to deposit a substance onto the substrate (22) in forward and reverse passes of a first diagonal swathe (P); and a second plurality of ink jet heads (48) arranged to deposit the substance onto the substrate (22) in forward and reverse passes of a second diagonal swathe (S). The first (P) and second (S) swathes complement one another on both forward and reverse passes and uniform coverage is achieved by superposition of the first (P) and second (S) swathes such that each portion of the substrate (22) is covered either twice by one of the swathes (P, S) or once by each swathe (P, S).
Patent NZ-596215-A (NZ)
Title: Extended release formulations of erythromycin derivatives
Inventor: CRAMPTON SHERI L
IPC: A61P31/04
Filed: 1998-03-06
Abstract: 596215 EXTENDED RELEASE FORMULATIONS OF ERYTHROMYCIN DERIVATIVES Provided is a pharmaceutical composition for extended release of clarithromycin in the gastrointestinal environment, comprising 50% by weight clarithromycin and from 10 to 30% by weight of hydroxypropylmethyl cellulose having a viscosity of 100 cps, so that when ingested orally, the composition induces statistically significantly lower mean fluctuation index in the plasma than an immediate release composition of clarithromycin while maintaining bioavailability substantially equivalent to that of the immediate release composition of clarithromycin, preparable by dry blending the polymer, clarithromycin, and other excipients followed by granulating the mixture using water until proper granulation is obtained.
Patent NZ-598402-A (NZ)
Title: Tubular electrochemical cell
Inventor: MARCHAL FREDERIC
IPC: C25B9/19
Filed: 2010-09-15
Abstract: 598402 A membrane electrode assembly (MEA) comprises substantially concentric and tubular-shaped layers of a cathode, an anode and an ion- exchange membrane. The MEAs can be used in an electrochemical cell, which comprises the following layers which are tubular-shaped, arranged substantially concentrically, and listed from the inner layer to the outer layer; (i) a cylindrical core; (ii) one of the electrodes; (iii) a membrane; (iv) the other of the electrodes; and (v) an outer cylindrical sleeve.
Patent NZ-599896-A (NZ)
Title: Itse for cancer intervention and eradication
Inventor: SONG JIASHENG
IPC: C07D277/56
Filed: 2010-10-14
Abstract: Disclosed is the use of 2-(1’H-indole-3’-carbonyl)-thiazole-4-carboxylic acid methyl thioester / 2-(1H-indol-3-ylcarbonyl)-4-thiazole carboxylic acid methyl thioester (abbreviated as ITSE), in the manufacture of a medicament for treating cancer (preferably selected from prostate, liver, lung, ovarian and breast cancer), wherein the medicament is formulated to deliver to a patient between 1 and 80 mg/kg of the ITSE, and preferably wherein the medicament has a dosing schedule of once or twice daily. Also herein disclosed is the recently prepared compound 2-(1H-indol-3-ylcarbonyl)-N-methyl-1,3-thiazole-4-carboxamide / N-methyl-2-(1H-indol-3-ylcarbonyl)-1,3-thiazole-4-carboxamide (abbreviated as ITA).
Patent NZ-600933-A (NZ)
Title: Dietary fiber composition comprising glucomannan, xanthan gum, alginate and lipid
Inventor: GAHLER ROLAND J
IPC: A23L29/256
Filed: 2008-07-29
Abstract: ABSTRACT - 600933 The disclosure relates to the use of a dietary composition comprising a fiber composition comprising from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate in the 5 manufacture of a medicament for reducing the glycemic volatility in a subject in need thereof; wherein the medicament is adapted for administration to the subject in an amount from 5.0g to 15.0g per day, and wherein the medicament is adapted for administration to the subject for at least 4 week, and wherein the fiber composition comprises granules in the size range of from about 40 mesh to about 60 mesh.
Patent NZ-605665-A (NZ)
Title: Marine fender load monitoring
Inventor: SMITH SCOTT
IPC: G01L1/22
Filed: 2011-07-25
Abstract: 605665 A marine fender (100) for mounting to a structure (108) and a mounting assembly (110) for a marine fender is disclosed. The marine fender includes a facing assembly (102) for bearing against a vessel and a resilient fender element (104) for absorbing forces on the facing assembly. The fender element is mounted between the facing assembly and the structure. One or more load sensing elements are positioned to measure forces applied to the facing assembly and outputting force data relating to the measured forces. A system for monitoring the load on the marine fenders is also described which is able to monitor forces borne by marine fenders during the docking of a vessel and or whilst the vessel remains docked.
Patent NZ-610168-A (NZ)
Title: Sound suppressor for firearm
Inventor: BLADEN JOHN WILLIAM
IPC: F41A21/28
Filed: 2011-07-12
Abstract: A sound suppressor for firearms (such as hand guns and rifles) has a tubular body with a first end cap adjacent the barrel of the firearm, and a 5 second end cap with exhaust vents for the gases. A plurality of baffles, each having a passage for the bullet, are provided in the body intermediate the first-and-second end caps. Each baffle has a plurality of vents in the outer portion, the vents forming at least one path for the flow of the major portion of the gases through the suppressor body. By angularly offsetting the vents of adjacent baffles, the gas path(s) are made tortuous to further slow the gas flow. The baffle adjacent the first end cap can be a deflecting baffle, where the vents deflect the gases outwardly towards the body. The body may be connected to the barrel of the firearm by screw-threads or a bayonet coupling; and a flash eliminator may be connected to the body adjacent the second end cap.
Patent NZ-618388-A (NZ)
Title: Process for producing at least one product from at least one gaseous reactant in a slurry bed
Inventor: BREMAN BERTHOLD BEREND
IPC: B01J8/18
Filed: 2012-05-30
Abstract: A process for producing at least one product from at least one gaseous reactant includes feeding the gaseous reactant, as a gaseous feed (59) or as part of a gaseous feed (59) which is at an inlet superficial gas velocity of at least 0.5 m/s, into a vessel (12) holding an expanded slurry bed (70) of solid catalyst particles suspended in a suspension liquid so that the gaseous reactant can bubble upwardly through the slurry bed (70). The slurry bed (70) has a catalyst loading of at least 20% by volume of degassed slurry. The gaseous reactant is allowed to react catalytically at a pressure above atmospheric pressure as the gaseous reactant bubbles upwardly through the slurry bed (70) to produce at least one product. The product and any unreacted gaseous reactant are withdrawn from the vessel (12).
Patent NZ-620654-A (NZ)
Title: Compositions and methods for detecting allelic variants
Inventor: SINGH SHARAT
IPC: C12Q1/68
Filed: 2012-08-17
Abstract: A method for detecting or quantitating a first allelic variant of a target sequence in a nucleic acid sample suspected of having at least a second allelic variant of the target sequence is disclosed. The a reaction mixture is formed by combining (i) the nucleic acid sample; (ii) an allele-specific primer, wherein an allele-specific nucleotide portion of the allele-specific primer is complementary to the first allelic variant of the target sequence, and the allele-specific primer comprises at least one nucleic acid modification; (iii) an allele-specific blocker probe that is complementary to a region of the target sequence comprising the second allelic variant and the allele-specific blocker probe comprises a non-extendable 3’-hexanediol, blocker moiety and at least one nucleic acid modification; (iv) a detector probe; and (v) locus-specific primer that is complementary to a region of the target sequence where the region of the target sequence complementary to the locus-specific primer is 3’ from the first allelic variant; and on the opposite strand. Then an amplification reaction on the reaction mixture using the locus-specific primer and the allele-specific primer to form an amplicon is carried out. The amplicon is detected by detecting a change in a detectable property of the detector probe, thereby detecting the first allelic variant of the target gene in the nucleic acid sample. A composition comprises (a) an allele-specific primer, wherein an allele-specific nucleotide portion of the allele-specific primer is complementary to a first allelic variant of a target sequence and the allele-specific primer comprises at least one nucleic acid modification; and (b) an allele-specific blocker probe that is complementary to a region of the target sequence comprising a second allelic variant, and the allele-specific blocker probe comprises a non-extendable 3’-hexanediol, blocker moiety and at least one nucleic acid modification. The composition can further comprise (c) a detector probe; and/or (d) a locus-specific primer that is complementary to a region of the target sequence that is 3’ from the first allelic variant and on the opposite strand. A reaction mixture comprising the above described composition and (e) a nucleic acid molecule is also disclosed.
Patent NZ-623100-A (NZ)
Title: 8 - carbamoyl - 2 - (2,3- di substituted pyrid - 6 - yl) -1,2,3,4 -tetrahydroisoquinoline derivatives as apoptosis - inducing agents for the treatment of cancer and immune and autoimmune diseases
Inventor: SOUERS ANDREW
IPC: C07D513/04
Filed: 2012-10-11
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, e.g. cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(O)OR9, C(O)NR10R11, C(O)R11, NR10C(O)R11, etc. In one embodiment, the compound of formula (I) is 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-{ 1-[tricyclo[3.3.1.13,7]dec-1-ylmethyl]-1H-pyrazol-4-yl} pyridine-2-carboxylic acid.
Patent NZ-702070-A (NZ)
Title: Substituted pyrrolidines as factor xia inhibitors for the treatment thromboembolic diseases
Inventor: COURTNEY STEVE
IPC: C07D413/14
Filed: 2013-05-23
Abstract: The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.
Patent NZ-704816-A (NZ)
Title: Device for providing liquid for a beverage machine and use thereof
Inventor: REYHANLOO SHAHRYAR
IPC: A47J31/60
Filed: 2013-08-28
Abstract: A coffee machine includes a device (100) for providing liquid for the machine (110), comprising a water tank (10) having at least one water inlet (11) which can be connected in a controllable manner to a water connection in order to fill the water tank (10) and having an outlet (15) for letting a liquid out the water tank (10), a control device (30) for controlling the water inlet (11), and at least one filling level sensor (41, 42) for generating a signal which indicates at least whether or not a first filling level of liquid inside the water tank (10) has been reached or exceeded. In order to achieve easier cleaning, in particular descaling of the device (100), the at least one filling level sensor (41, 42) can be or is connected to the control device (30) to transmit the signal and the control device (30) is designed to control the water inlet (11) according to the signal of the at least one filling level sensor (41, 42) and according to at least one operating mode, wherein the operating mode is either a filling mode or an emptying mode. Furthermore, a controllable drainage device (44) for draining liquid from the water tank (10) is present. In the emptying mode, the control device (30, 30a) is designed to interrupt a connection of the water inlet (11) to the water connection (21) and to prompt the drainage device (44) to completely drain a quantity of liquid contained in the water tank (10) through the outlet (15)and to allow it to discharge through the water line (45) and the continuous-flow heater (52), so that a complete emptying of the water tank (10) takes place.
Patent NZ-733654-A (NZ)
Title: Ligament fixation device and method
Inventor: HOOVER TIMOTHY R
IPC: A61F2/08
Filed: 2016-01-27
Abstract: An anchor system 200 for a ligament comprises an outer tube 120 with an external thread 122, a threaded inner tube 130 received within the outer tube 120, and a compression screw 140 received within the inner tube 130 to trap a suture between the inner tube 130 and the screw 140. The system maintains the tension on the graft sutures.
Patent NZ-734330-A (NZ)
Title: Hash tag load balancing
Inventor: WILSON STUART
IPC: H04L29/08
Filed: 2014-07-28
Abstract: A computer-implemented method of distributing netflow records is disclosed. The method includes receiving a plurality of netflow records, each including at least a source internet protocol (IP) address and a destination IP address; for each netflow record, performing a bit-wise exclusive-or (XOR) logical operation between respective bits of the source IP address and the destination IP address; generating a hash tag for the netflow record in response to the bitwise exclusiveor logical operation; and tabulating the hash tag and associated netflow record into a load balancing table in response to applying a load balancing function to the hash tag. The method also includes receiving a plurality of netflow records, each netflow record associated with a hash tag. The hash tag may include, for example, a random M-bit pattern of bits. The method filters the plurality of netflow records over a first hash tag range in response to the hash tag value and storing the first filtered netflow records in a first queue associated with a first netflow collector; filters the plurality of netflow records over a second hash tag range in response to the hash tag value and storing the second filtered netflow records in a second queue associated with a second netflow collector, wherein the second hash tag range differs from the first hash tag range; sends the first filtered netflow records from the first queue to the first netflow collector; and sends the second filtered netflow records from the second queue to the second netflow collector.