Patent SG-11201903348U-A (SG)
Title: Therapeutic compounds and methods of use thereof
Inventor: SUTHERLIN DANIEL
IPC: C07D285/08
Filed: 2017-09-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111111111111010111 01111101011H01111110111100111111111111110111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/072602 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: C07D 285/08 (2006.01) A61P 19/02 (2006.01) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 31/427 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: PCT/CN2017/103499 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (22) International Filing Date: 26 September 2017 (26.09.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: PCT/CN2016/102263 Published: 17 October 2016 (17.10.2016) CN — with international search report (Art. 21(3)) (71) Applicants: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, CA 94080-4990 (US). XENON PHARMACEUTICALS INC. [CA/CA]; 200-3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). (72) Inventors; and _ (71) Applicants (for MN only): SUTHERLIN, Daniel [US/US]; 1 DNA Way, South San Francisco, CA = 94080-4990 (US). MCKERRALL, Steven [US/US]; 1 DNA Way, South San Francisco, CA 94080-4990 (US). = WILSON, Michael Scott [CA/CA]; 200-3650 Gilmore — = Way, Burnaby, British Columbia V5G 4W8 (CA). LAI, Kwong Wah [CN/CN]; 288 Fute Zhong Road, WaiGao- = = Qiao Free Trade Zone, Shanghai 200131 (CN). BERG- = ERON, Philippe [CA/US]; 1 DNA Way, South San Fran- cisco, CA 94080-4990 (US). ZHANG, Birong [US/US]; 1 — DNA Way, South San Francisco, CA 94080-4990 (US). = (74) Agent: WU, FENG & ZHANG; Sinosteel Plaza, 21st Floor A/D, 8 Haidian st., Haidian, Beijing 100080 (CN). = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = (81) = = = = — = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = 1-1 (54) ei Title: THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 0 (57) : The invention provides a compound of formula I: or a pharmaceuti- D cally acceptable salt thereof, wherein the variables X, )( I -y -5 , R 1 , R 2 , — x3, R4, and Het IN IN R 2 0 p have the meaning as described herein, and compositions containing such compounds CZ 3 Het and methods for using ..Y.?, R1 s„ [1 such compoundsand compositions. 11 OO --.... r Y 1 0 (I) Ye y5 r., z R3 CZ ei X R 4 O