Patent SG-11201806745R-A (SG)
Title: Sulfonylureas and related compounds and use of same
Inventor: O'NEILL LUKE
IPC: C07D295/26
Filed: 2017-02-16
Abstract: WO 17 / 14077 8 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/140778 Al 24 August 2017 (24.08.2017) WIPO I PCT (51) International Patent Classification: C07D 231/18 (2006.01) CO7C 307/10 (2006.01) C07C 307/06 (2006.01) C07D 295/26 (2006.01) C07C 307/08 (2006.01) A61P 29/00 (2006.01) (21) International Application Number: PCT/EP2017/053498 (22) International Filing Date: 16 February 2017 (16.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016900535 16 February 2016 (16.02.2016) AU (71) Applicants: THE UNIVERSITY OF QUEENSLAND [AU/AU]; St Lucia, Queensland 4072 (AU). THE PROV- OST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRIN- ITY OF QUEEN ELIZABETH NEAR DUBLIN [IE/IE]; College Green, Dublin 2 (IE). (72) Inventors: O'NEILL, Luke; Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2 (IE). COLL, Rebecca; 12 St James Street, Highgate Hill, Queensland 4101 (AU). COOPER, Mat- thew; 29 Comborne Place, Chapel Hill, Queensland 4049 (AU). ROBERTSON, Avril; 44 Maryland Street, Ken- more, Queensland 4069 (AU). SCHRODER, Kate; 7 Love Street, Fairfield, Queensland 4103 (AU). MACLEOD, Angus Murray; D6 Grain House, Mill Court, Great Shelford, Cambridge Cambridgeshire CB22 5LD (GB). MILLER, David John; D6 Grain House, Mill Court, Great Shelford, Cambridge Cambridgeshire CB22 5LD (GB). (74) Agents: ELEND, Almut et al.; Venner Shipley LLP, Byron House - Cambridge Business Park, Cowley Road, Cambridge Cambridgeshire CB4 OWZ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME 0 0 Q R 1 // w2 W 1 N N R2 H H Formula (I) (57) : The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prod - rugs thereof: Formula (I) wherein Q is selected from 0, S and Se; J is S or Se; W 1 and W 2 , when present, are independently selected from N and C; R 1 and 12 z are independently selected from the group consisting of hydrogen, C,-Cualkyl, C2-Cizalkenyl, C2- C u alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W 1 and W 2 is present and is a nitrogen atom and when R 1 and R 2 are cyclic then the respective W 1 or W 2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflam- masome mediated disorders, and to associated diagnostic uses. 111111111111110111011111111111010111110111010111111111111111 11111110111111111110111111