Patent SG-11201810605U-A (SG)
Title: Selectively altering microbiota for immune modulation
Inventor: CLUBE JASPER
IPC: A61K35/17
Filed: 2017-06-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT 1 1111111111111111110111111111111111111111111110111011111111111111111111111111111111111111111 (10) International Publication Number WO 2017/211753 Al (51) International Patent Classification: A61K 35/17 (2015.01) A61P 35/00 (2006.01) A61K 35/15 (2015.01) A61K 31/7105 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/EP2017/063593 (22) International Filing Date: 04 June 2017 (04.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1609811.3 05 June 2016 (05.06.2016) GB (71) Applicant: SNIPR TECHNOLOGIES LIMITED [GB/GB]; Kemp House 152, City Road, London London EC1V 2NX (GB). (72) Inventors: CLUBE, Jasper; Kemp House, 152 City Road, London EC1V 2NX (GB). SOMMER, Morten; Novo Nordisk Foundation Center for Biosustainability Techni- cal University of Denmark (DTU), Kogle All& 6, 2970 Horsholm Copenhagen (DK). GRONDAHL, Christian; c/o Jasper Clube, Kemp House, 152 City Road, Lon- don EC1V 2NX (GB). VAZQUEZ-URIBE, Ruben; No- vo Nordisk Foundation Center for Biosustainability Techni- cal University of Denmark (DTU), Kogle All& 6, 2970 Heir- sholm Copenhagen (DK). VAN DER HELM, Eric; No- vo Nordisk Foundation Center for Biosustainability Techni- cal University of Denmark (DTU), Kogle All& 6, 2970 Heir- sholm Copenhagen (DK). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.17(i)) Published: — with international search report (Art. 21(3)) W O 20 17 / 21175 3 Al (74) Agent: CLUBE, Jasper; Kemp House 152 City Road, Lon- don EC1V 2NX (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION (57) : The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.