baber/WOPTO huggingface dataset:
Patent CR-20140511-A (CR)
Title: Procedimiento de fabricación de una forma de dosificación farmacéutica que comprende nifedipina y candesartán cilexetilo
Inventor: FUNKE ADRIAN
IPC: A61K31/4422
Filed: 2014-11-07
Abstract: La presente invención se refiere a procedimientos de fabricación para la preparación de una forma de dosificación farmacéutica que comprende nifedipina y candesartán cilexetilo y, opcionalmente, al menos un diurético, caracterizada porque la nifedipina se libera en el organismo de una manera controlada (modificada) y el candesartán cilexetilo se libera rápidamente (liberación inmediata [LI]) y, opcionalmente, el diurético se libera rápidamente (liberación inmediata [LI]), y a las formas de dosificación farmacéuticas que se pueden obtener mediante dichos procedimientos.
Patent CR-20170438-A (CR)
Title: Desacetoxitubulisina h y análogos de esta
Inventor: NICOLAOU KYRIACOS C
IPC: A01N43/78
Filed: 2016-02-25
Abstract: En un aspecto, la presente invención proporciona análogos de tubulisina de la fórmula: en donde R1, R2, R3, R4, X1, X2, X3, y A1 son como se definen en la presente descripción. En otro aspecto, la presente invención proporciona, además, métodos para preparar los compuestos descritos en en la presente descripción. En otro aspecto, la presente invención proporciona, además, composiciones farmacéuticas y métodos de uso de los compuestos descritos en en la presente descripción.
Patent CR-20180254-A (CR)
Title: Compuestos de imino con un sustituyente de 2-cloropirimidin-5-ilo como agentes de control de plagas
Inventor: GOCKEL BIRGIT;
IPC: C07D417/06
Filed: 2016-09-29
Abstract: La presente invención se refiere a compuestos de imino de la Fórmula (I); en donde las variables son como se define en las reivindicaciones y la descripción, y sus esteroisómeros, tautómeros y sales. La invención también se refiere a composiciones agrícolas o veterinarias que comprenden tales compuestos. La invención también se refiere al uso de estos compuestos, sus estereoisómeros, tautómeros y/o sales, para combatir plagas de invertebrados. Además, la invención se refiere a métodos para combatir plagas de invertebrados, que comprenden la aplicación de dichos compuestos
Patent CR-20180613-A (CR)
Title: Gusset elemento de unión arquitectónica
Inventor: GUSTAVO CALDERÓN AGUIAR
Filed: 2018-12-20
Abstract: Esta invención es una estructura modular que por medio de vigas y columnas de tubo cuadrado, cortadas, modificadas y reforzadas en medidas y calibres en específico, son capaces de ser utilizadas en el campo de la construcción y la arquitectura para que de una manera genérica y optimizando los recursos al máximo sea capaz de servir como casa, oficina, bodega o comercio para el ser humano, de una manera segura y que cumple con los reglamentos vigentes para la seguridad humana en todos los ámbitos.
Patent CR-20220451-A (CR)
Title: Anti-cd137 antigen-binding molecule for use in cancer treatment
Inventor: ONO NATSUKI
IPC: A61P43/00
Filed: 2021-02-10
Abstract: [Problem] The purpose of the present disclosure is to provide: an anti-cancer agent having immune cell activation action, cytotoxic activity, or anti-tumor activity, and yet having little activity against non-tumor tissues such as normal tissues, and also having few side effects; a combination therapy that uses said anti-cancer agent together with other anti-cancer agents; and a pharmaceutical composition for use in the combination therapy. [Solution] Provided are: an anti-cancer agent; a combination therapy using the anti-cancer agent together with other anti-cancer agents; and a pharmaceutical composition for use in the combination therapy. This anti-cancer agent includes an anti-CD137 antigen-binding molecule according to the present disclosure as an active ingredient, where the binding activity of the molecule against CD137 varies depending on a variety of substances (e.g., low molecular compounds) on target tissues. As a result, the anti-cancer agent has immune cell activation action, cytotoxic activity, or anti-tumor activity, and yet has little activity against non-tumor tissues such as normal tissues, and also has few side effects. The anti-cancer agent is expected to be applicable to various types of cancer.
Patent CR-20220576-A (CR)
Title: Combination therapy with modified pbmcs and an immunoconjugate
Inventor: LOUGHHEAD SCOTT
IPC: C12N5/078
Filed: 2021-05-10
Abstract: The present application provides methods for stimulating an immune response in an individual comprising administering a composition of nucleated cells (e.g., PBMCs) comprising an intracellular exogenous antigen in conjunction with administering an immunoconjugate comprising a variant IL-2 polypeptide and a second polypeptide. The variant IL-2 polypeptide exhibits reduced affinity to the a-subunit of the IL-2 receptor. The second polypeptide targets a tumor cell or a T cell.
Patent EC-SP034898-A (EC)
Title: 2,5-DIARILPIRAZINAS, 2,5-DIARILPIRIDINAS y 2,5- DIARILPIRIMIDINAS
Inventor: GE PING
IPC: A61K31/497
Filed: 2003-12-12
Abstract: Se suministran compuestos de diarilpirazina, diarilpiridina y diarilpirimidina que actúan como moduladores selectivos de los receptores CRF 1. Estos compuestos son útiles en el tratamiento de un número de trastornos periféricos y del sistema nervioso central, particularmente estrés, ansiedad, depresión, trastornos cardiovasculares y trastornos de alimentación. Se suministran también métodos para tratar tales trastornos así como composiciones farmacéuticas empacadas. Los compuestos de fórmula I son también útiles para tratar de encontrar la localización de los receptores CRF y como patrones en los ensayos para unión del receptor CRF. Se suministran también métodos de uso de los compuestos en los estudios de localización del receptor.
Patent EC-SP088329-A (EC)
Title: Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8
Inventor: CONNOLLY STEPHEN
IPC: C07D471/10
Filed: 2008-03-28
Abstract: La invención provee compuestos de la fórmula general (I), en donde A, B, p, w, x, y y z tienen las definiciones indicadas en la descripción, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
Patent EC-SP930991-A (EC)
Title: Procedimiento para la obtencion de un colorante purificado de curcumina y su producto
Inventor: GUERRA MILTON
IPC: A23L5/40
Filed: 1993-10-25
Abstract: El procedimiento para obtener el colorante de curcumina mediante la extracción de los rizomas secos y molidos de Curcuma longa L. con etanol, evaporación del extracto y extracción del residuo con un hidrocarburo alifático, se mejora mediante la extracción del material que contiene la curcumina, con agua, sea antes o después dela extracción con el hidrocarburo, obteniéndose un producto mejorado fácil de manejarlo y de mayor pureza relativa.
Patent EC-SP951364-A (EC)
Title: Proceso semi-continuo para la biodegradacion intensiva de lodos aceitosos en sitio
Inventor: GROSSO VARGAS JORGE LUIS
IPC: C11B13/00
Filed: 1995-01-11
Abstract: Formación de un sistema orgánico optimizado con una concentración de hidrocarburo menor al 40%, mezclando un medio matriz o relleno con el substrato orgánico a biodegradar en una zaranda o tamiz rotatorio, en una relación preferiblemente 2.1 en un ambiente aireado, con presencia de nutrientes activos y modificadores de acidez que agilicen el proceso, hasta alcanzar una conversión del hidrocarburo en el producto mayor del 80%. Mezclado de los elementos constitutivos del sistema orgánico con los microorganismos selectivos específicos, homogeneizados, a través de una serie de tornillos sinfin, que constituyen la línea de transporte, mezclado y aireación intensiva en circuíto o proceso cerrado. Los microorganismos son incorporados mediante el rociado atomizado contínuo a través de ésta línea de producción, conversión o mezcla. Recarga del lodo aceitoso, una vez lograda la conversión o BIODEGRADACION deseada, hasta la relación originalmente propuesta.
Patent EC-SP993262-A (EC)
Title: Nuevos regimen anticonceptivo
Inventor: BENNINK COELING
IPC: A61K31/56
Filed: 1999-12-10
Abstract: La invención está dirigida a unidades de dosificación farmacéuticas y también a un kit anticonceptivo. Se describe un régimen anticonceptivo bifásico sin un intervalo libre de hormonas. El régimen tiene 28 dias e involucra la administración diaria secuencial de únicamente estradiol durante los primeros doce a dieciséis días, y un progestágeno, a saber (17a) -17-hidroxi-11-metyilen-19-norpregna-4,15-dieno-20-in-3-ona (ORG 30659) junto con estradiol durante los doce a dieciséis dias siguientes, depués de lo cual la primera fase del ciclo siguiente comienza sin una pausa ni placebo. El orden de las fases también puede ser invertido.
Patent FI-20045280-A (FI)
Inventor: KURKINEN LEO
IPC: D21F5/02
Filed: 2004-07-28
Abstract: The invention relates to a roll for a web forming machine. The roll includes a shell (10), with end pieces (11) at both ends of it. The end pieces (11) are arranged to be detachably attached to the shell (10), and in each end piece (11) there is an end plate (13) with a protruding shaft (14) in it. The end piece (11) includes a separate inner piece (17), in which there is an internal hole (18) corresponding to the protruding shaft (14) for attachment. In the inner piece (17) the end plate (13) is supported by at least one plate piece (19). The invention also relates to a method for manufacturing the roll for a web forming machine.
Patent FI-20051237-A (FI)
Inventor: MONONEN SAKARI
IPC: A01G/
Filed: 2005-12-01
Abstract: The present invention relates to an apparatus for treatment of stumps, and particularly, for cutting up, extracting and cleaning tree stumps, comprising a stump extraction grapple (3) mounted onto a turning device (2) attached to the basic machine crane (I), the frame (4) of said grapple comprising stump-splitting blades (6) with a sharpened leading edge attached by articulated joints (5), the first set of actuators (7) for turning the stump-splitting blades (6) for the purpose of splitting the stump in between, extraction arms (10) mounted onto the stump-splitting blades (6) for pulling out stumps, and second set of actuators (9) for operating the extraction arms. In the apparatus according to the invention surface plates (8) are attached to the lower edge of the stump-splitting blades (6), and compression arms (11) are attached to the frame (4), with said arms having a sharpened leading edge to split the stump, and to which compression arms (11) are attached holding arms (14). Furthermore, the apparatus includes a third set of actuators (13) to turn the compression arms, said compression arms (11) and holdings arms (14) are arranged to press the stump parts against the angle formed by the cutting blades (6) and the surface plates (8) for the duration of the extraction, lifting, and cleaning of tree stumps.
Patent FR-1604782-A (FR)
Title: Sedimentation classifier - using sealed settling tanks fed with supplementary liquid
IPC: B03B5/60
Filed: 1967-11-28
Granted: 1972-01-31
Abstract: A classifying appts. to separate e.g. sand into fine intermediate, and coarse fractions, has a settling tank in two adjacent pyramidal units sealed from the atmosphere, each of which is connected to a hydrocyclone separator. Slurry is fed at one end through a horizontally diffusing nozzle, below which supplementary water is introduced at a rate which may be varied by a valve. Supplementary water may also be introduced using the same pump at the outlets to the two hydrocyclones, and controlled by valve to vary fraction mix. The appts. is esp. applicable with suction dredged sand, and will handle up to 600 tons/hr. in a space 8m x 2.6 m. x 3.5 m.
Patent GB-1016046-A (GB)
IPC: D07B3/00
Abstract: 1,016,046. Twisting wires. KABLO KLADNO, NARODNI PODNIK. Feb. 21,1964 [Oct. 21, 1963], No. 7298/64. Heading DlT. A twisting machine for the production of wire ropes from a supply source 1 outside the twisting machine comprises a first hollow twisting spindle 4 extending into and rotating with a first chamber 6, such that the wires can be drawn through the twisting spindle 4 and deposited on the inner circumference of the chamber 6 by the action of both centrifugal force and Coriolis acceleration; and a second hollow twisting spindle 9 extending into and rotating with a second chamber 8 such that twisted wires 10 in the chamber 8 can be drawn through the twisting spindle 9, to change the twisting pitch to the desired value, and on to a take up spool 18 mounted outside the twisting machine. The chambers 6 and 8 are alternately filled with and discharged of the rope by turning the arm 7 to align the chambers with the appropriate twisting spindle. In the first twisting spiddle 4 the basic twist is imparted to the rope which in the second twisting spindle 9 the basic twist is reduced to the desired value. A traversing device 5 oscillates the twisting tube 4 to distribute the twisted rope in the chamber 6. The machine includes a drawing device 20 with a rubber pressing roller for imparting a constant advance velocity to the rope elements 2 entering the twisting spindle 4; and a take-off device 17 for drawing rope out through the twisting spindle 9, the devices 20 and 17 being coupled together to rotate at equal speeds. The spindles 4 and 9 are coupled by non- slipping gears 14,14<SP>1</SP> with an interposed non- slipping variator 15 the preset gear ratio of which defines the resultant twisting pitch of the rope 16.
Patent GB-1050490-A (GB)
IPC: F42C13/08
Abstract: 1,050,490. Projectile fuzes. J. PETERS. Dec. 18, 1962 [Dec. 23, 1961], No. 47719/62. Heading F3A. A magnetic proximity fuze which responds to changes in the magnetic field resulting from the superimposition of the magnetic field due to ferromagnetic components of a target on the earth's magnetic field comprises three coils perpendicular to one another, the voltages e x , e y , e z  induced in which as a missile containing the fuze approaches the target being fed to amplifiers 25, 26, 27 and then to multipliers 45, 46, 47 where each amplified signal is multiplied by its time integral from integrators 35, 36, 37, the outputs from the multipliers being fed to a common summator 30 which is followed by a further summator 34 in which the time integral from an integrator 31 is added to the output of summator 30 to produce a voltage at the output 40 proportional to |M|<SP>2</SP>+b. d/dt | M |<SP>2</SP>, where " M " is the change of field intensity and "b" a coefficient introduced by a stage 33 in parallel with the integrator 31. Output 40 leads to an electronic switch in which a desired threshold value for the ignition voltage can be adjusted. This switch, which is not absolutely necessary, is followed by the actual fuze. The voltage at the output 40 follows curve 3 (Fig. 6) and is the sum of curve 1, which shows the square of the modulus of the change of field intensity, and curve 2,which gives the differential coefficient with respect to time of this modulus. By suitably choosing coefficient " b " and release threshold 4, the release pulse which causes the ignition of the explosive charge can be advanced to time "t 1  " so that the actual ignition will occur only at time "t 2 " due to the ignition delay, while the nearest approach to the target is reached at time "t 3 " when curve 1 has its peak.
Patent GB-1050511-A (GB)
IPC: C07G11/00
Abstract: 1,050,511. Antibiotics MM. 18 and MM. 22. IMPERIAL CHEMICAL INDUSTRIES Ltd. Jan. 25, 1965 [Feb. 14, 1964], No. 6269/64. Heading C2A. Antifungal antibiotics MM. 18 and MM. 22 are produced by the cultivation of Helminthosporium dematioideum (I.M.I. 74812) in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen. MM.18 and MM. 22 present in the culture filtrate may be isolated by filtration of the culture medium followed by extraction of the filtrate with chloroform, separation is obtained by chromatography using an absorption column of silica gel or alumina and eluting with benzene-chloroform (MM. 18) followed by chloroform (MM. 22). MM.18 has the formula C 29 H 35 NO 5 , M.P. 182- 185‹ C., sometimes 189-192‹ C. and an I.R. absorption spectrum which shows V max. (liquid paraffin): 3350(s), 3210(m), 3140(w), 3060(vw), 1714(vs), 1692(s), 1623(w) and V max. (bromoform) : 3570(w), 3410(w), 3040(w), 3030(sh), 1717(s), 1695(m), 1625(w), it forms a mono-acetate of M.P. 176-181‹ C. MM. 22 has the molecular formula C 29 H 37 NO 5 , M.P. 218-221‹ C., with an I.R. absorption spectrum which shows V max. (liquid paraffin): 3510(w), 3380(s), 3225(w). 3155(w), 3100(w), 3030(vw), 1715(vs), 1692(vs), 1638(w), 1605(w) and V max. (bromoform): 3520, 3410, 3300, 1712(s). Oxidation of MM. 22 with CrO 3  in the presence of pyridine or MnO 2  in the presence of chloroform gives MM.18. Reduction of MM. 18 with an equivalent amount of sodium borohydride in the presence of methanol gives MM. 22.
Patent GB-1225851-A (GB)
IPC: F16L3/233
Filed: 1968-08-02
Abstract: 1,225,851. Releasable fastenings. ILLINOIS TOOL WORKS Inc. 2 Aug., 1968 [7 Aug., 1967], No. 37077/68. Heading E2B. A one-piece strap device comprises a body section through which is a passage defined by surrounding walls, including opposite first and second walls 82, 84, and a flexible strap section 32 extending from the second wall 82, the strap section including a free end and a portion 60 bearing a plurality of teeth 76 spaced along one side of the strap section, the body section including a detent 98 carried by the first wall 84, and a tap 100 carried by the second wall 82, the detent being substantially rigid in position relative to the passage, the detent and the teeth being of complementary shape such that when the free end of the strap section is passed through the passage in the appropriate direction for a sufficient distance, the detent engages one of the teeth in a manner resisting withdrawal of the strap section, the tab being resiliently flexible and having an unstressed shape such that, when the detent engages one of the teeth, the presence of the strap section in the passage deflects the tab, and the consequent stress in the tab urges the strap section towards the first wall and the detent, while permitting the strap section to be disengaged from the detent upon application of sufficient force to deflect the tab further, and the first wall having a substantial area of surface for engagement by the strap section when present in the passage, to maintain the alignment of the strap section in the passage. In the construction shown a shank 26 extends outwardly from the body section to enable the body section to be engaged with an aperture in a mounting panel 22 the shank having shoulders 38, 40 for engaging the opposite side of the mounting panel for that engaged by the body section. The body section is provided with a pair of flanges 34, 36 which extends outwardly from the body section for resilient engagement with the panel to maintain the shoulders 38, 40 in engagement with the undersurface of the panel. The strap in addition to a free end portion 56 and the portion 60 having the teeth 76 has a portion 58 between the portion 56 and the portion 60 which is thinner than the adjacent end of the portion 56 and connected to it by a ramp 104, this ramp 104 co-operates with the detent 98 to secure the strap section against displacement in a position in which a loop is sufficiently large to accommodate loosely electric conductors while they are being positioned within the loop. In a modification the shank 26 and the flanges 34, 36 are omitted and the clamp is intended for binding the conductors together as a group without mounting them upon a panel.
Patent GB-1225963-A (GB)
IPC: H01H19/635
Filed: 1967-02-27
Abstract: 1,225,963. Actuation of switches. MIDLAND ELECTRIC MFG. CO. Ltd. 14 March, 1968 [27 Feb., 1967], No. 9182/67. Heading H1N. A motor isolator switch has a slidable contact carrier 12 provided with limbs 12e mounting a rod 13, a first cam 14 being disposed between the limbs 12e and extending between a cross-bar 12a of the carrier and rod 13, and a second cam 16 extending on the other side of rod 13. A post (14b, Fig. 2) and a notch (14c) on cam 14 and a notch (16b, Fig. 2) and a post (16c) on cam 16, respectively interfit so the two cams rotate as a unit, diametrically opposed pairs of cam surfaces 14a and 16a forming a pair of helical cam slots coacting with rotatable anti-friction sleeves 15 on rod 13. Posts (14b, 16c) coact with fixed stops 17 to limit angular movement of the cams. Contact carrier 12 has three movable contacts 12c which co-operate with three pairs of fixed contacts in base 10, and plungers 12d which coact with plungers of two auxiliary switches in base 10, as in Specification 1,135,751. A spigot 18 on cam 16 has recesses 18a into which rollers 20 mounted on pivoted links 21 are urged to bias the cams to their limiting positions. A stem 19 on cam 16 coacts with a slot in the spindle 25 of an operator 22 mounted on a hinged or removable cover 23. A plate 26 on cover 23 has a slot 26a that can fit over the head of stem 19 when the cams are positioned such that contacts 12c are spaced from the fixed contacts. When the cams are rotated through 90 degrees and contacts 12c bridge the fixed contacts, and the head of stem 19 interferes with plate 26 and prevents removal of cover 23. A member 27 on spindle 25 and a leaf-spring 28 on plate 26 bias operator 22 to either of its stable positions.
Patent GB-1227071-A (GB)
IPC: C12C1/067
Filed: 1969-04-18
Abstract: 1,227,071. Malting. NORDEN ET CIE. April 18, 1969 [April 19, 1968], No.20032/69. Heading C6E. [Also in Division F4] Malting apparatus has perforated treatment floors 2, Fig.5, horizontal levelling blades 5 for the grain 8, rotational about a vertical axis, and conduits for the passage of air. The levelling blades and associated motor 11 and gears 12, are supported from a beam 7 and the beam is suspended at a required height by cables 9. Air for the germinating or drying encounters a heat exchanger 15, passes upwardly through the grain and is exhausted by a fan 20. The air may, however, be blown through the grain. Shutters 18 and 19 provide for the circulation of the air through jacketing 17. The apparatus may be of elongated or oval section, or of the shapes depicted in Figs.3 and 4. Charging and discharging of the grain may take place continuously.
Patent GB-1227546-A (GB)
IPC: H01L21/10
Filed: 1968-08-27
Abstract: 1,227,546. Vacuum deposition of photoconductive layer. RANK XEROX Ltd. Aug.27, 1968 [Aug.29, 1967], No.40813/68. Heading C7F. [Also in Division H1] A photo-conductive layer 1-300 microns thick is formed by vacuum depositing a Se-As alloy containing 5-900 parts per million of a halogen on to a substrate maintained at 25‹-50‹C. throughout the deposition. The substrate may be Cu, Al, Fe, brass, metallized paper, plastics coated with Al or copper iodide, or glass coated with Cr or tin oxide. The Se-As alloy contains 0À1-50% As, preferably 0À1-2À5%; 10-250 parts per million chlorine, or 35-900 parts per million iodine, or 20-575 parts per million bromine. The substrate may be in the form of a rotating drum which is water cooled to maintain the temperature of 25‹ -50‹ C. and the evaporation boat may be of quartz, molybdenum or stainless steel coated with SiO. The substrate may also be a sheet, web, plate or cylinder and if the coating is formed on an insulating substrate it may be electrostatically charged by moving it between two corona charging devices. The process is used to produce xerographic plates.
Patent GB-1232185-A (GB)
IPC: E21B10/44
Filed: 1969-12-08
Abstract: 1,232,185. Drills. A. FISCHER. 8 Dec., 1969 [21 Dec., 1968], No. 59712/69. Addition to 1,198,318. Heading B3C. [Also in Division F2] A fastening device as disclosed in the parent Specification is modified by providing the fixing element 1 with helical grooves 10 extending from the flat tapered surfaces 4 at one end 2 of the element 1 towards the other end of the element.