baber/WOPTO huggingface dataset:
Patent CA-2286580-A1 (CA)
Title: Adenoviral vectors comprising a modified e4 region but retaining e4orf3
Inventor: KAPLAN JOHANNE
IPC: A61K48/00
Filed: 1998-04-14
Abstract: The present invention relates to transgene expression systems, related compositions comprising the transgene expression systems, and methods of making and using them. Preferred systems employ an adenovirus transgene expression vector comprising DNA encoding a transgene which codes for a desired product operably linked to expression control sequence, and at least a portion of the adenovirus E3 region and certain portions of the E4 region. The E4 portions comprise the open reading frame sequence known as E4ORF3 and at least one other portion of E4. Preferably the E4 portion of the vector (or "E4 cassette") includes E4ORF3 and at least one other portion selected from E4ORF4, E4ORF6/7 and E4ORF3/4. The invention has a number of important features including improving persistency of transgene expression in a desired host cell. The transgene expression systems of the present invention are useful for a variety of applications including providing persistent cellular expression of the transgene in vitro and in vivo.
Patent CA-2287849-A1 (CA)
Title: Procede de granulation d'aerogels
Inventor: SCHMIDT MARC
IPC: B01J13/00
Filed: 1998-04-29
Abstract: L'invention concerne un procédé d'agglomération de particules d'aérogel dans lequel les particules d'aérogel sont introduites dans un dispositif de mélange et mélangées, un liant étant amené dans le dispositif de mélange.
Patent CA-2288839-A1 (CA)
Title: An improved heat exchanger for operating with a combustion turbine in either a simple cycle or a combined cycle
Inventor: WILLIS SCOTT CUTLER
IPC: F01K23/10
Filed: 1999-03-01
Abstract: This invention includes a heat exchanger that can be operated with a combustion turbine. This heat exchanger can be operated in either a simple cycle mode of operation or a combined cycle mode of operation. Preferably, the heat exchanger has a first heat transfer stage (44), a second heat transfer stage (50), a bypass stack and a damper (46). The damper (46) and the bypass stack (48) are preferably disposed between the first and the second heat transfer stages. Hot fluid can be received into the heat exchanger from the combustion turbine (14) and directed through the heat transfer stages (44, 50) where heat is transferred from the hot fluid to the cooling medium flowing through the tubes of the heat transfer stages (44, 50). Preferably, the hot fluid enters the heat exchanger upstream of the first heat transfer stage (44). After flowing through the first heat transfer stage, the hot fluid can be directed by the damper (46) to either the bypass stack (48) or the second heat transfer stage (50). The damper may have at least two positions which include a first position and a second position. In the first position, the hot fluid exiting the first heat transfer stage is directed through the bypass stack and does not enter the second heat transfer stage. After flowing through the bypass stack, the hot fluid exhausts to atmosphere. In this position, the heat exchanger is operated in a simple cycle mode of operation. Conversely, when the damper is in the second position, hot fluid exiting the first heat transfer stage (44) is directed to the second heat transfer stage (50) and not through the bypass stack (48). In this position, steam for operating a steam turbine (32) is produced, and the heat exchanger is operated in the combined cycle mode of operation. In either position, steam can be extracted from the heat exchanger for cooling components of the combustion turbine or for power augmentation of the combustion turbine.
Patent CA-2291593-A1 (CA)
Title: Ingot mould head for continuous vertical load casting of elongated flat metal products
Inventor: PERRIN ERIC
IPC: B22D11/04
Filed: 1998-05-26
Abstract: In this type of mold, a feed head (23) made of thermally insulating refractory fits on top of the cooled copper crystallizer (7) being internally aligned with it in order to define a passage for the cast metal, with interposition between the two of an insert (24) made of dense refractory having mechanical strength properties. This insert (24) consists of bars, each bar (29) being formed by a rigid assembly of aligned and juxtaposed contiguous elements (30) kept clamped against each other by a clamp incorporated into the bar, such as a cross-tie (31) associated with compression pads (33), and positioning and aligning the bar on the crystallizer (7) are provided and consist of a battery of spring pushers (38), which battery is associated with a positioning stop (39) on the crystallizer against which the bar (29) presses.
Patent CA-2292073-A1 (CA)
Title: Method for separating co2 from waste gases, converting it to ch4 and storing both outside the atmosphere and methane produced by this method
Inventor: WILD WERNER
IPC: F17C1/00
Filed: 1999-12-13
Abstract: The CO2 is separated from waste gases by known technical means and stored in the underground (see drawing). By additions to the CO2, according to the invention, of H2 or NH3, methano-genic bacteria, bacteria substrate, catalysators and/or inhibitors the CO2 is reduced during the underground sto-rage to CH4. The storage is possible in aquifers, natural gas reservoirs or oil and/or gas generating rock formations. Due to the equal volumes of CO2 and CH4 the process is a closed cycle and of constant pressure. Natural gas becomes a renewable energy.
Patent CA-2293075-A1 (CA)
Title: Friction resistance generator
Inventor: MIMURA KENJI
IPC: F16D7/00
Filed: 1999-12-23
Abstract: The present invention relates to a friction resistance generator capable of always generating a stable frictional force even if the opposed surfaces of a rotary member and a passive member have a curved shape such as a circumferential surface or a spherical surface. In the present invention, when the rotary member is rotated in the predetermined direction while a load is applied to the passive member, the rollers supported rotatably on one of the rotary member and the passive member rotate while being in contact with the rotary member or the passive member, thereby generating a frictional force according to the load on the rollers. In this case, the rollers are installed rotatably on either one of the opposed surfaces of the rotary member and the passive member, and the rollers are arranged so as to be capable of coming into contact with the other of the opposed surfaces of the rotary member and the passive member.  Therefore, the rollers can be formed so as to rotate while being in contact with only either one of the rotary member and the passive member, so that the present invention can be applied to the apparatus in which the opposed surfaces of the rotary member and the passive member have a curved shape such as a circumferential surface or a spherical surface.
Patent CA-2293252-A1 (CA)
Inventor: FRATER GEORG
IPC: A23L27/00
Filed: 1998-06-22
Abstract: L'invention concerne des composés de la formule (I) dans laquelle n désigne 1, 2 ou 3 et R?1¿ à R?6¿ représentent indépendamment des radicaux alkyle, alcényle, alcynyle, cycloalkyle, cycloalcényle, ou aromatiques, ramifiés ou non ramifiés, substitués ou non substitués, ou de l'hydrogène, ces radicaux pouvant contenir en outre un ou plusieurs groupes - O - et/ou - (a), un ou deux noyaux pouvant être formés par combinaison de R?1¿ à R?6¿ respectivement et ce/ces noyaux pouvant être substitués par un groupe alkyle dans lequel soit X représente O et R?7¿ représente un radical d'un alcool ou d'un phénol R?7¿OH soit X représente N et R?7¿ représente le radical d'une amine R?7'¿R?7"¿NH, R?7'¿ et R?7"¿ représentant indépendamment des radicaux alkyle, alcényle, alcynyle, cycloalkyle, cycloalcényle ou aromatiques ou alors R?7'¿R?7"¿ peuvent désigner un hydrogène, auquel cas l'amine est une amine parfumée ou l'amine renferme plus de 9 atomes de C, auquel cas R?7¿ de l'alcool ou du phénol et R?7'¿ et/ou R?7"¿ de l'amine respectivement peuvent contenir également au moins un reste C(OH)R?1¿R?2¿-CR?3¿R?4¿-(CR?5¿R?6¿)¿n?-CO- de la formule (I); ces composés s'utilisent comme précurseurs dans la diffusion de composés odorants et/ou antibactériens dans des compositions cosmétiques, des produits cosmétiques, des désodorisants, des agents de nettoyage de surfaces dures ou des produits de lessive.
Patent CA-2294191-A1 (CA)
Inventor: SATOI KATSUYUKI
IPC: A62C8/06
Filed: 1999-04-16
Abstract: A sheet for preventing burning by spreading fire which comprises a water-absorptive polymer material layer being capable of absorbing sprayed water and has flexibility sufficient to change the form thereof corresponding to that of an object with which the polymer layer is in contact. When there is a danger of burning by spreading fire, this sheet can be used for cutting off an object from the fire and preventing the object from burning by rendering the water-absorptive polymer material layer contained therein to absorb an abundance of water and form a water-containing layer. A sheet and a cover for preventing burning by spreading fire, and a combined fire-extinguishing sheet and disaster-preventing clothing which comprises a surface side comprising a water-absorptive polymer material layer forming a water-containing layer, and, laminated therewith, a back side comprising a substrate having functions of fire resistance, heat resistance, insulation, waterproof, elasticity and protection are also provided. They exhibit an enhanced effect of preventing burning by spreading fire and can protect an object with improved reliability.
Patent CA-2298245-A1 (CA)
Title: Matrix controlled release device
Inventor: NIGHTINGALE JAMES ALAN SCHRIVE
IPC: A61P25/16
Filed: 2000-02-09
Abstract: There is disclosed a controlled release dosage form for a low solubility drug that is a spray-dried or spray-coated amorphous solid dispersion of the drug in an ionizable cellulosic polymer matrix that is in turn incorporated into a secondary erodible polymeric matrix and a method of treating a disease or disorder comprising administering such a dosage form.
Patent CA-2298289-A1 (CA)
Title: Determining transmit signal powers of channels in a cdma communications system
Inventor: WANG RUI R
IPC: H04B1/707
Filed: 2000-02-11
Abstract: A plurality of data channels provide respective data rates and maximum error rates from a mobile station to a base station of a CDMA system; a pilot channel facilitates recovery of the data channels. For each data channel there is determined a channel energy to noise ratio (ENR) and a required pilot channel ENR. A maximum one of the required pilot channel ENRs is selected as an ENR for transmission of the pilot channel. A relative gain, and hence transmit signal power, for each data channel is determined from the ENR determined for the data channel and the selected maximum ENR for transmission of the pilot channel, thereby minimizing the total transmitted signal power of the mobile station. The data channel signals are spread using orthogonal Walsh codes and are combined with their determined relative gains.
Patent CA-2300138-A1 (CA)
Inventor: KORSFELDT DAN
IPC: H03B28/00
Filed: 1998-06-30
Abstract: The present invention is related to a digital oscillator (400) for use in a radio receiver (110). The oscillator comprises a signal generator (401), generating a digital sinusoidal signal (S43). The digital sinusoidal signal (S43) is fed into phase shifting means (402) being separate from the signal generator (401). The phase shifting means (402) derives from the digital sinusoidal signal (S43) a first pair of digital sinusoidal signals (S44, S45) having a phase difference corresponding to at least one sample step. The first pair of digital sinusoidal signals (S44, S45) is fed into orthogonalization means (403) which produces a pair of orthogonal digital sinusoidal signal (S41, S42) by forming linear combinations of the first pair of digital sinusoidal signals (S44, S45).
Patent CA-2300747-A1 (CA)
Inventor: LI JINGHUI
IPC: H04B10/17
Filed: 2000-03-15
Abstract: An in-line repeater implemented within a Wavelength Division Multiplexed (WDM) optical fiber communication system is shown that includes an attenuator.      The communication system includes a WDM multiplexer that transmits a WDM signal including a series of WDM channels, via the in-line repeater, to a demultiplexer that separates the WDM channels into a series of output signals. Within the in-line repeater, the attenuator is coupled between two stages of a single amplifier in order to aid in the power equalization of the WDM channels at the demultiplexer. The addition of the attenuator results in the powers and OSNR of the individual WDM channels becoming closer in value, hence reducing the time and the dynamic range of transmitter power adjustments required for traditional methods to equalize the channels' powers.
Patent CA-2301967-A1 (CA)
Title: Azetidinone derivatives for the treatment of hcmv infections
Inventor: O'MEARA JEFFREY
IPC: A61K31/4178
Filed: 1998-10-06
Abstract: Compounds of formula I:   (see formula I) wherein R1 is hydrogen, methyl, ethyl, methoxy or methylthio; R2 and R3 each independently is hydrogen or C1-3 alkyl; R4 is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; R5 is lower alkyl, lower cycloalkyl, (CH2)m C(O)OR6 wherein m is the integer 1 or 2 and R6 is lower alkyl, phenyl optionally substituted with C(O)OR7 wherein R7 is lower alkyl or phenyl(lower alkyl); or R6 is Het or Het(lower alkyl; or R4 and R5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with benzyloxycarbonyl or with phenyl optionally substituted among other group with C(O)OR7 wherein R7 is lower alkyl or (lower alkyl)phenyl; X is selected from the group consisting of O, S, SO, SO2, NR8, wherein R8 is H or lower alkyl; and Y is C1-10 non-cyclic or cyclic alkyl; [(CH2)0-1]-phenyl, said phenyl ring optionally substituted; Het or Het(lower alkyl); or when X is NR8, wherein R8 is lower alkyl and Y is lower alkyl or lower alkoxy, X and Y are joined together to form a morpholino or piperidino ring; or a therapeutically acceptable acid addition salt thereof, are described as useful against human cytomegalovirus infection.
Patent CA-2305865-A1 (CA)
Title: Molten pump with monolithic rotor and rigid coupling
Inventor: COOPER PAUL V
IPC: F16D1/02
Filed: 1999-08-11
Abstract: A device for pumping molten metal that eliminates rotor bearing members comprises a pump having a pump chamber (26) including a first bearing surface (62A), and a monolithic rotor (100) having a second bearing surface (200) that aligns with the first bearing surface (62A). The second bearing surface (200) is formed of and integral with the material forming the rotor (100).  Preferably a rigid rotor shaft (38) to motor shaft (70) connection is utilized to rigidly center the rotor within the pump chamber and, hence, within the first bearing surface (62A).
Patent CA-2306513-A1 (CA)
Title: Medical suctioning apparatus and methods of use
Inventor: EPSTEIN GORDON HOWARD
IPC: A61B17/00
Filed: 1998-04-14
Abstract: A medical fluid suction device for selectively applying varied levels of suction pressure at a device tissue interface includes a direct "trumpet" type control mechanism in conjunction with a "venturi" type control.  A valve manifold (300) is adapted to couple a vent pathway and a suction pathway (260) simultaneously to the vacuum conduit adapted for connection to a vacuum source. The amount of resistance to flow due to vacuum pressure is adjusted simultaneously in both the vent pathway and the suction pathway (26) in order to achieve controlled, selected levels of suction. Similarly shaped valve apertures are provided in inverse and reciprocal orientation along an axis of motion of a valve manifold (300).
Patent CA-2307610-A1 (CA)
Title: A lifting device with a liftable and tiltable platform
Inventor: EDMO TORBJORN
IPC: B66F7/22
Filed: 1998-09-24
Abstract: A lifting device (1) having a liftable and tiltable platform (2) for pallets or any other arbitrary load preferably has floor-supported frame (3). The lift arm (4) provided with a cylinder unit (4a, 4b) and the tilt arm (12) provided with a cylinder unit (12a, 12b) are each at the one end pivotable around the same shaft (5). The lift arm (4) is connected to a link arm (7) via a pivot (6) between its point of connection (8) with the frame and a connection point (9) with a mounting piece (10) projecting downwards from the load platform. Also the tilt arm is connected thereto in a pivot point (13). In the lower position of the platform (2) link arm (7) and tilt arm (12) extend substantially horizontally and parallel to each other, the link arm (7) uppermost. The central load-receiving portion (2a) of the load platform (2) can, when the lifting device is in its lower position, be located roughly level with or insignificantly above the floor surface, whereas the lift and tilt arms are housed within portions (2b, 2c, 2d) of the platform and with inverted U-shape. In an upper position the load platform can be tilted downwards about 45° and upwards about 5°.
Patent CA-2307934-A1 (CA)
Title: Improved fuel filling point
Inventor: DAVIES ANTHONY
IPC: B60K15/04
Filed: 2000-05-09
Abstract: A fuel filling point arrangement is provided which is particularly suitable for marine vessels. The arrangement has a fuelling aperture connected via a fuelling conduit to a fuel tank of a marine craft, with an overflow pocket provided below the aperture so as to collect fuel overflow. A draining aperture is provided at the bottom of the overflow pocket for draining accumulated fuel to the outside of the craft or to an overflow tank.
Patent CA-2308871-A1 (CA)
Title: Micro-composants du type micro-inductance ou micro-transformateur, et procede de fabrication de tels micro-composants
Inventor: VALENTIN FRANCOIS
IPC: H01F17/00
Filed: 2000-05-11
Abstract: Procédé de fabrication d'un micro-composant électrique tel que microinductance ou micro-transformateur, incluant au moins un bobinage, et comprenant une couche de substrat, caractérisé en ce qu'il comprend les étapes suivantes consistant - à graver sur le substrat une pluralité de canaux disposés de façon ordonnée selon une bande (3), et orientés sensiblement perpendiculairement à ladite bande (3) ; - à déposer par électrolyse, du cuivre dans lesdits canaux de façon à former une pluralité de segments (7) ; - à planariser la face supérieure du substrat et de la pluralité de segments (7) ; - à déposer au-dessus dudit substrat (1) et desdits segments (7), au moins une couche destinée à former un noyau; - à graver le noyau pour ne le conserver qu'au-dessus de ladite bande; - à déposer par électrolyse au-dessus du noyau (15), une pluralité d'arches (18), chaque arche reliant une extrémité d'un segment (7) avec une extrémité d'un segment adjacent, en passant au-dessus dudit noyau.
Patent CA-2314259-A1 (CA)
Title: Multicatalytic protease inhibitors for use as anti-tumor agents
Inventor: SIMAN ROBERT
IPC: A61K31/4035
Filed: 1998-12-15
Abstract: The present invention relates to methods for the use of specified inhibitors of multicatalytic protease (MCP) for use as inducers of programmed cell death (i.e., apoptosis) in tumor cells, and more particularly as anti-tumor agents. The present invention provides methods for inducing apoptosis in transformed cells, inhibiting proliferation of transformed cells, and inhibiting the growth of tumors using the MCP inhibitors.
Patent CA-2315829-A1 (CA)
Inventor: CLARK ABBOT F
IPC: A61K31/573
Filed: 1998-12-07
Abstract: Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.
Patent CA-2317120-A1 (CA)
Inventor: SCHROIT ALAN J
IPC: A61K39/385
Filed: 1998-12-31
Abstract: L'invention concerne des procédés et des compositions pour prévenir et traiter les cancers à l'aide de compositions de conjugats de protéines supports de lipides permettant de générer des réponses immunitaires spécifiques aux lipides chez un animal. L'invention décrit également des procédés pour fabriquer des compositions de conjugats de phosphatidylsérine et leur formulation. Ces compositions sont prévues pour être utilisées dans diverses applications pharmaceutiques, y compris pour détecter et traiter diverses variétés de cancers et de conditions apparentées.
Patent CA-2318654-A1 (CA)
Title: Method of protecting spinal area
Inventor: GEISTLICH PETER
IPC: A61L31/04
Filed: 2000-09-12
Abstract: A method of protecting a spinal area of a patient includes the step of positioning a sheet of collagen membrane material so as to surround at least a portion of a patient's spinal chord.
Patent CA-2320271-A1 (CA)
Title: A catalyst for the (co)polymerisation of ethylene and a method for the preparation thereof
Inventor: FOLLESTAD ARILD
IPC: C08F4/6592
Filed: 1999-02-09
Abstract: A particulate, modified chromium oxide catalyst for the polymerisation of ethylene or ethylene with .alpha.-olefins, comprising: a) a chromium-oxide catalyst, b) a transition metal compound, and c) a catalyst activator. A method for the preparation of the catalyst comprises the steps of: a) subjecting a chromium oxide catalyst precursor, which comprises a chromium oxide compound combined with an inorganic support, to a temperature in the range of from 400 to 950  C  under oxidising conditions, and b) impregnating the obtained chromium catalyst with a catalyst activator and with a transition metal compound which comprises at least one cyclopentadienylic ring bonded to said transition metal and at least ligand selected from the group comprising alkoxy, amido and hydrocarbyl radicals, halogen and hybride bonded to said transition metal, which cyclopentadienylic ring may contain hetero atoms, be unsubstituted or substituted, be bonded to said transition metal through a bridge, and optionally annealed to other substituted or unsubstituted ring structures, and if two cyclopentadienyl rings are present they may be bonded to each other through a bridge, and c) subjecting the thus obtained particulate catalyst to drying conditions. This catalyst is suitable for producing polyethylenes under conditions of continuous feeding of all reactants.
Patent CA-2321478-A1 (CA)
Title: Method and device for cryptographic processing with the aid or an elliptic curve on a computer
Inventor: GEORGIADES JEAN
IPC: H04L9/30
Filed: 1999-02-02
Abstract: In elliptic curve cryptographic processing, the elliptic curve parameters are stored in the memory of a computer. These parameters are considerably long. In order to reduce the length of at least one parameter while maintaining a high degree of security, the elliptic curve is transformed. A parameter is shortened, preferably to 1, -1, 2 or -2, while the other parameters are several hundred bits long. Precisely in the case of chip cards, which have little storage space, even a single shortened parameter can already have a distinct effect.
Patent CA-2321524-A1 (CA)
Title: Low voc, isocyanate based aqueous curable compositions
Inventor: LEY DAVID
IPC: C08F2/32
Filed: 1999-01-27
Abstract: Provided is a low volatile organic content (VOC), isocyanate based curable oilin-water emulsion of a polyisocyanate crosslinker and a surface active isocyanate reactive material in an aqueous medium, and a process for the preparation thereof. Also provided is a water-in-oil intermediate product to which an aqueous medium can be added to produce the curable oil-in-water emulsion. Such curable emulsions are particularly suited for use in coatings applications.