baber/WOPTO huggingface dataset:
Patent MX-2022007993-A (MX)
Title: Pyridazinyl thiazolecarboxamide compound.
Inventor: WATANABE HIDEYUKI
IPC: A61P35/00
Filed: 2020-12-24
Abstract: Provided is a compound that is useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors studied compounds being useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy and confirmed that a pyridazinyl thiazolecarboxamide compound has an effect of inhibiting DGKÎ¶ (DGKzeta) to thereby complete the present invention. The pyridazinyl thiazolecarboxamide compound of the present invention has an effect of inhibiting DGKÎ¶ and is usable as a therapeutic agent for cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.
Patent MX-2022008602-A (MX)
Title: Polynucleotides encoding interleukin-12 (il12) and uses thereof.
Inventor: FREDERICK JOSHUA
IPC: A61K38/20
Filed: 2018-11-05
Abstract: The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides.
Patent MX-2022009018-A (MX)
Title: Lipid nanoparticles.
Inventor: DE KOKER STEFAAN
IPC: A61K9/00
Filed: 2021-01-21
Abstract: The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.
Patent MX-2022009415-A (MX)
Title: Drive circuit for a light-emitting diode light source.
Inventor: DEJONGE STUART W
IPC: H05B45/325
Filed: 2021-01-29
Abstract: A controllable lighting device may comprise a drive circuit characterized by one or more cycles and a control circuit configured to control the drive circuit to conduct a load current through a light source of the lighting device. The control circuit may be configured to determine one or more operating parameters of the lighting device during a present cycle of the drive circuit based on a feedback signal indicative of a peak magnitude of the load current conducted through the light source. The control circuit may be able to adjust an average magnitude of the load current conducted through the light source so as to adjust an intensity of the light source towards a target intensity based on the operating parameters.
Patent MX-2022012971-A (MX)
Title: Compositions containing thermally conductive fillers.
Inventor: NAKAJIMA MASAYUKI
IPC: C08J3/20
Filed: 2021-04-14
Abstract: Disclosed herein is a moisture-curable composition. The composition includes a hydrolysable component and a thermally conductive filler package. The thermally conductive filler package may include thermally conductive, electrically insulative filler particles. The thermally conductive, electrically insulative filler particles may have a thermal conductivity of at least 5 W/m<sup>.</sup>K (measured according to ASTM D7984) and a volume resistivity of at least 1 â¦<sup>.</sup>m (measured according to ASTM D257). At least a portion of the thermally conductive, electrically insulative filler particles may be thermally stable. The present invention also is directed to a method for treating a substrate and to substrates comprising a layer formed from a composition disclosed herein. The present invention also is directed to a coating.
Patent MX-2022013323-A (MX)
Title: Tricyclic compounds as inhibitors of nlrp3.
Inventor: VAN GOOL MICHIEL LUC MARIA
IPC: A61P29/00
Filed: 2021-04-23
Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R<sup>1</sup>, R<sup>2</sup> and R<sup>3</sup> are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.
Patent MX-2023000158-A (MX)
Title: Immune priming to accelerate/enhance immune response through administration of natural immune modulator.
Inventor: DAHL ANDREW A
IPC: A23K50/75
Filed: 2021-06-25
Abstract: A method and compound for altering the status of both innate and adaptive immune pathways in both animals and humans are disclosed. The status alteration results in the immune response being primed whereby an accelerated and more robust response is generated when the animal or human is challenged by pathogens that lead to a wide range of disease states. The disclosed method utilizes a compound derived from a lipopolysaccharide (LPS) of gram-negative bacteria. The compound itself is a natural product with no observed adverse environmental impact. By priming the immune pathways according to the disclosed inventive concept, the severity of various disease states can be reduced, can be resolved more quickly, or can be avoided entirely.
Patent MX-NL06000029-A (MX)
Title: Method for disinfecting treated waste water.
Inventor: PABELLO VICTOR MANUEL LUNA
IPC: C02F1/00
Filed: 2006-04-25
Abstract: Described is a method for disinfecting treated waste water by applying paracetic acid, silver, cooper in variable amounts and for a period of time enough to inactivate the present microorganisms, particularly fecal coliforms and helminthe eggs, which are microorganisms having the highest resistance to any disinfectant type. The method of the present invention is useful for achieving the inactivation of microorganisms (virus, bacteria, protozoa, sea weeds and helminthe eggs) in waters having high and low contents of organic matter and suspended solids; the inventive method has the ability of disinfecting waters having high pathogen contents such as those of developing countries, as well as helminthes eggs. Unlike chloride and ozone, the present invention does not generate toxic byproducts, the inventive method having a residual effect since it uses some silver presentations, thereby controlling the content of microorganisms in sludges originated in stages previous to the process, in case of produced, thus being easily and cost effectively treated and finally deposited amongst other advantages thereof.
Patent MX-PA01006074-A (MX)
Title: Machining tool for highspeed machining.
Inventor: HANS-PETER HOLLFELDER
IPC: B23C5/24
Filed: 2000-09-23
Abstract: The invention relates to a machining tool for carrying out highspeed machining in the machining of metals. According to the invention, at least one cutting body (2) is held by a clamping element (6, 7) in a clamped manner inside a tip seat of a tool holder (1), which is delimited only by one back pressure supporting surface (5) and by one bearing surface. The bearing surface for the clamping element and the bearing surface (4) of the tip seat form an angle (x) that exceeds the selflocking and which is open toward the back pressure supporting surface. The cutting body is provided with a groove (9) in which a sliding pin (10) engages which is arranged, in a manner that is eccentric and parallel to the rotational axis thereof, on a bearing pin (12), which can be actuated from the exterior and which is rotatably mounted in a bearing opening of the tool holder, said bearing opening passing through the bearing surface andor the back pressure supporting surface. The diameter of the sliding pin essentially corresponds to the width (b) of the groove.
Patent MX-PA01006474-A (MX)
Title: Colchinol derivatives as vascular damaging agents.
Inventor: BOYLE FRANCIS THOMAS
IPC: A61K31/167
Filed: 1999-12-24
Abstract: The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R7)- wherein R7 is hydrogen, hydroxy, C1-7alkoxy, -OR8 or -NR8R9 (wherein R8 is a group -Y1R10 (wherein Y1 is a direct bond, -C(O)-, -C(S)-, -S-, -C(O)O, -C(O)NR11-, -SO2- or -SO2NR12- (wherein R11 and R12, which may be the same or different, each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl) and R10 is as defined herein, and R9 includes hydrogen; R1, R2 and R3 are as defined herein and are preferably methyl; R4, R5 and R6 are as defined herein with the proviso that R5 is not hydroxy, alkoxy, substituted alkoxy, -OPO3H2, -O-C1-7alkanoyl or benzyloxy; and salts thereof in the manufacture of a medicament for use in the production of a vascular damaging effect in warm-blooded animals such as humans. The present invention further relates to compounds of the formula (I), pharmaceutical compositions containing them, processes for their preparation and to a method of treatment using the compounds to produce a vascular damaging effect in a warm-blooded animal such as a human. The compounds of formula (I) and the pharmaceutically acceptable salts thereof may be useful in the treatment of a number of disease states including cancer and rheumatoid arthritis.
Patent MX-PA02001486-A (MX)
Title: Artificial tear replacement solution.
Inventor: MENZ DIRK-HENNING
IPC: A61P27/04
Filed: 2000-06-30
Abstract: A tear replacement solution that contains at least one water-soluble fluorosurfactant, water and a non-polar component, preferably in gel form, and a method for the external treatment for the eye of an mammal by applying the tear replacement solution to the eye, preferably by placing in the conjunctival sac.
Patent MX-PA02002684-A (MX)
Title: Mammalian interleukin 12 p40 and interleukin b30, combinations thereof, antibodies, uses in pharmaceutical compositions.
Inventor: RENE DE WAAL MALEFYT
IPC: C12N15/09
Filed: 2000-09-08
Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
Patent MX-PA02005695-A (MX)
Title: Pharmaceutical combinations and their use in treating gastrointestinal disorders.
Inventor: BILLSTEIN STEPHAN ANTHONY
IPC: A61P1/04
Filed: 2000-12-08
Abstract: The present invention relates to a combination of a first agent including either a 5 HT4 receptor agonist or antagonist or a 5 HT3 receptor antagonist and a co agent and pharmaceutical compositions and formulations containing the combination. The pharmaceutical combination may be employed for the treatment of altered gastrointestinal motility, sensitivity, secretion or abdominal disorders. The dosage is preferably oral. The preferred first agent is tegaserod.
Patent MX-PA02008624-A (MX)
Title: A diaper with a pre-fastened adjustable mechanical fastener.
Inventor: HUANG YUNG HSIANG
IPC: A61F13/15
Filed: 2001-03-16
Abstract: A pant-like, prefastened, refastenable, disposable absorbent article includes a pair of fasteners which provide refastenable side seams and at least one waist size adjustment means. The prefastened absorbent article defines a pair of laterally opposed side edges and a pair of longitudinally opposed waist edges. The fasteners are permanently attached to the side edges of one of the waist edges and engage the side edges of the opposed waist edges to form the refastenable side seams defining a waist opening and a pair of leg openings in the prefastened absorbent article. The fasteners are further configured to provide a waist size adjustment means. The waist size adjustment means allows the wearer or the caregiver to reduce or increase the waist perimeter dimension of the prefastened absorbent article to conform the article to the wearer s body after the absorbent article is positioned on the wearer by releasably engaging the waist size adjustment means to the exterior surface of the prefastened absorbent article.
Patent MX-PA02009145-A (MX)
Title: Information display and information providing device.
Inventor: KATO KOSUKE
IPC: H04N21/8543
Filed: 2001-03-12
Abstract: An information display for receiving distributed main display information and distributed information for specifying image information to be displayed, the specified image information being acquired through a path different from that of the main display information. The information display is provided with an information extracting unit and a display control unit. The information extracting unit extracts the main display information and the image specifying information from the information set including the main display information, image specifying information, and image information and acquires image information corresponding to the image specifying information and including related information from an information source through another information path having a transmission mode different from that of the information path through which the main display information is transmitted. The display control unit displays a combination of a first management area where a first image is displayed, a second management area, and the main display information extracted by the information extracting unit.
Patent MX-PA02011335-A (MX)
Title: Method of manufacturing a luminescent screen for a crt.
Inventor: STEVEN ANTHONY COLBERT
IPC: H01J9/22
Filed: 2002-11-15
Abstract: A method of manufacturing a luminescent screen (22) assembly for a color cathode-ray tube (CRT) (10). The luminescent screen assembly is formed on an interior surface of a faceplate panel (12) of the CRT. The luminescent screen assembly includes an organic conductive (OC) layer overcoated with an organic photoconductive (OPC) layer. Different color-emitting phosphors are sequentially deposited over portions of the OPC layer and fixed with an appropriate fixative to secure the phosphors to the OPC layer, and then filmed to provide a smooth surface upon which a metal layer is applied. Thereafter, the metallized screen is baked to drive-off organic constituents remaining on the screen from the OPC, OC, filming and overspray layers. The organic constituents are removed from the metallized screen by volatilizing the organic materials such that the volume rate of gaseous organic constituents produced is less than the diffusion rate of such gaseous organic constituents through the metal laye r.
Patent MX-PA02011786-A (MX)
Title: Beam for drywall ceiling.
Inventor: WILLIAM J PLATT
IPC: E04B9/06
Filed: 2002-11-28
Abstract: A beam for a grid in a ceiling that has drywall affixed to the grid by self-tapping screws. The beam has a hem rolled downwardly and inwardly along the edge of both flanges of the beam. The hem prevents the flange from bending upward and sliding off the screw tip. The screw tip enters one of many indentations in the flange and is captured. The captured screw tip penetrates the flange and secures the drywall to the beam. The beam does not have a face cap over the flanges.
Patent MX-PA03000627-A (MX)
Title: Novel peptides as ns3-serine protease inhibitors of hepatitis c virus.
Inventor: HUANG YUHUA
IPC: A61K38/08
Filed: 2001-07-19
Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
Patent MX-PA03001403-A (MX)
Title: Mineral-enhanced bakery products.
Inventor: MALDONADO ALFONSO
IPC: A23L7/10
Filed: 2000-08-15
Abstract: A wheat flour, and dough made from the flour, are produced using between 5-50 % (desirably 15-45 %, preferably 25-35 %) by weight middlings (e.g. from the first and second breaks) added to straight flour, patent flour, break flour, or clear flour. The flour with middlings can hold more free moisture, and an at least an additional 2-20 % by weight dietary minerals (such as calcium, zinc, iron, manganese, phosphorus, etc.) and/or fibers, and/or other edible materials, can be added without disturbing the fermentation or baking processes. For example, bread having at least 50 % (e. g. 50-200 %) of the RDA of calcium per 32 gm slice may be produced without emulsifiers, calcium citrate, or other equivalent chemical additives.
Patent MX-PA03001953-A (MX)
Title: Method for selecting a font.
Inventor: SAYED TAREK MAHMOUD
IPC: G06F40/00
Filed: 2003-03-05
Abstract: The invention is generally directed to a method for selecting a font that uses a mark-up language document to group together multiple pre-existing fonts into a single font family or "virtual font." The mark-up language document includes rules regarding the conditions under which individual fonts within the family are to be used. This permits, for example, a font developer to create, in an efficient manner, an international font using several preexisting fonts.
Patent MX-PA03006324-A (MX)
Title: Compounds for use in the treatment of skin conditions.
Inventor: RADHAKRISHNAN VENKATASAMY
IPC: A61K47/46
Filed: 2002-01-15
Abstract: The present invention provides compounds of formula (I) and analogues or derivatives thereof for the treatment of skin conditions, such as Vitiligo, which are treatable by the stimulation of melanocyte proliferation and also for treating skin cancer. The compounds may also be used to cosmetically enhance the natural coloration of the skin.
Patent MX-PA03007194-A (MX)
Title: Method for purifying 20(s)-camptothecin.
Inventor: RAINER SOBOTTA
IPC: C07D491/04
Filed: 2002-02-09
Abstract: The invention relates to a method for purifying 20(S) camptothecin by transforming the lactone ring of the 20(S) camptothecin into a carboxylate salt with the help of an aqueous base, hydrogenating the mixture that is obtained in the presence of a transition metal catalyst, acidifying the aqueous phase to form camptothecin crystals, adding a polar aprotic solvent, optionally heating and cooling the mixture and separating the camptothecin crystals.
Patent MX-PA03007874-A (MX)
Title: Stabilised hypobromous acid solutions.
Inventor: MARTHA SOPHIA CILLIERS
IPC: C02F1/50
Filed: 2002-03-01
Abstract: This invention relates to a method for preparing a stabilised stock hypobromous acid solution, and to a stabilised stock hypobromous acid solution. The stabilised stock solution has a hypobromous acid concentration of less than 30% (m/m) and contains an amount of cyanuric acid as a stabiliser not exceeding 1ppm. The solution may be used for treating any type of water, but has particular application in treating drinking water and irrigation water.
Patent MX-PA03008671-A (MX)
Title: Reversible life raft comprising removable shelters.
IPC: B63C9/04
Filed: 2002-03-25
Abstract: A dual-sided, or reversible, inflatable rescue and safety raft consists of an inflated grille provided with mesh netting spanning open regions to accommodate personnel, manually releasable locking devices that close access openings in the netting to permit personnel to board from underneath the floating grille, both surfaces of the grille being provided with fasteners for safety handles and belts; one or more containers with compactly folded modular floor and shelter units that can be fastened to the surface of the grille (or removed from the raft for use as tents on land) are repositionably secured to the grille in the event that the containers are submerged when the raft is initially disposed in the water.
Patent MX-PA03009446-A (MX)
Title: Aromatase inhibition to enhance assisted reproduction.
Inventor: ROBERT F CASPER
IPC: A61K31/56
Filed: 2002-04-17
Abstract: The use of at least one aromatase inhibitor in the production of a medicament for improving the implantation and pregnancy rates for a female undergoing assisted reproduction treatment, which comprises one or more daily doses of an aromatase inhibitor (AI) for administration during assisted reproduction cycles or ovarian stimulation cycles, wherein the doses of AI are selected from amounts effective to reduce serum estradiol levels. Also disclosed are related pharmaceutical preparations and packages.
Patent MX-PA03010315-A (MX)
Title: Method and apparatus for setting an integrity protection uplink application time for signalling bearer rb0 in a universal mobile telecommunications system.
Inventor: NICOLA M FUNNELL
IPC: H04L12/56
Filed: 2003-11-11
Abstract: The details of an apparatus and method are disclosed for setting the Uplink RRC message sequence number for a new integrity protection configuration to be applied for signalling radio bearer RB 0, on completion of a UTRAN MOBILITY INFORMATION procedure. The sequence number is set to a value such that the next RRC message to be sent on uplink RB0 will use the new integrity protection configuration.
Patent MX-PA04002466-A (MX)
Title: Fungicidal composition comprising pyrimethanil and iprodione.
Inventor: DODO HIDEO
IPC: A01P3/00
Filed: 2002-09-17
Abstract: The present invention relates to a novel fungicidal composition comprising pyrimethanil and iprodione in a ratio ranging from 1/3 to 3, and the use of such a composition for controlling particular plant diseases or for controlling specific phytopathogenic fungi present or capable of appearing on plants.
Patent MX-PA04003721-A (MX)
Title: Suspension insulator with a sealing plug.
Inventor: DANIEL DE DECKER
IPC: H01B17/02
Filed: 2004-04-20
Abstract: The suspension insulator comprises an insulating skirt of quenched glass or of porcelain having an underside in which a pin is fixed by a cement-based binder, a sacrificial ring made of zinc in contact with the binder and surrounding the pin, and an annular plug of electrically conductive material disposed between the insulating skirt and the sacrificial ring in such a manner as to provide sealing that prevents leakage currents from passing through the binder. The plug serves to avoid corrosion phenomena of the pin and the risk of the insulator exploding.
Patent MX-PA04004440-A (MX)
Title: A method for treating inflammatory bowel disease.
Inventor: LAUREN CHAROUS
IPC: A61K9/22
Filed: 2002-11-12
Abstract: The present invention is directed to a method for treating inflammatory bowel disease in a patient comprising administering to said patient a pharmaceutical compositions comprising a pharmaceutically effective amount of an anti-malarial compound in association with a pharmaceutically acceptable carrier and/or excipient that delays and targets the release of the anti-malarial compound in the gastrointestinal tract of the patient. It is also directed to the pharmaceutical composition comprising a pharmaceutically effective amount of the anti-malarial compound in association with a pharmaceutically acceptable carrier or excipient that delays and target the release of the anti-malarial compound in the gastrointestinal tract.
Patent MX-PA04007526-A (MX)
Title: Method and apparatus for evaporating multi-component liquids.
Inventor: JESSE BEN CRANDALL
IPC: B05B17/06
Filed: 2003-02-04
Abstract: An atomizer 10 atomizes a multi-component liquid from a reservoir 20 into a cloud 14 comprising small droplets 38 which are ejected into the atmosphere to a certain height and allowed to fall toward a surface 12. Essentially complete evaporation is assured by maintaining the size of the droplets, the liquid's component vapor pressures and the height through which the droplets fall according to a predetermined relationship. Also, the suitability of a liquid for evaporation in a vibrating plate atomizer is determined by measuring the rate of size decrease and the surface tension of a pendant drop of the liquid after a predetermined amount of the liquid has evaporated from the drop.