Patent SG-11201907848Y-A (SG)
Title: Antibodies binding to vista at acidic ph
Inventor: JOHNSTON ROBERT J
IPC: A61K39/395
Filed: 2018-03-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo ominionni mom oimIE (10) International Publication Number WO 2018/169993 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/30 (2006.01) CO7K 16/28 (2006.01) (21) International Application Number: PCT/US2018/022230 (22) International Filing Date: 13 March 2018 (13.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,196 14 March 2017 (14.03.2017) US 62/636,746 28 February 2018 (28.02.2018) US (71) Applicants: FIVE PRIME THERAPEUTICS, INC. [US/US]; 111 Oyster Point Blvd., South San Francisco, Cal- ifornia 94080 (US). BRISTOL-MYERS SQUIBB COM- PANY [US/US]; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). (72) Inventors: JOHNSTON, Robert J.; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). RAJPAL, Arvind; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). SHEP- PARD, Paul O.; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). BORGES, Luis; 111 Oyster Point Blvd., South San Francisco, California 94080 (US). RANKIN, Andrew; 111 Oyster Point Blvd., South San Francisco, California 94080 (US). BAHJAT, Keith; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). KORMAN, Alan; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). DENG, Andy X.; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). SU, Linhui Julie; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). RAKESTRAW, Ginger; Rte. 206 & Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 (US). (74) Agent: DOHERTY, Elizabeth et al.; McNeill Baur PLLC, 125 Cambridge Park Drive, Suite 301, Cambridge, Massa- chusetts 02140 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (54) Title: ANTIBODIES BINDING TO VISTA AT ACIDIC PH v7 TA .9.00 Etpleigth 01 01 01 FIG. 1A (57) : The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppres- sor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically © to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH. C [Continued on next page] WO 2018/169993 Al MIDEDIMOMOIDEIREEMOMOHIMEHOHMOIMEN CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))