Patent SG-11201909016T-A (SG)
Title: Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
Inventor: BEVILACQUA MICHAEL P
IPC: A61K38/00
Filed: 2018-04-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit °nolo moimm mum° oimIE (10) International Publication Number WO 2018/187617 Al (51) International Patent Classification: A61K 38/00 (2006.01) A61K 9/08 (2006.01) A61K 38/16 (2006.01) A61P 31/04 (2006.01) (21) International Application Number: PCT/US2018/026322 (22) International Filing Date: 05 April 2018 (05.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,630 06 April 2017 (06.04.2017) US (71) Applicant: AMICROBE, INC. [US/US]; 3142 Tiger Run Court, Suite 101, Carlsbad, California 92010 (US). (72) Inventors: BEVILACQUA, Michael P.; 3142 Tiger Run Court, Suite 101, Carlsbad, California 92010 (US). HUANG, Daniel J.; 3142 Tiger Run Court, Suite 101, Carlsbad, California 92010 (US). LOOKER, Doug; 3142 Tiger Run Court, Suite 101, Carlsbad, California 92010 (US). (74) Agent: MALLON, Joseph J.; Knobbe, Martens, Olson & Bear LLP, 2040 Main Street 14th Floor, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: COMPOSITIONS AND USES OF LOCALLY APPLIED ANTIMICROBIALS WITH ENHANCED PERFORMANCE AND SAFETY 5/5 5/5 0/5 0/5 Wata K-100 KL-140/2 .5-RAN Kit-12015.0 FIG. 32 1-1 N 1-1 N 00 1-1 00 1-1 O C (57) : The present invention relates to an antimicrobial pharmaceutical composition, comprising an aqueous carrier; and an antimicrobial synthetic cationic polypeptide(s) dispersed in the aqueous carrier at a concentration in the range of about 0.01% to about 5%, by weight based on total weight of the antimicrobial pharmaceutical composition, wherein the antimicrobial synthetic cationic polypeptide(s) comprises a plurality of positively charged amino acid units at neutral pH, and fulfils certain viscosity and toxicity requirements. The invention further relates to a method of preventing microbial contamination of tissues other than intact, healthy skin, comprising administering the present antimicrobial pharmaceutical composition in an amount effective to at least partially protect the tissue site from becoming contaminated with microbes. [Continued on next page] WO 2018/187617 Al MIDEDIM01101 DIDIMMIN0MMEIHR1111111111111111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))