Patent SG-11201406943X-A (SG)
Title: Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
Inventor: LOWMAN HENRY BERNARD
IPC: A61K39/00
Filed: 2013-04-26
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 31 October 2013 (31.10.2013) WIPOIPCT (10) International Publication Number WO 2013/163631 A3 (51) International Patent Classification: A61K 39/00 (2006.01) C12P 21/08 (2006.01) C07K16/28 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/639,796 61/662,204 61/749,220 61/749,529 61/763,237 PCT/US2013/038540 26 April 2013 (26.04.2013) English English US US us us us 27 April 2012 (27.04.2012) 20 June 2012 (20.06.2012) 4 January 2013 (04.01.2013) 7 January 2013 (07.01.2013) 11 February 2013 (11.02.2013) (71) Applicant: CYTOMX THERAPEUTICS, INC. [US/US]; 650 Gateway Boulevard #125, South San Fran­ cisco, CA 94080-7014 (US). (72) Inventors: LOWMAN, Henry Bernard; P.O. Box 2556, El Granada, CA 94018-2256 (US). DESNOYERS, Luc Roland; 250 Claremont Boulevard, San Francisco, CA 94127 (US). LIU, Shouchun; 1795 Hunt Drive, Burl- ingame, CA 94010 (US). WEST, James William; 724 Laurel Avenue, Apt. #404, San Mateo, CA 94401 (US). SAGERT, Jason Gary; 231 Laurie Meadows Road, Apt. #153, San Mateo, CA 94403 (US). VASILJEVA, Olga; 20080 Rodrigues Avenue #D, Cupertino, CA 95104 (US). MENENDEZ, Elizabeth-Edna Mary; 2235 Southampton Way, San Mateo, CA 94403 (US). (74) Agents: ELRIFI, Ivor R. et al.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.C., One Financial Center, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) [Continued on next page] (54) Title: ACTIVATABLE ANTIBODIES THAT BIND EPIDERMAL GROWTH FACTOR RECEPTOR AND METHODS OF USE THEREOF T-H m m T-H rn r M { > rifcii Sites of disease Protease- triggered activation / : jProbody: >#<4 *4<4 Antibody Normal tissue Site of toxicity lit* FIGURE 1A © (57) Abstract: The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety ^ (CM), antibody and an (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and us - Q ing these anti- EGFR activatable antibodies in variety of therapeutic, diagnostic and a prophylactic indications. WO 2013/163631 A3 III lillll IIII III Hill 11 III III III fill I II 111 llll 111 111 mill llll 111 llll - before the expiration of the time limit for amending the (88 » Date of publication of the international search report: claims and to be republished in the event of receipt of * amendments (Rule 48.2(h))