baber/WOPTO huggingface dataset:
Patent JP-2694156-B2 (JP)
Inventor: RICE KENNER CRALLE
IPC: C07D489/02
Filed: 1990-10-16
Granted: 1997-12-24
Abstract: Families of antagonist-agonists and opiate narcotics are produced from norhydrocodeinone. In a preferred embodiment, norhydrocodeinone is refluxed with sulfosalicyclic dimethylketal and delta-6-enol ether derivatives and is then converted entirely to the ether by the addition of dry tetrahydrofuran simultaneously with the removal of the thus produced ether. The ether is then reacted with methanesulfonic acid and N-bromoacetamide to form the hydrobromide salt of the 7-bromodimethylketal derivative. From this derivative, a variety of products can be derived, including the novel further intermediate 14 hydroxynorcodeinone. The present invention enables derivation using a starting material which, unlike the starting materials of prior art processes, is available in the natural (-) or synthetic (+) form. Thus, the method of the present invention provides the only known route for the synthesis of (+) forms of various derivatives and intermediates, such as (+)-7-bromo-dimethylketal nordihydrocodeinone.
Patent JP-H084019-B2 (JP)
IPC: H01R12/55
Filed: 1986-01-30
Abstract: A solderable lead is provided for connecting an electrically conductive element (such as a terminal clip, or a connector contact, or a semiconductor chip holder terminal) to a metallic area on a substrate or the like, the solderable lead having a discrete slug of solder mechanically engaged in a special way in a position to be melted for bonding the lead to the metallic area. In one form of solderable lead, a terminal clip portion adapted to be secured to a metallic area on a second substrate is also provided, the terminal clip portion having one or two additional discrete masses of solder mechanically engaged with the clip portion in position to be melted for bonding the clip to one or two metallic areas on the second substrate.
Patent JP-3194928-B2 (JP)
IPC: C12N15/09
Filed: 1989-01-27
Granted: 2001-08-06
Abstract: Prodn. of polypeptides is effected by expression of genes in the form of DNA mols. in a cell-free transcription/translation system contg. amino acids, ATP, GTP, CTP and UTP as substrates, resulting in the formation of prods. including polypeptides, AMP, ADP, GDP, CDP, UDP, pyrophosphates and inorganic phosphates. The process is operated continuously, where the prods. are withdrawn as they are formed and the substrates are added so as to maintain their initial concns.
Patent JP-3200604-B2 (JP)
IPC: A61P31/04
Filed: 1991-12-20
Granted: 2001-08-20
Abstract: The invention relates to the use of a compound according to formula (I) <CHEM>  in which X is an integer of from 2 to 5 and     A signifies - NH - C(=NH) - NH2 or - CH2 - NH2 for the preparation of a medicament for treatment of endotoxin-induced effects, particularly for suppressing endotoxin-induced pyrexia. The medicament is preferably administered orally, intravenously, intramuscularly, intracutaneously or intraperitoneally in an amount of 10-800 mg/kg body weight and hour.
Patent JP-3577322-B2 (JP)
IPC: B30B9/28
Filed: 1998-06-18
Granted: 2004-10-13
Abstract: The process consists of compacting each type of waste (2), forming briquettes (9) with a spherical, cylindrical, prismatic shape, etc. formed in the compacting chamber (3) of the machine. A binding material, such as a resin, and a dye, which color indicates the type of waste, are injected in the briquette in a final stage. After polymerization and solidification, the briquettes are diverted automatically to a storage chamber (24) for their subsequent transfer. The machine includes a compacting chamber (3) with a side wall (5) and a top wall (8) movable by means of respective hydraulic cylinders (6,7). The bottom has a movable plate (12) with holes (13) for evacuating liquids. <IMAGE>
Patent JP-3273170-B2 (JP)
IPC: E01B19/00
Filed: 1993-07-20
Granted: 2002-04-08
Abstract: PCT No. PCT/FR93/00706 Sec. 371 Date Jan. 20, 1995 Sec. 102(e) Date Jan. 20, 1995 PCT Filed Jul. 20, 1993 PCT Pub. No. WO94/02685 PCT Pub. Date Feb. 3, 1994Rail support device for unballasted railway track comprising at least one concrete block resting on a flexible base, the assembly being held in an elastomeric shell which is anchored in a bed or mortar covering the lower part of said block, and which has a beading around its top edge. The horizontal cross section of said block is variable and has a maximum area at the level immediately below the beading on the upper edge of the shell so as to limit the relative movement of the block and the shell by means of an elastic force.
Patent JP-H075588-B2 (JP)
IPC: A61K31/4402
Filed: 1985-10-29
Abstract: Picoline derivatives of the formula I   <IMAGE> (I)  wherein the substituents have the meanings given in the description, and their salts are new compounds having a pronounced protective action on the stomach.
Patent JP-H0699423-B2 (JP)
IPC: A61K31/47
Filed: 1991-03-04
Abstract: PCT No. PCT/US91/01470 Sec. 371 Date Nov. 6, 1992 Sec. 102(e) Date Nov. 6, 1992 PCT Filed Mar. 4, 1991 PCT Pub. No. WO91/17156 PCT Pub. Date Nov. 14, 1991.5-(1-Hydroxy-2-piperidinopropyl)-2(1H,3H)-indolone derivatives and analogs; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.
Patent JP-2582012-B2 (JP)
IPC: B64D13/06
Filed: 1991-02-13
Granted: 1997-02-19
Abstract: PCT No. PCT/SE91/00098 Sec. 371 Date Aug. 31, 1992 Sec. 102(e) Date Aug. 31, 1992 PCT Filed Feb. 13, 1991 PCT Pub. No. WO91/13803 PCT Pub. Date Sep. 19, 1991.In order to prevent moisture from condensing into water in an intermediate space between an outer hermetic shell and an inner partition of an airplane, or for removing any water present in the intermediate space, dry air having a relative humidity of less than 50% is directed into the intermediate space from a dehumidifying device which accepts humid air from inside the passenger compartment.
Patent JP-2641281-B2 (JP)
IPC: C08L61/12
Filed: 1988-07-29
Granted: 1997-08-13
Abstract: Disclosed is the reaction product of: a solvent-carried component chosen from the group consisting of resorcinol and a mixture of resorcinol and phenol and a solvent-carried first aldehyde component to provide a novolac resin. This novolac resin thereby being pre-mixed, to provide a novolac resin in solvent with a solids content of about 64 % to 83 % and a viscosity of about 250 to 3500 cps. A second aldehyde component is added at the time of use to bring the aldehyde percentage to 100 % or more of the equivalent amount of total aldehyde to phenolic hydroxyl radicals and to retain a high solids content with a workable viscosity. This mixture is then spread upon a fire resistive reinforcing fiberglass material, and the solvent is removed at the time of cure to provide a fire-resistant reinforced plastic material.
Patent JP-2746399-B2 (JP)
IPC: F16G11/00
Filed: 1988-11-11
Granted: 1998-05-06
Abstract: PCT No. PCT/AT88/00094 Sec. 371 Date May 10, 1990 Sec. 102(e) Date May 10, 1990 PCT Filed Nov. 11, 1988 PCT Pub. No. WO89/04281 PCT Pub. Date May 18, 1989.A releasable fastening element for tying, bundling and fastening articles having at least one head element, including a longitudinally extending shaft with a leg extending from one end thereof to form a hook for engaging the material to be bound. The fastening element includes an elastic strap which is connected to the other end of the shaft. The elastic strap has locking elements placed at predetermined points along its length for individually and removably connecting the strap to a locking member. The locking member, which is located on the shaft, is formed by two oppositely aligned insertion grooves which are arranged parallel and adjacent to the shaft. The locking elements, which are wider than the grooves, are restricted from passing through the locking device, thus forming a loop in the strap for engaging the material to be bound. The locking member can also be formed as a sleeve with open ends mounted on the shaft parallel to the longitudinal direction thereof. The locking member can also be formed by two oppositely aligned insertion grooves cut into the shaft.
Patent JP-3983798-B2 (JP)
IPC: C12N15/63
Filed: 1993-12-22
Granted: 2007-09-26
Abstract: A method of amplifying in vivo a DNA sequence B present in a genome of a parent cell, comprising (a) integrating in a genome of said cell a DNA construct comprising the structure C-M-A-D, in which both A and C denote a DNA sequence which is homologous with a genomic DNA fragment either flanking or overlapping the DNA sequence B to be amplified or being a subsequence of the DNA sequence B constituting one of the ends of said sequence B, the sequence C being located in the opposite end of the sequence B as compared to A, D denotes a DNA sequence which is homologous with a genomic DNA fragment located distal for C as compared to B, and M denotes a DNA sequence encoding a selection marker, (b) selecting for cells in wich the DNA sequence M has been integrated in the genome, which cells comprise, in any orientation, the structure A-B-C-M-A-D, and (c) propagating the cells selected in step (b) under increasing selection pressure to obtain a cell which has obtained an increased number of genomically integrated copies of the DNA sequences B and M.
Patent JP-2909772-B2 (JP)
IPC: C08F210/16
Filed: 1990-11-08
Granted: 1999-06-23
Abstract: PCT No. PCT/FR90/00801 Sec. 371 Date Jul. 29, 1991 Sec. 102(e) Date Jul. 29, 1991 PCT Filed Nov. 8, 1990 PCT Pub. No. WO91/07447 PCT Pub. Date May 30, 1991.Polyolefin rubber which is an ethylene/propylene and/or 1-butene copolymer, which has a melt index of 0.3 to 15 dg/min and a relative density of 0.860 to 0.885, comprising 74-91 mol % of units derived from ethylene and 9-26 mol % of units derived from propylene and/or from 1-butene, characterised by a crystalline melting point J of 100 DEG  to 125 DEG  C. The process for obtaining this rubber consists in copolymerising, at a temperature of 150 DEG -300 DEG  C. and at a pressure of 400-2000 bars, a gas stream containing 15-42% by vol. of ethylene and 58-85% by vol. of propylene and/or 1-butene, in the presence of a Ziegler-type catalyst system comprising at least one compound of a transition metal of groups IVB, VB, VIB and VIII of the Periodic Classification, and at least one organoaluminium compound and, if appropriate, in the presence of at least one chain transfer agent. Manufacture of articles such as seals, shoe components, flexible tubing, damping components, profiles for buildings and motor vehicles, and the like.
Patent JP-4194655-B2 (JP)
IPC: C01B35/12
Filed: 1996-10-16
Granted: 2008-12-10
Abstract: An improved method is provided for producing crystalline calcium hexaborate tetrahydrate, synthetic nobleite, by the reaction of boric acid and lime in an aqueous slurry. Reaction conditions include boric acid to water molar ratios of greater than 0.25:1, lime to boric acid molar ratios in the range of 0.05-0.15:1 and temperatures in the range of 85 DEG -105 DEG  C. A novel crystalline product is produced having a unique crystal habit resulting in improved physical properties. Dehydration of this product produced a novel amorphous, anhydrous product having similar crystal habit and physical properties.
Patent JP-3871710-B2 (JP)
IPC: A61K38/00
Filed: 1995-11-14
Granted: 2007-01-24
Abstract: PCT No. PCT/SE95/01350 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Nov. 14, 1995 PCT Pub. No. WO96/15140 PCT Pub. Date May 23, 1996The present invention relates to a process for purifying recombinant coagulation factor VIII by loading an aqueous solution containing factor VIII onto a hydrophobic interaction chromatography (HIC) gel, wherein at least one surfactant is present in the aqueous solution and/or a buffer solution used to equilibrate the gel prior to loading the aqueous solution onto the gel. The presence of a surfactant when loading the solution containing factor VIII onto the HIC gel, makes it possible to efficiently separate the intact and active factor VIII molecules from molecules with structural deviations. With the present invention it is further possible to reduce the content of DNA and/or CHO cell contaminants considerably and increase the activity of the factor VIII product to a hitherto unknown extent. The invention further relates to an aqueous solution containing recombinant factor VIII which has been purified according to the present process and use of such an aqueous solution, for the manufacture of a medicament for administration to a patient having the symptoms of hemophilia. Also, the invention relates to a method for treatment of hemophilia by administration of a therapeutically effective amount of recombinant factor VIII which has been purified according to the present process.
Patent JP-3708958-B2 (JP)
IPC: A61K47/48
Filed: 1993-03-18
Granted: 2005-10-19
Abstract: Method for reducing side-effects of a drug caused by undesired effects of said drug upon body cells which are not the intended target of said drug comprising the preferential delivery of antidote for said drug to said body cells when said drug is used, said preferential delivery effected by attaching to said antidote antibody with affinity for said body cells.
Patent JP-3844358-B2 (JP)
IPC: C12Q1/6816
Filed: 1995-04-06
Granted: 2006-11-08
Abstract: Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved sensitivity are disclosed. In addition, the synthesis of these esters and their use in assays for detecting an analyte is described. In particular, assays for testosterone and the Rubella virus are disclosed.
Patent JP-4281851-B2 (JP)
IPC: A61F2/915
Filed: 1997-03-05
Granted: 2009-06-17
Abstract: An expandable stent (10) having a proximal end (15) and a distal end (20) in communication with one another. A tubular wall (25) is disposed between the proximal end and the distal end, and has a longitudinal axis. The tubular wall has a porous surface defined by a plurality of intersecting members (30) arranged to define a first repealing pattern comprised of a polygon having a pair of sidewalls (35,40) and substantially parallel to the longitudinal axis, a concave-shaped (50) first wall having a first apex (54), and a convex-shaped (60) second wall having a second apex (64). The first wall and the second wall connect the sidewalls, and at least one of the first apex and the second apex is substantially flat. The first apex and the second apex are of different lengths. The stent is expandable from a first, contracted position to a second, expanded position upon the application of a radially outward force on the stent.
Patent JP-4495258-B2 (JP)
IPC: A23L33/00
Filed: 1998-04-14
Granted: 2010-06-30
Abstract: The use of a membrane of polymethyl methacrylate (PMMA; including copolymers) is claimed for binding materials coupled with polyethylene glycol (PEG). Also claimed is an extracorporeal therapeutic system, including a membrane of PMMA on which a PEG-coupled physiologically active agent (A) is bound.
Patent ES-2344187-B2 (ES)
Title: Galleta funcional a partir de harina de teff para celiacos y procedimiento para su preparacion.
Inventor: CALLEJO GONZALEZ MARIA JESUS
IPC: A21D13/047
Filed: 2010-06-16
Granted: 2012-06-01
Abstract: Galleta funcional para celíacos a partir de harina de teff que está exenta de hidrocoloides, almidones y grasas añadidas, cuya formulación comprende los siguientes ingredientes, según unas proporciones en peso basadas en la cantidad inicial de harina de teff: leche desnatada, 92-96%; yogurt natural desnatado, 26-30%; azúcar moreno, 12-16%; cacao en polvo desgrasado, 2-5%; ralladura de naranja, 6-10%, y avellanas trituradas, 15-20%, y un procedimiento para preparar dicha galleta funcional que comprende las siguientes etapas: mezcla de ingredientes y amasado, reposo, laminado, troquelado y horneado.
Patent ES-2662958-B2 (ES)
Title: Máquina para la producción de contenedores a modo de caja
Inventor: TROVENZI GIUSEPPE
IPC: B31B50/00
Filed: 2017-10-05
Granted: 2018-08-09
Abstract: Máquina para la producción de contenedores a modo de caja.#La máquina comprende al menos una unidad de producción (A, B) en la que se lleva a cabo la retirada automatizada de unas placas de base (82) y de unas tiras o bandas (83) de los grupos de carga (2, 4) y su disposición sobre unas matrices (9) dispuestas sobre una mesa (6) giratoria para posicionar cada vez una de las matrices (9) en correspondencia con una estación de grapado (12) en la que los medios de grapado (17) realizan el grapado de una tira o banda (83) en una placa de base (82) para obtener un fondo (81a) o una tapa (81b) de un contenedor a modo de caja (80).
Patent IE-S86124-B2 (IE)
Title: Permanent formwork system for reinforcing concrete structures
Inventor: HURLEY GERALD
IPC: E04C5/00
Filed: 2012-09-21
Abstract: A wall connector (100) for locating between two parallel sheets of fibre cement formwork boards (100,102) maintains the sheets in a parallel arrangement with other like wall connectors. Each wall connector comprises an oblong shaped body having two pairs of mutually opposed side walls (104,106,108,110)and a pair of open ends. The first pair of mutually opposed side walls (104, 106) is spaced apart from one another by a first distance "Y" and the second pair of mutually opposed side walls (108,110) is spaced apart from one another by a second distance "Z" which is greater than or less than the first distance "Y" but not equal to the first distance. Each of the respective pairs of side walls is securable to the sheets so as to maintain the sheets apart by either the first or second distance "Y" or "Z". The ends of the oblong body are substantially open to allow for the flow of concrete, cement or other setting material. <Figure 1>
Patent IE-S87062-B2 (IE)
Title: Two sulfide double sulfur carbonyl two methylamine [thiram] drugs intermediates synthesis method
Inventor: RUER LIAO
IPC: C07C333/00
Filed: 2018-08-16
Abstract: The present invention discloses two sulfide double sulfur carbonyl two methylamine drugs intermediates synthesis method, comprises the following steps: two methylamine solution and sodium nitrate solution were added to the reaction vessel, controlled the reaction temperature of the solution, controlled the mixing speed, added 1-pentanthiol solution, added the tetrahydrothiophene solution in batches, continued to react; then added nickel bromide powder, controlled the reaction temperature of the solution, added four lead acetate, continued to react, let stand, added potassium chloride solution, layered, separated out the reservoir, washed with 2-heptanone solution, recrystallized in 1-chloropropane solution, dehydrated with dehydration, got the finished product two sulfide double sulfur carbonyl two methylamine. <Figure 1>
Patent AU-2002253570-B2 (AU)
Title: Anti-staining coating solution comprising inorganic polysilazane
Inventor: SUZUKI TADASHI
IPC: C09D183/16
Filed: 2002-04-24
Granted: 2008-04-10
Abstract: By applying the solution comprising 0.5 to 10 % by weight of an inorganic polysilazane having repeating units represented by the general formula below and soluble in a solvent and a catalyst such as 4,4'-trimethylenebis (1-methylpiperidine) etc. onto the surfaces of the bodies and wheels of automobiles, dentures, tombstones, the interior and exterior of a house, products used with water in toilets, kitchens, washrooms, bathtubs, etc., signboards, signs, plastic products, glass products, etc., a rigid and dense silica coating is formed to confer a long-durable hydrophilic effect and anti-fouling effect on the surfaces. The solvent is properly selected from mineral spirit, paraffin type solvents, aromatic solvents, alicyclic solvents and mixture thereof depending on the article being coated.
Patent AU-2003213233-B2 (AU)
Title: Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic escherichia coli infections
Inventor: CASSELS FREDERICK J
IPC: C12N1/21
Filed: 2003-02-24
Granted: 2009-02-05
Abstract: Disclosed herein are methods for making large amounts of highly pure colonization factors. The methods of the present invention differ from prior art methods in that host cells which express the colonization factor of interest are cultured in media comprising more than about 50 mug/l of an antibiotic, the media is centrifuged and then filtered with a 0.2 mum filter tangential flow cartridge and a 300,000 MW cut-off filter, and a divalent cation is added. As disclosed herein the colonization factors made by the method of the present invention may be used in pharmaceutical compositions and methods for treating or preventing enterotoxigenic Escherichia coli infections.
Patent AU-2003281046-B2 (AU)
Title: Process for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
Inventor: SHIN SANG-HOON
IPC: C01G25/00
Filed: 2003-07-15
Granted: 2009-02-19
Abstract: Disclosed is a process for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine (called Famciclovir), a drug of purine derivatives having antiviral activity. This process comprises reacting 2-aminopurine with 2-acetoxymethyl-4-bromobut-1-yl-acetate in the presence of thallium (1) ethoxide to give the desired compound. According to this process, the desired compound can be prepared in very high selectivity and purity under mild reaction conditions.
Patent AU-2004219443-B2 (AU)
Title: Holographic sensors and their production
Inventor: DAVIDSON COLIN ALEXANDER BENNE
IPC: G01N21/31
Filed: 2004-03-11
Granted: 2007-04-26
Abstract: A sensor comprising a medium and, disposed throughout the volume thereof, a holographic element whose fringes are defined by different degrees of swellability in a liquid.
Patent AU-2004225527-B2 (AU)
Title: Proteomic analysis of biological fluids
Inventor: NAGALLA SRI
IPC: G01N33/68
Filed: 2004-03-23
Granted: 2009-10-29
Abstract: The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid. And in particular, the invention concens the correlation of expression levels of haptoglobin with intra-amniotic infection.
Patent AU-2004230413-B2 (AU)
Title: Photocurable adhesive composition and its use in the optical field
Inventor: TURSHANI YASSIN
IPC: C09J4/00
Filed: 2004-04-15
Granted: 2010-03-11
Abstract: The invention concerns a photocurable adhesive composition comprising, based on total weight of photopolymerizable monomers and/or oligomers of the composition: 5 to 60 wt % of at least one mono or polyacrylate monomer or oligomer thereof (A); 5 to 50 wt % of at least one thio(meth)acrylate monomer or oligomer thereof (B); and 20 to 50 wt % of at least one aromatic dimethacrylate monomer or oligomer thereof (C); with the proviso that the composition does not contain a brominated monofunctional acrylate.
Patent AU-2004232544-B2 (AU)
Title: New polymorphs of olanzapine hydrochloride
Inventor: SZENT-KIRALLYI ZSUZSA
IPC: A61P25/18
Filed: 2004-04-22
Granted: 2010-06-03
Abstract: The present invention relates to new crystalline forms I, II and III of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine hydrochloride, a process for the preparation thereof and pharmaceutical compositions containing the same. Said new polymorphic forms are useful as active ingredients for the treatment of psychotic conditions.