Patent ES-2530492-T3 (ES)
Title: Compuestos farmacéuticamente activos como inhibidores AXL
Inventor: SCHULTZ-FADEMRECHT CARSTEN
IPC: C07D417/14
Filed: 2011-08-26
Granted: 2015-03-03
Abstract: Los compuestos que tienen la fórmula general (I)**fórmula** donde A representa C-R10, N; B representa C-R11, N; D representa uno de los siguientes heterociclos**Fórmula** R1, R4, R88, R92, R100 se seleccionan de forma mutuamente independiente a partir de -H, -F, -Cl, -Br, -I, -OH, -NH2, - NHR19, -NR19R20, -OCH3, -OC2H5, -OC3H7, -OCH(CH3)2, -OC(CH3)3, -OC4H9, -NO2, -CHO, -COCH3, - COC2H5, -Ociclo-C3H5, -OCH2-ciclo-C3H5, -O-C2H4-ciclo-C3H5, -OPh, -COC3H7, -COCH(CH3)2, -COC(CH3)3, - COOH, -COOCH3, -COOC2H5, -COOC3H7, -COOCH(CH3)2, -COOC(CH3)3, -OOC-CH3, -OOC-C2H5, -OOCC3H7, -OOC-CH(CH3)2, -OOC-C(CH3)3, -NHCH3, -NHC2H5, -NHC3H7, -NHCH(CH3)2, -NHC(CH3)3, -N(CH3)2, - N(C2H5)2, -N(C3H7)2, -N[CH(CH3)2]2, -N[C(CH3)3]2, -OCF3, -OC2F5, -CH2F, -CHF2, -CF3, -CH2Cl, -CH2Br, - CH2I, -CH2-CH2F, -CH2-CHF2, -CH2-CF3, -CH2-CH2Cl, -CH2-CH2Br, -CH2-CH2I, ciclo-C3H5, -CH2-ciclo-C3H5, - CH3, -C2H5, -C3H7, -CH(CH3)2, -C4H9, -CH2-CH(CH3)2, -CH(CH3)-C2H5, -C(CH3)3, -C5H11, -CH(CH3)-C3H7, - CH2-CH(CH3)-C2H5, -CH(CH3)-CH(CH3)2, -C(CH3)2-C2H5, -CH2-C(CH3)3, -CH(C2H5)2, -C2H4-CH(CH3)2, - C6H13, -C3H6-CH(CH3)2, -C2H4-CH(CH3)-C2H5, -CH(CH3)-C4H9, -CH2-CH(CH3)-C3H7, -CH(CH3)-CH2- CH(CH3)2, -CH(CH3)-CH(CH3)-C2H5, -CH2-CH(CH3)-CH(CH3)2, -CH2-C(CH3)2-C2H5, -C(CH3)2-C3H7, - C(CH3)2-CH(CH3)2, -C2H4-C(CH3)3, -CH(CH3)-C(CH3)3, -CH>=CH2, -CH2-CH>=CH2, -C(CH3)>=CH2, -CH>=CH-CH3, -C2H4-CH>=CH2, -CH2-CH>=CH-CH3, -CH>=CH-C2H5, -CH2-C(CH3)>=CH2, -CH(CH3)-CH>=CH, -CH>=C(CH3)2, - C(CH3)>=CH-CH3, -CH>=CH-CH>=CH2, -C3H6-CH>=CH2, -C2H4-CH>=CH-CH3, -CH2-CH>=CH-C2H5, -CH>=CH-C3H7, - CH2-CH>=CH-CH>=CH2, -CH>=CH-CH>=CH-CH3, -CH>=CH-CH2-CH>=CH2, -C(CH3)>=CH-CH>=CH2, -CH>=C(CH3)- CH>=CH2, -CH>=CH-C(CH3)>=CH2, -C2H4-C(CH3)>=CH2, -CH2-CH(CH3)-CH>=CH2, -CH(CH3)-CH2-CH>=CH2, -CH2- CH>=C(CH3)2, -CH2-C(CH3)>=CH-CH3, -CH(CH3)-CH>=CH-CH3, -CH>=CH-CH(CH3)2, -CH>=C(CH3)-C2H5, - C(CH3)>=CH-C2H5, -C(CH3)>=C(CH3)2, -C(CH3)2-CH>=CH2, -CH(CH3)-C(CH3)>=CH2, -C(CH3)>=CH-CH>=CH2, - CH>=C(CH3)-CH>=CH2,- CH>=CHC(CH3)>=CH2, -C4H8-CH>=CH2, -C3H6-CH>=CH-CH3, -C2H4-CH>=CH-C2H5, -CH2- CH>=CH-C3H7, -CH>=CH-C4H9, -C3H6-C(CH3)>=CH2, -C2H4-CH(CH3)-CH>=CH2, -CH2-CH(CH3)-CH2-CH>=CH2, - CH(CH3)-C2H4-CH>=CH2, -C2H4-CH>=C(CH3)2, -C2H4-C(CH3)>=CH-CH3, -CH2-CH(CH3)-CH>=CH-CH3, -CH(CH3)- CH2-CH>=CH-CH3, -CH2-CH>=CH-CH(CH3)2, -CH2-CH>=C(CH3)-C2H5, -CH2-C(CH3)>=CH-C2H5, -CH(CH3)- CH>=CH-C2H5, -CH>=CH-CH2-CH(CH3)2, -CH>=CH-CH(CH3)-C2H5, -CH>=C(CH3)-C3H7, -C(CH3)>=CH-C3H7, -CH2- CH(CH3)-C(CH3)>=CH2, -CH(CH3)-CH2-C(CH3)>=CH2, -CH(CH3)-CH(CH3)-CH>=CH2, -CH2-C(CH3)2-CH>=CH2, - C(CH3)2-CH2-CH>=CH2, -CH2-C(CH3)>=C(CH3)2, -CH(CH3)-CH>=C(CH3)2, -C(CH3)2-CH>=CH-CH3, -CH(CH3)- C(CH3)>=CH-CH3, -CH>=C(CH3)-CH(CH3)2, -C(CH3)>=CH-CH(CH3)2, -C(CH3)>=C(CH3)-C2H5, -CH>=CH-C(CH3)3, - C(CH3)2-C(CH3)>=CH2, -CH(C2H5)-C(CH3)>=CH2, -C(CH3)(C2H5)-CH>=CH2, -CH(CH3)-C(C2H5)>=CH2, -CH2- C(C3H7)>=CH2, -CH2-C(C2H5)>=CH-CH3, -CH(C2H5)-CH>=CH-CH3, -C(C4H9)>=CH2, -C(C3H7)>=CH-CH3, - C(C2H5)>=CH-C2H5, -C(C2H5)>=C(CH3)2, -C[C(CH3)3]>=CH2, -C[CH(CH3)(C2H5)]>=CH2, -C[CH2-CH(CH3)2]>=CH2, - C2H4-CH>=CH-CH>=CH2, -CH2-CH>=CHCH2- CH>=CH2, -CH>=CH-C2H4-CH>=CH2, -CH2-CH>=CH-CH>=CH-CH3, - CH>=CH-CH2-CH>=CH-CH3, -CH>=CH CH>=CH-C2H5, -CH2-CH>=CH-C(CH3)>=CH2, -CH2-CH>=C(CH3)-CH>=CH2, - CH2-C(CH3)>=CH-CH>=CH2, -CH(CH3)-CH>=CH-CH>=CH2, -CH>=CH-CH2-C(CH3)>=CH2, -CH>=CH-CH(CH3)-CH>=CH2, -CH>=C(CH3)-CH2-CH>=CH2, -C(CH3)>=CH-CH2-CH>=CH2, -CH>=CH-CH>=C(CH3)2, -CH>=CH-C(CH3)>=CH-CH3, - CH>=C(CH3)-CH>=CH-CH3, -C(CH3)>=CH-CH>=CH-CH3, -CH>=C(CH3)-C(CH3)>=CH2, -C(CH3)>=CH-C(CH3)>=CH2, - C(CH3)>=C(CH3)-CH>=CH2, -CH>=CH-CH>=CH-CH>=CH2, -C≡CH, -C≡C-CH3, -CH2-C≡-CH, -C2H4-C≡CH, -CH2-C≡CCH3, -C≡C-C2H5, -C3H6-C≡CH, -C2H4-C≡C-CH3, -CH2-C≡C-C2H5, -C≡C-C3H7, -CH(CH3)-C≡CH, -CH2- CH(CH3)-C≡CH, -CH(CH3)-CH2-C≡CH, -CH(CH3)-C≡C-CH3, -C4H8-C≡CH, -C3H6-C≡C-CH3, -C2H4-C≡C-C2H5, - CH2-C≡C-C3H7, -C≡C-C4H9, -C2H4-CH(CH3)-C≡CH, -CH2-CH(CH3)-CH2-C≡CH, -CH(CH3)-C2H4-C≡CH, -CH2- CH(CH3)-C≡C-CH3, -CH(CH3)-CH2-C≡C-CH3, -CH(CH3)-C≡C-C2H5, -CH2-C≡CCH(CH3)2, -C≡C-CH(CH3)-C2H5, -C≡C-CH2-CH(CH3)2, -C≡C-C(CH3)3, -CH(C2H5)-C≡C-CH3,- C(CH3)2-C≡CCH3, -CH(C2H5)-CH2-C≡CH, -CH2- CH(C2H5)-C≡CH, -C(CH3)2-CH2-C≡CH, -CH2-C(CH3)2-C≡CH, -CH(CH3)-CH(CH3)-C≡CH, -CH(C3H7)-C≡CH, - C(CH3)(C2H5)-C≡CH, -C≡C-C≡CH, -CH2-C≡C-C≡CH, -C≡CC≡C-CH3, -CH(C≡CH)2, -C2H4-C≡C-C≡CH, -CH2- C≡C-CH2-C≡CH, -C≡C-C2H4-C≡CH, -CH2-C≡C-C≡C-CH3, -C≡C-CH2-C≡C-CH3, -C≡C-C≡C-C2H5, -C≡CCH( CH3)-C≡CH, -CH(CH3)-C≡C-C≡CH, -CH(C≡CH)-CH2-C≡CH, -C(C≡CH)2-CH3, -CH2-CH(C≡CH)2, -CH(C≡CH)- C≡C-CH3;, R21, R35, R36.