Patent SG-11201811479R-A (SG)
Title: An antibacterial composition and a method of treating staphylococcal infections with the antibacterial composition
Inventor: YOON SEONG JUN
IPC: A61K9/00
Filed: 2017-01-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101110111011101110111011111101111011111 International Bureau .. .... ..Yd j .n. ..1:2 (10) International Publication Number (43) International Publication Date WO 2017/122111 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 38/16 (2006.01) A61K 9/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/1B2017/050087 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 9 January 2017 (09.01.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 62/277,506 12 January 2016 (12.01.2016) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: INTRON BIOTECHNOLOGY, INC. kind of regional protection available): ARIPO (BW, GH, [KR/KR]; #1007, JungAng Induspia V, 138-6 Sangdae- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, won-Dong, Jungwon-Gu, Seongnam-Si, Gyeonggi-do, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 462-120 (KR). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: YOON, Seong Jun; #301 Shinhan Apt., DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Galak2-Dong, Songpa-Ku, Seoul, 138-807 (KR). JUN, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Soo Youn; #301 Shinhan Apt., Galak2-Dong, Songpa-Ku, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Seoul, 138-807 (KR). JUNG, Gi Mo; #301 Shinhan Apt., GW, KM, ML, MR, NE, SN, TD, TG). Galak2-Dong, Songpa-Ku, Seoul, 138-807 (KR). KANG, Published: — with international search report (Art. 21(3)) Sang Hyeon; #507-310 Jugong-5-danzi Apt., 27, Jam- sil-Dong, Songpa-Ku, Seoul, 138-225 (KR). — with sequence listing part of description (Rule 5.2(a)) (74) Agent: MIN, H. Timothy; SIMI, 1 Broadway, 14th Floor, Cambridge, Massachusetts 02142 (US). OF TREATING STAPHYLOCOCCAL INFECTIONS (54) Title: AN ANTIBACTERIAL COMPOSITION AND A METHOD WITH THE ANTIBACTERIAL COMPOSITION Figure 1 Staphylococcus arlettae Strain: KTC VMS iATCC 439571 (A) (B) reduction assay (0.5 Kim!) Spot-on-lawn assay Turbidity ..,,,,,. ..=ilii 1-1 1-1 1-1 1-1 0 N 1 , 1 ei ,-1 TOD = 13.0 IN 1-1 0 (57) : A method of treating staphylococcal infections includes administering to a subject an effective amount of an antibac - \" terial composition having a broad bactericidal activity. The antibacterial composition includes a first antibacterial protein consisting C of the amino acid sequence as set forth in SEQ. ID . NO: 1 and/or a second antibacterial protein consisting of the amino acid se - .• quence as set forth in SEQ. ID. NO: 2.