Patent SG-11201908457W-A (SG)
Title: Pharmaceutical compositions having high drug loadings of medium chain triglycerides and methods related thereto
Inventor: BADENOCH AARON M
IPC: A61K31/225
Filed: 2018-03-15
Abstract: W O 20 18/ 17 0 235 Al FIGURE 1 Add lipid., Pp.( mixture ip lipid mixtIre porpration ,essel Add AU:r and dorraetanta Add Si Ce-Sorramot 102 Add optional PPE ri r 4t solut,on preporation vessel OPTIONAL. Fl LM FORMING POLYMER ADDITION Optional Nat Forming Polymer 106 ADSORBENT AM Add pdporbont preptootiop ,oppol Adsorbent 108 PREPARATION OP LIPID.MIXTURE SOLVENT\" ADDITION Add Solvent 101 LIPID MIXTURE ADDITION preyeretloit easel to for •, Llold Munro 110 -CY SPRAY-DRYING Spew dry fowl solution pr,aradon in spray Mar with dosirod spray dry patatocto, Spray Dry (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo olomolimill onno oimIE (10) International Publication Number WO 2018/170235 Al (51) International Patent Classification: A61K 9/14 (2006.01) A61K 31/23 (2006.01) A61K 31/225 (2006.01) (21) International Application Number: PCT/US2018/022594 (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,836 15 March 2017 (15.03.2017) US (71) Applicant: ACCERA, INC. [US/US]; 2443 S. University Blvd #234, Denver, Colorado 80210 (US). (72) Inventors: BADENOCH, Aaron M.; 20259 Schaeffer Drive, Bend, Oregon 97703 (US). BOIVIN, Taryn; 2275 132A St., Surrey, British Columbia V4A 9W5 (CA). DUBOSE, Devon B.; 18696 Kuhlman Rd., Bend, Ore- gon 97703 (US). HENDERSON, Samuel T.; 29809 Hwy 72, Golden, Colorado 80403 (US). HOSTETLER, Christi Lynn; 61435 Rock Bluff Lane, Bend, Oregon 97702 (US). LYON, David K.; 20448 Klahani Dr., Bend, Oregon 97702 (US). SATHER, Craig A.; 20635 Sierra Dr., Bend, Oregon 97701 (US). SHAFFER, Matthew J.; 64590 Deschutes Market Rd., Bend, Oregon 97701 (US). (74) Agent: VINNOLA, Milan M. et al.; 1401 Lawrence Street, Suite 2300, Denver, Colorado 80202 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: PHARMACEUTICAL COMPOSITIONS HAVING HIGH DRUG LOADINGS OF MEDIUM CHAIN TRIGLYCERIDES AND METHODS RELATED THERETO (57) : This invention relates to high drug load compositions of medium chain triglycerides (MCT), and to methods for treatment with such compositions at amounts effective to elevate ketone body concentrations so as to treat conditions associated with reduced neuronal metabolism, for example Alzheimer's disease. [Continued on next page] WO 2018/170235 Al MIDEDIMOMMIONEEMOMMENIMIMOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))