Patent SG-11201903062T-A (SG)
Title: Light diffusing devices for use in photoimmunotherapy
Inventor: ROSE ANDREAS
IPC: F21V8/00
Filed: 2017-10-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 011101011M 01 1101010 11111111 01101111110101111110 ill 011 Organization (10) International Publication Number International Bureau (43) International Publication Date ......0\"\"1 WO 2018/080952 Al 03 May 2018 (03.05.2018) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) International Patent Classification: (71) Applicant: ASPYRIAN THERAPEUTICS INC. F21V 8/00 (2006.01) A61B 18/22 (2006.01) [US/US]; 10581 Roselle Street, Suite 115, San Diego, CA GO2B 6/02 (2006.01) 92121 (US). International Application Number: (72) Inventors: ROSE, Andreas; Zepperweg 3, 35745 Her- PCT/US2017/057787 born (DE). JOHNSTON, Kyle; 21819 NE 1st Street, Sam- International Filing Date: mamish, WA 98074 (US). BIEL, Merrill; 2563 Delaware 23 October 2017 (23.10.2017) Avenue, Mendota Heights, MN 55118 (US). English (74) Agent: LEE, Jenny et al.; The Dobrusin Law Firm, PC, 29 W. Lawrence Street, Suite 210, Pontiac, MI 48342 (US). Publication Language: English (81) Designated States (unless otherwise indicated, for every Priority Data: kind of national protection available): AE, AG, AL, AM, 62/412,606 25 October 2016 (25.10.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/529,507 07 July 2017 (07.07.2017) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) (57) C proximal GO diffusing Title: LIGHT DIFFUSING DEVICES FOR USE IN PHOTOIMMUNOTHERAPY = / 100 12 11 19 Tha 0 ' 10 16 18 HI 18 17 FIG. • 0-0-9M0-0' 1 1-1 N having Il ln frontal 01 C ::: :) radially 0 .-- b - non 1-1 c:::: , and ei -circular core fiber section (604) and a lens (606), wherein the non-circular core section has a \"top hat\" core irradiance distribution : The present invention provides a cylindrical light diffusing device (300) comprising a non-circular core fiber (302) (i) a fiber core (350) that provides a \"top hat\" core irradiance distribution; optionally (ii) light blocking means (314) that prevent light emisson from distal end of the non-circular core fiber (302); and (iii) a light diffusing section (308) having a diffusing end (310), a diffusing distal end (312), and internal scattering features (362) distributed within the fiber core (350) of the light section (308) along central axis (364) of the fiber core (350), wherein the light diffusion section (308) emits irradiance in a symmetric longitudinally \"top hat\" diffusing irradiance distribution. The disclosure also provides a device (600) comprising a the device provides a \"top hat\" spectral irradiance distribution at a targeted location. The disclosure also provides a devie (700) C [Continued on next page] WO 2018/080952 Al MIDEDIMOMMIONERIONIMMONIHEIHIMEHOIMIE MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) comprising an optical fiber (702) and a collimation lens assembly (704) that includes a variable aperture (714) that blocks portions of light outcoupled from the optical fiber thereby allowing only a central portion of the light to exit from the variable aperture resulting in a flat irradiance distribution.