baber/WOPTO huggingface dataset:
Patent IE-780285-L (IE)
Title: PROCESS FOR THE PREPARATION OF d,l -5-METHYLTETRAHYDROFOLIC¹ACID
IPC: A61K47/18
Filed: 1978-02-09
Abstract: Process for the preparation of d,l-5-methyltetrahydrofolic acid and its salts of the formula 1 in which X is hydrogen, an alkali metal or the equivalent of an alkaline earth metal, by reduction of folic acid with NaBH4 and methylation of the tetrahydrofolic acid obtained with aqueous solutions of formaldehyde and sodium borohydride in an inert gas atmosphere. The process is simple and can be carried out without separation of intermediates while carrying out the process steps successively in the same reaction vessel. The final products are obtained in a yield of more than 80%, relative to folic acid employed, in a purity of more than 99%. The compounds of the formula I obtained are non-toxic, stable at physiological pH and suitable for the preparation of liquid or solid pharmaceutical compositions for any type of application in human therapy. Such compositions exhibit haematopoietic action, hepatoprotective and antineoplastic action. <IMAGE>
[GB1572137A]
Patent IE-42644-L (IE)
Title: Indolyl-guanidines.
IPC: C07D209/04
Filed: 1976-02-25
Abstract: Compounds of the formula I <IMAGE> in which the individual substituents have the meanings stated in the claim, are prepared. The process is based on replacement of an -SR9 group in which R9 denotes lower alkyl by the -NR2R3 group. The resulting products of the formula I and their acid addition salts have antihypertensive properties and properties increasing venous tone.
[GB1531611A]
Patent IE-820431-L (IE)
Title: Mitomycin derivatives
IPC: A61K31/40
Filed: 1982-02-26
Abstract: Compounds of the formula, II <IMAGE> wherein: Y is hydrogen or lower alkyl; and X is a lower alkoxy substituted quinolinylamino radical, a cyano substituted pyrazolylamino radical or a mono-or di-lower alkyl substituted thiazolamino radical, or a nitrogen-containing heterocyclic radical selected from the group consisting of 1-pyrrolinyl, 1-indolinyl, N-thiazoladinyl and N-thiomorpholinyl radicals, or a cyano, phenyl, carboxamido or lower alkoxycarbonyl substituted 1-aziridinyl radical, or a lower alkyl, formyl or acetylphenyl substituted 1-piperazinyl radical, or an hydroxy piperidyl substituted 1-piperidyl radical, or a lower alkoxy, amino or halo substituted pyridylamino radical, or a carboxamido, mercapto or methylenedioxy substituted anilino radical, or a radical of the formula, <IMAGE> wherein R is hydrogen or lower alkyl and R' is a nitrogen-containing heterocyclic radical selected from the group consisting of quinuclidinyl, pyrazolyl, 1-triazolyl, isoquinolinyl, indazolyl, benzoxazolyl, thiadiazolyl and benzothiadiazolyl, and lower alkyl and halo substituted derivatives thereof, or a butyrolactonyl radical, or an adamantyl radical, or a substituted lower alkyl radical selected from the group consisting of mercapto lower alkyl, mono-, di- and tri-lower alkoxy lower alkyl, lower alkyl thio lower alkyl and lower alkoxycarbonyl substituted derivatives thereof, cyano lower alkyl, mono-, di- and tri-lower alkoxy phenyl lower alkyl, phenyl cyclo lower alkyl, 1-pyrrolidinyl lower alkyl, N-lower alkyl pyrrolidinyl lower alkyl, and N-morpholinyl lower alkyl. These compounds are used for treatment of neoplastic disease states in animals.
[GB2106096A]
Patent IE-850447-L (IE)
Title: Ophthalmic lenses
IPC: G02B3/00
Filed: 1985-02-22
Abstract: A contact or spectacle or implant lens has positive diffractive power which introduces negative longitudinal chromatic aberration that more than counteracts, and is preferably greater than twice, the natural positive longitudinal chromatic aberration of the eye. The residual negative longitudinal chromatic aberration enables the eye/brain system to perform tasks by concentrating on the appropriate color component at the different respective distances without need to accommodate.
[US4655565A]
Patent IE-890603-L (IE)
Title: Wettable, rigid gas permeable, substantially non-swellable contact lens
IPC: G02B1/04
Filed: 1989-02-24
Abstract: This invention relates to ophthalmic devices, such as contact lenses and intraocular implants, and particularly contact lenses of a block copolymer containing polysiloxane and polyoxyalkylene oxide units possessing an advantageous blend of desirable properties including a) high oxygen permeability, b) good wettability, c) optical clarity and d) a substantially lack of aqueous swellability in the ocular environment of use. Even the preparation thereof and methods of treating vision defects therewith are disclosed as well as the polymers suitable for these ophthalmic devices.
Patent IE-830636-L (IE)
Title: Interpolymer latex
IPC: C08F279/02
Filed: 1983-03-23
Abstract: Latex of an interpolymer composed of (1) a copolymer A of butadiene, styrene and at least one ethylenically unsaturated carboxylic acid, and (2) a polymer B of a halogenohydroxyalkyl ester of an ethylenically unsaturated monocarboxylic or dicarboxylic acid, polymer B being at least partially grafted onto the copolymer A. The latex is prepared by the emulsion polymerization of butadiene, styrene and at least one copolymerizable, ethylenically unsaturated carboxylic acid, followed by the polymerization, in the presence of the copolymer latex, of a halogenohydroxyalkyl ester of an ethylenically unsaturated monocarboxylic or dicarboxylic acid. The latex may be used as a binder in aqueous compositions for coating paper.
Patent IE-840764-L (IE)
Title: Knitted surgical swab.
IPC: A61F13/00
Filed: 1984-03-28
Abstract: A surgical swab comprises a warp knitted body portion (1) and an integrally warp knitted handling tape (3). Both the body portion and the handling tape are formed as two superimposed layers on a twin needle bed knitting machine, the respective longitudinal and/or laterally extending edges of each layer being joined by interknitting.The swab may be cut from a continuous swab strip which is formed by continuously knitting a Inegth of body portion fabric and of handling tape fabric with a lateral band of the fabrics being knitted together at intervals. Individual swabs are separated from the strip by cutting through the lateral band.
Patent IE-41108-L (IE)
Title: Amides and their use as fungicides
IPC: C07C231/00
Filed: 1975-04-08
Abstract: 1500576 Amides CIBA-GEIGY AG 8 April 1975 [9 April 1974 7 March 1975] 14379/75 Heading C2C The invention comprises compounds of the formula wherein R 1 represents a halogen atom or an alkyl or alkoxy group of 1 to 4 carbon atoms, R 2 represents a hydrogen or halogen atom, an alkyl group of 1 to 3 carbon atoms or an alkoxy group of 1 to 4 carbon atoms, R 3 represents a hydrogen atom, or a methyl or ethyl group, R 4 represents an alkyl group of 1 to 6 carbon atoms unsubstituted or substituted by cyano (-CN) or rhodano (-SCN), an alkenyl group of 2 to 5 carbon atoms or a cycloalkyl group of 3 to 7 carbon atoms, R 5 represents a hydrogen or halogen atom, or an alkyl group of 1 to 3 carbon atoms, and R 6 represents a hydrogen atom or a methyl group, the total number of carbon atoms in the substituents R 1 , R 2 , R 5 and R 6 not exceeding 8. The compounds may be prepared by acylating a compound of the formula with a compound of the formula HO-CO-R 4 or with a reactive derivative thereof, or by converting a compound of the formula with butyl lithium or sodium hydride into the corresponding alkali salt which is then reacted with a compound of the formula where Hal is halogen or another easily removable radical, or by reacting the compound of Formula IV with Hal-CH(CH 3 )-COOR 3 in the presence of an alkali carbonate.
[GB1500576A]
Patent FI-830107-L (FI)
Inventor: MANHART MICHAEL
IPC: B05B7/04
Filed: 1983-01-12
Abstract: 1. Snow gun having a central compressed-air supply line (1) and a pressurized-water supply line surrounding the latter and disposed coaxially therewith, the compressed-air supply line opening out into an interior space of a spray-head (7) at the front, in the direction of the compressed air supply, the space being bounded by a bored endpiece (8) and serving as a preexpansion chamber (9), inner nozzles (4) in the form of bores passing through the outside wall of the compressed-air supply line (1) being provided between the compressed-air supply line (1) and the pressurized-water supply line, through which nozzles the compressed air issues into the pre-expansion chamber (9) and mixes with the pressurized-water, characterized in that the compressed-air supply line (1) has three identical inner nozzles (4), and the endpiece has three centrosymmetrically disposed discharge nozzles (10) of identical diameter, none of which is situated in the geometric axis of the compressed-air supply line (1), and the diameter of a discharge nozzle (10) corresponds to 1 to 3 times the diameter of an inner nozzle (4).
Patent IE-45197-L (IE)
Title: Pharmaceutical composition
IPC: A61P7/06
Filed: 1977-05-16
Abstract: PHARMACEUTICAL COMPOSITION CONTAINING A HYDROGENATED ERGOT ALKALOID AND ETILEFRIN The invention provides novel pharmaceutical compositions useful as venotonics, comprising a mixture of dihydroergotamine or a related ergot alkaloid and etilefrin.
[CA1088865A]
Patent IE-44255-L (IE)
Title: Esters of prostan-1-ol
IPC: A61K31/27
Filed: 1976-05-24
Abstract: Prostan-1-ol esters and intermediates for their preparation are described; the former compounds exhibit improved organ specificity and a longer duration of activity at lower dosages than the corresponding non-esterified prostaglandins and are useful, inter alia, in triggering abortion, inducing labor and regulating the menstrual cycle.
[US4256745A]
Patent IE-45160-L (IE)
Title: Bead reinforceing in pneumatic tyres.
IPC: B60C9/02
Filed: 1977-07-07
Abstract: A pneumatic vehicle tire having a single layer radial carcass of steel or a material of similarly high strength. The carcass is anchored by being looped around the bead cores in the beads. The laterally outwardly lying free ends of the carcass layer may extend up to about half the height of the tire side walls. Laterally outwardly, next to the looped around carcass end, between the rim flange and this carcass end, there is provided a bead reinforcer which includes pull-resistant threads or the like which are parallel to one another. The bead reinforcer is slanted with regard to the carcass, preferably extending at an angle of about 15 DEG to 45 DEG to the circumferential direction of the tire. The radially outwardly lying free end of the bead reinforcer has associated therewith a strip which extends parallel to said free end and includes pull-resistant threads or the like which are arranged in a cord layer. These threads are likewise slanted with regard to the circumferential direction of the tire, preferably forming an angle of about 15 DEG to 45 DEG with the circumferential direction, but, with regard to the bead reinforcer, are oppositely slanted, i.e. cross the threads of the bead reinforcer, in such a way that the freely ending, laterally looped around carcass end forms with the bead reinforcer and this strip a triangular formation which practically maintains the mutual spacing of the carcass strength carriers and the strength carriers of the bead reinforcer. (From US4234029 A) [FR2357386A1]
Patent IE-36785-L (IE)
Title: Dentifrice
IPC: A61Q11/00
Filed: 1972-10-19
Abstract: 1400154 Dentifrice UNILEVER LTD 17 Oct 1972 [22 Oct 1971] 49321/71 Heading A5B A clear dentifrice contains (a) a solid phase comprising a particulate material of refractive index 1.44 to 1.48 and (b) a liquid phase having the same refractive index as the solid phase and comprising an aqueous solution of maltodextrins and glycerol or sorbitol as humectant. The solid particles may be silica xerogel. The composition may also comprise silica aerogel as thickener, sodium carboxymethyl cellulose, sodium lauryl sulphate, soluble saccharin, polyethylene glycol, flavouring and colouring.
[GB1400154A]
Patent IE-36854-L (IE)
Title: Anaesthetic
IPC: C07J41/00
Filed: 1971-12-16
Abstract: 1380247 Esters of 3α-hydroxy-5#-pregnanes GLAXO LABORATORIES Ltd 16 Dec 1971 [17 Dec 1970] 60069/70 Heading C2U [Also in Division A5] 3α - (DL - 2 - aminwaleryloxy) - 5# - pregnane- 11,20-dione hydrochloride. DL-N-benzyloxycarbonyl-norvaline and N,N-carbonyldiimidazole are refluxed together in presence of tetrahydrofuran. Then 3α-hydroxy-5#-pregnane-11,20-dione is added and the reflux continued. Crystalline 3α-(DL-2-benzyloxycarbonylaminovaleryloxy) - 5# - pregnane - 11,20- dione is recovered from the reaction mixture. Hydrogenation of a dioxane solution of thiocrystalline material, in presence of hydrochloric acid, water and palladium-on-carbon catalyst yields 3α-(DL-2-aminovaleryloxy)-5#- pregnane-11,20-dione hydrochloride. 3α - (N - [2 - Hydroxyethyl] - DL - alanyloxy)- 5# - pregnane - 11,20 - dione hydrochloride a solution of 3α-hydroxy-5#-pregnane-11,20-dione in methylene dichloride is treated with 2- bromopropionylchloride and pyridine and crystalline 3α - (DL - 2 - bromopropionyloxy) - 5#- pregnane-11,20-dione is recovered from the reaction mixture. A solution of the crystalline material in acetonitrile is treated with 2- hydroxyethylamine. After removal of solvent and partitioning between ether and water, the organic phase is separated and extracted with 2N-hydrochloric acid. From the aqueous acid solution there is recovered 3α-(N-[2-hydroxyethyl] - DL - alanyloxy) - 5# - pregnane - 11,20- dione hydrochloride.
[GB1380247A]
Patent IE-901790-L (IE)
Title: Aryloxyphenylpropylamines their preparation and use
IPC: A61K31/275
Filed: 1990-05-18
Abstract: Novel aryloxyphenylpropylamines having the formula <CHEM>  wherein X is H, cyano, halogen, halogenoalkyl, C1-6-alkoxy, C1-6-alkyl, C1-5-alkanoyl, C3-5-alkylene, aryloxy or aralkoxy, and R is 3,4-methylenedioxy, aryl or heteroaryl which are optionally substituted with one or more cyano, halogeno, C1-6-alkyl, C1-6-alkoxy, C1-6-alkenyl, trifluoromethyl, C3-5- alkylene, aryloxy or aralkoxy: and R<1> and R<2> independently is C1-10-alkyl, C3-7-cycloalkyl, C2-10-alkenyl, C3-6-cycloalkyl-C1-5-alkyl, optionally substituted with C1-5-alkoxy or cyano;  or R<1> and R<2> may together form a carbocyclic ring and a salt thereof with a pharmaceutically acceptable acid, provided however that R<1> is not C3-7-cycloalkyl, C1-10-alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4-alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl, when X is H and R<2> is a methyl group. The novel compounds are useful in the treatment of anoxia, migraine, ischemia, epilepsy, traumatic injury and neurodegenerative diseases.
Patent IE-41840-L (IE)
Title: Cultivation of plants.
IPC: A01G31/04
Filed: 1975-08-12
Abstract: The method provides that in each case one seed kernel is sown in a cultivating bed, and the beds are situated closely together during the germination of the seed kernels. Thereafter, the beds are moved onto a conveyor belt (4) and pushed forwards in a cultivating channel (11). In the cultivating channel, the substances necessary for growth are supplied and drained at the base of the channel. The distance between the beds is enlarged in step with the increasing need of the plants for space during growth.
Patent IE-872009-L (IE)
Title: Removing cyanogen halides and phosgene from waste gases
IPC: B01D53/34
Filed: 1987-07-24
Abstract: 1. A process for removing cyanogen halides and/or phosgene from waste gases by washing with aqueous solutions of bases, wherein the waste gas containing the cyanogen halide and/or phosgene is brought into intimate contact with a wash liquid which contains as active component an amine of the formula NR3 in which one of the radicals R represents an alkanol group having 2 or 3 carbon atoms and the remaining R groups are alkyl having 1 to 4 carbon atoms.
Patent IE-872199-L (IE)
Title: Platinum derivatives and cancer treatments
IPC: C07F15/00
Filed: 1987-08-17
Abstract: Derivatives of platinum group metals, particularly platinum itself, wherein the metal is linked to one or more pharmaceutically acceptable steroid, fatty acid or other lipophilic residues aiding transport of the metal across cell membranes in the body, particularly fatty acid amine or fatty acid amide groups RCH2NH- or <CHEM> where R is a hydrocarbon group, suitably of 10 to 30 carbon atoms. The derivatives are useful in the treatment of cancer.
Patent IE-842501-L (IE)
Title: Administering growth hormone to increase milk production
IPC: A61K38/27
Filed: 1984-10-02
Abstract: This invention relates to the administration of growth hormone to a ruminant between about the onset of puberty to about first parturition, thereby increasing the quantity of mammary parenchyma, resulting in increased milk production during subsequent lactations.
Patent IE-872653-L (IE)
Title: Cationically curable compositions
IPC: C08G16/02
Filed: 1987-10-05
Abstract: Cationically curable compositions comprise: A (i) phenols and phenoxy silyl ethers of the formula <CHEM> wherein Ra and Rb (which may be the same or different) are H or an ortho, para directing activating group for aromatic electrophilic substitution, other than an amine; provided that Ra and Rb are not both H; X is hydroxy or <CHEM> wherein R1 and R2 are H, hydrocarbyl having 1-5 carbon atoms, or aryl R3 is H, hydrocarbyl, aryl, hydrocarbylaryl or a halogen-substituted derivative thereof; A (ii) phenol ethers of the formula <CHEM> wherein R4, R5 and R6 which may be the same or different are hydrocarbyl, aryl, hydrocarbylaryl, or a substituted derivative thereof; A (iii) ethers of hydroquinone of the formula <CHEM> wherein R4 and R5 are as defined above; A (iv) substituted phenol ethers of the formula <CHEM> wherein R4 and R5 are as defined above and R7 is -C(O)-NH-R8-NH-C(O)- or -C(O)-R8-C(O)- wherein R8 is a divalent aliphatic, cycloaliphatic or aromatic group; A (v) phenolic compounds of the formula <CHEM> wherein Ra and X are as defined herein Ra is an n-valent radical and 2 </= n </= 4 a compound B selected from B (i) formaldehyde; and compounds capable of producing formaldehyde in the presence of an acid; B (ii) monofunctional aldehydes other than formaldehyde; and compounds capable of producing such aldehydes in the presence of acid B (iii) multi-functional aldehydes; and compounds capable of producing such aldehydes in the presence of acid; a compound C which is a latent acid catalyst, activatable by radiation, heat or moisture. The compositions can be stored and applied (for example in coatings, sealants and adhesives) in the liquid condition, and then cured directly to a solid condition.
[EP0311371A2]
Patent NO-793186-L (NO)
Inventor: BOSLEY JOHAN ANTHONY
IPC: A61L15/00
Filed: 1979-10-04
Abstract: Water-swellable particulate absorbents have improved dispersibility in blood by surface-treatment with a hydrocarbon compound which is an aliphatic hydrocarbon or a substantially nonionic derivative thereof which is non-volatile and has a melting point below 35 DEG C, or is a C12-C18 alkyl trimethylammonium halide. Examples of suitable aliphatic hydrocarbons are n-dodecane, n-hexadecane; n-heptadecane and n-octadecane. Preferred derivatives are fatty alcohols, fatty acids and fatty acid esters.
Patent NO-801267-L (NO)
Inventor: MIZZONI RENAT HERBERT
IPC: C07D213/65
Filed: 1980-04-30
Abstract: There is described a process for preparing an enamine of formula (IX):   <IMAGE> where R<2> is a carboxylic acid protecting group and R<3> is the residue of a carboxylic acid derived acyl group and where R<5> and R<6> are the same or different C1-4 alkyl or C1-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII):   <IMAGE> with an amine of formula HNR<5>R<6>, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3- hydroxycephalosporins. The compounds of formula (XII) are novel.
Patent NO-833583-L (NO)
Inventor: SAUDER KARL
IPC: F16K39/02
Filed: 1983-10-03
Abstract: A hydraulic control device consists of a housing, a control slide valve displaceable in a bore of the housing, and a control ring. Axial displacement of the control slide valve makes it possible to connect together or to disconnect various connecting lines depending upon the position of the valve. Located in an annular chamber, formed between a section of the housing bore and the control slide valve is a control ring arranged coaxially with the valve and guided displaceably thereupon. Valve seats are spaced axially from each other both in the housing bore and on the control slide valve. The control ring comprises inner mating surfaces and outer mating surfaces cooperating with the valve seats. Provided between the two valve seats in the control slide valve is a flow channel running therein which is closed at one end depending upon the position of the control ring. The latter is held by the pressure of the flowing medium in the appropriate closed position, but the changeover may be effected independently of the pressure since no axial forces are applied to the control slide valve by the flowing medium.
Patent NO-863980-L (NO)
Inventor: HASHIMOTO MASASJI
IPC: C07D239/96
Filed: 1986-10-06
Abstract: A compound of the formula: 
<CHEM>
 in which
 R<1> and R<2> are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,
 R<3> is aryl or ar(lower)alkyl, both of which may have one or more suitable substituent(s), or heterocyclic(lower)alkyl,
 R<4> is carboxy or protected carboxy,
 A is oxygen or sulfur atom,
 Y is carbonyl, thiocarbonyl or sulfonyl and
 Z is lower alkylene,
 and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them in admixture with pharmaceutically acceptable carriers.
Patent NO-864187-L (NO)
Inventor: GERDES WILLIAM H
IPC: B01J29/06
Filed: 1986-10-20
Abstract: A catalyst for the selective reduction of nitrogen oxides to nitrogen in the presence of ammonia in the form of composite bodies formed from a mixture of anatase (5 to 40% by weight), a zeolite (50 to 90%), a bond material (0 to 30%, and, optionally, promoter which is an oxide of vanadium, molybdenum, or copper, in the amount of at least 0.1% by weight.
Patent NO-865190-L (NO)
Inventor: KAPMEYER WOLFGANG
IPC: C07K17/08
Filed: 1986-12-19
Abstract: Dispersion polymers which are used to prepare active dispersion polymers (latex conjugates) are obtained by polymerising compounds of the formula I
 H2C=C(R1)-CO-NH-(CH2)n-CH(OR2)(OR3)
 in which n is 1 to 6, R1 is H or CH3, and R2 and R3 are identical or different and are -(CH2)m-CH3 where m is 0 to 7 or are CY(X)(Z) where X, Y and Z are identical or different and are (CH2)pCH3 where p is 1 to 3,
 and compounds of the formula II
 H2C=C(R1)-CO-R-(CH2)n-(CHOH)m-(CH2)1-H
 in which R is O or NH, n is 1 to 3, m is 1 to 4, l is 0 to 4 and R1 is H or CH3,
 with one another in the presence of a seed dispersion, a copolymer being formed on the surface of the latex particles. 
<??>Latex conjugates are obtained therefrom by binding the antibodies or antigens of interest to the dispersion polymers according to the invention.