Patent EA-002004-B1 (EA)
Title: Composition for use in ophthalmologic surgeries (variants) and method therefor
Inventor: GALIN MILES A
IPC: A61K31/765
Filed: 1998-03-18
Abstract: 1. A composition for use in ophthalmologic surgery comprising a viscoelastic polymer and an effective amount of an anesthetic agent. 2. The composition of Claim 1, wherein the viscoelastic polymer is acidic and the anesthetic agent is alkaline. 3. The composition of Claim 1, wherein the viscoelastic polymer is anionic and the anesthetic agent is cationic. 4. The composition of Claim 1, wherein the viscoelastic polymer and the anesthetic agent form a viscoelastic polymer-anesthetic complex. 5. A composition for use in ophthalmology surgery comprising a viscoelastic polymer, an anesthetic agent, and a drug, wherein the viscoelastic polymer, the anesthetic agent, and the drug form an ionic viscoelastic polymeranesthetic-drug complex, wherein the drug is selected from the group consisting of miotic and mydriatic agents. 6. The composition of Claim 5, wherein the miotic and mydriatic agents are selected from the group consisting of atropine, pilocarpine, phenylephrine, isopilocarpine, acetylcholine, atropine sulfate, pilocarpine hydrochloride, phenylephrine hydrochloride, acetylcholine chloride, pilocarpine hydrochloride, and isopilocarpine hydrochloride. 7. The composition of Claim 1, wherein the viscoelastic polymer is selected from the group consisting of one or more of hyaluronic acid, chondroitin sulfate, dermatan sulfate, carboxymethylcellulose, heparan sulfate, heparin, keratan sulfate, carboxymethylhydroxy-ethylcellulose, cellulose sulfate, cellulose phosphate, carboxymethylguar, carboxymethylhydroxypropylguar, xanthan gum, gellan gum, welan gum, rhamsan gum, agarose, alginates, furcellaran, pectins, gum arabic, gum tragacanth, carrageenans, starch phosphates, starch succinates, glycoaminoglycans, polysaccharides, polypeptides, and polymers and copolymers of acrylamide, N-vinylpyrrolidone, dimethylacrylamide, acrylic acid, methacrylic acid, maleic anhydride, vinylsulfonic acid, styrenecarboxylic acid, 2-acrylamido-2-methylpropanesulfonic acid, vinylphosphonic acid, and 2-methacryloyloxyethylsulfonic acid. 8. The composition of Claim 5, wherein the viscoelastic polymer is selected from the group consisting of one or more of hyaluronic acid, chondroitinsulfate, dermatan sulfate, carboxymethylcellulose, heparan sulfate, heparin, keratan sulfate, carboxymethylhydroxy-ethylcellulose, cellulose sulfate, cellulose phosphate, carboxymethylguar, carboxymethylhydroxypropylguar, xanthan gum, gellan gum, welan gum, rhamsan gum, agarose, alginates, furcellaran, pectins, gum arabic, gum tragacanth, carrageenans, starch phosphates, starch succinates, glycoaminoglycans, polysaccharides, polypeptides, and polymers and copolymers of acrylamide, N-vinylpyrrolidone, dimethylacrylamide, acrylic acid, methacrylic acid, maleic anhydride, vinylsulfonic acid, styrenecarboxylic acid, 2-acrylamido-2-methylpropanesulfonic acid, vinylphosphonic acid, and 2-methacryloyloxyethylsulfonic acid. 9. The composition of Claim 1, wherein the anesthetic agent is selected from the group consisting of lidocaine, proparacaine, tetracaine, phenacaine, naepaine, cocaine, betoxycaine, bupivacaine, butacaine, butanilicaine, butoxycaine, carticaine, cyclomethycaine, dibucaine, dimethocaine, etidocaine, formcaine, hexylcaine, hydroxytetracaine, leucinocaine, mepivacaine, meprylcaine, metabutoxycaine, myrtecaine, octacaine, orthocaine, oxethazine, parethoxycaine, piperocaine, piridocaine, pirilocaine, procaine, propanocaine, propipocaine, propoxycaine, pseudocaine, pyrrocaine, ropivacaine, tolylcaine, tricaine, and trimecaine. 10. The composition of Claim 5, wherein the anesthetic agent is selected from the group consisting of lidocaine, proparacaine, tetracaine, phenacaine, naepaine, cocaine, betoxycaine, bupivacaine, butacaine, butanilicaine, butoxycaine, carticaine, cyclomethycaine, dibucaine, dimethocaine, etidocaine, formcaine, hexylcaine, hydroxytetracaine, leucinocaine, mepivacaine, meprylcaine, metabutoxycaine, myrtecaine, octacaine, orthocaine, oxethazine, parethoxycaine, piperocaine, piridocaine, pirilocaine, procaine, propanocaine, propipocaine, propoxycaine, pseudocaine, pyrrocaine, ropivacaine, tolylcaine, tricaine, and trimecaine. 11. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is lidocaine. 12. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is lidocaine. 13. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is tetracaine. 14. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is tetracaine. 15. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is proparacaine. 16. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is proparacaine. 17. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is phenacaine. 18. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is phenacaine. 19. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is cocaine. 20. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is cocaine. 21. The composition of Claim 1 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is naepaine. 22. The composition of Claim 5 wherein the viscoelastic polymer is hyaluronic acid and the anesthetic agent is naepaine. 23. The composition of Claim 1, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is lidocaine hydrochloride. 24. The composition of Claim 5, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is lidocaine hydrochloride. 25. The composition of Claim 1, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is proparacaine hydrochloride. 26. The composition of Claim 5, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is proparacaine hydrochloride. 27. The composition of Claim 1, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is phenacaine hydrochloride. 28. The composition of Claim 5, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is phenacaine hydrochloride. 29. The composition of Claim 1, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is cocaine hydrochloride. 30. The composition of Claim 5, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is cocaine hydrochloride. 31. The composition of Claim 1, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is naepaine hydrochloride. 32. The composition of Claim 5, wherein the viscoelastic polymer is sodium hyaluronate and the anesthetic agent is naepaine hydrochloride. 33. The composition of Claim 5, wherein the complex is selected from the group consisting of atropine-lidocaine-hyaluronate, atropine-proparacaine hyaluronate, atropine-tetracaine hyaluronate, atropine-phenacaine hyaluronate, atropine-cocaine hyaluronate, atropine-naepaine hyaluronate, atropine-lidocaine chondroitinsulfate, atropine-proparacaine chondroitinsulfate, atropine-tetracaine chondroitinsulfate, atropine-phenacaine chondroitinsulfate, and atropine-naepaine chondroitinsulfate. 34. The composition of Claim 5, wherein the complex is selected from the group consisting of acetylcholine-lidocaine hyaluronate, acetylcholine-proparacaine hyaluronate, acetylcholine-tetracaine hyaluronate, acetylcholine-phenacaine hyaluronate, acetylcholine-cocaine hyaluronate, acetylcholine-naepaine hyaluronate, acetylcholine-lidocaine chondroitinsulfate, acetylcholine-proparacaine chondroitinsulfate, acetylcholine-tetracaine chondroitinsulfate, acetylcholine-phenacaine chondroitinsulfate, and acetylcholine-naepaine chondroitinsulfate. 35. The composition of Claim 5, wherein the complex is selected from the group consisting of pilocarpine-lidocaine hyaluronate, pilocarpine-proparacaine hyaluronate, pilocarpine-tetracaine hyaluronate, pilocarpine-phenacaine hyaluronate, pilocarpine-cocaine hyaluronate, pilocarpine-naepaine hyaluronate, pilocarpine-lidocaine chondroitinsulfate, pilocarpine-proparacaine chondroitinsulfate, pilocarpine-tetracaine chondroitinsulfate, pilocarpine-phenacaine chondroitinsulfate, and pilocarpine-naepaine chondroitinsulfate. 36. A method of maintaining the structural integrity of the anterior chamber of the eye during surgery while concurrently providing anesthesia, comprising administering a viscoelastic polymer and a therapeutically effective amount of an anesthetic agent to be administered to a subject in need thereof.