Patent SG-11202000266V-A (SG)
Title: Quinoline derivatives for treating infections with helminths
Inventor: GRIEBENOW NILS
IPC: C07D413/14
Filed: 2018-07-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau vitivio VIII oviolo olliviontoo mil mu oimIE (43) International Publication Date 07 February 2019 (07.02.2019) (10) International Publication Number WO 2019/025341 Al WIPO I PCT (51) International Patent Classification: CO7D 405/14 (2006.01) CO7D 417/04 (2006.01) CO7D 413/14 (2006.01) A61P 33/00 (2006.01) CO7D 401/04 (2006.01) A61K 31/4709 (2006.01) CO7D 413/04 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: 30 July 2018 (30.07.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17185001.9 04 August 2017 (04.08.2017) EP (71) Applicant: BAYER ANIMAL HEALTH GMBH [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen (DE). (72) Inventors: GRIEBENOW, Nils; Kurfiirstenstr. 39, 41541 Doiinagen (DE). ZHUANG, Wei; Stauffenbergstr. 13, 40789 Monheim (DE). KULKE, Daniel; Dillinger Str. 13, 51375 Leverkusen (DE). BOHM, Claudia; Im Seefelde 4a, 30457 Hannover (DE). SCHWARZ, Hans-Georg; Auf dem Beerenkamp 82b, 46282 Dorsten (DE). HUBSCH, Walter; Wildsteig 22, 42113 Wuppertal (DE). ILG, Thomas; Plotzenseer Str. 16, 40789 Monheim (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PCT/EP2018/070552 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art 21(3)) (54) Title: QUINOLINE DERIVATIVES FOR TREATING INFECTIONS WITH HELMINTHS (57) : The present invention covers quinoline compounds of general formula (I), in which A, cr\ C 1-1 R5 S A R R 3 R 1 , R , R , R , R , R 2 3 4 5 6 , and Q are as defined herein, methods of preparing said compounds, intermediate (I) compounds useful for preparing said compounds, pharmaceutical compositions and combinations com- prising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.