baber/WOPTO huggingface dataset:
Patent EP-4146682-A1 (EP)
Title: Récepteur antigénique chimérique masqué spécifique à la protéine tyrosine kinase de type 7 (ptk7) et cellules immunitaires exprimant un tel récepteur
Inventor: SAGERT JASON
IPC: C07K16/28
Filed: 2021-05-06
Abstract: L'invention concerne des constructions de récepteur antigénique chimérique (CAR) masqué comprenant un domaine de liaison à l'antigène extracellulaire spécifique à la protéine tyrosine kinase de type 7 (PTK7), qui est lié à un peptide de masque qui bloque la liaison du CAR masqué à la PTK7. L'invention concerne également des lymphocytes T génétiquement modifiés exprimant un CAR masqué spécifique à la PTK7 et leurs utilisations thérapeutiques.
Patent EP-4146636-A1 (EP)
Inventor: SMITH AUSTIN G
IPC: A61K31/553
Filed: 2021-04-27
Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and R1 are described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
Patent EP-4139726-A1 (EP)
Inventor: HIGLEY JASON
IPC: G02B6/38
Filed: 2021-04-23
Abstract: L'invention concerne un récepteur de ferrule de fibres optiques (200) qui comprend un corps principal (202) qui comporte une ouverture ( 216) s'étendant entre l'extrémité avant (204) et l'extrémité arrière (206) et étant définie au moins par une partie de surfaces internes des quatre côtés. Un premier côté (208) dans l'ouverture présente une première surface conique (208a) et une deuxième surface conique (208b), la première surface conique (208a) réduisant l'ouverture (216) entre l'extrémité arrière (206) et une première position (220) et la deuxième surface conique (208b) augmentant l'ouverture ( 216) entre la première position (220) et l'extrémité avant (204). Il y a également un second côté (210) dans l'ouverture et à travers l'ouverture à partir du premier côté (208), le second côté (210) présente une troisième surface conique (210a) et une quatrième surface conique (210b), la troisième surface conique (210a) réduisant l'ouverture ( 216) entre l'extrémité arrière (206) et une seconde position (222) et la quatrième surface conique (210b) augmentant l'ouverture (216) entre la seconde position (222) et l'extrémité avant (204). Il y a également une première saillie ( 230) s'étendant dans l'ouverture à partir du premier côté (208) pour venir en prise avec une première partie de la ferrule de fibres optiques au niveau de la première position (220), et une seconde saillie (240) s'étendant dans l'ouverture à partir du second côté pour venir en prise avec une seconde partie de la ferrule de fibre optique à la seconde position (222).
Patent EP-4243729-A1 (EP)
Inventor: TABER TODD
IPC: A61F2/16
Filed: 2021-06-01
Abstract: An apparatus for eye surgery may comprise a nozzle having a delivery lumen, an implant bay coupled to the nozzle, an implant disposed in the implant bay, and an actuator coupled to the implant bay. The actuator may comprise a housing, a plunger disposed within the housing, a bore through the plunger, a first coupling proximate to a first end of the plunger, and a second coupling integral to the housing. The bore may be fluidly coupled to the implant bay. The first coupling may be configured to receive a hydraulic driver and fluidly couple a working fluid in the hydraulic driver to the bore. A portion of the plunger may be slidingly disposed through the second coupling. In some embodiments, the second coupling may be configured to retain a drive coupling of the hydraulic driver in a fixed position relative to the housing.
Patent EP-4162619-A1 (EP)
Inventor: KUMAR AKASH
IPC: H04W88/06
Filed: 2021-05-25
Abstract: Divers aspects de la présente divulgation se rapportent, de manière générale, à la communication sans fil. Selon certains aspects, un équipement utilisateur peut déterminer une collision entre une ou plusieurs ressources de signal de référence de sondage (SRS) à utiliser pour une procédure de commutation d'antenne SRS pour une première technologie d'accès radio (RAT) et un signal d'une seconde RAT sur la base, au moins en partie, d'un chevauchement dans le domaine temporel de transmissions d'une ou plusieurs ressources SRS et d'un temps actif du signal de la seconde RAT, et modifier une configuration de la procédure de commutation d'antenne SRS afin d'atténuer la collision, la configuration modifiée indiquant que la ou les ressources SRS sont configurées pour être transmises au moyen d'éléments d'antenne de l'UE qui sont différents des éléments d'antenne de l'UE à utiliser pour recevoir le signal de la seconde RAT. De nombreux autres aspects sont divulgués.
Patent EP-4092150-A1 (EP)
Inventor: FUKUMOTO SHIGEO
IPC: C22C38/28
Filed: 2021-01-08
Abstract: A ferritic stainless steel with chemical composition includes, in mass%, Cr: 10.5 to 25.0%; Al: 0.01 to 0.20%; Ti: 0.15% to 0.35%; O: 0.0001 to 0.0030%; and Mg: 0.008 × [%AI] or more, in which oxysulfide-containing inclusions are present in the steel, a number ratio of the oxysulfide-containing inclusions whose minor axis is 3 µm or more is 5 pieces/mm<sup>2</sup> or less, and a number ratio of the oxysulfide-containing inclusions whose minor axis is 15 µm or more is 0.05 pieces/mm<sup>2</sup> or less. 75% or more of the inclusions whose minor axis is 3 µm or more have an oxysulfide part whose composition satisfies formulae (1) and (2),        CaO + Al<sub>2</sub>O<sub>3</sub> + MgO ≥ 90% ···     formula (1),        Al<sub>2</sub>O<sub>3</sub>/MgO ≤ 1.25 ···     formula (2).
Patent EP-4094934-A1 (EP)
Inventor: OSHIMA NONOKA
IPC: B32B33/00
Filed: 2021-01-05
Abstract: To obtain a decorative sheet having excellent fingerprint resistance of the decorative sheet surface, a decorative plate, and a method for producing a decorative sheet. A decorative sheet includes: a primary film layer; a colored pattern layer provided on one surface of the primary film layer; and a first surface protective layer provided on the surface on the side opposite to the primary film layer of the colored pattern layer, having a core part and ridge-like parts provided to project in a ridge-like shape from one surface of the core part, and having an irregular shape formed on the surface. The first surface protective layer of the decorative sheet is formed by irradiating a surface of an applied ionizing radiation curable resin with a first ionizing radiation having energy capable of cleaving a polymer chain of the ionizing radiation curable resin, to shrink the surface of the ionizing radiation curable resin, and form an irregular shape on the surface of the ionizing radiation curable resin, and irradiating the shrunk ionizing radiation curable resin with a second ionizing radiation curing the ionizing radiation curable resin to cure the ionizing radiation curable resin.
Patent EP-4200534-A1 (EP)
Inventor: WÄCHTLER STEFAN
IPC: F16C33/58
Filed: 2021-07-15
Abstract: Die Erfindung betrifft eine innenringbefestigte Rollenhülse (1), umfassend einen auf einer Welle oder Achse befestigten Innenring (2) und einen auf diesem Innenring (2) angeordneten Rollenkranz (3), der durch einen aus zwei Seitenringen (5, 6) und mehreren Verbindungsstegen (7) bestehenden Lagerkäfig (4) sowie aus einer Vielzahl in diesen Lagerkäfig (4) eingesetzter Rollenwälzkörper (8) gebildet wird, die von dem Lagerkäfig (4) in Umfangsrichtung in gleichmäßigen Abständen gehalten werden und auf einer durch die Außenmantelfläche des Innenrings (2) gebildeten Innenlaufbahn (9) abrollen, wobei die axiale Führung des Rollenkranzes (3) durch zwei an den Axialseiten des Innenrings (2) angeordnete und sich radial nach außen erstreckende Borde (10, 11) erfolgt. Erfindungsgemäß ist durch Ausbildung des Innenrings (2) mit einem Bord (11), der einen größeren Außendurchmesser als der andere Bord (10) am Innenring (2) aufweist, sowie durch Ausbildung dieses Bordes (11) mit einem zu den Rol¬ lenwälzkörpern (8) axial abgebogenen Randbereich (12) der Innenring (2) als fertig geformtes und wärmebehandeltes Bauteil herstellbar sowie als Lagerkäfig (4) ein axial geschlitzter Kunststoffkäfig einsetzbar, dessen einer Seitenring (6) von dem axial abgebogenen Randbereich (12) des Bordes (11) mit dem größe¬ ren Außendurchmesser radial umschlossen wird und den Rollenkranz (3) somit im Innenring (2) fixiert.
Patent EP-4185560-A1 (EP)
Inventor: CAMPOSILVAN ERIK
IPC: A61C13/083
Filed: 2021-07-23
Abstract: La présente invention concerne un corps cru, un corps précéramique et un corps céramique à base de particules d'oxyde métallique, notamment l'oxyde de zirconium. La présente invention concerne également le procédé de fabrication de ces matériaux et leur utilisation, notamment dans le domaine dentaire.
Patent EP-4104436-A1 (EP)
Inventor: XU YAN
IPC: H04N19/172
Filed: 2021-02-11
Abstract: Systems and methods for regulating the speed of movement of virtual objects presented by a wearable system are described. The wearable system may present three-dimensional (3D) virtual content that moves, e.g., laterally across the user's field of view and/or in perceived depth from the user. The speed of the movement may follow the profile of an S-curve, with a gradual increase to a maximum speed, and a subsequent gradual decrease in speed until an end point of the movement is reached. The decrease in speed may be more gradual than the increase in speed. This speed curve may be utilized in the movement of virtual objections for eye-tracking calibration. The wearable system may track the position of a virtual object (an eye-tracking target) which moves with a speed following the S-curve. This speed curve allows for rapid movement of the eye-tracking target, while providing a comfortable viewing experience and high accuracy in determining the initial and final positions of the eye as it tracks the target.
Patent EP-4098334-A1 (EP)
Inventor: KIMIZUKA WATARU
IPC: A63B102/04
Filed: 2021-01-19
Abstract: A badminton racket 2 includes a shaft 4, a frame 6, a grip 8, and a string 10. A flexural rigidity value EI(2) of the shaft 4 at a second measurement point located at a distance of 95 mm from the grip 8 is smaller than a flexural rigidity value EI(1) of the shaft 4 at a first measurement point located at a distance of 35 mm from the grip 8. A flexural rigidity value EI(3) of the shaft 4 at a third measurement point located at a distance of 155 mm from the grip 8 is smaller than the flexural rigidity value EI(2).
Patent EP-4196103-A1 (EP)
Inventor: GOC ANNA
IPC: A61K31/12
Filed: 2021-08-13
Abstract: The way the SARS-CoV-2 virus infects the cell is a complex process and comprises four main stages: attachment to the cognate receptor, cellular entry, replication and cellular egress. Targeting binding of the virus to the host receptor in order to prevent its entry has been of particular interest. We tested 56 polyphenols, including plant extracts, brazilin, theaflavin-3,3'- digallate, and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry of pseudo-typed SARS-CoV-2 virions. Both,theaflavin-3,3'-digallate at 25 μg/ml and curcumin above 10 μg/ml concentration, showed binding with the angiotensin- converting enzyme 2 receptor reducing at the same time its activity in both cell-free and cell- based assays. Our study also demonstrates that brazilin and theaflavin-3, 3'-digallate, curcumin, decrease the activity of transmembrane serine protease 2 both in cell-free and cell-based assays and moderately increased endosomal/lysosomal pH.
Patent EP-4295425-A1 (EP)
Inventor: VOORMANN HAUKE
IPC: H01M8/0202
Filed: 2021-08-03
Abstract: Es wird ein Verfahren zum Fertigen einer graphitischen Bipolarplatte (1) für eine Brennstoffzelle (21) oder eine Flussbatterie beschrieben. Ein Paar von graphitischen Monopolarplatten (3) wird bereitgestellt. Die Monopolarplatten (3) werden entlang einander gegenüberliegender Kontaktflächen (7) der Monopolarplatten (3) miteinander verklebt. Zum Verkleben wird ein 1K-Epoxidharz (9) eingesetzt. Eigenschaften des 1K- Epoxidharzes (9) und/oder Prozessparameter können speziell für den Einsatzfall angepasst sein.
Patent EP-4193529-A1 (EP)
Inventor: ALFARHAN FARIS
IPC: H04L1/18
Filed: 2021-08-03
Abstract: A device (e.g., a wireless transmit/receive unit (WTRU)) may determine which information (e.g., among multiple transport blocks (TBs)) to be sent on resource(s) of a physical uplink channel (PUCCH) transmission occasion of a configured grant (CG). In an example, the device may receive configuration information. The configuration information may indicate a resource associated with the CG. The device may determine whether to transmit (e.g., on the resource associated with CG) first information of a first TB or second information of a second TB based on one or more of downlink feedback information (DPI) reception, a reason why information of a TB (e.g., the first TB or the second TB) has not been sent in a prior transmission, and a nature of the content (e.g., control information vs. data) in the TB. The first TB may comprise the first information and the second TB may comprise the second information.
Patent EP-4179715-A1 (EP)
Inventor: ASAWA MANJARI
IPC: H04W16/22
Filed: 2021-08-10
Abstract: Systems, methods, and non-transitory, machine-readable media for zero-touch interworking of network control with data platform and analytics in virtualized deployment are disclosed. Responsive to a network service request for service location identifiers, data from data sources may be processed, and indicia of data characteristics may be analyzed to create or develop a data model. Configuration specifications may be created to instantiate a network slice and network services as a function of the data characteristics, conforming to quality of service parameters and service location identifiers. A log mapped to the request may be created and included in a template specifying a data observability framework and resources for the network slice and network services. The slice and services may be instantiated with the configuration specifications, with data services provided to user equipment of the external entity, and with the cellular network consequently providing data services to user equipment.
Patent EP-4149429-A1 (EP)
Inventor: MERKUS FRANCISCUS
IPC: A61K31/00
Filed: 2021-08-27
Abstract: The invention relates to a pharmaceutical formulation, in a composition and form suitable for intranasal administration as a spray or drops or gel, containing hydroxocobalamin and/or hydroxocobalamin salts dissolved in water, containing mannitol as main excipient and optionally some other excipients.
Patent EP-4121461-A1 (EP)
Inventor: ZHU YI
IPC: C07K16/30
Filed: 2021-03-17
Abstract: A multi-specific antibody-like protein having a first monomer comprising a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, a second monomer comprising a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the first binding monomer and a second binding monomer are configured to form a dimer, wherein the first monomer and the second monomer are covalently paired through at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, wherein the first monomer and second monomer may comprise optionally a first binding domain (D1) and a second binding domain (D2), and a fourth binding domain (D4) and a fifth binding domain (D5), and wherein the multi-specific antibody-like protein is at least bi-specific.
Patent EP-4124160-A1 (EP)
Title: Technique for performing multi-link communication in wireless communication system
Inventor: KIM NAMYEONG
IPC: H04W76/19
Filed: 2021-03-16
Abstract: According to various embodiments, a multi-link device (MLD) operating in a plurality of links can receive a PPDU through a first link from among the plurality of links. The PPU can include a first information field related to a second link that is differentiated from the first link. The first information field related to a second link can include a second information field related to a link identifier of a second link and a third information field related to whether all pieces of element information related to a second link is included in the PPDU.
Patent EP-4127221-A1 (EP)
Inventor: CHENCHIK ALEX
IPC: C12Q1/6806
Filed: 2021-03-02
Abstract: Single cell genetic analysis methods are provided. Aspects of the methods include: (a) producing a plurality of partitioned cell/barcoded bead complexes from a cellular sample and a plurality of distinct barcoded beads that include a plurality of barcoded reverse gene-specific primers; (b) hybridizing gene-specific template binding domains of the barcoded reverse gene-specific primers to template nucleic acids of the cells to produce primed template nucleic acids; and (c) subjecting the primed template nucleic acids to primer extension reaction conditions sufficient to produce barcoded nucleic acids, e.g., for subsequent amplification and analysis, such as by Next Generation Sequencing (NGS) protocols. Also provided are compositions that find use in practicing embodiments of the methods.
Patent EP-4211287-A1 (EP)
Inventor: CORBINEAU JULIEN
IPC: C23C14/08
Filed: 2021-09-06
Abstract: L'invention concerne une pièce (1) de véhicule automobile comprenant un corps (10) à base d'un polymère présentant une surface (100), un revêtement (11) d'opacification recouvrant au moins une portion de la surface (100). Le revêtement est formé d'au moins une couche mince à base de fer et comprenant au moins un parmi un oxyde de fer et un nitrure de fer, et présente une épaisseur supérieure ou égale à 100 nm sur au moins 50 % de l'au moins une portion de la surface (100). En outre, le revêtement (11) présente une absorption d'un rayonnement lumineux incident supérieure à 70% du rayonnement lumineux incident. Ainsi, le revêtement permet une opacification fiable et reproductible de la surface (100) de la pièce.
Patent EP-4130439-A1 (EP)
Inventor: Nishii Daisuke
IPC: F01D11/08
Filed: 2021-02-12
Abstract: A secondary flow suppression structure (10) includes: a turbine rotor blade (12) including an outer shroud (14); a turbine stator vane (22) located rearward of the turbine rotor blade (12) and including an outer band (24); a seal surface (32) facing the outer shroud (14) at a radial outside of the outer shroud (14); a fin (16) projecting from the outer shroud (14) toward the seal surface (32); and a cavity (42) formed between the seal surface (32) and the turbine stator vane (22), formed in an annular shape extending in a circumferential direction, and provided with an opening portion (44) opening radially inward on a virtual surface (34) of the seal surface (32) extending rearward. A front end (24a) of the outer band (24) is positioned at the same height as the virtual surface (34) in a radial direction, or positioned radially inward of the virtual surface (34) .
Patent EP-4208534-A1 (EP)
Inventor: GAUTAM MANOJ KUMAR
IPC: C12N5/071
Filed: 2021-09-01
Abstract: The invention relates to compositions comprising a three-dimensional network of a synthetic hydrogel cross-linked with a peptide comprising a metalloproteinase (MMP) cleavable linker characterised in that at least (6) different peptides from an adhesion domain of an Extra Cellular Matrix (ECM) component or from a Cell-Adhesion molecule (CAM) are covalently linked to said hydrogel.
Patent EP-4217958-A1 (EP)
Inventor: ILLGNER KLAUS
IPC: G06T5/00
Filed: 2021-09-22
Abstract: Die Erfindung betrifft ein Verfahren zur Erstellung einer plenoptischen Bildaufzeichnung, bei dem mehrere Abbildungen eines Objektbereichs, die mittels einer optischen Einrichtung gleichzeitig nebeneinander auf einer Empfängerfläche erzeugt und digital gespeichert werden, zu Bildaufnahmen weiterarbeitet werden. Erfindungsgemäß erfolgt bei der Weiterverarbeitung automatisch eine Bildkorrektur, bei der zumindest eine der Bildaufnahmen gegenüber der jeweiligen Abbildung geändert wird. Zweckmäßigerweise wird für jede der Abbildungen eine für die jeweilige Abbildung spezifische Bildkorrektur durchgeführt, wobei sich die jeweiligen spezifischen Bildkorrekturen für die einzelnen Abbildungen vorzugsweise voneinander unterscheiden. In einer Ausgestaltung der Erfindung erfolgt bei der Weiterverarbeitung zumindest einzelner der Abbildungen automatisch eine die Bildaufnahme gegenüber der jeweiligen Abbildung ändernde Bildkorrektur derart, dass die Bildaufnahmen aneinander angeglichen werden. Die Erfindung betrifft ferner ein Computerprogrammprodukt, eine Vorrichtung zur Datenverarbeitung und ein Datenträgersignal.
Patent EP-4225097-A1 (EP)
Inventor: DERR KEVIN R
IPC: A43B11/00
Filed: 2021-10-08
Abstract: An upper for an article of footwear includes a fixed closure disposed on one of a medial side and a lateral side of the upper, a plurality of parallel first strands each extending from a first end attached to the other one of the medial side and the lateral side of the upper to a second end attached the other one of the medial side and the lateral side and including a first intermediate portion formed between the first end and the second end, and a plurality of parallel second strands each extending from a third end attached to the one of the medial side and the lateral side of the upper to a fourth end selectively attachable to the fixed closure. The second strands are looped around the first intermediate portion of respective ones of the first strands.
Patent EP-4173908-A1 (EP)
Inventor: XIAO WEIYUAN
IPC: B61H11/10
Filed: 2021-09-30
Abstract: The present disclosure provides an auxiliary air cylinder inflation system and an air brake system for an express freight train, and relates to the field of air brake systems, aiming to improve the problem that the auxiliary air cylinder inflation is subject to the control air cylinder inflation. The auxiliary air cylinder inflation system comprises a control air cylinder inflation valve, a control air cylinder, an auxiliary air cylinder inflation valve, a first passage and a second passage; the control air cylinder inflation valve is provided with a train pipe air outlet, and the control air cylinder is provided with a first train pipe inflation port, and the auxiliary air cylinder inflation valve is provided with a second train pipe inflation port; and the first passage communicates with the train pipe air outlet and the first train pipe inflation port, and the second passage communicates with the train pipe air outlet and the second train pipe inflation port; and the first passage is connected in parallel with the second passage. The air brake system for an express freight train comprises an auxiliary air cylinder inflation system. The control air cylinder and the auxiliary air cylinder inflation valve can be simultaneously inflated through the first passage and the second passage, the auxiliary air cylinder inflation valve inflates the auxiliary air cylinder, and the auxiliary air cylinder inflation valve and the control air cylinder are separately and independently inflated, which is not restricted by the control air cylinder inflation.
Patent EP-4244504-A1 (EP)
Inventor: DUERRE MARKUS
IPC: F16H57/021
Filed: 2021-11-01
Abstract: The invention relates to a device for supporting an intermediate shaft (48) of a transmission (42), the device (10) comprising: - at least one supporting part (14) for supporting an intermediate shaft (48), which supporting part has a peripheral outer surface (26); - at least one carrier part (12), an inner surface (24) of which extends around the outer surface (26) at a first distance (34) from the supporting part (14); and - at least one shaped part (16) for decoupling the carrier part (12) from the supporting part (14); wherein the shaped part (16) is disposed between the inner surface (24) and the outer surface (26), and wherein the shaped part (16) is frictionally connected to the inner surface (24) and to the outer surface (26). The invention provides a device (10) which can be economically manufactured.