Patent SG-11201805040U-A (SG)
Title: Cell reprogramming
Inventor: JABER FIRAS
IPC: C12N5/071
Filed: 2016-12-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPO I PCT (10) International Publication Number WO 2017/106932 Al 1111111111111101110101011111010111110 010110111111111110111011111111111110111111 (51) International Patent Classification: C42N 5/10 (2006.01) Cl 2N 5/0786 (2010.01) C42N 5/12 (2006.01) C12N 5/0783 (2010.01) C42N 5/071 (2010.01) Cl 2N 5/0789 (2010.01) C42N 5/02 (2006.01) C12N 5/0775 (2010.01) C42N 5/0735 (2010.01) Cl 2N 5/077 (2010.01) (21) International Application Number: PCT/AU2016/051287 (22) International Filing Date: 23 December 2016 (23.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2015905349 23 December 2015 (23.12.2015) AU (71) Applicants: MONASH UNIVERSITY [AU/AU]; Wel- lington Road, Clayton, Victoria 3800 (AU). THE UNI- VERSITY OF BRISTOL [GB/GB]; Senate House, Tyn- dall Avenue, Bristol BS8 1TH (GB). RIKEN [JP/JP]; 2-1, Hirosawa, Wako-shi, Saitama, 351-0198 (JP). CELL MOGRIFY LIMITED [GB/GB]; 11/12 Atlantic Wharf, Cardiff CF10 4AJ (GB). (72) Inventors: FIRAS, Jaber; c/- Wellington Road, Clayton, Victoria 3800 (AU). POLO, Jose; c/- Wellington Road, Clayton, Victoria 3800 (AU). GOUGH, Julian; c/- Senate House, Tyndall Avenue, Bristol BS8 1TH (GB). HAY- ASHIZAKI, Yoshihide; c/- 2-1, Hirosawa, Wako-shi, Saitama, 351-0198 (JP). RACKHAM, Owen; c/- 11/12 Atlantic Wharf, Cardiff CF10 4AJ (GB). (74) Agent: FPA PATENT ATTORNEYS PTY LTD; Level 43, 101 Collins Street, Melbourne, Victoria 3000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.1 7(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 17 / 10693 2 Al (54) Title: CELL REPROGRAMMING (57) : The invention relates to methods and compositions for converting one cell type to another cell type. Specifically, the invention relates to transdifferentiation of a cell to a different cell type. The invention relates to a method for determining the tran- scription factors required for conversion of a source cell to a cell exhibiting at least one characteristic of a target cell type. The inven- tion also relates to method of reprogramming or forward programming a source cell.