Patent DE-102008060708-A1 (DE)
Title: Improving contrast properties of medical polymer substrates in framework of imaging processes using magnetic nanoparticles, noble metal colloids or paramagnetic salts, by introducing magnetic nanoparticles or noble metals on the substrate
Inventor: MUELLER-SCHULTE DETLEF
IPC: C08J7/046
Filed: 2008-12-05
Abstract: The method for improving contrast properties of medical polymer substrates in framework of imaging processes using magnetic nanoparticles, noble metal colloids or paramagnetic salts, comprises introducing magnetic nanoparticles or noble metals in dispersed form of an organic phase on the polymer substrate and forming an adherent layer on the polymer substrate after drying or admixing the magnetic nanoparticles or noble metals in powder form to the initial mass, from which the polymer substrate is produced by extrusion- or spinning process, and grafting functional polymers on the substrate. The method for improving contrast properties of medical polymer substrates in the framework of imaging processes using magnetic nanoparticles, noble metal colloids or paramagnetic salts, comprises introducing magnetic nanoparticles or noble metals in dispersed form of an organic phase on the polymer substrate and forming an adherent layer on the polymer substrate after drying or admixing the magnetic nanoparticles or noble metals in powder form to the initial mass, from which the polymer substrate is produced by extrusion- or spinning process, and grafting the functional polymers on the polymer substrate using ionized radiation to ionically bind or complex the paramagnetic or contrast-reinforced agents. The magnetic nanoparticles are formed from ferro-, ferri- or superparamagnetic substances. The magnetic substances are finely milled using a ball mill. The magnetic nanoparticles are dispersed by adding surface-active substances to an organic solvent as continuous phase. The organic solvent selected as continuous phase has a distribution coefficient of -1 to +7. The surface-active substances are added to the organic solvent with a hydrophilic-lipophilic balance value of 2-19 in a concentration of 0.01-5 wt.%. The magnetic nanoparticles are admixed to the organic phase, so that the magnetic nanoparticles have a weight portion of 5-40 wt.% in the organic phase. The polymer substrate is coated with noble metal colloids. The noble metal colloids are admixed to the organic phase, so that the noble metal colloids are present in a concentration of 0.1-5 wt.%. The magnetic substances are admixed in solid powder form to the polymer substrate before the production, so that the magnetic substances in the fabricated polymer substrate are present in a concentration of 0.5-10 wt.%. The noble metals are admixed in powder form to the polymer substrate before the production, so that the noble metals in the fabricated polymer substrate are present in a concentration of 0.5-5 wt.%. The polymer on the polymer substrate is grafted by adding functional vinyl monomers using ionized radiation, which is UV-radiation, gamma radiation or X-ray radiation or accelerated electrons with a total radiation dose of 1-250 kGy. The grafted polymer substrate is incubated with paramagnetic substances. The magnetic colloids-coated, paramagnetic substances-coated or noble metal-coated polymer substrate is provided with a polymer coating. The polymer solution contains 1-20 wt.% of dissolved polymer related to the solvent. The polymer is selected from groups of materials, which create a contact angle of less than 90[deg] after coating the polymer substrate and during wetting with a water drop. The magnetic colloids or noble metal colloids are introduced by immersing into the respective organic dispersion or spraying the dispersion on the polymer substrate. An independent claim is included for a polymer- and/or plastic substrate coating.