baber/WOPTO huggingface dataset:
Patent AU-2020220038-B2 (AU)
Title: Novel immunotherapy against several tumors, such as lung cancer, including nsclc
Inventor: WEINSCHENK TONI
IPC: C07K7/06
Filed: 2020-08-17
Granted: 2021-11-25
Abstract: The present invention relates to peptides, nucleic acids and cells for use in 
immunotherapeutic methods. In particular, the present invention relates to the 
immunotherapy of cancer. The present invention furthermore relates to tumor-associated 
cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated 
peptides that serve as active pharmaceutical ingredients of vaccine compositions that 
stimulate anti-tumor immune responses. The present invention relates to more than 70 novel 
peptide sequences and their variants derived from HLA class I and HLA class II molecules of 
human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune 
responses.
Patent AU-2020273316-B2 (AU)
Title: Crispr-based genome modification and regulation
Inventor: CHEN FUQIANG
IPC: C12N15/10
Filed: 2020-11-19
Granted: 2023-05-18
Abstract: The present invention provides RNA-guided endonucleases, which are 
engineered for expression in eukaryotic cells or embryos, and methods of using the 
RNA-guided endonuclease for targeted genome modification in in eukaryotic cells or 
embryos. Also provided are fusion proteins, wherein each fusion protein comprises 
a CRISPR/Cas-like protein or fragment thereof and an effector domain. The effector 
domain can be a cleavage domain, an epigenetic modification domain, a 
transcriptional activation domain, or a transcriptional repressor domain. Also 
provided are methods for using the fusion proteins to modify a chromosomal 
sequence or regulate expression of a chromosomal sequence.
Patent AU-2020289839-B2 (AU)
Title: Tissue ligation devices and tensioning devices therefor
Inventor: FUNG GREGORY W
IPC: A61B17/12
Filed: 2020-12-17
Granted: 2022-07-07
Abstract: Described here are closure devices and methods for ligating tissue, such 
as the left atrial appendage, and tensioning devices and mechanism for actuating 
these devices. The tensioning mechanisms and devices may allow a user to apply 
one or more predetermined forces to a suture or other portion of the closure 
devices. The closure devices may comprise a suture loop releasably attached to a 
snare loop assembly, and a tensioning mechanism or device may be configured to 
tighten the suture loop and/or release the suture loop from the snare loop 
assembly
WO 2012/170652 PCT/US2012/041285 
27/36 
3100 
3102 
31 118 
3104 
3106 3118 3112 3114 
FIG. 31A 
3120 
3102 3110 3108 
3124 
3122 3104 
3112 3114 
FIG. 31B
Patent AU-2021206834-B2 (AU)
Title: Systems, catheters, and methods for treating along the central nervous system
Inventor: HEDSTROM BLAKE
IPC: A61M25/00
Filed: 2021-07-21
Granted: 2023-08-31
Abstract: Examiner's Abstract 
A system for ameliorating a symptom of bacterial meningitis in a patient, the system comprising: a 
catheter assembly adapted to be introduced in a cerebrospinal fluid space, wherein the catheter 
assembly includes an inner shaft and an outer shaft, wherein the inner shaft defines an infusion 
lumen therein and defines a plurality of infusion openings therein, wherein an aspiration lumen is 
defined between the inner shaft and the outer shaft, and wherein the outer shaft defines a plurality 
of aspiration openings therein; wherein the inner shaft includes a reinforcing coil and wherein the 
plurality of infusion openings are disposed between windings of the reinforcing coil; a pump 
connectable between the aspiration lumen and the infusion lumen to induce a flow of cerebrospinal 
fluid therebetween; and a filter component connectable between the aspiration lumen and the 
infusion lumen, the filter component configured to remove one or more meningitis causing bacterial 
pathogen from the cerebrospinal fluid, to thereby condition the cerebrospinal fluid.
Patent AU-2021409443-B2 (AU)
Title: Device, system and method for throttling current to peripherals
Inventor: LEE WAI MUN
IPC: G06F1/3287
Filed: 2021-12-07
Granted: 2023-12-14
Abstract: A device, method and system for throttling current and/or power to peripherals is provided. A device comprises peripherals powered by a power source. The device further comprises a throttling circuit configured to: in response to receiving a given interrupt, cause throttling of respective currents to a given subset of the peripherals. The device further comprises a sensing circuit configured to: in response to determining that a sensed current from the power source exceeds a threshold current, provide the given interrupt to the throttling circuit. The device further comprises a primary processor configured to: determine the threshold current based at least on a predetermined maximum current of a presently prioritized peripheral; and provide the threshold current to the sensing circuit. The device further comprises a secondary processor configured to: determine the given subset of the peripherals based on an available current overhead.
Patent JP-4309011-B2 (JP)
IPC: F01L1/34
Filed: 2000-02-28
Granted: 2009-08-05
Abstract: PROBLEM TO BE SOLVED: To provide a variable valve timing device having a tip seal, which has high work efficiency in assembling and is excellent in mass productivity. SOLUTION: A tip seal 20 is an article formed by bending a metal plate. The base thereof is provided with a sliding surface 21, and plate spring parts 22, 23 are integrated with the sliding surface 21. The upper surface of the sliding surface 21 is plated with metal softer than that of the metal for forming the inner peripheral surface of a case and the outer peripheral surface of a rotor.
Patent JP-4465564-B2 (JP)
IPC: G10L15/197
Filed: 2000-02-28
Granted: 2010-05-19
Abstract: A preliminary word-selecting section selects one or more words following words which have been obtained in a word string serving as a candidate for a result of voice recognition; and a matching section calculates acoustic or linguistic scores for the selected words, and forms a word string serving as a candidate for a result of voice recognition according to the scores. A control section generates word-connection relationships between words in the word string serving as a candidate for a result of voice recognition, sends them to a word-connection-information storage section, and stores them in it. A re-evaluation section corrects the word-connection relationships stored in the word-connection-information storage section 16, and the control section determines a word string serving as the result of voice recognition according to the corrected word-connection relationships. <IMAGE>
Patent JP-3754866-B2 (JP)
IPC: H01L23/12
Filed: 2000-03-28
Granted: 2006-03-15
Abstract: PROBLEM TO BE SOLVED: To provide a multilayer circuit board having laminated parallel wiring groups wherein it is connected electrically and efficiently with highly densified semiconductor elements, and the number of its laminated layers is reduced, and further, the crosstalk between line conductors in its signal wiring layout portion positioned in its lowermost layer is reduced. SOLUTION: The multilayer circuit board is the one having a signal wiring developing portion and a parallel wiring portion wherein a semiconductor element D is connected with parallel wiring group of the parallel wiring portion via the signal wiring layout portion. The signal wiring layout portion comprises ground conductor/power-supply conductor layers GL/PL and a line wiring layer CL which are under a mounting region M of the semiconductor element D. The parallel wiring portion in the periphery of the signal wiring developing portion comprises a first wring layer L1 comprising a parallel wring group in a predetermined partition region and a second wiring layer L2 comprising another parallel wiring group present in another predetermined partition region which is orthogonal to the first wiring layer L1.  Further, in this multilayer circuit board, the dielectric constant of a portion (LD) interposed between line conductors C of a line wiring layer CLL positioned in the lowermost layer of this multilayer circuit board is made smaller than the dielectric constant of a portion interposed between the line conductor C and the power supply conductor layer PL just above the same.
Patent JP-4046465-B2 (JP)
IPC: G06T5/20
Filed: 2000-08-31
Granted: 2008-02-13
Abstract: An image processing device includes a filtering unit which filters an input image with variable frequency characteristics, an edge detection unit which detects magnitudes of edges appearing in the input image, and a degree-of-white-background-likeliness detection unit which detects degrees of white-background likeliness in respect of local areas of the input image, wherein the filtering unit changes the variable frequency characteristics in response to the magnitudes of edges and to the degrees of white-background likeliness.
Patent JP-4750939-B2 (JP)
IPC: C07C211/38
Filed: 2000-12-05
Granted: 2011-08-17
Abstract: Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst, wherein the catalytically active mass of the catalyst contains, after its preparation and before the treatment with hydrogen,22 to 45% by weight of oxygen-containing compounds of zirconium, calculated as ZrO2,1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO,5 to 50% by weight of oxygen-containing compounds of nickel, calculated as NiO, where the molar ratio of nickel to copper is greater than 1,5 to 50% by weight of oxygen-containing compounds of cobalt, calculated as CoO,0 to 5% by weight of oxygen-containing compounds of molybdenum, calculated as MoO3, and 0 to 10% by weight of oxygen-containing compounds of aluminum and/or manganese, calculated as Al2O3 or MnO2.
Patent JP-5047415-B2 (JP)
IPC: A61K49/22
Filed: 1998-08-19
Granted: 2012-10-10
Abstract: The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substantially aggregate-free sterile aqueous dispersion of gas-containing vesicles.
Patent JP-3891326-B2 (JP)
IPC: F24D13/02
Filed: 1999-02-10
Granted: 2007-03-14
Abstract: The invention relates to a floor heating device comprising an electric heating cable (5) extending backwards and forwards underneath the floor surface (9) to be heated. Metal panels (1, 1a, 1b, 1c, 1d) of rectangular or square configuration are provided with channels (3, 3a, 3b, 3c) extending in parallel in the direction of deposition of the panels. Each metal panel (1, 1a, 1b, 1c, 1d) is fitted on its reverse side with an insulating panel (2) in a sandwich construction in such a manner that the channels (3, 3a, 3b, 3c) of the metal panel (1, 1a, 1b, 1c, 1d) penetrate into the material of the insulating panel (2). The assembled panels (1, 1a, 1b, 1c, 1d) and panels (2) are deposited on the support (4) of the floor in juxtaposed relationship in the longitudinal and transverse directions in such a manner that each channel (3, 3a, 3b, 3c) of one metal panel (1, 1b, 1c, 1d) continues into another channel (3b, 3c, 3a, respectively) formed in the adjacent metal panels (1b, 1c, and 1a, respectively) at the end edge sides of the first metal panel. The heating cable (5) is arranged inside said channels (3, 3a, 3b, 3c) so as to extend from one metal panel (1a) to the next backwards and forwards across the floor.
Patent JP-4378053-B2 (JP)
IPC: B29C67/00
Filed: 1999-02-17
Granted: 2009-12-02
Abstract: A succession of superposed digitized sections of an object are produced from a three-dimensional representation of the object. A powder or a mixture of powders is spread in the form of a fine layer and heated to a temperature close to solid phase sintering temperature of the powder or the mixture of powders. The layer is brought to the sintering temperature by scanning with a laser beam the layer such that a selected part of the powder, corresponding to one of the digitized sections of the object to be produced, is sintered in solid phase by the additional energy supplied by the laser. Additional layers of the powder or the mixture of powders are spread, heated and scanned with the laser beam until all the digitized superposed sections of the object to be produced are obtained.
Patent JP-3634266-B2 (JP)
IPC: G06V10/56
Filed: 2000-02-03
Granted: 2005-03-30
Abstract: A color image processing method for retrieving a color feature describing color features of an image is provided. The color image processing method includes the steps of: a) obtaining color vectors of an input image; b) classifying the color vectors to obtain dominant colors of the input image and the ratios thereof; and c) representing the dominant colors and the ratios thereof as a color feature descriptor of the input image. The color image processing method is applied to an object-based image processing method, thereby allowing fast search and retrieval of multimedia contents.
Patent JP-4468588-B2 (JP)
IPC: H04R25/00
Filed: 1999-02-05
Granted: 2010-05-26
Abstract: A hearing aid with beam forming properties, having at least two microphone channels (1a, 1b) for at least two microphones (2a, 2b), the microphone channels each comprising an analog to digital converter (3a, 3b) and having at least one programmable or program controlled signal processor (5), as well as a digital to analog converter, and at least one receiver and a battery for power supply. The hearing aid particularly comprises in each microphone channel (1a, 1b) a sigma-delta-type analog to digital converter (3a, 3b) including a digital low pas filter and a decimator 94) for converting a 1 Bit Stream of a high clock frequency into a digital word sequence of a lower clock frequency. At least one of the at least two microphone channels contains a controllable delay device (6) connected to the input side of the respective digital low pass filter and decimator (4) of the channel, the delay device (6) being controllable by the at least one signal processor (5). The delay device is preferably integrated into the sigma-delta-ADC (3).
Patent JP-4365533-B2 (JP)
IPC: A61K31/519
Filed: 2000-02-08
Granted: 2009-11-18
Abstract: Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of alcoholism. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral, transdermal or another route of parenteral administration.
Patent JP-4664505-B2 (JP)
IPC: C07C225/16
Filed: 2000-02-29
Granted: 2011-04-06
Abstract: Methods and compositions are disclosed which utilize metabolites of bubropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. The invention further discloses methods of making optically pure bupropion metabolites.
Patent JP-4721535-B2 (JP)
IPC: B25B23/14
Filed: 2001-02-28
Granted: 2011-07-13
Abstract: An electric rotational tool driving switch system in which a driving control by means of a desired push operating system or lever operating system can be selectively performed in accordance with the content of a work when the electric rotational tool is used, an appropriate tightening work of screws, etc. can be always performed efficiently, and handling can be simplified and safety can be sufficiently improved. The electric rotational tool includes an electric motor, a rotational tool, such as a driver bit, etc., which is connected to the output shaft of this electric motor and which performs work, such as the tightening of screws, etc., a driving switch which initiates the above-described work performed by the rotational tool by driving the electric motor, a torque detection means which detects the load torque generated in the rotational tool when the above-described work is completed, and a torque-set automatic stopping means which stops the driving of the rotational tool when the above-described load torque reaches a preset torque value; wherein a driving switch 30 of a push operating system, which switches the electric motor ON when the rotational tool 14 is caused to contact a work object such as a screw, etc. and displaced by being pressed, and a driving switch 32 of a lever operating system, which switches the electric motor ON when a switch lever 26 installed in the grip portion of the electric rotational tool is displaced by being pressed, are respectively constructed by combining magnets 31a, 33a and magnetic sensors 31b, 33b, and the magnetic sensors are respectively connected to the power circuit of the electric motor 12, so that either one of the above-described operating systems can be selected, and the driving of the electric motor is initiated by switching the power circuit ON through the magnetism sensing action of the magnetic sensor of the selected operating system. <IMAGE>
Patent JP-4398109-B2 (JP)
IPC: F16D65/22
Filed: 2001-04-18
Granted: 2010-01-13
Abstract: PROBLEM TO BE SOLVED: To provide a drum braking device having high durability free from the abrasion of a stationary member for placing a crank mechanism as a shoe expanding device, providing the stable braking performance for a long period, and preventing the generation of abnormal noise. SOLUTION: The crank mechanism 22 for expanding and operating a pair of brake shoes 12, 13 are provided with the relatively rotatable brake lever 24 and strut 23, their sliding contact faces 24f, 23f, are movably mounted on upper faces of mounting bolts 20, 21 for mounting an anchor block 16 as the stationary member, and both of a pivot part and a sliding contact part 23f of the strut 23 are positioned at the brake shoe 13 or 12 side with respect to lines α and β in parallel to the brake shaft through contact points P, R of the brake lever 24 and the strut 23 with which both brake shoes 12, 13 abut and engage, when observed from the pivot axial direction of the brake lever 24 and the strut 23.
Patent JP-4602591-B2 (JP)
IPC: B62D55/12
Filed: 2001-05-02
Granted: 2010-12-22
Abstract: The tumbler (1) has peripheral chain teeth and co-operates with a continuous chain, which has chain links with base plates. Each chain link has two symmetrical spaced guide bars connected by a recessed cam-like element, which meshes with the chain teeth of the tumbler. The sprocket area has at least two peripheral sections (U,U'), which has different reference circle parts that have constant tooth widths (3) that vary between segments (S1-S5). The sum of all the different reference circle parts of each peripheral section divided by the number of teeth of the peripheral section results in a value, which corresponds to the constant reference circle parts. The reference circle parts in each peripheral section decreases or increases between maximum and minimum values with respect to the rotation direction (4) of the tumbler in each peripheral section. The transition between the peripheral sections has the largest difference of the reference circle parts. The smallest minimum value is selected, so that a clearance remains between the cam-like element of the chain and the tooth space that allows for manufacturing tolerances in the tumbler and the chain as well as wear of the chain.
Patent JP-4398112-B2 (JP)
IPC: G02F1/1337
Filed: 2001-05-21
Granted: 2010-01-13
Abstract: PROBLEM TO BE SOLVED: To provide a substrate for a liquid crystal display device which makes it possible to easily and precisely measure the sectional shape of linear projections as a substrate for a liquid crystal display device which has a linear projection for alignment restriction formed on its substrate surface. SOLUTION: This substrate has a glass substrate 2 which holds liquid crystal with negative dielectric constant anisotropy together with an opposite substrate, a display area 4 which is formed on the glass substrate 2 and has a plurality of pixel areas arranged in matrix, and an area 8 for sectional shape measurement which has linear projections formed in the display area 4 to restrict the alignment of the liquid crystal and dummy linear projections arranged outside the display area 4, formed of the same forming material with the linear projections to nearly the same height with the linear projections.
Patent JP-3692314-B2 (JP)
IPC: H05K3/40
Filed: 2001-07-17
Granted: 2005-09-07
Abstract: A wired circuit board having a terminal portion formed as a flying lead that can provide enhanced strength of the conductive pattern, both sides of which are exposed, by simple construction to effectively prevent disconnection of the conductive pattern. The wired circuit board having the terminal portion formed as the flying lead in which the both sides of the conductive pattern are exposed includes, in crossing areas where ends of a cover-side opening and ends of a base-side opening and the conductive pattern are crossed each other, (i) the widened portions formed in the conductive pattern or (ii) cover-side projections and base-side projections formed in the cover layer and the base layer, respectively.
Patent JP-4331907-B2 (JP)
IPC: H04B17/309
Filed: 2000-09-04
Granted: 2009-09-16
Abstract: An apparatus and method are described for producing a test signal with a desired signal-to-noise ratio on a selectable output frequency for measuring a transmission system. A carrier signal, generated from a carrier signal, and a noise signal are remixed with the carrier signal in a bandwidth equal to or smaller than a smallest signal bandwidth of the transmission system. The levels of the carrier signal and the noise signal are adjusted to a predetermined ratio based on a measurement of the remixed carrier signal and the remixed noise signal. The noise signal is attenuated and added to the carrier signal until the desired signal-to-noise ratio is attained.
Patent JP-3807319-B2 (JP)
IPC: F24F13/22
Filed: 2002-02-06
Granted: 2006-08-09
Abstract: In a humidity controller having adsorption elements (81, 82) and a refrigerant circuit, in order to prevent drain water (W) produced in evaporators (103, 104) from rusting the interior of the casing of the controller or from dripping into the room, either the drain water (W) is discharged for evaporation into a second air path on the recovery side during dehumidification operation or humidification operation, or it is discharged for evaporation into a first air path on the adsorption side during humidification operation.
Patent JP-4832701-B2 (JP)
IPC: G10L15/06
Filed: 2002-09-12
Granted: 2011-12-07
Abstract: <P>PROBLEM TO BE SOLVED: To make a player thrilled and excited.  <P>SOLUTION: The game machine comprises a rating part 380 for rating the second form element information according to the frequency of searching the second form element information including the first form element information based on the result of the search executed by a topic searching part 360, an acquisition part 371 for acquiring the code information coincide with the ranking among code information by collating the ranking rated by the rating part 380 and the code information, and a first winning determining part 2300 for determining the winning state according to the winning probability value corresponding to the code information acquired by the acquisition part 371.  <P>COPYRIGHT: (C)2004,JPO