baber/WOPTO huggingface dataset:
Patent WO-2004042039-B1 (WO)
Inventor: DE MAGISTRIS MARIA TERESA
IPC: A61K35/12
Filed: 2003-11-05
Abstract: There is disclosed a method of inducing CTLA-4 up-regulation in a T lymphocyte, comprising contacting a T lymphocyte with a compound selected from the group consisting of cyclic AMP, CAMP inducers, cAMP analogs, phosphodiesterase inhibitors and Ca 2+ inducers. The method may be used to induce CTLA-4 upregulation both in resting and activated T lymphocytes. A T lymphocyte obtainable by the method of the invention is also disclosed.
Patent WO-9922118-B1 (WO)
Inventor: BECK ERNST
IPC: F01C9/00
Filed: 1998-10-28
Abstract: Die Erfindung betrifft eine Fördereinrichtung für ein Medium, insbesondere für ein Gas oder für eine Flüssigkeit, mit einer Kolben-/Zylindereinheit, wobei das Medium mittels einer Kolbenbewegung angesaugt und mittels entgegengesetzter Kolbenbewegung sowie aufgrund der Funktion einer Ventileinrichtung gefördert wird. Es ist vorgesehen, daß die Bewegung des Kolbens mittels eines Lagers (Präzisionslager) geführt ist und daß sich das Lager (Präzisionslager) außerhalb des Zylinders (Zylinderraum, Brennraum) befindet.
Patent ES-2040619-B1 (ES)
Title: Cubierta radial con acero, para neumaticos todo terreno
Inventor: YOSHINO SATOSHI
IPC: B60C9/20
Filed: 1991-07-11
Granted: 1994-05-16
Abstract: CUBIERTA RADIAL CON ACERO, PARA NEUMATICOS TODO TERRENO. LA CUBIERTA COMPRENDE UNA CARCASA CON UNA NAPA QUE CONTIENE CUERDAS DE ACERO Y UN CINTURON COMPUESTO POR LO MENOS POR TRES CAPAS DE CUERDAS DE ACERO. EL CINTURON INCLUYE CAPAS PRINCIPALES, CADA UNA DE LAS CUALES CONTIENE CUERDAS INEXTENSIBLES DE ACERO, Y LAS CUERDAS DE ACERO INCLUIDAS EN POR LO MENOS UNA DE ESTAS CAPAS SATISFACEN LAS CONDICIONES DE QUE SU DIAMETRO ES IGUAL EN ESTA CAPA PERO DIFERENTE DEL DE LAS RESTANTES, DE QUE LA RELACION DEL DIAMETRO DE LAS CUERDAS QUEDA DENTRO DE LA GAMA DE 1,2-3,0, Y DE QUE LA RELACION DE CARGA TOTAL DE ROTURA DE LAS CUERDAS DE ESTAS CAPAS, POR ANCHURA UNITARIA, QUEDA EN LA GAMA DE 1,1-2,0. LA INVENCION SE APLICA PARA AUMENTAR LA RESISTENCIA DE TALES CUBIERTAS, SIN AUMENTOS DE COSTES NI GENERACION DE CALOR.
Patent ES-2072200-B1 (ES)
Title: Equipo universal para la ejecucion de prebovedas y tratamientos complementarios en excavaciones subterraneas.
Inventor: CASAS ORTA PEDRO ANTONIO
IPC: E21D9/00
Filed: 1993-06-21
Granted: 1998-07-16
Abstract: LA INVENCION CONSISTE EN UN EQUIPO UNIVERSAL PARA LA EJECUCION DE PREBOVEDAS Y TRATAMIENTOS COMPLEMENTARIOS EN EXCAVACIONES SUBTERRANEAS, EL CUAL CONSTA DE UNA ESTRUCTURA METALICA CONSTITUIDA POR UN PORTICO DE DOS ARCOS ARRIOSTRADOS EN PARALELO Y SOBRE EL QUE DISCURRE UN CARRO PORTA-MASTIL EL CUAL MONTA UN SUB-MASTIL CON POSIBILIDAD DE ORIENTACION TRIDIMENSIONAL MEDIANTE UN SISTEMA CINEMATICA, CONTANDO CON UNA UNIDAD MOVIL DE TRASLACION EN LA QUE VA INSTALADA LA PLANTA HIDRAULICA.
Patent ES-2084552-B1 (ES)
Title: Maquina para control de estanqueidad de elementos de motores y circuitos estancos de vehiculos.
Inventor: VILLAFRANCA FERNANDEZ UBALDO
IPC: G01M3/26
Filed: 1993-10-22
Granted: 1998-03-01
Abstract: MAQUINA PARA CONTROL DE ESTANQUEIDAD DE ELEMENTOS DE MOTORES Y CIRCUITOS ESTANCOS DE VEHICULOS, FORMADA POR UN BASTIDOR (1) QUE QUEDA DISPUESTO EN MONTAJE GIRATORIO, ENTRE CUYOS LARGUEROS LONGITUDINALES SE INCORPORAN EN UN MONTAJE DESLIZANTE UNOS PUENTES TRANSVERSALES INFERIORES (4) Y OTROS PUENTES SUPERIORES (6), PREVISTOS PARA LA SUJECION ENTRE ELLOS DE LAS PIEZAS A CONTROLAR, MEDIANTE APRIETO CON CORRESPONDIENTES HUSILLOS (9) DE LOS PUENTES SUPERIORES (6); YENDO LA MAQUINA PROVISTA CON UN SISTEMA DE PRESION, RELACIONADO CON UN FUGOMETRO-CAUDALIMETRO DETECTOR (13), PARA MEDIANTE LA CONEXION A LAS PIEZAS EN TRATAMIENTO, DETECTAR LA PRESENCIA DE FUGAS EN LAS MISMAS POR DIFERENCIA DE LA PRESION.
Patent ES-2075803-B1 (ES)
Title: Procedimiento de la deteccion de neumolisina
Inventor: MENDEZ GARCIA FCO JAVIER
IPC: G01N33/577
Filed: 1993-12-17
Granted: 1996-05-16
Abstract: PROCEDIMIENTO DE DETECCION DE NEUMOLISINA. LA DETECCION SE LLEVA A CABO MEDIANTE UN INMUNOENSAYO (TIPO SANDWICH ELISA DIRECTO) EN EL QUE SE EMPLEAN PAREJAS DE ANTICUERPOS MONOCIONALES ESPECIFICOS PARA DISTINTOS EPITOPOS DE LA NEUMOLISINA. UNO DE ELLOS SE EMPLEA COMO ANTICUERPO CAPTURA Y EL OTRO COMO ANTICUERPO DE REVELADO. LA CAPTURA DE NEUMOLISINA EN MUESTRA BIOLOGICAS DE PACIENTES EN DIAGNOSTICA DE LA PRESENCIA DE NEUMOCOCOS COMO AGENTES RESPONSABLES DE LA PATOLOGIA OBSERVADA. SE REIVINDICA COMO DE NUEVA Y PROPIA INVENCION: LA DETECCION DE NEUMOLISINA EN MUESTRAS BIOLOGICAS Y LA APLICABILIDAD DE ANTICUERPOS MONOCIONALES ESPECIFICOS PARA LA NEUMOLISINA EN PROCEDIMIENTOS DE DIAGNOSTICO DE INFECCION NEUMOCOCICAS.
Patent ES-2130019-B1 (ES)
Title: Hoja de envoltura para transporte.
Inventor: AGUT PHILIPPE
IPC: D21H19/22
Filed: 1995-02-10
Granted: 2000-05-01
Abstract: Hoja de envoltura para transporte destinada a la envoltura mecanizada de documentos, clasificada automáticamente y distribuida por vía postal. Según la invención, la hoja de envoltura contiene un soporte de papel opaco, imprimible y autosellable por medio de un adhesivo de sellado en frío y presente al menos parcialmente en la cara interna de dicho soporte.
Patent ES-2130942-B1 (ES)
Title: Equipo para separacion de productos volatiles en plantas de tratamiento de residuos urbanos.
Inventor: GAINZA LAFUENTE EUSEBIO
IPC: B07B9/00
Filed: 1996-06-18
Granted: 2000-02-16
Abstract: Equipo para separación de productos volátiles en plantas de tratamiento de residuos urbanos. Cuenta con una pareja de cintas transportadoras (1) y (5) para movilización de los residuos, situadas a diferente nivel, descargando la primera sobre la segunda a través de una tolva (2) abierta superior e inferiormente, en la que se establece una tubería lateral (6) de impulsión de aire y otra tubería de aspiración (7), contrapuesta a la anterior, situándose en el seno de la tolva (2) una pareja de deflectores de varillas, concretamente un deflector (8) encima de la tubería de impulsión (6) y un deflector (9) debajo de la boca de aspiración (10), de manera que en la caída gravitatoria de la basura desde la cinta transportadora superior (1) a la inferior (5), los productos volátiles son arrastrados lateralmente, hacia la boca de aspiración (10), por la corriente de aire existente en el seno de la tolva (2). Posteriormente estos residuos son triturados y compactados en forma de pacas. Figura 4.
Patent ES-2125802-B1 (ES)
Title: Composicion farmaceutica para la administracion oral de hierro en lechones y procedimiento para su obtencion.
Inventor: BOU I MAS SALVADOR
IPC: A61K33/26
Filed: 1996-07-16
Granted: 1999-11-16
Abstract: Composición farmacéutica para la administración oral de hierro en lechones y procedimiento para su obtención. Comprende (i) excipientes oleosos vehicualizadores entre 50 y 70%, (ii) agentes gelificantes entre 1 y 4%, y (iii) metionato de hierro entre 30 y 80% de manera que la composición presenta entre 50 y 100 mg de Fe/ml y una viscosidad entre 500 y 1.500 cps. Además comprende (iv) conservantes entre 0,2 y 0,6%, y (v) aromas entre 0,3 y 0,50%. El procedimiento comprende: adicionar excipientes oleosos (i) en un reactor adecuado; añadir bajo agitación agentes gelificantes (ii); calentar hasta fusión completa de la masa anterior, agitando lentamente; dejar enfriar hasta la formación de un gel transparente; a temperatura ambiente, adicionar metionato de hierro bajo fuerte agitación hasta homogeneización del producto; pasar por un refinador hasta obtener una textura apropiada. Utilización de la composición por vía oral para prevenir la aparición de la anemia ferropénica.
Patent ES-2145657-B1 (ES)
Title: Sistema de blindaje modular y flexible para aeronaves.
Inventor: ANDRADA GALAN MARIO
IPC: B64D7/00
Filed: 1996-10-01
Granted: 2000-12-16
Abstract: Sistema de blindaje modular y flexible para aeronaves, constituido por un conjunto de paneles balísticas flexibles, formados por un laminado de capas y aramida unidas entre si mediante un guateado y un remallado en todo su perímetro. Los paneles balísticos flexibles de pavimento, se adosan al pavimento-del mismo por su propio peso y por el cierre de forma que realiza contra los zócalos pavimentales, mientras que los paneles de paramento, están armados en su cara posterior por una estructura tubular desmontable de polipropileno, polietileno o PVC, que se fija a la estructura de la aeronave mediante un conjunto de piezas (tipo grapas), sin precisar realizar mecanizados sobre las cuadernas de la aeronave.
Patent ES-2123459-B1 (ES)
Title: Limpiador de cristales para ventanas de corredera y de apertura al exterior.
IPC: A47L1/09
Filed: 1997-04-07
Granted: 1999-09-16
Abstract: LIMPIADOR DE CRISTALES PARA VENTANAS DE CORREDERA Y DE APERTURA AL EXTERIOR. CONSISTE EN UN LIMPIADOR DE CRISTALES FORMADO POR TRES ELEMENTOS: UN MANGO, UN TUBO CON FORMA DE U, QUE PRESENTA LA PARTICULARIDAD DE LIMPIAR LA CARA EXTERNA DEL CRISTAL DESDE LA POSICION INTERIOR AL MISMO, Y UN ELEMENTO LIMPIADOR QUE SE DESLIZA A LO LARGO DEL TUBO PARA ACCEDER A DISTINTAS ZONAS DEL CRISTAL. SE HA PREVISTO UNA VERSION EN LA QUE TANTO EL ELEMENTO DE GIRO SITUADO EN LA PARTE SUPERIOR DEL MANGO COMO EL ELEMENTO LIMPIADOR INTEGREN UN SISTEMA QUE LOS FIJE UNA VEZ DISPUESTOS EN LA POSICION DESEADA.
Patent ES-2137870-B1 (ES)
Title: Composicion para la impermeabilizacion y/o insonorizacion de superficies y procedimiento para la aplicacion de dicha composicion.
Inventor: MUNTAL TRAVERIA JOAN
IPC: C08L95/00
Filed: 1997-10-24
Granted: 2000-08-16
Abstract: Composición para la impermeabilización y/o insonorización de superficies y procedimiento para la aplicación de dicha composición. La composición comprende una emulsión impermeabilizante aniónica y una emulsión impermeabilizante catiónica. El procedimiento consiste en aplicar simultáneamente sobre la superficie a impermeabilizar y/o insonorizar una emulsión impermeabilizante aniónica y una emulsión impermeabilizante catiónica. Al mezclarse una emulsión aniónica y otra catiónica, la mezcla coagula sin necesidad de ruptor o coagulante y reduciéndose la cantidad de agua sobrante.
Patent ES-2149728-B1 (ES)
Title: Dispositivo para la deteccion de la posicion de un piston neumatico.
Inventor: VAZQUEZ VILLALABEITIA MANUEL
IPC: F15B15/28
Filed: 1999-03-18
Granted: 2001-06-01
Abstract: Dispositivo para la detección de la posición de un pistón neumático. En la presente memoria se describe una invención para la detección de la posición de un pistón neumático móvil al que se ha adosado un imán potente en un extremo. El dispositivo es capaz de distinguir sin ambigüedades la presencia del pistón en las posiciones finales de su de recorrido. El dispositivo está basado en el uso hilos amorfos ferromagnéticos que varían su impedancia cuando se encuentran bajo la acción de un campo magnético. Dos elementos sensores son colocados en los brazos de un puente de Wheatstone. La posición de pistón neumático se realiza mediante la comparación de la fase relativa entre la señal de alimentación y la señal en el puente.
Patent FR-2803242-B1 (FR)
Inventor: SAURON JEAN
IPC: B29C65/00
Filed: 2000-01-04
Granted: 2002-08-23
Abstract: Pipe welder consists of supports (13, 15), to hold pipes end-to-end and coaxial with one another, a system for moving the pipes axially towards and away from one another, and a mobile heating plate (5) on a frame (39). The coupling between the heating plate and the frame is offset from the pipes' axis, and it is suspended from a horizontal bar on a portal frame and moved by an arm (41). Pipe welder consists of supports (13, 15) to hold the two pipes end-to-end and coaxially with one another, a system for moving the pipes axially towards and away from one another, and a mobile heating plate (5) on a frame (39). The plate can be moved between two positions one between the ends of the two pipes and another away from them; it has two opposite heating surfaces facing the ends of the two pipes to be joined, and is mounted on the frame so it can rotate about two axes (33) which lie transversely to the axis of the pipes and are not parallel to one another. The coupling between the heating plate and the frame is offset from the pipes' axis, and it is suspended from a horizontal bar on a portal frame and moved by an arm (41). One of the heating plate's axes of rotation is vertical and designed to compensate for an angled end on one or both pipes; the other is horizontal and allows the plate to tilt about a horizontal axis when moved by the pressure of one or both pipes.
Patent FR-2810159-B1 (FR)
Inventor: SEMOND FABRICE
IPC: H01L21/20
Filed: 2000-06-09
Granted: 2005-04-08
Abstract: The invention concerns a monocrystalline coating crack-free coating of gallium nitride or mixed gallium nitride and another metal, on a substrate likely to cause extensive stresses in the coating, said substrate being coated with a buffer layer, wherein: at least a monocrystalline layer of a material having a thickness ranging between 100 and 300 nm, preferably between 200 and 250 nm, and whereof crystal lattice parameter is less than the crystal lattice parameter of the gallium nitride or of the mixed gallium nitride with another metal, is inserted in the coating of gallium nitride or mixed gallium nitride with another metal. The invention also concerns the method for preparing said coating. The invention further concerns electronic and optoelectronic devices comprising said coating.
Patent FR-2815298-B1 (FR)
Inventor: DAUVERGNE JEAN
IPC: B60R13/02
Filed: 2000-10-17
Granted: 2003-05-30
Abstract: A door for a vehicle, in particular a motor vehicle, having a face designed to be orientated towards the interior of the vehicle or interior face, and a face designed to be orientated towards the exterior of the vehicle, or exterior face. The door permitting the installation of one or more fittings at least partially located, in particular, between the interior and exterior faces. The door is constituted by a reinforcement, capable of supporting the fitting or fittings, and by means for cladding the reinforcement, defining with the reinforcement, on either side thereof, interior and exterior compartments enabling the fitting or fittings to be accommodated.</PTEXT>
Patent FR-2821855-B1 (FR)
IPC: C12N15/70
Filed: 2001-03-09
Granted: 2004-04-02
Abstract: The invention relates to a new series of bacterial plasmid vectors which are fully devoid of CpG and which can express synthetic genes which do not contain CpG in the bacteria Escherichia coli.
Patent FR-2826716-B1 (FR)
Inventor: GAMBY BRUNO
IPC: F42C15/40
Filed: 2001-06-29
Granted: 2003-10-03
Abstract: The pyrotechnic initiation circuit (IP) contains a reservoir of electrical energy (AI) connected to the positive poles (PP) of an igniter (FL) via two switches (I1,I3) in series. The negative poles are connected to a third switch (I2). The first verification circuit (V1) is connected to the first switch via a cutout circuit (FU). The second verification circuit (V2) is connected to the third switch and the analyzing and sequencing circuits are connected to the second switch and the cutout circuit. There are connections to circuits on board the aircraft carrying the missile (C1-C3).
Patent FR-2837809-B1 (FR)
Inventor: BRAUD MARCEL CLAUDE
IPC: B66F9/065
Filed: 2002-03-29
Granted: 2004-11-12
Abstract: The elevator truck has two forward wheels (2) and one rear wheel (1) which is steerable from the driving seat (5) and also driven by an engine with hydrostatic transmission. An extending and lifting arm (7) is hydraulically driven and has a good range of action. Shoes (11) on either side of the rear wheel assist stability which is further improved by automatic speed limitation when turning
Patent FR-2838398-B1 (FR)
Inventor: SCHWAB JEAN
IPC: B60P1/64
Filed: 2002-04-11
Granted: 2004-12-24
Abstract: The trailer (3) load bearing structure (30) comprises a chassis (7) with wheels and hitching means (6) and a platform (8) for the load (4) coupled the chassis. The platform comprises auxiliary wheels (9) so as to be able to be displaced relative to the chassis. The chassis has a central rail (77) able to receive a complementary guard rail (83) on the platform so as to create a linking connection between the platform and the chassis.
Patent FR-2849763-B1 (FR)
Inventor: LEVEQUE JEAN LUC
IPC: A61B5/103
Filed: 2003-01-14
Granted: 2012-10-26
Abstract: The apparatus to measure the hydration of skin or mucous membranes, at a selected zone, has a sensor (10) with a network of non-optical detection cells and preferably capacitative cells with a spatial resolution of at least 100 micron in at least one direction. An image (60) is derived from the sensor signals at a micro-computer (20) through an interface (30).  The micro-computer is linked to a remote server (40) through an Internet or intranet communication network (41).
Patent FR-2853601-B1 (FR)
Inventor: QUEVEAU GERARD
IPC: B60R5/04
Filed: 2003-04-10
Granted: 2006-03-17
Abstract: The system has a support (8) attached to a backrest (3) of a seat, and a flap (9) moving with respect to the support between arranged and exit positions. The flap moves between its arranged position and deployed position in which it covers a luggage arranging space situated between a front edge (7) of a rear trunks bonnet (5) and the backrest that is in a forward tilted position. The space between the backrest and the front edge of the bonnet is freed in the arranged position and is covered in the exit position.
Patent FR-2862641-B1 (FR)
Inventor: RICHARD HERVE
IPC: C08L83/08
Filed: 2003-11-25
Granted: 2006-03-03
Abstract: New diorganosiloxane compounds (1) and (2) with a 4,4-diarylbutadiene group singly or as a mixture and a composition comprising them. The diorganosiloxanes are of Formula (1) or Formula (2). [Image] A : a residue of formula (3); R 1OH, 1-10C alkyl or alkoxy; R 1+R 11-3C alkylene dioxy cycle; R 2, R 3, R 41-10C alkyl optionally comprising one or more halogen, phenyl; p : 0,1; A : H, 1-8C alkyl, phenyl, Si(CH 3) 3; n : 0, 2; Z 1H, -(C=O)OR 2, -(C=O)R 3, -(C=O)NR 4R 5, - SO 2R 6, -CN, -(C=O)-X-L; R 5H, 1-20C alkyl; R 61-20C optionally cyclic alkyl, 6- 12C aryl; R 7, R 8H, 1-20 C alkyl; X : -O-, -NR 4-; L : -CH 2-C(Y 1)-(W 1) p-, CH=CH-(W 1) p-, C(=CH 2)-(W 1) p-; W 11-6C alkylene optionally substituted with OH or 1-8C alkyl; Y 1H, 1-8C alkyl; p : 0,1; R : 1-20C alkyl, phenyl, trifluoro-3,3,3-propyl, trimethylsilyloxy; B 1R, A; r : 0-50; s : 0-20; u : 1-6; t : 0-10; t+u : 3 or more; R 2H, 1-20C alkyl; R 3, R 61-20C alkyl, 6-12C aryl; and R 4, R 5H, 1-20C alkyl. [Image] Provided that if s is 0 then at least one of B is A. If 2 (C+O)-X-L are present L is only linked to one group A or B. Independent claims are included for the use of the claimed compounds (1) as agents to control variations in skin color caused by UV radiation of wavelength 320-400 nm; (2) as photostabilizers for polymers or glasses.
Patent FR-2890162-B1 (FR)
Inventor: COTTARD BERNARD
IPC: F28F13/12
Filed: 2005-08-30
Granted: 2007-11-30
Abstract: The device has a mobile rotary element (3) and a fixed bearing-forming element (2) solidly connected to an upstream end of a tube (1). The mobile element comprises an upstream trunnion-forming part (4) and a downstream turbulence-generating part (5) which is rotated by the flow of the fluid in the tube. The upstream and downstream parts are connected with respect to each other using a flexible connector (6) deformable along entire length. The connector is made of stainless steel, plastic, carbon fiber, synthetic fiber or elastomer.
Patent FR-2895597-B1 (FR)
Inventor: HOBRAICHE JULIEN
IPC: H02M1/08
Filed: 2005-12-22
Granted: 2008-09-05
Abstract: The method involves applying a switching function production process, in order to produce a reduced number of switching function combinations corresponding to free wheel control vectors for producing a sequence of control vectors. The switching function production process comprises the determination of modulants associated with corresponding bridge arms (B1-B3) of a power bridge e.g. tri-phase inverter from scalar voltage set points. Independent claims are also included for the following: (1) a device for piloting a power bridge (2) an electrical rotating machine.
Patent FR-2899737-B1 (FR)
Inventor: RIPOLL CHRISTOPHE
IPC: F02D41/30
Filed: 2006-04-10
Granted: 2008-12-05
Abstract: A device for driving ultrasound piezoelectric actuators, on the basis of a DC voltage. The device includes an impedance matching branch mounted in parallel with the actuators and including a capacitor in series with a selection switch, which is closed and opened, at the same time as the selection switch of the actuator to be excited, so that the voltage across the terminals of the matching capacitor and the voltage across the terminals of the selected actuator are almost zero before the start and after the end of the injection. A method of controlling the matching switch makes it possible to benefit from the capacitive charge during the pulse train causing the injection, while circumventing abrupt discharges at the start of the train. Such a device and method may find application to the engines of motor vehicles, as one example.
Patent FR-2909951-B1 (FR)
Inventor: GIACOMIN FABRICE
IPC: B60R25/021
Filed: 2006-12-19
Granted: 2009-03-20
Abstract: The invention relates to an anti-theft device for the steering column of a motor vehicle, comprising a locking device including: a sensor (4) located close to the input of the rotor (2) such that it can be biased by the key (3) once it has been introduced into the rotor (2), and a retractable retaining member which can move between a locked position in which it acts on the control finger (7) in order to prevent the longitudinal movement of the slide (6) in the direction of the cam (8) counter to elastic means and an unlocked position in which the slide is released and can move under the action of the elastic means. In addition, coupling means between the sensor (4) and the retaining member enable said retaining member to be moved into: the locked position when the rotor (2) is in the rest position and the key (3) is engaged therein, and the unlocked position when the rotor (2) is in the rest position and the key is removed therefrom.
Patent FR-2900334-B1 (FR)
Inventor: DALKO MARIA
IPC: A61K8/49
Filed: 2006-04-28
Granted: 2008-06-27
Abstract: De pigmenting and/or whitening human skin involves applying a composition (C1) containing at least one nosiness compound of formula (I) and its salt, optical isomer or solvating in a physiological medium to human skin. De pigmenting and/or whitening human skin involves applying a composition (C1) containing at least one nosiness compound of formula (I) and its salt, optical isomer or solvating in a physiological medium to human skin. R 1 and R 2saturated, linear 1-6C hydrocarbon, unsaturated, linear 2-6C hydrocarbon or optionally saturated, branched 3-6C hydrocarbon; R 1+R 2+O : polypropylene radical; R 3saturated, unsaturated or branched 3-10C hydrocarbon (optionally substituted by at least one -OR', -NR'R'', -COOR', -CONR'R'', -CF 3, -F, -OCF 3, -CN or -NO 2), saturated or linear 1-10C hydrocarbon, unsaturated or linear 2-10C hydrocarbon, -COR 4 or ester group resulting from biotin; R 4optionally saturated or branched 3-9C hydrocarbon (optionally substituted by -OR', -NR'R'', -COOR', -CONR'R'', -CF 3, F, -OCF 3, CN or -NO 2), saturated or linear 1-9C hydrocarbon, or unsaturated or linear 2-9C hydrocarbon; R' and R'' : optionally saturated or branched 3-6C hydrocarbon radical (optionally substituted by -OZ 1, -NZ 1Z 2 or -COOZ 1), saturated or linear 1-6C hydrocarbon, or unsaturated or linear 2-6C hydrocarbon; Z 1 and Z 2saturated or linear 1-6C hydrocarbon, unsaturated or linear 2-6C hydrocarbon, optionally saturated or branched 3-6C hydrocarbon radical, or H. [Image] ACTIVITY : None given. MECHANISM OF ACTION : Parthenogenesis inhibitor. The efficacy of 2',3'-polypropylene-5'-butanoyladenosine (Ia) was evaluated for melanogenesis inhibitory activity using a method as described in R. Schmidt, P. Brien and M. Grenier, Anal. Biochemist., 235(2),113-18, 1996 and IC 5 0 value was measured. (Ia) Showed an IC 5 0 value of 7.4 mu m.