baber/WOPTO huggingface dataset:
Patent IE-902389-L (IE)
Title: Enzymatically binding bioactive materials to proteins
IPC: C07K16/00
Filed: 1990-06-29
Abstract: The invention provides a means for attaching a label, support or bioactive agent to the protein at a site that is remote from the active site of the protein. More specifically the invention is directed to a method for the attachment of an amino acid, amino acid derivative, amine and alcohol nucleophile to the carboxyl terminus of a protein. In one embodiment, an exopeptidase enzyme is utilized to attach a labeled nucleophile to a protein such as an antibody. In other embodiments, the invention is directed to a method for the attachment of a protein to an immobilization support and to a method for the attachment of a bioactive agent to a protein.
The invention provides a means for attaching a label, support or bioactive agent to a protein with an exopeptidase at a site that is remote from the active site of the protein. More specifically the invention is directed to a method for the attachment of an amino acid, amine and alcohol nucleophile to the carboxyl terminus of a protein. In one embodiment, a labeled nucleophile is attached to a protein such as an antibody. In other embodiments, the invention is directed to a method for the attachment of a protein to an immobilization support and to a method for the attachment of a bioactive agent to a protein.
[US5279954A]
Patent IE-882600-L (IE)
Title: Isoxazole-ß-carboline derivatives
IPC: C07D471/04
Filed: 1988-08-26
Abstract: beta -Carbolines are described of the formula I <IMAGE> in which Y represents the radical <IMAGE> and R<a> and R<b> are identical or different and each represents hydrogen, C1-6-alkoxy, phenyl, C3-7-cycloalkyl, substituted or unsubstituted C1-6-alkyl or C1-6-alkoxycarbonyl and R<c> and R<d> are identical or different and each denote hydrogen or C1-6-alkyl or together denote a bond and R<4> is hydrogen, C1-6-alkyl or C1-6-alkoxy-C1-6-alkyl and R<5> is hydrogen, halogen, OR<6>, NR<7>R<8> or CHR<9>R<1><0>, where R<6> denotes C1-6-alkyl, C3-7-cycloalkyl or a substituted or unsubstituted aralkyl, aryl or hetaryl radical, R<7> and R<8> are identical or different and represent hydrogen, C1-6-alkyl, C3-6-alkenyl or together with the nitrogen atom represent a saturated heterocyclic 5- or 6-membered ring which may contain a further hetero atom, where R<9> denotes hydrogen or C1-6-alkyl, R<1><0> denotes hydrogen, C1-6-alkyl, OR<1><1> or NR<1><2>R<1><3>, where R<1><1> is C1-6-alkyl, and R<1><2> and R<1><3> are identical or different and simply represent hydrogen or C1-6-alkyl or jointly, together with the nitrogen atom, represent a saturated heterocyclic five- or six-membered ring which may contain a further hetero atom. 
[EP0305322A2]
Patent IE-772666-L (IE)
Title: Pharmaceutical composition
IPC: C07J17/00
Filed: 1977-12-30
Abstract: Sterol glycosides and esters thereof with monocarboxylic acids of natural or synthetic origin are used to combat human and animal illness in dosages of not over 10 mg per day.
[US4188379A]
Patent IE-813077-L (IE)
Title: 2-keto-steroids
IPC: C07J41/00
Filed: 1981-12-23
Abstract: Novel steroids of the formula    <IMAGE>  I'  wherein R is selected from the group consisting of R1 and R2, R1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R2 is -(CH2)n-R3, n is an integer from 1 to 8 and R3 is selected from the group consisting of free or protected -OH, free or protected -NH2, monoalkyl and dialkylamino with 1 to 6 carbon atoms, a free, esterified or salified -COOH and halogen X and Y together form   <IMAGE>  or X is OH and Y is -CH2-CH2-COOM, M is selected from the group consisting of hydrogen, an alkali metal and -NH4, Ra is selected from the group consisting of hydrogen and methyl, the dotted line in the I(2)-position indicates the optional presence of a double bond and the wavy line indicates that R may be in the  alpha - or  beta -position, with the proviso that R is not R1 or R2 when n is 1 and R3 is halogen, when the 1(2) bond is a simple bond and when Ra is -CH3, R3 is not a free carboxyl when Y is -CH2-CH2-COOM in which M is an alkali metal or -NH4 and R3  is not a salified carboxyl when Y is -CH2-CH2-COOH having aldosterone antagonistic properties and increases aqueous sodium diuresis while conserving organic potassium without secondary hormonal effects and their preparation.
Patent IE-883573-L (IE)
Title: 2-(piperazinyl)-2-oxoethylene flavenoids
IPC: C07H17/07
Filed: 1988-11-30
Abstract: Compound of general formula I:   <IMAGE> (I)  in which: A is a single or double bond, R1 and R3, which may be identical or different, are each a hydrogen atom, an alkoxycarbonylmethylene radical of formula -CH2CO2R4 (in which R4 denotes an alkyl radical having 1 to 5 carbon atoms) or a radical of formula W:  <IMAGE>  (in which n is equal to 0 or 1 and R5, R6 and R7, which may be identical or different, are each a hydrogen or halogen atom, a hydroxyl radical, a trifluoromethyl radical, a lower alkyl radical containing 1 to 5 carbon atoms or an alkoxy radical containing 1 to 5 carbon atoms), R2 is a hydrogen atom, an alkoxycarbonylmethylene radical of formula -CH2CO2R4, a radical of formula W, or a  beta -glucose or rutinose molecule linked to the oxygen to which it is attached with a glycoside bond, on condition, however, that at least either R1 or R2 or R3 always denotes a radical of formula W, and their addition salts with a pharmaceutically acceptable inorganic or organic acid.
Patent IE-950248-L (IE)
Title: Piperazine derivatives
IPC: C07D221/20
Filed: 1990-04-20
Abstract: Piperazine derivatives of formula <CHEM> and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R<1> is an aryl or nitrogen containing heteroaryl radical, R<2> is hydrogen or lower alkyl, R<3> is aryl, C4-8 alkyl or aryl(lower)alkyl and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT1A antagonists and can be used, into alia, for the treatment of CNS disorders, such as anxiety.
Patent NO-792283-L (NO)
Inventor: HORN ALBERT R VAN
IPC: C07C401/00
Filed: 1979-07-09
Abstract: Novel 16-phenoxy and 16-(o, m or p)-substituted phenoxy derivatives of (dl)-9-keto-11 alpha ,15 alpha -dihydroxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acid, the pharmaceutically acceptable, non-toxic lower alkyl esters and salts thereof and processes for the production of such compounds. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as inhibitors of gastric acid secretion; and as agents for the control of asthmatic attack, because of their bronchodilating activity.
Patent NO-800721-L (NO)
Inventor: PERCIWALL EVERT WILFORD
IPC: C09J5/00
Filed: 1980-03-13
Abstract: A process and a device for gluing materials with curable aminoplastic adhesives with separate application to the joint of a resin component of the adhesive and a hardener component containing an acid or an acid-forming substance. The application is simplified and the separate application on one and the same joint surface of both components is made possible by first applying the hardener component in the form of an aqueous solution to the joint surface by means of a roll which is porous and capable of absorbing hardener composition and that the resin component is subsequently applied to the same joint surface. Preferably this is also applied by means of a roll. A suitable device for carrying out the process comprises a roll having a porous and absorbing material on its surface and a dosage roll which is in contact with this and between which rolls the hardener component is supplied.
Patent NO-832211-L (NO)
Title: Platefilter
Inventor: LINSER JOERG
IPC: B01D25/127
Filed: 1983-06-17
Abstract: Platefiler med flere filterplater som oppviser filterkamre og som er sammenpressbare ved hjelp av en presseinnretning. Mellom filterplatene (1) er det ført et filterbånd (2), som er omkastet over brytruller (3). Filterplatene (1) kan ved åpning av presseinnretningen bringes til innbyrdes avstand for fjerning av filterkakene. Filterbåndet (2) er oppdelt i flere enkelt, innbyrdes forbundne båndsegmenter (4), hvis lengde- og breddedimensjon er tilnærmet de samme som på filterplaten (1). I det minste ved en av filterbåndes lengdesider er det anordneen dreveog med båndseqmenene <4t for-. bundet drivinnretning (7).
Patent NO-844981-L (NO)
Inventor: LINDEN GUENTHER
IPC: B65B1/36
Filed: 1984-12-12
Abstract: An apparatus for packaging snuff ready for use in the form of portions enclosed, for example, in a paper sachet (3, ε) from a snuff store. The apparatus is characterizing in that the portioning means (3,9) is arranged to compress the snuff portion in a portion pocket (9), wherewith each portion pocket comprises a through-passing opening in a portion conveyor (4). The compressed snuff portions are blown by pneumatic means (11, 14) to an intended position in a packaging band (16).
Patent NO-852632-L (NO)
Inventor: OUDEJANS JOHANNES CORNELIS
IPC: C11C3/12
Filed: 1985-07-01
Abstract: The invention provides a hydrogenation catalyst which contains 10-90 parts by weight of a metal/metal compound and 9-10 parts by weight of silica and has a total active metal surface area of 1 to 20, preferably more than 2 m<2>/g of metal and in which the metal has an uneven atomic number between 26 and 30, characterized in that the catalyst contains metal/metal compound aggregates, the average particle size of which is between 5 and 50 micrometers and the metal/metal compound aggregates are for at least 60, preferably at least 80, more preferably at least 90%, free of carrier particles. The invention also provides a method for preparing such catalysts and a process for the hydrogenating unsaturated compounds using such a catalyst.
Patent NO-860891-L (NO)
Title: Betongbeskyttelse av undervannsinstallasjoner.
Inventor: BAUMANN LUDVIG
IPC: E21B/
Filed: 1986-03-10
Abstract: Betongkonstruks jon for beskyttelse av undervannsinstallasjoner, med en nedre seksjon (3) bestående av ekrfistilte betongvegger (7) med adkomståpninger og en øvre seksjon bestående av et delt lokk. Den nedre seksjon har adkomståpninger med skråstilte vegger (4) og opplegg for et hovedlokk (5) med en eller flere koniske utsparinger (6) for mindre selvsentrerende lokk (8). Lokkene (6, 8) har en indre kjerne fyllt med en lett stapemasse (9) ilagt finmasket stålnett (10), og lommer (11) for påvisning av mulig lekkasjegass.
Patent NO-860901-L (NO)
Title: Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater.
Inventor: DAVIES JOHN SIDNEY
IPC: C07H17/08
Filed: 1986-03-10
Abstract: 11-eter-derivater av erytromycin og tilsvarende 9-(eventuelt substituert)-amino, 9-imino- og. 9-(eventuelt substituert)-oksim-derivater er nye antibakterielt aktive forbindelser og kan fremstilles ved alkylering av 11-hydroksygruppen under milde betingelser .
Patent NO-872667-L (NO)
Inventor: GAWIN IRENA
IPC: C08K7/00
Filed: 1987-06-25
Abstract: Damage tolerant composites comprising high strength filaments in the form of bundles or tows of continuous fiber and a tough phase separated, crosslinked epoxy resin matrix are disclosed. The crosslinked epoxy resin matrix comprises infusible particles that reside primarily between plies of the composite and critically have a median particle size between l0 - 75 microns. Prepregs for making the damage tolerant composites and methods of making such prepregs and the epoxy resin compositions thereof are also disclosed. The epoxy resin compositions comprise the infusible particles which become segregated as to size on a surface layer of the prepreg during the process of combining the high strength filaments of the prepreg and the resin containing the epoxy resin composition. Alternatively, the infusible particles may be disposed directly on the epoxy resin surface of the prepreg.
Patent NO-880541-L (NO)
Title: Krympbar hylse av tekstilmateriale innsatt med polymermateriale.
Inventor: OVERBERGH NOEL MARCEL MICHIEL
IPC: H02G15/18
Filed: 1988-02-08
Abstract: Varmgjenvinnbar rørformet hylse eller omleggingshylse, som har et forra-gjenvinningsforhold pa minst 40% og er i stand til a innkapsle en skjøt mellom langstrakte gjenstander.Hylsen omfatter (a) et polymermatriksma-teriale og (b) et fonngjenvinnbart tekstilmateriale ved hjelp av hvilket hylsen er gjort formgjenvinnbar, hvilket tekstilmateriale er gjort ugjennomtren-gelig ved hjelp av matriksmaterialet og omfatter varragjenvinnbare veftfibere som strekker seg rundt hylsens omkrets i bunter pa 2-6 fibere, og ikke fortn-gjenvinnbare varpfibere som strekker seg i hylsens lengderetning.6x .
Patent NO-881391-L (NO)
Inventor: KROPP HANS-ERIK
IPC: F42C19/06
Filed: 1988-03-29
Abstract: The present invention relates to an armour piercing explosive shell of the kind which comprises a hollow charge and an impact contact member placed in the nose cone (1) of the shell an arranged to provide electrical contact for initiation of the hollow charge upon impact of the shell against the target. To improve the penetrative performance of the shell against targets protected by active armour the nose cone (1) of the shell is provided with a reinforced tip (2) for mechanical penetration of the active armour and the impact contact member does not extend all the way to the tip but positioned behind an inner shoulder (8) made in the wall of the nose cone (1).
Patent NO-904141-L (NO)
Title: Blodtappingsapparat og anvendelse av samme.
Inventor: HANSBY MARIA
IPC: A61B/
Filed: 1990-09-24
Abstract: En blodoppsamlingsenhet omfatter en slange (hovedslange). (2), hvilken hovedslange (2) ved sin ene ende har en kanyle (1) som skal stikkes inn i en blodgivers vene og ved sin annen ende har et kar (3) for oppsamling av blod fra blod-giveren. Det karakteristiske trekk består i at hovedslangen (2) har en tvegrening (4) beliggende mellom kanylen (1) og karet (3) samt forsynt med en andre slange (6), en såkalt sekundærslange, som (a) ved sin ytre ende muliggjør oppsamling av små blodmengder (blodprøver) og (b) er utstyrt med en anordning (5) som forhindrer væskestrømning gjennom sekundærslangen (6) og er konstruert på en slik måte at den kan åpnes ved utenfra påvirkning, slik at væske deretter settes i stand til å strømme gjennom sekundærslangen (6).
Patent NO-910970-L (NO)
Inventor: ROTHE ECKHARD
IPC: G02C7/04
Filed: 1991-03-12
Abstract: Contact lenses having position stabilization are utilized in order to fix the position of the contact lens on the cornea of the eye of a person wearing the lens. For this purpose, thickened regions for adjusting a specific orientation relative to the eye of the wearer are provided on the convex outer surface of the contact lens outside of the optical zone. A reliable position stabilization of a contact lens on the eye is achieved in that at least two thickened regions are provided laterally of the vertical center axis. These thickened regions extend essentially below a horizontal center axis between the optical zone and the edge region and it is very advantageous if these thickened regions lie at least at one point on the lower eyelid when the eye is open. In this way, a rotation of the contact lens is avoided when the eye is open. Furthermore, it is advantageous when the contact of the thickened regions on the lower eyelid is maintained. Additional thickened regions can be provided on the outer surface by which the movement of the upper eyelid encounters resistance when moving downwardly. These additional thickened regions are arranged above the first-mentioned thickened regions. With this combination, an optimal position stabilization of the contact lens on the cornea of the eye is achieved. The possibility is also presented that the thickened regions can be configured that they provide static as well as dynamic position stabilization.
Patent NO-913847-L (NO)
Inventor: TACHON PIERRE
IPC: A61K31/485
Filed: 1991-10-01
Abstract: A pharmaceutical delivery system includes a dispenser pack containing a pharmaceutical composition. The composition includes a pharmaceutical active principle homogeneously distributed in a water-dispersible gel excipient containing an acrylamide or acrylamidine gelling agent.
Patent NO-920456-L (NO)
Inventor: SEGER LEIF
IPC: H02G3/12
Filed: 1992-02-04
Abstract: The invention relates to a cover for an electrical socket combination which consists of at least one electrical socket (130) which is mechanically fixed to a wall or in an electrical duct (10), such as a flush-mounted socket, a plug socket or the like. The edge formed by the edge of the electrical socket (130) or the edges (132) of adjacent electrical sockets is used to form the edges of the cover (108). <IMAGE>
Patent NO-920532-L (NO)
Inventor: CHATO JOHN D
IPC: F24H1/26
Filed: 1992-02-11
Abstract: A pulsating combustor includes a combustion chamber having a hollow cylindrical form and a tailpipe having a similar hollow cylindrical form, such that the internal chambers are annular in section. Air and fuel are admitted to the combustion chamber and pulsating combustion is initiated, with exhaust gases being removed from the tailpipe. A water jacket is defined both inside and outside the pulsating combustor, with water being moved from one to the other as it is being warmed. Fuel is preferably admitted along needles or short pipes which are such as to have a natural resonant frequency which is a small number multiple of the natural resonant frequency of the combination of the combustion chamber and the tailpipe. Preferred frequencies are 440 cps for the combination combustion chamber and tailpipe, and 1320 cps for the fuel delivery needle or pipe.
Patent NO-930085-L (NO)
Inventor: KROEGER ROLF
IPC: B05D7/02
Filed: 1993-01-11
Abstract: PCT No. PCT/EP91/01322 Sec. 371 Date Jan. 15, 1993 Sec. 102(e) Date Jan. 15, 1993 PCT Filed Jul. 12, 1991 PCT Pub. No. WO92/01517 PCT Pub. Date Feb. 6, 1992.A method of coating heat sensitive materials with powder paint is described, which is based on repetitive heating cycles of paint coating by radiation example infrared, interspersed with cooling cycles, which there is a temperature difference between the paint coating and substrate such as to allow the filmation and subsequent curing of the paint without damaging the substrate.
Patent NO-930911-L (NO)
Title: Mottaking av frekvensdelte, ortogonale multiplekssignaler
Inventor: GLEDHILL JEFFREY JOHN
IPC: H04L/
Filed: 1993-03-12
Abstract: I et OFDM-signal moduleres individuelle OFDM-bærere med sampler av signaler, som kun kan ta et begrenset antall tillatte verdier, og en blokksampler modulerer gruppen av bærere i løpet av en tidsperiode T. I en mottaker kan signalet som modulerer en invididuell OFDM-bærer demoduleres ved å estimere posisjonene til referanseakser som tjener som referanseramme mot hvilken de tillatte modulerende verdiene er definert, og å multiplisere verdiene av de demodulerte samplene med den kompleks-konjugerte for et punkt på én av de estimerte referanseaksene. Spredningen av samplingsgruppene demodulert fra hver OFDM-bærer gir en indikasjon på hvorvidt mottakeren er synkronisert med blokkgrensene. Spredningen av de komplekse samplene evalueres fortrinnsvis kun i radiell retning, og benyttes til å styre samplingsklokkens frekvens. Fase-avdrift av de demodulerte samplene fra én blokk til den neste, indikerer graden av frekvensfeil i lokal oscillator. Fase-avdrift blir fortrinnsvis målt ved å multiplisere komplekse verdier med den kompleks-konjugerte for et tidligere sampel demodulert fra den samme OFDM-bæreren, og ved å benytte det resulterende måltallet til å styre den lokale oscillatorens frekvens via en frekvenslåst sløyfe.
Patent NO-931355-L (NO)
Title: Dypboringssement og fremgansmaate for fremstilling av denne
Inventor: RUDERT VOLKHART
IPC: C04B16/04
Filed: 1993-04-13
Abstract: En dypboringssement består av et hydraulisk bindemiddel og eventuelt tilsetningsmidler og tilsetningsstof- fer. For at et slam med lav tetthet fremstilt fra disse skal få høye fast- heter blir kunstoffpulver innblandet i en mengde av 50-800 kg/m3 slam, idet kunststoffpulveret består av seighårde eller sprøe, lutbestandige partikler med en kornstørrelse som er mindre enn 2 mm og som ikke er fylt eller er lite fylt og får deres strekkfasthet dras- tisk redusert i det minste først ved 10°C over den angjeldende maksimale statiske borehulltemperatur.
Patent NO-931718-L (NO)
Inventor: MITTENDORF JOACHIM
IPC: C07C69/753
Filed: 1993-05-11
Abstract: Cyclopentane- and -pentene- beta -amino acids of the general formula (I) <IMAGE>  in which   A, B, D, E, G, L, M and T are identical or different and, with the proviso that at least one of the abovementioned substituents is H, represents hydrogen, halogen, benzyl, hydroxyl or optionally substituted alkyl with up to 8 carbon atoms, or in each case B and D, E and G or L and M together represent a radical of the formula <IMAGE>     or =N-OH, or E and G and/or B and D together represent the radical of the formula =O or =S, or B, D, E and G or E, G, L and M each together form a radical of the formula <IMAGE> in which D' and G' have the abovementioned meaning of D and G, but do not both denote hydrogen and G and L have the abovementioned meaning   V is an oxygen or sulphur atom or the -NH group, R<1> is hydrogen, optionally substituted alkyl or optionally substituted phenyl or, if V is the -NH group, is the group of the formula -SO2R<8>, R<2> is hydrogen, an amino protective group customary in peptide chemistry, optionally substituted alkyl with up to 8 carbon atoms, acyl with up to 8 carbon atoms, optionally substituted benzoyl, a group of the formula -SO2R<8> or an amino acid residue of the formula   <IMAGE>   R<3> is hydrogen or optionally phenyl-substituted alkyl with up to 8 carbon atoms, or R<2> and R<3> together represent the radical of the formula =CHR<14>, process for their preparation and their use as pharmaceuticals, especially antimycotic pharmaceuticals, are described.
Patent NO-931876-L (NO)
Title: Fremgangsmåte ved mating for aluminium-elektrolyse
Inventor: KUMPULAINEN VESA
IPC: C25C/
Filed: 1993-05-24
Abstract: Det er beskrevet en fremgangsmåte for mating av råmateriale som for eksempel alumlnlumnoksyd til aluminlumelektrolyse ved å bruke vekselvirkende vlbrerende mateorgan (5). Råmaterialet føres til en kontrollboks (7) plassert i nærheten av elektrolytt- smeltens (9) overflate. Ved mateorganet (5) anordnet inne i kontrollboksen (7) er det rettet mekanisk vibrasjon (V). Den vertikale amplituden til vibrasjo- nen (V) er valgt innen området 0,5 til 1,5 cm. Osclllasjonsfrekvensen er valgt i området 11 til 40 Hz. Råmaterialet mates ved hjelp av mateorganet (5) kontinuerlig gjennom en åpning (9) dannet i elek- trolyttskorpen (8) rundt kontrollboksen (7).
Patent NO-941060-L (NO)
Title: Fremgangsmåte og anordning for å bestemme tykkelsen på halvledersjikt
Inventor: LEDGER ANTHONY M
IPC: H01L21/66
Filed: 1994-03-23
Abstract: Anordning og fremgangsmåte for å bestemme tykkelsen på hele overflaten til en tykk halvleder (94) med et sjikt på en isolator. Overflaten deles inn i flere piksler ved å variere lengden til en optisk bane (110) med variabel lengde i et Michelson-interferometer (66) med en infrarød kilde (62), belysning av hele overflaten til sjiktet med et bilde av IR-kilden i løpet av lengdevariasjonsoperasjonen og detekterlng (64) av produktet av intensiteten (Is(z)) fra Michelson- interferometeret og refleksjonen E(t) til sjiktet ettersom banelengden varieres. Produktet er indikativt for tykkelsen av sjiktet, og ved å bestemme for hver piksel hvilke av grupper med lagrede reflektansverdler for en korresponderende antall tykkelser, gir beste sammenligning med de detekterte verdiene et tykkelses- kart av halvledersjiktet.