Patent SG-11201804484Y-A (SG)
Title: Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
Inventor: BRANDOLINI LAURA
IPC: A61K31/165
Filed: 2017-01-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111 01110111010111111 OM 10111110H III International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/121838 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/165 (2006.01) A61P 25/02 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/19 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/050637 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 13 January 2017 (13.01.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 16151618.2 15 January 2016 (15.01.2016) EP (84) Designated States (unless otherwise indicated, for every 16190871.0 27 September 2016 (27.09.2016) EP kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: DOMPE' FARMACEUTICI S.P.A. [IT/IT]; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Via San Martino della Battaglia, 12, 1-20122 Milano (MI) TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (IT). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: BRANDOLINI, Laura; c/o Dompe farmaceut- ici S.p.A., Via Campo Di Pile s.n.c., 1-67100 L'Aquila SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (AQ) (IT). RUFFINI, Pieradelchi; c/o Dompe farmaceut- — ici S.p.A., Via Campo Di Pile s.n.c., 1-67100 L'Aquila Declarations under Rule 4.17: — = (AQ) (IT). ALLEGRETTI, Marcello; c/o Dompe farma- - ceutici S.p.A., Via Campo Di Pile s.n.c., 1-67100 L'Aquila of inventorship (Rule 4.17(iv)) = (AQ) (IT). Published: (74) Agents: PISTOLESI, Roberto et al.; Via Nino Bixio, 7, I- — with international search report (Art. 21(3)) 20129 Milano MI (IT). = = (54) Title: IL-8 INHIBITORS FOR USE IN - PATHY = = Fig. 1 = = = = 50 = _ _ -53 40- . .. _ O9 30 , - 1 i 26 GC 1 er) st- %- GC 11 ei a 1 THE TREATMENT xxx 1 OF .44 - 1¢ I 11 RA. CHEMOTHERAPY E3 IIIII CM Mt. 4' -INDUCED PERIPHERAL NEURO- SHAM CONTROL DF2627A-TREATED 1-1 -1 5 1 10 14 IN Day 1-1 N (57) : The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1 /CXCR2 receptor inhibitors, use- ful in the treatment and/or prevention of chemotherapy-induced neuropathy, preferably in the treatment and/or prevention of chemo - Q therapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.