Patent SG-11201807301S-A (SG)
Title: Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
Inventor: KEMP MARK IAN
IPC: C07D498/20
Filed: 2017-03-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 011010111 11111 011011100 111110 ill OEN 11 International Bureau .. .... ..Yejd ..... .....!;,..1 (10) International Publication Number (43) International Publication Date WO 2017/149313 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: (Building 280), Cambridge Cambridgeshire CB22 3AT C07D 471/10 (2006.01) A61K 31/537 (2006.01) (GB). CO7D 471/20 (2006.01) A61P 35/00 (2006.01) CO7D 498/20 (2006.01) A61P 29/00 (2006.01) (74) Agent: STRATAGEM IPM LIMITED; Meridian Court, A61K 31/4353 (2006.01) Comberton Road, Toft, Cambridge CB23 2RY (GB). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/GB2017/050565 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 2 March 2017 (02.03.2017) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 1603779.8 4 March 2016 (04.03.2016) GB TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: MISSION THERAPEUTICS LIMITED ZA, ZM, ZW. [GB/GB]; Babraham Research Campus, Moneta Building (84) Designated States (unless otherwise indicated, for every (Building 280), Cambridge Cambridgeshire CB22 3AT kind of regional protection available): ARIPO (BW, GH, (GB). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: KEMP, Mark Ian; c/o Mission Therapeutics TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, — Limited, Babraham Research Campus, Moneta Building TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, _ (Building 280), Cambridge Cambridgeshire CB22 3AT DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (GB). STOCKLEY, Martin Lee; c/o Mission Therapeut- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = ics Limited, Babraham Research Campus, Moneta Building SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (Building 280), Cambridge Cambridgeshire CB22 3AT GW, KM, ML, MR, NE, SN, TD, TG). (GB). WOODROW, Michael David; c/o Mission Thera- Published: peutics Limited, Babraham Research Campus, Moneta = Building (Building 280), Cambridge Cambridgeshire CB22 with international search report (Art. 21(3)) = 3AT (GB). JONES, Alison; c/o Mission Therapeutics — Limited, Babraham Research Campus, Moneta Building = = = (54) Title: SPIRO-CONDENSED PYRROLIDINE DERIVATIVES = = = = = 7 H N %,.. AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS „la ri 1.? r, K SE Ny __ A N * tr 1-1 M 1-1 en CI' iv 1-1 IN 1-1 (57) : The present invention relates to novel compounds N enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer. (Figure (I)) 1k: 1 f 1 ti (I) and methods for the manufacture of inhibitors of deubiquitylating