Patent SG-11201804706U-A (SG)
Title: Open-top microfluidic devices and methods for simulating a function of a tissue
Inventor: VARONE ANTONIO
IPC: C12M1/42
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date .... ....r .„,„1 8 June 2017 (08.06.2017) IN I PO I PCT ID Hit (10) WO International 2017/096285 111111111111111111IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIIIIIIIIII Publication Al Number (51) International Patent Classification: Quebec H8R 2M4 (CA). NGUYEN, Justin, K.; 45 Cross C12M 1/00 (2006.01) C12M 3/00 (2006.01) Street, Apt. 24, Medford, Massachusetts 02115 (US). C12M 1/34 (2006.01) C12M 3/04 (2006.01) C12M 1/42 (2006.01) C12Q 1/02 (2006.01) (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, 70 W. Madison St., Suite 3500, Chicago, Illinois 60602- (21) International Application Number: 4224 (US). PCT/US2016/064798 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 2 December 2016 (02.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/263,225 4 December 2015 (04.12.2015) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (71) Applicant: PRESIDENT AND FELLOWS OF HAR- SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, YARD COLLEGE [US/US]; 17 Quincy Street, Cam- TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, bridge, Massachusetts 02138 (US). ZW. (72) Inventors: VARONE, Antonio; 865 Boylston Street, (84) Designated States (unless otherwise indicated, for every Newton, Massachusetts 02461 (US). WEN, Norman; 865 kind of regional protection available): ARIPO (BW, GH, Boylston St., Apt. 5, Newton, Massachusetts 02461 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, LEVNER, Daniel; 55 Sewall Avenue, Apt. 5C, Brookline, Massachusetts 02446 (US). NOVAK, Richard; 42 Rock- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Street, Unit 4, Jamaica Plain, Massachusetts 02130 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, view LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (US). MCPARTLIN, Lori; 49 Twombley Ave., North SM, TR), OAPI BJ, CF, CG, CI, CM, GA, GN, GQ, (BF, Billerica, Massachusetts 01862 (US). INGBER, Donald, GW, KM, ML, MR, NE, SN, TD, TG). E.; 162 W. Canton St., Boston, Massachusetts 02118 (US). CHOE, Youngjae; 35 Rose St., Somerville, Massachusetts 02143 (US). LENG, Lian; 8985 LaSalle Blvd., LaSalle, [Continued on next page] (54) Title: OPEN-TOP MICROFLUIDIC DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A TISSUE 300 334 0 320 342 -344 340 11 - - - - - - _- - . - -, _- 348 .4t 325 \ 305 GC \. 3 36 N Cr\ FIG. 3 0 IN 1-1 (57) : A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first N structure defmes a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defmes a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The C membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber. WO 2017/096285 Al MIDEDItitiDEIRDEFEDIECHHOHERUDIMIE Declarations under Rule 4.17: Published: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) — with international search report (Art 21(3)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii))