baber/WOPTO huggingface dataset:
Patent NZ-589036-A (NZ)
Title: AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
Inventor: BLANCHETOT CHRISTOPHE
IPC: A61K39/395
Filed: 2009-05-18
Abstract: Discloses nanobody polypeptides that specifically bind the human CXCR4. The nanobodies are generated by a method, comprising at least the steps of: 1. immunizing a Llama with whole cells that are alive and express the humanCXCR4 on their surface; 2. selecting for binding for human CXCR4; and where 3. the polypeptide displaces more than 50%, of human CXCL12 at high concentrations (? 100 nM) when bound to human CXCR4 in a competition binding assay; and/or 4. the polypeptide fully antagonizes the chemoattractant effects of human CXCL12 to human CXCR4 in a concentration that is equal or lower than 100 nM; and 5. where if the polypeptide comprises two or more nanobody, the polypeptide further comprises one or more peptide linkers Further discloses the nanobody framework and CDR regions comprising SEQ IDs as disclosed. Further discloses are pharmaceutical compositions of the nanobodies and a use of the nanobody in the manufacture of a medicament to treat cancer or AIDS. A nanobody is an antibody fragment consisting of a single variable antibody domain.
Patent NZ-590924-A (NZ)
Title: Humidification of respiratory gases
Inventor: ROW NATHAN JOHN
IPC: A61M16/16
Filed: 2009-09-17
Abstract: 590924 Disclosed is a humidifier (14) for humidifying a flow of breathable gas to be delivered to a patient. The humidifier includes a chamber (16) configured to receive the flow of breathable gas; a tub (20) configured to contain a supply of water, the tub being configured to be inserted into the chamber; a lid (18) provided on the chamber and being movable between an open position and a closed position; and a seal (19) provided on the lid, the seal being configured to seal the chamber such that the flow of breathable gas pressurizes the chamber. The humidifier may be connectable to a flow generator (12) configured to generate the flow of breathable gas. A tube for delivering the humidified flow may be connected to the humidifier. The tube may be a heated or non-heated tube. A respiratory apparatus for delivering a flow of breathable gas to a patient may include the humidifier and the flow generator and/or the tube.
Patent NZ-594245-A (NZ)
Title: Pharmaceutical composition containing an anionic drug, a cationic lipid and an amphiphilic block copolymer
Inventor: KIM SE-HO
IPC: A61K31/56
Filed: 2009-12-24
Abstract: composition for delivery of an anionic drug comprising an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug is nucleic acid material, the cationic lipid is a cationic lipid forming a complex with the nucleic acid material by electrostatic interactions, and the amphiphilic block copolymer is an A-B type di-block copolymer comprising of a hydrophilic A block and a hydrophobic B block, where the hydrophilic A block is one or more selected from the group consisting of polyalkyleneglycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylamide, a derivative thereof, and combinations thereof, and the hydrophobic B block is one or more selected from the group consisting of polyester, polyanhydride, polyamino acid, polyorthoester, polyphosphazine, and combinations thereof, and wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer.
Patent NZ-598188-A (NZ)
Title: System and method of wireless enabled device configuration over an advanced metering infrastructure (ami)
Inventor: REE BRADLEY RICHARD
IPC: G01F15/00
Filed: 2012-02-13
Abstract: A method and a system for configuring a device over a network are disclosed. The system (108) comprises a memory; and a processor operably connected with the memory. The processor is configured to receive, from a first device (106) via a first network (110), information about one or more wireless access points accessible by the first device; receive, from a second device (206) via a second network (208), configuration information for the first device for configuring the first device to connect to a wireless network (202) through one of the one or more wireless access points (208); and configure the first device using the configuration information. The configuring includes sending at least a portion of the configuration information to the first device via the first network.
Patent NZ-601091-A (NZ)
Title: Coaxial arrangement for utility such as sign on end of post with attachment part rotatable relative to post, and rotatable part indexable relative to attachment, with abutments to terminate rotation
Inventor: WOOD DANIEL
IPC: E01F9/669
Filed: 2012-07-05
Abstract: A mounting arrangement l0 is disclosed for mounting a utility 26 to an end 16 of a post 17. The mounting arrangement 10 includes an attachment member 11 for attachment to the post 17 which is fixed against rotation when attached to the post 17. A rotatable member 12 is connected to the attachment member 11 and is rotatable relative to the attachment member 11 about the axis of the post 17, The rotatable member 12 includes a connection arrangement 13 for connecting a utility 26 to the rotatable member 12, so that the utility 26 can rotate with the rotatable member 12, The rotatable member 12 is rotatable between first and second positions and a cooperating arrangement which comprises at least one abutment 35, 37, 38 is provided for cooperation with the rotatable member 12 to facilitate accurate return of the rotatable member 12 from the second position to the first position.
Patent NZ-601194-A (NZ)
Title: Compounds as bradykinin b1 antagonists
Inventor: WALTER RAINER
IPC: C07D405/12
Filed: 2011-02-21
Abstract: Disclosed herein are compound of general formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumour pain, headache diseases and osteoarthritis. In some embodiments the compound includes (S)-6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid-{ 3-[4-(4-chloro-2-trifluoromethyl-phenylamino)-2-fluoro-benzylcarbamoyl]-tetrahydrofuran-3-yl} -amide, and 6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid-(1-{ [5-(4-fluoro-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl} -cyclopropyl)-amide.
Patent NZ-601350-A (NZ)
Title: Method of treating arthritis
Inventor: BARDWELL PHILIP
IPC: A61K31/496
Filed: 2008-11-14
Abstract: ABSTRACT - 601350 The disclosure relates to the use of arylsulfonamide compounds of formula (I) in the manufacture of a medicament for the treatment of arthritis, wherein the variables are as defined in the specification.
Patent NZ-602522-A (NZ)
Title: Biosynthetic proline/alanine random coil polypeptides and their uses
Inventor: SKERRA ARNE
IPC: A61K38/00
Filed: 2011-05-20
Abstract: Discloses a drug conjugate comprising a) a biosynthetic random coil polypeptide or polypeptide segment comprising an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least 50 proline and alanine amino acid residues and b) a drug selected from i)a biologically active protein and ii) a small molecule drug.
Patent NZ-602879-A (NZ)
Title: A rack system and bracket
Inventor: DRAKE NICOLLE
IPC: A47G29/02
Filed: 2011-03-10
Abstract: Disclosed is a rack support system for retail or storage purposes to provide a secure connection between a bracket and a upright support. The support system comprises a support panel having a front face and a rear face and at least one aperture extending through the support panel between the front face and the rear face. The rear face includes a recess adjacent to the aperture with the recess having a base surface which in side view is located between the front face and the rear face. The base surface of the recess is bounded by at least one sidewall extending inward from the rear face, and the base surface of the recess intersects with a wall that extends forward toward the front face and that defines the aperture. The support panel is configured to be secured to a plate member. A support member has a body and at least one support hook which has a first portion to engage an edge of the at least one aperture with the body extending away from the first portion. The support hook has a second portion which extends from the first portion so as to form a gap or slot between the body and the second portion to receive a part of the support panel adjacent the at least one aperture. The second portion in use is adapted to be generally parallel to a rear surface of the support panel, wherein the second portion of the support hook can pass through the aperture and when the first portion has been positioned against a wall of the aperture the second portion is located adjacent a rear surface of the support panel and adjacent the plate member. The aperture of the support panel defines an opening that is surrounded by at least the wall. The first portion and second portion of the hook are configured such that both the first and second portions of the hook pass through the opening of the aperture in use and the second portion of the hook engages the rear surface of the support panel adjacent the aperture in use.
Patent NZ-602911-A (NZ)
Title: Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
Inventor: DHENDE VIKRAM
IPC: C08G73/04
Filed: 2011-04-28
Abstract: Disclosed is a polymer comprising: a linear or branched polyethylenimine polymer that has been quaternized with a hydrophobic side chain moiety and a photo-reactive moiety, wherein the hydrophobic side chain includes a C=C group in the chain and/or attached to the chain. Also disclosed is a structure, comprising: a surface having a polymer as defined above covalently attached to the surface, thereby providing the structure with antimicrobial properties. Further disclosed is a linear or branched polyethylenimine polymer derivative that obtained by reaction of a polyethylenimine polymer with a reagent for introducing a photo-reactive moiety (such as 4-[(6-bromohexyl) oxy] benzophenone) and a reagent for introducing a hydrophobic side chain moiety (such as 11-bromo-1-undecene).
Patent NZ-608833-A (NZ)
Title: Streaming hierarchy traversal renderer
Inventor: BURLEY BRENT
IPC: G06T15/80
Filed: 2013-03-28
Abstract: Disclosed is a computing device (100) for providing a streaming hierarchy traversal renderer. The computing device (100) has a processor (112) configured to arrange a scene into a spatial hierarchy (126), the scene having a plurality of scene nodes (124). The processor generates a plurality of directional queries for tracing in the scene and processes the directional queries using a streaming hierarchy traversal of the spatial hierarchy (126). Finally, the processor shades an output image (128) based on the streaming hierarchy traversal.
Patent NZ-609742-A (NZ)
Title: Aqueous solution of ambroxol
Inventor: PASSETTI GIANLUIGI
IPC: A61K9/00
Filed: 2011-12-22
Abstract: 609742 Disclosed herein is an aqueous solution comprising an acid addition salt of ambroxol, wherein the ambroxol content is ranging from 0.1% to 7% (w/v), the total content of polyalcohols selected from polyols and polyalkyleneglycols is at least 20% (w/v), the total content of alcohols is lower than 1% (w/v), and said aqueous solution is free of benzoic acid and/or salts thereof with organic or inorganic bases.
Patent NZ-615177-A (NZ)
Title: Methods of targeted treatment of frontotemporal lobar degeneration
Inventor: PATZKE HOLGER
IPC: C07D267/20
Filed: 2012-03-26
Abstract: Provided are methods of treating frontotemporal lobar degeneration (FTLD) or frontotemporal dementia (FTD) using dibenzooxazepine compounds of the general formula (IV), where the variables are as defined in the specification. Examples of the compounds include (Z)-4-(dibenzo[b,f][1,4]oxazepin-11-yl)-N-hydroxybenzamide and (Z)-N-hydroxy-4-(5-(2-morpholinoethyl)-5H-dibenzo[b,e][1,4]diazepin-11-yl)benzamide. Further, provided is the use of compounds such as 2-((1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-hydroxypyrimidine-5-carboxamide, N-hydroxy-N-methyl-4-((1S,4S)-5-p-tolyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)benzamide, (Z)-4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-N-hydroxybenzamide and (Z)-4-(benzo[f]thieno[2,3-b][1,4]oxazepin-5-yl)-N-hydroxybenzamide in the treatment of FTLD or FTD.
Patent NZ-618979-A (NZ)
Title: Crash barrier bracket
Inventor: DARREN COPELAND
IPC: E01F15/04
Filed: 2013-12-13
Abstract: A bracket (28) for supporting a rail (24) of a roadside crash barrier or parapet from a support post (12) is disclosed. In the case of a small vehicle, or relatively low impact crash, it is preferable for the parapet to have some flexibility to avoid bringing a vehicle to too sudden a stop. However, for higher impacts, particularly with larger vehicles, the barrier needs to be stiffer to absorb more of the impact and prevent the vehicle passing too far over the edge of the road. When a first part has collapsed by a certain amount, the impact is then transmitted into a second, stiffer part which will only collapse under a significantly higher impact. The bracket is formed from a single sheet of metal bent into a shape, which, when mounted to a post and supporting a rail, has a uniform horizontal cross-section including parallel front (40) and rear (42) panels for mounting to the rail and post respectively, and interconnecting sides (44, 46). The shape of the cross-section provides a first deformation mode of the bracket in the event of an impact to the rail exceeding a first impact level, and a second mode of deformation of the bracket in the event of an impact exceeding a second, higher impact level.
Patent NZ-628320-A (NZ)
Title: Treatment of psoriatic arthritis using apremilast
Inventor: DAY ROBERT
IPC: A61P19/02
Filed: 2014-03-13
Abstract: Disclosed is the use of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione (apremilast), alone or in combination with a second active agent, in the manufacture of a medicament for treating psoriatic arthritis.
Patent NZ-629360-A (NZ)
Title: Novel compounds for the treatment of dyslipidemia and related diseases
Inventor: PINGALI HARIKISHORE
IPC: C07D417/12
Filed: 2012-06-26
Abstract: Disclosed herein are compounds of formula (I) where the substituents are as defined herein. Also disclosed are pharmaceutical compositions containing them, methods for their preparation, the use of these compounds in medicine and the intermediates involved in their preparation. The compounds are suitable for the treatment of diseases and conditions such as hyperlipidemia and dyslipidemia. Particular examples of the compounds of formula I include 2-(4-(4-methyl-5-(p-tolyl)isoxazol-3-yl)phenoxy)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide and 2-(4-(2-(4-chlorophenyl)-4-methylthiazol-5-yl)phenoxy)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide.
Patent NZ-629672-A (NZ)
Title: A fish corral
Inventor: GOODRICK BRUCE
IPC: A01K75/00
Filed: 2013-04-24
Abstract: A corral for fish is disclosed. The corral has at least one wall (30) that defines a pathway (40) along which fish are able to travel wherein the pathway is inwardly winding or a spiral or helical or labyrinth shape. A fish holding vessel is also disclosed that attaches to the outlet of the corral. The wall may include gates (31) that allow the spiral to be reconfigured to a circuit to hold fish in the corral and also includes returns (32) that insure that fish travel along the pathway in the same direction.
Patent NZ-705306-A (NZ)
Title: Control assembly for a roller blind
Inventor: GREENING ANDREW
IPC: F16H7/20
Filed: 2013-09-02
Abstract: Disclosed is a control assembly for roller blind that aims to provide quick installation and easy repair. The assembly includes a chain wheel (4) adapted to be driven by an operating chain; a chain wheel support (8) configured to rotationally support the chain wheel (4); a drive bush (6) including a cylindrical body and a flange (32) provided at one end thereof; and a locking pin (10). At least one of the chain wheel (4) and drive bush (6) includes a coupling element (38) which in use couples the chain wheel (4) to the drive bush (6) such that axial displacement of the drive bush (6) results in a corresponding axial displacement of the chain wheel (4), but that relative rotational displacement between the chain wheel (4) and the drive bush (6) is permitted through an arc defined between a pair of opposed stops which are carried by the other of the chain wheel (4) and the drive bush (6). The locking pin (10) passes axially through the chain wheel (4) and the drive bush (6). The locking pin (10) includes at one end thereof a pair of opposed legs and at least one leg includes a locking lug adapted to engage a stop surface of the drive bush (6). The chain wheel support (8) includes a flange (50) which acts as an end plate for the control assembly and which is spaced from the drive bush flange (32) to define therebetween an operating chain channel. The drive bush flange (32) and the chain wheel support flange (50) each further include a chain cover element (52) which in use bridges a portion of the operating chain channel (24) to form an enclosed portion of the channel (24). The drive bush flange (32) is angled away from the body and defines a convex flange surface.
Patent NZ-707003-A (NZ)
Title: Treatment and prevention of mastitis
Inventor: BEUS CHAD S
IPC: A61P29/00
Filed: 2013-10-17
Abstract: Treating and Preventing mastitis employing cationic steroidal antimicrobials (CSAs). Treating or preventing clinical mastitis in a mammal includes administering a cationic steroidal anti-microbial compound (CSA) formulation to the intra-mammary organ of a mammal (e.g., a dairy cow), such as by injection into the mammary organ (e.g., through the teat of the mammary organ), and/or topical application. The dairy cow can be lactating and have a somatic cell count (SCC) less than or equal to 500,000 cells/mL at the time of administering the CSA formulation. Alternatively, the dairy cow can be lactating and have a somatic cell count (SCC) greater than 500,000 cells/mL at the time of administering the CSA formulation. The dairy cow can be taken out of production during the administration of the CSA formulation for a period of time of about 3 days or less, 2 days or less, or 1 day or less.
Patent NZ-711324-A (NZ)
Title: Synchronous-generator pole stack
Inventor: KELLING RALF
IPC: H02K1/24
Filed: 2014-04-03
Abstract: The invention relates to a synchronous-generator rotor pole stack, comprising a plurality of pole-stack sheets offset from each other, a pole shaft (410), and a pole head (420) having at least three pole-head segments (423a, 423b). A front edge of each of the at least three pole-head segments (423a, 423b) is arranged at an angle to the pole shaft (410).
Patent NZ-712639-A (NZ)
Title: Systems and methods for mobile device analysis of nucleic acids and proteins
Inventor: GOEL ANITA
IPC: G01N1/02
Filed: 2014-03-14
Abstract: Disclosed is a system for rapid analysis of biological samples and a method of operating the system. The system includes an integrated fluidic chip comprising an extraction module, an amplification module, and a detection module and a portable device configured to receive the integrated fluidic chip. The portable device and the integrated fluidic chip are together configured to perform at least one cycle of operations that includes the steps of extracting an analyte from a biological sample; generating one or more products from the analyte; and detecting the analyte or the one or more products generated from the analyte. The integrated fluidic chip and the portable device are capable of selectively applying nanoscale control during each of the extraction, generation, and detection operations.
Patent NZ-745549-A (NZ)
Title: Reflective switching device for inputting different wavelengths of light into waveguides
Inventor: JONES WILLIAM
IPC: G02B27/18
Filed: 2017-02-28
Abstract: Systems and methods are provided for selectively incoupling light having different wavelengths into a plurality of waveguides respectively. The systems and methods provided for selectively incoupling light having different wavelengths into one of a plurality of waveguides comprises a switching device which receives light from an optical projector. The switching device comprises switchable reflective elements that can be configured to redirect incoming light towards an incoupling optical element associated with one of a plurality of waveguides. Advantageously, utilizing a switching device to redirect incoming light towards an incoupling optical element may reduce the number of light sources needed to provide color illumination and that is used with displays that provide multiple depth planes for viewing. Such systems and methods may reduce weight, reduce size, or improve ergonomics of wearable display systems.
Patent NZ-753798-A (NZ)
Title: System and method for continuous microwave-assisted extraction of bioactive agents from biomass
Inventor: DRUGA MICHAEL
IPC: A23L5/30
Filed: 2017-11-27
Abstract: There is a high incidence, abundance, and variety of bioactive agents occurring in nature, particularly in materials of plant origin (i.e., biomass). In many cases, it is difficult to get the desirable effects of bioactive substances via direct consumption of fruits and vegetables due to their low overall concentration and the functional ballast of additional accompanying ingredients. Continuous flow microwave processing and subcritical water processing are emerging technologies that have potential in extraction applications, especially those focused on isolation of bioactive agents in plant materials. However, the implementation of continuous flow microwave technology and subcritical water technology has been constrained due to limited experience, inappropriate design, and narrow operational capabilities of currently available microwave equipment. The presently disclosed subject matter is directed to a system and method of extracting bioactive agents from biomass using continuous microwave-assisted extraction. The disclosed system comprises a plurality of microwave modules that exposes the biomass to continuous microwave energy, and an extraction module to extract bioactive agents from the biomass. In some embodiments, the biomass is exposed to subcritical water treatment in the microwave modules. The disclosed system enables bioactive agent to be extracted effectively, in a relatively short period of time compared to conventional extraction methods and allows for an enhanced extraction yield.
Patent NZ-754561-A (NZ)
Title: Foamable cleansing compositions
Inventor: KAMPS NICOLE
IPC: A61K8/44
Filed: 2018-02-22
Abstract: The invention describes a foamable skin and hand cleansing composition comprising the following components, in each case based on the total composition of the cleaning composition : a) 0.1 to 5% by weight of at least one emulsifier selected from PEG-18 castor dioleate, polyglycerine 4-caproate, hydrogenated castor oil, PEG-10 glyceryl dioleate, glycereth-7 caprylate/caprate, gemini surfactants and mixtures thereof; b) 0.5 to 7% by weight of at least one oil, especially an alkyl fatty acid ester; c) 0 to 10% by weight of at least one hydrophobic emollient; selected from polyol esters, and typically selected from PEG 7 glyceryl cocoate, polyglycerine 4 caprate, glycereth 2- cocoate, PEG-6 capryiic/capric glycerides, polyglyceryl 3 caprate, polyglyceryl 4-caparate and mixtures thereof; d) 5 to 20% by weight of at least one surfactant used as a soiling remover; e) 0.5 to 12% by weight of at least one fatty acid glucamide; f) 1 to 8% by weight of at least one surfactant used as a foamer; g) 0 to 1% by weight of at least one preservative; h) 0 to 1% by weight of a pH modifier; i) 0 to 10% by weight of one or more auxiliaries or additives; j) water to make up 100% by weight.