baber/WOPTO huggingface dataset:
Patent NZ-260851-A (NZ)
Title: 5-amino-1-cyclopropyl-8-methyl-4-oxo-7-pyrrolidinyl-quinoline -3-carboxylic acid derivatives and pharmaceutical compositions thereof
Inventor: ITO YASUO
IPC: A61P31/04
Filed: 1994-06-24
Abstract: A 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative represented by the general formula: <CHEM> wherein R<1> is a hydrogen atom or a lower alkyl group; R<2> is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl group or a residue of carboxylic acid ester; R<3> is a hydrogen atom or a lower alkyl group; R<4> , R<5> or R<6> are each independently a hydrogen atom or a lower alkyl group; or two of R<4>, R<5> and R<6> may be taken together to form a -(CH2) n - group wherein n is 1 or 2, a stereoisomer thereof, or a pharmacologically acceptable salt thereof, the process for preparing these compounds, a pharmaceutical composition comprising an effective amount of these compounds and methods for the treatment of infectious diseases through the administration to patients of an effective amount of these compounds, and intermediates of these compounds are disclosed. These compounds are effective as antibacterial agents.
Patent NZ-261933-A (NZ)
Title: Extracting sphingomyelin from phospholipid-containing fat concentrate
Inventor: NYBERG LENA
IPC: C11B1/10
Filed: 1994-02-10
Abstract: PCT No. PCT/SE94/00105 Sec. 371 Date Sep. 21, 1995 Sec. 102(e) Date Sep. 21, 1995 PCT Filed Feb. 10, 1994 PCT Pub. No. WO94/18289 PCT Pub. Date Aug. 18, 1994A method for extracting sphingomyelin from a phospho-lipid-containing fat concentrate is described. The method comprises the following steps: A. dissolving the fat concentrate in a solvent mixture of an essentially polar organic solvent and an essentially non-polar organic solvent, B. withdrawing a phase consisting mainly of the non-polar organic solvent and phospholipids dissolved therein, C. adding to the phase withdrawn in step B an organic solvent of intermediate polarity at a temperature of about 13 DEG -25 DEG  C., thereby forming a precipitate comprising mainly sphingomyelin, together with a viscous phase and a solvent phase, and then D. withdrawing the precipitate and the viscous phase, and separating them from one another.
Patent NZ-265054-A (NZ)
Title: 16-hydroxy prednisolone cyclohexanecarboxaldehyde acetal derivatives
Inventor: GUTTERER BEATE
IPC: A61K31/58
Filed: 1994-03-31
Abstract: PCT No. PCT/EP94/01015 Sec. 371 Date Sep. 29, 1995 Sec. 102(e) Date Sep. 29, 1995 PCT Filed Mar. 31, 1994 PCT Pub. No. WO94/22899 PCT Pub. Date Oct. 13, 1994Epimers of the compound having the formula (I) are disclosed, both in their pure form and mixed in any desire mix ratio.    <IMAGE>  (I)
Patent NZ-273847-A (NZ)
Title: Subterranean wells; method and apparatus for drilling multiple wells from a single bore, segregating means at wellhead for positioning first and second tubulars
Inventor: COLLINS GARY J
IPC: E21B43/14
Filed: 1994-09-16
Abstract: A process for drilling and completing multiple subterranean wells from a common well bore (9) and an assembly for guiding a drill string during drilling and casing during completion of such multiple wells. The assembly comprises a wellhead (6) located at or near the surface of the earth and positioned over the common well bore (9), at least two tubulars (30, 34) positioned within the common well bore, and means positioned at said wellhead (6) for segregating and supporting the tubulars. In accordance with the process, at least one subterranean well bore is drilled through one of the tubulars (30, 34) and into a subterranean formation and hydrocarbons can be produced from the subterranean formation to the surface via production casing and/or production tubing positioned within the subterranean well bore (9). Other subterranean well bores can be drilled in a similar manner through other tubulars of the assembly.
Patent NZ-335105-A (NZ)
Title: Process for alkylating hindered sulfonamides
Inventor: HAWKINS JOEL MICHAEL
IPC: C07C311/37
Filed: 1999-04-09
Abstract: The present invention relates to a process for alkylating hindered sulfonamides by Michael addition to propiolates and to novel intermediates prepared in this process. The compounds have the formula IV where, R1 is C1-6 alkyl or optionally substituted benzyl; R2 and R3 are independently C1-6 alkyl or R2 and R3 are taken together to form a three to seven membered cycloalkyl, pyran-4-yl ring or a bicyclo ring of the formula 1 where the asterisk indicates the carbon atom common to R2 and R3 Y is hydrogen or C1-6 alkyl Q is C1-6 alkyl, C6-10 aryl, C2-9 heteroaryl, and many other aryl groups no bigger than C10 which are substituted as disclosed in the disclosure. The process for the preparation of this compounds by reacting formula V with formula VI in the presence of a base and a polar solvent.
Patent NZ-335810-A (NZ)
Title: 3-(2-azetidinyl-methoxy)-pyridine derivatives useful as analgesics and azetidinyl intermediates
Inventor: HOLLADAY MARK W
IPC: A61K31/443
Filed: 1997-12-10
Abstract: An 3-(2-azetidinyl-methoxy)-pyridine derivative or a pharmaceutically acceptable salt thereof has the compound of formula I wherein: Z, Y, X and the 2-azetidine stereochemistry are, respectively, selected from: a) H, H, Me (R); b) H, H, CN (S); c) H, H, Cl (S); d) H, H, Cl (R); e) H, H, Br (R); f) H, H, F (S); g) H, H, F (R); h) H, H, CHF2 (S); i) H, H, OMe (R); j) H, Me, Cl (S); k) H, Me, Cl (R); l) H, Et, F (S); m) H, ethenyl, Cl (S); n) H, ethenyl, Cl (R); o) H, ethenyl, F (S); p) H, ethenyl, F (R); q) H, ethynyl, Cl (S); r) H, ethynyl, Cl (R); s) H, Cl, Cl (S); t) H, Cl, Cl (R); u) H, Cl, F (S); v) H, Br, Me (S); w) H, Br, Me (R); x) H, Br, Cl (S); y) H, Br, Cl (R); z) H, Br, F (S); aa) H, Br, F (R); bb) H, n-Pr, H (S); cc) H, ethenyl, H (S); dd) H, ethenyl, H (R); ee) H, Cl, H (R); ff) H, F, H (S); gg) H, NO2, H (S); hh) H, OEt, H (S); ii) Cl, H, H (S); jj) Cl, H, H (R); kk) F, H, H (S); ll) F, H, F (S); mm) F, H, Me (S) or nn) F, H, Me (R) and R is H or a prodrug such as methyl, ethyl, isopropyl, n-propyl, isobutyl, t-butyl, t-pentyl, n-pentyl, n-butyl, cyclohexylmethyl, 3-methyl-1-butyn-3 -yl, optionally N-protected-Ala, optionally N-protected-Phe, phthaloyl methyl ester, 4-diethylaminobenzoyl, 2-hydroxymethylbenzoyl, acetyl, t-butyloxycarbonyl, ethoxycarbonyl, phenoxycarbonyl, 4-nitrophenoxycarbonyl, 4-methoxyphenoxycarbonyl, 4-carbomethoxyphenoxycarbonyl, 4-methylphenoxycarbonyl, 4-fluorophenoxycarbonyl, 4-chlorophenoxycarbonyl, 2,6-dimethylphenoxycarbonyl, 1 -acetoxy-1-methyl-ethoxycarbonyl, benzyloxycarbonyl, pyrrolidin-1-ylcarbonyl, N-succinimidylmethyl or N-phthalimidylmethyl or a group of formula 1, 2 (where R' is H or Me), 3, 4 or 5 (where two azetidines are attached). A pharmaceutical composition thereof is useful in controlling pain in mammals. An intermediate compound of formula II is disclosed wherein: L is an anionic leaving group which may be displaced by a nucleophile and P is a nitrogen protecting group.
Patent NZ-504354-A (NZ)
Title: Polyethylene glycol matrix pellets for fast release of greasy, oily or sticky drug substances
Inventor: KARLSSON CHRISTER
IPC: A61K31/663
Filed: 1998-11-18
Abstract: A drug delivery system for oral administration in solid dry form of greasy/oily/sticky substance(s) and pharmaceutically active substance(s) or pharmaceutically active substance(s) is greasy/oily/sticky characterized by having a plurality of solid, polymeric matrix beads comprising considerable amounts of greasy/oily/sticky substances and having fast release characteristics and a process for the preparation of such solid, polymeric matrix beads comprising greasy/oily/sticky substances.
Patent NZ-505923-A (NZ)
Title: Laminated phenolic resin foamed board and its manufacturing method, with predetermined ratio of bending moduli in longitudinal and transverse directions
Inventor: WATANABE TAKAYASU
IPC: B29C44/56
Filed: 1999-02-05
Abstract: The disclosure is directed at providing a foamed phenol resin body laminate, which has excellent surface flatness, improved bending elasticity modulus in the longitudinal direction and bending strength, and improved flexibility, and its appropriate manufacturing method.
Patent NZ-507423-A (NZ)
Title: Collapsible  craypot or fishtrap  with  frame  members pivoting on diametrically opposed semi-circular rings
Inventor: MASON GREG MALCOLM LEWIS
IPC: A01K69/10
Filed: 2000-10-11
Abstract: The crustacean/fish trap has a rigid support  base  P, with  pivotally  attached frame members which  rotate  about diametrically  opposite pivot points on  base  P.  Permanent escape  apertures  Y are located on the  base  and/or  frame members.   A  closing mechanism retains at least  one  frame member  onto  the base. At least one opening R  is  provided for  crustaceans/fish to enter the trap. The  frame  members are  movable  from a first position where they  are  located close  to  the base P, and a second position where they  are raised  with netting extending over them. At least on  frame member is retained onto base P.
Patent NZ-509475-A (NZ)
Title: Air filter holder
Inventor: FACOORY PAUL
IPC: B01D27/08
Filed: 2001-01-22
Abstract: An air filter holder (100) for an air handling system, the holder including: a two-part body defining a passage between an air inlet (40) and an air outlet; means (5) and (6) for releasably connecting a first part (1) and a second part (2) of the two-part body, allowing access for the removal or insertion of a flat air filter (3); retaining means (7) for removably retaining the flat air filter within the body, said retaining means (7) including a mesh screen (4) (to support the filter cassette and prevent it from billowing) fixed to the first part (1) which co-operates with an annular face (8) of the second part (2) to hold the edge of the filter (4) there between, and wherein both the first (1) and the second parts (2) include adaptor means (30) for connection of at least two different size ducts. The air filter holder (100) is useful in an air handling system providing heating, ventilating or air conditioning in a building.
Patent NZ-509560-A (NZ)
Title: Tumor necrosis factor-gamma
Inventor: YU GUO-LIANG
IPC: C07K16/24
Filed: 1999-02-08
Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
Patent NZ-511303-A (NZ)
Title: Secreted and transmembrane polypeptides and nucleic acids encoding the same with homology to Hep27 protein
Inventor: WOOD WILLIAM I
IPC: C07K14/705
Filed: 1999-12-01
Abstract: An isolated nucleic acid having the nucleotide sequence shown in Figure 1(SEQ ID NO:1) and polypeptides having the amino acid sequence shown in Figure 2(SEQ ID NO:2) are described. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides and to methods for producing the polypeptides.
Patent NZ-514893-A (NZ)
Title: Separation of protective and automation functions in a protective relay for power systems
Inventor: SCHWEITZER EDMUND O
IPC: H02H3/00
Filed: 2001-10-17
Abstract: The system is for carrying out separate protection  and automation functions in a single relay-type  apparatus  for protection  logic equations and automation logic  equations. The  two sections are accessible by different passwords,  to maintain  separation and autonomy between the  two  sets  of logic   equations.  The  results of  the  protection  logic equations are stored in a protection information portion  of a  system  database, while results of the automation  logic equations  are  stored in an automation information portion of  a  system  database. Output equations are responsive  to the  result information to control output settings  for  the apparatus.  The protection result information  is  available to  the automation logic equations but can only be  changed by  the protection logic equations. This is vice versa  for the  automation result  information.  Both  protection  and automation   sections have  access   to   certain   system information  in  the database, such as voltage  and  current quantities.
Patent NZ-515374-A (NZ)
Title: Remedies or prophylactics for diseases in association with chemokines
Inventor: SHIOTA TATSUKI
IPC: A61K31/455
Filed: 2000-05-18
Abstract: Remedies or prophylactics for diseases in association with chemokines such as MIP-1 alpha and/or MCP-1 are disclosed, wherein the remedies or prophylactics for diseases in association with the chemokines such as nephritis or nephropathy include the diseases such as glomerulonephritis, intestinal nephritis, nephrotic syndrome and demyelinating disease like multiple sclerosis. These remedies or prophylactics contain as the active ingredient, cyclic amine derivatives represented by the following formula (I), pharmaceutically acceptable acid addition salts thereof or pharmaceutically acceptable C1-C6 alkyl addition salts thereof.
Patent NZ-516470-A (NZ)
Title: Preserving a hemoglobin blood substitute with a transparent overwrap
Inventor: GAWRYL MARIA S
IPC: B32B15/08
Filed: 2000-07-07
Abstract: The invention relates to a method for preserving a packaged deoxygenated haemoglobin blood substitute comprising maintaining the deoxygenated haemoglobin in an oxygen barrier film overwrap package, wherein the package comprises transparent laminate material comprising an oxygen barrier layer and a polyolefin layer, wherein the laminate has a thickness of between about 0.0254 and 0.254 millimetres, and an oxygen permeability of less than about 0.01 cubic centimetres per 645 square centimetres over 24 hours at one atmosphere and at about 23°C, wherein the oxygen barrier layer comprises ethylene vinyl alcohol.
Patent NZ-522553-A (NZ)
Title: Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
Inventor: MERCEP MLADEN
IPC: C07D495/04
Filed: 2001-05-16
Abstract: Disclosed are dibenzoazulene derivatives of formula I, wherein: X is CH2, a heteroatom or NR13, R1, R5, R7, R8 and R9 are hydrogen, R2, R3 and R4 are independently H, halogen, alkyl, halomethyl, alkoxy, or alkylthio, R6 is H or halogen, R10 is -CHO, hydroxyalkyls, alkylamine or -(CH2)n-A wherein A is a heterocyclic ring. The derivatives are used in the manufacture of medicaments for the treatment of conditions induced by excessive unregulated production of cytokines or inflammation mediators.
Patent NZ-522950-A (NZ)
Title: Unit dose blister package with keyhole opening
Inventor: COLE-BENNETT BEVERLY LYNETTE
IPC: B65D75/34
Filed: 2001-05-08
Abstract: A child-resistant blister package (20) for unit dose products, e.g., medicaments, composed of a blister layer and a cover layer.  The blister layer is formed of a planar material, e.g., thermoformable or cold-formable webstock, and has plural intersecting perforated lines (32) to form plural cells (22) contiguous with the perforated lines.  Some or all of the cells of the blister layer have a peripheral planar flanged portion and a blister portion projecting from the flanged portion to form a cavity (26) in which the unit dose product is located.  The cover layer (28) is formed of a planar material, e.g., aluminum or other metal foil in either a single layer or laminated, and has plural intersecting perforated lines to form plural cells contiguous with those perforated lines.  Each cell of the cover layer is the same shape and size as a corresponding cell of the blister layer.  The cover layer is fixedly, e.g., adhesively, secured to the blister layer along the flanged portions, with the perforated lines of each being aligned and with the cells of the cover layer being coincident with the cells of the blister layer.  A keyhole shaped opening (40) is provided in each cell having a cavity of the blister layer.  Each keyhole shaped opening includes an elongated, e.g., 3 mm linear, slit (42) having a pair of ends , and a hole (48), e.g., a 1 mm circular hole, at a first one (46) of the pair of ends of the slit.  Each keyhole shaped opening is located in its associated cell of the blister layer so that the first one of the ends of its slit is located adjacent but spaced by a small gap (50) of a predetermined length, e.g., 1 mm, slightly from a perforated line forming an edge of the cell.  The hole of each keyhole shaped opening is directed to but spaced, e.g., 4 mm, from the cavity of the associated cell.
Patent NZ-524298-A (NZ)
Title: Fungicidal triazolopyrimidine formulations
Inventor: AVEN MICHAEL
IPC: C07D487/04
Filed: 2001-08-24
Abstract: An aqueous suspension concentrate fungicidal formulation for application to plants comprising at least one triazolopyrimidine of formula (I) is disclosed, wherein R1 and R2 independently denote hydrogen or C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, or C4-C10-alkadienyl, C3-C10-cycloalkyl, phenyl, naphthyl, or 5-or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5-or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or where R1 and R2 radicals may be unsubstituted or may carry one to three groups Ra, wherein Ra is cyano, nitro, hydroxyl, C1-C6-alkyl, C1-C6-halo- alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-alkylamino, di-C1-C6-alkylamino, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkynyl, C3-C6-alkynyloxy and C1-C4-alkylene- dioxy; or R1 and R2 together with the interjacent nitrogen atom represent a 5-or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted by one to three Ra radicals; R3 represents halogen or C1-C6-alkyl or C1-C6-alkoxy ; n represents an integer from 0 to 5 ; and Hal represents halogen together with one or more adjuvants selected from a) non-ionic water-soluble mixed polyalkoxylated aliphatic alcohol surfactants which is a random or block oligomer of formula: H2n+1Cn-O-(CH2CH2O)x(CH2CH(CH3)O)yH wherein: n is an integer from 8 to 18; x is an integer from 3 to 10 ; y is an integer from 1 to 3; and b) non-ionic water soluble ethoxylated aliphatic alcohol surfactants, the adjuvant is present in an amount sufficient to provide a ratio of the compound of formula (I) to adjuvant at 100: 75 to 100: 100.000 in the applied formulation. Adjuvants selected from non/ionic water/soluble mixed polyalkoxy-lated aliphatic alcohol surfactants, non-ionic water soluble ethoxylated aliphatic alcohol surfactants, amine ethoxylates, and micronized polymeric waxes enhance the efficacy of fungicidal triazolopzrimidines of structural formula (I). They can be incorporated into formulations of the fungicidal compounds or be added to spray mixtures (tank mix) as separately formualted additives in order to improve the efficacy and spectrum of these fungicides. Also disclosed are fungicidal compositions of the triazolopzrimidines and adjuvants, as well as methods for their use in the control of photopathogenic fungi.
Patent NZ-531980-A (NZ)
Title: Pharmaceutical compositions comprising epitopes of the UL47 gene or protein ( encodes VP13/14 ) for the treatment and prevention of herpes simplex virus ( HSV ) and methods of producing immune cells
Inventor: KOELLE DAVID M
IPC: A61K35/12
Filed: 2000-09-28
Abstract: A pharmaceutical composition comprises a herpes simplex virus (HSV) polypeptide and a pharmaceutically acceptable carrier. The polypeptide is an UL47 protein or fragment comprising amino acids 289-298, 548-557, 550-559, 551-559 and/or 551-561 or UL47. Also described is a polynucleotide that encodes a polypeptide of less than 100 amino acids in length comprising those amino acids and compositions comprising the polynucleotide. The polypeptide or an antigen presenting cell modified to present an epitope comprising amino acids 289-298, 548-557, 550-559, 551-559 and/or 551-561 or UL47 can be used for treating or preventing HSV infection. Also described are methods of producing immune cells directed against HSV and methods for identifying HSV epitope immunogenic for CD8+ T cells. (62) Divided out of 517959
Patent NZ-533038-A (NZ)
Title: Thioether substituted imidazoquinolines
Inventor: BONK JASON DANIEL
IPC: A61P31/02
Filed: 2002-06-07
Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position and are useful as immune response modifiers, are disclosed. The disclosed compounds and compositions can induce biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
Patent NZ-536512-A (NZ)
Title: 3-heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides
Inventor: WAGNER OLIVER
IPC: C07D417/04
Filed: 2003-04-22
Abstract: 3-heteroaryl substituted isoxazolines of formula (I), or to their salts that can be used for agricultural purposes. Methods and intermediate products for the production of said compounds, in addition to the use thereof or of agents containing the compounds for controlling undesired plants are also disclosed.
Patent NZ-540811-A (NZ)
Title: Use of HPV 16 and HPV 18 VLPs in the prevention of infection or disease caused by one or more of the group of oncogenic HPV types excluding types 16 and 18
Inventor: DUBIN GARY
IPC: C07K14/025
Filed: 2003-12-18
Abstract: Disclosed is the use of a mixture comprising HPV 16 and HPV 18 VLPs in the prevention of infection or disease caused by one or more of the group of oncogenic HPV types, excluding types 16 and 18.
Patent NZ-547619-A (NZ)
Title: Injectable sustained release implant having a bioerodible matrix core and a bioerodible skin
Inventor: CHOU KANG-JYE
IPC: A61K9/00
Filed: 2004-10-26
Abstract: Provided is a drug delivery device shaped and sized for injection in a needle or cannula ranging in size from 30 gauge to 15 gauge, comprising: a core including one or more drugs; and a polymeric skin at least partially, but not completely surrounding the core, the skin comprising a fIrst one or more polymers, impermeable to the passage of drug; wherein the device provides sustained release of the one or more drugs when exposed to a biological medium. Further provided are devices with specified polymers and drugs.
Patent NZ-556009-A (NZ)
Title: Nanoparticulate benzothiophene formulations
Inventor: LIVERSIDGE GARY
Filed: 2005-12-02
Abstract: Disclosed is a stable nanoparticulate benzothiophene composition comprising: a) particles of a benzothiophene or a salt thereof having an effective average particle size of less than 2000 nm; and b) at least one surface stabilizer, wherein the bezothiophene is raloxifene hydrochloride. Use of the above compostion in the manufacture of a medicament for treating or preventing osteoporosis or for treating breast cancer or other tumours of the breast and lymph nodular tissues.
Patent NZ-556246-A (NZ)
Title: Void forming and suspension system for a structural concrete slab
Inventor: FULLARTON MICK
Filed: 2007-07-02
Abstract: Void forming system 10 consists of void forming elements 12, 16 arranged over a ground surface 22 and acts as an interface between surface 22 and a concrete slab (not shown). Cavities are provided extending in the direction from surface 22 to the concrete slab.