baber/WOPTO huggingface dataset:
Patent CN-100562393-C (CN)
Title: 龙门刨床自动刀架
Inventor: JINHANG DANG
IPC: B23D7/06
Filed: 2007-12-30
Granted: 2009-11-25
Abstract: 一种结构简单，而且很容易实现机床的自动化的龙门刨床自动刀架，包括刀夹部件、小溜板、转盘、大溜板、刨床横梁，刀夹部件与后方的小溜板为固定连接，小溜板安装在后方的转盘上，小溜板与转盘上下滑动连接，转盘安装在大溜板上，转盘与后方的大溜板为在竖直面内相对旋转连接，大溜板安装在刨床横梁上并与之左右滑动连接，该龙门刨床自动刀架还包括变速马达、小溜板上下滑动驱动装置；变速马达固装在大溜板上端，变速马达的输出轴通过小溜板上下滑动驱动装置与小溜板连接。
Patent CN-100548333-C (CN)
Title: 一种具有改善睡眠功能的保健茶
Inventor: GENG LIN
IPC: A61K36/752
Filed: 2007-07-23
Granted: 2009-10-14
Abstract: 本发明涉及“一种具有改善睡眠功能的保健茶”，属于保健食品领域。一种具有改善睡眠功能的保健茶，由大枣和酸枣仁的乙醇提取物与刺五加蕊叶炒制而成。本发明将大枣和酸枣仁两味原料提取得到的浸膏粉碎后溶于水中制成水溶液，借助于叶面施肥的方法喷在刺五加植株上，一周后采摘刺五加蕊叶，炒制成茶。许多适宜人群在试饮用本发明的茶后普遍反应头脑清醒，感觉轻松，身体疲劳得到缓解，睡眠状况得到改善，大部分都摆脱了多年相伴的安眠药。临床验证，本发明保健茶除了具有改善睡眠之功效以外，还能平衡血压、缓解体力疲劳、延缓衰老、降低头痛之发生率、增加记忆力、有的人还具有增加工作强度的作用。饮用该茶无任何毒副作用和不良反应。
Patent CN-100550866-C (CN)
Title: 一种恢复边界网关协议连接的方法、装置及通信系统
Inventor: TAO WANG
IPC: H04L45/28
Filed: 2007-08-06
Granted: 2009-10-14
Abstract: 本发明提供了一种恢复边界网关协议连接的方法、装置及通信系统，其中，该通信系统包括多个不同自治系统的路由器，多个路由器之间通过BGP的TCP连接，其特征在于，路由器进一步包括：一主动建链模块，用于当发现与其连接的另一端路由器的链路断开时，向该端路由器发送建链请求，在收到该端路由器发来的查询消息后，返回TCP复位报文，使该端路由器复位TCP连接；一被动建链模块，用于在收到与其连接的另一端路由器发起的建链请求后，当本端与该端路由器的链路仍然存在时，拒绝建链请求，并发送查询消息至该端路由器，确认两端用户之间的链路是否正常，在收到该端路由器返回的TCP复位报文后，复位本端路由器的TCP连接。
Patent CN-100468474-C (CN)
Inventor: ZHENCAI ZHU
IPC: G01M17/00
Filed: 2007-09-14
Granted: 2009-03-11
Abstract: 斜井人车制动性能检测方法与装置由上位机系统(7)和下位机系统(6)组成；上位机系统(7)由便携式微机(4)和上位机无线通讯模块(5)组成，下位机系统(6)由加速度传感器(1)、单片机系统(2)和下位机无线通讯模块(3)组成，上位机系统(7)和下位机系统(6)通过无线通讯模块进行无线通讯；该方法利用由加速度传感器(1)、单片机(2)和下位机无线通讯模块(3)组成的下位机系统(6)检测斜井人车制动过程中的制动减速度，下位机系统(6)将测出的制动减速度通过无线通讯的方式由下位机无线通讯模块(3)发送给上位机系统(7)，由上位机系统(7)显示出制动减速度曲线，分析计算出平均制动减速度和空行程时间。
Patent CN-100582058-C (CN)
Title: 氧化铝陶瓷的微波辅助连接方法
Inventor: JIACHEN LIU
IPC: C04B37/00
Filed: 2008-05-05
Granted: 2010-01-20
Abstract: 本发明公开了一种氧化铝陶瓷的微波辅助连接方法，步骤为：(1)制备中间相：原料及质量百分比含量为Al-Si合金粉20.55～22.15wt%，Al 2 O 3  28.63～30.80wt%，ZrO 2  25～30wt%，SiO 2  19.32～20.80wt%，Y 2 O 3  1.25～1.5wt%；(2)制成膏状料粉；(3)将膏状中间相涂覆在待连接面上；(4)进行埋烧；(5)微波处理；(6)于微波炉中开放环境下氧化处理。本发明提供了一种低熔点、充分润湿陶瓷表面、采用微波局部加热、氧化气氛下先连接后反应、并形成耐高温、耐磨、耐腐蚀的低温快速连接氧化铝陶瓷的微波辅助连接方法。应用于高速输送的物料对管道产生严重冲刷和磨损的环境中，也用于航空航天发动机、核工业等耐高温、耐腐蚀的大异形氧化铝基陶瓷构件的连接。
Patent CN-100572814-C (CN)
Title: 配流盘改进了的双作用叶片泵及其制造方法
Inventor: SHENGMING LUO
IPC: F04C14/10
Filed: 2008-01-25
Granted: 2009-12-23
Abstract: 配流盘改进了的双作用叶片泵，包括一壳体，其内为一偏心油腔，在该油腔内设有带叶片的转子，一传动轴带动该转子在偏心油腔内旋转，油腔顶部设有配流盘，配流盘对应于偏心油腔的最大容积部分开有吸油槽孔，对应于偏心油腔的最小容积部分开有排油槽孔，配流盘采用粉末烧结合金技术制成。采用粉末烧结合金制成的配流盘有利于批量生产，模具的使用寿命远远长于现有技术。现有技术中的模具冲压三千次左右就要修整，而采用粉末烧结合金，模具可以压出几万个配流盘而不损坏。由于按照本发明的配流盘是通过粉末烧结制成，粉末冶金内部有小孔，可以洗油，所以，按照本发明的双作用叶片泵的配流盘的耐磨性大大提高，其使用寿命提高了一倍左右。
Patent MX-7357-E (MX)
Inventor: JONCKERS KEES
IPC: C07C239/00
Filed: 1985-03-15
Abstract: A process for the preparation of urea in which a carbamate- and free ammonia-containing urea synthesis solution is formed from carbon dioxide and excess ammonia in a synthesis zone at a pressure of 125-350 bar, at least a portion of the carbamate present in the urea synthesis solution is decomposed in a stripping zone at the pressure of the synthesis zone or at lower pressure by heat supply and countercurrent contact with a stripping gas, the carbamate decomposition products, together with a portion of the excess ammonia and the stripping gas, are removed from the stripping zone as a gas mixture, at least a portion of the gas mixture obtained is condensed in a condensation zone and the stripped urea synthesis solution is processed into a urea solution or solid urea. The process is characterized in that in the condensation zone also at least 30% of the equilibrium amount of urea achievable under the reaction conditions is allowed to form and the carbamate- and urea-containing mixture is supplied to the synthesis zone. By preference, urea formation is continued until 50-80 %, of the way to the equilibrium has been covered.
Patent PT-1134116-E (PT)
Inventor: JESUS GONZALEZ GARCIA
IPC: B60N3/00
Filed: 2000-06-08
Abstract: SHELF FOR THE BACK PART OF THE BACKREST IN A VEHICLE, of the type basically made up of two molded material parts, consisting in a fixed part corresponding to the support (1) that secures the shelf and is attached to the frame of the seat (3), and the shelf (2) itself, which is mounted on the support (1), so that two stable positions are adopted, one unfolded to be used and in other in the closed position. It is characterized by the fact that an opening in the shelf (2) has been provided by means of sliding two axles (4, 5), located on the sides of the support (1), which are received inside lateral grooves (6) in the form of runners, provided for such purpose in the shelf (2) that when the shelf (2) is pulled down to the bottom of the runners (6) it turns around the axles until it becomes placed in the horizontal position. Stability in this position is obtained by means of a butt (7) arranged on the support (1) and a side support (8) located at the same level as the axles. <IMAGE>   <IMAGE>
Patent PT-1159617-E (PT)
Inventor: FLOHE LEOPOLD
IPC: G01N33/573
Filed: 2000-03-06
Abstract: The invention relates to a method to detect male antifertility problems based on the determination of latent phospholipid hydroperoxide glutathione peroxidase (PHGPx).
Patent PT-1200088-E (PT)
Inventor: VITANYI-NEE-MORVAI MAGDOLNA
IPC: A61K31/47
Filed: 2000-07-28
Abstract: The invention relates to a stable, solid pharmaceutical composition comprising as active ingredients paracetamol and drotaverine hydrochloride in a mixture with one or more organic acid or potassium sorbate as stabilizers, one or more usually used pharmaceutical auxiliary materials and optionally additional active ingredient. As additional active ingredient codein phosphate may be used.
Patent PT-1320712-E (PT)
Title: Multi-purpose microchannel micro-component
Inventor: SEABA JAMES
IPC: C01B3/38
Filed: 2001-07-23
Abstract: A method for processing separate fluid flows in a micro component system for the production of hydrogen gas used in fuel cells in which a first fluid flow is directed to micro channels formed on one side of a conductive separator maintained in an enclosure, a second fluid flow is directed to micro channels formed on the opposite side of the separator, and laminar flow is maintained in the fluids such that heat transfer between the fluids on the opposite sides of the micro channels is by conduction through the separator and heat transfer within the fluids on the opposite sides of the micro channels is predominantly by convection within the fluids.
Patent PT-1178037-E (PT)
Inventor: GERUSZ VINCENT
IPC: C07D285/08
Filed: 2001-08-02
Abstract: The invention provides fungicidal compounds of formula I and salts thereof: <CHEM>  wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method for combating fungi which comprises applying these.
Patent PT-1345684-E (PT)
Title: Improvements to oxidising processes by oxygen transfer within a liquid medium in a reactor under pressure
Inventor: CAMPO PHILIPPE
IPC: C02F1/00
Filed: 2001-12-18
Abstract: Methods for oxidizing a liquid with an oxidization gas in a closed volume reactor. A feed liquid which contains compounds to be oxidized is fed into the closed volume reactor, and a feed gas containing oxygen is fed into the reactor so as to form a gas overhead above the feed liquid. The overhead is later purged at a specific rate so as to ensure a predetermined oxygen partial pressure is maintained in the gas overhead. The value of this partial pressure corresponds to a predetermined, desired rate of oxidation of the compounds contained in the feed liquid.
Patent PT-1413323-E (PT)
Title: Glass as sintering aid, open-pore shaped article and method for its production
Inventor: BERGER GEORG
IPC: A61L27/50
Filed: 2003-10-16
Abstract: Bone substitute material comprises 65-99.9 wt.% orthophosphates and 0.1-35 wt.% diphosphates and comprises 35-99.9 wt.% of a primary crystal phase consisting of calcium sodium and/or potassium orthophosphates, 0.1-20 wt.% of a secondary crystal phase consisting of disodium calcium diphosphate, dipotassium calcium diphosphate and/or dicalcium diphosphate, and 0.1-65 wt.% of an amorphous phase.  Bone substitute material comprises 65-99.9 wt.% orthophosphates and 0.1-35 wt.% diphosphates and comprises 35-99.9 wt.% of a primary crystal phase consisting of calcium sodium and/or potassium orthophosphates of formula (I), 0.1-20 wt.% of a secondary crystal phase consisting of disodium calcium diphosphate, dipotassium calcium diphosphate and/or dicalcium diphosphate, and 0.1-65 wt.% of an amorphous phase. Ca10KxNa1-x(PO4)7 (I)  x  =  0-1. Independent claims are also included for:  (1) a process for producing the bone substitute material;  (2) glass for use as a sintering aid for bioabsorbable calcium phosphate materials other than beta-tricalcium phosphate, having the following oxide composition (wt.%): silicon (73-78), magnesium (8-11), sodium (12-19), potassium (0-22), phosphorus (0-20).
Patent PT-1419973-E (PT)
Title: Collapsible pallet box
Inventor: BALLARIN CARLOS RIVERA
IPC: B65D19/18
Filed: 2003-11-13
Abstract: The box is characterised in that the lid (2) comprises a plurality of aligned cavities (6,7,8,9) in the vicinity of the large sides and containing, in their interior, retaining catches (42) for the laminar element (3) for lateral closure of the box and in that the lateral edges of the lid have lower projecting flanges (21,22) with retaining profiles and capable of engaging in opposing apertures (25,26) of the platform (1) while being retained by said retaining profiles, said platform (1) and lid (2) comprising respective engaging structures for forming a folded assembly in which the aforementioned flanges (21,22) of the lid (2) are introduced in corresponding apertures (25,26) of the platform (1). <IMAGE>
Patent PT-1537374-E (PT)
Title: Penetration-resistant material and articles made of the same
Inventor: BOETTGER CHRISTIAN KURT
IPC: D06M17/00
Filed: 2003-09-02
Abstract: A penetration-resistant material is described comprising at least a double layer of wowen fabric wherein the double layer comprises a first layer of fabric composed of a first set of threads comprising 3.5 to 20 threads/cm, having a linear density of at least 210 dtex, and comprising at least 65 % of the fabric weight, and a second set of threads comprising 0.5 to 16 threads/cm and having a linear density of at least 50 dtex, with the second set of threads being transverse to the first set of threads, and the ratio of the number of threads/cm of the first set to that of the second set is > 1, and a second layer of fabric composed of a first set of threads comprising 0.5 to 16 threads/cm and having a linear density of at least 50 dtex, and a second set of threads comprising 3.5 to 20 threads/cm, having a linear density of at least 210 dtex, and comprising at least 65 % of the fabric weight, with the second set of threads being transverse to the first set of threads, and the ratio of the number of threads/cm of the second set to that of the first set is > 1, and wherein the first and second sets of threads of the first layer have a parallel orientation towards the first and second sets, respectively, of threads of the second layer, and wherein in the first layer of fabric at least the first set of threads and in the second layer of fabric at least the second set of threads are treated with a water-repellant.
Patent PT-1616575-E (PT)
Title: Method for treating inflammation
Inventor: THOMPSON PENNY
IPC: C07K16/24
Filed: 2000-12-22
Abstract: There is provided an antibody or antibody fragment that binds to an IL-20 polypeptide selected from the group consisting of SEQ ID. NOs: 1, 2, 3 and 4 for use in the treatment of psoriasis, wherein the psoriasis is associated with a joint disease.
Patent PT-1639928-E (PT)
Title: Set of knives for an electric motor-operated food processor, and corresponding food processor
Inventor: HILGERS STEFAN
IPC: A47J43/07
Filed: 2003-03-12
Abstract: The blade set (10) has at least one blade (11,12), fitted to a mounting (16) at its centre and provided with 2 diametrically-opposing sickle-shaped end sections (13,14; 21,22), curved in opposite directions, with a cutting edge (18, 25) along the outer or inner edge of each end section. An independent claim for an electric food processor is also included.
Patent PT-2023070-E (PT)
Title: Regenerative heat exchanger and radial seal for use for such and method for separating gaseous media in a regenerative heat exchanger
Inventor: HALBE VOLKER
IPC: F28D19/04
Filed: 2007-07-24
Abstract: The heat exchanger has a rotor (10) comprising a set of radially running sector walls (12). Heat accumulator chambers (19) are arranged one behind the other in a radial direction of the rotor and through-flowable by a gaseous medium. The chambers comprise openings formed in an area of front surfaces of the rotor, and a radial seal (20) is arranged at the front surfaces of the rotor, where the seal and the rotor are rotatable relative to each other. The radial seal is designed in such a manner that the seal partially covers the opening during the operation of the heat exchanger. An independent claim is also included for a method for separating gaseous medium in a regenerative-heat exchanger.
Patent PT-1990281-E (PT)
Title: Method and device for sealing a rip-off film to a packaging element
Inventor: NAROSKA MARCUS
IPC: B29C65/18
Filed: 2008-04-24
Abstract: The method involves transporting a packaging element (12). The packaging element is moved by a sealing stroke transverse to a transportation direction (A) towards a stamp tool (28), which carries a tear-off foil, and is pressed at the foil. The packaging element is heated to a temperature required for subsequent sealing by a non-contact manner by a heating device (24) e.g. thermal radiator. The foil and the element are sealed together under the effect of heat. The tool is moved towards the element by a feed stroke executed counter to the sealing stroke during sealing. An independent claim is also included for a device for sealing a packaging element using a tear-off foil, comprising a conveyor device.
Patent PT-2197964-E (PT)
Title: Pigment-free aqueous polymeric dispersions labelled with fluorescent dyes, production of said polymer dispersions and their use
Inventor: KOPLIN TOBIAS JOACHIM
IPC: C08J3/00
Filed: 2008-09-11
Abstract: Pigment-free, aqueous polymer dispersion marked with fluorescent dyes, having a viscosity of from 500 to 900 mPa·s, determined with the aid of the Brookfield method (spindle 3, 23° C.), and comprising, based in each case on the solids of the polymer dispersion, (A) from 1 to 99% by weight of at least one type of water-soluble and/or water-dispersible polymer, (B) from 1 to 20% by weight of at least one type of water-dispersible polymer particles which comprise at least one fluorescent dye and (C) from 0.001 to 3% by weight of at least one thickener; process for its preparation and its use.
Patent PT-640077-E (PT)
Inventor: HUTCHINSON DOUGLAS K
IPC: A61K31/551
Filed: 1993-04-21
Abstract: A compound of structural Formula I:   <IMAGE>  +TRthereof wherein: each n is independently 1 to 3; Y is chosen from a-n as defined herein; wherein each occurrence of said C1-6 alkyl may be substituted with one or more F, Cl, Br, I, OR1, CO2R1, CN, SR1, or R1 (where R1 is a hydrogen or C1-4 alkyl); X and Z are independently C1-6 alkyl, C3-12 cycloalkyl or hydrogen, or X and Z form a C0-3 bridging group, preferably X and Z are hydrogen; U, V and W are independently C1-6 alkyl, F, Cl, Br, hydrogen or a C1-6 alkyl substituted with one or more of F, Cl, Br or I, preferably U and V are F and W is hydrogen; R is hydrogen, C1-12 alkyl, C3-12 cycloalkyl, C1-6 alkoxy, C1-6 alkyl substituted with one or more F, Cl, Br, I or OH; and q is 0 to 4 inclusive. Oxazolidinone derivatives possessing a substituted diazine moiety bonded to the N-aryl ring are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.
Patent PT-635359-E (PT)
Inventor: ALPEN ULRICH VON
IPC: B32B17/10
Filed: 1994-07-19
Abstract: The invention relates to armoured glass, in particular for motor vehicles, consisting of several sheets of silicate glass joined to each other via interlayers of thermoplastic polymer and of a film or sheet of impact-resistant plastic which is applied with the aid of a layer of thermoplastic adhesive to that surface of the armoured glass which is facing towards the passenger compartment in the installed state and which is provided on its free surface with a scratch-resistant coating, a sheet of silicate glass (1; 14; 17), placed in front of the film or sheet (6) of impact-resistant plastic towards the outside, being provided with a layer (10, 15, 20) which reflects thermal radiation. <IMAGE>
Patent PT-673937-E (PT)
Inventor: YOSHINO HIROSHI
IPC: C07D401/12
Filed: 1994-09-08
Abstract: Novel bicyclic heterocyclic sulfonamide and sulfonic ester derivatives represented by general formula (I) having an antitumor activity and a reduced toxicity, pharmacologically acceptable salts thereof, and a process for producing the same; wherein ring A represents an optionally substituted mono- or bicyclic aromatic group; ring B represents an optionally substituted 6-membered unsaturated hydrocarbon ring or 6-membered unsaturated heterocyclic group containing one nitrogen atom; ring C represents an optionally substituted 5-membered heterocyclic group containing one or two nitrogen atoms; W represents a single bond or -CH=CH-; X represents -NR<1>- or oxygen; Y represents carbon or nitrogen; Z represents -NR<2>- or nitrogen; and R<1> and R<2> represent each independently hydrogen or lower alkyl. <CHEM>
Patent PT-764758-E (PT)
Inventor: STEPHAN HORMANN DIPL PHYS
IPC: E05F15/00
Filed: 1996-08-26
Abstract: The roller shutter is guided between two upright guide rails and has a roller at the top to roll and unroll the shutter. The light gate is positioned across the outside of the shutter as well as over the inside to monitor obstructions eg. hands. The security and safety system shuts off the servo motor when an obstruction is identified. The light gate uses one light beam, or one IR beam. The light source (8) is in one rail, with the detector (9) in the same rail but on the other side of the shutter. The other rail has two plane reflecting mirrors to turn the beam back over the other side of the shutter.
Patent PT-823174-E (PT)
Inventor: LANGE MARTIN KLAAS DE
IPC: H04M1/00
Filed: 1996-04-26
Abstract: The invention provides a device (1) for providing a transparent exchange of commands and data between an IC card (11) and a remote terminal (42) via a communication network (41). The device (1) acoustically couples the IC card (11) with a telephone set (43). In order to speed up the exchange of data and commands, the device (1) preferably utilizes high level commands which represent several low level card commands. However, low level commands may also be transparantly passed as a special high level command. The device (1) is inexpensive but allows an efficient use of IC cards for e.g. payment and identification purposes. <IMAGE>
Patent PT-837066-E (PT)
Inventor: TAKAHASHI SATORU
IPC: C07D499/46
Filed: 1996-06-13
Abstract: A novel process for producing a penicillin G phenyl ester of the formula: <CHEM> or a salt thereof which comprises reacting a compound of the formula:   <CHEM>  or a salt thereof with a compound of the formula: <CHEM> or a salt thereof.o
Patent PT-857167-E (PT)
Inventor: ISAKSEN JAN BIRGER
IPC: C05C5/02
Filed: 1996-10-18
Abstract: The invention relates to a method for making NK-fertilizers basically from calcium nitrate fertilizers and potassium nitrate and homogeneous NK-fertilizer products. Calcium nitrate fertilizer is melted together with potassium nitrate to form a melt or suspension thereof which is particulated to form a homogeneous NK-fertilizer. The calcium nitrate fertilizer and the potassium nitrate are melted at 90-120° C. and then heated to the desired particulation temperature being 160-190° C. for prilling and 90-140° C. for granulation. The components are mixed in ratios giving a melt or suspension comprising 40-14 weight % calcium nitrate, 55-85 weight % potassium nitrate, 0.5-6 weight % water, 0-4 weight % ammonium nitrate and 0-5 weight % magnesium nitrate.
Patent PT-889853-E (PT)
Inventor: MAUNUKSELA JYRI JOHANNES
IPC: C02F1/50
Filed: 1997-03-18
Abstract: PCT No. PCT/FI97/00175 Sec. 371 Date Apr. 20, 1999 Sec. 102(e) Date Apr. 20, 1999 PCT Filed Mar. 28, 1997 PCT Pub. No. WO97/34833 PCT Pub. Date Sep. 25, 1997Waste water in an activated sludge waste treatment plant is treated with a quantity of peracetic acid which destroys harmful filamentous microorganisms while preserving the beneficial microorganisms used in the purification procedure.
Patent PT-912707-E (PT)
Inventor: VELTMAN JEROME J
IPC: C11D1/14
Filed: 1997-05-15
Abstract: A toilet cleansing block contains anionic surfactant such as a sulfonate, linear primary alcohol such as Neodol 23, and binder such as hydroxy ethyl cellulose. The block erodes very slowly, yet at essentially identical rates in hard or soft water. The block is for immersion in toilet tanks.
Patent PT-914236-E (PT)
Inventor: JONKKA ARVO
IPC: B27L11/00
Filed: 1997-07-01
Abstract: PCT No. PCT/FI97/00425 Sec. 371 Date Jan. 6, 1999 Sec. 102(e) Date Jan. 6, 1999 PCT Filed Jul. 1, 1997 PCT Pub. No. WO98/01272 PCT Pub. Date Jan. 15, 1998The invention concerns a knife disc arrangement of a disc chipper, said arrangement comprising a rotating knife disc (1), knives (3), wear plates (4) and supporting strips (11) supporting the wear plates. The invention also concerns a hinge strip acting as a supporting strip (11) for the wear plate. The knives are supported against the direction of rotation of the disc by fitting the base edge (9) of the knife against a supporting surface (10). The supporting surface (10) supporting the base edge of the knife (3) is located in the supporting strip (11).
Patent PT-951553-E (PT)
Inventor: BRANTON PHILIP E
IPC: A61P35/00
Filed: 1997-07-03
Abstract: The present invention relates to a pharmaceutical agent for induction of apoptosis for the treatment of human diseases which involve inappropriate cell survival, which includes adenovirus E4orf4, an analog or a biologically active fragment thereof and/or adenovirus E4orf6, an analog or a biologically active fragment thereof. There is also provided a pharmaceutical composition for the treatment of human diseases which involve inappropriate cell survival, which comprises a therapeutic amount of adenovirus E4orf4, an analog or a biologically active fragment thereof and/or adenovirus E4orf6, an analog or a biologically active fragment thereof in association with a pharmaceutical carrier. Included in the invention are methods for identifying compounds as analogs of the adenovirus E4 death proteins.
Patent PT-998495-E (PT)
Title: Amyloid beta protein (globular assembly and uses thereof)
Inventor: KRAFFT GRANT A
IPC: C12Q1/02
Filed: 1998-02-05
Abstract: The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid ² protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity,  inter alia  in the treatment of learning and/or memory disorders.
Patent PT-981520-E (PT)
Inventor: TILLYER RICHARD D
IPC: C07C215/68
Filed: 1998-05-12
Abstract: An efficient method for the preparation of key intermediate, in the synthesis of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one, a reverse transcriptase inhibitor is achieved using a chiral addition reaction to the 4-chloro-2-trifluoromethylketoaniline with an organozinc complex to give the desired alcohol. This instant method has broad applicability in the chiral addition to any prochiral ketone.