Patent SG-11201908201Q-A (SG)
Title: In-body perfusion system
Inventor: ANDRETTA CARLO
IPC: A61M1/34
Filed: 2018-05-02
Abstract: 1 1-1 N N O N 00 O 1-1 N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT °Ens ono o Hololiolomioomliflo ow (10) International Publication Number WO 2018/202671 Al (51) International Patent Classification: A61F 2/02 (2006.01) A61M 5/172 (2006.01) A61M 1/34 (2006.01) C12N 5/071 (2010.01) A61M 1/36 (2006.01) (21) International Application Number: PCT/EP2018/061127 (22) International Filing Date: 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17169158.7 02 May 2017 (02.05.2017) EP (72) Inventor; and (71) Applicant: ANDRETTA, Carlo [CH/CH]; Eichstrasse 4, CH-8142 Uitikon-Waldegg (CH). (74) Agent: SCHMAUDER & PARTNER AG; Zwangiweg 7, CH-8038 Ziirich (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: IN-BODY PERFUSION SYSTEM A V Fig. 2 (57) : An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises a perfusion chamber (16) containing a load of biologically active cells and is provided with a fluid entrance (18), a fluid exit (20) and a chamber volume (22) formed therebetween. The fluid entrance comprises at least one first microchannel platelet (24) and the fluid exit comprises at least one second microchannel platelet (26), each one of the microchannel platelets comprising at least one array of microchannels (28) defining a fluid passage between respective external and internal platelet faces, the microchannels having an opening of 0.2 to 10 1.1m. The fluid entrance (18) of the perfusion chamber is in fluid communication with the inlet section (12) of the transmission line; and the flow restriction element (10) is configured to establish a predetermined pressure excess in the inlet section (12) versus the outlet section (14). [Continued on next page] WO 2018/202671 Al IMEDIMOMMIDIREI0100101011010HIMMOIIMEMOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))