Patent EA-004237-B1 (EA)
Title: Method, device and catheter for in vitro determining blood properties such as blood viscosity
Inventor: POP GHEORGHE AUREL MARIE
IPC: A61B5/296
Filed: 2000-06-05
Abstract: 1. Method for determining properties of blood, such as the blood viscosity of a person, comprising of generating in vivo for a determined time, by means of an electrical alternating current of a determined frequency, a measurement signal of the impedance of the blood between at least two points centrally in a blood volume, wherein the measurement signal is processed such that variations therein with a frequency in the order of magnitude of the heart frequency are substantially absent therefrom, and comparing the processed measurement signal with predetermined relations between impedance and the properties of the blood, such as the viscosity. 2. Method as claimed in claim 1, characterized in that an ECG signal is recorded in a cavity containing the blood volume, and processing of the measurement signal takes place by considering only measurement values in the same phase each time of the ECG signal. 3. Method as claimed in either of the foregoing claims, wherein a blood viscosity-reducing agent is administered to the person in a dosage such that the measured impedance is adjusted to a predetermined value. 4. Method as claimed in claim 1 or 2, wherein the distance between the at least two points is a small fraction of the distance of these points to a boundary of the blood volume. 5. Method as claimed in claim 1, characterized in that a central location in the right-hand atrium of the heart is selected for the at least two points centrally in a blood volume. 6. Device for determining determined blood properties, such as the blood viscosity of a person, comprising a catheter, which comprises at least two electrode systems close to a distal end and connecting lines extending from the electrode systems to the proximal end of the catheter, and further executed such that in use the electrode systems will be positioned centrally in a blood volume, a measuring device which is connectable to the connecting lines and which is embodied such that it can generate a measurement signal of the impedance between the electrode systems, and a processing device which is embodied such that it processes the measurement signal such that variations therein with a frequency in the order of magnitude of the heart frequency are substantially absent therefrom. 7. Device as claimed in claim 6, characterized in that the measuring device generates an ECG signal and that the processing device records measurement signals in each case during at least one determined phase of the ECG signal. 8. Device as claimed in claim 7, characterized in that the determined phase corresponds with the occurrence of the maximal and/or the minimal impedance. 9. Device as claimed in any of the claims 5-8, characterized in that the at least two electrode systems comprise at least two electrodes which are connectable to the alternating current and two measuring electrodes lying therebetween. 10. Device as claimed in any of the claims 5-9, characterized in that the electric alternating current is adjusted to a frequency between 4 and 2000 kHz. 11. Device as claimed in any of the claims 5-10, characterized in that the processing device is further adapted to determine a factor subject to the measured impedance, which factor is a measure for the tendency to thrombosis. 12. Device as claimed in any of the claims 5-11, characterized in that the processing device is further adapted to determine a factor subject to the measured impedance, which factor indicates the inflammatory activity in atherosclerosis. 13. Device as claimed in any of the foregoing claims, characterized in that the impedance measurement is a resistance measurement and/or capacitance measurement and/or a phase difference measurement. 14. Device as claimed in any of the foregoing claims, characterized in that the measuring device is received in an implantable unit. 15. Device as claimed in any of the foregoing claims, characterized in that the measuring device is combined with an implantable heart pacemaker unit and is provided with two electrically separated circuits each having an individual power source, wherein the one circuit is adapted for the pacemaker function and the other circuit is adapted for the impedance measurement. 16. Device as claimed in any of the foregoing claims, characterized in that the catheter is embodied such that the at least two electrode systems for performing the impedance measurement can be placed in the right-hand atrium of the heart. 17. Device as claimed in any of the foregoing claims, characterized in that it comprises a catheter which is electrically connectable to the pacemaker unit with its proximal end and comprises one or more sensor electrodes and/or stimulating electrodes for the pacemaker function. 18. Device as claimed in claim 17, characterized in that the sensor electrodes and/or stimulating electrodes for the pacemaker function are arranged on the distal side relative to the electrode systems for the impedance measurement, that the outermost distal end of the catheter is intended for placing in the apex of the right-hand ventricle, and that the distance between the outermost distal end of the catheter and the electrode systems for the impedance measurement is such that, when the outermost distal end is placed in the apex of the right-hand ventricle, the electrode systems for the impedance measurement are situated centrally in the right-hand atrium. 19. Device as claimed in claim 17 or 18, characterized in that the electrode systems for the impedance measurement are arranged on a sheath round a core wire to the sensor electrodes and/or stimulating electrodes and that this sheath is slidable along the core wire. 20. Device as claimed in any of the foregoing claims, characterized in that it is adapted to enable remote read-out of the determined factors of thrombosis formation and/or of inflammatory activity and/or the measured impedance values. 21. Catheter for a device as claimed in any of the foregoing claims, characterized in that this catheter comprises an intravascular part with at least two electrode systems for an impedance measurement, is electrically connectable with one end to the pacemaker unit, and comprises one or more sensor electrodes and/or stimulating electrodes for the pacemaker function. 22. Catheter as claimed in claim 21, characterized in that the sensor electrodes and/or stimulating electrodes for the pacemaker function are arranged on the distal side relative to the electrode systems for the impedance measurement, that the outermost distal end of the catheter is intended for placing in the apex of the right-hand ventricle, and that the distance between the outermost distal end of the catheter and the electrode systems for the impedance measurement is such that, when the outermost distal end is placed in the apex of the right-hand ventricle, the electrode systems for the impedance measurement are situated in the right-hand atrium.