baber/WOPTO huggingface dataset:
Patent CA-2440593-A1 (CA)
Inventor: KOSKI RAYMOND A
IPC: C07K14/18
Filed: 2002-03-11
Abstract: Cette invention concerne des procédés et des compositions comprenant des polypeptides isolés et purifiés du virus West Nile et des fragments immunogènes de ceux-ci, des molécules d'acide nucléique les codant et des anticorps spécifiques de ces polypeptides ou fragments. Ces polypeptides et fragments, les protéines de fusion les comprenant et les anticorps sont utiles comme vaccins pour traiter, inhiber ou prévenir l'infection ou la maladie imputable au virus West Nile, pour détecter cette infection et surveiller la progression de la maladie ou de l'immunisation.
Patent CA-2444759-A1 (CA)
Inventor: POORE BERNARD BRANDT
IPC: H02K16/04
Filed: 2003-10-14
Abstract: A dual stator axial gap DC brushless machine is provided with first and second stators having equal pole counts, a given pole arc, and a given slot arc. A rotor is disposed between the first and second stators, having a pole count greater than the first and second stators. The pole count ratio between each stator and the rotor is six to eight. The second stator has a given degree of angular displacement relative to the first stator less than, 3/4, 1/2 or 1/2 the pole arc of the stators, but not less than the slot arc of the stators. Where the first and second stators each have a pole count of 18 and the rotor has a pole count of 24, the stator pole arc is 20 degrees, the rotor pole arc is 15 degrees, and the given degree of angular displacement is less than 20 degrees, 15 degrees, 10 degrees, or 5 degrees.
Patent CA-2446155-A1 (CA)
Title: 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
Inventor: BROWN WILLIAM
IPC: A61P1/10
Filed: 2002-05-16
Abstract: Compounds of general formula I: R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituent s selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprisingthe novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
Patent CA-2447799-A1 (CA)
Title: Emission ratiometric indicators of phosphorylation
Inventor: TSIEN ROGER Y
IPC: C12Q1/37
Filed: 2002-05-24
Abstract: A chimeric phosphorylation indicator is provided. A chimeric phosphorylation indicator can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. A chimeri c phosphorylation indicator also can contain a phosphorylatable polypeptide an d a fluorescent protein, wherein the phosphorylatable polypeptide is contained within the sequence of the fluorescent protein, or wherein the fluorescent protein is contained within the sequence of the phosphorylatable polypeptide . Also provided are polynucleotides encoding such chimeric phosphorylation indicators, as well as kits containing the indicators or the polynucleotides . In addition, a method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.
Patent CA-2448124-A1 (CA)
Inventor: TATEISHI TAKEYA
IPC: F02B63/00
Filed: 2001-09-04
Abstract: A work-assembling auxiliary device for carrying out the matching of phases in the spline-coupling of a main shaft Sm of a transmission T to a crankshaft Sc of an engine E includes an output shaft 40 radially movably connected through an Oldham coupling 41 to an input shaft 30 connected to and rotated by a drive source. A chamfer 61a is provided at a tip end of a socket 61 mounted on the output shaft 40, and in inserting the socket 61 into a socket hole h in a crank pulley Pc, the output shaft 40 is smoothly aligned with the crankshaft Sc by the action of the chamfer 61a. Further, when the output shaft 40 is reciprocally rotated, the phases of the socket 61 and the socket hole h are smoothly matched with each other, whereby the engagement of the socket 61 and the socket hole h is achieved.      Thus, even if a somewhat deviation exists between an axis of the crankshaft Sc of the engine E and an axis of the output shaft 40 of the work-assembling auxiliary device, the socket 61 of the output shaft 40 can be reliably engaged into the socket hole h in the crankshaft Sc.
Patent CA-2448913-A1 (CA)
Inventor: OLSEN GUNNAR M
IPC: A61P15/00
Filed: 2002-07-02
Abstract: The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Patent CA-2449357-A1 (CA)
Inventor: SUN NANSHENG
IPC: F28F9/013
Filed: 2003-11-13
Abstract: An improved support for a tube bundle of a nuclear steam generator has a pair of plates separated by spacers and holding slotted disc springs used to mount tubes through tube holes of the pair of plates. The slotted disc springs deform upon installation and substantially eliminate tube vibration during use, thereby extending the useful life of the tubes. At the same time, the springs limit the pressure drop between sides of the support and enhance the heat transfer from the tubes.
Patent CA-2451284-A1 (CA)
Inventor: MERRILL RICHARD P
IPC: F28D5/02
Filed: 2002-06-03
Abstract: An evaporative cooler (20) and method of operation is provided in which the cooler (20) includes a liquid distributor (22), a body (26) having a surface for receiving liquid from the distributor (22), an air moving device (28) fo r generating a flow of air over the surface of the body (26), a heat transfer working fluid conduit (32) having a surface arranged to receive substantiall y all of the liquid from the body (26) and a liquid recirculating mechanism (4 0) to recirculate the liquid from the conduit (32) surface to the body (26) surface. The body (26) occupies a plan area larger than the plan area occupi ed by the conduit (32), the conduit (32) being located outside the flow of air, and the velocity of liquid being increased after it leaves the body (26) and before it engages the conduit (32).
Patent CA-2454697-A1 (CA)
Inventor: DEVINE JOHN NEIL
IPC: H01M8/10
Filed: 2002-09-18
Abstract: L'invention concerne une cellule à combustible ou cellule électrolytique qui comprend un matériau polymère conducteur d'ions, lequel contient une première unité de répétition représentée par la formule (I): - (O-Ph?1¿-CO-Ph?1¿-O-Ph?1¿-CO-Ph?1¿) -, et une seconde unité de répétition représentée par la formule (II): - (O-Ph?2¿-O-Ph?3¿-CO-Ph?4¿) -, ou par la formule (III): (O-Ph?2¿-O-Ph?3¿-SO¿2?-Ph?4¿) -; dans lesquelles Ph?1¿, Ph?2¿, Ph?3¿ et Ph?4¿ représentent indépendamment des fractions phényle. La seconde unité de répétition comprend des sites d'échange d'ions. Ce matériau polymère peut également contenir une troisième unité de répétition qui est amorphe.
Patent CA-2458135-A1 (CA)
Inventor: DUNNE MICHAEL WILLIAM
IPC: A61P31/04
Filed: 2002-07-31
Abstract: La présente invention concerne une méthode permettant de traiter des infections respiratoires chez l'homme par administration d'une dose unique d'azithromycine.
Patent CA-2458522-A1 (CA)
Title: Induction drive for induction driven conveyor
Inventor: LEE RICK
IPC: B65G23/23
Filed: 2002-09-24
Abstract: Induction drives for either straight or curved conveyors as well as methods of driving endless conveyor belts. Pivotable magnets (310...) can be free floating in holders (330), or in other embodiments, each pivotable magnet (50...,190...,350...) can be interconnected serially with its previous and its subsequent magnet. Whether free floating or serially interconnected pivotable magnets (50...,190...,310...,350...) create the virtual continuous magnetic body (150...,290...,440...). When the virtual continuous magnetic body (150...,290...,440...) encounters the stator's electromagnetic field the resultant magnetic flux pushes the continuous magnetic body (150...,290...,440...) through the groove (40, 210, 230) of the conveyor bed (38, 112, 220). Each of the pivotable magnets (50...,190...,310...,350...) is dimensioned to not impede its previous magnet and its subsequent magnet, when the electromagnetic flux is reversed.
Patent CA-2460453-A1 (CA)
Title: Nebulizer apparatus and method
Inventor: GRYCHOWSKI JERRY R
IPC: A61M15/00
Filed: 1997-02-13
Abstract: An apparatus and method for providing a nebula or aerosol to a patient. In one aspect, a nebulizer is pressure sensitive so that nebulization is coordinated with a breathing cycle of the patient. The nebulizer includes a movable gas diverter that diverts pressurized gas across a liquid outlet. The diverter is moved in response to the patient's breathing cycle. In one aspect, a biasing member moves the diverter. According to another aspect of the nebulizer, an annular liquid orifice disperses an aerosol in a radial direction in response to a pressurized gas flow from an orifice located concentrically thereto. Multiple liquid orifices may be provided. In a further aspect of the nebulizer, a reservoir includes an upper, wide portion and a lower narrow portion to apply relatively uniform pressure at a liquid orifice.
Patent CA-2460700-A1 (CA)
Title: Hydroxylation de l'asparagine du domaine cad d'une proteine hif
Inventor: LANDO DAVID
IPC: C07K14/47
Filed: 2002-09-18
Abstract: Selon l'invention, un résidu d'une asparagine cible de HIF 1 alpha et 2 alpha est hydroxylée à une tension en oxygène élevée afin que HIF devienne un facteur de transcription faible. L'invention décrit un motif de fixation et un motif d'hydroxylation de l'hydroxylase d'une asparagine. Un procédé de criblage d'agonistes et d'antagonistes de l'hydroxylase d'une asparagine est aussi décrit. Ce procédé consiste à mélanger des peptides ou des protéines comprenant le motif d'hydroxylation et/ou de fixation avec l'hydroxylase asparagine et un agoniste ou antagoniste candidat. L'extension de l'inhibition et l'amélioration de la fixation, et le niveau d'hydroxylation ou la transactivation de l'asparagine peuvent être mesurés en fonction de la nature de la protéine ou du peptide. L'invention concerne en outre, des protéines modifiées résistant à l'hydroxylation, ainsi que les acides nucléiques codant ces protéines.
Patent CA-2462274-A1 (CA)
Inventor: CHEN YEN-LANE
IPC: C09K3/18
Filed: 2002-09-06
Abstract: An aqueous composition that includes silane including n-alkylalkoxysilane, condensates of n-alkylalkoxysilane or a combination thereof, and from about 0.01 % by weight to about 2 % by weight cationic quaternary surfactant. The composition optionally includes a siloxane selected from the group consistin g of methylhydrogen siloxane, methylhydrogen-methylalkyl siloxane copolymer, methylhydrogen-cyclosiloxane copolymer, methylhydrogen-methylalkyl cyclosiloxane copolymer and combinations thereof, and volatile carrier.</SDO AB>
Patent CA-2467568-A1 (CA)
Title: Appliance with integrated, vertically adjustable platform
Inventor: KHOSROPOUR MOSTAFA MICHAEL
IPC: A47B91/00
Filed: 2004-05-19
Abstract: An adjustable platform assembly for raising an appliance includes a platform with various spaced vertical leg members. Each of the leg members has a first mounting aperture for fixing an appliance to the platform, and a second mounting aperture for fixing an adjustable caster to the leg member. A consumer can adjust the platform assembly to a desired height by altering the height of the caster members. A decorative faceplate is provided which removably attaches to the front of the platform assembly to give the appliance a built-in look.
Patent CA-2471318-A1 (CA)
Inventor: EICHHORN ROLAND
IPC: B66B15/04
Filed: 2004-06-17
Abstract: The device for transporting a load comprises a movable traction means (50) connected with the load. A section of the traction means (50) is brought into contact with at least one roller (40) in order to guide the traction means. The roller comprises a coating (42) and a carrier (41) of the coating, wherein the traction means (50) can be brought into contact with the coating (42). A coefficient of friction for contact between the traction means (50) and the coating (42) is less than the corresponding coefficient of friction for contact between the traction means (50) and the carrier (41). The coating (42) reduces or avoids, on movement of the traction means (50) relative to the roller (40), torsion of the traction means (50) about the longitudinal direction thereof and/or deformation of the traction means (50) transversely to the direction of movement, particularly in the case of movement of the traction means (50) obliquely with respect to the longitudinal direction thereof, and reduces the sensitivity of the traction means (50) relative to wear, particularly for the case that the traction means (50) is under a diagonal tension.
Patent CA-2473023-A1 (CA)
Title: Surgical system and method of converting a clamp into an electrophysiology device
Inventor: SWANSON DAVID K
IPC: A61B18/12
Filed: 2002-11-25
Abstract: A surgical system including a clamp with first and second clamp members and a device that removably mounts at least one electrode on at least one of the first and second clamp members.
Patent CA-2473896-A1 (CA)
Inventor: COOTE STEVEN JOHN
IPC: C07J75/00
Filed: 2003-02-03
Abstract: A process for preparing fluticasone propionate as crystalline polymorphic Fo rm 1 which comprises reacting a compound of formula (II)or a salt thereof with a compound of formula LCH2F wherein L represents leaving group optionally in t he presence of a phase transfer catalyst, a water-immiscible non-solvating organic liquid solvent and water is described.
Patent CA-2474919-A1 (CA)
Inventor: SOFIA SUSAN J
IPC: A61P19/00
Filed: 2003-02-10
Abstract: Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.
Patent CA-2475036-A1 (CA)
Inventor: PATEL DINESH V
IPC: A61P31/04
Filed: 2003-02-04
Abstract: L'invention porte sur certains dérivés thiadiazinone d'oxazolidinones, agents antibactériens, de formule (I), et leurs sels pharmacocompatibles, ainsi que sur des préparations pharmaceutiques contenant lesdites thiadiazinones, sur leurs méthodes d'utilisation, et sur leurs procédés de préparation.
Patent CA-2476604-A1 (CA)
Title: Method of weed control
Inventor: SEKUTOWSKI DENNIS W
IPC: A01M29/00
Filed: 2003-02-10
Abstract: In one embodiment, the present invention relates to methods of reducing weed growth or reducing pests involving applying to plant producing media particulate materials to a depth of at least about 1 cm, wherein the plant producing media to the depth comprises about 1% by weight or more and about 25% by weight or less of particulate materials. In another embodiment, the present invention relates to methods of reducing weed growth involving applying to plant producing media or unwanted vegetation a film of particula te materials, wherein the film has a thickness of about 1 .mu.m or more and abo ut 5 mm or less.
Patent CA-2478646-A1 (CA)
Title: Equipment security device
Inventor: GALANT STEVE N
IPC: E05B73/00
Filed: 2003-03-04
Abstract: A security device for securing an equipment component such as a laptop computer, the security device including a first securing member including a first restraining member for engaging a first portion of the component, and an elongate arm extending from the first restraining member; and a second securing member including a second restraining member opposing the first restraining member for engaging a portion of the component that is spaced apart from the first portion, and a releasable locking device for engaging the arm to prevent movement of the first and second restraining members away from each other when in an engagement position; the first and second restraining members each including a first pair of spaced apart opposed engagement members for restraining movement of the component in a first plane, and a second pair of spaced apart opposed engagement members for restraining movement of the component in a second plane.
Patent CA-2483327-A1 (CA)
Inventor: KIM FELIX JINHYUN
IPC: A61K38/00
Filed: 2003-04-22
Abstract: The invention relates to the use of oligonucleotides from the nucleotide sequences coding for the amino-terminal region of the surface component (SU) of envelope proteins of PTLV viruses in order to perform methods of detecting every PTLV strain or PTLV-related viruses, e.g. for the detection of novel PTLV variants or viruses comprising sequences related to PTLV SUs. The invention also relates to primer pairs which are used to perform said detection methods and the novel PTLV variants thus detected.
Patent CA-2484537-A1 (CA)
Title: Telemetry downhole system and method
Inventor: BOYLE BRUCE W
IPC: E21B47/12
Filed: 2004-10-12
Abstract: A cabled communication link for a drill string includes spaced apart adapter subs within the drill string and a cable connecting the adapter subs for communication o f a signal therebetween. The cabled communication link may be drill pipe joints are interconnected within the drill string between adapter subs to form a piped communication link, whereby the cabled communication link establishes a pathway to the piped communication link for transmitting a signal through the drill string. The cabled communication link may also be i n a non-wired section of the drill string is disposed between adapter subs, whereby the cabled communication link establishes a pathway for transmitting a signal through the non-wired section of the drill string. Inductive couplings are preferably used for communication across the adapter subs and wired drill pipe joints. Another aspect of the cabled communication employs wireless transceivers at or near the surface of the wellbore.
Patent CA-2488010-A1 (CA)
Title: Electrically conductive/insulative over-shoe for tissue fusion
Inventor: MEAGHER EDWARD C
IPC: A61B18/14
Filed: 2004-11-19
Abstract: An over shoe for use with electrosurgical instruments having a pair of juxtaposed jaw members pivotably associated with one another, at least one of which includes an electrically conductive surface disposed thereon which is in electrical engagement with an electrosurgical energy source. According to one aspect of the present disclosure, the over shoe includes a tissue contacting wall configured and dimensioned to selectively and substantially overlie the electrically conductive surface of the electrosurgical instrument. The tissue contacting wall is fabricated from a non-conductive material and includes a plurality of apertures formed therethrough. In another embodiment, the tissue contacting wall is electrically conductive and is configured for selective engagement atop on of the jaw members.
Patent CA-2488478-A1 (CA)
Title: Vehicle stopping method and apparatus
Inventor: BOLL WILLIAM ROBERT
IPC: B60R25/09
Filed: 2004-11-25
Abstract: A vehicle stopping apparatus for stopping a target vehicle has a capture loop large enough to loop over a vehicle tire, attachment means provided over a portion of the capture loop to attach the portion of the capture loop to the vehicle tire, and a tether coupled to the capture loop. The vehicle stopping apparatus may have an anchoring device coupled to the tether, the anchoring device adapted to apply a resistive force on the tether.   Furthermore, the vehicle stopping apparatus may have a deployment mechanism adapted to transfer the capture loop from a set position wherein said capture loop is folded in a bundle, to a deployed position wherein said capture loop is extended across the path of said vehicle tire.
Patent CA-2491257-A1 (CA)
Inventor: CITERNESI UGO RAFFAELLO
IPC: A61K31/167
Filed: 2003-06-26
Abstract: Pharmaceutical formulations constituted by a lexitropsin phospholipidic complex in the form of liposomes, micelles or nanoparticles exhibit optimal pharmacological properties in respect to other formulations containing active principles belonging to the same chemical class in both the topical or parenteral treatment of infectious and/or tumour diseases.
Patent CA-2491989-A1 (CA)
Title: Compounds with antiparasitic activity and medicines containing same
Inventor: ESCALE ROGER
IPC: A61P33/00
Filed: 2003-07-18
Abstract: The invention concerns compounds with antiparasitic, in particular antimalarial, activity, characterized in that they are of general formula (I). The invention is in particular useful as compounds with anti-parasitic activity.
Patent CA-2492059-A1 (CA)
Title: Combinations of drugs for the treatment of neoplasms
Inventor: NICHOLS M JAMES
IPC: A61K31/496
Filed: 2003-07-11
Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
Patent CA-2492103-A1 (CA)
Title: Flavin n-oxides: new anti-cancer agents and pathogen eradication agents
Inventor: PLATZ MATTHEW S
IPC: A61K31/525
Filed: 2003-05-12
Abstract: Compounds comprising flavin N-oxides for treatments of solid tumors, non-sol id tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid ty pe cancers comprising administering a therapeutically effective amount of flavi n N-oxide to a subject in need of treatment and exposing the flavin n-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. methods of reducing pathogenic bacterial or rival contamination in a composition comprising a) mixing the composition with an efficacious amount of flavin N-oxide and b) exposing the mixture of the composition and the flavin N- oxide to an activator for a period of time sufficient to activate the flavin N- oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood produc t selected from plasma, platelets, and red blood cells, and the activator is a n enzyme.
Patent CA-2492153-A1 (CA)
Inventor: MOSS STEVEN
IPC: C07K14/36
Filed: 2003-07-16
Abstract: la pr~sente invention concerne la production de polyk~tides et autres produits naturels ainsi que des banques de compos~s et des compos~s individuels nouveaux. Un aspect important concerne l'isolement et l'utilisation potentielle de nouveaux analogues de ligand FKBP et des cellules hÙtes qui produisent ces compos~s. L'invention concerne en particulier des m~thodes de transformation efficace de souches produisant des analogues de FKBP et des cellules de recombinaison dans lesquelles des g­nes clon~s ou des cassettes de g­nes sont exprim~s et produisent des nouveaux compos~s tels que des analogues de ligand polyketidiques (en particulier la rapamycine) et leurs m~thodes de pr~paration et moyens utilis~s (tels qu'acides nucl~iques, vecteurs, cassettes de g­nes et souches g~n~tiquement modifi~es).