Patent SG-11202000321P-A (SG)
Title: Cd38 modulating antibody
Inventor: GOUBIER ANNE
IPC: A61K39/395
Filed: 2018-08-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo Hu vimIE (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/034752 Al (43) International Publication Date 21 February 2019 (21.02.2019) WIP0 I PCT ited, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage Hertfordshire SG1 2FX (GB). MOULDER, Kevin; c/o Tusk Therapeutics Limited, Stevenage Bio- science Catalyst, Gunnels Wood Road, Stevenage Hertford- shire SG1 2FX (GB). EISSLER, Nina; c/o Tusk Therapeu- tics Limited, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage Hertfordshire SG1 2FX (GB). FILOSTO, Simone; c/o Tusk Therapeutics Limited, Stevenage Bio- science Catalyst, Gunnels Wood Road, Stevenage Hertford- shire SG1 2FX (GB). BARUAH, Hemanta; c/o Adimab, LLC, 7 Lucent Drive, Lebanon, New Hampshire 03766 (US). PRINZ, Bianka; c/o Adimab, LLC, 7 Lucent Drive, Lebanon, New Hampshire 03766 (US). (74) Agent: LEONARD, Thomas Charles; Kilburn & Strode LLP, Lacon London, 84 Theobalds Road, London London WC1X 8NL (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (51) International Patent Classification: CO7K 16/28 (2006.01) A61P 35/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/EP2018/072271 (22) International Filing Date: 16 August 2018 (16.08.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/546,322 16 August 2017 (16.08.2017) US 62/582,653 07 November 2017 (07.11.2017) US 62/582,666 07 November 2017 (07.11.2017) US PCT/EP2018/065237 08 June 2018 (08.06.2018) EP (71) Applicant: TUSK THERAPEUTICS LTD [GB/GB]; Stevenage Bioscience Catalyst, Accelerator Building, Gun- nels Wood Road, Stevenage Hertfordshire SG1 2FX (GB). (72) Inventors: GOUBIER, Anne; c/o Tusk Therapeutics Limited, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage Hertfordshire SG1 2FX (GB). SALIMU, Josephine; c/o Tusk Therapeutics Limited, Stevenage Bio- science Catalyst, Gunnels Wood Road, Stevenage Hert- fordshire SG1 2FX (GB). GOYENECHEA, Beatriz; c/o Tusk Therapeutics Limited, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage Hertfordshire SG1 2FX (GB). MERCHIERS, Pascal; c/o Tusk Therapeutics Lim- (54) Title: CD38 MODULATING ANTIBODY 2000- -• Vehicle DARA aCD38-a-323 0 ; 1500- E e e N .N 1 1000- co L a E H 500- 1-1 It) N O C\ O 1-1 C•1 O 0 14 17 21 24 28 31 days after tumour inoculation (57) : The present disclosure provides antibody sequences found in antibodies that bind to human CD38. In particular, the present disclosure provides sequences of anti-human CD38 antibodies. Antibodies and antigen-binding portions thereof including such sequences present features compatible with pharmaceutical manufacturing and development can be provided as fully human antibodies (e.g., fully human monoclonal antibodies or antigen-binding fragments) that can be useful for medical methods and compositions, in particular for treating cancer. [Continued on next page] WO 2019/034752 Al 11111111111111111110101011111011111111111111111111111111011111111111111111111111111111111 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))