Patent SG-11201806692S-A (SG)
Title: Improved treatment of implants with phosphonic acid compounds
Inventor: BUCHINI SABRINA
IPC: A61L31/16
Filed: 2017-02-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 August 2017 (17.08.2017) WIPO I PCT (10) International Publication Number WO 2017/137623 Al 1111111111111101110111111111110101111101110111011111111111110111011111111111110111111 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (51) International Patent Classification: A61L 27/04 (2006.01) A61L 31/08 (2006.01) A61L 27/28 (2006.01) A61L 31/14 (2006.01) A61L 27/50 (2006.01) A61L 31/16 (2006.01) A61L 27/54 (2006.01) A61L 27/10 (2006.01) A61L 31/02 (2006.01) (21) International Application Number: PCT/EP2017/053139 (22) International Filing Date: 13 February 2017 (13.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16155497.7 12 February 2016 (12.02.2016) EP (71) Applicant: NANO BRIDGING MOLECULES SA [CH/CH]; Route de Cite Ouest 2, 1196 Gland (CH). (72) Inventors: BUCHINI, Sabrina; Chemin de la Raicettaz 5, 1188 St-George (CH). CURNO, Richard; Chemin de la Cote Viri 5, 1188 St-George (CH). ARONSSON, Bjorn- Owe; Chemin de la Dullive 8c, 1196 Gland (CH). PECHY, Peter; Avenue de Chailly 63, 1012 Lausanne (CH). = (74) Agent: VOSSIUS & PARTNER (NO 31); SiebertstraBe 3, 81675 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, W O 20 17 / 137 6 23 Al (54) Title: IMPROVED TREATMENT OF IMPLANTS WITH PHOSPHONIC ACID COMPOUNDS (57) : The present invention relates to a process of treating an implant, comprising a step of treating the surface of the im- plant with at least one phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof under sonication at a temperature of about 50°C to about 90°C. This process is highly advantageous in that it allows the formation of a monolayer of the phosphonic acid compound on the implant surface, having a particularly dense surface coverage which, in turn, results in an im- proved implant biocompatibility and improved osseointegration. The invention further relates to a surface-treated implant obtainable by this process and, in particular, it provides an implant having a surface made of a metal, a metal alloy or a ceramic, wherein a phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof is bound to the surface of the implant and forms a monolayer having an implant surface coverage, in terms of the ratio of the phosphorus content to the metal content as de - termined by X-ray photoelectron spectroscopy (XPS), of at least 70% of a reference maximum surface coverage.