Patent EA-000892-B1 (EA)
Title: Metered dose inhaler for salmeterol
Inventor: BRITTO IGNATIUS LOY
IPC: B65D83/14
Filed: 1996-04-10
Abstract: 1. A metered dose Inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients. 2. An inhaler according to claim 1 containing said drug formulation. 3. An inhaler according to claim 2, wherein said drug formulation further comprises a surfactant. 4. An inhaler according to claim 2 or 3, wherein said drug formulation further comprises a polar cosolvent. 5. An inhaler according to claim 2 wherein said drug formulation comprises 0.01 to 5% w/w based upon propellant of a polar cosolvent, which formulation is substantially free of surfactant. 6. An inhaler according to any one of claims 2 to 5, wherein said drug formulation comprises salmeterol or a physiologically acceptable salt thereof in combination with an antiinflammatory steroid or an antiallergic. 7. An inhaler according to claim 6, wherein said drug formulation comprises salmeterol xinafoate in combination with fluticasone propionate. 8. An inhaler according to claim 2, wherein said drug formulation consists essentially of salmeterol or a physiologically acceptable salt thereof, optionally in combination with one or more other pharmacologically active agents, and a fluorocarbon propellant. 9. An inhaler according to claim 8, wherein said drug formulation consists essentially of salmeterol or a physiologically acceptable salt thereof in combination with an antiinflammatory steroid or an antiallergic. 10. An inhaler according to claim 9, wherein said drug formulation consists essentially of salmeterol or a physiologically acceptable solvate thereof in combination with fluticasone propionate or a physiologically acceptable solvate thereof. 11. An inhaler according to claim 2, wherein said drug formulation consists of salmeterol or a physiologically acceptable salt thereof and a fluorocarbon propellant. 12. An inhaler according to any one of claims 2 to 11 wherein the salmeterol is in the form of the xinafoate salt. 13. An inhaler according to any one of claims 2 to 12, wherein the fluorocarbon propellant is 1,1,1,2 tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof. 14. An inhaler according to claim 13, wherein the fluorocarbon propellant is 1,1,1,2- tetrafluoroethane. 15. An inhaler according to any of claims 1 to 14 comprising a can made of metal wherein part or all of the internal metallic surfaces are coated. 16. An inhaler according to claim 15 wherein the metal is aluminium or an alloy thereof. 17. An inhaler according to any one of claims 1 to 16 wherein said fluorocarbon polymer is a perfluorocarbon polymer. 18. An inhaler according to claim 17 wherein said fluorocarbon polymer is selected from PTFE, PFA, FEP and mixtures thereof. 19. An inhaler according to any one of claims 1 to 18, wherein said fluorocarbon polymer is in combination with a non-fluorocarbon polymer selected from polyamide, polyimide, polyamideimide, polyethersulphone, polyphenylenesulphide and aminoformaldehyde thermoreactive resins. 20. An inhaler according to claim 19, wherein said fluorocarbon polymer is in combination with a non-fluorocarbon polymer selected from polyamideimide and polyethersulphone. 21 An inhaler according to any one of claims 1 to 20, wherein said polymer mixture comprises PTFE and polyethersulphone. 22. An inhaler according to any one of claims 1-21 comprising a substantially ellipsoidal base. 23. A metered dose inhaler system comprising a metered dose inhaler according to any one of claim 1 to 22 fitted into suitable channelling device for oral or nasal inhalation of the drug formulation. 24. Use of a metered dose inhaler system according to claim 21 for the treatment of respiratory disorders.