baber/WOPTO huggingface dataset:
Patent SG-11201908971R-A (SG)
Title: Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
Inventor: THROSBY MARK
IPC: C07K16/30
Filed: 2018-04-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT o °nolo ono! oni omoilimio oimIE (10) International Publication Number WO 2018/182422 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/30 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) (21) International Application Number: PCT/NL2018/050206 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17164292.9 31 March 2017 (31.03.2017) EP (71) Applicant: MERUS N.V. [NL/NL]; Yalelaan 62, 3584 CM Utrecht (NL). (72) Inventors: THROSEY, Mark; c/o Yalelaan 62, 3584 CM Utrecht (NL). GEUIJEN, Cecilia Ana Wilhelmina; c/o Yalelaan 62, 3584 CM Utrecht (NL). MAUSSANG-DE- TAILLE, David Andre Baptiste; c/o Yalelaan 62, 3584 CM Utrecht (NL). LOGTENBERG, Ton; c/o Yalelaan 62, 3584 CM Utrecht (NL). (74) Agent: JANSEN, C.M.; V.O., Carnegieplein 5, 2517 KJ Den Haag (NL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) 00 1-1 (54) Title: ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT F CELLS THAT HAVE 00 AN NRG1 FUSION GENE 0 (57) : The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies \" for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene 0 comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.
Patent IS-2363-B (IS)
Inventor: EGLI HERBERT
IPC: E21D9/10
Filed: 2005-04-11
Abstract: A method of reducing wear in a cutting head of a tunnel boring machine, by means of the addition at the cutting head of a foamed aqueous liquid composition, which comprises a foaming agent and a lubricant, the lubricant being selected from the group consisting of high molecular weight polyethylene oxides and bentonite. Preferred foaming agents are anionic and nonionic surfactants. Wear rates of cutting elements of TBMs boring in hard rock are considerably reduced. A wear-reducing foamable concentrate is also described.
Patent HU-202620-B (HU)
Title: Magnetic cylinder lock insert
Inventor: KASSZA TIBOR
IPC: E05B47/00
Filed: 1988-01-20
Abstract: The lock has a rotatable cylinder 2 having rotors 6, containing magnets 5 co-operable with key magnet, 12 - when the proper key 3 is placed into key channel 10 of cylinder 2 the dipole magnet fields a key magnet 12 affect the dipole magnet fields of rotor magnets 5 to turn the rotors 6 into an opening position where latch channels 11 on rotors 6 orientate and a latching element 8 moves into the latch channels to allow rotation of the lock cylinder. To eliminate wear and joining intermediate elements 8a in the form of steel balls/cylindrical rollers/needle rollers are arranged as shown between latching element 8 and lock body 1 and details are given. In Figures 8-18, six magnets are built into key 3 in twos but in Figures 19-20 three magnets magnetized in their full thickness are provided. The specification discloses details of the angular pitch of the magnets 12 - a pitch of at most 20 DEG  (preferably 11 DEG ) is envisaged (see Figures 6, 16, 17). <IMAGE>
Patent HU-195992-B (HU)
Inventor: DREXLER TIBOR
IPC: F41B7/08
Filed: 1984-02-10
Abstract: A találmány tárgya ügyességi játék céllövés gyakorlásához, amely játék lőfegyverekhez hasonló alakú testének markolata és/vagy puskatusa, elsütő billentyűje, elsütő rugója, felhúzó karja, kakasa és irányzó szervei vannak. Jellegzetessége, hogy a fegyver alakú testnek (1) az elsütő billentyűvel (10) működtetett, a célzás pontosságát regisztráló együttese, cserélhető célja, pl. lőlapja (5), az irányzó vonalra merőleges síkban a fegyver alakú testhez (1) viszonyítva elmozdulni képes, a cserélhető célt, pl. lólapot (5) befogadó céltartója (4), célzó támasza (7), a céltartót (4) mozgató rúdja (3) valamint a mozgató elemek szerepét betöltő célzó támasznak (7) és mozgató rúdnak (3) a fegyver alakú testhez (1) viszonyított elmozdulását megengedő csukló elemei (2, 6) vannak. (1. ábra)  195992 -1-
Patent HU-189127-B (HU)
Inventor: MANNING MAURICE
IPC: C07K7/16
Filed: 1982-03-23
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung neuer Peptide, die antivasopressorische Aktivitaet gegen Arginin-Vasopressin besitzen. Die durch das erfindungsgemaesse Verfahren hergestellten Verbindungen sind durch die allgemeine Formel gekennzeichnet, in welcher X gleich H, Methyl oder Ethyl sein kann, sowie Z D- oder L-Arg darstellt. Durch das erfindungsgemaesse Verfahren werden pharmakologisch und klinisch wirksame Antagonisten der antidiuretischen Wirkung von Arginin-Vasopressin zur Verfuegung gestellt.
Patent HU-200285-B (HU)
Title: Cross-flow liquid filter operating under pressure
Inventor: BORNEMISZA ENDRE
IPC: B01D35/22
Filed: 1987-03-04
Abstract: A filter for liquids, having a porous filter insert 4, which is arranged in a housing 3 and is designed as a hollow rotary body, wherein a flow passage 5, which helically surrounds the filter insert and is in communication with an inlet opening 1 at one end of the housing and an outlet opening 2 at the other end of the housing, is provided for the prefilt feed between the inner wall of the housing 3 and the outer wall of the filter insert 4, and the interior of the filter insert 4, at one end, is in communication with an outlet opening 6 for the cleaning liquid. The cross section of the flow passage 5 decreases continuously from the inlet opening 1 to the outlet opening 2. <IMAGE>
Patent LT-4350-B (LT)
Title: Oral 2-methyl-thieno-benzodiazepine formulation
Inventor: COCHRAN GEORGE RANDALL
IPC: A61K9/36
Filed: 1997-09-16
Abstract: The invention provides a pharmaceutically elegant solid oral formulation of olanzapine and a process for making such formulation.
Patent LT-3681-B (LT)
Title: N-acyl-alpha-amino acid derivatives, method for producting thereof,pharmaceutical compositions and preparing them
Inventor: ALIG LEO
IPC: C07D401/12
Filed: 1993-08-16
Abstract: N-Aroyl-α- amino carbonic acid formula of which is<IMAGE>where α, R'-R''' and Q meanings are indicated in description, derivatives may be used for treatment and prevention of diseases, caused by connection of adhesive proteins with thrombocyte as well as aggregation of thrombocytes and connection of cell-cells. These derivatives are obtained by splitting protective groups of certain compounds or changing a corresponding group of nitrile cyan by an amide group.
Patent RS-49507-B (RS)
Title: Process for the preparation, preferably from waste materials, of silicate foam with closed pores and the product produced by that process
Inventor: HOFFMANN LASZLO
IPC: B09B3/00
Filed: 1999-03-05
Abstract: The process of the invention characterized in that to 100 parts by weight of a silicate powder having 2000-8000 m2/g specific surface, 1-10 parts by weight of gas-forming material with particle size of 10-100 mum and 0.5-15 parts by weight of montmorillonite, 0.5-2 parts by weight of alkali hydrogen phosphate or alkali dihydrogen phosphate or a mixture of alkali metal phosphate and sodium silicate in form of aqueous solution, 0.01-5 parts by weight of rare earth metal oxide or a mixture of such oxides were added, then the mixture obtained is homogenized, pre-dried, coated with 1-5 parts by weight of titanium oxide and/or titanium oxide hydroxide and/or aluminum oxide hydroxide, then subjected to heat treatment at 720-1000° C., and the mixture obtained is molded. The subject of the invention: also the product of the above process.
Patent RS-49566-B (RS)
Inventor: NERURKAR MANEESH J
IPC: C07K7/56
Filed: 1998-10-15
Abstract: Farmaceutska kompozicija za intravenoznu primenu na pacijenta, naznačena time, da sadrži: a) farmaceutski efikasnu količinu jedinjenja koje ima formulu i njegovih farmaceutski prihvatljivih soli, b) farmaceutski prihvatljivu količinu inertnog punioca kao što je sredstvo za punjenje koje je efikasno u formiranju liofilizovanog kolača; i c) farmaceutski prihvatljivu količinu acetatnog pufera koji je efikasan u obezbeđivanju farmaceutski prihvatljive pH vrednosti. Prijava sadrži još 3 nezavisna i 9 zavisnih patentnih zahteva. <patent>
Patent YU-43655-B (YU)
Title: Improvement in the process of obtaining melamine
Inventor: HARDEVELD R VAN
IPC: C07D251/10
Filed: 1983-03-28
Abstract: An improved process for the preparation of melamine from urea or thermal decomposition products thereof. A melamine containing reaction mixture is cooled with an aqueous medium to form an aqueous product stream containing melamine and reaction by-products. Product melamine is separated from the aqueous product stream leaving a residual aqueous stream which is recycled into the process. A portion of this residual aqueous stream still containing reaction by-product is treated to remove by-products therefrom prior to being recycled to the process.
Patent AT-393642-B (AT)
Inventor: KULMBURG ALFRED DR
IPC: C22C33/02
Filed: 1988-06-21
Granted: 1991-11-25
Abstract: Use of an iron-based alloy for the production of sintered parts of high corrosion resistance, high wear resistance, high toughness and high compressive strength, in particular for processing plastics, having a composition, in % by weight, chromium 16.0-29.0, molybdenum 0.4-2.5, tungsten 0.3-2.0, vanadium 3.0-10.0, titanium up to 5.0, aluminium up to 1.0, boron up to 0.05, nitrogen 0.01-0.18, niobium up to 5.0, iron and preparation-related impurities as the remainder, the value formed from (% of Cr - 13) + 4.4 x (% of V - 3) + 2 x (% of Nb) + 4.2 x (% of Ti) being greater than 8.8, and the minimum carbon content of the alloy corresponding to the correlation Cmin = 0.3 + [(% of Cr - 13) x 0.06] + [(2 x % of Mo + W) x 0.03] + (% of V x 0.24) + (% of Nb x 0.13) + (% of Ti x 0.25) and the maximum carbon content of the alloy corresponds to the correlation Cmax = 0.7 + [(% of Cr - 13) x 0.06] + [(2 x % of Mo + W) x 0.03] + (% of V x 0.24) + (% of Nb x 0.13) + (% of Ti x 0.25), with the proviso that the matrix has a chromium content of at least 13% after hardening and annealing, and the carbide content is at least 25% by volume, the carbide grain size being less than 14  mu m and at least 5 % by volume of the carbides being in the form of MC carbides.
Patent AT-394654-B (AT)
Title: Testphantom for continuously monitoring the image quality in X-ray diagnostics (radiodiagnosis)
Inventor: HOFMANN-PARISOT MARGARETE DR
IPC: A61B6/00
Filed: 1988-08-08
Granted: 1992-05-25
Abstract: The concrete testphantom to be patented is in the form of a staircase with steps of different radiographic density and is made from tissue-similar material. When used in X- ray diagnostics after appropriate calibration, it permits the immediate assessment of the X-ray image (radiogram, radiograph) produced on the patient. It is placed next to the body region to be investigated and represented simultaneously on the X-ray image. The image-determining parameters (density range (scale), optical densities (blackening) and density differences (contrast conditions)) can be detected in the X-ray image, in the appropriate section relevant to the diagnosis, by densitometry. However, by correlating contrast and the recognizability of detail, it is possible to make the assessment without additional measuring instruments and without any outlay on measurement, merely on the basis of a built-in contrast/detail test (as far as a specific region of cavities, holes to be detected) with the aid of a table or graphics. After appropriate calibration, the concrete invention can be used universally in human and veterinary medicine.
Patent AT-388006-B (AT)
Title: Safety guiding device for delimiting traffic areas, in particular roads and carriageways
IPC: E01F15/08
Filed: 1986-08-07
Granted: 1989-04-25
Abstract: The safety guiding device for delimiting traffic areas, in particular roads and carriageways, comprises elongated concrete parts 9 which are put together or can be put together with abutting longitudinal ends to form a bordering barrier and have a protective surface layer 5 made of plastic or synthetic-resin material, forming a lost formwork for the concrete parts. To increase durability and safety, the protective surface layer 5 is formed, at least on the visible sides of the concrete parts directed towards the traffic area, as a surface reinforcement for the concrete core 9, which adheres to the concrete core, forms a composite body with the latter and a concrete reinforcement 7, 8 and preferably itself contains a fibre reinforcement. The concrete parts are braced with one another by means of longitudinal tendons to form a continuous barrier. <IMAGE>
Patent AT-386483-B (AT)
Title: Method of determining the wear of hydraulic pumps and apparatus for implementing this method
Inventor: SCHELLENBERG EDUARD DIPL ING
IPC: G01F25/00
Filed: 1986-09-09
Granted: 1988-08-25
Abstract: In a method of determining the wear of hydraulic pumps 2 or hydraulic motors, in particular of pumps with an adjustable suction capacity, in which the pressure in the hydraulic-medium feed line and discharge line 3 and the flow of the hydraulic medium are measured and evaluated, the procedure is such that, on the basis of the measured pressure values, flow values corresponding to an idling pressure and flow values corresponding to a full-load pressure are averaged separately, and the averaged full- load flow is divided by the averaged idling flow. In an apparatus for implementing this method, having at least one pressure sensor 5, 6 connected into a hydraulic line 3 and at least one flow sensor 4, the signals from the pressure sensor or the pressure sensors 5, 6 are fed to a switch 8, which switches the signals from the flow sensor 4 to at least one memory 11 for idling flow measured values and at least one memory 12 for full-load flow measured values on the basis of the measured pressure value, and there is connected to the memories 11, 12 a divider circuit 15 for flow measured values stored in various memories. <IMAGE>
Patent CH-623190-B (CH)
Inventor: FUJITA MASANORI
IPC: G04G9/12
Filed: 1977-02-25
Abstract: With the purpose of reducing the number of connections necessary for a liquid-crystal display, the method consists in subdividing the display device into subdivisions each comprising a control electrode and in grouping together into a common connection several selection electrodes, each of which faces a different control electrode. Applied to the control electrodes are pulse trains (y0, x1-x3) constituting, for each control electrode, a different combination of binary signals, with the same total mark-space (pulse) ratio, and applied, at each common connection of the selection electrode, another pulse train corresponding to one of a plurality of binary combinations of logic levels (Y1-Y8). The choice between these combinations of pulse trains applied to the selection connections makes it possible to excite the corresponding element, as desired, in none, in any one, in any two, ... in any (n-1) and in the n subdivisions of the display device. Such a method for the multiplexed control of a display device is very economic, requires only a minimum of connections and provides a high (distinct) and uniform contrast for the display. <IMAGE>
Patent CH-644239-B (CH)
Inventor: WILLY CLEUSIX
IPC: G04B29/02
Filed: 1981-04-16
Abstract: The various pivoting members-setting-lever (3), rocker lever (14) and correction lever (16)-of a setting mechanism having a setting stem (2) are held in place and pivoted by means of a metal bridge (90) an arm (9) of which forms the setting-lever spring. The setting-lever, the rocker lever and the correction lever are interposed between the plate (1, 10, 11) of the movement and the bridge which not only provides for holding them in position but also provides for pivoting thereof. For that purpose, these three pivoting members each carry an arbor (4, 15, 17), which is fitted thereto and which has two end sections (4a, 15a, 17a; 21) projecting outside of said pivoting member. One of these end sections (21) engages without appreciable clearance into a corresponding hole (101) in the bridge and the other end (4a, 15a, 17a) is located with substantial clearance in a corresponding hole (20) in the plate and serves for the prepositioning of said pivoting element on said plate.
Patent DK-163649-B (DK)
Inventor: LAGNIER ALAIN
IPC: B60C11/12
Filed: 1988-03-09
Abstract: In order to improve the wear life of a tread having elements in relief which are provided with numerous incisions, each element in relief which is defined by circumferential grooves and transverse grooves comprises an even number of incisions which have rectilinear traces on the surface of the tread and, in cross-section, broken line or undulated line traces, the mean axes of which are perpendicular to the surface of the tread, and in such manner that the trace of one incision is identical to the symmetrical trace, with respect to its mean axis, of the trace of a circumferentially adjacent incision.
Patent DK-164988-B (DK)
Inventor: KRAMANN BERNHARD
IPC: A61M25/00
Filed: 1983-08-16
Abstract: PCT No. PCT/EP82/00270 Sec. 371 Date Aug. 16, 1983 Sec. 102(e) Date Aug. 16, 1983 PCT Filed Dec. 17, 1982 PCT Pub. No. WO83/02064 PCT Pub. Date Jun. 23, 1983.A novel catheter with a guide wire, the tip of which is bent in the manner of a walking stick, enables central veins to be rapidly and safely catheterized via a peripheral approach.
Patent FI-76869-B (FI)
Inventor: OLSSON ROLF
IPC: F16B39/10
Filed: 1982-12-08
Granted: 1988-08-31
Abstract: A locking device for fasteners such as hex nuts and bolt heads comprises plate-like body having an opening with centrally directed teeth which engage the nuts or heads when the device is pressed over them. A spring device or a bolted connector forces the locking device into a canted position in which it locks itself to the nut or head. By connecting pairs of such locking devices to each other, adjacent nuts or heads are prevented from rotating.
Patent FI-79400-B (FI)
Inventor: TAYLOR WILLIAM
IPC: F16D3/84
Filed: 1983-02-04
Granted: 1989-08-31
Abstract: A guard for a power transmission shaft such as a tractor pto shaft 18,20 comprises a flexible convoluted tubing 24 with end couplings 26 which together totally enclose the rotating parts. The tubing 24 can extend and retract axially to suit a variety of shaft lengths, and can flex transversely to accommodate turning of the tractor/implement combination. A tube 34 journalled on bearings 36, or equivalent bearing means, prevents damage to the tubing 24 by the shaft 18,20.
Patent FI-76578-B (FI)
Inventor: FABRE JEAN-LOUIS
IPC: C07D471/04
Filed: 1984-01-12
Granted: 1988-07-29
Abstract: Antithrombotics of the formula   <IMAGE>   in which A=S, SO or SO2, R3=H, alkyl or substituted or unsubstituted phenyl, X=O, S, NH or variously substituted nitrogen, p is 0 or 1 and y=H, NH2, or various substituted amines.
Patent FI-80403-B (FI)
Inventor: MEUZELAAR BOB
IPC: C25D5/08
Filed: 1985-05-06
Granted: 1990-02-28
Abstract: A metal screen material comprising a metal screen, preferably a cylindrical screen, obtained by electrolytic deposition of a metal upon a screen skeleton and said screen material having a fineness of 250 to 1000 mesh. The screen opening is preferably defined by curved walls extending from the lower side of the screen opening to the upper side of the screen opening, the upper side of the screen opening having an area being larger than the lower side of the screen opening. The screen material is advantageously obtained by electrolytic deposition of a metal from an electrolytic bath upon a screen skeleton, the bath solution passing, at least during part of the electrolytic depositing time, through the openings in the screen skeleton connected as the cathode either in one direction or in the other reverse direction.
Patent FI-83062-B (FI)
Inventor: PUPP HERWIG
IPC: B65D5/46
Filed: 1985-08-29
Granted: 1991-02-15
Abstract: A pack for containing materials which are capable of flow includes a tube formed by a longitudinal sealing seam, along with a bottom and a cover closing the tube ends. The cover is formed from thermoplastic material without a carrier material, is injected on the tube, and has a pouring spout. The tube comprises cardboard which is coated with thermoplastic material on one side. The bottom is quadrangular, formed from the folded-over tube of the pack of a fold-type closure. The cover and the cross-section of the pack, at least in the region of the cover, are round. To improve such a pack with a handle so that the final consumer enjoys improved handleability and transportability, the invention provides that a portion of the tube wall, which adjoins the periphery of the cover, is folded onto itself, forming a handle, and is joined to provide a double-wall surface portion in which a gripping opening is provided. The cover is extended over the upper edge of the double-wall surface portion with the gripping opening to provide a stiffening web.
Patent FI-89950-B (FI)
Inventor: WATANABE ATSUO
IPC: C23C4/02
Filed: 1986-04-29
Granted: 1993-08-31
Abstract: A paper machine press roll comprising, as integrally joined together, a metal core (2), a ground layer (4) comprising a metal material layer formed over the outer periphery of the core and having a smaller coefficient of expansion than the surface material of the core, and a ceramics layer (3) formed over the ground layer and having a porosity of 1 to 30%.
Patent FI-86058-B (FI)
Inventor: GOETTSCHE REIMER
IPC: A01N43/84
Filed: 1987-02-13
Granted: 1992-03-31
Abstract: 1. The salt of N-tridecyl-2,6-dimethylmorpholine with fluoboric acid.
Patent FI-85151-B (FI)
Inventor: ALA-HUIKKU SIRPA
IPC: C08F4/654
Filed: 1989-09-06
Granted: 1991-11-29
Abstract: The invention provides an olefin polymerization catalyst system of which the procatalyst comprises a solid carrier with a magnesium compound, an electron donor compound and monocyclopentadienyl titanium trichloride on its surface. A method for the preparation of such a procatalyst is also disclosed, comprising impregnating a solid carrier with a solution obtainable by dissolving a magnesium compound and monocyclopentadienyl titanium trichloride in a compound having electron donor properties. The use of the olefin polymerisation catalyst system in a process for polymerizing olefins is also disclosed.