baber/WOPTO huggingface dataset:
Patent CA-3045339-A1 (CA)
Inventor: PORTS MICHAEL
IPC: C07K16/28
Filed: 2017-12-01
Abstract: La présente invention concerne des méthodes, des compositions et des utilisations impliquant des immunothérapies et des inhibiteurs d'une protéine tyrosine kinase cible dans laquelle la kinase est autre qu'une kinase de lymphocyte T inductible par IL-2 (ITK) et/ou est choisie parmi la tyrosine kinase de Bruton (BTK), la protéine tyrosine kinase tec (TEC), la tyrosine kinase non réceptrice BMX (Etk), la tyrosine kinase TXK (TXK) et/ou la tyrosine kinase réceptrice ErbB4 (ErbB4). Les méthodes, compositions et utilisations de l'invention comprennent l'administration d'un ou de plusieurs de ces inhibiteurs avec un autre agent, tel qu'un agent immunothérapeutique ciblant des lymphocytes T et/ou des lymphocytes T génétiquement modifiés, tels que des lymphocytes T exprimant CAR. L'invention concerne également des procédés de production de cellules modifiées, des compositions, des méthodes d'administration, des acides nucléiques, des articles manufacturés et des kits. Selon certains aspects, les caractéristiques des méthodes et des cellules procurent une activité, une efficacité, une persistance, une expansion et/ou une prolifération améliorées des lymphocytes T pour une thérapie cellulaire adoptive ou des lymphocytes T endogènes recrutés par des agents immunothérapeutiques.
Patent CA-3049351-A1 (CA)
Inventor: KUIPERS JOHAN RITSER
IPC: A61B5/18
Filed: 2018-01-03
Abstract: The invention provides assessment system for assessing a performance of at least one autonomous actor in a dynamic environment, said assessment system comprising a computer program which, when operating on a data processing system: - retrieves input selected from digital information, sensor data and a combination thereof, for detecting and classifying said at least one autonomous actor that is present in said dynamic environment; - set up a virtual reality simulation of said dynamic environment, and synchronizing said virtual reality simulation with said dynamic environment; - evaluate behavior of said at least one autonomous actor in said dynamic environment, said evaluating comprising measuring, analyzing and classifying actions and reactions of said at least one autonomous actor in said synchronized virtual reality simulation while said autonomous actor performs at least one predefined procedures in said dynamic environment; - compares said behavior of said at least one autonomous actor with a curriculum, said curriculum comprising at least one documented procedure and at least one documented performance value of said at least one predefined procedure; - output a qualification for said performance.
Patent CA-3051948-A1 (CA)
Inventor: BRUCE DAVID
IPC: F02M31/10
Filed: 2019-08-14
Abstract: In some embodiments, a fuel temperature sensor is located proximate to a vehicle component that is expected to experience fuel gelling, such as near or within a fuel filter, in order to obtain temperature information that accurately reflects the likelihood of fuel gelling occurring within the component. The proximate fuel temperature sensor can provide more accurate temperature information for components such as fuel filters that are installed at the periphery of the vehicle, compared to other temperature sensors that measure oil temperatures or other temperatures of centrally located vehicle components.  In some embodiments, the vehicle is automatically started when the temperature indicated by the fuel temperature sensor falls below a startup temperature threshold value, and is automatically stopped after a predetermined time period or after the temperature reaches a shutdown temperature threshold value.
Patent CA-3054718-A1 (CA)
Title: C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency
Inventor: GALLAGHER CYNTHIA
IPC: A61P7/10
Filed: 2014-03-17
Abstract: Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficiency are disclosed.
Patent CA-3059145-A1 (CA)
Inventor: TRAUTMAN MARK A
IPC: H05B6/46
Filed: 2019-10-17
Abstract: A method of producing hydrocarbon resources from a subterranean formation may include heating the subterranean formation with at least one radio frequency (RF) antenna located in an upper well within the subterranean formation. The method may further include producing hydrocarbon resources from a lower well within the heated subterranean formation and vertically beneath the upper well to create a void within the subterranean formation, and injecting a solvent into the void within the heated subterranean formation from the lower well.
Patent CA-3059160-A1 (CA)
Title: Fraud prevention via beneficiary account validation
Inventor: YAMANE MARCUS
IPC: G06Q20/38
Filed: 2019-10-18
Abstract: Disclosed are methods, systems, and devices for preventing payments to unintended beneficiaries. A service provider system may receive, from a user device of a user, a payment request to transfer funds from a source account to an identified destination account. A  beneficiary system may be identified, and a validation request (e.g., an API  call) may be transmitted to the beneficiary system. The service provider system may receive from the beneficiary system a transmission indicating whether the destination account is associated with the recipient identified in the payment request. The user may be alerted if the account number for the destination account is not validated.
Patent CA-3059785-A1 (CA)
Inventor: THALLADI VENKAT R
IPC: A61K31/4545
Filed: 2018-04-30
Abstract: L'invention concerne des méthodes de traitement de maladies oculaires et de certaines maladies respiratoires à l'aide du composé 5-éthyl-2-fluoro~4-(3-(5-(1-méthylpipéridin-4-yl)-4,5,6,7- tétrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phénol ou un sel pharmaceutiquement acceptable de celui-ci.
Patent CA-3060567-A1 (CA)
Inventor: PANAMARATHUPALAYAM BALAKRISHNAN
IPC: C09K8/68
Filed: 2017-01-06
Abstract: A breaker fluid includes a base fluid; lactide; and a mixture of hydrolyzable esters of dicarboxylic acids. A method of breaking a filtercake in a wellbore includes circulating a breaker fluid into the wellbore, the breaker fluid including: a base fluid;  lactide; and a mixture of hydrolyzable esters of dicarboxylic acids.
Patent CA-3061799-A1 (CA)
Inventor: SHIBAYAMA TAKASHI
IPC: B22F9/08
Filed: 2019-11-15
Abstract: A metal powder production apparatus capable of easily preventing an oxide in a molten metal from entering a liquid nozzle is provided. The metal powder apparatus includes a first crucible heating and melting a melting material to generate molten metal, a first heating device heating and melting the metal in the first crucible, a stopper opening and closing a first opening provided on the bottom surface of the first crucible, an introduction pipe having one end connected to the first opening of the first crucible and leading a molten metal in the first crucible to the outside of the first crucible, a second crucible receiving the molten metal flowing out of the introduction pipe, a second heating device heating the second crucible, and a liquid nozzle provided on the bottom surface of the second crucible.
Patent CA-3065716-A1 (CA)
Title: Rotary latch device
Inventor: LIVINGSTON JIMMY
IPC: E21B33/03
Filed: 2019-12-20
Abstract: ABSTRACT [0055] A latching assembly to couple a first mandrel to a second mandrel is disclosed. The latching assembly includes a plurality of wedge members disposed circumferentially and a guide plate. Each wedge member may include a semi-annular wedge body, an upper engagement lip, a lower engagement lip, and a guide pin. The guide plate may include a plurality of guide slots to translate and rotate the plurality of wedge members via the respective guide pins. Because the plurality of wedge members can be translated and rotated to lock and release the first mandrel to and from the second mandrel, the latching assembly can simplify the connection and disconnection of a first mandrel with the second mandrel. CA 3065716 2019-12-20
Patent CA-3066453-A1 (CA)
Inventor: IGAWA TOMOYUKI
IPC: A61K39/395
Filed: 2008-09-26
Abstract: The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated from disulfide bonds in the hinge region, reduced heterogeneity originated from the H chain C terminus, and increased stability at high concentrations as well as in discovering novel constant region sequences having reduced Fc.gamma. receptor-binding, while minimizing the generation of novel T-cell epitope peptides. As a result, the present inventors successfully discovered antibody constant regions with improved physicochemical properties (stability and homogeneity), immunogenicity, safety, and pharmacokinetics.
Patent CA-3071565-A1 (CA)
Inventor: HARFMANN WATLER R
IPC: C08J9/12
Filed: 2018-10-29
Abstract: A method for producing low density polyester foam utilizing low I.V. polyester feedstock includes providing a low intrinsic viscosity raw material. The low intrinsic viscosity raw material includes between 25% to 100% of a post consumer polyester and has an intrinsic viscosity of less than 0.8 dl/g. The intrinsic viscosity of the low intrinsic viscosity raw material is increased via a de-condensation reaction configured to support foaming. The intrinsic viscosity of the low intrinsic viscosity raw material is increased to 1.1 dl/g or greater. A starting formulation is created including the low intrinsic viscosity raw material with the increased intrinsic viscosity. The starting formulation is foamed to create the polyester foam. Wherein, the polyester foam produced has a specific gravity of less than 0.65 g/cc.
Patent CA-3071944-A1 (CA)
Title: Systemes et procedes pour dispositifs de prehension par aspiration robotiques
Inventor: MCCOY JOHN C
IPC: B25J15/06
Filed: 2018-09-20
Abstract: Selon un mode de réalisation donné à titre d'exemple, un système robotique de tri sous vide comprend : un mécanisme de préhension par aspiration monté sur un robot de tri ; un système à vide accouplé au mécanisme de préhension par aspiration ; une logique et de l'électronique de commande de robot accouplées au robot de tri et au système à vide ; et un dispositif d'imagerie accouplé à la logique et à l'électronique de commande de robot. En réponse à un signal d'image provenant du dispositif d'imagerie, la logique et l'électronique de commande de robot délivrent en sortie des signaux de commande de robot pour commander le robot de tri, et délivrent en sortie un ou plusieurs signaux de commande d'écoulement d'air au système à vide pour exécuter une action de capture sur un objet cible à l'aide du dispositif de préhension par aspiration. Pendant l'action de capture, la logique et l'électronique de commande de robot délivrent en sortie des signaux de commande de telle sorte que le système à vide tire un vide au niveau de l'orifice de préhension du mécanisme de préhension par aspiration lorsque le mécanisme de préhension par aspiration est appliqué pour capturer et maintenir l'objet cible.
Patent CA-3072021-A1 (CA)
Inventor: MANABE AKIYOSHI
IPC: C25B9/23
Filed: 2017-09-07
Abstract: Provided is an electrolytic apparatus capable of pressurizing hydrogen gas produced by the electrolytic apparatus and removing impurities in the produced hydrogen gas . In the electrolytic apparatus, gas compression means 101 including an ejector 110, a storage tank 103 storing a circulation liquid, a circulation pipe 105 circulating a fluid mixture of hydrogen gas and the circulation liquid to the ejector, and a circulation pump 104 is provided in a discharge line 12 for hydrogen gas produced by electrolysis, a hydrogen gas discharge pipe 106 and a first valve V1 are provided in the storage tank 103, impurities in the hydrogen gas are transferred to the circulation liquid to remove the impurities from the hydrogen gas, and a pressure of the hydrogen gas stored in the storage tank 103 is raised by controlling a flow rate of the circulation liquid circulated from the storage tank 103 to the ejector 110 and opening and closing of the first valve V1 .
Patent CA-3072348-A1 (CA)
Title: Steelmaking and ironmaking scrap segregation and packaging system and method thereof
Inventor: MANASEK RICHARD
IPC: C21C5/52
Filed: 2018-08-22
Abstract: A method of charging a pre-packaged charge in a metallurgical or refining furnace includes providing a disposable metal container having at least one attachment member and forming a pre-packaged charge by loading scrap material into the metal container. The method also includes releasably coupling the at least one attachment member of the container to a lifting device, and then de-coupling the pre-packaged charge from the lifting device so that the combination of the scrap material and the disposable metal container are charged in the furnace.
Patent CA-3075032-A1 (CA)
Inventor: REED TARRIS A
IPC: H02P6/00
Filed: 2020-03-10
Abstract: A system and method for replacing a sixteen-pin ECM with a non-sixteen-pin, field adjustable ECM in an HVAC or other system, and adjusting the performance of the replacement motor at the point of installation. A converter module receives programming information from an existing control board via an existing sixteen-pin harness, and converts the information to six signals. The module includes potentiometers for tuning speed/torque for first and second settings, adjusting a horsepower output of the replacement ECM, and adjusting a ramp time to increase or decrease a rate at which the speed/torque changes. The module includes switches for selecting between clockwise and counterclockwise directions for the replacement ECM, selecting between PWM and non-PWM control, and selecting between torque and speed modes. A non-sixteen-pin motor controller receives the information from the converter module via a four-wire harness, translates the information, and outputs a control signal to the replacement ECM.
Patent CA-3078900-A1 (CA)
Title: Oral rifamycin sv compositions
Inventor: MORO LUIGI
IPC: A61K9/20
Filed: 2018-11-07
Abstract: Oral pharmaceutical compositions containing rifamycin SV, or a pharmaceutically salt thereof, characterized in that they are formulated in a higher strength (about 600 mg/tablet) and in such a manner to obtain a modified profile of the rifamycin SV, or a pharmaceutically acceptable salt thereof, in the proximal portion of the intestine, i.e. in the small intestine (duodenum, jejunum and ileum). In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of small intestine bacterial overgrowth (SIBO) and/or irritable bowel syndrome (IBS) and/or in the treatment of cholera. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of hepatic encephalopathy, hepatic cirrhosis, pouchitis and/or spontaneous bacterial perotinitis. In one embodiment, the disclosed oral pharmaceutical compositions are used in the prevention and/or treatment in a subject of non- alcoholic fatty liver disease, non-alcoholic fatty liver or non-alcoholic steatohepatitis.
Patent CA-3079490-A1 (CA)
Inventor: BEGIN JASON
IPC: E06B9/26
Filed: 2011-07-18
Abstract: An apparatus and method for cutting a packaged window covering are provided.  An engagement member, supported relative to a support surface, is movable between an extended position where it projects into engagement with the packaged window covering and a retracted position where it retracts therefrom. A clamp assembly is movable to press the packaged window covering against the support surface. The clamp assembly and packaged window covering are movable relative to the engagement member and the support surface and toward and away from cutting devices when the engagement member is in the retracted position. A controller controls movement of the clamp assembly to automatically position a first end of the packaged window covering relative to a first cutting device and a second end of the packaged window covering relative to a second cutting device.
Patent CA-3079849-A1 (CA)
Title: Systems and methods for delivering neuroregenerative therapy
Inventor: WILLAND MICHAEL PATRICK
IPC: A61N1/00
Filed: 2018-10-24
Abstract: Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.
Patent CA-3080842-A1 (CA)
Title: Compose macrocyclique servant d'inhibiteur de wee1 et ses applications
Inventor: QIAN WENYUAN
IPC: C07D471/04
Filed: 2018-10-31
Abstract: La présente invention concerne un composé macrocyclique servant d'inhibiteur de Wee1, et ses applications dans la préparation de médicaments pour le traitement de maladies liées au Wee1. La présente invention concerne, en particulier, un composé représenté par la formule (II), un isomère de celui-ci, et un sel pharmaceutiquement acceptable de celui-ci.
Patent CA-3081505-A1 (CA)
Title: Optimizing electromagnetic telemetry transmissions
Inventor: LIU JILI
IPC: H04W4/38
Filed: 2014-08-28
Abstract: An electromagnetic telemetry system adjusts telemetry parameters which may include carrier frequency, signal amplitude and!or data encoding protocol to achieve reliable data transmission and to conserve power. In some embodiments, sweep signals transmit a range of carrier frequencies and the parameters arc determined in part by analyzing the received sweep signals. In some embodiments, different parameters are selected automatically based on a mode of drilling.
Patent CA-3085272-A1 (CA)
Title: Antisense compositions and methods of making and using same
Inventor: BARONI SERGIO
IPC: A61K9/00
Filed: 2009-11-13
Abstract: The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations can be used to treat Crohn's disease, ulcerative colitis and chronic inflammatory bowel disease.
Patent CA-3088331-A1 (CA)
Inventor: HANCOCK CHRISTOPHER PAUL
IPC: A61N1/32
Filed: 2019-03-08
Abstract: La présente invention concerne un générateur électrochirurgical capable de fournir de l'énergie dans une forme d'onde qui provoque une électroporation dans un tissu biologique. Le générateur électrochirurgical peut comprendre une unité d'alimentation de forme d'onde d'électroporation qui est intégrée avec des moyens pour générer des signaux électromagnétiques de micro-ondes et des signaux électromagnétiques de radiofréquence pour un traitement. Le générateur électrochirurgical peut être configuré pour délivrer différents types d'énergie le long d'un câble d'alimentation commun. L'unité d'alimentation en forme d'onde d'électroporation comprend une alimentation en CC et un générateur d'impulsions en C). L'alimentation en CC peut comprendre Un convertisseur CC-CC pour la conversion ascendante d'une sortie de tension par une alimentation en tension réglable. Chaque impulsion CC peut avoir une durée comprise entre 1 ns et 10 ms et une amplitude maximale dans la plage de 10 V À 10 kV.
Patent CA-3088411-A1 (CA)
Title: Humidifier for a fan coil
Inventor: CONRAD WAYNE ERNEST
IPC: F24F1/0087
Filed: 2020-07-29
Abstract: A fan coil has a heat exchanger and a humidification unit. An upstream temperature sensor is provided in the air flow path upstream of the heat exchanger and a downstream temperature sensor is provided in the air flow path downstream of the heat exchanger. A controller is operably connected to the humidification unit wherein, in operation, the controller receives an upstream signal from the upstream temperature sensor and a downstream signal from the downstream temperature sensor. Upon the controller determining that the fan coil is in a heating mode based on the upstream and downstream signals the controller activates the humidification unit
Patent CA-3088803-A1 (CA)
Inventor: SCHEDLBAUER MICHAEL
IPC: G06Q10/08
Filed: 2019-01-15
Abstract: L'invention concerne un système de préparation de commandes (1) servant à préparer des marchandises (2a, 2b). Le système de préparation de commandes comprend une zone de réception de marchandises (A1), une zone de transfert de marchandises, une zone d'entreposage (B1, B2), un système technique de manutention pour l'entreposage (3), un calculateur de commandes servant à détecter une commande de préparation et un système technique de manutention de sortie de l'entrepôt. Le système technique de manutention pour l'entreposage (3) et/ou le système technique de manutention de sortie de l'entrepôt comportent une pluralité de véhicules de manutention (5a - 5d) autonomes servant au transport des marchandises (2a, 2b) / des marchandises commandées sur une surface de circulation. La surface de circulation est divisée en plusieurs segments (E1, E3) de surface de circulation. Des déplacements sont coordonnés de telle sorte que les déplacements dans les segments (E1, E3) de surfaces de circulation sont effectués respectivement au moins à hauteur de 90 % d'un groupe fermé de véhicules de manutention (5a - 5d) autonomes. L'invention concerne par ailleurs un procédé servant à faire fonctionner le système de préparation de commandes (1).
Patent CA-3088993-A1 (CA)
Inventor: MASTEK WITOLD
IPC: F27B3/18
Filed: 2019-01-16
Abstract: A furnace system (12) includes a mixing chamber (17) that receives separate streams of raw material and cullet mix and discharges a combined stream. The mixing chamber tapers from an inlet end (24) to an outlet end (26). One inlet (36, 38) in the inlet end is configured to receive one of the material and mix and is aligned with an outlet (40) in the outlet end along a vertical axis (42). Another inlet (36, 38) is configured to receive the other of the material and mix and is offset from the outlet relative to the vertical axis such the material or mix is deposited on a sidewall of the tapered chamber before reaching the outlet. A charger (18) receives the combined stream from the mixing chamber and discharges the mixture into a molten bath in a furnace (12). A duct system (20) may be used to mix exhaust from the furnace with exhaust from the mixing chamber and charger.
Patent CA-3089900-A1 (CA)
Title: Self-cleaning catheter systems
Inventor: SAMOOCHA OR
IPC: B08B9/04
Filed: 2019-01-31
Abstract: Disclosed is a self-cleaning catheter system for fluid passage including a catheter, configured to be implanted in a body cavity of a subject and including at least one aperture fluidly coupling the catheter to the outside thereof, a cleaning unit configured for motion in the catheter such as to at least one of mechanically prevent, remove and mitigate occlusion in the at least one aperture, and an implantable controller. The cleaning unit is functionally associated with the controller, which is configured to (i) receive at least one signal indicative of a state of occlusion in the catheter, and (ii) provide an indication of the state of occlusion at least if the at least one signal indicates a blockage in the catheter and/or (iii) activate the cleaning unit if the at least one signal indicates a blockage of the catheter.
Patent CA-3090166-A1 (CA)
Inventor: GOODMAN BRIAN
IPC: C12M1/00
Filed: 2019-02-06
Abstract: Provided herein are methods and compositions related to Veillonella bacteria useful as therapeutic agents.