baber/WOPTO huggingface dataset:
Patent WO-2021242778-A1 (WO)
Title: Methods and compositions relating to engineered guide systems for adenosine deaminase acting on rna editing
Inventor: SAVVA YIANNIS
IPC: C12N15/11
Filed: 2021-05-25
Abstract: Provided herein are compositions of engineered guide RNAs relating to providing or engineering a structural target to attract adenosine deaminase acting on RNA (ADAR) editing to a desired site and methods of use thereof. Further provided herein are compositions and methods relating to recombinant adenosine deaminase acting on RNA (ADAR) split guide RNAs (adar-sgRNA). In certain embodiments, the adar-sgRNA composition comprises two guides-one guide with an ADAR recruiting domain and a second guide with a 5' and/or 3' RNA targeting domain for forming a trimolecular complex at a mismatch site that serves to recruit ADAR. Binding of the two adar-split gRNAs to the target RNA forms a trimolecular complex which recruits ADAR enzymes to deaminate one or more mismatched adenosine residues in the adar-split gRNA RNA targeting domain: target RNA duplex. In certain embodiments, such compositions and methods will be useful for modifying a coding sequence of a desired protein.
Patent WO-2021243259-A1 (WO)
Title: Hair growth compositions
Inventor: WALLER EDMUND
IPC: A61K8/9789
Filed: 2021-05-28
Abstract: The present application provides hair growth compositions, and more particularly compositions comprising  Portulaca Oleracea,  or an extract thereof, which may be useful in methods of treating hair loss and/or restoring hair color in a subject. Methods of treating hair loss and kits comprising the compositions are also provided.
Patent WO-2022203703-A1 (WO)
Inventor: MATSUNO KOICHI
IPC: H01L27/11548
Filed: 2021-05-28
Abstract: A semiconductor structure includes a semiconductor device, bit lines electrically connected to the semiconductor device, air gaps located between the bit lines, a capping-level material layer, a via-level dielectric material layer located between the bit lines and the capping-level material layer, and conductive via structures extending through the via-level dielectric material layer and contacting a top surface of a respective one of the bit lines. The capping-level material layer contains cavity-containing openings exposing the air gaps. The capping-level material layer contains protruding portions that extend into peripheral regions of the cavity-containing openings.
Patent WO-2021252537-A1 (WO)
Title: Additive manufacturing of polishing pads
Inventor: SRIDHAR UMA
IPC: B24B37/24
Filed: 2021-06-08
Abstract: Interpenetrating polymer networks (IPNs) for a forming polishing pad for a semiconductor fabrication operation are disclosed. Techniques for forming the polishing pads are provided. In an exemplary embodiment, a polishing pad includes an interpenetrating polymer network formed from a free-radically polymerized material and a cationically polymerized material.
Patent WO-2022026139-A1 (WO)
Inventor: QUIRK STEPHEN
IPC: C12N9/18
Filed: 2021-07-07
Abstract: A process and system are disclosed for increasing the rate of degradation of biopolymers in a solid waste depository, such as a landfill. A microorganism product, which can be an encapsulated product, is combined with the waste materials. The product contains one or more microorganisms that are designed to secrete an enzyme that degrades the biopolymer, which can be a polyhydroxybutyrate polymer. The microorganism can naturally secrete the enzyme or can be genetically modified to secrete the enzyme. The microorganisms or bacteria incorporated into the product are particularly selected in order to thrive in a particular environmental condition where the solid waste is located.
Patent WO-2022020653-A1 (WO)
Title: Frozen food product systems and methods
Inventor: COLLINS JOSEPH
IPC: A23G9/10
Filed: 2021-07-22
Abstract: A frozen food appliance and related method of making a frozen food product. A rotational drive assembly configured in an axial alignment using a direct drive to produce rotational movement of a blade element to contact a frozen food precursor in a frozen food container associated with the frozen food appliance where the rotational drive assembly omits rotational speed modifying gears and transmissions positioned between a drive motor and the blade element. In another aspect, a rotational drive assembly may be kept in axial alignment with a frozen food container via a multi portioned container mount having a float connector.
Patent WO-2022020734-A1 (WO)
Title: Device for non-invasively measuring glucose concentration
Inventor: GAL AVNER
IPC: A61B5/00
Filed: 2021-07-23
Abstract: Examples disclosed herein provide a combination of measurement channels each having a pair of measuring sub-channels. Each sub-channel measures the glucose concentration by monitoring a physical variable dependent on the glucose concentration in the subject's tissue. The subchannels of each measurement channel are orthogonal towards a common disturbance acting on each subchannel of the apparatus. Ultrasonic, electromagnetic, and thermal channels may be implemented. The non-invasive glucose monitor comprises a processing unit, which drives these sub-channels' sensors. The sensors may be located on a sensor unit configured as an ear clip. The sensor unit may include ultrasonic piezo transducers positioned on opposing portions of the ear clip and thus configured to be on opposite sides of the ear lobe, capacitor plates positioned on opposing portions of the ear clip, and a heater and a sensor positioned on the ear clip in close juxtaposition to the ear lobe.
Patent WO-2022066292-A1 (WO)
Title: Multibit multi-height cell to improve pin accessibility
Inventor: VANG FOUA
IPC: G06F30/394
Filed: 2021-08-04
Abstract: A MOS IC includes a MOS logic cell that includes first and second sets of transistor logic in first and second subcells, respectively. The first and second sets of transistor logic are functionally isolated from each other. The MOS logic cell includes a first set of M x  layer interconnects on an M x  layer extending in a first direction over the first and second subcells. A first subset of the first set of M x  layer interconnects is coupled to inputs/outputs of the first set of transistor logic in the first subcell and is unconnected to the second set of transistor logic. Each of the first subset of the first set of M x  layer interconnects extends from the corresponding input/output of the first set of transistor logic of the first subcell to the second subcell, and is the corresponding input/output of the first set of transistor logic.
Patent WO-2022032001-A1 (WO)
Title: Systems, methods, and computer programs, for analyzing images of a portion of a person to detect a severity of a medical condition
Inventor: JENKINS JULIAN
IPC: G06K9/00
Filed: 2021-08-05
Abstract: Methods, systems, and computer programs for monitoring skin condition of a person. In one aspect, a method can include obtaining data representing a first image, the first image depicting skin from at least a portion of a body of a person, generating a severity score that indicates a likelihood that the person is trending towards an increased severity of an auto-immune condition or trending towards a decreased severity of an auto-immune condition, comparing, the severity score to a historical severity score, wherein the historical severity score is indicative of a likelihood that a historical image of the user depicts skin of a person having the auto-immune condition, and determining based on the comparison, whether the person is trending towards an increased severity of the auto-immune condition or trending towards a decreased severity of the auto-immune condition.
Patent WO-2022051694-A1 (WO)
Title: Streamlined assay preparation
Inventor: REBER CLAY
IPC: B01L3/00
Filed: 2021-09-04
Abstract: The present disclosure provides assay and method for using assay for streamlined assay preparation and testing. These assay are useful for pathogen ( e.g.,  viral or bacterial) detection. The present disclosure also provides assay assemblies and means to prevent or minimize the formation of bubbles when using puncturing elements in fluidic devices or chambers.
Patent WO-2022060743-A1 (WO)
Title: Eyepieces for augmented reality display system
Inventor: LIU Victor Kai
IPC: G02B27/01
Filed: 2021-09-14
Abstract: An eyepiece waveguide for an augmented reality display system. The eyepiece waveguide can include an optically transmissive substrate with an input coupling grating (ICG) region. The ICG region can receive a beam of light and couple the beam into the substrate in a guided propagation mode. The eyepiece waveguide can also include a combined pupil expander-extractor (CPE) grating region that receives the beam of light from the ICG region and alters the propagation direction of the beam with a first interaction and out-couples the beam with a second interaction. The diffractive features of the CPE grating region can be arranged in rows and columns of alternating higher and lower quadrilateral surfaces or the diffractive features can comprise diamond shaped raised ridges. The eyepiece waveguide can also include one or more recycler grating regions.
Patent WO-2022060782-A1 (WO)
Title: Techniques for enhanced configured grant configuration
Inventor: KIM YUCHUL
IPC: H04W72/14
Filed: 2021-09-15
Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may determine a downlink configuration including a set of resources for receiving downlink transmissions. The UE may determine a grant for performing uplink transmissions based on a radio resource control (RRC) message. The UE may determine, based on the downlink configuration, the grant, or both, an uplink configuration including a set of resources for transmitting the uplink transmissions at a set of uplink transmission occasions. In some aspects, the set of uplink transmission occasions may be arranged according to a non-uniform spacing pattern in a time domain. The UE may transmit, to a base station, one or more uplink transmissions based on the uplink configuration.
Patent WO-2022066989-A1 (WO)
Inventor: HEGER JASON
IPC: G02B27/01
Filed: 2021-09-24
Abstract: Eyewear including a sensor integrated into frame of eyewear. In one example, the sensor comprises a strain gauge, such as a metallic foil gauge, that is configured to sense and measure distortion of the frame when worn by a user and under different force profiles, by measuring a strain in the frame when bent. The measured strain by strain gauge is sensed by a processor, and the processor performs dynamic calibration of image processing based on the measured strain. The distortion measured by the strain gauge is used by the processor to correct calibration of the cameras, and the displays.
Patent WO-2022103814-A1 (WO)
Inventor: CHIU DANIEL T
IPC: G01N15/00
Filed: 2021-11-10
Abstract: L'invention décrit des systèmes et des procédés permettant d'analyser des particules en écoulement dans un canal. Dans un mode de réalisation, le canal est conçu pour permettre l'écoulement d'une particule à travers une lumière du canal, le canal délimitant une fenêtre d'interrogation conçue pour permettre à une lumière de passer à l'intérieur et à l'extérieur de la lumière ; un moteur à lumière comprenant : une première source de lumière positionnée pour émettre une première lumière d'excitation sur une première partie du canal dans la fenêtre d'interrogation ; et une seconde source de lumière positionnée pour émettre une seconde lumière d'excitation sur une seconde partie du canal dans la fenêtre d'interrogation séparée de la première partie. Dans un mode de réalisation, les systèmes comprennent un faisceau de fibres d'émission comprenant une première fibre optique d'émission et une seconde fibre optique d'émission, une extrémité proximale de la première fibre optique d'émission et de la seconde fibre optique d'émission étant agencées en une tête de faisceau de fibres d'émission.
Patent WO-2022256043-A1 (WO)
Inventor: MCWAID THOMAS H
IPC: C25B9/19
Filed: 2021-12-22
Abstract: La présente invention concerne des ensembles bacs d'anode et/ou de cathode comprenant des configurations de nervures et de soudures uniques ; une cellule électrochimique et/ou un électrolyseur contenant les ensembles bacs d'anode et/ou de cathode ; et leurs procédés d'utilisation et de fabrication.
Patent WO-2021207768-A1 (WO)
Title: Custom text generation based on skill profile
Inventor: BLAU-MCCANDLISS VERA
IPC: G06F15/18
Filed: 2021-04-09
Abstract: A text generation machine performs a method of generating custom text. The text generation machine accesses a skill profile that specifies one or more skills of a user. The text generation machine determines a set of one or more words based on the one or more skills specified by the skill profile. The text generation machine then generates custom text for the user, and the generated custom text includes the determined set of words. The text generation machine then causes presentation of the generated custom text. A trainer machine performs a method of training a learning machine, based on one or more reference stories, to perform all or part of the method of generating custom text. The trained learning machine is configured to generate custom text based on one or more inputted words, which may be selected or otherwise determined based on a user's skill profile.
Patent WO-2021226621-A1 (WO)
Title: Apparatus that enables a leash to coil around an animal's collar
Inventor: WALTERS TYSON
IPC: A01K27/00
Filed: 2021-04-30
Abstract: Apparatus (10) to enable an elongate leash (12, 74) to coil, when not in use, around an animal's neck while attached to the animal's collar includes retainers (14, 14A, 14B, 14C, 14D, 14E, 90, 110) each including a polarized magnet (16, 78, 80, 82, 84) and first and second parts (18, 18A, 20, 20A, 92, 94) that have an at least partly separated state that enables placement of the leash (12) between the parts at any one of a plurality of different, user-selectable locations along a length of the leash (12) and an engaged state in which the parts are fixed to the leash at a user-selected location along the length of the leash (12). The retainers (14, 14A, 14B, 14C, 14D, 14E, 90, 110) are configured, with respect to the polarity of the magnets (16, 78, 80, 82, 84) therein, to enable them to magnetically couple to one another and provide the leash (12) with a coiled state around the animal's neck. The leash (12) has an extended, use state in which the magnets (16, 78, 80, 82, 84) in the retainers (14, 14A, 14B, 14C, 14D, 14E, 90, 110) are not magnetically coupled to one another.
Patent WO-2022155347-A1 (WO)
Inventor: Chuprakov Stepan
IPC: A61K31/4745
Filed: 2022-01-13
Abstract: La présente divulgation concerne des structures de conjugué anticorps-médicament (ADC), le conjugué anticorps-médicament comprenant une camptothécine ou un dérivé de camptothécine lié à un polypeptide (par exemple un anticorps) par l'intermédiaire d'un lieur. La divulgation concerne également des composés et des procédés pour la production de ces conjugués, ainsi que des méthodes d'utilisation des conjugués.
Patent WO-2022170057-A1 (WO)
Inventor: DUNPHY STEPHEN
IPC: A61B5/28
Filed: 2022-02-04
Abstract: L'invention concerne un vêtement pour électrocardiogramme (ECG) diagnostique pouvant être porté. Le vêtement pour ECG diagnostique pouvant être porté comprend un corps de vêtement (110), des électrodes sérigraphiées (115) positionné sur le corps (110), et des fils sérigraphiés positionnés dans le corps de vêtement (110), chacun des fils sérigraphiés (105) étant connecté d'un module de connecteur central (170) à une électrode sérigraphiée (115).
Patent WO-2022177944-A1 (WO)
Inventor: MORELLI MICHAEL V
IPC: G06T7/80
Filed: 2022-02-16
Abstract: Systems, methods, and computer-readable media are disclosed for characterizing LIDAR point cloud quality. An example method may involve capturing a first point cloud for a test target including a retroreflective object, the first point cloud including a first region. The example method may also involve capturing, by a LIDAR system, a second point cloud for the test target. The example method may also involve applying a penalty function to a first point in the second point cloud, wherein the first point is within an acceptable error threshold based on the first region. The example method may also involve applying a penalty function to a second point in the second point cloud, wherein the second point is outside of the acceptable error threshold based on the first region. The example method may also involve generating a first score for the first point and a second score for the second point based on the penalty function. The example method may also involve combining the first score and the second score to produce a point cloud quality metric for the second point cloud. The example method may also involve calibrating, based on the point cloud quality metric, the LIDAR system for the retroreflective object.
Patent WO-2022178166-A1 (WO)
Inventor: FORSYTH BRADLEY
IPC: A61M39/10
Filed: 2022-02-17
Abstract: Embodiments disclosed herein are directed to a coupling device including an invertible sleeve transitionable between a first, unlocked configuration and a second, locked configuration. A stem of the coupling device can be urged into a lumen of the catheter. A stem of a port can be urged into a lumen of the coupling device. The sleeve can be inverted from the unlocked configuration, where the sleeve extends distal ly, to a locked configuration where the sleeve extends proximally. The sleeve can fit tightly about a sleeve bearing portion of the port in the locked configuration to secure the port thereto. The sleeve can be formed of an elastic material to allow the sleeve to transition between the first stable configuration and the second stable configuration. Advantageously, the coupling device forms a continuous outer profile to mitigate tissue ingrowth.
Patent WO-2022192764-A1 (WO)
Title: Outdoor power equipment with convertible seated and standing operator positions
Inventor: KUCERA JEFF
IPC: A01D34/81
Filed: 2022-03-14
Abstract: An outdoor power equipment having sitting configuration and standing configuration is presented herein. The outdoor power equipment can be transformed from the sitting configuration to the standing configuration and vice versa, allowing an operator to use the outdoor power equipment in either a sitting position or standing position. The sitting position can place the operator at least in part forward of a drive axis of the outdoor power equipment, whereas the standing position can place the operator at least in part coincident with or behind the drive axis. The outdoor power equipment can be electric powered in some aspects, with modular and replaceable battery packs.
Patent WO-2022204553-A1 (WO)
Title: Systems and methods for a return manifold
Inventor: PETERSON TOM
IPC: E02F9/22
Filed: 2022-03-25
Abstract: A return manifold includes a housing having a first workport, a second workport, a third workport, and a fourth workport, and defining a first chamber and a second chamber. The return manifold includes a back-pressure disk arranged between the first workport and the first chamber, a bypass disk arranged between the first chamber and the second chamber, a back-pressure spring biased between the back-pressure disk and the bypass disk, and a bypass spring biased against the bypass disk. The back-pressure disk and the bypass disk are hydro-mechanically coupled so that movement of the bypass disk alters a force on the back-pressure disk and movement of the back-pressure disk alters a force on the bypass disk.
Patent WO-2022216584-A1 (WO)
Title: Peptide based vaccine generation system with dual projection generative adversarial networks
Inventor: MIN RENQIANG
IPC: G16B15/30
Filed: 2022-04-04
Abstract: A method is provided for generating new binding peptides to MHC proteins includes training (430), by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data including the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing (440) the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data. A second loss discriminating generated binding peptide sequences from non-binding peptide sequences in the training data.
Patent WO-2022226306-A1 (WO)
Title: Highly deformable porous membrane culture system and actuation methods for studying the effects of biomechanical stretch on cultured tissue
Inventor: ISENBERG BRETT
IPC: C12M1/00
Filed: 2022-04-22
Abstract: The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.
Patent WO-2022235749-A1 (WO)
Title: Electromechanical exercise machine
Inventor: FERLITO JOHNNY
IPC: A63B24/00
Filed: 2022-05-04
Abstract: An electro-mechanical displacement exercise apparatus for processing a maximum force potential of an athlete, including a frame a frame including a platform, wherein a section of the platform is connected to a tower, whereby the tower houses control means for manipulating a tension supporting member connected to a force bearing member, a first pull location, whereby the first pull location is positioned on the platform and within the frame and whereby the first pull location is operatively connected with a portion of the tension supporting member, whereby a user may exert a force on the tension supporting member operatively connected to a first actuator; and wherein the first actuator is housed within the tower, and whereby the first actuator includes a motor coupled to a gearbox.
Patent WO-2022245979-A1 (WO)
Title: Techniques de projection d'expression d'échantillon unique sur une cohorte d'expression séquencée à l'aide d'un autre protocole
Inventor: POSTOVALOVA EKATERINA
IPC: G16B25/10
Filed: 2022-05-18
Abstract: Selon des aspects, la divulgation concerne des procédés d'amélioration de la compatibilité de données de séquençage d'acide nucléique obtenues à l'aide de différentes techniques. La divulgation repose, en partie, sur des procédés de mappage de niveaux d'expression pour des gènes exprimés dans un échantillon biologique et obtenus à partir d'un sujet à l'aide d'un premier protocole sur des niveaux d'expression tels qu'ils auraient été déterminés par l'intermédiaire d'un second protocole si le second protocole avait été utilisé pour traiter l'échantillon biologique au lieu du premier protocole.
Patent WO-2023278834-A1 (WO)
Inventor: FLETCHER DANIEL
IPC: C12Q1/68
Filed: 2022-07-01
Abstract: La détection de gouttelettes d'ARN permet la quantification de la quantité absolue d'ARN cible ainsi que l'identification de différentes espèces de mutants ou de variants d'ARN. Comme décrit dans la description, la détection d'ARN avec une sensibilité élevée et une spécificité multiplexée peut être obtenue avec des temps de détection courts en encapsulant la réaction de Cas dans des gouttelettes et en surveillant la cinétique enzymatique par fluorescence.