Patent SG-11201903302U-A (SG)
Title: Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments
Inventor: BERNETT MATTHEW
IPC: C07K16/28
Filed: 2017-10-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111010111 01111101011H011111101111111101111101111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/071918 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: o Xencor, Inc., 111 West Lemon Avenue, Monrovia, CA C07K 14/54 (2006.01) C07K 16/28 (2006.01) 91016 (US). VARMA, Raj at; c/o Xencor, Inc., 111 West C07K 14/715 (2006.01) C07K 19/00 (2006.01) Lemon Avenue, Monrovia, CA 91016 (US). BONZON, (21) International Application Number: Christine; c/o Xencor, Inc., 111 West Lemon Avenue, PCT/US2017/056826 Monrovia, CA 91016 (US). (22) International Filing Date: (74) Agent: NG, Jennifer K. et al.; Morgan, Lewis & Bockius, 16 October 2017 (16.10.2017) LLP, One Market, Spear Street Tower, San Francisco, CA 94105 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/408,655 14 October 2016 (14.10.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/416,087 01 November 2016 (01.11.2016) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/443,465 06 January 2017 (06.01.2017) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/477,926 28 March 2017 (28.03.2017) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: XENCOR, INC. [US/US]; 111 West Lemon OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Avenue, Monrovia, CA 91016 (US). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: BERNETT, Matthew; c/o Xencor, Inc., 111 West Lemon Avenue, Monrovia, CA 91016 (US). (84) Designated States (unless otherwise indicated, for every RASHID, Rumana; c/o Xencor, Inc., 111 West Lemon Av- kind of regional protection available): ARIPO (BW, GH, enue, Monrovia, CA 91016 (US). DESJARLAIS, John; c/ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = Title: BISPECIFIC HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RALPHA FC-FUSION PROTEINS = (54) PD-1 ANTIBODY FRAGMENTS AND Figure 1 = = = RAW Pt = = = = _ common gamma =x, — 0334 = 1-1 HAS GC 11 0\ 11 IN 11:15Rutsusiti) © --.... 11 C:::: ) (57) : The present disclosure is directed to bispecific heterodimeric Fc fusion proteins comprising an IL-15/IL-15Ra Fc-fusion C protein and a PD-1 antibody fragment-Fc fusion protein. ei [Continued on next page] WO 2018/071918 Al MIDEDIMOMOIDEIREEMOMMOHHOHOMEEN UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))