baber/WOPTO huggingface dataset:
Patent JP-2021035511-A (JP)
Title: Wearable hemoperfusion device
Inventor: Robert s ward
IPC: A61M60/847
Filed: 2020-10-22
Abstract: To provide methods and devices for removal of toxins and pathogens from infected blood of patients.SOLUTION: A portable and/or wearable device 100 for extracorporeal removal of a toxin and/or pathogen from blood of an individual infected with the toxin and/or pathogen comprises a cartridge comprising an absorption medium 110, the absorption medium being a solid substrate of high surface area having at least one polysaccharide absorbent on the surface thereof with a binding affinity or binding site for the toxin and/or pathogen such that when flowing blood is in contact with the absorption medium, the toxin and/or pathogen bind to binding sites on the at least one polysaccharide absorbent and become separated from blood.SELECTED DRAWING: Figure 1
Patent JP-2022068937-A (JP)
Title: Sensor device and wearable device
Inventor: OISHI SADATOSHI
IPC: G04G17/00
Filed: 2020-10-23
Abstract: To provide a sensor device that extends the functions of a wearable device without impairing workability of a user.SOLUTION: A sensor device, together with a smart device and a band that enables the smart device to be worn on a forearm of a user, constitutes a wearable device. The sensor device includes: a first end portion arranged at a side of the hand of the user when the wearable device is worn; a second end portion arranged at a side of the elbow of the user when the wearable device is worn; and an attachment portion to be attached to the band, the attachment portion being offset to the side of the first end portion, relative to a midpoint position positioned at the midpoint between the first end portion and the second end portion.SELECTED DRAWING: Figure 1
Patent JP-2022071478-A (JP)
Title: Control system
Inventor: OSADA TAKASHI
IPC: E06B9/68
Filed: 2020-10-28
Abstract: To provide a control system allowing safety of an opening and closing device in use to be increased.SOLUTION: A control system 50 has an opening operation section 61, which transmits an opening signal when receiving an opening operation input in a non-contact manner, a closing operation section 62, which transmits a closing signal when receiving a closing operation input in a non-contact manner, a stop operation section 63, which transmits a stop signal when receiving a stop operation input in contact or non-contact manner, and an opening and closing movement control section that controls opening and closing movement of an opening and closing body 30 based on a signal received from the opening operation section 61, the closing operation section 62 or the stop operation section 63. The stop response time is shorter than an opening response time and shorter than a closing response time.SELECTED DRAWING: Figure 1
Patent JP-2022071612-A (JP)
Title: Protective structure for humidifier
Inventor: KAJIO KATSUHIRO
IPC: H01M8/04
Filed: 2020-10-28
Abstract: To provide a protective structure for a humidifier which protects the humidifier disposed on an end plate.SOLUTION: In a fuel battery system, a humidifier 25 for humidifying oxidant gas to be supplied to a fuel battery 1 is provided on an outer face of an end plate 2 for integrating a plurality of fuel battery cells 1a of the fuel battery 1, and a protective member F covering the outer periphery of the humidifier 25 is fitted integrally with the humidifier 25. Further, the humidifier 25 has a plurality of separators 25a which feed the unreacted oxidant gas to be supplied to the fuel battery 1 with water contained in the oxidant gas that has been discharged from the fuel battery 1 after a reaction. The plurality of separators 25a are disposed on the outer face of the end plate 2 in a laminated state.SELECTED DRAWING: Figure 3
Patent JP-2021041179-A (JP)
Title: System for collecting vascular data
Inventor: EUGEN VESZELEI
IPC: A61B5/0215
Filed: 2020-11-02
Abstract: To provide a system for collecting vascular data.SOLUTION: A system 10 for collecting vascular data comprises one or more memory devices and a computing device. The memory devices include instructions executable by the computing device, the instructions making the computing device: during a period in which an intravascular probe of a guide wire type 40 is positioned in a blood vessel, apply constant excitation voltage to the probe so as to heat a temperature sensitive resistor of the prove to a temperature equal to or higher than that of blood in the blood vessel; during a period in which the constant excitation voltage is applied, receive temperature sensitive resistor data on the basis of an electric signal associated with the temperature sensitive resistor; determine a transfer function using recorded guide wire type intravascular probe data; and calculate an intravascular flow rate value on the basis of the received temperature sensitive resistor data and the determined transfer function.SELECTED DRAWING: Figure 1A
Patent JP-2022074876-A (JP)
Title: Computer system, data structure, and program
Inventor: ARAI SHOKI
IPC: G08G1/00
Filed: 2020-11-05
Abstract: To appropriately anonymize a travel route of a user.SOLUTION: A computer system includes a processor. The processor generates abstract path data by abstracting original path data indicating a travel path of a user, based on map data that indicates a combination of a map element and an abstraction flag indicating whether to abstract path data.SELECTED DRAWING: Figure 3
Patent JP-2022075225-A (JP)
Title: Control device, control method and electric vehicle
Inventor: ARIGA NOBUYUKI
IPC: B60L58/13
Filed: 2020-11-06
Abstract: To provide a technique capable of improving energy efficiency of travel while suppressing hunting of control.SOLUTION: An electric vehicle 1 can travel in a plurality of travel modes including a first travel mode and a second travel mode that uses a less amount of power of a capacitor 101 than the first travel mode. A management ECU 125 creates a travel plan 56 in which any of the plurality of travel modes is allocated to each of travel sections 52 of a travel planned route to a destination from a current location of the electric vehicle 1 and controls the travel mode of the electric vehicle 1. The management ECU 125, when a total estimation value of the power amount required for the travel of the travel section 52 in the first travel mode exceeds a current SOC 51, extracts a section in which an output estimation value 54 exceeds a second prescribed value 54a as a planned object section from the travel section 52, and allocates the second travel mode preferentially to a section farther from the electric vehicle 1.SELECTED DRAWING: Figure 4
Patent JP-2022076202-A (JP)
Title: Image processing apparatus and image processing system
Inventor: LINNELL GUMABACK
IPC: B41J29/38
Filed: 2020-11-09
Abstract: To permit only a specific user to output a sheet on which personal information on a certain user is written.SOLUTION: An image processing apparatus comprises: an operation panel; a reading unit that reads a sheet whose entry columns are not filled in; and a control unit that generates output data of a filled-in sheet. The operation panel receives registration of a permitted user from a registered user who has registered their personal information. The control unit sets a registered user as a candidate who has registered a job request user as a permitted user, causes the operation panel to receive designation of any one registered user who is set as the candidate, recognizes the designated registered user as a target user, and generates output data of a filled-in sheet in which personal information on the target user is written in entry columns.SELECTED DRAWING: Figure 6
Patent JP-2021020131-A (JP)
Title: Game machine
Inventor: HOSHI TAKASHI
IPC: A63F5/04
Filed: 2020-11-09
Abstract: To provide a game machine capable of increasing a vacant capacity of ROM of a main control circuit by reducing a capacity of a processing program or the like managed by the main control circuit, and increasing game properties by using the increased vacant capacity.SOLUTION: An out-of-regulation ROM area stores port output processing performing port output of on data or off data, on data output processing outputting on data of a stoppable signal from the port output processing when rotation of a symbol reaches prescribed fixed speed, and off data output processing outputting processing data of the stoppable signal from the port output processing on the basis that stop operation is detected after the on data is outputted. In the on data output processing and the off data output processing, the port output processing is called after all register values of a plurality of general-purpose registers are evacuated to a stack area of the out-of-regulation RAM area, and then all the register values are shifted to a program stored to a game ROM area after they are restored to a plurality of general-purpose registers.SELECTED DRAWING: Figure 138
Patent JP-2022077842-A (JP)
Title: Scheduler, program and information processing method
Inventor: YOSHIDA TAKETOSHI
IPC: G06F3/06
Filed: 2020-11-12
Abstract: To improve reading performance of a tape storage.SOLUTION: A scheduler that controls a reading order of an object in a tape storage, selects a reading order B2 in which an integrated speed calculated based on a distance between objects and a travel speed is maximized for a reading request in which a plurality of laps having different travel directions are mixed.SELECTED DRAWING: Figure 2
Patent JP-2022077845-A (JP)
Title: Holder for skiving process
Inventor: UENO TERUAKI
IPC: B23F5/16
Filed: 2020-11-12
Abstract: To improve tooth surface accuracy in a skiving process.SOLUTION: A holder 1 for skiving process includes: a cutter portion 11 provided with a cutting surface in a leading-end direction; a holder 12 formed extending from the leading-end direction to a trailing-end direction, a leading-end direction side of which is connected to the cutter portion 11, and has an outer peripheral surface around an axis using an extending direction as an axial direction; and a support claw 13 one end of which is connected to the outer peripheral surface of the holder 12 and the other end of which is connected to a trailing-end surface 21b of the cutter portion 11. Thus, it is possible to suppress deflection and vibration of the cutter portion during processing.SELECTED DRAWING: Figure 1
Patent JP-2021079099-A (JP)
Title: Method for finding abnormal activation in intra-cardiac electrocardiograms
Inventor: ELIYAHU RAVUNA
IPC: A61B5/346
Filed: 2020-11-13
Abstract: To provide systems, apparatuses and methods for detecting abnormal intra-cardiac activity.SOLUTION: Methods, apparatus and systems for medical procedures are disclosed herein and include detecting points of an intra-cardiac area that exhibits abnormal activation, such as local abnormal ventricular activation (LAVA). Points that exhibit such abnormal activation may be referred to as seed points that are identified during a first step of a process disclosed herein. The seed points may be identified using one or more inputs such as unipolar and bipolar mapping channels, body surface ECGs, past activation and neighboring points during the first step which prioritizes high specificity over sensitivity. The seed points may be identified using one or more inputs such as unipolar and bipolar mapping channels, body surface ECGs, past activation and neighboring points during the first step which prioritizes high specificity over sensitivity.SELECTED DRAWING: Figure 1
Patent JP-2022080678-A (JP)
Title: Information providing method and information providing system
Inventor: SAKUMA TAKESHI
IPC: G08G1/09
Filed: 2020-11-18
Abstract: To provide an information providing method capable of providing information while reducing a content to the level required by a driver, etc., and an information providing system.SOLUTION: The present invention relates to an information providing method executed by a vehicle and including: acquiring road traffic information which is traffic related information displayed on a road where an own vehicle which is the vehicle travels; and providing the acquired road traffic information to an occupant of the own vehicle. The information providing method includes: estimating the necessity to provide the road traffic information to the occupant; determining a detail level determining the level of details in a content of the road traffic information to be provided on the basis of the estimated necessity; and providing the road traffic information to the occupant in accordance with the determined detail level and in a form predetermined for each detail level.SELECTED DRAWING: Figure 10
Patent JP-2022081342-A (JP)
Title: Glasses-type information appliance, method for the same, and program
Inventor: KANEKO TAKESHI
IPC: G06F3/01
Filed: 2020-11-19
Abstract: To solve the problem in which: conventionally, there is not provided an appropriate notification method according to the state of smart glasses and including the other wearable terminal.SOLUTION: In a glasses-type information appliance of the present invention, when there is notification from an application, if the glasses-type information appliance is not being used, the notification is transferred to the other wearable terminal, and display control for projecting the notification in a user's field of view is not executed.SELECTED DRAWING: Figure 4
Patent JP-2021042225-A (JP)
Title: Antigen-binding molecule that makes associated antigen disappear
Inventor: IGAWA TOMOYUKI
IPC: C12N15/10
Filed: 2020-11-20
Abstract: To provide an antigen-binding molecule that can make an associated body of protein disappear from plasma preferentially to a monomer.SOLUTION: An antigen-binding molecule that can make an associated body of protein disappear from plasma preferentially to a monomer by allowing an antigen-binding molecule which binds to an antigen forming an associated body to contain an antigen-binding domain and an Fc region whose binding activity to the antigen changes depending on the condition of ion concentration. Using the antigen-binding molecule makes it possible to treat various types of disease originated from target tissue specifically to the target tissue. Using the antigen-binding molecule makes it possible to treat diseases caused by an associated body of protein.SELECTED DRAWING: None
Patent JP-2021061002-A (JP)
Title: output method
Inventor: KANO NAOYUKI
IPC: B41J29/38
Filed: 2020-11-26
Abstract: To provide an output method for outputting, with an image forming apparatus, output data corresponding to data attached to a message posted on a messaging service.SOLUTION: An output method for receiving output data corresponding to acquired identification information from a server and outputting an image based on the output data from an image forming apparatus, and includes the steps of: receiving posting of a message to a messaging service from a terminal device; when the message includes attached data, transmitting the attached data to the server; and when the attached data is in a form allowing reception of registration, issuing the identification information corresponding to the output data based on the attached data.SELECTED DRAWING: Figure 7
Patent JP-2022091612-A (JP)
Title: Information processing device, matching program and matching method
Inventor: HATANAKA TAKESHI
IPC: G06T7/00
Filed: 2020-12-09
Abstract: To accurately match face information recognized by face recognition and posture information estimated by posture estimation with respect to an image on which a plurality of persons are reflected.SOLUTION: An information processing device 1 detects a face of each person from a captured image including a plurality of persons, and detects a person from the captured image. The information processing device 1 estimates a posture from the captured image on the basis of person detection data for every piece of person detection data corresponding to the plurality of detected persons. The information processing device 1 calculates face candidate data from skeleton information based on posture data for the estimated posture. The information processing device 1 identifies face detection data with the largest overlap area among pieces of face detection data of each detected person as the same person with respect to the face candidate data to be calculated for every piece of person detection data.SELECTED DRAWING: Figure 1
Patent JP-2021101607-A (JP)
Title: Vehicle power supply assembly
Inventor: JEFFREY JOHN WOLFF
IPC: H01F17/04
Filed: 2020-12-17
Abstract: To provide a power supply assembly for a vehicle, which further reduces size, weight, and cost, including a fan or the like for cooling an inductor used for filtering current received from an outside current source.SOLUTION: A trolley assembly 100 includes a pantograph 106 having: a mast 110 configured to couple with a vehicle such that the mast projects upwardly from a main body 108 of a vehicle 102; and a collection arm 112 configured to be coupled with the mast in a location apart from the vehicle in order to engage an external current source 114 outside the vehicle while the vehicle moves along one or more routes. One or more of the mast or the collection arm is formed from at least one inductive support member that provides an integrated inductor of the one or more of the mast or the collection arm. Through the integrated inductor, at least a part of electric current that is received from the external current source is filtered prior to being conducted to the vehicle.SELECTED DRAWING: Figure 1
Patent JP-2022097947-A (JP)
Title: mask
Inventor: HIGO HIROYUKI
IPC: A41D13/11
Filed: 2020-12-21
Abstract: To provide a mask.SOLUTION: A mask 1 includes: a body part 10 which is formed of sheet-like surface parts 11 and 12, and sheet-like back face parts 13 and 14 overlapped with the surface parts, and covers a wearer's face; a support part 20 which is attached to the body part and supports the body part on the wearer's face; an ornament part 30 which is suspended from the surface parts 11 and 12 and decorates the body part with an ornament 31; and a shielding part 40 which is attached to the surface part and shields a suspending part 32 for suspending the ornament 31. In the mask 1, the expensive ornament part 30 is firmly suspended from the body part 10 and the shielding part 40 shields the suspending part 32. Thus, the ornament by the ornament part becomes conspicuous and design improves.SELECTED DRAWING: Figure 1
Patent JP-2022104185-A (JP)
Title: Work machine
Inventor: NOSAKA KENKICHI
IPC: A01B49/04
Filed: 2020-12-28
Abstract: To provide a work machine capable of covering with soil a mulch film covering a top surface of a ridge.SOLUTION: A work machine 1 comprises: a plowing part 18 that rotates around a shaft 16 extending in a machine width direction K2 to plow a farm field; a ridge formation device A for forming a ridge UN on the farm field plowed by the plowing part 18; a mulch film laying part 300B for laying a mulch film 300F on the ridge UN; and an earthing-up member D for moving soil on the mulch film 300F. The earthing-up member D includes: a soil covering member DS for covering an end of the mulch film 300F with soil; and a blade BL that is disposed on an inner side in the machine width direction K2 of the soil covering member DS and guides the soil with which the end is covered onto the mulch film 300F covering a top surface of the ridge UN. The blade BL is configured separately from the soil covering member DS, is disposed so as to be tilted with respect to the soil covering member DS in a plan view, and extends inward in the machine width direction K2.SELECTED DRAWING: Figure 12
Patent JP-2020526879-A (JP)
Title: 独立して圧力および流量を調節する電子顕微鏡試料ホルダーの流体取扱方法
IPC: H01J37/26
Filed: 2018-07-06
Abstract: 電子顕微鏡試料ホルダーを通る気体に依存しない圧力および流量調節のための流体計測システムは、気体を供給する圧力調節装置と、圧力調節装置から試料ホルダーに気体を供給する流入管路と、試料ホルダーから気体を受け入れる流出管路と、流出管路内の気体の流量を調節する可変の漏出弁とを含む。気体は圧力調節装置の上流タンクから試料ホルダーおよび可変の漏出弁を通って圧力調節装置の下流タンクに流れ、これは可変の漏出弁が流出管路内の流量を計測するときの２つのタンクの圧力差に起因する。流量は、気体に依存しない圧力計を用いて、既知の体積の供給源タンクおよび採集タンクにおける圧力変化を監視することによってなされる。気体の流量を残留気体分析計（ＲＧＡ）に導く方法も提示する。
Patent JP-2020529167-A (JP)
Title: ネットワークハンドオーバ方法、装置、およびシステム
IPC: H04W48/18
Filed: 2018-07-16
Abstract: 本開示の実施形態では、ネットワークハンドオーバ方法、装置、およびシステムが開示される。この方法は、ユーザ機器（ＵＥ）に接続されたソース基地局に、ＵＥのためのトラフィックの確立中にハンドオーバを開始するように命令する第１ネットワーク要素と、ＵＥが第１アクセスネットワークから第２アクセスネットワークにハンドオーバされた後に、ベアラ確立またはサービス品質（ＱｏＳ）フロー確立を開始する第２ネットワーク要素とを含む。本開示の実施形態により、従来技術におけるネットワーク間のオーバー複雑なハンドオーバーの技術的課題が解決される。【選択図】図７
Patent JP-2020529892-A (JP)
Title: 能動的骨および関節安定化デバイス特徴
IPC: A61B17/68
Filed: 2018-07-11
Abstract: 骨および関節安定化デバイスまたはシステムのための構成要素、ならびに製造もしくは組立、および／または使用の関連付けられる方法が、説明される。構成要素は、遠位アンカフットまたはねじ山付きねじを伸長ばねタイプ部材に取り付ける、デバイス導入のための特徴、ヘッド内に係合されているときに伸長部材の位置を安定化させるためのアンカヘッド特徴、および／または主題デバイスを引張するためのデジタルまたは電子的方法を含む。
Patent JP-2020533281-A (JP)
Title: デキストラン硫酸の新規使用
IPC: A61P25/00
Filed: 2018-09-07
Abstract: デキストラン硫酸、またはその薬学的に許容可能な誘導体が、グリア細胞およびニューロンの分化を誘導するために使用される。デキストラン硫酸の細胞分化誘導は、神経変性疾患、脱髄性疾患、神経虚血性疾患および神経筋疾患を含む神経疾患を罹患している対象に対し好ましい効果を有する。【選択図】図１２
Patent JP-2020529190-A (JP)
Title: 電気機械式駆動システム
IPC: H02K53/00
Filed: 2018-06-22
Abstract: 本発明は、機械的な動力負荷(２)に対する電気機械式駆動システム（１）に関する。このシステムは、電源（４）に接続可能な電気モータ（３）と、一方で電気モータのシャフト（７）の第一端部（６）に接続され、他方で負荷（２）に接続可能な第一変速装置（６）と、発電機（８）と、一方で、電気モータ（３）のシャフトの第一端部（７）の方向と反対方向に延びる電気モータのシャフトの第二端部（１０）に接続され、かつ、他方で発電機（８）に接続される第二変速装置（９）とを備え、発電機（８）が、第二スイッチ（１１）を介して電源（４）及び電気モータ（３）に電気的に接続可能であり、発電機（８）からの電流を、電源（４）又は電気モータ（３）に向けることができるように構成され、機械的動力の負荷の必要性が低減した時に電源を充電するように構成されている。【選択図】 図１
Patent JP-2021500344-A (JP)
Title: 農薬としてのベンゾイミダゾール化合物
IPC: C07D401/14
Filed: 2018-10-17
Abstract: 本発明は、農業分野で殺菌剤として有用な下記式（I）の置換ベンゾイミダゾールおよび関連化合物に関する。【化１】
Patent JP-2021501888-A (JP)
Title: 動く物体のｐｅｔデータの減衰補正
IPC: G01T1/161
Filed: 2018-11-07
Abstract: 本発明は、動く物体２のゲーテッドＰＥＴデータの減衰補正を支援するシステム及び方法に関する。このシステムでは、評価ユニット１５が、（ｉ）物体２のＣＴ画像を受け取り、ＣＴ画像を撮像ボリュームの軸方向セグメントにそれぞれ対応する複数のＣＴサブ画像にセグメント化し、（ｉｉ）各ＣＴサブ画像について、ＣＴサブ画像と最大の対応度を有するＰＥＴデータを含むゲートを決定し、（ｉｉｉ）各ＣＴサブ画像について、ＣＴサブ画像に対して決定されたゲートに含まれるＰＥＴデータから、ＣＴサブ画像と同じ撮像ボリュームの軸方向セグメントに実質的に対応するＰＥＴサブ画像を作成し、（ｉｖ）ＰＥＴサブ画像を結合して、物体２のＰＥＴ基準画像を形成する。
Patent JP-2021501019-A (JP)
Title: 注射デバイス
IPC: A61M5/315
Filed: 2018-10-30
Abstract: 注射デバイスであって：薬剤カートリッジを受け入れるためのハウジングと；針を含む針ユニットと；ハウジングの長手方向軸に沿って、第１のスリーブが針を隠す第１の位置から、針が第１のスリーブの端部から露出される第２の位置に摺動可能な第１のスリーブとを含み、第１のスリーブは、針ユニットに係合するように構成され、それにより、使用中、第１の位置から第２の位置への第１のスリーブの移動により針ユニットが一次位置から二次位置に移動し、二次位置で、針ユニットは、薬剤カートリッジがデバイス内に受け入れられるときに薬剤カートリッジの端部に被さって位置し、デバイスは、第１のスリーブに対して嵌め込み式で移動するように配置された第２のスリーブをさらに含み、第１のスリーブは、第１のスリーブが第１の位置にあるときに第２のスリーブから延びる、注射デバイス。 【選択図】図２
Patent JP-2021503825-A (JP)
Title: 超高信頼低レイテンシ通信のためのポーラコードのハイブリッド自動再送要求設計のための技法および装置
IPC: H04L1/00
Filed: 2018-10-02
Abstract: 本開示の様々な態様は、一般に、ワイヤレス通信に関する。いくつかの態様では、ワイヤレス通信デバイスは、ポーラコーディング技法を使用して符号化される通信の第1の送信を実行することと、通信の少なくとも1つの再送信を実行することであって、より多くのリソースが、第1の送信に対してよりも、少なくとも1つの再送信に対して割り振られ、少なくとも1つの再送信が、通信の増分冗長バージョンおよびチェイス合成のための通信のバージョンを含む、こととを行い得る。多数の他の態様が提供される。
Patent JP-2021503693-A (JP)
Title: バーコリメータ、バックライトシステム、および方法
IPC: F21S2/00
Filed: 2017-11-18
Abstract: バーコリメータおよびバックライトシステムは、バックライトを照らすためのコリメート光を提供する。バーコリメータは、導波光として光を導波するように構成された光導波路と、光導波路からの導波光の一部を抽出光として散乱させるように構成された、光導波路の側の光抽出機能部とを含む。バーコリメータは、光導波路とバックライトとの間にコリメートフィルムをさらに含み、コリメートフィルムは、抽出光をコリメートするように構成されている。コリメート光は、バックライトの入力部の長さに対応する範囲を有し、バックライトの照明光源として機能するように構成されている。バックライトシステムは、バーコリメータおよびバックライトを含む。バックライトは、マルチビューバックライトであってもよい。
Patent JP-2021505075-A (JP)
Title: 帯域幅が重なっていないカスケーディング・マルチパス干渉ジョセフソン方向性増幅器を使用した周波数多重化マイクロ波信号の選択的増幅
IPC: G06N10/00
Filed: 2018-01-05
Abstract: 【課題】カスケーディング選択的マイクロ波方向性増幅器、カスケーディング選択的マイクロ波方向性増幅器を形成する方法および超電導体製造システムを提供する。【解決手段】カスケーディング選択的マイクロ波方向性増幅器（カスケード）は、ジョセフソン・デバイスのセットを含み、このセットの中のそれぞれのジョセフソン・デバイスは、対応するマイクロ波周波数動作帯域幅を有する。異なる動作帯域幅は、対応する異なる中心周波数を有する。このセットの中の第１のジョセフソン・デバイスとこのセットの中のｎ番目のジョセフソン・デバイスとの間に、直列結合が形成されている。この直列結合により、第１のジョセフソン・デバイスは、直列結合内の第１の信号流れ方向において、周波数多重化マイクロ波信号（多重化信号）の中の第１の周波数の信号を増幅し、ｎ番目のジョセフソン・デバイスは、直列内の第２の信号流れ方向において、ｎ番目の周波数の信号を増幅し、第２の信号流れ方向は第１の信号流れ方向とは反対である。【選択図】図１
Patent JP-2020534030-A (JP)
Title: トランスグルタミナーゼコンジュゲーション方法およびリンカー
IPC: A61K38/19
Filed: 2018-09-19
Abstract: 本発明は、微生物トランスグルタミナーゼ（ＭＴＧ）を用いて、抗体−ペイロードコンジュゲートを生成する方法に関する。この方法は、第一級アミン残基を有するリンカーであって、ペプチド構造（ＮからＣの方向に示す）（Ａａｘ）ｍ−（Ａａｘ）（ＮＨ２）−（Ａａｘ）ｎ−Ｂ−（Ａａｘ）ｏ、または（Ａａｘ）ｍ−Ｂ−（Ａａｘ）ｎ−（Ａａｘ）（ＮＨ２）−（Ａａｘ）ｏを有するリンカーを、抗体の重鎖または軽鎖に含まれるＧｌｎ残基にコンジュゲートするステップを含む。Ａａｘ（ＮＨ２）は、第一級アミン基を有する側鎖を含む、アミノ酸、アミノ酸誘導体、またはアミノ酸ミメティックである（図１）。