baber/WOPTO huggingface dataset:
Patent DE-69612022-T2 (DE)
Inventor: LESIEUR DANIEL
IPC: A61P25/26
Filed: 1996-01-10
Granted: 2001-09-20
Abstract: Hetero-cycloalkyl derivs. of formula (I) and their enantiomers and diastereoisomers are new. R1 = alkyl opt. substd. by Q; or cycloalkyl or cycloalkylalkyl, both opt. substd. by Q'; A together with the benzene gp. = tetrahydronaphthalene, dihydronaphthalene, naphthalene, benzothiophene, 2,3-dihydrobenzothiophene; or indoline or indole both opt. N-substd. by Ra, CORa or CO2Ra; Ra = alkyl, Ph or phenylalkyl; R2 = H or alkyl; R3 = C(=X)R4 or C(=X')NHR5; X, X' = S or O; R4 = H, alkenyl, alkynyl, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; R5 = H, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; alkyl, alkoxy = 1-6C; alkenyl, alkynyl = 2-6C; cycloalkyl = 3-8C; Q = halo, OH, alkyl or alkoxy; Q' = halo, alkyl or oxo.
Patent DE-69623119-T2 (DE)
Inventor: PERKINS MARK
IPC: B01J31/18
Filed: 1996-06-04
Granted: 2003-04-24
Abstract: A method for manufacturing cobalt complexes having the formula:[Co(NH3)5M]Tywherein M ligands are selected from substituted and unsubstituted C1-C30 carboxylic acids having the formulas:RC(O)O-;said method comprising reacting cobalt complexes having the formula [Co(NH3)5X]Ty (e.g., X is chlorine) with concentrated ammonium hydroxide followed by carboxylic acid anhydride of the formula RC(O)O(O)CR.
Patent DE-69625678-T2 (DE)
Inventor: TAVTIGIAN SEAN V
IPC: C07K14/47
Filed: 1996-12-17
Granted: 2003-11-06
Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.
Patent DE-69629112-T2 (DE)
Inventor: STEC J
IPC: C07H19/10
Filed: 1996-05-24
Granted: 2004-04-22
Abstract: New organophosphorus mononucleoside derivatives, method of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleoside derivatives are provided. Synthesized organophosphorus mononucleoside derivatives of the present invention are characterized by formula (1). <CHEM> <IMAGE>
Patent DE-69631599-T2 (DE)
Inventor: MCINTOSH H
IPC: C08F4/605
Filed: 1996-11-07
Granted: 2004-12-16
Abstract: Silyl substituted polymers of polycycloolefins are provided as well as catalyst systems for their preparation. The polymers of the invention include polycyclic repeat units that contain pendant silyl functional groups represented by the following formulae: wherein A is a divalent radical selected from the following structures: R9 independently represents hydrogen, methyl, or ethyl; R10, R11, and R12 independently represent halogen, linear or branched (C1 to C20) alkyl, linear or branched (C1 to C20) alkoxy, linear or branched (C1 to C20) alkyl carbonyloxy, (C1 to C20) alkyl peroxy, and substituted or unsubstituted (C6 to C20) aryloxy; R10, R11, and R12 together with the silicon atom to which they are attached form the group: n is a number from 0 to 5; and n' is 0 or 1; and n'' is a number from 0 to 10.
Patent DE-69636824-T2 (DE)
Inventor: TUCKER MARJORIE M
IPC: A61L27/24
Filed: 1996-06-07
Granted: 2007-11-08
Abstract: Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma rays or an electron beam. The terminally sterilized devices of the invention are characterized in that they induce bone formation following implantation into a mammal. Also disclosed is a method for inducing bone formation in a mammal by implanting a terminally sterilized device of the invention into a preselected locus in a mammal. Also disclosed is a method for preparing the terminally sterilized device of the invention.
Patent DE-69700301-T2 (DE)
Inventor: PEREGO LUCIANO
IPC: B29C65/48
Filed: 1997-03-17
Granted: 1999-11-04
Abstract: The described device comprises a main support (2) on which a first disc half (3) is arranged, in an elastic-deformation condition according to which the disc half takes an inverted-cone conformation. A second disc half (14), optionally resiliently deformed to a conical configuration, is arranged under an auxiliary support (11) axially opposed to the main support (2). An adhesive dispenser (21) delivers glue for distributing it along the outer circumferential edge (3b) of the first disc half (3), following a rotation imparted to dispenser (21) or disc half (3b) about the respective axis. The dispensed adhesive runs down by gravity along the surface (3a) of the disc half (3), evenly spreading thereon. The second disc half (14) is then lowered onto the first disc half (3) to achieve mutual pairing. <IMAGE>
Patent DE-69703241-T2 (DE)
Inventor: MUELLER ROLLAND
IPC: B60J10/00
Filed: 1997-07-08
Granted: 2001-05-17
Abstract: A method of assembling a belt-line window molding for a motor vehicle door comprising i) a main body including a resilient window sealing structure constructed and arranged to seal a gap between the motor vehicle door and the motor vehicle window, and a mounting structure constructed and arranged to mount the window molding on the motor vehicle door, the mounting structure including a rigid portion, and ii) a metal cover member having a channel configuration constructed and arranged to cover a portion of the mounting structure which is adapted to extend in overlying relation to an exterior surface of the door. The method comprises forming the main body by extrusion; placing one edge of the metal cover member in an edge receiving recess of the main body; pivoting the metal cover member generally about the one edge so as to cause an opposite edge of the metal cover member to engage the rigid portion of the mounting structure; forcing the opposite edge of the metal cover member to move in sliding engagement across the rigid portion; outwardly flexing the channel configuration of the metal cover member as a result of the cover member being forced to move in sliding engagement across the rigid portion; and inwardly flexing the cover member back towards its original configuration and into gripping engagement with the rigid portion to secure the cover member to the main body.
Patent DE-69710465-T2 (DE)
Inventor: MUNN ALFRED
IPC: G07D7/02
Filed: 1997-06-24
Granted: 2002-06-27
Abstract: Apparatus for monitoring a document (11) to determine the presence of an electrically conductive element (1a, 1b) on or in the document (1) as the document is fed along a path (2). The apparatus includes at least two detection systems (40, 41) laterally spaced apart with respect to the direction of movement of the document along the path. The detection systems include antennae (6, 7, 8, 9, 10) for generating and detecting signals which are modified in the presence of an electrically conductive element (1a, 1b). A control system (20) is connected to the detection systems (40, 41) for monitoring signals from the detection system. Furthermore, a document detector (42, 43) for each detection system (40, 41) is positioned upstream of and on the same side of the centre line of the document feed path (6) of the respective detection system (40, 41). Each document detector (43) is connected to the control system (20), with the control system (20) being responsive to signals from the document detectors (42, 43) to monitor the corresponding detection system (40, 41) in a predetermined manner. This takes account of a skew fed document (1) to indicate the presence of an electrically conductive element (1a, 1b) if the monitored signals satisfy predetermined conditions.
Patent DE-69730160-T2 (DE)
Inventor: JAMES JOSEPH E
IPC: F24H1/00
Filed: 1997-06-18
Granted: 2005-09-01
Abstract: A purge manifold assembly, which can be used in a gas purged immersion heater, includes a housing having a vessel wall having an aperture extending therethrough. A purge manifold is located adjacent the vessel wall. The purge manifold includes an aperture extending therethrough and colinear with the vessel wall aperture, a bore extending in the purge manifold, in a direction approximately normal to the purge manifold aperture, and a port communicating the bore with the purge manifold aperture. A fitting body extends into the vessel wall aperture and the purge manifold aperture. The fitting body includes a longitudinally extending through bore and a port communicating with the through bore. The port also communicates with the port of the purge manifold. In this way, a purge gas is allowed to flow through a sheath enclosing a heater wire held in the housing of the gas purged immersion heater.
Patent DE-69731540-T2 (DE)
Inventor: CASAS A
IPC: A61K35/74
Filed: 1997-06-03
Granted: 2005-10-27
Abstract: A therapeutic method of treating diarrhea of a patient, such as that caused by rotavirus in which a liquid suspension of one or more strains of Lactobacillus reuteni is administered to the patient. Preferably the L. reuteri is isolated from an animal of the same species as the animal to which the therapy is being given. Preferably at least about 107 cells of L. reuteri, and most preferably, at least 108 cells, are administrated per day, over a period of one to seven days, depending on the severity of the gastroenteritis. The result is a rapid, dramatic reduction in animal's diarrhea and vomiting, previously not found using other therapies.
Patent DE-69735553-T2 (DE)
Inventor: SCHULTZ ROGER
IPC: H04M3/00
Filed: 1997-12-16
Granted: 2006-12-28
Abstract: The present invention concerns a method and an apparatus for designing, providing and managing customer services in a telecommunications network. The services are handled in a separate service network, connected to the telecommunications network in a logical service means, for example an SCP in an intelligent network. The service network is based on existing and commonly available network resources, for example, the Internet. Also, existing and commonly available terminals, such as personal computers are used for handling the services.
Patent DE-69805639-T2 (DE)
Inventor: ROESGEN EMILE
IPC: B60C9/20
Filed: 1998-05-07
Granted: 2002-11-21
Abstract: A very light weight tire 10 has at least one radial ply 38 and a aramid belt structure 36, having two single cut belt layers 50,51 covered by an overlay 59 having cords 80 selected from the group of aramid, rayon, PEN, PET and PVA. The tire 10 has a very thin or reduced gauge (t) undertead 13. The tire 10 can be made having very low rolling resistance due to the combination of casing structure and the reduced rubber mass.
Patent DE-69810397-T2 (DE)
Inventor: BENGT GOERAN NILSSON
IPC: E05F15/12
Filed: 1998-05-28
Granted: 2003-08-21
Abstract: Arrangement for operating devices for mechanically operated doors with a driving mechanism and a manoeuvring mechanism including a rotatable device in the form of a cog wheel and a linear device furnished with cogs that interact with the cog wheel. The novel aspect is that two linear devices furnished with cogs are arranged with a distance between one another with the cog wheel between them, whereby the size of the cog wheel is adapted to this distance so that it is only able to engage with one row of cogs at a time, and that the cog wheel is mounted in a housing (17) that is displaceable relative to the frame on which the rows of cogs are mounted to allow the displacement of the cog wheel to engage in an operating position with one row of cogs at a time. <IMAGE>
Patent DE-69816300-T2 (DE)
Inventor: TOPOROV YOURI GENADIEVICH
IPC: A61N5/10
Filed: 1998-10-30
Granted: 2004-05-27
Abstract: The method comprises the steps of forming an elongated tubular metal casing 1. This elongated tubular metal casing 1 is then coiled. The coiled tubular casing 11 is filled with a material 9 capable to irradiate radioactive radiation. The material 9 is in liquid state with following crystallization in the coiled tubular casing 11. The filled coiled tubular casing 11 is then sealed at its ends 5. <IMAGE>
Patent DE-69830305-T2 (DE)
Inventor: DIME DAVID S
IPC: A61P23/02
Filed: 1998-02-19
Granted: 2006-02-02
Abstract: Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring moiety; L is a linking group; and D is a drug.
Patent DE-69835609-T2 (DE)
Inventor: SATOMI SUSUMU
IPC: A61K31/198
Filed: 1998-09-30
Granted: 2007-08-09
Abstract: Compositions that contain valine as an active ingredient but which are entirely free of other amino acids or substantially free of amino other acids as an active ingredient are used as drugs or foods for treating or ameliorating hepatic diseases, whereupon less side effects are caused than in the conventional regimens of pharmacotherapy and yet the compositions ameliorate, palliate or gain recovery from symptoms and abnormalities that are caused by such hepatic diseases, for example, fever, lassitude, loss of appetite, vomiting stomachache, ascites and pleural effusion, or complications of hepatic disease (not including hepatic encephalopathy).
Patent DE-69836271-T2 (DE)
Inventor: NESSETT M
IPC: G06F13/00
Filed: 1998-05-28
Granted: 2007-09-13
Abstract: A system provides for establishing security in a network that include nodes having security functions operating in multiple protocol layers. Multiple network devices, such as remote access equipment, routers, switches, repeaters and network cards having security functions are configured to contribute to implementation of distributed firewall functions in the network. By distributing firewall functionality throughout many layers of the network in a variety of network devices, a pervasive firewall is implemented. The pervasive, multilayer firewall includes a policy definition component that accepts policy data that defines how the firewall should behave. The policy definition component can be a centralized component, or a component that is distributed over the network. The multilayer firewall also includes a collection of network devices that are used to enforce the defined policy. The security functions operating in this collection of network devices across multiple protocol layers are coordinated by the policy definition component so that particular devices enforce that part of the policy pertinent to their part of the network.
Patent DE-69900597-T2 (DE)
Inventor: BESLER MARTIN
IPC: G02B6/42
Filed: 1999-03-02
Granted: 2002-08-01
Abstract: A connector is specified having a housing (1) with at least one holding shaft (2) for a complementary plug (3), the connector respectively having a spring arm (4) which bounds the holding shaft (2) on one side, presses on the corresponding side of the complementary plug (3) and locks the plug (3) there in its inserted position, and by a bow (5) as secondary locking mechanism, which holds the free end (6) of the spring arm (4) detachably in the position latched with the plug.
Patent DE-69904020-T2 (DE)
Inventor: COLOMBO PAOLO
IPC: A61K47/40
Filed: 1999-02-02
Granted: 2004-03-04
Abstract: The invention concerns a pharmaceutical composition for nasal administration of thiocolchicoside, with immediate or sustained release.
Patent DE-69907327-T2 (DE)
Inventor: VIALLETEL HUGUES
IPC: G01N3/00
Filed: 1999-07-02
Granted: 2004-03-25
Abstract: The sample (20) is compressed inside a cylindrical mold (17) between two parallel plates (16,19). The axis of the mold X can be inclined relative to the axis perpendicular to the plates Y and the X axis rotated about the Y axis. The mold has an external cylindrical sleeve (40) with axis Y and an internal cylindrical sleeve (43) with axis X, both connected to the plates via bearings. The means of compressing the sample are mounted on the chassis (2) and designed to apply a constant load F on one of the plates along an axis Y perpendicular to the plates. There are also means of controlling the means of compression and turning, and means of measuring the heights of the sample between the plates and the shearing loads on the sample as a function of the number of rotations of the X axis. A container (7) is at the top of the chassis, which has constant rigidity over 360 degrees and openings (11) in its top (10) and bottom (12). The top opening can be closed with a cover (15) which is to be pressed on by the upper plate. The bottom opening allows through a movable element (22) of the means of compression. The means of applying a turning motion comprise an external cylindrical sleeve (40) with axis Y mounted to rotate in the container via bearings (41,42). A cylindrical internal sleeve (43) with axis X is mounted to rotate about an outer mold with axis X intended to receive the mold via bearings (44,45). There are means of driving the external sleeve in rotation and the internal sleeve is mounted inside the external sleeve to oscillate, pivoting about an axis Z perpendicular to X and Y in the plane of the upper plate. The means of inclining the axis X of the mold relative to the axis Y include a system for controlling the angle between the external sleeve and the internal sleeve, mounted in the plane perpendicular to Z. The lower part of the chassis contains a lower plate, an upper plate on which the container is fixed and a number of columns (6) parallel to the Y axis connecting the two plates together. The lower chassis plate supports the means of compression, which comprises a driven worm screw (26) and a cover (22) moving along the Y axis and pressing on the lower compression plate. The cover is guided by rollers (28) acting with the columns and passing through an opening in the upper chassis plate via a bearing (24). A low friction plate is placed between the top of the cover and the lower compression plate. The worm is driven by an electrical servomotor with reduction and a displacement coder. The angle control system includes a vernier and means of measuring the compression achieved.
Patent DE-69915208-T2 (DE)
Inventor: ASSUMEL-LURDIN LUDOVIC
IPC: F15B11/12
Filed: 1999-10-25
Granted: 2005-02-17
Abstract: The actuator comprises two work pistons (26,27) connected to a work rod (28) on which slide two small auxiliary pistons (37,38) which can move in an auxiliary chamber (35). This chamber being permanently supplied with compressed gas causes the return by the auxiliary pistons of the work pistons and rod from a completely out position (to the right) of the rod to a completely re-entered (to the left) of this rod.
Patent DE-69921763-T2 (DE)
Inventor: IMSDAHL JOHN A
IPC: F02C7/143
Filed: 1999-11-18
Granted: 2005-12-15
Abstract: The present disclosure relates to an evaporative cooler including first and second trays each having a longitudinal axis. Each tray includes a bottom wall and two side walls that project upward from the bottom wall and extend generally parallel to the longitudinal axis of each tray. Each tray also includes two end walls that project upward from the bottom wall and extend between the side walls. Each tray further includes spaced apart cooler media retaining members that are generally parallel to the longitudinal axis of each tray. The trays are positioned in an end-to-end relationship such that the longitudinal axes of the trays are generally aligned with one another, and one of the end walls of the first tray is positioned adjacent to one of the end walls of the second tray. The evaporative cooler also includes an elongated clip adapted to extend the between the adjacent end walls of the first and second trays for inhibiting water leakage between the adjacent walls. <IMAGE>
Patent DE-69933296-T2 (DE)
Inventor: MANIQUE FLEMMING
IPC: C07K14/62
Filed: 1999-06-30
Granted: 2007-05-03
Abstract: A method for producing seeding microcrystals for the production of human insulin, said microcrystals being free of non-human pancreatic insulin, the method comprising providing an unseeded suspension of human insulin, said suspension being free of non-human pancreatic insulin, and homogenising said insulin suspension under pressure to result in human insulin microcrystals suitable for use as seeding microcrystals for the production of zinc insulin products. The method of homogenisation under pressure may also be used for the production of seeding microcrystals for other peptides and proteins, in particular pharmaceutical peptides or proteins such as insulin, GLP-1, glucagon and growth hormones.
Patent DE-69935851-T2 (DE)
Inventor: BRODERSEN RAINER
IPC: G11B27/034
Filed: 1999-01-21
Granted: 2008-01-10
Abstract: A method for compiling an authored multimedia presentation to obtain a multimedia data access program, the method being characterised by the steps of: 
creating a skeleton command segment layout from a plurality of program code segments, wherein instructions associated with the program code segments are abstracted; 
embodying the skeleton command segment layout in a skeleton data structure; 
receiving connection information including authored source and destination designations for a plurality of performance information elements and performance information access elements, wherein the performance information elements include menus and the performance information access elements include menu buttons; and, 
merging the connection information into the abstracted instructions in corresponding abstracted command segments.
Patent DE-69938046-T2 (DE)
Inventor: MOLLENAUER KENNETH H
IPC: A61H31/00
Filed: 1999-05-17
Granted: 2009-01-15
Abstract: A modular CPR assist device comprises a belt (4) adapted to extend around the chest of the patient, a belt tensioning means operably connected to the belt (4) for repeatedly tightening and loosening the belt (4) around the chest of the patient (20), a motor (43) operably connected to the belt tensioning means and capable of operating the belt tensioning means repeatedly to cause the belt (4) to tighten and loosen, and a controller (10) for controlling operation of the motor (43), wherein said controller (10) is further programmed to operate the motor (43) and the belt tensioning means such that upon loosening of the belt, loosening is limited to prevent the belt from becoming completely slack between cycles of tightening of the belt.
Patent HU-E034666-T2 (HU)
Title: Agent for treating and/or preventing sleep disorder
Inventor: UESAKA NORIAKI
IPC: A61P25/20
Filed: 2006-08-02
Abstract: The present invention provides a therapeutic and/or preventive agent for a sleep disorder comprising, as an active ingredient, a thiazole derivative represented by the general formula (I),   
[wherein R 1  represents a five-membered aromatic heterocyclic group including at least one oxygen atom, or the like, R 2  represents halogen or the like, and R 3  represents -NR 10 R 11  (wherein R 10  and R 11  may be the same or different, and each represents a hydrogen atom or the like), or the like] or a pharmaceutically acceptable salt thereof.