Patent SG-11201808913W-A (SG)
Title: Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer
Inventor: GUIDUCCI CRISTIANA
IPC: A61P35/00
Filed: 2017-04-14
Abstract: II o Unvaccinated D-04-Alum-OVApep SC D61-04-Alum-OVApep IT D61-04-Alum IT ,S - 2000- E1500- - a - .) 1000- E 500- t; 400 300 200 100 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/181128 Al 19 October 2017 (19.10.2017) WIPO I PCT (51) International Patent Classification: A61K 39/00 (2006.01) A61K 47/36 (2006.01) A61K 39/39 (2006.01) A61K 31/711 (2006.01) A61K 47/02 (2006.01) A61P 35/00 (2006.01) A61K 47/10 (2017.01) (21) International Application Number: PCT/US2017/027788 (22) International Filing Date: 14 April 2017 (14.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/323,622 15 April 2016 (15.04.2016) US 62/439,438 27 December 2016 (27.12.2016) US (71) Applicant: DYNAVAX TECHNOLOGIES CORPORA- TION [US/US]; 2929 Seventh Street, Suite 100, Berkeley, CA 94710 (US). (72) Inventors: GUIDUCCI, Cristiana; 1048 Talbot Avenue, Albany, CA 94706 (US). NAIK, Edwina; 5308 Genoa Street, Oakland, CA 94608 (US). MILLEY, Robert, J.; 3061 Bridsall Avenue, Oakland, CA 94619 (US). CHIP- MAN, Stewart, D.; 11042 Forest Ln NE, Bainbridge Is- land, WA 98110 (US). (74) Agents: LEKUTIS, Christine et al.; Morrison & Foerster LLP, 425 Market Street, San Francisco, CA 94105-2482 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: INTRATUMORAL ADMINISTRATION OF PARTICLES CONTAINING A TOLL-LIKE RECEPTOR 9 AGONIST AND A TUMOR ANTIGEN FOR TREATING CANCER FIG. 11A ns *** (57) : The present disclosure relates to methods for treating cancer by intratumoral delivery of particles containing a Toll- like receptor 9 agonist (TLR9) and a tumor antigen, in which the TLR9 agonist is a polynucleotide or a chimeric compound thereof. The methods of the present disclosure involve injection of the particles into at least one tumor, and are effective for treating both in - jected and uninjected tumors of a mammalian subject. Additionally, the present disclosure provides immunogenic compositions con- taining the particles, as well as methods of manufacture thereof. 1111111111111101110111111111110101111101110111H0111011101111101111111111111111111 W O 20 17 / 18 1128 Al