Patent GB-958132-A (GB)
Title: Animal and plant therapeutic compositions
IPC: C07F15/06
Filed: 1961-01-25
Abstract: Pharmaceutical, veterinary and agricultural fungicidal and virocidal compositions comprise a carrier and a 1,10-phenanthroline or 2,21-bipyridine derivative selected from the following classes of compounds:-  Class 1. Substituted 1,10-phenanthroline and 2,21-bipyridine and their acid addition salts with inorganic and strong organic acids, the 1 : 10-phenanthroline compounds having from one to six substituents selected from alkyl, phenyl, tolyl and xylyl groups in the 2-, 3-, 4-, 5-, 6-, 7-, 8- and 9-positions and the 2,21-bipyridine compounds having substituents of the same kind in from one to four of the 4-, 5-, 6-, 41-, 51- and 61-positions, in the case of the 1,10-phenanthroline compounds substitution being in from one to six of the specified positions with alkyl groups or in one or two positions with the aromatic groups, such alkyl mono-and di-substituents totalling from two to fourteen carbon atoms and where di-substitution by alkyl groups involves the 3- and 4- or 7- and 8-positions, the alkyl groups may be joined to form, together with the nuclear carbon atoms to which they are attached, a 5-membered or 6-membered cycloalkane ring system, such alkyl tri-, tetra-, penta- and hexa-substituents totalling from 3 to 14, 4 to 14, 5 to 14 and 6 to 14 carbon atoms respectively and such phenyl, tolyl and xylyl mono- or di-substituents totalling from 6-16 carbon atoms, and, in the case of the 2,21-bipyridine compounds substituted by alkyl groups in from one to four positions or in one or two of the 5- and 51-positions with the aryl groups, the alkyl substituents total from 4 to 10 carbon atoms and the aryl substituents total from 6 to 16 carbon atoms.  Class 2. Mono-N-alkylated substituted 1 : 10-phenanthroline and 2,21-bipyridine compounds represented by the formula (BR) + X-wherein B represents a base identified under Class 1 above, R represents a C1-6 alkyl or benzyl radical and X represents the anion of an inorganic or organic acid and:  Class 3. Metal complexes of the formul  (MB3)Xn and (MB2)Xn wherein M represents a metal selected from Fe++, Zn++, Mn++, Co++, Co+++, Cu++, Ni++, Ru++, Os++, Pt++, Pd++, Rh+++ and Ir+++, B represents a ligand provided by a base identified under Class 1 above except that the substituents are limited to the 3-, 4-, 5-, 6-, 7- and 8-positions on the phenanthroline nucleous and to the 4-, 5-, 41- and 51-positions on the pyridine nucleus, X represents the anion of an organic or inorganic acid and n is an integer determined by the oxidation state of the metal.  Numerous specific examples of active compounds are disclosed. p  The compositions may be in conventional forms, e.g. solutions, creams, lotions, nose, eye or ear drops, pessaries, suppositories, tablets or lozenges for pharmaceutical use, aqueous suspensions and solutions, ointments and drenches for veterinary use and dispersable powders and solutions for agricultural use. Veterinary and pharmaceutical compositions may also comprise materials which assist or enhance the action of the active materials, e.g. penicillin and tissue-penetrating enzymes.  Specifications 956,241 and 956,848 are referred to.