baber/WOPTO huggingface dataset:
Patent EA-201991763-A1 (EA)
Title: Конъюгаты антитела к ccr7 и лекарственного средства
IPC: A61K47/68
Filed: 2018-02-01
Abstract: В данной заявке раскрыты антитела к CCR7, их антигенсвязывающие фрагменты и конъюгаты антитела и лекарственного средства на основе указанных антител или антигенсвязывающих фрагментов. Настоящее изобретение также относится к способам лечения или предупреждения рака с применением антител, антигенсвязывающих фрагментов и конъюгатов антитела и лекарственного средства. В данном документе также раскрыты способы получения антител, антигенсвязывающих фрагментов и конъюгатов антитела и лекарственного средства, а также способы применения антител и антигенсвязывающих фрагментов в качестве диагностических реагентов.
Patent EA-201992125-A1 (EA)
Title: Стабильная ветеринарная композиция для местного применения
IPC: A61K31/7048
Filed: 2018-03-16
Abstract: Настоящее изобретение относится к стабильной ветеринарной композиции для местного применения, содержащей a) селамектин, b) диметилсульфоксид (ДМСО) в количестве от 0,5 до 15% мас./об., c) органический растворитель и d) необязательно антиоксидант.
Patent EA-202091852-A1 (EA)
Title: Способ получения n-[3-[5-(2-аминопиримидин-4-ил)-2-трет-бутил-1,3-тиазол-4-ил]-2-фторфенил]-2,6-дифторбензосульфонамида метансульфоната и продукт, полученный указанным способом
IPC: C07D417/04
Filed: 2020-08-31
Abstract: Изобретение относится к способу получения N-[3-[5-(2-аминопиримидин-4-ил)-2-трет-бутил-1,3-тиазол-4-ил]-2-фторфенил]-2,6-дифторбензосульфонамида метансульфоната (дабрафениба мезилата), противоопухолевого средства из группы ингибиторов киназ, а также продукту, полученному указанным способом. Техническим результатом является уменьшение пожаро- и взрывоопасности в рабочей зоне получения дабрафениба мезилата, снижение токсичности способа и получаемого продукта, уменьшение вероятности образования сольватов, полиморфных превращений и аморфизации продукта при производстве дабрафениба мезилата. Способ получения дабрафениба мезилата из основания дабрафениба и метансульфоновой кислоты или её ангидрида заключается в том, что синтез проводят в водной среде с использованием в качестве сырья основания дабрафениба с размером частиц до 0,2 мм.
Patent EA-202091859-A1 (EA)
Title: Применение антител к sirpa v1 человека и способ получения антител к sirpa v1
IPC: C07K14/705
Filed: 2019-03-13
Abstract: Настоящее изобретение относится к области иммунотерапии. Согласно настоящему изобретению предложены антитела, подходящие для применения в терапии и диагностике, которые нацелены на SIRPa человека, при этом указанные антитела усиливают перекрестную презентацию антигенов T-клеткам. Согласно настоящему изобретению также предложены антитела к конкретным изоформам SIRPa, способные нарушать взаимодействие между указанными изоформами SIRPa и CD47 человека, для применения при лечении или предотвращении заболевания или для применения в диагностике, и способы получения и/или выбора антител к SIRPa человека, которые связываются с различными изоформами представителей SIRP человека с разной аффинностью.
Patent ES-2174720-A1 (ES)
Title: Two part hinges cradle with rear seat hinges includes central seat hinges with a simplified seat inclination controller
Inventor: JANE CABAGNERO RAMON
IPC: A47D13/02
Filed: 2000-08-04
Abstract: Carrycot.It is composed of two parts, a front and back part that are inter-joined and that include a seat located on said front part the joint has, between the indicated two parts, resources that limit its rotation. It is characterised in that the resources that limit the rotation of said joint are each placed on each side of the carrycot said resources include a single control that is activated from the rear area of the back part of the carrycot. Said single control is composed of a U-shaped grip that, along its rear end, it attached in a joint manner to the corresponding area of the back part of the carrycot using a connecting rod. The seat is joined along its rear edge to the rear section of the front part of the carrycot, and along its middle area, it is joined using strips to the front area of the back part of the carrycot.< IMAGE >The two part hinged cradle with rear seat hinges has an openwork seat (4) with rear hinges (5) in the front half (1) of the cradle. A U-shape handle (17) and lateral pins (9) control the hinging and thus the inclination of the seat hinged both at the rear and also in its central zone via ties (7).
Patent ES-2189640-A1 (ES)
Title: Resin film for farming or gardening film, has resin composition layer with specified stress cracking resistance, and consisting of low-density polyethylene resin and ethylene/4-12C alpha-olefin copolymer resin
Inventor: KOJIMA TOMOKI
IPC: A01G13/02
Filed: 2001-05-23
Abstract: A resin film has a resin composition layer (C) having an environmental stress cracking resistance of 1000 hours or longer, and consisting of (parts by weight): (A) a low-density polyethylene resin (100); and (B) an ethylene/4-12C alpha-olefin copolymer resin (30-150). (C) serves as at least one outermost layer. A resin film has a resin composition layer (C) having an environmental stress cracking resistance of 1000 hours or longer, and consisting of (parts by weight): (A) a low-density polyethylene resin (100); and (B) an ethylene/4-12C alpha-olefin copolymer resin (30-150). (C) serves as at least one outermost layer. (A) has a melt flow rate of 0.1-10 g/10 minutes and a density of 0.92-0.94 g/cm3> or less. (B) has a melt flow rate of 0.1-10 g/10 minutes and a density of 0.91-0.93 g/cm3>.
Patent ES-2186544-A1 (ES)
Title: Security bolt activated by a magnetic key.
Inventor: TALLARICO ANTONIO
IPC: F16B23/00
Filed: 2001-06-08
Abstract: Security bolt activated by a magnetic key. Security bolt and magnetic key to activate, loosen, or tighten said bolt that incorporates resources for automatically interlinking, through magnetic attraction, the body of the cavity of the head of the bolt formed by a part fixed to the link rod and to the mobile part by applying the key. The security head of the bolt limits a cavity that is completely closed, for a magnetic material body that can axially move in said cavity equipped with lateral locking resources that cooperate with the resources of said body, solicited against the bottom of the cavity by a spring with support in the upper base of the mobile part, with external blind holes for the stud of the key. The latter is incorporated in a tubular body a permanent magnet on its end, with a stud support for reaching the blind holes and simultaneous applying a magnetic force through the support to the base of the mobile part. This attracts the body of the cavity and blocks the parts of the head to apply activation torque on the bolt.
Patent ES-2189679-A1 (ES)
Title: Monitorscope: light-tight chamber with viewer for the display of visual stimuli
Inventor: BLANCA MENA MARIA JOSE
IPC: A61B3/02
Filed: 2001-11-29
Abstract: Monitorscope: light-tight chamber with viewer for the display of visual stimuli.It consists of a light-tight chamber or box (1) attached at the rear to a computer monitor (6) and at the front to a viewer (2) and that allows eye adjustment for viewing the stimulus or visual information presented on the monitor. The light-tight chamber is placed on a table (8) in front of which the experimental subject is placed and on top of which the computer monitor, keyboard, and mouse are also placed to allow running the computer program that controls the display of the visual information. The main use of the device is the experimentation in visual perception and attention since it allows eliminating peripheral vision and maintaining other variables constant, such as the light of the visual field, brightness, contrast, and size of the stimulus.
Patent ES-2192491-A1 (ES)
Title: Powder form herb based food ingredient consists of a pastille made from ground e.g. artichoke dandelion and pumpkin plant material
Inventor: CALVO PACIOS JESUS
IPC: A23L33/105
Filed: 2002-03-26
Abstract: The powder-form herb-based food ingredient comprises a mixture of the plants arthichoke, lepidio, discorea, villosa, dandelion, walnut, desmodium, plantain and pumpkin seeds. Grinding and forming of pastilles facilitates consumption.
Patent ES-2234377-A1 (ES)
Title: Protective device for protecting seat belt closure of vehicle, has housing equipped with frame that is attached with closure for activating button when door of vehicle is opened
Inventor: BASTUS TORRENS JOSE
IPC: B60R22/18
Filed: 2002-12-04
Abstract: The device has a housing (1) equipped with a frame that is attached with a closure (6) for activating a button (8) when a door of a vehicle is opened. A panel is attached with a seat belt (7).
Patent ES-2246633-A1 (ES)
Title: Brake device for motor-scooter, has brake modulator with integral actuator of antilock brake modulator unit and master cylinder, arranged on inner side of vehicle front case
Inventor: TANI KAZUHIKO
IPC: B62L3/08
Filed: 2003-03-28
Abstract: A brake modulator (40) arranged on inner side of a vehicle front case, comprises integral actuator (10) of antilock modulator unit and master cylinder (17) of linked movement modulator unit. The antilock brake modulator unit is arranged at the side of front wheel brake (2).
Patent ES-2249119-A1 (ES)
Title: Method of establishing a nuclear reactor core fuel assembly loading pattern
Inventor: CHAO YUNG-AN
IPC: G21C17/00
Filed: 2004-02-09
Abstract: All possible loading patterns for a nuclear reactor core are searched and optimized for compliance with design constraints. The fuel inventory is divided into a few batches according to coarse levels of reactivity. A recursive enumeration process identifies patterns meeting selected core position constraints, which can be user modified to adjust the search space size. For the batch loading patterns satisfying the constraints, the batches are divided into several smaller batches. A sensitivity matrix linearizing the relationship between fuel assembly position and the depletion model is processed through mixed integer linear programming with branching and bounding to identify an optimal daughter loading pattern. The process is repeated through several levels of batch refinement and selection of optimal daughter patterns, including a level where burnable absorbers are assigned to feed assemblies, until the individual fuel assembly level is reached. The multiple optimal patterns remaining provide a range of solutions.
Patent ES-2255425-A1 (ES)
Title: Use of cyclopropenylsphingosine derivatives as ceramidase modulators for diagnosis and treatment of Farber's disease and treating e.g. cancer and cardiovascular disease
Inventor: FABRIAS DOMINGO GEMMA
IPC: A61P3/00
Filed: 2004-10-15
Abstract: Use of cyclopropenylsphingosine derivatives (I) is claimed to prepare a composition that modulates activity of ceramidase (II). Independent claims are also included for: (1) a composition (C1) containing (I), and (2) use of (C1) for diagnosing Farber's disease which comprises: (a) incubating (I) with control cells (CC) and with cells (CT) from the subject being tested (b) extracting the cells to recover lipids and filtering through an ion exchange column (c) measuring the fluorescence from the fraction that elutes in acidic medium, by comparison with values obtained using various concentrations of 12-(4-nitrobenzo-2-oxa-1,3-diazolo)dodecanoic acid (X), and (d) determining the amount of (X) formed from a substrate as a result of ceramide activity and if the amount of (X) formed in CT is significantly less than that formed in CC, Farber's disease is diagnosed. ACTIVITY : Cytostatic Cardiant Vasotropic Antiarteriosclerotic Antiinflammatory Antiasthmatic Antiarthritic Antirheumatic. MECHANISM OF ACTION : Ceramidase modulator. In a test, (1S,2S)-N-[2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (Ia) was incubated with rat liver microsomes (containing neutral and alkaline ceramidase) in the presence of the substrate N-[12-(4-nitrobenzo-2-oxa-1,3-diazolo)dodecyl]sphingosine. After 40 minutes at 37 [deg]C, the mixture was treated with methanol, centrifuged and the amount of 12-(4-nitrobenzo-2-oxa-1,3-diazolo)dodecanoic acid (X) formed measured by high performance liquid chromatography, as described in Anal. Biochem., 274 (1999) 264. Absorbance (in units X 103>) was 1800 in the absence of (Ia), but only 1400, 700 and 300 in the presence of 250, 500 and 1000 MicroM (Ia), respectively.
Patent ES-2259930-A1 (ES)
Title: Bitumen modifying device
Inventor: DANNERT DIETER
IPC: C08L95/00
Filed: 2005-04-12
Abstract: A device for easily and efficiently modifying bitumens to give bitumens modified with rubber powder from used tyres and suitable for the production of asphalt aggregates. The device consists of a hopper for the rubber powder fed through a metering unit to a pre-mixer into which bitumen is also delivered from the facility's tanks. Mixing is completed in said pre-mixer once the mixture is highly uniform, although the rubber particle size is not substantially reduced, then the mixture is transferred into a further mixing unit provided with a mixing member such as a colloid mill or the like or a mixing pump to give a fully uniform mixture that is then transferred into a holding tank or directly to the aggregates plant.
Patent ES-2274692-A1 (ES)
Title: Electric power supply device for electromechanical lock used on door, has transmitter with primary and secondary coils for transmitting electric power from power transmitter arranged outside door to receiver
Inventor: ROMANA SURIS FRANCISCO
IPC: E05B47/00
Filed: 2005-05-13
Abstract: The device has power supply unit arranged outside a door, receiver provided to receive electric power, and transmitter for sending electric power from power supply unit to receiver. The transmitter has primary and secondary coils arranged with air gap in between them. When door is closed, the primary coil faces secondary coil and electric power is supplied to primary coil. The electric power is used to generate electromagnetic field in primary ferromagnetic core. The electromagnetic field is received by secondary ferromagnetic core and converted into electric power by secondary coil. A magnetic core is arranged in the air gap. The primary coil is arranged in a primary module located in a wall. The secondary coil is arranged in a secondary module located in a door.
Patent ES-2245615-A1 (ES)
Title: Flocked band comprises a polyolefin film substrate onto which fibres are attached using a resin layer
Inventor: TALAVERA BARCELO JOSE
Filed: 2005-08-03
Abstract: A flocked band for vehicle profiles, comprises a substrate (1) onto which fibres (2) are attached. The substrate is a polyolefin film, and the fibres are fixed to it using a resin layer of ethylene-propylene-diene rubber (EPDM). The substrate has a urethane biocomponent and a cross-linking component, which form a barrier to the gases that attack the resin layer. The fibers are of acrylic, polyester, polyamide, spunbound or rayon.
Patent ES-2284341-A1 (ES)
Title: Trans-communic acid obtaining method, involves isolation and purification of acid in form of sodium salt
Inventor: ALVAREZ-MANZANEDA ROLDAN ENRIQ
IPC: C07C63/66
Filed: 2005-08-19
Abstract: The method involves isolation and purification of labda-8(17),12,14-trien-19-oic acid, which is known as trans-communic acid. The acid is obtained in the form of sodium salt, from the aerial part of Cupressus sempervirens. An independent claim is also included for the derivatives from Cupressus sempervirens.
Patent ES-2283232-A1 (ES)
Title: Concrete pieces production involves adding recycled dry goods, where arid wet phase is arranged prior to phase of mixture of concrete components, which is arranged prior to phase of atmospheric storage
Inventor: COSTA GENIS GENIS
IPC: C04B20/02
Filed: 2007-03-14
Abstract: The process involves adding recycled dry goods. An arid wet phase is arranged prior to a phase of mixture of concrete components, which is arranged prior to a phase of atmospheric storage. The phase of atmospheric storage is controlled before the phase of mixture of concrete components.
Patent ES-2339519-A1 (ES)
Title: Coffee machine for preparation and distribution of e.g. cappuccino, has electronic control circuit detecting optimal working cycle to automatically recall and repeat cycle, by distributing coffee in desired quantity and quality
Inventor: DAL TIO NELLO
IPC: A47J31/10
Filed: 2007-08-03
Abstract: The machine has an electronic control circuit elaborating a diagram of coffee consumption and of heating temperature of each of mutually identical coffee preparation and distribution groups (26). The circuit stores the diagram and periodically and automatically recalls the diagram to successively distribute the coffee in identical conditions. The circuit detects an optimal working cycle for infusion of the coffee based on the requirements and for selection of parameters of the coffee, to automatically recall and repeat the cycle, by distributing the coffee in desired quantity and quality.
Patent ES-2335954-A1 (ES)
Title: Washing machine
Inventor: GRACIA BOBED ISMAEL
IPC: D06F37/20
Filed: 2007-09-04
Abstract: The invention relates to a washing machine comprising an outer tub (1) and a counterweight (3) fastened thereto by means of a screwed connection, said screwed connection having a screw element (9) with two bracing elements (13, 19) at the ends thereof, guided through an opening (17) of the counterweight (3), between which elements the counterweight (3) and a fastening section (29) of the outer tub (1) are braced. According to the invention, at least one of the bracing elements (13, 19) at the ends is configured as a spiked plate (13) having at least one spike-type projection (43) which is forced into the fastening section (29) in the direction of bracing when the counterweight (3) is fastened and non-rotatably secures the spiked plate (13).
Patent ES-2341307-A1 (ES)
Title: System for processing a lithography sample by laser beam interference
Inventor: OLAIZOLA IZQUIERDO SANTIAGO MIGUEL
IPC: G03F7/20
Filed: 2008-12-16
Abstract: The invention relates to a system for processing a lithography sample by means of laser beam interference, in which a number "2n" of mirrors are positioned on a spatial plane (3), on which mirrors "2n" laser beams (1) are incident, said spatial plane (3) being parallel to a plane (4) containing the sample to be processed and the interference point "P" of the laser beams (1). The aforementioned point "P" is on the bisectors of the pairs of laser beams (1), each pair of laser beams (1) being in a plane normal to the plane (4) of the sample which can be moved and rotated around three Cartesian axes.
Patent ES-2346126-A1 (ES)
Title: System for handling cones on a road
Inventor: ARNALDOS ENRIQUE NICOLAS
IPC: E01F9/70
Filed: 2009-03-06
Abstract: The system, which is installed on a vehicle (14), incorporates a robotic arm (10) with a gripping device for seizing and releasing cones (12), a detection system (13) for detecting cones (12), driving means for driving the arm (10) between a pick-up position for picking up the cone (12) and an unloading position for unloading the cone (12) in a storage area and means for positioning cones (12) at a regular distance on said road. The gripping device comprises an elongated member (11) projecting in a cantilevered manner from a side of the vehicle (14) provided to face said cones (12) when the vehicle (14) moves backwards. The elongated member (11) incorporates a fixed half-clamp (15) and a mobile half-clamp (16), which can be moved closer to/away from said fixed half-clamp (15) to seize and hold an upper end of the cone (12) therebetween.
Patent ES-2385080-A1 (ES)
Title: Lipid nanoparticles for treating ocular diseases
Inventor: RODRIGUEZ GASCON ALICIA
IPC: A61K9/51
Filed: 2010-12-21
Abstract: The present invention relates to the use of a lipid nanoparticle system, where the nanoparticles comprise a nucleic acid, a lipid component, a cationic surfactant, a non-ionic surfactant, a polysaccharide, and optionally a positively charged peptide for the treatment and prevention of eye diseases.
Patent ES-2435324-A1 (ES)
Title: Method for separating the surfactants present in the washing liquors of corn, and uses
Inventor: VECINO BELLO XANEL
IPC: A23L29/10
Filed: 2012-06-18
Abstract: The invention relates to a method for separating the surfactants present in the washing liquors of corn, based on extraction with organic solvents. Furthermore, once the biosurfactants have been extracted from the corn washing liquors, the nutritional capacity of said corn washing liquors is evaluated using lactic bacteria, making sure that the nutritional capacity is maintained.
Patent JO-P20220138-A1 (JO)
Title: Methods of treating corona virus
Inventor: BARNETTE KESTER GARY
Filed: 2021-04-05
Abstract: The present invention relates to methods of treating coronavirus infections using compounds having anti-tubulin or tubulin disruption activity.
Patent RS-20140713-A1 (RS)
Title: A procedure for the production of wholegrain spelt-wheat bread with a reduced sodium content
Inventor: ŠIMURINA OLIVERA
IPC: A21D13/04
Filed: 2014-12-29
Abstract: A procedure for the production of wholegrain bread from spelt-wheat with reduced sodium content for the value of 30%, compared to the standard spelt bread, consists of a modified procedure that includes spelt poliš (three-point fermented dough from integral spelt flour) in the amount of 25% with wholemeal spelt flour in the amount of 75%, which makes the basic matrix of 100%, 2% of yeast on the basic matrix, 1.2% of salt on the basic matrix, and 56% of water on the basic matrix. The parameters included in the production process of the salty wholemeal bread from spelt-wheat, include total time of homogenization of the dough for 13 minutes in the dough kneader, shaping the dough and baking the shaped dough at a temperature of 230 ± 3 ° C for 21 minutes. The present procedure does not diminish the overall sensory and nutritional quality of wholegrain bread of spelt-wheat with reduced sodium content and has a positive influence on the taste and aroma of the crumb, in relation to the standard spelt bread, estimated by the expert panel.
Patent SG-90154-A1 (SG)
Title: Connection apparatus for waterway pipe
Inventor: AHN JUNG KI
IPC: F16L25/00
Filed: 2000-08-03
Abstract: A connection apparatus for a waterway pipe (10) is disclosed, which includes a plurality of pipes (10) each having both ends which are connected in series, a coupler (20) having protruded both ends and a connection member (21) having a plurality of connection grooves (22) for surrounding the connection portions of the pipes (10), an engaging member (30) which passes through the connection groove (22), and a coupling member (40) having one end inserted into the connection groove (22) and the other end contacting with one side of the connection member (21), so that the coupling member (40) moves backwardly and forward by a rotation force of the engaging member (30), and the coupler (20) is tightened and loosened.  <IMAGE>
Patent SG-114789-A1 (SG)
Title: Method of making a composite microporous membrane
Inventor: KHUY V NGUYEN
IPC: B29L7/00
Filed: 2005-03-07
Abstract: A method of making a composite microporous membrane includes the steps of: coating a nonporous precursor film with a polymer composition, and then stretching the coated nonporous precursor. Stretching includes a first stretching conducted at a first temperature and a first stretching rate and a second stretching conducted at a second temperature and a second stretching rate. The first stretching rate and the second stretching rate are different.