baber/WOPTO huggingface dataset:
Patent AU-2019101134-A4 (AU)
Title: A toolkit for providing early diagnosis and individualized drug therapy for monogenetic hypertension through exomic re-sequencing
Inventor: WEI KUANGYI
IPC: G16B25/10
Filed: 2019-09-30
Granted: 2019-10-31
Abstract: Abstract A toolkit for providing early diagnosis and individualized drug therapy for monogenetic hypertension through exotic re-sequencing is disclosed in this application. Monogenic hypertension is a serious form of hypertension characterized by early-onset and an incremental risk of cardio-cerebrovascular disease and renal disease. Clinical diagnosis of monogenic hypertension is often challenged by incomplete or overlapping clinical manifestation and requirement of genetic evidence. Here, a detailed clinical diagnosis process for monogenic hypertension was designed on the basis of Whole Exome Sequencing (WES). The evaluation criterion panel used in this diagnosis was built by pathogenic 102 single-nucleotide polymorphisms (SNPs) that can lead to monogenetic hypertension, they are selected based on their clinical significance in National Centre for Biotechnology Information website (NCBI) and PharmGKB databases. 1. Patients' exome were produced via high-throughput sequencing and the quality of the sequencing was evaluated by FastQC. 2. Software such as Burrows-Wheeler Aligner (BWA) and Genome Analysis Toolkit (GATK) were used to detect the disease-associated SNPs. 3. The detected mutated sites can be annotated to produce a reliable report for the patient. By identifying and listing the protein change, the report can provide clinicians with valuable information for effective individualized therapeutic option. Moreover, the anti-monogenic hypertensive drugs that specifically restore the pathway disturbed by these SNP and their proven target mutation points were summarized as a guid for precise medication. It can be used together with the genetic screening penal to greatly facilitate the treatment of monogenic hypertension. Literature research on various monogenic Literature hypertensions Examination of conditions of monogenic OMIMNCBI hypertensions using data from OMIM Match information on Search for medical NCBI to identify the healing plan refers to genomic locations of different types of PharmGKB variants monogenic Liddle syndrome Record information Congenital adrenal hyperplasia and divide the whole Syndrome of apparent mineralocorticoid excess(AME) based on conditions Geller syndrome Gordon syndrome Familial hyperaldosteronism type I Familial hyperaldosteronism type II Make a summarized FamilialhyperaldosteronismtypeIII chart Familial hyperaldosteronism type IV Familial pheochromocytoma Hypertension and Brachydactyly Syndrome Pseudohypoaldosteronism type IIE; PHA2E Figure 1
Patent AU-2020102436-A4 (AU)
Title: A novel tunnel drainage structure based on the principle of groundwater pressure gradient trigger switch
Inventor: WEI LIANGWEN
IPC: E02D31/00
Filed: 2020-09-25
Granted: 2020-11-05
Abstract: The invention discloses a novel tunnel drainage structure based on the principle of 
groundwater pressure gradient trigger switch, which comprises an annular blind drainage pipe 
buried between the secondary lining and the primary support structure of the tunnel, a 
longitudinal drainage blind pipe, and a transverse drainage blind pipe; The underground water 
pressure gradient switch structure is arranged at the lower end of the annular drainage blind 
pipe, and the drainage ditch is arranged along the longitudinal direction of the tunnel. With this 
structure, in light of the amount of groundwater in the surrounding rock stratum of the tunnel, 
the groundwater is discharged accordingly. Therefore, the underground water storage is 
ensured in dry season; In rainy season, the excess water can be smoothly drained away. This 
can effectively reduce the pressure on the second lining of the tunnel, and ensure the safety of 
the tunnel structure.
-1/4
D etail 
drawing 
Fig.1I
Patent AU-2021100192-A4 (AU)
Title: Vacuum sealing machine
Inventor: HE DING
IPC: B65B31/00
Filed: 2021-01-13
Granted: 2021-04-08
Abstract: The present application relates to the technical field of packaging equipments, 
which provides a vacuum sealing machine, including an upper cover, a base with one 
end hinged to the upper cover, two ejection mechanisms with a telescopic function, a 
first sealing strip disposed on the upper cover, and a second sealing strip disposed on 
the base and corresponding to the first sealing strip. The first sealing strip is 
connected to the upper cover through one ejection mechanism and the second sealing 
strip is connected to the base through another ejection mechanism. Through actions of 
the two ejection mechanisms, the first sealing strip and the second sealing strip are 
retained to abut against each other when the upper cover is buckled with the base, 
thereby ensuring a sealing performance of the vacuum sealing machine and 
prolonging the service life of the vacuum sealing machine.
1/4 
100 
41 
11 10 
20 
42 
21 
FIG.1I
Patent AU-2021100411-A4 (AU)
Title: Method for regulating concentration of solution in cstr process using fuzzy controller
Inventor: PUGAZHENTHI P NEDUMAL
IPC: G05B13/04
Filed: 2021-01-22
Granted: 2021-04-22
Abstract: A METHOD FOR REGULATING THE CONCENTRATION OF SOLUTION IN 
CSTR PROCESS USING FUZZY CONTROLLER 
Aspects of the present disclosure relate to method (100) for regulating the concentration of 
5 the solution in CSTR process using the fuzzy controller. The instructed concentration (116) 
of the solution is compared with the measured concentration (118). The error (120) that is 
found is sent to the fuzzy logic detection for determining whether the concentration of the 
solution is in steady-state or transient state, then the algorithm is initiated (108) according to 
the state. The variable parameters are provided (110) for the calculation of the calculated 
10 variable parameter.  
120 
102. 104 
D* *t GCECSTR 
116 h 
118 
FIG. 3 Block-diagram of a method for regulating the concentration of solution in CSTR 
process using fuzzy controller.  
15 
- 13 -
Application no.: Total no. of sheets: 4 
Page 4 of 4 
Servo response of CSTR for various controllers 
0.115 
Fuzzy P1 
ANFIS 
0.11 ------------ -------------------------------------------------- ----- egi ------ Setpoit 
- KtP D 
S- Fuzzy PD+1 
0.105 ------------ ---------------- -------------------------------- ---- ------------------------
0.1 ------------ ----------------- ------------------------------- ---- ------------------------
0.095 ------------ ------------------ ------------------------------- ---- -------------------------
o 0.1 
500 1000 1500 2000 
Time 
FIG. 4 Servo response of CSTR for various controllers 
Regulatory response of CSTR for various cotrollers 
0.14 
-Fuzzy P1 
Fuzzy PD+1 
0.13 ------------------------------------- ------------------------------------ Setpoit 
ANIS 
0.125 ------------------------------- ----- -------------------------------------- 4_PID 
2 0.12------------------ -------------------------------
o 1 1 'E0.115 ------------------------------- I----- - ---------------------- -------------------------------
0 0.11 ------------ ----------------- ----- ------ ------------- -------- ------------------
0.105 ----------- - ------------ ----------------------- --------------
0.1 ----------- ---------------------------------------------------------------
0.095-_________ 0.09 ---------- ------------------------ ----------------------------
0.00 
500 1000 1500 2000 
Time 
FIG. 5 Regulatory response of CSTR for various controllers 
4
Patent AU-2021101446-A4 (AU)
Title: A method for synthesizing carboxylate decorated metal organic frameworks using solvothermal conditions
Inventor: SHAHID M
IPC: C07F15/04
Filed: 2021-03-21
Granted: 2021-05-13
Abstract: The present disclosure relates to a method for synthesizing metal organic frameworks 
using solvothermal conditions. The three MOFs, Cu-MOF-2COOH, Ni-MOF-COOH and 
Cd-MOF are synthesized employing 1,3,5-benzenetricarboxylic acid (H3-BTC) as main 
ligand and 4,4'-dipyridyl (bipy) as spacer. The MOFs have been characterized using various 
spectral techniques and single crystal X-Ray studies. The topological analysis using TOPOS 
Pro reveals the MOFs possess varying topologies i.e., hcb, hxl, sql and 2C1. Cu-MOF
2COOH, Ni-MOF-COOH contain two and three uncoordinated carboxylic acid groups, 
respectively and in Cd-MOF, all the three -COOH are utilized in bonding. The dye 
adsorption property of MOFs with free carboxylate group(s) is checked and we found that 
both the MOFs are unable to adsorb any of the dye significantly. The free carboxylate 
group(s) in MOF inspire us elaborate its metal capturing property. In different solvents we 
have checked the metal capturing property of Cu-MOF-2COOH and Ni-MOF-COOH with 
different metal salts.  
32
CN (D 
o '4 
mm 
a)O 
c~ - L -4 n 
> u~) 0 L - _ a 
ua >~ w a)cu 
oa) w mJ a) -~ - - a c _ wc 
ED~ c- X~ WUa 
.2 c cu u .u xa) 
a) 0 a).aj 
a) >. a) CLn)C ' 
L00 u r, - f a) o 
cu~ a) CU Xaa) aai 
-a CU m ) m c C 
"E "a~a N- cWua -0 ) 
-2 W cu w0 aa) 
a) 00 ~ 0 0000 0~~~~ E nE_ 
-3- 0 -0 E 
E )a) cu _ja )a 
0~> -*a)0-) 
Eo a rc-E E E' 
o LiL 0~ 2- Li0 
0 0 o o~ o LDA20L.  = m " ") bf cl 
o 06 
a) A -5 a) 0C 
Ln a)a0a) 0 0 L ) 2 
CU
Patent AU-2021106753-A4 (AU)
Title: Hitch step
Inventor: NARDELLA PAUL
IPC: B60D1/06
Filed: 2021-08-24
Granted: 2021-11-18
Abstract: Disclosed is an accessory for a trailer hitch. The accessory is a mountable hitch step 
comprising a platform and a mount area, wherein the platform is adjacent to, and located 
off-set from, the mount area, and wherein the mount area is adapted to be selectively 
securable to a hitch ball mount.
1/4 
C4 CM ~ 
0o Q 
CNN 
0m 
C~C*D 
CC*I 
CJ.  
o 
c~cm
Patent WO-2014059974-A4 (WO)
Title: Multifunktions-mikroelektronikbauteil und herstellungsverfahren dafür
Inventor: HORNIG WOLFGANG
IPC: H01L23/38
Filed: 2013-10-16
Abstract: Die Erfindung betrifft ein Multifunktions-Mikroelektronikbauteil sowie ein Verfahren zum Herstellen eines solchen Multifunktions-Mikroelektronikbauteils, wobei das Verfahren folgende Schritte aufweist: Bereitstellen eines Substrats mit einer Vorderseite und einer Rückseite, Ausbilden eines oder mehrerer Bestandteile eines Mikroelektronikbauelements an der Vorderseite des Substrats, und Ausbilden eines oder mehrerer Bestandteile eines Peltierelements an der Rückseite des Substrats.
Patent WO-2013063480-A4 (WO)
Title: Procédé et système pour navigation de flotte, affectation et acheminement à véhicules multiples et destinations multiples
Inventor: HEED THOMAS PAUL
IPC: H04W4/021
Filed: 2012-10-26
Abstract: L'invention porte sur un système et sur un procédé pour l'affectation et l'acheminement de véhicules multiples vers de multiples destinations, avec ou sans contraintes, lesquels contiennent un noyau logiciel, qui utilise des régions géographiques délimitées (« BGR ») et des paires de nœuds pour optimiser explicitement, en deux dimensions, pour des variables désirées dépendant de l'utilisateur, par l'analyse d'une variance due à des variables standards et indépendantes définies par l'utilisateur. L'invention stocke des données de paire de nœuds, et peut utiliser une fonction d'erreur, une rétroaction et une analyse de variance/analyse de variance à variables multiples pour créer une solution d'affectation et de navigation étroitement convergente.
Patent WO-2014164898-A4 (WO)
Title: Source de lumière diffuse et système de dispositif d'éblouissement visuel composé de cette dernière
Inventor: MAIER NATHAN CHRISTOPHER
IPC: G02B17/00
Filed: 2014-03-11
Abstract: La présente invention se rapporte à une source de lumière diffuse destinée à être utilisée dans un éclairage à faible consommation d'énergie ainsi qu'à des systèmes de désorientation ou de perturbation visuelle, ladite source de lumière diffuse étant configurée avec un diffuseur à un seul tore solide (15) ou à deux cylindres rotatifs (35a, 35b) composé d'un matériau réfractant transparent dans lequel est couplée la lumière (13, 33) provenant d'un laser ou d'une source de faisceau lumineux de diode électroluminescente (DEL) (11, 31). La lumière (19, 39) se propage radialement vers l'extérieur dans toutes les directions depuis le diffuseur.
Patent WO-2016141174-A4 (WO)
Inventor: MENDEZ MAX PIERRE
IPC: A61B17/00
Filed: 2016-03-03
Abstract: A vessel occluding assembly includes first and second joined vessel aperture occluders each having a vessel aperture outer contact surface that, when one of the occluders is installed in a vessel aperture, hemostasis of a respective vessels is achieved, and a flexible tether connecting at the first and second occluders together such that, when the two occluders are implanted in a respectively vessel orifice, the occluders and the tether achieve sequential hemostasis of the plurality of vessels independent of relative tensions between the vessels.
Patent CH-692282-A5 (CH)
Title: Hot wire cutter especially useful for shaping polystyrene foam insulation on-site in the building trade
Inventor: VOEGELE RICHARD
IPC: B26F3/12
Filed: 1997-03-11
Abstract: A novel device for shaping, e.g. polystyrene foam, is based on a cutter (1) heated by a low voltage supply. A series switch is included. The switch comprises only two components, the cutter itself (1) as an active contact, and a passive, permanently-connected contact (2). These are brought together by pressure against the material being cut. The cutter passes through an opening in the passive contact, only touching it when the cutter is deflected, to make contact. Preferably, the cutter is a spring-tensioned heater wire in iron, copper or constan tan.
Patent CH-622299-A5 (CH)
Title: Holding device for practical utensils, such as sewing-thread bobbins
Inventor: WINKLER MORITZ
IPC: D05B91/14
Filed: 1978-01-20
Abstract: The holding device has, on a vertical stand (1), horizontal crossmembers (2) which decrease in size in steps from the bottom upwards at different distances and which are designed as rings (2'). The rings (2') are individually fastened rotatably to the stand (1) and possess vertical receiving members (3) which serve as pegs for slipping on tube-shaped practical utensils, such as sewing-thread bobbins, or as upwardly open tubes for inserting bar-shaped practical utensils. The holding device is characterised by an uncomplicated arrangement and an easy selection of the practical utensils. <IMAGE>
Patent CH-687112-A5 (CH)
Inventor: GREMION FRANCOIS
IPC: H01L21/368
Filed: 1993-06-08
Abstract: PCT No. PCT/IB94/00147 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Jun. 7, 1994 PCT Pub. No. WO94/29904 PCT Pub. Date Dec. 22, 1994.A method of making the compound CuInSe2 (CIS) by depositing a precursor of the compound at least partly electrolytically on a substrate and forming CuInSe2 by thermal reaction.
Patent CH-686778-A5 (CH)
Inventor: LORETTI MAURICE
IPC: A61J1/00
Filed: 1987-05-29
Abstract: The container (1) is intended for the separate storage of active compositions, especially of liquids or solutions, and for their subsequent mixing just before use. It comprises at least three compartments (3, 4, 5) separated from one another by leakproof seams (6) of the material of the envelope (2), sealable inlet passages (7, 8), sealed transfer passages (10, 11) and a sealable outlet passage (9). The envelope is made of a polymerized and homogeneous flexible material which is chemically inert to each of said compositions and to their mixtures.
Patent CH-690029-A5 (CH)
Title: Fusible substrate coating, especially for producing liquid- and gas-tight brazed joints in the watch and jewelry industries, comprises layers of different elements and-or alloys which form an eutectic melt
Inventor: SCHINDLER KURT
IPC: B32B15/01
Filed: 1995-10-11
Abstract: A fusible substrate coating (9), comprising layers (2,3) of different elements and/or alloys which form an eutectic melt, is new. Independent claims are also included for the following: (i) production of the above coating (9) on a substrate (1) by electro deposition of at least one of the layers (2, 3), by successive electro deposition of the layers (2, 3) from a common mixed electroplating bath or by PVD of at least one of the layers (2, 3); and (ii) a metal soldering or brazing process using the above coating (9).
Patent CH-657706-A5 (CH)
Inventor: LAVANCHY GERARD ANDRE
IPC: G01R31/02
Filed: 1984-06-18
Abstract: 1. Apparatus for measuring the electrical resistance of an isolated or non-isolated conductor, comprising a casing containing means of measurement this resistance, a curved support to support a section of said conductor, means of pinching-off to pinch off the ends of this section and to link them electrically to the means of measurement, characterized in that the curved support comprises a groove (11) having a V-shaped cross-section, so as to position the isolated conductor on the support without stretching it, in that said means of pinching comprise two sets (15, 16) of pinching means situated respectively at each end of the section of conductor, in that each set comprises a pair of blades (28, 29, and 34, 35) arranged so as to perforate the insulating sleeve which may be present and to ensure the electrical connection of the section to said means of measurement and in that in addition each set comprises a first carriage (17) provided with an isolating bearing plate (18), mobile along a direction substantially perpendicular to the section of the conductor, and a second carriage (24) provided with an isolating bearing plate (25) whose position is adjustable in relation to this section.
Patent CH-562968-A5 (CH)
Title: Coupling device for walls and frame components - has anchor with conical end enclosed in expanding ring
IPC: E04B1/58
Filed: 1973-03-01
Abstract: The components to be joined are coupled by an anchor, having a component sliding in the lenghtwise direction with a taper bore, in which a mating taper-ended screw, at right angles and eccentric to the bore, fits. The sliding component (4) has a conical end piece (5), enclosed by an expanding ring (9). the ring can be of elastic material such as plastic, or in the form of a spring circlip. The invention allows the anchor to be fitted in a plain bore instead of a specially shaped slot. Axial sliding movement of the anchor sleeve to the left results in contact of the conical end part of the expanding ring.
Patent CH-656414-A5 (CH)
Title: Composite profile comprising metallically bonded metal tubes with interposed insulating material for frames of wall elements, doors and windows, and process for the production thereof
Inventor: BIERI HANSPETER
IPC: E06B3/267
Filed: 1982-06-07
Abstract: The two steel tubes (6) having a rectangular cross-section are connected to each other, with interposition of a layer of refractory insulating material (18), by means of bolts (7) which are welded to the mutually facing tube walls and consist of a steel which lends itself well to welding. On a rolling-in path (1), the two steel tubes (6) are moved, with a tool (8) located therebetween and fixedly clamping the bolts (7), in stages through the welding station (3) and are moved away from there again on a rolling-out path (2). At the welding station with bottom fixed electrode (5a) and top movable electrode (5b), fixed bonding in groups is carried out cyclically by resistance welding as the tubes are advanced in stages. The bolts (7), the length of which is initially somewhat too long, are thereby shortened to the desired dimension of the tube spacing. After removing the tool (8), the interspace between the tubes is filled with insulating material. The composite profile is particularly suitable for producing fireproof door and window frames. <IMAGE>
Patent CH-677949-A5 (CH)
Title: Method of chimney construction - has inner wall of fire clay surrounded with layer of mineral wool
Inventor: ETTER ARMIN
IPC: E04F17/02
Filed: 1988-12-08
Abstract: The chimney is constructed with an inner wall (1) of fire clay surrounded by a layer (3) of thermal insulation.  This thermal insulation consists of mineral wool and is formed in two half shells (6,6'). These half shells are supported by an inner covering (4) of perforated steel sheet or expanded metal.  This covering is enclosed in an outer covering (2) of sheet steel.  This outer covering has a square cross-section with air ducts (5) formed in each corner.  This construction of chimney prevents the diffusion through the chimney wall of the water produced from the condensation of water in the flue gases.
Patent CH-661535-A5 (CH)
Title: Opening roller for an open-end spinning apparatus
Inventor: STAUFFER JOERG
IPC: D01H4/32
Filed: 1983-11-18
Abstract: The opening roller has a circular-cylindrical ring (7) which is provided with needles (8) on its circumference and which is closed off on one side by a cover (6) fastened with a press or shrink fit and having a plane and completely smooth outer face (6b). This cover possesses, on the inside, a coaxial bore (6a), in which the shaft (1) is firmly held in that the bore diameter, at room temperature, is smaller than, but, at a temperature at least 70 DEG , preferably approximately 100 DEG  higher, is larger than the diameter of the shaft (1), so that, after a corresponding heating of the cover, the shaft (1) can be drawn out of the bore (6a) without difficulty, whereas the cover is seated firmly on the shaft under normal conditions. As a result of this type of fastening, the two end faces of the components carrying the needle ring (7) can be made completely plane, that is to say free of elevations and depressions. <IMAGE>
Patent CH-661593-A5 (CH)
Title: Device for rotor balancing
Inventor: DON EDUARD ABRAMOVICH
IPC: G01M1/36
Filed: 1983-12-30
Abstract: The invention relates to motor building. The device for rotor balancing contains chambers (1) for stocking balancing masses (2) which are connected by means of lines (3) to a feeding mechanism (5) for balancing masses (2). In addition, the device contains an apparatus (20) for distributing balancing masses (2) between the lines (3), which is mounted on the rotor in such a way that the possibility of the working medium penetrating into the interiors of the lines (3) and the chambers (1) is excluded. The device can be used in motors which are operated using heavily polluted or dusty media. <IMAGE>
Patent CH-650302-A5 (CH)
Title: Set of structural elements for erecting wall and/or floor structures, in particular in exhibition construction
Inventor: GASSLER KURT
IPC: E04B2/74
Filed: 1980-11-25
Abstract: A support profile (10) has axially or vertically running webs (11) which are approximately T-shaped in cross-section and form, between them, corresponding, groove-shaped receiving locations (12). Load-bearing members (13, 14) for wall and/or floor parts are releasably fastened on the support profile (10) in each case by means of a tension lock (15) which is received in a load-bearing-member chamber, preferably in the interior of the hollow load-bearing member (13, 14). The tension lock (15) contains in each case three plate-shaped retaining elements (16, 17, 18) which engage radially into three neighbouring groove-shaped receiving locations (12) between four neighbouring webs (11) of the support profile (10). The three retaining elements (16, 17, 18) can be braced, by a tightening screw (24) arranged in the transverse direction with respect to said elements, against one another and against the webs (11) of the support profile (10). By tightening the tightening screw (24), the two outer retaining elements (16, 17) are simultaneously tilted, in the manner of a set of scales, about edges (67) provided on the central retaining element (18), with the result that their rear ends are braced against the inner wall (71) of the load-bearing-member chamber receiving the tension lock (15). A secure fastening of the load-bearing members (13, 14) on the support profile (10) is thus made possible at each point along the same using simple means. <IMAGE>