Patent NZ-331801-A (NZ)
Title: Therapeutic agent for diabetes
Inventor: SHINKAI HISASHI
IPC: C07C69/738
Filed: 1997-02-17
Abstract: Use of a compound of the formula [I] in the manufacture of a medicament for treating diabetes, wherein: X is -CR4R5-, -NR6- or -O-; R4 and R5 are the same or different and each is a hydrogen atom, an optionally substituted alkyl, alkenyl, aryl, acyl, carboxy, alkoxycarbonyl; R6 is a hydrogen atom or an amino-protecting group; R1 is an optionally substituted alky, alkenyl, aryl, heterocyclic group, cycloalkyl, cycloalkenyl, adamantyl, indanyl, fluorenyl or a group of the formula (a); R2 is a hydrogen atom, optionally substituted alkyl, alkenyl, an optionally substituted aryl, acyl, carboxy, alkoxycarbonyl;  R2 is a hydrogen atom; R3 is an optionally substituted alkyl, alkoxy, hydroxy, aryl, cycloalkyl atoms or an amino; R2 and R7 combine to form a group of the formula -CH2- or -(CH2)2-; R2 and R5 combine to form a bond, or a group of the formula -CH2-, -(CH2)2-, -(CH2)3- or -(CH2)4- ; R2, R2', R4 and R5 combine to form a group of the formula =CH-CH=CH-CH=; R3 and R5 combine to form a group of the formula -(CH2)3-, -(CH2)4-, -C(=O)-O-CH2-, -C(=O)-(CH2)2- or -C(=O)-(CH2)3-; R2' and R3 combine to form a group of the formula -CHR8-O-, -CHR8-CHR9-O-, -CHR8-CHR9-, -CHR8-NH-, -O-CHR8-, -O-CHR8-CHR9- or -NH-CHR8-; R8 and R9 are the same or different and each is a hydrogen atom, an optionally substituted alkyl, alkoxy, alkoxycarbonyl or acyloxy; A prodrug, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. A compound of the formula (II) wherein: When R3'' is a hydroxy, R4'' is a hydrogen atom, acyl, carboxy or alkoxycarbonyl, and R1'' is a cycloalkyl which is mono-substituted by a substituent selected from the group consisting of alkyl, hydroxy, alkoxy, aryl, acyl, amino, carboxy and alkoxycarbonyl; When R3'' is an alkyl or alkoxy, R4'' is acyl, carboxy or alkoxycarbonyl and R1'' is a cycloalkyl which is mono-substituted by a substituent selected from the group consisting of alkyl, hydroxy, alkoxy, aryl, acyl, amino, carboxy and alkoxycarbonyl; A prodrug, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. A compound of the formula (III) wherein: When R3''' is a hydroxy, R4''' is a hydrogen atom, alkyl, acyl,  carboxy or alkoxycarbonyl, R5''' is a hydrogen atom, alkyl, acyl, carboxy or  alkoxycarbonyl, and R101 is alkyl which is substituted by hydroxy; When R3''' is an alkyl, R4''' is a hydrogen atom, alkyl, acyl, carbon or alkoxycarbonyl, R5''' is a hydrogen atom, alkyl, acyl,  carboxy or alkoxycarbonyl, and R101 is an alkyl which is substituted by hydroxy or an aryl substituted by a substituent carboxy, alkoxycarbonyl, hydroxy, alkyl, alkoxy, aryl, acyl and amino; and when R3''' is alkoxy, R4''' is a hydrogen atom, alkyl, acyl, carboxy or alkoxycarbonyl, R5''' is a hydrogen atom, alkyl, acyl, carboxy or alkoxycarbonyl atoms, and R101 is alkyl which is substituted by hydroxy, or an aryl substituted by carboxy, alkoxycarbonyl, hydroxy, aryl, acyl or amino; a prodrug, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. A compound of the formula (IV) wherein: A and B are the same or different and each is C, NH or O; When R2''' is a hydrogen atom, R101' is alkyl substituted by hydroxy or an optionally substituted aryl; and When R2''' is an alkyl having 1 to 4 carbon atoms, R101' is hydrogen atom, alkyl substituted by hydroxy or an optionally substituted aryl; A prodrug, a pharmaceutically acceptable salt, a hydrate or a solvate thereof.