Patent SG-11201808729W-A (SG)
Title: Bet protein degraders
Inventor: WANG SHAOMENG
IPC: C07D487/04
Filed: 2017-04-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111111011101111101011111111101111011111 International Bureau ... .... ..Yjd (10) International Publication Number ..... ...,/ (43) International Publication Date WO 2017/180417 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: NAPOLI, James, J.; Marshall, Gerstein & Borun C07D 487/04 (2006.01) A61P 35/00 (2006.01) LLP, 233 S. Wacker Drive, 6300 Willis Tower, Chicago, A61K 31/4745 (2006.01) IL 60606-6357 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/026278 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 6 April 2017 (06.04.2017) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/321,499 12 April 2016 (12.04.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/393,888 13 September 2016 (13.09.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office of Technology Transfer, (84) Designated States (unless otherwise indicated, for every 1600 Huron Parkway, 2nd Floor, Ann Arbor, MI 48109- kind of regional protection available): ARIPO (BW, GH, 2590 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, _ (72) Inventors: WANG, Shaomeng; 3336 Stirling Ct., Superi- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, or Township, MI 49198 (US). ZHOU, Bing; 555 Zu DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — _ Chong Zhi Road, Shanghai Institute Of Materia Medica, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Room 3508, Shanghai 20123 (CN). XU, Fuming; 3111 In- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ternationa Dr., Apt. 2203A, Ypsilanti, MI 48197 (US). GW, KM, ML, MR, NE, SN, TD, TG). HU, Jiantao; 3005 Whisperwood Dr., Apartmetn 280, Ann Arbor, MI 48105 (US). BAI, Longchuan; 1530 Wood- Published: creek Blvd., Ann Arbor, MI 48104 (US). YANG, Chao- — with international search report (Art. 21(3)) - - . Yie; 4826 Hillway Court, Ann Arbor, MI 48105 (US). = = = = = = = = = Title: BET PROTEIN DEGRADERS — (54) = 0 R1 ,-1 . 4 1 4101 IN N- Q 1 11 0 0 0 0 N Q2 -1 ,.. x .L... y -B H I 1-1 IN 1-1 (57) : The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hy - 0 drates, and solvates thereof, wherein B, R I , R 5 , Q I , Q\", L, X, Y, and Z are as defined as set forth in the specification. The present dis - \" closure also provids compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodo - 0 mains such as cancer.