baber/WOPTO huggingface dataset:
Patent IT-PT960001-A1 (IT)
Title: Metodo per la crittografazione di segnali video telvisivi con effetto  di rimbalzo continuativo dell'immagine dalla base al vertice dello
Inventor: TOMMEI DANIELE
IPC: H04K/
Filed: 1996-01-29
Abstract: METODO PER LA CRITTOGRAFAZIONE DI SEGNALI VIDEO TELEVISIVI CARATTERIZZATO DAL FATTO CHE ESSO CONSENTE DI OPERARE CON CONTINUITA' LA INVERSIONE DI POLARITA' E LO SCAMBIO DI POSIZIONE DI UN NUMERO PRE STABILITO DI RIGHE O LINEE ORIZZONTALI IN MODO DA OTTENERE, IN FASE DI RICEZIONE DELL'IMMAGINE VEICOLATA DAI DETTI SEGNALI, UN EFFETTO DI RIMBALZO CONTINUATIVO DELL'IMMAGINE DALLA BASE AL VERTICE DELLO SCHERMO DELL'APPARATO RICEVENTE, INSERENDO UNO O PIU' SEGNALI DI CONTROLLO IN LINEE PRESTABILITE DELL'INTERQUADRO.
Patent IT-TO930142-A1 (IT)
Title: Dispositivo di comando per sistemi di guida a barra di comando
Inventor: MARUELLI STEFANO
IPC: A63H30/04
Filed: 1993-03-01
Abstract: Dispositivo (1) di comando per sistemi di guida a barra di comando del tipo comprendente almeno un braccio snodato (2) con sistema di aggancio (3), un sistema di movimentazione su due assi in contemporanea (4), un corpo portante (5), vani di alloggiamento dei servomotori (6), degli apparati e dell'apparato ricevente (8), dell'apparato o degli apparati di alimentazione (10), un sistema di collegamento alla pedaliera (9), uno o più bracci di comando della o delle manette del carburante (9). fig.1 e fig.2
Patent IT-TO950568-A1 (IT)
Title: Dispositivo di controllo per una lampada a scarica di gas
Inventor: NEPOTE ANDREA
IPC: H05B41/288
Filed: 1995-07-06
Abstract: Il dispositivo comprende una sorgente di tensione continua (B), un convertitore dc/dc (1) atto a fornire una tensione più elevata di quella della sorgente (B), un invertitore (2) a cui è collegata la lampada (L), e un'unità di controllo (ECU) che pilota il convertitore (1) e/o l'invertitore (2) in modo tale da trasferire alla lampada (L) una potenza elevata all'accensione, ed una potenza ridotta nel successivo funzionamento della lampada a regime. Dispositivi rilevatori (R; 3, 4) forniscono all'unità (ECU) segnali indicativi dell'impedenza della lampada (L).All'unità (ECU) sono associati dispositivi di memoria (M) di tipo non volatile in cui sono memorizzati dati indicativi del valori dell'impedenza (Zc) della lampada al variare del tempo (torr) trascorso dal suo spegnimento. L'unità (ECU) è predisposta per acquisire, ad ogni accensione, l'impedenza (ZL) presentata dalla lampada (L), confrontare tale impedenza (ZL) con i valori immagazzinati in dette memorie (M), e determinare in base a tale confronto il tempo (torr) trascorso dal precedente spegnimento della lampada (L).(Figura 1).
Patent IT-VI960160-A1 (IT)
Inventor: CERATO MASSIMO
IPC: E04H15/58
Filed: 1996-10-15
Abstract: The frame for a marquee comprises, in its upper part, several slightly inclined tubes (2). These tubes converge at their upper end (2') to form the top of the marquee. Each tube is connected at its other end to a tubular upright (3) which is supported on the ground. The top ends of the tubes are folded down and located parallel to each other and fixed together by several bolts (4) which pass through them. The bolts are fixed one to the other in their middle to form a single crosspiece.
Patent NO-20100538-A1 (NO)
Title: Flytende understell
Inventor: LAUKELAND LARS
IPC: B63B75/00
Filed: 2010-04-15
Abstract: Et understell (8) av dypcaisson-typen med en lengdeakse (O) har et nedre parti (8c) i en vannmasse og et øvre parti (8a) for understøttelse av en plattform (2) over en vannflate (F). Understellet omfatter et utvidet parti (8b) i et område mellom det øvre partiet (8a) og det nedre partiet (8c), hvorved understellets egenperiode i hiv økes. Det utvidede partiet (8b) kan omfatte ett eller flere innvendige lagerkamre (18) og ett eller flere ballastkamre (16).
Patent NO-20110573-A1 (NO)
Title: Antirotasjonskile av kamtype for rorforbindelser
Inventor: PALLINI JR JOSEPH WILLIAM
IPC: E21B17/043
Filed: 2011-04-14
Abstract: En antirotasjonsnøkkel innsettes i en lomme formet på en ytre overflate av en hanngjenget kopling. Nøkkelen har et nedre innsideparti for kontakt med basen til lommen. En rekke av tenner på et nedre utsideparti av nøkkelen biter inn i en indre vegg til en hunngjenget kopling etter som nøkkelen er tvunget inn i lommen. En av kantene til nøkkelen er utformet slik at en linjetangent til den første sidekant hvor den krysser det nedre ytre sideparti vil krysse en linjetangent til et sentralt parti til det nedre indre sideparti ved en vinkel mindre enn 90 grader. Relativ bevegelse mellom de hann- og hunngjengede koplinger i en løsgjøringsretning bevirker at nøkkelen dreier seg omkring et inngrep av den første sidekant med den første sidevegg og biter dypere inn i den indre vegg til den hunngjengede kopling.
Patent NO-20110722-A1 (NO)
Title: Boreapparat og - fremgangsmate
Inventor: HUFTHAMMER HARALD
IPC: E21B21/08
Filed: 2011-05-16
Abstract: Oppfinnelsen tilveiebringer en apparatur og en fremgangsmåte for håndtering av borefluid under en subsea boreoperasjon. Fremgangsmåten omfatter å tilveiebringe et legeme til et område for en subsea brønn og ta i mot borefluid og medbrakte faste stoffer inn i kammeret fra et brønnhull på brønnområdet. Borefluid og medbrakte fluider blir prosessert ved brønnområdet for å bryte opp de medbrakte faste stoffene, og det prosesserte borefluidet og de medbrakte faste stoffene blir fraktet opp til overflaten ved å pumpe borefluidet og de medbrakte faste stoffene gjennom en returkanal.
Patent NO-20171996-A1 (NO)
Inventor: SMITH ROBERT E
IPC: F16K11/074
Filed: 2017-12-14
Abstract: A sliding metal seal valve comprises one or more non-circular (oblate) metal seals. Use of non- circular (oblate) sliding metal seals, permits the rotor of a rotary sliding metal seal valve to have a smaller diameter which permits a smaller overall valve size. Reduced rotor diameter also reduces the torque required to turn the rotor, permitting smaller actuator motors to be used. Axially sliding valves such as bar valves may also employ such non-circular sliding metal seals to permit a reduction in the width of such valve.
Patent PE-20000544-A1 (PE)
Title: Forma de dosificacion de nefazodona
Inventor: TIMMINS PETER
IPC: A61K9/20
Filed: 1999-06-04
Abstract: SE REFIERE A UNA FORMULACION FARMACEUTICA DE LIBERACION CONTROLADA/PROLONGADA DE NEFAZODONA Y QUE SE CARACTERIZA PORQUE LA LIBERACION DEL FARMACO SE DA DE LAS 4 A 16 HORAS, CON NIVELES TERAPEUTICOS PROLONGADOS HASTA POR 24 HORAS, CANTIDADES REDUCIDAS DE METABOLITOS DE NEFAZODONA TAL COMO m-CLOROFENILPIPERAZINA, NO ES INCOMPATIBLE CON EL ALIMENTO; TRATANDOSE DE UNA FORMA DE DOSIFICACION MODULADA POR EL pH, CON UNA VISCOSIDAD DE 3 cps A 100 cps; COMPRENDE DE 33% A 45.5% DE CLORHIDRATO DE NEFAZODONA, DE 16% A 33% DE UN POLIMERO DE GELIFICACION NO IONICO (HIDROXIPROPILMETILCELULOSA), DE 10% A 21% DE UN POLIMERO DE GELIFICACION IONICO (ALGINATO DE SODIO), DE 16% A 22% DE UN AGENTE HIDROFILICO INSOLUBLE (CELULOSA MICROCRISTALINA). LOS EXCIPIENTES DE LA FORMULACION PUEDEN SER COLORANTES, SILICE COLOIDAL, ESTEARATO DE MAGNESIO. LA NEFAZODONA ESTA INCRUSTADA EN UNA MATRIZ, FORMADA EN MICROPELLAS o FORMADA EN MICROPELLAS RECUBIERTAS. UNA COMPOSICION PREFERIDA CONTIENE DE 40%-45% DE CLORHIDRATO DE NEFAZODONA, DE 16% A 20% DE HIDROXIPROPILMETILCELULOSA, DE 19%-22% DE ALGINATO DE SODIO, DE 19%-22% DE CELULOSA MICROCRISTALINA, DE 1%-15% DE ESTEARATO DE MAGNESIO. LA NEFAZODONA ES UTIL COMO BLOQUEADOR DEL RECEPTOR 5HT DE SEROTONINA ACTUANDO COMO ANTIDEPRESOR
Patent PE-29998-A1 (PE)
Title: Procedimiento de preparacion de enantiomeros de o-demetiltramadol y a su aplicacion en analgesicos
Inventor: BUSCHMANN HELMUT
IPC: A61P25/04
Filed: 1996-12-18
Abstract: CARACTERIZADO PORQUE COMPRENDE: A) CONVERTIR EN BASE LA SAL RACEMICA DE TRAMADOL (CLORHIDRATO DE TRAMADOL); B) PRECIPITAR MEDIANTE EL ACIDO L(+)TARTARICO Y EN PRESENCIA DE UN ALCOHOL C1-C5, EL ENANTIOMERO (-) DEL TRAMADOL; C) DEJAR EN LIBERTAD LA BASE; D) CONVERTIR EL CORRESPONDIENTE ENANTIOMERO DE LA BASE DE TRAMADOL EN CLORHIDRATO DE TRAMADOL, A PARTIR DEL CUAL LUEGO SE DEJA EN LIBERTAD LA BASE; E) HACER REACCIONAR LA BASE CON HIDRURO DE DI-ISOBUTIL-ALUMINIO, EN PRESENCIA DE TOLUENO; EN EL PASO (B) DE LAS AGUAS MADRES DE PRECIPITACION CON EL ACIDO L(+)TARTARICO, SE PREPARA EL ENANTIOMERO (+), SIGUIENDO LOS PASOS (C), (D) Y (E). ESTE PROCEDIMIENTO PERMITE OBTENER ENANTIOMEROS PUROS DE O-DEMETILTRAMADOL, CON ALTO RENDIMIENTO, PARA SER USADO COMO ANALGESICO EN FORMA DE BASE Y/O SAL, COMO RACEMATO O ENANTIOMERO (+), COMO PRINCIPIO ACTIVO UNICO O EN COMBINACION CON TRAMADOL
Patent PL-122562-A1 (PL)
Inventor: KŁOSIŃSKI JANUSZ
IPC: B65D23/00
Filed: 2012-01-30
Abstract: Butelka z systemem zabezpieczającym przed fałszerstwem, przy czym elementem zabezpieczenia jest trwałe oznakowanie butelki charakteryzuje się tym, że na ściance poszczególnej butelki wykonany jest laserowo w sposób trwały, indywidualny ciąg znaków (3), będący numerem banderoli (2) zabezpieczającej daną butelkę, przy czym ten ciąg znaków jest wykonany co najmniej jednokrotnie oraz w sposób widoczny, w pobliżu papierowej banderoli (2), aby można było porównać obydwa oznaczenia. Oznakowanie może być wykonane na zewnętrznej albo na wewnętrznej powierzchni butelki. Rozwiązanie łączy w sobie różne filozofie zabezpieczeń przed fałszerstwem, a mianowicie stosuje trwałe oznakowanie samej butelki, wykorzystuje też ideę indywidualnego oznakowania poszczególnej butelki. Ponadto wzór użytkowy dodatkowo zwiększa zabezpieczenie systemu oznakowania banderolą.
Patent PL-240541-A1 (PL)
Title: Pecticide and process for manufacturing aryl esters of n-oxalyl-n-methylcarbamic acid
IPC: C07D307/86
Filed: 1983-02-11
Abstract: Aryl N-oxalyl-N-methyl-carbamates of the general formula    <IMAGE> (I)  in which X represents an alkoxy, alkenoxy, alkinoxy, aryloxy, alkylthio, alkenylthio, alkinylthio or arylthio radical, each of which may be optionally substituted or represents a radical of the general formula -N R3R4, wherein R3 and R4 are identical or different and represent a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl or aryl radical, each of which may be optionally substituted, or the radicals R3 and R4, together with the N atom to which they are bonded, form an optionally substituted heterocyclic ring, and R1 represents an aryl radical which is optionally substituted, are novel and find use as pesticides, especially for combating insects, acarids and nematodes.
Patent PL-291218-A1 (PL)
Title: Apparatus for making hamburgers
IPC: A23L13/00
Filed: 1991-07-24
Abstract: The duct (6) for meat is equipped with a valve (17) for cutting the delivery at intervals and with a plate (14) for regulating the passage of the meat (7). The reels of paper (9, 10) for wrapping the hamburger are equipped with respective overrunning brakes (26) and with sensors (25) which, when the paper is finished, touch the core (23) of the reel and stop the machine. One of these paper webs carries a series of marks (20) which, when they pass via the cell (21), give rise to the operation of the punching member (11). There is also a rod (40) which separates the end of the minced meat adjacent to the hamburger, and another rod (41) which, when it rises due to an obstruction, touches a microswitch and stops the machine. The remaining paper scrap is propelled by means of air (35) towards a bag (37). 
<IMAGE>
Patent PL-298517-A1 (PL)
Title: Absorbing object with flexible interior
Inventor: OSBORN THOMAS WARD III
IPC: A61F13/00
Filed: 1992-07-23
Abstract: A napkin comprises an absorbent core between a pervious topsheet and an impervious backsheet, with all parts extensible, and a fastener for securing the napkin to the garment, the fastener allowing at least parts of the napkin to extend. The napkin is pref. extensible both longitudinally and transversely and may require extending before applying to the garment, or may be extended by forces applied during use. Stretched length is pref. at least 25% greater than unstretched length. The napkin may be provided with a pull-out tab so that the user can lengthen the napkin.
Patent PL-302155-A1 (PL)
Title: Prefabricated structure for making leakproof, thermally insulated walls of enclosed spaces for holding liquids at very low temperature
Inventor: CHAUVIN JEAN-MICHEL
IPC: F17C3/02
Filed: 1993-05-19
Abstract: The present invention relates to a prefabricated structure making it possible to produce fluid-tight and heat-insulating walls for a heat-insulated containment chamber (vessel) such as a fluid-tight tank for storing and/or transporting a cryogenic (very low temperature) fluid. This structure (1) which comprises an internal fluid-tight and flexible barrier (2), an insulation system (4), and an external skin (3) forming a support for the structure (1) is characterised in that distribution panels (53) secured to the external skin (3) are fixed to the latter particularly by screws or the like (35) located facing holes (435) formed in an external insulating layer (43) at a distance from joints (63) between plates (43a) forming this layer, whilst a fluid-tight connection (80) is located hermetically in each of these holes (435) and joints (63). The invention applies to the production of structures forming fluid-tight tanks, for example for ships for transporting cryogenic liquids such as methane tankers. <IMAGE>
Patent PL-306295-A1 (PL)
Title: Method of carrying out underground construction work
Inventor: DERWAND HELMUT
IPC: E02D31/00
Filed: 1994-04-18
Abstract: According to a process for carrying out civil engineering works in the area of the sole (4) of an existing waste dump, passable shafts (1, 2) designed as mutually spaced, cased large hole borings are sunk down to the waste dump sole (4). At the level of the waste dump sole (4) the shafts (1, 2) are interconnected by a passable tunnel (5), forming a continuous working room. A sufficiently large working room is thus simply created above the waste dump sole (4) for carrying out sanitation works.
Patent PL-307190-A1 (PL)
Title: Novel derivatives of 4-amino piperidinyl-(1)-benzoyl guanidine, method of obtaining them and pharmaceutical preparation and method of preparing same
Inventor: GERICKE ROLF
IPC: C07D211/58
Filed: 1995-02-09
Abstract: 4-Amino-piperidino-benzoyl-guanidines of formula (I) and their salts are new: R1 and R2 = H, A, Ph, Alk-Ph, CO-A, CO-Ph, CO-Het or protecting gps., or R1 + R2 = 4-5C alkylene, which opt. has 1-2 CH2 gps. replaced by O, S, CO, NH, NA and/or NCH2Ph and is opt. fused to a benzene ring to form a dihydroindolyl, tetrahydroquinolyl, tetrahydroisoquinolyl or dihydrobenzimidazolyl gp.; R3 and R4 = H, A, Hal, XR5, CN, NO2, CF3, CH2CF3, S(O)nR7 or SO2NR5R6; R5 = H, A, CF3, CH2CF3, Ph, Alk-Ph, 5-7C cycloalkyl or (5-7C) cycloalkyl(1-4C)alkyl-; R6 = H or A; or R5 + R6 = 4-5C alkylene, opt. with a CH2 gp. replaced by O, S, NH, NA or NCH2Ph; R7 = A or Ph; X = O, S or NR6; A = 1-4C alkyl; Alk = 1-4C alkylene; Hal = F, Cl, Br or I; Ph = unsubstituted or mono-, di- or trisubstituted by A, OA, Hal, CF3, NH2, NHA or NA2 (sic); Het = satd. or unsatd. 5- or 6-membered heterocyclyl contg. 1-4 N, O and/or S atoms; n = 1 or 2.
Patent PL-309215-A1 (PL)
Title: Method of treating fabrics in order to make them non-flammable
Inventor: PING LEI XIAO
IPC: D06M15/431
Filed: 1995-06-21
Abstract: In the flame-retardant treatment of fabrics, there is provided a means for increased "loading" of phosphorus compounds (up to 25% moisture is retained after impregnation and drying of the fabric). This in turn enables a phosphonium compound "add-on" of 50% to 73% (relative to the weight of the fabric) and gives a correspondingly higher degree of flame-retardant properties.
Patent PL-312784-A1 (PL)
Title: Impregnable reservoir of active substance solution designed for ionophoretic hypodermic application of medicines and production technology of the aforementioned reservoir
Inventor: DHUIQUE-MAYER DANIEL
IPC: A61N1/30
Filed: 1994-08-03
Abstract: PCT No. PCT/FR94/00974 Sec. 371 Date Feb. 26, 1996 Sec. 102(e) Date Feb. 26, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/06496 PCT Pub. Date Mar. 9, 1995The reservoir loaded with a divided material which can be impregnated with the solution of active principle, comprises a) a support sheet (1) made of a cavitied material which is permeable to the solution and capable of contributing to the mechanical strength of the reservoir b) a layer (3) of particles of the impregnatable material and c) a substrative layer (2) interposed between one face of the support sheet (1) and the layer of particles (3) in order to hold the latter on the support sheet (1), this substrative layer (2) consisting of a substance which is miscible with the solution of active principle.
Patent PL-325868-A1 (PL)
Title: Injection moulding machine with a charging cylinder
Inventor: NORESSON NILS GUNNAR
IPC: B29C45/54
Filed: 1996-09-24
Abstract: A method in injection moulding wherein the plastic material is being screw plasticized and piston injected and wherein the plasticized plastic material is supplied to the piston injection cylinder (18) during the return of the injection piston (19). The plasticizing screw (12) is rotating continuously in a fixed axial position in the plasticizing cylinder (10) the pressurized plastic material being temporarily stored in a pressurized space (26) during the operating stroke of the injection piston in order to be supplied during the return of the injection piston from said space to the injection cylinder together with plasticized plastic material supplied directly from the plasticizing screw (12) to the injection cylinder. An injection moulding machine for working the method comprises a screw plasticizing cylinder (10) and a piston injection cylinder (18) connected to the outlet of the screw plasticizing cylinder via a non-return valve. A charging cylinder (26) having a pressurized piston (27) is connected directly to the outlet of the plasticizing cylinder, said charging cylinder communicating also with the piston injection cylinder via the non-return valve.
Patent PL-326099-A1 (PL)
Title: Polyolefinic composition of low smoke generating poer, articles made of such composition and method of making such articles
Inventor: BECKER RONALD F
IPC: C08K5/526
Filed: 1998-04-30
Abstract: A polymer composition and fiber, film or sheet prepared therefrom, which contains (i) an olefin polymer containing an acid neutralizing agent other than a metallic salt of a saturated or unsaturated fatty acid, and ii) a stabilizer system distributed throughout the polymer, the stabilizer system including (a) a phosphite selected from 2,2',2''-nitriloÄtriethyl-tris(3,3',5,5'-tetra-tert.butyl-1,1-biphenyl -2,2'-diyl)phosphiteÜ and tris(2,4-di-tert-butylphenyl) phosphite; and (b) a N,N-dialkylhydroxylamine. Also disclosed is a method for preparing a polyolefin fiber, film or sheet, which includes adding the above stabilizer to an olefin polymer containing an acid neutralizing agent other than a metallic salt of a saturated or unsaturated fatty acid, thereby producing a stabilized olefin polymer; and extruding the stabilized olefin polymer through a die.
Patent PL-330101-A1 (PL)
Title: Method of making magnetic cores of magnetically soft nanocrystalline alloy and magnetic core obtained thereby especially that for electromagnetic actuators of differential switches of ac class
Inventor: COUDERCHON GEORGES
IPC: H01F1/153
Filed: 1998-12-04
Abstract: Production of a nanocrystalline soft magnetic iron-silicon-boron alloy magnetic core involves crystallization heat treatment of the amorphous alloy at 250-450 degrees C in a transverse magnetic field of rectangular waveform. Production of a magnetic core of nanocrystalline soft magnetic alloy, of composition more than 60 at.% Fe, 10-20 at.% Si, 0.1-2 at.% Cu, 5-20 at.% B and 0.1-10 at.% of one or more of Ti, Nb, Zr, Hf, V, Ta, Cr, Mo, W and Mn, the sum of Si + B being less than 30 at.%, involves crystallization heat treatment of the amorphous alloy at 250-450 degrees C in a transverse magnetic field of rectangular waveform. An Independent claim is also included for a magnetic core produced by the above process and exhibiting, for a 50 Hz alternating excitation magnetic field of 10 mA/cm maximum amplitude at 25 degrees C, an impedance magnetic permeability ( mu z) of greater than 200000, a remnant induction/saturation induction (Br/Bm) ratio of less than 0.2 and  DELTA Bstat and  DELTA Bdyn values of greater than 0.2 T.
Patent PL-337925-A1 (PL)
Title: Pharmaceutic compositions containing an inhibitor of aldosic reductase and an ace inhibitor
Inventor: CAREY FRANK
IPC: A61K31/4188
Filed: 1998-07-02
Abstract: The invention relates to pharmaceutical compositions comprising an aldose reductase inhibitor and an ACE inhibitor, and their use in the treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy and diabetic nephropathy.
Patent PL-345021-A1 (PL)
Title: Methods of inhibiting corrosion using isomers of chloro-methylbenzotriazole
Inventor: ANDERSON SYDIA B
IPC: C07D249/18
Filed: 1999-03-17
Abstract: The use of halo-benzotriazoles as corrosion inhibitors in aqueous systems is disclosed. Specific isomers of chloro-methylbenzotriazole were found to be more effective corrosion inhibitors than tolyltriazole in the presence of chlorine.
Patent PL-347779-A1 (PL)
Title: Modular electric equipment
Inventor: FILSNOEL YANN
IPC: H02B1/20
Filed: 2001-05-29
Abstract: Connection pins (22A,22B) are located inside slots (30A,30B) formed in a face (16) of the plug in modules housing (14). The pins are insulated from the exterior by a protection bridge which extends along the pin alignment and allows insertion of distributor grip contacts (24A,24B). The phase contact (22A) and/or neutral contact (22B) is mounted in an insulating support. The insulating support includes a first tongue receiving the phase connector and a second tongue for the neutral connector. The disconnector includes an insulated housing (14) having a lateral connection face (51) and a back face designed to be fitted to a fixing rail (18), terminals (46) accessible from the face (51), and; at least a conducting pin (22A,22B) extending perpendicularly from the face (16) which engage into grip contacts (24A,24B) on the distributor (12).
Patent PL-359460-A1 (PL)
Title: Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
Inventor: MONNERET CLAUDE
IPC: A61K31/36
Filed: 2001-06-19
Abstract: A compound selected from these of formula (I):wherein:R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono,R2 represents oxygen or sulphur,R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl,X represents linear or branched (C1-C6)alkylene,R4 represents a group selected from amino optionally substituted by one or two groups, -N(R3)-X1-OR5 wherein R3, X1 and R5 are as defined in the description, -N(R3)-X1-NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, -O-X1-OR5 wherein R5 and X1 are as defined in the description, and -O-X1-NR6R7 wherein R6, R7 and X1 are as defined in the description,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.