baber/WOPTO huggingface dataset:
Patent DE-69225616-T2 (DE)
Inventor: SAMELIUS ANDERS
IPC: B23B31/117
Filed: 1992-11-03
Granted: 1998-11-05
Abstract: Rotatable holder for tools and work pieces, in the form of a machine spindle (7) for machine tools and having a clamping device (8) formed as an integral part thereof and being in the form of a hydraulic clamp bushing (8) for tools or work pieces, for instance a chuck, and a method for the manufacture of such a holder, whereby a machine spindle (7) is manufactured separately without any demands on accurate dimensions, and a hydraulic clamp bushing (8) is manufactured separately, likewise without any demands on accurate dimensions, whereupon the spindle (7) and the clamp bushing (8) are weld or solder connected to form an integral unit by means of a weld or solder method transmitting a minimum of heat, whereupon the bearing areas of the spindle (7) and the clamping bore (17) of the clamp bushing (8) are finally worked to accurate dimensions and a high radial rotary precision.
Patent DE-69229480-T2 (DE)
Inventor: FURIHATA KIYOMI
IPC: C07C51/44
Filed: 1992-10-28
Granted: 2000-02-17
Abstract: Eicosapentaenoic acid or an ester thereof, having a purity as high as at least 99 % and being useful for preventing or treating thrombosis, can be obtained in a recovery of 55 % or above by subjecting a mixture of fatty acids or esters thereof obtained from a natural fat or oil containing eicosapentaenoic acid or derivatives thereof to precise fractional distillation in a high vacuum by using a number of, particularly at least three, distillation columns to obtain a fraction mainly comprising C20 fatty acids or esters thereof, and subjecting this fraction to reversed phase column chromatography for fractional purification. <IMAGE>
Patent DE-69230365-T2 (DE)
Inventor: FREYSSINIER PHILIPPE
IPC: H01Q9/04
Filed: 1992-10-27
Granted: 2000-03-23
Abstract: An antenna comprises a first dielectric layer (D1) including on one side an earth-plane (PM1), and on the other a first conductive slab (P1) of chosen shape. A second dielectric layer (D2) surmounts the first on the first slab side, and supports, on the other side, facing the first slab, a second conductive slab (P2) of chosen shape. A third dielectric layer (DR) surmounts the second. The second slab (P2) is of smaller size than that of the first slab (P1), and this first slab (P1) is fed from the bottom, at at least one chosen point (FR1) situated between its centre and its periphery. Advantageously, the first slab (P1) is connected to a run-through (TR1) of the first-plane joining up with a feed circuit (DL1, DL2) implanted in the dielectric substrate of three-plate structure (SDH, SDB). <IMAGE>
Patent DE-69307997-T2 (DE)
Inventor: JANECKE DANIEL PAUL
IPC: F16H61/34
Filed: 1993-11-08
Granted: 1997-05-22
Abstract: Calibration of an X-Y shifter is accomplished under the control of a microcomputer (28) which is programmed to perform a calibration routine each time the vehicle is shutdown. The routine causes the shifter's shift finger (10) to be moved into touching contact with the various inner wall surfaces (11F, 11R, 12F, 12R, 13F, 13R, 11X, 13X) of a plurality of shift blocks (11, 12, 13) of the respective transmission shift rails (14a, 14b, 14c) from which a calibrated shift rail and neutral position are calculated. <IMAGE>
Patent DE-69319955-T2 (DE)
Inventor: CEREDA ENZO
IPC: C07D401/00
Filed: 1993-03-19
Granted: 1999-04-15
Abstract: Crystalline monohydrates of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-ben zimidazole-1-carboxamide hydrochloride and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-ox o-1H-benzimidazole-1-carboxamide hydrochloride of formula <CHEM> (Compound 2a: R = H> (Compound 2b: R = C2H5> the processes for their preparation and pharmaceutical compositions containing them. <IMAGE>
Patent DE-69320268-T2 (DE)
Inventor: GEIBEL JOHN FREDERICK
IPC: C08G75/06
Filed: 1993-06-30
Granted: 1998-12-17
Abstract: A process for preparing poly(arylene sulfide) with reduced metal contamination is produced by contacting a dihaloaromatic compound, a sulfur source, a polar organic compound, and an alkali metal carboxylate in a reaction vessel wherein at least the liquid contacting parts of the vessel are constructed of titanium. In another aspect of the invention a polymer produced by the above described process is provided.
Patent DE-69321196-T2 (DE)
Inventor: ST GERMAIN RONALD E
IPC: H01R13/631
Filed: 1993-10-26
Granted: 1999-03-18
Abstract: An apparatus (10) for positively preventing misengagement of multipoint connector elements includes a mounting rack (26) having a pivot slot (18) and a stepped guide surface (32), along with an associated receptacle element (34) of a multipoint connector. The apparatus (10) also includes a housing (44) having a pivot pin (20) and a stepped guide surface (50), along with an associated plug element (54) of multipoint connector. Only when the pivot pin (20) is fully seated in the pivot slot (18) will the receptacle (34) and plug (54) elements be able to engage. Otherwise, the stepped guide surfaces (32, 50) act to positively prevent such engagement. Also, the stepped guide surfaces (32, 50) are concentrically mated to provide angular engagement and disengagement paths that result in a plurality of plug pin contacts (68) and receptacle socket contacts (70) engaging and disengaging in a sequential order, respectively. <IMAGE>
Patent DE-69329150-T2 (DE)
Inventor: HUGHES N
IPC: A41D31/00
Filed: 1993-05-11
Granted: 2001-02-08
Abstract: A fabric having both a high degree of user comfort and a high degree of Ultraviolet Radiation protection is provided. The preferred yarn is at least 40 Denier by 40 Denier, preferably 70 Denier by 2 70 Denier Nylon Yarn. The yarn is woven into a fabric with a yarn count of at least 80 by 50, preferably about 118 by 68 yarns per inch. The fabric is sanded, preferably moderate to heavy, on one side. The fabric is jet treated, preferably air jet laundered. The fabric provides an Ultraviolet sun protection factor of at least about 30, preferably about 70 or more.
Patent DE-69329821-T2 (DE)
Inventor: ARISON BYRON H
IPC: C07H19/01
Filed: 1993-03-16
Granted: 2001-07-19
Abstract: Avermectin compounds are glycosylated at the 4',13- Or 14a-positions by adding the avermectin compounds to the fermentation medium of a novel strain of Streptomyces avermitilis. The 4'-hydroxy, 13-hydroxy and 14a-hydroxy methyl groups of the avermectin compound are glycosylated with a glycosyl moiety, specifically an oleandrose group. The new strain offers the added advantage of not producing any C5-O-methylation products. The compounds are potent anthelmintic and antiparasite agents, and compositions for such uses are also disclosed. U.S patent 3950360 to Aoki e &cir& _t &cir& _ a &cir& _1 &cir& _, discloses milbemycin compounds and European patent application 242052 to Rudd e &cir& _t &cir& _ a &cir& _1 &cir& _ discloses nemedectin compounds with a 25-hydroxy group and a 25-unsaturated alkyl group.
Patent DE-69408598-T2 (DE)
Inventor: DOLLE ROLAND E
IPC: A61K31/50
Filed: 1994-06-04
Granted: 1998-09-17
Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: <CHEM>  wherein R1 is halogen, oxygen linked leaving group including aromatic ether, aromatic ester, alkyl sulfonate, aryl sulfonate, alkyl phosphonate, aryl phosphonate, alkyl phosphate or aryl phosphate; R2 is OR5, NH(CHR5)m-COOR5, NH(CHR5)mCON(R5)R6, N(R5)R6 or NH(CHR5)nOH;     R3 is H or alkyl;     R4 is H, substituted or unsubstituted aryl, heteroaryl or alkyl; R5 and R6 are independently H, lower alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl or lower cycloalkyl;     m = 1-6; and     n = 2-6. pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1 beta  protease activity in a mammal utilizing the compounds and compositions.
Patent DE-69413271-T2 (DE)
Inventor: VANDERLAAN DOUGLAS G
IPC: G02B1/14
Filed: 1994-03-01
Granted: 1999-04-08
Abstract: An ophthalmic lens for placement on the anterior surface of the eye is disclosed. The lens has impregnated in it or it has coated on its surface an ester of a polyhydric aliphatic alcohol and a fatty acid in which the alcohol residue has at least one hydroxyl group. The ester is present in an amount which is effective to prevent or decrease the release of bacterial toxins when the lens is exposed to those toxins. The lens is particularly well-suited for a soft hydrogel contact lens, and advantageously eliminates, minimizes or prevents keratitis. Bacterial keratitis is an infection of the cornea of the eye which may occur during extended wear of the lens and may cause ulceration of the cornea.
Patent DE-69422849-T2 (DE)
Inventor: SATO SHINICHI
IPC: C09D11/033
Filed: 1994-05-11
Granted: 2000-07-06
Abstract: In an ink-jet recording method employing ink that includes an aliphatic or an alicyclic monohydric alcohol having a vapor pressure of 4 mmHg or less at 20 to 25 DEG C, in which ink droplets are discharged by applying thermal energy onto the ink, and the amount of ink discharged, corresponding to one pulse of energy, is 5 to 20 pl/dot. A recording unit, and ink-jet recording apparatus employing the ink are also included. <IMAGE>
Patent DE-69426563-T2 (DE)
Inventor: VIITANIEMI PERTTI
IPC: F26B3/02
Filed: 1994-05-13
Granted: 2001-08-23
Abstract: PCT No. PCT/FI94/00190 Sec. 371 Date Nov. 9, 1995 Sec. 102(e) Date Nov. 9, 1995 PCT Filed May 13, 1994 PCT Pub. No. WO94/27102 PCT Pub. Date Nov. 24, 1994A method for improving the resistance of cellulosic products against mold and decay, as well as for enhancing the dimensionally stability of the products is disclosed. The cellulosic products are subjected to heat treatment, which is carried out at an elevated temperature. The products are obtained by drying to a moisture content of less than 15%, and keeping the resulting products in a moist atmosphere at a temperature of at least about 150 DEG  C. for 2 to 10 hours until a weight loss of at least 3% has been obtained.
Patent DE-69432219-T2 (DE)
Inventor: UNGER EVAN C
IPC: A61K8/14
Filed: 1994-05-20
Granted: 2003-12-04
Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Patent DE-69432372-T2 (DE)
Inventor: MCADAM KEVIN GERARD
IPC: A24D3/16
Filed: 1994-09-26
Granted: 2003-10-23
Abstract: This invention relates to a method which provides in a cigarette filter element a capsule containing a deodoriser. The capsule is resistant to the handling endured before and during smoking, and is ruptured to release or expose the deodoriser after smoking has occurred and upon extinguishing of the smoked cigarette. The deodoriser may comprise neutralising or masking agents, or mixtures of both. <IMAGE>
Patent DE-69504068-T2 (DE)
Inventor: LONARDI EMILE
IPC: F27B1/20
Filed: 1995-05-05
Granted: 1999-02-25
Abstract: PCT No. PCT/EP95/01704 Sec. 371 Date Feb. 26, 1997 Sec. 102(e) Date Feb. 26, 1997 PCT Filed May 5, 1995 PCT Pub. No. WO95/33858 PCT Pub. Date Dec. 14, 1995A shaft furnace charging device with rotating chute comprises a supporting structure (22) overhanging the shaft furnace (10), a mounting flange (18) fixed rigidly to the shaft furnace (10), a batch hopper (26, 28) supported by the supporting structure (22), a drive housing (30) for the chute (32) which is connected in a sealed manner at one end to the batch hopper (26, 28) and at the other end to the mounting flange (18), and at least one large diameter roller ring (40) mounted in the housing (30) in order to support the chute (32) with the ring (40). In order to increase the working life of the roller ring (40), at least one deformable linking element (70) is incorporated in the chain of rigid elements connecting the mounting flange (18) to the roller ring (40), in such a way that a rigid transmission of deformations of the mounting flange (18) to the roller ring (40) is largely prevented.
Patent DE-69505968-T2 (DE)
Inventor: MALAMAS MICHAEL
IPC: A61K31/421
Filed: 1995-04-13
Granted: 1999-05-12
Abstract: This invention relates to compounds which have oral antihyperglycemic activity of the formula:    <IMAGE>  I  wherein: R1 is C1-C6 alkyl, C3-C8 cycloalkyl, thienyl, furyl, pyridyl,   <IMAGE>   R2 is hydrogen or C1-C6 alkyl; X os O or S; n is 0, 1, or 2; A is   <IMAGE>      <IMAGE>    <IMAGE>   or   <IMAGE>    Y is O or S; Z is N or CH when Y is O and Z is CH when Y is S; or a pharmaceutically acceptable salt thereof.
Patent DE-69513155-T2 (DE)
Inventor: THIOLIERE GEORGES
IPC: B60C27/06
Filed: 1995-03-24
Granted: 2000-06-15
Abstract: PCT No. PCT/FR95/00364 Sec. 371 Date Sep. 24, 1996 Sec. 102(e) Date Sep. 24, 1996 PCT Filed Mar. 24, 1995 PCT Pub. No. WO95/25643 PCT Pub. Date Sep. 28, 1995A tire chain assembly including two stays hinged at one end on a housing and supporting wall chains which hold tread chains in place on the tread of the tire when they are pulled tight as the stays are drawn together by a resilient linkage. Arms or resilient linkages control displacement and vibration of the stays when the wheel is moving. The device enables gripping equipment to be fitted quickly and easily and is suitable for use on snow-covered, muddy, sandy, or vegetation-covered terrain.
Patent DE-69518841-T2 (DE)
Inventor: CHEN L
IPC: A61P25/00
Filed: 1995-06-06
Granted: 2001-01-11
Abstract: PCT No. PCT/IB95/00439 Sec. 371 Date Dec. 6, 1996 Sec. 102(e) Date Dec. 6, 1996 PCT Filed Jun. 6, 1995 PCT Pub. No. WO95/33750 PCT Pub. Date Dec. 14, 1995Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the description, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment of CNS and stress-related disorders.
Patent DE-69519811-T2 (DE)
Inventor: JARVINEN KARI
IPC: H04L1/20
Filed: 1995-01-23
Granted: 2001-07-19
Abstract: The invention relates to a method for processing the parameters of a speech coder according to the quality of the transmission connection. The quality of the transmission connection is determined in a quality monitoring member (409) on the basis of erroneous/error-free classifications of single received frames so that for determining the quality of the transmission connection the classifications of single frames performed during several subsequent speech frames are scanned. On the basis of the quality of the transmission connection both the replacement procedure of erroneous speech frames carried out in the replacement member (402) and the processing of the frames detected as error-free carried out in the processing member (406) of error-free frames are controlled so that the effect of the transmission errors on the quality of the decoded speech signal remains insignificant. <IMAGE>
Patent DE-69535607-T2 (DE)
Inventor: GORFINE STEPHEN R
IPC: A61K31/56
Filed: 1995-04-10
Granted: 2008-07-10
Abstract: A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anaesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.
Patent DE-69601032-T2 (DE)
Inventor: MADSEN LARS
IPC: E06B9/322
Filed: 1996-03-06
Granted: 1999-07-15
Abstract: PCT No. PCT/DK96/00094 Sec. 371 Date Jul. 2, 1997 Sec. 102(e) Date Jul. 2, 1997 PCT Filed Mar. 6, 1996 PCT Pub. No. WO96/27728 PCT Pub. Date Sep. 12, 1996The operating device has an input shaft (20) which by one end is connected with a driving arrangement with a rotatable wheel (17) for receiving an endless cord (8), and which by the other end is coupled to an output shaft (14) which is connected in a rotationally locked manner with the screening arrangement. The input shaft (20) is connected with the output shaft (14) via a transmission shifting device, in particular a planet gear (21). Between the transmission shifting device and the output shaft, a mechanism is engaged for limitation of the transferred driving torque. This mechanism is constituted by a sliding clutch having a first coupling part (25) in connection with the transmission shifting device (21) and a second coupling part (26) in connection with the output shaft (14). The first coupling part (25) may have a toothed shaft (24)and the second coupling part (26) a slotted and toothed rim (27), or vice versa. Furthermore, a brake is provided for retaining the screening arrangement in an arbitrary position.
Patent DE-69601315-T2 (DE)
Inventor: POTIER THIERRY
IPC: G04F10/10
Filed: 1996-02-14
Granted: 1999-06-02
Abstract: The chronometer comprises a clock (1), providing (21) pulses, as a primary event chronometer (CHR1) of close time periods. Logic circuits (22) produce a timing waveform, connecting the time between an event and a known clock impulse. A constant timing circuit (3) receives this timing waveform and produces an electrical signal much longer than the timing wave. This signal is measured (4,5), representing the timed waveform duration, providing a fine measurement of the event time. The logic circuits produce the timing waveform, its start coinciding with the event and ending at "k" clock impulses after the start, with "k" being a positive integer. The constant timing circuit comprises a filter (FAB), the measurement resulting from its response.
Patent DE-69611588-T2 (DE)
Inventor: BERNARD LILIANE
IPC: A22C25/02
Filed: 1996-09-19
Granted: 2001-08-23
Abstract: Fish are placed on individual supports (17) as they pass through a washing tunnel (2) where they are cleaned inside and out. The tunnel (2) is open at either end to allow fish in (3) and out (4). The fish are washed with washing liquid from a number of nozzles (6 to 11) arranged inside the tunnel, spraying inwards. Used liquid is collected in a bath (14) beneath the tunnel and drained away (15).
Patent DE-69619156-T2 (DE)
Inventor: LAURENT PHILIPPE
IPC: A61P25/28
Filed: 1996-05-14
Granted: 2002-08-14
Abstract: Use of a cpd. of formula (I) selected from ( alpha -(tert.-butylaminomethyl)- 3,4-dichlorobenzyl)thioacetamide (Ia) and its laevorotatory (i.e. (-)) isomer, ( alpha -(tert.-amylaminomethyl)- 3,4-dichlorobenzyl)thioacetamide (Ib) and its isomers and ( alpha -(1-adamantylaminomethyl)- 3,4-dichlorobenzyl)thioacetamide (Ic) and its isomers, or their acid addn. salts, is claimed for the prepn. of a dopamine re-uptake inhibiting medicament. In the formula, R = tert.-butyl in (Ia), tert. amyl in (Ib) or 1-adamantyl in (Ic). Also claimed are (-)-(Ia) and its acid addn. salts (specifically the hydrochloride); (Ib) and its isomers and acid addn. salts; and (Ic) and its isomers and acid addn. salts are new cpds.
Patent DE-69625225-T2 (DE)
Inventor: DUBIEF CLAUDE
IPC: A61Q5/10
Filed: 1996-09-16
Granted: 2003-04-17
Abstract: A cosmetic or dermatological composition for treating keratinous material, particularly hair, including a cosmetically or dermatologically acceptable medium containing as least one silicone-grafter polymer with a polysiloxane portion and a portion consisting of a non-silicone organic chain, wherein one of the two portions constitutes the main polymeric chain while the other is grafted onto said main chain, and at least one combination of at least one anionic polymer and at least one cationic polymer. Such compositions are particularly suitable for use as rinsable or non-rinsable products for washing and conditioning hair, hair setting, or hair styling.
Patent DE-69700454-T2 (DE)
Inventor: MATAS GABALDA CARLOS
IPC: D02G1/04
Filed: 1997-02-14
Granted: 2000-05-11
Abstract: PCT No. PCT/FR97/00289 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Feb. 14, 1997 PCT Pub. No. WO97/31141 PCT Pub. Date Aug. 28, 1997A machine for making a mixed yarn by combining two false-twist textured yarns is disclosed. The machine comprises drawing systems (3A, 3B; 8A, 8B) arranged on either side of the texturing area and mounted alternately on two separately controlled parallel, shafts, and heat treatment units (5A, 5B) located in the false twisting area and having a temperature controlled by two mutually separated systems. The false-twist spindles (7) are power spindles with a speed that may be varied to suit each kind of yarn. The machine comprises joining device (9) for interlacing two yarns from two different texturing positions, the device being arranged, when seen from the front, between the positions so that the two yarns (2A, 2B) follow identical paths before being joined.
Patent DE-69705504-T2 (DE)
Inventor: HASSLER G
IPC: D21H17/16
Filed: 1997-03-14
Granted: 2001-10-25
Abstract: PCT No. PCT/EP97/01308 Sec. 371 Date Aug. 19, 1998 Sec. 102(e) Date Aug. 19, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/35068 PCT Pub. Date Sep. 25, 1997Disclosed are a paper size consisting essentially of a) alkyl ketene dimer and/or alkenyl succinic acid anhydride; b) degraded, liquid cationic starch having a cationic charge density of 0.5 to 3.5 meqv/g, a degree of substitution of more than 0.1 and a viscosity of less than 10000 cps (30% by weight solution in water at 25 DEG  C.); and c) water, and a process for making paper products in which this paper size is added to the pulp. The invention allows the production of AKD and/or ASA sizes on-site in paper plants using simple mixing equipment.
Patent DE-69710322-T2 (DE)
Inventor: LOURMAN DIDIER
IPC: B05D7/00
Filed: 1997-04-15
Granted: 2002-08-29
Abstract: PCT No. PCT/FR97/00675 Sec. 371 Date Mar. 8, 1999 Sec. 102(e) Date Mar. 8, 1999 PCT Filed Apr. 15, 1997 PCT Pub. No. WO97/38946 PCT Pub. Date Oct. 23, 1997A process for applying water-based paints and/or varnishes to the surface of a glass article which includes the steps of charging a composition of water-based product to a potential of a given polarity, spraying the composition of the water-based product and diffusing the resulting particles in a wide area so as to form a mist (120, 121), placing the glass article (200) in contact with an electrode at a potential of another given polarity and maintaining its surface temperature between 15 DEG  C. and 30 DEG  C., and bringing the glass article into the field of the mist making it possible to obtain various appearances of coloration in the glass article.
Patent DE-69721731-T2 (DE)
Inventor: TOPALIAN L
IPC: C07K16/18
Filed: 1997-01-30
Granted: 2004-03-18
Abstract: The present invention relates to immortalized, malignant, human, adult prostate epithelial cell lines or cell lines derived therefrom useful in the diagnosis and treatment of prostate cancer. More particularly, the present invention relates to cloned, immortalized, malignant, human, adult prostate epithelial cell lines and uses of these cell lines for the diagnosis and treatment of cancer. Furthermore, the present invention provides for the characterization of said cell lines through the analysis of specific chromosomal deletions.
Patent DE-69732032-T2 (DE)
Inventor: INOUE OSAMU
IPC: B01D71/36
Filed: 1997-08-06
Granted: 2005-11-10
Abstract: A filter medium having excellent efficiency and an air filter unit using the same are provided which have air permeable supporting material (3, 4) on at least one surface of a PTFE porous film (2). The maximum amount of organic materials detected from the filter medium is 3ng or less per gram of the filter medium. <IMAGE>
Patent DE-69733884-T2 (DE)
Inventor: BROCARD BERTRAND
IPC: A01K67/027
Filed: 1997-02-20
Granted: 2006-06-01
Abstract: A DNA fragment coding for a modified nuclear glucocorticoid receptor, particularly one mutated in the region coding for the ligand binding domain, so that receptor activity is more strongly inducible by a synthetic glucocorticoid ligand than by a natural glucocorticoid ligand, is disclosed. A recombination system inducible in mammals by means of a fusion protein produced between a recombinase and the binding domain of the ligand derived from the modified glucocorticoid receptor of which the activity is more strongly inducible by synthetic glucocorticoids than by natural glucocorticoids, is also disclosed.