baber/WOPTO huggingface dataset:
Patent JP-2022024175-A (JP)
Title: Immunogenic compositions and use thereof
IPC: A61K47/04
Filed: 2021-12-03
Abstract: PROBLEM TO BE SOLVED: To provide polysaccharide-protein conjugate vaccines or monoclonal antibodies to confer passive immunity as means to prevent or treat GBS diseases, including those caused by emerging serotype IV, among broad populations worldwide. 
     SOLUTION: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS diseases in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023082894-A (JP)
Title: Pitch guide jig of machine screw driver
Inventor: HORI KAZUO
IPC: B25B21/00
Filed: 2021-12-03
Abstract: To provide a pitch guide jig for a machine screw driver which can be effortlessly attached to machine screw driver bodies of varied shapes and enables its tip to match with a construction reference line even if an orientation of a ruler member is changed to a vertical direction or a lateral direction.SOLUTION: A pitch guide jig 2 includes: an inner cylinder member 3 which is fitted on an area near a tip of a nose part 12 having a machine screw ejection port 11 and fixed; an outer cylinder member 4 which is fitted on the inner cylinder member 3 and held so as to be rotatable 90 degrees around an axis core of the inner cylinder member 3; and a ruler member 5 which is held in a manner that the ruler member 5 can be switched in a vertical orientation or a lateral orientation by rotation of the outer cylinder member 4. The inner cylinder member 3 is fixed so that its axis core matches with an axis core of the ejection port 11. A tip of the ruler member 5 is attached with a guide stick 51 which respectively indicates positions immediately above and immediately lateral to the axis core of the ejection port 11 when the ruler member 5 is held in the vertical orientation and the lateral orientation.SELECTED DRAWING: Figure 1
Patent JP-2022115797-A (JP)
Title: Photographing device, control method thereof, and program
IPC: G06Q50/10
Filed: 2021-12-06
Abstract: PROBLEM TO BE SOLVED: To provide a photographing device, its control method, and a program, which realize electronic applications for administrative procedure and the like by strictly performing identity verification. 
     SOLUTION: A photographing device reads certificate information on an applicant's ID card (identity verification medium) or data in an IC chip by a reading device, a camera, and an IC card reader, and the like, and captures an image for use in an application which is a photograph used in an application procedure with the camera. A same-person determination section B408 of a control section 101 compares the certificate information read from the ID card or an image of a person included in the IC chip with the captured image for use in the application and determines whether or not the person is the same person. An authenticity determination section 402 determines authenticity of the ID card on the basis of information read from the ID card. 
     SELECTED DRAWING: Figure 4 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023084260-A (JP)
Title: Device
Inventor: NAGIRA TOSHIYUKI
IPC: G01F23/296
Filed: 2021-12-07
Abstract: To reduce the work load of water leakage measurement work in an inspection corridor.SOLUTION: A device 20 installed in an inspection corridor to measure the amount of water leakage into a dam body comprises a filtering member 40 which has a filter material 42 having water permeability and receives leaked water flowing down to a water storage tank 11 of a water leakage measuring device 10 for measuring the amount of leakage from an outlet 2 of a pipe 1 through which the water leaked into the dam body flows, and a mounting member 30 for mounting the filtering member 40 to the pipe 1 so that the leaked water flows down to the filter material 42.SELECTED DRAWING: Figure 1
Patent JP-2023084387-A (JP)
Title: Glass transfer device, device for manufacturing glass article and method for manufacturing glass article
Inventor: FUJIWARA KATSUTOSHI
IPC: C03B5/167
Filed: 2021-12-07
Abstract: To reliably inhibit a flange part of a transfer pipe from being worn due to overheat.SOLUTION: A glass transfer device includes: a transfer pipe 7 for transferring a molten glass GM; and a holding brick 8 for holding the transfer pipe 7. The transfer pipe 7 includes: a tubular body part 9 through which the molten glass GM circulates; a flange part 10 installed to the body part 9; and an electrode part 11 for energizing the flange part 10. The flange part 10 is provided with a heat shielding member 18.SELECTED DRAWING: Figure 2
Patent JP-2023084565-A (JP)
Title: Antibody or antigen-binding fragment thereof
Inventor: TANIYAMA YOSHIAKI
IPC: C12N1/21
Filed: 2021-12-07
Abstract: To provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin.SOLUTION: Provided is an antibody or antigen-binding fragment thereof having binding properties against a steric epitope on human periostin, consisting of an amino acid sequence A represented by a specific amino acid sequence and an amino acid sequence B represented by one of three different amino acid sequences different from the amino acid sequence A.SELECTED DRAWING: None
Patent JP-2023086433-A (JP)
Title: Information processing device, information processing method, and information processing program
Inventor: SUDO TAKESHI
IPC: H04L51/52
Filed: 2021-12-10
Abstract: To achieve good information presentation for encouraging decision making and actions of a user.SOLUTION: An information processing device comprises an acceptance unit, a generation unit, and a provision unit. The acceptance unit accepts a fact noteworthy about assertion to a prescribed theme or a post of grounds serving as support of the fact from a user. The generation unit generates visualization information in which information containing logically structured fact and grounds can be displayed on different surfaces of a solid figure per assertion. The provision unit provides the visualization information according to a request from the user.SELECTED DRAWING: Figure 11
Patent JP-2022159980-A (JP)
Title: Health maintenance information providing system and program thereof
Inventor: MIZUNO HIRONORI
IPC: A61B5/00
Filed: 2021-12-14
Abstract: To provide a health maintenance information providing system that allows a manager of an organization to grasp health states of all members at a glance by simply entering an organization name, a manager name, and an analysis period from a terminal without individually entering login IDs and passwords from the terminal.SOLUTION: A health maintenance information providing system connects finger ring-type devices 30 worn on users' fingers, a smartphone 10, a server 100 of an organizational unit biometric information providing site, a manager terminal 77 of a manager (supervisor or doctor) of the users in an organization, and a server 50 of a biometric information analysis site that analyzes biometric information and provides its result via a communication network 60, and provides biometric information from the finger ring-type devices 30 collected by the server 50 of the biometric information analysis site, with only manager identification information from the manager terminal 77, in a format that makes it possible to understand at a glance the biometric information of all the users managed by the manager.SELECTED DRAWING: Figure 8
Patent JP-2023087874-A (JP)
Title: Storage device of flight robot
Inventor: OZA KOICHI
IPC: B64F3/00
Filed: 2021-12-14
Abstract: To provide a storage device of a flight robot (a drone) that is configured to change a battery of the flight robot when the robot returns, which can shorten a time during which the drone stays in the device in order to change the battery.SOLUTION: A storage device 1 comprises a storage part 13 for a battery 30, a battery replacement part 12 comprising XY-linear mechanisms 20 and 21 and a rotating mechanism 19, and a control part 7. The control part, when obtaining information about returning from a drone 2, calculates a predicted time for returning during which the drone returns from a current position to a replacement position in the device, and determines a timing for starting a conveyance of a battery at which a waiting time for the battery is short and executes the conveyance, on the basis of a conveyance time during which the battery replacement part conveys the battery from the storage part to the replacement position.SELECTED DRAWING: Figure 3
Patent JP-2023088091-A (JP)
Title: Engine-driven generator
Inventor: TAKADA TAKUMI
IPC: F02D29/06
Filed: 2021-12-14
Abstract: To protect components involved in starting an engine-driven generator in a state where a kickback is likely to occur.SOLUTION: A battery is charged by a generator to supply electric power to a motor to start an engine. A power supply circuit is connected to the generator and battery to generate and output DC voltage or AC voltage. Detection means detects that the battery has sufficient power supply capacity when starting the engine. Here, "sufficient" means, for example, power supply capacity that allows a piston of the engine to overcome a compression top dead center. Engine ignition is permitted if the battery retains sufficient power supply capacity. On the other hand, if the battery does not hold sufficient power supply capacity, engine ignition is not permitted.SELECTED DRAWING: Figure 4
Patent JP-2022046573-A (JP)
Title: Thermoplastic binder for use in binder jetting additive manufacturing
IPC: B33Y10/00
Filed: 2021-12-16
Abstract: PROBLEM TO BE SOLVED: To provide a solidified metal part additionally manufactured by binder jet printing, and a binder solution. 
     SOLUTION: There is provided a part manufactured by a process of binder jet printing, in which a linkable thermoplastic binder comprises a first polymer strand and a second polymer strand, the first polymer strand includes a first functional group, the second polymer strand includes a second functional group, and the first and second functional groups non-covalently couple the first polymer strand with the second polymer strand. The process of binder jet printing a part also comprises: curing the linkable thermoplastic binder in a printed layer to generate a layer of a green body part; heating the green body part above a first temperature to remove at least a portion of the linkable thermoplastic binder and generate a brown body part; and heating the brown body part above a second temperature to sinter the powder to generate the part. The part is substantially free of char residue. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023091384-A (JP)
Title: Hollow particle and method for producing the same
Inventor: Morimoto ryohei
IPC: C08F8/46
Filed: 2021-12-20
Abstract: To provide hollow particles which do not contain fluorine, and are composed of a light-weight resin component.SOLUTION: Hollow particles contain a shell composed of a polyolefin resin and a hollow part, wherein the polyolefin resin contains an olefin component and an unsaturated carboxylic acid component, the olefin component contains propylene and olefin other than the propylene, the content of the propylene is 60 pts.mass or more with respect to 100 pts.mass of the olefin component, and the content of the unsaturated carboxylic acid component is 0.1-10.0 pts.mass with respect to 100 pts.mass of the olefin component.SELECTED DRAWING: None
Patent JP-2023091450-A (JP)
Title: Control method for mechanical parking facility, mechanical parking facility, and control device for mechanical parking facility
Inventor: ISHIDA MANABU
IPC: E04H6/18
Filed: 2021-12-20
Abstract: To provide a control method of a mechanical parking facility capable of shortening a time required for a control device to start a closing operation of a door after determining to start a door opening operation after the door is opened for a user to enter a getting-in/out room, compared with a conventional method.SOLUTION: In a method of controlling a mechanical parking facility according to one aspect of the present disclosure, a control device performs: a first step of determining whether or not to start the operation after opening a door by controlling a door driving part in a first determination mode; a second step of determining whether or not there is a foreign object in a loading-unloading room on the basis of a detection value by an interior sensor, independent of the detection value by a door peripheral sensor when it is determined to start the operation after opening the door in the first step; and a third step of transmitting a closing operation signal for the door to perform the closing operation to the door driving part when it is determined that there is no foreign object in the loading-unloading room in the second step.SELECTED DRAWING: Figure 8
Patent JP-2022028030-A (JP)
Title: Accounting machine
IPC: G07G1/12
Filed: 2021-12-21
Abstract: PROBLEM TO BE SOLVED: To provide an accounting machine reducing a time from the start of registration processing to the completion of accounting processing. 
     SOLUTION: A commodity sales data processor in an embodiment includes a commodity registration machine and an accounting machine. The commodity registration machine has generation means, determination means, and recording means. The generation means generates registration information for performing accounting processing of a commodity that a shopper is going to purchase. The determination means determines identification information for the purchase of the commodity by the shopper before the generation of the registration information for every commodity the shopper is going to purchase is complete. The recording means records the registration information and the information while associating therebetween. The accounting machine has reading means, accounting processing means, and reception means. The reading means reads identification information. The accounting processing means executes accounting processing according to the operation of the shopper when the identification information has been read by the reading means. The reception means receives the registration information associated with the identification information read by the reading means. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023092234-A (JP)
Title: tire
Inventor: SAKUMA JUNYA
IPC: B60C11/03
Filed: 2021-12-21
Abstract: To provide a tire that can make both braking performance and on-snow performance on a dry-road surface and on a wet road surface compatible.SOLUTION: A tread part 2 comprises: at least one circumferential groove 3 extending continuously along a tire equator C in a tire circumferential direction; a plurality of inclined grooves 4 extending continuously from the circumferential groove 3 to a tread end Te; and a plurality of blocks 5 partitioned by the circumferential groove 3, the inclined grooves 4 and the tread end Te. Each of the plurality of blocks 5 has a plurality of sipes 6 extending along the inclined grooves 4. Each of the plurality of sipes 6 has at least one first sipe positioned at a tire equator C side, at least one second sipe positioned at the tread end Te side, and at least one third sipe positioned, in a tire axial direction, between the first sipe and the second sipe. An end part at the tread end Te side of the third sipe is positioned on an extended line of the second sipe.SELECTED DRAWING: Figure 1
Patent JP-2023094235-A (JP)
Title: Information processing apparatus, method for processing information processing apparatus, and program
Inventor: TOKUDA AKIHIKO
IPC: B41J29/26
Filed: 2021-12-23
Abstract: To easily print a line at the same position as the position of perforation processing or crease processing.SOLUTION: An information processing apparatus has: perforation processing setting means that sets whether to perform perforation processing of providing perforated slits in a physical medium; line setting means that sets whether to print a line at the same position as the position of the perforated slits in the physical medium; and instruction means that instructs a printer to perform the perforation processing and printing of the line according to the settings made by the perforation processing setting means and the settings made by the line setting means.SELECTED DRAWING: Figure 13
Patent JP-2023094458-A (JP)
Title: Information processing device, program, and confidentiality level determination method
Inventor: UETOKO KOKI
IPC: G06F40/279
Filed: 2021-12-23
Abstract: To provide a confidentiality level determination apparatus, program and method to more accurately determine a confidentiality level of a document.SOLUTION: A confidentiality level determination apparatus includes: a role determination unit which determines a role of each of pages constituting a document; a search unit which searches each of the pages for a character string indicating a confidentiality level according to different criteria depending on the determined role; and a confidentiality level determination unit which determines a confidentiality level of the document based on a result of the search.SELECTED DRAWING: Figure 1
Patent JP-2023087615-A (JP)
Title: Wind instrument curved pipe repair assist fixture
Inventor: MATSUKUMA SEIJI
IPC: G10D9/10
Filed: 2021-12-13
Abstract: To solve the problem that there is only a conventional repair method available in which a skilled repair worker fixes a sphere fit to a tip of an iron rod with a vise etc., finds out a concave part by using a sense felt at a tip of a finger, and presses and hits the concave part with a hammer so as to correct the concave, and that the owner of a wind instrument who tries to repair by himself or herself may fail frequently, so that a flaw and a concave may become larger.SOLUTION: The present invention relates to a fixture for allowing an owner to easily correct a concave by himself or herself, and expert technique that a skilled repair worker has is not necessary. The concave can be corrected by inserting and only pressing a concave curved pipe without hitting with a hammer. Anybody can easily correct it with very small force. The fixture can be made of inexpensive gypsum and metal as raw materials since no hitting with a hammer is required so as to save the costs that the person who requires the repair has. Further, the anxiety that the wind instrument to be repaired is left for repair by the repair worker is eliminated.SELECTED DRAWING: Figure 3
Patent JP-2021533690-A (JP)
Title: 通信方法及び関連装置
IPC: H04W48/16
Filed: 2019-08-09
Abstract: 本願は、車車間／路車間通信におけるデータ送信に関連する通信方法及び関連装置を提供する。方法は、以下を含む：端末装置は、アップリンクの第１パラメータ値とサイドリンクの第２パラメータ値とを取得し、端末装置は、第１パラメータ値と第２パラメータ値との間の比較に基づき、被送信アップリンクデータ又は被送信サイドリンクデータを送信することを決定する。本方法の実装を通じて、車車間／路車間通信における車載端末装置は、アップリンク及びサイドリンク送信要件をより良好に満たすことができる。
Patent JP-2022501562-A (JP)
Title: 昇降式ラック付き冷蔵庫
IPC: A47B51/00
Filed: 2020-06-19
Abstract: 本開示は、昇降式ラック、ラック駆動機構、及びラックストローク検出装置を備える昇降式ラック付き冷蔵庫を提供し、ラック駆動機構は、第１の滑車が設けられた駆動出力軸を介してトルクを出力する駆動モータと、少なくとも１組の伝動歯車を含む歯車伝動機構と、ガイドレールと、ガイドレールにスライド可能に接続され、昇降式ラックが固定して接続された支持部材と、第１の滑車に巻き付けられ、他端が支持部材に固定して接続された牽引ロープとを備え、ラックストローク検出装置は、トリガー部が設けられたストロークスイッチと、ストロークスイッチ及び内歯車表面に位置決め部が設けられた伝動歯車のそれぞれと嵌合する連動部材であって、伝動歯車が駆動モータにより位置決め部が連動部材と接触するまで回動駆動されると、連動部材がストロークスイッチのトリガー部をトリガーする連動部材と、を備える。
Patent JP-2022501457-A (JP)
Title: エポキシ樹脂組成物、プリプレグ、及び繊維強化複合材料
IPC: C08J5/24
Filed: 2019-09-20
Abstract: 本発明は、以下の構成成分（Ａ）、（Ｂ）、及び（Ｃ）を含有する、繊維強化複合材料のためのエポキシ樹脂組成物に関する。成分（Ａ）は、少なくとも１つのポリナフタレン型エポキシ樹脂を含有し、成分（Ｂ）は、少なくとも１つの脂環式エポキシ樹脂及び／又はジビニルアレーンジエポキシド樹脂を含有し、並びに成分（Ｃ）は、少なくとも１つのアミン硬化剤を含有する。特定の種類のエポキシ樹脂と硬化剤との特定の組み合わせを含有するこのエポキシ樹脂組成物は、極端な環境条件下で高い耐熱性及び高い曲げ弾性率を提供する。より詳細には、エポキシ樹脂組成物によって製造される樹脂硬化物は、航空機構成部品、宇宙船構成部品、自動車構成部品、人工衛星構成部品、産業用構成部品などに有用である繊維強化複合材料の製造に適するバランスの良い力学特性を提供する。
Patent JP-2021536629-A (JP)
Title: アプリケーションまたはアルゴリズムに固有の量子回路設計
IPC: G06N10/00
Filed: 2019-08-28
Abstract: 特定のアプリケーションまたはアルゴリズムのためのアプリケーションまたはアルゴリズムに固有の量子コンピューティング回路を設計するための手法が提示される。設計コンポーネントは、アプリケーションまたはアルゴリズムの解析に基づいて、量子回路設計において互いの間の直接接続を使用する必要性の定義された可能性閾値を満たすということが決定された量子ビットの対を抽出できる抽出コンポーネントと、量子ビットの対に関連付けられた特性の解析に基づいて、アプリケーションまたはアルゴリズムに使用するための量子回路の回路設計を決定できる設計管理コンポーネント（ＤＭＣ）とを、備えることができる。ＤＭＣは、重み付け方式、および影響を受ける下流の量子ビットの数、量子ビットの対間の２量子ビット・ゲート動作の数、または量子ビットの対が測定に影響を与えるかどうか、あるいはその組み合わせを含む特性によって、量子ビットの対をソートすることができる。ソートに基づいて、ＤＭＣは、直接接続を割り当てる最高の順位の量子ビットの対を選択する。
Patent JP-2021535810-A (JP)
Title: モバイル心臓モニタリングおよび分析
IPC: A61B5/256
Filed: 2019-09-06
Abstract: モバイルコンピューティングデバイスを用いて標準ECGの12個の誘導のうちの1つまたは複数を感知して生成するためのデバイス、システムおよび方法が、本明細書で説明される。いくつかの実施形態では、3つの電極が、モバイルコンピューティングデバイスの上に配置され、それにより、個人は、3つのセンサのすべてを同時に心地よく接触させて、前記モバイルコンピューティングデバイスのディスプレイの上に表示され得る6誘導ECGを生成し得る。いくつかの実施形態では、遂行される分析は、QRS軸およびQRST夾角を決定することをさらに含む。
Patent JP-2021529503-A (JP)
Title: マイクログリッドにおけるレジリエンスの判断
IPC: H02J3/38
Filed: 2019-09-10
Abstract: 本発明は、複数のアセット（１４、１６、１８、２０）を含むマイクログリッド（１０）においてレジリエンスを判断するための方法、配置およびコンピュータプログラム製品に関し、各アセットは、マイクログリッドにおける異なる種類の電気エネルギーサブシステムである。配置は、少なくとも１つの制御ユニット（３０、３２、３４、３６、３８）を備え、少なくとも１つの制御ユニットは、アセットを制御するために用いられる装置（３２、３４、３６、３８）およびこの制御の通信リソースに関する状態データを取得し、状態データに基づいて、マイクログリッドにおける破壊的事象に対応するための複数の機能の各々を支援するために各アセットの健全性および可用性を判断し、かつ、複数の機能を行う際に、マイクログリッドのレジリエンス（ＲＩ）を判断するように構成され、レジリエンスは、破壊的事象に対応するための機能のすべてに関して各アセット（１４、１６、１８、２０）の個別のアセットの健全性および可用性に基づいて判断される。
Patent JP-2021526064-A (JP)
Title: 超音波撮像におけるスペックル低減のための組み合わされた周波数・角度複合
IPC: A61B8/14
Filed: 2019-05-21
Abstract: 本開示は、超音波撮像におけるスペックル低減のための組み合わされた周波数・角度複合に関する。そうした組み合わされた周波数・角度複合は、周波数複合または角度複合のいずれかのみを用いた場合と比較して、乗法的なスペックル低減をもたらしうる。本開示の複合方法は、個々の画像を獲得する時に超音波プローブの全アパーチャを利用でき、ゆえに分解能を妥協しないことができる。開示態様において、超音波プローブが動いている間に超音波画像を取得でき、そして、超音波プローブのポジションおよび配向の測定から超音波画像の相対的なポジションおよび配向を決定できる。特定の態様は、画像獲得中に、撮像中の物体の動きおよびひずみを補正できる。
Patent JP-2022502334-A (JP)
Title: ガラス作製プロセスにおける貴金属製部品の電気化学的侵食を緩和するための装置及び方法
IPC: F27D11/08
Filed: 2019-09-20
Abstract: ガラス物品を成形するための装置及び方法が開示され、上記装置及び方法では、溶融ガラスが耐火性容器内で加熱され、上記耐火性容器は、上記耐火性容器の内部の空間を画定する。貴金属製部品は内部空間に露出する。上記装置は、上記内部空間に露出した第１及び第２の電極を含む。第１の電流を供給するよう構成された第１の電源は、上記第１の電極と上記第２の電極との間に接続される。第２の電源は、上記貴金属製部品と、上記第１の電極及び第１の補助電極のうちの少なくとも一方との間に接続され、上記第１の電流と位相が異なる第２の電流を提供するよう構成される。第３の電源は、上記貴金属製部品と、上記第２の電極及び第２の補助電極のうちの少なくとも一方との間に接続され、上記第１の電流と位相が異なる第３の電流を提供するよう構成される。
Patent JP-2022517480-A (JP)
Title: 装置、方法及びプログラム
IPC: H04W72/04
Filed: 2018-11-08
Abstract: 本開示の実施形態は、ハイブリッド自動再送要求（ＨＡＲＱ）のための方法、デバイス、及びコンピュータ読み取り可能な媒体に関する。端末デバイスでの方法は、ネットワークデバイスからＨＡＲＱフィードバックに関する情報を含むスケジューリングメッセージを受信することと、前記スケジューリングメッセージに従って、前記ネットワークデバイスからデータを検出することと、前記ＨＡＲＱフィードバックに関する情報に基づいて、前記ネットワークデバイスへＨＡＲＱフィードバックを送信することと、を備え、前記ＨＡＲＱフィードバックに関する情報は、ＨＡＲＱフィードバック用の処理ＩＤ、及び前記端末デバイス又は前記処理ＩＤのために送信されたスケジューリングメッセージの前記累計数の少なくとも１つを示す。【選択図】図２
Patent JP-2022507623-A (JP)
Title: 低温硬化が低減されたポリウレタンまたはポリウレタン尿素組成物
IPC: C08G18/42
Filed: 2019-11-14
Abstract: 低温硬化が低減されたポリウレタンまたはポリウレタン尿素組成物であって、ａ）少なくとも１つの１０００～５０００ｇ／ｍｏｌの平均数分子量を有するＡ－Ｂ－Ａタイプのブロック共重合体であって、ポリ（アルキレンオキシド）ジオールと、環状ラクトンまたはエーテルとの反応生成物であり、ポリ（アルキレンオキシド）ジオールは、ブロック共重合体の３０～７０質量％の範囲で存在し、環状ラクトンまたはエーテルは、３０～７０質量の範囲で存在する、少なくとも１つの１０００～５０００ｇ／ｍｏｌの平均数分子量を有するＡ－Ｂ－Ａタイプのブロック共重合体と、ｂ）少なくとも１つのジイソシアネートとの反応生成物である組成物、および関連するその使用。
Patent JP-2022513199-A (JP)
Title: 操作されたチロシンアンモニアリアーゼ
IPC: C12N1/15
Filed: 2019-12-06
Abstract: 本発明は、操作されたチロシンアンモニアリアーゼ（ＴＡＬ）ポリペプチドおよびその組成物を提供する。一部の実施形態では、操作されたＴＡＬポリペプチドは、タンパク質分解に対する感受性を低下させ、酸性ｐＨレベルに対する耐容性を増加させる一方で、増強された触媒活性をもたらすように最適化されている。本発明は、治療および産業目的での、操作されたＴＡＬポリペプチドを含む組成物の利用のための方法も提供する。一部の実施形態では、本発明は、本質的に同じ条件下で野生型ＴＡＬ酵素および／または参照ＴＡＬポリペプチドと比較した場合に、改善された特性を有する、操作されたＴＡＬポリペプチド（本明細書では、「組換えＴＡＬポリペプチド」とも称される）ならびにその生物学的に活性な断片およびアナログを提供する。