baber/WOPTO huggingface dataset:
Patent JP-2001513689-A (JP)
IPC: A61K49/00
Filed: 1998-02-26
Abstract: The conceptual approach consists in acquiring an MR image or spectrum for any pH-sensitive MR property of molecules non-permeable to the membrane. The chemical shift of a nucleus localized in, or in close proximity to, an ionizable group of a non-permeable molecule, is normally used as a "pH informative resonance" in the extracellular space. Several MR methods (CSIC - Chemical shift selective imaging, or SI - spectroscopic image) can be used to determine the spatial distribution of the "informative resonance", and thereby the extracellular pH distribution within the sample. This information is most useful in clinical conditions such as muscular dystrophy, isquemia, tumoral transformation and metastasis, among others.
Patent JP-2001514703-A (JP)
IPC: C21D1/18
Filed: 1998-02-25
Abstract: PCT No. PCT/SE98/00334 Sec. 371 Date Jun. 17, 1999 Sec. 102(e) Date Jun. 17, 1999 PCT Filed Feb. 25, 1998 PCT Pub. No. WO98/40180 PCT Pub. Date Sep. 17, 1998The invention relates to a steel having the following alloy composition in weight-%: 1.4-1.6 (C+N), max. 0.6 Mn, max. 1.2 Si, 3.5-4.3 Cr, 1.5-3 Mo, 1.5-3 W, wherein 6<Weq<9, and Weq=% W+2x% Mo, 3.5-4.5 V, max. 0.3 S, max. 0.3 Cu, max. 1 Co, a total amount of max. 1.0 of Nb+Ta+Ti+Zr+Al, a total amount of 0.5 of other elements, including impurities and accessory elements in normal amounts, balance iron, and with a microstructure substantially consisting of a martensitic matrix and in the matrix 2-15, preferably 5-10 volume-% undissolved hard products having the particle size 0.1-3  mu m, said hard products being of MX-type, where M is V and X is C and/or N, wherein 40-60% of the C and N content of the alloy is bound to vanadium as carbides and/or as carbo-nitrides, and a functional amount of hard products precipitated in the martensitic matrix after solution heat treatment of the steel at a temperature between 1000 and 1225 DEG  C. and tempering at least twice for at least 0.5 h at a temperature between 190 and 580 DEG  C., and the use of the steel for tools for forming and/or cutting operations.
Patent JP-2001514556-A (JP)
Title: 医療用流体セットのドッキングポート
IPC: A61M1/36
Filed: 1998-02-26
Abstract: (57)【要約】
医療用流体セット（１０）は、管セクションを一体に接続して前記セットを形成する少なくとも１つの管コネクタ部品（２０、３０、４０、４３）で相互接続された管セクション（１４、１８、２８、３８、４２、４６）を備える。このセットは、更にセットの少なくとも幾つかの管セクションの端に支持される外部コネクタ（１２、２６，４８，５２）を備える。管コネクタ又は外部コネクタの少なくとも１つは、その一体化した部分として、外部コネクタの少なくとも１つに取り外し自在に封止接続される保持封止部材（５０、６０、５４）を備える。保持封止部材は、セットの流路と流体流通接続をしない。それ故、外部コネクタ用の別体又は繋ぎ紐又は鎖で繋がれた閉鎖キャップを省くことができる。
Patent JP-2000510928-A (JP)
IPC: A61M1/10
Filed: 1997-05-05
Abstract: An apparatus and method for a centrifugal fluid pump for pumping sensitive biological fluids, which includes (i) an integral impeller and rotor which is entirely supported by an integral combination of permanent magnets and electromagnetic bearings and rotated by an integral motor, (ii) a pump housing and arcuate passages for fluid flow and containment, (iii) a brushless driving motor embedded and integral with the pump housing, (iv) a power supply, and (v) specific electronic sensing of impeller position, velocity or acceleration using a self-sensing method and physiological control algorithm for motor speed and pump performance based upon input from the electromagnetic bearing currents and motor back emf-all fitly joined together to provide efficient, durable and low maintenance pump operation. A specially designed impeller and pump housing provide the mechanism for transport and delivery of fluid through the pump to a pump output port with reduced fluid turbulence.
Patent JP-2000515053-A (JP)
Title: スプレーモードが切り替わるシャワーヘッド
IPC: A62D101/22
Filed: 1998-05-04
Abstract: (57)【要約】
２つのプッシュボタンを作動させることにより切り換えることができる２つの異なるスプレーモードを提供し得る可撓性ホースを介して供給されるシャワーヘッドは、供給空間１２と、異なる形式の２つの供給部材と、供給空間１２と２つの供給部材との間の２つの連通通路と、２つの連通通路の各１つを制御するようにされた２つの別個のインターセプトバルブ１３，１４とを有している。各バルブは作動用プッシュボタンに接続されている。前記シャワーヘッドは、更に、バルブレバー１５を有している。該バルブレバー１５は２つのバルブ１３，１４を互いに結合するために該２つのバルブ１３，１４に接続されていて逆の方向に変位をさせるようになっている。好ましくは、インターセプトバルブ１３，１４の各々はピストンバルブであり、該ピストンバルブの上端は作動用プッシュボタンを構成している。好ましくは、供給部材の１つは中空部材からなっており、該中空部材の内面は複数個のスプリンクル供給ホース１９と、装置の他の部位へ取り付ける手段のためのシートとを表しており、また、中空部材は、中央に、ジェット曝気装置２３を収容するべくシートを有している。このシャワーヘッドは、低減された高さでもって作ることができ、また、それの組み立て及び分解が容易である。
Patent JP-2002506463-A (JP)
IPC: A61P43/00
Filed: 1999-04-23
Abstract: Methods and compositions for restoring diuretic and renal function comprising adenosine A1 antagonists.
Patent MX-155984-A (MX)
Inventor: ANCILLOTTI FRANCESCO
IPC: C07C43/04
Filed: 1983-02-25
Abstract: In producing t-butyl alkyl ethers by etherifying with aliphatic alcohols isobutene in a hydrocarbon feedstock containing butadiene in addition to the isobutene, the increase in the pressure drop in the etherification reactor(s) that is due to the butadiene is eliminated by feeding the reactants from the bottom upwards. The reactors preferably contain an acidic ion-exchange resin catalyst.
Patent NZ-196349-A (NZ)
Title: Enhancement of absorption rate of orally administered polar bioactive agents
Inventor: HIGUCHI T
IPC: A61K31/60
Filed: 1981-02-25
Abstract: A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaromatic, hydroxyaryl or hydroxy aralkyl acid or salt amide or ester thereof. The hydroxy aryl or hydroxy aralkyl acid or salt amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the polar bioactive agents.
Patent NZ-201690-A (NZ)
Title: Naphthalenes and benzofused heterocyclic compounds and pharmaceutical compositions
Inventor: CROSS P E
IPC: C07D405/12
Filed: 1982-08-24
Abstract: Compounds of the formula: 
<CHEM>
 wherein
 R<1>, which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
 Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
 X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
 and
 R, which is attached to carbon atom of ring "B", is a group of the formula: 
<CHEM>
 where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
 and the pharmaceutically, acceptable salts thereof. 
<??>The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.
Patent NZ-207394-A (NZ)
Title: Detecting or determining sequence of amino acids
Inventor: GEYSER H M
IPC: C12Q1/70
Filed: 1984-03-06
Abstract: A method of detecting or determining a sequence of amino acids which is antigenically active within a known amino acid sequence of a protein or portion thereof comprises the steps of: synthesising a plurality of peptides, each of said peptides comprising a sequence of a plurality of amino acids which corresponds to a sequence within the known amino acid sequence, and the said peptides having overlapping amino acid sequences; contacting each of said peptides with antibody against the protein or portion of interest; and detecting or determining the presence or absence of an antigen-antibody reaction between each of said peptides and said antibody to indicate whether or not said peptide has antigenic activity.
Patent NZ-213651-A (NZ)
Title: Tetrahydronapthalene derivatives and medicaments
Inventor: RAMUZ H
IPC: C07C323/30
Filed: 1985-09-30
Abstract: Tetrahydronaphthalene derivatives of the formula    <IMAGE>  I wherein Y, m, n, R and R1 to R9 are as set forth herein, are described. These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula   <IMAGE>  with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.
Patent NZ-214320-A (NZ)
Title: Benzoxazol- and benzothiazolamine derivatives and pharmaceutical compositions
Inventor: STOKBROEKX R A
IPC: A61K31/46
Filed: 1985-11-25
Abstract: Novel benzoxazol- and benzothiazolamine derivatives of the formula   <CHEM>  wherein L represents C1-12 alkyl, substituted C1-6 alkyl, aryl C2-6 alkenyl, C3-6 cycloalkyl, substituted C3-6 cycloalkyl, a radical of formula <CHEM>  and a radical of formula <CHEM> the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are antianoxic and anti-hypoxic agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
Patent NZ-215035-A (NZ)
Title: Screw cap, stop ring attached to tamper-indicating band by a curved hinge portion
Inventor: GREGORY JAMES LEWIS
IPC: B65D41/34
Filed: 1986-02-04
Abstract: A one-piece molded closure of plastic which threads onto a container with a fairly specific exterior configuration and provides a combination such that when the closure is unthreaded, a tamper-indicating ring becomes separated from the lower end of the closure skirt. The indicating ring or band is joined to the closure by frangible bridges and a flexible stop ring is formed within the band and extends inwardly and upwardly when the closure is applied to a container finish. The container finish has a first radial bead and an inwardly tapering side wall surface therebeneath which leads to an abrupt, inwardly extending ledge. The flexible stop ring rests on the tapered surface, when the closure is applied. After closure removal, the stop ring and band drops below the ledge indicating that the closure has been removed.
Patent NZ-225648-A (NZ)
Title: Apparatus for setting precious stones with exchangeable press elements to position the stones and set the setting claws
Inventor: MAGNIEN E G
IPC: A44C17/04
Filed: 1988-08-02
Abstract: This invention relates to a device for mechanically setting a plurality of small precious stones in a jewel setting having a flat face, which device comprises an upwardly open dish element fixed on a horizontal table, a cover which fits with a very small clearance in the dish element and is centered therein, tools for driving in and setting the stones which are fixed beneath the cover and a jewel setting support which is fixed in the bottom of the dish element.
Patent NZ-229909-A (NZ)
Title: Preparation of optionally active 3,4-disubstituted phenylalanine
Inventor: CANNATA VINCENZO
IPC: C07C227/32
Filed: 1989-07-11
Abstract: New process for the synthesis of optically active aminoacids of formula <CHEM> wherein R and R1, equal or different,represent a hydrogen atom or an alkyl radical, straight or branched, containing from 1 to 6 carbon atoms, by reacting compounds of formula <CHEM> wherein R and R1 have the above seen meanings, R2 represent a nitrile group or a COR4 group wherein R4 represents hydroxy or halogen or alkoxy, straight or branched,containing from 1 to 6 carbon atoms,or a OCOR5 wherein R5 represents an alkyl or an alkoxy group, straight or branched, containing from 1 to 6 carbon atoms and R3 represents hydrogen, an alkyl or an alkoxy radical, straight or branched, containing from 1 to 6 carbon atoms or an aryl or aralkyl radical, with an optically active alcohol of formula  R6-OH      (III)  d or l wherein R6 represents an alkyl or cycloalkyl group, substituted or unsubstituted, containing from 3 to 12 carbon atoms, to obtain a pair of diastereoisomer esters of formula <CHEM> which is resolved in basic medium into the single diastereoisomer esters of formula <CHEM> from which the desired optically active aminoacid of formula (I) is obtained by treatment in acid medium.
Patent NZ-232043-A (NZ)
Title: Production of shaped ceramic bodies comprising metal borides from a moulded preform
Inventor: CLAAR TERRY DENNIS
IPC: C04B35/65
Filed: 1990-01-08
Abstract: This invention relates generally to a novel method of preparing self-supporting bodies, and novel products made thereby. In its more specific aspects, this invention relates to a method for producing self-supporting bodies comprising one or more boron-containing compounds, e.g., a boride or a boride and a carbide, by reactive infiltration of molten parent metal (10) into a preform (20) comprising boron carbide or a boron donor material combined with a carbon donor material and, optionally, one or more inert fillers, to form the body. Specifically, a boron carbide material or combination of a boron donor material and a carbon donor material, and in either case, optionally, one or more inert fillers, are sedimentation cast, slip cast or pressed onto or into a body and into a particular desired shape.
Patent NZ-232479-A (NZ)
Title: Granular automatic dishwashing detergent containing an insoluble inorganic zinc salt
Inventor: CILLEY WILLIAM AJALON
IPC: C11D3/00
Filed: 1990-02-12
Abstract: Disclosed are granular automatic dishwashing detergent compositions containing an insoluble inorganic zinc salt useful for inhibition of glassware corrosion in the dishwasher. These compositions are particularly desirable because use of them in the dishwasher does not result in precipitation of zinc insolubles on the dishware or dishwasher parts.
Patent NZ-233884-A (NZ)
Title: Peroxide bleaching of ligno-cellulose-containing pulp: pretreatment with a complexing agent for trace metals
Inventor: LUNDGREN PER G
IPC: D21C9/147
Filed: 1990-05-31
Abstract: The invention relates to a process for bleaching chemically delignified lignocellulose-containing pulp, to render more efficient a peroxide-containing treatment stage, by treating the pulp with a complexing agent before the peroxide step, so that the trace metal profile of the pulp is altered by the treatment with the complexing agent, in the absence of sulphite, at a pH in the range from 3.1 up to 9.0 and at a temperature in the range from 10 DEG C up to 100 DEG C, whereupon, in a subsequent step, the treatment with a peroxide-containing substance is carried out at a pH in the range from 7 up to 13, said two-step treatment being carried out at an optional position in the bleaching sequence applied to the pulp.
Patent NZ-244158-A (NZ)
Title: Method and apparatus for converting hazardous waste into a non-hazardous aggregate
Inventor: KENT JOHN M
IPC: B09B3/00
Filed: 1992-08-31
Abstract: Apparatus for converting hazardous waste into non-hazardous, non-leaching aggregate comprises means (10) for burning the hazardous waste to produce particulate solid materials, volatile gases and gaseous combustion by-products, oxidising means comprising at least one refractory-lined water-cooled, metal-walled vessel (26), means (76) for introducing the particulate solid materials, volatile gases and gaseous combustion by-products into the oxidising means (26), means (36,38) for inducing combustion in the oxidising means (26), the heat of combustion forming molten slag and non-combustible fines from non-combustible material. The slag (40) is accumulated at the bottom of the oxidising means (26). The non-combustible fines are accumulated in an accumulator (84) and introduced through conduits (102,103,105) into the molten slag to form a substantially molten mixture. An injector (117) is arranged to inject the non-combustible fines into the molten slag beneath its surface. The molten mixture is then removed into a slag box (108) and is cooled by cooling means (106) to form the non-hazardous aggregate.
Patent NZ-249755-A (NZ)
Title: Heterocyclically-substituted indole derivatives, intermediates and pharmaceutical compositions thereof
Inventor: MACOR JOHN E
IPC: C07D417/14
Filed: 1993-05-03
Abstract: PCT No. PCT/US93/01667 Sec. 371 Date Aug. 19, 1994 Sec. 102(e) Date Aug. 19, 1994 PCT Filed Mar. 3, 1993 PCT Pub. No. WO93/18032 PCT Pub. Date Sep. 16, 1993   <IMAGE>  (I)  Compounds of the formula (I) where A represents a direct bond, C1-C4 alkyl, or C1-C4 alkenyl; n is 0, 1, or 2; W, X, Y, and Z are each independently oxygen, sulfur, nitrogen or carbon, provided that at least one of W, X, Y, or Z is nitrogen. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.
Patent NZ-253115-A (NZ)
Title: Gas-containing microparticles; method of production and use as contrasting agents in ultrasonic diagnosis
Inventor: STEIN MICHAEL
IPC: A61K49/22
Filed: 1993-06-05
Abstract: The invention concerns contrasting agents for use in ultrasonic diagnostic, the contrasting agents consisting of gas-containing microparticles with shells made of polycyanoacrylates or polyesters of $g(a)-, $g(b)-, or $g(g)-hydroxycarboxylic acids. The invention also concerns a method of producing such contrasting agents.
Patent NZ-261571-A (NZ)
Title: Producing correctly folded proteins using multiple denaturation and renaturation cycles
Inventor: THOGERSEN HANS CHRISTIAN
IPC: C12P21/02
Filed: 1994-02-04
Abstract: A novel, generally applicable method for producing correctly folded proteins from a mixture of misfolded proteins, e.g. bacterial inclusion-body aggregates. A major new aspect of the method is that over-all efficiency is achieved by subjecting proteins to a time-sequence of multiple denaturation-renaturation cycles, resulting in gradual accumulation of the correctly folded protein. The method has proven efficient for a variety of recombinant proteins. Also provided are novel encrypted recognition sites for bovine coagulation factor Xa. The encrypted recognition sites described may be activated in vitro by controlled oxidation or by reversible derivatization of cysteine residues and thereby generate new cleavage sites for factor Xa. Two new recombinant serine protease exhibiting narrow substrate specificity for factor Xa recognition sites are also provided. They may replace natural coagulation factor Xa for cleavage of chimeric proteins.
Patent NZ-262047-A (NZ)
Title: Compositions and methods for decomposing hydrogen peroxide on contact lenses; contact lens disinfection
Inventor: COOK JAMES N
IPC: C12S9/00
Filed: 1994-02-09
Abstract: The invention provides a process for the preparation of a tablet composition suitable for destroying substantially all of the hydrogen peroxide remaining after disinfecting a contact lens with a hydrogen peroxide solution, the tablet composition being a compressed tablet containing a non-mammalian derived catalase, but excluding tablets consisting of 1mg of A. niger catalase-R and a sorbitol carrier; which process comprises subjecting the catalase to conventional compression tableting conditions to produce a compressed tablet in which the stability of the catalase is greater than the stability of bovine catalase when subjected to the same conventional compression tableting.
Patent NZ-262476-A (NZ)
Title: Clothing article; comprises one or more pieces of fabric gathered within a member and releasably held together at predetermined ends so as to hang about a wearer
Inventor: CLUTTON GEOFFREY
IPC: A41F17/00
Filed: 1994-03-17
Abstract: PCT No. PCT/GB94/00543 Sec. 371 Date Sep. 28, 1995 Sec. 102(e) Date Sep. 28, 1995 PCT Filed Mar. 17, 1994 PCT Pub. No. WO95/04482 PCT Pub. Date Feb. 16, 1995An article of clothing which comprises one or more pieces of fabric which are gathered within a member and releasably held together at predetermined ends by weighted attachment means thereby securing the article of clothing about an individual and allowing the material to hang in an attractive manner.
Patent NZ-298074-A (NZ)
Title: Use of alpha,alpha'-iminobis(methylene)bis[2-chromanmethanol] derivatives for treating degenerative diseases of the vascular or nervous systems
Inventor: DE COURCELLES DIDIER ROBERT GU
IPC: A61K31/352
Filed: 1995-12-21
Abstract: These derivatives are of the formula shown wherein R1 and R3 each are independently Fl, OH or H; R2 and R4 are independently H or OH; and each asterisk indicates a stereogenic center.  The preferred compound is nebivolol.  Suitable diseases that may be treated include atherogenesis, atheromatosis, arteriosclerosis, antherosclerosis, vascular hypertrophy associated with hypertension, hyperlipoproteinemia, vasculopathology of the gonads and pancreas, parathyroidal reactive hyperplasia, chronic renal disease, neoplastic diseases and in inflammatory diseases.
Patent NZ-299853-A (NZ)
Title: Child resistant container has attachment with finish portion attached to container by outer securement device, closure & pushtabs
Inventor: HAMILTON PETER WORTHINGTON
IPC: B65D41/04
Filed: 1993-01-19
Abstract: A child resistant attachment for containers used for storing and dispensing potentially dangerous materials, such as medicament tablets or the like, the attachment being resistant to opening by children but readily openable by adults, particularly adults having impaired manual dexterity of their hands and/or fingers. In a particularly preferred embodiment, the attachment comprises a finish portion including thread ring with an integrally molded annular tab ring or collar generally concentric to the thread ring and a closure which is releasably secured to the thread ring by means of complementary screw threads. The tab ring or collar preferably includes a pair of resiliently deformable spring-like pushtabs containing vertical extensions which engage interlocking pawls on the innermost surface of the closure skirt when the closure is fully assembled onto the finish portion. To remove the closure, the opposed pushtabs must be depressed prior to applying unscrewing torque to the closure to disengage the pushtab extensions from the interlocking pawls on the closure. In a particularly preferred embodiment, the finish portion of the child resistant attachment of the present invention is integrally molded with the container in a ready to use configuration without the need for additional assembly or molding operations. Methods for producing the child resistant attachment and child resistant packages employing it are also disclosed.
Patent NZ-302723-A (NZ)
Title: Composition comprising monoamine oxidase b inhibitor and a carrier formulated for pre-gastric absorption of the monoamine oxidase b inhibitor
Inventor: BREWER FRANCESCA MARY
IPC: A61K9/20
Filed: 1996-03-01
Abstract: A fast dispersing solid pharmaceutical composition having a monoamine oxidase B inhibitor as the only active ingredient is disclosed for the treatment of Parkinson's disease. The composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membranes, such that at least 5% of the active ingredient is absorbed in one minute, as determined by a buccal absorption test.
Patent NZ-307089-A (NZ)
Title: Alpha substituted pyrimidine thioalkyl and alkylether compounds and medicaments
Inventor: NUGENT RICHARD A
IPC: A61K31/506
Filed: 1996-05-03
Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I <CHEM> and pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds of Formula I where R4 is selected from the group consisting of -H or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R6 is selected from the group consisting of -H, or halo (preferably -CI); with the overall provisio that R4 and R6 are not both -H; The compounds of Formula IA are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase.