Patent SG-11201906161V-A (SG)
Title: Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
Inventor: FALB DEAN
IPC: A61K35/74
Filed: 2018-01-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIPO I PCT ill mu °million °nolo Oil Oil mo Ho IIIII m 111110 oimIE (10) International Publication Number WO 2018/129404 Al (51) International Patent Classification: A61K 35/74 (2015.01) Cl 2N 15/74 (2006.01) C12N 15/70 (2006.01) (21) International Application Number: PCT/US2018/012698 (22) International Filing Date: 05 January 2018 (05.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/443,639 06 January 2017 (06.01.2017) US 62/443,634 06 January 2017 (06.01.2017) US PCT/US2017/013072 11 January 2017 (11.01.2017) US 62/531,784 12 July 2017 (12.07.2017) US 62/543,322 09 August 2017 (09.08.2017) US 62/552,319 30 August 2017 (30.08.2017) US 62/592,317 29 November 2017 (29.11.2017) US 62/607,210 18 December 2017 (18.12.2017) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/ 129 40 4 Al (71) Applicant: SYNLOGIC, INC. [US/US]; 200 Sidney Street, #320, Cambridge, MA 02139 (US). (72) Inventors: FALB, Dean; 180 Lake Street, Sherborn, MA 01770 (US). KOTULA, Jonathan, W.; 345 Washington Street, Somerville, MA 02143 (US). ISABELLA, Vincent, M.; 465 Putnam Avenue, Unit 1, Cambridge, MA 02139 (US). MILLER, Paul, F.; 39 Emerald Glen Lane, Salem, CT 06420 (US). FISHER, Adam; 240 Sidney Street, Apt. 306, Cambride, MA 02139 (US). MILLET, Yves; 15 Fred- erick Street, Newton, MA 02460 (US). LI, Ning; 322 Cam- bridge Street, Winchester, MA 01890 (US). LORA, Jose, M.; 45 Province Street, Apt. 902, Boston, MA 02108 (US). MACHINANI, Suman; 18 Centre Street, Apt. 302, Cam- bridge, MA 02139 (US). SAHA, Saurabh; 44 Carisbrooke Road, Wellesley Hills, MA 02481 (US). (74) Agent: HANLEY, Elizabeth, A. et al.; McCarter & Eng- lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNE MODULATORS AND ANTI-CANCER THERA- PEUTICS IN TUMOR CELLS (57) : Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.