Patent SG-11201804915R-A (SG)
Title: Methods for treating huntington's disease
Inventor: BABU SURESH
IPC: A61P25/00
Filed: 2016-12-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 11111 011101011101110111 OH III 111110 ill OEN International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/100726 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/506 (2006.01) A61P 25/00 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 405/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2016/066042 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 11 December 2016 (11.12.2016) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/265,652 10 December 2015 (10.12.2015) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PTC THERAPEUTICS, INC. [US/US]; 100 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Corporate Court, South Plainfield, NJ 07080 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) TJ, TM), Inventors: BABU, Suresh; 225 Concord Place, Penning- European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, ton, NJ 08534 (US). BHATTACHARYYA, Anuradha; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 115 Inverness Drive, Edison, NJ 08820 (US). HWANG, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Seongwoo; 227 Suttons Lane, Edison, NJ 08817 (US). SM, GW, KM, ML, MR, NE, SN, TD, TG). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, JANE Minakshi; 29 Kiva Street, Iselin, NJ 08830 (US). MOON, Young-choon; 11 Edgewood Drive, Belle Mead, Published: NJ 08502 (US). SYDORENKO, Nadiya; 37 Sycamore with Place, Princento, NJ 08540 (US). international search report (Art. 21(3)) (74) Agents: SCOLA, Daniel, A., Jr. et al.; Hoffmann & Bar- on, LLP, 6900 Jericho Turnpike, Syosset, NY 11791 (US). (54) Title: METHODS FOR TREATNG HUNTINGTON'S DISEASE W A 41111.1.1CP , \"s r .- X....... / N — N (I) ,tD ei IN © © ,-1 IN 1-1 (57) : The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using 0 such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present descrip - N tion relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and 0 methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.