baber/WOPTO huggingface dataset:
Patent PT-1843757-E (PT)
Title: Phantom phenomena treatment
Inventor: KNIPPER-BREER MARLIES
IPC: A61P25/00
Filed: 2006-01-19
Abstract: Use of a compound (I) interacting with brain-derived nerve growth factor (BDNF)-signal transduction cascade for the production of a medicament to treat phantom phenomena of acute tinnitus and/or phantom pain in human or animal. Independent claims are also included for: (1) diagnosing phantom phenomena of the acute tinnitus and/or phantom pain in human or animal, comprising supplying a biological sample, determining the level of the expression of BDNF in the biological sample, comparing the level with a reference value from a healthy organism, and correlating a level lying over the healthy organism with a positive diagnosis; and (2) treating phantom phenomena of the acute tinnitus and/or phantom pain in human or animal, comprising supplying a medicament that exhibits a substance interacting with BDNF signal transduction cascade, and applying the medicament locally to the organism, and optionally repeating the method. ACTIVITY : Auditory; Analgesic. MECHANISM OF ACTION : Brain-derived nerve growth factor (BDNF)-signal transduction cascade blocker; BDNF-signal transduction cascade inhibitor; Gamma aminobutyric acid receptor agonist; L-type-Ca ++>-channel antagonist; Cyclic adenosine monophosphate response element binding protein (CREP) antagonist; Glutamate antagonist; Mitogen activated protein-kinase-inhibitor; Calmodulin-dependent kinase-inhibitor; Tyrosine kinase linked receptor (trkB) antagonist. The ability of (I) to inhibit BDNF-signal transduction cascade was tested in cochlea. (I) Significantly removed the expressions of BNDF Exon-IV.
Patent PT-1868599-E (PT)
Title: Antitumor combination comprising substituted acryloyl distamycin derivatives and antibodies inhibiting growth factors or their receptors
Inventor: GERONI MARIA CRISTINA
IPC: A61K31/40
Filed: 2006-03-29
Abstract: The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-homo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antibody inhibiting a growth factor or its receptor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
Patent PT-1898760-E (PT)
Title: Toaster
Inventor: LEAMAN KEITH
IPC: A47J37/08
Filed: 2006-07-03
Abstract: A variable-width toaster is described, in which the food-supporting carriage (5, 60) adapts readily, robustly and in a cost-effective manner to different width settings of the toasting chamber (2, 70). Respective elongate members (51, 52; 61, 62) are mounted to either side of the toasting chamber and are linked together by linking members (53a-53n; 63a, 63b) which form part of the food-supporting surface and are pivotally attached to the elongate members to accommodate lateral relative movement between the elongate members as the width of the toasting chamber is varied. In one embodiment, unitary linking members (53a-53n) link the two elongate members (51, 52) and the elongate members are urged apart by a spring (54). In another embodiment, chevron-like linking members, comprising pairs of pivotally associated linking members (63a, 63b) are employed.
Patent PT-1857238-E (PT)
Title: Saw tooth with hard layer
Inventor: OTTENWAELDER ADALBERT
IPC: B23C5/08
Filed: 2007-01-31
Abstract: The sawtooth (1) has a base body (2) made from a solderable hard metal, and a hard layer (3) made form a material, which is harder than the hard metal of the base body. The hard layer is provided at a front surface (20) of the base body and has different thicknesses, where the tooth face (10) has an angular and/or rounded surface section. A bevel is provided at a rear of the tooth and/or at the tooth face, where the material of the hard layer is diamond having a polycrystalline form.
Patent PT-1916344-E (PT)
Title: Actuation device for a cistern
Inventor: WESSEL HEINZ-WERNER
IPC: F16C1/10
Filed: 2007-10-10
Abstract: The device has an actuating plate (1) and at least two Bowden cable flexible force transfer elements for transferring the movement of an actuating button to at least one valve trigger element. It has a force converter between each Bowden cable and actuating button for converting the button pressure into a traction force and a holder with at least one clip element for reversible connection to the actuating plate.
Patent PT-2055222-E (PT)
Title: Mop holder and corresponding mop cover
Inventor: SALMON DIRK
IPC: A47L13/20
Filed: 2008-10-29
Abstract: The holder has longitudinal and laminar supports (10) for a mob cover, and forming wisp contact surfaces on opposite laminar sides of the supports. The supports comprise a magnetic fixing device i.e. magnet (17) for fixing the mob cover on the holder, and the magnet produces magnetic force on the wisp contact surfaces in a region of the holder. The magnet comprises a counter piece made of ferrite metal for the magnet in the mop cover, and is corrosion-resistant and provided with a plastic casing.
Patent PT-2306425-E (PT)
Title: Device and method for detecting wheel axles
Inventor: NAGY OLIVER
IPC: G08G1/04
Filed: 2009-10-01
Abstract: The device (1) has a sensor (5) operated according to a light-section procedure to emit light (9) from a location along a roadway to project a line of light (10) onto the roadway and a vehicle located on the roadway. The sensor records line of light from next location along the same side of the roadway, and detects wheel axle during exhibition of recorded line of light. The shift-free change of light is realized in the direction different from original direction when the roadway is empty during emanation of light from the side of roadway.
Patent PT-630380-E (PT)
Inventor: LUDESCHER JOHANNES
IPC: C07D501/00
Filed: 1992-12-21
Abstract: The invention relates to a new process for the production of pharmaceutically active cephalosporines by depletion of 7-amino-3-Ä(E)-1-propen-1-ylÜ-3- cephem-4-carboxylic acid in mixtures of 7-amino-3-Ä(Z)-1-propen-1-ylÜ-3- cephem-4-carboxylic acid and 7-amino-3-Ä(E)-1-propen-1-ylÜ-3-cephem-4-carboxylic acid, by means of a metal or amine salt of 7-amino-3-Ä(Z/E)-1-propen-1-ylÜ-3-cephem-4-carboxylic acid.
Patent PT-658622-E (PT)
Inventor: HINNEN ALBERT
IPC: C12N1/19
Filed: 1994-12-08
Abstract: The present invention discloses DNA molecules comprising a gene encoding yeast acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Mutations confering soraphen A resistance to acetyl-CoA carboxylase can be dominant or recessive, and they can be point mutations, deletion or insertion mutations. In addition methods of isolating a gene encoding fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition are provided as well as methods for purifying fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Purified enzyme can be used in assays to identify inhibitors of soraphen A resistant acetyl-coenzyme A carboxylase.
Patent PT-760863-E (PT)
Inventor: STAHL STEN
IPC: C12N1/21
Filed: 1995-05-24
Abstract: Isolated strains of supercapsulated streptococci band at a density of no greater than 1.03 g/cm<SUP>3 </SUP>in a Percoll gradient and are capable of producing hyaluronic acid with molecular weight exceeding 6 million Da. Methods of producing high molecular weight hyaluronic acid employ a supercapsulated strain of streptococcus which bands at a density of no greater than 1.03 g/cm<SUP>3 </SUP>in a Percoll gradient. Methods of selecting streptococcus strains capable of producing hyaluronic acid with a molecular weight exceeding 6 million Da comprise, inter alia, cultivating supercapsulated strains of streptococci which band at a density of no greater than 1.03 g/cm<SUP>3 </SUP>in a Percoll gradient.
Patent PT-765185-E (PT)
Inventor: BLANCHE PAUL
IPC: B01D39/10
Filed: 1995-06-16
Abstract: PCT No. PCT/AU95/00351 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Jun. 16, 1995 PCT Pub. No. WO95/35145 PCT Pub. Date Dec. 28, 1995An apparatus and method for separating material which includes solid and/or particulate matter from flowing liquid and/or gas. The apparatus includes a separation panel positioned in a fluid flow path, and the separation panel is housed in a separation chamber. Fluid can be introduced into the separation chamber by an inlet to establish a circular flow of the fluid within a confine of the separation panel, so material entrained in the fluid is trapped within the confine of the separation panel. The separation panel, separation chamber and inlet can be dimensioned and disposed such that as the apparatus operates, the flow of the fluid outside the separation panel is in a direction opposite to a direction of the flow of the fluid within the separation panel. The separation panel can include plural deflection means for deflecting material entrained in the fluid away from the openings, and the deflection means are generally opposed to a direction of the flow of the fluid, each opening having one of the deflection means associated therewith.
Patent PT-772675-E (PT)
Inventor: WUBBEN MARIA ANNA
IPC: C12C11/11
Filed: 1995-08-03
Abstract: The invention provides pectins as new foam stabilizers for (temporary) foam heads in beverages, in particular in beers, especially beers of the pilsner type. These foam stabilizers are preferably obtained from hops, which is a constituent that is inherent in beer and accordingly offers the advantage, among others, that the foam stabilizers need to have no negative effect on the taste of the beer. Preferably, the pectins are obtained from hop cones or bines. It may be advantageous to partially saponify (de-esterify) the pectins, in connection with the number of charged groups on the pectins. In addition, the invention provides methods for obtaining the pectins and beverages stabilized with the pectins according to the invention.
Patent PT-822839-E (PT)
Inventor: CALLEGARO LANFRANCO
IPC: A61K35/12
Filed: 1996-04-25
Abstract: PCT No. PCT/EP96/01734 Sec. 371 Date Oct. 22, 1997 Sec. 102(e) Date Oct. 22, 1997 PCT Filed Apr. 25, 1996 PCT Pub. No. WO96/33750 PCT Pub. Date Oct. 31, 1996Artificial human skin is disclosed which is based on: (a) a microperforated membrane based on a hyaluronic acid derivative on which keratinocytes have been seeded and cultured; (b) an underlying non-woven tissue based on a hyaluronic acid derivative wherein fibroblasts have been seeded and left to proliferate. The artificial human skin may be used in medical, surgical, diagnostic and controlled release drug delivery applications. The artificial human skin may be safely frozen to -80 DEG  C. or stored in liquid nitrogen in order to have a skin tissue bank.
Patent PT-885002-E (PT)
Title: Materials and methods for enhancing cellular internalization
Inventor: LANGER ROBERT S
IPC: A61K38/00
Filed: 1997-03-03
Abstract: Compositions and methods for delivering agents across cell membranes are disclosed. The compositions include an agent to be delivered, a viscous material, such as a hydrogel, lipogel or viscous sol, and, optionally, a carrier that includes a ligand that binds to or interacts with cell surface receptors. The agent to be delivered binds to or otherwise interacts with cell surface receptors, is attached, either covalently or ionically to a molecule that binds to or interacts with a cell surface receptor, or is associated with the carrier. Agents to be delivered include bioactive compounds and diagnostic agents. The compositions have an apparent viscosity roughly equal to the viscosity of the cytosol in the cell to which the agent is to be delivered. The rate of cellular internalization is higher when the viscosity of the viscous material and that of the cytosol in the cell are approximately the same, relative to when they are not the same. The compositions enhance cellular entry of bioactive agents and diagnostic materials when administered vaginally, nasally, rectally ocularly, orally, or to the respiratory or pulmonary system.
Patent PT-954333-E (PT)
Inventor: BROWNING JEFFREY
IPC: A61P31/18
Filed: 1997-10-24
Abstract: Compositions and methods comprising "lymphotoxin- beta  receptor blocking agents" which block lymphotoxin-ss receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
Patent PT-923301-E (PT)
Inventor: ERICKSON LINDA J
IPC: A23L9/20
Filed: 1997-08-01
Abstract: A powdered creamer which made up of agglomerated creamer particles. The creamer particles are each made up of a sweetener, a water-dispersible or water-soluble protein and an edible oil having a bland flavor and a melting point below 10° C. The powdered creamer is soluble in cold water.
Patent PT-971689-E (PT)
Inventor: KNUBEL GEORG
IPC: A61Q19/00
Filed: 1998-03-30
Abstract: Aqueous products which contain as active care principles a mixture of (a) sulphation and/or sulphonation products of saturated and/or unsaturated carboxylic and/or hydroxycarboxylic acids; and (b) fatty alcohols and/or acids, are characterised by their special gentleness and excellent skin and hair care effect.
Patent PT-1109727-E (PT)
Inventor: LECLERC PASCAL
IPC: B65D39/00
Filed: 1999-09-07
Abstract: The invention concerns a device for sealing a bottle containing a sparkling wine and includes a stopper, particularly made of cork or a synthetic material, capable of being inserted in the neck of the bottle, maintained thereon by a wire cap, and run through in the axial direction, by a conduit having first and second ends capable of communicating respectively with the bottle's internal volume and external volume. The second end is closed by a retractable closer. The device is characterized in that the stopper is axially run through by an orifice designed to receive the conduit and having an adjusted and tight cross-section relative to the conduit external section, the latter being provided at its second end, with a support flange capable of resting against the stopper upper surface.
Patent SG-18691-G (SG)
Title: N-vanillyl trienamides having anti-inflammatory and anagesic activity
IPC: A61K31/16
Filed: 1991-03-16
Abstract: Trienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: <CHEM> wherein R is a straight or branched chain tri-unsaturated fatty acid amide having from 14 to 24 carbon atoms exhibit anti-inflammatory and analgesic activity when administered to humans and lower animals.
Patent SG-35195-G (SG)
Title: Apparatus for the metered supply of powder to a powder processing unit
Inventor: KELLER SILVANO
IPC: G01G13/24
Filed: 1995-02-22
Abstract: The apparatus comprises a volumetrically working metering unit (1) and a weighing device (12, 13) which together allow a gravimetric powder metering. The metering unit (1) has a rotating metering plate (3) of vertical axis of rotation, a driving part (4) arranged underneath the metering plate (3) and, above the metering plate, powder supply and extraction devices (9, 8). This metering unit (1) of predominantly vertical extent is fixed on a weighbridge (12) which rests on a plurality of weighing cells (13). The arrangement is such that the driving part (4) is located underneath the weighbridge (12), so that the centre of gravity of the entire metering unit (1) is at least approximately level with the weighbridge (12). The tendency of the metering unit (1) to oscillate can thereby be greatly reduced in comparison with a metering unit arranged completely above a weighbridge, with the result that a gravimetric powder metering of high accuracy and uniformity is achieved. <IMAGE>
Patent IE-880012-L (IE)
Title: Article display carton
IPC: B65D5/50
Filed: 1988-01-05
Abstract: A multiple article display carton having the end walls of the display cells spaced from the end panels of the carton. Instead of gluing the end closure flaps together the top panel is provided with three foldably connected flaps designed to provide the assembly with a force or friction fit. The first flap is folded down to become the end panel of the carton, the second flap is folded up on the other side of the first flap with the transversely extending side panel flaps therebetween, and the third flap extends from the end panel to the end cell wall to hold the end cell wall in place.
[US4705208A]
Patent IE-34973-L (IE)
Title: 3-octadecyloxypropyl - 2'- trimethylammonium ethyl¹phosphate
IPC: C07F9/09
Filed: 1971-02-26
Abstract: 1280788 3 - Octadecyloxy - propan - 1 - ol derivatives DR KARL THOMAE GmbH 19 April 1971 [27 Feb 1970] 22746/71 Headings C2C and C2P The novel compound 3-octadecyloxypropyl- 2<SP>1</SP>-trimethylammoniumethyl phosphate may be prepared by removal of bromide ions, with internal salt formation, from 3-octadecyloxypropyl-phosphate-monocholine ester bromide for example by reaction with silver acetate. The compound of the invention may be used as an immunological adjuvant in conventional pharmaceutical compositions, such as granules, tablets, capsules, syrups, emulsions, suspensions, drops and ampoules. 3 - Octadecyloxypropyl phosphate - monocholine ester bromide may be prepared by reacting 3- octadecyloxypropyl - 2<SP>1</SP> - bromoethyl phosphate with trimethylamine. 3 - Octadecyloxypropyl - 2<SP>1 </SP>- bromoethyl phosphate may be prepared by reacting 3-octadecyloxy-propan-1-ol with 2-bromoethyl phosphorodichloridate, and subsequently hydrolysing the product. 3 - Octadecyloxypropan - 1 - ol may be prepared by reacting 1,3-propanediol with octadecylsulphate or an octadecyl halide.
[GB1280788A]
Patent IE-780570-L (IE)
Title: Mono-5-substituted-thiadiazinones
IPC: C07D285/16
Filed: 1978-03-22
Abstract: Selected mono-5-substituted-3-chloro-4H-1,2,6 thiadiazin-4-ones having the general formula <IMAGE> are described which are useful for control of fungal disease in plants.
[US4097594A]
Patent IE-44792-L (IE)
Title: Heterocyclic derivatives of guanidine.
IPC: A61K31/535
Filed: 1977-03-18
Abstract: Heterocyclic guanidine derivatives of the formula I <IMAGE> in which the symbols are defined in Claim 1, and their pharmaceutically acceptable acid addition salts, are obtained by reacting a corresponding compound, possessing an alkylthio radical instead of the group -NR4R5, with an amine HNR4R5 in a lower aliphatic alcohol at reflux temperature and converting the resulting salt of the compound of the formula I into the free base and, where appropriate, preparing pharmaceutically acceptable acid addition salts from compounds obtained. The quaternary products can also be prepared. The compounds of the formula I, their salts and the quaternisation products, inhibit, for example, gastric juice secretion and lower blood sugar level. They can be used as medicaments.
[GB1573532A]
Patent FI-803357-L (FI)
Inventor: SCHELER SIEGFRIED
IPC: G03C1/52
Filed: 1980-10-27
Abstract: This invention relates to a recording material containing diazo compounds, in particular a microfilm, comprising a film base which is at least partially pervious to visible radiation, a light-sensitive layer and, on the reverse side of the film base, a filter layer which absorbs light in the long-wave ultraviolet spectral range and in the short-wave visible spectral range, wherein the filter layer is composed of a polymer which is insoluble or has been rendered insoluble by cross-linking, and of at least one yellow to orange-colored dye which is compatible with the constituents of the polymer and absorbs light in the range between about 360 nm and about 500 nm. The invention also relates to a process for the manufacture of a recording material.
Patent FI-820840-L (FI)
Inventor: CAMPBELL SIMON FRASER
IPC: C07D401/04
Filed: 1982-03-11
Abstract: Dihydropyridine anti-ischaemic and antihypertensive agents of the formula:   <IMAGE> (I)  where Y is -(CH2)2- or -(CH2)3-; R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; and R3 and R4 are each independently C1-C4 alkyl or aryl-(C1-C4 alkyl); or R3 and R4 taken together with the nitrogen atom to which they are attached represent a group of the formula: <IMAGE>  where R5 is C1-C4 alkyl, aryl, aryl-(C1-C4 alkyl), benzhydryl; 2-methoxyethyl, 2-(N,N-di[C1-C4 alkyl]amino) ethyl, or cyclopropylmethyl; their pharmaceutically acceptable acid addition salts, processes for the preparation of the compounds, and pharmaceutical compositions containing them.
Patent FI-832252-L (FI)
Inventor: JOHNSTON MICHAEL DENIS
IPC: C12N5/00
Filed: 1983-06-20
Abstract: An improvement to the process for the production of interferon by adding an inducer to lymphoblastoid cells susceptible to being induced to produce interferon is described wherein the cells are treated with an enhancing agent at, or following, induction. In a preferred aspect the cells are also pretreated, before induction, with a stimulator.
Patent FI-843928-L (FI)
Inventor: ANDERSSON BJOERN HUGO
IPC: C22C38/00
Filed: 1984-10-05
Abstract: Steel and process for its manufacture which is suitable for the production of springs, especially leafsprings for vehicles. The steel which is vacuum-treated is an ordinary low-carbon steel with 0.20 - 0.40 % C. Its composition is incidentally characterised in that the oxygen content does not exceed 0.040 % and in that boron is added to an amount of 0.002 - 0.004 % and titanium to an amount of 0.015 - 0.050 %. The addition of boron causes the hardenability to increase greatly, thus making it possible to keep the carbon content low and, in consequence, reducing the danger of destructive decarbonisation. A characteristic of the process of production consists in the fact that the steel is produced in an oxygen converter in such a manner that the nitrogen content in the ladle does not exceed 20 ppm, in that it is subsequently subjected to vacuum treatment and in that Al is added so that the amount of uncombined oxygen drops to max. 40 ppm, whereafter titanium and boron are added prior to continuous casting and rolling.
Patent FI-844780-L (FI)
Inventor: REINHARDT RUDOLF
IPC: H05K7/14
Filed: 1984-12-04
Abstract: A structural assembly for interchangeably and supportably mounting electrical components of the type having snap-action mounts includes a pair of longitudinally-extending slide rails integral with a base wall of a housing. The slide rails have snap-fastening elements situated above the base wall, and bounding therewith channels in which the snap-action mounts are lockingly received with snap-action. Longitudinal grooves are provided on outer and interior surfaces of the base wall, as well as on side and end walls of the housing for receiving additional assembly parts.
Patent FI-853664-L (FI)
Inventor: HELLGREN LARS
IPC: A61K35/48
Filed: 1985-09-24
Abstract: An erection and fertility promoting agent which contains as its active component such lipid fractions derived from Cowper's and/or Bartholin's glands as those which contract gerbil colon. The invention also relates to a method for producing the agent and to the use of the agent for preparing erection and fertility promoting compositions.
Patent IE-36595-L (IE)
Title: Pyridyl derivatives of 1-phenoxy-3-aminopropan-2-ol.
IPC: C07D213/30
Filed: 1972-07-25
Abstract: 1362168 Derivatives of 1-phenoxy-3-aminopropan-2-ol CASSELLAFARBWERKEMAINKUR AG 25 July 1972 [3 Aug 1971 29 Feb 1972] 34763/72 Heading C2C [Also in Division A5] Novel, therapeutic compounds (I) (including optical isomers, aldehyde condensation products and acid addition salts thereof) where X is the group (II) or (III) and the phenyl ring I may have up to three similar or different substituents selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkynyloxy, phenyl, halogen and the radical -NR 1 R 2 , R 1 standing for alkyl or acyl and R 2 standing for hydrogen or alkyl, are made by standard methods. The following compounds are also prepared: 1-amino-3-(o-allyloxyphenoxy)-propan-2-ol and its hydrochloride, the sodium salt of nicotinoyl vinyl alcohol, 1-(2<SP>1</SP>-methoxy-4<SP>1</SP>-allylphenoxy)-2,3- epoxypropane, 1-(#-pyridyl)-3-amino-propan-1-ol N-(nicotinoylvinyl)-benzylamine and 1-(#-pyridyl)-3-benzylamino-propan-1-ol.
[GB1362168A]