baber/WOPTO huggingface dataset:
Patent DE-60221870-T2 (DE)
Inventor: FARRERONS GALLEMI CARLES
IPC: C07D417/14
Filed: 2002-07-17
Granted: 2008-05-08
Abstract: 3-(heterocyclyl-substituted aryl)-5-substituted-isoxazole derivatives (I) are new. 3-(heterocyclyl-substituted aryl)-5-substituted-isoxazole derivatives of formula (I), their stereoisomers or mixtures, different polymorphs or mixtures, N-oxides, solvates and salts are new. [Image] X : O, S, NH, OCO, NHCO, NHCOO, NHCS, NHCONH or NHCSNH; R 4>H, 1-3C alkyl (optionally substituted by 1-3 F, Cl or Br) or Het 1>; R 1>, R 3>H or F; Het 1>C-bound 5-membered ring having 1-4 N, O or S atoms and optionally substituted by NH 2, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylamino, 1-4C alkoxycarbonyl, 1-4C alkylcarbonyl, amido, CN, NO 2, F, Cl or Br, or a 6-membered ring with 1-3 N, and optionally substituted by 1-3 F, Cl or Br; R 2>pyrrolidin-1-yl, 2-oxopyrrolidin-1-yl, 1,3,4-triazol-1-yl, tetrazol-1-yl, or pyrrol-1-yl or 1,2,4-triazol-1-yl (both 3-substituted by R 6>), or pyrazol-1-yl, imidazol-1-yl, 1,2,5-triazol-1-yl, 1,2,3-triazol-1-yl or tetrazol-1-yl (all 4-substituted by R 6>), or a group of formula (i)-(vi); Q : O, S(O) xor NR 5>; x : 0-2; R 5>-(CH 2) nCOR 7>, SO 2R 7>or a group of formula (vii)-(xii); Q 1>O or S; R 1>6>-R 1>8>COR 9>, COOR 9>, CN, NO 2or C=NR 1>0>; R 7>1-4C alkyl, 1-3C alkenyl (sic), -(CH 2) p-R' 2>, -(CH 2) m-Y-(CH 2) q-R 8>or Het 2>; n, p, q, m : 0-8; Y : O, S or NH; R' 2>R 2>excluding (ii); R 8>H, 1-3C alkyl, vinyl, allyl, ethynyl, propargyl, phenyl or an optionally fused aromatic system comprising one or more 5-6 membered rings, optionally including 1-3 O, S or N and optionally substituted by 1-3 T; T, R 1>3>-R 1>5>1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, NHCOR 9>, NHCOOR 9>, COR 9>, COOR 9>, CN, NO 2, CH=NR 1>0>, F, Cl or Br; R 9>H, 1-3C alkyl or NR 1>1>R 1>2>; R 1>1>, R 1>2>H or 1-3C alkyl; R 1>0>H, 1-3C alkyl, phenyl, benzyl, OH or 1-3C alkoxy; Het 2>a group of formula (xiii)-(xix); R 6>H, F, Cl, Br, CF 3, CN, NO 2, carbamoyl, hydroxymethyl, 1-3C alkyl, 1-3C alkoxy, 1-3C alkoxycarbonyl, 1-3C alkylcarbonyl, 1-3C alkoxy, benzyloxy-1-3C alkoxy, CONR 1>9>R 2>0>, NR 1>9>R 2>0>, 1-3C alkylamino, 1-3C alkyl-CH=NOR 2>1>, CH=NOR 21>, CH=CR 22>R 2>3>, (CH 2) sNHR 1>9>, or CH=NR 1>9>; R 1>9>, R 2>0>H, 1-3C alkyl, COR 2>4>or optionally fused aromatic system comprising one or more 5-6 membered rings, optionally including 1-3 O, S or N and optionally substituted by 1-3 T; R 2>1>H or 1-3C alkyl; R 2>2>, R 2>3>H, CN, NO 2, CONR 1>9>R 2>0>or hydroxymethyl; R 2>4>H, 1-3C alkyl or alkoxy or Het 2>; and s : 0-4. [Image] [Image] [Image] ACTIVITY : Antibacterial; Cytostatic. In tests to determine antibacterial activity, 3-[3-fluoro-4-(hydroxyacetyl)piperazin-1-yl-phenyl]-5-(isoxazol-3-yl-aminomethyl) isoxazole displayed MIC values of 4, 2 and 8 Microg/ml against Streptococcus faecalisBCM-010, Staphylococcus aureusBCM-012 and Moraxella catarrhalisBCM-015, respectively. MECHANISM OF ACTION : None given.
Patent DE-60224513-T2 (DE)
Inventor: D HUART JEAN-BAPTISTE
IPC: A23L33/105
Filed: 2002-04-10
Granted: 2008-12-24
Abstract: The fat-fixing preparation is made from the dried leaves of an edible and at least partly non-assimilable cactus, especially Opuntia Ficus Indica or Nopal, ground into a powder in which at least 70 wt.% of its particles are smaller than 100 micro m or 75 micro m in size. The powder particles are coated with a film of a gastro-resistant material that is soluble in the intestine. The cactus leaves are cut into pieces and drained in the open air prior to drying, which can also be carried out in the open air or in a static or dynamic drier at a temperature of 40-60 deg C. The powder particles are coated in a film with the aid of a solution containing cellulose acetophthalate or carboxymethyl-cellulose and a plastifier such as triacetine or polyethyleneglycol.
Patent DE-60302784-T2 (DE)
Inventor: YU LEI
IPC: A61K47/48
Filed: 2003-05-13
Granted: 2006-07-06
Abstract: The present invention provides a controllably degradable cationic polymer for delivery of biomolecules (nucleic acids, peptides, etc.), drugs, molecules used in medical imaging applications, sensitizing agents used in cancer treatments, and molecules used in tissue engineering. The present invention also provides a method for synthesizing the polymer according to the present invention.
Patent DE-60304061-T2 (DE)
Inventor: MULLER DETLEF
IPC: B61F5/30
Filed: 2003-12-12
Granted: 2006-12-07
Abstract: A wheel set guidance assembly is provided for suspending a wheel set bearing ( 10 ) of a wheel set ( 20 ) to a bogie frame ( 30 ), comprising separate vertical ( 50 ), lateral ( 70 ) and longitudinal ( 40 ) guidance elements for independent guidance of the movement of the wheel set in vertical, lateral and longitudinal directions wherein the stiffness of the guidance elements can be selected independently of each other.
Patent DE-60304503-T2 (DE)
Inventor: YONG WANG YU
IPC: F16H55/30
Filed: 2003-03-21
Granted: 2006-12-21
Abstract: An improved tooth profile for a roller chain sprocket enables noise reduction from impact and polygonal action during the meshing process. The profile of the engaging flank consists of three portions which are the seating, impact and distal portions all three of which are arcs with well-defined radii and arc centres. The profile of the disengaging flank is determined in accordance to a modified form of the JIS standard in which the sprocket pitch is smaller than the roller chain pitch. The impact point is located at the tangent point, thus permitting a gradual change of the roller velocity, thereby lessening the impact level and the effects of polygonal action. <IMAGE>
Patent DE-60312720-T2 (DE)
Inventor: CORNWELL JAMES P
IPC: F04B49/03
Filed: 2003-07-10
Granted: 2007-12-06
Abstract: A check valve with an elongated body and a hole extending from an inlet end to an outlet end. A piston assembly is mounted within the body and can include a piston, a check valve seal and a piston spring. The piston spring biases the piston to a first piston location preventing air from flowing from the inlet toward the outlet end. The check valve seal can be positioned on the piston assembly to seal against either a check valve seat or the inside diameter of the hole to restrict air flow when the piston is in the first piston location. Movement of the piston to a downstream piston location can remove the check valve seal from the check valve seat and/or from the inside diameter of the hole, allowing air to flow from the inlet end toward to outlet end.
Patent DE-60317143-T2 (DE)
Inventor: AKAHANE FUJIO
IPC: B41J2/045
Filed: 2003-08-25
Granted: 2008-08-07
Abstract: A chamber formation plate (30) has a first face formed with a plurality of recesses (33) arranged in a first direction at a fixed pitch such that each of the recesses is communicated with, via a through hole (34), a second face which is an opposite face of the first face. The chamber formation plate is comprised of nickel. A sealing plate (32) is joined to the first face of the chamber formation plate so as to seal the recesses to form a plurality of pressure generating chambers. A metallic nozzle plate (31) is formed with a plurality of nozzles, and joined to the second face of the chamber formation plate such that each of the nozzles is communicated with associated one of the pressure generating chamber via the through hole. A ratio of a grain size of a crystal of the nickel with respect to a thickness of a partition wall defined between each adjacent ones of the recesses is 60% or less. <IMAGE> <IMAGE> <IMAGE>
Patent DE-60317232-T2 (DE)
Inventor: BHAGWAGAR DORAB EDUL
IPC: H01C7/02
Filed: 2003-09-08
Granted: 2008-08-07
Abstract: A heat softening thermally conductive composition comprises: a matrix comprising a silicone resin, and a thermally conductive filler. The composition can be used as a thermal interface material in electronic devices. The composition is formulated to have any desired softening temperature.
Patent DE-60317429-T2 (DE)
Inventor: SAIGO SATORU
IPC: H04W4/12
Filed: 2003-09-18
Granted: 2008-09-18
Abstract: A relay device (20) is disclosed, which can enable push type services suited to a network. The relay device (20) includes a connection detection section (201) that detects a mobile device (30) that is in a state in which the mobile device (30) can transmit/receive information through a mobile communication network (1), and a notification transmission section (202) for transmitting a result of the detection to a mail server (10) that transmits mail information to the mobile device (30). <IMAGE>
Patent DE-60319090-T2 (DE)
Inventor: CAVAGLIA GIULIANO
IPC: B01J19/28
Filed: 2003-07-03
Granted: 2014-04-10
Abstract: A process for the solid phase continuous polymerization of polyester in order to achieve a molecular weight increase, measurable by the intrinsic viscosity IV increase of the polyester, wherein the use of at least a reactor (15) is provided, the reactor (15) being cylindrical, rotary around its own central axis (S), substantially horizontal, slightly inclined so as to produce the polymerization of the polyester granules passing through the reactor by gravity thanks to the inclination and the rotation of the reactor (15), inside the reactor there being produced a purge gas flow having the same or the opposite direction with respect to the flow of the polyester granules.
Patent DE-68913771-T2 (DE)
Inventor: BRIAN SEED DR
IPC: A61K39/21
Filed: 1989-01-20
Granted: 1994-08-18
Abstract: Fusion proteins of immunoglobulins of the IgM, IgG1 or IgG3 class, wherein the variable region of the light or heavy chain has been replaced with CD4 or fragments thereof capable of binding to gp120 or immunoglobulin-like molecules comprising such fusion proteins together with an immunoglobulin light or heavy chain can be administered to an animal suffering from HIV or SIV infection. They also are useful in assays for HIV or SIV comprising contacting a sample suspected of containing HIV or SIV gp120 with the immunoglobulin-like molecule or fusion protein, and detecting whether a complex is formed.
Patent DE-68914621-T2 (DE)
Inventor: DORSCHEID MICHAEL
IPC: C13K13/00
Filed: 1989-12-14
Granted: 1994-07-21
Abstract: For the manufacture of lactulose, an alkaline aqueous solution of lactose and borax is prepared and heated at a temperature above 80 DEG C. The lactulose is separated from the resulting conversion products. Apart from the borox, no alkalising material is added to the solution. The conversion is carried out at pH 8.3. In order to maintain the sodium ions in the production cycle, the borox may be manufactured in an aqueous solution of boric acid and already simultaneously with the lactose, while the sodium ions are transferred from the solution of the conversion products in the solution of the boric acid by electrodialysis. Alternatively the sodium ions may also be removed from the solution of the conversion products as readily as possible by means of a weakly acid ion exchanger and only thereafter by means of a more strongly acid ion exchanger. The weakly acid ion exchanger is regenerated with boric acid so that borax is formed again.
Patent DE-68919113-T2 (DE)
Inventor: FOSTER BRYAN D
IPC: C04B35/565
Filed: 1989-04-25
Granted: 1995-03-09
Abstract: Components for semiconductor diffusion furnaces are constructed of a high purity impervious silicon carbide or silicon nitride matrix deposited on a pre-shaped fibrous matrix of silicon carbide, carbon, or carbon coated silicon carbide. The high purity of the matrix prevents undesired gaseous components from contaminating the atmosphere of the furnace, and the fibrous re-enforcement provides strength combined with light weight.
Patent DE-68926454-T2 (DE)
Inventor: OSTHER KURT
IPC: C07K14/155
Filed: 1989-07-06
Granted: 1997-01-09
Abstract: Monoclonal and polyclonal antibodies specific towards gp 48, having a molecular weight ranging from 46 kDa to 53 kDa. The gp 48 antibodies bind to the CD4 receptors on T4 lymphocytes, inhibiting if not neutralizing the HIV-1 virus from reacting therewith. Anti-gp 48 can be used for treating and diagnosing AIDS and related diseases.
Patent DE-68928039-T2 (DE)
Inventor: AOKI KAZUO
IPC: G03G9/10
Filed: 1989-09-06
Granted: 1997-12-11
Abstract: A composition for developing electrostatic latent images in electrographic printing or copying machinery is provided in which a toner component is blended with 10 to 40% by weight of a carrier. The toner component includes magnetic toner particles each having magnetic powder bound in a resin, and magnetic particles in admixture with the magnetic toner particles, preferably as an external additive in an amount of 0.1 to 10% by weight.
Patent DE-69001834-T2 (DE)
Inventor: BRUININK PETER
IPC: B29C35/02
Filed: 1990-02-23
Granted: 1994-01-27
Abstract: An improved process for preparing articles containing polyalkene fibres with a modulus of at least 60 GPa and a tensile strength of at least 2 GPa and a thermoplastic matrix consists in preheating the fibres and the matrix polymer to a temperature above the melting point or softening point of the matrix polymer and below the melting point of the fibres and subsequently effecting the moulding step using a device the temperature of which is below the melting point or softening point of the matrix polymer.
Patent DE-69003074-T2 (DE)
Inventor: DAY JOHN PAUL
IPC: C04B38/00
Filed: 1990-10-04
Granted: 1994-02-03
Abstract: Porous sintered ceramic material having bulk analytical composition, by weight, of 74-79% alumina and the balance being silica optionally with other oxide and.or impurities, and having a phase composition, by weight, of 50-75% mullite, 23-45% corundum, 0-6% cristobalite and the balance being substantially 2-10% amorphous alumina-silica based phase. Honeycomb structure, molten metal filter and catalytic converter made from the metal.
Patent DE-69015775-T2 (DE)
Inventor: HIGHAM PAUL A
IPC: C08B37/00
Filed: 1990-10-24
Granted: 1995-05-11
Abstract: The invention comprises polymer compositions containing cross-linked biodegradable derivatives of chitin for use in preventing adhesion between body tissues.
Patent DE-69019500-T2 (DE)
Inventor: BOURGIN ALAIN
IPC: F01P11/16
Filed: 1990-09-07
Granted: 1996-02-15
Abstract: PCT No. PCT/FR90/00596 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Sep. 7, 1990 PCT Pub. No. WO91/03633 PCT Pub. Date Mar. 21, 1991.A safety device for controlling circulation of a cooling fluid of an engine includes a valve seat, a poppet movable toward and away from the valve seat, and a temperature sensing device including a movable element for controlling the movement of the poppet toward and away from the valve seat. A eutectic solder element connects the poppet to the movable element and melts at a predetermined safety temperature. A first spring engages and urges the movable element and hence the poppet toward an engagement with the valve seat. A second spring engages and urges the poppet away from the valve seat opposite to the first spring. Thus, if the cooling fluid reaches the safety temperature and the solder element melts, the second spring moves the poppet away from the valve seat and allows the cooling fluid through the valve seat. Preferably, the movable element includes an enlarged portion, the valve seat includes a retention member extending therefrom, the first spring is compressed between the retention member and the enlarged portion, and the solder element directly connects the poppet to the enlarged portion. The poppet also preferably includes a central opening in which the enlarged portion and the first spring are partially received and movable through when the solder material melts. Further, the valve seat also includes a second retention member, and the second spring passes about the movable element and is compressed between the enlarged portion and the second retention member.
Patent DE-69021733-T2 (DE)
Inventor: KOTZIN MICHAEL D
IPC: H04B7/26
Filed: 1990-12-11
Granted: 1996-04-11
Abstract: A method characterized by distributing channel coding on either side of a limited capacity communication path (102) by partially channel coding (400) a signal at a first processing point (100) and communicating the partially coded signal over the communication path (102) to a second processing point (105). The partially coded signal is characterized by at least some but not all of the necessary coded bits. The channel coding algorithm is completed at the second processing point (105) using the communicated partially coded signal (401) thereby increasing throughput over the limited capacity path (102) while minimizing added delays. <IMAGE>
Patent DE-69023367-T2 (DE)
Inventor: BOSLEY RODNEY WAYNE
IPC: G01S7/521
Filed: 1990-02-27
Granted: 1996-04-04
Abstract: An echogenic medical devices adapted to be inserted into a patient, comprises an elongated member (123, 901, 1003) including a material (127, 1002) having an acoustic impedance different from that of the surrounding medium. For enhancing an image produced in response to a sonic beam produced from imaging equipment, the medium includes biological tissue or fluids surrounding the member when inserted into a passageway of the patient. The elongated member (901) also provides an interface (903) including the outside surface of the member and a plurality of partially spherical indentations (905). Alternatively, generally spherical particles (1002) are attached to the surface of the member (1003) for producing the image in response to the sonic beam. Materials such as stainless steel, plastic, and glass are utilized in the manufacture of the medical device. The device may also include an echogenic body member including a composite material echogenically imageable in the patient. The composite material includes a matrix material with discrete sound reflective particles made from a material different from the matrix material and embedded therein. Several sound reflective particles are disclosed, one type of particle being a glass microsphere about 5 microns in diameter. The matrix material (125) may be a plastic, and may be formed or extruded into devices such as catheters or other medical devices. The composite material may include different quantities of sound reflective particles by percent volume. Furthermore, a radiopaque material may be included in the composite material so the medical device is both ultrasonically imageable and radiographically imageable.
Patent DE-69023940-T2 (DE)
Inventor: CRAWLEY GRAHAM CHARLES
IPC: C07D217/16
Filed: 1990-02-22
Granted: 1996-04-25
Abstract: The invention concerns a heterocyclic cycloalkane of the formula I   <CHEM> wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;  X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R<1> is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R<2> and R<3> together form a (3-6C)alkylene group which, together with the carbon atom to which R<2> and R<3> are attached, defines a ring having 4 to 7 ring atoms, and which ring may bear one or two substituents;  or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
Patent DE-69029016-T2 (DE)
Inventor: ULLMAN EDWIN F
IPC: G01N33/543
Filed: 1990-08-02
Granted: 1997-03-13
Abstract: A method for carrying out an immunoassay for an analyte in which a sample suspected of containing an analyte and reagents useful for detecting the analyte of interest are combined in an aqueous medium, wherein one of the reagents includes a support and one includes a labell the improvement comprising employing as the reagents a first and second conjugate, each comprised of a specific binding pair (sbp) member bound to a small molecule wherein the small molecules of each conjugate are different.
Patent DE-69034035-T2 (DE)
Inventor: LABRIE FERNAND
IPC: C07J17/00
Filed: 1990-07-05
Granted: 2004-01-22
Abstract: A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione ( DELTA 4-dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.
Patent DE-69103620-T2 (DE)
Inventor: NICHOLS DWIGHT ELLIS
IPC: B65D1/12
Filed: 1991-10-23
Granted: 1995-04-20
Abstract: A container (10) for retaining bulk liquid materials is provided having an outer drum (12) forming an enclosed cavity bounded by a base portion (14), upright walls (16) and a top wall (18) including at least one port (20). A liner (26) is disposed within the cavity of the outer drum (12) and is fixably secured to a first bung (32) removably engaged with the port (20). The first bung (32) has a central opening (39) enabling access to the interior of the liner (26) for filling and discharge purposes. When filled with a bulk liquid material, the liner (26) conforms in shape to the shape of the enclosed cavity of the drum (12). The first bung opening (39) is sealed by a second bung member (46) in engagement with the first bung member (32). Upon the emptying of the bulk materials from the drum (12), the liner (28), being thin walled, substantially fully collapses. The first bung member (32) may then be disengaged from the port and the liner (26), in its collapsed state, removed through the port in the top wall (18) of the drum (12). Thus, an easily removable liner is provided which eliminates the necessity of cleaning the drum prior to subsequent use. <IMAGE>
Patent DE-69110150-T2 (DE)
Inventor: OKADA HIROAKI
IPC: A61K47/44
Filed: 1991-02-11
Granted: 1996-01-25
Abstract: This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, the molar composition ratio of lactic acid/glycolic acid being 80/20 to 100/0, subjecting said water-in oil emulsion to microencapsulation.
Patent DE-69118327-T2 (DE)
Inventor: DAY JOHN I E
IPC: A61K9/00
Filed: 1991-11-13
Granted: 1996-08-29
Abstract: The invention discloses a topical antipenetrant formulation of niclosamide. The preferred formulation contains about one percent by weight niclosamide, 40 to 55 percent by weight of propylene glycol and about 20 to 30 percent by weight of 95% ethanol, 20 to 25% by weight polyethylene glycol 400 and from about 0.1 to 10% by weight water. This formulation provides an effective barrier on the skin, preventing the penetration of Schistosoma cercariae, the infective stage of the parasite life cycle.