baber/WOPTO huggingface dataset:
Patent NO-983509-D0 (NO)
Inventor: KLAR ULRICH
IPC: A61K31/44
Filed: 1998-07-30
Abstract: PCT No. PCT/EP97/00440 Sec. 371 Date Jul. 30, 1998 Sec. 102(e) Date Jul. 30, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/28156 PCT Pub. Date Aug. 7, 1997The invention relates to pharmacologically active compounds that have the ability to influence the polymerisation and depolymerisation of tubulin. A range of natural mitosis toxins are used as anti-tumor agents or are in the process of being clinically tested. There are various classes of such mitosis toxins that either demonstrate their cytotoxic action by inhibiting the polymerisation of microtubules in the spindle system (for example, Vinca alkaloids, colchicine) or achieve their cytotoxic action by a GTP-independent increase in the polymerisation of the tubulin and by preventing the depolymerisation of microtubules (for example, taxol, taxoters). Owing to their physico-chemical properties, hitherto not understood, and as a result of the characteristics of neoplastic cells, mitosis toxins have a certain selectivity for tumor cells, but there still remains a not inconsiderable cytotoxicity towards non-transformed cells. The search for more selective compounds that are easier to manufacture and-like the taxane class of substances-are able to inhibit the depolymerisation of microtubules, had, surprisingly, led to the discovery of borneol esters, as described in P 4416374.6 and 19513040.5. Structural modifications in that class of compounds have revealed a considerable potential for optimisation in respect of the action on microtubules. Outstanding results have been obtained, inter alia, by formal esterification of those broneols with an acid of the Sk-H type. By synthesising the taxol derivatives described herein, in which the isoserine chain of the taxol has been replaced by Sk, the intention was to study whether it is also possible in that class of substances to achieve an improved stabilisation of microtubules, compared with taxol.
Patent NO-992286-D0 (NO)
Inventor: MATKOVICH VLADO I
IPC: A61M1/36
Filed: 1999-05-11
Abstract: A biological fluid processing system (10) for the processing of biological fluid (such as blood) is disclosed. The biological fluid processing system (10) separates gases from the system to improve storage life, safety, and the quality of the processed biological fluid. The biological fluid processing system (10) increases the yield of the processed biological fluid by allowing recovery of biological fluid trapped in various elements of the system. A typical biological fluid processing system (10) includes a collection bag (11) with conduits (12, 15) connecting it to a second container (17) for receiving biological fluid. A functional biomedical device (14) may be included. A gas inlet (13) allows gas to be introduced into the system to recover the biological fluid trapped in the system. A gas outlet (16) allows gas to be purged from the system. <IMAGE>
Patent NO-994760-D0 (NO)
Inventor: CRANE THOMAS R
IPC: A61K39/39
Filed: 1999-09-30
Abstract: An aqueous adjuvant composition comprising an attenuated lipid A derivative and a surfactant or surfactants enhances the immunological response in a warm blooded animal to a protein antigen. Attenuated lipid A derivatives useful according to the subject invention include monophosphoryl lipid A and 3-O-deacylated monophosphoryl lipid A. A surfactant or mixtures of surfactants are dissolved in a solvant. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine is a preferred surfactant. The dissolved surfactant is added to an attenuated lipid A derivative to obtain a mixture. The molar ratio of attenuated lipid A derivative to surfactant in the mixture is about 4:1. The solvent is evaporated and water is added to the resulting film. The suspension is sonicated in a 60  DEG C water bath until it becomes clear. Animals administered the adjuvant formulation exhibited increased antibody responses to a given antigen as well as displayed enhanced lymphocyte proliferative and cytotoxic T-lymphocyte responses. Intranasal administration of the aqueous adjuvant composition and an antigen stimulates the production of serum and mucosal secreted IgA.
Patent GB-0116819-D0 (GB)
Title: Zinc and zinc alloy electroplating additives and electroplating methods
IPC: C25D3/56
Filed: 2001-07-10
Abstract: An additive for an alkaline zinc or zinc alloy electroplating bath medium, the additive comprising a random co-polymer comprising the reaction product of: (i) one or more di-tertiary amines including an amide or thioamide functional group, and (ii) optionally, one or more saturated second di-tertiary amines and/or one or more second di-tertiary amines including an unsaturated moiety, with (iii) one or more saturated or unsaturated linking agents capable of reacting with said di-tertiary amines (i) and (ii), provided that, where all the linking agents are saturated, an unsaturated di-tertiary amine must he present. Preferably, the polymer has the general formula n(2x+2y+zE<SUB>p</SUB>)j-.
Patent GB-0209692-D0 (GB)
Title: A floor tool
IPC: A47L9/06
Filed: 2002-04-27
Abstract: A floor tool for use in vacuum cleaning floor surfaces includes a sole plate for engaging with a floor surface, a supporting body for the sole plate having means such as wheels or rollers for allowing the body to ride along the floor surface and an outlet conduit for coupling to a wand of a vacuum cleaner. The outlet conduit is mounted to the support platform by a connecting arm, a first end of the connecting arm being pivotally connected to the outlet conduit about a first axis and the second end of the connecting arm being pivotally connected to the supporting body about a second axis. The first and second axes are substantially parallel to one another. Fluid flow from the sole plate can be carried by a flexible hose or by the connecting arm itself.
Patent GB-0404763-D0 (GB)
Title: Improvements relating to respiratory aids
IPC: A61M16/04
Filed: 2004-03-03
Abstract: A respiratory aid (10) is disclosed for maintaining the passage of air through the upper airway of a patient. The respiratory aid (10) comprises a tubular airway (12) having a first end (14) adapted, in use, to be retained between a patient's teeth and a second end (17) extending, in use, into the patient's oropharynx. A portion of the first end (14) of the tubular airway (12) is coated with an elastomeric material, thereby reducing the likelihood of injury to the patient during use. <IMAGE>
Patent GB-0422051-D0 (GB)
Title: Breakwater wave energy converter
IPC: E02B9/08
Filed: 2004-10-05
Abstract: A device for the absorption of wave energy comprises at least one hollow block 1, with a wave-receiving surface and an opposing parallel surface, supported on a slope. At least one water-receiving tubular member 3 is held within each hollow block 1. The movement of water entering flexible tube 3 forces the air 8 above the water into an air chamber 5. The compressed air then drives turbine (9) for generating electricity. Also disclosed is a method for the absorption of wave energy comprising receiving water into a tubular member, forcing air into an air chamber, where the air drives at least one turbine.
Patent GB-0606677-D0 (GB)
Title: Door closer
Filed: 2006-04-03
Abstract: A door closer comprising: (a) a housing for fitting into a door, the housing having a mounting plate with an opening adjacent to a central bore of the housing; (b) a tension member extending longitudinally within the central bore of the housing and extending outwardly of the housing through the opening to define an end thereof for fitting to a door frame; (c) a movable body within the housing and adapted for longitudinal movement within the central bore, the movable body being connected to the tension member; (d) a spring within the housing and biasing the movable body in a first direction away from the mounting plate so as to urge the tension member inwardly of the housing in a door closing motion; and (e) a hydraulic damping assembly for damping the longitudinal movement of the movable body at least in the first direction, the hydraulic damping assembly being disposed within the central bore of the housing, wherein the hydraulic damping assembly comprises a piston, coupled to the housing by a piston shaft, and slidable in a fluid-filled chamber within the movable body, the piston divides the chamber into two compartments and the piston permits restricted movement of the fluid from one compartment to the other when the movable body is moved relative to the piston, and an accumulator comprising a compressible foam body disposed in the fluid-filled chamber so as to be compressible by the piston when the movable body has been moved by movement of the tension member out of the housing, the compressible foam body comprising an elongate body having a channel in an outer circumferential surface thereof extending along the length of the elongate body. A fitting tool for the door closer is also provided.
Patent GB-0621458-D0 (GB)
Title: System and method for routing messages
IPC: H04L29/06
Filed: 2005-04-25
Abstract: A hub-and-spoke communication arrangement is provided, in which the "hub" includes a server computer system. The "spokes" are other computers that act as message originators and/or destinations. All internal-to-external messages, and vice versa, are routed through the server computer system to reduce the number of proprietary connections needed between the internal and external entities. In addition, the server computer system provides protocol conversion, message payload conversion, encryption conversion, message broadcast, and/or message archival functionality, so that the "spoke" computers need not be concerned with providing such functionality on their own.
Patent GB-0716146-D0 (GB)
Title: Improvements relating to packaging
Filed: 2007-08-17
Abstract: A child-resistant package includes a support for supporting hazardous material in use; a structure for selectively blocking access to hazardous material supported by the support, with the support being movable between a secured position in which access to the hazardous material is blocked and an access position in which the hazardous material is accessibly clear of the structure; at least one latch member movable between an engaged state and a disengaged state in which the support is allowed to move out of the secured position toward the access position; and a tab member movable with respect to the structure in a second direction different to the first direction, the tab member being coupled to the support to effect movement of the support out of the secured position in the first direction when the latch member is in the disengaged state.
Patent GB-0816482-D0 (GB)
Title: Data stream processing
Filed: 2008-09-09
Abstract: A method for outputting data streams in a communication system, the method comprising the steps of: executing an electronic game application at a user terminal, the game application being programmed to allow two or more users of the communication system to participate in the game; receiving two or more data streams at the user terminal, each data stream being generated by a user of the communications system participating in the game; applying game logic to determine the current state of the game application; and selecting one or more of the received data streams to be output from an output device of the user terminal, wherein the selection depends on the current state of the game application.
Patent GB-0906590-D0 (GB)
Title: Analogue conversion of pulse width modulated signals
Filed: 2009-04-16
Abstract: A method of converting a periodic pulse width modulated input signal into a voltage output signal wherein the input signal is in an active state for a first portion of each of successive time periods and in an inactive state for a second portion of each time period. A first and second input is supplied to an integrator circuit and a first capacitor is coupled between a first output of the integrator circuit and the first input and a second capacitor is coupled between a second output and the second input of the integrator circuit during a first time period of the pulse width modulated signal. A third capacitor is coupled between a first output of the integrator circuit and the first input and a fourth capacitor is coupled between a second output of the integrator circuit and the second input during a successive second time period of the pulse width modulated signal. Said coupled capacitors are charged during the active state of the first and second time periods and discharged during the inactive state of the first and second time periods.
Patent GB-0908123-D0 (GB)
Title: A connection assembly
Filed: 2009-05-12
Abstract: A connection assembly for connecting a pipe, rod or pole to a connector, the assembly comprising: a collet having at a first end thereof a collet head having at least one abutment and at the second end thereof a collet collar, the collet having a bore therethrough, the collet bore being dimensioned and configured to receive and fittingly engage the pipe, rod or pole, the collet head being resiliency deformable so as to impinge on the pipe, rod or pole when deformed inwardly, the collet being provided with at least one screw thread on the external surface of the collet; a collet holder having a collet holder bore therethrough, the collet holder bore being dimensioned and configured to receive the collet, the collet holder bore comprising at least one screw thread on the surface thereof which matches the thread of the collet; and optionally a collet deflector dimensioned and configured to receive an abutment of the collet; wherein in use the collet holder and collet are mutually rotatable about a collet screw thread and a collet holder screw thread to cause the collet to engage with the collet deflector, whereby the collet deflector impinges on an abutment of the collet head to deform the collet head, which thereby impinges on and grips the pipe, rod or tube. A connector for use with the connection assembly, and a kit comprising the assembly and connector, are also described.
Patent GB-0917579-D0 (GB)
Title: Fixture for supporting a workpiece
Filed: 2009-10-08
Abstract: A fixture (10) for supporting a workpiece (18) during a machining operation. The fixture comprising a base (12) provided with a channel (14) for receiving part (16) of the workpiece (18), the channel having a first wall (20) facing an opposing second wall (22). An inflatable diaphragm (24) is located on the first wall (20), and configured to engage with an engagement surface (36) on the workpiece and bias the workpiece against the second wall. The diaphragm comprises a deformable portion (26) spaced apart from the first wall of the channel, the deformable portion having ends (28,30) which provide a seal with the first wall to define a chamber (32) enclosed by the first wall and diaphragm.
Patent GB-8400889-D0 (GB)
Title: Variation sensitive trip switch
IPC: H01H35/14
Filed: 1984-01-13
Abstract: An electrical trip switch (10) for an electromechanical or electronic vehicle alarm system, said switch (10) formed of a pair of overlying cantilevered thin flat unequally weighted springs (40, 42) spaced apart one above the other and mounted for uninhibited free end movement on a support (66) secured to a mounting bracket (16). The overlying spring (40) is horizontally oriented while the underlying spring (42) is directed from its location of securement to the bracket (16) canted toward the overlying spring (40). The overlying spring (40) vibrationally reacts only to sharp jars or similar shock transmitted by way a structural part of automobile frame while the underlying spring (42) reacts only to the forward, backward or lifting motion of the automobile. Means (88) are provided to adjust the sensitivity of the trip switch means by varying the gap distance.
Patent GB-8414335-D0 (GB)
Title: Treated collagen based surgical threads
IPC: A61L17/14
Filed: 1984-06-05
Abstract: A collagen-based surgical thread is disclosed which contains absorbed therein water, a hygroscopic agent, and a nonionic surfactant in an amount sufficient to enhance the pliability of the thread, and, in many cases, the tie down performance.
Patent GB-8500831-D0 (GB)
Title: Preparing azetidinone intermediates
IPC: C07F7/18
Filed: 1985-01-14
Abstract: Compounds of formula I <IMAGE> wherein R1 and R2 is each H, halo or an organic group, R3 is H or organic group, n=1 or 2, M is a heavy mono- or divalent metal, or M2A wherein M2 is a heavy divalent metal and A is an organic or inorganic group, are prepared by treating a starting penicillin in a solvent with a salt of M1 or M2A in the presence of a base at a temperature of from -70 DEG  to 100 DEG C. The azetidinones of formula I are useful intermediates in the synthesis of  beta -lactam antibiotics, esp.penem.
Patent GB-8514677-D0 (GB)
Title: Mean-square estimation
IPC: G06F17/18
Filed: 1985-06-11
Abstract: Each word of a succession of N bit binary words have all their ones set to zero except for the most significant one. The number of zeros after the most significant one is doubled to produce a succession of 2N bit single element words which are accumulated. The accumulated value may be read and reset after a predetermined number of words to give the mean square estimate.
Patent GB-8710828-D0 (GB)
Title: Treatment of gas streams
IPC: C01B17/04
Filed: 1987-05-07
Abstract: A first hydrogen sulphide containing waste gas stream from an oil refinery is combusted in a first combustion chamber 16 using pure oxygen to support combustion. The combustion products are cooled in heat exchanger 20, and a part of the combustion products are recycled to the chamber 16 to moderate the temperature therein. The remainder of the combustion products are mixed with a second hydrogen sulphide containing waste gas stream of different composition from the first stream. A proportion of the hydrogen sulphide content of the mixed stream is combusted in combustion chamber 28 again using pure oxygen to support the combustion. The resulting sulphur dioxide reacts with residual hydrogen sulphide to form sulphur vapour.
Patent GB-8928048-D0 (GB)
Title: Combined bolt and lock mechanisms
IPC: E05C9/02
Filed: 1989-12-12
Abstract: In a bolt and lock mechanism a bolt comprising linked rails (3, 4) is moved from the inoperative position shown to its bolting position by a handle which rotates a cam (13) to turn gears (16, 40) meshed with the rail (4). Before this, a restrictor (37) on rail (4) inhibits the action of a dead lock mechanism by lying in the path of a tongue (38) on a lever (32) carrying the dead lock member (6). When the rails (3, 4) reach their bolting position, a key can move the lock member (6) to the locking position. Then the tongue (38) will be aligned with the restrictor (37) preventing unbolting of the rails until the dead lock mechanism is unlocked.
Patent GB-9016570-D0 (GB)
Title: Glasses
IPC: G02C7/10
Filed: 1990-07-27
Abstract: Flexible eye glasses comprising of a single strip of flexible elongated plastics material, the strip optionally being shaped to provide eye and nose portions. The strip in its normal conformation may be coiled into a roll so that it may be stored in a cylindrical container. When the strip is unrolled, against its natural coiled conformation it is possible to position it against the face of a person so that its end will grip the head 15. The strip of plastic material may be laminated construction having two layers, the first layer of clear acetate material which is U.V. stabilised, the second layer is a smoked material which is not U.V. stabilised. These are bonded together. Either may have designs, patterns, borders, logo, etc., printed thereon. <IMAGE>
Patent GB-9027373-D0 (GB)
Title: Optical sensing systems
IPC: G01B11/16
Filed: 1990-12-18
Abstract: In an optically-excited micromachined silicon pressure sensor comprising a resonantly vibrating beam mounted on a diaphragm, vibration of the beam is sensed optically via the same optical fibre through which the optical excitation signal is applied to the sensor. The end of the fibre and the beam are arranged to define a cavity or gap whose width varies with vibration of the beam and which behaves as a Fabry-Perot cavity: thus light from the fibre is directed onto the beam and then reflected back to the fibre, the reflected light being modulated at the frequency of vibration of the beam. In order to overcome the difficulty of setting the gap or cavity width at an optimum value for light of a given wavelength, light of two different wavelengths is used to sense the vibrations, the wavelengths being selected such that the phase difference produced by the gap for one wavelength differs from that for the other wavelength by roughly 90 DEG .
Patent GB-9107833-D0 (GB)
Title: Treatment of periodontitis
IPC: A61K8/44
Filed: 1991-04-12
Abstract: The invention relates to the prevention or reduction of periodontitis and alveolar bone loss. It has been found that by the use of a medicament that comprises a zinc-ion containing compound such as zinc citrate or zinc glycinate, alveolar bone loss can be reduced. Suitable medicaments are in the form of toothpastes and mouthrinses.
Patent GB-9121712-D0 (GB)
Title: Fuel pump
IPC: F02M43/02
Filed: 1991-10-12
Abstract: A reciprocating plunger fuel injection pump includes a plunger (17) slidable in a bore (16). A pair of axially spaced grooves (29, 30) are formed in the wall of the bore and are interconnected by a passage (32). Associated with the grooves are a pair of changeover valves (36, 37) which are each placed in one position when the pump is supplying heavy fuel to allow fuel collecting in the grooves to flow to a drain. The valves are placed in their alternative positions when light fuel is being supplied by the pump to connect one groove with a source (39) of lubricating oil and the other groove with a lubricating oil drain.
Patent GB-9309048-D0 (GB)
Title: Bottle carrier
IPC: B65D71/00
Filed: 1993-04-30
Abstract: An article carrier comprises angularly related panels including side wall panels (42, 44) and a second wall panel (46) such as a bottom or top wall panel which are foldably interconnected, article receiving and retaining structure (10) extending between a side wall panel and a second wall panel, the structure comprising an aperture (11) adapted to receive a portion of an article (A) contained within the carrier, and a flap (12, 14) struck from and hingeably connected to an edge of the aperture which flap is adapted to abut the article received in the aperture, and wherein the flap is pivotal into an operative position about its hinged connection (26, 28) to provide portions thereof which protrude both inwardly and outwardly of the carrier so that a portion (F) of the flap engages the article internally of the carrier and another portion (F1) of the flap engages the article externally of the carrier, the flap being put into its operative position by pivoting inwardly of the carrier.
Patent GB-9312351-D0 (GB)
Title: Thermal transfer printing dyesheet
IPC: B41M5/382
Filed: 1993-06-16
Abstract: PCT No. PCT/GB94/01154 Sec. 371 Date Apr. 2, 1996 Sec. 102(e) Date Apr. 2, 1996 PCT Filed May 27, 1994 PCT Pub. No. WO94/29116 PCT Pub. Date Dec. 22, 1994A dyesheet for thermal transfer printing comprising a thermoplastic substrate film supporting a dyecoat containing a thermal transfer dye on one surface and a heat resistant backcoat on the other, wherein the backcoat comprises the following components: a) a crosslinked polymeric binder having a thickness t and containing therein a combination of b) lubricating particles and c) load-bearing particles having an average diameter greater than t, and the haze value is less than 12%.