baber/WOPTO huggingface dataset:
Patent CR-20180422-A (CR)
Title: PÉPTIDOS Y COMBINACIÓN DE PÉPTIDOS NOVEDOSOS PARA SU USO EN INMUNOTERAPIA CONTRA DIVERSOS TUMORES (DIivisional 2017-0522)
Inventor: FRITSCHE JENS
IPC: C07K14/47
Filed: 2016-03-24
Abstract: La presente invención se relaciona con péptidos, proteínas, ácidos nucleicos y células para su uso en métodos inmunoterapéuticos. En particular, la presente invención se relaciona con inmunoterapia para el cáncer. La presente invención se relaciona además con epitopes de péptidos de células T asociados con tumores, solos o en combinación con otros péptidos asociados con tumores que pueden, por ejemplo, servir como ingredientes farmacéuticos activos de composiciones para vacunas que estimulan la respuesta inmune antitumoral o para estimular células T ex vivo y transferirlas a pacientes. Los péptidos unidos a moléculas del complejo de histocompatibilidad principal (MHC) o los péptidos como tales también pueden ser el blanco de anticuerpos, receptores de células T solubles y otras moléculas de unión.
Patent CR-20220441-A (CR)
Title: Antigen-binding molecules against alppl2 and/or alpp and uses thereof
Inventor: WAN KAH FEI
IPC: G01N33/577
Filed: 2021-02-05
Abstract: The invention relates to antigen-binding molecules that specifically binds ALPPL2 and/or ALPP but not ALPL or ALPI. It also relates to a pharmaceutical composition, an immunoconjugate and a chimeric antigen receptor comprising said antigen-binding molecules. The invention also relates to methods for reducing the expression or activity of ALPPL2 in a cancer cell and methods of treating a cancer in a subject.
Patent CR-20220648-A (CR)
Title: System and method for syringe plunger engagement with an injector
Inventor: WLODARCZYK JAROSLAW
IPC: A61M5/145
Filed: 2021-06-16
Abstract: A plunger (326) for use with a syringe includes a plunger body (332) defining a central longitudinal axis (334) and having a proximal end (336), a distal end (338), and a circumferential sidewall (339) connecting the proximal end and the distal end. The plunger further includes at least one retaining member (368) associated with and extending proximally from the plunger body. The at least one retaining member has a first end connected to the plunger body, a second end proximal to the first end and radially and resiliently deflectable relative to the first end, and at least one catch (374) on the second end. A fluid injector system includes a piston (400) having a plunger engagement mechanism configured for interacting with the at least one retaining element of the plunger to releasably engage the plunger for reciprocally driving the plunger within a barrel of the syringe.
Patent EC-SP045069-A (EC)
Title: Uso de flibanserina en el tratamiento de trastornos sexuales
IPC: A61K38/17
Filed: 2004-04-20
Abstract: La invención se refiere al uso de flibanserina para la preparación de un medicamento para el tratamiento de trastornos del deseo sexual.
Patent EC-SP045126-A (EC)
Title: INHIBIDORES DEL FACTOR Xa Y DE OTRAS PROTEASAS DE SERINA IMPLICADAS EN LA CASCADA DE LA COAGULACIÓN
Inventor: BIGGE CHRISTOPHER FRANKLIN
IPC: A61P7/02
Filed: 2004-05-28
Abstract: La presente invención proporciona compuestos de fórmula de: ver gráfico: en la que A, B, C, G y W1 tienen cualquiera de los valores definidos en la memoria descriptiva, y sales farmacéuticamente aceptables de los mismos, que son útiles para tratar trastornos trombóticos. También se describen composiciones farmacéuticas que comprenden uno o más compuestos de fórmula I, procedimientos para la preparación de compuestos de la Fórmula I e intermedios útiles para la preparación de compuestos de Fórmula I.
Patent EC-SP085195-A (EC)
Title: Un comprimido farmaceutico de dos capas que comprenden telmisartan y un diurético y la preparación de dicho comprimido
Inventor: FRIEDL THOMAS
IPC: A61K9/20
Filed: 2008-09-08
Abstract: Un comprimido farmacéutico de dos capas que comprende una primera capa formulada para la liberación inmediata del antagonista del receptor de la angiotensina II telmisartán desde una matriz para comprimido que se disuelve que contiene telmisarán en forma sustancialmente amorfa, y una segunda capa formulada para la liberación inmediata de un diurético como hidroclorotiazida desde una matriz para comprimido que se desintegra rápidamente. Se describe también un método para producir un comprimido en dos capas.
Patent EC-SP088094-A (EC)
Title: Antagonistas y agonistas de piperazin-piperidina del receptor 5-ht1a
Inventor: ASSELIN MAGDA
IPC: C07D401/14
Filed: 2008-01-10
Abstract: La presente invención se refiere a nuevos compuestos de piperazin-piperidina. Los compuestos son útiles como agentes de enlace a 5-HT1A, particularmente como agonistas y antagonistas del receptor 5-HT1A. Estos compuestos son útiles en el tratamiento de trastornos del sistema nervioso central, tales como trastornos de cognición, trastorno de ansiedad, depresión y disfunción sexual.
Patent EC-SP961701-A (EC)
Title: Metodos para mejorar la salud de los bananos
Inventor: MERCER RICHARD
IPC: A01N25/00
Filed: 1996-03-28
Abstract: La presente invención tiene por objeto un método para mejorar la salud de los bananos, y una composicion agroquímica que tiene la misma finalidad.
Patent FI-20106121-A (FI)
Inventor: YLIPERTTULA MARJO
Filed: 2010-10-27
Abstract: The present invention relates material that is useful in drug delivery compositions. The material comprises cellulose nanofibers and/or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.
Patent FI-20110105-A (FI)
Inventor: DE GODZINSKY CHRISTIAN
IPC: A61B6/14
Filed: 2011-03-21
Abstract: The invention relates to an intra-oral x-ray imaging arrangement which includes as separate structures, first, a radiation source (4) having a collimator structure (4', 40) limiting an x-ray beam for producing the beam used in imaging and for aiming it to the object to be imaged, secondly, an imaging sensor (30) arranged positionable within a patient's mouth (30), and a control system of the imaging arrangement. The collimator structure (4', 40) is implemented as a structure (40) which enables adjusting a collimator opening limited by the collimator for at least one of the following: its size, its shape, its location, its position.
Patent FR-1601256-A (FR)
Title: Weftless filament tape from filaments disposed in a matrix of flexible - plastics composition
IPC: C09J7/35
Filed: 1968-12-13
Granted: 1970-08-10
Abstract: A weftless tape comprising filaments having a flexible plastic covering from end to end, coated with a first layer of a tacky adhesive followed by a second layer of adhesive of the hot-melt type. The second layer has an adhesion softening temp. at which the plastic covering is heat-stable. The softening temp. may be 150-350 deg.F. The first layer may be an adhesive of natural or synthetic rubber type such as latex. The hot-melt adhesive may be coumarone-indene resins, alkyds, terpene resins etc. Tapes useful for masking, binding and sealing.
Patent GB-1054383-A (GB)
IPC: B21D51/46
Abstract: 1,054,383. Linings for closure shells. W. R. GRACE & CO. Sept. 21, 1964 [Sept. 19, 1963], No. 38470/64. Heading B8T. Closure sealing elements are formed by distributing a mass of resin plastisol on the inner surface of a closure shell and fluxing the plastisol by exposure to infra-red radiation. Lacquered crown shells 10 are fed by star feed wheels (not shown) where they receive a quantity of a blown plastisol 16 which is distributed over the inner surface of the shell by spinning and then fluxed by being passed under infra-red lamps 22 consisting of a tungsten filament 23 enclosed in quartz 24 with a reflector 22 and emitting radiation between 7500 and 30,000 Š. During the fluxing period of 10-14 seconds a plasticizer vapour layer 28 is formed by partial evaporation and protects the plastisol from atmospheric oxidation. After fluxing the plastisol linings are moulded to shape by unheated dies and the lined crowns transferred for storage. Several plastisol compositions based on polyvinyl chloride, zinc or calcium-zinc stearate &c. are disclosed.
Patent GB-1225353-A (GB)
IPC: F24C15/24
Filed: 1967-04-07
Abstract: 1,225,353. Moulding radiants. MORGANITE RESEARCH & DEVELOPMENT Ltd. 8 April, 1968 [7 April, 1967], No. 16030/67. Heading B5A. [Also in Division F4] A radiant element for an incandescent gas fire is formed by vacuum casting a slurry containing a major proportion of refractory ceramic fibres of an average length between 0À01 and 0À5 inch on a perforated former. The slurry may be formed of a mixture of chopped refractory ceramic fibre blanket or wool and a stiffener such as alumina, or the slurry may include a metal hydroxide which is converted to an oxide on firing. The mass when cast has a "pimpled" surface which may be rubbed down when dry to give a radiant surface with protruding fibres. A radiant may be vacuum cast on a wire grid former of 72 B.S. wire mesh and the green shape is dried at 150‹ C. and fired in air for ¢ hr. at between 1000-1200‹ C. The slurry comprises 5 parts by weight of fibre, 2 parts by weight of ball clay, and 0À1 part of boron phosphate of 1À5 parts by weight of borax as a sintering aid mixed with water in a chopper mixer.
Patent GB-1230699-A (GB)
IPC: E21C35/12
Filed: 1969-09-29
Abstract: 1,230,699. Mining apparatus. EICKHOFF MASCHINENFABRIK U. EISENGIESSEREI GEB.m.b.H. 29 Sept., 1969 [7 Oct., 1968], No. 47765/69. Heading E1F. A guide for a mining tool haulage chain comprises a rail 3 having projecting members 13 providing tubular guide channels 14 for the chain, the channels having lateral openings 15 such that the chain can pass through them when slack but can not do so unintentionally when taut. The tool may be a plough 9 or a space clearing tool associated with a drum-type cutting tool. The rail is bolted to a face conveyor 1 and is located by projections engaging recesses in the conveyor. The ends of the openings 15 may diverge and the latter may be inclined to the chain. The rail may be secured to pit props instead of the conveyor.
Patent GB-1230990-A (GB)
IPC: H01L25/03
Filed: 1967-11-03
Abstract: 1,230,990. Full wave rectifier assemblies. JOSEPH LUCAS (INDUSTRIES) Ltd. 15 Oct., 1968 [3 Nov., 1967], No. 50009/67. Heading H1K. In a full wave rectifier assembly a number of rectifiers equal to the number of phases in the supply are attached by their anodes to one terminal plate 27, while an equal number are attached by their cathodes to a terminal plate 28 spaced therefrom along the axis of mounting bolt 21. Leads extending axially from the cathodes and anodes respectively of the two sets of diodes are attached to the appropriate one of a number of phase plates, in the illustrated cases 31, 33, 34, axially spaced on one side of the terminal plates. The phase plates are split as shown so as to allow relative axial movement of the leads attached to the separated parts. In the arrangement shown the phase plates are arcuate, each subtending an angle of less than 120 degrees, and the fingers on the outer parts are cranked inwards to lie in the same plane as those on the central plate. The plates may, however, be more extensive in which event plates 31, 32 must be suitably apertured as are terminal plates 28, 29 to allow leads to pass to plate 33. The additional diodes shown on terminal plate 29 provide an auxiliary rectified supply.
Patent GB-1232761-A (GB)
IPC: B05B9/04
Filed: 1970-02-06
Abstract: 1,232,761. Paint spraying unit. J. WAGNER [trading as ING. JOSEF WAGNER]. 6 Feb., 1970 [28 Feb., 1969], No. 5812/70. Heading B2F. A paint spraying unit consists of a diaphragm pump as the delivery unit from which the paint to be sprayed is fed to a spray gun from a reservoir via connecting pipes and one or more filters, characterised in that the diaphragm pump is provided with a venting valve which is connected to the delivery pipe of the pump. As shown, the unit has a diaphragm pump 2, a reservoir 3 and a spray gun 4. To enable delivery pipes 7 and 10 to be vented when the unit is started, the pump is provided with a manually controllable venting valve 12, connected to pipe 7 by a branch pipe 11. When starting the unit, if there is a mixture of paint and air in the pipe 7, the venting valve 12 is opened by switch (47) and the mixture of paint and air flows via pipe 13 into the reservoir 3, stirring the paint in the reservoir, and the pump 2 draws paint without any difficulty. When constant delivery is obtained the valve 12 is closed, and the air present in filter 9 and pipe 10 is forced out by the paint. The pipe 10 is flexible as appropriate to individual requirements.
Patent GB-1233073-A (GB)
IPC: G03F7/20
Filed: 1968-05-29
Abstract: 1,233,073. Photographic apparatus. MULLARD Ltd. May 29, 1968, No.25719/68. Heading G2A. A method of providing a pattern of exposure in a photo-sensitive layer 11, e.g. as a step in the manufacture of optical masks, printed circuits, integrated circuits or semi-conductor devices, comprises producing light pulses through an aperture 6 in a continuously rotating disc 4, the light pulses being incident upon a pattern of apertures 22 in a mask 8 which are individually opened or closed for the entire duration of a light flash by associated Piezo-electric elements 9, the layer being moved linearly, the control signals applied to the Piezo-electric elements being time sychronized with the movements of the layer and the plate so that a desired pattern is produced by successive exposures to successive light pulses through an aperture pattern selected for each pulse. After the layer has been moved in the predetermined  direction, a motor 18 driving both the layer and the disc is stopped, e.g. under the control of a limit indicator provided on table 13, and the layer is moved transversely to the first direction, a further pattern of exposure is given with movement of the layer parallel to the first direction in the same or opposite sense. A light source and photodiode 25 co-operate with an aperture provided in a disc rotated by a rod 15 which moves the layer in the first direction and acts to compensate for overrun of the motor 18 after de-energization. The apertures are focused by a lens system 10 to a reduced size on the layer 11 which may rest on a diaphragm coupled to a source of gas pressure, the gas pressure below the diaphragm being regulated in accordance with the gas flow from a nozzle spaced by a small distance above the layer to thus compensate for variations in the distance between the lens system and the layer. The Piezoelectric elements are controlled by signals derived from a punched or magnetic tape, the rate of tape reading being controlled with the aid of a photocell and light source 24 co-operating with an aperture in the rotating plate. Alternatively, a photo-cell may scan a master copy of a pattern to be reproduced to produce control signals or a computer may be used.
Patent GB-1234639-A (GB)
IPC: C08J9/00
Filed: 1968-11-13
Abstract: 1,234,639. Extruding expandable material. DOW CHEMICAL CO. 3 Nov., 1968 [13 Nov., 1967], No. 53759/68. Heading B5A. [Also in Division C3] An extrusion process for making an expandable polymeric composition comprising a solid thermoplastic polymer having a volatile organic compound uniformly dispersed throughout, which process comprises continuously supplying devolatilized thermoplastic polymer melt, which is freshly prepared from at least 50% by weight of a monovinyl aromatic compound in a polymerization of monomers and a volatile organic compound under superatmospheric pressure at temperatures between 160 and 280 C. to a mixing and cooling zone, advancing the mixture toward an extrusion orifice or die, cooling and blending the mixture during said advancing to a uniform temperature between 90 C. and a temperature below the heat-softening temperature, extruding the mixture into a zone of atmospheric pressure or a pressure greater than the vapour pressure of the volatile organic compound, and cooling the extruded material to a rigid condition, the mixture of thermoplastic polymer and the volatile organic compound being continuously extruded at a rate equivalent to that at which the devolatilized polymer melt and volatile organic compound are supplied.
Patent GB-1238457-A (GB)
IPC: G01M1/12
Filed: 1967-12-05
Abstract: 1,238,457. Determining unbalance. ROTAX Ltd. Nov.20, 1968 [Dec.5, 1967], No.55188/67. Heading G1X. Apparatus for determining the static unbalance of a rotatable device 18 comprises a vertically disposed tubular column 16 universally supported on a fixed arm 11 by means of knife edges 12, 14 disposed on axes at right angles to each other and cradles bearing on the knife edges 13, 15, the cradle 15 being secured to the column 16, a light source 20 within the column directing beams of light limited by apertured plates 21 along opposite directions on the axis of the column 16, and scales 24, 25 on which the respective light beams impinge and which by the position of the points at which the light strikes the respective scale will give an indication of any static unbalance of the device 18. The column 16 carries a bearing plate 17 for the device 18 and a counterweight 19 the position of which is adjustable longitudinally of the column to vary the sensitivity of the apparatus. The plates 21 may be replaced by lenses and the scale 25 which is used when the device 18 does not have a central aperture may be replaced by mirrors reflecting the light to a scale fixed at another point of the apparatus. A clamp mechanism 26 may be provided to prevent movement of the column 16 until required and this may include a clamping device. To improve the accuracy of the apparatus the knife edges 12, 14 may be disposed in one plane.
Patent GB-1238923-A (GB)
IPC: D04H5/08
Filed: 1968-11-25
Abstract: 1,238,923. Apparatus for non-wovens. CURLATOR CORP. 25 Nov., 1968 [18 Dec., 1967], No. 55826/68. Headings D1F and DIN. A non-woven fibre web composed of at least two different materials is formed by feeding fibres such as staple fibres by means of air streams down the ducts 22, 23 onto oppositely rotating condensers 25, 26 respectively. The fibres are formed into laps between the drums 25, 26 and plates 28, 29 respectively and doffed therefrom by rollers 31, 32, 33 and 34, 35, 36 onto lickerins 53, 54 respectively which comb fibres from the laps. Air stream from the chambers 41, 42 aid in doffing the fibres from these lickerins and convey them down the ducts 57, 58 to the oppositely rotating drums 69, 70 respectively. Material different from these fibres is simultaneously delivered between the drums 69, 70 so as to form a non-woven web which is conveyed away by the belt C. The different material may be continuous filaments such as plastic or glass fibres which are fed from rotary bobbins 73 and/or beams 74 and guided by rods 76. Some of the filaments pass straight through nozzles 77 in plate 61 and others pass through a weft laying unit 78 above 61. In another embodiment different short length fibres are fed between drums 70, 69 by means of a third lickerin intermediate 53, 54. Alternatively the "different material" may be a powdered thermoplastic continuous filaments which have been coated with a tacky substance prior to feeding between drums 69, 70.
Patent GB-1239177-A (GB)
IPC: B23D71/02
Filed: 1970-03-26
Abstract: 1,239,177. Rotary tyre rasps. KOOKABURRA RETREAD EQUIPMENT PTY. Ltd. 26 March, 1970 [1 April, 1969], No. 14802/70. Heading B4B. A rotary rasp blade for use in removing the tread from worn tyres comprises a body 1 of sheet metal having a plurality of pairs of teeth 3, the teeth of each pair e.g. 4, 5 and 6, 7 being inclined in the same direction and oppositely to the teeth of the adjacent pairs, the tips of the teeth being disposed in at least two transversely spaced rows there being at least one row of set teeth to each side of the blade, those teeth having their tips in a row each being oppositely inclined to the adjacent teeth having tips in that row. The angle between the edges of the elongated teeth may be between 5 and 10 degrees, Fig. 3 (not shown).
Patent GB-1239267-A (GB)
IPC: B25C1/18
Filed: 1968-12-07
Abstract: 1,239,267. Fastener driving tool. HILTI AG. 7 Dec., 1968, No. 58259/68. Heading B4C. A cartridge actuated fastener driving tool comprises a barrel 2 slidable in housing 1 and having a cartridge chamber 6, a cartridge firing mechanism, a piston 4, cartridges 5 mounted in a disposable plastics strip 17, and an automatic mechanism for advancing the strip to move cartridges successively to the firing position. The strip passes upwardly through a breech member 31 received within the housing and having forwardly extending side portions ending in stop surfaces 16c. When the tool is applied to a work surface, the barrel is moved rearwardly to the position shown in Fig. 3 in which position seals are formed between the chamber and strip and between the strip and the cartridge to be fired and the housing 10 and pin 7 of the firing mechanism are moved by a cocking rod 9 against springs 8a, 8b. Actuation of trigger 15 causes a lever 13 to pivot and to move detent 12 against its spring, thus releasing the firing pin 7. Movement of the barrel 2 away from the position of Fig. 3 allows a rocking lever 18 to pivot under spring bias so as to engage toothed member 18a with a notch in the strip. Return of the barrel to the firing position will cam the lever 18 to the position of Fig. 1 and thereby cause, the next adjacent cartridge to be moved into the firing position. When a cartridge is fired a shoulder 30a on the barrel engages the stop surfaces 16c so as to prevent excessive compression of the strip portion lying between the rear surface of the barrel and the facing surface of the breech member 31.
Patent GB-1256573-A (GB)
IPC: G01F1/60
Filed: 1969-08-19
Abstract: 1,256,573. Breakpoint function generators. TOKYO KEIKI CO. Ltd. 19 Aug., 1969 [20 Aug., 1968], No. 41368/69. Heading. G4G. [Also in Division G1] The output of a M.H.D. ships log detector 11 is linearized by a negative feedback circuit in which a proportion of the rectified output of an alternating current amplifier 15 is fed back via a characteristic determining diode resistance network and a Hall plate 17 subjected to. an alternating magnetic field in synchronism with an alternating current applied to the detector. In Fig. 1, the point at which each of the diodes D1 to D4 conducts is determined by the setting of potentiometers VR b1  to VR b4  and the effect produced thereby is determined by the setting of potentiometers VR a1  to VR a4 . In an alternative arrangement (Fig. 2, not shown), Zener diodes are used, the potentiometers VR b1  to. VR b4  being dispensed with.