baber/WOPTO huggingface dataset:
Patent CA-3131052-A1 (CA)
Title: Pharmaceutical composition for subcutaneous injection comprising human hyaluronidase ph20 variant and drug
Inventor: PARK SOON JAE
IPC: A61K47/68
Filed: 2020-03-24
Abstract: The present invention relates to a pharmaceutical composition comprising (a) a drug and (b) a human PH20 variant. The human PH20 variant contained in the pharmaceutical composition according to the present invention includes an amino acid substitution at one or more positions selected from the alpha helix 8 sequence (S347-C381) and a linkage region (A333-R346) between alpha helix 7 and alpha helix 8 on the wild-type human pH20 having the amino acid sequence of SEQ IS NO: 1, and is optionally cleaved at an amino acid positioned at the N-terminal or C-terminal region. In addition, the pharmaceutical composition according to the present invention may further comprise a pharmaceutically acceptable additive, particularly, a stabilizer. Due to the advantage of the human PH20 variant, the pharmaceutical composition according to the present invention can exhibit a maximum therapeutic effect of the drug used together therewith.
Patent CA-3132334-A1 (CA)
Title: Module electronique mis sous boitier et son procede de fabrication
Inventor: LALO CYRIL
IPC: G06K19/07
Filed: 2020-03-11
Abstract: La présente invention concerne un module électronique mis sous boîtier comprenant des éléments électroniques intégrés destiné à être utilisé dans des cartes à puce. La présente invention assemble une pluralité de composants électroniques sur une carte de circuits imprimés souple, conjointement avec un microcircuit intégré et une plaque de contact, dans un module. Ce module peut ensuite être intégré dans une carte en plastique, à l'aide de techniques de fraisage classiques, par un fabricant de cartes. Ce procédé met sous boîtier la pluralité de composants électroniques dans un module. La présente invention permet à une entreprise d'éviter des dépenses d'immobilisation supplémentaires requises pour un équipement spécial et permet à tous les fabricants de cartes existants de fabriquer des cartes à puce comprenant des éléments électroniques intégrés.
Patent CA-3133166-A1 (CA)
Inventor: KATO KO
IPC: C07K14/08
Filed: 2019-03-14
Abstract: An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbEPI42 (SEQ ID NO:1); nbSNS46 (SEQ ID NO:2); nbCSY65 (SEQ ID NO:3); nbHEL40 (SEQ ID NO:4); and nbSEP44 (SEQ ID NO:5). Methods for using the isolated expression enhancer are also provided.
Patent CA-3133738-A1 (CA)
Inventor: HEITELE BERND
IPC: C02F1/68
Filed: 2020-03-13
Abstract: The invention relates to a method for operating a water filter cartridge in a pipe, said water filter cartridge having a housing in the form of a pressure vessel, and an inlet and an outlet for water, characterized in that a main flow of water to which minerals are added is conducted through a main pipe inside the pressure vessel, and a dosing flow of concentrated salt solution is conducted through a dosing pipe, wherein the dosing pipe branches off from the main pipe and passes through a reservoir of constant volume and in which there is a concentrated salt solution consisting of sulphate salt, chloride salt and/or hydrogen carbonate salt, wherein the part of the dosing pipe extending from the reservoir leads into the main flow at a dosing point through a dosing opening with a constant flow cross-section, and wherein a resistance section which is situated upstream of the dosing point in the main flow is used to set the flow resistance in the main flow such that a pressure difference results between the main flow and the dosing flow and causes a volumetric flow rate of the dosing flow of salt solution which is substantially proportional to the main flow, through the dosing opening opening into the main flow.
Patent CA-3140062-A1 (CA)
Title: Apparatus and method for cryostorage and manipulation of a plurality of container units
Inventor: VAN BOKKELEN GIL BRADFORD
IPC: F25B9/14
Filed: 2020-05-11
Abstract: An apparatus for cryostorage and manipulation of a plurality of container units includes a cryochamber having a cryo-access port. The cryochamber is electrically cooled at cryogenic temperatures. A unit holder is located inside the cryochamber and is configured to hold a plurality of container units. A user access area is provided for selectively permitting access to a chosen container unit by an authenticated user who has been authenticated by the apparatus. A motive grasper is provided for selectively removing the chosen container unit from the cryochamber through the cryo-access port, and selectively placing the chosen container unit into the user access area.
Patent CA-3140155-A1 (CA)
Title: Robotic device configuration
Inventor: FOFONOFF TIMOTHY A
IPC: B25J15/00
Filed: 2020-06-25
Abstract: Robotic device configuration methods and systems. The methods described herein may involve operably positioning a robotic device with respect to a storage rack, wherein the storage rack holds at least one first coupling member configured with a first tool, and the robotic device includes a second coupling member; operably connecting the second coupling member to the first coupling member; and removing the first coupling member configured with the first tool from the storage rack.
Patent CA-3140732-A1 (CA)
Inventor: CHODOR PIOTR
IPC: A61F2/90
Filed: 2021-11-30
Abstract: A stent of the aortic valve which is self-expandable and repositionable and preferably made from nitinol, consisting of two parts: the upper part and the lower part. The lower part is a mesh (1) laid out so that it creates a kind of cylinder wall on the entire height of the element. Also other shape of the mesh is acceptable, for example partially conical, or partially resembling flattened side wall of the cylinder. The upper part of the stent consists of derived from the mesh (1) upwards and arranged at equal intervals three arms (2) the height of which is slightly larger than the height of the mesh (1), a bit less than the height of the mesh (1) or equal to its height. The stent arms (2) are shaped in such a way that they form together a kind of an oval chalice bowl, and their end, peripheral part is preferably straight and also inclined to the middle.
Patent CA-3140823-A1 (CA)
Title: Electric saw
Inventor: SARMIENTO MIGUEL ANGEL
IPC: B23D45/02
Filed: 2021-11-30
Abstract: The invention relates to an electric saw, comprising: a frame (2) mounted on a base (1), a cutting head (3) mounted on the frame by means of a rotating shaft (4) in the vertical direction and an adjustable stop (5) limiting the descent of the head and the cutting depth. The adjustable stop (5) comprises: a rod (51) mounted in a through manner, with the possibility of longitudinal sliding, in a passage (53) defined in the cutting head (3) and facing a fixed stop (21) defined in the frame (2); and a screw (54) for lateral tightening and fixing of said rod (51) inside the passage (53). The screw (54) comprises an actuation knob (55) and is threadedly mounted in a hole defined in the cutting head (3) and leading into the mounting passage (53) of the rod (51).
Patent CA-3141313-A1 (CA)
Title: Gene knockout of variant nrf2 for treatment of cancer
Inventor: KMIEC ERIC
IPC: C12N15/113
Filed: 2020-05-22
Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from a variant NRF2 gene found in a cancer cell but not in a non-cancerous cell. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from a variant NRF2 gene in the subject. Methods of treating cancer comprising administering a pharmaceutical composition comprising: a DNA sequence encoding a guide RNA that is complementary to a target domain from a variant NRF2 gene in the subject; and a nucleic acid sequence encoding a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, are also provided.
Patent CA-3143498-A1 (CA)
Title: Bacteria-engineered to elicit antigen-specific t-cells
Inventor: FISCHBACH MICHAEL A
IPC: A61K39/08
Filed: 2020-06-18
Abstract: Provided are modified microorganisms, such as live recombinant commensal bacteria, that express a heterologous antigen, and methods of using the modified microorganisms to induce an antigen-specific immune response to the heterologous antigen. The modified microorganism can be used to induce a regulatory T cell immune response to the heterologous antigen to treat an autoimmune disease in a subject in need thereof, or can be used to induce an effector T cell immune response to the heterologous antigen to treat a proliferative disease in a subject in need thereof.
Patent CA-3145336-A1 (CA)
Title: Immunogen
Inventor: CORREIA BRUNO
IPC: G16B5/00
Filed: 2020-07-01
Abstract: Polypeptides useful in the preparation of vaccine compositions against RSV are provided. Also disclosed are methods of enhancing subdominant antibody responses in a subject.
Patent CA-3145381-A1 (CA)
Inventor: HORBAL APRYLE
IPC: G06Q10/00
Filed: 2020-06-29
Abstract: In accordance with aspects of the inventive concepts, provided are a veterinary services system and method, in the form of an online platform that provide a full spectrum of veterinary services via a virtual clinic collaborative tool. The platform enables remote consultations in a seamless and secure environment between patients, owners, and veterinarians and allows for the sharing and collaboration of clinical data between all parties involved. The platform enables veterinarians to see patients/owners in any clinical setting, including a virtual care setting. Providers can collaborate in real-time, virtually using video functionality supported by the platform.
Patent CA-3145711-A1 (CA)
Title: Reconfigurable battery system for efficient charging and discharging
Inventor: TRELA JOHN A
IPC: H01M50/269
Filed: 2022-01-13
Abstract: A reconfigurable battery system is disclosed. The reconfigurable battery system comprises a reconfigurable battery cell array, a controller, and a bus switch.  The battery cell array is configured to operate in a first discharge mode, a second discharge mode, or a charge mode. The battery cell array includes a plurality of battery cells arranged as at least a first column of battery cells between a second battery terminal and a first battery terminal and a switch between each battery cell within the first column of battery cells. The bus switch is in signal communication with the battery cell array at the first battery terminal and is configured to select between electrically connecting the first battery terminal to a normal voltage bus or a high-voltage bus.
Patent CA-3148120-A1 (CA)
Title: Geographic routing mesh network
Inventor: Li wen zheng
IPC: H04W40/24
Filed: 2022-02-09
Abstract: The disclosure relates to method and system for geographic routing mesh network. The method may include determining, by a first node, a first list of nodes proximal to the first node in a mesh network. The method further includes sending, by the first node to each node on the first list of nodes, the first list of nodes proximal to the first node. The method(s) further includes receiving, by the first node in response to sending the first list of nodes, one or more second list of nodes from one or more nodes of the first list of nodes, each of the one or more second list of nodes being proximal to one of the one or more nodes of the first list of nodes and updating, by the first node in response to receiving one or more second list of nodes proximal to the one more nodes of the first list of nodes, one or more nodes of the first list of nodes.
Patent CA-3151141-A1 (CA)
Title: Policy control for multiple accesses
Inventor: QIAO WEIHUA
IPC: H04W76/15
Filed: 2020-08-24
Abstract: A wireless device sends a registration request message to an access and mobility management function (AMF) of a network. A registration accept message is received from the AMF. The registration accept message comprises an access traffic steering switch and splitting (ATSSS) capability indication of the network.
Patent CA-3156828-A1 (CA)
Title: Tricyclic kinase inhibitors and uses thereof
Inventor: GRAY NATHANAEL S
IPC: A61K31/505
Filed: 2020-10-02
Abstract: The present disclosure provides compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK) (e.g., Janus kinase 2 (JAK2)) and/or cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 11 (CDK11)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).
Patent CA-3159587-A1 (CA)
Title: Compositions comprenant une charge minerale carboxylee de maniere mecanochimique et liant de ciment et/ou d'asphalte
Inventor: SINHA APOORV
IPC: C09C3/04
Filed: 2020-11-04
Abstract: La présente invention concerne des compositions comprenant une charge minérale carboxylée de manière mécanochimique et un liant, le liant étant du ciment et/ou de l'asphalte et la charge pouvant être obtenue par carboxylation mécanochimique d'un minéral à base de silicate. L'invention concerne en outre un procédé de préparation desdites compositions. L'invention concerne également un procédé de préparation de béton à partir de ces compositions et le béton pouvant être obtenu à partir dudit procédé de préparation de béton. L'invention concerne aussi des utilisations de la charge minérale carboxylée de manière mécanochimique, par exemple en tant que charge dans de l'asphalte ou du ciment.
Patent CA-3160022-A1 (CA)
Title: Soccer trainer net
Inventor: HUTH RICHARD RAYMOND
IPC: A63B63/00
Filed: 2020-12-01
Abstract: A soccer training net includes a frame having an upper portion and a lower portion, a generally rectangular net having a bottom edge and a top edge, and a lower elastic member having a first end, a second end, and a medial section that extends between the ends. The medial section is coupled with and extends along the bottom edge of the net. Each end is coupled the lower portion of the frame. Upper coupling members extend between and are coupled with the upper portion of the frame and corners of the top edge of the net. The frame does not include a member that extends along the bottom edge of the net such that the medial section of the lower elastic member and the bottom edge of the net are suspended between the sides of the lower portion of the frame.
Patent CA-3160909-A1 (CA)
Title: Systems and methods for quantifying saved time
Inventor: GIRI NEHA
IPC: G06F40/174
Filed: 2022-05-30
Abstract: Systems and methods for quantifying saved time during data entry.
Patent CA-3163600-A1 (CA)
Inventor: HARP GARY
IPC: B01D67/00
Filed: 2020-09-21
Abstract: Organic solvent nanofiltration membranes that include at least one polymer coated expanded polyparaxylylene (ePPX) membrane are provided. A substrate/support layer may be positioned on one side of the ePPX membrane. In some embodiments, the substrate/support layer is sandwiched between ePPX membranes. Processes for manufacturing and using such organic solvent nanofiltration membranes are also provided. The organic solvent nanofiltration membranes are capable of separating and/or concentrating solutes from a solution comprising a lower molecular weight organic solvent with high permeability. The polymer coated ePPX membranes may also be resistant to chemical attack, resistant to gamma radiation, thermally stable, biocompatible, and strong.
Patent CA-3165826-A1 (CA)
Inventor: CHO DONALD
IPC: B01D39/14
Filed: 2021-01-22
Abstract: A filter element is provided that includes a plurality of individual fibers, wherein each individual fiber has a non-circular cross-section. The filter element also includes at least one flat sheet media, wherein the plurality of individual fibers are thermally bound to the at least one flat sheet media, wherein the flat sheet media is spirally wound to create a cylindrical profile.
Patent CA-3169124-A1 (CA)
Title: Coatings for roofing materials and related methods
Inventor: MERCADO RAMIL MARCELO L
IPC: E04D1/22
Filed: 2022-07-08
Abstract: Some embodiments relate to a roofmg material. The roofing material may comprise, consist of, or consist essentially of a substrate and a coating on the substrate. In some embodiments, the coating may comprise, consist of, or consist essentially of a polymer blend and at least one filler. In some embodiments, the polymer blend may comprise, consist of, or consist essentially of at least one hydrocarbon oil, at least one resin, at least one polymer, or any combination thereof.  I.n some embodiments, the at least one hydrocarbon oil, the at least one resin, the at least one polymer, or any combination thereof may be present in an amount or in amounts sufficient to result in the polymer blend or the coating having a select softening point, a select viscosity, or any combination thereof.
Patent CA-3169154-A1 (CA)
Inventor: SABIR AALIYA
IPC: A42B5/00
Filed: 2021-02-24
Abstract: A fastener system for clothing and other personal items is disclosed. The fastener system uses a combination of materials to form elements that can be adapted to different fastening applications. A first component of the system includes two members. The first member has an aperture for accommodating a T-shaped attachment member and a button. The second member has a T-shaped attachment member that fits through the aperture and rotates sideways to prevent passing backward through the aperture. The second member also has a strap for securing the attachment member against the aperture by attaching the strap to the button. A second component of the system includes a button with an enlarged head and base, and a flexible washer that fits over the head of the button. Fabric of an article to be secured may be laid over the head of the button and secured around the head of the button using the washer.
Patent CA-3169303-A1 (CA)
Inventor: SHEN XIAOKUN
IPC: A61P31/12
Filed: 2021-02-24
Abstract: Provided is application of a poly ADP ribose polymerase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of antiviral agents or in the preparation of medicines for the treatment of diseases caused by viruses, wherein the viruses are ?-coronaviruses. Also provided is application of a compound represented by formula III and/or a compound represented by formula IV or a pharmaceutically acceptable salt thereof in the preparation of antiviral agents or in the preparation of medicines for treatment of diseases caused by viruses, the viruses being HIV, HPV, EBV, IFV and/or coronaviruses. The poly ADP ribose polymerase inhibitor comprises a compound represented by formula III and/or a compound represented by formula IV or a pharmaceutically acceptable salt thereof, and can achieve a lower effective concentration for inhibiting viruses and a higher antiviral activity while ensuring low toxicity and high safety when being used in human bodies, so that in the application to the clinical treatment of diseases caused by coronaviruses, the present inhibitor can effectively inhibiting the viruses.
Patent CA-3173997-A1 (CA)
Title: Method and system for laser phase tracking for internal reflection subtraction in phase-encoded lidar
Inventor: CROUCH STEPHEN C
IPC: B60W60/00
Filed: 2019-11-12
Abstract: A system and method for optical detection in autonomous vehicles includes modulating an optical signal from a laser to generate a modulated optical signal and transmitting the modulated optical signal toward an object. The system and method include receiving, responsive to transmitting the modulated optical signal, a returned optical signal and mixing the returned optical signal with a reference optical signal associated with the optical signal from the laser to generate a mixed optical signal and detecting the mixed optical signal to generate an electrical signal. Based on the electrical signal and the modulated optical signal, a parameter of an internal reflection of the returned optical signal from one or more optical components is determined, which may be used to operate a vehicle.
Patent CA-3175492-A1 (CA)
Title: Device and method for artificial insemination
Inventor: PLESSALA KIRBY J
IPC: A61B17/43
Filed: 2017-11-30
Abstract: A medical device comprises: a shield configured to cover an orifice; an arm having a proximal end secured to the shield and a distal end configured to insert into an orifice, wherein the shield and the arm are configured to secure the medical device in place during use, wherein the medical device has a bore extending longitudinally through the arm and through the shield such that the bore has an opening at the distal end of the arm and an opening on the side of the shield opposite the arm; and an insert member secured to the shield, wherein the insert member is secured to the opposite side of the shield as the proximal end of the arm, wherein the insert member has an ammlar cavity, wherein the insert member has an external opening that provides external access to the annular cavity, and wherein the annular cavity is operable to receive a retention string.
Patent CA-3176120-A1 (CA)
Inventor: ESKILSSON TOMAS
IPC: E05D15/16
Filed: 2021-05-04
Abstract: Dans la présente invention, un battant de porte de placard coulissant est pourvu d'un raccord navette (40a) configuré pour relier le battant de porte à une navette de mécanisme de fermeture souple (60a) disposée dans un guide de porte, et la navette de mécanisme de fermeture souple (60a) comprend un raccord de battant de porte (62a) configuré pour venir en prise avec le raccord navette (40a). Ledit raccord navette (40a) peut être relié au raccord de battant de porte (62a) à n'importe laquelle d'au moins une première relation verticale mutuelle entre le battant de porte et la navette de mécanisme de fermeture souple (60a), et une seconde relation verticale mutuelle entre le battant de porte et la navette de mécanisme de fermeture souple (60a).
Patent CA-3177291-A1 (CA)
Inventor: VITI FRANCESCA
IPC: C12N15/24
Filed: 2022-05-17
Abstract: Disclosed herein polynucleotides complementary to IL-34, including IL-34 antisense oligonucleotides and IL-34 siRNAs, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing a polynucleotide complementary to IL-34, for example, an IL-34 antisense oligonucleotide or an IL-34 siRNA, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed polynucleotide to be used in treating inflammatory diseases and/or fibrosis.