baber/WOPTO huggingface dataset:
Patent PT-1427420-E (PT)
Inventor: HAN DUGAN MARGARET
IPC: A61K33/243
Filed: 2002-09-11
Abstract: Patients suffering from renal carcinoma are treated with a 4-pyridylmethyl-phthalazine anti-angiogenesis agent. Patients having different tumor types, e.g. renal cancer, are treated with a 4-pyridylmethyl-phthalazine anti-angiogenesis agent while undergoing chemotherapy.
Patent PT-1501496-E (PT)
Title: Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
Inventor: MOSHER GEROLD L
IPC: A61K47/48
Filed: 2003-04-29
Abstract: The invention relates to a clear liquid formulation comprising amiodarone, a method of preparing said formulation and its use for the treatment of cardiac disorders.
Patent PT-1449530-E (PT)
Title: Melt-extruded orally administrable opioid formulations
Inventor: OSHLACK BENJAMIN
IPC: A61K9/26
Filed: 1995-11-03
Abstract: A sustained release oral analgesic dosage form, comprising a combination of a pharmaceutical extrudate in the form of multiparticulates including 5 mg to 400 mg oxycodone or a salt thereof dispersed in a matrix and a pharmaceutical extrudate in the form of multiparticulates including a mu-antagonist dispersed in a matrix.
Patent PT-1678509-E (PT)
Title: Device for performing analyses on biological fluids and related method
Inventor: RICCI ANTONIO
IPC: B01L99/00
Filed: 2004-10-21
Abstract: A device for measuring the sedimentation rate in biological fluids, and particularly the erythrocyte sedimentation rate in blood samples. The device comprises: holders (3) for test tubes (P) containing samples of biological fluid; agitator devices (25) for agitating the test tubes; at least one detector (17, 19) for reading the levels inside the test tubes. The holders together form a continuous flexible member (1) defining a closed path along which the agitator devices and the detector are arranged.
Patent PT-1891283-E (PT)
Title: Floor panel provided with a core made of a derived timber product, a decorative layer and locking sections
Inventor: HANNIG HANS-JUERGEN
IPC: E04F15/02
Filed: 2006-06-14
Abstract: The panel has a core (2) made of a derived timber material, and a decorative layer (4) positioned on an upper side of the panel. Two pairs of side edges are provided, in which one pair has a receiving hook (9) facing a lower side of the panel and a locking hook (10). The hooks are provided with a distal side surface having a projecting interlocking unit that is attached to a receiving pocket. A distance of one third of the total thickness of the panel is provided between the interlocking unit and the upper side of the panel based on the thickness of the panel.
Patent PT-2062704-E (PT)
Title: Counter cutting die and die cutting device
Inventor: KOLLMANN JUERGEN
IPC: B26D7/20
Filed: 2007-11-22
Abstract: The plate (12) has a support surface (18) provided opposite to a stamped blank (16) and made of deformable, elastic and pressure-flexible material. The plate is designed as a hollow body (14) that is completely filled with gel-like or gaseous medium e.g. fluid such as low or high viscous oil. The support surface is made of spring steel or plastic. The hollow body is divided into two chambers (22), which are in connection with each other. The support surface supports a slotted punching plate (20). The plate (12) acts as a counter bearing. An independent claim is also included for a stamping device for stamping of flat element for production of production of packaging blanks or folding carton blanks.
Patent PT-1900364-E (PT)
Title: Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors
Inventor: PENNEY CHRISTOPHER
IPC: A61P17/02
Filed: 2002-04-18
Abstract: A compound of formula I   
wherein A and B are the same or different and are each H or R 1 CO; 
R 1  is C 7 -C 11  alkyl; and 
Y is 0 or NH; 
is useful in stimulating hematopoiesis.
Patent PT-2136795-E (PT)
Title: Amorphous drug transdermal systems, manufacturing methods, and stabilization
Inventor: TANG JIANSHENG
IPC: A61K9/70
Filed: 2008-03-11
Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
Patent PT-2185749-E (PT)
Title: Device and method for producing electrically conductive nanostructures by means of electrospinning
Inventor: GREINER ANDREAS
IPC: D01D5/00
Filed: 2008-08-19
Abstract: Apparatus and method for producing electrically conducting nanostructures by means of electrospinning, the apparatus having at least a substrate holder (1), a spinning capillary (2), connected to a reservoir (3) for a spinning liquid (4) and to an electrical voltage supply (5), an adjustable movement unit (6, 6') for moving the spinning capillary (2) and/or the substrate holder (1) relative to one another, an optical measuring device (7) for monitoring the spinning procedure at the outlet of the spinning capillary (2), and a computer unit (8) for controlling the drive of the spinning capillary (2) relative to the substrate holder (1) in accordance with the spinning procedure.
Patent PT-2368845-E (PT)
Title: Device and method for creating carbon dioxide snow
Inventor: FRERE EMILIEN
IPC: C01B32/55
Filed: 2010-03-01
Abstract: Device (1) comprises a feed line (2) for feeding of a medium stream, which at least partially comprises liquid carbon dioxide, and a relaxation nozzle (3) for relaxation of the medium stream with the formation of carbon dioxide snow. A detector (5) for measuring the dielectric constant of the medium stream flowing through the feed line is provided at the feed line, which is available with a computer unit (7) for determining the proportion of liquid carbon dioxide in the medium stream in data exchange. An independent claim is also included for producing carbon dioxide snow, comprising supplying the medium, which at least partially comprises liquid carbon dioxide into the feed line of the relaxation nozzle, continuously recording the dielectric constant directly or indirectly of the medium stream led through the feed line in the region before the relaxation nozzle, obtaining an information about the proportion of liquid carbon dioxide in the medium stream flowing through the feed line from the value for the dielectric constant in the computer unit.
Patent PT-670386-E (PT)
Inventor: SALLAIND JEAN-MARIE
IPC: D21H19/06
Filed: 1995-03-06
Abstract: The greaseproof paper, especially for wrapping (1) fatty foodstuffs, is damp resistant paper (2) as a barrier fr ft permeation. One layered surface of the paper is cladded with a layer (4) containing metal, at least in one zone. Also claimed is a mfg, process where the greaseproof paper is coated, followed by a metal layer applied to the coating.
Patent PT-767654-E (PT)
Inventor: TALWAR ANIL KUMAR
IPC: A61Q11/00
Filed: 1995-06-06
Abstract: An improved stable acidic antiseptic dentifrice composition with therapeutically effective amounts of essential oils formulated at a pH of between 3.0 and 5.5 is disclosed. Also disclosed is an improved stable acidic antiseptic and anticaries dentifrice composition with essential oils and one or more fluorine-releasing compounds, formulated at a pH of between 3.0 and 5.5.
Patent PT-770065-E (PT)
Inventor: ALEXANDER RIKKI PETER
IPC: C07C43/20
Filed: 1995-06-21
Abstract: Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (1) wherein L may be -OR; Z may be -C(R3)(R4)-C(R5)(R6)(R7); R may be an optionally substituted cycloalkyl group; R3, R6 and R7 may be hydrogen; R4 may be -(CH2)t-Ar-(L1)n-Ar'; R5 may be -(CH2)tAr; Ar may be a monocyclic or bicyclic aryl or heteroaryl group; L1 may be a divalent linking group; and Ar' is Ar or an Ar containing group. Compounds of the invention may be potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of various diseases, such as asthma, which are associated with an unwanted inflammatory response or muscular spasm.
Patent PT-774007-E (PT)
Title: Production of oligosaccharides in transgenic plants
Inventor: SMEEKENS JOSEPHUS CHRISTIANUS MARIA
IPC: A23L33/20
Filed: 1995-07-07
Abstract: The invention relates to a method for producing oligosaccharides, comprising selecting a gene which codes for an enzyme which is capable of converting sucrose into an oligosaccharide; linking the gene to suitable transcription-initiation and transcription-termination signals in order to provide an expression construct; transforming a suitable plant cell with the expression construct; regenerating a transgenic plant from the transformed plant cell; culturing the transgenic plant under conditions enabling the expression and activity of the enzyme; and isolating the oligosaccharides from the transgenic plant. The invention further relates to the product obtained by means of the method and to the use thereof, in addition to transgenic plants and parts thereof which are capable of producing oligosaccharides.
Patent PT-733357-E (PT)
Inventor: BOLTRI LUIGI
IPC: A61K8/02
Filed: 1996-03-18
Abstract: The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.
Patent PT-837662-E (PT)
Inventor: CLAUS GRONHOLZ DIPL ING
IPC: A61F13/14
Filed: 1996-06-26
Abstract: PCT No. PCT/EP96/02820 Sec. 371 Date Mar. 17, 1998 Sec. 102(e) Date Mar. 17, 1998 PCT Filed Jun. 26, 1996 PCT Pub. No. WO97/01994 PCT Pub. Date Jan. 23, 1997An insert for a bra, wherein the insert adaptable to the inner shape of the cup comprises at least one zone storing an active ingredient and delivering to the skin, and at least one breathing compensation zone, wherein the zones selectively deliver active ingredients only or act in a compensating manner, or carry out both functions simultaneously.
Patent PT-801190-E (PT)
Inventor: ETTEMA ANTONIUS MARINUS
IPC: E04H5/00
Filed: 1997-04-09
Abstract: The present invention relates to a wall comprising a first skin manufactured substantially from plate material and a second skin manufactured substantially from plate material, wherein insulating material manufactured from mineral wool is arranged between the skins, wherein the first skin is provided with noses arranged at regular distances and facing toward the inside of the wall and pointed connections are arranged between the noses and the second skin, wherein the space between the first skin and the second skin is wholly filled with insulating material. <IMAGE>
Patent PT-909068-E (PT)
Inventor: HEIJDEN XANDER VAN DER
IPC: G06Q10/00
Filed: 1997-10-13
Abstract: Method of and apparatus for point-to-point communication between a sender (SRV(m)) and a receiver (SRV(m)) by means of messages with flexible message formats (ILMF) wherein any of said messages includes:   a header with at least message definition references (MSG ID, MSG CLASS, MSG VERSION, MSG CREATOR), a sender identifier (SENDER ID) and a destination address (DESTINATION ADDRESS);   message content regarding:   number of fields (FIELD COUNT) and content of any field (FIELD(1), ...); number of objects (OBJECT COUNT) and content of any object (OBJECT(1), ...). p
Patent PT-942643-E (PT)
Title: Multileaf lettuce
Inventor: MOOR CORNELIS MARINUS
IPC: A01H5/12
Filed: 1998-07-15
Abstract: The invention relates to a new characteristic of lettuce which is referred to as multileaf characteristic and comprises the capacity to cause the formation in lettuce plants with a determined leaf morphology at the ready-to-harvest stage of significantly more leaves than in lettuce plants with the same leaf morphology which do not contain the characteristic. The term "significantly more" comprises: at least 1½ times as many as a lettuce type with a comparable leaf morphology, preferably at least twice as many, more preferably at least 2½ times as many, most preferably at least 200 leaves, at a ready-to-harvest stage and a determined head weight. The invention further provides a lettuce plant of the genus Lactuca in addition to a lettuce plant of the species Valerianella locusta L. (lamb's lettuce), both with the multileaf characteristic, seed of such lettuce plants and heads of lettuce.
Patent PT-1086096-E (PT)
Inventor: BEUME ROLF
IPC: A61P37/08
Filed: 1999-05-27
Abstract: Compounds of the formula Iin which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.
Patent SG-1684-G (SG)
Title: Organotin compounds and resins or polymers stabilized therewith
IPC: C07F7/22
Filed: 1984-01-05
Abstract: The novel organotin compounds contain:
 (a) at least one tin atom linked to one or two groups (G) chosen from hydrocarbyl groups or substituted hydrocarbyl groups, the group (G) or each group (G) being bonded to Sn through C;
 (b) at least one mercaptoalkanol residue bonded to Sn through the S atom of the said residue, the O atom of the said residue being bonded to one of:
 H, optionally substituted hydrocarbyl, the residue obtained by removal of the OH portion of one -COOH group of a polycarboxylic or hydroxypolycarboxylic acid, Al, B, P, Si or Ti or the residue of a compound of Al, B, P, Si or Ti that contains at least one group capable of displacing the H atom of an OH group bonded to a C atom, with the proviso that the moiety of any polycarboxylic acid so used is bonded to at least two mercaptoalkanol residues through an O atom of the said residues and a -CO- group of said polycarboxylic acid moiety;
 (c) up to 52% by weight of tin, and
 (d) up to 63% by weight of sulphur. 
<??>The compounds are useful stabilizers for resins or polymers, especially halogen-containing resins or polymers such as P.V.C. which can be heat stabilized therewith.
Patent IE-800083-L (IE)
Title: Bubble oxygenator
IPC: A61M1/32
Filed: 1980-01-15
Abstract: The disposable oxygenator is for use in an extracorporeal blood circuit and provides for blood from the patient to be oxygenated as it passes through the centre of a tubular sparger (22) with porous walls which supplies oxygen bubbles of the optimum size. The foaming blood is delivered to the top of the main oxygenator body where it is distributed by gravity flow downward across heat exchanger tubing (40). The heat exchanger is wound as a flat coil with all connections outside of the oxygenator body. A silicone-coated sponge (54) is located below the heat exchanger so that downwardly flowing foaming blood is defoamed as it passes through the sponge. Carbon dioxide and other gases are vented, and liquid blood gravitates into a tapered arterial reservoir (82). <IMAGE>
[GB2040175A]
Patent IE-860131-L (IE)
Title: Novel growth hormone-releasing peptides and method of¹treating mammals therewith
IPC: C07K14/60
Filed: 1986-01-16
Abstract: The present invention relates to novel growth hormone releasing peptides and method for increasing the release of growth hormone levels in mammals, as well as method for increasing milk production in dairy cows and increasing growth rates of animals, such as cattle, sheep, swine, and others. The novel peptides of this invention surprisingly are effective for releasing growth hormone levels in animals by replacing the natural amino acids in positions 1, 2, 3, 8, 9, 10, 12, 21 and 27, as well as derivatizing the N-terminal amino acid residue in human pancreatic islet tumor origin growth hormone-releasing factor.
[EP0188214A2]
Patent IE-890156-L (IE)
Title: Didehydro-vitamin d3 - derivatives
IPC: C07C401/00
Filed: 1989-01-19
Abstract: Compounds of the formula <IMAGE> I wherein R1 is hydrogen or hydroxy and R2 is hydrogen or fluorine are described. The compounds of formula I are useful as agents in the treatment of disease states characterized by metabolic calcium deficiencies. Examplary of such disease states are osteoporosis and renal osteodystrophy.
[US4804502A]
Patent IE-900554-L (IE)
Title: Dispensing device
IPC: A61K9/48
Filed: 1990-02-15
Abstract: Novel devices for the controlled release of active materials especially pharmaceuticals comprise a capsule formed from two seperable pieces at least part of the capsule walls is water permeable. The capsule contains a water sensitive material which on contact with water causes the two pieces to separate. In the preferred embodiment the devices comprise a generally cylindrical tube closed at one or both endsby a water swellable plug. The devices find particular application as oral dosage forms for use in man.
Patent IE-790614-L (IE)
Title: Isothiouronium phosphites
IPC: A01N57/14
Filed: 1979-08-08
Abstract: A composition for combatting fungal and bacterial diseases in plants is disclosed which contains, as the active ingredient, a compound of the formula: <IMAGE> in which: R1 is hydrogen or an alkyl radical containing from 1 to 6 carbon atoms, R2 is an alkyl radical containing from 1 to 18 carbon atoms, R1 and R2 can additionally form an ethylene or propylene chain which is optionally substituted by alkyls containing from 1 to 3 carbon atoms, and R3 and R4, which are identical or different, are hydrogen, an alkyl radical containing from 1 to 18 carbon atoms, a cycloalkyl radical containing from 3 to 7 carbon atoms, an alkenyl radical containing from 3 to 18 carbon atoms, the phenyl radical or the benzyl radical, in association with an inert carrier which is acceptable in agriculture.
[US4382928A]
Patent IE-36383-L (IE)
Title: Aryl guanidines
IPC: C07C279/18
Filed: 1972-05-23
Abstract: 1356470 Arylguanidines SEPERIC 23 May 1972 [2 June 1971] 18510/71 Heading C2C The invention comprises compounds of formula and their acid addition salts with pharmaceutically acceptable acids, wherein R and R<SP>1</SP> are each H or Me. These compounds are prepared by reacting with RNH 2 N-(2,6-dichlorophenyl)- S - methylisothiourea or N - (2,6 - dichlorophenyl) - N<SP>1</SP>, S - dimethylisothiourea (preferably in the form of hydroiodide). Details are also given for the preparation of N-(2,6-dichlorophenyl)-N<SP>1</SP>-methylthiourea. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which have hypotensive activity.
[GB1356470A]
Patent IE-820812-L (IE)
Title: Pharmaceutical composition
IPC: A61K9/24
Filed: 1982-04-06
Abstract: 1. A pharmaceutical composition which contains a calcium-antagonistic active compound, with or without additional active compounds, is intended for oral administration to produce a sustained action for continuous therapy and contains only the sustaining dose of active compound, bound to pharmaceutical auxiliaries, wherein the calcium-antagonistic active compound is Gallopamil or Verapamil and wherein, at the sustaining dose, the ratio of the constituents with rapid release of active compound to those with sustained release of active compound is from 1 : 0.6 to 1 : 6.
Patent IE-33848-L (IE)
Title: 3-(4)-aroylpiperidines
IPC: C07D317/20
Filed: 1969-06-16
Abstract: 1,268,909. Aroyl-piperidines. A. H. ROBINS CO. Inc. 18 June, 1969 [20 June, 1968], No. 30871/69. Heading C2C. Novel compounds of the formula where R denotes acetyl, aryl, carbamoyl, NC 1-8 alkylcarbamoyloxy, carbamoyloxy, aryloxy, aroyl, ethoxy, 4-phenyl-1-piperazinylacetyl, NC 1-8 -alkylcarbamoyl, N,N-di(C 1-8 alkyl)carbamoyl, N-arylthiocarbamoyl, N-arylcarbamoyl, carbethoxy or 2,3-dihydroxypropyl; R<SP>1</SP> denotes H, F, Cl, Br, C 1-8 alkyl, C 1-8 alkoxy or CF 3 ; Y denotes -CH 2 - and n is 0, or 1-4, and acid addition salts thereof, may be obtained by the steps of (1) reacting nipecotic acid or isonipecotic acid with a lower acyl anhydride to form a 1- lower acyl nipecotic or isonipecotic acid, (2) reacting the latter with thionyl halide to form the corresponding acid halide, (3) reacting the product with an aryl compound in the presence of an aluminium trihalide to give a 1-lower acyl- 3- or 4-aroylpiperidine, (4) hydrolysing to form a 3- or 4-aroyl piperidine, (5) reacting the product with an arylalkyl halide, aryloxyalkyl halide, aroylalkyl halide, #-hydroxyalkyl halide, 4- phenyl-1-piperazinyl acetyl chloride, C 1-8 alkyl isocyanate, N,N-di(C 1-8 alkyl) carbamoyl halide, arylisothiocyanate, arylisocyanate, ethyl chloroformate, 2,3-dihydroxypropyl halide, nitrourea, sodium cyanate or 2-bromoethyl ethyl ether; and where an #-hydroxyalkyl halide is used, (6) reacting the 1-(#-hydroxyalkyl)-4-aroylpiperidine with a C 1-8 alkyl isocyanate. 4-Aroylpiperidines may also be obtained by the steps: (1) dehydrating 1-acetyl-4-carbamoylpiperidine to 1-acetyl-4-cyanopiperidine, (2) reacting the product with an arylmagnesium halide to give a 1-acetyl-4-aroylpiperidine, (3) hydrolysing in an acidic medium to give a 4-aroyl-piperidine and reacting the latter as in (5) above. A further preparation of 4-aroyl-piperidines comprises reacting under cyclizing conditions using NaH a γ-[N-(2-haloethyl)-N-substituted]-amino butyrophenone of Formula X Intermediates are prepared by reacting ethanolamine with 2-(p-fluorophenyl)-2-(3-chloropropyl)-1,3-dioxolane to yield 2-(p-fluorophenyl)- 2 - [3 - N - (2 - hydroxyethyl)aminopropyl]- 1,3- dioxolane, reacting this with 2-(o-methoxyphenoxy) ethyl bromide to give p-fluoro-γ[N-2- hydroxyethyl - N - 2 - (o - methoxyphenoxy)- ethyl]-aminobutyrophenone which is acidified with HCl and then reacted with SOCl 2 to form pfluoro - γ - [N - (2 - chloroethyl) - N - (2 - omethoxyphenoxyethyl)amino]butyrophenone hydrochloride. Pharmaceutical compositions useful as tranquillizing agents comprise compounds of Formula I above and a pharmaceutically acceptable carrier, preferably in the form of tablets or soft gelatine capsules.
[GB1268909A]