baber/WOPTO huggingface dataset:
Patent NZ-209620-A (NZ)
Title: Insulin derivatives modified in the b30 position, processes for their preparation
Inventor: GRAU U
IPC: A61K38/00
Filed: 1984-09-21
Abstract: 1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE A medicament having a delayed action for the treatment of diabetes mellitus, comprising at least one insulin derivative of the formula I see diagramm : EP0137361,P16,F1  in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH2 and des-B30 human insulin Phe**B30 -NH2 and a pharmaceutically acceptable carrier. 1. Claims for the Contracting State : AT A process for the preparation of a medicament having a delayed action for the treatment of diabetes mellitus, which comprises bringing into a suitable dosage form at least one insulin derivative of the formula I  see diagramm : EP0137361,P17,F1  in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH, and des-B30 human insulin Phe**B30 -NH2 Phe**B30 -NH2 and a pharmaceutically acceptable carrier.
Patent NZ-212067-A (NZ)
Title: Derivatives of glycerophosphocholine and glycerophosphoethanolamine; preparation and use
Inventor: PALTAUF F
IPC: C07F9/09
Filed: 1985-05-14
Abstract: Preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine.
Patent NZ-220369-A (NZ)
Title: Two stage fluidised bed furnace
Inventor: KORENBURG J
IPC: F23J3/04
Filed: 1987-05-19
Abstract: A substantially enclosed circulating fluidised bed reactor (1) comprises a substantially upright reactor chamber (10) containing a fluidised bed (11) of granular material and a substantially upright and cylindrical cyclonic reactor vessel (20) adjacent to the chamber, the respective upper regions (16, 18) of the chamber and the vessel being connected via a conduit (14) and the respective lower regions of the chamber and the vessel being operatively connected. The vessel (20) has a cylindrically shaped exit throat (21) aligned substantially concentrically with it at its top. Operation of the reactor comprises feeding matter to be reacted into the chamber (10); supplying a first stream of pressurised air or other gas to the reactor through a plurality of openings (12) at the bottom of the chamber (10) at a sufficient velocity to fluidise the granular material and the matter in the circulating regime for reacting a minor portion of the matter in the chamber, whereby a substantial portion of the granular bed material, reaction product gases and unreacted matter are continually entrained out of the chamber and into the cyclonic reactor vessel (20) via the conduit (14); tangentially supplying a second stream of pressurised air into the vessel (20) through a plurality of openings (19) in the cylindrically shaped interior side wall of the vessel for cyclonic reaction of a major portion of the matter in the vessel, the second stream being supplied, and the vessel being constructed and operated, so as to produce a Swirl number of at least about 0.6 and a Reynolds number of at least about 18,000 within the vessel for creating a cyclone of turbulence therein having at least one internal reverse flow zone, thereby increasing the rate of combustion therein; permitting the reaction product gases generated in the reactor to exit from the reactor via the exit throat (21) while retaining substantially all of said granular material and unreacted matter within the reactor; collecting the granular bed material and any unreacted matter in the lower region of the vessel (20) and returning it to the lower region of the chamber (10) and controlling the reaction process in the reactor by controlling the flow of the first and second streams of air and by controlling the flow of granular bed material and matter to be reacted in the chamber and the vessel.
Patent NZ-234023-A (NZ)
Title: Stereoisomers of 4-(3-(ethyl(3-(propylsulphinyl) propyl)amino-2- hydroxypropoxy) benzonitrile and pharmaceutical compositions
Inventor: ALMGREN KNUT OLLE SEVED
IPC: C07C317/02
Filed: 1990-06-12
Abstract: 4-[3-[ethyl[3-((R*)-(propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy] -benzo n itrile, 4-[3-[ethyl[3-((S*)-(propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy] -benz on itrile, 4-[3-[ethyl[3-((R*)-(propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy] -benz on itrile, 4-[3-[ethyl[3-[((S*)-(propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy ]-ben zo nitrile and pharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.
Patent NZ-236276-A (NZ)
Title: Dna encoding factor viii: comprising two polypeptide chains, a 90 kda a chain polypeptide and an 80 kda c chain polypeptide
Inventor: ALMSTEDT ANNELI B
IPC: C12N15/12
Filed: 1990-11-29
Abstract: A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA segment coding for the 90 kDa chain of human factor VIII and a second DNA segment coding for the 80 kDa chain of human factor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of 4 to about 100 amino acid residues of the B domain of human factor VIII, at least 4 of said amino acid residues originating from the C terminal of said domain;     recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bond.   <IMAGE>
Patent NZ-242627-A (NZ)
Title: Managing use of licensed software; potential user requests permission before use
Inventor: WYMAN ROBERT MARK
IPC: G06Q30/04
Filed: 1992-05-06
Abstract: A distributed computer system employs a license management system to account for software product usage. A management policy having a variety of alternative styles and contexts is provided. Each licensed program upon start-up makes a call to a license server to check on whether usage is permitted, and the license server checks a database of the licenses, called product use authorizations, that it administers. If the particular use requested is permitted, a grant is returned to the requesting user node. The product use authorization is structured to define a license management policy allowing a variety of license alternatives by values called "style", "context", "duration" and "usage requirements determination method". The license administration may be delegated by the license server to a subsection of the organization, by creating another license management facility duplicating the main facility. The license server must receive a license document (a product use authorization) from an issuer of licenses, where a license document generator is provided. A mechanism is provided for one user node to make a call to use a software product located on another user node; this is referred to as a "calling card", by which a user node obtains permission to make a procedure call to use a program on another node.
Patent NZ-242644-A (NZ)
Title: Field repairable valve and seat in apparatus for filling containers to a predetermined level
Inventor: CAMPAU DANIEL N
IPC: H01M50/609
Filed: 1992-05-07
Abstract: An apparatus is disclosed for filling a container to a predetermined level with liquid provided from an external liquid supply means. The apparatus includes a main valve and a main valve seat for controlling the supply of liquid to the container. A lower valve housing is provided for supporting the main valve and main valve seat. An upper cap housing is also provided which is in fluid communication between the external liquid supply means and the main valve. Together, the lower and upper housings form a manually releasably connected valve assembly which is removably insertable into the container. <IMAGE>
Patent NZ-246429-A (NZ)
Title: Spinal fixation device, for interengaging a fixation rod with the spine, includes a groove in the lateral surface to engage the rod
Inventor: ASHMAN RICHARD B
IPC: A61B17/70
Filed: 1992-12-10
Abstract: A new spinal hook of the present invention which comprises a hook-configured shoe with an integral portion. The top portion includes a pair of central posts which are displaced to form a slot therebetween. Each central post includes a groove colinearly formed to receive a spinal rod within. The slot between the two posts is oriented with respect to the grooves so that an eyebolt assembly may be used to engage the hook to the fixation rod. In another aspect of the invention, a slot is formed in the end faces of the hook. The slot forms one part of a tongue and slot instrumentation engagement arrangement, with the hook-holding instrument including a correspondingly configured tongue. In another aspect of the invention, each of the pair of central posts include grooves on both lateral faces of the posts so that the spinal rod can be situated on either side of the spinal hook.
Patent NZ-257801-A (NZ)
Title: Continuous casting: molten metal cast onto vibrating casting surfaces with an arithmetic mean roughness value < 5 microns
Inventor: FREEMAN JOHN
IPC: B22D11/06
Filed: 1993-11-22
Abstract: PCT No. PCT/AU93/00593 Sec. 371 Date Aug. 15, 1994 Sec. 102(e) Date Aug. 15, 1994 PCT Filed Nov. 22, 1993 PCT Pub. No. WO95/09110 PCT Pub. Date Apr. 6, 1995.Method and apparatus for continuously casting metal strip (20) of the kind in which a casting pool of molten metal (30) is formed in contact with a moving casting surface. By making the casting surface (16A) very smooth and inducing relative vibratory movement between the molten metal and the casting surface at selected frequency and amplitude, the heat transfer from the solidifying metal is dramatically improved. The casting surface has an Arithmetical Mean Roughness Value (Ra) of less than 5 microus and the induced vibratory movement preferably has a frequency of no more than 20 kHz. This enables improved casting productivity and also produced a marked refinement of the surface structure of the cast metal.
Patent NZ-263740-A (NZ)
Title: Ionene polymers as anthelmintics
Inventor: DRAKE KEVIN D
IPC: A61P33/10
Filed: 1994-04-05
Abstract: The use of ionene polymers as anthelmintics is described. A composition for the treatment of helminth infections in an animal comprising an effective amount of at least one ionene polymer and a physiologically acceptable carrier other than water is disclosed. Also disclosed is a method for the treatment of a helminth infection in an animal.
Patent NZ-271301-A (NZ)
Title: Dehydrated oil-in-water emulsion and preparation: egg white, food acid and fat
Inventor: BAUER WERNER
IPC: A23L27/60
Filed: 1994-09-06
Abstract: The present invention relates to a food product which comes in the form of a dehydrated oil-in-water emulsion which can be reconstituted by adding water so as once again to form a stable emulsion of the mayonnaise or salad dressing type, and to a process for preparing the said dehydrated emulsion.
Patent NZ-275423-A (NZ)
Title: Use of pure alpha-1,4-glucan lyase for preparing 1,5-d-anhydrofructose
Inventor: YU SHUKUN
IPC: A23L27/30
Filed: 1994-10-15
Abstract: A method of preparing the sugar 1,5-D-anhydrofructose is described. The method comprises treating an  alpha -1,4-glucan with an  alpha -1,4-glucan lyase wherein the enzyme is used in substantially pure form. In a preferred embodiment, if the glucan contains links other than and in addition to the  alpha -1,4-links, the  alpha -1,4-glucan lyase is used in conjunction with a suitable reagent that can break the other links.
Patent NZ-277191-A (NZ)
Title: Enhanced rain-fastness biocides comprising secondary or tertiary alcohol surfactants, glyphosates, and tertiary alkylamine surfactants
Inventor: KASSEBAUM JAMES WEB
IPC: C05G5/00
Filed: 1994-11-30
Abstract: There is provided a new method of use of secondary or tertiary alcohol surfactants to enhance the efficacy and/or rainfastness of foliar-applied pesticidal and plant growth modifying agents. More specifically, there are provided new and useful compositions of such agents, in particular the herbicide N-phosphonomethylglycine or its salts or mixtures thereof, containing such efficacy-enhancing or rainfastness-enhancing surfactants.
Patent NZ-298639-A (NZ)
Title: Rapamycins substituted at C42 by =NOX or -NHOY, medicaments; 31-O-silyl-42-oxorapamycin precursors
Inventor: FAILLI AMEDEO ARTURO
IPC: A61P31/04
Filed: 1995-12-06
Abstract: This invention provides derivatives of rapamycin which are useful as immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumour agents having the structure detailed in formula 1.  In formula 1: X-Y is C=NOR1 or CHNHOR2 R1 and R2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, aminoalkyl of 1-6 carbon atoms, alkylaminoalkyl of 1-6 carbon atoms per alkyl group, dialkylaminoalkyl of 1-6 carbon atoms per alkyl group, cycloalkyl of 3-8 carbon atoms, alkyloxy of 1-6 carbon atoms, alkoxyalkyl of 1-6 carbon atoms per alkyl group, cycloalkylaminoalkyl of 4-14 carbon atoms, cyanoalkyl of 2-7 carbon atoms, fluoroalkyl of 1-6 carbon atoms, trifluoromethylalkyl of 2-7 carbon atoms, trifluoromethyl, ArO-, -(CH2)mAr, or -COR3; R3 is alkyl of 1-6 carbon atoms, -NH2, -NHR4, -NR4R5, -OR4 or Ar; R4 and R5 are each, independently, alkyl of 1-6 carbon atoms, Ar or if both are present can be taken together to form a 4-7 membered ring; Ar is an aryl or heteroaryl radical which may be optionally mono-, di-, or tri-substituted with a group selected from alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, arylalkyl of 7-10 carbon atoms, alkoxy of 1-6 carbon atoms, cyano, halo, hydroxy, nitro, carbalkoxy of 2-7 carbon atoms, trifluoromethyl, trifluoromethoxy, amino, dialkylamino of 1-6 carbon atoms per alkyl group, dialkylaminoalkyl of 3-12 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, alkylthio of 1-6 carbon atoms, -SO3H, and --O2H; And m=0-6
Patent NZ-325256-A (NZ)
Title: Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof
Inventor: GROTE THOMAS
IPC: C07C251/60
Filed: 1996-12-16
Abstract: The present relates to 2-iminooxyphenylacetic acid derivatives of the formula 1 where the substitutents are defined in the specification, and method of treating fungi and animal pests, and process for the preparation of the compound.
Patent NZ-333877-A (NZ)
Title: metal complex of a substituted indene derivative and use of the complex in an olefin polymerization process
Inventor: KLOSIN JERZY
IPC: C08F10/00
Filed: 1997-07-28
Abstract: The metal complex has the formula I wherein: M is Ti, Zr or Hf; j is 1 or 2; each RA is independently optionally substituted hydrocarbyl or hydrocarbylsilyl having up to 80 non-hydrogen atoms or two RA groups can be covalently linked with each other to form one or more fused rings or ring systems; RB, RW, RX, RY and RZ independently are H or optionally substituted hydrocarbyl, hydrocarbylsilyl having up to 80 non-hydrogen atoms or two or more of RB, RW, RX, RY and RZ groups can be covalently linked with each other to form one or more fused rings or ring systems; Z is a divalent moiety bound to both Cp and M via s-bonds with Z being boron or a member of group 14 of the periodic table of elements or nitrogen, phosphorus, sulphur or oxygen; X is anionic or di-anionic ligand group of up to 60 atoms exclusive of the class of ligands that are cyclic, delocalised p-bound ligands groups; each X' is independently a neutral lewis base ligating compound of up to 20 atoms; p is 0 to 2 and is two less than the formal oxidation state of M when X is an anionic ligand or when X is a di-anionic ligand group p is 1 and q is 0 to 2. The metal complex is used in a catalyst system for olefin polymerization which also contains a co-catalyst.
Patent NZ-501276-A (NZ)
Title: 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders
Inventor: BARRETT STEPHEN DOUGLAS
IPC: A61K31/351
Filed: 1998-06-24
Abstract: Phenylamino benzhydroxamic acid derivatives of formula (I) wherein:  R1 is hydrogen, C1-8 alkyl, C1-8 alkoxy, halo, trifluoromethyl or CN R2 is hydrogen R3, R4 and R5 are hydrogen, hydroxy, halo, trifluoromethyl, C1-8 alkyl, C1-8 alkoxy, nitro, CN, or (O or NH)m-(CH2)n-R9 where R9 is hydrogen, hydroxy, CO2H or NH10R11 n is 0 to 4 m is 0 or 1 R10 and R11 are hydrogen or C1-8 alkyl or taken together with the nitrogen to which they are attached can complete a 3 to 10 member cyclic ring optionally containing one, two or three additional heteroatoms selected from O, S, NH or N-C1-C8 alkyl. R6 is hydrogen, C1-8 alkyl, C(O)-C1-C8 alkyl, aryl, aralkyl or C3-10 cycloalkyl R7 is hydrogen, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 alkyl (cycloalkyl or cycloalkyl optionally containing a heteroatom selected from O, S or NR9).  Any of the foregoing alkyl, alkenyl and alkynyl groups can be unsubstituted or substituted by cycloalkyl (or cycloalkyl optionally containing a heteroatom selected from O, S or NR9), aryl, aryloxy, heteroaryl, or heteroaryloxy, or R6 and R7 taken together with the N-O to which they are attached can complete a 5 to 10 membered cyclic ring, optionally containing one, two or three additional heteroatoms selected from O, S, or NR10R11.  Such derivatives are potent inhibitors of MEK and are effective in treating cancer, proliferative diseases such as psoriasis and restenosis, heart failure, stroke, hepatomegaly, diabetes and Alzheimer's disease.
Patent NZ-502758-A (NZ)
Title: Hand-held module, for a question and answer game, comprising a slot for a card and a plurality of windows
Inventor: WHITE THOMAS
IPC: A63F9/18
Filed: 2000-02-09
Abstract: A hand held module 10 for use in a game comprises a slot 12 for receiving a printed card 14.  A first window 18 in one face of the module is for giving visual access to a first area of a card in slot 12.  A plurality of second windows 20 in the same face of the module is for giving visual access to second areas 32 of the card.  Each second window 20 has mean for marking selected ones of the second windows.
Patent NZ-507661-A (NZ)
Title: Drug inhaler having visible and/or audible toys that are activated during inhalation and exhalation
Inventor: WATT PAUL M
IPC: A61M15/00
Filed: 1999-04-20
Abstract: An incentive inhaler device (2) comprising (i) an inhalation device comprising a mask or mouthpiece (6) and a connector (4) that is linkable to a drug delivery device or other device for the delivery of an aerosol, powder or gas; and (ii) one or more external visible and/or audible inhalation/exhalation-driven incentive toys (12, 14), wherein each of said toys is separated from one or more components of said inhalation device (i) by one or more valves, filters or baffles (18, 24) to ensure directional flow of inhaled/exhaled air which drives said toys and/or filtration of microbes, condensation or particles from exhaled air. The incentive inhaler device (2) provides a stimulus to a child or infant to inhale a pharmacological or medicinal compound or anaesthetic compound and promotes correct breathing technique. The incentive inhaler device (2) further provides components and kits for use with the subject incentive inhaler device and methods of stimulating to a child or infant to inhale a pharmacological or medicinal compound or anaesthetic compound.
Patent NZ-507864-A (NZ)
Title: DADD, death activator death domain protein
Inventor: TELLIEZ JEAN-BAPTISTE
IPC: C12Q1/68
Filed: 1999-04-06
Abstract: An isolated polynucleotide encoding a protein having DADD protein activity is selected from: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 794 to nucleotide 3052; (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 1295 to nucleotide 3052; (d) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 2726 to nucleotide 2929; (e) a polynucleotide encoding a DADD protein comprising the ino acid sequence of SEQ ID NO: 13; (f) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 167 to amino acid 753; (g) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 645 to amino acid 712; and (h) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(g). Described are compositions comprising a protein having DADD protein activity which comprises an amino acid sequence selected from: (a) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13; (b) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 167 to amino acid 753; (c) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 645 to amino acid 712; and The composition can be used in the manufacture of a medicament for inhibiting a TNF-R DADD death domain promoter, preventing or ameliorating an inflammatory condition. Also described are methods for identifying inhibitors of binding of a DADD protein to a second protein having a death domain, and host cells, vector and antibodies of the polynucleotide and protein.
Patent NZ-508824-A (NZ)
Title: Use of optically pure (+)-norcisapride for treating apnea, bulimia and other disorders
Inventor: RUBIN PAUL D
IPC: A61P25/00
Filed: 1999-06-10
Abstract: The use of a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer, for the manufacture of a medicament for treating irritable bowel syndrome.
Patent NZ-510947-A (NZ)
Title: Method of using fetuin to induce apoptosis in cancer cells
Inventor: TSAI DAVID
IPC: A61P35/00
Filed: 1999-09-08
Abstract: The use of fetuin in the manufacture of a medicament for the treatment of cancer by inducing apoptosis in cancer cells. Also described is a preparation of fetuin from Fetal Bovine Serum.
Patent NZ-511210-A (NZ)
Title: Spinning oil containing fatty acid methyl esters for producing combed sliver
Inventor: BECKER WOLFGANG
IPC: D06M13/224
Filed: 1999-10-06
Abstract: C6-22 Fatty acid methyl esters based on coconut  fatty acids,  palm  kernel fatty acids, palm oil  fatty  acids  or mixtures  thereof optionally with additives and  emulsifiers are  used  as  smoothers in lubricants in the production  of combed  wool slivers which are further processed in  worsted wool yarn.
Patent NZ-514307-A (NZ)
Title: Expressing GP140 fragment of primary HIV-1 isolate
Inventor: SIA CHARLES D Y
IPC: C12N15/09
Filed: 2000-02-24
Abstract: A vector including a gene encoding the extracellular fragment gp140 of the primary HIV-1 isolate BX08 under the control of a promoter for expression of the gene product in a host organism.  Also disclosed is the use of such vector in the manufacture of an immunogen for generating a cytotoxic T-cell response to HIV1.