Patent SG-11201408237Y-A (SG)
Title: Compound as wnt signaling inhibitor, composition, and use thereof
Inventor: AN SONGZHU
IPC: A61K31/472
Filed: 2012-06-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185353 A1 (51) International Patent Classification: C07D 471/04 (2006.01) C07D 401/14 (2006.01) C07D 217/22 (2006.01) C07D 401/12 (2006.01) A61K 31/541 (2006.01) A61K 31/5377 (2006.01) A61K31/506 (2006.01) A61K 31/501 (2006.01) A61K31/4985 (2006.01) A61K 31/497 ( 2006.01) A61K31/496 (2006.01) A61K31/4725 (2006.01) A61K31/472 ( 2006.01) A61K31/444 (2006.01) A61K31/4375 (2006.01) A61P 43/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 27/02 (2006.01) A61P 25/16 (2006.01) A61P19/02 (2006.01) A61P17/00 (2006.01) A61P13/12 (2006.01) A61P1/16 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: PCT/CN2012/077032 15 June 2012 (15.06.2012) English English (26) Publication Language: (71) Applicant (for all designated States except US): CURE- GENIX INC. [CN/CN]; Building D, 10th Floor, Interna­ tional Business Incubator, Science City, Guangzhou, Guangdong 510663 (CN). (72) Inventor; and (75) Inventor/Applicant (for US only)-. AN, Songzhu [CN/CN]; Building D, 10th Floor, International Business Incubator, Science City, Guangzhou, Guangdong 510663 (CN). (74) Agent: BOSS & YOUNG PATENT AND TRADE­ MARK LAW OFFICE; 5/F., Tower A, Bldg. No. 1, GT International Center, Jia 3 Yongandongli, Jianguomenwai Avenue, Chaoyang District, Beijing 100022 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: COMPOUND AS WNT SIGNALING INHIBITOR, COMPOSITION, AND USE THEREOF Y?Y, m oo (I) i-H (57) Abstract: The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduc - © tion pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the compound CJ and the method of inhibiting the WNT signal transduction pathways.