baber/WOPTO huggingface dataset:
Patent PT-888309-E (PT)
Inventor: ELORANTA MAIRE MARJATTA
IPC: C07D233/56
Filed: 1996-10-02
Abstract: Imidazole derivatives of formula (I)wherein n is 0 or 1, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen or R2 and R3 together form a double bond, R3 is hydrogen or C1-C4-alkyl or R2 and R3 together form a double bond, R4 is hydrogen, C1-C4-alkyl, hydroxy or C1-C4-alkoxy, R5 is hydrogen or C1-C4-alkyl or R4 and R5 together with the carbon atom to which they are attached form a carbonyl group, R6, R7 and R8 are each the same or different and are independently hydrogen, C1-C4-alkyl or C2-C4-alkenyl, C3-C7-cycloalkyl, hydroxy, C1-C4-alkoxy, C1-C4-hydroxyalkyl, thiol, C1-4-alkylthio, C1-4-alkylthiol, halogen, trifluoromethyl, nitro or optionally substituted amino, X is -CHR9-(CHR10)m-, m is 0 or 1, and R9 and R10 are each the same or different and are independently hydrogen or C1-C4-alkyl; or a pharmaceutically acceptable ester or salt thereof, their preparation, use and pharmaceutical compositions comprising them are described. The compounds have affinity for alpha2 receptors and are useful e.g. in the treatment of hypertension, glaucoma, chronic or acute pain, migraine, diarrhea, common cold, ischemia, addiction to chemical substances, anxiety, especially preoperative anxiety and different neurological, musculoskeletal, psychiatric and cognition disorders or as adjuncts to anesthesia.
Patent PT-957900-E (PT)
Inventor: OSBORNE DAVID W
IPC: A61P29/00
Filed: 1997-09-10
Abstract: The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.
Patent PT-861603-E (PT)
Inventor: WU REI-YOUNG AMOS
IPC: A23L1/00
Filed: 1998-02-26
Abstract: A method for preparing a hand-held snack item comprises: (a) applying a first edible, heat-sensitive food material to an initial formed hand-held food item, thereby forming a preliminary coated hand-held food item; (b) applying a second edible food coating material to said preliminary coated hand-held food item, thereby forming a secondary coated hand-held food item, wherein said second edible food material is applied to said preliminary coated hand-held food item in such a manner as to substantially completely coat said first edible, heat-sensitive food material, and wherein said second edible food material is selected from a material which possesses sufficient physical characteristics to act as a protective medium for said first edible, heat-sensitive food material when said secondary coated hand-held food item is subjected to a temperature in the range of from about 35 DEG C to about 350 DEG C for a period of time in the range of from about 10 hours to about 30 seconds; and (c) subjecting said secondary coated hand-held food item to a temperature in the range of from about 35 DEG C to about 350 DEG C for a period of time in the range of from about 10 hours to about 30 seconds, thereby producing a final, coated hand-held snack item wherein said first edible, heat-sensitive food material is substantially intact. The present invention further relates to a hand-held snack item prepared by such method.
Patent PT-1082889-E (PT)
Inventor: MASCHIO GIORGIO
IPC: A01B33/14
Filed: 1999-09-08
Abstract: A system for the rapid coupling of blades for rotary harrows is described in which a coupling portion (4) of each blade (3a, b) is accommodated in respective seats (11) formed on a blade-carrying unit (2) and is restrained in the seat by at least one plug (13). The at least one plug is movable to and from an operative position in which it engages in a respective opening (8) and counter-opening (14) formed in the coupling portion (4) and in the blade-carrying unit (2), respectively, and return means (15) are provided for urging the at least one plug into the operative position. The opening may be constituted by recesses formed in an edge of the coupling portion of the blades. The rapid coupling system forming the subject-matter of the present invention can also be fitted directly to the flanged ends (10) of blade-driving shafts (10a) present on conventional rotary harrows.  <IMAGE>
Patent PT-1091913-E (PT)
Inventor: KO SUZ-CHUNG
IPC: C04B18/16
Filed: 1999-06-29
Abstract: The invention describes an activated supersulphated aluminosilicate binder containing aluminosilicates, calcium sulphate and an activator containing alkali metal salts, wherein the aluminosilicates are selected from the group consisting of blast furnace slag, clay, marl and industrial by-products such as fly ash with the proviso that the Al2O3 content is greater than 5% by weight, wherein blast furnace slag is present in an amount exceeding 35% by weight and clay, marl and/or fly ash is present in an amount exceeding 5% per weight and wherein cement kiln dust in an amount of from 3 to 10% by weight is added to the mixture as an activator and calcium sulphate is used in an amount exceeding 5% by weight.
Patent PT-1092767-E (PT)
Title: Serine protease-specific monoclonal antibody and utilization thereof
Inventor: KOMINAMI KATSUYA
IPC: G01N33/68
Filed: 1999-07-02
Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.
Patent SG-72992-G (SG)
Title: Wellhead valve
IPC: E21B47/10
Filed: 1992-07-16
Abstract: An improved wellhead valve (34) includes a tubularbody (38) with a central passage (46) therethrough and with a downwardly facing valve seat (52) surrounding a portion of the passage, a cylindrical sealing surface (50) above the valve seat, internal threads (48) above the sealing surface and external threads, a valve member (56) positioned within said passage below a valve seat and biased toward engagement with said valve seat, and a plug (70) having external threads for engagement with the internal threads of the body and having a sealing means (90) for sealing against the cylindrical sealing surface and a projection extending downwardly from said sealing means.The plug when positioned within the central passage (46) with its sealing means engages the sealing surface closing flow through the body (38) and the plug is movable downwardly so that its sealing means is below the sealing surface (50) and its projection engages the valve member (56) to move it out of engagement with the valve seat (52) so that flow through the central passage (46) is open and further rotation of the plug provides retrieval of the valve body from within the wellhead housing.
Patent IE-870121-L (IE)
Title: "aromatic benzamido compounds, a method for their¹preparation and their use in human and veterinary medicine¹and in cosmetics"
IPC: A61K8/60
Filed: 1987-01-20
Abstract: Aromatic benzamido compounds which have the formula: <IMAGE> in which: R1 denotes -CH2OH, -CHOHCH3 or -COR5, R5 denoting a hydrogen atom, a lower alkyl radical, the radical -OR6 or <IMAGE> R6 denoting a hydrogen atom, a lower alkyl radical or a mono- or polyhydroxyalkyl radical, r' and r'' denoting a hydrogen atom, a lower alkyl radical, a mono- or polyhydroxyalkyl radical, an optionally substituted aryl or benzyl radical, an amino acid or amino sugar residue or, taken together, form a heterocyclic ring, R2 denotes an alpha , alpha -disubstituted alkyl radical containing from 4 to 12 carbon atoms or a mono- or polycyclic cycloalkyl radical containing from 5 to 12 carbon atoms, whose linking carbon is quaternary, R3 denotes a hydrogen atom or an alkyl radical containing from 1 to 10 carbon atoms, and R4 denotes a hydrogen atom, a lower alkyl radical or a hydroxyl radical, and the salts of the said aromatic benzamido derivatives of formula (I) when R6 denotes a hydrogen atom. <??>These compounds find application in human and veterinary medicine and in cosmetics. 
[EP0232199A2]
Patent IE-890161-L (IE)
Title: 2-Amino Acetamide Derivatives
IPC: C07C231/00
Filed: 1989-01-19
Abstract: Compounds of general formula I, <CHEM>  wherein Ar1 and Ar2, which may be the same or different, represent phenyl optionally subsituted by fluorine, and R, R1, R2, R3 and R4 have the meanings given in the description, and pharmaceutically acceptable acid addition salts thereof, are useful as sedatives and in the treatment of epilepsy. The compounds are conveniently prepared by amide-forming reactions, and may be administered in the form of compositions comprising a pharmaceutically acceptable adjuvant, diluent or carrier.
Patent IE-31984-L (IE)
Title: Antibody fraction
IPC: C07K16/06
Filed: 1968-03-19
Abstract: 1,227,142. Separating IgM gamma globulins. POVIET PRODUCTION N.V. 25 March, 1968 [29 March, 1967; 5 Jan., 1968], No. 14317/68. Heading A5B. A so-called IgM gamma globulin fraction is separated from animal or human body fluids (milk, urine, plasma) by dialysis of the fluid against an aqueous medium with a pH of 4-9.5 either until the ionic strength of the fluid is 0.015 to 0.016 when the required fraction precipitates or by dialysing until the ionic strength is greater than 0.016 and diluting with water to the above ionic strength. In the latter case, the dialysis step may be that of electro-dialysis at pH 1.8 to 2.0. The precipitated material may be purified and worked up by conventional methods. It has haemagglutinating activity against colibacillus.
[GB1227142A]
Patent IE-40692-L (IE)
Title: 2-anilino benzotrifluoride derivatives; pesticides
IPC: C07C211/56
Filed: 1975-02-25
Abstract: 1430046 Substituted 2-anilino-3,5-dinitrobenzotrifluorides and their pesticidal compositions IMPERIAL CHEMICAL INDUSTRIES Ltd 18 Feb 1975 [7 March 1974 11 April 1974] 6 Nov 1974] 10241/74 16171/74 and 47976/74 Heading C2C The invention comprises dinitrobenzotrifluorides of Formula I wherein R represents a hydrogen atom or a C 1-6 alkyl or C 1-6 alkoxy group; X represents halogen atoms which may be the same or different; m is 0, 1, 2 or 3; n is 0 or 1; p is 0, 1, or 2 and q is 0, 1 or 2, the sun of m+n+p+q being 1, 2 or 3 provided that the group of Formula II is not a 4-cyano or 4-trifluoromethyl-2,6-dinitroanilino group, which compounds may be prepared by reacting a compound of Formula III with a compound of Formula IV or a compound of Formula V with a compound of Formula VI Y representing, in either case a halogen atom and the reactions optionally being carried out in the presence of a base and an inert solvent. Pesticidal and fungicidal compositions comprise as active ingredient a compound of Formula I together with a diluent or carrier and optionally at least one other biologically active ingredient such as an insecticide, acaricide or fungicide.
[GB1430046A]
Patent IE-860588-L (IE)
Title: Simultaneously dimerizing ethylene and copolymerizing¹ethylene with the dimer
IPC: C07C2/30
Filed: 1986-03-06
Abstract: A process for producing copolymers of ethylene and butene-1 wherein the butene-1 comonomer is generated in situ within the polymerization reactor by a separately catalyzed ethylene dimerization reaction.
[US4861846A]
Patent IE-820835-L (IE)
Title: Solid state load protection system
IPC: H02H6/00
Filed: 1982-04-07
Abstract: A solid-state load protection system having electronic simulation of motor M heating characteristics uses a current sensing function 14 so as to produce an output signal which is related to the current therein. Attached to the current sensing function 14 is an inverse time delay circuit 50 which has a signal path for charging and discharging a capacitor 26. Depending on the voltage across the capacitor which is related to the thermal state of the load, the inverse time delay circuit which is monitoring the voltage will initiate either a time-out or trip sequence of a reset sequence. The time before time- out or reset is proportional to the voltage across the capacitor. An output function 52 which is connected to the overcurrent and timing function upon receiving a trip signal causes a light emitting diode to conduct and also deenergizes a contactor 16 through which a current source is connected to the load. Upon receiving a reset signal the output function prohibits the light- emitting diode from conducting and energizes a contactor thereby connecting the current source with the load. <IMAGE>
[GB2097615A]
Patent IE-32201-L (IE)
Title: Regenerated cellulose sponge material
IPC: B29C44/00
Filed: 1968-07-18
Abstract: 1,197,611. Tampons. SPONCEL Ltd. 17 July, 1968 [19 July, 1967], No. 33095/67. Heading A5R. [Also in Division B5] In a process for the production of regenerated cellulose sponge material in strip form, a sponge forming mixture comprising viscose paste is extruded into a flexible reinforcing outer casing such that the paste is supported by said casing, and regeneration is effected whilst the reinforced strip is maintained having a predetermined cross-section. The viscose paste may contain reinforcing fibres and pore forming crystals, e.g. of sodium sulphate. The reinforcing casing may be an impermeable film, e.g. of polypropylene, PTFE or cellulose, removable after regeneration, or a woven fabric, e.g. woven cotton stockinet, which becomes bonded to the sponge. The strip may be impregnated with medicaments, humidifying agents, deodorants, odour producing substances or preservatives. Three examples are given and a specific product mentioned is catamenial tampons.
[GB1197611A]
Patent IE-39400-L (IE)
Title: Aromatic copolyesteramides
IPC: C08G18/38
Filed: 1974-05-30
Abstract: The invention concerns new difficulty inflammable polyesteramide filaments, threads, fibers and films.
[US3966685A]
Patent IE-871328-L (IE)
Title: Carbon monoxide-alkene polymers
IPC: C08G67/02
Filed: 1987-05-20
Abstract: Process for the preparation of polymers characterized in that a mixture of carbon monoxide with one or more olefinically unsaturated organic compounds is polymerized by contacting the mixture with a catalyst composition based upon a) a palladium compound, b) an anion of an acid with a pKa of less than 2, provided that the acid is not a hydrohalogenic acid, and c) a bidentate ligand of the general formula R<1>R<2>-M-R-M-R<3>R<4>, wherein M represents phosphorus, arsenic or antimony, R<1>, R<2>, R<3> and R<4> represent hydrocarbyl groups which may or may not be substituted with polar groups and R represents a bivalent organic bridging group which contains at least two carbon atoms in the bridge in the absence of a liquid non-polymerizable diluent.
[EP0248483A2]
Patent IE-38074-L (IE)
Title: Delta 8(9)-steroids of the pregnane series.
IPC: C07J21/00
Filed: 1973-08-10
Abstract: 1440064 A<SP>8(9)</SP>-Steroids of the pregnane series GLAXO LABORATORIES Ltd 10 Aug 1973 [11 Aug 1972] 37656/72 Heading C2U [Also in Division A5] Novel steroids of the formula wherein R 1 is -COC 2 H 5 or -COC 3 H 7 (n- or iso-) and R 2 is H, -COCH 3 , -COC 2 H 5 or -COC 3 H 7 (n- or iso-) are prepared (1) by dehydrohalogenation of steroids of the formula (wherein X is Cl or Br) which may in turn be prepared by addition of HOX to the corresponding 9,11-unsubstituted-#<SP>9(11)</SP>-steroids; or (2) by conversion of corresponding 17 α,21-diols to ortho-esters by reaction with R<SP>1</SP>C(0R<SP>11</SP>) 3 wherein R<SP>1</SP> is C 2 H 5 , n-C 3 H 7 or iso-C 3 H 7 and R<SP>11</SP> is C 1-4 alkyl followed by hydrolysis to give 17α- acyloxy-21-ols as products which may subsequently be 21-acylated. Starting materials corresponding to the first structural formula above but containing a free 17α-OH group are prepared by method (1) above using a free 17α-ol starting material. 11#,17α,21- Trihydroxy - 16# - methylpregna - 1,4,8(9)- triene-3,20-dione is prepared by hydrolysis of the corresponding 21-acetate. 16#-Methyl- 17 α,21 - dipropionylocypregna - 1,4,9(11) - triene - 3,20- dione is prepared by acylation of the corresponding 21-ol. The corresponding 21-acetate is prepared similarly. 9α-Bromo- 11#-hydroxy- 16# - methyl - 17 α,21 - dipropionyloxypregna- 1,4-diene-3,20-dione is also prepared similarly. The novel steroids are anti-inflammatory agents and may be made up into pharmaceutical compositions with suitable carriers (see Division A5).
[GB1440064A]
Patent IE-891446-L (IE)
Title: Adhesive compositions
IPC: C08F30/02
Filed: 1989-05-03
Abstract: A single-component, visible light-curable liquid adhesive composition comprises (a) 2 to 20 parts by weight of at least one substantially pure phosphate ester having the formula CH2=C(R<1>). CO.O.R<2>. OP(O) (OH)2 in which R<1> is a hydrogen atom or a methyl group, and R<2> is -CH2-CH2-, -CH2-CH(CH3)- or -CH(CH3)CH2- and (b) 98 to 80 parts by weight of at least one ethylenically unsaturated monomer copolymerisable with the phosphate ester (c) 1 to 9% by weight of fine inorganic filler and an effective amount of a visible light activated catalyst.
[DE3914687A1]
Patent IE-801510-L (IE)
Title: Process for the manufacture of sodium silicate
IPC: C01B33/32
Filed: 1980-07-21
Abstract: The present invention comprises a process for the manufacture of a sodium silicate solution in a continuous manner from a silicon dioxide-containing material, comprising continuously adding to a reaction zone a stream of said silicon dioxide-containing material and a stream of a sodium hydroxide-sodium carbonate solution, reacting said silicon dioxide-containing material and said sodium hydroxide-sodium carbonate at a temperature and pressure and for a time sufficient to form a sodium silicate solution, and recovering said sodium silicate solution from the reaction zone.
[US4336235A]
Patent IE-36980-L (IE)
Title: Isolation of orgotein from animal tissue
IPC: A61K35/12
Filed: 1972-12-04
Abstract: 1409925 Orgotein DIAGNOSTIC DATA Inc 6 Dec 1972 [7 Dec 1971] 56242/72 Heading C3H A process for the isolation of orgotein from animal tissue involves subjecting a mixture of orgotein and other buffer-soluble proteins from ground up animal tissue to a chromatographic separation by (a) contacting the mixture of buffer-soluble proteins as an aqueous solution (pH of approximately 6) having an ionic strength of less than about 0.01 M with an ion exchange resin (column) having weakly basic groups, thereby adsorbing the orgotein and a portion of the other proteins (haemoglobin and myoglobin) in the mixture on the resin; (b) eluting a portion of the adsorbed proteins from the resin with an aqueous eluant having a pH of approximately 6 and an ionic strength below about 0.02 M; (c) eluting another (orgotein-containing) portion of the adsorbed proteins from the resin with an aqueous eluant having a pH of approximately 6 and a higher ionic strength (of between about 0.02 M and about 0.03 M) than the eluant used in step (b) while monitoring at least one of the A 265 and A 280 absorbances and measuring a proteinbound divalent metal (Cu or Zn) content of the eluate; and (d) separating from the eluate from step (c) the orgotein-containing fraction having an enhanced protein-bound divalent metal content and a diminished A 265 or A 280 adsorbance. If desired, the starting mixture of extracted proteins can be purified with respect to orgotein by fractionation with ammonium sulphate and the substantially pure orgotein product isolated by the process set forth may be further purified by gel filtration or other conventional techniques (described). The preferred ion exchange resins are tertiary or quaternary amino-celluloses and -dextrans (specified). The term "animal tissue" is defined as excluding blood and blood fractions. The preferred material is bovine liver.
[GB1409925A]
Patent IE-801688-L (IE)
Title: Purifying lead chloride.
IPC: C22B3/00
Filed: 1980-08-12
Abstract: A process for the treatment of solutions of lead chloride, containing as impurities at least one metal chosen from the group consisting of silver, copper and bismuth. This process is characterized by the fact that it involves the following steps: (a) bringing the solution into contact with a cation exchange resin whose active group is a sulfhydryl group; and (b) recovery of the lead on the basis of the solution obtained in step (a).
Patent IE-781955-L (IE)
Title: Isolating pseudomonic acid
IPC: C12P17/16
Filed: 1978-09-29
Abstract: A process for the purification of pseudomonic acid, particularly suitable for isolating the compound when prepared by bacterial culture, comprises making a solution in an organic solvent of the acidic components of the crude preparation substantially free of the neutral components. The polarity of the organic solvent is adjusted so that the pseudomonic acid crystallizes. This may be achieved either by adding a non-polar diluent such as n-heptane to the solution for example in methyl iso-butyl ketone; or by employing a di-C1-6 alkyl ether in which the acidic components dissolve and then crystallize out.
[US4222942A]
Patent IE-841985-L (IE)
Title: Immunogenic composition comprising live encysted protozoa
IPC: A23K1/00
Filed: 1984-08-08
Abstract: An oral vaccine against parasitic protozoa, such as coccidia, comprises live encysted protozoa embedded in a firm gel matrix from which the protozoa are released following ingestion by a host. The gel matrix helps to maintain the essential viability of the protozoa without seriously hindering the natural mechanism by which they infect their host. Preferably the gel matrix is based on alginate. Alginate beadlets containing viable sporulated coccidia oocysts, for administration to poultry, are a preferred feature.
Patent IE-821995-L (IE)
Title: Dental prosthesis adhesive
IPC: A61K6/00
Filed: 1982-08-18
Abstract: The invention relates to a dental prosthesis adhesive formed for one or more adhesive substances and characterized in that at least a part of the adhesive substance or substances are provided with a coating which dissolves slowly in saliva and/or ingestive liquids. Preferably the coating for the adhesive substance contains one or more substances selected from the group consisting of ethyl cellulose, saccarose monostearate, gum arabis, cellulose acetate phthalate, acrylate, methacrylate, shellac or other film providing substances.
[EP0073850A1]
Patent IE-902097-L (IE)
Title: Thienopyran derivatives
IPC: A61K31/38
Filed: 1990-06-11
Abstract: Thienopyran derivatives of the general formula   <IMAGE> I  in which the radial  <IMAGE>  denotes one of the formulae  <IMAGE>  R denotes hydrogen or a radical -CN, -CHO, -CH=NOH, -CONH2 or -COOR1, R1 denotes the radical (C1-C4)-alkyl and n denotes an integer 3, 4 or 5, and a process for their preparation, pharmaceutical preparation and their use for the treatment of diseases which can be cured by activation of membrane K+ channels, such as high blood pressure and asthma.