baber/WOPTO huggingface dataset:
Patent BR-PI1005543-B1 (BR)
Title: Método, aparelho e sistema
Inventor: ALEXANDRE J FARCY
IPC: G06F9/315
Filed: 2010-12-22
Abstract: instruções de rotação que completam a execução sem a leitura do flag de transporte. a presente invenção refere-se a um método de um aspecto pode incluir o recebimento de uma instrução de rotação. a instrução de rotação pode indicar um operando fonte e uma quantidade de rotação. um resultado pode ser armazenado em um operando de destino indicado pela instrução de rotação. o resultado pode ter o operando fonte tendo execução da instrução de rotação pela quantidade de rotação. a execução da instrução de rotação pode ser concluída sem a leitura de um flag de transporte.
Patent BR-PI1005767-B1 (BR)
Title: método de indexação para dados de alta dimensionalidade em grandes bases de dados usando uma curva de peano (curva preenchedora do espaço) e múltiplos representantes para os dados
Inventor: Eduardo Alves Do Valle Junior
IPC: G06F7/00
Filed: 2010-12-20
Abstract: MÉTODO DE INDEXAÇÃO PARA DADOS DE ALTA DIMENSIONALIDADE EM GRANDES BASES DE DADOS, USANDO UMA CURVA DE PEANO (CURVA PREENCHEDORA DO ESPAÇO) E MÚLTIPLOS REPRESENTANTES PARA OS DADOS. O presente invento resolve o problema da indexação de dados de alta dimensionalidade usando curvas de Peano. Essas curvas têm a capacidade de induzir uma ordem total nos dados "sensível à vizinhança" que pode ser aproveitada na indexação de registros multidimensionais. Entretanto elas possuem "zonas de descontinuidade" onde essas qualidades de quase preservação da vizinhança são perdidas. O invento resolve, de maneira eficiente e eficaz, o problema das regiões de descontinuidade, permitindo o uso efetivo das curvas de Peano na indexação de dados de alta dimensionalidade.
Patent BR-PI1010772-B1 (BR)
Title: compostos de quinolina, suas composições farmacêuticas e seus usos para tratar aids
Inventor: AUDE GARCEL
IPC: C07D401/12
Filed: 2010-06-14
Abstract: COMPOSTO, E, COMPOSIÇÃO FARMACÊUTICA. A presente invenção diz respeito ao composto de formula (I) em que a formula II: significa um grupo piridazina, pirimidina ou pirazina, R independentemente representa um átomo de hidrogênio, um átomo de halogênio ou um grupo escolhido entre grupo -CN, um grupo hidroxila, um grupo -COOR1, um grupo fluoralquila (C1-C3), um grupo fluoralcóxi (C1-C3), um grupo -NR1R2, um grupo alcóxi (C1,C4), um grupo fenóxi e um grupo hidroxila, n é 1, 2 ou 3, n é 1 ou 2, R é um átomo de hidrogênio,um átomo de halogênio ou um grupo escolhido entre um grupo alquila (C1-C3), um grupo hidroxila, um grupo -COOP1, um grupo -NO2, um grupo -NRlr@, um morfolinila ou, um grupo N- metilpiperazinila, um grupo fluoralquila (C1-C3), um grupo alcóxi (C1-C4) e um grupo -CN, Z é N ou C, Y é N ou C, x é N ou C, W é N ou C, t é N ou C, U é N ou C, para uso como um agente para prevenir, inibir ou tratar AIDS. Alguns dos ditos compostos são novos e também formam parte da invenção.
Patent BR-PI1013555-B1 (BR)
Title: Dispositivo de controle de entrada de ar para motor
Inventor: HIROSHIGE AKIYAMA
IPC: F02D9/10
Filed: 2010-03-15
Abstract: dispositivo de controle de entrada de ar para motor. em um dispositivo de controle de entrada de ar para um motor, um corpo de estrangulamento (1) inclui uma parte de cilindro (1a) e uma parte de flange (1b) que se salientam de uma periferia externa de uma parte de extremidade da parte de cilindro (1a) e tendo uma superfície de extremidade em uma forma substancialmente quadrada; primeira e segunda reentrâncias de fixação (2, 2') são integralmente formadas, respectivamente, nas partes de canto da parte de flange (1b), as partes de canto sendo posicionadas, respectivamente, nas posições diagonais da parte de flange (1b); primeira e segunda reentrâncias (9, 9') apoiando uma haste de válvula (8a) de uma válvula de estrangulamento (8) são formadas sobre a parte de flange (1b) da parte de cilindro (1a); uma de uma reentrância de batente de fechamento total (20) e uma reentrância de escora (15) que são posicionadas de modo a interpor a primeira reentrância de suporte (9) é continuamente provida na primeira reentrância de fixação (2) na parte de flange (1b), enquanto a outra é formada na parte de flange (1b); um parafuso de batente (21) para restringir uma posição de fechamento total da válvula de estrangulamento (8) é aparafusado ao batente de fechamento total (20); e um parafuso (16) que fixa uma escora do tubo-guia (13) que sustenta um tubo-guia (12) do fio de operação (11) é aparafusado à reentrância da escora (15). com essa configuração é possível uma redução no tamanho do corpo de estrangulamento.
Patent EA-006582-B1 (EA)
Title: Pharmaceutical disinfective preparation based on usnic acid sodium salt and medical plants and methods for preparation thereof
Inventor: STANKOVIC SLOBODAN
IPC: A61K36/235
Filed: 2000-11-03
Abstract: The process relates to the pharmaceutical disinfective preparations on the basis of usnic acid sodium salt and medical plants, in particular, Mentha piperita L., or menthol, which are used as a common disinfective agent for external use in treatment of inflammation of the upper respiratory tract and oral cavity, caused by the action of pathogenic microorganisms as well as in cosmetics. The invention presents the procedures for obtaining of the preparations in the form of: chewable tablets, tablets, gel, aerosol, as a base for aromatic-antiseptic liquid for disinfection and external use.
Patent EA-007577-B1 (EA)
Title: Adhesive polymer composition
Inventor: ANKER MARTIN
IPC: C08L23/16
Filed: 2002-11-14
Abstract: The present invention relates to an adhesive polymer composition comprising a) a non-elastomeric polyethylene in an amount of 40 to 97 wt.% of the total composition and b) an elastomer comprising an elastomeric ethylene copolymer with polar comonomer groups, wherein component a) has been produced in a process using a single-site catalyst and component a) or components a) and b) have been grafted with an acid grafting agent. Furthermore, the invention relates to an article, in particular a multilayer pipe, comprising an adhesive layer which comprises said adhesive polymer composition and to the use of said adhesive polymer composition for the production of an adhesive layer, in particular of an adhesive layer of a pipe.
Patent EA-021644-B1 (EA)
Title: Human monoclonal antibody against cd20 and use thereof
Inventor: TEELING JESSICA
IPC: A61K39/00
Filed: 2003-10-17
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Patent EA-006567-B1 (EA)
Title: Hydraulic fracturing method
Inventor: MORALES HUGO
IPC: E21B43/26
Filed: 2003-10-21
Abstract: The present invention relates to a method of designing a hydraulic fracturing treatment in a subterranean reservoir comprising the steps of a) quantifying reservoir parameters including the bottomhole temperature and the formation permeability, b) assessing the temporary variation in temperature of the formation due to the injection of a treatment fluid and c) designing a fluid optimized for said temporary temperature.
Patent EA-009774-B1 (EA)
Title: Game machine and article for game
Inventor: YAGI KENICHI
IPC: G07F17/32
Filed: 2005-12-27
Abstract: A gaming machine includes; a read means for reading game information concerning a game from a game article including a main body section having an incidence section for introducing light incident from the outside into the inside and an emission section for emitting light incident from the incidence section and passing through the inside to the outside and a storage section for storing the game information concerning a game; a light emission mode determination means for determining a light emission mode of a light emission body for emitting light to the incidence section of the game article based on the game information read through the read means; and a light emission control means for controlling the light emission of the light emission body in accordance with the light emission mode determined by the light emission mode determination means.
Patent EA-014555-B1 (EA)
Title: Bcrp/abcg2 inhibitors
Inventor: NISHIYAMA YUKIKO
IPC: A61K31/277
Filed: 2006-03-29
Abstract: Disclosed is a breast cancer resistant protein (BCRP/ABCG2) inhibitor. A BCRP inhibitor comprising an acrylonitrile derivative represented by the general formula (1) or a salt thereof as the active ingredient: (1) (E or Z) wherein one of R1 and R2 represents a cyano group and the other represents a hydrogen atom; Arrepresents a group selected from the groups represented by the formulae (2) to (4) below; and Arrepresents an aromatic hydrocarbon group which has a fused ring optionally substituted by a halogen atom or a group selected from the groups represented by the formulae (5) to (15) below.
Patent EA-017751-B1 (EA)
Title: Use of heterocyclic compound having specific structure for inhibiting amyloid beta deposition and method for inhibiting amyloid beta deposition using said compound
Inventor: YAMAGUCHI YOSHIMASA
IPC: A61K31/429
Filed: 2007-10-15
Abstract: Disclosed is use and method for inhibiting amyloid β deposition containing a heterocyclic compound having the general formula (IV)
Patent EA-019085-B1 (EA)
Title: 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
Inventor: CID-NUNEZ JOSE MARIA
IPC: A61K31/44
Filed: 2008-09-12
Abstract: The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I), wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
Patent EA-023188-B1 (EA)
Title: Press for producing pressure for processing a workpiece
Inventor: MATASSONI PAOLO
IPC: B30B1/42
Filed: 2010-12-02
Abstract: The invention relates to a press for producing pressure for processing a workpiece, the press has a press table (10), a press a frame (12), a slide (16) and linear-electric motors (20) for driving the slide (16) and an upper cross-arm (14) positioned above the table (10), wherein a working zone is formed between the table (10) and the upper cross-arm (14) for processing a workpiece, and a part of the linear-electric motors (20) is integrated in the upper cross-arm (14), while the rest part is integrated in the press table (10), wherein all linear-electric motors (20) are connected to the slide (16) and emboded as a servo-motor, each linear-electric motor comprises multiple magnetic poles (70, 72, 74, 76, 78, 80), that are arranged and shifted to each other, and a part (24) linearly shifted by said poles (70, 72, 74, 76, 78, 80), wherein the magnetic poles (70, 72, 74, 76, 78, 80) of at least one linear-electric motor (20) are formed by coils (84, 86, 88), extending around an axis (82), the coils are axially arranged and shifted to each other with respect to the axis (82), wherein the linearly shifted part (24) extends in the direction of the axis (82) and is linearly adjustable in the direction of the axis (82) by the coils (84, 86, 88) of the poles.
Patent EA-026064-B1 (EA)
Title: Solid pharmaceutical formulation obtainable by pre frozen step and lyophilisation step
Inventor: NOURRISSON DIDIER
IPC: A61P35/00
Filed: 2009-04-03
Abstract: The present invention relates to a solid pharmaceutical formulation stable for at least 24 months for the treatment and/or prevention of chronic disorders or diseases comprising 1 to 50 wt.% of a chimeric molecule of dopamine-somatostatin and 50-95 wt.% of at least one sugar or polyol or a mixture thereof.
Patent EA-023661-B1 (EA)
Title: PACKAGED SOLUTION FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA, COMPRISING PGF2α ANALOGUE
Inventor: REUNAMAKI TIMO
IPC: A61K47/26
Filed: 2009-05-28
Abstract: The present invention relates to a packaged ophthalmic aqueous solution for treating ocular hypertension and glaucoma, the solution comprising PGF2α analogue as an active ingredient, wherein said solution contains 0.05 to 0.5% (w/v) of nonionic surfactant selected from the group consisting of polyoxyethylene fatty esters such as polysorbate 80 [poly(oxyethylene)sorbitan monooleate], polysorbate 60 [poly(oxyethylene)sorbitan monostearate], polysorbate 40 [poly(oxyethylene)sorbitan monopalmitate], poly(oxyethylene)sorbitan monolaurate, poly(oxyethylene)sorbitan trioleate and polysorbate 65 [poly(oxyethylene)sorbitan tristearate], and polyoxyethylene hydrogenated castor oils such as polyoxyethylene hydrogenated castor oil 10, polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 50 and polyoxyethylene hydrogenated castor oil 60, 0.005 to 0.2% of stabilizing agent and substantially no preservatives wherein the solution is packaged in a container consisting of not more than 10% of material other than polyethylene.
Patent EA-019268-B1 (EA)
Title: Combined preparation manifesting hepatoprotective action
Inventor: KUPSIN EVGENIY VENIAMINOVICH
IPC: A61P1/16
Filed: 2010-12-01
Abstract: The invention relates to medicine, in particular, to hepatology and pharmacology and can be used for preparing a combined medicament manifesting hepatoprotective action. A combined capsule-formed medicament manifesting hepatoprotective action is claimed comprising essential phospholipids, L-carnitine or tartrate L-carnitine and as active ingredients and magnesium stearate as an auxiliary substances with the following ratio, wt%: essential phospholipids – 60.0-72.0; L-carnitine or tartrate L-carnitine – 20.0-25.0; DL-alpha-tocopherol acetate – 0.5-1.5; the auxiliary substances - remaining; binar preparation consisting of two capsules, the first capsule comprises (wt%): essential phospholipids – 85.0-95.0; DL-alpha-tocopherol acetate – 1.0-1.7; the auxiliary substances - remaining; the second capsule comprises L-carnitine - 300-1000 g. The use of the combined medicament is applied in a complex therapy for the treatment of fatty hepatosis and toxic hepatitis of various etymology. The claimed invention provides substantial reduction of hepatocyte and cholestasis cytolisis thus proving high regeneration functional hepatocyte activity stipulated by potentiating influence of active ingredients comprising said composition: essential phospholipids, tocopherol and carnitine leading, in particular, to decreasing disease duration, substantial recovery acceleration and normalization of patient vitality.
Patent EA-021428-B1 (EA)
Title: A microfluidic-channel embeddable, laterally oscillating micro-electromechanical gravimetric sensor device for detecting biological cells and analytes
Inventor: KULAH HALUK
IPC: G01N29/02
Filed: 2009-08-20
Abstract: Laterally oscillating micro-electromechanical gravimetric sensing device embeddable under micro-fluidic channels and fabricated with micro-electromechanical systems (MEMS) technology, which detects biological cells and analytes by measuring the change of mass attached on its surface is composed of four main groups, namely a resonator that can be placed onto the basis of the channel, components of the resonator bio-activation, a micro-fluidic channel, and the micro-fabrication techniques, and its main components are the proof mass (1), comb fingers fixed to proof mass (2), folded spring beams (3), channel floor and mechanical soil (4), stationary electrodes (5), comb fingers attached to the stationary electrodes (6), golden film deposited onto the mass (7), immobilized biologic recognition molecules (8), and micro-fluidic channel placed on resonator structure (9).
Patent EA-020161-B1 (EA)
Title: Process for the preparation of calcobutrol
Inventor: PLATZEK JOHANNES
IPC: A61K49/10
Filed: 2010-11-02
Abstract: The invention concerns a process for the preparation of the calcium complex of 10-(2,3-dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-1,4,7-triacetic acid (calcobutrol), wherein: a) the gadolinium complex of 10-(2,3-dihydroxy-l-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-l,4,7-triacetic acid (gadobutrol) is decomplexed with a decomplexing agent at 75 to 100°C forming a precipitated gadolinium salt, b) the precipitated gadolinium salt is removed, c) the solution resulting from step b) is bound to an acidic ion exchange resin at pH 3.65-3.80 sorbing ligand, d) said ligand is eluted with an aqueous alkaline solution, e) the eluate is treated with acidic ion exchange resin, obtaining the solution comprising ligand, and f) the ligand is complexed with Caions at 75 to 100°C and crystallised the obtained complex. The invention furthermore concerns calcobutrol with a hitherto unknown level of purity.
Patent EA-025261-B1 (EA)
Title: Laboratory extruder
Inventor: SCHOLTENS BOUDEWIJN JAN ROBERT
IPC: B30B11/22
Filed: 2012-08-29
Abstract: The invention relates to an extruder for processing relatively small quantities of pharmaceutical and/or biomedical materials, which extruder comprises an extruder frame, a barrel, a pair of extruder screws, and a drive for rotating the extruder screws, wherein the barrel is formed by a pair of separable housing blocks that are positioned in a closed position against each other during processing, each housing block having a barrel liner, wherein in the closed position of the pair of separable housing blocks the barrel liners define an interior volume, a feed opening, a discharge opening and an opening for receiving the pair of extruder screws in the interior volume.
Patent EA-027158-B1 (EA)
Title: Method for diagnosing osteoporosis and method for defining the effectiveness of a preparation for treating osteoporosis
Inventor: STRUKOV VILLORIJ IVANOVICH
IPC: G01N23/083
Filed: 2012-08-21
Abstract: The invention relates to the field of medicine for diagnosing osteoporosis and for defining the effectiveness of preventive action, which has been carried out, on conditions associated with osteoporosis. The problem addressed by the claimed invention is that of objectively assessing the effectiveness of the action of (a) preparation(s) (an osteoprotector) and of detecting cavity formations in trabecular sections of bones. It is proposed to improve the diagnostic possibilities of computer osteometers by detecting cavity formations in the event of osteoporosis and defining the severity of the disease not only on the basis of mineral density, but also on the basis of the presence of cavities in trabecular sections of bones. The method for diagnosing osteoporosis is carried out by an X-ray absorption method on an osteometer, to which the presence of cavity formations in trabecular sections of bones is introduced as an additional diagnostic criterion of osteoporosis, and diagnosing is performed using the osteometer. The method for defining the effectiveness of a preparation for treating osteoporosis involves the dynamics control thereof by an X-ray absorption method on an osteometer, the effectiveness of the preparation being defined by the dynamics of closing cavity formations in trabecular sections of bones.
Patent EA-031006-B1 (EA)
Title: Anti-cd134 (ox40) antibodies and uses thereof
Inventor: SIMONS PETRUS JOHANNES
IPC: C07K16/28
Filed: 2012-09-13
Abstract: The present invention provides antibodies or antigen-binding fragments of the antibodies that specifically bind to human CD134 and comprise a heavy chain variable region comprising CDR1, CDR2 and CDR3 of the heavy chain comprising the amino acid sequences of SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8, respectively; and a light chain variable region comprising CDR1, CDR2 and CDR3 of the light chain comprising the amino acid sequences of SEQ ID NO: 9, SEQ ID NO: 10 and SEQ ID NO: 11, respectively. The anti-human CD134 antibodies according to the present invention specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134 molecule, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 T lymphocytes (Tregs). The anti-human CD134 antibodies according to the present invention are useful for cancer treatment (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function).
Patent EA-026537-B1 (EA)
Title: Insulating element for the insulation of flat roofs
Inventor: NIELSEN DAG
IPC: E04D13/16
Filed: 2012-12-21
Abstract: A thermal insulating element comprising an insulating layer having a first face and a second face, said insulating layer comprising a coherent man-made vitreous fibre-containing insulating material and at least one reinforcing element extending substantially from the first face to the second face of the insulating layer, wherein the reinforcing element comprises a polymeric foam composite material, the composite material comprising a polymeric foam and man-made vitreous fibres produced with a cascade spinner or a spinning cup, wherein at least 50% by weight of the man-made vitreous fibres present in the polymeric foam composite material have a length less than 100 micrometers.
Patent EA-025859-B1 (EA)
Title: Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor
Inventor: COURVOISIER LAURENT
IPC: C07D403/04
Filed: 2013-03-06
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
Patent EA-033760-B1 (EA)
Title: Method of producing follicular protein preparation and preparation produced by said method
Inventor: ILYICHEV ALEXANDER VLADIMIROVICH
IPC: B01D21/26
Filed: 2015-02-26
Abstract: The invention relates to the production of a follicular protein preparation for treating endometriosis by a method according to which the bovine follicular fluid is centrifuged, the resultant supernatant is cooled down to 4-8°C and mixed with acetone cooled down to -18°C, settled, repeatedly centrifuged, the resultant sediment is lyophilized, the lyophilisate is dissolved in the buffer, the resultant suspension is centrifuged at 8000-10000 g for 15-30 min, the resultant supernatant is subjected to ion exchange chromatography on DEAE-Sepharose, eluate is collected and dialyzed against water for not less than 8 hours, the resultant dialysate is frozen and then freeze-dried. The invention also relates to a follicular protein preparation obtained from bovine follicular fluid, the preparation comprising serum albumin and a protein of the TGF-β family having inhibin βA immune specificity.