baber/WOPTO huggingface dataset:
Patent DE-69032616-D1 (DE)
Inventor: LAWLIS VIRGIL
IPC: C12P21/00
Filed: 1990-06-14
Granted: 1998-10-08
Abstract: The invention includes novel fusion DNA sequences encoding fusion polypeptides which when expressed in a filamentous fungus result in increased levels of secretion of the desired polypeptide as compared to the expression and secretion of such polypeptides from filamentous fungi transformed with previously used DNA sequences. The fusion DNA sequences encode a fusion polypeptide comprising, from the amino to carboxyl-terminus, first, second, third and fourth amino acid sequences. The first DNA sequence encodes a signal peptide functional as a secretory sequence in a first filamentous fungus. The second DNA sequence encodes a secreted polypeptide or portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third DNA sequence encodes a cleavable linker polypeptide while the fourth DNA sequence encodes a desired polypeptide.
Patent DE-69100955-D1 (DE)
Inventor: PEREZ PASCUAL MIGUEL A
IPC: C07C69/54
Filed: 1991-02-19
Granted: 1994-02-24
Abstract: It comprises reacting, both continuously and discontinuously, acrylic acid and 1-butene in the presence of an ionic exchange resin that contains sulfonic acid, carrying out the reaction at a temperature between 50 and 120o C, at a pressure between 10 and 30 kg/cm<2>, for a reaction or contact time between 0.5 and 4 hours and using a olefin/acrylic acid molar ratio between 0.3 and 10. The sec-butyl acrylate obtained is useful in polymerization processes yielding very hard polymers with a high thermal resistance and high resistance to hydrolysis. Fig. 1 represents a graph of the effect of the olefin/acrylic acid ratio over the conversion of acrylic acid. <IMAGE>
Patent DE-69105202-D1 (DE)
Inventor: SORENSON PAUL
IPC: A61N1/32
Filed: 1991-03-22
Granted: 1994-12-22
Abstract: A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level to maintain a desired steady-state therapeutic level of the agent. One embodiment provides that the initial interval is maintained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief interval of increased iontophoretic current level to attain a brief interval of increased dosage.
Patent DE-69116114-D1 (DE)
Inventor: LAPOINTE LARRY PATRICK
IPC: A47C4/02
Filed: 1991-11-26
Granted: 1996-02-15
Abstract: An improved locking mechanism for detachably securing a seat back (18) to a chair frame is disclosed. The improved locking mechanism includes a pair of slide brackets (54) secured to opposite sides of the seat back (18). Linkages (20) supported from the chair frame are provided for receiving the slide brackets (54) thereon for supporting the seat back (18) on the chair frame in a predetermined orientation relative to the seat member. A moveable locking arm (72) is supported from the slide brackets (54) and includes an offset arcuate cam surface (75) which is adapted to engage an arcuate notch (76) formed on the linkage (20) when the locking arm (72) is moved to a locked position. The mating engagement of the arcuate offset cam surface (75) within the arcuate notch (76) generates a line-of-contact therebetween which inhibits relative movement between the slide brackets (54) and the upstanding links (20) for rigidly securing seat member to the chair frame. An alternative embodiment discloses a modified link member which is adapted to create an interference engagement with the slide bracket (54) to augment the locking action of the arcuate cam surface (75) within the arcuate notch (76). <IMAGE>
Patent DE-69120527-D1 (DE)
Inventor: BARLOW YVONNE
IPC: C12N5/071
Filed: 1991-03-04
Granted: 1996-08-01
Abstract: A method for the in vitro cultivation of anchorage dependent mammalian cells which comprises containing a substrate with a culture medium comprising anchorage dependent mammalian cells wherein said substrate comprises a film of synthetic polymer material and which is hydrophobic, non-inhibitory to cell growth and non-cytotoxic. <IMAGE>
Patent DE-69125173-D1 (DE)
Inventor: DIFRANCESCO DAVID
IPC: G06T11/00
Filed: 1991-12-03
Granted: 1997-04-17
Abstract: A method of transformation of any random sample of a surface texture pattern into a replicatable unit for computer graphics applications that can join together without borders to cover any desired surface area. The present invention is particularly well suited for obtaining texture patterns from high resolution photographs of actual surfaces to be used in a "texture library" of realistic replicatable fill patterns. In the preferred embodiment, the invention provides a method for identifying and isolating discontinuities in a texture pattern. The invention facilitates the smoothing of the isolated border discontinuities to produce a transformed, borderless texture sample.
Patent DE-69201066-D1 (DE)
Inventor: OSAWA RYOICHI
IPC: C07H13/04
Filed: 1992-03-06
Granted: 1995-02-16
Abstract: An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis prodcuts of colominic aicd and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.
Patent DE-69202525-D1 (DE)
Inventor: FRANCIONI RENZO
IPC: B65G47/30
Filed: 1992-06-29
Granted: 1995-06-22
Abstract: The articles (B) in an input flow are diverted onto a certain number of superposed sliding planes (5, 6, 7). This is achieved by means of one or more wheels, the peripheries of which have segments (10, 11, 12) which are spaced from the axis of rotation (X9) of the wheels (9) by distances corresponding to the distances of the sliding planes from the axis of rotation (X9). Each article is thus transferred towards a respective sliding plane (5, 6, 7) by a gradual movement. An alignment conveyor (16) located further downstream vertically aligns groups of articles on the superposed sliding planes (5, 6, 7) to define the piles. The piles are formed as a result of the articles (B) which are on the upper sliding planes (6, 7) falling onto the article below. The piles are preferably formed immediately before they are inserted in their packages (F). <IMAGE>
Patent DE-69210800-D1 (DE)
Inventor: LE GLEOUR JEAN
IPC: A01J27/00
Filed: 1992-12-17
Granted: 1996-06-20
Abstract: The process for simultaneously smoking and forming consists in arranging the cheese (2) to be smoked and to be formed on a tray (3), in impregnating it with the smoking smoke (5) at a temperature of between 15 and 45 DEG C for the time necessary for deformation by flowing of the mass of cheese through the openings in the tray (3), then in returning it to the preservation temperature once the smoking and the desired forming have been obtained. The smoked cheeses thus obtained (8, 9) may be used as raclette cheeses. <IMAGE>
Patent DE-69214457-D1 (DE)
Inventor: IDRISS SAMIR
IPC: G01F11/04
Filed: 1992-08-10
Granted: 1996-11-14
Abstract: A fluid metering device useful in implantable drug delivery systems is coupled between a pressurized fluid source and an outlet conduit to provide discrete flow pulses at a predetermined rate. The metering device consists of a first movable member constrained within a housing and a second movable member retained in a cavity by the first. Alternate positioning of the first member simultaneously fills and empties the cavity in which the second resides, discharging fluid through the conduit. The first movable member can be a planar slider, an axially translatable cylinder or a rotatable cylinder. The second movable member may be a flat shuttle, a sliding bar or a diaphragm.
Patent DE-69215865-D1 (DE)
Inventor: MILLER STEVEN
IPC: C09K11/64
Filed: 1992-02-25
Granted: 1997-01-23
Abstract: The amount of ionizing radiation to which a thermoluminescent material has been exposed is determined by first cooling the thermoluminescent material and then optically stimulating the thermoluminescent material by exposure to light. Visible light emitted by the thermoluminescent material as it is allowed to warm up to room temperature is detected and counted. The thermoluminescent material may be annealed by exposure to ultraviolet light.
Patent DE-69218443-D1 (DE)
Inventor: PERSSON JOHNNY
IPC: B26D7/01
Filed: 1992-09-08
Granted: 1997-04-24
Abstract: The invention relates to a method and apparatus for punching register holes in sheets provided with adjustment marks. The apparatus comprises a punching table (1) having punches (27) and sensors (28) on the punching table, a vacuum table (25) being provided in the punching table substantially in the plane thereof, said vaccuum table being adjustable in two mutually perpendicular directions in the plane of the punching table and being rotatable about an axis perpendicular to said plane. Adjustment means for the adjustment of the vacuum table are operatively connected to the sensors to control the operation thereof via a microprocessor in dependence of the adjustment marks being sensed by the sensors. When the method is practised the sheet is attached by suction to the vacuum table, and this table and thus the sheet is positioned by the adjustment of the vacuum table, the positioning being controlled in dependence of the position of the adjustment marks being sensed. After positioning the sheet is punched, the sheet then being released from the vacuum table and removed from the punching table.
Patent DE-69220875-D1 (DE)
Inventor: TAI JIMMY J
IPC: C07D239/88
Filed: 1992-10-06
Granted: 1997-08-21
Abstract: 4-Haloquinazolines can be prepared by the halogenation of the corresponding 4-hydroxyquinazolines with a phosphoryl, thionyl or carbonyl halide in the presence of a catalytically effective amount of a N,N-dialkylformamide. The reaction is catalyzed by the addition of soluble organic halide salts.
Patent DE-69221926-D1 (DE)
Inventor: SEYMOUR PATRICIA ANN
IPC: A61K31/55
Filed: 1992-04-09
Granted: 1997-10-09
Abstract: Combinations having synergistic anxiolytic activity which comprise a first component selected from the group consisting of 8-hydroxy-2-(dipropylamino)-tetralin, gepirone, ipsapirone,tandospirone,(7S,9S)-2-(2-pyrimidyl)-7-(succinimidomethyl)p erhydro-1H-pyrido[1,2-a]pyrazine, or chlordiazepoxide; and a second component selected from the group consisting of 1-(2-pyrimidyl)pyrazine and idazoxan.
Patent DE-69224542-D1 (DE)
Inventor: RICHARD HERVE
IPC: A61K8/00
Filed: 1992-04-03
Granted: 1998-04-09
Abstract: Compound of formula:   <IMAGE> (I)  in which R1 is of the formula: <IMAGE> (II)  and R2 is a C8-C20 alkoxy or mono- or dialkylamino or is of the formula:   <IMAGE> (III)  where n=0 or 1; R4 denotes H, OH or C1-C6 alkoxy; R5 denoted H or COOR3 and R3 is a C4-C20 alkyl. Application of these compounds for the protection of the skin and hair against ultraviolet radiation.
Patent DE-69230917-D1 (DE)
Inventor: LESNIEWSKI R
IPC: C07K7/08
Filed: 1992-09-16
Granted: 2000-05-18
Abstract: The present invention provides an improved assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with at least one polypeptide containing at least one epitope of an HCV antigen. Preferred assay formats include a confirmatory assay, a combination assay, a synthetic polypeptide-based assay, an immunodot assay and a competition assay.
Patent DE-69300093-D1 (DE)
Inventor: MARIE BRUNO
IPC: B29C59/12
Filed: 1993-06-18
Granted: 1995-05-04
Abstract: The device comprises a tubular gas passage (5) formed between a peripheral electrode (1) and a dielectric tube (3), on the internal face of which is applied a second electrode (4), the gas moving transversely in the passage (5) between an extended inlet (7) and an extended outlet (8), which are opposite each other, and whose height does not exceed the radial thickness (e) of the passage (5). Application especially to the production of ozone or of treatment (processing) atmospheres. <IMAGE>
Patent DE-69303581-D1 (DE)
Inventor: COLOMBO ATTILIO
IPC: E06B3/90
Filed: 1993-11-12
Granted: 1996-08-14
Abstract: A revolving security door (1) for the controlled passage of persons from a non-protected environment (2) to a protected environment (3), for example a bank, which permits the normal transit of persons even in the event of the interception of an unwelcome person, including a cylindrical chamber (5) formed inside a structure (4), a turnstile (6) rotatable within the chamber (5) in a predetermined sense of rotation and having sectors (9) each for accommodating a person, an entry aperture (10) and an exit aperture (11) formed in the structure (4), a sensor (12) associated with the structure (4) for detecting an unwelcome person or object and for emitting an alarm signal, an emergency door (13) associated with the exit aperture (11) and activated to close by the said alarm signal, the said door (13) comprising a first panel (14) and a second panel (15) which are held together and made to rotate in the opposite sense of rotation from that of the turnstile (6), after the door (13) has been closed by the first panel (14) and before the door (13) is opened by the opening of both panels (14, 15). <IMAGE>
Patent DE-69308517-D1 (DE)
Inventor: FRANCOIS ALAIN
IPC: A47B45/00
Filed: 1993-12-13
Granted: 1997-04-10
Abstract: The invention relates to a display unit for a shelf comprising a base (1) intended to form a surface (A) on which objects of different widths may be placed. The base (1) is formed by a plurality of juxtaposed parts (2, 3, 4) and at least one sliding lip (11). Each part (2) has a first edge (5) and a second edge (6) which are so shaped as to enable them to accommodate the sliding lip (11). <IMAGE>
Patent DE-69313714-D1 (DE)
Inventor: FISCHELL ROBERT E
IPC: A61M25/02
Filed: 1993-04-21
Granted: 1997-10-16
Abstract: A blood containment arterial access device (10) is provided which includes a thin-walled tube (12) having a lumen (16) which extends from the distal end of the tube (12) to the proximal end of the tube (12). The device (10) includes a transparent viewing cylinder (14) having a proximal end and a distal end. The distal end of the viewing cylinder (14) forms a pressure tight seal with the tube (12) proximal end and further includes a lumen (18) in fluid communication with lumen (16) of tube (12). The viewing cylinder (14) forms an enclosed volume in order to contain blood that enters into the opening of the distal end of the tube (12). A guide wire access (22,24) is located at the proximal end of the viewing cylinder (14). The guide wire access (22,24) allows passage of a guide wire or catheter or other similar structure through the viewing cylinder (14) and into the thin-walled tube (12). The access (22,24) provides a pressure tight seal to prevent release of blood prior to insertion of the catheter or guide wire through the access mechanism (22,24). <IMAGE>
Patent DE-69321134-D1 (DE)
Inventor: GILBERT RICHARD JAMES
IPC: C12N15/57
Filed: 1993-10-28
Granted: 1998-10-22
Abstract: A plasminogen analogue activatable by thrombin to have plasmin activity which contains the cleavage site sequence P4-P3-Pro-Arg-P1'-P2' where P3 is a basic amino acid residue, P4 is a hydrophobic amino acid residue and each of P1' and P2' is independently a non-acidic amino acid residue, said site being cleavable by thrombin between Arg and P1'.
Patent DE-69329595-D1 (DE)
Inventor: HARRISON PHILIP GODFREY
IPC: E04B1/61
Filed: 1993-04-08
Granted: 2000-11-30
Abstract: A rectilinear composite building panel having a pair of opposed faces, and a pair of opposed sides, the panel comprising a pair of spaced-apart rigid face sheets (56), a rigid insulating material (58) sandwiched between, and adhering to, the face sheets, connecting means (60) connecting the face sheets together to resist relative movement between the face sheets in the plane of the panel and out of the plane of the panel; the opposed sides (66, 70) each have a profiled shape for mating with a correspondingly profiled side of an adjacent panel; each side (66, 70) has means (72, 74) for securing, or being secured to, a side of an adjacent panel of the same general construction. The panels can be easily assembled together to form a fire-resistant multi-storey building. <IMAGE>
Patent DE-69330672-D1 (DE)
Inventor: MAKINO YUJI
IPC: A61K9/48
Filed: 1993-06-11
Granted: 2001-10-04
Abstract: A pharmaceutical preparation for intra-airway administration, comprising a powdery preparation for intra-airway administration contained in a container made from a material mainly comprising at least one member selected from the group consisting of hydroxypropylmethylcellulose, methylcellulose, hydroxypropylcellulose, starch, hydroxypropylated starch and sodium alginate.
Patent DE-69330788-D1 (DE)
Inventor: MATSUO MASAAKI
IPC: A61P27/02
Filed: 1993-04-09
Granted: 2001-10-25
Abstract: Disclosed herein are compounds of the following formula:   <IMAGE>   wherein R1 is a group of the formula   <IMAGE>   "X" is CH2 or N, "Z" is O, S, or N-R6, "A" is an amino acid residue, and Y, R2, R3, R4, R5, R6, and R7 are substituent variables as defined herein. The compounds are antagonists of tachykinin, and as such are useful for alleviation of pain and for treatment of disorders including asthma, bronchitis, rhinitis, conjunctivitis, dermatitis, arthritis, and urticaria.
Patent DE-69331292-D1 (DE)
Inventor: YAMAMOTO IWAO
IPC: G06F9/445
Filed: 1993-01-22
Granted: 2002-01-24
Abstract: An electronic apparatus (10) which includes a CPU (1), a ROM (2), a RAM (3), an input port (4), a data bus (5), an address bus (6), a patching portion address register (7) and a patching interrupt vector register (8) which are connected to the data bus (5), a comparator (9) which compares a coincidence with the address stored in the address register (7) and an address on the address bus (6) and supplies an interrupt to an interrupt control portion of the CPU (1) which is also supplied with other interrupts for other processing. Further, an external storage device (20), connected to the input port (4), supplies a main program bug patching information which is stored in the RAM (3), which includes a stack area (32) in which there are saved data written in the address register (7) and the patching interrupt register (8), so that patching of program bugs can be carried out even during an interrupt. <IMAGE>
Patent DE-69331641-D1 (DE)
Inventor: BRAITHWAITE WILSON
IPC: A61M39/00
Filed: 1993-04-07
Granted: 2002-04-04
Abstract: PCT No. PCT/GB93/00734 Sec. 371 Date Dec. 21, 1994 Sec. 102(e) Date Dec. 21, 1994 PCT Filed Apr. 7, 1993 PCT Pub. No. WO93/19808 PCT Pub. Date Oct. 14, 1993A connecting device for connecting together two or more medical instruments so as to allow, or control, the flow of fluid between the various medical instruments. The connecting device includes an intermediate conduit element having two inlets, to which the medical instruments may be connected, along with fluid directing members located inside the intermediate conduit element and able to move linearly therein. The fluid directing members are able to restrict, or allow, the flow of fluid, by way of the intermediate conduit element, between two or more medical instruments when they are connected to the conduit element, depending on the linear position of the fluid directing member inside the intermediate conduit element.
Patent DE-69333371-D1 (DE)
Inventor: BOEHM MARCUS F
IPC: C07C69/76
Filed: 1993-04-22
Granted: 2004-01-29
Abstract: Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, and pyrrole derivatives. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.
Patent DE-69400949-D1 (DE)
Inventor: PAQUES GERARDUS HENRICUS FRANC
IPC: E04H7/30
Filed: 1994-08-05
Granted: 1997-01-02
Abstract: A method of and wall sheet for building up a silo with lining and a method of manufacturing wall sheets for such a silo. The wall sheets are pre-formed wall sheets, comprising a base sheet (1) and a sheet (4) of lining material, bonded thereto in a slightly staggered manner. The lining material covers a number of bolt holes (2,3) of the base sheet (1) and already fitted in the covered bolt holes are fastening means, secured against rotation and also covered by the lining material. After the wall sheet has been mounted, free edge strips of the layer of lining material fall over uncovered edge zones of adjacent wall sheets. Connecting sheets of lining material are welded together along the edges, and, if necessary, the overlapping strips are bonded to the subjacent wall sheets. <IMAGE>
Patent DE-69410596-D1 (DE)
Inventor: JEPHCOTT DAVID LYNTON
IPC: E04G5/10
Filed: 1994-02-04
Granted: 1998-07-02
Abstract: In the field of materials handling, e.g., in warehouses, there is a need for a low-cost shelving access system which does not require a user thereof to carry objects whilst negotiating, e.g., ladders and steps. The disclosure relates to an apparatus including a framework (11); a generally vertical ladder (12a, 12b) secured to the framework; and a goods hoist (20) secured to the framework in such a way that the platform (22a, 22b) of the goods hoist (20) may be manoeuvred to a plurality of locations adjacent the ladder (12a, 12b). The ladder (12a, 12b) is moveable laterally on the framework to enable the platform (22a, 22b) of the goods hoist to access any position within the envelope defined by the framework (11).
Patent DE-69410752-D1 (DE)
Inventor: INNIS CHARLES L JR
IPC: F16J15/32
Filed: 1994-10-18
Granted: 1998-07-09
Abstract: A rolling mill bearing assembly coolant guard, for sealing against ingress of coolant and entrained contaminants, comprises (a) a radial annular base flange with a planar rear face for securing against the non-rotatable flat mounting surface of the bearing assembly; (b) a circular sealing flange integrally joined to the inner edge of the base flange and extending angularly away from the base flange front face and across the gap, between the mounting surface and a roll end face, into sealing contact with the roll end face; and (c) a reinforcing device which accommodates flexible radial deformation of the coolant guard w.r.t. the roll neck axis, while resisting any axial distortion of the base flange away from the mounting surface, and which comprises a hoop embedded in the base flange, the hoop width extending parallel to the roll neck axis.
Patent DE-69412120-D1 (DE)
Inventor: CLOKIE CAMERON
IPC: A61L27/22
Filed: 1994-11-14
Granted: 1998-09-03
Abstract: A liquid composition comprising a transforming growth factor  beta  (TGF- beta ) in a liquid carrier which gels at about 37 DEG  C., promotes osseointegration of an implant in bone, when introduced into a bore in the bone, prior to insertion of the implant in the bone; a method of placing an implant in bone comprises injecting said liquid composition into a bore in the bone prior to insertion of the implant in the bore, the TGF- beta  being present in the liquid composition in a concentration effective in an interspace between an inner surface of the bore and an outer surface of the implant, to promote osseointegration.
Patent DE-69415684-D1 (DE)
Inventor: CLELAND JEFFREY
IPC: A61K9/00
Filed: 1994-10-13
Granted: 1999-02-11
Abstract: A method for drying microspheres in a fluidized bed is provided, along with a composition comprising microspheres dried by that method.