Patent SG-11201900789V-A (SG)
Title: Multivalent pneumococcal polysaccharide-protein conjugate composition
Inventor: AN KYUNGJUN
IPC: A61P37/04
Filed: 2017-08-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIPO I PCT °mons °nolo olioloio um mum oimiE (10) International Publication Number WO 2018/027123 Al (51) International Patent Classification: A61K 39/385 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61P 31/04 (2006.01) A61K 39/09 (2006.01) A61P 37/04 (2006.01) (21) International Application Number: PCT/US2017/045479 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/371,529 05 August 2016 (05.08.2016) US (71) Applicants: SANOFI PASTEUR, INC. [US/US]; 1 Dis- covery Drive, Swiftwater, PA 18730 (US). SK CHEMI- CALS CO., LTD. [KR/KR]; Life Science Biz, 310, Pangyo-ro, Seongnam-si, Gyeonggi-do, 13494 (KR). (72) Inventors: AN, Kyungjun; 302, 8-19, Bangbae-ro 20- gil, Seocho-gu, Seoul, 06664 (KR). CHOI, Wooyoung; 805-1703, 52, Pungdeokcheon-ro, Suji-gu, Yongin-si, Gyeonggi-do, 16843 (KR). HAM, Dongsoo; 113-505, 373, Gwongwang-ro, Paldal-gu, Suwon-shi, Gyeonggi-do, 16493 (KR). KIM, Hun; 6114-2903, 76, Central Town- ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16505 (KR). SHIN, Jinhwan; 233-1201, 24, Jungdae-ro, Songpa-gu, Seoul, 05834 (KR). HOPFER, Robert; C/o Sanofi Pas- teur, 1 Discovery Drive, Swiftwater, PA 18730 (US). KENSINGER, Richard, D.; C/o Sanofi Pasteur, 1 Dis- covery Drive, Swiftwater, PA 18730 (US). KYAW, Moe; C/o Sanofi Pasteur, 1 Discovery Drive, Swiftwater, PA 18730 (US). DESAUZIERS, Eric; C/o Sanofi Pasteur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). EL GUERCHE SEBLAIN, Clotilde; C/o Sanofi Pasteur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). TA- LAGA, Philippe; C/o Sanofi Pasteur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). (74) Agent: DONALDSON, Timothy, B.; MH2 Technology Law Group, 1951 Kidwell Drive, Suite 550, Tysons Corner, VA 22182 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: - with international search report (Art. 21(3)) (54) Title: MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION (57) : Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 16 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid or CRM19 7 , wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 22F, 23F, and 33F, wherein two of the capsular polysaccharides are conjugated to tetanus toxoid and the remaining capsular polysaccharides are conjugated to CRM197, and wherein the two capsular polysaccharides that are conjugated to tetanus toxoid are selected from the group consisting of serotypes 1, 3, and 5. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.