baber/WOPTO huggingface dataset:
Patent ES-2326116-T3 (ES)
Title: Procedimiento para determinar el nivel actual de un liquido en un recipiente.
Inventor: HUEMER HERFRIED
IPC: G01F23/16
Filed: 2003-04-24
Granted: 2009-10-01
Abstract: Procedimiento para envasar un líquido en un recipiente (1) de un analizador o para extraer un líquido del mismo y para determinar el nivel actual de relleno del líquido en este recipiente (1) mediante un tubo de inmersión (2) común que inmerge en el líquido del recipiente (1), efectuándose el envase o la extracción del líquido a través del tubo de inmersión (2) que está conectado a través de un sistema de tuberías (15) con un dispositivo de bombeo (5) y que puede alimentarse de un medio gaseiforme, preferentemente aire, efectuándose la determinación del nivel actual del líquido en este recipiente (1) por el hecho que la presión p en el sistema de tuberías (15), de acuerdo con la variación de la presión en función del tiempo, es medida por un sensor de presión (6) y aumentada a partir de la presión ambiente p0 hasta el punto en que, en una presión p1, una modificación de presión discontinua se produzca por la salida de la columna de líquido que se encuentra en el tubo de inmersión (2), determinándose la diferencia de presión entre la presión ambiente p 0 y la presión p 1 en la modificación de presión discontinua, o el tiempo t 1 hasta alcanzar dicha modificación de presión discontinua, y utilizándose dicha diferencia para calcular el nivel actual de relleno del recipiente (1).
Patent ES-2322572-T3 (ES)
Inventor: CATCHPOLE IAN RICHARD
IPC: A61K47/12
Filed: 2003-01-23
Granted: 2009-06-23
Abstract: The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which compromises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state (such as a glass).
Patent ES-2279113-T3 (ES)
Title: Compuestos tensioactivos no ionicos solubles en agua que contienen fluor, su utilizacion y procedimiento para la preparacion de los compuestos.
Inventor: NAGASHIMA KOUJI
IPC: C09D11/326
Filed: 2003-04-24
Granted: 2007-08-16
Abstract: Compuesto representado por la fórmula (1): W-CnF2n-X-(CH2CH2O)a-Y (1) en la que n es un entero de 2 a 6; W es un átomo de hidrógeno o un átomo de flúor; X es -COO-, -SO2-N(R)-, -M-O- o -CH2O-M-O- (en la que R es un grupo alquilo inferior; y M es un grupo alquileno sustituido opcionalmente con un grupo hidroxilo); a es un entero de 10 a 50; e Y es un grupo alquilo sustituido o no sustituido que presenta de 4 a 19 átomos de carbono, un grupo arilo sustituido o no sustituido, un grupo acilo, un grupo alquenilo, un grupo alquinilo, -M'' -CmF2m-W'' o -M'' -OCH2-CmF2m-W'' (en la que m es un entero de 2 a 6; W'' es un átomo de hidrógeno o un átomo de flúor; y M'' es un grupo alquileno sustituido opcionalmente con un grupo hidroxilo); estando la proporción de peso molecular (MWEO) del grupo polioxietileno (la fracción (CH2CH2O)a) al peso molecular (MWF) de los grupos fluoroalquilos (las fracciones W-CnF2n y CmF2m-W'') dentro del intervalo expresado por la ecuación: MWEO/MWF = 2, 2 a 10; y presentando el compuesto un valor de HLB de Griffin de 10 a 16.
Patent ES-2538805-T3 (ES)
Title: Unidad de pista de exposición ajustable en profundidad y anchura con separaciones desmontables
Inventor: JAY RICHARD
IPC: A47F1/12
Filed: 2003-03-28
Granted: 2015-06-24
Abstract: Una pista de exposición moldeada integralmente (12, 12', 50, 165) desprovista de paredes laterales moldeadas integralmente que se alcen verticales desde la misma, que comprende: (a) unos extremos opuestos delantero y trasero, (b) una pluralidad de nervios (92) separados lateralmente y que se extienden longitudinalmente, conectados a dichos extremos delantero y trasero con una ranura longitudinal definida entre cada dos nervios adyacentes, teniendo dichos nervios unas superficies superiores que definen un plano superior de dicha pista a un primer nivel para soportar productos para que se deslicen sobre las mismas, y unas superficies inferiores que definen un segundo nivel por debajo de dicho primer nivel, (c) un par de soportes marginales laterales opuestos (93, 94) conectados a dichos extremos delantero y trasero, teniendo dichos soportes marginales laterales unas superficies inferiores a un tercer nivel por debajo de dicho segundo nivel, y (d) una pluralidad de vigas separadas longitudinalmente (95) que se extienden transversalmente entre dichos soportes marginales laterales y que intersecan y unen dichos nervios, caracterizada por que dichas vigas tienen unas superficies superiores a un cuarto nivel por debajo de dicho primer nivel y tienen unas superficies inferiores, definiendo dichos soportes marginales laterales, paredes delantera y trasera y superficies inferiores de dichos nervios una base en la que dichas superficies inferiores de dichos nervios y dichas superficies inferiores de dichas vigas definen un techo discontinuo de dicha base, y por que la pista de exposición puede colocarse sobre un estante de góndola inclinado (166), en la que dicha pista de exposición comprende adicionalmente en su extremo posterior unos medios de enganche posteriores para acoplar de manera desmontable dicha pista de exposición a dicho estante de góndola, y estando configurados dichos medios de enganche posteriores para recibir un pasador (168) acoplado a dicha pista y dicha góndola.
Patent ES-2369077-T3 (ES)
Title: Nuevo procedimiento y composición para producir una vacuna alogénica celular.
Inventor: KARLSSON-PARRA ALEX
IPC: C12N5/0786
Filed: 2003-06-05
Granted: 2011-11-25
Abstract: Composición que comprende una célula presentadora de antígeno (APC), aislada de un sujeto, o establecida y/o aislada de una línea celular de leucemia mieloide, y modificada con un antígeno utilizando pulsos, transfección, infección o fusión y se trata con un agente capaz de eliminar ácido siálico en la superficie de dicha APC, para su uso como una vacuna alogénica celular en un sujeto incompatible al MHC.
Patent ES-2288609-T3 (ES)
Inventor: CHAPLIN PAUL
IPC: A61K39/00
Filed: 2003-04-16
Granted: 2008-01-16
Abstract: The invention concern the use of a virus for the preparation of a medicament for the vaccination or treatment of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus is preferably a Modified Vaccinia Virus Ankara.  In particular, the invention concerns the vaccination of neonates against infections with viruses belonging the same virus group than the virus used for vaccination. Moreover, the invention concerns the vaccination of neonates against antigens selected from foreign antigens and tumour antigens, wherein the tumour antigen and/or the foreign antigen are different from the antigens associated with the virus. The invention further concerns the use of viruses as defined above to increase the level of factors which activate dendritic cells or their precursor cells and/or to increase the number of dendritic cells or their precursor cells and/or to increase the production and/or cellular content of an interferon (IFN) or IL-12.
Patent ES-2285129-T3 (ES)
Inventor: HAGGANDER JAN
IPC: F02K9/97
Filed: 2003-05-28
Granted: 2007-11-16
Abstract: A wall structure (2) and components incorporating such a wall structure that are intended to be exposed to high thermal loads. The wall structure (2) includes at least two layers; a first layer (5) and a second layer (6), the second layer (6) being located closer to a source of the thermal load than the first layer (5). The layers (5, 6) are arranged so that heat is allowed to be conducted from the second layer (6) to the first layer (5). Each of the first and second layers (5, 6) are adapted to carry a significant portion of a structural load, and the second layer (6) exhibits a higher thermal conductivity and/or a lower thermal expansion than the first layer (5) which reduces thermal strain in the wall structure (2).
Patent ES-2315538-T3 (ES)
Title: Composicion para el cuidado de tejidos.
Inventor: FERGUSON PAUL
IPC: C08G81/02
Filed: 2003-11-28
Granted: 2009-04-01
Abstract: Un procedimiento para la preparación de partículas de látex injertadas con polisacárido, en el que el polisacárido tiene enlaces a-1,4, consistiendo el proceso de producción en polimerización de emulsión de núcleo/cubierta, y siendo las partículas de látex derivadas de monómeros de látex, en el que se permite que entre el 50% y el 99,9% en peso de monómero de látex polimerice con anterioridad a la adición del polisacárido.
Patent ES-2285227-T3 (ES)
Inventor: AICHER THOMAS DANIEL
IPC: C07D513/04
Filed: 2003-07-28
Granted: 2007-11-16
Abstract: Described herein are compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, S, and O; Alk is (C<SUB>1-4</SUB>) alkylene or hydroxy substituted (C<SUB>1-4</SUB>) alkylene; X is oxygen or sulfur; R<SUP>1 </SUP>is hydrogen, (C<SUB>1-6</SUB>) fluroalkyl, (C<SUB>3-6</SUB>) cycloalkyl, or (C<SUB>1-4</SUB>) alkyl, wherein the (C<SUB>1-4</SUB>) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCH<SUB>2</SUB>CH<SUB>2</SUB>OH, or -CN; R<SUP>2 </SUP>is H, halogen, (C<SUB>1-6</SUB>) fluoroalkyl, (C<SUB>1-6</SUB>) cycloalkyl, OR<SUP>4</SUP>, SR<SUP>4</SUP>, NO<SUB>2</SUB>, CN, COR<SUP>4</SUP>, C(O)OR<SUP>4</SUP>, CONR<SUP>5</SUP>R<SUP>6</SUP>, NR<SUP>5</SUP>R<SUP>6</SUP>, SO<SUB>2</SUB>NR<SUP>5</SUP>R<SUP>6</SUP>, NR<SUP>5</SUP>COR<SUP>4</SUP>, NR<SUP>5</SUP>SO<SUB>2</SUB>R<SUP>4</SUP>, optionally substituted aromatic, or (C<SUB>1-6</SUB>) alkyl, wherein (C<SUB>1-6</SUB>) alkyl is unsubstituted or substituted with a hydroxy group; R<SUP>3 </SUP>is hydrogen (C<SUB>1-6</SUB>) fluoroalkyl, (C<SUB>2-6</SUB>) alkenyl, Ar, (C<SUB>1-4</SUB>)alkyl-Ar, or (C<SUB>1-4</SUB>) alkyl wherein (C<SUB>1-4</SUB>) alkyly is unsubstituted or substituted with a phenyl; R<SUP>4 </SUP>is hydrogen, (C<SUB>1-6</SUB>) alkyl, (C<SUB>1-6</SUB>) fluoroalkyl, or optionally substituted aromatic; R<SUP>5 </SUP>and R<SUP>6 </SUP>are independently hydrogen, (C<SUB>1-6</SUB>) alkyl, or optionally substituted aromatic, R<SUP>7 </SUP>is hydrogen, (C<SUB>1-6</SUB>) alkyl, (C<SUB>1-6</SUB>) fluoroalkyl, or optionally substituted aromatic; R<SUP>8 </SUP>and R<SUP>9 </SUP>are independently hydrogen, (C<SUB>1-6</SUB>) alkyl, or optionally substituted aromatic; Ar is optionally substituted phenyl, napthyl, monocyclic heteroaromatic or bicyclic heteroaromatic; Z<SUP>1 </SUP>and Z<SUP>2 </SUP>are independently selected from hydrogen, halogen, (C<SUB>1-6</SUB>) alkyl, (C<SUB>1-6</SUB>) fluoroalkyl, OR<SUP>7</SUP>, SR<SUP>7</SUP>, NO<SUP>2</SUP>, CN, COR<SUP>7</SUP>, CONR<SUP>8</SUP>R<SUP>9</SUP>, NR<SUP>8</SUP>R<SUP>9</SUP>, and optionally substituted aromatic; and all salts, solvates, optical and geometric isomers, and crystalline forms thereof. Also, described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I)
Patent ES-2297282-T3 (ES)
Inventor: WILDE EUGEN
IPC: H05B3/74
Filed: 2004-01-16
Granted: 2008-05-01
Abstract: Heating unit (11), especially for a cooker with a glass-ceramic hob, is divided into at least two heating regions (17, 19; 21). The first area is protected by a first excess-temperature fuse (13) and has a maximum power output, while the second region is not monitored by the excess-temperature fuse and has a maximum power output of approximately 2.5 W per cm2>.
Patent ES-2283947-T3 (ES)
Inventor: WILKINS PETER RAVENSCROFT
IPC: G05D23/00
Filed: 2004-06-10
Granted: 2007-11-01
Abstract: Apparatus and a method are provided for detecting an abnormal rise in temperature associated with a combination of a cooking utensil (10) and a cooking zone (8) of a cooking surface (4) overlying an electric heater (6). The apparatus has a first temperature-responsive device (24) is provided within the heater and adapted to monitor temperature of the cooking surface (4). A second temperature-responsive device (26) is provided within the heater and adapted to monitor temperature of the cooking utensil (10) through the cooking surface (4) to provide an electrical output as a function of temperature of the cooking utensil. Means (28) is provided for calculating first and second derivatives (D1, D2) with time of the temperature sensed by the second temperature-responsive device (26) over an operating temperature range of the heater. Means (28) is provided to determine stabilisation of the first derivative (D1) within stabilising threshold limit values. Means (28) is provided to thereafter compare the first and second derivatives (D1, D2) with first and second predetermined threshold values and to detect an abnormal rise in temperature when the first and second predetermined threshold values are exceeded. <IMAGE>
Patent ES-2268636-T3 (ES)
Inventor: SCHOCKE KAI-OLIVER
IPC: C08K5/3492
Filed: 2004-03-02
Granted: 2007-03-16
Abstract: The present invention relates to tanning aids, comprises a polymethyl methacrylate shaped body, where the transparency of the polymethyl methacrylate shaped body at 380 nm is at least 40%, and the polymethyl methacrylate shaped body comprises 0.005 to 0.1% by weight, based on the weight of the polymethyl methacrylate shaped body, of at least one triazine compound according to formula (I) in which R is halogen, C<SUB>1</SUB>-C<SUB>22</SUB>-alkyl, C<SUB>1</SUB>-C<SUB>22</SUB>-alkoxy, C<SUB>I</SUB>-C<SUB>22</SUB>-hydroxyalkoxy, C<SUB>I</SUB>-C<SUB>22</SUB>-alkoxyalkyl, -NHR<SUB>1</SUB>-, -N(R<SUP>1</SUP>)<SUB>2</SUB>, or a radical of the formula (Ia) X<SUP>1</SUP>, X<SUP>2 </SUP>and X<SUP>3</SUP>, independently of one another, are -CONHR<SUP>1</SUP>, -NR<SUP>2</SUP>R<SUP>3</SUP>, -SO<SUB>2</SUB>R<SUP>4</SUP>, -CN, -COR<SUP>5 </SUP>or -COOR<SUP>6</SUP>, R<SUP>1 </SUP>is hydrogen, C<SUB>1</SUB>-C<SUB>22</SUB>-alkyl, C<SUB>6</SUB>-C<SUB>20</SUB>-aryl, C<SUB>7</SUB>-C<SUB>20</SUB>-aralkyl, C<SUB>5</SUB>-C<SUB>8</SUB>-cycloalkyl, or a radical of the formula (Ib) in which A<SUB>1 </SUB>is C<SUB>I</SUB>-C<SUB>8</SUB>-alkyl, C<SUB>5</SUB>-C<SUB>6</SUB>-cycloalkyl, C<SUB>6</SUB>-C<SUB>20</SUB>-aryl, C<SUB>7</SUB>-C<SUB>20</SUB>-aralkyl; and m<SUB>1 </SUB>is 1 to 10, R<SUP>2 </SUP>and R<SUP>3</SUP>, independently of one another, are hydrogen, C<SUB>I</SUB>-C<SUB>22</SUB>-alkyl, C<SUB>6</SUB>-C<SUB>8</SUB>-cycloalkyl, C<SUB>6</SUB>-C<SUB>20</SUB>-aryl, C<SUB>7</SUB>-C<SUB>20</SUB>-aralkyl, a radical of the formula (Ib) or a radical of the formula -COR<SUP>1</SUP>; R<SUP>4 </SUP>is hydrogen, C<SUB>I</SUB>-C<SUB>22</SUB>-alkyl, C<SUB>6</SUB>-C<SUB>8</SUB>-cycloalkyl, C<SUB>6</SUB>-C<SUB>20</SUB>-aryl, C<SUB>7</SUB>-C<SUB>20</SUB>-aralkyl, a radical of the formula (Ib) or a radical of the formula -NR<SUP>2</SUP>R<SUP>3</SUP>; R<SUP>5 </SUP>and R<SUP>6</SUP>, independently of one another, are hydrogen, C<SUB>I</SUB>-C<SUB>22</SUB>-alkyl, C<SUB>6</SUB>-C<SUB>8</SUB>-cycloalkyl, C<SUB>6</SUB>-C<SUB>20</SUB>-aryl, C<SUB>7</SUB>-C<SUB>20</SUB>-aralkyl or a radical of the formula (Ib); X<SUP>4</SUP>, X<SUP>5 </SUP>and X<SUP>6</SUP>, independently of one another, are hydrogen or hydroxyl.
Patent ES-2313019-T3 (ES)
Inventor: DILLON MICHAEL PATRICK
IPC: A61P13/00
Filed: 2004-04-30
Granted: 2009-03-01
Abstract: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein m, A, X, Y, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4 </SUP>and R<SUP>5 </SUP>are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
Patent ES-2375935-T3 (ES)
Inventor: MERCADAL MATHIEU
IPC: H04N7/18
Filed: 2004-01-16
Granted: 2012-03-07
Abstract: A method and system for maintaining the line of sight of an airborne camera fixed on a target by compensating for overflight velocity of the aircraft. The compensation system automatically commands an angular velocity of the line of sight to maintain the camera pointing at the target being overflown. This angular velocity of the line of sight is computed based upon the aircraft overflight velocity and upon a vector from the aircraft to the target. This automatic compensation for aircraft overflight velocity causes the line of sight to remain fixed upon the target. The compensation system drives a gimbal system upon which the camera is mounted to perform this compensation automatically.
Patent ES-2340856-T3 (ES)
Title: Instrumento de escritura con chorro de liquido.
Inventor: BICH XAVIER
IPC: B43L19/00
Filed: 2004-12-16
Granted: 2010-06-10
Abstract: Instrumento de escritura con chorro de líquido, que comprende un elemento (2) sensiblemente tubular que se extiende entre un primer extremo (2a) y un segundo extremo (2b) y que está destinado a ser agarrado con la mano por un usuario, comprendiendo dicho elemento (2) tubular: - un depósito (3) de líquido, - un sistema (4) de proyección de líquido que comprende una cabeza (41) de proyección de líquido conectada al depósito (3) de líquido, estando destinada la cabeza (41) de proyección a proyectar a distancia el líquido sobre un soporte (8), - una unidad (6) de tratamiento destinada a activar el sistema (4) de proyección de líquido para permitir a la cabeza (41) de proyección que proyecte a distancia el líquido sobre el soporte (8), - medios (12) de control de la distancia entre la cabeza (41) de proyección y el soporte (8), estando conectados los medios (12) de control a la unidad (6) de tratamiento, - medios (14; 13, 6) de detección de movimiento de la cabeza (41) de proyección, estando conectados los medios (14; 13, 6) de detección de movimiento a la unidad (6) de tratamiento, estando adaptada la unidad (6) de tratamiento para ordenar la activación del sistema (4) de proyección de líquido cuando al menos los medios (12) de control determinan que la distancia entre la cabeza (41) de proyección y el soporte (8) es apropiada, caracterizado porque la unidad (6) de tratamiento está adaptada para hacer variar la frecuencia y/o la amplitud de señales eléctricas que ordenan la activación del sistema (4) de proyección de líquido de manera proporcional al movimiento detectado por los medios (14; 13, 6) de detección de movimiento, porque los medios de detección de movimiento están formados por un acelerómetro, y porque los medios (12) de control están formados por medios (12) de medición para medir la distancia entre la cabeza (41) de proyección y el soporte (8), y la unidad (6) de tratamiento está adaptada para ordenar la activación del sistema (4) de proyección de líquido cuando, por una parte, los medios (12) de medición determinan que la distancia entre la cabeza (41) de proyección y el soporte (8) es inferior a un valor máximo predeterminado, y por otra parte, los medios (14; 13, 6) de detección de movimiento detectan un movimiento.
Patent ES-2347049-T3 (ES)
Inventor: REINHARDT HOLGER
IPC: A61F13/00
Filed: 2005-08-23
Granted: 2010-10-25
Abstract: A bandage (1) is of elastic textile material and provided with a pad covered by an overlay (6) of identical or similar textile material and being attached to the textile material of the bandage by edges (3, 4) protruding from the pad, the overlay covering the pad is provided on its side facing the joint with knobs (7) of anti-slip material.
Patent ES-2389555-T3 (ES)
Inventor: VUKICEVIC SLOBODAN
IPC: A61K38/22
Filed: 1999-07-30
Granted: 2012-10-29
Abstract: Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal
Patent ES-2325623-T3 (ES)
Inventor: CHRISTEL RALF
IPC: B41F7/04
Filed: 2002-04-06
Granted: 2009-09-10
Abstract: The offset printer has one or more printing station with a transfer cylinder (03,07) on either side of the paper. Each transfer cylinder has a printing cylinder (02,11) in contact with it. The printing cylinders may have thin aluminum printing plates wrapped around them, with their edges held by clamps in longitudinal grooves (4) in their cylindrical surfaces. The transfer cylinders may have blankets with their ends held in longitudinal grooves (6). The grooves in the cylinders are broken up into staggered sections. The cylinders are all the same diameter which corresponds to the length of each section of paper to be printed.
Patent ES-2356740-T3 (ES)
Inventor: GUERET JEAN-LOUIS
IPC: A61K8/02
Filed: 2005-02-15
Granted: 2011-04-12
Abstract: A treatment kit comprises a composite structure capable of being made electroconductive and comprising an active substance intended to exercise and effect on the zone to be treated and an electric exciter comprising two electrodes consolidated into a graspable object allowing them to be contacted simultaneously with an exterior face of the composite structure to pass an electric current into it. A treatment kit comprises a composite structure capable of being made electroconductive and comprising an active substance intended to exercise and effect on the zone to be treated and an electric exciter comprising two electrodes consolidated into a graspable object allowing them to be contacted simultaneously with an exterior face of the composite structure to pass an electric current into it. The electric exciter and composite structure are so organized that the electrode can contact the structure without significant contact with the active substance. The composite structure is a patch, mask or towel. Independent claims are included for (1) an electric exciter comprising a battery or storage battery and a head which can be solidarized rigidly with them holding two electrodes, immobile with respect to one another, which can be simultaneously contacted with a composite structure; (2) a electric exciter additionally comprising a means of vibrating the electrodes controlled by a selector; (3) a method of cosmetic treatment of a zone of the skin comprising application of the composite structure to the skin and contacting it with the electric exciter.
Patent ES-2345260-T3 (ES)
Inventor: YOUNG DAVID S F
IPC: C12Q1/68
Filed: 2005-02-28
Granted: 2010-09-20
Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.