Patent SG-11201809470R-A (SG)
Title: Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
Inventor: BEDDIES GERALD
IPC: C07D401/12
Filed: 2017-05-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111110 11111110 11E111110 DOH 11111111111111110 11111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....o-\"\" WO 2017/207481 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, C07D 401/12 (2006.01) A61P 11/00 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, A61K 31/4412 (2006.01) A61P 19/00 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, A61K 31/4439 (2006.01) A61P 15/00 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, A61P 1/00 (2006.01) A61P 37/00 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (21) International Application Number: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. PCT/EP2017/062876 (84) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of regional protection available): ARIPO (BW, GH, 29 May 2017 (29.05.2017) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (25) Filing Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (26) Publication Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (30) Priority Data: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 16172544.5 01 June 2016 (01.06.2016) EP KM, ML, MR, NE, SN, TD, TG). (71) Applicants: BAYER ANIMAL HEALTH GMBH Declarations under Rule 4.17: [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen _ as to applicant's entitlement to apply for and be granted a (DE). BAYER PHARMA AKTIENGESELLSCHAFT patent (Rule 4.1700) [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). — Published: (72) Inventors: BEDDIES, Gerald; Ringstr. 172, 51371 Lev- — with international search report (Art. 21(3)) = erkusen (DE). FOSTER, Adrian; 9, Eastry Park, Eastry Sandwich, CT130JL (GB). BOTHE, Ulrich; Kavalierstr. =_ 15, 13187 Berlin (DE). SCHMIDT, Nicole; 455 Mission Bay Blvd., San Francisco, CA 94158-0000 (US). BOMER, = Ulf; Leipziger Str. 49, 16548 Glienicke (DE). NUBBE- - MEYER, Reinhard; Moorweg 96, 13509 Berlin (DE). _ MOTTIER, Maria De Lourdes; Hover Feld 5, 40764 Lan- - = genfeld (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). = = (81) Designated States (unless otherwise indicated, for every = = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = (54) Title: SUBSTITUTED INDAZOLES UEFUL FOR TREATMENT AND PREVENTION OF ALLERGIC AND/OR INFLAM- MATORY DISEASES IN ANIMALS = = 8000 LPS + Example Compound 12 a — c a. 6000 1-1 0- as .c 4001 .4 To Il 2000 GC Z 1 1' I— 0 Nil N & \ \ ' & ,„ \ . a M ..7 IN cc' \-\\" < 0 \-V r; 7 © g cb cb cb A A b col re'' N• e' e' e; e' ce e; et e' rig•I ei \).- c h N c h N °) N `b \ IN 1 1 (57) : The present application relates to the use of substituted indazoles for treatment and/or prophylaxis of allergic and/or 0 el inflammatory diseases in animals, especially for treatment and/or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflam- matory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, 0 respiratory disease, mastitis and endometritis in animals.