baber/WOPTO huggingface dataset:
Patent CA-2404371-C (CA)
Inventor: FAUL PATRICK
IPC: B65B51/10
Filed: 2001-04-05
Granted: 2007-12-04
Abstract: The invention concerns an ultrasonic device for sealing at least two superimposed sheets, said device comprising a sealing assembly consisting of two elements which are respectively an anvil and a sonotrode, arranged opposite each other so that their facing surfaces form an interstice for passing through the sheets to be sealed, said interstice having an inlet section and an outlet section, the sonotrode vibrating at high frequencies to emit ultrasonic waves, characterised in that means are provided for generating between the superimposed sheets and said sealing assembly a relative movement along a specific feeding direction relative to the sealing assembly, and the section of said passage interstice decreases between its inlet section and its outlet section, and at least one element of said sealing assembly comprises a projecting ridge emerging into said passage interstice and extending along a direction globally parallel to said feeding direction. The invention also concerns a related method for sealing flexible packages, and the resulting packages.
Patent CA-2409912-C (CA)
Title: Improvements in grounding and thermal dissipation for integrated circuit packages
Inventor: DANOVITCH DAVID
IPC: H01L23/36
Filed: 2002-10-25
Granted: 2008-04-01
Abstract: In assembling a typical microelectronic chip package for which grounding and thermal dissipation is desired, when attempting to simultaneously attach a cover to two different surfaces with two different adhesives, difficulties are typically encountered. This invention provides for a method and electronic package to overcome these difficulties. A cover has an opening which is aligned with a contact on the substrate connected to ground potential. The cover is connected to the electronic device and the ground contact.
Patent CA-2415849-C (CA)
Inventor: GOEDE JOACHIM
IPC: A61K9/72
Filed: 2003-01-08
Granted: 2008-03-18
Abstract: To improve administration of powdered pharmaceuticals, a pharmaceutical powder cartridge (1) for powder inhalers for holding a pharmaceutical depot for a large number of pharmaceutical powder doses is proposed, having at least one storage space (6) and an integrated metering device, said integrated metering device comprising at least one metering slide (9, 13, 14) which can be moved approximately transversely in a metering slide channel (12) at least from a filling position to an emptying position, approximately transversely with respect to the direction of flow of the pharmaceutical powder out from the at least one storage space (6), said metering slide channel (12) with the at least one metering slide (9, 13, 14) being sealed off from the environment at least in the filling position of the metering slide (9, 13, 14), and also further measures and a corresponding inhaler.
Patent CA-2416761-C (CA)
Inventor: KOSMATOPOULOS KOSTAS
IPC: C07K14/71
Filed: 2001-07-20
Granted: 2013-04-23
Abstract: Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified. Independent claims are also included for the following: (1) immunogenic peptide epitopes (IIa) derived from (I) identified this way; and (2) nucleic acid (III) that encodes chimeric polypeptides (IV) containing one or more, same or different, copies of (IIa).
Patent CA-2419486-C (CA)
Inventor: FITZEMEYER MICHAEL
IPC: F24D3/14
Filed: 2001-08-15
Granted: 2005-06-21
Abstract: A mounting plate for securing the heating pipe of a radiant heat system to t he subfloor. The plate is a flat sheet with a groove (16) in the upper surface and a plurality of legs (14) underneath. The plate is composed of a rigid an d highly heat-conductive material, preferably aluminum and aluminum alloys. Th e legs form large air gaps which can be left empty or filled with insulation t o raise the efficiency of the system. The groove runs from one edge of the pla te to another. The bottom of the groove is preferably semicircular, with a diameter the same as the outside diameter of the pipe (20) so that heat tranfer is maximized. The pipe is retained in the groove by a ridge running the length of the groove or by forming the groove in an omega shape so that the pipe must be snapped into the groove.
Patent CA-2424227-C (CA)
Inventor: CHIANG HERMAN
IPC: A63B33/00
Filed: 2003-04-02
Granted: 2008-10-14
Abstract: A pair of swimming goggles of the present invention comprises a pair of left and right lens frames which respectively include an outer surface and an inner surface and receive a pair of lenses, a bridge member disposed at the upper edges of the inner sides of the left and right lens frames, and a head strap mews disposed at the outer sides of the left and right lens frames. The feature of the present invention is that the head strap means at least includes a first thread, a second thread, and a pair of adjustment fasteners disposed at the first and second threads, wherein the first thread is disposed at the upper position of the outer sides of the left and right frames, and the second thread is disposed at the lower position of the outer sides of the left and right frames. Thus, the adjustment fasteners properly adjust the first and second threads thereby providing different application lengths for the first and second threads and providing a desired pull force such that the upper and lower edges of the lens frames are adjusted to comfortably contact with the periphery of the eye holes and a desired refraction effect of the lenses in water is achieved.
Patent CA-2429354-C (CA)
Inventor: BRANDT KENNETH A
IPC: E02F9/22
Filed: 2001-12-05
Granted: 2009-11-24
Abstract: A user input device in accordance with one features of the present invention includes one or more joysticks (102, 104), movable by a user in an operator compartment of a power machine (10). The joysticks (102, 104) control direction of movement of the power machine (10), as well as travel speed.
Patent CA-2429409-C (CA)
Title: Apparatus and method for measuring drop size in an intravenous drip chamber
Inventor: BARNES C WILLIAM
IPC: A61M5/14
Filed: 2001-11-20
Granted: 2007-01-16
Abstract: A capacitive-based apparatus (10) for measuring the volume of a fluid drop (30) passing through an intravenous drip chamber (12). The apparatus include s a capacitor (16) comprising two parallel plates (42) that are a fixed distan ce apart and are positioned such that the fluid flow path in the drip chamber i s between them. The fluid drop moving through the drip chamber between the plates causes the capacitance of the plates to change. This change in capacitance is measured and from it, the volume of the drop is calculated. T he volumes of a series of drops are integrated to provide a measured rate of fl ow through the drip chamber. This measured rate of flow is compared to the programmed rate of flow and the difference is used to adjust a flow control device to obtain the desired rate of flow.
Patent CA-2440978-C (CA)
Title: La myeloperoxydase : un indicateur de risque des maladies cardio-vasculaires
Inventor: HAZEN STANLEY
IPC: G16H50/30
Filed: 2002-01-02
Granted: 2013-04-02
Abstract: L'invention porte sur des tests diagnostiques permettant d'évaluer le risque, chez un individu, de développer ou de contracter une maladie cardio-vasculaire. Selon un mode de réalisation, ce test diagnostique consiste à déterminer le niveau d'activité de la myéloperoxydase (MPO) dans un échantillon corporel prélevé sur un individu ou un sujet d'expérience. Selon un autre mode de réalisation, le test diagnostique consiste à déterminer le niveau de masse DE LA MPO dans un échantillon corporel prélevé sur le sujet d'expérience. Selon un autre mode de réalisation, le test diagnostique consiste à déterminer le niveau d'un ou plusieurs produits d'oxydation générés par la MPO sélectionnés dans un échantillon corporel prélevé sur le même sujet. Ces produits sélectionnés sont de la dityrosine, de la nitrotyrosine, de la méthionine sulfoxyde ou des produits de péroxydation lipidique générés par la MPO. Les niveaux d'activité de la MPO, de masse de la MPO, ou des produits d'oxydation générés par la MPO sélectionnés dans des échantillons corporels prélevés sur ledit sujet d'expérience sont ensuite comparés à une valeur prédéterminée obtenue à partir des mesures de l'activité de la MPO, de la masse de la MPO, ou des produits d'oxydation sélectionnés générés par la MPO, dans des échantillons corporels comparables prélevés sur l'ensemble de la population ou une population choisie de sujets humains. De telles comparaisons permettent d'évaluer le risque, chez un individu, de développer des maladies cardio-vasculaires.
Patent CA-2443774-C (CA)
Title: Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation
Inventor: CHRISTIAN SAMUEL T
IPC: A61P25/16
Filed: 2001-04-12
Granted: 2009-11-24
Abstract: Hydrophilic transportable N-linked glycosyl dopaminergic prodrug compounds according to FORMULA V, (see formula V) wherein, Ring 1 comprises a cyclic or heterocyclic ring, or aryl or heteroaryl ring, all of said rings comprising 4 to 8 carbon atoms, among which atoms are counted "X"  and "Y"; R0, R1, R2, R3 and R4 comprise substituents of Ring 1; either of X or Y is optional; each of X and Y, when present comprise a carbon atom, a halogen atom or a lower alkyl; Z, R5 and R5' are optional; when Z is present it comprises a lower alkyl having substituents R5, R5'; R6 and R6' comprise substituents on a carbon atom linking Z  with N through a single bond, or when Z is absent, linking N with Ring 1; N  comprises a nitrogen atom of an amine or an amide linked with E through a single bond and having R7 as a substituent; and E comprises a saccharide.
Patent CA-2446634-C (CA)
Title: Zinc diacrylate predispersed in high-cis polybutadiene
Inventor: JOHANSSON ANDERS H
IPC: B29K9/00
Filed: 2003-10-23
Granted: 2012-07-24
Abstract: The present invention provides a method and product that provides a dust-free homogeneous dispersion of zinc diacrylate in polybutadiene for use in golf balls. More specifically, the invention relates to a dispersion of zinc diacrylate in a special high-cis grade of polybutadiene commonly used by golf ball manufacturers. We have found that such a dispersion of ZDA can be made by using specific processing promoters, which not only allow the manufacture of the predispersion, but have a beneficial effect on the final properties of the golf ball. The processing promoters of the present invention enable more uniform dispersion of the ZDA into the polymer matrix, eliminate sticking to the mixer rotors, provide improved extrusion and pelletizing rates, as well as function as a separant to greatly minimize, if not totally eliminate, massing of the palletized product. This dust-free palletized product, which can optionally be supplied in slab form, is then sold to the golf ball manufacturer for direct addition to his mixer. The presence of the processing promoter also assists in the mixing of the product into the final golf ball compound as well as improve down-stream processing, such as extruding.
Patent CA-2450691-C (CA)
Inventor: ZAZOPOULOS EMMANUEL
IPC: C12N9/02
Filed: 2002-12-24
Granted: 2009-05-26
Abstract: Genes and proteins involved in the biosynthesis of lipopeptides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the A54145 lipopeptide from Streptomyces fradiae and the A54145-like lipopeptide from Streptomyces refuineus. These nucleic acids can be used to make expression constructs and transformed host cells for the production of lipopeptides. The genes and proteins allow direct manipulation of lipopeptides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of A54145.
Patent CA-2466201-C (CA)
Title: Nanostructured compositions
Inventor: BROTZMAN RICHARD W JR
IPC: C08J5/18
Filed: 2002-11-04
Granted: 2009-02-03
Abstract: A material composition made of a matrix material, a nano-sized particulate fraction and a micron-sized particulate fraction. A process of making a nano-structured composition. A nano-structured material is provided to initiate a mixture. A micron-sized particulate material is added to the mixture. A matrix material is added to the mixture. Finally, the mixture is utilized to fabricate a nano-structured structure.
Patent CA-2467801-C (CA)
Title: Nucleic sequences from the genome of salmonella typhi, and uses thereof particularly for the in vitro diagnosis of the presence of salmonella bacteria in foodstuffs
Inventor: POPOFF MICHAEL YVAN
IPC: C12Q1/689
Filed: 1991-07-11
Granted: 2008-09-16
Abstract: New nucleic acid sequence (I) contains all or part of the genetic information necessary for in vitro infection activity for Salmonella in Hela cultured cells. Also new are (1) any sequence which hybridises with (I) under stringent conditions; (2) sequences (II) of about 200-500 nucleotides from (I) useful as probes, and sequences (III) of 10-30 nucleotides useful as amplification primers; (3) polypeptides (IV) encoded by (I); (4) poly- or mono-clonal antibodies (Ab) recognising (IV) specifically; (5) recombinant nucleic acid (Ia) contg. (I) inserted into a heterologous sequence; and (6) vectors contg. (Ia).
Patent CA-2474011-C (CA)
Inventor: DE WAAL MALEFYT RENE
IPC: C12N5/0784
Filed: 2003-01-30
Granted: 2014-03-25
Abstract: Provided herein are methods of modulating dendritic cell activity using agonists or antagonists of mammalian cytokine, comprising more specifically contacting an antigen presenting cell with an agonist of TSLP/IL 50 (SEQ ID NO:1) or TSLP/IL-50 R (SEQ ID NOs:2,3) or an antigen binding fragment thereof.
Patent CA-2478598-C (CA)
Inventor: NASTOLL WILLY
IPC: B01J38/12
Filed: 2003-01-30
Granted: 2011-03-01
Abstract: L'invention propose un procédé et un dispositif d'élimination au moins partielle de dépôts carbonés dans un échangeur de chaleur dans lequel on effectue un traitement d'oxydation comprenant au moins une étape d'oxydation contrôlée à une température conventionnelle comprise entre 400 et environ 500~C pendant une durée d'au moins 4 heures, au moyen d'un fluide oxydant comprenant majoritairement un gaz inerte, et une quantité mineure d'oxygène, dans des conditions telles que les températures des fluides alimentant ou issus de l'échangeur restent inférieures à environ 520~C pendant toute la durée du traitement d'oxydation, et en ce que l'approche chaude de l'échangeur reste inférieure à environ 120~C pendant toute la durée du traitement d'oxydation. L'invention concerne également une installation d'hydrotraitement pour la mise en oeuvre de ce procédé et de ce dispositif.
Patent CA-2480884-C (CA)
Inventor: STOLL THIERRY
IPC: A61F2/28
Filed: 2003-01-16
Granted: 2010-08-03
Abstract: L'invention concerne un implant chirurgical (1) en forme d'implant intervertébral comprenant plusieurs cavités (2) pour recevoir des matériaux de substitution osseuse entièrement synthétiques. Ceci présente l'avantage de supprimer le risque d'infection inhérent au choix d'un matériau de substitution osseuse naturel, les propriétés physiques d'un matériau de substitution osseuse synthétique n'étant en outre pas soumises à des variations (porosité, grosseur de pores, résistance à la pression mécanique).
Patent CA-2490722-C (CA)
Title: Novel benzimidazole derivatives
Inventor: OTAKE NORIKAZU
IPC: C07D401/04
Filed: 2003-06-26
Granted: 2012-05-01
Abstract: A compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally! I substituted methine; E is nitrogen, methine or hydroxyl, substituted methine; n is 0 or 1; T, U, V and W are independently!, nitrogen or optionally substituted methine; X is -N(SOZR4)-, N (COR5) - or -CO-; Y is -C (R6) (R7) - , -O- or -N (RS) - provided that the compound (I) when E is nitrogen, n is 0, X is -CO-, and Y is -0 is excluded). is useful as an agent for the treatment of various diseases related to NPY neuropeptide Y.
Patent CA-2491139-C (CA)
Inventor: THONG STEPHEN H
IPC: A61K8/39
Filed: 2003-07-08
Granted: 2009-09-29
Abstract: Disclosed are shaving compositions that contain a polyglyceryl a fatty ester surfactant and fatty alcohol. In particular the shaving composition comprises, in percent by weight, about 65 % to about 94 % water, about 1 % to about 10 %  of a C12-22 fatty alcohol, about 1 % to about 6 % of a volatile hydrocarbon propellant, and about 1 % to about 10 % of a polyglyceryl fatty ester surfactant. Preferably the shaving composition is subtantially free of anionic surface active agents such as soap or detergent.
Patent CA-2497384-C (CA)
Title: Dna mutagenesis by random fragmentation and reassembly
Inventor: STEMMER WILLEM P C
IPC: C07K16/18
Filed: 1995-02-17
Granted: 2012-01-03
Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
Patent CA-2517463-C (CA)
Inventor: SEDERBERG THOMAS W
IPC: G06F17/00
Filed: 2004-03-26
Granted: 2012-12-11
Abstract: A system and method is provided for defining a bi-cubic spline surface in a computing environment. One operation in the method is creating a control mesh with a substantially rectangular structure (150). A further operation is inferring from the control mesh the tensor product B-spline basis functions for each control point (152). The surface can then be computed based on the basis functions and the control mesh (154).
Patent CA-2524403-C (CA)
Title: Variants actifs de la proteine de liaison il-18 et utilisations medicales de ceux-ci
Inventor: ALTAROCCA VALTER
IPC: A61K38/00
Filed: 2004-05-11
Granted: 2013-07-09
Abstract: La présente invention concerne des fragments actifs de la protéine de liaison IL-18, des compositions pharmaceutiques comprenant ces fragments actifs et, des utilisations médicales de celles-ci.
Patent CA-2527699-C (CA)
Title: Railroad switch lubricator
Inventor: KUMAR SUDHIR
IPC: B61K3/00
Filed: 2004-05-20
Granted: 2012-02-28
Abstract: This invention is an electro-hydraulic system to automatically lubricate railroad switches and enhance their performance. The lubrication covers switch plates, switch rods, switch points, the base of stock rail adjacent to switch rail and the top of both switch and stock rails. Wear and tear of the switch and lateral creep force impact are thus reduced and the switch operates smoothly. Switch related derailments, rail fractures and maintenance labor will be reduced significantly. A pressurized tank with a microprocessor controller, placed on the wayside, supplies an environmentally acceptable smooth-flowing lubricant via hoses or pipes to two nozzle holders with check valves mounted with special brackets a short distance from the switch point on both rails. Lubricant is sprayed with one or more nozzles on each rail switch to cover all or part of the switch length. One or two solenoid valves in the flow lines control the quantity of lubricant applied in each shot and the frequency of application.
Patent CA-2527895-C (CA)
Inventor: ROES JOHN B
IPC: G01S17/86
Filed: 2004-06-10
Granted: 2014-02-11
Abstract: The present invention is directed toward systems for conducting laser range and enabling optical communication between a plurality of entities and to the application of such systems in a secure covert combat identification system.  In one embodiment, the present invention uses a novel laser system that generates high pulse rates, as required for optical communications, while concurrently generating sufficiently high power levels, as required by laser range finding operations. One application of the present invention is in enabling secure covert communications between a plurality of parties. Another application of the present invention is in tracking and identifying the movement of objects.
Patent CA-2532986-C (CA)
Inventor: GAO YUAN
IPC: H01M4/587
Filed: 2004-07-29
Granted: 2013-05-28
Abstract: Electrodes, such as anodes and cathodes, can include a host material that is prelithiated or undergoes lithiation upon electrolyte introduction into a battery. Lithiation of the host material can occur by the agitation of lithium metal and a host material, the agitation of a lithium metal powder and a host material at a temperature greater than room temperature, the application of pressure to a lithium metal and host material mixture, contact of the host material with molten lithium metal, the lamination of lithium foil or lithium mesh onto an electrode containing the host material, or by lamination of lithium metal or mesh onto an electrode at elevated temperatures.
Patent CA-2532990-C (CA)
Inventor: KELLER STUART R
IPC: E21B/
Filed: 2004-05-27
Granted: 2009-10-13
Abstract: A process for drilling a well or a portion of a well capable of providing a generally constant interior wall diameter (monobore) and does not require installation of any liner or steel casing. The process comprises circulating settable material into the borehole wherein the settable material sets on at least a portion of the interior wall of the borehole to create a liner along the wall of the borehole and removing excess settable material out of the borehole.
Patent CA-2535489-C (CA)
Title: Antibodies against factor viii with modified glycosylation in the variable region
Inventor: SAINT-REMY JEAN-MARIE
IPC: A61P7/02
Filed: 2004-08-16
Granted: 2014-09-30
Abstract: The present invention discloses inhibitory antibodies against Factor VIII with modified glycosylation, either by enzymatic deglycosylation or by site directed mutagenesis. Said antibodies with modified glycosylation have equal affinity for FVIII but show different inhibiting properties. The use of one or a mixture of said antibodies allow modulation of the inhibition of factor VIII  to levels between 40 and 95%. The present invention further disclosed pharmaceutical compositions comprising inhibitory antibodies against Factor VIII with modified glycosylation, combinations of these antibodies and methods for treating haemostasis disorders using said antibodies and antibody mixtures.
Patent CA-2544274-C (CA)
Inventor: DEMERS JASON A
IPC: F04B1/00
Filed: 2004-10-29
Granted: 2013-06-18
Abstract: A system, device, and method for mixing liquids involves pumping a first liquid into a first pump chamber (334) of a pumping apparatus through a channel (310) of the pumping apparatus and pumping a second liquid from a second pump chamber (333) of the pumping apparatus into either the channel or the first pump chamber, preferably while the first liquid is being pumped into the first pump chamber, so that the two liquids are mixed within the pumping apparatus. The second liquid is preferably pumped in a pulsatile mode in which small quantities of the second liquid are pumped at intervals. The quantity and/or the interval can be dynamically adjusted to result in a predetermined concentration of the two liquids. The contents of the first pump chamber are pumped to a receptacle.