Patent MX-2011001283-A (MX)
Title: Method for producing a pattern on a continuous strip.
Inventor: JEFFERY JOHN
IPC: D21F1/00
Filed: 2009-07-29
Abstract: The invention relates to a method for producing a polymer topographic pattern on a continuous strip which has a longitudinal orientation and transverse orientation perpendicular thereto, the pattern being applied to an area of the continuous strip to be imprinted by means of an application device and the application device moving in relation to the strip in a basic movement which is parallel to the transverse orientation of the strip to produce the pattern. The invention is characterized in that during production of the pattern i) the position of the continuous strip parallel to its transverse orientation, especially relative to a stationary reference position, is measured and ii) the position of the application device is changed by a correction movement parallel to the transverse orientation of the continuous strip when the position of the continuous strip parallel to its transverse orientation is changed, the correction movement being superimposed to the basic movement. The present invention relates to agonists/activators of NR2F6 (nuclear orphan receptor receptor Ear2) for the treatment of a disease related to an augmented immune response. Furthermore, pharmaceutical compositions comprising said agonists/activators of NR2F6 and a pharmaceutical carrier are comprised. In a further aspect, the present invention provides for a method for identifying immunosuppressants comprising contacting a cell, tissue or a non-human animal comprising a reporter construct for NR2F6-activation with a candidate molecule, measuring the reporter signal and selecting a candidate molecule which alters the reporter signal. Furthermore, the present invention relates to non-human transgenic animals or cells or tissue derived therefrom useful in the provided methods for identifying immunosuppressants. In yet another aspect, the present invention relates to ligand-mediated reporter gene expression constructs, ligand displacement constructs, fluorescent cellular sensor fusion mutant constructs, and ligand-induced homo- and/or heterodimer constructs useful in the provided methods for identifying immunosuppressants. The invention relates to a method for producing a polymer topographic pattern on a continuous strip which has a longitudinal orientation and transverse orientation perpendicular thereto, the pattern being applied to an area of the continuous strip to be imprinted by means of an application device and the application device moving in relation to the strip in a basic movement which is parallel to the transverse orientation of the strip to produce the pattern. The invention is characterized in that during production of the pattern i) the position of the continuous strip parallel to its transverse orientation, especially relative to a stationary reference position, is measured and ii) the position of the application device is changed by a correction movement parallel to the transverse orientation of the continuous strip when the position of the continuous strip parallel to its transverse orientation is changed, the correction movement being superimposed to the basic movement.