baber/WOPTO huggingface dataset:
Patent EP-2298768-B1 (EP)
Inventor: KAWASAKI HISASHI
IPC: C07D471/04
Filed: 2005-06-10
Granted: 2012-11-14
Abstract: The present invention relates to a pyrimidine compound represented by the following formula [I]   
wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. The compound of the present invention has superior undesirable cell proliferation suppressing action, particularly, an antitumor action, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, it can be a more effective antitumor agent.
Patent EP-2204372-B1 (EP)
Inventor: KOERNIG WOLFGANG
IPC: C05G3/90
Filed: 2006-09-15
Granted: 2012-01-04
Abstract: Separation of acids from reaction mixtures containing at least a polar end product, involves using at least an auxiliary base comprising a non-polar amine. The auxiliary base forms a salt with the acid, the acid is taken up by a further base and the auxiliary base is released again. The salt of the further base is dissolved in water and separated from the end product or the solution of the end product in a suitable polar solvent and also from the auxiliary base. The released auxiliary base forms two immiscible liquid phases with the end product. Separation of acids from reaction mixtures containing at least a polar end product, comprises using at least an auxiliary base comprising a non-polar amine and the auxiliary base forms a salt with the acid. The acid is taken up by a further base and the auxiliary base is released again. The salt of the further base is dissolved in water or in an aqueous medium and separated from the end product or the solution of the end product in a polar solvent and also from the auxiliary base. The released auxiliary base forms two immiscible liquid phases with the end product or the solution of the end product in a polar solvent. An INDEPENDENT CLIAM is included for the production of thiophosphoric acid triamides which comprises reacting thiophosphoric acid trichloride with at least a primary or secondary amine in an inert polar solvent with the use of the auxiliary base.
Patent EP-2301466-B1 (EP)
Inventor: GOVARI ASSAF
IPC: A61B19/00
Filed: 2009-06-05
Granted: 2012-08-22
Abstract: A medical probe includes a flexible insertion tube, having a distal end for insertion into a body cavity of a patient, and a distal tip, which is disposed at the distal end of the insertion tube and is configured to be brought into contact with tissue in the body cavity. A coupling member couples the distal tip to the distal end of the insertion tube and includes a tubular piece of an elastic material having a helical cut therethrough along a portion of a length of the piece.
Patent EP-2298278-B1 (EP)
Inventor: LADNER ROBERT CHARLES
IPC: A61K9/00
Filed: 2003-06-06
Granted: 2015-11-11
Abstract: A polypeptide comprising the amino acid sequence: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (amino acids 3-60 of SEQ ID NO:2), wherein the polypeptide inhibits kallikrein.
Patent EP-2329847-B1 (EP)
Inventor: JORDAN CRAIG T
IPC: A61P7/00
Filed: 2001-03-06
Granted: 2016-11-02
Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R alpha or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells.; These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.
Patent EP-2271190-B1 (EP)
Inventor: BRANDT AARON D
IPC: H05H1/34
Filed: 2004-04-09
Granted: 2019-11-13
Abstract: A coolant tube and electrode are adapted to mate with each other to align the tube relative to the electrode during operation of the torch. Improved alignment ensures an adequate flow of coolant along an interior surface of the electrode. In one aspect, an elongated body of the coolant tube has a surface adapted to mate with the electrode. In another aspect, an elongated body of the electrode has a surface adapted to mate with the coolant tube. The surfaces of the tube and electrode may, for example, be flanges, tapered surfaces, contours, or steps.
Patent EP-2467053-B1 (EP)
Inventor: SCHUTTE SANDER
IPC: A61B3/08
Filed: 2010-08-19
Granted: 2013-04-03
Abstract: Apparatus and method for automatically determining a strabismus angle of the eyes of an individual by performing a reflection test on said eyes, comprising the steps of : -directing at least a first beam of light onto said eyes of the individual; -having the individual focus its eyes; -using at least one imaging device for: measuring the light beam reflected from the eyes for establishing which eye is fixating, and performing a reflex test on both eyes to estimate the strabismus angle, wherein -the reflex test is carried out by applying at least two light sources at known differing positions and measuring the corneal reflections of said light sources in both eyes by monitoring said corneal reflections by an imaging device or devices; -the said corneal reflections are used to derive corneal center coordinates for both eyes individually; -for both eyes individually pupil center coordinates are estimated; -the corneal center coordinates and the pupil center coordinates of both eyes are used to estimate the strabismus angle. For the eye that is fixating an angle kappa is calculated representing an angle between the eyes' optical axis through the corneal center and the pupil center, and the visual axis through the corneal center and the eye's fovea, and the angle kappa is then used for determining the strabismus angle.
Patent EP-2382856-B1 (EP)
Inventor: OTTERSBACH HANS
IPC: B02C4/08
Filed: 2006-11-03
Granted: 2014-01-01
Abstract: Comminuting arrangement has two comminuting rollers, which are driven in opposite directions and have a curved lateral surface in axial direction and are arranged in interlinked manner. Shaft flanks of the first comminuting roller (10) have concave sections (13) and shaft flanks of second comminuting roller (20) have convex sections (23). The shaft flanks of first and second comminuting roller have an additional straight section (12,14). An independent claim is included for the blade element for comminuting roller.
Patent EP-2371568-B1 (EP)
Inventor: TAKEDA KENGO
IPC: B41J29/17
Filed: 2011-03-30
Granted: 2013-12-18
Abstract: An image recording apparatus includes: a recording portion; a conveying member having a surface opposed to the recording portion and which conveys the recording medium in a conveying direction; a wiper having an end portion which is contactable with the surface of the conveying member and which removes a foreign matter on the surface of the conveying member; and a wiping operation executing portion which executes a wiping operation in which at least one of the wiper and the conveying member is driven such that, after the end portion of the wiper distant from the surface of the conveying member comes into contact with a clean area of the surface of the conveying member, the end portion of the wiper reaches outside of the clean area.
Patent EP-2583819-B1 (EP)
Inventor: BUCHET YANN
IPC: B32B5/26
Filed: 2011-10-17
Granted: 2013-12-11
Abstract: Laminating component (1), preferably an interior trim component, comprising at least one seam (2) with a laminating material (3), comprises (a) applying the laminating material on the surface of the component, (b) aligning the seam of laminating material depending on the contour of the component, and (c) fixing the laminating material on the component, where at least one function thread (4) is threaded over the entire course of the at least one seam before step (b) into the seam of the laminating material. Laminating a component (1), preferably an interior trim component, comprising at least one seam (2) with a laminating material (3), comprises (a) applying the laminating material on the surface of the component, (b) aligning the seam of laminating material depending on the contour of the component, and (c) fixing the laminating material on the component, where at least one function thread (4) is threaded over the entire course of the at least one seam before step (b) into the seam of the laminating material, where the loops for receiving a positioning aid (6) is formed with the function thread above the surface of laminating substance, and the alignment of the seam of the laminating material in step (b) is carried out by the positioning aid introduced in the loops of the thread function.
Patent EP-2421163-B1 (EP)
Inventor: TAYLOR MATTHEW PAUL ATHOL
IPC: H04L1/00
Filed: 2008-10-17
Granted: 2013-03-13
Abstract: A data processing apparatus is arranged to map input data symbols to be communicated onto a predetermined number of sub-carrier signals of Orthogonal Frequency Division Multiplexed OFDM symbols. The predetermined number of sub-carrier signals is determined in accordance with one of a plurality of operating modes and the input data symbols are divided into first sets of input data symbols and second sets of input data symbols. The data processing apparatus comprises an interleaver operable to perform an odd interleaving process which interleaves the first sets of input data symbols on to the sub-carrier signals of first OFDM symbols and an even interleaving process which interleaves the second sets of input data symbols on to the sub-carrier signals of second OFDM symbols, such that while the input data symbols from the first set are being read from locations in the interleaver memory, input data symbols from the second set can be written to the locations just read from and when input data symbols from the second set are being read from the locations in the interleaver memory, the input data symbols from a following first set can be written to the locations just read from. Furthermore, when the number data symbols which can be carried by the sub-carriers of an OFDM symbol in one of the plurality of operating modes is half or less than half of the number of data symbols, which can be carried in an operating mode which provides the most number of data bearing sub-carrier signals per OFDM symbol, the data processing apparatus is operable to interleave the input data symbols from both first and second sets in accordance with the odd interleaving process on to the first and second OFDM symbols, and to change the permutation code which is used to form the addresses from one OFDM symbol to another.
Patent EP-2545976-B1 (EP)
Inventor: DALLAS ANDREW JAMES
IPC: C12N5/00
Filed: 2007-02-13
Granted: 2016-08-03
Abstract: The assemblies of the invention can comprise a fine fiber layer having dispersed within the fine fiber layer an active particulate material. Fluid that flows through the assemblies of the invention can have any material dispersed or dissolved in the fluid react with, be absorbed by, or adsorbed onto, the active particulate within the nano fiber layer. The structures of the invention can act simply as reactive, absorptive, or adsorptive layers with no filtration properties, or the structures of the invention can be assembled into filters that can filter particulate from a mobile fluid while simultaneously reacting, absorbing, or adsorbing materials from the mobile fluid.
Patent EP-0007722-B1 (EP)
IPC: B29C48/90
Filed: 1979-07-05
Granted: 1985-02-13
Abstract: A foam extrusion apparatus and method employs an extruder (37,38) on an upper level extruding foamable extrudate into the upper end of a large elongated barometric leg (32) which extends at a relatively shallow angle into a pool of water (29) at a lower level. A conveyor (43) in the barometric leg-extends through a large radius in the pool (29) to guide the extrudate from the pool (29) for further processing. The leg (32) is in the form of an elongated pipeline fabricated from sections and supported on an inclined ramp (22). Some of the sections are securely anchored to the ramp 122) to resist axial forces when the leg is evacuated. The sections may be reinforced concrete or fabricated reinforced steel of a variety of sectional shapes. Each section is sealed end-to-end so that a vacuum within the leg (32) will draw water from the pool (29) into the leg (32) leaving a vacuum chamber at the upper end of the leg in which the extrudate expands. The leg may be provided with a number of windows for visual access and the two levels may be the floors (20,21) of two horizontally and vertically separated plants. The lower end of the leg may be provided with a baffle where it enters the pool (29).
Patent EP-0010988-B1 (EP)
IPC: G01N33/24
Filed: 1979-11-05
Granted: 1984-05-30
Abstract: A quasi-static electrical friction sleeve cone penetrometer probe which includes a main body (10), portion of the body (10) being a cone load cell (11) connectible to a cone (16) for measurement of cone resistance. A friction sleeve load cell (14) is connectible to the main body (10), and a friction sleeve load cell (14) is connectible to the main body (10), and a friction sleeve (18) is connectible to the friction sleeve load cell (14) for separate measurement of side friction. Each load cell (11), (14) has strain gauges attached around an outer surface, and balancing circuitry located within the cell. The friction sleeve (18) is supported against lateral forces by three annular sleeves (30, 68, 48) located on the main body (10), friction sleeve load cell (14) and the cone (16).
Patent EP-0016180-B1 (EP)
IPC: F16H55/08
Filed: 1980-03-11
Granted: 1984-02-15
Abstract: Gear tooth (11, 13) profiles afford a higher torque capacity than that of previously disclosed finepitch gearing. To offset the weakness in bending of fine teeth (11, 13), the transmitted force is divided among two to five times as many teeth as in conventional gearing, by using very low pressure angles, and the tooth (11, 13) interference that would occur between meshed involute teeth (11, 13) of equally small pressure angle is avoided by using profiles of shorter relative radius of curvature. The tooth (11, 13) flexibility need to offset tooth (11, 13) separation at the ends of the line of action and to insure an equitable division of the load among the maximum number of teeth (11, 13) is obtained by deepening the dedenda. The resulting tooth (11, 13) form increases torque capacity by maximizing the transverse contact ratio and minimizes operating noise by increasing the axial contact ratio.
Patent EP-0014984-B1 (EP)
IPC: C07H13/08
Filed: 1980-02-18
Granted: 1982-12-01
Abstract: Novel glucosamine-peptide derivatives of the formula:  <IMAGE> wherein m is 0 or 1; n is 0 or an integer of 1 to 9; R is lower alkyl which may be substituted with hydroxyl, or aryl; R1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom; provided that when R1 is hydrogen m is 1; R2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the  alpha -nitrogen atom when n is 0, or hydrogen when n is an integer of 1 to 9; R3 is hydrogen or lower alkyl; R4 and R5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl; R6 is hydrogen or lower alkyl; R7 is alkyl which may be substituted with lower alkoxyl or aralkyl; R8 and R9 are each hydrogen, lower alkyl or aralkyl; and (D) and (L) each indicate configurations if their respective carbon atoms are asymmetric; or an acid addition salt thereof, have immunostimulatory activity.
Patent EP-0026419-B1 (EP)
IPC: A01M1/02
Filed: 1980-09-20
Granted: 1985-01-23
Abstract: 1. Triangular roof shaped insect trap having drawers for carrying glue and pheromone, wherein a vertical supporting wall (3) for supporting the top of the roof is arranged and the upright portions (5) of the drawers border on said wall (3).
Patent EP-0027702-B1 (EP)
IPC: B65G49/06
Filed: 1980-10-08
Granted: 1984-05-09
Abstract: A conveyor drive system including an improved control circuit for a glass manufacturing apparatus transports a glass sheet (12) through a glass processing station (10). The conveyor drive system includes first (24) and second (24 min ) conveyor drives disposed on opposed lateral sides of the station (10). Each of the conveyor drives (24,24 min ) includes first (28,28 min ) and second (30,30 min ) pulleys and a continuous drive loop (26, 26 min ) trained thereover. The glass plate (12) is supported on a plurality of elongated rollers (36) that extend between the conveyor drives (24,24 min ) and have their opposed ends supported on and in frictional engagement with the continuous drive loops (26,26 min ). A drive motor (40) applies drive torque to the first pulleys (28, 28 min ), and a pair of counter-poised drive motors (42,42 min ) apply a counter-torque to the second pulleys (30,30 min ). The control circuit for controlling the energization of the first drive motor (40) and the pair of counter-poised drive motors (42,42 min ) includes a feedback circuit which provides degenerative speed feedback for stabilizing the motion of the conveyor drive system.
Patent EP-0029811-B1 (EP)
IPC: D01F4/00
Filed: 1980-11-21
Granted: 1984-05-30
Abstract: Catgut suturing filament protected by a flexible polymer sheath that is slowly hydrolytically degradable and impervious to body fluid degratative enzymes. The sheath is prepared by coating the catgut filament with an isocyanate capped polyhydroxylated polyester followed by curing.
Patent EP-0044958-B1 (EP)
IPC: C08L69/00
Filed: 1981-06-29
Granted: 1984-10-31
Abstract: Plasmapheresis membranes of hydrophilic polycarbonates are disclosed, comprising polycondensates of bisphenol A and a polyalkylene oxide. These membranes which have a regular pore structure with smoothly rounded pores with openings without sharp edges, have an average pore diameter of about 0.01 to 0.8 mu , a porosity preferably above 65%, and a thickness of between about 50 and 300 mu . Processes for preparing these membranes are also disclosed, including casting a 3 to 20 weight percent polycarbonate polymer solution onto a smooth surface, contacting the layer with a gelling medium prior to precipitation of the membrane, and subsequent precipitation of the gelled layer to form the membrane.
Patent EP-0050875-B1 (EP)
IPC: C04B35/58
Filed: 1981-10-28
Granted: 1983-07-20
Abstract: The invention relates to a process for the manufacture of substantially pore-free shaped articles of polycrystalline material such as aluminium oxide, titanium boride, silicon nitride or silicon carbide, in which pulverulent materials or preformed articles having pores open towards the surface, in a vacuum-tight sealed glass casing that has a viscosity of less than 106 Pas at the pressing temperature employed, are isostatically hot-pressed in a high-pressure autoclave using an inert gas as pressure-transfer medium. By being embedded in a flowable pile or by having a layer applied to them in the form of a suspension, the glass-encased powders or articles are brought into contact with a heat-resistant pulverulent material that, upon softening of the glass casing, penetrates into the surface of the glass of reacts with it, with the result that the glass casing is reinforced from the outside at the pressing temperature. As pulverulent materials, there may be used titanium boride, graphite, SiC or boron nitride, which do not react with the glass casing, or glass powder or silica, which react with the glass casing to form a glass melt of at least the same viscosity as, or of a higher viscosity than, the glass casing.
Patent EP-0043679-B1 (EP)
Title: Flexible sheet material
IPC: F16J15/00
Filed: 1981-06-26
Granted: 1984-03-07
Abstract: Flexible sheet material suitable for use in the manufacture of gaskets has a basis (85-95% by weight) of fine particles of a non-fibrous charged-layer-silicate mineral such as chlorite and includes a minor proportion (at least 2% but not more than 15% by weight of the material) of organic web-forming fibers, preferably cellulose fibers. The fine particles of the silicate mineral and the web-forming fibers are bound together with a synthetic rubber.
Patent EP-0042399-B1 (EP)
Title: Pompe d'injection miniature
IPC: F04C5/00
Filed: 1980-11-20
Granted: 1984-09-12
Abstract: Un appareil a pompe de pression (10) pour des fluides se trouvant dans des tubes flexibles (12), lequel appareil comprend un organe de pression (30) ayant une peripherie sensiblement circulaire concue pour un mouvement orbital autour d'un axe de rotation (32). Un manchon (34) est positionne autour de l'organe de pression (30) et definit des moyens de canaux (36, 38) de reception et de retenue du tube flexible (12) dans une position predeterminee entre l'organe de pression (30) et le manchon (34), et entourant l'organe de pression (30). Le manchon (34) peut etre divise en une paire de machoires sensiblement semi-circulaires (34a, 34d) assujetties l'une a l'autre a une extremite de maniere articulee, pour permettre l'ouverture et la fermeture des machoires autour de l'organe de pression (30) pour faciliter l'installation du tube (12).
Patent EP-0070024-B1 (EP)
IPC: C07D417/12
Filed: 1982-07-12
Granted: 1985-06-26
Abstract: The crystalline anhydrous form of [3S-[3 alpha (Z),4 beta ]]-3-[[2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]ami no]-4-methyl-2-oxo-1-azetidinesu lfonic acid is prepared.
Patent EP-0073546-B1 (EP)
IPC: F16H45/02
Filed: 1982-08-26
Granted: 1987-07-01
Abstract: A transmission, in particular for a motor vehicle, includes an infinitely variable V-belt transmission with a primary pulley having a primary shaft and a secondary pulley, each having two conical sheaves, a primary and a secondary hydraulic operating cylinder, respectively, for the axial displacement of at least one of the conical sheaves of each pulley, a hydraulic control valve for the control of the transmission ratio, the valve having a housing and an internal valve spool that can be displaced from an end position in which the valve spool rests against a stop and the valve housing having ports openable for the discharge of fluid from the primary operating cylinder and/or the supply of fluid to the secondary operating cylinder, to a center position where ports are substantially closed, so that virtually no supply of fluid to and discharge of fluid from at least one of the operating cylinders can take place, a hydrodynamic transmission unit having a rotary output member connected to said primary shaft and a rotary input member adapted to be driven by a power source, a lock-up device for locking the input and output members together and a lock-up control device responsive to the position of the valve spool between the end position and the center position.
Patent EP-0076136-B1 (EP)
IPC: A61K31/785
Filed: 1982-09-27
Granted: 1989-09-20
Abstract: This invention relates to the quaternary ammonium salt, α-4-[1-tris (2-hydroxyethyl) ammonium chloride-2-butenyl] poly [1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride, providing aqueous disinfecting solutions for contact lenses as well as a preservative for ocular solutions including contact lens treating solutions.