Patent GB-770021-A (GB)
Title: Feedstuff formulations
IPC: A23K20/195
Filed: 1953-05-15
Abstract: Animal feed supplements contain crystals of water-insoluble amine salts of penicillin, other than procaine penicillin, of length exceeding 100 microns.  Crystals of this size are obtained on crystallizing at a temperature of 10-30 DEG  C. maintained for one hour or longer, previously prepared small particles of the amine salt being dissolved in an organic solvent, water being added, and crystallizing in these conditions being allowed to take place, or crystals being allowed to form in these conditions from a reaction mixture of the amine and penicillin, e.g. from a mixture of an aqueous solution of the hydrochloride, hydrobromide, sulphate, nitrate, phosphate, acetate or formate of the amine and an aqueous solution of the penicillin in the form of its alkali metal, alkaline earth metal, ammonium, ethylamine, triethylamine or N-ethylpiperidine salt or from a mixture of a water-insoluble form of the amine in ether, propanol, amyl acetate, isopropyl ether, methyl isobutyl ketone, dioxane, methanol or formamide and a solution of penicillin in an organic solvent.  The water-insoluble salts are exemplified by dibenzylamine benzylpenicillin, N,N1-dibenzylethylenediamine dipenicillin, N,N1-dibenzylethylenediamine dipenicillin, quinine benzyl penicillin, p-aminobiphenyl penicillin, cyclohexylamine penicillin, N-hexyldimethylamine penicillin, o-benzylphenol dimethylaminoethyl ether penicillin, dicyandiamidine penicillin, dehydroabietylamine penicillin and 2-amino-4-methyl - 6 - methoxypyrimidine benzylpenicillin. Examples of the penicillins of the amine salts are penicillin F, penicillin dihydro F, penicillin G, penicillin K and penicillin X. Specification 770,022, [Group I], is referred to.ALSO:An animal feed supplement comprises a water-insoluble amine salt of penicillin, other than procaine penicillin, in the form of crystals of length exceeding 100 microns dispersed throughout a solid carrier, e.g. Attapulgus clay, ground oyster shell, pulverized limestone, which is nutritionally inert or acceptable to the animals.  The supplement may contain 4 g. of the salt per kg. of carrier.  The supplement may include substances containing vitamin B12 and the animal protein factor.  1 to 300 mg. of penicillin may be present in 1 kg. of the feed containing the supplement.  According to examples, the feed supplement is blended with a riboflavin supplement, D-activated animal sterol, soybean oil meal, corn gluten meal, fish meal, dried whey, dehydrated alfalfa meal, maize meal, wheat middlings, pulverized oats, bone meal, calcium carbonate, salt and manganese sulphate in preparing a chicken feed, the mixture so prepared is moistened by steam, compressed between rollers and cut to 5/16 in. long and 3/16 in. diameter pellets, and the pellets are dried, cooled, and hardened in an air stream.  The water-insoluble amine salts specified are: dibenyzalmine benzylpenicillin, N, N1-dibenzylethylenediamine dipenicillin, quinnine benzylpenicillin, p-aminobiphenyl penicillin, cyclohexylamine penicillin, N-hexyldimethylamine penicillin, o-benzylphenol dimethylaminoethyl ether penicillin, dicyandiamidine penicillin, dehydroabietylamine penicillin and 2-amino-4-methyl-6 methoxypyrimidine benzylpenicillin.  Examples of the penicillins of the amine salts are penicillin F, penicillin dihydro F, penicillin G, penicillin K and penicillin X.  Specification 770,022 is referred to.