baber/WOPTO huggingface dataset:
Patent FI-930491-A0 (FI)
Inventor: UEDA YASUTSUGU
IPC: C07D305/14
Filed: 1993-02-04
Abstract: A taxol derivative of formula I <CHEM>  or a pharmaceutically acceptable salt thereof, in which   R<j> is   -COR<z> in which R<z> is t-butyloxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, or phenyl, optionally substituted with one to three same or different C1-6 alkyl, C1-6 alkoxy, halogen or -CF3 groups; R<y> is   C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, or a radical of the formula -W-R<x> in which W is a bond, C2-6 alkenediyl, or -(CH2)t-, in which t is one to six; and R<x> is naphthyl, furyl, thienyl or phenyl, and furthermore R<x> can be optionally substituted with one to three same or different C1-6 alkyl, C1-6 alkoxy, halogen or -CF3 groups; R<w> is   hydrogen, hydroxy, acetyloxy, -OC(=O)OY or -OZ; R<1> is   hydrogen, hydroxy, -OC(=O)OY or -OZ; R<2> is hydroxy, -OC(=O)OY, -OC(=O)R or -OZ, with the proviso at least one of R<1>, R<2> or R<w> is -OC(=O)OY or -OZ; R is   C1-6 alkyl; Z is   of the formula <CHEM>  or   <CHEM>  wherein   R<3> and R<4>   are independently hydrogen or C1-6 alkyl, or R<3> and R<4> taken together with the carbon atom to which they are attached form C3-6 cycloalkylidene; R<5> is   -OC(=O)R, -OP=O(OH)2 or -CH2OP=O(OH)2; R<6>, R<7>, R<8> and R<9>   are independently halogen, C1-6 alkyl, C1-6 alkoxy or hydrogen; or one of R<6>, R<7>, R<8> and R<9> is -OC(=O)R, -OP=O(OH)2 or hydroxy, and the others are independently halogen, C1-6 alkyl, C1-6 alkoxy or hydrogen; but when R<5> is -OC(=O)R, one of R<6>, R<7>, R<8> or R<9> must be -OP=O(OH)2; Q is   -(CH2)q-, optionally substituted with one to six same or different C1-6 alkyl or C3-6 cycloalkyl, or a carbon atom of said -(CH2)q- group can also be a part of C3-6 cycloalkylidene; q is   2 to 6; n is 0, and m is 1 or 0 when R<5> is -CH2OP=O(OH)2; n is 1 or 0, and m is 1 when R<5> is -OC(=O)R or -OP=O(OH)2; Y is   C1-6 alkyl (optionally substituted with -OP=O(OH)2 or one to six same or different halogen atoms), C3-6 cycloalkyl, C2-6 alkenyl, or a radical of the formula   <CHEM>  in which D is a bond or -(CH2)t-, optionally substituted with one to six same or different C1-6 alkyl; and R<a>, R<b> and R<c> are independently hydrogen, amino, C1-6alkylamino, di-C1-6alkylamino, halogen, C1-6 alkyl, or C1-6 alkoxy; and with the further proviso that R<2> cannot be -OP=O(OH)2; and Y cannot be -CH2CCl3.
Patent FI-941324-A0 (FI)
Inventor: HOLTON ROBERT A
IPC: C07F7/00
Filed: 1994-03-22
Abstract: 10-Desacetoxytaxol and its derivs. of formula (I) are new, where R2 = H or opt. protected OH; R3, R4 = H, opt. protected OH, Me, -SH, -NH2 or -NR8R9; R5 = R10 or -OR10; R6, R7 = H, alkyl or aryl; R8, R9 = H, alkyl, alkenyl, alkynyl or aryl; R10 = alkoxy, alkyl, alkenyl, alkynyl or aryl; provided that when R2 = H then R3 and R4 are not opt. protected OH. 10-Desacetoxytaxol and 10- desoxytaxotere, are specifically claimed.
Patent FI-951207-A0 (FI)
Inventor: SCHWEIZER PAUL
IPC: B29C53/30
Filed: 1995-03-15
Abstract: PCT No. PCT/CH94/00148 Sec. 371 Date Feb. 16, 1995 Sec. 102(e) Date Feb. 16, 1995 PCT Filed Jul. 13, 1994 PCT Pub. No. WO95/02503 PCT Pub. Date Jan. 26, 1995For producing a protective layer made of a sheet, a device exhibits an oblong guide element (1) with an upper edge (2), by way of which a sheet (7) can be folded in its longitudinal direction. Clamping elements (15, 16), designed as sliders, are arranged on the side of the guide element (1); and the sheet (7), folded in its longitudinal direction, can be grasped on both sides of the guide element (1) with said clamping elements. To form folds in the sheet (7), the clamping elements (15, 16) can be slid in the longitudinal direction of the guide element (1).
Patent FI-952482-A0 (FI)
Inventor: BOUCHARD HERVE
IPC: A61K31/335
Filed: 1995-05-22
Abstract: PCT No. PCT/FR93/01145 Sec. 371 Date May 23, 1995 Sec. 102(e) Date May 23, 1995 PCT Filed Nov. 22, 1993 PCT Pub. No. WO94/12484 PCT Pub. Date Jun. 9, 1994This invention relates to a method for the preparation of taxane derivatives having the formula (I) and pharmaceutical compositions which contain the derivatives thus obtained. In formula (I), R is hydrogen or acetyl, R1 is benzoyl or R2-O-CO wherein R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and Het is a 5-membered optionally substituted aromatic heterocycle (thiophene, tiazole, furan, pyrrole, imidazole, oxazole, isoxazole, pyrazole). The products of formula (I) have remarkable antitumor and antileukemia properties.    <IMAGE>  (I)
Patent FI-962686-A0 (FI)
Inventor: KEINAENEN KARI
IPC: G01N33/536
Filed: 1996-06-28
Abstract: This invention relates to a fluorescence-based immunoassay method for the detection of an analyte, or for the measurement of its concentration in a biological sample. The method is based on the ability of a multivalent analyte to induce aggregation of receptor molecules labeled with a fluorophore, which molecules are anchored to and are freely mobile on a lipid membrane, and thereby cause changes in the fluorescence.
Patent FI-991134-A0 (FI)
Inventor: HILTUNEN MATTI
IPC: G06F1/00
Filed: 1999-05-18
Abstract: In a method and system for authenticating locally-stored program code, a first checksum is computed using the locally-stored program code, the computed checksum is compared with a second checksum known to be valid and, if the two checksums are determined to match, the locally-stored program code is deemed valid and authentic. For increased certification reliability and dependability, before computation of the first checksum a predetermined challenge is added to the stored program code, so that the first checksum is computed from the combination of the stored program code and the challenge. This enhancement enables secure use of stored program code in applications that demand high security. Users of such software may therefore rely on the authenticity of the data processed by the software and of the data and results reported on the display of a mobile phone or keyboard throughout the entire process or transaction.
Patent AP-9801317-A0 (AP)
Title: Building block
Inventor: HORWITZ LIONEL HAROLD
IPC: E04B2/16
Filed: 1997-01-09
Abstract: A self-locating building block (10)has a longitudinal tongue (12); a longitudinal groove (16)at the bottom, the longitudinal groove (16)being such that the longitudinal tongue (12)of a similar block (10)is receivable in the longitudinal groove (16)when the blocks (10)are laid in superimposed courses; and cavities (18)extending through the block (10)from top to bottom. The cavities (18)are at least as wide as the longitudinal tongue (12), so as to give the longitudinal tongue (12)a castellated form (12.1, 12.2, 12.3)in side elevation.
Patent AP-9801350-A0 (AP)
Title: Parasitical formulations.
Inventor: HUATAN HIEP
IPC: A61K9/00
Filed: 1998-09-17
Abstract: The invention provides a solid implant comprising at least one parasiticidal compound having low aqueous solubility; and tabletting excipients including a bulking agent. Implants according to the invention are convenient to administer and provide prolonged protection against parasites.
Patent IL-64314-A0 (IL)
Title: 2-oxoazetidine derivatives,their production and use
IPC: C07D205/00
Filed: 1981-11-19
Abstract: 1-Sulfo-2-oxoazetidine derivatives of the general formula (I) 
<CHEM>
 wherein R1 is amino group which may optionally be acyiated or protected, X is hydrogen or methoxy, and R4 is azido, a halogen, amino group which may optionally be acylated or a group of the formula -OR5, 
<CHEM>
 or -S-S-R5 in which R5 is an organic residue and n is 0, 1 or 2, or a pharmaceutically acceptable salt thereof, or an ester thereof as well as methods of production in accordance with the following schemes: 
<CHEM>
 wherein R2 is an acylated or protected amino group, R3 is an acylated amino group, and R1 and R4 are as above defined. The compounds [I] have antimicrobial and  beta -lactamase inhibitory activity.
Patent IL-74634-A0 (IL)
Title: 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IPC: C07D/
Filed: 1985-03-18
Abstract: 1,4-Dihydropyridine derivs. of formula (I) and their acid addn. salts are new. R = OH, 1-4C opt. branched alkoxy which may be substd., such as methoxy or methoxymethoxy, or 2 gps. R on adjacent atoms form an alkylenedioxy gp., such as methylenedioxy or ethylenedioxy n = 1,2 or 3 R1 and R2 = 1-4C opt. branched alkyl which may be substd., such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, methoxyethyl or 2-pyridylmethyl. -
Patent IL-84866-A0 (IL)
Title: Method for detecting tumors
IPC: G01T1/161
Filed: 1987-12-17
Abstract: Methods are provided for short-range intraoperative and endoscopic detection and therapy of tumors using radiolabeled antibodies and, in some cases, techniques for reducing or correcting for non-specific background radiation to improve resolution. Therapy using external radiation and/or laser or mechanical endoscopically introduced tumor removal means can be combined with the detection methods to increase precision of the tumor removal operations.
Patent IL-91875-A0 (IL)
Title: Apparatus and method for monitoring a predisposition to kidney stone formation
IPC: G01N33/50
Filed: 1989-10-04
Abstract: Apparatus for indicating a predisposition to kidney stone disease in humans, and also dehydration, and for monitoring the efficacy of hydration therapy, comprises a conductivity probe including a tip (11) which can be inserted into urine so that a drop thereof adheres to the tip, and display means for indicating the result as a derived function of conductivity (electrolyte concentration) in terms of urine specific gravity or osmolality. Preferably the probe electrodes (12, 13) are small and are spaced closely together so that the streamlines between the electrode tips are such that maximum current flows substantially within the adherent drop of urine.
Patent IL-94176-A0 (IL)
Title: Level sensor device for household appliances
IPC: A47L15/42
Filed: 1990-04-23
Abstract: This invention relates to a level sensor device for household appliances or the like. The device comprises a compartment (25) which at its lower part via a single combined in- and outlet (42) is connected to a treatment chamber into which liquid is supplied. The upper part of the compartment (25) is divided into two sections (26, 27) one section (26) communicating with a pressure sensing means and the other section (27) communicating with atmosphere. The combined in- and outlet (42) is placed between the two sections. By this arrangement a rapid and complete emptying of the sensor is safeguarded when the treatment chamber is emptied.
Patent IL-94978-A0 (IL)
Title: 3,5-dihydroimidazo(2,1-b)-quinazolin-2(1h)-one derivatives,their preparation and pharmaceutical compositions containing them
IPC: C07D487/10
Filed: 1990-07-05
Abstract: Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula <CHEM> the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl;  R<1> is hydrogen of C1-6alkyl;  R<2> is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or  R<1> and R<2> taken together may also form a C1-5alkanediyl radical;  X is a radical of formula  =O      (a),  =N-O-R<3>      (b),or  =CH-R<4>      (c); R<3> is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR<5>R<6> or COOCH2CONR<7>R<8>; R<4> is COOH, COOC1-4alkyl, CONR<5>R<6>, COOCH2CONR<7>R<8> or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR<5>R<6> or COOCH2CONR<7>R<8>. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.
Patent IL-98577-A0 (IL)
Title: Arrangement for enclosing a branch-off between a pair of cables
IPC: H02G15/18
Filed: 1991-06-21
Abstract: PCT No. PCT/GB91/00994 Sec. 371 Date Dec. 16, 1992 Sec. 102(e) Date Dec. 16, 1992 PCT Filed Jun. 20, 1991 PCT Pub. No. WO92/00623 PCT Pub. Date Jan. 9, 1992.An arrangement for enclosing a branch-off between a pair of cables (2,3,4) comprises a dimensionally recoverable sleeve (5) which can surround the branch-off, and one or more clips (6) which can be positioned about opposed walls of the sleeve to divide the sleeve into channels for the cables. The or each clip (6) is of unitary form and has a pair of legs (8) that are splayed outwardly to facilitate positioning of the clip over the sleeve walls. The or each clip is deformable so that the legs can be forced towards each other after the clip has been positioned on the sleeve walls but is sufficiently rigid, at least in its deformed state, it will resist opening out of the legs under the recovery forces of the sleeve. The invention provides a relatively simple and easy to install enclosure for branch-offs in harnesses for example that are intended to be used in automotive vehicles.
Patent IL-99091-A0 (IL)
Title: Facetted light pipe
IPC: G02B6/00
Filed: 1991-08-05
Abstract: A light pipe (100) used for backlighting liquid crystal displays (D) has a planar front surface (110) and a stepped or faceted back surface (112). Light is injected from the ends (105) of the light pipe from cold or hot cathode, apertured, fluorescent lamps (108). The cold cathode lamps are preferably insulated to raise their operating temperature. The back surface has a series of planar portions (114) parallel to the front surface connected by facets (116), which are angled so that the injected light reflects off the facets and through the front surface. A reflector (126) having a planar, highly reflective, highly scattering surface or a sawtoothed or grooved upper surface is located adjacent to and parallel with the light pipe back surface to reflect light escaping from the back surface back through the light pipe to exit the front surface. The axes any grooves are preferably slightly skewed from the facet axis to reduce moire pattern development. A low scattering or loss diffuser (111) is located adjacent to and parallel with the light pipe front surface to reduce moire pattern development. The liquid crystal display (D) is located over the low scattering diffuser. A separate injector (104) may be located between the lamp and the light pipe to better couple the light into the light pipe. <IMAGE>
Patent AU-PQ182899-A0 (AU)
Title: Retractor
IPC: A61B17/02
Filed: 1999-07-27
Abstract: A retractor for use in surgery, such as chest surgery, comprises two arms ( 4,6 ) each adapted to carry a blade ( 14,16 ) engageable with one side of an incision, the two arms ( 4,6 ) being connected by a pivot ( 8 ) at one end portion such that the arms ( 4,6 ) can be pivoted between a closed position and an adjustable open position in which the arms define a substantially V-shaped configuration in which the blades ( 14,16 ) maintain the sides of the incision in inclined relation. The arms are moved to the open position by means of a curved rack ( 20 ) carried by one of the arms ( 6 ) and a pinion ( 28 ) carried by the other arm ( 4 ), the pinion ( 28 ) being releasably lockable to retain the arms in the open position by a ratchet and pawl mechanism.
Patent FI-20021248-A0 (FI)
Inventor: JONKKA ARVO
IPC: B27L11/00
Filed: 2002-06-26
Abstract: The invention concerns a method for clamping a knife of a disc chipper, wherein the knife is pressed from the knife disc via knife a clamp against a wear plate in a diagonal position (alpha) with respect to the plane of the knife disc with a compressive force (N) substantially parallel with the axis of the knife disc. According to the invention, the compensating force of the force directed to the knife clamp, caused by the diagonal position (alpha) of the knife and transversal to the compressive force (N) is exerted to the wear plate.
Patent FI-20065731-A0 (FI)
Inventor: WAHLSTROEM RAUNO
IPC: H04W4/029
Filed: 2006-11-16
Abstract: This invention relates to positioning a mobile terminal device at the request of a user and indicating location on a map base that is downloaded to a mobile terminal device. Particularly, the invention relates to downloading a map where the location of the mobile terminal device that requested the service is marked. Furthermore, the invention relates to downloading a map indicating the location of a mobile terminal device to another mobile terminal device. The invention also relates to downloading a map indicating the location of a second mobile terminal device designated by the mobile terminal device that requested the service to a third mobile terminal device.
Patent FI-20075334-A0 (FI)
Inventor: MOISIO MARKO
IPC: E04B/
Filed: 2007-05-10
Abstract: A method and an apparatus for erecting at least the frame (2, 3, 4, 5) of a building, in which a foundation (1) is at first formed for the building, subsequent to which a frame (2, 3, 4, 5) is erected on the foundation so that at the frame structure of at least one floor is formed first. Subsequent to erecting the first floor the frame of the building is lifted at least one floor upwards and the frame structure (2, 3, 4, 5) of at least one floor is formed below the lifted floor. Subsequent to this, the foundation is formed by piles (1) driven into the ground and having a hollow inside, at least one pillar (2, 3, 4) is placed inside the pile (1) and the pillar is lifted from inside the pile (1) for lifting the frame (2, 3, 4, 5) of the building.
Patent FI-20115697-A0 (FI)
Inventor: SANTONEN TEEMU
IPC: B42D/
Filed: 2011-07-01
Abstract: The invention provided is a count-down calendar (7, 7*) having cells hiding information and with closures (1a - 30a, 2b - 30b) to be opened. The calendar (7, 7*) has a layered structure in that the cells have a double or multi-functionality in presenting information in different parts behind two or more closures (1a - 30a, 2b - 30b) on or behind eachother.
Patent IL-109309-A0 (IL)
Title: 1H-indole-3-acetic acid hydrazide sPla2 inhibitors
IPC: A61P27/16
Filed: 1994-04-12
Abstract: A class of 1H-indole-3-acetic acid hydrazides, represented by the formula (I) <CHEM> is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.
Patent IL-117985-A0 (IL)
Title: Wrought iron grating assembly
IPC: E06B9/01
Filed: 1996-04-21
Abstract: The grating comprises longitudinal (1) and transverse (2) bars. The latter are indented to accommodate the longitudinal ones where they cross, the longitudinal ones fitting partly inside the indentations. At these positions, the bars are permanently secured together by set-screws (12, 13), which pass through bores (11) in the longitudinal members and engage in blind tapped holes (21) in the transverse bars. The set-screws can be Allen-headed, steel balls (13) being hammered into the heads. The longitudinal bars can be counterbored (11a) to accommodate the heads.
Patent IL-118103-A0 (IL)
Title: Compositions and methods for detecting and treating acquired immunodeficiency syndrome
IPC: A61K39/00
Filed: 1996-05-01
Abstract: This invention relates to the area of immunology and virology, and specifically relates to compositions obtainable from mammalian thymus cells which are useful as diagnostics, vaccines, and therapeutics for human immunodeficiency virus (HIV) infection and related diseases such as acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). The diagnostic, vaccination, and therapeutic methods, and devices, using these compositions are also disclosed. <IMAGE>
Patent IL-124474-A0 (IL)
Title: Coated milling insert and method of making it
IPC: C22C29/08
Filed: 1996-11-29
Abstract: A coated milling insert particularly useful for milling in low and medium alloyed steels with or without raw surface zones during wet or dry conditions. The insert is characterized by a WC-Co cemented carbide with a low content of cubic carbides and a highly W alloyed binder phase and a coating including an inner layer of TiC<SUB>x</SUB>N<SUB>y</SUB>O<SUB>z </SUB>with columnar grains, a layer of kappa-Al<SUB>2</SUB>O<SUB>3 </SUB>and, preferably, a top layer of TiN. The layers are deposited by using CVD methods.
Patent IL-126477-A0 (IL)
Title: Pharmaceutical controlled release tablets containing a carrier based on cross-linked amylose and hydroxypropyl methylcellulose
IPC: A61K9/28
Filed: 1997-04-04
Abstract: Disclosed is a pharmaceutical controlled release tablet containing an active ingredient in combination with a carrier made of cross-linked amylose in which hydroxymethylpropylcellulose (HPMC) with a viscosity higher than or equal to 4000 cps is added as an adjuvant. The addition of HPMC to the tablet permits to control the effect of enzymes, and more particular alpha-amylase present in the intestinal medium, on the cross-linked amylose used as a carrier, and thus to reduce the dependence of the kinetics of release upon the concentration of enzymes present in the medium.
Patent IL-128230-A0 (IL)
Title: Method of screening active compounds
IPC: G01Q60/20
Filed: 1997-07-30
Abstract: Verfahren zum Wirkstoff-Screening, wobei man den Wirkstoff über die mittels einer rasteroptischen Nahfeldmikroskopiervorrichtung (SNOM-Vorrichtung) beobachtbare Änderung eines Signals (S) nachweist, sowie dafür geeignete Einrichtung, umfassend die SNOM-Vorrichtung, eine Einzel- oder Mehrfachprobenaufnahmevorrichtung und eine Steuereinrichtung.
Patent IL-134647-A0 (IL)
Title: Tie receptor tyrosine kinase ligand homologues
IPC: C12N1/19
Filed: 1998-09-14
Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 and NL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
Patent IL-156513-A0 (IL)
Title: Method and apparatus for manufacturing polymer fiber shells via electrospinning
IPC: D01D5/08
Filed: 2001-12-17
Abstract: An apparatus for forming a tubular structure from a liquefied polymer, the apparatus comprising: (a) a dispenser for dispensing the liquefied polymer; (b) a precipitation electrode being at a first potential relative to the dispenser, the precipitation electrode being designed and constructed for generating a polymeric shell thereupon; and (c) a mechanism for increasing a local density of the polymeric shell in a plurality of predetermined sub-regions of the polymeric shell, thereby to provide a tubular structure having an alternating density in a longitudinal direction.
Patent IL-163951-A0 (IL)
Title: New heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine
IPC: A61P17/02
Filed: 2003-04-01
Abstract: We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases.
Patent IL-165938-A0 (IL)
Title: Controlled loudness of speech in signals that contain speech and other types of audio material
IPC: H03G5/16
Filed: 2004-12-22
Abstract: Mechanisms are known that allow receivers to control loudness of speech in broadcast signals but these mechanisms require an estimate of speech loudness be inserted into the signal. Disclosed techniques provide improved estimates of loudness. According to one implementation, an indication of the loudness of an audio signal containing speech and other types of audio material is obtained by classifying segments of audio information as either speech or non-speech. The loudness of the speech segments is estimated and this estimate is used to derive the indication of loudness. The indication of loudness maybe used to control audio signal levels so that variations in loudness of speech between different programs is reduced. A preferred method for classifying speech segments is described.