baber/WOPTO huggingface dataset:
Patent NZ-331736-A (NZ)
Title: Use of photoactive green porphyrins combined with light to destroy undesired tissue
Inventor: STRONG H ANDREW
IPC: A61K41/00
Filed: 1997-02-25
Abstract: A formulation of green porphyrins as described in Fig.1A to 1F as an effective photoactive agent to improve visual acuity upon irradiation with light absorbed by the photoactive agent after administration and localisation of the agent in the eye of a human subject. The side groups are defined as follows for Fig.1A to 1F: R1 and R2 is selected from C2-6carbalkoxyl, C1-6alkyl, C6-10arylsulfonyl, CN or -CONR5CO; R5 is selected from C6-10aryl or C1-6alkyl; R3 is selected from carboxyl, C2-6carboxyalkyl or a salt, amide, ester or acyl hydrazone or C1-6alkyl; R4 is selected from -CH=CH2 or -CH(OR4')CH3; R4' is selected from H, or C1-6alkyl optional substituted with a hydrophilic substituent. Photodynamic therapy (PDT) of conditions of the eye, especially those conditions characterised by unwanted neovasculature, such as age-related macular degeneration, results in enhanced visual acuity for treated subjects. The formulation includes any pharmaceutical excipient, in combination with a photoactive agent. The preferred pharmaceutical excipient are liposomes, as the formulation is able to selectively deliver the green porphyrins to the desired site. The irradiation occurs at an irradiance of 600 mW/cm2 to provide a total fluence of 50 J/cm2 to 150 J/cm2.
Patent NZ-505322-A (NZ)
Title: Protein expression in baculovirus vector expression systems using low multiplicity of infection
Inventor: KRETZDORN DIETMAR
IPC: C07K14/18
Filed: 1998-12-17
Abstract: A method to produce a vaccine which comprises classical swine fever virus E2 protein or antigenic fragments thereof comprising growing insect cells in growth medium in a culture vessel, infecting the cells with an inoculum of a recombinant baculovirus encoding the protein or fragments thereof with a multiplicity of infection of between 0.0001 and 0.01, incubating the cells until 50-100% of the cells show cytopathic effect, removing cell material and formulating the vaccine.
Patent NZ-511113-A (NZ)
Title: Adjuvant systems containing an immunostimulant absorbed on to a metal salt particle and vaccines thereof
Inventor: GARCON NATHALIE
IPC: A61K39/145
Filed: 1999-10-08
Abstract: An adjuvant composition comprises an immunostimulant adsorbed onto a metallic salt particle provided that metallic salt particle is free of other antigens and the immunostimulant is not a saponin derived from the bark of Quillaja Saponaria Molina. The immunostimulant can be a monophosphoryl lipid A and the metallic salt can be a phosphate or a hydroxide.  The adjuvant composition is used in a vaccine composition containing an antigen.
Patent NZ-518627-A (NZ)
Title: Powered axial driving tool with front plate of nosepiece being movable to an interim deflecting position
Inventor: DRISCOLL PATRICK J
IPC: B25C1/08
Filed: 2002-04-29
Abstract: Front plate 26 is pivotally movable relative  to  back plate  24  to an interim deflecting position between  closed and open positions.
Patent NZ-525224-A (NZ)
Title: Anhydrous dentifrice formulations for the delivery of incompatible ingredients
Inventor: XU JIN
IPC: A61Q11/00
Filed: 2001-10-10
Abstract: A composition for reducing dentinal hypersensitivity and demineralising exposed dentinal surface and open dentinal tubules, comprising a non-aqueous carrier and a desensitizing amount of a desensitizing/demineralising agent, which consists of a water soluble calcium salt and an incompatible ingredient such as a water-soluble silicate that would otherwise react with the calcium salt. Upon contact with saliva when applied to an oral cavity, the desensitizing/demineralising is then formed in situ by the reaction between the calcium salt and the incompatible ingredient, thereby demineralising exposed dentinal surface and open dentinal tubules.
Patent NZ-533306-A (NZ)
Title: Circular four player chess system
Inventor: BRADLEY PAUL STUART
Filed: 2004-06-22
Abstract: Circular four player chess system comprising a board which geometrically transforms the squares of a standard chess board, doubling the number of squares and arranging them in a circle with 32 sectors across 4 lanes. Four separate sets of chess pieces are positioned in 4 by 4 blocks equidistantly around the circle. The sets of chess pieces are respectively coloured red, black, yellow and green. The rules comprise a modification of the standard rules of chess.
Patent NZ-535516-A (NZ)
Title: Inhibitors of nucleoside phosphorylases and nucleosidases
Inventor: FURNEAUX RICHARD HUBERT
Filed: 2003-03-25
Abstract: Disclosed are compounds of the general formula (I) which are inhibitors of 5'-methylthioadenosine phosphorylases and 5'-methylthioadenosine nucleosidases (MTAP and MTAN), and the use of these compounds in pharmaceutical compositions for the treatment of diseases and infections including cancer, bacterial infections and parasitic infections.
Patent NZ-537606-A (NZ)
Title: Indole-2-sulphur derivatives and their use to treat prostaglandin D2 mediated diseases
Inventor: BONNERT ROGER
IPC: A61K31/404
Filed: 2003-07-15
Abstract: Compounds of formula (I) are described wherein: n represents 1 or 2; R1 is one or more substituents independently selected from halogen, CN, nitro, SO2R4, OR4, SR4, SOR4,SO2NRSR6, CONR5R6, NR5R6, NR9SO2R4, NR9CO2R4, NR9COR4, aryl, heteroaryl, C2-C6 alkenyl, C2-C6 alkynyl or C1-6alkyl, the latter five groups being optionally substituted by one or more substituents independently selected from halogen, OR7 and NR8R9, NR8R9, S(O)xR7 where x is 0,1 or 2; R2 is hydrogen, halogen, CN,SO2R4 or CONR5R6, COR4 or C1-7alkyl, the latter group being optionally substituted by one or more substituents independently selected from halogen atoms, OR8 and NR5R6, S(O)xR7 where x is 0,1 or 2; R3 is aryl or a 5-7 membered aromatic ring containing one or more heteroatoms selected from N, S and O, each of which is optionally substituted by one or more substituents independently selected from halogen, CN, nitro, SO2R4, OH, OR4, SR4,SOR4, SO2NR5R6, CONR5R6, NR5R6, NR9SO2R4, NR9CO2R4, NR9COR4, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl, the latter three groups being optionally substituted by one or more substituents independently selected from halogen atoms, OR and NR8R9, S(O)xR7 where x is 0,1 or 2; R4 represents aryl, heteroaryl, or C1-C6 alkyl, all of which may be optionally substituted by one or more substituents independently selected from halogen atoms, aryl, heteroaryl, OR10 and NR11R12S(O)xR13 (where x = 0,1 or 2), CONR14R15, NR14COR15, SO2NR14R15, NR14SO2R15, CN, nitro; R5 and R6 independently represent a hydrogen atom, a C1-C6 alkyl group, an aryl, or a heteroaryl, the latter three of which may be optionally substituted by one or more substituents independently selected from halogen atoms, aryl, OR13 and NR14R15, CONR14R15, NR14COR15, SO2NR14R15, NR14SO2R15, CN, nitro; or R5 and R6 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from O, S(0)x where x is 0, 1 or 2, NR16, and the ring itself optionally substituted by C1-C3 alkyl; R7and R13 independently represent a C1-C6 alkyl group, an aryl or heteroaryl group all of which may be optionally substituted by halogen atoms; R8 represents a hydrogen atom, C(O)R9, C1-C6alkyl (optionally substituted by halogen atoms, aryl or heteraryl groups, both of which may also be optionally substituted by one or more fluorine atoms); an aryl or a heteroaryl group, which may be optionally substituted by one or more halogen atoms; each of R9, R10, R11, R12, R14, R15, independently represents a hydrogen atom, C1-C6 alkyl, an aryl or a heteroaryl group (all of which may be optionally substituted by one or more halogen atoms); and R16 is hydrogen, C1-4alkyl, -C(O)C1-C4alkyl, C(O)YC1-C4alkyl, Y is O or NR7 or a pharmaceutically acceptable salt or solvate thereof. The compounds can be used in a medicament for treating a disease mediated by prostaglandin D2, such as asthma or rhinitis. Also described is a process for preparing the compound.
Patent NZ-540912-A (NZ)
Title: An hand orthosis including a hand part, a thumb part and a forearm part, with a flexible connection which draws a user's thumb toward their index finger when the wrist is extended
Inventor: KING MARCUS JAMES
Filed: 2005-06-23
Abstract: A hand orthosis comprises a thumb part 1 attachable to a user's thumb, a hand part 6 fittable around a user's hand between the thumb and knuckles, a forearm part 7 fittable to a user's forearm above the hand, and a flexible connecting element 10 connected at one end to the thumb part 1, movably coupled to the hand part 6 and connected at another end to the forearm part 7. When the orthosis is fitted to a user, extension of the user's wrist draws the user's thumb towards the user's index finger to form a grip.
Patent NZ-546522-A (NZ)
Title: Combinations of potassium channel openers and sodium channel inhibitors or active substances influencing sodium channels in order to treat painful conditions
Inventor: HERMANN ROBERT
IPC: A61P25/06
Filed: 2004-10-18
Abstract: Disclosed is the use of potassium channel openers such as flupirtine in combination with sodium channel inhibiting substances selected from the group comprising tolperisone or its analogs eperisone or silperisone, or riluzole, propafenone, lidocaine, flecainide, metixene or their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of painful conditions associated with elevated muscle tone such as neuralgias, arthritis, chronic or episodic tension headache, lower spastic paraparesis syndrome, lower paraspasm, transverse myelitis , multiple sclerosis , hereditary inferior spastic paraplegia (Stuempel's paraplegia), impairments of the spinal blood circulation, cerebral paralysis with lower spastic paresis, tetraparesis associated with cervical myelopathy, cervical brachialgia, vertebral dysplasia or Parkinson's disease.
Patent NZ-548071-A (NZ)
Title: 4-Aryl-pyrazolyl derivatives in the form of drugs for treating acute or chronic neuronal regressions
Inventor: BOHME ANDREES
IPC: A61K31/55
Filed: 2004-11-22
Abstract: Disclosed are 4-aryl-pyrazole compounds of formula (I) which are useful as alpha7 nicotinic receptors modulators, in which A if it is present, is an alkyl radical, an alkenyl radical, an alkynyl radical, a cycloalkyl radical or a cycloalkenyl radical; R1 is NR6R7, azacycloalkyl, azacycloalkenyl, azabicycloalkyl or an azabicycloalkenyl group; wherein A-R1 is such that the nitrogen of R1 and in the 1-position of the pyrazole are separated by at least two carbon atoms; R3 is a radical selected from H, halogen, OH, SH, NH-2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb , NHC(O)Ra, NHC(S)Ra or NHSO2Ra; R4 is an optionally substituted aryl or heteroaryl radical; R5 is a radical selected from H, halogen, CF3, CHF2, CH2F, alkyl, cycloalkyl; wherein the other substituents are as disclosed herein. Also disclosed is the use of at least one compound as defined above, for preparing a medicinal product for use in the treatment, prevention, diagnosis, monitoring of the evolution of psychiatric disorders or diseases or neurological disorders or diseases of the central nervous system involving an impairment of cognitive functions or of the processing of sensory information (diseases such as Alzheimer's disease or schizophrenia).
Patent NZ-549265-A (NZ)
Title: A method of preventing or reducing bending of firedoors by inclusion of fibers that will degrade reducing tension inside the door
Inventor: KORSGAARD ANDERS
IPC: E06B3/263
Filed: 2005-03-04
Abstract: A method of preventing or reducing temperature gradient caused bending of a structural element (60) made of a material capable of withstanding heating to a specific temperature for an extended period of time is disclosed. The structural element (60) is connected to an adjacent supporting structural element through a high temperature resistant supporting body. The high temperature resistant supporting body is a pultruded profiled body (20) including a solidified high temperature resistant resin and reinforcing fibres (26IV). The fibres are chosen to exhibit high strength and high stiffness at a low temperature and a reduced strength and a reduced stiffness when exposed to a higher specific temperature. When exposed to such temperatures the profiled body fibres deteriorate in a known manor, allowing for expansion of the structural element it is attached to, limiting stress and warping of the structural element. An example of such a structural element may be a fire door.
Patent NZ-551962-A (NZ)
Title: Compression sleeve having air conduit
Inventor: MEYER ANN P
Filed: 2006-12-11
Abstract: A compression sleeve is described as having a first sheet, a second sheet attached to said first sheet and defining at least one inflatable section, and at least one conduit disposed in the at least one of said inflatable sections.
Patent NZ-556322-A (NZ)
Title: A cladding system including tongue and groove boards and intervening extrusion
Inventor: PARKER JEREMY JOSEPH
Filed: 2007-07-04
Abstract: A cladding system includes an upper board 3 with a bottom edge recess 7 and a lower board 2 with an upper edge tongue 4, and an extrusion 1 with an external face 11, a lower board engaging portion 5 receiving the protruding tongue 4 of the lower board and an upper board engaging portion in the form of a tongue 6 engaging the recess in the bottom of the upper board. The extrusion is mounted on the lower board, attached to the framing using a fastener 9 through the upper projection 8 which also serves to provide support 10 for the upper board, and then the upper board is engaged with the extrusion, and so on, to clad the wall.
Patent NZ-561175-A (NZ)
Title: Solar water heating assemblies that connect a plurality of heat absorbing pipes to a manifold
Inventor: BULL ROYSTON DOUGLAS
Filed: 2007-09-04
Abstract: A clamping structure for clamping an array of small bore tubing elements that are part of a solar water heating assembly is disclosed. The clamping structure is clamped over an array of nozzle spigots (20) that extend laterally from a manifold (11) section. The clamping structure includes a first and a second clamping member (13, 14) each defining a first clamping surface (27, 28) having a plurality of recessed regions (29, 30) formed therein. In use the recessed regions are arranged in complementary pairs. When the clamping surfaces (27, 28) are arranged facing one another they capture and retain a portion of separate small bore tubing elements between each of the pairs of complementary recessed regions (29, 30) and an outer surface of a the nozzle spigot (20). This retains the small bore tubing pressed onto the spigots (20) within the clamping structure and secures them to the manifold (11).
Patent NZ-563203-A (NZ)
Title: Aromatic pocket tear tape for cigarette pack
Inventor: PHAM XUAN
IPC: B65D85/10
Filed: 2006-06-09
Abstract: A cigarette package is disclosed which comprises a film wrapped around the package, a label having multiple layers encapsulating an aromatic substance, adhesive bonding the label to the film, and a tear strip. The tear strip when pulled slices through the film and the label thereby releasing the aromatic substance from the label.
Patent NZ-563968-A (NZ)
Title: Drink dispensing system
Inventor: COLLINS TESS
IPC: B67D3/02
Filed: 2006-06-28
Abstract: A refillable drink 30 container system comprising a) a drink 30 dispensing unit with a filling tap 22 located within a cavity 12, and b) a refillable drink 30 container having an opening for the passage of liquid there through, at least a portion of the container being adapted to enter the cavity 12 and engage with the dispensing unit such that the opening in the container is positioned near the filling tap 22 to allow liquid to be dispensed from the filling tap 22 into the drink 30 container, wherein the engagement between the dispensing unit and the container prevents contact between the opening of the container and the filling tap.
Patent NZ-567593-A (NZ)
Title: Ice harvest prevention mechanism in a refrigerator
Inventor: MAGLINGER FRANK WESTON
Filed: 2006-11-03
Abstract: An ice harvesting prevention mechanism (20), including an actuator (30), is provided for an ice maker (22). The ice maker is arranged to make, harvest and dispense ice to an ice bucket (26) located in an ice receiving position. An ice harvesting prevention device (20) is arranged to prevent dispensing of ice in a first position of the actuator and to permit dispensing of ice in a second position of the actuator. The ice bucket itself (26), or a movable button (50) carried on the ice bucket, may engage the actuator, when the ice bucket is placed in the ice receiving position, to move the actuator from the first position to the second position. The button may be moved to an "off" position to prevent engagement with the actuator, thereby preventing dispensing of ice when the ice bucket is in the ice receiving position. (62) (62) Divided out of 551087
Patent NZ-584268-A (NZ)
Title: Device and method for opening a covered optical cable without interfering with the optical wires
Inventor: MULLANEY JULIAN
IPC: G02B6/245
Filed: 2008-08-25
Abstract: Disclosed is an apparatus (100) for accessing a length of a selected one or more of a plurality of optical fibers within an outer protective jacket of a cable (110) including the plurality of optical fibers and at least one strength member extending longitudinally therein include a cable positioning fixture (105). The cable positioning fixture is configured to receive a portion of the cable therein and to establish a desired orientation of the portion of the cable in the fixture relative to the at least one strength member therein while a cutting member (130) removes a scalloped segment from the outer protective jacket.
Patent NZ-585398-A (NZ)
Title: Assigning values to pixels in mosaic image based on values corresponding pixels in captured images determined using reverse ray-tracing
Inventor: ACREE ELAINE
IPC: G06V20/13
Filed: 2008-11-14
Abstract: Disclosed is a system for generating a mosaic pixelated digital image from a plurality of acquired pixelated images, each acquired image being of a portion of a surface of earth. The acquired images are acquired by a digital camera while the camera translates above the surface of the earth; the camera having a respective geo-referenced location and a respective orientation when each acquired image is acquired. The system is comprised of a computer processor programmed to use a mathematical model of a surface shape of the Earth and 3-D ray tracing, from a model of the digital camera to the model of the surface of the earth, to determine a plurality of locations on the surface of the Earth corresponding to respective locations in the plurality of acquired images. This determination is then used to determine an extent to which the surface of the Earth was imaged by the plurality of acquired images. The determination is also used to determine boundaries of the mosaic image based at least in part on the determined extent to which the surface of the Earth was imaged. For each pixel within the determined boundaries of the mosaic image the processor uses the mathematical model of the shape of the Earth and reverse 3-D ray tracing, from the model of the surface of the earth to a model of an image plane of the digital camera, in each of at least one candidate image of the plurality of acquired images. The processor then determines a candidate pixel in the candidate image that geographically corresponds to the pixel in the mosaic image, based at least in part on the location and the orientation of the camera proximate a time at which the camera acquired the candidate image, thereby determining at least one candidate pixel. A value is then assigned to the pixel in the mosaic image, based on a value of the determined at least one candidate pixel and then the assigned values of the pixels in the mosaic image are stored in a memory.
Patent NZ-590863-A (NZ)
Title: Anti-hepcidin-25 selective antibodies and uses thereof
Inventor: LEUNG DONMIENNE DOEN MUN
IPC: A61K39/395
Filed: 2009-07-29
Abstract: Disclosed is a monoclonal antibody that selectively binds human hepcidin-25 consisting of the amino acid sequence shown in SEQ ID NO:1 and wherein the 5 antibody comprises six complementarity determining regions (CDRs) selected from the group consisting of LCDR1, LCDR2, LCDR3, HCDR1, HCDR2, and HCDR3 having the amino acid sequences as shown in SEQ ID NOs: 17, 18, 19, 42, 43 and 44, respectively. Also disclosed is the use of the antibody for the manufacture of a medicament for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human subject.
Patent NZ-591128-A (NZ)
Title: Switches for microfluidic systems
Inventor: SHEN WEI
IPC: B01L3/00
Filed: 2009-08-10
Abstract: 591128 A microfluidic system to allow low-cost biological analysis and indicator devices. The microfluidic system includes a cellulosic substrate in sheet form, at least one hydrophilic microfluidic channel supported on a surface of the substrate, and at least one functional component formed as part of the substrate provides a switch for controlling fluid flow along the microfluidic channel. The functional component is formed by at least one cut provided within the substrate for defining a portion of the substrate displaceable relative to the remainder of the substrate, the substrate portion supporting at least part of the microfluidic channel. Alternatively the functional component is formed by at least one cut provided within the substrate and a strip of material passing through the cut to form a sliding switch, wherein at least part of the microfluidic channel is supported on the strip. A plurality of switches can be included, the switches controlling the flow of a reactant from a dosing zone to at least one detection zone.
Patent NZ-598278-A (NZ)
Title: Process for preparing biphenyl imidazole compounds
Inventor: ZHANG WEIJIANG
IPC: A61P9/12
Filed: 2010-09-28
Abstract: 598278 Provided are processes for preparing intermediates of formula (I), (II) and (III) where R1, R2, R3, R4 and P are as defined in the specification, useful for preparing compounds of the formula (IV) where R1, R2 and R3 are as defined in the specification. Further provided are crystalline 4’-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3’-fluorobiphenyl-2-carboxylic acid t-butyl ester, crystalline 4’-{ 5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl} -3’-fluorobiphenyl-2-carboxylic acid and a compound of formula (3) where R1, R2 and P are as defined in the specification. Further provided are compounds of formula (I), (II), (III) when prepared by the processes described.
Patent NZ-599945-A (NZ)
Title: Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
Inventor: MASCITTI VINCENT
IPC: A61K31/35
Filed: 2010-10-21
Abstract: 599945 Compounds of Formula (A) and (B) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors). Examples of the compounds are: (1S,2S,3S,4R,5S)-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol; (1S,2S ,3S ,4R,5S )-5-{ 4-chloro-3-[( 4-ethoxy-phenyl)-hydroxy-methyl]phenyl} -1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol and Acetic acid 2-{ 4-[2-chloro-5-((1 S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]oct-5-yl)-benzyl]-phenoxy} -ethyl ester.