Patent SG-11201900794P-A (SG)
Title: Multivalent pneumococcal polysaccharide-protein conjugate composition
Inventor: AN KYUNGJUN
IPC: A61K39/39
Filed: 2017-08-04
Abstract: 1 N O cc O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIPO I PCT IiiimmounnotioloomoimmomomomovoimIE (10) International Publication Number WO 2018/027126 Al (51) International Patent Classification: A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/09 (2006.01) A61K 39/39 (2006.01) A61K 39/116 (2006.01) (21) International Application Number: PCT/US2017/045483 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/371,553 05 August 2016 (05.08.2016) US 62/525,945 28 June 2017 (28.06.2017) US (71) Applicants: SANOFI PASTEUR, INC. [US/US]; 1 Dis- covery Drive, Swiftwater, PA 18730 (US). SK CHEMI- CALS CO., LTD. [KR/KR]; Life Science Biz, 310, Pangyo-ro, Seongnam-si, Gyeonggi-do, 13494 (KR). (72) Inventors: AN, Kyungjun; 302, 8-19, Bangbae-ro 20- gil, Seocho-gu, Seoul, 06684 (KR). CHOI, Wooyoung; 805-1703, 52, Pungdeokcheon-ro, Suji-gu, Yongin-si, Gyeonggi-do, 16843 (KR). HAM, Dongsoo; 113-505, 373, Gwongwang-ro, Paldal-gu, Suwon-shi, Gyeonggi-do, 16493 (KR). KIM, Hun; 6114-2903, 76, Central Town- ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16505 (KR). SHIN, Jinhwan; 233-1201, 24, Jungdae-ro, Songpa-gu, Seoul, 05834 (KR). HOPFER, Robert; c/o Sanofi Pas- teur, 1 Discovery Drive, Swiftwater, PA 18730 (US). KENSINGER, Richard, D.; c/o Sanofi Pasteur, 1 Dis- covery Drive, Swiftwater, PA 18730 (US). KYAW, Moe; c/o Sanofi Pasteur, 1 Discovery Drive, Swiftwater, PA 18730 (US). DESAUZIERS, Eric; c/o Sanofi Pateur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). EL GUERCHE SEBLAIN, Clotilde; c/o Sanofi Pasteur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). TA- LAGA, Philippe; c/o Sanofi Pasteur SA, 2, Avenue Pont Pasteur, 69367 Lyon Cedex 07 (FR). (54) Title: MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION Mono-conjugate of Serotype 8 F- 2 0 350 300 250 200 150 100 50 0 8-1 (0.5 big) 8-1 (2.2 mg) 8-1 (8.8 iug) FIG. 1A (57) : Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 20 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, wherein two of the capsular polysaccharides are conjugated to tetanus toxoid and the remaining capsular polysaccharides are conjugated to CRMig7, and wherein the two capsular polysaccharides that are conjugated to tetanus toxoid are selected from the group consisting of serotypes 1, 3, and 5. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject. [Continued on next page] WO 2018/027126 Al MIDEDIMOMMIDIIMERIONMOIDEEDHOHIMOVOIMIE (74) Agent: DONALDSON, Timothy, B.; MH2 Technology Law Group, 1951 Kidwell Drive, Suite 550, Tysons Corner, VA 22182 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))