baber/WOPTO huggingface dataset:
Patent CA-2213249-A1 (CA)
Inventor: YASUDA NOBUYUKI
IPC: C07D401/06
Filed: 1996-02-16
Abstract: L'invention concerne un procédé de préparation de composés 3-arylindoline représentés par la formule générale (2). Dans cette formule, R?1¿ représente un phényle ou un hétérocycle aromatique, pouvant être substitué, et R?2¿ représente un hydrogène, un halo, un alkyle inférieur, un hydroxy, un alcoxy inférieur, un carbamoyle ou un alcoxycarbamoyle inférieur. Ces composés sont utiles pour préparer des antagonistes des récepteurs du type 3 de la 5-HT, que sont les composés 1-acyl-3-arylindoline représentés par la formule générale (1), dans laquelle R?1¿ et R?2¿ sont définis ci-dessus et R?3¿ a la formule (a) ou (b). Dans ce procédé on utilise un composé 1-acyl-3-arylindole, obtenu en fixant un groupe électronégatif éliminable en position 1 d'un composé 3-arylindole, par l'acylation de ce composé avec un acide organique tel qu'un acide carboxylique ou un acide sulfonique, puis en effectuant une réduction catalytique modérée dans des conditions neutres ou légèrement acides pour donner un composé 1-acyl-3-arylindoline. Un composé 1-acyl-3-arylindole optiquement actif est obtenu en acylant un composé 3-arylindole avec un acide organique tel qu'un acide carboxylique ou un acide sulfonique, etc., optiquement actif, pour finalement obtenir un composé 1-acyl-3-arylindoline, par une réduction catalytique à haute sélectivité.
Patent CA-2215233-A1 (CA)
Title: Terminal carboxy or tetrazole groups containing dialkyl ethers
Inventor: SALTIEL ALAN ROBERT
IPC: A61K31/194
Filed: 1996-02-05
Abstract: Dialkyl ethers having terminal carboxy or tetrazole groups lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
Patent CA-2216157-A1 (CA)
Title: Scouring compositions safe for surfaces
Inventor: ORMEROD RALEIGH CLAIR IV
IPC: C11D3/14
Filed: 1996-03-27
Abstract: Hard-surface scouring cleansers contain surfactant, water soluble abrasive/alkal inity mixture of water soluble carbonate and bicarbonate, preferably bleach, optional buffer and/or minors. Such compositions combine the stain and soil removal properties of a strong active chlorine bleaching agent and bleach-stable surfactant in an abrasi ve cleanser having desirable surface safety.
Patent CA-2217426-A1 (CA)
Inventor: MILTENBERGER MICHAEL
IPC: B60R21/20
Filed: 1997-10-27
Abstract: Abstract of the disclosure An airbag module for motor vehicle steering wheels is proposed, having a gas generator (1), a folded a covering (4) which is connected to the generator support (3) at the edges and has predetermined breaking points (8) and also having a retaining plate (5) for fastening the airbag (2) on the generator support (3), all the elements mentioned forming a one-part structural unit which can be connected to a steering wheel.             To be able to adapt the volume inside such an airbag module to various volume requirements, without losing the abutment formed for the covering (4) by the folded together airbag (2), it is proposed that there be arranged between the gas generator (1) and the folded together airbag (2) a displacement element (6,7) which fills a predetermined proportion of the volume available between the gas generator (1), the generator support (3) and the covering (4) for the folded together airbag (2).       Fig. 1
Patent CA-2220156-A1 (CA)
Inventor: NADLER JERRY L
IPC: A61K38/08
Filed: 1996-05-03
Abstract: Selon la présente invention, l'on a obtenu des indications de la présence d'une 12-lipoxygénase (12-LO) du type leucocytaire humain et du rôle qu'elle joue dans la pathogenèse de plusieurs états ou processus pathologiques importants, dont l'athérosclérose, le cancer du sein, les maladies inflammatoires et auto-immunes, les affections rénales et vasculaires diabétiques et l'insulinorésistance. La médiation, ainsi que l'inhibition, de l'activation enzymatique ou de l'expression de la 12-LO leucocytaire constitue un nouveau traitement permettant de prévenir ou de soigner ces états pathologiques.
Patent CA-2220979-A1 (CA)
Inventor: SOPPET DANIEL R
IPC: C07K14/705
Filed: 1995-06-05
Abstract: La présente invention concerne des récepteurs polypeptidiques couplés par la protéine G humaine et l'ADN (ARN) codant de tels polypeptides, ainsi qu'un procédé de production de ces polypeptides par des techniques de recombinaison. Elle concerne également des procédés d'utilisation desdits polypeptides pour l'identification d'antagonistes et d'agonistes de ces polypeptides ainsi que des procédés d'application thérapeutique des agonistes et des antagonistes dans le traitement de la sous-expression et de la surexpression des récepteurs polypeptidiques couplés par la protéine G. L'invention concerne en outre des méthodes de diagnostic permettant de détecter une mutation dans les séquences d'acide nucléique des récepteurs couplés par la protéine G, de même qu'une modification de la concentration de la forme soluble des récepteurs.
Patent CA-2221109-A1 (CA)
Inventor: TRIGIANTE GIUSEPPE
IPC: C11D3/28
Filed: 1996-04-19
Abstract: The present invention discloses a process for the manufacture of liquid aqueous bleaching compositions comprising hypochlorite, a strong source of alkalinity and water, said process comprising the steps of: mixing said alkali metal hypochlorite, said strong source of alkalinity and said water; adding a precipitating agent, or mixtures thereof; and thereafter separating the precipitates formed from said composition. The compositions provided by the process according the present invention are substantially free of heavy metal ions, thereby providing improved whiteness performance and/or fabric safety performance.
Patent CA-2222926-A1 (CA)
Title: Electrochemiluminescent monitoring of compounds
Inventor: DONG LIWEN
IPC: C07D499/26
Filed: 1996-06-07
Abstract: The present invention provides detectable compounds comprising a chemically-transformable first compound covalently linked to an electrochemiluminescent compound. These compounds are useful in processes and kits that monitor the status of the first compound and derive information from the monitoring. The figure shows a proposed ECL mechanism depicting reaction steps associated with the use of TPA as a nonconjugated reductant.
Patent CA-2224907-A1 (CA)
Title: Methods and means for targeted gene delivery
Inventor: VALERIO DOMENICO
IPC: A61K47/48
Filed: 1996-07-25
Abstract: The present invention provides a method of producing viral gene delivery vehicles which can be transferred to preselected cell types by using targeting conjugates. The gene delivery vehicules comprise: 1) the gene of interest (to be delivered); 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be made unable to bind to their natural receptor on the cell. The targeting conjugates are composed of the counterpart member of the specific binding pair linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be for example an immunoglobulin binding moiety (e.g. capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The outer membrane or capsid of the virus may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the high affinity of the binding pair and to the inability of the gene delivery vehicle to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can easily be achievied by the use of various adequate targeting conjugates.
Patent CA-2226459-A1 (CA)
Title: Resin composition and usage thereof
Inventor: ISHIURA KAZUSHIGE
IPC: C08L23/02
Filed: 1998-01-07
Abstract: A resin composition comprising (A) a polyolefin resin, (B) a vinyl alcohol copolymer and (C') a block copolymer composed of a polymer block of an aromatic vinyl compound and an isobutylenic polymer block, the weight ratio of (A) to (B) ranging from 100/10 to 100/1000 and the weight ratio of (C') to [(A)+(B)] ranging from 5/100 to 1000/100 is a flexible resin material having high gas barrier properties, good heat resistance and good moldability or formability so that it is useful as a material for various molded or formed articles. In addition, a closure (cap, stopper or the like) for containers or a sealing element (packing element) for the closure for containers which is formed of a resin composition comprising (A) a polyolefin resin, (B) a vinyl alcohol copolymer and (C) an elastomer, the weight ratio of (A) to (B) ranging from 100/10 to 100/1000 and the weight ratio of (C) to [(A)+(B)] ranging from 5/100 to 100/100 has good hermetical sealing properties and good mountability onto (or within) a container and is also excellent in the long-term shelf stability of contents.
Patent CA-2226632-A1 (CA)
Inventor: PUTMAN HUGH M
IPC: C10G45/02
Filed: 1996-06-27
Abstract: A process for the hydrodesulfurization of petroleum streams is disclosed wherein the sulfur containing petroleum stream is contacted along with hydrogen at a partial pressure of less than 70 psig in a distillation column reactor containing a hydrodesulfurization catalyst in the form of a catalytic distillation structure.
Patent CA-2231180-A1 (CA)
Title: Trolley car for material handling train
Inventor: STRAND JOHN
IPC: B07C3/08
Filed: 1996-09-05
Abstract: An automated material handling system utilizing one or more train-type guided vehicles (12) moving along a rail (10) with each train including a locomotive (14) pulling a plurality of trolleys (16). Each trolley includes a tiltable tray (26), an onboard CPU (44), and onboard sensors (94a, 94b, 96, 98) for sensing information with respect to the product (22) being carried by the tray. The sensed information is transmitted to the CPU of the trolley where it is stored and also transmitted to a CPU in the locomotive. The locomotive CPU  (107) is in radio frequency contact with an off-track dispatch computer (19) controlling the overall operation of the material handling system. The CPU of each trolley is also in infrared communication with local CPU's positioned at unloading stations so that the CPU of each car may receive information by infrared transmission from local CPU's.
Patent CA-2235466-A1 (CA)
Title: Eyeglass appliance having auxiliary frame
Inventor: CHAO DAVID YINKAI
IPC: G02C9/00
Filed: 1998-04-24
Abstract: An eyeglass appliance includes a primary frame having two side studs for pivotally coupling two legs thereto. An auxiliary frame for disposing in front of the primary frame includes two sides each having an extension for overlying the stud and the leg. Each of the extensions may include a magnet for engaging with another magnet mounted in the adjacent leg or with a magnetic leg and for securing the auxiliary frame to the primary frame. Each of the extensions may include a clamping member for securing to the legs without the use of magnets.
Patent CA-2237496-A1 (CA)
Inventor: DEAN DAVID L JR
IPC: G02B6/38
Filed: 1998-05-12
Abstract: An adapter assembly is provided for removably receiving two optical fiber ferrules of the type with open grooves extending longitudinally rearward of the end face of the ferrule. The assembly comprises a sleeve with an interior surface that defines a passageway therethrough sized for receiving the ends of the ferrules therein. The interior surface also defines two longitudinal grooves opposite each other that open to the passageway. A guide pin is located in each groove such that an exposed portion of the outer surface of the guide pin along the entire length of the guide pin inside the sleeve is exposed to the passageway. The exposed portion are sized and located relative to each other to slide in the ferrule grooves and operatively align the end faces of the ferrules rotationally and laterally relative to each other when the two ferrules are inserted into the sleeve.
Patent CA-2239909-A1 (CA)
Title: Use of toxin peptides and/or affinity handles for the delivering compounds into cells
Inventor: MILNE JILL C
IPC: C12N15/87
Filed: 1996-12-13
Abstract: A method and compositions for delivering a compound to the cytoplasm of a cell are disclosed. The compound to be delivered may be an antigenic compound, may be linked to a polycationic affinity handle, or both. In one of the methods disclosed, the B moiety of a toxin, such as the anthrax PA polypeptide, is also provided to enhance delivery of the compound to the cytoplasm of the cell.
Patent CA-2240991-A1 (CA)
Title: A method for recording and playing back information on magnetic strips and related reading/recording apparatus
Inventor: ZANETTI GIANCARLO
IPC: G06K11/00
Filed: 1996-10-25
Abstract: A method for recording and playing back an audio and/or video signal (and associated recording and playback apparatus, comprises: A) converting an audio and/or video signal into a first series of samples, achieved by sampling at a predetermined frequency and writing to a read/write memory (46), B) forming, by the later reading of the samples from memory at a frequency that is different from that of writing and is possibly variable, a recording on a magnetic strip (43) associated with a succession of timing marks (34) which identify recording blocks and a predetermined time T for playback of each block, C) obtaining, by reading the recording and the associated succession of timing marks, a second series of samples which are written to the memory in order, and a timing signal, D) applying the second series of samples read from the memory in an order correlated with that of writing, through a filter, to a transducer, the sampling frequency of the recording or reading of the samples from memory, which varies over time, being determined by the timing signal, in such a way that each recording block is played back in the time T.
Patent CA-2241612-A1 (CA)
Title: Mechanism for connecting printed circuit boards of separate devices
Inventor: ZELL KARL
IPC: H05K5/00
Filed: 1998-06-26
Abstract: The mechanism establishes electrical connection of two printed circuit boards of separate devices that form individual modules within a stackable module system. In order to achieve a simply constructed connection mechanism, the printed circuit boards respectively have centering or spring clips into which an adapter assembly is pluggable. The adapter assembly is thereby composed of two blade or spring clips firmly connected to one another via an adapter assembly printed circuit board, whereby the adapter assembly is surrounded by shielding covers firmly connected to one another. In the plugged condition, the adapter assemblies are conducted through housing openings in oppositely residing housing parts of the devices stacked above one another. whereby the outsides of the shielding covers contact the surrounding edges of the housing openings.
Patent CA-2244935-A1 (CA)
Inventor: ROGOLS SAUL
IPC: A23L19/18
Filed: 1998-08-12
Abstract: The present invention provides an aqueous starch enrobing slurry for coating the outer surface of a potato product having an as is solids content comprising ungelatinized starch and not less than 50% by weight rice flour and the coated potato products produced thereby.
Patent CA-2247974-A1 (CA)
Title: A security element for documents and a method for its fabrication
Inventor: DE JONGH RUDI
IPC: B42D15/10
Filed: 1998-09-23
Abstract: A document consists of a substrate (1) and a security element which comprises an optical grating. In order to enhance the copying security, the optical grating is a volume hologram (2) into which a kinetic effect has been introduced (Fig. 2).
Patent CA-2252721-A1 (CA)
Title: End fitting for sprinkler system
Inventor: DOLE DOUGLAS R
IPC: F16L17/04
Filed: 1997-04-10
Abstract: An end fitting (30) for a water supply pipe of a sprinkler system is in the form of a hollow tubular body (32) having an internal cavity which progressively decreases in cross-sectional area from an end (38) of the body (32) attached to the supply pipe (14) to an opposite end (34) of the body (32) in the manner of a convergent nozzle, in order to enhance the pressure of water available to a sprinkler head (24) attached to the fitting (30) at a position remote from the pipe end (38).
Patent CA-2253406-A1 (CA)
Inventor: WUSTROW DAVID JUERGEN
IPC: C07D413/06
Filed: 1997-05-20
Abstract: Compounds having formulae (I) or (II) wherein R1 and R2 are independently hydrogen or C1-C6 alkyl; X is N or CH; and R3 is phenyl, naphthyl, heteroaryl, substituted phenyl, substituted naphthyl or substituted heteroaryl, wherein each substituent is independently selected from halogen, C1-C6 alkoxy, C1-C6 alkyl, -CN, -CF3, or sulphonamido, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, are antagonists of dopamine D4 receptors.
Patent CA-2253598-A1 (CA)
Inventor: OLSON KENNETH G
IPC: G02B1/11
Filed: 1997-04-29
Abstract: An anti-reflective film construction contains an optically transparent polymeric film having a textured surface and an optically transparent adhesive, the film construction configured to exhibit light transmission of greater than about 70 percent and 60~ gloss measurement of between about 15 and 100. Methods of producing such film constructions and methods of reducing reflection from a surface are also described.
Patent CA-2254467-A1 (CA)
Title: Paint curing oven
Inventor: INO MASANORI
IPC: F26B3/30
Filed: 1998-11-19
Abstract: A drying oven for curing paint applied to a vehicle comprising a housing, radiant heat panel located on the side walls of the housing, a conveyor for carrying a vehicle through the housing and a convection heater unit positioned at a height below the conveyor such that heat from the convection heater is directed onto the under floor of the vehicle passing through the housing on the conveyor. In a first embodiment, the convection heater unit includes a feed pipe positioned below the conveyor and a plurality of nozzles extending from the feed pipe for directing hot air onto the under floor of the vehicle. In a second embodiment, a plurality of heat ducts are located below and to the side of the conveyor, each heat duct having an opening directed at the under floor of the vehicle on the conveyor for directing hot air onto the under floor of the vehicle.
Patent CA-2254597-A1 (CA)
Title: Synthesis of sulfoxides via selective oxidation of sulfides with a perborate or a percarbonate
Inventor: NEWALLIS PETER E
IPC: C07D285/125
Filed: 1998-11-27
Abstract: The present invention provides a process for making sulfoxides from sulfides. The process includes the step of selectively oxidizing a sulfide utilizing a perborate or a percarbonate as an oxidizing agent.
Patent CA-2259847-A1 (CA)
Inventor: WARD ANDREW MARK
IPC: B01J19/18
Filed: 1999-01-21
Abstract: A catalyst unit for use in an exothermic reaction, such as ammonia oxidation, comprises a material effective as a catalyst for said reaction having a shape conforming to a disc or cone having a plurality of radially extending corrugations. The catalyst unit may be disposed across a reactor with a start-up burner disposed above the catalyst unit and mounted for rotation about the axis of the reactor. The burner tube is pivoted and provided with means, for example a follower engaging with the upper surface of the catalyst unit, so that as the burner is rotated about the axis the burner tube pivots to maintain the burner tube a constant distance above the upper surface of the catalyst unit.
Patent CA-2260091-A1 (CA)
Inventor: BERG RONALD ARTHUR
IPC: G01N33/22
Filed: 1997-06-25
Abstract: The heating value of a sample gas is calculated by a microcontroller (12) from the heating value of a reference gas, and from flow ratios and power levels determined as the gas is combusted by a flameless combustion process. The combustible gas is mixed with a combustion supporting gas, such as air, and flowed to a body of material (26, 52) which is heated to a temperature sufficient for oxidation of the gas mixture. The size of spaces in a first embodiment of a heater device (9, 11, 25, 26) and in a second embodiment of a heater device (50) are limited to prevent formation of an open flame. In a preferred "lean mixture" embodiment, the gas-air mixture of the reference gas, and the gas-air mixture of the sample gas, respectively, are each adjusted until a selected power level of combustion at a temperature lower than the point of stoichiometric combustion is reached. In a second, "rich mixture"  embodiment, the gas-air mixture of the reference gas, and the gas-air mixture of the sample gas, respectively, are each adjusted from a "rich mixture" to reach a point of stoichiometric combustion. Based on flow rates and the selected power ratio, the heating value of the sample gas is calculated by the microcontroller (12) and output to a visual display or other output device.
Patent CA-2260637-A1 (CA)
Title: Free-flowable, directly compressible starch as binder, distinegrant and filler for compression tablets and hard gelatine capsules
Inventor: MICHAUD JACQUES LOIC MARIE
IPC: C08B30/12
Filed: 1999-02-02
Abstract: A directly compressible starch consisting in an intense white free-flowing powder showing both excellent compression profile and extremely good disintegration properties. This starch is especially designed to be used as a binder in direct compression processes where it yields very hard white tablets at relatively low compression forces. Tablets resulting from the compression of the above mentioned starch disintegrate in an aqueous medium at a very high speed and they additionally exhibit low friability pattern. This free-flowing starch also brings advantages when used as filler and binder in the filling of some hard gelatine capsules especially for these which are filled by pre-compression of the ingredients. This starch is characterised by regular and smooth partially swollen granules which can be either birefringent or non-birefringent. It can be prepared by spray-drying of a partially cooked starch.
Patent CA-2261540-A1 (CA)
Title: Method and system for detecting and determining the location of a chain jam
Inventor: MILLER MICHAEL
IPC: B65G43/02
Filed: 1999-02-15
Abstract: A method and system for detecting a condition indicative of a chain jam in a power driven endless chain are disclosed. The chain of such a system is forced into a zigzag pattern by the inclusion of deflectors at various positions along the chain pathway and the force exerted against these deflectors is measured by sensors. When a jam occurs the force on the deflectors between the location of the jam and the drive, in the direction upstream from the drive, increases, and this increase is sensed and used to actuate indicators near each of the sensors at which such an increase has occurred. The chain jam is found upstream of the furthest actuated indicator from the drive.
Patent CA-2262629-A1 (CA)
Title: Acoustic isolator for acoustic well logging tool
Inventor: ELIZONDO ENRIQUE
IPC: G10K11/16
Filed: 1997-03-10
Abstract: An acoustic well logging tool (11) is shown having a transmitter section (17) and a receiver section (19) spaced apart by a semi-rigid housing (21). The semi-rigid housing (21) includes a number of rigid tubular members (27, 29) which are joined by interlocking lobes (33, 35) which permits relative movement between the tubular members but which prevents the separation thereof. Gaps (49) between the interlocking lobes (33, 35) are filled with a connecting material which differs significantly in acoustic impedance from the material of the remainder of the housing, whereby acoustic energy passing from the transmitter section (17) along the body of the tool is delayed and attenuated.
Patent CA-2264330-A1 (CA)
Title: Silicone hydrogel polymers
Inventor: HARGISS MARCIE
IPC: C08L83/08
Filed: 1999-03-02
Abstract: A silicone hydrogel polymer prepared by curing a reaction mixture comprising a hydroxyalkylamine-functional silicone-containing monomer.