Patent FR-2857664-A1 (FR)
Title: New thiazole derivatives and their addition salts used as couplers in hair dye compositions
Inventor: MAVRO JACQUELINE
IPC: C07D277/44
Filed: 2003-07-15
Abstract: New thiazole derivatives and their addition salts with an acid or a base. The thiazole derivatives are of formula (I). [Image] R1, R2H, phenyl optionally substituted with one or more of halogen or hydroxy or 1-4C alkoxy, carboxy, mono- or dialkyl(1-4C)carboxamido or 1-4C thioether or alkyl(1- 4C)sulfonyl or sulfonic or alkylsulfoxide, alkylsulfonamido or NR13R14 or 1-4C alkyl optionally substituted with one or more hydroxy or 1-4C alkoxy or carboxy or mono- or dialkyl(1-4C)carboxamido or alkyl(1-4C)sulfonyl or sulfonic or alkylsulfoxide or alkylsulfonamido or NR13R14, 1-8C alkyl optionally substituted with one or more hydroxy or 1-2C alkoxy or carboxy or mono- or dialkyl(1-4C)carboxamido or alkyl(1- 4C)sulfonyl or sulfonic or alkylsulfoxide or alkylsulfonamido or NR13R14, together with the nitrogen to which they are attached a 5-8 link heterocycle not comprising a peroxide nor diazo nor nitroso radical of which one or more carbon atoms of the carbon cycle can be replaced by O or N or S or SO2 or substituted with R4; R4halogen, 1-4C alkyl optionally substituted with one or more hydroxy or carboxy or 1-4C alkoxycarbonyl or 1-4C alkoxy or NR5R6, carboxy, mono- or dialkyl(1-4C)carboxamido, alkyl(1-4C)sulfonyl, alkylsulfonamido, hydroxy, 1-4C alkoxy, 2-4C hydroxyalkoxy, aminosulfonyl, 1-4C thioether, alkyl(1-4C)sulfoxide, alkyl(1-4C)sulfonyl, NR7R8; R3R9SO2NH-, R10C(O)NH- ; R9, R10phenyl or 5-6 link aromatic heterocycle optionally substituted with one or more of halogen or hydroxy or 1-4C alkoxy or carboxy or 1-4C alkoxycarbonyl or mono- or dialkyl(1-4C)carboxamido or alkyl(1-4C)sulfonyl or sulfonic or alkyl(1-4C)sulfoxide or 1-4C thioether or alkylsulfonamido or NR11R12 or 1-4C alkyl optionally substituted with one or more hydroxy or 1-4C alkoxy or carboxy or mono- or dialkyl(1-4C)carboxamido or alkyl(1-4C)sulfonyl or sulfonic or alkyl(1-4C)sulfoxide or alkylsulfonamido or NR13R14, 1-8C alkyl optionally substituted with one or more hydroxy or OR15 or carboxy or 1-4C alkoxycarbonyl or mono- or dialkyl(1-4C)carboxamido or alkyl(1-4C)sulfonyl or alkyl(1- 4C)sulfoxide or alkylsulfonamido or NR16R17; R5-R17H, alkyl(1-4C)sulfonyl, alkyl(1-4C)-CO, mono- or dialkylcarboxamido, 1-4C alkyl optionally substituted with one or more hydroxy or 1-4C alkoxy or alkyl(1-4C)sulfonyl or alkyl(1-4C)sulfonamido or carboxy or mono- or dialkylcarboxamido or alkyl(1-4C)sulfoxide or amino or (di)(1-4C)alkylamino or 2-4C (poly)hydroxyalkylamino; and X : H, halogen, 1-4C alkoxy, phenoxy optionally substituted by one or more halogen or hydroxy or 1-4C alkoxy or carboxy or 1-4C alkoxycarbonyl or mono- or dialkyl(1-4C)carboxamido or alkyl(1-4C)sulfonyl or sulfonic or alkylsulfoxide or 1-4C thioether or alkylsulfonamido or NR13R14, 1-4C alkyl, 1-4C thioether optionally substituted with hydroxy or 1-2C alkoxy or carboxy or sulfonic or amino. R7 and R8 may form, together with the nitrogen to which they are attached a 5-8 link heterocycle optionally substituted with one or more halogen, hydroxy, 1-2C alkoxy, alkylsulfonamido, NR13R14, 1-4C alkyl optionally substituted with one or more hydroxy or 1-4C alkoxy or carboxy or mono- or dialkyl(1-4C)carboxamido or NR13R14. Independent claims are included for: (1) a composition for dyeing keratinic fibers comprising, in a medium appropriate for dyeing, one or more oxidation bases and the claimed thiazole derivative; (2) a method of oxidation dyeing of keratinic fibers comprising application of the claimed composition in the presence of an oxidant agent for sufficient time to achieve the desired color; and (3) a device with several compartments, one containing the claimed composition and another and oxidant composition.