baber/WOPTO huggingface dataset:
Patent WO-2019173763-A1 (WO)
Title: Compositions for use in balancing microbiome
Inventor: GHANNOUM AFIF
IPC: A61K35/745
Filed: 2019-03-08
Abstract: The disclosure generally provides a method of balancing microbiome and/or improving nutrient absorption, treating gut inflammation, and/or balancing the level of Firmicutes and Bacteroidetes in the gut of a subject in need thereof, the method comprising consumption by, or administration to the subject of a composition comprising a nutrient in combination with a probiotic composition comprising (i) an isolated non-pathogenic fungal strain and (ii) an isolated non-pathogenic bacterial strain.
Patent WO-2019183349-A1 (WO)
Title: Modification génétique de génomes mitochondriaux
Inventor: MINCZUK MICHAL
IPC: C12P21/06
Filed: 2019-03-21
Abstract: La présente invention concerne le domaine de l'ingénierie génomique, en particulier la modification génétique ciblée d'ADN mitochondrial (ADNmt).
Patent WO-2019204002-A1 (WO)
Title: Internally cooled tire-wheel system
Inventor: STUCKEY JON I
IPC: B60C23/18
Filed: 2019-03-28
Abstract: A pneumatic tire may include a tread, an inner tire surface positioned opposite the tread, and an internal heat exchanger attached to the inner tire surface. The wheel assembly may include a wheel rim, the pneumatic tire, and a pump. The pneumatic tire may be attached to the wheel rim. The pump may be attached to the wheel rim outside of the pneumatic tire and configured to rotate with the wheel rim. The pump may be coupled to the internal heat exchanger through an opening in the wheel rim. The wheel assembly may further include a coolant disposed in the internal heat exchanger and configured to absorb heat from the pneumatic tire. The wheel assembly may also include an external heat exchanger configured to remove heat from the coolant.
Patent WO-2019195492-A1 (WO)
Title: Methods of producing cells expressing a recombinant receptor and related compositions
Inventor: SATHER BLYTHE D
IPC: C12N15/90
Filed: 2019-04-03
Abstract: Provided are methods for engineering immune cells, cell compositions containing engineered immune cells, kits and articles of manufacture for targeting nucleic acid sequence encoding a recombinant receptor to a particular genomic locus and/or for modulating expression of the gene at the genomic locus, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells. These may involve genetic disruption of at least one site within a TRAC gene and/or a TRBC gene and integration of the transgene encoding for the recombinant receptor at or near one of the at least one target site.
Patent WO-2019204282-A1 (WO)
Title: Methods and apparatus for performing phase operations
Inventor: GIDNEY CRAIG
IPC: G06N10/00
Filed: 2019-04-16
Abstract: Methods, systems, and apparatus for performing phase operations. In one aspect, a method for performing a same phase operation on a first and second qubit using a third qubit prepared in a phased plus state includes: performing a first NOT operation on the third qubit; computing a controlled adder operation on the first, second and third qubit, comprising encoding the result of the controlled adder operation in a fourth qubit; performing a square of the phase operation on the fourth qubit; uncomputing the controlled adder operation on the first, second and third qubit; performing a CNOT operation between the first qubit and the third qubit, wherein the first qubit acts as the control; performing a CNOT operation between the second qubit and the third qubit, wherein the second qubit acts as the control; and performing a second NOT operation on the third qubit.
Patent WO-2019226580-A1 (WO)
Title: Blockchain-anchored smart documents
Inventor: FISHER DAVID
IPC: G06F16/00
Filed: 2019-05-21
Abstract: A smart document includes enhanced metadata and document content. The enhanced metadata may store an embedded database for recording and tracking a document history and rules. The smart document may be hashed to generate a unique document identifier. The unique document identifier is stored in a distributed ledge and paired with exposed metadata for enforcing access rules for the smart document.
Patent WO-2020005437-A1 (WO)
Inventor: CHIN TOM
IPC: H04W48/18
Filed: 2019-05-28
Abstract: La présente invention concerne, selon certains aspects, des techniques servant à sélectionner des politiques pour l'acheminement d'un trafic de données. Certains aspects concernent un procédé de communication sans fil par un équipement d'utilisateur (UE). Le procédé comprend généralement les étapes consistant à sélectionner au moins une politique pour l'acheminement d'un trafic de données vers un réseau, la politique comportant une politique de découverte et de sélection de réseau d'accès (ANDSP) si l'ANDSP est mise en service pour l'UE indépendamment du fait que l'UE soit inscrit auprès d'un réseau central par paquets évolué (EPC) ou d'un réseau central de cinquième génération (5GCN), et à communiquer le trafic de données au réseau selon la sélection.
Patent WO-2019232161-A1 (WO)
Title: Biomarkers and therapeutics for endocrine therapy resistance
Inventor: LISANTI MICHAEL
IPC: C12Q1/68
Filed: 2019-05-30
Abstract: Cancer cells can develop resistance to endocrine therapies, such as Tamoxifen, through acquisition of the Y537S mutation. Cells transfected with the Y537S mutation showed significant increases in mitochondrial mass and membrane potential, consistent with an increase in mitochondrial biogenesis. Certain biomarkers are identified that have prognostic value of endocrine therapy resistance. The mechanism resulting in this resistance, however, leaves these treatment-resistant cells vulnerable to therapeutics that inhibit mitochondrial biogenesis. Numerous mitochondrial biogenesis inhibitors are disclosed, as well as methods for reducing or eliminating endocrine treatment resistance, improving the effectiveness of an endocrine therapy, and for treating cancer.
Patent WO-2019245725-A1 (WO)
Inventor: STAFFORD JEFFREY R
IPC: G02B5/32
Filed: 2019-05-31
Abstract: A volume holographic film (26) (such as a photopolymer) that is pre-recorded with patterns (200, 300, 400, 500) subsequently is used to encode LED or low-power laser light reflections from an eye (901) into a binary pattern that can be read at very high speeds by a relatively simple complementary metal-oxide-semiconductor (CMOS) sensor (904) that may be similar to a high framerate, low resolution mouse sensor. The low-resolution mono images from the film are translated (1108) into eye poses using, for instance, a look up table that correlates binary patterns to X, Y positions or using a pre-trained convolutional neural network to robustly interpret many variations of the binary patterns for conversion to X, Y positions.
Patent WO-2019236590-A1 (WO)
Title: Methods for preventing acute kidney injury
Inventor: BLAUSTEIN MORDECAI
IPC: C07K16/40
Filed: 2019-06-04
Abstract: The present invention provides a method of preventing, reducing or attenuating acute kidney injury in a subject at risk of experiencing a transient increase in kidney ischemia or hypoxia, comprising administering to the subject an effective amount of an agent that binds to and neutralizes endogenous ouabain (EO).
Patent WO-2019245870-A1 (WO)
Title: Éducation assistée par réalité mixte utilisant des modèles virtuels ou des représentations virtuelles pour des procédures orthopédiques chirurgicales
Inventor: KUESTER W MATTHEW
IPC: G09B23/28
Filed: 2019-06-13
Abstract: La présente invention concerne un système indicatif de démonstration d'au moins un aspect d'une procédure orthopédique chirurgicale comprenant un premier dispositif et un second dispositif. Dans cet exemple, le premier dispositif est configuré pour afficher une présentation à un premier utilisateur, la présentation comprenant un ou plusieurs éléments virtuels et lesdits éléments virtuels comprenant une représentation virtuelle tridimensionnelle (3D) d'une ou plusieurs caractéristiques anatomiques associées à la procédure orthopédique chirurgicale. Dans cet exemple, le second dispositif est configuré pour afficher la présentation à un second utilisateur. Dans cet exemple, lesdits éléments virtuels démontrent au moins un aspect de la procédure orthopédique chirurgicale et le contrôle d'au moins une partie desdits éléments virtuels sont attribuables du premier dispositif au second dispositif.
Patent WO-2019245989-A1 (WO)
Inventor: WALKER JAMES
IPC: F21K9/66
Filed: 2019-06-17
Abstract: A apparatus to cover a lighting apparatus is provided. The apparatus includes a flexible material couplable to a lighting apparatus. A portion of the flexible material to cover a light-emitting surface of the lighting apparatus is transparent.
Patent WO-2020006562-A1 (WO)
Title: Integrated security and threat prevention and detection device
Inventor: SEEBER PETER
IPC: G06F21/57
Filed: 2019-07-01
Abstract: An integrated computer network security and threat prevention and detection platform includes a central processor and a display operable to aggregate and present data from a plurality of network security applications in an integrated dashboard format to a system administrator. The network security applications may be hardware, software, or hybrid applications running on local machines, local networks, remote machines, or remote networks, in communication with the central processor. In one embodiment implementation of the integrated computer network security and threat prevention and detection platform is performed on premises, in an alternative embodiment the integrated computer network security and threat prevention and detection platform is provided in an Internet or cloud-based environment, in other embodiments the computer system security platform is a hybrid configuration having both on-premises and cloud base components.
Patent WO-2020014050-A1 (WO)
Title: Engineered pantothenate kinase variant enzymes
Inventor: BORRA-GARSKE MARGIE
IPC: C12N15/52
Filed: 2019-07-02
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
Patent WO-2021015733-A1 (WO)
Inventor: MEHANDJIYSKY DIMITRE D
IPC: H04R1/10
Filed: 2019-07-22
Abstract: A system, method, and apparatus for modifying the state of headphones is disclosed. For example, a system may include a pair of headphones in a first state and a headphone assembly physically connecting the pair of headphones. The system may include a biometric sensor located on the headphone assembly. The system may also include a local authenticator located in the pair of headphones to switch the headphones to a second state in response to a user providing authentication to the pair of headphones by interacting with the biometric sensor.
Patent WO-2020028549-A1 (WO)
Title: Compositions and methods for treating neurodegenerative disorders
Inventor: QI XIN
IPC: A61P25/14
Filed: 2019-07-31
Abstract: A method of inhibiting aberrant ATAD3A activation and/or oligomerization in mitochondria of a cell includes administering to the cell a therapeutic agent that inhibits binding or complexing of ATAD3A with Drp1 in the mitochondria of the cell.
Patent WO-2020041117-A1 (WO)
Title: Robotic manipulation of objects for grip adjustment
Inventor: CHAVAN DAFLE NIKHIL
IPC: B65G61/00
Filed: 2019-08-16
Abstract: Embodiments described herein relate to systems and methods for adjusting a grip on an object held by a gripper of a robotic system. The gripper may manipulate the object to bring a portion of the object into contact with a supporting surface underlying the object, and the gripper may undergo one or more displacements relative the object to apply frictional pushes to the object while the object is held stationary against the supporting surface. The gripper maintains contact with the object during the one or more displacements, and the displacement(s) may be at least partially directed towards the supporting surface. According to some aspects, such manipulation strategies may provide a functionality of fix tuning an object for regripping without requiring customized fixture hardware.
Patent WO-2020041436-A1 (WO)
Title: Lid and knob configured for stacking
Inventor: TRUONG JACQUELYN
IPC: A47J36/06
Filed: 2019-08-21
Abstract: A pot or pan lid is configured for stacking with identical or differently sized lids that have an identical handle or knob with a dimple on the upper surface. The side of the lid opposite the handle has a complimentary protrusion configured to stably engage the dimple. The edge of the knob may extend laterally to correspond with the lid curvature to also support a similar lid on the knob perimeter that is distal from the dimple. The engaged central dimple and more distal perimeter of the knob provide for stable stacking of a plurality of lids in a level arrangement that avoids one or more lids tipping over.
Patent WO-2020041542-A1 (WO)
Title: Liquid solution concentration system comprising isolated subsystem and related methods
Inventor: STOVER RICHARD
IPC: B01D61/02
Filed: 2019-08-22
Abstract: Liquid solution concentration systems, and related methods, are generally described. In some embodiments, the system is an osmotic system comprising a plurality of osmotic modules. For example, the osmotic system can comprise a feed osmotic module configured to produce an osmotic module retentate outlet stream having a higher concentration of solute than the retentate inlet stream transported to the feed osmotic module. The osmotic system can also comprise an isolation osmotic module fluidically connected to the feed osmotic module. The osmotic system can also optionally comprise a purification osmotic module fluidically connected to the feed osmotic module and/or the isolation osmotic module. Certain embodiments are related to altering the degree to which the feed osmotic module retentate outlet stream is recycled back to the retentate- side inlet of the feed osmotic module during operation. Additional embodiments are related to the manner in which the retentate- side effluent from the isolation osmotic module is distributed among the system modules during operation.
Patent WO-2020047360-A1 (WO)
Title: Composés de benzimidazole et leur utilisation pour traiter la maladie d'alzheimer ou la maladie de huntington
Inventor: SHIH CHUAN
IPC: A61K31/4184
Filed: 2019-08-30
Abstract: La présente invention concerne des composés de benzimidazole de formule (I), décrite ci-dessous. Les composés sont des inhibiteurs puissants de la glutaminyl-cyclase humaine. L'invention concerne en outre une composition pharmaceutique contenant l'un de ces composés et un véhicule pharmaceutiquement acceptable, ainsi qu'un procédé de traitement de la maladie d'Alzheimer ou de la maladie de Huntington par administration à un sujet en ayant besoin d'une quantité efficace d'un tel composé.
Patent WO-2020072545-A1 (WO)
Title: MicroRNA TRANSCRIPTIONAL SIGNATURE (miR-TS) EVALUATION OF STEM CELLS
Inventor: GONZALEZ-CADAVID NESTOR F
IPC: C40B30/04
Filed: 2019-10-01
Abstract: Aspects of the present disclosure include methods of evaluating stem cells. Aspects of the methods include obtaining a microRNA transcriptional signature (miR-TS), i.e., a microRNA transcriptional phenotype, for a stem cell and using the obtained miR-TS to evaluate the stem cell. Also provided are kits and compositions for practicing the subject methods. The methods and compositions find use in a variety of different applications, including diagnostic applications, therapeutic applications, research applications, and the like.
Patent WO-2020072605-A1 (WO)
Title: Ionizable amine lipids
Inventor: PARMAR RUBINA
IPC: A61K9/51
Filed: 2019-10-02
Abstract: The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
Patent WO-2020092728-A1 (WO)
Title: Composition of livestock feed and method of manufacturing the same
Inventor: GOMBOS JOHN M
IPC: A23K30/10
Filed: 2019-10-31
Abstract: A feed product for livestock is made up of alfalfa and corn silage, each having a specified moisture content. The alfalfa and corn silage are blended and baled to achieve a moisture content of approximately 30 percent and a dry matter intake of approximately 70 percent without requiring any rehydration.
Patent WO-2020097315-A1 (WO)
Title: Analyse transcriptomique complète de cellules uniques à l'aide d'un amorçage aléatoire
Inventor: SHUM ELEEN
IPC: C12Q1/6806
Filed: 2019-11-07
Abstract: L'invention concerne des systèmes, des procédés, des compositions et des kits permettant une analyse transcriptomique complète (WTA) avec un amorçage et une extension aléatoires (RPE). Le procédé WTA basé sur RPE peut consister à hybrider des amorces aléatoires avec une pluralité de polynucléotides à code-barres de premier brin associés à un support solide et étendre les amorces aléatoires afin de générer une pluralité de produits d'extension. Le procédé peut consister à amplifier la pluralité de produits d'extension afin de générer une bibliothèque de séquençage.
Patent WO-2020106526-A1 (WO)
Title: Low viscosity uv-curable formulation for 3d printing
Inventor: GANAPATHIAPPAN SIVAPACKIA
IPC: C08K5/00
Filed: 2019-11-13
Abstract: A liquid precursor material for dispensing in an additive manufacturing process includes a meth(acrylate) functional oligomer, a reactive diluent, a meth(acrylamide) monomer, and a N-vinyl containing monomer.
Patent WO-2020106816-A1 (WO)
Inventor: Panarese Joseph
IPC: A61K31/473
Filed: 2019-11-20
Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Patent WO-2020106875-A1 (WO)
Title: Self-assembled microcapsules with stimuli-responsive organic ligands
Inventor: BAXTER RYAN
IPC: A61K9/14
Filed: 2019-11-20
Abstract: Self-assembled organic ligand functionalized microcapsules encapsulating one or more substrates, which release the substrates upon activation with a power source, are provided. Compositions that include these microcapsules, as well as methods of making the microcapsules and releasing the encapsulated substrates are also provided. The structures, compositions and methods find use in a variety of applications, such as drug and cell encapsulation technologies, for direct delivery, control, and activation of medicines and therapies to specific tissues in a living host.
Patent WO-2020236220-A1 (WO)
Title: Acoustic sensor systems and methods
Inventor: BREAUX BRIAN DAVID
IPC: E21B17/02
Filed: 2019-12-12
Abstract: Disclosed is an acoustic sensor system comprising an electrical connector, at least one transducer connected to the electrical connector, a fluid compensating piston connected to the electrical connector, a housing having the electrical connector, the at least one transducer, and the fluid compensating piston arranged in a linear arrangement, and a collar having the housing mounted along an interior surface of the collar.
Patent WO-2020132055-A1 (WO)
Inventor: O'BRIEN TIMOTHY D
IPC: C12N5/077
Filed: 2019-12-18
Abstract: Procédés de production d'organoïdes comprenant, par exemple, la production d'un organoïde à tissus multiples. L'organoïde à tissus multiples peut impliquer un cartilage, un os, un épithélium et/ou un tissu conjonctif fibreux. La présente invention concerne en outre des procédés d'isolement de cellules à partir des organoïdes et des procédés d'utilisation des organoïdes et des cellules des organoïdes.
Patent WO-2020146721-A1 (WO)
Inventor: BLUMENSTEIN DAMON
IPC: H01M50/296
Filed: 2020-01-10
Abstract: An accessory power center for a vehicle includes: a first terminal configured to be connected to a first reference potential of a battery of the vehicle; a second terminal configured to be connected to a second reference potential of the battery; and a fuse holder that includes: a first end that is electrically connected to the first terminal; and a second end. A first connector is configured to connect to a second connector of an accessory, the first connector including: a first electrical conductor that is electrically connected to the second end of the fuse holder; a second electrical conductor that is electrically connected to the second terminal; a third electrical conductor that is configured to receive power when backlights of the vehicle are powered; and a fourth electrical conductor that is configured to receive power when an ignition system of the vehicle is in an accessory state.
Patent WO-2020150366-A1 (WO)
Title: Acides carboxyliques polycycliques substitués, analogues de ceux-ci, et procédés faisant appel à ceux-ci
Inventor: CHEN SHUAI
IPC: A61K31/4375
Filed: 2020-01-15
Abstract: La présente invention concerne des acides carboxyliques polycycliques substitués, des analogues de ceux-ci, et des compositions les comprenant, lesquels peuvent être utilisés pour traiter et/ou prévenir une infection par le virus de l'hépatite B (HBV) et/ou le virus de l'hépatite D (VHD) chez un patient. Dans certains modes de réalisation, l'invention concerne un composé de formule (I), ou un sel, un solvate, un isomère géométrique, un stéréoisomère, un tautomère et des mélanges quelconques de ceux-ci.
Patent WO-2020154314-A1 (WO)
Title: Cathéters à hypotube
Inventor: FOJTIK SHAWN P
IPC: A61M29/00
Filed: 2020-01-21
Abstract: La présente invention concerne un cathéter comprenant un hypotube et un revêtement. L'hypotube peut s'étendre sensiblement le long d'une longueur du cathéter. Le revêtement peut s'étendre le long d'une majorité de la longueur de l'hypotube, et peut s'étendre sensiblement le long de la totalité de la longueur de l'hypotube. L'hypotube comprend des caractéristiques d'amélioration de la flexibilité le long de sa longueur. De plus, l'hypotube peut comprendre une ou plusieurs caractéristiques fonctionnelles, qui peuvent permettre d'effectuer diverses procédures grâce au cathéter. Le revêtement peut être positionné adjacent à une surface intérieure d'une paroi de l'hypotube, ou il peut être positionné adjacent à une surface extérieure de la paroi de l'hypotube. Toutes les caractéristiques fonctionnelles de l'hypotube peuvent être exposées à travers ou au-delà d'une étendue longitudinale du revêtement ou d'une partie de ce dernier. L'invention concerne également des procédés de fabrication de cathéters qui comprennent des hypotubes et des revêtements.