Patent GB-0520436-D0 (GB)
Title: Biological materials and uses thereof
IPC: A61K49/00
Filed: 2005-10-07
Abstract: <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="offset" colwidth="84pt" align="left"/> <colspec colname="1" colwidth="133pt" align="center"/> <colspec colname="2" colwidth="0pt" align="left"/> <thead> <row> <entry/> <entry namest="offset" nameend="2" align="center" rowsep="1"/> </row> </thead> <tbody valign="top"> <row> <entry/> <entry>FR1</entry> <entry/> </row> </tbody> </tgroup> <tgroup align="left" colsep="0" rowsep="0" cols="5"> <colspec colname="offset" colwidth="21pt" align="left"/> <colspec colname="1" colwidth="35pt" align="left"/> <colspec colname="2" colwidth="28pt" align="left"/> <colspec colname="3" colwidth="133pt" align="left"/> <colspec colname="4" colwidth="0pt" align="left"/> <tbody valign="top"> <row> <entry/> <entry/> <entry/> <entry> 1 2 3</entry> <entry/> </row> <row> <entry/> <entry>H1-H2</entry> <entry>Locus</entry> <entry>123456789012345678901234567890</entry> </row> <row> <entry/> <entry namest="offset" nameend="4" align="center" rowsep="1"/> </row> </tbody> </tgroup> <tgroup align="left" colsep="0" rowsep="0" cols="5"> <colspec colname="1" colwidth="21pt" align="left"/> <colspec colname="2" colwidth="35pt" align="left"/> <colspec colname="3" colwidth="28pt" align="left"/> <colspec colname="4" colwidth="133pt" align="left"/> <colspec colname="5" colwidth="0pt" align="left"/> <tbody valign="top"> <row> <entry>VH1</entry> <entry>1-3</entry> <entry>1-02</entry> <entry>QVQLVQSGAEVKK<u style="single">PGASVKVSCKASGYTFT</entry> <entry/> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-03</entry> <entry>QVQLVQSGAEVKKPGASVKVSCKASGYTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-08</entry> <entry>QVQLVQSGAEVKKPGASVKVSCKASGYTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-18</entry> <entry>QVQLVQSGAEVKKPGASVKVSCKASGYTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-U</entry> <entry>1-24</entry> <entry>QVQLVQSGAEVKKPGASVKVSCKVSGYTLT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-45</entry> <entry>QMQLVQSGAEVKKTGSSVKVSCKASGYTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-46</entry> <entry>QVQLVQSGAEVKKPGASVKVSCKASGYTF<u style="single">T</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-58</entry> <entry>QMQLVQSGPEVKKPGTSVKVSCKASGFTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-69</entry> <entry>QVQLVQSGAEVKKPGSSVKVSCKASGGTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-e</entry> <entry>QVQLVQSGAEVKKPGSSVKVSCKASGGTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-f</entry> <entry>EVQLVQSGAEVKKPGATVKISCKVSGYTFT</entry> </row> <row> <entry> </entry> </row> <row> <entry>VH2</entry> <entry>3-1/2-1</entry> <entry>2-05</entry> <entry>QITLKESGPTLVKPTQTLTLTCTFSGFSLS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>3-1</entry> <entry>2-26</entry> <entry>QVTLKESGPVLVKPTETLTLTCTVSGFSLS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>3-1</entry> <entry>2-70</entry> <entry>QVTL<u style="single">KESGPALVKPTQTLTLTCTFSCFSLS</entry> </row> <row> <entry> </entry> </row> <row> <entry>VH3</entry> <entry>1-3</entry> <entry>3-07</entry> <entry>EVQLVESGGGLVQPGGSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-09</entry> <entry>EVQLVESGGGLVQPGRSLRLSCAASGFTFD</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-11</entry> <entry>QVQLVESGGGLVKPGGSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-1</entry> <entry>3-13</entry> <entry>EVQLVESGGSLVQPGG<u style="single">SLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-U</entry> <entry>3-15</entry> <entry>EVQLVESGG<u style="single">GLVKPGGSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-20</entry> <entry>EVQLVFSGGSVVRPGGSLRLSCAASGFTFD</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-21</entry> <entry>EVQLVESGGGLVKPGGSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-23</entry> <entry>EVQLLESGGGLVQPGGSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30</entry> <entry>QVQLVESSGGVVQPG<u style="single">RSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30.3</entry> <entry>QVQLVESGGGVVQPGRSLRLSCAASGFTFS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30.5</entry> <entry>QVQLVESGGGVVQPGRSLRLSCAASGFTFS</entry> </row> <row> <entry namest="1" nameend="5" align="center" rowsep="1"/> </row> <row> <entry> </entry> </row> </tbody> </tgroup> <tgroup align="left" colsep="0" rowsep="0" cols="6"> <colspec colname="offset" colwidth="21pt" align="left"/> <colspec colname="1" colwidth="35pt" align="left"/> <colspec colname="2" colwidth="42pt" align="left"/> <colspec colname="3" colwidth="42pt" align="left"/> <colspec colname="4" colwidth="77pt" align="left"/> <colspec colname="5" colwidth="0pt" align="left"/> <tbody valign="top"> <row> <entry/> <entry/> <entry/> <entry/> <entry>FR2</entry> <entry/> </row> <row> <entry/> <entry/> <entry/> <entry>CDR1</entry> <entry> 4</entry> </row> <row> <entry/> <entry>H1-H2</entry> <entry>Locus</entry> <entry>1ab2345</entry> <entry>67890123456789</entry> </row> <row> <entry/> <entry namest="offset" nameend="5" align="center" rowsep="1"/> </row> </tbody> </tgroup> <tgroup align="left" colsep="0" rowsep="0" cols="6"> <colspec colname="1" colwidth="21pt" align="left"/> <colspec colname="2" colwidth="35pt" align="left"/> <colspec colname="3" colwidth="42pt" align="left"/> <colspec colname="4" colwidth="42pt" align="left"/> <colspec colname="5" colwidth="77pt" align="left"/> <colspec colname="6" colwidth="0pt" align="left"/> <tbody valign="top"> <row> <entry>VH1</entry> <entry>1-3</entry> <entry>1-02</entry> <entry>G--YYMH</entry> <entry>WVRQAPGQGLEWMG</entry> <entry/> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-03</entry> <entry>S--YAMH</entry> <entry>WVRQAPGQRLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-08</entry> <entry>S--YDIN</entry> <entry>WVRQATGQGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-18</entry> <entry>S--YGIS</entry> <entry>WVRQAPGQGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-U</entry> <entry>1-24</entry> <entry>E--LSMH</entry> <entry>WVRQAPGKGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-45</entry> <entry>Y--RYLH</entry> <entry>WVRQAP<u style="single">GQALEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-46</entry> <entry>S--YYMH</entry> <entry>WVRQAPGQGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>1-58</entry> <entry>S--SAVQ</entry> <entry>WVRQARGQRLEWIG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-69</entry> <entry>S--Y<u style="single">AIS</entry> <entry>WVRQAPGQGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-e</entry> <entry>S--YAIS</entry> <entry>WVRQAPGQGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-2</entry> <entry>1-f</entry> <entry>D--YYMH</entry> <entry>WVQQAPGKGLEWMG</entry> </row> <row> <entry> </entry> </row> <row> <entry>VH2</entry> <entry>3-1/2-1</entry> <entry>2-05</entry> <entry>TS<u style="single">GVGVG</entry> <entry>WIRQPPGKALEWLA</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>3-1</entry> <entry>2-26</entry> <entry>NARMGVS</entry> <entry>WIRQPPGKALEWLA</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>3-1</entry> <entry>2-70</entry> <entry>TSGM<u style="single">RVS</entry> <entry>WIRQPPGKALEWLA</entry> </row> <row> <entry> </entry> </row> <row> <entry>VH3</entry> <entry>1-3</entry> <entry>3-07</entry> <entry>S--YWMS</entry> <entry>WVRQAPGKGLEWVA</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-09</entry> <entry>D--YAMH</entry> <entry>WVRQAPGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-11</entry> <entry>D--YYMS</entry> <entry>WIRQAPGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-1</entry> <entry>3-13</entry> <entry><u style="single">S--YDMH</entry> <entry>WVRQATGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-U</entry> <entry>3-15</entry> <entry>N--AWMS</entry> <entry>WVRQAPGKGLEWVG</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-20</entry> <entry>D--YGMS</entry> <entry>WVRQAPGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-21</entry> <entry>S--YSMN</entry> <entry>WVRQAPGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-23</entry> <entry>S--YAMS</entry> <entry>WVRQAPGKGLEWVS</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30</entry> <entry>S--Y<u style="single">GMH</entry> <entry>WVRQAPGKGLEWVA</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30.3</entry> <entry>S--YAMH</entry> <entry>WVRQAPGKGLEWVA</entry> </row> <row> <entry> </entry> </row> <row> <entry/> <entry>1-3</entry> <entry>3-30.5</entry> <entry>S--YGMH</entry> <entry>WVRQAPGKGLEWVA</e