Patent SG-11201803679T-A (SG)
Title: Antibodies and antibody fragments for site-specific conjugation
Inventor: MA DANGSHE
IPC: C07K16/32
Filed: 2016-11-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 8 June 2017(08.06.2017) WIPOIPCT (10) International Publication Number WO 2017/093845 Al (51) International Patent Classification: C07K16/32 (2006.01) A61K 47/68 (2017.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/IB2016/057018 (22) International Filing Date: (25) Filing Language: (26) Publication Language 22 November 2016 (22.11.2016) English (30) Priority Data: 62/260,854 30 November 2015 (30.11.2015) 62/289,744 1 February 2016 (01.02.2016) 62/409,323 17 October 2016 (17.10.2016) US US us (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, New York 10017 (US). (72) Inventors: MA, Dangshe; 49 Glenwood Road, Millwood, New York 10546 (US). MARQUETTE, Kimberly Ann; 66 Springfield Street, Apt. #1, Somerville, Massachusetts 02143 (US). GRAZIANI, Edmund Idris; 497 South Pas- cack Road, Chestnut Ridge, New York 10977 (US). SAPRA, Puj a; 254 Wayne Avenue, River Edge, New Jer­ sey 07661 (US). TUMEY, Lawrence Nathan; 37 William Street, Pawcatuck, Connecticut 06379 (US). PRASHAD, Nadira Anarkali; 18 Parliament Drive, New City, New York 10956 (US). KHANDKE, Kiran Manohar; 120 East Allison Avenue, Nanuet, New York 10954 (US). BENNETT, Eric M.; 45 Morningside Drive, Arlington, Massachusetts 02474 (US). TCHISTIAKOVA, Lioudm- ila; 3 O'Grady Circle, Stoneham, Massachusetts 02180 (US). (74) Agents: WALDRON, Roy F. et al.; PFIZER INC., 235 East 42nd Street, MS 235/9/S20, New York, New York 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (§4) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) < if) Tf 00 ON n O (54) Title: ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION (57) : The inventionrelates to polypeptides, antibodies,and antigen-binding fragments thereof, that comprise a substituted- cysteine for site-specific conjugation.