Patent SG-11201810516U-A (SG)
Title: Combinations comprising histone deacetylase inhibitors
Inventor: SHUTTLEWORTH STEPHEN JOSEPH
IPC: A61K31/501
Filed: 2017-06-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/208032 Al 07 December 2017 (07.12.2017) W I PO I PCT (51) International Patent Classification: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 31/433 (2006.01) A61K 31/506 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 31/4427 (2006.01) A61P 35/00 (2006.01) A61K 31/4439 (2006.01) A61K 31/69 (2006.01) (84) Designated States (unless otherwise indicated, for every A61K 31/497 (2006.01) A61K 38/07 (2006.01) kind of regional protection available): ARIPO (BW, GH, A61K 31/501 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (21) International Application Number: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PCT/GB2017/051619 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (22) International Filing Date: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 05 June 2017 (05.06.2017) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: English (26) Publication Language: English Published: — with international search report (Art. 21(3)) (30) Priority Data: — before the expiration of the time limit for amending the 1609786.7 03 June 2016 (03.06.2016) GB claims and to be republished in the event of receipt of (71) Applicant: KARUS THERAPEUTICS LTD [GB/GB]; amendments (Rule 48.2(h)) Genesis Building, Library Avenue, Harwell Campus Ox- fordshire OX11 OSG (GB). (72) Inventors: SHUTTLEWORTH, Stephen Joseph; Gen- esis Building, Library Avenue, Harwell Campus, Oxford- shire OX11 OSG (GB). WHALE, Andrew David; Genesis Building, Library Avenue, Harwell Campus, Oxfordshire OX11 OSG (GB). COLMAN, Lucy Mary; Genesis Build- = ing, Library Avenue, Harwell Campus, Oxfordshire OX11 OSG (GB). ROGERS, Helen Louise; Genesis Building, Li- brary Avenue, Harwell Campus, Oxfordshire OX11 OSG (GB). (74) Agent: STEVENS, Fiona; Gill Jennings & Every LLP, The Broadgate Tower, 20 Primrose Street, London Greater Lon- don EC2A 2ES (GB). Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (54) Title: COMBINATIONS COMPRISING HISTONE DEACETYLASE INHIBITORS 1-1 R2 (57) : The invention relates to a combination of a compound of formu- la (I) or a pharmaceutically acceptable salt thereof, and at least one second agent ei en R2 selected from the group consisting of proteasome inhibitors, tumour immunother- 0 L VV apeutics or immunomodulatory agents, signal transduction pathway inhibitors, GC = ei IN R' 1 N 1. D 3 agents inhibiting the BCL2 family of proteins, agents inhibiting Mcl-1, poly (ADP- I ribose) polymerase (PARP) Inhibitors, aromatase inhibitors, conventional cyto- toxic agents or a miscellaneous agent selected from abiraterone, ARN-509 and 1-1 L R' MYC inhibitors. 0 ei R' (I) 0