baber/WOPTO huggingface dataset:
Patent NZ-511568-A (NZ)
Title: An inhalation system using lipids for the delivery of bioactive compounds
Inventor: PILKIEWICZ FRANK G
IPC: A61K33/242
Filed: 1999-11-12
Abstract: A system for administering a bioactive compound by inhalation comprising: (a) a composition comprising the biologically-active compound and a lipid mixture; and (b) an inhalation delivery device; wherein the lipid mixture comprises: (1) a first mixture comprising phosphatidylcholine, negativelycharged lipid, and sterol in the molar ratio of 1-20: 1-10: 0.5-5; (2) a second mixture comprising phosphatidylcholine, negatively-charged lipid and albumin in the molar ratio of 1-20: 1-10: 0.1-10; (3) a third mixture comprising phosphatidylcholine, positively-charged lipid and phosphatidylethanolamine in the molar ratio of 1-20: 0.520:1-10; (4) a fourth lipid mixture having phosphatidylcholines: negatively-charged lipids: phosphatidylethanolamines in the molar ratio of 1-20: 1-10: 110; (5) a fifth lipid mixture having phosphatidylcholines: positively-charged lipids: albumin compounds in the molar ratio of 1-20: 0.5-20: 0.1-10; or (6) a sixth lipid mixture having phosphatidylcholines: positively-charged lipids: sterol compounds in the molar ratio of 1-20: 0.5-20: 0.5-5. wherein the bioactive agent lipid mixture weight ratio is from 10: 1 to 1: 500.
Patent NZ-519961-A (NZ)
Title: Multi-layer heat-sealable packaging material, a food package made thereof and a method of packaging
Inventor: PENTTINEN TAPANI
IPC: B65D81/30
Filed: 2001-04-09
Abstract: The disclosure relates to multi-layer heat-sealable packaging material especially for food packages. In addition, objects of the invention are a food package formed of the said packaging material, a method of packaging, and the use of the material for packages. The packaging material (1) comprises a middle layer (3) of fibre material, such as cardboard; at least one polymeric protective layer (4, 5) protecting the product from going bad; and polymeric heat sealing layers (2, 7) preferably on both sides of the packaging material. According to the invention, the heat sealing layer (7) forming the inner surface of the closed package, is blended with light-absorbing pigment, such as carbon black, for protecting the product from visible light. By further blending white pigment, such as titanium dioxide, into the heat sealing layer (7), a grey tint resembling an aluminium foil has been achieved for the layer. The heat sealing polymer may be low-density polyethylene (PE-LD), and an oxygen and aroma proof sealing layer (4) of, for example, ethylene vinyl alcohol copolymer (EVOH) or polyamide (PA) may be provided between it and the cardboard (3).
Patent NZ-520840-A (NZ)
Title: Bone fixation assembly
Inventor: BRACE MICHAEL
IPC: A61B17/70
Filed: 2001-03-28
Abstract: A bone fixation assembly for securing a fixation device, such as a bone plate, to bone. The assembly includes the fixation device, a bushing, a fastening screw, and a locking screw. The bushing is seated within a through hole in the fixation device and can rotate within the through hole and has a sidewall with a bore. The sidewall has at least one slot for allowing outward expansion of the sidewall against the through hole to thereby lock the bushing at a selected angle relative to the axis of the through hole. The fastening screw has a threaded shaft for insertion through the bore of the bushing and threads into bone to secure the bushing and fixation device to bone. The head of the fastening screw fits in the bushing and includes a radial wall and open end defining a recess. The radial sidewall has at least one slit for allowing outward expansion of the radial wall thereby outwardly expanding the sidewall of the bushing. The locking screw has a body that thread in the head of the fastening screw to thereby outwardly expand the radial wall of the fastening screw
Patent NZ-522358-A (NZ)
Title: Carpet weaving
Inventor: BURTON MICHAEL WINSPEAR
IPC: D05C15/20
Filed: 2001-05-11
Abstract: A carpet weaving loom including at least one tuft forming unit (1) for forming sequentially yarn tufts (7) of a number of different colours, means to receive and hold at yarn tuft holding sites (8) yarn tufts supplied sequentially by the tuft forming unit (1), and transfer means (10) to transfer all of the tufts (7) held by the yarn tuft holding sites (8) simultaneously to their corresponding weaving points. The or each tuft forming unit supplies yarn tufts (7) to at least twenty yarn tuft holding sites (8) between successive operations of the transfer means (10). When only a single tuft forming unit (1) is provided it preferably supplies tufts to at least one hundred and sixty tuft holding sites (8). When a plurality of tuft forming units (1) are provided each preferably supplies tufts to between twenty and one hundred and twenty tuft holding sites (8). This configuration leads to a considerable reduction in the size of creel with consequent reduction in waste and time taken to thread-up such a loom.
Patent NZ-523182-A (NZ)
Title: Wave energy converter
Inventor: DICK WILLIAM
IPC: F03B13/20
Filed: 2001-06-14
Abstract: A wave energy conversion apparatus is described. It comprises at least two devices (3, 4), each comprising a surface float (5, 6), at least one of the surface floats being rigidly attached to a submerged body (9, 10). The movement of the two devices in response to a passing wave may be used to effect an energy transfer.
Patent NZ-527971-A (NZ)
Title: Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
Inventor: MADISON EDWIN L
IPC: A61K48/00
Filed: 2002-03-27
Abstract: A purified or two chain polypeptide or a catalytically active portion thereof comprises a polypeptide that has the amino acid sequence set forth in SEQ ID NO:18, SEQ ID NO:16, or amino acids 11-242 of SEQ ID NO:6, has serine protease activity and are members of the type II transmembrane serine protease 9 (MTSP9) polypeptide family. Also described are nucleic acids, host cells, vectors and methods of identifying compounds that modulate the protease activity of the polypeptide.
Patent NZ-529565-A (NZ)
Title: Method for the enzymatic production of a curing agent in its fluid state
Inventor: CASEZ HERVE
IPC: C12N11/00
Filed: 2002-05-31
Abstract: The invention relates to a method for the enzymatic production of a curing agent in its fluid state, e.g. liquid, comprising, in free phase, at least one oxygenated chemical species. Said method consists in bringing into contact at least one enzymatic catalysts agent, comprising at lease one peroxidase-type enzyme; an oxidizable substrate in aqueous phase that can be oxidized by the action of an oxygen donor, by catalysis by said enzymatic catalysis agent, generating said oxygenated chemical species in free phase; and said oxygen donor. The inventive method is characterized in that: e) an aqueous reaction bath is formed comprising, in addition to the oxidizable substrate and the oxygen donor, said enzymatic catalysis agent in divided solid phase, but in free phase, distributed is said bath, which may be set in motion; f) the aqueous reaction bath is separated into a fraction enriched with the enzymatic catalysis agent in divided solid phase and a fraction free from said catalysis agent, from which the curing agent is obtained.
Patent NZ-530665-A (NZ)
Title: Apparatus and method for analysing a biological sample in response to microwave radiation
Inventor: ELLISON BRIAN NORMAN
IPC: C12M1/42
Filed: 2002-07-19
Abstract: An apparatus for producing a continuous culture sample is disclosed which includes: a container (602) for growing a luminescent culture; a supply device (604) for supplying culture medium to the container (602), and a transfer device (614) for transferring the culture from the container (602). The apparatus is configured to produce a continuous luminescent culture sample, and further includes: a device for producing a luminescence signal representing a measurement of the luminescence of the culture in the container (602), and a device for producing a turbidity signal representing a measurement of the turbidity of the culture in the container (602). The supply device (604) supplies the culture medium to the container (602) at a first flow rate and the transfer device (614) transfers the culture from the container (602) at a second flow rate. The apparatus further includes a controller (621) for controlling the first flow rate in accordance with the luminescence and turbidity signals.
Patent NZ-533327-A (NZ)
Title: Processes for the measurement of the potency of glatiramer acetate
Inventor: KLINGER ETY
IPC: C12N5/00
Filed: 2002-12-04
Abstract: Disclosed herein is a process for measuring the potency of a test batch of glatiramer acetate relative to the known potency of a reference batch that comprises: (a) Immunizing female (SJLXBALB/C) F1 mice between 8 and 12 weeks of age with a predetermined amount of glatiramer acetate from the reference batch. (b) Preparing a primary culture of lymph node cells from the mice of step (a) 9-11 days after immunization; (c) Separately incubating at least five reference samples, each of which contains predetermined number of cells from the primary culture of step (b) and a predetermined amount of glatiramer acetate between 1 Mg/ml and 25 Mg/ml from a reference batch; (d) Incubating at least two samples, each of which contains a predetermined number of cells from the primary culture of step (b) and a predetermined amount of glatiramer acetate from the test batch; (e) Determining for each sample in steps (c) and (d), the amount interleukin-2 secreted by the cells in each sample after 18-21 hours of incubation of such sample; (f) Correlating the amount of interleukin-2 secreted by the samples incubated with the test batch of glatiramer acetate with the amounts of inteleukin-2 secreted by the samples incubated with the reference batch of glatiramer acetate so as to determine the potency of the test batch of glatiramer acetate relative to the reference batch of glatiramer acetate.
Patent NZ-533649-A (NZ)
Title: Tyrosyl derivatives and their use as P2X7 receptor modulators
Inventor: BARALDI PIER GIOVANNI
IPC: A61P37/00
Filed: 2002-12-23
Abstract: Tyrosyl derivatives and their pharmaceutically acceptable salts of the following general formula are disclosed. Compositions thereof and methods of preparing the compounds are also described. The compounds are useful in the treatment of diseases in mammals that are mediated by the action of the P2X7 receptor.
Patent NZ-534504-A (NZ)
Title: A label-free high throughput optical technique for detecting biomolecular interactions
Inventor: CUNNINGHAM BRIAN T
IPC: G01N21/47
Filed: 2003-01-16
Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high throughput manner. The invention also provides optical devices useful as narrow band filters.
Patent NZ-535941-A (NZ)
Title: Composition for caries prevention
Inventor: YAMANAKA KATSUYUKI
IPC: A61K6/00
Filed: 2004-10-14
Abstract: Disclosed is an oral cavity composition for preventing caries, which is used by applying on a tooth, comprising: (a) 1 o 30% by of the casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) and/or the calcium phosphopeptide-amorphous calcium fluoride phosphate complex (CPP-ACFP), (b) 0.01 to 10% of sodium carboxymethylcellulose having the etherification degree of 0.7 to 1.0, (c) 0.5 to 40% of a viscosity regulator, and (d) a residual amount of water.
Patent NZ-536778-A (NZ)
Title: Novel physiologically active substances
Inventor: KOTAKE YOSHIHIKO
IPC: A61K31/496
Filed: 2003-05-29
Abstract: Disclosed are compounds of formula I, pharmaceutically acceptable salts thereof or hydrates of the same wherein its substituents are as described in the specification. Because of inhibiting angiogenesis (in particular, VEGF production in hypoxia), the compounds are useful as remedies for solid cancer.
Patent NZ-541064-A (NZ)
Title: Benzofuran derivative
Inventor: SATO SEIICHI
IPC: A61P19/02
Filed: 2004-03-03
Abstract: Disclosed is a compound represented by the general formula (1): (wherein R1 represents optionally substituted alkyl or optionally substituted alkenyl; and R2 and R3 each represents hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl, or alkynyl, provided that R2 and R3 may form an optionally substituted, nitrogenous, saturated, heterocyclic group in cooperation with the adjacent nitrogen) and a medicinal composition containing the compound. The compound functions to inhibit the production of a tumour necrosis factor (TNF-alpha) and has satisfactory oral absorbability.
Patent NZ-544146-A (NZ)
Title: Targeted biocides
Inventor: IMBODEN MICHAEL
IPC: A01N63/50
Filed: 2004-05-14
Abstract: Disclosed is a composition comprising a recombinant fusion protein, wherein said protein comprises a microorganism targeting molecule joined to at least a portion of a protein biocide molecule, wherein said microorganism targeting molecule binds to bacteria, and wherein said microorganism targeting molecule is an innate immune system receptor, and wherein said fusion protein neutralizes said bacteria. Also disclosed is methods of use thereof.
Patent NZ-546292-A (NZ)
Title: Hierarchical, multilevel, expand and collapse navigation aid for hierarchical structures including menu items for computers
Inventor: GARDNER DOUGLAS
IPC: G06F3/033
Filed: 2004-09-14
Abstract: A software utility navigation aid for hierarchical structures such as file managers, taxonomies, or tables of contents that displays a dynamic menu when the mouse cursor is hovered over an activator used to swap the expanded/collapsed state of a node displayed in a hierarchical structure is described. The navigational aid comprises, node display means to display the nodes in multilevel hierarchical structure, icon display means for displaying in the vicinity of each node a expand an collapse icon, and menu display means for displaying a dynamic menu associated with a node in the hierarchical structure. The dynamic menu includes options to collapse the node's ancestors, or to display the node or nodes at a level below the selected node. Each displayed entry in this menu, positioned both below and above the identified node, can be clicked to cause the hierarchical structure to expand or collapse to that display level.
Patent NZ-550418-A (NZ)
Title: Liquid concentrated formula
Inventor: MOLENAAR MARIKE JOANNE BERNADETTE
IPC: A23L33/00
Filed: 2005-04-08
Abstract: A liquid complete nutritional composition suitable for feeding cachectic patients, having an energy density of at least 1.45 kcal/ml comprising: a carbohydrate fraction in an amount of 17-27 g per 100 ml; an intact protein fraction in an amount of 8.2-11 g per 100 ml; and a lipid fraction; wherein at least 70 wt.% of the intact protein fraction is obtained by demineralising milk, and the protein fraction comprises between 25 and 37 wt.% of whey proteins. Further provided is a process for producing the liquid composition and a packaged food product comprising the composition.
Patent NZ-564130-A (NZ)
Title: N-propargyl-1-aminoindan compounds useful for treating obesity
Inventor: MCELROY JOHN F
IPC: A61P3/04
Filed: 2006-06-01
Abstract: Disclosed are compounds of formulae I and II, wherein at least one of X, X1, X2 and X3 is a substituent as defined in the specification other than H, alkyl, alkoxy, hydroxyl, CF3 and halo, and the remaining substituents are as defined in the specification. The compounds are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).
Patent NZ-566494-A (NZ)
Title: Adhesive preparation containing bisoprolol
Inventor: IWAO YOSHIHIRO
IPC: A61K9/70
Filed: 2006-09-07
Abstract: Disclosed is an adhesive pharmaceutical preparation containing bisoprolol, which comprises a support and an adhesive layer on one side of the support, wherein the adhesive layer contains bisoprolol, polyisobutylene, a tackifier, and an organic liquid ingredient compatible with polyisobutylene and the tackifier selected from a fatty acid alkyl ester, a long-chain alcohol selected from saturated or unsaturated alcohols having from 12 to 28 carbon atoms, or a combination thereof; and wherein the content of bisoprolol per the total weight of the adhesive layer is 0.5 to 5% by weight.
Patent NZ-566770-A (NZ)
Title: Injection manifold for machine for injecting liquids
Inventor: WATTS EDWARD D
IPC: A23L13/00
Filed: 2004-02-06
Abstract: A machine for needleless injection of liquids into meat includes an injection component which receives high pressure injection fluid and includes a tubular manifold 204 with first 208 and second 210 open ends and a plurality of injection nozzles 196. An end cap 198 includes a fluid entry port 222 and a coaxial screw thread that is screwed onto the first end of the manifold. A flexible sealing ring 230 seals the end cap to the first end. A second end cap 200 is similarly screwed onto the other end of the manifold and sealed to the manifold by a flexible sealing ring 234. The fluid is pumped into the manifold via the fluid entry port to be injected out of the nozzles. The respective end caps allow the manifold to be easily "opened" for cleaning, and the sealing rings prevent the fluid from coming into contact with the threads whereby corrosion of the threads by the fluid is ameliorated.
Patent NZ-579067-A (NZ)
Title: Nitric oxide releasing steroids
Inventor: BENEDINI FRANCESCA
IPC: C07J41/00
Filed: 2008-01-28
Abstract: Disclosed are compounds of general formula R-(Z)a-Rx, wherein R is a steroid of formula (II). Also disclosed is the use of the above mentioned compounds for treating ocular hypertension, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy and retinal vasculopathies.
Patent NZ-579415-A (NZ)
Title: Method of preparing more digestible animal feed
Inventor: ABBAS CHARLES
IPC: A23K10/38
Filed: 2008-03-05
Abstract: Disclosed is a process for making an animal feed comprising: contacting an edible fiber source in a mixture with an inorganic fiber hydrolyzing agent in a continuous process in a mixing device having at least one rotating member that shears the edible fiber and wherein the pressure is about 14 psig to about 50 psig the temperature is about 100°C to 110 °C, and the time is between about 1 second to less than 5 minutes to solubilize a first portion of carbohydrates from lignocellulosic material in the edible fiber source; contacting the edible fiber source with an enzyme fiber degrading agent selected from the group consisting of cellulases, hemicellulases, esterases, phytases, laccases, peroxidases and proteases for a time sufficient to solubilize a second portion of carbohydrates from lignocellulosic material in the edible fiber source; and drying the contacted edible fiber source to form a dried mixture having an insoluble fiber fraction and a soluble carbohydrate fraction derived from a common edible fiber source and wherein the soluble carbohydrate fraction is at least 45% wt/wt of the total carbohydrates contributed by the insoluble fiber fraction and soluble carbohydrate fraction.
Patent NZ-579468-A (NZ)
Title: Method for identifying surface characteristics of metallurgical products using two or more radiation sources and an imaging device
Inventor: RAUBER TOBIAS
IPC: G01N21/88
Filed: 2008-03-19
Abstract: A method for recognising surface characteristics of metallurgical products, especially continuously cast products and rolled products. A defined section of the product surface (12') is irradiated by at least two radiation sources of different wavelengths, from different directions, and the irradiated surface section is optoelectronically detected. Three light sources (21, 22, 23) are oriented towards the product surface, as radiation sources, under the same angle (á), the positions thereof being in three planes (E1, E2, E3) forming a 120° angle and being perpendicular to the product surface. In this way, instructive information about metallurgical products can be determined and stored in a very short space of time such that the products can be determined in a perfectly identified manner for the reprocessing, in terms of the surface quality or surface structure thereof.
Patent NZ-579595-A (NZ)
Title: Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists
Inventor: AHMED MAHMOOD
IPC: A61K31/4245
Filed: 2008-04-17
Abstract: Disclosed are indazole compounds of Formula (I), salts thereof, and methods of their preparation. The indazole core is substituted with an oxadiazole moiety at either R5 or R6, and a carboxylic acid moiety at either R3 or R4. Specific examples of compounds of Formula (I) include: 4-[5-(5-{ 3-Cyano-4-[(1-methylethyl)oxy]phenyl} -1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]butanoic acid, 3-(5-{ 5-[3-Cyano-4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl} -1H-indazol-1-yl)propanoic acid, 3-[4-(5-{ 3-Cyano-4-[(1-methylethyl)oxy]phenyl} -1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]propanoic acid, and 4-[5-(5-{ 3-Chloro-4-[(1-methylethyl)oxy]phenyl} -1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]butanoic acid. The compounds of Formula (I) are useful for the treatment of conditions or disorders mediated by S1P1 receptors. Such conditions or disorders include multiple sclerosis, autoimmune diseases, chronic inflammatory disorders, asthma, inflammatory neuropathies, arthritis, transplantation, Crohn's disease, ulcerative colitis, lupus erythematosis, psoriasis, ischemia-reperfusion injury, solid tumours, and tumour metastasis, diseases associated with angiogenesis, vascular diseases, pain conditions, acute viral diseases, inflammatory bowel conditions, insulin and non-insulin dependent diabetes.
Patent NZ-582458-A (NZ)
Title: Orally disintegrating tablet compositions of lamotrigine
Inventor: VENKATESH GOPI M
IPC: A01N43/64
Filed: 2008-07-02
Abstract: Disclosed is an orally dissolving or disintegrating (ODT) composition comprising: a therapeutically effective amount of lamotrigine (6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine) and rapidly dispersing granules comprising a disintegrant and a sugar alcohol and/or a saccharide, wherein the composition is formulated such that after administration said composition substantially disintegrates in the oral cavity of a patient and provides a lamotrigine release profile which is substantially the same as the lamotrigine release profile of an immediate release lamotrigine composition wherein the ODT composition delivers at least about 70% of the total dose of lamotrigine upon entering the stomach of the patient and wherein the composition comprises 2 - 200 mg of lamotrigine.
Patent NZ-585367-A (NZ)
Title: Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
Inventor: BONNIN DUSTAN
IPC: C07K1/04
Filed: 2008-10-16
Abstract: Disclosed is a process for manufacturing a composition comprising directed-sequence polymers (DSPs) useful for eliciting immune responses in a subject, comprising the steps of: Selecting a first base peptide sequence, wherein the sequence is an amino acid sequence of an epitope of an antigen associated with a disease treatable by or preventable by vaccination against the epitope and wherein the length of the sequence is at least 6 amino acids; Synthesizing by solid-phase peptide synthesis a first cassette of the DSPs, the cassette having a sequence of amino acid positions corresponding to each amino acid of the first base peptide sequence, wherein for at least one amino acid position of the first cassette, an amino acid is added, the amino acid for each said position being randomly selected from a mixture of amino acids consisting of the original amino acid found at that amino acid position, optionally alanine (A), and optionally, at least one conserved substitution. The composition is capable of inducing an immune response against the base peptide sequence.