baber/WOPTO huggingface dataset:
Patent FI-934752-A0 (FI)
Inventor: ITO FUMITAKA
IPC: A61P25/00
Filed: 1993-10-27
Abstract: Certain novel substituted quinuclidine compounds having the ability to antagonize substance P and having formula (I) wherein Ar<1> and Ar<2> are each, independently, thienyl, phenyl, fluorophenyl, chlorophenyl or bromophenyl; X is -CONR<3>R<4>, -CO2R<3>, -CH2OR<3>, -CH2NR<3>R<4> or -CONR<3>OR<4>; R<1>, R<3> and R<4> are each, independently, hydrogen or alkyl having 1 to 4 carbon atoms; R<2> is alkyl having 1 to 4 carbon atoms; Y is alkylsulfonyl having 1 to 4 carbon atoms, N-alkyl-N-alkanoylamino (which may be substituted by halogen in the alkanoyl moiety) having 1 to 4 carbon atoms in the alkyl and the alkanoyl moieties, N-alkyl-N-alkylsulfonylamino (which may be substituted by halogen in the alkylsulfonyl moiety) having 1 to 4 carbon atoms in the alkyl and the alkyl sulfonyl moieties, alkenyl having 2 to 4 carbon atoms, alkynyl having 2 to 4 carbon atoms, halosubstituted alkyl having 1 to 4 carbon atoms, alkylamino having 1 to 4 carbon atoms, alkanoylamino (which may be substituted by halogen) having 1 to 4 carbon atoms or alkylsulfonylamino (which may be substituted by halogen) having 1 to 4 carbon atoms. These compounds are useful in the treatment gastrointestinal or central nervous system disorders and the alleviation of inflammatory diseases, asthma, pain and migraine in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
Patent FI-941947-A0 (FI)
Inventor: KOPETZKI ERHARD
IPC: C12N15/31
Filed: 1994-04-27
Abstract: PCT No. PCT/EP92/02463 Sec. 371 Date Apr. 28, 1994 Sec. 102(e) Date Apr. 28, 1994 PCT Filed Oct. 28, 1992 PCT Pub. No. WO93/09144 PCT Pub. Date May 13, 1993.The present invention concerns a process for the isolation of recombinant core streptavidin in which host cells are transformed with a DNA coding for core streptavidin, the transformed host cells are cultured under suitable conditions, the DNA coding for core streptavidin is expressed and the recombinant core streptavidin is isolated from the host cells or the culture medium, wherein a DNA coding for core streptavidin is used which has (a) the nucleotide sequence shown in SEQ ID NO. 1 or (b) a nucleotide sequence corresponding to the nucleotide sequence (a) within the scope of the degeneracy of the genetic code.
Patent FI-942826-A0 (FI)
Inventor: GRIJPMA DIRK WYBE
IPC: A61L31/06
Filed: 1994-06-15
Abstract: PCT No. PCT/NL92/00234 Sec. 371 Date Jun. 17, 1994 Sec. 102(e) Date Jun. 17, 1994 PCT Filed Dec. 21, 1992 PCT Pub. No. WO93/13154 PCT Pub. Date Jul. 8, 1993.A copolymer of a lactone and a polycyclic carbonate is prepared by heating a monomer of a lactone with a polycyclic carbonate having two cyclic structures including a carbonate group at elevated temperatures less than 200 degrees Centigrade in the presence of a catalyst. The described copolymers evidence excellent mechanical properties, good resorption velocity and do not disintegrate upon degradation into materials of high crystallinity.
Patent FI-945543-A0 (FI)
Inventor: OUTTRUP HELLE
IPC: C12N9/54
Filed: 1994-11-25
Abstract: PCT No. PCT/DK93/00183 Sec. 371 Date Oct. 26, 1994 Sec. 102(e) Date Oct. 26, 1994 PCT Filed May 26, 1993 PCT Pub. No. WO93/24623 PCT Pub. Date Dec. 9, 1993An alkaline protease has been isolated from Bacillus sp. PD 498 which has a mass of 34 kD by SDS-PAGE, a pH optimum of 9-11, a pI of 9.3, and a temperature optimum of 40 DEG -55 DEG  C. The protease has been formulated into detergent additives and detergents and is suitable for washing processes.
Patent FI-954989-A0 (FI)
Inventor: FISCHER WILFRIED
IPC: A61K9/70
Filed: 1995-10-19
Abstract: Active substance-contg. plaster comprises a carrier and a matrix of a single polymer, and contains vitamin E (or a vitamin E deriv.) and at least one active agent.
Patent FI-960946-A0 (FI)
Inventor: BORCHERS KERSTIN
IPC: G01F23/00
Filed: 1996-02-29
Abstract: The sensor electrode (5) or an electrical conductor connected with it, extends from the first chamber (13) in to the second chamber (14). The walls of the first chamber near the container (2) are designed pressure tight, and a sealing part (19) and a closing organ, seal the passage opening (12) pressure tight. In the first chamber, a sealing part moving axially against the partition (11) is arranged for the passage opening. With an intact probe, it has a position set at a distance from the opening, whilst it closes the partition opening, under the influence of the medium flowing from the container.
Patent IL-73257-A0 (IL)
Title: Quinoline derivatives,their preparation and their use for the protection of plants
IPC: A01N25/32
Filed: 1984-10-16
Abstract: There are used for the protection of cultivated plants against the harmful effects of agricultural chemicals quinoline derivatives of the formula    <IMAGE>  (I)  wherein R1, R2 and R3 independently of one another are each hydrogen, halogen, nitro, cyano, alkyl, alkoxy or acyl, R4, R5 and R6 independently of one another are each hydrogen, halogen or alkyl, X is an aliphatic, saturated or unsaturated, straight-chain or branched-chain hydrocarbon radical which has 1 to 12 carbon atoms and which can be interrupted by one or more hetero atoms or can be substituted by halogen, and Y is hydrogen, halogen, hydroxyl, alkoxy, alkenyloxy, alkynyloxy, a substituted amino group, an ammonio group, a cycloaliphatic radical, a heterocyclic radical which is substituted or substituted by alkyl having 1 to 4 carbon atoms, or is phenyl which is unsubstituted or substituted, or is aryloxy which is unsubstituted or substituted, or is benzyloxy which is unsubstituted or substituted, or is acyloxy, with the inclusion of the acid addition salts and metal complexes thereof; or there are used compositions which contain such derivatives. Also described are novel quinoline derivatives and the production thereof.
Patent IL-74642-A0 (IL)
Title: Pharmaceutical composition constituted by 9alpha,11beta-dichloro-16alpha-methyl-21-oxycarbonyldicyclohexylmethyloxy pregna-1,4-diene-3,20-dione,and an inert excipient
IPC: A61K31/57
Filed: 1985-03-19
Abstract: A novel method of treating inflammation of the colon and rectum of warm-blooded animals comprising administering to the colon and rectum of warm-blooded animals an anti-inflammatorily effective amount of 9 alpha ,11 beta -dichloro-16 alpha -methyl-21-oxycarbonyldicyclohexylmethoxy- DELTA 1,4-pregnadiene-3,20-dione.
Patent IL-75912-A0 (IL)
Title: Alpha amylase assay
IPC: C12Q1/40
Filed: 1985-07-24
Abstract: An  alpha -amylase assay method is described together with a reagent kit for use therein. An oligosaccharide substrate for  alpha -amylase is provided. The substrate contains at least 3 glucose units. Its reducing-end glucose unit is bonded, via a bond cleavable by  alpha - or  beta - glucosidase, to a label which exhibits an optically measurable change upon cleavage of the bond. Its terminal glucose unit is bonded to a blocking substituent which inhibits cleavage by exo-enzymes of the bond between the terminal glucose unit and the adjacent glucose unit. A liquid assay sample is contacted with the oligosaccharide substrate and with an exo-enzyme capable of cleaving the bond between the reducing-end glucose unit and the label. The optically measurable change is used as a measure of  alpha -amylase in the sample.
Patent IL-76895-A0 (IL)
Title: Automatic injection device
IPC: A61M5/24
Filed: 1985-10-31
Abstract: The invention relates to an automatic injection device comprising an assembly of a discharge mechanism (5), a cartridge holder (6) of synthetic material and a cartridge (8) which is slidably accommodated in the cartridge holder, which cartridge comprises a glass ampoule (9), if desired, enveloped by a sheath of shrinkable sheet, said ampoule consisting of an ampoule cylinder (27) in which an injection liquid or various injection liquids separated from each other by stoppers and a piston (11) which can be moved in the ampoule cylinder are provided, a connection means (14) for an injection needle (13) in which or to which the injection needle, if desired, covered by a guard (12) to maintain the needle in a sterile condition, is connected, and a shoulder (29) between ampoule cylinder and needle connection means, the cartridge holder (6) consisting of a sleeve-like rear portion (32) which is open at each end and which, after actuating the injection device, is traversed by the ampoule cylinder and the inner surface of which has substantially the same transverse dimensions over the whole length, and a front portion (30) which forms one assembly with the sleeve-like portion and, after actuating the syringe, serves to discontinue the forward movement of the cartridge in the holder and to allow passage of the needle. The sleeve-like portion (32) of the cartridge holder has a five-sided to fourteen-sided cross-section over a length which is at least equal to the length of the ampoule cylinder and is proportioned in such way that the ampoule cylinder engages the inner side surfaces of said sleeve-like portion with friction. The invention furthermore relates to a cartridge holder for said injection device. ,
Patent IL-84598-A0 (IL)
Title: Pharmaceutical agents containing metal complexes
IPC: A61K47/48
Filed: 1987-11-25
Abstract: The pharmaceuticals contain as additive one or more complexing agent(s) and/or one or more weak metal complex(es) or mixtures thereof.
Patent IL-87982-A0 (IL)
Title: Compositions and methods for manipulating ovulation and spawning in fish
IPC: A61K9/22
Filed: 1988-10-10
Abstract: Administration into fish of gonadotropin releasing hormone (GnRH), luteinising releasing hormone (LHRH) and their analogs in a polymer based sustained release delivery system was found to induce a prolonged elevation in the fish's plasma level of gonadotropin (GtH), which leads to ovulation and spawning. Such induction of ovulation and spawning was found to occur both within the natural spawning season and outside this season. Such administration thus enables for the first time an effective means for manipulating reproduction in fish, which is a very important factor in the economic management of fish farming.
Patent IL-88735-A0 (IL)
Title: Novel 4-chloro-3-sulfamoylbenzoic acid hydrazides,a process for the preparation thereof,pharmaceutical compositions containing them and their use as medicaments
IPC: A61K31/415
Filed: 1988-12-20
Abstract: The novel compounds according to the invention correspond to the general formula I 
<IMAGE>
 in which
 R represents hydrogen, a trifluoromethyl or carboxyl group, an alkoxycarbonyl group having 2-5 carbon atoms, a cyano, benzoyl or sulphamoyl group or an alkylsulphonyl group having 1-4 carbon atoms,
 R<1> represents hydrogen, an alkylthio or alkylsulphonyl group each having 1-4 carbon atoms, a straight or branched alkyl group having 1-4 carbon atoms, or a benzylthio, benzylsulphonyl, phenyl, hydroxyl or thiol group and
 R<2> represents hydrogen or chlorine. 
<??>The novel compounds act as diuretics and saluretics and have a hypotensive action.
Patent IL-89883-A0 (IL)
Title: Protection of stony materials from atmospheric agents by use of aqueous emulsions of perfluoropolyether derivatives
IPC: C09K3/18
Filed: 1989-04-07
Abstract: There is described a process for protecting marble, stone, tiles, cement and analogous materials, utilized in the building industry, from the action of atmospheric agents and polutants, by applying to the surface of the material a microemulsion of perfluoropolyethers, optionally having at one end or at both ends or in the chain functional groups capable of acting as anchoring agents to the substrate.
Patent IL-92239-A0 (IL)
Title: Magnetic compass
IPC: G01C17/38
Filed: 1989-11-07
Abstract: An electronic compass system for determining the heading of an armored vehicle containing a large mass of ferromagnetic material, which system comprises a plurality of sensors, and for real-time computation of the corrections required of actual magnetometer measurements. Part of the values used for the computation are computed in advance, and part in real-time. Some of the computations are based on the perturbation of the earth magnetic field based on an algorithm which takes into account one or two rotational prolate ferromagnetic ellipsoids which have certain dimensions and which are at a predetermined distance from each other either represent the body of an armored vehicle, or when two ellipsoids are used, they represent the hull and turret of a tank.
Patent FI-20002524-A0 (FI)
IPC: F27D21/00
Filed: 2000-11-17
Abstract: The invention relates to a device for moving the belt of a belt conveyor used in continuously operated belt sintering between the drawing drum and the folding drum, and for aligning the belt sintering belt to be moved by the belt conveyor with respect to the sintering device. According to the invention, in order to rotate the drawing drum (2) of the belt conveyor used in belt sintering, in the immediate vicinity of the other end of the drawing drum, there is installed an actuator device (5, 6, 8) of the belt conveyor, where in at least one rotary element (5) that is installed co-centrically with the axis (15) of the drawing drum and cogged on the outer circumference, there is connected at least one actuator element (6) that is essentially smaller in diameter and cogged on the outer circumference, which actuator element (6) can be made to rotate by means of an actuating motor (8) belonging to the actuator device. Moreover, in order to align the belt (1) of the belt conveyor with respect to the sintering device (4), the actuator device of the belt conveyor is installed, with respect to the belt conveyor, so that the aligning of the belt (1) of the belt conveyor can, when necessary, be carried out essentially by moving the whole actuator device (5, 6, 8) of the belt conveyor.
Patent FI-20041582-A0 (FI)
Inventor: JUNTUNEN HARRI
IPC: E05F/
Filed: 2004-12-08
Abstract: The valve made from acrylonitrile butadiene styrene, has protruding flange (10) for seating against a door closer piston (11) while simultaneously creating a seal around a mounting hole (12) in the piston. Oil is supplied through the mounting hole to control door closer. - An INDEPENDENT CLAIM is also included for piston assembly for door closer.
Patent IL-100084-A0 (IL)
Title: Retroviral protease inhibitors
IPC: A61K31/535
Filed: 1991-11-19
Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Patent IL-113026-A0 (IL)
Title: Selective antagonists of the human nk3 receptor, their preparation and pharmaceutical compositions containing them
IPC: C07D211/22
Filed: 1995-03-17
Abstract: N-(3,4-dichlorophenyl-propyl)-piperidine derivs. of formula (I) and their salts are new. Ar = pyrid-2-yl or phenyl (opt. substd. by halo, methyl or (1-4C)alkoxy); R1 = methyl; R11 = H; or R1+R11 = -(CH2)3-; R2 = (1-7C)- alkoxy, acryloxy, acyl, allkoxycarbonyl, alkoxymethyl, acyloxymethyl or alkylamino-carbonyloxymethyl, or CN, -CH2OH, OH, -NR6R7, -NR3COR4, -NR3COOR8, -NR3SO2R9, -NR3CONR10R12, -CONR10R12, -CH2NR13R14, -CH2NR3COR4, -CH2NR3COOR8, -CH2NR3SO2R9 or -CH2NR3CONR10R12, or R2 forms a double bond between the C to which it is attached and the adjacent C in the piperidine ring; or CR2Ar = a gp. (i); R3 = H or (1-4C) alkyl; R4 = H, (1-7C)alkyl, phenyl, benzyl, pyridyl or (3-7C)cycloalkyl (opt. substd. by one or more methyl); or R3+R4 = -(CH2)n-; n = 3 or 4; T = methylene, carbonyl, -COO- or -CONR5-; A = a bond, methylene, ethylene, propylene or vinylene; or -T-A- = -SO2-; Z = phenyl (opt. substd. by one or more halo, (1-4C)alkyl or alkoxy, or nitro); R5 = H or (1-4C)alkyl; R6 = H or (1-7C)alkyl; R7 = H, (1-7C)alkyl, (3-7C)cycloalkylmethyl, benzyl or phenyl; or NR6R7 = azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine or perhydroazepine; R8 = (1-7C)alkyl or phenyl; R9 = (1-7C)alkyl, or amino (opt. substd. by one or two (1-7C)alkyl), phenyl (opt. substd. by one or more (1-7C)- alkyl, alkoxy, alkoxycarbonyl or alkylcarbonyloxy, or halo, CF3, hydroxy, carboxy, cyano, nitro or amino (opt. substd. by one or two (1-7C)alkyl)); R10 = H or (1-7C)alkyl; R12 = H, (1-7C)alkyl, (3-7C) cycloalkyl or cycloalkylmethyl, hydroxy, (1-4C)alkoxy, benzyl or phenyl; or NR10R12 = a heterocyclic gp. as for NR6R7; R13 = H or (1-7C)alkyl; R14 = H, (1-7C)alkyl, (3-7C)cycloalkylmethyl or benzyl; with the provisos that: a) when Ar = phenyl, R2 = hydroxy and T-A-Z = benzoyl, then R1 is not methyl; b) when Ar = phenyl, R2 = -NH-CO-CH3 and T-A-Z = benzoyl or 3-methoxybenzyl then R1+R11 is not -(CH2)3-. Also claimed are the piperidine derivs. of formula (V) and their salts. R2' = -NR3COR4; R3, R4 are as defined except when R3 = H then R4 is not methyl; Y = H or a protective gp.. Also claimed is the starting material of formula (1') and its acid addn. salts, pref. the (+) isomer.
Patent IL-123801-A0 (IL)
Title: A gas compressor
IPC: F04B9/08
Filed: 1998-03-23
Abstract: PCT No. PCT/GB93/01137 Sec. 371 Date Nov. 29, 1994 Sec. 102(e) Date Nov. 29, 1994 PCT Filed May 28, 1993 PCT Pub. No. WO93/24754 PCT Pub. Date Dec. 12, 1993A gas compressor is provided comprising a chamber (9) to contain gas to be compressed, a piston (12) and the chamber (9) and an apparatus to drive the piston into the chamber (9) to compress the gas. The compressor also comprises another apparatus (5) to form a spray of liquid in the chamber (9) to cool the gas on compression therein, so that the gas may be compressed approximately isothermally. Valve (17) are provided to allow compressed gas to be drawn from the chamber. The apparatus to drive the piston (12) comprises another apparatus to deliver driving energy stored in the fluid directly to the piston. In one embodiment, the driving energy is provided by a combustible fuel. The heat of compression is rejected at the lowest temperatures and the hot exhaust gas from the combustion process may be used to preheat the isothermally compressed gas.
Patent IL-125805-A0 (IL)
Title: Use of a pharmaceutical composition comprising an appetite-suppressing peptide
IPC: A61P3/00
Filed: 1997-02-27
Abstract: A claimed composition comprises a peptide of formula (I), given in one letter amino acid code, and an appetite-suppressing or satiety-inducing agent, preferably administered with glucagon-like peptide (GLP)-1. X1HX2DGSFSDEMNTX3LDX4LAX5X6DFINWLX7X8TKITDX9 (I) X1 = absent, DFPEEVAIVEELGRR, DFPEEVTIVEELGRR, or a fragment of these; X2 = A or G; X3 = I or V; X4 = N, S or H; X5 = A or T; X6 = R or K; X7 = I or L; X8 = Q or H; X9 = absent, K, R, RK, KR, RR or KK. Also claimed is the use of a composition comprising a peptide of formula (I) for: (a) appetite suppression or satiety induction; and (b) prophylaxis and treatment of obesity or type II diabetes.
Patent IL-130669-A0 (IL)
Title: Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
IPC: A61K31/337
Filed: 1997-12-29
Abstract: The present invention is directed to novel taxoids possessing strong reversing activities for drug-resistance associated with anti-cancer agents, the preparation of these reversal agents and pharmaceutical compositions thereof. The new taxoids of the present invention have the formula (I).    <IMAGE>  I
Patent IL-137989-A0 (IL)
Title: Optical fiber filters and method of making the same
IPC: G02B6/34
Filed: 2000-01-03
Abstract: An optical fiber filter is produced which has a sinusoidal response or a modulated sinusoidal response with any desired amplitude and wavelength period. This is achieved by first producing an elongated adiabatic taper in a single-mode fiber which has been stripped of its protective jacket. Then, on the slope of this adiabatic taper, at each end of the central zone, there is formed a non-adiabatic taper such as to obtain a predetermined sinusoidal or modulated sinusoidal response in the filter.
Patent IL-141438-A0 (IL)
Title: Method of increasing the bioavailability and tissue penetration of azithromycin
IPC: A61K31/765
Filed: 2001-02-15
Abstract: The bioavailability of azithromycin can be increased by co-administering azithromycin with a p-glycoprotein (p-gp) inhibitor. The azithromycin and p-gp inhibitor can be administered together in a composition or as separate components. If administered separately, they can be embodied as a kit.
Patent IL-144236-A0 (IL)
Title: Tetrahydropyran derivatives and their use as therapeutic agents
IPC: C07D405/14
Filed: 2000-03-16
Abstract: The present invention relates to compounds of the formula (I):wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis and postherpetic neuralgia.
Patent IL-146338-A0 (IL)
Title: Process of rapid variety-independent plant transformation
IPC: C12N15/09
Filed: 2000-05-17
Abstract: Disclosed is a method of making transgenic plants. Heterologous DNA is first introduced into a donor plant, plant cell or protoplast, and then moved from the donor to a recipient plant, plant cell or protoplast unaccompanied by any native genomic DNA of the donor. The donor and recipient are chosen that produce unstable progeny or demonstrate preferential segregation or sorting out. The DNA may be inserted randomly or at specific locations in the genome of the recipient plant. Also disclosed are transgenic plants produced by the methods, and plant progeny, plant parts and seeds and seed parts from the plants.
Patent IL-146962-A0 (IL)
Title: Aminotetralin derivatives for the therapy of cardiovascular diseases
IPC: A61K31/222
Filed: 2000-06-07
Abstract: The invention relates to a method of treatment of left ventricular dysfunction, by administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof.
Patent IL-148961-A0 (IL)
Title: Sensor line
IPC: D06H3/08
Filed: 2002-04-01
Abstract: At least one sensor strip is mounted at 90 deg  to the transport direction of the fibre material and consists several CMOS or CCD elements. Each element features at least 20 pixels. Three sensor strips can be mounted in a racked arrangement and connected to a joint evaluation system.
Patent IL-152470-A0 (IL)
Title: Pharmaceutical composition comprising micronised formoterol and micronised glucocorticosteroid
IPC: A61P11/00
Filed: 2001-05-17
Abstract: The invention relates to a process for preparing a novel pharmaceutical composition useful in the treatment of respiratory disorders such as asthma, rhinitis and chronic obstructive pulmonary disease (COPD).
Patent IL-153561-A0 (IL)
Title: 4-alkoxy cyclohexane-1-amino carboxylic acid esters and method for the production thereof
IPC: C07C229/48
Filed: 2001-06-22
Abstract: The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for their preparation and to their use as intermediates in the synthesis of insecticidal, acaricidal and herbicidal compounds or pharmaceutically active compounds.
Patent IL-154361-A0 (IL)
Title: Method and device for measuring a line attenuation
IPC: H04B3/48
Filed: 2001-08-10
Abstract: Accordingly, the invention relates to a process and a device for measuring the attenuation of a line where the measurement process according to the invention makes it possible to measure the attenuation of a line at a given frequency F and includes at least the steps wherein the emission of an electric signal at one end of the electric line, provides a signal that includes a spectral amplitude A1 at the frequency F; the measurement of the signal reflected by the other end of the line, at the end of the line from where the signal was emitted; the determination of the amplitude A2 of the spectral component at the frequency F of the reflected signal; the determination of the attenuation of the line from the ratio of the amplitude A2 to the amplitude A1 where it applies in particular to the rating of asymmetric digital subscriber lines.