Patent SG-11201803865X-A (SG)
Title: An oral drug formulation comprising silybin
Inventor: DE IASI GIANLUCA
IPC: A61P1/16
Filed: 2016-11-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau rist0) (43) International Publication Date .... ....r .....1 18 May 2017 (18.05.2017) WIPO I PCT II (10) WO International 11111111111111111111111111111111111111111111111111111111111111111t111111111111111 2017/081140 Publication Number Al (51) International Patent Classification: (71) Applicant: ISTITUTO BIOCHIMICO ITALIANO A61K 36/28 (2006.01) A61P 1/16 (2006.01) GIOVANNI LORENZINI S.P.A. [IT/IT]; Via Fossig- nano, 2, 04011 Aprilia (IT). (21) International Application Number: PCT/EP2016/077246 (72) Inventors: DE IASI, Gianluca; Via dei Bersaglieri, 27, 04011 Aprilia (IT). FEOLA, Monica; Vicolo del La- (22) International Filing Date: 10 November 2016 (10.11.2016) ghetto, 23, 00040 Castel Gandolfo (IT). DI MANZANO, Carlo Maria; Via Di Valle Nicosia, 3, 00046 Grottaferrata (25) Filing Language: English (IT). (26) Publication Language: English (74) Agents: CATTANEO, Elisabetta et al.; NOTARBARTO- LO & GERVASI S.P.A., Corso di Porta Vittoria 9, 20122 (30) Priority Data: Milano (IT). 102015000071933 12 November 2015 (12.11.2015) IT (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, [Continued on next page] (54) Title: AN ORAL DRUG FORMULATION COMPRISING SILYBIN (57) : The invention relates to an oral phai inaceutical formulation com- Age vs Sex prising a milk thistle extract of silybin with a purity higher than 80% phosphol - CO- ipids, sorbitol and carragenin, wherein the weight ratio between the amount of 55- silybin and the amount of phospholipids is in the range of 1:1.50 and 1:2. 59- 45- ti, 40- - 35-1 2 3D- 25- 20- 15 Mile Pen tile Figure 1 3X 3 4 Figure 2 tira -at 2222 11 .4t o i t 11 I I Il 0 IN I'l 0 ei Ge rears 12 Figure 3 O WO 2017/081140 Al MIDEDIMOMOIDIONOIDEMONIMMEDIEMEIONMEHOIMIE BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — as to applicant's entitlement to a patent (Rule 4.17(0) apply for and be granted — of inventorship (Rule 4.17(iv)) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Published: — with international search report (Art. 21(3))