baber/WOPTO huggingface dataset:
Patent CA-2963362-A1 (CA)
Title: Methods of isolating t cell receptors having antigenic specificity for a cancer-specific mutation
Inventor: TRAN ERIC
IPC: A61K39/00
Filed: 2014-10-02
Abstract: Disclosed are methods of isolating a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; selecting the autologous T cells; and isolating a nucleotide sequence that encodes the TCR from the selected autologous T cells, wherein the TCR has antigenic specificity for the mutated amino acid sequence encoded by the cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.
Patent CA-2968554-A1 (CA)
Title: Foldable ladder
Inventor: KIEFFER MITCHELL I
IPC: E06C1/12
Filed: 2015-12-02
Abstract: A foldable ladder has a first ladder portion and a second ladder portion hingedly attached to the first ladder portion by a pair of hinge mechanisms. Each hinge mechanism adapted to lock the first and second ladder portions such that the first ladder portion and the second ladder portion form an angle therebetween. The hinge mechanism has a shifting mechanism and a ladder angle selector coupled thereto to allow manual selection of the angle between the first and second ladder portions, and a locking pin to lock the first and second ladder portions at an angular position.
Patent CA-2969167-A1 (CA)
Title: Poudre de lait a sensation en bouche amelioree
Inventor: KREUSS MARKUS
IPC: A23J3/08
Filed: 2015-12-21
Abstract: L'invention concerne une poudre de lait comprenant des caséines et des protéines de lactosérum qui, lors de sa reconstitution en milieu aqueux, renferme des agrégats de caséine-protéine de lactosérum/matières grasses présentant une valeur moyenne de diamètre Dv50 d'au moins 1 micron, telle que mesurée par diffraction laser. L'invention concerne également un procédé de préparation de poudre de lait consistant à utiliser un concentré de lait liquide à T < 25 °C, à ajuster le pH entre 5,7 et 6,4, à chauffer entre 80 et 150 °C pendant 3 à 300 s, à refroidir à une température inférieure à 70 °C et éventuellement à effectuer un nouvel ajustement du pH entre 6,5 et 6,8; à sécher la composition et la poudre de lait obtenues par ce procédé pour produire des laits de croissance, des sauces culinaires, des mélanges de café, un colorant à thé et à café ou des boissons maltées cacaotées.
Patent CA-2971220-A1 (CA)
Inventor: KHLEIF SAMIR
IPC: C07K19/00
Filed: 2015-12-18
Abstract: Disclosed herein are compositions comprising use of compositions comprising a live attenuated recombinant Listeria strain comprising a fusion protein of a truncated listeriolysin O (LLO) protein, a truncated ActA protein, or a PEST amino acid sequence fused to a heterologous antigen, including a tumor-associated antigen, wherein the compositions further comprise or are co-administered with an antibody or fragment thereof. Also disclosed are combination therapies comprising use of these compositions comprising live attenuated recombiant Listeria strains, in conjuction with an antibody or fragment thereof for use in treating, protecting against, and/or inducing an immune response against a tumor, especially wherein the treating, protection against and/or inducing an immune response increases percent survival in a subject.
Patent CA-2972218-A1 (CA)
Title: Label, device, system and method for sorting bolts.
Inventor: COURNOYER MICHEL
IPC: B07C5/342
Filed: 2017-06-23
Abstract: The present invention relates to label, device, system and method for sorting bolts, bars, pins, studs, dowels, screws or the like (collectively and individually described herein as a bolt). The bolts are being characterized by a first and a second dimension. The identification system comprises a color chart defining all ten numerals and most commonly used bolt diameters corresponding to various colors and an identification label. The identification label comprises a main section and at least one other section being both adapted to receive at least one color and/or a numeral. Each combination of a color and a numeral being defined by the color chart. The combination of colors and/or numerals of the main section defines the first dimension of the bolt and the combination of colors and/or numerals of the at least one other section defines the second dimension of the bolt.
Patent CA-2973129-A1 (CA)
Inventor: AHMED MALLIK
IPC: A47J37/04
Filed: 2016-01-15
Abstract: A charcoal pan includes a supporting surface for supporting a quantity of charcoal beneath a cooking grate, and a plurality of diffusers that transport air from underneath the supporting surface to an area above at least a portion of the quantity of charcoal.
Patent CA-2973904-A1 (CA)
Inventor: LAFRANCE CHRISTIAN
IPC: G06Q10/08
Filed: 2016-01-19
Abstract: A system and method are provided for managing and optimizing delivery networks. The method includes providing an intermediary between a consumer and a plurality of carriers, each carrier enabling items to be transported from pick up locations for the items to a delivery location associated with the consumer. The method also includes enabling, via a user interface for the intermediary, the consumer to request delivery of an order comprising one or more items to the delivery location. The method also includes communicating with the plurality of carriers to determine at least one available delivery time window according to carrier availability and a transit time for the requested delivery, the transit time being affected by inventory data and the delivery location. The method also includes initiating the delivery by a selected one of the plurality of carriers.
Patent CA-2974523-A1 (CA)
Inventor: SUBHEDAR VINIT V
IPC: A47C27/04
Filed: 2016-01-22
Abstract: A process and apparatus for manufacturing a mattress generally includes an automated foam layer placement apparatus for accurately securing one or more foam layers onto an innercore unit and bucket assembly.
Patent CA-2975159-A1 (CA)
Inventor: MOSHER TIMOTHY EDWARD
IPC: G01N21/898
Filed: 2017-08-03
Abstract: A scanner system comprising a plurality of scanners which are spatially separated in both transverse and longitudinal directions relative to a workpiece flow in the longitudinal direction, the scanners adapted to produce corresponding scanned image data, a transport which moves workpieces in a workpiece flow, the transport including lateral curves in the transverse direction so the transport does not occlude a field of view of the scanners, wherein a first field of view of each scanner spatially separated in the longitudinal direction from a laterally adjacent scanner having a second field of view is adjacent to and abuts against the second field of view, so that the scanned image data produced by each scanner of the plurality of scanners abuts the scanned image data produced by the laterally adjacent scanner, whereby the scanned image data produced by each scanner of the plurality of scanners does not include overlapping image data.
Patent CA-2975433-A1 (CA)
Inventor: BURKS JODY MARIE
IPC: C09K8/80
Filed: 2015-03-12
Abstract: This present application relates generally to enhancing flow of fluids during fracturing operations. More specifically, the application relates to providing a proppant with a low surface energy, introducing the proppant into a subterranean formation with a surfactant selected to interact with the proppant such that the recovery of hydrocarbons from the subterranean formation is enhanced.
Patent CA-2976577-A1 (CA)
Title: Procede base sur les microarn pour la detection precoce du cancer de la prostate dans des echantillons d'urine
Inventor: THOMSEN RONFELDT ANNI
IPC: C40B30/04
Filed: 2016-02-05
Abstract: La présente demande concerne un nouveau procédé in vitro pour évaluer le risque qu'un sujet souffre d'un cancer de la prostate. Le procédé consiste à mesurer le niveau d'expression d'au moins deux miARN choisis dans le groupe de miARN constitué par : hsa-let-7a-5p, hsa-let-7b-5p, hsa-let-7c-5p, hsa-let-7e-5p, hsa-let-7f-5p, hsa-let-7g-5p, hsa-miR-100-5p, hsa-miR-106a-5p, hsa-miR-10a-5p, hsa-miR-10b-5p, hsa-miR-1238-3p, hsa-miR-125b-5p, hsa-miR-1260a, hsa-miR-130a-3p, hsa-miR-132-3p, hsa-miR-135a-5p, hsa-miR-135b-5p, hsa-miR-136-5p, hsa-miR-140-3p, hsa-miR-141 -3p, hsa-miR-142-3p, hsa-miR-146a-5p, hsa-miR-148a-3p, hsa-miR-151 a-3p, hsa-miR-151 a-5p, hsa-miR-15b-5p, hsa-miR-16-5p, hsa-miR-191 -5p, hsa-miR-1972, hsa-miR-19a-3p, hsa-miR-19b-3p, hsa-miR-200a-3p, hsa-miR-200b-3p, hsa-miR-200b-5p, hsa-miR-200c-3p, hsa-miR-203a, hsa-miR-204-5p, hsa-miR-205-5p, hsa-miR-20a-5p, hsa-miR-210, hsa-miR-222-3p, hsa-miR-223-3p, hsa-miR-22-5p, hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-24-3p, hsa-miR-25-3p, hsa-miR-26a-5p, hsa-miR-27b-3p, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-30a-3p, hsa-miR-30a-5p, hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-30e-5p, hsa-miR-31 -3p, hsa-miR-31 -5p, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, hsa-miR-331 -3p, hsa-miR-362-3p, hsa-miR-362-5p, hsa-miR-363-3p, hsa-miR-375, hsa-miR-378a-3p, hsa-miR-425-3p, hsa-miR-425-5p, hsa-miR-455-3p, hsa-miR-490-3p, hsa-miR-660-5p, hsa-miR-93-5p, hsa-miR-99a-5p et hsa-miR-99b-5p dans un échantillon d'urine du patient. Un procédé dans lequel lesdits au moins deux miARN choisis sont : hsa-miR-30c-5p, hsa-miR-222-3p et hsa-miR-24-3p est préféré. La demande concerne également un kit de pièces pour mettre en uvre le procédé in vitro.
Patent CA-2977923-A1 (CA)
Inventor: PURDY CLAY
IPC: C09K8/528
Filed: 2017-09-01
Abstract: The present invention discloses a novel aqueous composition for use in removing barium sulfate scale from a surface contaminated with such, said composition comprising: a chelating agent and a counterion component selected from the group consisting of: Li5DTPA; Na5DTPA; K5DTPA; K5DTPA + 10wt% K2CO3; Cs5DTPA; Na4EDTA; K4EDTA; TEAH4DTPA; and TBAH5DTPA; and a scale removal enhancer. There is also disclosed rnethods to use such compositions.
Patent CA-2980497-A1 (CA)
Title: Phase modulator for fiber-optic gyroscopes controlled in a zero-mean manner and a fiber-optic gyroscope
Inventor: SPAHLINGER GUNTER
IPC: G01C19/72
Filed: 2016-03-23
Abstract: The invention relates to a control system (100) for a fiber optic gryoscope, comprising a phase modulator (110) for modulating a phase of a light signal (115) and a control unit (120) for producing a control signal (125), by the value of which the phase is modulated and which is fed to the phase modulator (110). The control signal changes statistically and does not have an average value.
Patent CA-2981884-A1 (CA)
Title: Doses unitaires, compositions et schemas therapeutiques pour administrer a des surfaces keratiniques des agents de stimulation des voies favorisant la resolution d'une inflammation
Inventor: Donald collins
IPC: A61K8/02
Filed: 2016-04-15
Abstract: L'invention concerne une ampoule contenant un agent de stimulation des voies favorisant la résolution d'une inflammation, des procédés de fabrication de ladite ampoule, et des procédés de traitement de la peau comportant des zones discrètes d'inflammation à l'aide d'une composition en ampoule contenant un agent de stimulation des voies favorisant la résolution d'une inflammation.
Patent CA-2984047-A1 (CA)
Inventor: HEDARCHET STEPHANE ANTONY
IPC: A24F40/65
Filed: 2016-05-23
Abstract: L'invention concerne un procédé de commande d'un système électrique de génération d'aérosol. Le procédé consiste: à recevoir une entrée d'un usager, sous la forme d'une demande d'ajustement d'un premier paramètre du système; à comparer l'entrée à une fourchette de valeurs admissibles pour le premier paramètre; à produire un signal d'autorisation indiquant que l'entrée est dans la fourchette de valeurs admissibles pour le premier paramètre; à déterminer un ajustement à une fourchette de valeurs admissibles pour un second paramètre, en fonction du premier paramètre et de l'entrée; et à ajuster le premier paramètre et la fourchette de valeurs admissibles pour le second paramètre, en fonction du signal d'autorisation. L'invention concerne également un dispositif électrique de génération d'aérosol (400) qui comprend des circuits de commande (404) configurés pour mettre en uvre le procédé de commande. Elle concerne en outre un support de stockage pour stocker des valeurs paramétriques préétablies, et un dispositif d'affichage électronique (300) pour afficher les valeurs paramétriques et leur relation.
Patent CA-2984778-A1 (CA)
Inventor: TREMBLY JASON PATRICK
IPC: C02F1/02
Filed: 2016-05-04
Abstract: A supercritical vessel (30) for separating dissolved solids from a fluid solution includes a main body (40) defining a separation chamber (48) adapted to contain a fluid solution while the fluid solution is heated to a supercritical temperature so as to produce a supercritical fluid (58) from which dissolved solids precipitate. The vessel (30) further includes a fluid inlet (34) for receiving fluid solution, a fluid outlet (54) for discharging supercritical fluid (58), and a precipitate outlet (50) for discharging precipitated solids (60). The main body (40) is tilted at a tilt angle (T) relative to horizontal (P) such that the fluid inlet (34) is positioned vertically higher than the fluid outlet (54) and the precipitate outlet (50), so as to induce movement of the precipitated solids (60) in a downward direction toward the precipitate outlet (50). The fluid inlet (34) may be positioned proximate a first end (42) of the main body (40), and the fluid outlet (54) and precipitate outlet (50) may be positioned proximate a second end (44).
Patent CA-2987787-A1 (CA)
Inventor: HORN GERALD
IPC: A61P27/02
Filed: 2016-06-09
Abstract: The invention provides compositions and methods for the improvement of distance vision. The invention further provides compositions and methods for the treatment of refractive errors of the eye, such as presbyopia. The invention further provides ophthalmological compositions that comprise from about 1.35% to about 2.0% w/v of aceclidine and from about 2.25%  to about 2.75% w/v of a polyol.
Patent CA-2989576-A1 (CA)
Inventor: DEERING ERIC
IPC: H05K3/12
Filed: 2016-06-15
Abstract: Systems and methods for lighting system lens heating are described. The systems and methods include a substantially clear thermoplastic substrate; and a conductive ink or film circuit on the thermoplastic substrate.
Patent CA-2990272-A1 (CA)
Inventor: HEDLEY ROBERT IAN
IPC: B60B30/10
Filed: 2016-07-01
Abstract: An apparatus (10) for fitting and/or removing wheel nuts. The apparatus (10) includes a base structure that supports a movable wheel engaging portion, the wheel engaging portion including a socket wrench (23) and a positioning device, wherein the positioning device can be used to locate the wheel engaging portion to aid the socket wrench (23) to fit or remove a wheel nut.
Patent CA-2992339-A1 (CA)
Title: Micro grid control system
Inventor: RODRIGUEZ RIGOBERTO JORGE
IPC: H02J13/00
Filed: 2018-01-18
Abstract: A micro grid power control system may control a plurality of different sources of electrical energy, such as generators, renewable energy sources, and stored energy sources. The micro grid power control system may include hierarchical levels of control. At a system level, the micro grid power control system may include a system controller configured to selectively allocate the sources and centrally control electrical distribution of electric power within the micro grid based on system conditions to optimize system operation. Optimization of system operation may be dynamically varied by the system controller based on priorities and modeling of system operation. At a source level, each of the sources may include a source controller configured to optimize generation of electrical energy of the respective source. Optimization of a source with a respective source controller may be based on a source objective independently associated with each of the sources and source modeling.
Patent CA-2992368-A1 (CA)
Inventor: AGUSTIN MACIA BARBER
IPC: A61B5/00
Filed: 2016-07-14
Abstract: An adaptive noise quantification system and associated methods are disclosed for use in the dynamic biosignal analysis of a user. In at least one embodiment, the system includes a biosignal sensor positioned and configured for obtaining and transmitting data related to a select at least one vital of the user as a biosignal, and a motion sensor positioned and configured for obtaining and transmitting data related to a motion level of the user as a motion signal. A computing device is configured for receiving and processing the biosignal and motion signal.
Patent CA-2992390-A1 (CA)
Inventor: LOUREIRO NUNO
IPC: G06F3/01
Filed: 2016-07-13
Abstract: A method, system and computer readable media for a BMI using a fixed decoder based on ratios of different frequency bands, making the decoder robust, less jittery, and resistant to artifacts. The fixed decoder can be configured to use a limited subset of available channels. The decoder can therefore be optimized for each human subject (frequency bands to use, ratios to process the received signals, which channels, weights, etc.) and then fixed. Output from the fixed decoder can be provided to a training program that implements specific feedback and training parameters, thereby enabling subjects to learn to control devices rapidly, as well as consolidate this control. The training program provides continuous feedback of the current transformation being output by the fixed decoder in conjunction with feedback of the past transformations (e.g., up to a second before) and saliency of the feedback when goals of the task are achieved.
Patent CA-2993460-A1 (CA)
Inventor: CARULLO ANNE
IPC: A61K8/02
Filed: 2016-07-14
Abstract: A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a time when the gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; and methods for treating skin and methods for making a sheet pack.
Patent CA-2999065-A1 (CA)
Title: Priming device
Inventor: YEH JONATHAN
IPC: A61M39/26
Filed: 2016-09-09
Abstract: Described is a priming device (100) to prime a gas from a fluid delivery system by receiving the gas and a fluid used to push the gas into a chamber (108), the priming device including a cover body (104) having a lid (106), and a housing (102) having a chamber, an inlet port (110) and an opening to release gas received into the chamber. The device has a priming-ready configuration where the medical connector and the housing are coupled with the cover body, and the fluid path of the medical connector and the passage of the housing remain sealed, a priming configuration where the medical connector is advanced in the cover body to fluidly couple with the housing, and a post-priming configuration where the housing is decoupled from the cover body and the lid closed to prevent contamination of the medical connector.
Patent CA-2999808-A1 (CA)
Inventor: STROMSOE ROGER ARNOLD
IPC: E02D3/026
Filed: 2016-09-23
Abstract: The invention relates to an impact compactor which includes a first part on which at least one non-round compactor drum is rotatably mounted; and a second part which is connected to, and movable relative to, the first part. The impact compactor also includes a damping arrangement which is connected between the first and second parts and which is configured to provide a damping function for the relative movement between the first and second parts. The damping arrangement includes an outer tubular member which defines a non-circular inner channel/passage; a non-circular inner shaft member which defines a first axis of rotation and which is positioned, at least partially, in the channel/passage defined by the outer tubular member; and at least one wedge formation which is wedged between the shaft member and the tubular member. The wedge formation is at least partially resiliently deformable and is configured to resist/oppose relative rotation between the shaft member and the tubular member about the first axis of rotation. One of the members is connected to the first part, while the other member is connected to the second part.
Patent CA-2999869-A1 (CA)
Inventor: RICHARDS TIMOTHY
IPC: G07F19/00
Filed: 2016-09-22
Abstract: Methods, systems and apparatus are provided for facilitating financial transactions using an IC type financial card via a terminal. Upon insertion of an IC card to the terminal, a requested funds access transaction is processed via a first selected transaction type. If the transaction is unsuccessful, the terminal automatically presents a list of remaining available transaction types from which the user may select and the transaction is processed by the next selected transaction type, without removal of the card between the two attempts. If the transaction is successful, funds are provided to the user, such as in the form of currency/coins or funds transfer.
Patent CA-3005048-A1 (CA)
Title: Compositions seches stables ne presentant pas ou peu de sucres
Inventor: KESHTMAND MAJID
IPC: A23L33/135
Filed: 2016-11-30
Abstract: La présente invention concerne une composition sèche stable. La composition comprend un ou plusieurs micro-organismes viables, au moins 50 % en poids d'une ou de plusieurs protéines hydrolysées et moins de 10 % en poids d'un ou de plusieurs sucres sélectionnés parmi le groupe comprenant les monosaccharides, les disaccharides et leurs combinaisons, chaque pourcentage en poids étant basé sur le poids total de la composition sèche. De préférence, la composition ne comprend pas de monosaccharide ou de disaccharide. La composition peut en outre comprendre un ou plusieurs oligosaccharides, un ou plusieurs polysaccharides, un ou plusieurs sels d'acide carboxylique, ou une de leurs combinaisons. La composition peut présenter une viabilité d'au moins 1 X 1010 CFU/g, et une perte de viabilité inférieure à 1 unité log/g après 84 jours à une température de 40 °C et une humidité relative de 33 %. L'invention concerne également des procédés permettant de préparer la composition sèche stable.
Patent CA-3006422-A1 (CA)
Title: Vanne de regulation de debit de fond de trou autonome pour controle de pression de puits
Inventor: GREEN ANNABEL
IPC: E21B43/12
Filed: 2016-11-28
Abstract: L'invention concerne un dispositif de régulation de débit de fond de trou (10) ayant une vanne de régulation de débit (30) et un capteur (50) en communication avec la vanne de régulation de débit. Le capteur mesure un paramètre de traitement aval et la vanne de régulation de débit est configurée pour commander l'écoulement de fluide à travers la vanne afin d'obtenir une valeur de paramètre de traitement aval cible en réponse au paramètre de traitement aval mesuré. L'invention concerne également un système de commande pour commander le dispositif de régulation de débit de fond de trou et un procédé de commande du dispositif d'écoulement de fond de trou.