Patent SG-11201901673S-A (SG)
Title: Imidazole derivatives and their use in the treatment of autoimmune or inflammatory diseases or cancers
Inventor: BAXTER ANDREW
IPC: C07D405/14
Filed: 2017-08-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111 1111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/041947 Al 08 March 2018 (08.03.2018) WI P0 I P C T (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every CO7D 401/14 (2006.01) A61K 31/444 (2006.01) kind of regional protection available): ARIPO (BW, GH, CO7D 405/14 (2006.01) CO7D 401/04 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, A61K 31/443 (2006.01) A61P 29/00 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61K 31/4433 (2006.01) A61P 35/00 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 31/4439 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/EP2017/071868 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 31 August 2017 (31.08.2017) Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a (25) Filing Language: English patent (Rule 4.17(ii)) (26) Publication Language: English — as to the applicant's entitlement to claim the priority of the (30) Priority Data: earlier application (Rule 4.17(iii)) — 1614934.6 02 September 2016 (02.09.2016) GB of inventorship (Rule 4.17(N)) Published: (71) Applicant: GLAXOSMITHKLINE INTELLECTUAL — PROPERTY (NO.2) LIMITED [GB/GB]; 980 Great West with international search report (Art. 21(3)) Road, Brentford Middlesex TW8 9GS (GB). (72) Inventors: BAXTER, Andrew; GlaxoSmithKline, Gun- nels Wood Road, Stevenage Hertfordshire SG1 2NY = (GB). BROWN, John, Alexander; GlaxoSmithKline, 200 Technology Square, Suite 602, Cambridge, Massachu- setts 02139 (US). HIRST, David; GlaxoSmithKline, Gun- nels Wood Road, Stevenage Hertfordshire SG1 2NY =_ = (GB). HUMPHREYS, Philip; GlaxoSmithKline, Gunnels Wood Road, Stevenage Hertfordshire SG1 2NY (GB). JONES, Katherine, Louise; GlaxoSmithKline, Gunnels Wood Road, Stevenage Hertfordshire SG1 2NY (GB). PA- - TEL, Vipulkumar, Kantibhai; GlaxoSmithKline, Gun- = nels Wood Road, Stevenage Hertfordshire SG1 2NY (GB). Agent: FOWLER, Gavin James; GlaxoSmithKline, Glob- al Patents CN925.1, 980 Great West Road, Brentford Mid- (74) = - = dlesex TW8 9GS (GB). — — Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (81) = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = — 1-1 IN 7r CIN (54) Title: IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY Il DISEASES OR CANCERS 71' 0 0 1-1 R (57) : Compounds of formula (I) and salts thereof: Formula (I) wherein R1, R2, R3 and a are as defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family xi k (:::::) N ''. NH (I) of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in N P1 - )-- - s-.1\"-- therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; R 2 (R3) a and cancers.