Patent RU-2741596-C2 (RU)
Inventor: SY Tszyujtun
IPC: C07D401/14
Filed: 2017-03-10
Granted: 2021-01-27
Abstract: FIELD: pharmaceuticals. 
     SUBSTANCE: invention relates to a compound of general formula (I) or pharmaceutically acceptable salts thereof, where group 
        is selected from the following structure:  , each of R 5   1  and R 5   2  is independently selected from a group consisting of hydrogen; W and Z are each independently selected from N and C-BR 1 ; in the absence of R 1 , B are identical or different and each is independently selected from a group consisting of hydrogen, halogen, C 1 -C 6  alkyl, wherein said C 1 -C 6  alkyl optionally further substituted with one or more groups Q; in the presence of R 1 , B are identical or different and each is independently selected from a group consisting of -O- and -NR 4 -; and R 1  are identical or different and are each independently selected from the group consisting of hydrogen, C 1 -C 6  alkyl, heteroaryl, which is a heteroaromatic system containing 1 to 2 heteroatoms, 5 to 6 ring atoms, where the heteroatom is selected from sulfur and nitrogen, -R u OR x , -R u C(O)OR x , -R u N(R y )(R z ), -C(O)N(R y )(R z ); said alkyl and said heteroaryl is optionally further substituted with one, two or three groups selected from the group consisting of halogen, cyano, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  hydroxyalkoxy, -C(O)NHCH 3 , heterocyclyl, which is a saturated monocyclic hydrocarbon group containing from 4 to 6 ring atoms, 1 or 2 of which can be replaced with oxygen and/or nitrogen, halophenyl, C 3 -C 6  cycloalkyl-tetrazolyl; R 4  is selected from a group consisting of C 1 -C 6  alkyl, or R 4  and R 1  together with the nitrogen atom to which they are attached, form piperazinyl, which is further substituted with one group selected from a group consisting of C 1 -C 6  alkyl; R 2  is hydrogen, G is selected from the group: 
       , which is optionally further substituted with one or two groups selected from a group, consisting of C 1 -C 6  alkyl, amino, -C(O)-CH=CH 2 , C 3 -C 6  cycloalkyl, phenyl and pyridinyl; wherein said C 1 -C 6  alkyl or phenyl can be further substituted with one or three groups selected from a group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, -C(O)OC 2 H 5 ; R 3  is selected from Q group; R u  is selected from a bond or C 1 -C 6  alkylene; R x  is selected from C 1 -C 6  alkyl; R y  and R z  are each independently selected from a group consisting of C 1 -C 6  alkyl; or R y  and R z  together with the nitrogen atom to which they are attached form a heterocyclyl group containing from 6 to 7 ring atoms, which additionally contains 1 heteroatom selected from nitrogen or oxygen, and heterocyclyl group optionally further substituted with one group, selected from the group consisting of C 1 -C 6  alkyl; Q is selected from a group consisting of hydrogen and halogen. Invention also relates to methods of producing said compounds of formula (I). 
     
       
     
     EFFECT: technical result is obtaining novel compounds which can be used in medicine as a tyrosine protein kinase FLT3 inhibitor for preventing and/or treating a malignant growth. 
     12 cl, 11 tbl, 134 ex