Patent AU-2012321089-A1 (AU)
Title: A method of treating mucus hypersecretion
Inventor: O'HEHIR ROBYN
IPC: A61K31/711
Filed: 2012-10-26
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/059876 A1 2 May 2013 (02.05.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K31/711 (2006.01) A61K 39/395 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K31/7105 (2006.01) A61K38/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, ) .a BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, PCT/AU2012/001309 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 26 October 2012 (26.10.2012) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 2011904500 28 October 2011 (28.10.2011) AU (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, PARANTA BIOSCIENCES LIMITED [AU/AU]; Cl- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, MPR Group Pty Ltd, Level 19, HWT Tower, 40 City Road, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Southbank, Victoria 3006 (AU). EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors; and MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (71) Applicants (for US only): O'HEHIR, Robyn [AU/AU]; TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 120 Gatehouse Street, Parkville, Victoria 3052 (AU). ML, MR, NE, SN, TD, TG). HARDY, Charles [AU/AU]; 44 Laura Street, Brunswick, Published: Victoria 3056 (AU). DE KRETSER, David [AU/AU]; 1 - with international search report (Art. 21(3)) Leura Street, Surrey Hills, Victoria 3127 (AU). (74) Agents: OBRANOVICH, Tania, Daniela et al.; Davies Collison Cave, 1 Nicholson Street, Melbourne, Victoria 3000 (AU). II) O (54) Title: A METHOD OF TREATING MUCUS HYPERSECRETION (57) Abstract: The present invention relates generally to a method of reducing unwanted airway tissue mucus secretion in a mammal and to agents useful for same. More particularly, the present invention relates to a method of reducing airway tissue mucus hyperse f4 cretion in a mammal by downregulating the functional level of activin or upregulating the functional level of follistatin. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by airway tissue mucus dysfunction, such as overproduction of mucus or decreased mucus clearance, and where a reduction in mucus secretion levels would thereby alleviate the condition.