baber/WOPTO huggingface dataset:
Patent PT-1255752-E (PT)
Title: Pyrrole substituted 2-indolinone protein kinase inhibitors
Inventor: TANG CHO PENG
IPC: A61P37/06
Filed: 2001-02-15
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Patent PT-1236728-E (PT)
Inventor: SUMIHIRO NOMURA
IPC: C07D471/12
Filed: 1997-10-27
Abstract: A process for preparing an S type 4-substituted hydroxypyrano-indolidine compound of the formula (VII) :   
wherein R o  is a residue of a nitrogen-containing fused heterocyclic carboxylic acid having an absolute configuration of "R" which is obtained by removing hydroxy group from the carboxyl group of said carboxylic acid (in which the nitrogen atom contained in the residue is protected), is described.  The process involves reduction, alkanoylation, nitrosation, rearrangement and intramolecular cyclization reactions.
Patent PT-1323643-E (PT)
Inventor: WANG SOO CHANG
IPC: B65D79/02
Filed: 2002-12-13
Abstract: Disclosed is a vacuum valve including a lid (20), a depression (24) defined on the lid, a boss (25) formed on the lid at a bottom of the depression, a rotary cover (32) rotatably arranged in the depression, and a closure member detachably coupled to the rotary cover. The vacuum valve comprises a through-hole (26) defined at a center portion of the closure member; a vacuum maintaining member (50) accommodated in the closure member and having an airtightening flange part and a semi-spherical head part, the airtightening flange (51) part being brought into close contact with a portion of the rotary cover, and the semi-spherical head part projecting upward from the airtightening flange part in a rounded manner such that, as the lid of a vacuum container is repeatedly pressed and released, air existing in a container body is discharged to the outside and vacuumization is effected in the vacuum container; and an exposure bar extending upward from the semi-spherical head part by a predetermined length such that the exposure bar can be moved upward and downward through the through-hole of the closure member depending upon a vacuumization degree to allow a user to confirm a vacuumized state of the vacuum container with the naked eye. <IMAGE>
Patent PT-1231122-E (PT)
Title: Brake booster with controlled position
Inventor: LACROIX STEPHANE
IPC: B60T13/52
Filed: 2002-02-07
Abstract: Braking assistance servomotor including braking control rod (1), a brake assistance control device (2) actuated by the control rod and control rod position Foucalt current sensor (4,6). Sensor is mounted on brake assistance device (2). Has an electric control circuit (4) and excitation winding (5). fixed to control rod, also an assembly (10,15) comprising aluminum parts including cylindrical elements enveloping a braking control rod (1). The assembly includes two different section cylinders partially overlapping (16) each other.. One of the cylindrical pats is fixed to a base part (8) of the rod and the other is fixed to a high part (9) of the rod. An AC source feeds the excitation winding. Braking system including a brake assistance servomotor having a master cylinder receiving assistance from the servomotor and connected to brakes at wheel level. A computer generates control commands to at least an hydraulic pump. The computer receives control rod (1) position data from the sensor (4,6). For an axial position determined from the control rod the computer sends a command to the pump to send a supplementary quantity of hydraulic fluid to the brakes.
Patent PT-1360353-E (PT)
Title: Reinforced thermostable hybrid yarn
Inventor: GUEVEL JEAN
IPC: D02G3/04
Filed: 2002-02-15
Abstract: The inventive yarn comprises at least one strand ( 2 ) having a reinforcing core made of high-modulus and high-resistance staple-fiber yarn, which is made from organic or inorganic material, and a sheath ( 4 ) of long or short, low-modulus standard fibers. The other strands ( 5 ) are made from long or short, low-modulus standard fibers and are arranged so as to protect the sheath of the strand(s) having a reinforcing core.
Patent PT-1409945-E (PT)
Inventor: MAUCH ERNST
IPC: F41A17/06
Filed: 2002-07-25
Abstract: Firearms protected from unauthorized use are disclosed. A disclosed firearm comprises a housing having a handle; a safety located in the housing to selectively prevent firing; and a module removably attachable to the handle and containing an electronic identification device to identify an authorized user. The electronic identification device controls the safety to prevent firing by unauthorized persons and to permit firing by the authorized user.
Patent PT-1476192-E (PT)
Title: Methods and compositions for treating hyperproliferative conditions
Inventor: STILES CHARLES DEAN
IPC: A61K31/506
Filed: 2003-02-14
Abstract: The present invention relates to a combination which comprises a an inhibitor of a tissue non-specific growth factor receptor and b an inhibitor of a tissue specific growth factor receptor for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of phyperproliferative conditions, such as in particular cancer, in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating hyperproliferative conditions, such as especially cancer, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.
Patent PT-1486785-E (PT)
Title: Test agents for evaluating pharmacological effect of drug, and method and reagents for screening drug having excellent administration effect and/or little side effect from among drugs comprising enzymes, enzyme inhibitors or receptor ligands and/or p
Inventor: KOHNO TADASHI
IPC: A61K51/12
Filed: 2003-02-20
Abstract: A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a prodrug of the pharmaceutical agent; and a method of screening pharmaceutical agents each comprising an enzyme, an enzyme inhibitor or a receptor ligand and/or prodrugs of the pharmaceutical agents for one or ones having high medicative efficacy and/or a small side effect are provided. The diagnostic reagent and the reagent used in the method comprise: (a) a compound which serves as a substrate for the enzyme contained in the medicine or the pharmaceutical agent to be evaluated or for an enzyme generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; (b) a compound which serves as a substrate for a different enzyme capable of exhibiting an alteration in activity by coupling to the effect of the enzyme in (a), or a pharmaceutically acceptable salt thereof; (c) a compound which serves as a substrate for an enzyme which is directly inhibited by the enzyme inhibitor contained in the medicine or the pharmaceutical agent to be evaluated or by an enzyme inhibitor generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; (d) a compound which serves as a substrate for an enzyme capable of exhibiting an alteration in activity by coupling to the effect of the enzyme inhibitor in (c), or a pharmaceutically acceptable salt thereof; (e) a compound which serves as a substrate for an enzyme capable of exhibiting an alteration in activity by the binding between a receptor and the receptor ligand contained in the medicine or the pharmaceutical agent to be evaluated or a receptor ligand generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; or (f) a labeled form of any one of the substances (a) to (e). <IMAGE>
Patent PT-1539166-E (PT)
Title: Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
Inventor: POPE LAURA E
IPC: A61K31/4745
Filed: 2003-07-17
Abstract: Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.
Patent PT-1603544-E (PT)
Title: De
Inventor: DEVANE JOHN
IPC: A61K45/06
Filed: 2004-03-12
Abstract: The present invention is directed to methods and formulations for reducing, preventing, and/or managing abnormal increases in gastrointestinal motility, and intestinal conditions that cause the same. Methods of using N-2,2,3-tetramethylbicyclo-[2.1.1]heptan-2-amine and formulations comprising N-2,2,3-tetramethylbicyclo-[2.1.1]heptan-2-amine are included.
Patent PT-1607402-E (PT)
Title: Method for the diagnosis of tumour
Inventor: ASHKENAZI AVI J
IPC: C12N15/13
Filed: 2000-02-11
Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment.  The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Patent PT-1947202-E (PT)
Title: Filter powder recycling process
Inventor: VEYE CARLOS RUIZ DE
IPC: C22B7/02
Filed: 2006-12-18
Abstract: The present invention relates to a process of treating filter powders (3) of the type produced in aluminium recycling processes in a recycling system for recycling the metal (1) of saline slag recycling (2), comprising at least a pyrolysis step (31) in which the filter powders (30) enter a rotating auger where they are heated to a temperature of not less than 500°C and not more than 600°C; and in which the organic and toxic substances breakdown in this heating and part of the carbon and other combustibles burn in the controlled presence of air, this air being mixed with the powder by the movement of the rotating auger; in which organic materials are oxidized due to the oxygen provided; and in which the solid result of the pyrolysis step (31) is added to the general saline slag recycling process (2).
Patent PT-2021984-E (PT)
Title: A security device meant to be connected to a processing unit for audio/video signal and method using such a device
Inventor: OSEN KARL
IPC: G06K19/07
Filed: 2007-05-31
Abstract: The device (10) has a clock frequency detector (13) connected to a clock input of International organization for standardization (ISO) 7816 type contacts (1-6). The detector has a discrimination unit that discriminates an input frequency based on high and low frequency ranges, where one of the frequency ranges activates a universal serial bus (USB) function. A safety module has a frequency divider (12) and a frequency multiplier for producing a frequency from higher and lower frequencies, respectively. An independent claim is also included for a method of processing an audio/video signal.
Patent PT-1023050-E (PT)
Title: Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
Inventor: MAGDASSI SHLOMO
IPC: A61P35/00
Filed: 1998-06-26
Abstract: In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.
Patent PT-525384-E (PT)
Inventor: DIETRICH GABRIELE ELFRIEDE
IPC: C12N15/87
Filed: 1992-06-24
Abstract: The present invention relates to monocot genes encoding a mutant AHAS enzyme that is specifically resistant to imidazolinone herbicides. Exemplary of these genes are corn DNA sequences which encode an amino acid substitution at position 621 of the wild-type AHAS enzyme. The mutant gene can be used to transform other plants to herbicide resistance; in this regard, the invention also provides host cells and vectors containing the gene, which cells and vectors are useful in the transformation process.
Patent PT-617028-E (PT)
Inventor: COSSEMENT ERIC
IPC: A61P43/00
Filed: 1994-03-09
Abstract: The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives (V) or their salts in medicines for the treatment of allergies, is new.  The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives of formula (V) or their salts, in medicines for the treatment of allergies, is new:  R  =  H, (3-methylphenyl)methyl, (4-tert-butylphenyl)methyl, 2-(2-hydroxyethoxy)ethyl, 2-(2-(hydroxyethoxy)ethoxy)ethyl, 2-(carbamoylethoxy)ethyl, 2-(methoxycarbonylmethoxy)ethyl or 2-(carboxymethoxy)ethyl.
Patent PT-697825-E (PT)
Inventor: SKAJA JOSEPH A
IPC: A43B13/40
Filed: 1994-05-03
Abstract: A high polymer resin material is configured into a shoe sole component having a plurality of inwardly extending indentations in one or both of the top and bottom members of the component. The indentations extend into the interval between the members and adjacent to the opposite member to provide support members for the sole component. The sole component can be constructed by molding upper and lower sole component halves wherein the molds are configured to provide indentations in the top and bottom members. The upper and lower sole component halves are then joined to complete the sole component. <IMAGE>
Patent PT-703757-E (PT)
Inventor: MICHELSON GARY KARLIN
IPC: A61B17/16
Filed: 1994-06-09
Abstract: A spinal distractor for use in spinal surgery is described for temporarily positioning two adjacent vertebral bodies in selected relationship to restore the height of the disc space therebetween prior to inserting an implant into the distracted disc space.The spinal distractor comprises a body, and a disc penetrating extension extending from the body and configured to distract the adjacent vertebral bodies upon insertion into the disc space. The disc penetrating extension is adapted to bear against adjacent endplates of the two adjacent vertebral bodies, and has a first portion for bearing against one of the adjacent endplates and a second portion for bearing against the other of the adjacent endplates. The disc penetrating extension has a height no greater than the restored height of the disc space.
Patent PT-848076-E (PT)
Inventor: GUESDON PHILIPPE
IPC: C23C2/02
Filed: 1997-12-10
Abstract: Prior to top coating steel sheet by dipping in a bath of molten zinc or aluminium alloy, the sheet is cleaned, annealed and given a first coating of at least one oxide 0.01-0.1 microns thick and a second coating of an alloy containing at least 20% iron. Also claimed are steel sheets respectively dip-coated with Fe-Zn alloy or Al based alloy on top of the first and second coatings.
Patent PT-909449-E (PT)
Inventor: MARTINSSON HANS-BERTIL
IPC: H01B3/44
Filed: 1997-07-01
Abstract: PCT No. PCT/FI97/00428 Sec. 371 Date Feb. 23, 1999 Sec. 102(e) Date Feb. 23, 1999 PCT Filed Jul. 1, 1997 PCT Pub. No. WO98/01870 PCT Pub. Date Jan. 15, 1998The invention relates to a coaxial high-frequency cable including an inner conductor, a dielectric material formed about the inner conductor, and an outer conductor formed about the dielectric material. According to the invention, the dielectric material is made from an expanded polymer blend compounded from two a-olefin polymers of different densities, whereby the polymer of the higher density forms the matrix of the polymer blend.
Patent PT-855979-E (PT)
Inventor: KLEIN LOTHAR
IPC: B62D33/04
Filed: 1997-08-13
Abstract: PCT No. PCT/EP97/04390 Sec. 371 Date Aug. 5, 1998 Sec. 102(e) Date Aug. 5, 1998 PCT Filed Aug. 13, 1997 PCT Pub. No. WO98/07605 PCT Pub. Date Feb. 26, 1998The invention relates to a modular unit consisting of two building components having joint surfaces arranged in pairs to be fastened with rivets. In order to ensure perfect meeting of the pairs of joint surfaces, there is a pair of bearing surfaces designed in such a way that, upon exerting a supporting force thereon, a force component is generated through the assembling joints.
Patent PT-973794-E (PT)
Inventor: TESSIER-LAVIGNE MARC
IPC: C07K16/28
Filed: 1998-02-19
Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Patent PT-1119456-E (PT)
Inventor: WILFORD-BROWN JACQUIN HILARY
IPC: B32B7/04
Filed: 1999-10-08
Abstract: A composite material comprises a first layer and a second layer, said layers being bonded together, wherein said first layer comprises 40 - 95 % by weight of an acrylic polymer formed from a monomer comprising 60 - 100 % methyl methacrylate and 0 - 40 % of a vinylic comonomer and 5 - 60 % of a copolymer wherein at least 10 % of the monomer residues are (optionally substituted) styrene and said second layer comprises a thermoplastic polymer. The material is particularly useful for forming sanitary articles, e.g. shower trays by thermoforming. A preferred second layer material is HIPS.
Patent IE-810005-L (IE)
Title: Mould forming process
IPC: B22C1/22
Filed: 1981-01-05
Abstract: To form a shaped foundry core or mould, a binder material comprising an ethylenically unsaturated monomer or polymer is distributed on a foundry aggregate, the aggregate is shaped into the desired foundry article, and the binding material is then polymerised by means of a free radical initiator comprising a peroxide and catalytic agent. The binding material is preferably a solution of an ethylenically unsaturated polymer in a solvent of unsaturated monomeric compound or compounds, in which vinyl or acrylic unsaturation is present. This binder is suitable as a foundry binder of the cold box type wherein a room temperature, rapid gas cure is utilized. The gas, preferably sulfur dioxide, serves as the catalytic agent of the free radical initiator. Alternatively the catalytic agent may be heat. The binder collapses readily after casting of aluminium and other lightweight metals to provide complete shakeout of the core with minimum application of external energy.
[GB2066714A]
Patent IE-33982-L (IE)
Title: Epoxyethylphosphonic acid derivatives
IPC: C09D7/00
Filed: 1970-01-06
Abstract: 1282671 Antiseptics MERCK & CO Inc 12 Jan 1970 [17 Jan 1969] 1406/70 Heading A5B [Also in Division C2] A pharmaceutical or antiseptic composition comprises a compound of formula where D is -O- or -NR 4 -, R 4 is optionally substituted hydrocarbyl or hydrogen, and W is optionally substituted hydrocarbyl, optionally containing one or more heteroatoms, Z, is -OR, -SR, -NR 1 R 2 , -OM, -SM or halogen, M is a cation, R is hydrogen, acyl or optionally substituted hydrocarbyl, R 1 and R 2 are hydrogen, optionally substituted hydrocarbyl or acyl or alkoxy, or -NR 1 R 2 is the residue of a cyclic secondary amine, and R 3 is C 1-6 alkyl, benzyl or a metal cation, together with other biologically active ingredients, such as erythromycin, lincomycin, penicillins, streptomycin, novobiocin, tylosin, genta mycin, neomycin, colistin, kanamycin, oleandomycin, triacetyloleandomycin, chloramphenicol, tetracyclines, sulphonamides and spiramycin.
[GB1282671A]
Patent IE-870133-L (IE)
Title: Potable spirit production
IPC: C07C29/86
Filed: 1987-01-20
Abstract: A method and apparatus for removing water from a liquid mixture of water and ethanol contacts it with liquid carbon dioxide so that the ethanol is preferentially transferred into solution, dries the solution using an adsorbent, and then recovers dry ethanol by distilling off the carbon dioxide. This process is particularly energy efficient especially when it includes a fermentation process to generate the ethanol and uses the carbon dioxide generated during the fermentation as the source of liquid carbon dioxide. In this case the method and apparatus provide an additional product of dry carbon dioxide.
Patent IE-890139-L (IE)
Title: Stand-up Bag
IPC: B65D33/38
Filed: 1989-01-18
Abstract: A bag for containing liquid products, for example, is made of a heat-weldable sheet material. The sheet material may suitably be a compound sheet material which provides a rear face, a front face and an insert bottom. Disposed at an upper portion of the front or rear face is a threaded closure comprising a screw-threaded pipe socket and a screw cap. The pipe socket penetrates one face of the bag and is bonded to the interior surface of the bag with the aid of a welding flange having a larger diameter. The welding flange has a chamfered outer rim cooperating with the sheet material to form a V-shaped circumferential groove which is at least partially filled with the molten plastic material of the sheet during the welding operation. The threaded closure permits the bag to be repeatedly opened and closed for piecemeal dispensing its contents.
Patent IE-850229-L (IE)
Title: Suspension of sodium cromoglycate in oily non-aqueous¹vehicle
IPC: A61K31/365
Filed: 1985-01-31
Abstract: There is described a suspension of finely divided sodium cromoglycate in an oily non-aqueous vehicle. The oily vehicle is preferably structured and may also contain another active ingredient, e. g. an antibiotic. The compositions are useful in the treatment of conditions of the eye or nose in which conditions allergy or immune reactions play a contributory part.
[EP0153003A2]