baber/WOPTO huggingface dataset:
Patent CA-3098137-A1 (CA)
Inventor: LU BAISONG
IPC: C12N15/86
Filed: 2019-05-01
Abstract: Provided are compositions, systems, and methods useful for effecting gene editing in eukaryotic cells. Compositions include plasmids that encode one or more viral fusion proteins in which one or more viral proteins are fused with an aptamer-binding protein. Compositions also include plasmids that encode a non-viral nucleic acid sequence, wherein the non-viral nucleic acid sequence encodes a CRISPR system component. In some instances, the non-viral nucleic acid sequence also includes an aptamer sequence. The plasmids can be used to generate viral particles, including lentivirus-like particles that contain a viral fusion protein and a non-viral RNA sequence. Systems of producing such viral particles are provided. Also provided are methods of using the viral particles of the disclosure to effect gene editing in eukaryotic cells.
Patent CA-3099236-A1 (CA)
Title: Method of preparing a surface for diffusion bonding and method of diffusion bonding
Inventor: FUESTING TIMOTHY
IPC: B23K1/20
Filed: 2020-11-13
Abstract: ABSTRACT A method of preparing a surface for diffusion bonding comprises contacting a binder material with a discontinuous surface comprising surface regions separated by gaps. The binder material is selectively deposited onto the surface regions and has a sufficient viscosity to form a self-supporting layer without flowing into the gaps. The self-supporting layer of binder material comprises a mass density in a range from about 0.001 g/in2to about 0.050 g/in2. A braze powder is distributed over the self-supporting layer of binder material, and a predetermined amount of the braze powder is attached to the binder material. The discontinuous surface is then heated to remove the binder material and adhere the braze powder to the discontinuous surface. Thus, a prewet surface with a braze deposit thereon is formed. Date Recue/Date Received 2020-11-13
Patent CA-3101822-A1 (CA)
Title: Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof
Inventor: CHEN LI
IPC: A61P3/04
Filed: 2019-05-28
Abstract: The present invention relates to a pharmaceutical combination. The pharmaceutical combination comprises a glucose kinase activator or a pharmaceutical salt of same, an isotope marker of same, a crystal form, hydrate, solvate, diastereomer or enantiomer form of same, and a PPAR receptor activator. The present invention further relates to a pharmaceutical composition, a fixed-dose compound preparation, and a preparation method for and uses of the pharmaceutical composition and of the fixed dose compound preparation.
Patent CA-3110534-A1 (CA)
Inventor: BUDZIAK CHESTER J
IPC: E04F11/18
Filed: 2013-07-24
Abstract: ABSTRACT A safety assembly is provided for placement on a roof of a building, near an edge of the roof, having a ladder restraint, an upstanding barrier, and a counterweight.  The ladder restraint has an opening to receive a ladder that provides access to the roof. The opening is sized to restrict left and right sideways movement of the ladder. The upstanding barrier extends on left and right sides of the ladder restraint to block falls by a user. The counterweight is interconnected to both the ladder restraint and the upstanding barrier, and is disposed to prevent forward tipping of the upstanding barrier by the user, and to prevent sideways tipping of the ladder during use, when the safety assembly is placed on the roof and the ladder is received through the ladder restraint. The safety assembly may be assembled on the roof without penetrating the roof's waterproofing membrane. Date Recue/Date Received 2021-02-25
Patent CA-3112144-A1 (CA)
Title: System and method of releasably securing wedge in a cap
Inventor: NOBLE ANGUS
IPC: E06B3/54
Filed: 2021-03-18
Abstract: Open-topped channels/troughs are often used as a footing in which glass panels may be placed and secured substantially vertically. A tapered wedge may be forced into the gap around the panel. As gradually wider portions of the wedge are forced into the gap, the panel is gripped ever tighter. However, it is often difficult to remove panels secured in this manner. The present invention provides a wedge support which can be separated into two portions by the insertion of a tool into a tool socket. In this way, if a wedge is used with the wedge support, the wedge support may be removed with the tool thereby permitting easy removal of the wedge.
Patent CA-3113728-A1 (CA)
Inventor: GIBSON PAUL ANDREW CHRISTOPHER
IPC: A61K39/395
Filed: 2019-09-19
Abstract: A method of adapting an auto injector configured to actuate a prefilled syringe, the auto injector having a biasing member having a spring constant, the prefilled syringe being filled with a volume of therapeutic fluid, the prefilled syringe including a barrel, stopper, and a needle, the stopper having a path of travel, the biasing member arranged to move the stopper along the path of travel. An auto injector having an injection spring adapted to an aged prefilled syringe.
Patent CA-3114121-A1 (CA)
Title: Memory card, memory card adapter, and terminal device
Inventor: YANG JIANGTAO
IPC: H04M1/02
Filed: 2018-10-16
Abstract: Provided in the present application are a SIM, a memory card, a memory card adapter, and a terminal. The terminal comprises: a card base, a SIM module, a memory card module, a switch, a detection circuit, and a control circuit; the card base is used for arranging the SIM or memory card, and the card base comprises a first interface, the first interface being connected to the SIM or the memory card by means of the switch; the first interface is connected to a first end of the switch; the SIM module is connected to a second end of the switch; the memory card module is connected to a third end of the switch; the detection circuit is used for detecting that a card arranged in the terminal is a SIM or a memory card; and, on the basis of the detection result of the detection circuit, the control circuit controls the first end of the switch to connect the second end of the switch or controls the first end of the switch to connect the third end of the switch. Thus, the card base of the terminal can be used for arranging a SIM card and can also be used for arranging a memory card, thereby improving the rate of utilisation of the space in the terminal.
Patent CA-3114546-A1 (CA)
Title: Method of controlling a well
Inventor: ROSS SHAUN COMPTON
IPC: E21B29/06
Filed: 2018-09-18
Abstract: A method of controlling a well in a geological structure, the well comprising: a first casing string (12a), and a second casing string (12b) at least partially inside the first casing string thus defining a first inter-casing annulus therebetween. A primary fluid flow control device (16a), such as a wirelessly controllable valve, is provided in the second casing string (12b) to provide fluid communication between the first inter-casing annulus(14a) and a bore (14b) of the second casing string (12b). In the event of well "blow-out", a relief well (40) may be drilled and a fluid communication path formed between the relief well and the first casing string of the well rather than extend to lower and/or narrower sections of casing. A kill fluid can then be introduced via the relief well (40) and the primary fluid flow control device (16a) used to direct fluid to the second casing bore(14b). Further casing strings (12c) may be part of the well, and include corresponding flow control devices (16b), allowing the kill fluid to cascade down the well to control it. Accordingly, the time taken to drill a relief well to a shallower depth than is conventional can reduce the time and cost to control the well and can mitigate environmental impact of hydrocarbon loss caused by the blow-out.
Patent CA-3115431-A1 (CA)
Inventor: CHAN PUI-KWONG
IPC: C07J63/00
Filed: 2011-07-15
Abstract: This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases.
Patent CA-3117751-A1 (CA)
Inventor: SKOGLUND ESKIL
IPC: G01N29/26
Filed: 2019-10-25
Abstract: A scanning system for imaging an object, the scanning system comprising: a scanning apparatus configured to transmit ultrasound signals towards an object and to receive ultrasound signals reflected from an object whereby data pertaining to an internal structure of an object can be obtained; a location sensor for sensing a location of the scanning apparatus; and an instruction unit arranged to provide instructions to a user of the scanning system in dependence on the sensed location.
Patent CA-3118138-A1 (CA)
Title: Rice bran extract compositions, methods of making and using same
Inventor: SOMA PAVAN KUMAR
IPC: A23L33/105
Filed: 2019-11-01
Abstract: Aspects of the present disclosure relate to compositions comprising rice bran extract, method of making rice bran extract and method of using same.
Patent CA-3123383-A1 (CA)
Title: Fitting for a rain gutter downpipe
Inventor: FOX JESSE
IPC: E04D13/08
Filed: 2021-06-28
Abstract: A downpipe fitting for coupling between top and bottom ends of a downpipe. The downpipe fitting includes two parts connected together and rotatable relative to one another about a longitudinal axis thereof. The first part has an inlet, sized and shaped to couple with an outlet of a first section of the downpipe, above the downpipe fitting. The second part has an outlet which is sized and shaped to couple with an inlet of a second section of the downpipe, below the downpipe fitting.  The inlet and outlet of the fitting define a flow path for rainwater therethrough.  Rotation of the second section of downpipe below the downpipe fitting, about the longitudinal axis, is decoupled from the first section of downpipe above the downpipe fitting.
Patent CA-3125698-A1 (CA)
Title: Tracking tainted connection agents
Inventor: SINGLETON LEO C
IPC: G06F21/33
Filed: 2020-01-02
Abstract: Methods and systems for tracking tainted connection agents, such as without a trusted central authority, are described herein. During a server outage, a client device may verify that a connection agent is untainted based on a public-key encryption or certificate-based system. If the connection agent is untainted, a server may sign a public key or certificate associated with the connection agent. The server may provide, to the client device, a lease, a public key associated with the server. The connection agent may sign data generated by the client device. The client device may verify a signature of the signed public key, such as based on the public key associated with the server. The client device may verify a signature of the signed data, such as based on the verified public key associated with the connection agent.
Patent CA-3126645-A1 (CA)
Title: Method of manufacturing a lens with an embedded foil
Inventor: KORNER LUTZ
IPC: B29D11/00
Filed: 2021-08-03
Abstract: A lens with an embedded foil is produced, comprising the steps of providing a first mold and a second mold, providing a functional foil, positioning and attaching (10) the functional foil on the first mold, aligning (20) the second mold relatively to the first mold, sealing (30) the mold cavity between the first mold and the second mold, and filling (50) a curable monomer mixture into the mold cavity, wherein either the molds are heated before the alignment step or the molds are heated after the sealing step and the following filling step (50) is conducted with a heated monomer, or the heating of the molds follows the filling step (50) of the UV curable monomer, followed by a UV curing step (60) of the heated UV curable monomer mixture within the heated mold cavity.
Patent CA-3126819-A1 (CA)
Title: Nuclear reactor fuel assemblies and process for production
Inventor: SHARGOTS SCOTT J
IPC: G21C3/33
Filed: 2020-01-10
Abstract: A nuclear fuel assembly for a nuclear reactor core including at least one fuel cartridge having a lattice structure including an outer wall defining an interior volume, at least one flow channel extending through the interior volume of the lattice structure, at least one lattice site disposed in the interior of the lattice structure; and at least one fuel compact disposed within a corresponding one of the at least one lattice site. A cross-sectional shape of the at least one fuel compact is the same as a cross-sectional shape of the corresponding one of the at least one lattice site.
Patent CA-3126972-A1 (CA)
Inventor: STEGEMAN JOHN T
IPC: F21S8/08
Filed: 2021-08-05
Abstract: A multi-panel municipal luminaire comprising a plurality of independently operable sources of illumination, such as but not limited panels of light-emitting diodes (LEDs), and systems and methods for independently operating subsets of the panels within a single luminaire to provide multi-zone illumination. The control signals may be transmitted via a dimming receptacle from a luminaire control device, which may be programmed to operate each subset of panels, or which may receive instructions from a remote command center or operate each set of panels in real-time in response to local events detected by a sensor, such but not limited to as an approaching or departing vehicle or pedestrian, or a weather event.
Patent CA-3130812-A1 (CA)
Inventor: WOZNIAK MARK
IPC: C11D17/06
Filed: 2017-10-18
Abstract: Ambient moisture-activatable surface treatment powders containing persalt, positively charged phase transfer agent and alkaline pH buffering may be activatable without the addition of liquid. Some ambient rnoisture-activatable surface treatment powders are substantially free of bl each acti vators and/or chl orine. Methods of use of ambi ent moi sture acti vatabl e powders incl ude applying them to the surfaces to be treated.
Patent CA-3136311-A1 (CA)
Title: Procede d'evaluation de performances de batterie et dispositif d'evaluation de performances de batterie
Inventor: MUNAKATA ICHIRO
IPC: G01R31/374
Filed: 2020-12-16
Abstract: La présente invention concerne un dispositif et similaire permettant d'améliorer la précision d'évaluation de performances de batterie d'une batterie secondaire. Sur la base du résultat de mesure d'une impédance complexe Z d'une première batterie secondaire 221, des valeurs de paramètres d'un modèle de batterie secondaire sont identifiées. Dans le modèle de batterie secondaire, l'impédance de la résistance interne de la première batterie secondaire 221 est représentée par des fonctions de transfert indiquant respectivement un système d'IIR et un système de FIR. En outre, sur la base du résultat d'une comparaison entre une caractéristique de réponse en tension V(t) émise par une seconde batterie secondaire 222 lorsqu'un courant d'impulsion I(t) est entré dans une batterie secondaire 220 servant de seconde batterie secondaire 222 et une caractéristique de réponse en tension modèle Vmodèle lorsque le courant d'impulsion est entré dans le modèle de batterie secondaire dont les valeurs de paramètres ont été identifiées, les performances de la seconde batterie secondaire 222 sont évaluées.
Patent CA-3138675-A1 (CA)
Title: Dry double-sided material for adhesion of wet tissues and devices
Inventor: ZHAO XUANHE
IPC: A61L31/04
Filed: 2020-04-11
Abstract: Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.
Patent CA-3139089-A1 (CA)
Title: Flexible tubular spring structure, and scoring balloon catheter equipped therewith
Inventor: SHULZE JOHN E
IPC: A61M25/09
Filed: 2020-05-07
Abstract: A resiliently expandable elongate tubular spring structure, e.g., corresponding to a metal mesh type structure, mountable or mounted to a scoring balloon catheter includes multiple ring structures that are longitudinally separated from each other along portions of a balloon working region, and which are resiliently radially expandable in response to outwardly directed balloon expansion forces. Pairwise adjacent ring structures are structurally coupled and separated from each other by a scoring link, e.g., a single scoring link, configured as a traumatic structure with respect to vascular tissue, e.g., by way of having a square, trapezoidal, or raised blade tissue scoring / cutting profile. Each ring structure includes a pair of radially resiliently radially expandable annular springs, longitudinally separated from each other by a plurality of spacing elements, e.g., wire links, and which are atraumatic or substantially atraumatic structures relative to the scoring link with respect to tissue.
Patent CA-3140749-A1 (CA)
Inventor: VILLEMOES LARS
IPC: G10L19/04
Filed: 2014-01-07
Abstract: The present document describes methods and systems which improve the quality of audio source coding employing prediction in the subband domain of a critically sampled filterbank. The methods and systems may make use of a compact description of subband predictors, wherein the description is based on signal models.  Alternatively or in addition, the methods and systems may make use of an efficient implementation of predictors directly in the subband domain. Alternatively or in addition, the methods and systems may make use of cross subband predictor terms, as described in the present document, to allow for a reduction of alias artifacts.
Patent CA-3142181-A1 (CA)
Title: Ice-generating system, method and apparatus
Inventor: STANDAAR KOEN
IPC: A47J31/40
Filed: 2020-05-11
Abstract: An ice-generating system (311), method and apparatus for preparing an ice-containing tea or coffee beverage, comprising a product conduit (330) formed as a loop for circulating there through a beverage liquor, a product pump (390) for pumping the beverage liquor around the loop of the product conduit and a cooling conduit (331) for flowing there through a coolant. The cooling conduit is arranged in proximity with the product conduit to permit heat exchange between the coolant in the cooling conduit and the beverage liquor in the product conduit to cool the beverage liquor to thereby form a plurality of ice crystals within the beverage liquor. The product conduit comprises an outlet (393) for discharging the beverage liquor containing the plurality of ice crystals from the product conduit towards a beverage dispensing outlet (303) and two or more beverage liquor inlets (394, 395) for inputting beverage liquor into the product conduit.
Patent CA-3144946-A1 (CA)
Title: Hollow spring and method of manufacturing the same
Inventor: SAYAMA HIRONOBU
IPC: F16F1/02
Filed: 2020-05-15
Abstract: Included are a step for providing a tubular member (10) for use as a hollow spring, and a step for applying compressive force from the circumferential direction to at least a part of an outer surface of the tubular member (10) and imparting compressive residual stress to at least a part of an inner surface of the steel tube, and by imparting the compressive residual stress to the inner surface of the tubular member (10), the fatigue life of the tubular member (10) is improved. The step in which force is applied to the outer surface of the tubular member (10) includes a step for pressing the tubular member (10) with an indenter (1). The indenter (1) has a pressing surface (1a) of a shape that is capable of applying compressive force from the circumferential direction to at least a part of the outer surface of the tubular member (10).
Patent CA-3146052-A1 (CA)
Title: Mek inhibitor for treatment of stroke
Inventor: EDVINSSON LARS
IPC: A61P25/28
Filed: 2020-07-28
Abstract: The present invention relates to a MEK inhibitor and compositions thereof, for use in the treatment of stroke, in particular treatment of subarachnoid haemorrhage (SAH)
Patent CA-3146295-A1 (CA)
Inventor: DURAND FABIEN
IPC: F25B1/10
Filed: 2020-07-08
Abstract: Disclosed is a low-temperature refrigeration device which is arranged in a frame (100) and comprises a working circuit (10) that forms a loop and contains a working fluid, the working circuit (10) forming a cycle comprising, connected in series: a compression mechanism (2, 3), a cooling mechanism (4, 5, 6), an expansion mechanism (7) and a heating mechanism (6, 8), wherein the mechanisms for cooling and heating the working fluid comprise a common heat exchanger (6) in which the working fluid flows in opposite directions in two separate transit portions of the working circuit (10), the device (1) further comprising a refrigeration heat exchanger (8) for extracting heat from at least one member (125) by exchanging heat with the working fluid flowing in the working circuit (10), the compression mechanism (2, 3) comprising two separate compressors (2, 3), the mechanism (4, 5, 6) for cooling the working fluid comprising two cooling heat exchangers (4, 5) which are arranged respectively at the outlet of the two compressors (2, 3) and ensure heat exchange between the working fluid and a cooling fluid, wherein the frame (100) extends in a longitudinal direction (A) and comprises a lower base (101) intended to be mounted on a support, the cooling heat exchangers (4, 5) are located in the frame (100) about the common heat exchanger (6), i.e. the cooling heat exchangers (4, 5) are not located below the common heat exchanger (6) between the common heat exchanger (6) and the lower base (101) of the frame (100).
Patent CA-3150827-A1 (CA)
Title: Oral pharmaceutical composition
Inventor: YOSHIMURA MOTOYASU
IPC: A61K47/12
Filed: 2020-08-13
Abstract: Provided is a means that can prevent the initial excessive release of an active ingredient and sustainedly release said active ingredient in a therapeutically effective amount over a long period of time.
Patent CA-3152417-A1 (CA)
Inventor: MEREDITH JAMES CARSON III
IPC: C08L5/08
Filed: 2020-09-30
Abstract: L'invention concerne des films et des matériaux comprenant du poly(alkylène glycol)-chitosane et/ou de la chitine-poly(acide glucuronique) et du chitosane et/ou de la chitine-poly(acide glucuronique). L'invention concerne également des procédés de fabrication de tels films, consistant en particulier à réticuler thermiquement du poly(acide glucuronique) avec du chitosane.
Patent CA-3155670-A1 (CA)
Title: Sweetener blends with improved taste
Inventor: HIGIRO JUVENAL
IPC: A23L2/60
Filed: 2020-09-28
Abstract: Beverage syrups and finished beverages comprising a sweetener blend of a steviol glycoside mixture comprising rebaudioside M and certain synthetic sweeteners in particular amounts that provide improved sensory profiles are described herein. Also provided are methods of preparing beverage syrups and finished beverages.
Patent CA-3157763-A1 (CA)
Title: Novel pain relief composition method of use
Inventor: CHENG CHEN
IPC: A61K35/20
Filed: 2022-04-29
Abstract: The present invention the novel ointment composition based on milkfat obtained from human breast milk and combined with a synergistically beneficial ratio of medium chain triglycerides to milk fat from human breast milk.
Patent CA-3160662-A1 (CA)
Inventor: GE ZHONGXIN
IPC: H01M10/0567
Filed: 2020-11-18
Abstract: La présente invention concerne des solutions électrolytiques non aqueuses pour des batteries au lithium. Les solutions électrolytiques non aqueuses comprennent un milieu électrolytique liquide ; un sel contenant du lithium ; et au moins un agent ignifuge bromé contenant de l'oxygène.