baber/WOPTO huggingface dataset:
Patent RU-2744691-C2 (RU)
Inventor: AVERBACK PAUL
IPC: C07K7/00
Filed: 2017-08-29
Granted: 2021-03-15
Abstract: FIELD: biotechnology. 
     SUBSTANCE: invention relates to the field of biotechnology, specifically to a method for reducing or preventing acerbation or progression of symptoms of benign prostatic hyperplasia (BPH). 
     EFFECT: proposed method, which involves administering a therapeutically effective amount of peptide containing an amino acid sequence with SEQ ID NO: 66, reduces acerbation or progression of symptoms of BPH in accordance with the International Prostatic Symptom Scale (IPSS) by more than 10%.  
     16 cl, 8 tbl, 8 ex
Patent RU-2766331-C2 (RU)
Title: Liraglutide synthesis
Inventor: GANGA RAMU VASANTAKUMAR
IPC: C07K14/605
Filed: 2017-12-09
Granted: 2022-03-15
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to the effective solid-phase synthesis of liraglutide represented by the Formula-I. A method includes following stages: a) loading of C-terminal glycine onto resin-based solid-phase substrate in the presence of a binding agent; b) capping of unreacted functional sites; c) sequential binding of N α -protected amino acids and amino acids with protected side chains to obtain a liraglutide backbone in the presence of the binding agent and inorganic salt; d) removal of the protective group of the lysine side chain; e) binding of glutamic acid and palmitic acid to the lysine side chain in the presence of the binding agent and inorganic salt; and f) obtaining crude liraglutide by removing protective groups and cleaving peptide from resin; where the method includes binding of amino acids 9-13 at an elevated temperature in the range from 30 to 45°C, where the specified inorganic salt is present as a catalyst and is selected from a group consisting of magnesium chloride, zinc chloride and copper chloride, where the stage (c) includes the removal of Fmoc protection of each loaded amino acid using piperidine in DMF (N,N'-dimethylformamide) or a mixture of piperidine/DBU (1,8-diazabicyclo[5.4.0]undets-7-en)/DMF, where, after each stage of removal of Fmoc protection, a washing stage is carried out using HOBt (N-hydroxybenzotriazole) in DMF, as well as removal of the methyl trityl protective group of lysine.  
     EFFECT: method provides avoiding deletion of sequences and leads to an increase in yield. 
     12 cl, 2 dwg, 7 ex
Patent RU-2749600-C2 (RU)
Title: Method and unit for synthesis of nitric acid, method for improvement
Inventor: CEREA IACOPO
IPC: C01B21/46
Filed: 2018-02-01
Granted: 2021-06-15
Abstract: FIELD: chemistry.SUBSTANCE: invention relates to the area of industrial production of nitric acid. A double-pressure unit for synthesis of nitric acid comprises: a reactor (4) wherein an off-gas stream (15) containing nitrogen oxides is formed; an absorption column (6) wherein nitrogen oxides react with water producing crude nitric acid; a compressor (5) increasing the pressure of the off-gas stream (15) of the reactor to the absorption pressure. The absorption tower (6) operates at a pressure exceeding the pressure in the reactor. The unit also comprises a first scrubber (37) and a second scrubber (7). The first scrubber (37) desorbs nitrogen oxides from the outlet stream (27) of the absorption column (6) product by air (39) producing a partially purified nitric acid stream (40) and a stream of air (41) saturated with nitrogen oxides, wherein the first stream is supplied to the second scrubber (7) and the second stream is returned to the discharge side of the compressor (5).EFFECT: increased productivity of the unit and synthesis of nitric acid of higher purity are ensured.15 cl, 2 dwg
Patent RU-2750883-C2 (RU)
Title: Method for concreting at subzero temperatures
Inventor: MUKHAMETRAKHIMOV RUSTEM KHANIFOVICH
IPC: C04B103/32
Filed: 2019-12-23
Granted: 2021-07-05
Abstract: FIELD: construction industry.SUBSTANCE: invention relates to construction industry and can be used in the production of reinforced concrete and concrete monolithic structures of buildings and facilities at an accelerated rate of their construction and work implementation at negative temperatures. The method for concreting at negative temperatures consists in adding the ground conductive mineral shungite to the building mixture- that of Class B30 concrete and exposing them to an electric field created by passing a direct electric current through the building mixture by connecting electrodes. At the same time, the content of the conductive mineral shungite is 1-10% of the weight of the Portland cement that is part of the building mixture, the degree of grinding of shungite being 200-400 m2/kg.EFFECT: invention is aimed at increasing the rate of concrete strength gain at negative temperatures.1 cl, 1 dwg, 1 tbl
Patent RU-2758156-C2 (RU)
Inventor: BENDJELLAL FARID
IPC: B60N2/26
Filed: 2020-02-18
Granted: 2021-10-26
Abstract: Изобретение относится к детскому креслу безопасности. Детское кресло безопасности содержит три запирающих механизма, поверхность сиденья кресла и соединительный элемент. Запирающие механизмы выполнены с возможностью прикрепления кресла к транспортному средству в соответствующей точке крепления с возможностью отсоединения. Причем точки крепления первого и второго запирающих механизмов расположены на одной линии, а точка крепления третьего запирающего механизма расположена на расстоянии от этой линии. Поверхность сиденья кресла обеспечивает посадочную область кресла. При этом третий запирающий механизм выполнен с возможностью регулирования по высоте относительно поверхности сиденья. Причем третий запирающий механизм прикреплен к креслу с помощью соединительного элемента. При этом соединительный элемент выполнен с возможностью регулирования по высоте для обеспечения возможности регулирования по высоте третьего запирающего механизма. Повышается безопасности пассажира при эксплуатации. 2 н. и 16 з.п. ф-лы, 9 ил.
Patent RU-2762193-C2 (RU)
Title: Use of ep4 receptor antagonists for treatment of nash-associated liver cancer
Inventor: OHTANI NAOKO
IPC: C07D471/04
Filed: 2017-11-02
Granted: 2021-12-16
Abstract: FIELD: medicine. 
     SUBSTANCE: invention relates to a method for the treatment of NASH-associated liver cancer, which includes the administration of pharmaceutically effective amount of 3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridine-1-yl}phenyl)ethyl]-1-[(4-methylbenzene)sulfonyl]urea (compound C) or its pharmaceutically acceptable salt to a person or animal in need of it.  
     EFFECT: new method is developed for the treatment of NASH-associated liver cancer by means of prostaglandin E2 receptor 4 (EP4) antagonist, which is a compound C, which can be used in medicine. 
     4 cl, 8 dwg, 6 ex
Patent RU-2769133-C2 (RU)
Inventor: WU CHENGBIN
IPC: A61K39/395
Filed: 2014-12-24
Granted: 2022-03-28
Abstract: FIELD: biochemistry. 
     SUBSTANCE: group of inventions relates to multivalent and multispecific binding proteins and an application thereof. Binding protein contains three polypeptide chains: the first polypeptide chain contains, from the amino terminus to the carboxy terminus, (i) VLA-CL-VHB-CH1-Fc, where CL is fused directly to VHB, or (ii) VHB-CH1-VLA-CL-Fc, where CH1 is fused directly to VLA, and wherein there are no inserted linkers between the variable domains and constant domains; the second polypeptide chain contains, from the amino terminus to the carboxy terminus, VHA-CH1, wherein there are no inserted linkers between VHA and CH1; the third polypeptide chain contains, from the amino terminus to the carboxy terminus, VLB-CL, wherein there are no inserted linkers between VLB and CL. Two of said first polypeptide chains, two of said second polypeptide chains, and two of said third polypeptide chains are therein capable of associating forming a tetravalent binding protein with double specificity containing six polypeptide chains containing four Fab functional binding fragments. Said binding protein binds both epitope or antigen A and epitope or antigen B. A and B therein constitute different epitopes of the same antigen or different antigens. 
     EFFECT: binding proteins can be used for treating or preventing acute and chronic inflammatory diseases and disorders, autoimmune diseases, malignant tumours, and other diseases and disorders; proposed structure provides sufficient flexibility and corresponding dimensional parameters for double binding in the absence of a peptide spacer between 2 Fab-binding regions. 
     32 cl, 7 dwg, 16 tbl, 4 ex
Patent UA-66241-C2 (UA)
Title: Collected information-measuring system of power unit of an aircraft
Inventor: BEZSCHASTNYI VASYL OLEKSIIOVYC
IPC: F02C9/28
Filed: 2003-09-04
Abstract: The storage information-measuring system of power unit of the aircraft provides increase of operation characteristics and coefficient of the equipment use. That for to the system including two blocks of formers, two blocks of normalizers, two blocks for sensor control, two switchboards, two analog-digital converters, two blocks for registration of the parameters, two operation blocks and control block additionally are included: the block for frequency control, the block of reference frequency, block of standards, frequency switch, block of galvanic decoupling, switch of single signals, switchboard for the airborne power system, additional operation block, block of frequency control, block of standard frequency, frequency switchboard, block of standards, the block of galvanic decoupling, switchboard for single signals, switchboard of airborne power and operation block.
Patent UA-79755-C2 (UA)
Title: Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
Inventor: LOWE DEREK B
IPC: C07D277/28
Filed: 2002-07-25
Abstract: This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. Theinvention also relates to intermediates of formula (II) and (III) of indane acetic derivatives and to methods of preparation.
Patent UA-89941-C2 (UA)
Title: Phenyliso(thio)cyanates, processes and intermediates for their preparation
Inventor: HAMPRECHT GERHARD
IPC: C07D213/76
Filed: 2003-10-29
Abstract: The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula () or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxygen or sulfur and Ar and A have the meanings as cited in Claim 1. The invention also relates to the use of phenyliso(thio)cyanates for producing plant protection products.
Patent UA-79969-C2 (UA)
Title: Analyzer of burning gases
Inventor: KOTLIAROV OLEKSANDR KOSTIANTYN
IPC: E21F17/18
Filed: 2005-01-05
Abstract: An analyzer of burning gases has lower supply block, electronic circuit for information processing, indicators of low and high concentrations of methane, blocks for light and sound signaling, knobs for switch-on and setting modes of operation of analyzer. There are included indicator of burning gases that has connected in sequence working and compensation sensitive elements, in parallel to those connected in sequence ballast resistors of bridge measuring circuit are connected, at that two first ballast resistors and working and compensation sensitive elements form thermo-catalytic indicator of low concentrations of methane, its output is connected to the first input of electronic circuit of information processing, to its other input compensation sensitive element is connected, this is used as indicator of high concentrations of methane. To the third inputs of electronic circuit other ballast resistors of bridge measuring circuit of burning gas indicator are connected. To the fourth and the fifth inputs of electronic circuit knobs for switch-on and setting modes of operations, respectively are connected, and to outputs of electronic circuit blocks of digital indication, sound and light signaling are connected, and, if needed, block for disconnection of object protected and block for data transfer. The analyzer provides increase of reliability of gas protection.
Patent UA-83497-C2 (UA)
Title: Protective device for blast isolation
Inventor: VAMBOL SERHII OLEKSANDROVYCH
IPC: F42D5/05
Filed: 2006-02-07
Abstract: A protective device for blast isolation has cylindrical fiberglass shell made of piroelectric material and coaxially placed inside and outside of it with direct contact metal shells between which with high-voltage wire transformer of electric energy is connected. To increase reliability of the device due to increase of part of electric energy taken from protective shell, transformer of electric energy is arranged as piezoelectric emitter placed in water.
Patent UA-85755-C2 (UA)
Title: body of centrifugal pump
Inventor: PROKOPENKO VOLODYMYR ILLICH
IPC: F04D29/42
Filed: 2007-04-20
Abstract: A body of centrifugal pump has inlet and outlet covers between which sections are installed. The sections are arranged as discs between which spacers as rings are placed, discs have lugs at each side, and the rings are arranged with depressions. The disc installed between the inlet cover and the ring has a form corresponding to lengthwise truncated tore with bell-shaped depression with broken inner and outer surfaces. Such implementation of the body provides reliable tightening and technological effectiveness.
Patent UA-86456-C2 (UA)
Title: Hydraulic jack
IPC: B66F3/24
Filed: 2007-05-08
Abstract: A hydraulic jack has a body in which piston is placed, the body and piston are arranged in such way that cylindrical surfaces of those are two friction pairs with different diameters, between cylindrical surfaces of friction pairs there is a cavity formed with working surface of the body and the nozzle connected by channel to flexible hose for oil supply connected to the body, in the body and the piston in thicker walls in zone of cylindrical surfaces grooves are provided, there round in cross section tightening rings are placed, those are made of elastic material, and protective rings made of more rigid material, rings with round cross section are installed at side of the cavity. To increase operating force of the jack, to decrease concentration of tension of metal of thicker part of the piston and the body and to provide reliable tightening working surfaces of the body and the piston are arranged at angle to cylindrical surfaces, at that places where cylindrical surfaces go to working ones and placed of transition of cylindrical surfaces of grooves at side of installation of protective ring to end surfaces of grooves are arranged in radii, at that grooves are arranged in such way that one side of those is opened to cavity, and protective rings have thickness larger than thickness of sealing ring, and form providing adjoining to sealing ring and to radius of groove as well.
Patent UA-87065-C2 (UA)
Title: Method for obtaining of plant antiulcerous remedy
Inventor: VLADYMYROVA INNA MYKOLAIVNA
IPC: A61K36/31
Filed: 2008-01-14
Abstract: The invention relates to a method for obtaining of plant antiulcerous remedy which comprises the reiterated extraction of vegetable raw material with hot water in the ratio of raw material: extractant of 1:10 with subsequent filtration and drying of total extract, at that broccoli herb is used as the vegetable raw material, the extraction is carried out by the maceration twice at a temperature of 70- during 1,5-2 hours, at that the first extraction foresees the increase of extractant amount taking into account the coefficient of its absorption by raw material. The yield of the prepared product is more than 31 % of air-dry raw material.
Patent UA-91140-C2 (UA)
Title: method for reparative THERAPY UNDER CONDITIONS OF Poisoning of animals with cadmium
Inventor: MELNYCHUK DMYTRO OLEKSIIOVYCH
IPC: A61D99/00
Filed: 2008-11-26
Abstract: The invention relates to veterinary and medicine, in particular to methods for activation of reparative processes in internals at poisoning of animals with cadmium, providing the use of liposomal form of biologically active additive FLP-MD.
Patent UA-91924-C2 (UA)
Title: Internal combustion engine
Inventor: FIGL GERHARD
IPC: F01L9/20
Filed: 2007-06-12
Abstract: Internal combustion engine having at least one piston cylinder (1), having a housing (3) which encloses twin gas injectors (2) and has two inlet openings (4) for the separate supply of hydrogen gas and oxygen gas into the combustion chamber (5) of the piston cylinder, having two pressure-controlled and time-controlled, electrical inlet valves (6) and associated nozzle needles (7) in the housing, wherein the combustion chamber has an outlet opening (15) for ejecting the combustion product and a thermolysis catalyst (20) forms the combustion-chamber covering, which thermolysis catalyst (20) has two hollow cylinders (25, 26) which are spaced apart from one another, are arranged concentrically and enclose an intermediate space (27), wherein those walls of the hollow cylinders which delimit the intermediate space are provided with a metal coating (28) for dissipating the combustion heat which loads the inner hollow cylinder, and wherein the outer hollow cylinder is provided with an inlet opening (29) for the supply of water, an outlet opening (30) for the discharge of oxyhydrogen gas and a temperature sensor (31) for water-supply control.
Patent UA-94140-C2 (UA)
Title: Roller of belt conveyor
Inventor: FODLASH VLADYMYR DANYLOVYCH
IPC: B65G39/00
Filed: 2009-07-10
Abstract: The present invention relates to a belt conveyer used in various industries for transportation of bulk materials under conditions of high fire and explosion hazards, particularly in the coal mines.A roller of belt conveyor consists of a metallic hollow cylinder, bearings, and seals.To simplify the design of the roller and reliability of its operation in the internal part of cylinder are located textolite sliding sleeves in the shell fixed by lock washers with a diameter, which is smaller than the internal diameter of the cylinder, and the press-fit bearing bodies are located at the ends.In addition, the cylinder and cap are made of flame-retardant polymer material with antistatic properties, and sealing is performed by lithium soap (liquid gasket).
Patent UA-95675-C2 (UA)
Title: Device for study of adhesive properties of lubrication materials
Inventor: ZHELEZNYI LEONID VITALIIOVYCH
IPC: G01N19/04
Filed: 2009-10-28
Abstract: A device is intended for determination of operation properties of lubrication materials, in particular adhesive properties of lubricants that are used in friction units of machines and mechanisms, it consists of high-speed electric motor with automated control of number of revolutions, indicator of duration of test, flat working disc that is fit to the output shaft of the motor and installed to the chamber where by means of heater increased temperature can be supported, and by means of cold agent – temperature lower than 0° C. The working disc has sockets to which shaped plates are installed, to those the lubricant under investigation is applied, and effect of air flow on it is leveled with protective screens.
Patent UA-98990-C2 (UA)
Title: Device for preparing beverage comprising adjustable closing mechanism
Inventor: BONACCI ENZO
IPC: A47J31/36
Filed: 2008-12-15
Abstract: The present invention proposes a device (50) for preparing a beverage from a food substance contained in a capsule (24) by injection of a liquid into the capsule (24) provided to the device (50). Said liquid is provided by a pump of the device, said device comprising an extraction head (20) having an aperture (2.2) for inserting a capsule (24) into a brewing chamber (25) of the device. The brewing chamber (25) is defined by an upper and a lower enclosing member (10a, 10b), a closing mechanism (1) to selectively enclose said capsule by a relative displacement of said enclosing members. The enclosing members are designed for being transferred between an open insertion position for inserting a capsule (24) into the brewing chamber (25) and a closed injection position for enclosing the capsule within the brewing chamber (25), and adjustment means (3a, 3b, 9b, 9c, 7a, 7b, 8a) connected to at least one of said enclosing members (10a, 10b) in order to adjust the relative position of the enclosing members and hence the - closing force of the closing mechanism (1).
Patent UA-103018-C2 (UA)
Title: Benzodiazepine compounds and pharmaceutical composition
Inventor: OSHIMA KUNIO
IPC: A61P9/06
Filed: 2009-02-20
Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel or the IKACH current (the GIRK1/4 channel) potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
Patent UA-100804-C2 (UA)
Title: Fungus strain penicillium roseopurpureum - producer of curvularine
Inventor: HAVRILOV VALERII ALIEKSANDROVICH
IPC: C12N1/14
Filed: 2011-09-14
Abstract: The invention relates to microbiology and relates to the novel fungus strain Penicillium roseopurpureum, which can be used for production of mycotoxin (secondary metabolite), curvularine, which as part of preparations with fungicide activity is used for prevention and protection of drug plants, horticultural, ornamental and other agricultural cultures from diseases. The strain Penicillium roseopurpureum – producer of curvularine, is deposited in depository of microorganisms of Zabolotnyi Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine under register number IMB F-100055.
Patent UA-105380-C2 (UA)
Title: Casting nozzle for horizontal continuous casting system
Inventor: EICHHOLZ HELLFRIED
IPC: B22D41/50
Filed: 2010-02-15
Abstract: The invention relates to a casting nozzle for a horizontal continuous casting system, especially for casting steel strip. Said casting nozzle is connected to a feed channel and is designed as a rectangular refractory hollow ingot the outlet region of which is only slightly above the cooled continuous strip which accommodates the emanating melt. The hollow ingot is subdivided at least once in the direction of casting and a narrow sealing element is arranged on the division side of the segments, the width of the remaining gaps in the division area being chosen such that they are closed when the casting nozzle is operated.
Patent UA-104326-C2 (UA)
Title: Discontinuous centrifuge for adjustment of filler quantity and method of control of operation of such centrifuge
Inventor: JANSSEN VIKTOR
IPC: B04B11/00
Filed: 2010-07-15
Abstract: A discontinuous centrifuge for the solid-liquid separation of a crystal suspension comprises a centrifuge drum (2), the rotational axis (3) of which coincides with the axis of symmetry of the cylindrical wall (7) of the centrifuge drum (2) and is vertically disposed, mid into which the crystal suspension can be filled as a filling product (9) in a predetermined quantity, and a continuously measuring distance measuring sensor (15), which is disposed on the inside of the centrifuge drum (2), always outside of the filling product (9), in order to determine a distance (A1 to A4) to the free surface (10 to 13) of the filling product (9) in a measuring surface (17) that is rotationally symmetrical about the rotational axis (3) and substantially perpendicular to the rotational axis, and a controller, which is equipped to establish the quantity of the filling product during the subsequent pouring depending on the distance (A1 to A4).