baber/WOPTO huggingface dataset:
Patent EP-3812471-A1 (EP)
Inventor: CHO YOUNGNAM
IPC: C12Q1/6837
Filed: 2019-05-30
Abstract: In an embodiment, the present invention relates to a technique in which small-sized cfDNA is detected, with ultrahigh sensitivity, from a liquid sample such as urine, cerebrospinal fluid, plasma, blood, pleural fluid, or body fluid, is concentrated and isolated, and then is analyzed for gene mutations without PCR. In particular, in a case where a positively charged nanostructure is used, capture and detection rates for cfDNA can be increased. A detection method according to an embodiment of the present invention does not require a PCR amplification reaction, which greatly shortens the time taken to obtain a result. In addition, since direct on-site analysis is possible without the need for specific equipment, it is expected that the present invention can be used as a point-of-care testing (POCT) capable of simultaneously searching multiple genes in a short period of time.
Patent EP-3814349-A1 (EP)
Inventor: VIRCA NICHOLAS J
IPC: C07D487/04
Filed: 2019-05-30
Abstract: The present invention concerns methods for treating high-risk basal cell carcinoma (BCC) or high-risk basal cell carcinoma nevus syndrome (BCCNS) in a subject, comprising administering a composition comprising an azole inhibitor of the Hedgehog signaling pathway (azole inhibitor) to the subject.
Patent EP-3805386-A1 (EP)
Inventor: YAMAGATA TETSUYA
IPC: C07K19/00
Filed: 2019-06-07
Abstract: A protein having a binding ability to guide RNA and consisting of a sequence containing an amino acid sequence wherein a continuous deletion region is present between the 481-position and the 649-position in the amino acid sequence shown in SEQ ID NO: 2, the deletion region containing 
(i) all or a part of L1 domain (481- to 519-positions), and 
(ii) entire HNH domain (520- to 628-positions), and further optionally containing 
(iii) all or a part of L2 domain (629- to 649-positions), wherein amino acids adjacent to each of the deletion region are linked by a linker consisting of 3 to 10 amino acid residues functions as a miniaturized dSaCas9 protein while maintaining DNA binding affinity. Use of the miniaturized dSaCas9 protein makes it possible to mount many genes into vectors.
Patent EP-4070459-A1 (EP)
Inventor: FREDRIKSSON HENRIK
IPC: H03M1/68
Filed: 2019-12-05
Abstract: A method of weight calibration in a DAC (25) is disclosed. The DAC (25) comprises an input port (100) for receiving a sequence of digital input words ( x [ n ]), each representing a digital input sample, and a digital control circuit (110) configured to encode each digital input word ( x [ n ]) into a control word ( z [ n ]) representing the same digital input sample. Each bit ( Z 
   i   ) in the control word ( z [ n ]) has a corresponding bit weight ( w 
   i   ) and is in the following considered to adopt values in {-1, 1}. Furthermore, the DAC (25) comprises a set (120) of analog weights, each associated with a unique one of the bits ( Z 
   i   ) in the control word ( z [ n ]), and summation circuitry (130) configured to generate an analog sample corresponding to the digital input sample by summing the bits in the control word ( Z 
   i   ) weighted by the respective associated analog weights. The DAC (25) also has an output (140) for outputting the analog sample. The method comprises, during a measurement procedure, for a first set of at least one bit of the control word (z[n]), generating (300) the bits of the first set, such that a first sum of the bits in the first set weighted by their respective bit weights is, on average, above zero. Furthermore, the method comprises, during the measurement procedure, for a second set of at least one bit of the control word ( z [ n ]), generating (310) the bits of the second set, such that a second sum of the bits in the second set weighted by their respective bit weights is, on average, below zero and such that the sum of the first sum and the second sum is, on average, equal to zero. The method also comprises detecting (330) a DC level at the output of the DAC during the measurement procedure. The method further comprises adjusting (340) at least one analog weight in response to the detected DC level. A corresponding DAC, a corresponding electronic apparatus, and a corresponding integrated circuit are also disclosed.
Patent EP-3887044-A1 (EP)
Inventor: Willshare Thomas Michael
IPC: B01L3/00
Filed: 2019-11-28
Abstract: Disclosed is a microfluidic cassette comprising a microfluidic cassette body comprising at least one fluid flow channel, and at least one chamber containing reagent.The chamber comprises a seal to prevent fluid from entering the chamber. The seal is breakable in situ in the cassette body. The cassette body and the chamber are configured such that when the seal is broken, the reagent is exposed to fluid flow in the channel.
Patent EP-3918074-A1 (EP)
Inventor: BIALAS KATARZYNA
IPC: C12N15/115
Filed: 2019-11-27
Abstract: La présente invention concerne, entre autres, des aptamères qui se lient spécifiquement à l'irinotécan et des procédés d'utilisation de ceux-ci.
Patent EP-3808043-A1 (EP)
Inventor: INGERMAN MARK M
IPC: H04L12/801
Filed: 2019-06-12
Abstract: Among other things, this document describes systems, devices, and methods for wireless content delivery to vehicles and in particular to vehicles in cellular radio environments. The teachings hereof can he used to deliver a vehicle manufacturer's head unit updates, firmware, configurations, and other data to a vehicle. In embodiments, downloads are managed at the control plane and/or data plane. Download management can include mitigating either current or anticipated wireless congestion at cell towers, enforcing campaign priority for firmware updates, accommodating occupant-originated data flows to and from the vehicle, and/or accounting for contractual data arrangements between vehicles makers and cellular providers, among other things.
Patent EP-3816150-A1 (EP)
Title: M-diamide compound and preparation method therefor and use thereof
Inventor: LV LIANG
IPC: A01N37/48
Filed: 2019-03-12
Abstract: Provided are m-diamide compounds and a preparation method therefor and the use thereof. The m-diamide compounds have a structure represented by formula I. The m-diamide compounds of the present invention can have a high insecticidal activity at a low dose and take effect rapidly, can exert the insecticidal activity one day after application, can achieve a high insecticidal activity within three days, and have a good fast-acting property; moreover, due to the good effect at a low dose, the m-diamide compounds can reduce the damage to plants and human beings caused by excessive drug concentrations, enable less drug residue to be generated during application which is more conducive to environmental protection, and have broad application prospects.
Patent EP-3898776-A1 (EP)
Inventor: JOFFRE ERIC
IPC: C09D183/04
Filed: 2019-12-04
Abstract: L'invention concerne un organohydrogénosiloxane polyfonctionnel et un procédé pour sa préparation à l'aide d'un acide de Lewis contenant du bore en tant que catalyseur. Un organosiloxane fonctionnel en grappe peut être préparé par un procédé comprenant la fonctionnalisation de l'organohydrogénosiloxane polyfonctionnel. L'organohydrogénosiloxane polyfonctionnel et l'organosiloxane fonctionnel en grappe sont utiles dans des compositions durcissables. L'organohydrogénosiloxane polyfonctionnel peut être utilisé dans une composition de revêtement antiadhésive. L'organosiloxane fonctionnel en grappe peut être utilisé dans une composition adhésive.
Patent EP-3820468-A1 (EP)
Title: Use of sustained-release 5-hydroxytryptophan in treating gastrointestinal disorders
Inventor: JACOBSEN JACOB P R
IPC: A61K31/405
Filed: 2019-07-10
Abstract: The present invention provides,  inter alia , methods for treating or ameliorating a gastrointestinal (GI) condition such as constipation in a subject in need thereof, using a sustained release formulation of 5-hydroxytryptophan (5-HTP SR). A kit comprising 5-HTP SR is also provided.
Patent EP-3832567-A1 (EP)
Inventor: NAKANISHI KENICHI
IPC: G06Q10/08
Filed: 2019-07-12
Abstract: An integrated management server comprising: a data formatting means for receiving sales record information from a plurality of distributor terminals of a plurality of distributors which are selling products to retailers; a data matching means for updating brand master information for universally managing alcoholic beverage brands sold to the retailers across the plurality of distributors based on each of the received sales record information; and a brand Identification means for analyzing image related information received from a user terminal, identifying an alcoholic beverage brand by comparing a feature information corresponding to an alcoholic beverage brand registered in the brand master information, and sending information related to identified alcoholic beverage brand to the user terminal; and the user terminal comprising: a display means for displaying information on the sent alcoholic beverage brand.
Patent EP-3841169-A1 (EP)
Inventor: MOHARRAM TAREK
IPC: C12P1/04
Filed: 2019-08-23
Abstract: A biodegradable polymer composition, according to the present invention, comprises polyhydroxybutyrate and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) blended with thermoplastic starch, one or more compatibilizers selected from the group consisting of dihexyl sodium sulfosuccinate and maleic anhydride, and one or more additives selected from the group consisting of microcrystalline cellulose and cellulose. Methods of producing a biodegradable polymer use processed cannabis waste as a carbon source.
Patent EP-3846842-A1 (EP)
Inventor: RICHTER SHACHAR
IPC: A61K33/38
Filed: 2019-09-03
Abstract: The invention disclosed herein relates to a method of producing metal particles of a preselected form in a biological system such a glycoprotein.
Patent EP-3848367-A1 (EP)
Inventor: LEI MAOYI
IPC: C07D413/00
Filed: 2019-09-09
Abstract: The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.
Patent EP-3951756-A1 (EP)
Inventor: LIU PENG
IPC: G09G3/20
Filed: 2019-03-28
Abstract: A gate driving unit, a gate driving method, a gate driving circuit, a display panel and a display device are provided. The gate driving unit includes a start terminal, a first gate driving signal output terminal, a second gate driving signal output terminal, a pull-up control node control circuit, a pull-up node control circuit, configured to control a potential of a fist pull-up node and a potential of a second pull-up node based on the potential of the pull-up control node, a first gate driving signal output circuit, a second gate driving signal output circuit, and a pull-down node control circuit, configured to control and maintain the potential of the pull-down node under the control of a third clock signal and a fourth clock signal, and control to reset the potential of the pull-down node under the control of the potential of the pull-up control node.
Patent EP-3692936-A1 (EP)
Inventor: WANG CAIMEI
IPC: A61B17/64
Filed: 2019-01-17
Abstract: Provided are a locking steel plate and a locking steel plate assembly with the locking steel plate. Herein, the locking steel plate may include a steel plate body, an elastic block hook and a limit groove. The steel plate body is provided with a mounting hole, and the mounting hole may include a first hole section and a second hole section having a cross section area less than that of the first hole section. The elastic block hook is provided inside the first hole section, a first end of the elastic block hook is connected with the steel plate body, and a second end of the elastic block hook bends toward the second hole section. The limiting groove is provided on an inner wall of the second end of the elastic block hook. With the adoption of the technical solution of the application, inconvenient operation caused when an additional assembly prevents the locking steel plate from getting loose in the related art may be effectively solved.
Patent EP-3860260-A1 (EP)
Inventor: YANG XIAODONG
IPC: H04W72/04
Filed: 2019-09-20
Abstract: The present disclosure provides a method for determining a sidelink resource and a device. The method includes: determining, based on at least one of preset information and a preset parameter, a target sidelink SL resource for a target SL service from candidate SL resources; where the preset information includes either of related information of a resource used by a Uu interface of the terminal device and an attribute of a carrier carrying the target SL resource; and the preset parameter includes at least one of a utilization rate of the candidate SL resources and a communication quality parameter of the candidate SL resources.
Patent EP-3734738-A1 (EP)
Inventor: OH JEONG WOO
IPC: H01M10/0567
Filed: 2019-09-27
Abstract: The present invention relates to a non-aqueous electrolyte solution and a lithium secondary battery including the same, and, particularly, to a non-aqueous electrolyte solution, which includes a 1.2 M to 3.3 M lithium salt, a first organic solvent composed of ethylene carbonate, a second organic solvent excluding the ethylene carbonate, and an oligomer represented by Formula 1 as a first additive, wherein the first organic solvent is included in an amount of 0.1 wt% to 12 wt% based on a total weight of the non-aqueous electrolyte solution, and a lithium secondary battery including the same.
Patent EP-3857094-A1 (EP)
Inventor: CALLAGHAN MARK
IPC: G01N3/56
Filed: 2019-09-26
Abstract: A wear sensor for use in a wear sensing fastener, the wear sensor fastener comprising a head which in use is exposed to wear, the head has a shank extending therefrom, a sensor portion having a probe received within the shank such that an end of the probe terminates at or adjacent an exposed surface of the head, the probe comprising a plurality of resistive elements positioned along the probe, wherein each resistive element is individually measurable, whereby in use those resistive elements which do not return a result provide an indication of wear experienced by the probe.
Patent EP-3861331-A1 (EP)
Inventor: FAN XUDONG
IPC: G01N30/62
Filed: 2019-10-02
Abstract: L'invention concerne un détecteur à photoionisation (PID) microfluidique intégré comprenant une chambre d'ionisation microfluidique et une chambre de rayonnement ultraviolet microfluidique conçue pour générer des photons ultraviolets. Une fenêtre transmissive ultramince est disposée entre la chambre d'ionisation microfluidique et la chambre de rayonnement ultraviolet microfluidique permettant aux photons ultraviolets de passer de la chambre de rayonnement ultraviolet microfluidique à la chambre d'ionisation microfluidique. L'Invention concerne également des systèmes de détection d'un ou plusieurs analytes de COV comprenant une unité de chromatographie en phase gazeuse (GC) comprenant au moins une colonne de chromatographie en phase gazeuse et un détecteur à photoionisation (PID) microfluidique intégré disposé en aval de l'unité de chromatographie en phase gazeuse (GC).
Patent EP-3870121-A1 (EP)
Inventor: KAHOOK MALIK Y
IPC: A61F9/007
Filed: 2019-10-16
Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.
Patent EP-3796451-A1 (EP)
Inventor: ZHU JIANWEI
IPC: H01M10/0567
Filed: 2019-10-30
Abstract: This application relates to the field of batteries, and in particular, to an electrolytic solution and a lithium-ion battery, a battery module, a battery pack and an apparatus that adopt the electrolytic solution. This application provides an electrolytic solution, including an electrolyte and a solvent, and further including an additive A and an additive B. The additive A is selected from at least one of compounds whose chemical structural formula is denoted by Formula I, and the additive B is selected from at least one of compounds whose chemical structural formula is denoted by Formula II. In the electrolytic solution provided in this application, the additive A and the additive B are introduced into the electrolytic solution of a lithium-ion battery. By using the additive A and the additive B together, this application enables films to be formed on surfaces of a positive electrode plate and a negative electrode plate concurrently, and enables formation of a highly polymerized, highly ordered, low-resistance tough meshed organic film on the surface of the negative electrode, thereby significantly improving cycle performance and high-temperature storage performance of the lithium-ion battery, and also ensuring excellent kinetic performance of the lithium-ion battery.
Patent EP-3887457-A1 (EP)
Inventor: BRAY PAUL A
IPC: C09D5/08
Filed: 2019-09-25
Abstract: A method of creating a selectively plated three-dimensional thermoplastic part. The method includes the steps of: a) providing a film of uncured polycarbonate film having a hardcoated layer on a first surface thereof; b) selectively catalyzing the polycarbonate film by depositing a catalyst in a desired pattern on the first surface of the polycarbonate film; c) thermoforming the polycarbonate film to form a three-dimensional polycarbonate film; d) UV- curing the hardcoated polycarbonate film by irradiating the film with UV rays; e) molding the hardcoated polycarbonate film to produce a three-dimensional molded part comprising the hardcoated polycarbonate film; f) activating the selectively catalyzed hardcoated polycarbonate film; and g) plating a metal layer on the catalyzed portions of the hardcoated polycarbonate film, wherein the plated metal only deposits on the catalyzed portions of the hardcoated polycarbonate film.
Patent EP-3893610-A1 (EP)
Inventor: ONOHARA JUN
IPC: H03H7/01
Filed: 2019-11-25
Abstract: Provided are circuit boards which are compact but have excellent electromagnetic shielding properties, for use in small-size, high-speed and high-capacity communication devices. The circuit board includes a glass substrate having a first surface and a second surface facing away from the first surface; a first coil wiring pattern formed on the first surface and a second coil wiring pattern formed on the second surface, the first and second coil wiring patterns constituting part of a coil; a through hole extending through a predetermined portion of the glass substrate from an end of the first coil wiring pattern to an end of the second coil wiring pattern; a through hole inner conductive surface formed on the inner side of the through hole, the through hole inner conductive surface enabling electrical connection between the end of the first coil wiring pattern and the end of the second coil wiring pattern, the first and second coil wiring patterns and the through hole inner conductive surface constituting the coil wound around a direction perpendicular to an axis of the through hole and to a direction in which the first and second coil wiring patterns extend; and an electromagnetic shielding layer comprised of conductive material, the electromagnetic shielding layer shielding against electromagnetic waves generated by the coil.
Patent EP-3892747-A1 (EP)
Inventor: JEONG HAE-KWON
IPC: C23C2/00
Filed: 2019-06-11
Abstract: An apparatus for cooling a steel sheet according to the present invention comprises: an apparatus body provided spaced apart from a steel sheet in the conveying path of the steel sheet; and a cooling unit provided in the apparatus body to supply a cooling fluid. The apparatus body includes: a first edge body that faces a first edge portion extending a certain distance from one side end of the steel sheet toward the center of the steel sheet; and a second edge body that faces a second edge portion extending a certain distance from the other side end of the steel sheet toward the center of the steel sheet. The first and second edge bodies may have stepped cross-sections in a direction perpendicular to the conveying direction of the steel sheet.
Patent EP-3891560-A1 (EP)
Inventor: OZCAN AYDOGAN
IPC: G03H1/08
Filed: 2019-12-03
Abstract: A UV holographic imaging device offers a low-cost, portable and robust technique to image and distinguish protein crystals from salt crystals, without the need for any expensive and bulky optical components. This "on-chip" device uses a UV LED and a consumer-grade CMOS image sensor de-capped and interfaced to a processor or microcontroller, the information from the crystal samples, which are placed very close to the sensor active area, is captured in the form of in-line holograms and extracted through digital back-propagation. In these holographic amplitude and/or phase reconstructions, protein crystals appear significantly darker compared to the background due to the strong UV absorption, unlike salt crystals, enabling one to clearly distinguish protein and salt crystals. The on-chip UV holographic microscope serves as a low-cost, sensitive, and robust alternative to conventional lens-based UV-microscopes used in protein crystallography.
Patent EP-3895563-A1 (EP)
Inventor: QIAN JIANBING
IPC: A24B3/14
Filed: 2019-04-30
Abstract: The present invention provides a heat-not-burn (HNB) cartridge structure, comprising a cartridge packaging housing and HNB tobacco particles contained therein. The cartridge packaging housing is composed of a cartridge cup, a cover film and sealing films. The cartridge cup is provided with a top opening and a bottom end face; the cover film and the bottom end face are provided with gas circulating holes; the top opening is sealed by the cover film; the cover film and the bottom end face are sealed with the sealing films at the outer surface. An absorbent cotton is arranged at the bottom end face in the cartridge cup. A body of the cartridge cup has a taper. The cross section of the cartridge cup can be round, oval, quadrilateral, polygonal or irregular-shaped. The cartridge structure of the present invention is applicable to a wide array of HNB heating smoking sets, delivering a better compatibility between a cartridge and a heating cavity of each smoking set as well as a higher air tightness therebetween, thus remarkably improving the heating and suction effects of the cartridge.
Patent EP-3859837-A1 (EP)
Inventor: KWON YO HAN
IPC: H01M4/38
Filed: 2019-12-10
Abstract: Provided is a negative electrode active material that includes: an active material core that allows for the intercalation and deintercalation of lithium ions; a plurality of conductive materials positioned on a surface of the active material core; a plurality of organic linkers each including a hydrophobic group and a polar functional group bonded to the hydrophobic group; and an elastic unit, wherein the elastic unit includes: an elastic moiety having two or more binding sites; and a functional group that is bonded to a binding site of the elastic moiety and allowed to react with the polar functional group of the organic linker, and one or more of the plurality of organic linkers are connected to the conductive materials through the hydrophobic groups of the organic linkers, and the polar functional group of the organic linker is bonded to a functional group of the surface of the active material core or to the functional group of the elastic unit.