Patent SG-11201906422V-A (SG)
Title: Apoc-ii mimetic peptides
Inventor: REMALEY ALAN
IPC: C07K14/00
Filed: 2018-01-19
Abstract: C2 - 6 - Delta 5 -o- mono-acyl-Delta 4 -o- Delta 4 -o- Delta 6 -o- bi-acyl-Delta 4 1-1 O co 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit VIII °nolo 1110 01110111110 oimIE (10) International Publication Number WO 2018/136803 Al (51) International Patent Classification: C07K 14/00 (2006.01) A61K 38/00 (2006.01) CO7K 14/435 (2006.01) (21) International Application Number: PCT/US2018/014532 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,358 19 January 2017 (19.01.2017) US 62/476,535 24 March 2017 (24.03.2017) US 62/476,531 24 March 2017 (24.03.2017) US (71) Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPART- METN OF HEALTH & HUMAN SERVICES [US/US]; Office Of Technology Transfer, 6011 Executive Boule- vard, Suite 325, Rockville, MD 20852 (US). CORVIDIA THERAPEUTICS, INC. [US/US]; 35 Gatehouse Drive, Walthamm, MA 02451 (US). (72) Inventors: REMALEY, Alan, Thomas; C/o National In- stitutes Of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852 (US). GHOSH, Soumitra, Shanker; C/o Corvidia Therapeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). DEVALARAJA, Madhav, N.; C/o Corvidia Therapeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). LO, Chih-Hung; C/o Cor- vidia Therapeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). SVIRIDOV, Denis, 0.; C/o National Institutes Of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852 (US). WOLSKA, Anna; C/o National Institutes Of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852 (US). (74) Agent: SUN, Danqiong et al.; Fenwick & West LLP, Sili- con Valley Center, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: APOC-II MIMETIC PEPTIDES - 5 E 0 0.0001 0.001 0.01 0.1 1.0 10 Peptide, uM FIG. 7 (57) : The disclosure provides apolipoprotein C-II (apoC-II) mimetic peptides and methods for treating hypertriglyceridemia in a patient with an effective amount of an apoC-II mimetic peptide. [Continued on next page] WO 2018/136803 Al MIDEDIM011010EIREEM311111111111111111111111110111111111111111111111 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))