baber/WOPTO huggingface dataset:
Patent DE-69316224-D1 (DE)
Inventor: BROWN GEORGE ROBERT
IPC: C07D521/00
Filed: 1993-08-24
Granted: 1998-02-12
Abstract: PCT No. PCT/GB93/01802 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Aug. 25, 1993 PCT Pub. No. WO94/05660 PCT Pub. Date Mar. 17, 1994   <IMAGE>  (I)  Compounds of formula (I) and their pharmaceutically acceptable salts in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1-CR2 is a double bond; X is selected from -CH2CH2-, -CH=CH-, -C 3BOND C-, -CH2O-, -CH2NH-, -NHCH2-, -CH2CO-, -COCH2-, -CH2S- and -SCH2-; Ar1 is a phenylene moiety; Ar2 is a heteroaryl moiety; and wherein one or both of Ar1 and Ar2 may optionally bear one or more substituents independently selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, di-alkylamino, N-alkylcarbamoyl, di-N,N-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, halogeno-alkyl, carboxyalkyl and alkanoylamino; provided that when R1 is hydroxy, X is not selected from -NHCH2- and -SCH2-; are inhibitors of squalene synthase and hence useful in treating medical conditions in which a lowering of cholesterol is beneficial, such as hypercholesterolemia and atherosclerosis. Processes for preparing these derivatives, pharmaceutical compositions containing them are also described together with their use in medicine.
Patent DE-69320428-D1 (DE)
Inventor: SHINOHARA MAHITO
IPC: H04N5/374
Filed: 1993-06-29
Granted: 1998-09-24
Abstract: A solid state image pickup apparatus is constructed by arranging a plurality of photoelectric converting pixels each for accumulating charges produced by receiving a light energy and for amplifying the charges and generating. Timings to start and finish the accumulation of the charges for each pixel in a photoelectric converting section are set to be equal to or slightly deviated from the accumulation timing. For this purpose, the apparatus has: a signal accumulating section in which signal accumulating cells having transistors (21) are arranged; transfer sections 26, 29, and 31 each for transferring the signals of the photoelectric converting pixels as voltages to the control electrodes of the signal accumulating cells; and a reading circuit for outputting the signal from one of the main electrodes of the transistors of the signal accumulating cells. <IMAGE>
Patent DE-69328850-D1 (DE)
Inventor: GOOSSEN JAMES ANDREW BELLEVUE
IPC: G06T11/20
Filed: 1993-07-01
Granted: 2000-07-20
Abstract: A high speed and memory efficient system and method for rendering Bézier curves. The system utilizes a hybrid forward differencing function representing the Bézier curve defined by the Bézier control points and renders the curve with a small number of straight line segments. The system renders the curve in a manner that results in the same Bézier control points that are calculated using the prior art recursive subdivision techniques and rejects line segment approximations that would not be derived from recursive subdivision. The system can start at either end of a Bézier curve and will render the same approximation. The method is readily implemented on a computer and is applicable to Bézier curves of any order. <IMAGE>
Patent DE-69332039-D1 (DE)
Inventor: JOHNSON DOUGLAS GILES
IPC: A23L1/305
Filed: 1993-02-05
Granted: 2002-07-25
Abstract: The present invention provides a nutritionally useful highly concentrated amino acid solution. In an embodiment, the formulation has a broad amino acid profile that is both high in branched chain amino acids and high in overall percent of amino acids. Additionally, the present invention provides a method of selecting the amino acid profile so as to obtain a maximum amino acid concentration. To this end, a stable amino acid solution having a nutritionally appropriate balance of amino acids comprising a total amino acid concentration equal to or greater than 18% (wt/vol) is provided. In an embodiment, an amino acid solution is provided comprising approximately 18 to about 22% branched chain amino acids (wt/wt); and a total amino acid concentration equal to or greater than 18% (wt/vol).
Patent DE-69401965-D1 (DE)
Inventor: COHEN ISSAC
IPC: H02M3/335
Filed: 1994-01-21
Granted: 1997-04-17
Abstract: A switch mode power converter having an overload protection system is disclosed. The system includes an input stage having an input voltage source. A switching circuit for coupling said input source to an output stage is provided. The output stage further includes a first filter circuit providing an output current to a load circuit. A second filter circuit is coupled to the output stage providing a voltage proportional to the output current and to internal temperature of the switch mode converter. An error amplifier responsive to the voltage derived by a second filter and a reference voltage, generates an error signal proportional to the difference of the voltage applied to the error amplifier. The error signal adjusts the operating parameters of the switching circuit. <IMAGE>
Patent DE-69406972-D1 (DE)
Inventor: LEROY JOEL
IPC: A61B17/12
Filed: 1994-04-21
Granted: 1998-01-08
Abstract: The present invention relates to a ligaturing and/or suturing system for endoscopic surgery, characterised in that it comprises in combination: a ligaturing or suturing thread (100) which is mounted slidably in the longitudinal channel of a tubular end-piece (120), and a rigid support (200) comprising a grip handle (210) integral with an elongate rod (220) which is provided, at its proximal end (222) remote from the handle (210), with a receiving cradle (224) which is able to receive, in a movable manner, the tubular end-piece (120), and with a lateral window (228) through which the said cradle (224) opens to the outside of the support (200) in order to permit the passage of the thread (110) in such a way that a traction exerted on the distal end (118) of the latter relative to the support (200) provides for the tightening of the ligature or suture. <IMAGE>
Patent DE-69407112-D1 (DE)
Inventor: DRENTHEN JAN GERT
IPC: G01P5/24
Filed: 1994-08-09
Granted: 1998-01-15
Abstract: The invention relates to a method for determining characteristics of the flow of a medium in a channel by measuring the transit time of sound waves which are transmitted between one or more transducers, and determining the characteristics from the measured transit times. In one embodiment of the method according to the invention, at least two sound waves whose transit time depends on swirl are transmitted along acoustic paths with a different sensitivity to swirl, and a measure of the swirl is determined from the measured transit times. In another embodiment, at least two sound waves whose transit time depends on the symmetry of the flow profile are transmitted along acoustic paths with a different sensitivity to symmetry, and a measure of the symmetry is determined from the measured transit times. These embodiments are preferably combined. If weighting factors are allocated to the values obtained, the individual velocities of the sound waves can be used to calculate the average flow velocity and/or the throughput of the medium. Since allowance is made for possible disturbances of the velocity profile, the accuracy of the calculated variables is good. The invention also provides for a device, by means of which the method according to the invention can be carried out. <IMAGE>
Patent DE-69410492-D1 (DE)
Inventor: PETTIT GEORGE R
IPC: C12P17/18
Filed: 1994-01-19
Granted: 1998-07-02
Abstract: An Eastern Indian Ocean marine sponge in the genus Spongia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1. The new perhydropyran-containing structure, as shown below, was found to be remarkably potent and specific, log molar TCI50 to < -10, against twenty human cancer cell lines in the U.S. National Cancer Institute's panel of sixty. <CHEM>
Patent DE-69411891-D1 (DE)
Inventor: DE VOS MARIE-JOELLE
IPC: C12Q1/6816
Filed: 1994-02-18
Granted: 1998-08-27
Abstract: PCT No. PCT/BE94/00013 Sec. 371 Date Aug. 21, 1995 Sec. 102(e) Date Aug. 21, 1995 PCT Filed Feb. 18, 1994 PCT Pub. No. WO94/19364 PCT Pub. Date Sep. 1, 1994The probe comprises: a) an oligonucleotide or oligodeoxyribonucleotide part constituted by a DNA or RNA nucleic acid sequence S, depending on the type of molecule to be detected, and b) a non-nucleotide part possessing chemical properties enabling direct or indirect atttachment of one or more detection units or marking elements M detectable non-isotopically by production of colour or light. The probe is characterized by the fact that part b) is constituted by a chain of phosphate units interspersed with alkyl groups, viz.: b1) certain alkyl groups uniting the different phosphate groups and presenting no special functionality b2) alkyl groups presenting primary amine groups which allow splicing with varied reagents to carry out direct or indirect detection, the b2) groups being bonded to part a) or sequence S by way of groups b1). Sequence S is bonded at its 5' and/or 3' extremity to one or more marking elements M. The probes of this type are used to detect and diagnose hereditary genetic diseases, oncogenes, viral, bacterial or parasitic diseases.
Patent DE-69412041-D1 (DE)
Inventor: PARODI FABRIZIO
IPC: C08G18/58
Filed: 1994-11-03
Granted: 1998-09-03
Abstract: Crosslinkable liquid composition based on organic isocyanates and epoxy compounds, comprising the following components:     (A) an organic polyisocyanate; (B) a polyepoxide or mixture of a polyepoxide and a monoepoxide; and   (C) a catalyst constituted by at least one cyanoderivative containing a quaternary nitrogen atom, which composition can be polymerized at temperatures of 40 DEG C or higher, by a process comprising exposure thereof to a non-ionizing electromagnetic radiation having a frequency comprised in the microwave range of frequencies, to obtain a solid material endowed with an excellent combination of physical, chemical and mechanical properties.
Patent DE-69412800-D1 (DE)
Inventor: BUGLER THOMAS W
IPC: F28F25/02
Filed: 1994-03-14
Granted: 1998-10-01
Abstract: A multi-level film fill industrial size water cooling tower is disclosed having upper and lower film fill packs arranged one above the other, and wherein a self-balancing hot water distribution system is provided for directing flows of hot water from the main supply line to respective distributors which are proportional to flow of hot water in the main supply line. Laterally extending distribution pipes connected to the main supply line in overlying relationship to the film fill packs have restrictor nozzles thereon all located in a common horizontal plane, so that the flow of hot water from all of the nozzles remains proportional to the flow in the main supply line. Each of the restrictor nozzles is vented to the surrounding atmosphere to prevent creation of significant negative pressure on the hot water flowing from each nozzle.
Patent DE-69431964-D1 (DE)
Inventor: KIKINIS DAN
IPC: H04M1/72415
Filed: 1994-10-28
Granted: 2003-02-06
Abstract: A digital assistant module which interfaces with a host computer, comprises an on-board CPU which manages functions of the digital assistant module, a memory connected to the CPU that stores data and executable routines; a user-operable input apparatus, a Personal Computer Memory Card International Association (PCMCIA) host interface adapted so as to provide communications between the digital assistant module and the host computer upon docking with the host computer; and an enclosure that houses said CPU, said memory, said input apparatus, and said host interface, said enclosure having a form factor which is PCMCIA standard Type II or Type III. <IMAGE>   <IMAGE>
Patent DE-69432439-D1 (DE)
Inventor: COOKSON CHRISTOPHER J
IPC: G11B27/00
Filed: 1994-10-13
Granted: 2003-05-08
Abstract: An optical disk (23) containing PG-rated and R-rated versions of the same motion picture. To minimize redundant storage of data, three types of video data blocks are provided in the same track, in an interleaved fashion - A-type blocks which contain material unique to version A, B-type blocks which contain material unique to version B, and C-type blocks which contain material common to both. A series of codes and pointers included in each block allow play of all common blocks, over the blocks which contain data unique to the unselected version. Play of adult-rated versions are automatically prevented if a parental lock option in the player has been keyed on. The disk may contain special software for identifying multiple versions of the same material where the selection criterion is one other than a rating.
Patent DE-69433823-D1 (DE)
Inventor: SEKELLICK MARGARET J
IPC: C12N15/20
Filed: 1994-10-21
Granted: 2004-07-08
Abstract: The present invention relates to a chicken interferon gene coding for the amino acid sequence of SEQ ID NO: 1. The present invention also relates to a method of producing biologically active chicken interferon recombinantly, a method of isolating other non-mammalian interferon genes, a method of making a transgenic fowl having the chicken interferon gene incorporated therein, and method for delivery of the chicken interferon in the bird, such as by genetic immunization or aerosol. Expression of the chicken IFN gene yields functional chicken interferon.
Patent DE-69500468-D1 (DE)
Inventor: KOLLERUP IB
IPC: A61F5/445
Filed: 1995-03-10
Granted: 1997-09-04
Abstract: PCT No. PCT/DK95/00114 Sec. 371 Date Sep. 24, 1996 Sec. 102(e) Date Sep. 24, 1996 PCT Filed Mar. 10, 1995 PCT Pub. No. WO95/24169 PCT Pub. Date Sep. 14, 1995An ostomy appliance is a convex product where a layer of adhesive is present to the convex side of the product. The adhesive is present on a thermoplastic carrier sheet disposed between the adhesive and a ring-shaped body having a convex proximal side, and the carrier sheet is attached, e.g. by welding, to the ring-shaped body along the inner periphery and the outer periphery thereof. At its peripheral, plane part, the appliance has a plane layer of a thermostable material, such as paper, in close connection with the adhesive. The thermostable material extends radially outside the outer periphery of the ring-shaped body and provides stability during thermoforming.
Patent DE-69503129-D1 (DE)
Inventor: HAWKINS MARY
IPC: C07H19/167
Filed: 1995-04-25
Granted: 1998-07-30
Abstract: The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.
Patent DE-69511220-D1 (DE)
Inventor: PIROTTA GIAMPIERO
IPC: B29C69/00
Filed: 1995-11-23
Granted: 1999-09-09
Abstract: Process for the production of thermoinsulating structural elements, which includes:   a) producing by thermoforming a cell (3) made of thermoplastic material;   b) pulling on such cell on a male die half shell (1); c) closing the die with a negative half shell (2) suitable to form a cavity between the half shell (2) and the cell (3),   d) inserting in the cavity bored hollow elements (4) e) filling the cavity with foamed pearls (8) in thermoplastic polymers; f) sintering the pearls with steam fed through hollow elements (4);    g) cooling and extracting the hollow elements (4) h) extracting the structural element from the die.
Patent DE-69513183-D1 (DE)
Inventor: FOWLER TIMOTHY
IPC: A61K8/40
Filed: 1995-08-16
Granted: 1999-12-09
Abstract: The present invention relates to nonabrasive thickened aqueous-based personal cleansing compositions. These compositions utilize insoluble micronized cleansing particles of defined particle size that are not tactilely perceived by the user during the cleansing process, and yet which provide improved cleansing performance from the composition.
Patent DE-69514956-D1 (DE)
Inventor: MERONI UMBERTO
IPC: B22D11/10
Filed: 1995-05-08
Granted: 2000-03-16
Abstract: Discharge nozzle (10) for continuous casting of slabs having narrow sides between about 30 and about 300 mm. wide, which is employed to distribute liquid metal in a continuous casting mould and is of a type comprising a substantially vertical discharge pipe (11), which is closed at its lower end and includes lateral terminal discharge holes (14) facing towards the narrow sides of the mould and cooperating with means (13) that distribute and deflect the flow of liquid metal, the discharge pipe (11) comprising a first segment (11a) having a downwardly converging circular cross-section and a second downwardly diverging segment (11b) with a cross-section which can be varied progressively from circular to substantially rectangular at least with rounded short sides, the distribution and deflection means (13) consisting of two distribution chambers (15), one per each lateral discharge hole (14), the chambers (15) being open at their upper (16a) and lower (16b) portions and being defined by a sidewall (17) which, at the opposite side of the lateral discharge hole (14), is conformed as a downwardly diverging deflector (18) forming an angle " alpha " with the vertical between 10 DEG  and 35 DEG , the lateral discharge holes (14) being adjacent to a bottom end wall (12) and having an overall section about equal to the section of the outlet of the second segment (11b) of the discharge pipe (11), each distribution chamber (15) defining an upper discharge outlet (16a) and a lower discharge outlet (16b). <IMAGE>
Patent DE-69515418-D1 (DE)
Inventor: STORY PHILLIP M
IPC: B01J2/00
Filed: 1995-11-09
Granted: 2000-04-13
Abstract: A milled powder is produced applying an electrostatic charge to the powder before milling by flowing a milling fluid through a charge generator. Also claimed is a method of producing a milled powder by directly imparting an electrostatic charge to the powder.
Patent DE-69534296-D1 (DE)
Inventor: SELBY MARK
IPC: A61K39/00
Filed: 1995-07-26
Granted: 2005-08-18
Abstract: Novel Hepatitis C E1 and E2 truncated polypeptides and complexes comprising these polypeptides are disclosed. The polypeptides are C-termally truncated to remove all or a portion of their membrane spanning domains. Hence, the polypeptides are capable of secretion when expressed recombinantly.
Patent DE-69535645-D1 (DE)
Inventor: CHERIF-CHEIKH ROLAND
IPC: A61K38/31
Filed: 1995-08-31
Granted: 2007-12-27
Abstract: This invention relates to the parenteral administration of solid drug compositions. In particular, this invention relates to a syringe-like device for delivering solid drug cylinders including a syringe barrel, a needle, and a microplunger and piston assembly, wherein said microplunger pushes said solid drug cylinder out of said needle and into a patient and said piston pushes on said microplunger. <IMAGE>
Patent DE-69605431-D1 (DE)
Inventor: HUCKNALL HAYDON
IPC: G07F11/58
Filed: 1996-08-23
Granted: 2000-01-05
Abstract: PCT No. PCT/GB96/02051 Sec. 371 Date Feb. 23, 1998 Sec. 102(e) Date Feb. 23, 1998 PCT Filed Aug. 23, 1996 PCT Pub. No. WO97/08667 PCT Pub. Date Mar. 6, 1997Dispensing apparatus for dispensing individual articles (50) at a dispensing station (A) from a line of the articles stored one-behind-another on a trackway (10) comprises a conveyor belt (16) on which the articles rest. Belt (16) is connected at one end to variable force springs (19) beneath the trackway (10) and at its other end to a follower or pusher plate (13). When the springs (19) are tensioned by moving the plate (13) away from the dispensing station to load the device the conveyor (16) exerts traction on the articles stored thereon tending to move them toward stop means (20,34) at the dispensing station. When an article (51) is removed from the dispensing station (A) the conveyor (16) moves up the remainder so that a next article is positioned at the dispensing station (A) against the stop means (20,34). Ramps (22) at the dispensing station project the article thereat from the dispense to facilitate its removal. In one embodiment the trackway (10) and conveyor (16) are incorporated in a cassette (28) one end wall (34) of which constitutes the stop means. The ramps (22) are positioned opposite a slot (35) in the cassette adjacent this end wall (34) so as to project an article at the dispensing station (A) from the cassette. In another embodiment two conveyor means (16,16A) are provided, articles being located in openings (37) therefore along one of the conveyors (16A) and resting upon the other conveyor (16).
Patent DE-69607910-D1 (DE)
Inventor: SOEDERGARD BENGT
IPC: E03F/
Filed: 1996-09-25
Granted: 2000-05-31
Abstract: The pumping station (1) with sewage inlet (4) comprises a vertical circular shaft (2) steeply sloped (16) at the bottom to a narrow sump (3) which is wide enough to accommodate two side by side submersible pumps (6) with inlets (7). Each pump is mounted by a pivoting bracket (9) on a guide (14) for lifting and maintenance. The pump outlet flange (8) is sealed against a connection unit (1) by a wedging lug on the bracket (9). The unit (13) is mounted on the sloping side (16) and connected to the discharge pipe(5). All projecting surfaces are steeply sloped and faired to eliminate trapping of sludge or larger material.
Patent DE-69610939-D1 (DE)
Inventor: CHMIEL OLIVER
IPC: A23L27/60
Filed: 1996-03-27
Granted: 2000-12-21
Abstract: Interesterification of phospholipids with triglycerides comprises using a combination of an immobilised lipase and an immobilised phospholipase in the absence of solvent.
Patent DE-69628588-D1 (DE)
Inventor: HODGES MCINDOE
IPC: G01N27/42
Filed: 1996-11-15
Granted: 2003-07-10
Abstract: An electrochemical sensor is described for determination of glucose in a liquid blood sample. This comprises a first sheet (14) having a palladium sputter coating, as well as a second sheet (15) having a palladium sputter coating and a third sheet of electrically resistive material having an aperture (11) extending through the third sheet and defining a side wall of the cell. The space between the first sheet and the second sheet comprises a capillary space. A ferricyanide mediator is supported on one of the coatings. Access to the cell is provided at the side edge of the cell where notches (16) extending through the first sheet, second sheet, and third sheet intersect cell (11). A liquid blood sample in contact with a notch is spontaneously drawn by capillary action into the electrochemical cell. <IMAGE>
Patent DE-69629893-D1 (DE)
Inventor: ROBINSON JAMES W
IPC: B25C5/00
Filed: 1996-11-19
Granted: 2003-10-16
Abstract: A fuel system is provided for a combustion-powered tool (10) having a self-contained internal combustion power source (16) with a combustion chamber (62), and constructed and arranged for driving a drive blade (88) to impact a fastener (N) and drive it into a workpiece. The tool (10) includes a housing (12) having a main chamber (14) enclosing the power source (16) and having a first end (28) adjacent a nosepiece (76) wherein the fasteners (N) are positioned prior to driving, and a second end (34) opposite the first end (28) and adjacent the combustion chamber (62). A fuel cell chamber (18) is in communication with the main chamber (14) and has a first chamber end (28) corresponding to the first end (28) of the main chamber (14) and a second chamber end (40) corresponding to the second end (34) of the main chamber (14). A fuel metering valve (44) is disposed in the fuel cell chamber (18) at the first end (38) so that a fuel cell (50) having a fuel outlet end (52) operationally inserted into the fuel cell chamber (18) will engage the valve (44) so that fuel is dispensed into the valve in a location closer to the first chamber end (38) than to the second chamber end (40). <IMAGE>