Patent SG-11201805420S-A (SG)
Title: Antibodies and conjugates thereof
Inventor: PERLROTH D
IPC: A61P27/02
Filed: 2016-12-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111011101011101111110011111111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/117464 Al 6 July 2017 (06.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: ALTMAN, Daniel, E.; Knobbe, Martens, Olson & A61K 39/00 (2006.01) A61K 47/48 (2006.01) Bear, LLP, 2040 Mainstreets 14th Floor, Irvine, California A61K 39/44 (2006.01) A61P 27/02 (2006.01) 92614 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2016/069336 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, 29 December 2016 (29.12.2016) DO, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/273,177 30 December 2015 (30.12.2015) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: KODIAK SCIENCES INC. [US/US]; 2631 ZA, ZM, ZW. Hanover Street, Palo Alto, California 94304 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: PERLROTH, D., Victor; c/o Kodiak Sciences kind of regional protection available): ARIPO (BW, GH, Inc., 2631 Hanover Street, Palo Alto, California 94304 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (US). TO, Wah, Yuen; c/o Kodiak Sciences Inc., 2631 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Hanover Street, Palo Alto, California 94304 (US). LI- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, ANG, Hong; c/o Kodiak Sciences Inc., 2631 Hanover DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = Street, Palo Alto, California 94304 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] — = (54) Title: ANTIBODIES AND CONJUGATES THEREOF (57) : Provided herein are anti-VEGF-A antibodies = = Effect of Various anti-VEGF Molecules on Binding of biotin-VEGF to Plate and antibody conjugates thereof. Some embodiments of the bound VEGFR EDC-Fc Protein antibodies can be conjugated to a moiety, such as a HEMA- PC polymer. Some the antibody conjugates embodiments of = - = Effect of anti-VEGF Molecules on can retain or enhance antibody activity. The antibody and Biotin-VEGF Binding to VEGFR conjugate thereof can be particularly useful for treating dia- = - 2.0 betic retinopathy. Further provided are methods for conjuga- _ = 4- 0G1950 tion of a polymer to a protein such as an antibody, such as • 0G1953 IgG1. _ 1.5- * Lucentis = = g 0 Lo Tr 1.0- o ° , -v- Avastin 4 - a-VEGF BC e oc-VEGF = = = 0.5- .. - = 0.0 -1 0 1 2 3 4 — _ = Concentration (Log-nM) 11 Agent ;50 001950 (nM) 3.612 001953 4.085 7r Lucents 9.262 Avastin 10.420 7r a-VEGF BC 8.129 I...' a-VEGF 7.236 11 1-1 FIG. 20 IN 1-1 0 ei O WO 2017/117464 Al 1#11101M01101DEIROIDEOM01010110111100M11VOIS SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))