baber/WOPTO huggingface dataset:
Patent DK-599388-D0 (DK)
Inventor: KOGEN HIROSHI
IPC: C07C251/32
Filed: 1988-10-27
Abstract: Compounds of formula (I): <CHEM> [in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y represents hydrogen, or an aryl, cycloalkyl or heterocyclic group] have valuable antihypercholesteremic activities and may be used in the treatment of disorders arising from a blood cholesterol imbalance in humans and other animals. They may be prepared by introducing the group =NO-A-Y in place of an oxygen atom at the 4-position or introducing the group -O-CO-X in place of a hydroxy group at the 1-position in a corresponding compound in which the hydroxy group at the 16 position is protected and deprotecting that group.
Patent DK-606786-D0 (DK)
Inventor: WILLIAMS CHARLES E
IPC: E06B3/94
Filed: 1986-12-16
Abstract: An accordian type folding door of the type disclosed in Holloway U.S. Patent 3,223,147 in which each cover of the door is in the form of consecutive cover sections, connected to the door lazytongs (26u, 26l) in side by side relation, each of which cover sections defines a fold or pleat of the door and includes a pair of relatively wide slats (33) of substantially equal width disposed on either side of a relative narrow slat (34), with such slats being pivoted together by inner and outer flexible sheets (55, 56) that are respectively adhered to the opposite faces of the respective slats; for each cover section of the door covers, the flexible sheets extend beyond the relatively wide slats thereof to define sheet end (100, 102, 104, 106), with such sheet end portions of adjacent cover sections being clamped together by a spline (110) that extends the height of the cover that the cover sections define. Each pleat or fold of the respective door covers thus extends between separate of such splines with each spline being verti­cally disposed and pivotally connected to the door upper and lower lazytongs (26u, 26l) for door closing and opening movement of the door covers with the door lazytongs.
Patent HU-911986-D0 (HU)
Title: Process for the production of cyclical amido-derivatives and the medical preparations containing them
Inventor: SUGIMOTO HACHIRO
IPC: C07D498/04
Filed: 1991-06-14
Abstract: The cyclic amide derivative is defined by the formula (I) or a  salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is <CHEM> R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.
Patent HU-902757-D0 (HU)
Title: Cutting device provided with at least two cutting edges
Inventor: SCHIEFELE GEORG
IPC: B28B/
Filed: 1990-04-05
Abstract: The cutting device has two cutter components. It is  especially suitable for split plain tiles. The cutter carriers (25) may be pivoted into their inoperative and operative positions. Each cutter (25) is connected to a spindle (29, 30), the spindles being arranged coaxially (40) one within the other. Thus the cutter carriers pivot about the same axis (40) at the same time in the manner of scissors. The cutter carriers (25) are forked and the cutters (26) are in the form of wires and interchangeable. This cutting device is permanently installed on the extruding press belt. It is nevertheless easy to regulate, can be monitored and operates reliably.
Patent HU-913434-D0 (HU)
Title: Granulate preparation with propanyl content
Inventor: HOUGHTON RICHARD DAVID
IPC: A01N37/18
Filed: 1991-10-31
Abstract: A dispersable granular formulation has been developed which contains at least 60% propanil herbicide. This formulation also provides excellent suspensibility and dispersibility characteristics and resists attrition.
Patent HU-913453-D0 (HU)
Title: Fungicide preparation
Inventor: KUENG RUTH
IPC: A01N43/84
Filed: 1991-11-01
Abstract: Fungicidal compsns. contg. (a) RH-7592 or its acid-addn. salts or metal complexes and (b) fenpropidine or its acid-addn. salts are new. RH-7592 is 4-(4-chlorophenyl)-2-phenyl-2-(1H-1,2,4-traixol-1- ylmethyl)-butyronitrile (I) and is described in EP251775. Fenpropidine is 1-(3-(4-t-butylphenyl)-2-methylpropyl)-piperidine (II) and is described in DE2752135.
Patent HU-905486-D0 (HU)
Title: Process for producing pharmaceutical preparatives containing heteroaryl-3-oxo-propane-nitrile derivatives being applicable for stimulating development of medulla
Inventor: DORIA GIANFEDERICO
IPC: C07D495/04
Filed: 1990-07-11
Abstract: PCT No. PCT/EP90/01129 Sec. 371 Date Mar. 12, 1991 Sec. 102(e) Date Mar. 12, 1991 PCT Filed Jul. 11, 1990 PCT Pub. No. WO91/01309 PCT Pub. Date Feb. 7, 1991.Heteroaryl-3-oxo-propanenitrile derivatives of formula (I)   <IMAGE> (I)  wherein X represents an oxygen atom or a -CH(R4)-, -O-CH(R4)-,-S(O)n-, -S(O)n-CH(R4)-, -CH(R4)-O-, -CH(R4)-S(O)n- or -CH(R4)-CH2- group wherein n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as herein defined; and Q is hydrogen, carboxy, C2-C7- alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in stimulating myelopoiesis in bone marrow suppressed mammals.
Patent HU-908125-D0 (HU)
Title: Building stone with longitudal large holes
IPC: E04B2/14
Filed: 1990-12-07
Abstract: A perforated brick (1) possesses vertical through cavities (2) which are arranged, in plan view, in a plurality of rows (3) running next to one another. The sound-insulating property can be increased to a surprisingly high degree while retaining a constant heat-insulating property and load-carrying capacity, if the ratio of the maximum cavity length (L), measured in the direction of the row (3), to the minimum distance (D) between two adjacent cavities (2) belonging to two different rows (3) is 1:1 to 6:1, and the sum of the minimum distances (X), measured in the direction of the row (3), of the cavities (2) of a row (3) from one another and from the brick edge is 12% to 18% of the brick width (B) extending in the direction of the rows (3). <IMAGE>
Patent NO-870483-D0 (NO)
Inventor: CROSS PETER EDWARD
IPC: C07D213/74
Filed: 1987-02-06
Abstract: A compound of the formula: 
<CHEM>
 or a pharmaceutically acceptable salt thereof, wherein <<Het>> is selected from (a) a 3- or 4-pyridinyl group optionally substituted by one or two substituents each independently selected from C1-C4 alkyl and amino, (b) a 2-pyridinyl group substituted by an amino group, (c) a 2-imidazolyl group optionally substituted by one or two C1-C4 alkyl groups and (d) a 2-, 3- or 4-pyridinyl group substituted by a nitro group, or an N-oxide thereof, or a 2-, 3- or 4-pyridinyl group substituted by a group of the formula -NHCOO(C1-C4 alkyl);
 R is selected from (a) -NHSO2R<3> where R<3> is C1-C4 alkyl, C3-C7 cycloalkyl or -NR<1>R<2> where R<1> and R<2> are each independently M or C1-C4 alkyl, (b) -SO2NR<1>R<2>where R<1> and R<2> are as defined above, (c) nitro, (d) amino and (e) acetamido;
 and X is a group of the formula -(CH2)m- where m is an integer of from 1 to 4, -CO(CH2)n- or -CH(OH)(CH2)n- where n is 1, 2 or 3.
Patent NO-872372-D0 (NO)
Inventor: TOMCZUK BRUCE EDWARD
IPC: C07D409/12
Filed: 1987-06-05
Abstract: Imidazoheterocyclic compounds having the formula: <CHEM> wherein A is a pyridine ring in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity and find use as muscle relaxants, anticonvulsants and antianxiety agents.
Patent NO-894013-D0 (NO)
Inventor: BEY PHILIPPE
IPC: A61K38/00
Filed: 1989-10-06
Abstract: This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by a substituted malonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula <CHEM> the hydrates, isosteres or the pharmaceutically acceptable salts thereof wherein X is <CHEM> R1 is hydrogen, an amino protecting group selected from Group K, an alpha -amino acid or a peptide comprised of a number of  alpha -amino acid building blocks, said  alpha -amino acid or peptide optionally bearing on its terminal nitrogen atom an amino protecting group selected from Group K, R2 is the "R group" residue of the  alpha -amino acid responsible for directing the inhibitor to the active site of the enzyme or is -A-SiR7R8R9, C1-10 alkyl, aralkyl or aryl with R7, R8 and R9, each being selected from C1-10, alkyl, aralkyl or aryl and A is a C1-6 alkylene, R4 is the specific R-group residue of the  alpha -amino acid for that peptidase substrate analog, R5 is an  alpha -amino acid or peptide comprised of  alpha -amino acids or is deleted,  Y is NHR3 or OR3 with R3 being H, C1-7 alkyl, benzyl or phenethyl. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
Patent NO-900801-D0 (NO)
Inventor: STEDMAN IAN G
IPC: C25C3/00
Filed: 1990-02-20
Abstract: An aluminium smelting cell comprising a cathode having an active upper surface (30), a plurality of anodes (50) each having a lower surface (60) spaced from the upper surface (30) of the cathode, said cathode upper surface being sloped at an acute angle in a primary or longitudinal direction of each anode, and being formed with pairs (31),(32) of oppositely sloped surfaces extending in a transverse or secondary direction under each anode to cause complementary shaping of the lower anode surfaces to reduce the migration of bubbles between the anode and cathode along the anode surfaces in said primary or longitudinal direction to thereby reduce the path length of said bubbles whereby the turbulence caused by coalesced bubble disengagement from the bath electrolyte is significantly reduced while maintaining adequate bath circulation between the anode and cathode.
Patent NO-902635-D0 (NO)
Inventor: CARNEL ALAIN
IPC: G01R21/00
Filed: 1990-06-13
Abstract: The invention relates to an input circuit for an electrical energy meter, which circuit has a current path and a voltage path, the current path being associated with a mutual conductance transformer. In order to compensate for the differentiating function of the transformer, but without introduicng interference signals, the current path includes an active filter connected as an integrator and provided with a coupling capacitance suitable for blocking low frequency signals.
Patent NO-904963-D0 (NO)
Inventor: LEFEVRE DIDIER
IPC: C12Q1/06
Filed: 1990-11-15
Abstract: The present invention relates to a reagent and to a method of using the same for automatically determining at least one leukocyte sub-population from a total blood sample. Using this reagent, it is possible, in a single step, to lyse the erythrocytes through the action of saponin and SDS, as well as to ensure the differential staining of the leukocyte sub-populations, at the same time preserving the integrity and morphology of the cells, through the combined action of various components including chlorazol black, an alcohol, a surfactant and preserving agents. The reagent according to the invention can be applied to different types of automatic flow cytometry analyzers.
Patent NO-910644-D0 (NO)
Inventor: HUNZIKER HANS
IPC: E06B3/30
Filed: 1991-02-18
Abstract: The invention relates to a wood/metal frame for windows, doors or the like, in which a one-part metal frame (3) is snapped on on the weather side. The invention is seen in that the snap web (13) extends over the supporting surface (5) of the wooden frame to below the plate-shaped element (6), engages, by means of a web edge (11) angled outwards in a hook-shaped manner, into a groove (23) arranged in the supporting surface (5) and extending in the longitudinal direction of the profile, and is supported on the supporting surface via a bearing leg (10) which is articulated in the region of the web edge (11) and which, on the weather side, merges at right angles into a locking leg (15) which is parallel to the wooden-frame bearing surface (19) and which engages in a locking manner behind the outer drip edge (22) of the latter by means of an edge (15a) bent in a hook-shaped manner towards the room interior. <IMAGE>
Patent NO-915049-D0 (NO)
Inventor: SAINSBURY MALCOLM
IPC: A61P25/00
Filed: 1991-12-20
Abstract: Compounds of the formula <CHEM>  wherein R is hydrogen or a lower alkyl group or COR<1><5> R<1>, R<2>, R<1><1> and R<1><2>, are hydrogen or a lower alkyl group, R<3>, R<4>, R<5> and R<6> are hydrogen, hydroxy, halogen, a lower alkyl group, a lower alkoxy group or a mono- or di-lower alkyl amino group, NH2 or NR<1><3>COR<1><4>, R<7>, R<8>, R<9> and R<1><0> are hydrogen, hydroxy, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkylamino group, or NH<1><3>COR<1><4> wherein R<1><3>, R<1><4> and R<1><5> are hydrogen or a lower alkyl group, enantiomers and salts thereof, with the proviso that when R is COR<1><5> then at least one of R<3> to R<1><0> are hydroxy or a mono or di-lower alkylamino group, are useful as antioxidants, within the medical and non-medical field. Many of the compounds of formula IA and IB are new and various methods for preparing them are described.
Patent NO-924001-D0 (NO)
Inventor: STANEK JAROSLAV
IPC: C07C309/35
Filed: 1992-10-15
Abstract: The invention relates to acid addition salts of bases of the formula I <IMAGE> in which A, R1, R2, R3, R4, R5, X and Z have the meanings given in the description, with an acid [PA], which denotes a mono- or polybasic acid selected from carbonic acid, alkanoic acids which are unsubstituted or monosubstituted to polysubstituted, apart from formic acid, unsubstituted acetic acid, lysine and arginine; alkenoic acids which are unsubstituted or substituted, apart from unsubstituted fumaric acid, cycloalkylcarboxylic acids, arylcarboxylic acids, aryl-lower alkylcarboxylic acids in which lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkanesulphonic acids which are unsubstituted or substituted, apart from unsubstituted methanesulphonic acid, aromatic sulphonic acids, alkylsulphuric acids, N-substituted sulphamic acids, organic acids without carboxyl, sulpho, sulphate or phospho groups, and further from pyrophosphoric acid and hydrogen iodide; and tautomers thereof. The acid addition salts are employed for the treatment of disorders which respond to inhibition of S-adenosylmethionine decarboxylase.
Patent NO-924810-D0 (NO)
Inventor: CALVERT JOHN RICHARD
IPC: A61M15/00
Filed: 1992-12-11
Abstract: An inhaler for inhaling pulverulent medicament from within a capsule comprises a chamber 24 within which the capsule is free to rotate while having its longitudinal axis in the median plane of the chamber and thus generally parallel to the front and rear walls 29 and 30 of the chamber, by virtue of the fact that the spacing between said front and rear walls is less than the axial length of the capsule but just greater than the diameter of the capsule. The device includes pins 21 serving as opening means to pierce the ends of the capsule while it is seated in a recess 25, whereupon the retraction of the pins 21 allows the capsule to be entrained into swirling airflow in the chamber 24 during inhalation of air through air inlets 26 and out through a mouthpiece nozzle 27. <IMAGE>   <IMAGE>
Patent NO-933590-D0 (NO)
Inventor: ENGEL JUERGEN
IPC: A61P15/00
Filed: 1993-10-07
Abstract: Storage-stable mesna injection solutions with a pH above 7.5 and a preparation process are described.
Patent NO-941431-D0 (NO)
Inventor: GRUERE YVES
IPC: G05B19/048
Filed: 1994-04-20
Abstract: Microprocessor safety system, applicable in particular to the field of railway transportation, for monitoring and controlling actuators (ACT) as a function of the data provided by sensors (CP), characterised in that it comprises at least two paralleled microprocessors (P1, P2) handling the same application, the inputs of which receive the, previously coded, data (DE) from the sensors (CP) and whose output data are reread in safety so as to be compared with the input data, and a third, comparison, microprocessor (P3) called a poller, for comparing, through software and in safety, the coded characteristic results (R1, R2) from the two application microprocessors (P1, P2) and controlling accordingly a dynamic monitor (CD) authorising the sending of the output data (DS) to the actuators (ACT). <IMAGE>
Patent NO-944049-D0 (NO)
Inventor: WHEELER ROGER D
IPC: B05B15/00
Filed: 1994-10-24
Abstract: The cover is formed into two halves which enclose opposite sides of the gun. A tab on the front of each cover half is retained in a notch in the gun. Rear ends of the cover halves are releasable secured together by a first spring clip positioned in aligned grooves in the cover halves. Ends of the cover halves which extend over a gun handle are releasably secured together by a second spring clip positioned in aligned grooves in the cover halves.
Patent NO-944114-D0 (NO)
Inventor: BSCHORR OSKAR
IPC: G10K11/172
Filed: 1994-10-28
Abstract: The vibration absorber for damping structural sound has a waveguide made of mass-spring elements arranged one above another in layers in the wave propagation direction. The mass-spring elements are designed as bending beams or bending plates having a spring stiffness which decreases in the wave propagation direction and which are connected to one another in a force-transmitting and/or torque-transmitting manner via spacers arranged offset from one another in such a manner that when pressure or tension is applied to these mass-spring elements, bending occurs within at least one mass-spring element. <IMAGE>
Patent NO-944156-D0 (NO)
Inventor: BRUGGER STEPHAN
IPC: A61M11/06
Filed: 1994-11-01
Abstract: The invention relates to a device for atomising, distributing and mixing liquid or pulverulent substances by means of a stream of compressed gas, and it is particularly intended for the production of aerosols for inhalation purposes. A nozzle head (5) working on the Venturi principle is used to produce an aerosol from material to be atomised and stored in a container (1). An extended deflector shield (4) is provided at the level of the opening of the nozzle head and at the lower end of a chimney (3) for the supply of air. In order to form a labyrinth guide there is a cylindrical insert (7) which establishes an annular gap around the chimney (3). The proportion of aerosol particles (diameter about 0.5 to 5  mu m) that can reach the lungs is considerably increased by the extension of the deflector shield. <IMAGE>
Patent NO-950799-D0 (NO)
Inventor: GIBSON LOWELL LEE
IPC: A61K31/455
Filed: 1995-03-01
Abstract: This invention provides orally administerable pharmaceutical formulations comprising raloxifene, its ethers or esters, or a pharmaceutically-acceptable salt thereof, in combination with a hydrophilic carrier composition.
Patent NO-951235-D0 (NO)
Inventor: REZAI EBRAHIM
IPC: A61F13/53
Filed: 1995-03-30
Abstract: A method and apparatus (1) for making a cohesive sheet from particulate substantially water insoluble, absorbent hydrogel-forming polymer materials. The method comprises the steps of continuously layering dry absorbent gelling particles onto a conveyor. The particles are then sprayed with a liquid mixture, which is a solution of water and a cross-linking agent for the polymers in the particulate material. The amount sprayed is sufficient to cause effective surface cross-linking of the particulate material after the sheet is cured. The layering and spraying steps can then be repeated a number of times if desired. Pressure is then applied to the particulate material by passing it through a pair of compaction rolls. The apparatus (1) comprises a conveyor (3), one or more feeders (5) for layering the dry absorbent gelling particles onto the conveyor, one or more sprayers (4) for spraying the particles on the conveyor with the liquid mixture and a pair of compaction rolls (6).
Patent NO-952579-D0 (NO)
Inventor: CAUBERE PAUL
IPC: A61K31/40
Filed: 1995-06-27
Abstract: (Thia)cycloalkyl(b)indole derivs. of formula (I), their optical isomers and acid or base addn. salts, are new. R1 = Ar-(CH2)n-O-; n = 0, 1-4; Ar = phenyl, naphthyl, thienyl, furyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, thiadiazole, oxadiazole, pyridyl, quinolyl, isoquinolyl, indolyl, benzofuryl, or benzothienyl (opt. substd. by one or more halo, alkyl, alkoxy, hydroxy or CF3); R2 = H, halo, alkyl, alkoxy or CF3; R3 = H, alkyl, carboxyalkyl or alkoxycarbonylalkyl; A = -(CH2)m- or a gp. of formula (i); m = 3-6; p = 1-4; alkyl, alkoxy = 1-6C.
Patent NO-954281-D0 (NO)
Inventor: ENGELHARD ROLF
IPC: A61L2/10
Filed: 1995-10-26
Abstract: Water to be purified swirls about a source of ultraviolet radiation to kill any microorganisms contained therein and flows through a carbon filter cartridge mounted about the ultraviolet source to remove any chlorine and particulate matter. The outflow from the carbon filter is again subjected to ultraviolet radiation to kill any microorganisms entrained in the water emanating from the carbon filter. An ozone generator may be incorporated to entrain ozone with the inflowing water to enhance killing of any microorganisms present and to oxidize any undesirable compounds.
Patent NO-955328-D0 (NO)
Inventor: TANIKAWA KEIZO
IPC: C07D237/22
Filed: 1995-12-28
Abstract: PCT No. PCT/JP94/01015 Sec. 371 Date Mar. 22, 1996 Sec. 102(e) Date Mar. 22, 1996 PCT Filed Jun. 24, 1994 PCT Pub. No. WO95/01343 PCT Pub. Date Jan. 12, 1995A 3(2H)-pyridazinone derivative of the formula (I) its salt, a process for its production and a pharmaceutical composition containing it.    <IMAGE>  (I)  wherein each of R1, R2 and R3 which are independent of one another, is a hydrogen atom or a C1-4 alkyl group, X is a chlorine atom or a bromine atom, Y1 is a hydrogen atom, a halogen atom, a nitro group, an amino group or a C1-4 alkoxy group, Y2 is a hydrogen atom, a halogen atom, a hydroxyl group, a C1-4 alkyl group or a C1-4 alkoxy group, A is a C1-5 alkylene chain which may be substituted by a hydroxyl group, B is a carbonyl group or a methylene chain which may be substituted by a C1-4 alkyl group, and each of R4 and R5 which are independent of each other, is a C1-4 alkyl group, or R4 is a hydrogen atom and R5 is -Z-Ar (wherein Z is a C1-5 alkylene chain, and Ar is an aromatic 6-membered ring which may contain a nitrogen atom), or R4 and R5 together form a C2-6 cyclic alkylene group, or R4 and R5 form together with the adjacent nitrogen atom a 4-substituted piperazine ring of the formula:   <IMAGE>   wherein R6 is a C1-4 alkyl group.
Patent NO-970164-D0 (NO)
Inventor: HELLENDAHL BEATE
IPC: A61K31/435
Filed: 1997-01-14
Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.