Patent SG-11201810249Y-A (SG)
Title: A pharmaceutical composition and the use thereof in the treatment of autoimmune diseases
Inventor: ALBANI SALVATORE
IPC: A61K38/04
Filed: 2017-05-18
Abstract: SEQID NO:--L--DMARD W O 20 17 / 200 489 Al Figure 7 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 November 2017 (23.11.2017) WIPO I PCT 0111111010 0111 inn III VIII ionoiflo oimIE (10) International Publication Number WO 2017/200489 Al (51) International Patent Classification: A61K 31/4706 (2006.01) A61P 19/02 (2006.01) A61K 38/04 (2006.01) (21) International Application Number: PCT/SG2017/050259 (22) International Filing Date: 18 May 2017 (18.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/338,319 18 May 2016 (18.05.2016) US (71) Applicant: SINGAPORE HEALTH SERVICES PTE. LTD. [SG/SG]; 31 Third Hospital Avenue, #03-03, Singa- pore 168753 (SG). (72) Inventor: ALBANI, Salvatore; 31 Third Hospital Avenue, #03-03, Singapore 168753 (SG). (74) Agent: YUSARN AUDREY; 24 Raffles Place, #27-01 Clifford Centre, SINGAPORE 048621 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) (54) Title: A PHARMACEUTICAL COMPOSITION AND THE USE THEREOF IN THE TREATMENT OF AUTOIMMUNE = DISEASES (57) : The present invention relates to compounds comprising formula I . Amino Acid Sequence-(L)„-DMARD wherein the amino acid sequence comprises QKRAAYDQYGHAAFE-NH2 (SEQ ID NO: 1 ), DMARD is a disease modifying antirheumatic agent, L is a linker unit; - is a covalent bond and n is 0 or 1 and methods of using the compound for treatment of autoimmune diseases. In a preferred embodiment the DMARD is selected from Chloroquine and Hydroxychloroquine. [Continued on next page] WO 2017/200489 Al MIDEDIMOMMIDIRMEM00101011111IMEHOMEMOIMIE Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))