baber/WOPTO huggingface dataset:
Patent HU-230760-B1 (HU)
Title: Optical isomers of dihydro-2,3-benzodiazepine derivatives, process for their stereoselective synthesis, their use, pharmaceutical compositions containing them and the intermediates of the synthesis
Inventor: DR LING ISTVAN
IPC: C07D493/04
Filed: 2005-12-30
Abstract: Enantiomeric dihydro-2,3-benzodiazepine derivatives or their acid addition salts are new. Enantiomeric dihydro-2,3-benzodiazepine derivatives of formula (I) or their acid addition salts are new. X : a halogen or chloro atom, or alkoxy; Y 1halogen or chloro atom; X+Y 1a methylenedioxy group; R : 1-4C alkyl (preferably methyl or ethyl). The configuration of the chiral carbon atom is R or S. Independent claims are included for the following: (1) new intermediate selected from enantiomeric dihydro-2,3-benzodiazepine derivatives of formula (V); enantiomeric benzo[b]pyran derivatives of formula (XII); hydrazone derivatives of formula (XIV); racemic and enantiomeric dihydro-2,3-benzodiazepine derivatives of formula (III); racemic and enantiomeric dihydro-2,3-benzodiazepine compounds of formula (VI); diastereomeric dihydro-2,3-benzodiazepine derivatives having high stereochemical purity of formula (VII); racemic or enantiomeric dihydro-2,3-benzodiazepine compounds of formula (VIII), or their acid addition salts with their optically active acids; (2) a pharmaceutical composition comprising the enantiomeric dihydro-2,3-benzodiazepine derivatives (I) and a carrier; and (3) preparation of the dihydro-2,3-benzodiazepine derivatives (I) (preferably (R)-(-)-7-acetyl-5-(4-amino-3-methylphenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; or (R)-(-)-3-acetyl-1-(4-amino-3-methylphenyl)-8-chloro-4-methyl-4,5-dihydro-3H-2,3-benzodiazepine) of high enantiomeric purity. V 1hydrogen atom or hydroxyl; L 1hydroxyl, or alkyl- or aryl-sulfonyl; R aa substituted arylene, alkylene or alkenylene (preferably cis- or trans-alkenylene, especially cis-ethenylene); R 1T 1 (preferably hydrogen atom); R 2T 1 (preferably methyl); R 3T 1 (preferably phenyl); T 1aliphatic or branched saturated or unsaturated alkyl, aryl or aralkyl (all optionally substituted), or hydrogen atom. The hydrazone compounds (XIV) are mixtures of E and Z isomers. [Image] [Image] [Image] [Image] ACTIVITY : Cerebroprotective; Vasotropic; Neuroprotective; Vulnerary; Anticonvulsant; Neuroleptic; Cytostatic; Muscular-Gen.; Relaxant; Antiparkinsonian; Nootropic; Antiinflammatory; CNS-Gen.; Analgesic; Antiemetic; Antimigraine; Antiaddictive; Tranquilizer. MECHANISM OF ACTION : Non-competitive antagonist of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. The AMPA antagonistic efficacy of (R)-(-)-7-acetyl-5-(4-amino-3-methylphenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine (A1) was evaluated in the chicken retina by using Spreading depression test method as described in Sheardown (1993). The compound (A1) was effective AMPA antagonist compound, because the effect of the AMPA receptor was blocked by 1.8 mu M (EC 50) value.
Patent HU-230576-B1 (HU)
Title: Chimeric infectious dna clones, chimeric porcine circoviruses and uses thereof
Inventor: MENG XIANG-JIN
IPC: A61K39/12
Filed: 2002-12-11
Abstract: The present invention relates to an immunogenic polypeptide product which is obtainable by expressing infectious chimeric DNA clones of porcine circovirus (PCV). The present invention also relates to corresponding vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone is constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position.
Patent JP-2894338-B1 (JP)
Title: 車輌検知器
IPC: G07B15/00
Filed: 1998-02-24
Granted: 1999-05-24
Abstract: 【要約】
【課題】フリーフロー方式に対応したレーンに拘束され ない車輌検知器を提供する。
【解決手段】車輌検知器１は複数車線を有する道路の路 面７の上方に設置され車輌進入を検知する。レンズ２は 複数の車線を撮像する。赤外線センサ３はレンズ２から 受光する赤外線を感知し画像信号８を出力する。画像信 号取込部４は画像信号８を取り込み画像データ９を出力 する。信号処理部５は画像データ９のデータ処理を行な い車輌検知信号１０を出力する。インターフェース部６ は車輌検知信号１０を感知信号１１として外部に出力す る。
Patent JP-2949173-B1 (JP)
Title: 自動販売機用見本展示装置
IPC: G07F9/02
Filed: 1998-03-20
Granted: 1999-09-13
Abstract: 【要約】
【課題】商品表示板の開き方向の弾性が小さい場合であ っても脱落の恐れが少なく、商品の大きさの違いに拘ら ず、共通の保持部材に、商品表示板を好適に装着できる ようにする。
【解決手段】展開方向に反発性を有するシート状で商品 の正面部分の絵柄が表示された商品表示板２０を前方に 突出した略円弧形の横断面形状に湾曲させて着脱自在に 保持する保持部材１０を備え、保持部材１０の表面に設 けた表示板装着部１１に、一対の縦長の係止鍔１４，１ ４が、前方縁側が互いに近づく方向に向けて突設され、 その両係止鍔の内側面に、商品表示板２０の両側縁部表 面側を弾性を持たせて当接させることにより該商品表示 板を着脱自在に保持させる。保持部材に、表裏に貫通し た透光窓１１を設け、その両側縁部を折り曲げて係止鍔 １４を形成させ、商品表示板２０には、その両側縁部に 前記表示板装着窓に挿入される張出部２７を一体に設け る。
Patent JP-3069695-B1 (JP)
Title: マ―カ敷設方法及び装置
IPC: E01F9/524
Filed: 1999-03-29
Granted: 2000-07-24
Abstract: 【要約】
【課題】  マーカの敷設作業及び敷設精度を向上させる と共に、敷設後のマーカの姿勢修正が容易に行うことの できるマーカ敷設方法と装置を提供する。
【解決手段】  マーカの敷設位置を測位手段により測位 し、この位置をマーカの絶対位置とすると共に、敷設後 のマーカに対して前記絶対位置を含む情報を逐次書き込 む、マーカは情報を書き込まない状態で道路に敷設で き、マーカ敷設後に情報環境を考慮した最適な方法によ る絶対情報を書き込むことにより、マーカによる正確な 情報発信を可能とし、走行支援道路と車両との間での路 車間通信をより確実なものとし、完成度の高い「ＡＨＳ システム」を構築する。
Patent JP-2853087-B1 (JP)
Title: 強化セメント組成物
IPC: C04B28/02
Filed: 1998-03-04
Granted: 1999-02-03
Abstract: 【要約】
【目的】利用価値の失ったガラス屑廃材を再利用し、高 強度ポリマーセメント固化体を得る強化セメント組成物 を提供するものである。
【構成】ガラス屑廃材を微細ガラス粉とし、天然ケイ酸 塩鉱物の微細粉粒と共に水硬性セメントの強化骨材とし て用い、水溶性合成樹脂エマルジョンと混合することに より、多量の微細ガラス粉粒を骨材として用いた場合で も極めて強度の高いポリマーセメント固化体を得ること を特長とする強化セメント組成物。
Patent NL-1041824-B1 (NL)
Title: IJsbakje voor consumptie-ijs.
Inventor: ETIENNE HERMAN WALTER BLONDEEL
IPC: A23G9/50
Filed: 2016-04-18
Granted: 2017-11-07
Abstract: IJsbakje (1) van eetbaar materiaal, in het bijzonder krokant wafelmateriaal, ingericht voor het bevatten van een portie consumptie-ijs (2), van welk ijsbakje de hoofdvorm plat en/of langwerpig is en waarbij het ijsbakje zich tijdens normaal transport en consumptie van het ijs in hoofdzaak horizontaal uitstrekt. Het ijsbakje heeft een in hoofdzaak vlakke bodem (3) met zijranden (4) daaromheen en bezit bij voorkeur een langwerpige vorm, waarbij de gemiddelde hoogtemaat (h), over de zijranden gerekend, substantieel kleiner is dan de gemiddelde breedte- of lengtemaat (l)van het ijsbakje. Een of meer, afbreekbare uitsteeksels (6) kunnen zijn aangebracht die zijn ingericht als hulp bij het consumeren van het consumptie-ijs of als versieringselement bij de portie consumptie-ijs.
Patent NL-1042220-B1 (NL)
Title: Multi-mode hydraulic cylinder control system for hydraulic workover unit
Inventor: MICHEAL STEPHEN OSER
IPC: E21B44/00
Filed: 2017-01-13
Granted: 2017-12-13
Abstract: Hydraulic workover system having at least two sets of hydraulic cylinders coupled with a single load. A plurality of control valves transitionable between a closed position and an open position, the plurality of control valves having at least one extend control valve disposed between each set of hydraulic cylinders and an extend supply pump, at least one retract control valve disposed between each set of hydraulic cylinders and a retract supply pump, and at least one float control valve disposed between each set of hydraulic cylinders and a float supply pump. A logic control system coupled with the plurality of control valves and configured to transition the plurality of control valves between the closed and open position, thereby controlling flow between the at least two sets of hydraulic cylinders and the extend supply pump, retract supply pump, and float supply pump.
Patent NL-1042545-B1 (NL)
Title: Well packers
Inventor: SHANE R BURCKHARD
IPC: E21B33/128
Filed: 2017-09-15
Granted: 2018-06-11
Abstract: A packer for wells can include a body having a tubular shape, a sealing element having an upward end and a downward end and disposed around the body. The packer also includes a first prop upward of the sealing element, and a second prop downward of the sealing element. The first prop is configured to wedge under the upward end of the sealing element and the second prop is configured to wedge under the downward end of the sealing element to push the sealing element outward at both the upward end and the downward end.
Patent NL-2014308-B1 (NL)
Title: Submersible vehicle for providing a trench in a subsea bottom.
Inventor: BRUNO TACK
IPC: E02F5/10
Filed: 2015-02-18
Granted: 2016-10-12
Abstract: A remotely operated submersible vehicle for preparing a trench in a subsea bottom is disclosed. The vehicle comprises a frame, hoisting and control cables for suspending the vehicle from a surface vessel, thrusters for manoeuvring the vehicle, and an elongated mechanical excavating tool extending across the width of the trench and connected to conveying means for carrying excavated seabed material to a position outside the trench. The excavating tool comprises an elongated support member that extends across the width of the trench and is provided with a number of cutter devices that are actively driven in a rotation direction around an axis extending substantially perpendicular to the longitudinal direction of the support member in the direction of the trench. A method of preparing a trench using the vehicle is also described.
Patent NL-2015989-B1 (NL)
Title: A method of generating service activities report data from a hand-held processor controlled user device, a computer program product and a hand-held processor controlled user device.
Inventor: MARCO BERENDSEN
IPC: G06Q50/10
Filed: 2015-12-18
Granted: 2017-07-10
Abstract: A method, computer program product and a hand held processor controlled user device for generating service activities report data capturing objects in or at a building to be serviced. Floorplan data representative of a floor of a building or property and at least one object to be serviced at said floor are displayed by a display of the user device. First and second images of an identified object are captured by an image capturing device of the user device, together with first and second timestamp data, marking the start and end of service to be performed in relation to the identified object. From the images and timestamp data captured service activities report data are generated.
Patent NL-2016416-B1 (NL)
Title: Device for storing a bicycle.
Inventor: FEIKO SJOERD WITHAGEN
IPC: B62H3/08
Filed: 2016-03-10
Granted: 2017-09-26
Abstract: A construction for storing bicycles comprises a frame to which a storage platform is swivellably mounted and movable between a lower loading position for loading a bicycle and an upper holding position. The storage platform comprises a bicycle holding unit like a gutter for holding the bicycle. The gutter may be slidably mounted in the storage module. A biasing element like a gas spring is provided for biasing the storage platform to the holding position. The biasing element is provided substantially, but not fully, parallel to the storage platform and may to the largest extend or fully be placed under the storage platform, rather than under a stationary part of the frame. This allows the biasing element to be substantially, but not fully, parallel to the storage platform throughout the trajectory from the lower to the upper position. It allows placement of the biasing element close to the storage platform.
Patent NL-2024218-B1 (NL)
Title: Impact attenuating system
Inventor: TOMAS HUTING
IPC: A63C19/12
Filed: 2019-11-12
Granted: 2021-08-23
Abstract: An impact attenuating system (1; 2) is provided for attenuating impact onto a landing area when exercising freestyle sports such as freestyle cycling, freestyle motorbiking, skiing, snowboarding, skateboarding, inline skating, scootering and alike. The impact attenuating system (1) comprises a first inflatable structure (14). The first inflatable structure (14) comprises a first sheet (101) and a sheet (102). A first side (111) of the first sheet is in contact with and connected to a first side (112) of the second sheet along a first plurality of parallel first connection lines (103-1, 103-2, 103-2) to form a first plurality (104) of parallel first air chambers (104-1, 104-2, 104-3). The first plurality of parallel first air chambers is inflatable to form a first plurality of parallel first tubular airbags arranged side-by-side in a first plane substantially parallel to the top surface of the landing area. A top layer (110) may be provided. A second inflatable structure (24) may be provided on top of the first inflatable structure (14).
Patent NL-2024837-B1 (NL)
Title: Device and method for separating tissue from an intestine
Inventor: THOMAS JOZEF S DE WINTER
IPC: A22C17/16
Filed: 2020-02-05
Granted: 2021-09-13
Abstract: The invention relates to a tissue separating device for separating an intestine from a cluster of organs harvested from an animal, in particular porcine, ovine or bovine, the intestine being connected to the remainder of the cluster through tissue, the tissue separating device comprising: a. a guiding device having at least one guiding surface configured to contact the intestine; b. a tissue severing device configured to provide a separation in the tissue close to the intestine, wherein the guiding device further comprises a first guiding member and a second guiding member being movable with respect to each other to define a gap configured to accommodate said tissue, the gap having a variable gap width, wherein the tissue severing device is configured to be operative in the gap, wherein the tissue separating device further comprises a resilient member configured to exert a force on at least one of the first guiding member and the second guiding member, the force driving the first guiding member and the second guiding member towards each other.
Patent NL-2026261-B1 (NL)
Title: Molecular Marker Closely Linked to Chinese Cabbage Turnip Mosaic Virus Resistance Gene retrcs03 and Application Thereof
Inventor: SHUANTAO LIU
IPC: C12Q1/6895
Filed: 2020-08-12
Granted: 2022-06-03
Abstract: The present invention provides a molecular marker closely linked to the Chinese cabbage turnip mosaic virus resistance gene retrcs03 and application thereof and belongs to the technical field of biology. The molecular marker provided by the present invention further maps the Chinese cabbage TuMV resistance gene retrcs03, which is helpful for better use in Chinese cabbage TuMV-resistant molecular marker-assisted selection. Meanwhile, the gene can be mapped, which lays a foundation for the cloning and in-depth utilization and research of the gene. At the same time, the molecular marker is applied in breeding work, which will greatly reduce the economic loss caused by TuMV prevalence to production of the Chinese cabbage, is conducive to reducing production cost and has great application potential and high economic value.
Patent NL-2031587-B1 (NL)
Title: Toilet seat cover
Inventor: RICARDO POCAI
IPC: A47K13/14
Filed: 2022-04-14
Granted: 2023-10-30
Abstract: The present invention relates to a toilet seat cover (100) built in a single piece, comprising a ﬁrst edge (110) and a second edge (120) which, when surrounding a toilet seat (200), 5 have its perimeters totally or partially overlapped and fastened by the adherence of the material in areas of direct contact with the toilet seat (200) and with each other in overlapping areas (150).
Patent NL-2031910-B1 (NL)
Title: Method and cord organizer for organizing cords between a tire building creel and an extruder
Inventor: JANTINUS SCHRAA
IPC: B29D30/38
Filed: 2022-05-18
Granted: 2023-11-27
Abstract: The invention relates to a method and a cord organizer for organizing cords between a tire building creel and an extruder, wherein the method comprises the steps of: — providing a cord inlay station between the tire 5 building creel and the extruder for preparing the cords for insertion into the extruder; — collecting groups of the cords in a plurality of cord collectors at the tire building creel; and — transferring said plurality of cords collectors 10 with the groups of cords collected therein from the tire building creel towards the cord inlay station.
Patent NL-2032669-B1 (NL)
Title: Intelligent method for diagnosing mechanical fault of high-voltage isolating switch based on transfer learning
Inventor: YUNGUI ZHANG
IPC: H01H33/36
Filed: 2022-08-03
Granted: 2023-05-23
Abstract: The present disclosure relates to the technical ﬁeld of intelligent diagnosis for a high-voltage isolating switch, and in particular, to an intelligent method for diagnosing a 5 mechanical fault of a high-voltage isolating switch based on transfer learning. The method includes: obtaining a large number of power-time signals of a driving motor under various mechanical states of the high-voltage isolating switch by using an electromechanical co-simulation technology, training a multilayer neural network model by using the obtained simulation results as training samples, and further training last 10 several layers of the multilayer neural network by using experimental or ﬁeld measurement data as small samples, to achieve optimal parameters for a single or composite fault diagnosis model. The present disclosure can solve the problem of low accuracy of an intelligent diagnosis algorithm of the high-voltage isolating switch due to insufﬁcient training samples, and can improve the accuracy of the technology for 15 mechanical state diagnosis of the high-voltage isolating switch based on the deep neural network, thus making an intelligent diagnosis result of the high-voltage isolating switch recognized by industry.
Patent RO-106888-B1 (RO)
Inventor: DIACONESCU EUGEN
IPC: C11D3/10
Filed: 1992-12-11
Abstract: Produsele pe bază de sesquicarbonat
de sodiu sunt produse solide, omogene,
neaglomerabile, cu bune proprietăți de curgere
liberă și solubilitate în apă, la temperaturi scăzute,
având în soluție 1%, pH maximum 10,5.
Produsele au în compoziție 2...20% substanțe
superficial-active, în amestecuri binare sau ternare,
cu conținut de sipunuri alcaline, din acizi grași,
naturali, anionici de tip sulfat/sulfonat, neionici
polieto-xilați, 30...80% sesquicarbonat de sodiu
(Na2CO3.NaHCO3.H2O) și alți agenți de
condiționare : tripolifosfat de sodiu, zeoliți
alcalini, perborat de sodiu, agenți specifici de
complexare și antiredepunere etc. în funcție de
compoziție, produsele pot fi folosite pentru
prespălarea, spălarea și fierberea articolelor textile
sau pentru curățarea suprafețelor tari. Produsele
se obțin prin procedee specifice de
amestecare/granulare.
Patent RO-112355-B1 (RO)
Inventor: KIECZYKOWSKI R GERARD
IPC: C07F9/38
Filed: 1992-12-18
Abstract: Invenția se referă la un
procedeu pentru prepararea acidului 4-amino1-hidroxibutiliden-1,1-bifosfonic
(ABP) sau sărurilor
acestuia prin; a) reacția acidului 4-aminobutiric
cu un amestec de acid fosforos și
PCI3 în prezența acidului metansulfonic; b)
aducerea în contact a amestecului de reacție,
rezultat în etapa a), cu un amestec de hidroliză
apoasă, în care pH-ul se menține între 4
și 10, în timpul aducerii în contact; c)
recuperarea acidului 4-amino-1-hidroxibutiliden.
Acest compus se folosește în tratamentul
și prevenirea bolilor de resorbție a
oaselor.
Patent RO-110602-B1 (RO)
Inventor: FLOREA DELIA DANA
IPC: B01D53/86
Filed: 1995-07-07
Abstract: Invenția se referă la un sistem
catalitic, pentru purificarea gazelor de evacuare, de
la motoarele cu ardere internă și la procedeul de
obținere a acestuia. Sistemul catalitic este constituit
dintr-un catalizator zeolitic, care conține cupru și
cobalt, destinat reducerii oxizilor de azot cu
ajutorul hidrocarburilor din gazele de evacuare și
un catalizator zeolitic promotat cu metale platinice,
care realizează oxidarea hidrocarburilor rămase și
a oxidului de carbon la dioxid de carbon și apă.
Procedeul de obținere a sistemului catalitic constă
în depunerea fazelor catalitic active, pe un substrat
monolitic, ceramic sau metalic. Primul catalizator
al sistemului se obține prin depunerea pe substrat a
unui strat catalitic activ, conținând zelitul modificat
cu cobalt sau cupru. Al doilea catalizator al
sistemului se obține prin depunerea peste un strat
conținând zeolit modificat cu cobalt sau cupru a
celui de-al doilea strat conținând alumină, și metale
platinice (platină și paladiu).
Patent RO-112302-B1 (RO)
Title: Ecological construction
Inventor: PANU-MISĂILESCU DUMITRU
IPC: E04H1/02
Filed: 1996-01-18
Abstract: The multipurpose ecological construction is characterized by the recovery /recycling/ upgrading, in a higher degree, of the available primary resources from the environment as : light, solar heat, wind energy and natural ventilation, its direct utilization and by conversion-reconversion, stocking the energy produced by the primary resources without the environment pollution or degradation, and comprises some metal profiles (1), fixed on a bottom metal curved plate (5) wherefrom some metal stops (2) are also radially mounted, said metal stops being caused to splay and sustaining some metal curved beams (3) radially mounted, and having the walls made up of transparent and heat insulating material, and being and provided /equipped with means ensuring the functional independence, without polluting the environment.
Patent RO-115224-B1 (RO)
Inventor: GODEANU MARIOARA
IPC: A23L5/40
Filed: 1997-01-27
Abstract: Invenția se referă la un
concentrat antocianic și la procedeul de
obținere. Concentratul antocianic se prezintă
atât sub formă de lichid vâscos, opac, de
culoare roșie-violacee, cu gust astringent și
aromă de afine, cu 16... 20 % substanță
uscată solubilă, 50... 55 g/l conținut de
antocianozide, 3,2... 3,5 % acid citric și/sau
malic, tartric, 1,85...1,95 % săruri minerale,
17... 20 % reziduu la evaporare, 0,10 %
sorbat de NA/K, putere de colorare 15... 20
u.Co, pH = 2... 2,5, și urme de alcool etilic,
cât și sub formă de pulbere amorfă având
minimum 95 % substanță uscată și un
conținut de antocianozide de 17... 22 %.
Procedeul de obținere a concentratului presupune
două etape de realizare, în prima
etapă, efectuându-se extracția principiilor active
din turta de afine, prin percolarea turtei de
afine cu o soluție hidroalcoolică acidulată,
având 70 % volum alcool etilic și 3 % acid
citric, malic sau tartric, raportul de flotă
optim, între cantitatea de solvent și de produs
vegetal, fiind de 3:1... 7:1, durata extracției
de 24... 48 h la temperatura ambiantă, sau
de 2... 3 h, la temperatura 70... 75°C, cu
recircularea forțată a solventului, prin
pompare sau refluxare, urmată de filtrare prin
pânză deasă și un strat de vată de 5... 10
cm grosime, adăugare de 0,1 % sorbat de
Na/K, iar în a doua etapă, concentrarea extractului
prin dezalcoolizare la vid, prin încălzire
cu abur, în aparate cu manta dublă,
prevăzute cu dispozitiv de agitare, până când
concentrația alcoolului recuperat scade sub
94 % volum și colectarea concentratului
antocianic, urmată, pentru produsul pulverulent,
de uscare sau liofilizare. Concentratul
antocianic, obținut conform procedeului prezentei
invenții, poate fi folosit drept colorant
alimentar și în produse farmaceutice, cu efect
terapeutic în afecțiunile oftalmologice, capilare,
hemoragice.
Patent RO-119196-B1 (RO)
Title: 1,2-ethanediol derivatives and the utilization thereof as potentiator for nerve growth factor activity
Inventor: ONO SATOSHI
IPC: C07D333/54
Filed: 1995-10-20
Abstract: The invention relates to 1,2-ethanediol derivative represented by the general formula (I) or to the salts thereof, which potentiate the nerve growth factor activity, and to the utilization of some 1,2-ethanediol derivatives represented by the general formula I or of the salts thereof, which potentiate the nerve growth factor activity, for the preparation of a medicament for diseases caused by the central or peripheral nervous system degenaration.