baber/WOPTO huggingface dataset:
Patent RU-2498976-C9 (RU)
Title: Усовершенствованный способ получения ингибитора дипептидилпептидазы-iv и промежуточного соединения
Inventor: KWAK WOO YOUNG
IPC: C07C213/00
Filed: 2010-03-30
Granted: 2014-02-27
Abstract: Настоящее изобретение относится к усовершенствованному способу производства ингибитора дипептидилпептидазы-IV, представленного химической формулой 1. Способ показан на схеме реакции 
     
       
     
     Способ включает следующие стадии: (стадия 1) получение соединения, представленного химической формулой 4, путем связывания пептидной связью соединения, представленного химической формулой 2, и соединения, представленного химической формулой 3, путем осуществления их взаимодействия с использованием изобутилхлорформиата и основания в присутствии реакционного растворителя; и (стадия 2) получение соединения, представленного химической формулой 1, удалением защитной группы амина с соединения, представленного химической формулой 4, полученного на вышеприведенной стадии (1). На схеме реакции PG представляет собой защитную группу; X представляет собой OR 1 , где R 1  представляет собой низший C 1 -C 5 алкил; HY представляет собой свободную кислоту. Предлагаемый способ позволяет повысить выход ингибитора дипептидилпептидазы-IV, представленного химической формулой 1. Изобретение относится также к способу производства соединения, представленного химической формулой 2, и к промежуточному соединению, используемому при получении соединения, представленного химической формулой 3. 3 н. и 9 з.п. ф-лы, 8 пр.
Patent RU-2576738-C9 (RU)
Inventor: KRJUCHKOV VIKTOR ALEKSEEVICH
IPC: F25J3/08
Filed: 2014-11-14
Granted: 2016-05-20
Abstract: FIELD: oil and gas industry. 
     SUBSTANCE: method includes primary separation of raw natural gas flow with separation of water and gas condensate from it and further treatment of the separated gas from acid components containing hydrogen sulphide and carbon dioxide. Treatment from acid components is performed at two stages: at first hydrogen sulphide removal stage is implemented using adsorbent with hydrogen fractional selectivity and at the next stage carbon dioxide is removed using ultrasound separation. At that gas condensate upon primary separation and ultrasound separation is subjected to stabilization process and in this process gas is returned to hydrogen sulphide removal stage. Hydrogen sulphide upon hydrogen sulphide removal stage is sent to sulphur recovery stage by means of Claus conversion process, the obtained sulphur is subjected to degassing and gas from sulphur degassing is returned to sulphur recovery stage. 
     EFFECT: improved treatment degree for natural gas from hydrogen sulphide and carbon dioxide at fuller conversion of sulphur compounds. 
     14 cl, 1 tbl, 1 dwg
Patent DK-21687-D0 (DK)
Inventor: LIPINSKI CHRISTOPHER ANDREW
IPC: C07D311/96
Filed: 1987-01-16
Abstract: Racemic and chiral (2R,4R)-4-c-hydroxy-2-r-(substituted) chroman (and thiochroman)-4-acetic acids and their pharmaceutically acceptable salts useful in the treatment of diabetic complications, and intermediates therefor.
Patent DK-33991-D0 (DK)
Inventor: LYNCH GARY S
IPC: C07K1/22
Filed: 1991-02-27
Abstract: The invention provides a method for the detection of cellular pathology by means of an immunoassay to determine the presence of stable breakdown products, termed BDP's or BDP1 and BDP2, of the cytoskeleton component spectrin. In one aspect of the invention, the components from a sample of spectrin-containing cells are physically separated, as by exposure to an electric field, in such a way that BDP and spectrin are separated. Antibodies reactive with BDP are then contacted with the separated sample, and their binding to that portion of the sample containing any BDP determined.
Patent DK-74783-D0 (DK)
Inventor: CONNOR DAVID THOMAS
IPC: C07D491/14
Filed: 1983-02-21
Abstract: Antichofinergic 3-[2-(mono- and dialkylamino)-propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano [3,4-c]-pyridin-5-ones, useful for treating bronchospastic diseases in mammals, are disclosed. Also disclosed are processes for preparing the compounds, and pharmaceutical compositions containing them. The novel compounds have the following formula:where X is a lower alkyl radial, Y is hydrogen or a lower alkyl, and R', R<sup>2</sup> and R<sup>3</sup> are, separately, hydrogen atoms or substituents.A process for preparing the intermediate which is required to prepare the unsubstituted benzopyrano-[3,4-c]pyridin-5- ones of the present invention is also disclosed
Patent DK-181386-D0 (DK)
Inventor: BLABER MICHAEL
IPC: C12N15/58
Filed: 1986-04-21
Abstract: Compsn. comprises a protease resistant single-chain urokinase (I). (I) may be prepd. by (a) providing nucleic acid encoding a protease-resistant amino acid sequence variant of single-chain urokinase, (b) transforming a host cell with the nucleic acid, (c) culturing the transformed host cell until the variant urokinase accumulates in the culture and (d) recovering the variant urokinase from the culture. (I) is produced by combining urokinase with an agent to complex with urokinase or by covalently modifying single-chain urokinase at sites of proteolysis. The target sites include Arg156 to Lys158 and, pref., the site at residues Lys135 to Lys136. Covalent modifications are accomplished by reacting native urokinase with derivatising reagents or by the recombinant synthesis of mutants having site specific substns., insertions or deletions of amino acid residues at target sites. Complexing agents such as antibodies bind to urokinase at the target sites or at flanking sites so that access to the sites by proteases is impeded or prevented.
Patent DK-248184-D0 (DK)
Inventor: NYFELER ROBERT
IPC: C07D249/08
Filed: 1984-05-17
Abstract: Essentially, a process is described for the preparation of the 1-triazolylethyl ether derivatives, defined in claim 1, of the general formula I   <IMAGE> (I)  which consists in (a) reacting an oxirane of the formula II   <IMAGE> (II)   at temperatures of -20 DEG to +100 DEG  C., in the presence of an acid catalyst or an acid condensation agent, with an alcohol of the formula III R3-OH (III) to give a glycol monoether of the formula IV   <IMAGE> (IV)   and (b) subsequently reacting the glycol monoether of the formula IV or one of its esters, in the presence of an acid-binding agent or condensation agent, at temperatures of 0 DEG  to 150 DEG  C., with a triazole of the formula V   <IMAGE> (V)   the substituents R1, R2 ; amd R3 in the formula II to IV being as defined under formula I and M in formula V being hydrogen or a metal atom. The novel compounds within the scope of formula I and their use are also described.
Patent DK-434787-D0 (DK)
Inventor: LELING MENNO
IPC: E01C5/00
Filed: 1987-08-20
Abstract: 1. Soil covering made of (concrete) shaped blocks which are laid at a distance from one another for the formation of vegetation growth, spacers being arranged in the longitudinal joints and transverse joints thus formed, characterized in that the spacers (17, 17a; 18; 19, 19a) consist of material which dissolves or decomposes in soil, in particular of wood, wooden material (chip material), waste paper, plastic or the like.
Patent DK-455187-D0 (DK)
Inventor: RASMUSSEN GEORG
IPC: B27M/
Filed: 1987-08-31
Abstract: A furniture frame part or the like is made from a first, planar laminate of wood or other material. This laminate is bent so as to form a shaped member of single curvature. The shaped member is cut into slices in a direction transverse to the generatrices of the curvature, and from these slices a second laminate is made. This second laminate is bent in a direction so as to form another curvature with generatrices extending generally transversely to the first mentioned generatrices, whereby a furniture frame part or another composite body of double curvature may be made.
Patent DK-534089-D0 (DK)
Inventor: BRANDMAN HAROLD A
IPC: A01N39/00
Filed: 1989-10-26
Abstract: Useful as antimicrobial agents are  beta -substituted  alpha -halo-acrylonitriles of formula (I), wherein X represents chlorine, bromine or iodine and R represents a lower alkyl, aryl, aralkyl, heterocyclyl, or thiocarbonyl group. These compounds may be incorporated in aqueous compositions subject to spoilage by microbial growth to control such growth. All the compounds apart from  alpha -bromo- beta -methylthio-acrylonitrile and the corresponding  beta -phenylthio compound are novel and may be produced (in a final reaction step) by nucleophilic-type displacement of the  beta -halogen atom X of an appropriate  alpha , beta -dihalo-acrylonitrile X-CH=CX(CN) (IV) using a sulfur anion RS< THETA > derived from the appropriate mercaptan RSH.
Patent DK-624387-D0 (DK)
Inventor: BIEDERSTEDT LUTZ
IPC: G02B6/44
Filed: 1987-11-27
Abstract: A splice cassette housing for optical waveguides has to be brought from an installation position, e.g. a socket-type housing, to a splice position. The incoming and outgoing optical waveguide cables fed with known splice cassette housings along the longitudinal sidewalls are disadvantageous for the free mobility of the splice cassette housing. In order to achieve a high degree of freedom in the mobility of the splice cassette housing, the incoming and outgoing optical waveguide cables 8 and 9 are usually fed separately from each other to the splice cassette housing in a common axis within a flexible hose. Further, a groove-type guide channel 11 in the shape of a member "9" is provided in the bottom 6 of the housing for a change in direction of one of the optical waveguide cables by 180 DEG , in order to be able to feed the individual optical waveguides again from opposed directions to the splice position. The splice cassette housing is suitable for applications especially in cable-terminal boxes, but also in cable distributors and the like for glass-fiber cables.
Patent DK-631188-D0 (DK)
Inventor: LANG HANS-JOCHEN
IPC: C07D/
Filed: 1988-11-11
Abstract: Substituted thienoimidzaole derivatives, processes for their preparation, pharmaceutical preparations containing them and their use as inhibitors of gastric acid secretion. The invention relates to substituted thienoimidazole derivatives of the formula   <IMAGE> (I) in which A stands for  <IMAGE>  T denotes -S-, -SO- or -SO2-, R7 denotes a substituted aryloxy or aralkoxy radical and R1, R2, R3, R4, R5, R6 and R8 have the meanings indicated in the description, processes for their preparation, pharmaceutical preparations containing them and their use as medicaments.
Patent HU-902603-D0 (HU)
Title: Process for the preparation of beta, gamma-unsaturated acids
Inventor: DENIS PHILIPPE
IPC: C07C57/03
Filed: 1990-04-27
Abstract: Process for the preparation of  beta , gamma -unsaturated acids by carbonylation of allyl alcohols. 
<??>The process comprises bringing into contact an allyl alcohol, carbon monoxide and a palladium-based catalyst at elevated temperature and at a pressure above atmospheric pressure. It is characterised in that the operation is also carried out in the presence of at least one quaternary onium chloride of a group VB element chosen from nitrogen and phosphorus, the said element being tetracoordinated to carbon atoms, it being possible for the nitrogen to be coordinated to two pentavalent phosphorus atoms. 
<??>The process is particularly suited for the preparation of 3-hexene-1,6-dioic acid from butenediols.
Patent HU-903879-D0 (HU)
Title: Pesticide preparatives containing n-phenyl-pyrazole derivatives and process for producing the active substance
Inventor: ROBERTS DAVID ALAN
IPC: C07D231/28
Filed: 1990-06-15
Abstract: The invention provides N-phenylpyrazole derivatives of the formula:   <CHEM> wherein R<1> represents alkyl optionally substituted by halogen, R<2> represents alkyl, alkenyl or alkynyl optionally substituted by halogen, R<3> represents a phenyl group substituted in the 2-position by halogen; in the 4-position by optionally halo substituted alkyl or alkoxy; and optionally in the 6-position by halogen; and m and n are independently 0, 1 or 2; which are active against arthropod, plant nematode, helminth and protozoal pests.
Patent NO-862601-D0 (NO)
Inventor: MURRAY MARK J
IPC: C12P21/00
Filed: 1986-06-27
Abstract: Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C and recombinant transfer vectors comprising these sequences are disclosed. Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C. The protein, which may be in the form of activated protein C, is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid includes a promoter followed downstream by a nucleotide sequence which enoodes a protein having substantially the same structure and/or activity as human protein C, the nucleotide sequence being followed downstream by a polyadenylation signal.
Patent NO-863641-D0 (NO)
Inventor: FERGUSON LUCIAN G
IPC: G06K7/10
Filed: 1986-09-12
Abstract: A batteryless, portable, transponder useful in a tag for a presence detection system. The transponder detects electromagnetic radiation at a first predetermined frequency and responds to said detection by transmitting electromagnetic radiation at a second frequency that is a subharmonic of the first frequency. The transponder includes an amorphous magnetic material component (48) for storing energy from the electromagnetic radiation detected at the first frequency for transmission as the electromagnetic radiation transmitted at the second frequency. In one embodiment (Figure 9A), the transponder includes a thin, flat ribbon (48) of low coercivity magnetostrictive amorphous magnetic material having a transverse uniaxial magnetic anisotropy defining a magneto- mechanical resonant frequency "f" in accordance with the dimensions of the ribbon, when in the presence of a magnetic bias field of a predetermined intensity, wherein the ribbon responds to the detection of electromagnetic radiation having a frequency "2f" by transmitting electromagnetic radiation at a subharmonic of the frequency "2f"; and means for biasing the ribbon with the predetermined magnetic bias field. In another embodiment (Figure 1), the transponder consists of a single resonant circuit including a nonlinear inductor (L1) having a core made of amorphous magnetic material; and a capacitance (C1) connected in series with the inductor to define the resonant circuit. The core of the nonlinear inductor includes an elongated thin, flat ribbon of low coercivity amorphous magnetic material. It has been observed that this resonant circuit exhibits a bifurcated frequency-division characteristic in relation to the amplitude of the detected electromagnetic radiation at the first predetermined frequency, whereby additional frequency divisions occur as the amplitude is increased. A coded tag (Figure 10) includes two amorphous magnetic material transponders (60, 62) that detect electromagnetic radiation at different frequencies.
Patent NO-864567-D0 (NO)
Inventor: MARTINEZ ROBERT
IPC: B65D75/36
Filed: 1986-11-17
Abstract: A molded blister package for storing and dispensing a hydrophilic contact lens comprises a base portion which includes a cavity surrounded by a outstanding flange, and a cover sheet sealed to the flange to enclose the cavity. A portion of the side wall of the cavity is inclined to form a ramp to the flange. The cover sheet may be stripped from the flange to expose the cavity and inclined side wall whereupon the lens is readily removed by sliding up and out of the cavity along the inclined surface.
Patent NO-905150-D0 (NO)
Inventor: COUNTS MARY E
IPC: A24F40/90
Filed: 1990-11-28
Abstract: Methods and apparatus for releasing flavor components from a flavor-generating medium using an electric heating element are provided. A non-combustion flavor-generating article (10) uses electrical energy to power a heating element (14) which heats tobacco or other flavorants (12) in a flavor generating medium. The flavor-generating medium is formed into a packed bed. Energy delivered to the heating element is regulated to maintain the flavor- generating medium at a relatively constant operating temperature to ensure a relatively constant release of flavor and to ensure that release of flavor components is due to heating, rather than burning of the flavor generating medium. <IMAGE>
Patent NO-912125-D0 (NO)
Inventor: BEHLER ANSGAR
IPC: C09K23/10
Filed: 1991-06-03
Abstract: Description of a process for the flotation of fillers in the presence of tensides containing sulphonate groups.
Patent NO-912252-D0 (NO)
Inventor: SUGIMOTO HACHIRO
IPC: C07D498/04
Filed: 1991-06-12
Abstract: The cyclic amide derivative is defined by the formula (I) or a  salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is <CHEM> R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.
Patent NO-924523-D0 (NO)
Inventor: BAKER STEPHEN RICHARD
IPC: C07C235/34
Filed: 1992-11-24
Abstract: Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists.
Patent NO-924924-D0 (NO)
Inventor: EXNER REINER
IPC: C08G63/692
Filed: 1992-12-18
Abstract: An aqueous filler composition containing a polyester resin which is built up from the starting materials (a), (b), (c), (d) and (e) or ester-forming derivatives thereof, where the sum of the reactants corresponds to 100 mol% and the ratio between the sum of the hydroxyl equivalents (eq of OH) and the sum of the carboxyl equivalents in the reactants is between 0.5 and 2.0, where   (a) is at least one dicarboxylic acid which is not a sulpho or phosphorus monomer, (b) from 0 to 15 mol% of at least one difunctional sulpho or phosphono monomer whose functional groups are carboxyl or hydroxyl groups, containing at least one sulphonate or phosphonate group, (c) at least one difunctional compound which is derived from a glycol containing two -C(R)2-OH groups, (d) up to 40 mol% of a higher-functional compound (functionality > 2) whose functional groups comprise hydroxyl and/or carboxyl groups, and   (e) from 0 to 20 mol% of a monofunctional carboxylic acid, where the radicals R in (c) may be, independently of one another, hydrogen, C1-C4-alkyl or C6-C10-aryl, the amounts of free hydroxyl groups are between 30 and 350 milliequivalents of OH/100 g, preferably between 100 and 250 meq of OH/100 g, and the content of free neutralised and/or neutralisable acid groups, in particular sulphonic, phosphonic or carboxyl groups, is between 5 and 350 meq of acid groups/100 g, preferably between 9 and 120 meq of acid groups/100 g.
Patent NO-933362-D0 (NO)
Inventor: IVANOV KOLIO
IPC: H04W36/04
Filed: 1993-09-21
Abstract: In the speed-dependent handover method for hierarchical cell structures described here, it is ascertained whether the mobile stations have passed through the radio coverage area of a microcell within a time interval. If the mobile stations are still in the radio coverage area with respect to the microcell after the time interval, a handover is requested for the relevant mobile stations into the microcell. <IMAGE>
Patent NO-943166-D0 (NO)
Inventor: HIGUCHI RUSSEL G
IPC: C12Q1/68
Filed: 1994-08-26
Abstract: An apparatus for monitoring multiple nucleic acid amplifications simultaneously. In order to provide real-time monitoring of the amplification product of multiple nucleic acid amplifications simultaneously the apparatus is characterized in that it comprises a thermal cycler (12) including a heat conducting member having multiple recesses formed therein; and a sensor (16a) arranged for detecting light emitted from said recesses, simultaneously. <IMAGE>
Patent NO-944422-D0 (NO)
Inventor: HOLM NIELS-ERIK
IPC: B04B1/00
Filed: 1994-11-18
Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed. The apparatus further includes a liquid supply means for supplying the liquid sample to the annular chamber, a motor means for rotating the phase separation container round its longitudinal axis at a rotational speed causing a separation of the liquid sample into the phase portions, and an actuator means for displacing the piston body within the annular chamber.
Patent NO-950093-D0 (NO)
Inventor: MENCKE NORBERT
IPC: A61K38/08
Filed: 1995-01-10
Abstract: Endoparasitic activity of cyclic depsipeptides (I) comprising amino acid and hydroxycarboxylic acid units and having 6-30 ring atoms is increased by praziquantel (II) and epsiprantel (III). An endoparasitic agent contg. (I) together with (II) and (III) is also claimed. Known cpds. (I) are disclosed in EP382173 (depsipeptide PF 1022), WO9319053, J. Antibiotics 45 (1992) pp. 1207-1255 and pp 1273-1277, Helv. Chimn. Acta 46 (1963) pp 927-935 and pp 1715-1720, ibid, 47 (1964) pp. 166-173, Tetrahedron Letters 2 (1971) pp. 159-162, Biochem. Biophys. Res. Commun. 57 (1974) pp. 554-561 and Zh. Obshch. Khim. 41-(10) (10972) pp. 2320-2334. (II) is known from GB1441554 and (II) is known from EP134984 and EP185012.
Patent NO-951152-D0 (NO)
Inventor: JENNINGS HAROLD J
IPC: A61K47/48
Filed: 1995-03-24
Abstract: Antigenic conjugate (A) comprising (1) a capsular polysaccharide (CPS) of type II or V G.B Streptococcus and (2) a protein (I) linked to 2 or more side chains, terminating in sialic acid residues, of CPS through a sec. amino bond is new. CPS has mol.wt. at least 5000. Pref. 5-50% of terminal sialic acid residues are available for linkage to (I); esp. about 7% or 25% for type II or type V CPS respectively. Partic. (I) are tetanus or diphtheria toxoid, or cross reactive material 197.
Patent NO-952376-D0 (NO)
Inventor: WIESNER HAGEN-HEINZ
IPC: B62D55/20
Filed: 1995-06-15
Abstract: The track chain has rubber mounted drive bodies (10) made of metal located on the wall connecting pins (13). The drive wheel (1) is formed as a polygon, and the flat bearing faces of the polygon are provided with rubber tyres (2,3). The drive body consists of a metal sleeve (22) which is mounted on a bearing bush (20) via a radially prestressed rubber cover (21). The annular chamber between the bearing bush and drive sleeve has edge-side free spaces (23) for the rubber cover. <IMAGE>