Patent SG-194976-A1 (SG)
Title: Novel compounds as diacylglycerol acyltransferase inhibitors
Inventor: QIN DONGHUI
Filed: 2012-05-18
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(43) International Publication Date 29 November 2012 (29.11.2012) WIPO I PCT (10) International Publication NumberWO 2012/162127 Al (51) International Patent Classification: A61K 31/17 (2006.01)International Application Number: PCT/1JS2012/038520International Filing Date: 18 May 2012 (18.05.2012)Filing Language: EnglishPublication Language: English(30) Priority Data:1451/DEL/2011 20 May 2011 (20.05.2011) IN61/495,049 9 June 2011 (09.06.2011) US(71) Applicant (for all designated States except US): GLAX0- SMITHKLINE LLC [US/US]; One Franklin Plaza, 200 North 16th Street, Philadelphia, PA 19102 (US).Applicant (for US only): CHRISTENSEN, Rowena (heir ess of the deceased inventor) [US/US]; 520 State Street, New Orleans, LA 70118 (US).Inventor: CHRISTENSEN, Siegfried, Benjamin, IV (de ceased).(72) Inventors; and(75) Inventors/Applicants (for US only): QIN, Donghui [US/US]; 1250 South Collegeville Road, Collegeville, PA 19426 (US). JOSHI, Hemant [IN/IN]; Navi-Mumbai (IN). TANGIRALA, Reghuram [IN/IN]; Navi-Mumbai (IN).(74) Agents: PENG, Tony, W. et al.; GlaxoSmithKline, Cor porate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US).(81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.(84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, ML, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).Published:with international search report (Art. 21(3))before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS(57) Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT- 1 dysfunction or where modulation of DGAT- 1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.