Patent CA-3096507-A1 (CA)
Title: Pd-l1 binding affimers and uses related thereto
Inventor: BASRAN AMRIK
IPC: C07K14/81
Filed: 2019-04-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property             111111 10111E01111110111 11111 Organization International Bureau                             (10) International Publication Number (43) International Publication Date                WO 2019/197583 Al 17 October 2019 (17.10.2019)    WIPO I PCT (51) International Patent Classification: C07K 14/705 (2006.01)    C07K 14/81 (2006.01)    Published: A61K 38/17 (2006.0        ¨ with international search report (Art. 21(3)) 1) ¨                                            before the expiration of the time limit for amending the (21) International Application Number:    claims and to be republished in the event of receipt of PCT/EP2019/059354    amendments (Rule 48.2(h)) (22) International Filing Date:    ¨ with sequence listing part of description (Rule 5.2(a)) 11 April 2019 (11.04.2019) (25) Filing Language:                   English (26) Publication Language:              English (30) Priority Data: 1805963.4         11 April 2018 (11.04.2018)    GB (71) Applicant: AVACTA LIFE SCIENCES LIMITED  [GB/GB]; Unit 20 Ash Way, Thoip Arch Estate, Wetherby LS23 7FA (GB). (72) Inventors: BASRAN, Amrik; 42 Beaumont Road, Cam-bridge CB1 8PY (GB). JENKINS, Emma; 47 Brook Road, Stansted CM24 8BB (GB). ADAM, Estelle; 2 Capswell Court, Hitchin SG5 lET (GB). WRITER, Michelle; 32 Charles Street, Cambridge CB 1 3LZ (GB). STANLEY, Emma; 65 West Hill, Hitchin SG5 21-IY (GB). (74) Agent: HOFFMANN EITLE PATENT- UND  RECHTSANWÄLTE PARTMBB, ASSOCIATION  NO. 151; Arabellastra e 30, 81925 Munich (DE). ______________________________________  (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL. IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. ______________________________________  (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SL SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). OC Uri 01  __________________________________________________________________________ (54) Title: PD-Ll BINDING AFFIMERS, AND USES RELATED THERETO (57) Abstract: The present disclosure relates to proteins including PD-L 1 binding affimer polypeptide sequences, gene expression 0 constructs encoded those proteins, cells expressing those proteins, and pharmaceutical preparations of those proteins, gene expression " constructs and cells and use in the treatment of various human conditions including cancer.