Patent SG-11201900633X-A (SG)
Title: Piperidine cxcr7 receptor modulators
Inventor: AISSAOUI HAMED
IPC: C07D413/14
Filed: 2017-07-27
Abstract: International Patent Classification: CO7D 413/14 (2006.01) A61P 29/00 A61K 31/4545 (2006.01) A61P 35/00 A61K 31/506 (2006.01) A61P 43/00 (2006.01) (2006.01) (2006.01) (21) International Application Number: N R 2 (I) O C 1-1 (54) Title: PIPERIDINE CXCR7 RECEPTOR MODULATORS O HN :(R*) Are 1-1 ' 15 R R3 • ,• (R*) . RArl (57) : The present invention relates to piperidine derivatives of formula (I) wherein Ar l , Art, R r1 ,R 1 , R2, and R 3 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions con- taining one or more compounds of formula (I), and especially to their use as CXCR7 receptor mod- ulators. (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIP0 I PCT Iiiimmoliononotioloolumionolomioniovoiml (10) International Publication Number WO 2018/019929 Al PCT/EP2017/068990 (22) International Filing Date: 27 July 2017 (27.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2016/068052 28 July 2016 (28.07.2016) EP (71) Applicant: IDORSIA PHARMACEUTICALS LTD [CH/CH]; Hegenheimermattweg 91, 4123 Allschwil (CH). (72) Inventors: AISSAOUI, Hamed; c/o Idorsia Pharmaceuti- cals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). GUERRY, Philippe; c/o Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). LEHEM- BRE, Francois; c/o Idorsia Pharmaceuticals Ltd, Hegen- heimermattweg 91, 4123 Allschwil (CH). POTHIER, Julien; c/o Idorsia Pharmaceuticals Ltd, Hegenheimermat- tweg 91, 4123 Allschwil (CH). POUZOL, Laetitia; c/ o Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). RICHARD-BILDSTEIN, Sylvia; c/ o Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). YUAN, Shuguang; c/o Idorsia Phar- maceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). (74) Agent: VELKER, Jorg; c/o Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))