Patent SG-11201908235R-A (SG)
Title: An isoxazole derivatives as nuclear receptor agonists and used thereof
Inventor: KANG JAE-HOON
IPC: C07D261/08
Filed: 2018-04-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PCT omit VIII °nolo Oil mo 1101 loom!! ono oimIE (10) International Publication Number WO 2018/190643 Al (51) International Patent Classification: C07D 261/08 (2006.01) A61K 31/42 (2006.01) (21) International Application Number: PCT/KR2018/004277 (22) International Filing Date: 12 April 2018 (12.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10-2017-0047393 12 April 2017 (12.04.2017) KR 10-2018-0042545 12 April 2018 (12.04.2018) KR (71) Applicant: IL DONG PHARMACEUTICAL CO., LTD. [KR/KR]; 2, Baumoe-ro 27-gil, Seocho-gu, Seoul 06752 (KR). (72) Inventors: KANG, Jae-Hoon; 407, 23, Gangnam-daero 61-gil, Seocho-gu, Seoul 06616 (KR). LEE, Hong- Sub; 108-1402, 21-11, Gugal-ro 28beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 16973 (KR). LEE, Yoon-Suk; 618-1602, 41, Dongtanbanseok-ro, Hwaseong-si, Gyeong- gi-do 18442 (KR). JEONG, Jin-Ah; 2nd floor, 38-3, Han- cheon-ro 69-gil, Seongbuk-gu, Seoul 02785 (KR). KWON, Sung-Wook; 301, 59-8, Yeoul-ro 4-gil, Hwaseong-si, Gyeonggi-do 18422 (KR). KIM, Jeong-Guen; 2236-403, 115, Dongtansunhwan-daero 20-gil, Hwaseong-si, Gyeong- gi-do 18484 (KR). KIM, Kyung-Sun; 215-304, 299, Sanbon-ro, Gunpo-si, Gyeonggi-do 15862 (KR). SONG, Dong-Keun; 8-413, 8, Songpa-daero 32-gil, Songpa-gu, Seoul 05711 (KR). PARK, Sun-Young; 412, 23-4, Keun- jaebong-gil, Hwaseong-si, Gyeonggi-do 18450 (KR). KIM, Kyeo-Jin; 105-305, 120, Irwon-ro, Gangnam-gu, Seoul 06356 (KR). CHOI, Ji-Hye; 812, 23-11, Keunj aebong-gil, Hwaseong-si, Gyeonggi-do 18450 (KR). HWANG, Hey- Min; East-802, 17, Dasan-ro 46-gil, Jung-gu, Seoul 04570 (KR). (74) Agent: LEE, Myoung-Jin; 6th floor, 28, Yeongdong-daero 85-gil, Gangnam-gu, Seoul 06180 (KR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: - with international search report (Art. 21(3)) 00 (54) Title: AN ISOXAZOLE DERIVATIVES AS NUCLEAR RECEPTOR AGONISTS AND USED THEREOF C0 (57) : The present invention relates to isoxazole derivatives, including pharmaceutical compositions and for the preparation \" of isoxazole derivatives. And more particularly the present invention provided a pharmaceutical composition of isoxazole derivatives 0 for activation of Farnesoid X receptor(FXR, NR1H4).