Patent SG-11201806822V-A (SG)
Title: Early detection of hepatocellular carcinoma
Inventor: BLOCK TIMOTHY
IPC: G01N33/68
Filed: 2017-02-16
Abstract: FIGI W O 20 1714697 / 1 Al (57) : Provided are methods, assays, and kits for detecting hepatocellular carcinoma, as well as methods for stratifying subjects among higher and lower risk categories for having hepatocellular carcinoma, and methods of treating and managing treatment of subjects that are suspected or at risk of having hepatocellular carcinoma. Although pre- vious work has attempted to address the need for a highly sensitive, early predictor of hepatocellular carcinoma by assessment of one or more biologic- al factors, none have approached the degree of sensitivity that is required for clinically relevant determination of whether a subject, especially a non-symptomatic subject, has that condition. The present inventors have discovered that certain combinations of factors fulfill this need by confer- ring a high level of accuracy that was not previ- ously attainable. A AUROC (95% CI) 0.98 0.98 0.97 0.96 125% 103% 0.8 48% .1 0.7 0.5 1,1\" q, S qfle Co C. G A t, + c, A o A ct A ct e e e All Early-stage AFP- Early-stage AND AFP- 120 100 80 60 as 20 20 All: HCC (N=I15) vs. cirrhosis (N=93) Early-stage: HCC UNOS stage T I/T2 (N=69) vs. cirrhosis (N=93) AFP - (< 20 ng/mL): HCC (N9) vs. cirrhosis (N=84) Early-stage AND AFP HCC (N-29) vs. cirrhosis (N-84.) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/146971 Al 31 August 2017 (31.08.2017) WIPO I PCT 111111111111110111011111111111010111110111010111111111111101111101111111110111111 (51) International Patent Classification: A61K 38/16 (2006.01) GO1N 33/53 (2006.01) C07K 16/06 (2006.01) GO1N 33/574 (2006.01) GO1N 33/68 (2006.01) (21) International Application Number: PCT/US2017/018040 (22) International Filing Date: 16 February 2017 (16.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/300,142 26 February 2016 (26.02.2016) US (71) Applicant: DREXEL UNIVERSITY [US/US]; 3141 Chestnut Street, Philadelphia, PA 19104 (US). (72) Inventors: BLOCK, Timothy, M.; 90 Foxcroft Drive, Doylestown, PA 18901 (US). WANG, Mengjun; 142 Filly Dr., North Wales, PA 19454 (US). MEHTA, Anand; 107 Brook Circle, Lansdale, PA 19446 (US). (74) Agent: HOFFMAN, David, B.; Baker & Hostetler LLP, 2929 Arch Street, Cira Centre, 12th Floor, Philadelphia, PA 19104-2891 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: EARLY DETECTION OF HEPATOCELLULAR CARCINOMA