Patent SG-11201901066U-A (SG)
Title: Novel alkaline stable immunoglobulin-binding proteins
Inventor: KNICK PAUL
IPC: C07K14/31
Filed: 2017-08-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 01E101011M vu H 1 0 011101 OHM 3100111111110111011 lil Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/029157 Al 15 February 2018 (15.02.2018) W I P0 I P C T (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) (72) (74) (81) Designated States International Patent Classification: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, C07K 14/31 (2006.01) CO7K 1/22 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PCT/EP2017/069976 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 07 August 2017 (07.08.2017) (84) Designated States (unless otherwise indicated, for every English kind of regional protection available): ARIPO (BW, GH, English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Priority Data: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 16183710.9 11 August 2016 (11.08.2016) EP EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 16205707.9 21 December 2016 (21.12.2016) EP MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Applicant: NAVIGO PROTEINS GMBH [DE/DE]; KM, ML, MR, NE, SN, TD, TG). Heinrich Damerow Str. 1, 06120 Halle/Saale (DE). Inventors: KNICK, Paul; Navigo Proteins GmbH Hein- Published: rich-Damerow-Str. 1, 06120 Halle/Saale (DE). FIEDLER, — with international search report (Art. 21(3)) Erik; Navigo Proteins GmbH Heinrich Damerow Str. 1, — before the expiration of the time limit for amending the 06120 Halle/Saale (DE). HAUPTS, Ulrich; Navigo Pro- claims and to be republished in the event of receipt of teins GmbH Heinrich Damerow Str. 1, 06120 Halle/Saale amendments (Rule 48.2(h)) (DE). MEYSING, Maren; Navigo Proteins GmbH Hein- — with sequence listing part of description (Rule 5.2(a)) rich-Damerow-Str. 1, 06120 Halle/Saale (DE). Agent: HAUCKE, Kerstin; Navigo Proteins GmbH Hein- rich Damerow Str. 1, 06120 Halle/Saale (DE). (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Title: NOVEL ALKALINE STABLE IMMUNOGLOBULIN-BINDING PROTEINS : The present invention relates to immunoglobulin (Ig) binding proteins comprising amino acids selected from the group consisting at least of 1I, 11A, 11E, 11I, 35R, 35I, and matrices comprising the Ig binding proteins of the invention. The invention also relates affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification the invention. FIG. 4. cs27 with at least 11, 11A, 35R 250 200 at c 150 t 100 T < 50 I I827 cs27-1 cs27-2 one or more Ig binding domains 42L. The invention further relates to to a use of these Ig binding5 proteins using the Ig binding proteins = (54) 11 Ir ----- ir) 1-1 cT ei © p i p (57) - with 0 el affinity or 0 of