baber/WOPTO huggingface dataset:
Patent CA-2724785-A1 (CA)
Title: Selective caspase inhibitors and uses thereof
Inventor: AHLFORS JAN-ERIC
IPC: C07K5/10
Filed: 2009-05-21
Abstract: The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).
Patent CA-2726028-A1 (CA)
Title: Method for electrochemically identifying target nucleotide sequences
Inventor: LIMOGES BENOIT
IPC: C12Q1/68
Filed: 2009-06-04
Abstract: The invention relates to a method and assembly for electrochemically identifying target nucleotide sequences. The method comprises the following steps consisting of: supplying a biological sample that may contain a predetermined target nucleotide sequence; supplying activatable amplification means comprising free nucleotides in order to form replicated target nucleotide sequences; supplying an oxido-reducible compound capable of being inserted during replication between the nucleotides forming the replicated target sequences; and activating the activatable amplification means before applying an electric field to the sample in order to activate the oxido-reducible compound. Said replicated target sequences then cause the inhibition of the electrochemical activity of the inserted oxido-reducible compound, and the presence of the predetermined target nucleotide sequence is determined if the electric current decreases.
Patent CA-2728276-A1 (CA)
Title: Combination therapies against cancer
Inventor: VON STEIN OLIVER
IPC: A61P35/00
Filed: 2009-06-18
Abstract: Specific oligonucleotide sequences, when given subcutaneously and in particular when administered on a mucous membrane, e.g. intranasally, intravaginally, or rectally, have a profound effect on various human cancer forms as confirmed in vivo, in animal studies, and in vitro, in human PBMCs collected from blood from healthy subjects and from patients suffering from CLL. The compounds are also preferably used in combination with a cancer therapy chosen among radiation treatment, hor-mone treatment, surgical intervention, chemotherapy, immunological therapies, photodynamic therapy, laser therapy, hyperther-mia, cryotherapy, angiogenesis inhibition, or a combination of any of these, and most preferably an immunological treatment com-prising the administration of an antibody to the patient.
Patent CA-2734321-A1 (CA)
Inventor: BUZATU DAN A
IPC: G01N35/08
Filed: 2009-08-17
Abstract: In various embodiments, the present disclosure describes methods and systems for detecting microbes in a sample. The methods are generally applicable to quantifying the number of target bacteria in a sample counted from a detection region of a flow cytometer histogram. The detection methods can be employed in the presence of other microorganisms and other non-target microbe components to selectively quantify the amount of a target microbe.    The methods are advantageous over those presently existing for testing of foodstuffs and diagnostic evaluation in their speed, accuracy and ease of use. Various swab collection devices and kits useful for practicing the present disclosure are also described herein.
Patent CA-2735484-A1 (CA)
Title: Walk-behind lawnmower height adjusting mechanism
Inventor: NINOMIYA YUSUKE
IPC: A01D34/67
Filed: 2011-03-28
Abstract: A walk-behind lawnmower having a height adjusting mechanism for adjusting the height of a housing above the ground. The height adjusting mechanism includes: a front wheel supporting member and a rear wheel supporting member that are attached to the housing so as to be capable of swinging up and down; a linking member for linking the front and rear wheel supporting members so as to be capable of concerted motion; and a locking mechanism for restricting and releasing displacement of the linking member in the forward-and-backward direction. The locking mechanism includes: a plurality of locking grooves arranged in a row from front to rear on the linking member; a locking pin capable of selectively interlocking with one of the locking grooves; a pin-guiding part for guiding the locking pin to be capable of entering into and retracting from one of the locking grooves; and an operating member for sliding and operating the locking pin.
Patent CA-2737431-A1 (CA)
Inventor: OOKUBO TOMOHIRO
IPC: A61K31/27
Filed: 2009-09-17
Abstract: Disclosed is a novel amino acid derivative having excellent analgesic activity. The amino acid derivative is a novel compound which exhibits excellent analgesic activity not only with respect to nociceptive pain model animals, but also with respect to neuropathic pain model animals, and is extremely useful as a medical agent for the treatment of various painful conditions that exhibit acute or chronic pain or neuropathic pain.
Patent CA-2741511-A1 (CA)
Inventor: YAMAGISHI TATSUYA
IPC: A61K31/5377
Filed: 2009-11-24
Abstract: Disclosed is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a selective antagonist of a 5-HT2B receptor.  The compound and salt are useful for treatment or prevention of various diseases and conditions associated with a 5-HT2B receptor.     (see formula I)
Patent CA-2745121-A1 (CA)
Inventor: NISHIDA HIDEMITSU
IPC: C07D265/32
Filed: 2009-12-03
Abstract: The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said com-pounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
Patent CA-2746721-A1 (CA)
Inventor: MCKENZIE MARTIN
IPC: E21B33/00
Filed: 2009-12-23
Abstract: A device to provide a seal between a housing(ll) for a moving element (10) such as a drill chain, piston or the like and the moving element. The device comprising a storage well (13) to retain seal material, the storage well having an outlet connecting with an aperture in a housing enabling seal material to flow into the space between a housing and the moving element and form a seal, the device further including an inlet port (16) enabling seal material precursor to be added into the storage well, newline pressurising means to pressurise the seal material precursor and force it out of the aperture.
Patent CA-2748080-A1 (CA)
Inventor: WILLIAMS MICHAEL JAMES
IPC: H04L9/32
Filed: 2011-08-05
Abstract: A system and method is provided for a computer-aided telephone interview system that includes a computer server operatively connected to an interviewer over a global telecommunications network, where the server is configured to transmit sound file prompts that can include pre-recorded questions and statements to a person being interviewed over a telephone network under the control of the interviewer in response to answers provided by the person being interviewed.
Patent CA-2751707-A1 (CA)
Inventor: DEMPSKI KELLY L
IPC: G06F3/042
Filed: 2006-11-17
Abstract: Complex collaboration or decision support applications perform complex design or planning tasks, often with the input of large groups of people over long periods of time. The combination of time and complexity often obscures past actions, making it difficult to remember factors that influenced earlier stages of the planning task. This is especially true if the task involves many people working concurrently and at different times. When groups of people collaborate concurrently, detecting and tracking multiple simultaneous touches or movements by a user or user tool, on or near a surface (e.g., on a planar surface) is an essential capability. The multiple target detection and application state navigation system provides an application- independent mechanism that allows operators to operate an application in real-time, and walk back through the history of the application in order to better understand (or remember) the application actions that were taken in the past and the triggers for those actions.
Patent CA-2755321-A1 (CA)
Inventor: CHANG JOHN Y
IPC: A61M25/10
Filed: 2010-03-18
Abstract: A guide catheter (601) for use in treating sinuses, the catheter including a catheter shaft (610) configured to provide suction about a balloon catheter and a distal portion shaped for navigating body anatomy. In one embodiment, the guide catheter includes a valve (624) for sealing the balloon catheter and a vent (628) for controlling suction.
Patent CA-2755515-A1 (CA)
Inventor: CHENG WEIGUO
IPC: D21H17/67
Filed: 2010-04-14
Abstract: A method of preparing a stable dispersion of flocculated filler particles for use in papermaking processes comprises sequential addition of a first flocculating agent to an aqueous dispersion of filler particles followed by shearing of the dispersion, followed by addition of a second flocculating agent to the dispersion and further shearing of the resultant filler flocs to the desired particle size resulting in shear resistant filler flocs with a defined and controllable size distribution. In addition, a neutralizing coagulant can be added to the dispersion to partially or completely neutralize the charge of the filler before the first flocculating agent is added
Patent CA-2756021-A1 (CA)
Inventor: LOS PRZEMYSLAW
IPC: C25C5/02
Filed: 2010-03-17
Abstract: The method for obtaining copper powders and nanopowders from industrial electrolytes including waste industrial electrolytes through electrochemical deposition of metallic copper on a cathode consists in using potentiostatic pulse electrolysis without the current direction change or with the current direction change, using the cathode potential value close to the plateau or on the plateau of the current voltage curve on which the plateau of the current potential range is from -0.2 V ÷ -1 V, and a move-able or static ultramicroelectrode or an array of ultramicroelectrodes made of gold, platinum or stainless steel wire or foil is used as a cathode, whereas metallic copper is used as an anode and the process is carried out at temperature from 18-60°C, and the electrolysis lasts from 0.005 to 60 s. Said method can be used to obtain nanopowders and powders characterised by particle struc-ture and dimension repeatability and purity from 99% + to 99.999% from waste industrial electrolytes and wastewaters from cop-per industry and electroplating plants without additional treatment.
Patent CA-2756053-A1 (CA)
Title: Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents
Inventor: WONG CHI-HUEY
IPC: A61P31/16
Filed: 2009-07-10
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (.alpha.- GalCer) analogs, and their use as immunotherapies, adju-vants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cy-tokine response in a subject includes administer-ing an effective amount of a compound to a sub-ject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the com-pound and the antigen-presenting cell, wherein the formation of the complex results in the activa-tion of a receptor on the lymphocyte; and activat-ing the lymphocyte to produce the cytokine re-sponse.
Patent CA-2761784-A1 (CA)
Inventor: BONNIN THIERRY
IPC: G06F3/01
Filed: 2010-05-07
Abstract: Une paire de lunettes ophtalmiques est adaptée pour caractériser une direction de regard d'un porteur. Chaque verre (1, 2) de la paire de lunettes est muni de sections de sortie pour diriger un rayonnement vers des zones oculaires (ZD1, ZG1, ZD2, ZG2) du porteur, où se déplacent des portions différentes d'un limbe oculaire (L) dudit porteur. Ledit verre est muni en outre de sections d'entrée pour collecter des parties dudit rayonnement réfléchies dans lesdites zones oculaires. Une unité de calcul est aussi associée à la paire de lunettes, pour déterminer la direction de regard du porteur à partir de signaux de détection mesurant les parties de rayonnement qui sont collectées simultanément par les sections d'entrée des deux verres.
Patent CA-2763358-A1 (CA)
Title: Valve release mechanism
Inventor: SIMPSON GREGORY D
IPC: F16K17/36
Filed: 2012-01-05
Abstract: A valve release mechanism has an actuator, a ring, a plurality of ball bearings, and a retainer. The retainer is positioned adjacent an inner diameter of the ring and has a plurality of circumferentially spaced holes therein. Each circumferentially spaced hole receives one of the plurality of ball bearings, which are movable therein. The ring has channels and lands along its inner diameter that allow the ball bearings to move varying distances relative to the retainer. The lands contact the ball bearings when the ring is in a first position and the channels receive the ball bearings when the ring is in a second position. The poppet has a groove that is vertically aligned with circumferentially spaced holes in the retainer when the poppet is in a first closed position. The ball bearings are pressed into the groove in the poppet by the lands of the ring. The resulting interference of the ball bearings with poppet locks the poppet in the first closed position. The ring can be moved from the first closed position to a second position by the actuator.
Patent CA-2764199-A1 (CA)
Inventor: MERO TIMO
IPC: F23H15/00
Filed: 2012-01-16
Abstract: A boiler grate is provided, which comprises: air channels for supplying primary air to a furnace of a boiler; at least one channel, which is open on top, whereby the channel is arranged to collect ash and material from the furnace; and at least one as removal means, which is placed in said channel and arranged to move ash and material mechanically along the channel. In addition, a boiler is provided, which comprises said grate; a furnace, which is limited by the walls of the furnace and said grate; and an ash chute, which is arranged to remove ash and material from the furnace. The ash removal means is arranged to move ash and material towards the air chute. In an example the grate comprises a set of air nozzles, which are arranged to supply primary air into the furnace; and the channel is placed between the air nozzles.
Patent CA-2765487-A1 (CA)
Title: Process for the manufacture of halogenated precursors of alkenones under specific conditions
Inventor: BRAUN MAX
IPC: C07C49/175
Filed: 2010-07-05
Abstract: The invention relates to a process for preparing a halogenated precursor of an alkenone, which comprises reacting a carboxylic acid halide with a vinyl ether in a liquid reaction medium under turbulent conditions. The invention also relates to a process for preparing an alkenone, by eliminating hydrogen halide from said precursor to form the alkenone.
Patent CA-2765757-A1 (CA)
Title: Electrical discharge acoustic source with bank of capacitors
Inventor: DYER BEN
IPC: G01V1/157
Filed: 2010-06-14
Abstract: An electrical discharge acoustic source 16 comprises a power section 18, a control section 30, a bank of capacitors 24, and a discharge electrode arrangement 28; wherein the bank of capacitors 24 further comprises a switching arrangement 26 by which each capacitor in the bank 24 is independently connectable to an electrode in the discharge electrode arrangement 28 so as to provide a predetermined acoustic signal on operation of the discharge electrode arrangement 28. A method of generating an acoustic signal comprises independently configuring the connection of each electrode in the discharge electrode arrangement 28, and discharging the connected capacitors through the discharge electrode arrangement 28 so as to provide a predetermined acoustic output.
Patent CA-2766161-A1 (CA)
Title: Scalable indexing in a non-uniform access memory
Inventor: BOWDEN PAUL
IPC: G06F17/30
Filed: 2010-06-25
Abstract: Method and apparatus for constructing an index that scales to a large number of records and provides a high transaction rate. New data structures and methods are provided to ensure that an indexing algorithm performs in a way that is natural (efficient) to the algorithm, while a non-uniform access memory device sees IO (input/output) traffic that is efficient for the memory device. One data structure, a translation table, is created that maps logical buckets as viewed by the indexing algorithm to physical buckets on the memory device. This mapping is such that write performance to non¬ uniform access SSD and flash devices is enhanced. Another data structure, an associative cache is used to collect buckets and write them out sequentially to the memory device as large sequential writes. Methods are used to populate the cache with buckets (of records) that are required by the indexing algorithm. Additional buckets may be read from the memory device to cache during a demand read, or by a scavenging process, to facilitate the generation of free erase blocks.
Patent CA-2767832-A1 (CA)
Inventor: RANKIN ROBIN CUNNINGHAM
IPC: A45C13/20
Filed: 2012-02-14
Abstract: Systems to attach together bags having various types of rolling members are described. In a system for attaching at least two bags, each having at least two spinner wheels, a front face, a back face and a bottom face, the improvement comprising at least one attachment member located on each of the at least two bags for attaching said bags when engaged such that the at least two bags are capable of rolling together. A bag embodying the features of the improvement is described. Different attachment members are described for the system and bag, including magnets, hook-and-loop fasteners, clips, buckles, straps, adhesive tape, hooks and buttons.  Different configurations for the attached bags are described, including "front-to-front", "back-to-front"  and "side-by-side" configurations. Bags having rolling members other than spinner wheels are described, including ball transfer units and ball bearings.
Patent CA-2768380-A1 (CA)
Title: Device for forming deep-drawn containers
Inventor: VERBEEK DICK CORNELIS
IPC: B21D22/21
Filed: 2010-07-06
Abstract: The invention relates to a device (40) for forming deep-drawn containers (1), having a mold (41) of conical shape interacting with a stamping body (10; 20; 30), which operatively connects with a material web (2) when the stamping body (10; 20; 30) is immersed in the mold (41), wherein at least at its outer periphery, wherein the stamping body (10; 20; 30) is made of an elastic material, and wherein on the side facing the material web (2), the stamping body (10; 20; 30) has a shape, the conicity of which is less than the conicity of the mold (41). According to the invention, it is provided that the stamping body (10; 20; 30) is slightly smaller than the opening region (45) of the mold, and that, when completely immersed in the mold (41), the stamping body (10; 20; 30) has a clearance (44) to the material web (2), at least in the later peripheral area (5) of the container (1).
Patent CA-2770383-A1 (CA)
Inventor: HANAWA TATSUYA
IPC: B29C70/06
Filed: 2010-10-13
Abstract: L'invention porte sur un procédé pour fabriquer un élément poutre formé de : une base renforcée de fibre qui comprend, en coupe transversale orthogonale à la direction longitudinale de l'élément poutre, une section âme et au moins deux sections ailes qui partent de la section âme vers les deux cotés par l'intermédiaire d'au moins une section embranchement ; et un corps en forme de charge chargé dans le vide en forme de coin formé dans la section embranchement. L'invention porte plus précisément sur un procédé pour fabriquer un élément poutre dans lequel, afin de fabriquer en continu et avec un bon rendement le corps en forme de charge qui doit être chargé dans le vide, même si la section transversale du vide en forme de coin varie dans la direction longitudinale de la poutre, le corps en forme de charge est fabriqué au moins par les opérations de fabrication suivantes (A) à (C). (A) Une opération d'acheminement d'une matière de remplissage faite d'une fibre renforcée (B) Une opération de compression de la matière de remplissage au moyen d'un moule de préformage pour donner à l'objet préformé en forme de charge une section de saillie en forme de coin (C) Une opération d'enfoncement de l'objet préformé en forme de charge dans le vide et de compression de l'objet préformé en forme de charge pour le déformer, en réalisant par ce moyen le corps en forme de charge
Patent CA-2771187-A1 (CA)
Inventor: PARK ANTHONY NEAL
IPC: H04J1/16
Filed: 2010-08-17
Abstract: One embodiment of the invention sets forth an encoding server including components configured to encode a video stream associated with a content title for adaptive streaming. The video stream is first processed by a VC1 encoder to generate an encoded video stream comprising a multiple GOPs, each GOP including a key frame and having a different playback offset. The encoded video stream is then packaged such that the GOPs are stored in data packets of the packaged encoded stream. An SHI generator generates an SHI associated with the packaged encoded stream that includes a switch point associated with each GOP. Each switch point includes the playback offset associated with the corresponding GOP and the data packet storing the key frame of the corresponding GOP. The SHI associated with multiple packaged encoded video streams associated with the same content title and encoded to different playback bit rates have corresponding switch points.
Patent CA-2778284-A1 (CA)
Inventor: OZCAN AYDOGAN
IPC: G01N21/64
Filed: 2010-10-19
Abstract: A system for imaging a cytological sample includes a sample holder configured to hold a cytological sample. A spatial filter is disposed at a distance z1 from the sample holder on first side of the sample holder, the spatial filter having an aperture disposed therein configured to allow the passage of illumination. An imaging sensor array is disposed at a distance z2 from the sample holder on a second, opposite side of the sample holder. An illumination source is configured to illuminate the cytological sample through the aperture, the spatial filter being interposed between the illumination source and the sample holder.
Patent CA-2778742-A1 (CA)
Inventor: KOPP ROBERT G
IPC: A63B9/00
Filed: 2012-06-01
Abstract: A hybrid play set is disclosed which includes twin towers. Each of the towers includes at least two levels. A play house and an enclosed area can be provided within one tower. A sand box, a ladder, a slide and a climbing wall can be provided within the other tower. A swing set is also secured to one side of one of the towers. The components from which the play set is made can be plow molded plastic, wood or a composite of blow molded plastic and wood/metal reinforcement.
Patent CA-2779439-A1 (CA)
Inventor: HUTTS DAVID JEROME
IPC: B29C49/06
Filed: 2009-11-06
Abstract: The present invention relates to a plastic preform (1) for a container comprising at least one elongate protrusion (10, 12, 13, 14, 15) and/or groove (20), which is obtained by injection moulding. The present invention further relates to a container blow-moulded from such a preform comprising at least one longitudinal protrusion (32, 33, 34) and/or groove and having a continuous inner and outer surface.