baber/WOPTO huggingface dataset:
Patent CY-1119822-T1 (CY)
Inventor: REED STEVEN G
IPC: A61K39/39
Filed: 2018-01-24
Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogenous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
Patent CY-1120005-T1 (CY)
Title: Συνεχης χορηγηση αναστολεων l-ντοπα, αποκαρβοξυλασης ντοπα, αναστολεων κατεχολ-ο-μεθυλ τρανσφερασης και συνθεσεις αυτων
Inventor: YACOBY-ZEEVI ORON
IPC: A61P25/16
Filed: 2018-03-06
Abstract: Στο παρόν παρέχεται, εν μέρει, μέθοδος θεραπείας νευρολογικής ή κινητικής διαταραχής σε έναν ασθενή που έχει ανάγκη αυτής, που περιλαμβάνει υποδόρια χορήγηση στον εν λόγω ασθενή φαρμακευτικώς αποδεκτής σύνθεσης περιέχουσας λεβοντόπα και προαιρετικώς καρβιντόπα και προαιρετικώς εντακαπόνη ή τολκαπόνη ή φαρμακευτικώς αποδεκτά άλατα αυτών, όπου η εν λόγω σύνθεση χορηγείται ουσιαστικώς συνεχώς και συνθέσεις που μπορεί να χρησιμοποιηθούν στις αποκαλυπτόμενες μεθόδους.
Patent CY-1121301-T1 (CY)
Title: Πολλαπλης φασης καψουλες μαλακης πηκτης, συσκευη και μεθοδος αυτων
Inventor: DRAPER PETER
IPC: A61K9/48
Filed: 2018-12-21
Abstract: Πολλαπλής φάσεως μαλακής ζελατίνας μορφή δοσολογίας που περιλαμβάνει τουλάχιστον μία προδιαμορφωμένη στερεά μορφή δοσολογίας και τουλάχιστον μία υγρή φάση πλήρωσης. Οι πολλαπλής φάσης μαλακής ζελατίνας μορφές δοσολογίας της παρούσας εφεύρεσης είναι ιδιαιτέρως χρήσιμες για να συνδυάζουν τουλάχιστον μία στερεά μορφή δοσολογίας και τουλάχιστον μία υγρή φάση για απλή κατάποση. Επίσης περιγράφονται μέθοδος και συσκευή για βιομηχανική κατασκευή των πολλαπλής φάσεως μαλακής ζελατίνης μορφών δοσολογίας. Η στερεά φάση, η υγρή φάση ή οι επικαλύψεις μπορεί να περιλαμβάνουν δραστικά φαρμακευτικά συστατικά, φαρμακοδιατροφικά, διατροφικά συμπληρώματα, θεραπευτικές ουσίες, λειτουργικά έκδοχα ή συνδυασμούς αυτών.
Patent CY-1123278-T1 (CY)
Title: Θαλασσιο συστημα για τη μεταφορα και τη διανομη υγροποιημενου φυσικου αεριου lng
Inventor: DUVISON SANTIAGO MIGUEL
IPC: B63B35/28
Filed: 2020-03-30
Abstract: Η παρούσα εφεύρεση αναφέρεται σε ένα θαλάσσιο σύστημα για τη μεταφορά και τη διανομή υγροποιημένου φυσικού αερίου LNG που περιλαμβάνει μια μεγάλη μονάδα τροφοδοσίας LNG, τουλάχιστο ένα μικρό δεξαμενόπλοιο LNG (16), το οποίο λαμβάνει μια τροφοδοσία υγροποιημένου φυσικού αερίου LNG από τη μεγάλη μονάδα τροφοδοσίας LNG, μια τουλάχιστο φορτηγίδα μεταφοράς βυτιοφόρων οχημάτων (17), η οποία φορτηγίδα έχει μέσα πρόσβασης βυτιοφόρων οχημάτων σε φορτηγίδα και μέσα εξόδου, όπου η φορτηγίδα μεταφοράς βυτιοφόρων οχημάτων κινείται μεταξύ του μικρού δεξαμενόπλοιου μεταφοράς και διανομής LNG (16) και του λιμανιού (19), όπου η διαμορφωμένη αποβάθρα προς την ακτή διευκολύνει την αναχώρηση και την επιστροφή του βυτιοφόρων οχημάτων (18) για διανομή του LNG στους τελικούς πελάτες.
Patent CY-1124660-T1 (CY)
Title: Μη επανδρωμενη ή με εξ αποστασεως λειτουργια πλατφορμα
Inventor: ENGENE KNUT
IPC: E02B17/02
Filed: 2020-10-29
Abstract: Παρουσιάζεται μια μη επανδρωμένη πλατφόρμα πετρελαιοπηγής (1) (UWP), η οποία αποτελείται από ένα χωροδικτύωμα (10) που σχεδιάζεται και προσαρμόζεται ώστε να στηρίζεται στον πυθμένα της θάλασσας. Η μη επανδρωμένη πλατφόρμα πετρελαιοπηγής (1) περιλαμβάνει μια υπερκατασκευή που εγκαθίστανται στην κορυφή του χωροδικτυώματος (10). Η υπερκατασκευή σχεδιάζεται ως τυποποιημένη δομή βάσης σχεδιασμένη για μελλοντικές δομές υπερκατασκευών πολλαπλών χρήσεων (3). Κάθε δομή υπερκατασκευής (3) προσαρμόζεται στον αριθμό των πετρελαιοπηγών που θα αναπτυχθούν. Η δομή υπερκατασκευής (3) κατασκευάζεται από έναν αριθμό διαφορετικών αλλά τυποποιημένων τμημάτων (4). Κάθε τυποποιημένο τμήμα (4) προορίζεται για έναν συγκεκριμένο και προκαθορισμένο σκοπό και θέση στην δομή υπερκατασκευής (3).
Patent CY-1123638-T1 (CY)
Title: Σωληνες εκκενωσης αεριων
Inventor: ROZMAN ROBERT
IPC: H01T2/02
Filed: 2020-12-21
Abstract: Ένας σωλήνας εκκένωσης αερίων περιλαμβάνει ένα περίβλημα το οποίο ορίζει έναν θάλαμο, πρώτο και δεύτερο τερματικό ηλεκτρόδιο τοποθετημένα επάνω στο περίβλημα, μια πληθώρα εσωτερικών ηλεκτροδίων που εντοπίζονται στον θάλαμο, και ένα αέριο που περιέχεται στον θάλαμο. Τα εσωτερικά ηλεκτρόδια διευθετούνται σειριακώς στον θάλαμο σε σχέση απόστασης μεταξύ τους για να ορίσουν μια σειρά από διάκενα σπινθήρα από το πρώτο τερματικό ηλεκτρόδιο έως το δεύτερο τερματικό ηλεκτρόδιο. Ο θάλαμος είναι ερμητικά σφραγισμένος.
Patent GR-970300008-T1 (GR)
Title: Layered element for the absorption of liquids
Inventor: BRUEGGEMANN HELMUT
IPC: A61F13/53
Filed: 1997-04-30
Abstract: The present invention relates to layered bodies consisting of at least one plastic foam and/or latex foam layer and particulate, superabsorbent polymers for the absorption of water and aqueous liquids, which bodies comprise the superabsorber on, between, or below the foamed plastic and/or latex layer in a quantitatively and/or locally predetermined and fixed areal configuration at a quantity ratio of plastic and/or latex foam to the superabsorber of 1:500 to 50:1. The plastic/latex foam may comprise fillers, pigments and/or synthetic fibers. The layered bodies have an increased absorption capacity for water and aqueous liquids; in particular under load. They are manufactured by spreading out the foam, applying the superabsorber in the predetermined quantity ratio, optionally by using a stencil, and by fixing it by means of a heat treatment. These layered bodies are used in hygienic articles, as components in natural or artificial soils, as insulating material for pipes and ducts, primarily for cables and constructional elements, as liquid-absorbing and liquid-storing component in packaging materials, and as a part in garments.
Patent HR-P20110009-T1 (HR)
Inventor: YAMAZAKI YUKIYOSHI
IPC: A61K31/4439
Filed: 2011-01-07
Abstract: Spoj predstavljen sljedećom formulom (1) naznačen time, dasvaki od R1 i R2, koji mogu biti identični ili međusobno različiti, predstavlja atom vodika, metilnu skupinu ili etilnu skupinu; svaki od R3a, R3b, R4a i R4b, koji mogu biti identični ili međusobno različiti, predstavlja atom vodika, atom halogena, nitro skupinu, hidroksilnu skupinu, C1-4 alkilnu skupina, trifluorometilnu skupinu, C1-4 alkoksi skupinu, C1-4 alkilkarboniloksi skupinu, di-C1-4 alkilamino skupinu, C1-4 alkilsulfoniloksi skupinu, C1-4 alkilsulfonilnu skupinu, C1-4 alkilsulfinilnu skupinu ili C1-4 alkiltio skupinu, ili R3a i R3b, ili R4a i R4b mogu biti povezani tako da tvore alkilendioksi skupinu; X predstavlja atom kisika, atom sumpora ili N-R5 (R5 predstavlja atom vodika, C1-4 alkilnu skupinu, C1-4 alkilsulfonilnu skupinu ili C1-4 alkiloksikarbonilnu skupinu); Y predstavlja atoma kisika, S(O)1 (1 je broj u rasponu od 0 do 2), karbonilnu skupinu, karbonilamino skupinu, aminokarbonilnu skupinu, sulfonilamino skupinu, aminosulfonilnu skupinu ili NH; Z predstavlja CH ili N; n je broj u rasponu od 1 do 6; a m je broj u rasponu od 2 do 6, ili njegove soli. Patent sadrži još 11 patentnih zahtjeva.
Patent HR-P20110697-T1 (HR)
Inventor: POLLENTIER STEPHANE
IPC: A61P15/00
Filed: 2011-09-29
Abstract: Uporaba, naznačena time, da se koristi flibanserin, po izboru u obliku slobodne baze, farmakološki prihvatljivih kiselinskih adicijskih soli i/ili po izboru u obliku svojih hidrata i/ili solvata za izradu lijeka za liječenje poremećaja seksualne želje u pre-menopauzi kod žena, pri čemu se lijek primjenjuje jednom dnevno uzastopno tijekom određenog vremenskog razdoblja. Patent sadrži još 13 patentnih zahtjeva.
Patent SI-1428780-T1 (SI)
Title: Device for feeding of film for the production of film bags and device for the production of film bags
Inventor: WILD HANS-PETER DR
IPC: B65B41/16
Filed: 2002-12-02
Abstract: Device (1) for feeding foil (2) comprises at least one driven supply roll holder (3), at least one conveying device (4), and at least one foil sensor device (6) arranged between the supply roll holder and the conveying device and having at least one fixed deviating roller (7) and first and second jockey rollers (8, 9) mounted in moving bearings (10, 11). The bearings of the jockey rollers are suspended on at least one flexible suspending device (12) guided via a deviating wheel (13, 14) and are coupled to each other so that the weight of the jockey rollers is at least partly compensated.  An Independent claim is also included for a device used in the manufacture of foil bags comprising a welding device for welding at least two foils and at least two devices for feeding the two foils.
Patent SI-1340667-T1 (SI)
Title: Device for picking and carrying at least a functional element of a technical installation
Inventor: VON SEGGERN JORG
IPC: B62B3/00
Filed: 2003-02-28
Abstract: The device for the holding and/or transporting of at least one functional component has at least one holding element (11,12) and a chassis with at least one wheel (6,9) vertically adjustable. The chassis may have at least three wheels and all of them may be vertically adjustable. The chassis is formed as a profiled construction (1) and has at least one freely extending profile (5) orientated approximately parallel to the ground (4) and with a wheel fitted at the end.
Patent SI-1714194-T1 (SI)
Title: Metal identification platelet and method of producing thereof
Inventor: JERMOLAJEV IGOR
IPC: G03H1/00
Filed: 2004-12-02
Abstract: A metal identification platelet (1) equipped with an identification code, while the identification code comprises a hologram (2). A method of producing the identification platelet (1) with the identification code, comprising the following steps: A shield (9) from an electro-insulation material is formed on a shim (4) with a holographic motif (7). Then, the shim (4) is galvanized in the places not covered by the shield (9) from the electro-insulation material. And the completed metal identification platelets (1) are removed from the shim (4).
Patent SI-1747002-T1 (SI)
Title: New apiary veterinary composition
Inventor: ORBAN GYULA
IPC: A61K31/00
Filed: 2005-05-13
Abstract: The present invention concerns veterinary compositions for the treatment and/or prevention of nosema disease (Nosemosis apium) in honey bees comprising 2-hydroxy-benzoic acid (salicylic acid) or 2-(acetyloxy)benzoic acid (acetyl-salicylic acid) or their salt(s) as an active ingredient. In one embodiment, a composition contains sugar-industry molasses (concentrated watery extract of Beta vulgaris cv altissima) as a carrier and, if desired, any other auxiliary and carrier substances.
Patent SI-1885753-T1 (SI)
Title: Production of recombinant Il-18 binding protein
Inventor: WEBER URS
IPC: C12P21/02
Filed: 2006-06-01
Abstract: The invention relates to a process for the production of IL-18 binding protein (IL-18BP), and to a composition comprising IL-18BP characterized by a specific glycosylation pattern.
Patent SI-2178811-T1 (SI)
Title: Granule coated with urethane resin
Inventor: WATANABE ATSUSHI
IPC: C05G3/00
Filed: 2007-08-13
Abstract: A coated granule obtained by coating a bioactive substance-containing granule with a urethane resin obtained by reaction of an aromatic polyisocyanate with an alcohol mixture comprising a polyesterpolyol having 15 wt % or more of an oxycarbonyl structure (—O—C(═O)—) part in the molecule and a C4-C30 alkanol optionally substituted by one or more aryl groups, wherein the molar ratio of the polyesterpolyol to the alkanol is 1:1 to 100:1, is capable of controlling elution of the bioactive substance appropriately, and, the urethane resin forming the coat film shows degradability in soil.
Patent SI-2117944-T1 (SI)
Title: Container
Inventor: BLUMENSCHEIN MARCUS
IPC: B65D21/02
Filed: 2008-02-11
Abstract: The invention relates to a container (1) comprising a container wall (2), a container base (3) and a container opening (4), the container wall (2) extending in a substantially conically manner from the base to the opening and the inner face of the container wall (2) having spaced stacking ribs (5) running axially around the circumference. According to the invention, the container is developed in that the outer radial region of the exterior of the container base (3) is provided with at least one cavity (10), into which at least one stacking rib of a container (1) located below can engage when several containers (1) are stacked inside one another, thus fixing the containers (1) and preventing them from rotating in relation to one another. This improves the positional stability of the stacked containers.
Patent SI-2338093-T1 (SI)
Title: A control valve
Inventor: JORGENSEN AGNES
IPC: G05D7/00
Filed: 2009-05-04
Abstract: A control valve comprises a valve housing (1) having an inlet side (17) and an outlet side (18). The control valve also has a pressure maintaining arrangement for maintaining a constant differential pressure between the inlet and outlet sides, as well as an amount control arrangement for setting the maximum flow through the valve. A pair of cylinder shells located in the flow path have cooperating recesses which provide an uncovered area forming an opening (25). One cylinder shell is rotatable relative to the other cylinder shell by a rotatable handle (13), whereby a larger or smaller opening (25) between the cooperating cylinder shells may be provided. Both cylinder shells are axially displaceable within a seat hole (8), resulting in an increase or a decrease of the opening (25).
Patent SI-3095748-T1 (SI)
Title: Winch with a safety mechanism for switching off winding of a rope
Inventor: PISEK FRANC
IPC: B66D1/00
Filed: 2015-07-17
Abstract: Winch with a safety mechanism for switching off winding of a rope, is that switching off of the end switch (10) releases a pushing (5) element, which is pushed into the end switch by a rotatably mounted washer (6) on an accessory (3a) on a rope guide, when the accessory of an end piece due to winding of the pulling rope reaches the washer and pushes it into its final position. The mechanism may be installed in winches with electric, hydraulic or mechanic steering of winding and unwinding of the pulling rope.
Patent TR-201000158-T1 (TR)
Title: Bir destek elemanı.
Inventor: DOGAN BARIS
IPC: B21D39/06
Filed: 2008-06-23
Abstract: Bu buluş, U-profil (2) üzerine parçaların (4) daha verimli monte edilmesini sağlayan bir destek elemanı (1) ile ilgilidir.
Patent DE-3586543-T2 (DE)
Inventor: BENEDICT JAMES JOHN
IPC: C07F9/547
Filed: 1985-12-16
Granted: 1993-01-07
Abstract: Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate metabolism; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these novel cyclic diphosphonic acid compounds.
Patent DE-3650755-T2 (DE)
Inventor: VAN DER LELY CORNELIS
IPC: A01K13/00
Filed: 1986-01-15
Granted: 2001-12-06
Abstract: A device for automatically milking animals, such as cows, comprises a computer controlled milking machine with a milking unit (29) having a support (17) for teat cups (52). The support (17) comprises at least two supporting arms carrying the teat cups (52). These supporting arms are provided with hinging means (53, 55, 56) by means of which the teat cups (52) are movable with respect to the further part of the support (17).
Patent DE-3784074-T2 (DE)
Inventor: MILLAR D
IPC: A61B8/12
Filed: 1987-11-13
Granted: 1993-05-19
Abstract: A method and assembly for inserting a plurality of sensors into a biological fluid vessel for diagnosing the condition of the vessel or fluid. A pressure sensor is described which is particularly adapted for use with a steerable guidewire for selective positioning in the vessel. In one application, the method is used in coronary diagnosis, to determine the pressure gradient across a coronary valve or stenosis in the coronary arterial tree. In this method, a guiding catheter is percutaneously inserted with its distal end proximate the ostium. A guidewire is inserted through the guiding catheter and subselectively positioned in a region of interest in the coronary arterial tree. Multiple pressure sensors are then threaded down the guidewire and positioned in the region of interest. Advantageously, such pressure sensors are approximately 3 French in diameter, allowing multiple sensors to be threaded through the guiding catheter and positioned in the small arteries of the coronary arterial tree. Such pressure sensors can be used in conjunction with other sensors (e.g. temperature, pH, or Doppler sensors) and are useful in a variety of applications (e.g. venous, urinary tract, esophogeal). In one version of the assembly, an angioplasty catheter is fitted to the guidewire and a pressure sensor device having a small flexible catheter body is fitted to the guidewire such that inserting the angioplasty catheter into a blood vessel also pushes the pressure sensor device into the vessel.
Patent DE-3788668-T2 (DE)
Inventor: ABATE JOSEPH A
IPC: H01S3/23
Filed: 1987-04-14
Granted: 1994-08-11
Abstract: An x-ray lithography system is disclosed in which x-rays (56) are generated by directing a high energy laser beam against a metal target (26) to form an x-ray emitting plasma. The x-rays from the plasma are then directed through a mask towards a resist covered wafer (58) to cause a patterned exposure on the wafer resist coating. The mask, the portion of the target which the laser beam strikes and the portion of the wafer to be exposed are all within an evacuated chamber (22). The laser, prior to entering the chamber,is split into two separate beams (24, 24A), each of which are focused and directed through a window (70, 72) in the side of the chamber towards the same spot on the target. Apparatus, including an air bearing, seal and positioner, is provided to move the target at periodic intervals. Similar apparatus is provided to move the wafer from exposure section to exposure section. The laser beam system includes a face pumped laser beam amplifier (188) and unidirectional beam expanders (232, 280) to allow the maximum energy to be transferred to the laser beam by the amplifier. A series of two or more laser pulses are provided in order to maximize the energy obtained from the laser amplifier. A magnet (76) and a membrane (77) shield are also provided to prevent high energy particles and dust contaminants from the plasma from effecting the lithography process. A materials handling device (14) is provided for moving wafers, targets and masks and an alignment system operating within the evacuated chamber, positions of the wafer with respect to the mask prior to the exposure thereof.
Patent DE-3852082-T2 (DE)
Inventor: LEVINSON ARTHUR D
IPC: C12P21/00
Filed: 1988-09-12
Granted: 1995-05-04
Abstract: Viable cell proportions and total cell densities in recombinant eukaryotic cell cultures are increased by transfecting a eukaryotic host cell with nucleic acid encoding a desired polypeptide and with an oncogene. Transfectant cultures are screened thereafter for the expression of elevated quantities of the desired polypeptide as compared to expression from the parent host cell.
Patent DE-3852315-T2 (DE)
IPC: A63H3/36
Filed: 1988-08-24
Granted: 1995-05-24
Abstract: PCT No. PCT/AU88/00319 Sec. 371 Date Feb. 20, 1990 Sec. 102(e) Date Feb. 20, 1990 PCT Filed Aug. 24, 1988 PCT Pub. No. WO89/01812 PCT Pub. Date Mar. 9, 1989.The present invention provides a doll (10) which is arranged to be fed both liquids and non-liquids or solids. These are received in respective first and second chambers (20, 22). The present invention also provides a chamber pot (54) for a doll (10). Further, the present invention provides a casing (98) for enclosing or enveloping a doll (10) to simulate the womb. The present invention allows for a visual explanation of childbirth and childcare to be given to young children. This may be supplemented by instructions from another source, e.g. an adult or text.
Patent DE-3874656-T2 (DE)
Inventor: COFFEY G
IPC: A23L29/20
Filed: 1988-02-24
Granted: 1993-03-25
Abstract: A food thickening composition is described which substantially maintains the viscosity of food products when they are heated to elevated temperatures. The composition comprises specific methylcelluloses in combination with various food approved starches.
Patent DE-3880531-T2 (DE)
Inventor: GRENNER GERD
IPC: G01N33/53
Filed: 1988-03-02
Granted: 1993-09-09
Abstract: An element for analysis of a liquid sample including a capillary containing a fixed reagent in fluid communication with reagent reservoirs and a waste liquid reservoir. A sample introducing means is provided which permits analyte in a sample to interact with the fixed reagent. A labelled reagent is provided which interacts with either the fixed reagent or the analyte in a manner which permits detection of the concentration of analyte in the sample. The capillary, reagent reservoirs, waste liquid reservoir and the sample introducing means are arranged within a common housing so that reagent waste liquid need not be removed from the element.
Patent TR-199900405-T2 (TR)
Inventor: RENSSEN DICK MALTHE-S
IPC: C07C237/46
Filed: 1997-08-29
Abstract: The invention provides a process for the production of iohexol comprising reacting 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodophthalamide with a 2,3-dihydroxypropylating agent, the improvement comprising effecting that said process in the presence of a solvent comprising 2-methoxy-ethanol and, optionally, isopropanol.
Patent DE-60001978-T2 (DE)
Inventor: VAN GERWEN PETRONELLA
IPC: B65D33/24
Filed: 2000-09-29
Granted: 2003-12-04
Abstract: The invention relates to a tobacco pouch (1) provided with a front wall (2) and a back wall (4) manufactured from plastic film and with a flap (6) attached to the back wall (4). The tobacco pouch is further provided with connecting means for closing off the tobacco pouch by releasably connecting the flap to the front wall. The connecting means comprise a first part (12) which is connected to the flap (6) and a second part (14) which is connected to the front wall (2). One of the two parts is provided with hooks (18) which can be releasably fastened to co-operating means provided on the other of the two parts. The first and second parts (12, 14) consist of a strip-shaped area, the lengthwise direction (16, 22) of one of which is at least substantially directed parallel to the side edge (8) when the flap (6) is connected to the front wall (2).
Patent DE-60007074-T2 (DE)
Inventor: DADEY J
IPC: A61P31/18
Filed: 2000-01-12
Granted: 2004-09-16
Abstract: A sulfated phosphatidylinositol, pharmaceutical compositions containing a sulfated phosphatidylinositol, and the administration of a sulfated phosphatidylinositol or the pharmaceutical compositions to individuals are disclosed. A sulfated phosphatidylinositol can be used alone to elicit a pharmacologic response, or can be incorporated into a variety of pharmaceutical compositions, both liquid and solid, as a component of a drug delivery system for the administration of a therapeutic agent to an individual.