Patent SG-11201810286W-A (SG)
Title: Variable diameter bioreactors
Inventor: MIETZNER MICHAEL
IPC: C12M1/24
Filed: 2017-06-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number 0 (43) International Publication Date .....0\"\"\"1 WO 2017/223269 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12M 3/00 (2006.01) Cl 2M 1/24 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/038670 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 22 June 2017 (22.06.2017) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (30) Priority Data: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/354,216 24 June 2016 (24.06.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: LONZA LTD. [CH/CH]; Lonzastrasse, 3930 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Visp (CH). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: MIETZNER, Michael; 132 Tuck Drive, Fre- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, mont, New Hampshire 03044 (US). BERI, Rajesh; 14 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Magnolia Drive, Westford, Massachusetts 01886 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, GUNDERSON, Edward; 8 Lucas Pond Road, Notting- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ham, New Hampshire 03290 (US). KM, ML, MR, NE, SN, TD, TG). (74) Agent: LI, Anne E. H.; CROWELL & MORING LLP, = 1001 Pennsylvania Avenue, NW, Washington, District of = Columbia 20004 (US). = = (54) Title: VARIABLE DIAMETER BIOREACTORS = = = 1014 1014 (57) : A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic = = = 1011 having diameter that is 1000 material, and a second vessel section a second greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel. _— - = = = = = A 1012 1014 = -• 10108 , lolCA 1004 pq f : 1012 = - 11 C:r ; i 1012' 10100 ;1010D D3 i _ 02 1014 1002 1014 D1 1016 1012 ei ei N 1018 ei IN FIG. ,-, © ei 10 C [Continued on next page] WO 2017/223269 Al IMEDIMOMMIONMEMEEHOIIIMMEHOMEHOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) — as to the applicant's entitlement to claim the earlier application (Rule 4.17(iii)) priority of the Published: — with international search report (Art. 21(3))