baber/WOPTO huggingface dataset:
Patent WO-2022056332-A1 (WO)
Inventor: CLINGER JARED M
IPC: B01D15/22
Filed: 2021-09-10
Abstract: Affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3 are disclosed. A blend or combination of spherical inorganic particles having a nominal particle size from about 5 microns to about 20 microns may be utilized. Also, the devices have a hydraulic permeability from about 200 (X 10 -12  cm 2 )    to about 700 (X 10 -12  cm 2 ). The affinity chromatography devices have a dynamic binding capacity (DBC) greater than 35 mg/ml at 10% breakthrough at a residence time of 20 seconds. Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an operating pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices and manifolds in a parallel configuration are also disclosed.
Patent WO-2022076456-A1 (WO)
Inventor: CABLE CRAIG
IPC: A61F2/16
Filed: 2021-10-05
Abstract: L'Invention concerne des implants ophtalmiques comprenant un LIO ayant des haptiques et des dispositifs d'administration de médicament fixés aux haptiques. L'étendue la plus postérieure du dispositif d'administration de médicament est située à l'avant du bord postérieur ou du bord de barrière de PCO, du LIO. Dans d'autres configurations, les dispositifs d'administration de médicament sont pourvus de bords de barrière de PCO.
Patent WO-2022076650-A1 (WO)
Inventor: JOHNSON DAVID A
IPC: A61N1/32
Filed: 2021-10-07
Abstract: L'invention concerne un système pour réaliser une cartographie et une électroporation intégrées comprenant un cathéter à panier constitué d'une pluralité de cannelures et d'une pluralité d'électrodes montées sur chaque cannelure de la pluralité de cannelures. Le système comprend également un dispositif de commande connecté au cathéter à panier. Le dispositif de commande comprend un processeur configuré pour activer au moins un sous-ensemble d'électrodes afin de réaliser une électroporation, l'activation d'au moins le sous-ensemble d'électrodes générant des trajets de courant entre des électrodes sur une cannelure donnée et entre des électrodes sur des cannelures adjacentes.
Patent WO-2022103556-A1 (WO)
Title: Filtre de prévention de rétroréflexion
Inventor: SHEPPARD GILES
IPC: G02B23/12
Filed: 2021-10-20
Abstract: L'invention concerne un système optique fournissant une rétroréflexion réduite comprenant un élément optique avec une ouverture optique. Un filtre de prévention de rétroréflexion a un matériau d'obstruction partielle configuré pour absorber ou réfléchir un sous-ensemble de la bande d'onde du système optique tout en transmettant le reste. Le matériau d'obstruction partielle est agencé pour occuper une première partie de l'ouverture optique qui est au moins la moitié de l'ouverture optique, et le matériau d'obstruction partielle n'occupe pas une seconde partie de l'ouverture optique pour le reste de l'ouverture optique.
Patent WO-2022103563-A1 (WO)
Inventor: HARRIS RALPH E
IPC: F04B11/00
Filed: 2021-10-21
Abstract: A reciprocating pump having a power end and a fluid end includes an auger assembly that is designed to evenly distribute solid particles in the fluid along the suction manifold. The auger assembly includes a helical blade that extends along a substantial length of the suction manifold, and first and second end supports coupled to both ends of the helical blade, the first and second end supports engaging suction manifold cavity walls to maintain proper position of the helical blade within the suction manifold cavity.
Patent WO-2022164488-A1 (WO)
Title: Shielding gas for laser welding of aluminum and aluminum alloys and method and apparatus for use thereof
Inventor: PIERCE KEITH
IPC: B23K35/38
Filed: 2021-10-26
Abstract: A shielding gas, apparatus, and method are provided for laser welding workpieces comprising aluminum or aluminum alloy. The shielding gas includes argon (Ar); and active gas components in a range of 0.5% to 3% by volume of the shielding gas. The active gas components include a combination of oxygen (O2) and at least one of nitrous oxide (N2O) and nitrogen (N2).
Patent WO-2022103790-A1 (WO)
Inventor: PARISH DAVID
IPC: G06F1/16
Filed: 2021-11-10
Abstract: L'invention concerne des poignées améliorées pour des dispositifs portatifs (tels que des téléphones mobiles portatifs). En particulier, les poignées décrites dans la présente invention pallient un grand nombre de problèmes techniques (tels que des problèmes ergonomiques) rencontrés dans des poignées connues pour des dispositifs portatifs. Des modes de réalisation peuvent comprendre une poignée articulée qui comprend un dispositif de retenue de doigt (1), une base de montage de téléphone (3), et une liaison pivot (2) reliant le dispositif de retenue de doigt (1) et la base de montage de téléphone (3).
Patent WO-2022104001-A1 (WO)
Title: Banques de protéines étendues et leurs utilisations
Inventor: LIN CHI-WANG
IPC: C12N15/10
Filed: 2021-11-12
Abstract: L'invention concerne des banques de peptides présentant une diversité de monomères étendue. De telles banques peuvent être construites par division de codons dégénérés d'acides aminés naturels pour permettre l'incorporation d'acides aminés non naturels. De telles banques peuvent être utilisées pour construire et identifier des ligands peptidiques macrocycliques puissants à haute affinité qui peuvent être utiles pour cibler des interfaces protéine-protéine ou des interfaces d'interactions similaires avec une haute affinité et une haute spécificité.
Patent WO-2022150129-A1 (WO)
Title: Systems and methods for controlling laser power in light detection and ranging (lidar) systems
Inventor: YEH YU-CHING
IPC: H01S3/094
Filed: 2021-12-06
Abstract: Embodiments of the disclosure provide a system for controlling laser pulses emitted by an optical sensing device. The system may include a laser emitter configured to emit a plurality of laser pulses, a power source configured to deliver electrical currents to the laser emitter, and a control circuit configured to deliver electrical currents from the power source to the laser emitter. The control circuit may include a first control path configured to deliver a first electrical current rising at a first rate from the power source to the laser emitter to emit a first laser pulse. The control circuit may also include a second control path configured to deliver a second electrical current rising at a second rate from the power source to the laser emitter to emit a second laser pulse following the first laser pulse. The second rate may be higher than the first rate.
Patent WO-2022076979-A1 (WO)
Title: Protéine de fusion utile pour la vaccination contre les rotavirus
Inventor: ANSTROM DAVID
IPC: C07K14/47
Filed: 2021-10-04
Abstract: La présente invention concerne des polypeptides construits par recombinaison utiles pour préparer des vaccins, en particulier pour réduire un ou plusieurs signes cliniques provoqués par une infection à rotavirus. Plus particulièrement, la présente invention concerne une protéine de fusion comprenant dans la direction N- à C-terminal (i) un fragment immunogène d'une protéine VP8 de rotavirus et (ii) un fragment Fc d'immunoglobuline tel que, par exemple, un fragment Fc d'IgG, ladite protéine de fusion pouvant être utilisée dans une méthode pour réduire un ou plusieurs signes cliniques, la mortalité ou l'excrétion fécale provoquée par une infection à rotavirus chez les porcs.
Patent WO-2022115837-A1 (WO)
Inventor: SERVANT GUY
IPC: G01N33/566
Filed: 2021-11-19
Abstract: The present disclosure generally provides methods for identifying compounds that enhance kokumi taste, and related uses. In some particular aspects, the disclosure provides methods of identifying compounds that enhance kokumi taste by determining whether the compounds modulate the T1R1/T1R3 taste receptor. In some other aspects, the disclosure provides uses of such identified compounds to enhance the kokumi taste of an ingestible composition. In some further aspects, the disclosure provides flavored products, such as food or beverage products, that incorporate such ingestible compositions, and which thereby impart or enhance an umami taste in a flavored article. In some other aspects, the disclosure provides ingestible compositions that contain compounds known to impart or enhance umami taste, such as glutamates, aspartates, and purinic ribonucleotides, such as inosine monophosphate (IMP) and guanosine monophosphate (GMP). In some aspects, the inclusion of kokumi-enhancing compounds in flavored products allows one to reduce or eliminate the concentration of glutamate or aspartate in certain food and beverage products.
Patent WO-2022150731-A1 (WO)
Inventor: SHAH JAGESH VIJAYKUMAR
IPC: A61K39/00
Filed: 2022-01-10
Abstract: Provided herein are methods of transducing resting or non-activated T cells using CD8-targeted viral vectors.
Patent WO-2022159404-A1 (WO)
Inventor: LI SIQUAN
IPC: A23K10/30
Filed: 2022-01-18
Abstract: Un produit à base de jaune d'œuf modifié par des enzymes peut être fourni sous forme liquide ou pulvérulente. Il peut être utilisé pour réaliser une mayonnaise avec une viscosité très élevée, même en l'absence d'éventuels additifs épaississants, et présente une bonne stabilité à des températures supérieures à 90 °C (par exemple 200 °F).
Patent WO-2022164831-A1 (WO)
Title: Système, procédé et produit-programme informatique de conversion de protocole
Inventor: KEMPER COREY
IPC: G16H20/17
Filed: 2022-01-26
Abstract: Un système, un procédé et un produit-programme informatique de conversion de protocole peuvent obtenir un protocole fixe comprenant les paramètres de protocole fixe suivants : un débit d'au moins un fluide à administrer à un patient dans au moins une phase d'une injection et un volume du ou des fluides à administrer au patient dans la ou les phases de l'injection ; fournir une série d'invites et recevoir une série de réponses d'utilisateur en réponse à la série d'invites ; et générer, sur la base de la série de réponses d'utilisateur et du protocole fixe, un protocole intelligent comprenant les paramètres de protocole intelligent suivants, selon lesquels le système d'injection est configuré pour commander l'administration du ou des fluides au patient dans l'injection : un facteur de dose et un procédé de dose.
Patent WO-2023014399-A1 (WO)
Inventor: HORI SATORU
IPC: G03G15/08
Filed: 2022-02-04
Abstract: Un exemple d'appareil de formation d'image comprend une bande de transfert intermédiaire pour tourner autour d'un rouleau d'entraînement et d'un rouleau de tension, un dispositif de nettoyage pour récupérer les particules de toner à partir de la bande de transfert intermédiaire, et un boîtier relié au dispositif de nettoyage pour recevoir les particules de toner récupérées à partir de la bande de transfert intermédiaire. Le boîtier comprend une partie pivotante pour tourner autour d'un axe de rotation qui s'étend parallèlement à une direction longitudinale du rouleau de tension.
Patent WO-2022225619-A1 (WO)
Title: Sounding operations for radio-frequency (rf) sensing
Inventor: MERLIN SIMONE
IPC: H04W74/08
Filed: 2022-03-08
Abstract: This disclosure provides methods, devices and systems for radio frequency (RF) sensing in wireless communication systems. In some implementations, a transmitter device transmits sounding sequences configured for channel estimation over a wireless channel to a receiver device. The transmitter device also transmits or receives non-sounding frames associated with a channel report of the receiver device. The transmitter device transmits a frame soliciting the channel report from the receiver device. The transmitter device receives the channel report, which may include channel state information (CSI) of the wireless channel responsive to at least the sounding sequences. Some types of channel reports may take longer to generate than other types of channel reports. Transmitting or receiving the non-sounding frames during the time period may prevent other devices from accessing the wireless channel when the receiver device needs additional time to generate a certain type of channel report.
Patent WO-2022197575-A1 (WO)
Inventor: CHILDERS KALEEN KONRAD
IPC: A61K31/167
Filed: 2022-03-14
Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, R 1 , R 2 , and R 3  are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
Patent WO-2022197758-A1 (WO)
Title: Heteroaryl inhibitors of plasma kallikrein
Inventor: PAPAIOANNOU NIKOLAOS
IPC: A61P9/00
Filed: 2022-03-16
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
Patent WO-2022204093-A1 (WO)
Title: Enzymes de modification de l'adn et fragments actifs et variants associés et méthodes d'utilisation
Inventor: BOWEN TYSON D
IPC: C12N15/10
Filed: 2022-03-22
Abstract: Compositions et procédés comprenant des polypeptides de désaminase pour l'édition ciblée d'acides nucléiques. Les compositions comprennent des polypeptides de désaminase. L'invention concerne également des protéines de fusion comprenant un polypeptide de liaison à l'ADN et une désaminase de l'invention. Les protéines de fusion comprennent des nucléases guidées par ARN fusionnées à des désaminases, éventuellement en complexe avec des ARN guides. Les compositions comprennent également des molécules d'acide nucléique codant pour les désaminases ou les protéines de fusion. L'invention concerne aussi des vecteurs et des cellules hôtes comprenant les molécules d'acide nucléique codant pour les désaminases ou les protéines de fusion.
Patent WO-2022221096-A1 (WO)
Title: Machine-learining driven data analysis based on demographics, risk and need
Inventor: MAGOON AKASH
IPC: G06N20/00
Filed: 2022-04-05
Abstract: A data processing system for recommending insurance plans implements obtaining an electronic copy of demographic information associated with a user; analyzing the demographic information with a first machine learning model to recommend a bundle of insurance policies based on the demographic information, wherein the first machine learning model is configured to group insured people having similar demographics into clusters and to generate the bundle of insurance policies based on predicted medical insurance consumption associated with a respective group into which the model predicts that the first user falls; customizing the recommended bundle of insurance policies based on the demographic information associated with the user to generate a customized bundle of insurance policies; generating an insurance recommendation report that presents the customized bundle of insurance policies to the user; and causing a user interface of a display of a computing device associated with the user to present the insurance recommendation report.
Patent WO-2022235418-A1 (WO)
Title: Oblique illumination for overlay metrology
Inventor: HILL ANDREW V
IPC: G03F7/20
Filed: 2022-04-18
Abstract: An overlay metrology system may include an overlay metrology tool suitable for measurement of an overlay target on a sample, the overlay target including one or more grating structures with patterned features distributed along one or more measurement directions. The overlay metrology tool may include an objective lens and an illumination pathway to illuminate the overlay target with two or more oblique illumination lobes distributed among one or more illumination distributions such that, for each of the measurement directions, diffraction orders of the one or more illumination distributions by the overlay target that are collected by the objective lens exclusively include a 0-order diffraction lobe and a single first-order diffraction lobe from at least one of the two or more illumination lobes. The overlay metrology tool may further include at least one detector to image the sample and a controller to generate overlay measurements based on the images.
Patent WO-2022232241-A1 (WO)
Title: 3d printer system including g-code conversion process and hardware abstraction layer
Inventor: HEGAZY OMAR
IPC: G06F19/00
Filed: 2022-04-27
Abstract: In an example implementation, a system including a computer including a processor and a memory. The memory includes instructions such that the processor is programmed to convert G-code to G-node data, generate a plurality of windows based on G-node segments, calculate an average velocity based on the plurality of windows, where the velocity corresponds to a 3D printer head. The processor is also programmed to determine a temperature corresponding to the average velocity, and insert a G-code heat command into a G-code command file based on the determined temperature. The processor can be further programmed to insert a pre-heat G-code command into the G- code command file.
Patent WO-2022236106-A1 (WO)
Title: Amplification and detection of compound signals
Inventor: HUBBARD ALLEN
IPC: G01N30/86
Filed: 2022-05-06
Abstract: Systems and methods for amplification and detection of metabolite signals are provided. A plurality of files containing m/z signal intensities may be captured by a mass spectrometer. Each file of m/z signal intensities may include signals associated with mass measurements of compounds in a respective sample. The datasets of the chromatograms may be combined into a merged spectra of m/z signal intensities. A concentration of signals may be identified in the merged chromatogram as following a specified statistical distribution and determined to be indicative of a metabolite when the concentration of signals corresponds to one or more mass measurements associated with a metabolite and an isotopologue of the metabolite.
Patent WO-2022240871-A1 (WO)
Inventor: TOWLES MICHAEL
IPC: G06F16/27
Filed: 2022-05-10
Abstract: A system managing software program transactions and use has an Internet platform with a server and a processor coupled to a data repository, executing software providing interactive interfaces to users, stored profiles for registered users of the system, and an inventory of the software programs for sale or rent, each software program defined by a Smart Contract (SC) in a Blockchain. The system is characterized in that a registered user selects a software program, and the system interacts with the registered user to agree to a price and terms of use, the agreed price and terms of use are instantiated by the system in a non- fungible token (NFT) minted by the SC, the NFT is populated with critical properties, the NFT is associated with a profile for the registered user, recorded in a Software Title Ledger, and the software program is provided to the registered user ready to execute.
Patent WO-2022251224-A1 (WO)
Title: Inhibiteurs de wee1 et méthodes de traitement du cancer
Inventor: PINCHMAN JOSEPH
IPC: C07D519/00
Filed: 2022-05-24
Abstract: L'invention concerne des composés de formule générale (I). De tels composés, ainsi que des sels pharmaceutiquement acceptables et des compositions associés sont utiles pour le traitement de maladies ou d'affections, notamment d'affections caractérisées par une prolifération cellulaire excessive, telles que le cancer du sein.
Patent WO-2022256222-A1 (WO)
Inventor: MEHEDI MD AMINUL
IPC: C22C38/00
Filed: 2022-05-26
Abstract: La présente invention divulgue des matériaux magnétiques doux et des techniques associées destinées à la fabrication de tels matériaux magnétiques doux. De tels matériaux magnétiques peuvent être à base de nitrure de fer, d'oxynitrure de fer, de boronitrure de fer et/ou de carbonitrure de fer. Les techniques divulguées par la présente invention pour la fabrication de particules ferromagnétiques peuvent être utilisées pour commander des propriétés magnétiques et électriques fonctionnelles des particules fabriquées. Certaines techniques divulguées par la présente invention peuvent être utilisées pour former un revêtement sur une particule, le revêtement présentant une épaisseur comprise entre 0,05 et 1,00 µm. Ces matériaux magnétiques fabriqués par l'intermédiaire d'une ou de plusieurs des techniques divulguées par la présente invention peuvent présenter à la fois une induction magnétique relativement élevée et une résistivité électrique relativement élevée.
Patent WO-2022265868-A1 (WO)
Title: Interdigitated electrode assemblies, liquid crystal devices, and methods for manufacture
Inventor: BUTLER DOUGLAS LLEWELLYN
IPC: G02F1/1343
Filed: 2022-06-03
Abstract: Disclosed are interdigitated electrode assemblies and liquid crystal devices and windows including such assemblies, wherein the interdigitated electrode assembly comprises: a substrate; a plurality of first electrodes and a plurality of second electrodes, wherein the plurality of first electrodes and the plurality of second electrodes are interdigitated; at least one first insulator which overlays at least a portion of the plurality of second electrodes; and a first bus bar which overlays the at least one first insulator and does not electrically contact the plurality of second electrodes. Also disclosed are methods for manufacturing interdigitated electrode assemblies and liquid crystal devices and windows including those assemblies.
Patent WO-2022261005-A1 (WO)
Title: Treatment of angptl4 related diseases
Inventor: GOTTESMAN OMRI
IPC: C12N15/113
Filed: 2022-06-06
Abstract: Provided are compositions comprising an oligonucleotide that targets Angiopoietin-like 4 (ANGPTL4). The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Oligonucleotide modification patterns are included that may be used to improve their stability or efficacy. Also provided herein are methods of treating a cardiometabolic disorder by providing an oligonucleotide that targets ANGPTL4 to a subject in need thereof. Some embodiments include treating a subject with hepatic steatosis or another cardiometabolic disorder.
Patent WO-2022266256-A1 (WO)
Inventor: WOLF FABIAN
IPC: G16B40/20
Filed: 2022-06-15
Abstract: Systems and methods for associating cellular constituents with a cellular process of interest are provided. Constituent vectors comprising abundances for a first plurality of cells representing annotated cell states are formed and used to obtain a latent representation of constituent modules having subsets of constituents. A constituent count data structure comprising abundances of the constituents for a second plurality of cells representing covariates of interest is obtained. An activation data structure is formed by combining the latent representation and the constituent count data structure, using constituents as a common dimension. A model is trained using a difference between the predicted and actual absence or presence of each covariate in each cellular constituent module represented in the activation data structure, thus adjusting covariate weights indicating a correlation between covariates and constituent modules across the activation data structure. The covariate weights are used to identify constituent modules associated with covariates of interest.