baber/WOPTO huggingface dataset:
Patent CA-2461351-A1 (CA)
Inventor: KREITMAN ROBERT J
IPC: A61K47/48
Filed: 2002-09-25
Abstract: Les immunotoxines recombinées sont des protéines de fusion constituées des domaines Fv d'anticorps fusionnés à des toxines bactériennes ou végétales. RFB4 (Fv)-PE38 est une immunotoxine ayant pour cible les CD22 exprimées sur les cellules B et les tumeurs malignes se développant à partir des cellules B. La présente invention concerne des anticorps et des fragments d'anticorps présentant une aptitude améliorée à la liaison à l'antigène CD22 des cellules B et des tumeurs malignes se développant à partir des cellules B, par rapport au RFB4. Les immunotoxines préparées à partir des anticorps ou des fragments d'anticorps de l'invention présentent une cytotoxicité améliorée contre les cellules cancéreuses exprimant des CD22. Par ailleurs, l'invention concerne des compositions qui incorporent ces anticorps à des molécules d'immunotoxines chimères pouvant être utilisées dans des médicaments, ainsi que des méthodes pour inhiber la croissance et la prolifération des cellules leucémiques et lymphoïdes.
Patent CA-2461423-A1 (CA)
Inventor: RICE DAVID K II
IPC: C09J7/40
Filed: 1995-01-20
Abstract: The present invention is directed to a printable release composition used for pressure sensitive labels and the like. The invention is also directed to an article, such as a label, that comprises a substrate such as paper, optionally a thermal transfer primer coating coated onto the substrate and a release layer coated onto the transfer primer coating or onto the substrate. The printable release composition of the present invention may be used with labels having permanent, repositionable or removable adhesives. The particular composition of the release layer depends on the type of adhesive that is appropriate for the desired end use.
Patent CA-2463362-A1 (CA)
Title: Device for delivering medicines by transpalpebral electrophoresis
Inventor: ROY PIERRE
IPC: A61M37/00
Filed: 2002-10-11
Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.
Patent CA-2463828-A1 (CA)
Inventor: ANEJA ARUN PAL
IPC: D04H1/70
Filed: 2002-12-10
Abstract: This invention provides corrugated fiberfill structures with improved properties and processes for making the same. This invention further provide s articles made from the improved corrugated fiberfill structures of the prese nt invention.
Patent CA-2469471-A1 (CA)
Title: Reseaux de donnees electriques
Inventor: CHATTER MUKESH
IPC: H04B10/291
Filed: 2002-07-08
Abstract: L'invention concerne un procédé et une architecture de fonctionnement améliorée permettant de mélanger des réseaux photoniques et des réseaux à commutation par paquets et de les unir ou de les intégrer dans un seul dispositif, avec un plan de commande de logiciel. Cette caractéristique permet d'optimiser le rendement des réseaux mixtes et plus particulièrement le rendement des circuits optiques.
Patent CA-2470725-A1 (CA)
Title: Digital ink annotation process and system for recognizing, anchoring and reflowing digital ink annotations
Inventor: SHILMAN MICHAEL
IPC: G06F40/00
Filed: 2004-06-10
Abstract: A digital ink annotation process and system for processing digital documents and digital ink annotations therein. The process and system maintain an annotation's position within a document such that the original intent and meaning of the annotation is preserved. This is true even if the document is edited, resized, displayed on a different device or otherwise modified. The digital ink annotation process includes automatic and manual grouping of digital ink strokes within a document to define digital ink annotations, classifying the annotations according to annotation type, and anchoring the annotations to appropriate regions or positions in a document. The process further includes reflowing the annotations in a new document layout such that the annotations conform and adapt to the new layout while preserving the original intents and meanings of the annotations. A digital ink annotation system includes a classification module, an anchoring module, a reflow module and a clean-up module to implement the digital ink annotation process.
Patent CA-2472176-A1 (CA)
Inventor: DREYER VOLKER
IPC: G01D11/24
Filed: 1999-09-01
Abstract: A sensor which includes a sensor section and an electronics section. The sensor section includes a sensor element. The electronics section includes a insert containing electronics. A passageway extends between the sensor section and the electronics section, through which the electronics section is connected to the sensor section. A connection element for the electrical connection of the sensor element of the sensor section to the electronics of the electronics section, which is an integral part of the insert, extends into and seals the passageway. With a sensor in accordance with the present invention, the sensor element is permanently protected against moisture.
Patent CA-2472886-A1 (CA)
Inventor: RAAB MICHAEL R
IPC: C12N15/82
Filed: 2003-01-07
Abstract: Transgenic plants that express CIVPS or intein modified proteins, compositions of matter comprising them, products of diverse applications made from the transgenic plants, methods to construct the transgenic plants containing CIVPS  or intein modified genes, methods to express CIVPS or intein modified proteins in plants, and methods of using the transgenic plants.
Patent CA-2475446-A1 (CA)
Title: Viral variants with altered susceptibility to nucleoside analogs and uses thereof
Inventor: BARTHOLOMEUSZ ANGELINE INGRID
IPC: A61K39/29
Filed: 2003-02-05
Abstract: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
Patent CA-2475988-A1 (CA)
Inventor: SCHMID DIETRICH
IPC: B01D50/00
Filed: 2003-02-11
Abstract: The invention relates to a filter system for extracting particles and/or dro ps of liquid from the air flowing through the filter device. Said filter system consists of a filter layer arranged in a plane and a cyclone collector which is arranged in the edge region of the filter layer. Said cyclone collector i s provided with means which, compared with the filter layer, create a higher flow speed and stronger vortexing of the circulating air. The cyclone collector can be produced from horizontal cyclone elements, curved, horizont al elements or from expanded metal.
Patent CA-2477295-A1 (CA)
Title: Trans-splicing mediated imaging of gene expression
Inventor: MITCHELL LLOYD G
IPC: C12N5/06
Filed: 2003-02-25
Abstract: The present invention provides methods and compositions for imaging of gene expression in cells. The compositions of the invention include pre- trans~splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate a trans~splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA) capable of encoding a reporter molecule. The PTMs of the invention are designed to interact with target pre-mRNAs thereby providing a method for detection of target pre-mRNA expression. The methods and compositions of the invention may be utilized to monitor the expression of specific genes within a cell. In instances where specific gene expression is associated with a disease, the present invention provides diagnostic methods and compositions. Such diseases include infectious diseases, proliferative disorders such as cancer, genetic, neurological and metabolic disorders, to name a few. Additionally, the present invention may be used in screening assays to identify compounds capable of modulating gene expression or in assays designed to identify protein/protein interactions. The invention is demonstrated by way of example in which papilloma virus gene expression within a cell was detected using a bioluminescence assay system.
Patent CA-2477796-A1 (CA)
Inventor: RACHED MOISES CISNEROS
IPC: C08K5/00
Filed: 2003-02-11
Abstract: A process is provided for crosslinking polymer modified asphalt compositions using a combination of a crosslink initiator, co-agent and crosslinkable polymer, to provide a process that is more reliable and more reproducible and that gives products that have a combination of properties that are superior to conventional sulfur crosslinked compositions.
Patent CA-2480037-A1 (CA)
Title: Removing agent for heavy metal in water
Inventor: MOURI MOTOYA
IPC: C02F1/28
Filed: 2003-03-19
Abstract: A remover for heavy metals contained in water, comprising both a synthetic zeolite which is replaced with magnesium ions in an amount of at least 10 mole % of the whole cation-exchange capacity and with magnesium and calcium ions in a total amount of at least 60 mole % thereof and activated carbon at a weight ratio of 2 : 98 to 50 : 50. This remover can remove heavy metal ions contained in water (particularly tap water) through adsorption to high extent and also remove residual chlorine and trihalomethane efficiently without losing the balance between calcium ion and magnesium ion, thus giving good and healthful water.
Patent CA-2481337-A1 (CA)
Inventor: BARNES CHRISTOPHER C E
IPC: B32B7/035
Filed: 2004-09-13
Abstract: A multi-layer lamination is formed from a core sandwiched between a first oriented plastic layer and a second oriented plastic layer. The orientations of the plastic layers cross at an angle between but not equal to zero degrees and 180 degrees relative to one another. A method for making the lamination is also disclosed.
Patent CA-2483279-A1 (CA)
Inventor: COPETE VIDAL TERESE
IPC: D06M23/12
Filed: 2003-04-22
Abstract: Fibers and textiles are finished with a composition comprising mixtures of a) microencapsulated active components selected from the group consisting of squalane, chitosan, retinol, caffeine, vegetable proteins and hydrolysis products thereof, carotenes and jojoba oils and (b) binders.   The finish provides fibers and textiles having improved wearing comfort.
Patent CA-2483346-A1 (CA)
Title: Sand and particle separator for fluid pumping systems
Inventor: KAMPFEN THEODORE A
IPC: B04C9/00
Filed: 2003-04-22
Abstract: A sand and particle (20) separator for fluids is configured to optimize the particulate removal and minimize the diameter of the system. An auger (32) is located at the lower end of the separation chamber (24) and is driven by a drive shaft (40). The drive shaft may extend through the separation chamber (24) and to drive a pump (26) located above the separation chamber. Shaped orifices (44) may be present to create centrifugal forces. To increase the speed of the fluid within the separator, a conical entrance (46) may be used to create a venturi effect on the fluid entering the separation chamber (24).  A reflector (48) may be attached to reflect the cleaned fluid upward toward the pump (26).
Patent CA-2484250-A1 (CA)
Title: Sulfonated polymer having nitrile-containing hydrophobic block and solid polymer electrolyte
Inventor: HIGAMI MAKOTO
IPC: C08G65/48
Filed: 2004-10-06
Abstract: Provided are a sulfonated polymer capable of high hot water resistance even if it has an increased amount of the sulfonic groups introduced therein, and a solid polymer electrolyte containing the sulfonated polymer that has high proton conductivity and excellent generating performance. The sulfonated polymer has repeating units represented by the formula (1'): (see formula I) wherein B's are each independently an oxygen or a sulfur atom, R1 to R3 may be the same or different and are selected from a hydrogen atom, a fluorine atom, a nitrite group and an alkyl group, n is an integer of 2 or greater, and Q is a structure represented by the formula (q) : (see formula I) wherein A is independently a divalent atom or organic group or a direct bond, and R4 to R11 may be the same or different and are selected from a hydrogen atom, a fluorine atom, an alkyl group and an aromatic group.
Patent CA-2484737-A1 (CA)
Inventor: AZEVEDO MAX
IPC: C08F222/32
Filed: 2003-02-19
Abstract: La présente invention concerne un procédé d'adhésif utilisant une composition d'adhésif comprenant un adhésif cyanoacrylate et un agent stabilisant destinée à coller ensemble des parties d'un substrat, qui convient en particulier pour des sutures et pour des opérations médicales similaires. Cette invention se fonde sur la découverte qu'on obtient des améliorations remarquables en ajoutant une étape de suppression d'agent stabilisant des compositions d'adhésif dans le processus de fabrication avec les étapes préalables connues qui consistent: (a) à prendre une composition d'adhésif comprenant un adhésif cyanoacrylate et un agent stabilisant, (b) à présenter un substrat destiné à recevoir au moins une partie de cet adhésif cyanoacrylate et (c), à appliquer cette partie au substrat. Cette invention concerne aussi des dispositifs utilisés lors de la mise en oeuvre de ce procédé.
Patent CA-2485825-A1 (CA)
Inventor: DORR PATRICK KARL
IPC: A61P43/00
Filed: 2003-05-14
Abstract: The present invention relates to the use of an assay that measures receptor residence time of a ligand on its receptor in vitro for the identification of a ligand for that receptor predicted to be efficacious in vivo in the treatment of a disease that responds to modulation of that receptor's natural function.
Patent CA-2486669-A1 (CA)
Title: A method for making a supporting body for the lock of a motor vehicle, and a supporting body thus obtained
Inventor: MICHETTI CLAUDIO
IPC: B60R25/04
Filed: 2004-10-27
Abstract: Described herein is a method for making a supporting body (1) for the lock of a motor vehicle, comprising the steps of: forming an intermediate element (8) made of electrically insulating material provided with conductive paths (3); setting said intermediate element (8) inside a mould (23) for forming the supporting body (1); and injecting electrically insulating material in the mould (23) for carrying out co-moulding of the supporting body (1). The intermediate element (8) and the conductive paths (3) are made independently, and the conductive paths (3) are fixed on opposite faces (9, 10) of the intermediate element (8) by constraint means (15, 16) of a mechanical type.
Patent CA-2487624-A1 (CA)
Inventor: LIVEY GORDON C
IPC: B65D27/06
Filed: 2004-11-16
Abstract: An envelope is disclosed which includes a front panel and a rear panel. Each of the front and rear panels are made from an outer layer and an inner cushioning layer formed from a plastic air-cellular material. The front panel is connected to the rear panel along a bottom edge and a pair of side edges. A folding flap is connected to a top edge of the rear panel. The flap includes a number of separable portions. Each of the separable portions has an adhesive layer on an adjacent surface thereof. The flap is movable between a closed position where a selected separable portion is adhered to the front panel, and an open position where the flap is separated from the selected separable portion. The flap may be repeatedly closed and opened by sequentially adhering and separating the separable portions in a proximal direction.
Patent CA-2488464-A1 (CA)
Title: Rotary and reciprocal well pump system
Inventor: BROWN DONN J
IPC: E21B43/12
Filed: 2004-11-25
Abstract: A well pumping system has a downhole rotary pump that drives a downhole reciprocating pump. The reciprocating pump is an intensifier, having a primary piston and a secondary piston of lesser diameter. A sequencing valve connects between the discharge of the rotary pump and the primary cylinder for alternately supplying well fluid from the rotary pump to the primary piston to stroke the primary and secondary pistons. The secondary piston pumps well fluid to the surface.
Patent CA-2491038-A1 (CA)
Inventor: FIEBIG HELMUT
IPC: C12P21/00
Filed: 2003-06-11
Abstract: The invention relates to the provision of the gene sequence of the grass pollen main allergen Phl p 4. The invention also includes fragments, novel combinations of partial sequences and point mutants having a hypoallergenic effect. The recombinant DNA molecules and the derived polypeptides, fragments, novel combinations of partial sequences and variants can be used for the therapy of pollen-allergy diseases. The recombinantly produced proteins can be used for <i>in vitro</i> and <i>in vivo</i> diagnosis of pollen allergies.
Patent CA-2496206-A1 (CA)
Inventor: EVANGELIDES STEPHEN G JR
IPC: H04B10/08
Filed: 2003-08-20
Abstract: A method is provided for using OTDR with a bi-directional optical transmission system that includes first and second terminals (310, 320) interconnected by at least first and second unidirectional optical transmission paths (306, 308) having at least one repeater (314) therein. The method begins by transmitting optical probe signals over the first optical path and receiving over the second optical path returned OTDR signals in which status information concerning the first optical is embodied. The optical probe signals and the returned OTDR signals are transmitted and received, respectively, at time intervals allowing individual spans of this optical path, which are separated by the repeater or repeaters, to be monitored in a sequential manner.
Patent CA-2496321-A1 (CA)
Inventor: YALKINOGLU OEZKAN
IPC: C12Q1/37
Filed: 2003-08-11
Abstract: A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS).  The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.
Patent CA-2497180-A1 (CA)
Title: Treatment of metastatic breast cancer with anthracyclines, taxanes and an histamine antagonist
Inventor: BRANDES LORNE J
IPC: A61K31/38
Filed: 2003-09-03
Abstract: An improved adjuvant treatment of metastatic breast cancer in which patients are administered an anthracycline chemotherapeutic agent and a taxane chemotherapeutic agent is provided in which a diphenyl compound which is a potent antagonist of histamine binding at the intracellular histamine recept or is initially administered prior to administration of the chemotherapeutic agents.
Patent CA-2498373-A1 (CA)
Title: System and method for providing consumer rewards
Inventor: CRUZ MARIO A
IPC: G06Q30/02
Filed: 2005-02-25
Abstract: An automated consumer rewards/incentive program that accepts a registration of a consumer. The registration entitles the consumer to receive the benefits of the incentive program. To track the fulfillment of reward earning criteria established by member businesses, the registration includes information indicative of a credit card of the consumer. The system may track member consumer credit card transactions without receiving personal information for non-members by using a one way hash function. The system uses the credit card information to determine when member customers perform a transaction at a member business.  When a member customer performs a transaction at a member business using the registered credit card, the system and method examines the credit card transactional information to determine if the consumer fulfilled the requirements of the incentive program for the member business. If the transactional information indicates that the consumer fulfilled the criteria of the rewards program of the member business, the consumer is rewarded in accordance with the benefits of the incentive program.
Patent CA-2498804-A1 (CA)
Title: Volumetric karl-fischer titration with stabilized solvent
Inventor: DESOTELLE GENE
IPC: G01N33/18
Filed: 2005-03-01
Abstract: Described are methods for avoiding false low water determinations in a volumetric Karl-Fischer water determination by including an amine group-containing compound as a stabilizer in the solvent charged to the reaction vessel separate from the titration. Also, described are solvent/stabilizer compositions for such methods.
Patent CA-2499321-A1 (CA)
Title: Obtaining and use of therapeutic antibodies entering into the cell
Inventor: KOGERMAN PRIIT
IPC: A61K47/48
Filed: 2003-09-16
Abstract: The invention relates to the development of a novel technology of (cancer- )specific antibodies entering into the cell and their use for treatment of human diseases (primarily cancer). Such antibody (drug) would act by directl y modulating the cancer-generating signals. The expected effects and principle s of action of such antibodies are inactivation of intracellular proteins and thus they could be used for the treatment of diseases, where the activity of intracellular proteins must be modulated for effective treatment (primarily malignant tumors, but also many other diseases, which can be treated by inactivation of intracellular proteins). Above-mentioned antibody technology would also be applied elsewhere (e.g. scientific laboratories, that are engaged in investigation of intracellular proteins etc).
Patent CA-2499770-A1 (CA)
Title: Riboswitches, methods for their use, and compositions for use with riboswitches.
Inventor: WICKISER JOHN K
IPC: C12N15/67
Filed: 2003-09-22
Abstract: It has been discovered that certain natural mRNAs serve as metabolite- sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural "riboswitches" (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non~immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesi s. Newly constructed genetic regulation networks can be applied in such areas a s living biosensors, metabolic engineering of organisms,and in advanced forms of gene therapy treatments.