baber/WOPTO huggingface dataset:
Patent PT-786459-E (PT)
Inventor: BUIZER NICOLAAS
IPC: C07D327/06
Filed: 1997-01-23
Abstract: The invention relates to a method for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula <CHEM>  wherein     X is O, S, NH or N-(C1-C4)alkyl; Y1 and Y2 are each independently hydrogen or substituents selected from halogen, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, formyl, nitro and cyano;   the C*-atom has either the R or the S configuration;  is prepared from a compound of the general formula <CHEM> wherein R1 is hydrogen or a suitable protective group and R2 is hydrogen or wherein R1 and R2 together form an optionally mono- or di-(C1-C3)alkyl substituted methylene bridge;  by the following successive reaction steps:     (i) reaction with a compound of the general formula <CHEM> wherein Z is a hydroxy group or a suitable leaving group, R3 is a hydroxy-protective group and R4 is a halogen atom; or wherein R3 and R4 together constitute a valence bond or a biradical of the formula -C(R11)2-O-, wherein R11 is a straight or branched (C1-C4)alkyl group and wherein the C*-atom has either the R or the S configuration; (ii) subjection of the compound formed to a deprotection/ring-closure reaction; (iii) optionally deprotection of the hydroxy group of the ring-closed product. The invention further relates to enantiomerically pure intermediates, the preparation of these intermediates and the preparation of a starting compound.
Patent PT-876398-E (PT)
Inventor: SETTE ALESSANDRO
IPC: A61K39/002
Filed: 1997-01-23
Abstract: The present invention provides compositions and methods of inducing immune response in patients. In particular, it provides compositions useful in inducing humoral responses against desired immunogens, particularly polysaccharides.
Patent PT-886482-E (PT)
Inventor: KESSLER KURT
IPC: A46B7/06
Filed: 1997-03-04
Abstract: The invention concerns a toothbrush with a bristle head or accessory unit which compensates for the brushing pressure and associated bending of the holder unit as well as hand movements. The toothbrush is characterized in that an O-ring or elastic shoe that is made either detached from or connected to the adjacent components is provided between the replaceable or fixed bristle unit and the holder unit. The bristle unit and holder unit are joined via a ball joint.
Patent PT-946339-E (PT)
Inventor: UNTERNAHRER ROLAND
IPC: F26B23/02
Filed: 1997-11-06
Abstract: The high-temperature treatment apparatus consists of a treatment chamber and at least one combustion chamber (30) with one or more burners (31) operating inn a reduced atmosphere, and fans (26) to circulate the gases between the combustion and treatment chambers. <??>The apparatus has at least gas intake channel (22) from the treatment chamber, connected to the suction side of each fan, and a return channel (23) feeding the gases back to the treatment chamber. The material treated in the apparatus is pre-heated and dried at a temperature close to that at which water vaporises, is heated in a reduced atmosphere and then cooled by injecting water vapour.
Patent PT-907454-E (PT)
Inventor: NUGTEREN MARINUS WILLEM
IPC: B23K11/31
Filed: 1997-05-05
Abstract: The invention relates to a pneumatic operating cylinder for operating a tool in linear movement, wherein the operating cylinder comprises: a working cylinder which is divided by at least one piston arranged therein into a least a first and a second cylinder space, wherein the piston is connected to a piston rod onto which the tool is fixed; and control means for controlling the movement of the piston, wherein the control means are connected to a compressed air feed channel and to an air discharge channel, wherein the control means are adapted to connect the compressed air feed channel in a first position to the first cylinder space and to connect the second cylinder space to the air discharge channel via a choke valve, wherein the control means comprise an auxiliary valve which connects the second cylinder space to the discharge channel when the pressure in the second cylinder chamber is less than a predetermined factor times the pressure in the first cylinder chamber; and wherein the control means are adapted to connect the first cylinder space in a second position to the air discharge channel and to connect the second cylinder space to the compressed air feed channel.
Patent PT-941384-E (PT)
Inventor: ZETTER CLAES
IPC: D21H17/29
Filed: 1997-12-01
Abstract: A "one-shot" composition for use in paper sizing comprises an admixture of a rosin emulsion, a soluble aluminium salt and a cationic starch derivative which has a charged state of 1.0 to 3.5 m equivalents per gramme and which is produced by a process in which the starch structure was split prior to the cationising step.
Patent PT-875248-E (PT)
Inventor: NAPOLI GUIDO DI
IPC: A61K31/728
Filed: 1998-04-28
Abstract: Described herein is the use of hyaluronic acid or of one of its pharmaceutically acceptable salts for the preparation of a formulation for intra-articular irrigation, in the form of an aqueous solution, comprising hyaluronic acid having molecular weight of between 0.5 and 5.0 million daltons or one of its pharmaceutically acceptable salts, in a concentration of between approximately 0.1% and approximately 0.9% weight/volume, and preferably one or more cationic species chosen from among sodium, potassium, calcium and magnesium, and one or more anionic species chosen from among chloride ions, phosphate ions and citrate ions.
Patent PT-919757-E (PT)
Inventor: ANDREAS BOGEL DR
IPC: B32B27/32
Filed: 1998-11-17
Abstract: A tube with a plastic jacket made of a polyethylene (PE)-based mixture contains: (a) 15-45 wt.% chalk as filler; (b) 8-30 wt.% elastomer-modified polyolefin as plasticiser; (c) 1-10 wt.% metal-free thermal stabiliser, and (d) PE homopolymers and copolymers with a content of at least 15 wt.%. The casing composition contains 25-35 wt.% (a), 10-18 wt.% (b) (especially elastomer-modified polypropylene, PE or polybutene), 1-3 wt.% (c), 0.5-3 wt.% pigment mixture for colouring, 0.2-1.5 wt.% lubricants and processing aids, and PE homo- and co-polymer mixture as above, preferably HDPE, LDPE and/or LLDPE. The jacket shows a thermal conductivity of 0.1-0.5 (preferably 0.16-0.35) W/m/K at 40[deg]C, a heat distortion temperature of at least 105[deg]C and an elongation at break (DIN 53455) of at least 680%; it also meets the fire resistance requirements for building materials Class B2 (DIN 4102). The plastic jacket is preferably fitted round a copper pipe.
Patent PT-1008543-E (PT)
Inventor: RHODES DAVID EARL
IPC: B65H19/18
Filed: 1999-11-29
Abstract: An apparatus and method for forming a splice between the trailing end of an expiring web of paper or other material, and the leading end of a new web of material. The apparatus includes a clamp for engaging and stopping the advancing web, and a web severing mechanism to transversely move across and sever the stopped web. A new web holding assembly supports the leading end portion of the new web, and the holding assembly may be lowered to align the trailing and leading ends so that they may be joined by a tape or the like. The web severing mechanism includes a clamping wheel positioned to smooth the trailing end portion of the stopped web before it is severed by a following cutting wheel. Also, a hand-held tool is provided for accurately and safely positioning the leading end portion of the new web on the new web holding assembly.
Patent SG-48593-G (SG)
Title: Process for resorbing liquid-leaks
IPC: C09K3/32
Filed: 1993-04-16
Abstract: Process for resorbing accidental leakages of aqueous or nonaqueous liquids exhibiting toxicity or radioactivity properties. This process consists in spreading on the surface of the liquid granules of at least one porous inorganic compound having a diameter of 1 to 10 mm, allowing the liquid to absorb and spraying onto the granules a composition based on a resin capable of being cured by chemical action with a view to forming a rigid to semirigid mass. Application in the chemical industry and nuclear industry sectors.
Patent IE-34946-L (IE)
Title: Ureidobenzyl alcohol derivatives
IPC: A61K31/17
Filed: 1971-02-11
Abstract: 1286225 Benzyl alcohol derivatives SMITH KLINE & FRENCH LABORATORIES 19 April 1971 [17 Feb 1970] 22115/71 Heading C2C The invention comprises novel benzyl alcohol derivatives, pharmaceutically acceptable acid addition salts thereof, and the corresponding novel aminobenzyloxyphenones of the formulµ wherein R is H, C 1-5 alkIl, phenyl, dimethylaminoethyl, or dimethylaminopropyl; R 1 is C 3-5 alkyl C 3-6 cycloalkyl, C 3-6 cycloalkylmethyl or a radical of the formula R 2 is H, CH3 or CH 2 CH 3 ; R 3 and R 4 each are H, OH or OCH3 and R 5 is H or CH 3 , the compounds of the above formulµ are prepared by reacting the appropriate 4-benzyloxy-α-bromophenones with the corresponding N-benzylamines of the formula followed by, if desired, catalytic hydrogenation. 4 - Benzyloxy - α - bromo - 3 - ureidoawtophenone is obtained by brominating 4-benzyloxy-3- ureido-ecetophenone resulting from the action of ammonia on 4-benzyloxy-3-isocyantoacetophenone which is prepared by reacting 3-amino-4-benzyloxyacetophenone with phosgene. 4 - Benzyloxy - - bromo - 3 - (N<SP>1</SP> - methylureido)-acetophenone is made by brominating 4- benzyloxy 3-(N<SP>1</SP>-methylureido)-acetophenone obtained by treating the above named isocyanate with methylamine. By similar processes 4- benzyloxy - 3 - (N<SP>1</SP> - phenylureido) - acetophenone, 4 - benzyloxy - α - bromo - 3 - (N<SP>1</SP> - phenylureido)- acetophenone, 4 -beizyloxy - 3 -isocyantobutyro - phenone, 4 -benzyloxy- 3 -ureidobutyrophenone, 4- benzyloxy-3-(N,N<SP>1</SP>-dimethylureido)-acetophenone, 4 - benzyloxy - α - bromo - 3 - (N,N<SP>1</SP> - dimethylureido)-acetophenone, and 4 -bemyloxy-α-bromo-3- 3-ureidoobutyrophenone are prepared. 4 - Benzyloxy- α - bromo - 3 - (N- methylureido)-acetophenone is made by brominating 4- benzyloxy- 3- (N-methylureido ) -acetoph enone resulting from the action of sodium cyanate on 4-benzyloxy- 3 -methylaminoccetophenane, which is prepared by hydrolysing 4-benzyloxy-3-(N-methylformamido)-acetophenone, obtained by methylating 4-benzyloxy- 3 -formamidoacetophenone resulting from reaction between ethyl formate and 3-amino-4-benzyloxyacetophenone. Pharmaceutical compositions, having #- adrenergic stimulating activity and suitable for oral or parenteral administration, contain the above novel benzyl alcohol derivative together with suitable pharmaceutical carriers.
[GB1286225A]
Patent IE-32649-L (IE)
Title: Antibiotics
IPC: A23K20/195
Filed: 1969-02-20
Abstract: 1,245,363. Compositions comprising antibiotics. ELI LILLY & CO. 21 Feb., 1969 [23 Feb., 1968; 6 Dec., 1968], No. 9575/69. Headings A5B and A5E. [Also in Division C2] Antibiotics A204I, A204II, mixtures thereof and their alkali metal, alkaline earth metal and basic nitrogen salts (see Division C2) have industrial, pharmaceutical, human and veterinary applications, for example they are active against coccidiosis in chickens, and may be mixed in their feed; and against microbial organisms and may be incorporated into disinfectant solutions for sterilizing around swimming pools and farm buildings. The compounds also exhibit activity against bean powdery, mildew and maize dwarf virus and may be combined with suitable carriers.
[GB1245363A]
Patent IE-44941-L (IE)
Title: Indolizine derivatives
IPC: A61P9/08
Filed: 1977-02-18
Abstract: Novel indolizine derivatives of the general formula: <IMAGE> and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R1 and R2, which are different, represent a hydrogen atom or a group of the formula: <IMAGE> wherein R3 and R4+L, which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive.
[US4103012A]
Patent IE-43734-L (IE)
Title: Transition indicator for two-level signal
IPC: H03K3/013
Filed: 1976-03-02
Abstract: 1534053 Rejecting spurious pulses UNITED TECHNOLOGIES CORP 1 March 1976 [3 March 1975] 08092/76 Heading H3T Changes lasting more than a preset time from either level of a two level logic signal to the other are detected by sensing the occurrence of a transition in said signal, actuating timing means having a preset timing period upon the occurrence of a transition from a first level to a second level, resetting the timing means if the logic signal returns to the first level before the end of the preset period and producing a first output signal at the end of the period if the timing means is not reset. Once the first output signal has been produced, a transition to the first level reactuates the timing means, which is reset if a transition to the second level occurs before the end of the preset period and a second output signal is produced upon expiration of the period if the timing means is not reset. Two embodiments using TTL circuits are described. In one embodiment, Fig. 3 (not shown) three flipflops are used with a synchronous counter as timing means in a circuit which gives a short pulse out on one of two lines each time the input makes a valid high or low transition. In the other embodiment, Fig. 4 (not shown) a monostable circuit is used as timing means together with two flip-flops in a circuit which gives a continuous high or low signal according as the input is high or low.
[GB1534053A]
Patent IE-40739-L (IE)
Title: Phenolic diester derivatives
IPC: C08L23/00
Filed: 1975-03-05
Abstract: 1453916 Phenolic antioxidants SOC FRANCAISE D'ORGANO SYNTHESE 3 March 1975 [12 March 1974] 8719/75 Heading C3P [Also in Division C2] Polymers are stabilized against oxidation by incorporating therein from 0 01 to 0 5% by weight of a compound of the formula wherein Q represents a group of the formula (wherein R 5 , R 6 , R 7 and R 8 , which may be the same or different, are each hydrogen or alkyl) and R is a group derived from a di- or tri-basic, organic or inorganic acid or a group of the formula where n is an integer. Synergistic mixtures with dilauryl thiodipropionate may be used.
[GB1453916A]
Patent IE-820914-L (IE)
Title: Controlling ureaplasma infections
IPC: C07H17/08
Filed: 1982-04-19
Abstract: Method of controlling Ureaplasma infections which comprises administering to an infected or susceptible warm-blooded animal an effective amount of 5-0-mycaminosyl tylonolide or a pharmaceutically acceptable acid addition salt thereof.
[US4341770A]
Patent FI-813157-L (FI)
Inventor: LIAO JOHN CHUAN
IPC: G01N1/30
Filed: 1981-10-12
Abstract: The present invention is a stabilized Romanowsky type stain solution. The stain solution which comprises azures, Methylene Blue and an eosin dye in methanol is stabilized by the addition thereto of an ammonium halide, a primary, secondary or tertiary alkylamine hydrohalide or a combination thereof.
Patent IE-861351-L (IE)
Title: Titanium compounds
IPC: C07F17/00
Filed: 1986-05-21
Abstract: 1. Titanocene complexes having the general formula I   see diagramm : EP0202673,P17,F1   wherein A represents the group   see diagramm : EP0202673,P17,F2   in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.
Patent IE-841371-L (IE)
Title: Carrier matrix analytical test device
IPC: C12Q1/54
Filed: 1984-05-31
Abstract: A test device for determining the presence of a substance in a test sample is disclosed, as well as methods for making and using it. The device comprises a support member having a reagent layer affixed to it which contains a reagent system which produces a detectable response in the presence of the analyte. The reagent layer has an upper layer affixed to the side opposite the support member. The upper layer comprises a polymer which is at least partially crosslinked. The method of use comprises contacting the device with the test sample, wiping the upper layer free of test sample residue, and observing a detectable response.
Patent IE-781481-L (IE)
Title: Optical coupling device
IPC: G02B6/42
Filed: 1978-07-24
Abstract: Mode coupling using grating of ridges and furrows to curve the fibre along a zig-zag path are associated with an index matcher which surrounds the fibre. The average axis of the zig-zag fibre coincides that of the matcher. Light travels along lines all at the same angle to the axis of the matcher and pass through via a conical optical end surface thereof. The optical surface converts the said rays into a parallel beam for coupling with large aperture optical means such as a photo-cell or a LED.
[US4253727A]
Patent IE-831569-L (IE)
Title: Sweetening composition
IPC: A23L27/29
Filed: 1983-07-05
Abstract: A composition and method for heat stabilizing dipeptide sweeteners for baking and cooking is described using a polyglucose or a polymaltose.
Patent IE-851629-L (IE)
Title: Electrical drive systems
IPC: H02P6/06
Filed: 1985-06-28
Abstract: A direct current brushless electric motor has a rotor, and a stator with inwardly extending teeth, between each pair of which a winding slot is defined. The radially inward face of each tooth has a dummy slot shaped so the reluctance forces between rotor and stator due to the presence of the dummy slots are the same as those due to the winding slots. Motor control means incorporate a current feedback loop based on the incoming phase of each phase combination in the phase energization sequence in a driving mode and phase changeover may be initiated by Hall devices, two for each transition point, underlying the axial ends of the rotor magnets. The control means may incorporate a pulse width modulation power supply permitting the establishment of bias currents under motor standstill conditions.
[US4782272A]
Patent IE-43288-L (IE)
Title: Process for the continuous manufacture of nuclear¹chlorinated toluenes.
IPC: C07C17/00
Filed: 1976-08-13
Abstract: o- and p-toluene are prepared continuously by ring chlorination of toluene in the presence of at least one catalyst in parallel flow with intensive mixing. Chlorine and toluene are employed in a molar ratio 0.4 to 1.0 and reacted in a reaction zone at 5 DEG to 70 DEG C. After the reaction, hydrogen chloride and unreacted toluene are distilled off. The bottom product is immediately separated into the o- and p-chlorotoluene isomers. The resulting toluenes can be used as solvents or as starting materials and intermediates.
[GB1497015A]
Patent IE-41747-L (IE)
Title: Food binding agent
IPC: A23L21/12
Filed: 1975-10-06
Abstract: The invention relates to food products having a gelled or thickened aqueous phase, a pH value of 2.5 up to 5.0 and in the case of milk products up to the neutral range about 7.5. Applicants have found unexpected benefit in using crude pectinaceous material of which the degree of esterification is or has been reduced to less than 20%, and preferably less than 10%, as the thickening or gelling agent in such products. Gel strength measurements show that comparable gels are formed with much lower pectin concentrations when the crude material is used than when purified or extracted pectin is employed. Gel structures are better and there is an outstanding cost advantage. Products contain from 0.1 to 20% crude pectinaceous material such as comminuted citrus peel. They may contain comminuted animal or vegetable protein or fruit puree or other flavoring at a pH of 2.5 to 5.0. Alternatively they may contain milk or milk derivatives, for example, from 2 to 60% milk solids and may have an acidic pH in the case of yoghurts or a pH up to about 7.5 in the case of ice cream, desserts or other milk products.[US4143172A]
Patent IE-43776-L (IE)
Title: 2-(4-substituted phenyl)-3-halo-cycloalkano-pyrazoles
IPC: C07D231/56
Filed: 1976-10-15
Abstract: 1519906 Herbicidal compositions E I DU PONT DE NEMOURS & CO 14 Oct 1976 [15 Oct 1975 12 Dec 1975 26 Aug 1976] 42776/76 Heading A5E [Also in Division C2] Herbicidal compositions comprise novel compounds of formula wherein n=3, 4 or 5; R 1 is H or CH 3 ; Q is F, Cl, Br or I; X is F, Cl, Br, I, CN, OCH 3 or NO 2 ; Y is H, F or Cl; Z is H or F and V is H, F, Cl or OCH 3 , with the provisos (a) that when n=5, R 1 =H, Q=Cl or Br, Z=V=H and Y=H or F; (b) when n=3 or 4 and Q=F or I, R 1 =Z=V=H and Y= H or F; (c) when n=3 and R 1 =CH 3 , Q=Cl or Br, Y=H or F and Z=V=H and (d) when V#H, X=F, Cl or Br and Z=H, together with one or more known herbicides as listed (see Example 22) and at least one of (a) a surface active agent and (b) a solid or liquid diluent.
[GB1519906A]
Patent IE-802351-L (IE)
Title: Antiarrhythmic tetrahydronaphthalene derivatives
IPC: C07D295/18
Filed: 1980-11-12
Abstract: Compounds are provided having the structure <CHEM> wherein R<1> and R<2> may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R<1> and R<2>together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R<3> and R<4> may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment of arrhythmia. In addition novel intermediates are provided having the structure <CHEM> wherein R is hydrogen, benzyl or <CHEM> These intermediates are also useful in treating acute myocardial infarction.
[EP0028940A1]
Patent IE-822811-L (IE)
Title: (+)-2-£1-(2,6-dichlorophenoxy)-ethyl|-1,¹3-diazacyclopent-2-ene
IPC: C07D233/22
Filed: 1982-11-25
Abstract: This invention relates to (+)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and to pharmaceutically acceptable acid addition salts thereof and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine, using these compounds.
Patent IE-893364-L (IE)
Title: Novel o-(3-amino-2-hydroxypropyl)-hydroximic acid halides¹and process for preparing the same
IPC: C07D295/12
Filed: 1989-10-19
Abstract: The present invention relates to novel hydroximic acid halides, the preparation of the same, pharmaceutical compositions containing the above novel compounds as active ingredients as well as the use of the said compounds in the therapy of diabetic angiopathy. The novel hydroximic acid derivatives are illustrated by the general formula (I), wherein X is halo, such as fluoro, chloro, bromo and iodo; R<1> is hydrogen or C1-5alkyl; R<2> is C1-5alkyl, C5-7cycloalkyl or phenyl optionally substituted with hydroxy, or R<1> and R<2>, when taken together with the adjacent nitrogen, form a 5 to 8 membered ring optionally containing additional nitrogen and/or oxygen atom, which ring may also be condensed with a benzene ring; R<3> is hydrogen, phenyl, naphthyl or piridyl optionally substituted with one or more halo or alkoxy; R<4> is hydrogen or phenyl; R<5> is hydrogen or phenyl; m is 0, 1 or 2 and n is 0, 1 or 2.
[WO9004584A1]