Patent SG-11201811363Y-A (SG)
Title: Anti-zika virus antibodies and methods of use
Inventor: KYRATSOUS CHRISTOS
IPC: C07K16/18
Filed: 2017-07-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111110101110111111101111111111011110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/017497 Al 25 January 2018 (25.01.2018) WIP0 I PCT (51) International Patent Classification: William; 777 Old Saw Mill River Road, Tarrytown, NY C07K 16/18 (2006.01) A61K 39/00 (2006.01) 10591 (US). MASON, Peter; 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (21) International Application Number: PCT/US2017/042447 (74) Agent: TERMES, Lance, A.; Schwabe Wiiliamson & Wy- (22) International Filing Date: att, PC, 1211 SW 5th Avenue, Suite 1900, Portland, OR 17 July 2017 (17.07.2017) 97204 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/363,546 18 July 2016 (18.07.2016) US DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, 62/474,753 22 March 2017 (22.03.2017) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant: REGENERON PHARMACEUTICALS MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, NY 10591 (US). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: KYRATSOUS, Christos; 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). OLSON, Title: ANTI-ZIKA VIRUS ANTIBODIES AND METHODS OF USE = (54) = ADE:. D2: :16 :DilutI - rt = = = = = _ _ = -40- REGN4203 NgG I) .6 REGN4204 t)igCi453, 'lir REGN4206 (;Icji4ki) = = Virus oozy — , = _ 40 = F1GURE1 1-1 IN C:N (57) : The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glyco- 71' N proteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for - inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. In some embod- --.... © iments, the invention provides for use of one or more antibodies that bind to the ZIKV for preventing viral attachment and/or entry into Ot host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination 1-1 © with one or more other anti-viral agents or vaccines. ei C [Continued on next page] WO 2018/017497 Al IMEDIMOM0101011MERI00 IIMMEHR0EUVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))