Patent SG-11201804671S-A (SG)
Title: Aza-benzimidazole inhibitors of pad4
Inventor: DEVRAJ RAJESH
IPC: C07D487/04
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ristsplid (43) International Publication Date .... .....r .,„.1 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO 1111111111111111111111111111 International III 2017/100601 Publication IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII Al Number (51) International Patent Classification: TON, Ian; 114 Innovation Drive, Milton Park; Abingdon A61K 31/4188 (2006.01) CO7D 235/00 (2006.01) Oxfordshire OX14 4RZ (GB). A61K 31/407 (2006.01) CO7D 471/04 (2006.01) CO7D 209/00 (2006.01) CO7D 487/04 (2006.01) (74) Agents: REID, Andrea L.C. et al.; One International Place, 40th Floor, 100 Oliver Street, Boston, Massachu- (21) International Application Number: setts 02110-2605 (US). PCT/US2016/065865 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 9 December 2016 (09.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/264,919 9 December 2015 (09.12.2015) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: PADLOCK THERAPEUTICS, INC. RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [US/US]; Route 206 & Province Line Road, Princeton, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, New Jersey 08543-4000 (US). ZA, ZM, ZW. (72) Inventors: DEVRAJ, Rajesh; 301 Palomino Hill Court, (84) Designated States (unless otherwise indicated, for every Chesterfield, Missouri 63005 (US). KUMARAVEL, Gna- kind of regional protection available): ARIPO (BW, GH, nasambandam; 21 Appletree Lane, Lexington, Massachu- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, setts 02420 (US). GLEAVE, Laura; 114 Innovation TJ, TM), European AT, BE, BG, CH, CY, CZ, DE, Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (AL, KOTEY, Adrian; 114 Innovation Drive, Milton DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (GB). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Park; Abingdon Oxfordshire OX14 4RZ (GB). KRULLE, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Thomas; 114 Innovation Drive, Milton Park; Abingdon GW, KM, ML, MR, NE, SN, TD, TG). Oxfordshire OX14 4RZ (GB). LECCI, Cristina; 114 In- novation Drive, Milton Park; Abingdon Oxfordshire OX14 Published: 4RZ (GB). TYE, Heather; 114 Innovation Drive, Milton — with international search report (Art 21(3)) Park; Abingdon Oxfordshire OX14 4RZ WIGGIN- (GB). 1-1 .4t 11 C::: , 0 0 1-1 IN 1-1 0 ei (54) Title: AZA-BENZIMIDAZOLE INHIBITORS OF PAD4 ci ) (57) : The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treat- ing PAD4-related disorders.