baber/WOPTO huggingface dataset:
Patent DE-60210329-T2 (DE)
Inventor: GERONI CRISTINA
IPC: A61K31/40
Filed: 2002-12-18
Granted: 2006-11-30
Abstract: The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
Patent DE-60214898-T2 (DE)
Inventor: ADEDEJI ADEYINKA
IPC: C08L101/00
Filed: 2002-07-08
Granted: 2007-09-13
Abstract: A thermoplastic composition comprises a compatibilized poly(arylene ether)/polyamide resin blend and a dendritic polyester resin.
Patent DE-60216744-T2 (DE)
Inventor: VINCI N
IPC: C10N20/04
Filed: 2002-03-18
Granted: 2007-11-08
Abstract: A lubricating oil composition comprising an oil of lubricating viscosity and a total of from about 1 to about 50% by weight of copolymers comprising (A) at least one ethylene-aliphatic olefin copolymer wherein the aliphatic olefins contain from 3 to about 24 carbon atoms, said copolymer (A) having Mn ranging from about 600 to about 5000, and (B) at least one copolymer comprising units derived from alkyl acrylate ester monomers containing from 2 to about 25 carbon atoms in the ester group, and optionally, from about 0.1% to about 20% by weight of at least one member of the group consisting of vinyl aromatic monomers and nitrogen-containing vinyl monomers. said copolymer (B) having Mn ranging from about 10,000 to about 350,000, wherein the weight ratio of (A):(B) ranges from about 99:1 to about 1:99.
Patent DE-60219602-T2 (DE)
Inventor: YAO YUAN
IPC: H02P9/10
Filed: 2002-02-07
Granted: 2008-01-03
Abstract: A generator control unit (200) includes a field current modulator (212) that repeatedly switches between an ON state and an OFF state to control the flow of field current to the generator (20), a free-wheeling path (216) that feeds excitation current from the generator (20) back to the generator (20) as a field current component when the field current modulator (212) is in the OFF state, and an impedance circuit (220) that selectively and temporarily absorbs excitation current in the free-wheeling path (216) to reduce voltage overshoot of the generator (20) upon occurrence of an operating transition, such as a transition from high load to low load. In one implementation, the impedance circuit (220) is an RC circuit and a by-pass switch (222) is provided across the RC circuit. When excitation current in the free-wheeling path (216) is not to be absorbed by the RC circuit, the by-pass switch (222) is ON, thereby providing a low-impedance path for the excitation current. A by-pass driver (230) controls the by-pass switch (222) to change the by-pass switch (222) from ON to OFF based on one or more detection signals, e.g., indicating a load transition or power-up, thereby introducing the impedance circuit (220) into the free-wheeling path (216) to effect decay of the excitation current from the generator (20).
Patent DE-60220779-T2 (DE)
Inventor: BARONI MARCO
IPC: A61P19/08
Filed: 2002-04-19
Granted: 2008-03-06
Abstract: The present invention relates to compounds of formula (I): in which X represents N or CH; R<SUB>1 </SUB>represents a hydrogen or halogen atom or a CF<SUB>3 </SUB>group; R<SUB>2 </SUB>and R<SUB>3 </SUB>independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents an optionally substituted nitrogenous heterocycle; and to their N-oxides and to their salts or solvates, to the pharmaceutical compositions and the medicaments comprising them, and to a process for their preparation.
Patent DE-60320349-T2 (DE)
Inventor: TOUZAIN JEAN-PHILIPPE
IPC: E05F3/10
Filed: 2003-06-25
Granted: 2009-07-30
Abstract: The door closer comprises a casing containing a hydraulic fluid in which a piston with a skirt slides with a sealing joint and delimits two chambers. Movements of the piston relative to the casing are fixed to those of the door leaf. A return spring is supported against the piston skirt to return the piston to its door closing position. A conduit connecting the two chambers ensures fluid transfer between them. The door is locked in the open position by a locking spindle (27) and a retractable stop which limits the travel of the piston. The locking spindle can translate in a ball carrying sheath (29) provided with a holder (31) for balls (34) pressed against the locking spindle.
Patent DE-68909766-T2 (DE)
Inventor: PLANCHARD CHRISTIAN
IPC: B65B9/02
Filed: 1989-12-29
Granted: 1994-04-28
Abstract: Method for the manufacture of individual sachets of any shape and each containing an individual dose of an active product in which: -  two films (10, 11) from which the sachet is to be formed, are unrolled, the facing surfaces of these films being such that they can be heat-welded, -  the two films are brought substantially into contact with each other on each side of a unit (15) for depositing a product disposed between the two films which are heat-welded by two shaped heating plates (18, 19), -  the united sheet (20) is displaced towards a punch-type station cutting separate sachets (33) from the sheet (20), the contour of the punch and of the die respectively being shaped and arranged in such a way as to cut the sheet (20) around the volume (16) containing the product and the cutting-out taking place only in the areas of the sheet where the two films are heat-welded. <IMAGE>
Patent DE-68910051-T2 (DE)
Inventor: MCANALLEY BILL
IPC: A61K36/00
Filed: 1989-01-12
Granted: 1994-05-05
Abstract: A process is described for extracting a pharmaceutically active polysaccharidic substance from the aloe plant. The pharmaceutically active polysaccharidic substance and its characteristic properties are described.
Patent DE-68911944-T2 (DE)
Inventor: SCHNETTLER RICHARD
IPC: C07D263/38
Filed: 1989-02-14
Granted: 1994-05-19
Abstract: Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
Patent DE-68920520-T2 (DE)
Inventor: BARTHOLE JEAN-PIERRE
IPC: C07C59/215
Filed: 1989-09-11
Granted: 1995-05-24
Abstract: Process for separating 2-keto-L-gulonic acid from a fermentation liquor chiefly containing the calcium salt of 2-keto-L-gulonic acid, by carrying out the following successive operations: 1) separation of the insoluble matter, 2) demineralisation of the filtered liquor, and 3) separation of the 2-keto-L-gulonic acid.
Patent DE-68924130-T2 (DE)
Inventor: GLERIA MARIO
IPC: C08G79/025
Filed: 1989-11-14
Granted: 1996-02-01
Abstract: Polyphosphazene derivatives containing carbonyl groups apt to undergo rapid photoreticulation processes having the general formula <CHEM>  in which: X represents substituents bound to the polyphosphazene chains by means of hydroxy or amino functions, and containing carbonyl groups; X min  represents additional substituents bound to the polyphosphazene chain through hydroxy or amino functions and containing one or more easily extractable hydrogen atoms;  (w + y + z) is an integer between 20 and 15.000; w z are integers higher than or equal to 0 and always lower than 15.000; y is an integer between 20 and 15.000. n
Patent DE-69004865-T2 (DE)
Inventor: CARNEL ALAIN
IPC: G01R21/00
Filed: 1990-05-31
Granted: 1994-04-14
Abstract: The invention relates to an input circuit for an electrical energy meter, which circuit has a current path and a voltage path, the current path being associated with a mutual conductance transformer. In order to compensate for the differentiating function of the transformer, but without introduicng interference signals, the current path includes an active filter connected as an integrator and provided with a coupling capacitance suitable for blocking low frequency signals.
Patent DE-69009488-T2 (DE)
Inventor: PERSSON BJOERN
IPC: B26B3/02
Filed: 1990-10-12
Granted: 1994-09-29
Abstract: PCT No. PCT/SE90/00655 Sec. 371 Date Apr. 13, 1992 Sec. 102(e) Date Apr. 13, 1992 PCT Filed Oct. 12, 1990 PCT Pub. No. WO91/05638 PCT Pub. Date May 2, 1991.A butter knife having a knife blade (10) and a handle (16) is configured at the junction between blade and handle with a transverse channel (26) whose side walls (20, 22) are substantially parallel and disposed perpendicularly to the blade. The rear wall (22) has a vertical extension which is approximately twice the vertical extension of the front wall (20), so as to form a stop when the knife blade is moved slidingly inwards on the rim (34) of a plastic tray (22) having a folded edge. The width of the chann el is such as to enable the channel to be pressed over the tray rim so as to clamp the knife firmly in a substantially horizontal position when the tray is placed on a table.
Patent DE-69009721-T2 (DE)
Inventor: CHARMOT DOMINIQUE
IPC: C08G77/22
Filed: 1990-12-20
Granted: 1994-12-08
Abstract: Magnetisable composite microspheres made up of a core consisting of magnetisable fillers distributed uniformly in a lattice of a polysilsesquioxane (SiVi) containing ethylenic unsaturations and a skin made of a crosslinked organosilicon polymer derived from the hydrosilylation of an organohydropolysiloxane (SiH) with the ethylenically unsaturated groups of the polysilsesquioxane SiVi. 
<??>They are obtained by dispersion in a solvent of an aqueous suspension of magnetisable fillers not coated with dispersing agent, dissolving of an alkoxysilane or of an alkoxysiloxane containing ethylenic unsaturations, polycondensation to a polysilsesquioxane SiVi, removal of water, dissolving of the SiH polymer in the organic phase, crosslinking, removal of water, isolation of the microspheres and optionally redispersion in water. 
<??>Use as active support in biology.
Patent DE-69013766-T2 (DE)
Inventor: ROBERTS DAVID ALAN
IPC: A01N47/02
Filed: 1990-06-15
Granted: 1995-04-06
Abstract: The invention provides N-phenylpyrazole derivatives of the formula:   <CHEM> wherein R<1> represents alkyl optionally substituted by halogen, R<2> represents alkyl, alkenyl or alkynyl optionally substituted by halogen, R<3> represents a phenyl group substituted in the 2-position by halogen; in the 4-position by optionally halo substituted alkyl or alkoxy; and optionally in the 6-position by halogen; and m and n are independently 0, 1 or 2; which are active against arthropod, plant nematode, helminth and protozoal pests.
Patent DE-69015147-T2 (DE)
Inventor: LIFER SHERRYL LYNN
IPC: C07D405/12
Filed: 1990-11-28
Granted: 1995-05-24
Abstract: This invention provides phenyl and heterocyclic derivatives of the formula <CHEM>  or a pharmaceutically acceptable salt or solvate thereof <CHEM>  each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3;  R2 is C4-C7 straight chain alkyl;  each R3 is independently -OH, -COOH, or 5-tetrazolyl;  each n is independently 0, 1, 2, 3, or 4; R4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido;  Q is a bond or -O-; and  w is H, methyl, ethyl, or hydroxy. Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.
Patent DE-69016765-T2 (DE)
Inventor: HAZARD MICHEL
IPC: G06F7/58
Filed: 1990-12-18
Granted: 1995-06-22
Abstract: PCT No. PCT/FR90/00923 Sec. 371 Date Aug. 9, 1991 Sec. 102(e) Date Aug. 9, 1991 PCT Filed Dec. 18, 1990 PCT Pub. No. WO91/09381 PCT Pub. Date Jun. 27, 1991.In a data processing system using portable objects (1) such as cards incorporating memory chips (11, 12, 13, 14, 15) and a processing circuit (10), where a first memory zone (11) is electrically erasable and writable at the request of the processing circuits in the object, random numbers are generated taking into account a first parameter taken from the first zone (11) and at least one second parameter written in a second, nonvolatile zone (12) of the object, the content of this second zone being modified each time the first zone is erased such that the combination of parameters is never identical following the various erase operations on the first zone.
Patent DE-69019362-T2 (DE)
Inventor: STRID KENT
IPC: B01D33/23
Filed: 1990-09-24
Granted: 1995-11-02
Abstract: PCT No. PCT/SE90/00609 Sec. 371 Date Feb. 28, 1992 Sec. 102(e) Date Feb. 28, 1992 PCT Filed Sep. 24, 1990 PCT Pub. No. WO91/04090 PCT Pub. Date Apr. 4, 1991.A filter sector for a filter disk of a rotating filter, including folded or currugated means having ridges and valleys extending in a longitudinal direction of said means to form filtrate channels, and a filtering medium covering said means. Said means includes at least two elements (9, 10), each having parallel riges (12, 11') and valleys (11, 12') and said at least two elements are located in an at least partly overlapping relationship, such that filtrate channels (13) of one element (9) intersect with filtrate channels (14) of the other element (10). Preferably, the filter sector includes two at least substantially equally shaped elements and said elements are disposed such that there is communication between filtrate channels (13, 14) of said elements (9, 10) in zones of said partly overlapping relationship.
Patent DE-69026742-T2 (DE)
Inventor: CULLEN WALTER PATRICK
IPC: A23K20/195
Filed: 1990-02-07
Granted: 1996-09-19
Abstract: An antibiotic, prepared by fermentation of Streptomyces sp. ATCC 53862, of the formula:- <CHEM> wherein Me=CH3 and Pr=CH3CH2CH2, or a pharmaceutically acceptable cationic salt thereof. The antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
Patent DE-69029645-T2 (DE)
Inventor: CAMMILLI LEONARDO
IPC: A61M25/00
Filed: 1990-11-17
Granted: 1997-04-24
Abstract: The invention provides an automatic implantable defibrillator with the following essential characteristics: a) a circuitry (1,2,3,6,7,8) for reliable recognition of a ventricular fibrillation state b) a paumaker (5) for trying to stop the fibrillation if it is an asystole c) if not, effecting defibrillation not by electrical pulses fed to the heart but by a bolus of medicaments (or solutions under particular physical conditions, such as a cold bolus at 30 DEG C) fed by a hydraulic system (12) into the coronary sinus or into a coronary artery by a retrograde path, to rapidly pervade the coronary circuit.
Patent DE-69106871-T2 (DE)
Inventor: BRANCO DA SILVA ALCIDES
IPC: C07C409/26
Filed: 1991-02-22
Granted: 1995-06-14
Abstract: PCT No. PCT/BR91/00002 Sec. 371 Date Sep. 22, 1992 Sec. 102(e) Date Sep. 22, 1992 PCT Filed Feb. 22, 1991 PCT Pub. No. WO91/13059 PCT Pub. Date Sep. 5, 1991.The production of dilute equilibrium, storage stable solutions of peracetic acid from mixtures of aqueous hydrogen peroxide and acetic acid, or by dilution of more concentrated peracetic acid solutions, takes a long time because of the low concentrations of the active participating materials. The process can be accelerated by employing a two step procedure in which a concentrated peracetic acid solution is diluted with water and partially hydrolysed in the first step, and then the hydrolysis reaction is quenched by addition of hydrogen peroxide in the second step.
Patent DE-69109662-T2 (DE)
Inventor: FERLA GUILLERMO
IPC: H04N1/06
Filed: 1991-09-18
Granted: 1995-09-07
Abstract: A printing system employs a rotating drum for carrying a photosensitive printing medium in the form of a discontinuous sheet, there being a clamp carried by the drum and rotating therewith for holding ends of the sheet to secure the sheet to the drum. The system includes a print head having a laser beam which is spatially and temporally modulated for gray-scale printing of individual pixels of an image. The head is scanned parallel to an axis of the drum. A servomechanism responsive to angular orientation of the drum produces a linear scan during rotation of the drum. An optical system within the head provides a common path through a common objective lens for both a write laser beam and for a focus laser beam of an automatic focusing apparatus which positions the objective lens rapidly by a dither motion to compensate for undulations in the surface of the print medium. The objective lens is carried at a reference position during passage of the clamp, the reference position being updated periodically by measurements of focus.
Patent DE-69111882-T2 (DE)
Inventor: SHIMOKAWA SATORU
IPC: H01L31/0232
Filed: 1991-05-03
Granted: 1996-05-02
Abstract: A light-emitting element (3) is constructed by molding a semiconductor chip (1) of a light-emitting diode in a resin (2). A condensing lens (5) is secured to the molded resin (2) with its optic axis in alignment with the optic axis of the semiconductor chip (1). The light-emitting element (3) is used in order to produce projected light in an photoelectric switch. <IMAGE>   <IMAGE>
Patent DE-69118042-T2 (DE)
Inventor: GULOTTA JOSEPH ANTHONY
IPC: C03C4/08
Filed: 1991-07-24
Granted: 1996-11-21
Abstract: A green tinted, ultraviolet absorbing glass is obtained by the addition of colorant to a standard soda-lime-silica base glass composition and a colorant includes less than 0.5 weight percent of cerium oxide (CeO2), greater than 0.85 weight percent of total iron expressed as Fe2O3 and a ratio of ferric iron expressed as FeO to total iron of less than 0.275. The glass has a low ultraviolet transmittance, viz., no greater than 31 percent over the wavelength range of 300 to 390 nanometers at a reference glass thickness of 3.9 millimeters. An advantage of the glass of this invention over competing ultraviolet absorbing glass is the use of larger amounts of total iron and smaller proportions of iron in the ferrous state to obtain the low ultraviolet transmittance. In this manner, the amounts of cerium oxide which is expensive is reduced.
Patent DE-69118630-T2 (DE)
Inventor: CORBY MICHAEL PETER
IPC: G01N33/04
Filed: 1991-08-22
Granted: 1996-10-02
Abstract: A method for the determination of the somatic cell content of milk comprising mixing the milk with hydrogen peroxide and measuring the evolution of gas, characterised in that the gas evolution is measured using a capillary tube is disclosed.
Patent DE-69119400-T2 (DE)
Inventor: HERSLOEF BENGT
IPC: A61K47/44
Filed: 1991-09-24
Granted: 1996-12-05
Abstract: The invention relates to a lipid particle forming matrix, characterized by, that from a defined system of at least two lipid components chosen from classes of different polarity, in which at least one of the lipid components is bilayer forming, discrete lipid particles are formed spontaneously when interacting with aqueous systems. Preferably at least one of the lipid components is amphiphatic and polar and one is nonpolar. These discrete particles are formed spontaneously from the matrix without any chemical or physical treatment or initiation. The lipid particle forming matrix can contain bioactive materials, chosen from the group of drugs, herbicides, pesticides, fertilizers, food and cosmetic ingredients or additives. The invention also relates to a process for the production of the matrix, the use of the lipid particle forming matrix as a carrier system for bioactive materials and pharmaceutical composition such as oral, rectal, nasal, vaginal, ocular or parenteral vehicles, creams, ointments, capsules and tablets containing the said lipid particle forming matrix and a drug.
Patent DE-69119530-T2 (DE)
Inventor: FILIPI CHARLES JOSEPH DR
IPC: A61B17/115
Filed: 1991-10-10
Granted: 1996-09-26
Abstract: A technique for invaginating the esophagus (20) at the gastroesophageal junction (10) is disclosed, as well as an invagination device (70) useful in the described technique. The invagination device includes an introducer guide (75) which has an outside diameter approximating that of the esophagus and a plurality of needle-receiving lumens (78) extending to its outer diametric surface. The invagination device also has an engagement assembly which includes 10 needles (88), each having a retracted position in which they lie within the needle-receiving lumens of the introducer guide, and an extended position in which they extend out of the lumens and project radially from the guide for engagement with the esophagus at the gastroesophageal junction. The invagination device is introduced transorally into the esophagus, its engagement assembly is activated to place the needles in their extended position in engagement with the esophagus, and the engaged invagination device is advanced the toward the stomach to fold the attached esophagus beyond the gastroesophageal junction. A remotely operable fastening assembly (50), which has been introduced into the stomach through an operating channel/insufflation port, is then operated to fasten the invaginated gastroesophageal junction to the surrounding involuted fundic wall. Finally, the needles are retracted back into their needle-receiving lumens and the invagination device and the fastening assembly are removed from the body of the patient. This minimally-invasive technique accomplishes the formation of a new valve between the esophagus and stomach, thus preventing acid reflux.
Patent DE-69121881-T2 (DE)
Inventor: GROSS JOSEPH
IPC: A61N1/30
Filed: 1991-12-13
Granted: 1997-04-03
Abstract: A transdermal drug delivery device includes an electrode, a porous insulating layer on one side of the electrode and impregnated with a liquid containing the drug to be delivered, a reservoir for the liquid on the other side of the electrode, and a displaceable diaphragm controlling the feeding of the liquid from the reservoir to the porous insulating layer via a passageway through the electrode.
Patent DE-69122751-T2 (DE)
Inventor: CALANCHI MASSIMO MARIA
IPC: A61K31/606
Filed: 1991-04-09
Granted: 1997-02-13
Abstract: The invention provides pharmaceutical compositions with the property of targeted controlled release of active principles which act pharmacologically within the intestine and in particular within the colon and the terminal portion of the ileum. To attain this object the active principle is prepared in multiparticle multidose form and is covered with at least two membranes, one of pH-dependent solubility and the other insoluble but permeable to the intestinal fluids. While the covered active principle remains in the stomach and in the initial intestinal portion, ie while the pH is less than 5.5, it is not released. Only when it reaches an environment of higher pH (small intestine or colon) does the pH-dependent membrane dissolve to commence release of the active principle. From this moment the second membrane, which is pH-independent but permeable to the intestinal fluids, acts to slow down and control the dissolution of the medicament within the small intestine-colon tract.
Patent DE-69127076-T2 (DE)
Inventor: MOHN FRANK
IPC: E21B17/00
Filed: 1991-03-27
Granted: 1998-01-02
Abstract: PCT No. PCT/GB91/00464 Sec. 371 Date Nov. 4, 1992 Sec. 102(e) Date Nov. 4, 1992 PCT Filed Mar. 27, 1991 PCT Pub. No. WO91/15654 PCT Pub. Date Oct. 17, 1991.Material is thermally extracted from an underground formation with the aid of heat supplied by electrical resistance heaters (21) or by tubing (5, 6) serving as such, or by heated fluid conveyed downhole in pipes (12), which may serve as electrical conductors, or as resistance heaters, or which may be heated downhole. The fluid may be circulated upwardly after passage through a downhole pump unit where the fluid is suitable.
Patent DE-69130695-T2 (DE)
Inventor: MATSUO HISAYUKI
IPC: A61K38/22
Filed: 1991-09-06
Granted: 1999-06-10
Abstract: A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable for a diagnostic reagent. The novel peptide is manufactured by the procedure of genetic engineering as well as by the methods of purification from frog brains or by chemical synthesis.
Patent DE-69200242-T2 (DE)
Inventor: KUZNITZ MATTHEW
IPC: A61K8/30
Filed: 1992-01-28
Granted: 1994-11-24
Abstract: A clear gel composition is provided which includes a polyhydric alcohol, a soap, an alkoxylate copolymer and a fragrance. For purposes of maintaining clarity, the fragrance will contain at most 25% of total ester compounds by weight of the fragrance.