baber/WOPTO huggingface dataset:
Patent CO-5601011-A2 (CO)
Title: Derivados de 3-ciclil-5-(anillo de 5 miembros que contiene nitrogeno) metil-oxazolidinona y su uso como agentes antibacterianos
Inventor: GRAVESTOCK MICHAEL BARRY
IPC: C07D417/14
Filed: 2004-08-25
Abstract: 1.- Un compuesto de fórmula (I), ó una sal farmacéuticamente aceptable, ó un éster hidrolizable in vivo de éste, en donde -N-HET se selecciona de las estructuras (la) a (If) siguientes:en donde u y v son independientemente 0 ó 1;R1 es un grupo alquil C1-C4;Q se selecciona de Q1 a Q6:en donde R2 y R3 son independientemente seleccionados entre H, F, Cl, CF3, OMe, SMe, Me y Et, en donde B1 es O ó S;en donde T se selecciona de los grupos de (TA) hasta (TE) siguientes (en donde AR1, AR2, AR2a, AR2b, AR3, AR3a, AR3b, AR4, AR4a, CY1 y CY2 se definen más adelante); ...
Patent CO-5580758-A2 (CO)
Title: Indoles utiles en el tratamiento de enfermedades relaciona das con androgenos receptores
Inventor: NEELTJE MIRANDA TEERHUIS
IPC: C07D403/06
Filed: 2005-06-02
Abstract: 1.- Un compuesto que tiene la formula Donde X es S, SO o SO2 R1 es una estructura anular no saturada o saturada, monociclica, hetero u homociclica, de 5- o 6- miembros opcionalmente sustituida con uno o mas sustituyentes seleccionados de los grupos de halógenos, CN, (1C-4C)fluoroalkil, nitro, (1C-4C)alkil, (1C-4C)alkoxi o (1C-4C)fluoroalkoxi.R2 es 2-nitrofenil, 2-cianofenil, 2-hidroximetil-fenil, piridina-2-il, piridina-2-il-N-oxido, 2-benzamida, metil ester del ácido 2-benzoico o 2-metoxifenil;R3 es H, halógeno o (1C-4C)alkil;R4 es H, OH, (1C-4C)alkoxi o halógeno;R5 es H, OH, (1C-4C)alkoxi; NH2, CN, halógeno, (1C-4C)fluoroalkil, NO2, hidroxi (1C-4C)alkil, CO2H, CO2(1C-6C)alkil, o R5 es NHR6, donde R6 es (1C-6C)acil opcionalmente sustituido con uno o mas halógenos, S(O)2(1C-4C)alkil, o S(O)2aril opcionalmente sustituido con (1C-4C)alkil o uno o más halógenos.R5 es C(O)N(R8 o R9) donde R8 y R9 cada uno independientemente son H,(3C-6C)cicloalkil, o CH2R10, donde R10 es H, (1C-5C)alkil, (1C-5C)alkenil, hidroxi(1C-3C)alkil, (1C-4C)alkilester de carboxi(1C-4C)alkil, (1C-3C)alkoxi(1 C-3C)alkil, (mono o di(1C-4C)alkil)aminometil, (mono- o di(1C-4C)alkil)aminocarbonil, o un anillo no aromático o aromático, monociclico, hetero u homocíclico, de 3-, 4-, 5- o 6- miembros o R8 y R9 forman conjuntamente con el N un anillo no saturado o saturado, heterocíclico de 5 o 6 miembros opcionalmente sustituido con (1C-4C)alkil; o una sal o forma hidratada a partir de ellos.2.- Un compuesto de acuerdo con la reivindicación 1, caracterizado en que R1 es una estructura anular no saturada o saturada, monociclica, hetero u homociclica de 5- o 6-miembros, opcionalmente sustituida con uno o mas sustituyentes seleccionados del grupo de halógeno, CN, CF3, nitro, metoxi, trifluorometoxi o metil;R2 es 2-nitrofenil, 2-cianofenil, 2-hidroximetil-fenil, piridina-2-il, piridina-2-il-N-oxido, 2-benzamida, 2- metil éster de ácido benzoico o 2-metoxifenil; R3 es H, halogeno o (1 C-2C)alkil; R4 es H o F.
Patent CO-6251358-A2 (CO)
Title: Aspartato de acido -ciclopropil-6
Inventor: RYU JEI MAN
IPC: A61P31/00
Filed: 2009-10-27
Abstract: Se describen sales de ácido aspártico de ácido 1-ciclopropil-6--fluoro-7-(8-metoxiimino-26-diaza-espiro [3.4]oct-6-il)-4-oxo-1,4-dihidro-[1,8]naftiridina-3-carboxílico, métodos para preparar el mismo, y composiciones farmacéuticas antimicrobianas que comprenden el mismo. 1.- Una sal de ácido aspártico del ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diaza-espiro[3.4]oct-6-il)-4-oxo-1,4-dihidro-[1,8]naftiridina-3-carboxílico representada por la Fórmula (I):2.- La sal de ácido aspártico del reivindicación 1, en donde el ácido aspártico se selecciona de ácido D-aspártico, ácido L-aspártico, ácido DL-aspártico o una mezcla no racémica de ácido D-aspártico y ácido L-aspártico. 3.- Un método para preparar la sal de ácido aspártico del ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diaza-espiro[3.4) oct-6-il)-4-oxo-1,4-dihidro-[1 ,8]naftiridina-3-carboxílico de la reivindicación 1, que comprende una etapa de hacer reaccionar ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diaza-espiro[3.4]oct-6-il)-4-oxo-1,4-dihidro-[1,8]naftiridina-3-carboxílico con ácido aspártico en un disolvente. 4.- El método de la reivindicación 3, en donde el disolvente es por lo menos uno seleccionado del grupo que consiste de acetato de etilo, metanol, etanol, isopropanol, acetona, acetonitrilo, hexano, isopropil éter, y agua. 5.- El método de la reivindicación 3, en donde el ácido aspártico se selecciona de ácido D-aspártico, ácido L-aspártico, ácido DL-aspártico o una mezcla no racémica de ácido D-aspártico y ácido L-aspártico. 6.- Una composición farmacéutica antimicrobiana que comprende la sal de ácido aspártico del ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diaza-espiro[3.4]oct-6-il)-4-oxo-1,4-dihidro-[1,8]naftiridina-3-carboxílico.
Patent CO-6140024-A2 (CO)
Title: Uso de compuestos inhibidores de quinaxolina de pi3k-alfa para el tratamiento del cancer
Inventor: LAMB PETER
IPC: A61K31/337
Filed: 2009-11-09
Abstract: 1.- Uso de un compuesto de Fórmula I:o un isómero simple de éste, donde el compuesto está opcionalmente como una sal farmacéuticamente aceptable y en forma adicional opcionalmente como un hidrato y en forma adicional opcionalmente como un solvato de éste, para la fabricación de un medicamento caracterizado porque dicho medicamento es para el tratamiento del cáncer y contiene el compuesto de Fórmula I y al menos uno de un portador, excipiente o diluyente farmacéuticamente aceptable en combinación con, uno o más agentes quimioterapéuticos, una o más de las terapias hormonales, uno o más anticuerpos, una o más inmunoterapias, terapia de yodo radiactivo, y radiación donde el Compuesto de Fórmula I es este donde: W1, W2, W3, y W4 son -C(R1)=; o uno o dos de W1, W2, W3, y W4 son de modo independiente -N= y los restantes son (R1)=; y donde cada R1 es de modo independiente hidrógeno, alquilo, haloalquilo, nitro, alcoxi, haloalcoxi, halo, hidroxi, ciano, amino, alquilamino, o dialquilamino; R51 es hidrógeno o alquilo; R52 es hidrógeno o halo; R50, R53, y R54 son de modo independiente hidrógeno, alquilo, alquenilo, halo, haloalquilo, haloalquenilo, hidroxi, alcoxi, alqueniloxi, haloalcoxi, nitro, amino, alquilamino, dialquilamino, -N(R55)C(O)- alquilen C1-C6-N (R55a) R55b, alquilcarbonilo, alquenilcarbonilo, carboxi, alcoxicarbonilo, ciano, alquiltio, -S(O)2NR55R55a, o alquilcarbonilamino y donde R55 y R55b son de modo independiente hidrógeno, alquilo, o alquenilo y R55a es hidrógeno, alquilo, alquenilo, hidroxi, o alcoxi; o R53 y R54 junto con los carbonos a los que están unidos forman un heteroarilo de 5 o 6 miembros o heterocicloalquilo de 5 o 6 miembros; B es fenilo sustituido con R3a y opcionalmente también sustituido con uno, dos o tres R3; o B es heteroarilo opcionalmente sustituido con uno, dos o tres R3;R3a es ciano; hidroxiamino; carboxi; alcoxicarbonilo; alquilamino; dialquilamino; alquilcarbonilo; haloalcoxi; alquilsulfonilo; aminoalquiloxi; alquilaminoalquiloxi; ...
Patent CO-6351796-A2 (CO)
Title: Genes de toxinas y metodos para su uso
Inventor: AGARWAL SHRUTI
IPC: C07K14/325
Filed: 2010-12-15
Abstract: Se proporcionan composiciones y métodos para conferir actividad pesticida contra bacterias, plantas, células vegetales, tejidos y semillas. Se proporcionan composiciones que comprenden una secuencia codificadora para un polipéptido de delta-endotoxina. Las secuencias codificadoras pueden utilizarse en constructos de ADN o cassettes de expresión para transformación y expresión en plantas y bacterias. Las composiciones también comprenden bacterias, plantas, células vegetales, tejidos y semillas transformados. En particular, se proporcionan moléculas aisladas de ácido nucleico de delta-endotoxina. Adicionalmente, están comprendidas secuencias de aminoácidos que corresponden a los polinucleótidos y anticuerpos que se unen específicamente a dichas secuencias de aminoácidos. En particular, la presente invención prevé moléculas de ácido nucleico aisladas que comprenden una secuencia de nucleótidos que codifica la secuencia de aminoácidos que se muestra en cualquiera de SEQ ID NO:61-121 y 133-141, o una secuencia de nucleótidos que se indica en SEQ ID NO:1-60,124-132 y 142-283, así como también variantes y fragmentos de las mismas.
Patent CO-7131354-A2 (CO)
Title: Composiciones antitranspirantes emulsionadas y procesos para elaborarlas
Inventor: THOMPSON BEREA
IPC: A61K8/19
Filed: 2014-08-28
Abstract: COMPOSICIONES ANTITRANSPIRANTES EMULSIONADAS Y PROCESOS PARA ELABORARLASRESUMENComposiciones antitranspirantes emulsionadas. Procesos para elaborarlas. En una forma de realización, un proceso para elaborar una composición antitranspirante emulsionada comprende combinar agua y un componente antitranspirante activo, de modo tal de obtener una fase acuosa; combinar un vehículo hidrófobo y un estructurante, de modo tal de obtener una fase oleosa, donde el estructurante se caracteriza por un punto de fusión que es superior a la temperatura ambiente; calentar la fase oleosa a una primera temperatura, que al menos es igual al punto de fusión del estructurante que está presente en ella; mezclar la fase acuosa y la fase oleosa caliente, de manera tal de obtener una composición antitranspirante emulsionada; y enfriar la composición antitranspirante emulsionada, en presencia de una agitación continua.
Patent CO-7240369-A2 (CO)
Title: Ácido 5-aminotetrahidroquinolin-2-carboxílicos novedosos y su uso
Inventor: HAHN MICHAEL
IPC: C07D217/26
Filed: 2015-01-15
Abstract: La presente solicitud se refiere a ácidos 5-aminotetrahidroquinolin-2- carboxilicos novedosos, a procedimientos para su preparación, a su uso para el tratamiento y/o la prevención de enfermedades así como a su uso para la preparación de medicamentos para el tratamiento y/o la prevención de enfermedades, especialmente para el tratamiento y/o la prevención de enfermedades cardiovasculares y cardiopulmonares.
Patent CO-7200269-A2 (CO)
Title: Composiciones herbicidas que comprenden ácido 4amino3cloro5fluoro6(4cloro2fluoro3metoxifenil) piridin2carboxílico o uno de sus derivados e inhibidores de la 4hidroxifenilpiruvato dioxigenasa (hppd)
Inventor: YERKES CARLA N
IPC: A01N43/40
Filed: 2015-02-10
Abstract: Se proporcionan en la presente composiciones herbicidas sinérgicas y métodos de control de vegetación indeseable que utilizan (a) un compuesto de la fórmula (I):o una de sus sales o ésteres aceptables en agricultura y (b) HPPD inhibidores por ejemplo, benzobiciclona, benzofenap, ciclopirimorato, fenquinotriona, isoxaflutol, mesotriona, pirazolinato, sulcotriona, tefuriltriona y topramezona o su sal o éster. Las composiciones y métodos proporcionados en la presente proporcionan control de vegetación indeseable, por ejemplo, en arroz de siembra directa, arroz de siembra en agua, arroz trasplantado, cereales, trigo, cebada, avena, centeno, sorgo, maíz o maíz, caña de azúcar, girasol, colza oleaginosa, canola, remolacha, soja, algodón, ananás, hortalizas, pastos, praderas, pastizales, tierra de barbechos, césped, árboles y huertos de vides, cultivos de plantaciones, plantas acuáticas o control de vegetación industrial (IVM) o derechos de paso (ROW).
Patent EP-1043211-A2 (EP)
Inventor: TSUJIMOTO TAISUKE
IPC: B62D113/00
Filed: 2000-04-01
Abstract: Disclosed is a power steering apparatus (1) using an electric
motor (27) as a drive source. The power steering apparatus
includes a drive inhibiting circuit (30, S8) for inhibiting an
electric motor (27) from being driven when the temperature (T)
detected by a temperature sensor (34) is not less than an
upper-limit temperature (T3), a judging circuit (30, S10) for
judging, in a state where the electric motor (27) is inhibited
from being driven by the drive inhibiting circuit (30, S8),
whether or not the steering angle is included in a predetermined
steering angle midpoint range when the temperature sensor
(34) detects a temperature (T) which is not more than a lower-limit
temperature (T1), and a re-drive allowing circuit (30,
S11) for allowing, when it is judged that the steering angle is
within the steering angle midpoint range, the electric motor
(27) to be driven again.
Patent EP-1055998-A2 (EP)
Inventor: SINGH BALRAJ
IPC: G06F9/30
Filed: 2000-04-15
Abstract: A method and an apparatus for reducing the number of instruction transactions in a
microprocessor are disclosed. As a method, the number of issued instructions carried by an
issued instruction bus in a computer system are reduced by determining if an instruction
fetched by a fetch unit matches a cached instruction tag. When the fetched instruction
matches the cached instruction tag, an opcode and an associated instruction corresponding
to the cached instruction tag are directly injected to an appropriate function unit. The
apparatus includes a plurality of tag PC cache memory devices used to store tag PC entries
associated with target instructions injected directly to corresponding function units
included microprocessors and the like. The injection reduces the number of instructions
fetched from the program memory as well as the number of issued instructions carried by
an issued instruction bus.
Patent EP-1052174-A2 (EP)
Inventor: HAJEK HEINRICH
IPC: B65B57/00
Filed: 2000-04-28
Abstract: The packing machine has a machine body with deep-drawing molding point, insertion region, vacuuming and sealing point and a cutting point. The insertion region (6) is between the molding point (4) and the vacuuming and sealing point (10). The insertion region is protected against handling during the feed stroke.
Patent EP-1058416-A2 (EP)
Inventor: MARIGGIS ATHANASE
IPC: H04J3/06
Filed: 2000-05-26
Abstract: The device includes a control arrangement (ST) for emitting a bit sequence formed according to a phase difference between a first and second clock signal. The bit sequence is supplied to a clock generator (VCXO). The device includes devices for feeding back the second clock signal to the control arrangement, comprising an integrated control logic (CONTLOG). The control logic divides the bit sequence, using the second clock (CLOCK), into bit pairs, and replaces at consecutive appearance of two equal bit pairs which comprise different bits, i.e. "01" or "10", the later arriving bit pair through its inverted bit pair. The first clock (REF_CLOCK) is preferably a reference clock, and the second clock is a locally produced clock. The control arrangement includes preferably a phase detector (PD) and a coupled bit generator (PWM).
Patent EP-1069434-A2 (EP)
Inventor: EICHNER WOLFRAM DR
IPC: G01N33/72
Filed: 2000-07-12
Abstract: Use of hemoglobin derivatives (I) which are stable chromoproteins with a molecular weight of at least 64 kD to determine plasma and/or blood volume, is new. Independent claims are also included for a composition for determining plasma and/or blood volume, comprising a carbon monoxide (CO) complex of (I).
Patent EP-1081684-A2 (EP)
Inventor: KOYATA TOMOHIRO
IPC: H04B14/00
Filed: 2000-08-31
Abstract: A digital signal of which input data has been
segmented as block each having a predetermined data
amount and highly efficiently encoded along with an
adjacent block is decoded, edited, and then highly
efficiently encoded. A delay that takes place in such
signal processes is compensated. Thus, part of a
digital signal that has been highly efficiently encoded
digital signal can be edited.
Patent EP-1086922-A2 (EP)
Inventor: KIGAWA HIROSHI
IPC: B66B11/06
Filed: 2000-09-22
Abstract: A self-propelled elevator in which a drum type winding
machine 4 is attached to a cage 1, and the cage 1 is
elevated along guide rails 2 arranged in a hoistway 6 by a
first winding rope 5, one end of which is fixed to a top
portion of the hoistway 6 and the other end portion of
which is directly wound round a winding drum sheave 4a of
the drum type winding machine 4, the self-propelled
elevator is characterized in that: the drum type winding
machine 4 is attached onto a lower side of a bottom portion
of the cage 1 so that an end face of the winding drum
sheave 4a round which the first winding rope 5 is wound can
be located outside a projected region of the cage 1 in the
perpendicular direction.
Patent EP-1086876-A2 (EP)
Inventor: SUZUKI YOSHIYUKI
IPC: B62B7/06
Filed: 2000-09-27
Abstract: A stroller includes two right and left front legs (2)
respectively having front wheels (1) mounted on the lower ends thereof,
two right and left rear legs (4) respectively not only having their
upper portions supported rotatably on the substantially central
portions of said front legs but also having rear wheels (3) mounted
on the rear ends thereof, two right and left hand-push frames (5)
respectively rotatable in their peripheral direction, each
hand-push frame including an upper portion curved in an inverted-L
shape to form a horizontal portion (5a) and a vertically extending lower
portion, said lower portion of said hand-push frame
can be slid in parallel to said front leg, a first open/close
link (6) formed in an X shape, a second open/close link (7)
and a connecting
portion (9) connecting said horizontal portions of said two hand-push
frames together through their joint portions (8) and cooperating with
said horizontal portions of said two hand-push frames in forming
a grip portion.
Patent EP-1112817-A2 (EP)
Inventor: DOELKER GERHARD
IPC: B25B11/00
Filed: 2000-10-27
Abstract: The machining process involves e.g. coating of furniture parts. There is a resting system on which the workpiece (3) is carried, including numerous resting bolts (8). Negative pressure is used to fix the bolts to the underside of the workpiece, so that either the workpiece with the bolts rises, or bolts not firmly attached in this way move down. In either case, the bolts held by suction remain in the upper position.
Patent EP-1113378-A2 (EP)
Inventor: CUNNINGHAM RICHARD L
IPC: G06Q30/00
Filed: 2000-12-12
Abstract: A distributed computer network is provided for delivering a newspapers or other articles
to a home, business, or other structure at which a customer resides. The system enables a
newspaper to be delivered one or more days a week, and enables a different newspaper to
be delivered. The system uses a central server (20) linked to geographically distributed
control computers (22) which can transmit it individual delivery computers (23) used by
newspaper delivery boys or other contractors.
Patent EP-1100065-A2 (EP)
Inventor: MCKILLIP BARRON G
IPC: B65D25/20
Filed: 2000-11-10
Abstract: A wrap for a container having an exterior includes a transparent
laminar substrate. An ink design is placed on at least a portion of a surface of
the substrate to leave other portions of the surface uncovered by the design.
The substrate is then positioned and held against the exterior of the container
to visually integrate the exterior of the container with the design on the
substrate. For one method of manufacture, the substrate may be made of a
shrinkable polyvinylchloride and is first formed as a tube with a lumen. The
container is then inserted into the lumen of the substrate and the substrate is
made to contact and conform with the exterior of the container by heat
shrinking.
Patent EP-1115235-A2 (EP)
Inventor: BROADHURST DENZIL
IPC: H04L25/08
Filed: 2000-12-14
Abstract: Electrical apparatus comprising a number of components or
functions is connected to a control system by a ribbon cable. The
ribbon cable includes a first line, which carries a signal or data to
control the operation of a first component or function, and at
least a second line, which carries a signal or data to control the
operation of at least a second component or function. An
additional signal or data is injected along the first line from the
control system which has the effect of reducing the effect of
noise from the signal or data passing along the at least second
line, on the signal or data passing along the first line.
Patent EP-1113026-A2 (EP)
Inventor: TAKAOKI KAZUO
IPC: C08F110/06
Filed: 2000-12-21
Abstract: An electron-withdrawing group-containing metal compound (I) of an atom of
Groups III to XII or the lanthanide series of the Periodic Table of the Elements, a
catalyst component for addition polymerization composed of the compound (I), a
catalyst for addition polymerization obtained by contacting the compound (I) with a
specific compound (II) of a metal of Groups III to XIII or the lanthanide series and
optionally an organoaluminum compound (III), and a process for producing an
addition polymer using the catalyst.
Patent EP-1033444-A2 (EP)
Inventor: GATENFJORD GOERAN
IPC: E01F13/06
Filed: 2000-03-03
Abstract: A barrier device comprising a barrier (1), a driving
device (2) for moving the barrier, an operating
device (3) for operating the driving device, said operating
device having an input (4) for an input signal for
operating the barrier, and a barrier detecting device
(58) for detecting the lowered barrier. The driving
device comprises two drive means (5, 6) which can each
take different positions. The drive means are arranged
so that each of them can take a position in which the
barrier is lowered independently of the position of the
other drive means, and the detecting means are arranged
on each of the drive means for detecting the position of
the respective drive means. The operating device (3) operates
both drive means (5, 6) to lower the barrier (1)
when it receives a signal from the detecting means indicating
that the drive means during a predetermined period
of time have an impermissible combination of positions.
Patent EP-1185710-A2 (EP)
Inventor: SHIMASAKI CRAIG D
IPC: C12Q1/70
Filed: 2000-04-12
Abstract: A chemiluminescent system for detecting the presence of influenza virus in a biological fluid sample is provided. An influenza diagnostic kit is provided which includes (1) a sampling device for obtaining the biological fluid from a subject, (2) a chemiluminescent substrate material which, in the presence of influenza virus in the biological sample, will generate a chemiluminescent product that will produce detectable light, and (3) a means for detecting any generated light. A liquid sample containing the biological fluid, and preferably a diluent, are contacted with an absorbent material containing the chemiluminescent substrate material. The substrate responds to neuraminidase activity intrinsic to influenza A and influenza B virus particles, such that when the substrate is in contact with influenza virus, the substrate is cleaved to yield a chemiluminescent product that then decomposes to produce light which can then be detected. The chemiluminescent substrate materials include enzymatically triggerable 1,2-dioxetane derivatives of 4-alkoxy-N-acetylneuraminic acid and 4,7-dialkoxy-N-acetylneuraminic acid. The system is sufficiently simple that it can reliably be used by a layperson in a nonmedical setting. The biological fluid generally originates from the oral cavity, the pharyngeal cavity, or the nasopharyngeal cavity.
Patent EP-1194648-A2 (EP)
Title: Systeme absorbant simple
Inventor: GRAEF PETER A
IPC: D04H13/00
Filed: 2000-05-25
Abstract: La présente invention concerne un composite absorbant simple qui possède une pluralité de strates. Dans ce composite, les strates contiguës sont séparées par une zone de transition connectant intégralement les strates. Chaque strate comprend des fibres et un liant, et la zone de transition comprend des fibres issues des strates contiguës. Cette invention concerne aussi des procédés de fabrication de ce composite simple.
Patent EP-1198554-A2 (EP)
Inventor: KEENAN ELIZABETH ANN
IPC: B01D67/00
Filed: 2000-08-07
Abstract: Improved methods and devices for detecting microorganisms, such as yeast and bacteria in mixtures, are disclosed. Methods include passing a sample mixture thorough a filter device, which has been pretreated with detergent resuspending the filtrand from the filter membranes and detecting the presence of microorganisms in the filtrand.