baber/WOPTO huggingface dataset:
Patent AU-2019365238-A1 (AU)
Title: Conjugated chemical inducers of degradation and methods of use
Inventor: DRAGOVICH Peter
IPC: A61P35/00
Filed: 2019-10-24
Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.
Patent AU-2019377131-A1 (AU)
Title: Lipid nanoparticle formulations
Inventor: LAM KIEU MONG
IPC: B82Y5/00
Filed: 2019-11-08
Abstract: The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (b) a cationic lipid of formula CL1 or CL2, and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid to a patient (e.g. a human) or to a cell.
Patent AU-2019384781-A1 (AU)
Title: Agent for inhibiting iron uptake into cells
Inventor: ZHANG LILIN
IPC: A61K39/395
Filed: 2019-11-19
Abstract: The present invention addresses the problem of providing an inhibitor of cellular iron uptake targeting TfR, and an inhibitor of binding between human Tf and human TfR. According to the present invention, provided is an inhibitor of cellular iron uptake, said inhibitor comprising an antibody which recognizes the 629th to 633rd amino acids in human transferrin receptor.
Patent AU-2019390691-A1 (AU)
Title: Targeted enrichment by endonuclease protection
Inventor: WHITE STEFAN JOHN
IPC: C12Q1/6806
Filed: 2019-11-27
Abstract: The current invention pertains to a method for the enrichment of a target nucleic acid fragment from a nucleic acid sample, comprising the steps of cleaving the nucleic acid sample with a first and a second RNA guided or DNA guided endonuclease complex, preferably a first and a second gRNA-CAS complex, thereby generating the target nucleic acid fragment and at least one non-target nucleic acid fragment. The generated fragments are subsequently contacted with an exonuclease, wherein the exonuclease digests only the non-target nucleic acid fragments. The invention further pertains to the use of the enriched target nucleic acid fragments for preparing an adapter ligated target nucleic acid fragment and for sequencing the target nucleic acid fragment.
Patent AU-2019392626-A1 (AU)
Title: Inhalable compositions for use in the treatment of pulmonary diseases
Inventor: DENK OLIVER
IPC: A61K9/127
Filed: 2019-12-03
Abstract: The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (100), the nebulizer comprising: a) an aerosol generator (101) comprising: - a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and a vibratable membrane (110) having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 4.0 gm as measured with a 0.9 % (w/v) aqueous solution of sodium chloride; b) a chamber (105) for temporarily accommodating the aerosol generated by the aerosol generator (101), the chamber having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece (40) for delivering the aerosol supplied by the nebulizer (100) to the subject, the mouthpiece having an exhalation filter (30).
Patent AU-2019395424-A1 (AU)
Title: Compositions and methods for immunosuppression
Inventor: CHANDRAKER ANIL
IPC: C12N5/0783
Filed: 2019-12-12
Abstract: Provided herein is are regulatory T cells (Tregs) capable of specifically suppressing immune response against a donor alloantigen or an autoantigen, compositions thereof, and methods for producing the same. Optionally, the Tregs are used in a population including natural killer (NK) cells. Also described are related methods for using the Tregs or mixed population of Tregs and NK cells, including for promoting allograft acceptance in a transplant recipient and treating autoimmune disorders in a subject. The Tregs or mixed population of Treg and NK cells are derived from the subject's blood cells and can reduce or replace the use of broad-acting immunosuppressants.
Patent AU-2019436796-A1 (AU)
Title: Air-conditioning apparatus
Inventor: ISHIMURA SHOHEI
IPC: F24F11/41
Filed: 2019-03-25
Abstract: The purpose of the present invention is to provide an air-conditioning device capable of defrosting parallel heat exchangers while maintaining heating capacity even during heating-defrosting operation. This air-conditioning device comprises: a main circuit including a compressor, a flow path switching device, an indoor heat exchanger, a pressure reducing device, and a plurality of parallel heat exchangers connected in parallel to each other being connected by pipes; a bypass pipe; a flow rate adjustment device that is disposed in the bypass pipe and adjusts the flow rate of the refrigerant flowing in the bypass pipe; an evaporation pressure sensor that detects the evaporation pressure of the refrigerant; and a control device. Operation modes of the air-conditioning device includes a normal heating operation mode and a heating-defrosting operation mode. When an operation related to the normal heating operation mode is switched to an operation related to the heating-defrosting operation mode, the control device adjusts the opening degree of the flow rate adjustment device on the basis of the evaporation pressure of the parallel heat exchangers serving as an evaporator and the drive frequency of the compressor.
Patent WO-2020181320-A1 (WO)
Inventor: HORSFIELD BRENDAN
IPC: G01R23/16
Filed: 2020-02-24
Abstract: A system for testing an antenna under test (AUT), and a system and method of locating a passive intermodulation (PIM) fault in an AUT is provided. The AUT comprises an input port and a plurality of branches, each branch ending in at least one radiating element. The method comprises: applying a plurality of RF stimulus signals to the input port of the AUT; receiving, by a fixed array of over-the-air probes, Forward PIM signals emitted from at least one of the plurality of radiating elements; measuring, by a PIM analyser, one or more characteristics of the Forward PIM signals received by the fixed array of over-the-air probes; and analyzing the one or more characteristics of the Forward PIM signals to locate the PIM fault in the AUT.
Patent WO-2020198803-A1 (WO)
Title: Assembly and method for attaching a heliostat to a foundation
Inventor: LESLIE BRUCE ALEXANDER
IPC: F24S25/634
Filed: 2020-04-03
Abstract: This disclosure relates to an assembly and method for attaching a heliostat to a foundation in a tower-based solar thermal CSP installation. A heliostat securing assembly for securing a heliostat to a tubular foundation post comprises an insert locatable within an upper opening in the foundation post, the insert defining an aperture for receiving a support shaft of the heliostat. A clamp arrangement, for locating the insert in the upper opening in the foundation post, has at least one inner or outer bearing surface configured to bear against at least one corresponding outer or inner bearing surface of the insert. One or more urging connectors, for connecting the insert and the clamp arrangement, is operable to urge at least one of the insert and the clamp arrangement toward the other in an axial direction of the foundation post. At least one of the at least one outer or inner bearing surface and the at least one corresponding inner or outer bearing surface is configured to transform at least a portion of relative axial movement between the insert and the clamp into relative transverse movement such that, when the insert is located in the upper opening in the foundation post, operation of the urging connector(s) urges at least one of the insert and clamp arrangement in the transverse direction to clamp the securing assembly between the support shaft and foundation post and thereby secure the heliostat to the foundation post.
Patent WO-2020206505-A1 (WO)
Title: Shielding device for electrical wiring, cabling, pipes and the like
Inventor: DI FABIO ANTONIO
IPC: F16L57/06
Filed: 2020-04-13
Abstract: A shielding device (400) comprises: a shielding member (405), configured to shield from mechanical damage one or more electrical wires, cables or pipes (115) that are traversing a joist or beam (110); and a retaining member (410), fixedly coupled to the shielding member, and configured to retain the shielding member in position adjacent to the joist or beam, to thereby shield the one or more electrical wires, cables or pipes.
Patent WO-2021119733-A1 (WO)
Inventor: SHARP DAVID JAMES
IPC: H02S10/40
Filed: 2020-12-15
Abstract: A mobile solar panel unit (10) comprising: (a) a transport device (10) having a load zone (20) having a cross sectional area; and (b) an assembly (30) of a plurality of inter-connected solar collector panels (40,42,44) for providing, in use, power to an associated equipment item (70); wherein adjacent panels (40,42; 42,44) in said assembly (30) of solar collector panels (40,42,44) are inter-connected by rotatable connection means (50,50a) for rotating panels (40,44) allowing both storage of said assembly (30) of inter-connected solar collector panels (40,42;42,44) in said load zone (20) and deployment of said assembly (30) of inter-connected solar collector panels (40,42,44) to a collection position to generate power when exposed to sunlight.
Patent AU-2020200604-A1 (AU)
Title: Power flow control subsystem having multiple configurations
Inventor: PARKS JOHN
IPC: H02J11/00
Filed: 2020-01-29
Abstract: OF THE DISCLOSURE 
A power flow control subsystem having multiple configurations is described. The 
subsystem is three-way configurable: as a transportable configuration, as a deployable 
configuration, and as a transmission line configuration. The transportable configuration 
includes a collection of impedance injection modules and at least one bypass module carried 
on a wheeled vehicle such as a trailer. The deployable configuration is an assembly of the 
collection of impedance injection modules and at least one bypass module, operable to 
perform power flow operations. The transmission line configuration includes connection of a 
deployable configuration to a phase of a high voltage transmission line for performing power 
flow control. The deployable configuration may be open or closed frame. The deployable 
configurations may be mounted on one or more wheeled vehicles in a mobile subsystem, or 
semi-permanently mounted at a ground site.  
13
1/10 
10 
15 
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123 
FIG. 1
Patent AU-2020201705-A1 (AU)
Title: Stent cannulation guiding device for bifurcated stent and method of use
Inventor: FLEMING JAMES A
IPC: A61F2/00
Filed: 2020-03-06
Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises a pre-loaded second wire positioned within the contra-lateral leg which facilitates access to said leg in accordance with the present invention. O6/0/20 I12171 11 1 1CM ttre,\ IP101110 AT I2 22a 21a 22b 21b 20 21
Patent AU-2020202439-A1 (AU)
Title: A wire rope or cable safety barrier system typically for roadside use
Inventor: COLQUHOUN TERRY
IPC: E01F15/06
Filed: 2020-04-08
Abstract: The present invention provides a wire rope barrier assembly 10 having a post 12 with slot 20 at 
its upper end forming a space located between two upper post portions 16, 18; a cable or wire 
rope 32 located at the lower end of said space 20 and a cap 24 positioned on the upper end of 
said post 12 which receives said two upper post portions 16, 18, said cap 24 including a slot 26 
extending downwardly from its upper surface to provide a space into which is received an upper 
wire rope or cable 36.
Patent AU-2020203491-A1 (AU)
Title: Source code translation
Inventor: BEIT-AHARON JONATHAN
IPC: G06F9/44
Filed: 2020-05-27
Abstract: Abstract A method involving receiving a group of software components, the group of software components comprising code units specified in one or more text-based programming languages, the group of software components together defining a first data processing activity representing a transformation of input data comprising a plurality of data records to output data. The code units are processed to form respective dataflow graph representations in a dataflow graph programming language and the dataflow graph representations are combined to form a composite dataflow graph in the dataflow graph programming language. The composite dataflow graph defines a second data processing activity representing an equivalent transformation of the input data to the output data, and including at least one type or parallelism from a group consisting of component, data, and pipeline parallelism, the at least one type of parallelism not defined in the first data processing activity.
Patent AU-2020210258-A1 (AU)
Title: Anti-PD-L1 antibody and IL-7 fusions
Inventor: FANG LEI
IPC: A61P31/00
Filed: 2020-07-30
Abstract: Provided are fusion molecule having a PD-Li inhibitor fused to a human IL-7 protein 
or fragment thereof through a peptide linker. The disclosed fusion molecules exhibited 
synergistic anti-tumor effects.
Patent AU-2020231593-A1 (AU)
Title: A security sheet
Inventor: BOBAT SHIREEN
IPC: B42D25/36
Filed: 2020-02-19
Abstract: The present disclosure is directed towards a security sheet (11) comprising a data sheet (15) and an attachment layer (17) for attaching the data sheet (15) in a security document (10). The data sheet (15) is attached to the attachment layer (17) at an inner edge (22) having a nonlinear inner edge (22) profile. The term "nonlinear" means that an edge profile is not straight and comprises at least one curve and/or at least two straight lines at a non-straight angle to one another. The present disclosure further provides a security document (10) comprising such a security sheet (11) and a method of manufacturing such a security sheet (11) or document (10).
Patent AU-2020244450-A1 (AU)
Title: Touch sensitive audio-visual input/output device and method
Inventor: KLEIN ALEX
IPC: H04R1/02
Filed: 2020-09-29
Abstract: TOUCH SENSITIVE AUDIO-VISUAL INPUT/OUTPUT DEVICE AND 
METHOD 
5 
A touch sensitive audio-visual input/output device is provided comprising an internal 
core having a controller associated with at least one processor and a memory store, a 
light emitter associated with the controller, at least one audio output component 
associated with the controller, at least one actuator provided relative to the housing 
10 and associated with the controller and configured to transmit touch inputs to the 
controller to control operation of the device. The device includes a flexible outer 
casing for at least partially enclosing the internal core and at least one audio input 
component configured to capture audio with the captured audio being available for 
storage, playback and/or manipulation by the device.  
15
1/9 
40 
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20 
Figure 1 
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Figure 2
Patent AU-2020266341-A1 (AU)
Title: Self-supervised training of a depth estimation model using depth hints
Inventor: WATSON JAMES
IPC: G06N20/00
Filed: 2020-05-02
Abstract: A method for training a depth estimation model with depth hints is disclosed. For each image pair: for a first image, a depth prediction is determined by the depth estimation model and a depth hint is obtained; the second image is projected onto the first image once to generate a synthetic frame based on the depth prediction and again to generate a hinted synthetic frame based on the depth hint; a primary loss is calculated with the synthetic frame; a hinted loss is calculated with the hinted synthetic frame; and an overall loss is calculated for the image pair based on a per-pixel determination, wherein if the hinted loss is smaller than the primary loss, then the overall loss includes the primary loss and a supervised depth loss between depth prediction and depth hint. The depth estimation model is trained by minimizing the overall losses for the image pairs.
Patent AU-2020267283-A1 (AU)
Title: Nanos knock-out that ablates germline cells
Inventor: OATLEY JOHN MICHAEL
IPC: A01K67/027
Filed: 2020-11-13
Abstract: The present invention provides livestock animals and methods to create recipient 
animals for spermatogonial stem cell transplantation through modulation of the NANOS gene.  
In one embodiment genome editing issued to create animals with insertions or deletions 
(indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males 
lack functional germ cells yet retain functional somatic cells, and females are fertile. These 
males can then be transplanted with donor spermatogonial stem cells and used for breeding.
Patent AU-2020270875-A1 (AU)
Title: A single-column semi-submersible platform
Inventor: VATNE PER ANDREAS
IPC: B63B35/44
Filed: 2020-04-07
Abstract: A single-column semi-submersible platform (1) for fixed anchoring in deep water.The semi-submersible platform (1) comprises a lower solid ballast module (6), amiddle seawater ballast module (7) and a top buoyancy module (8). The three modules (6,7,8) are arranged telescopically in an axial direction and can be controlled relative to each other in the axial direction such that the semi-submersible platform (1) may float vertically and steadily in a body of water. Draught for the seawater ballast module (7) and buoyancy module (8) is provided by seawater ballasting. The axial position of the solid ballast module (6) relative to the seawater ballast module (7) is controlled by seawater being pumped in and out of a closed annulus (46) formed between the solid ballast module (6) and the seawater ballast module (7). (Figure 1 to be published with the abstract)
Patent AU-2020275304-A1 (AU)
Title: Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions
Inventor: CUNY GREGORY
IPC: A61K31/519
Filed: 2020-05-14
Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions.
Patent AU-2020276303-A1 (AU)
Title: System and method for making an ice straw
Inventor: SURGENT THOMAS
IPC: A47G21/18
Filed: 2020-05-16
Abstract: A system and method for making degradable drinking straws made of ice (or other frozen liquid(s)). The system may comprise one or more tubes configured to extend into a reservoir. The tubes may each be in fluid communication with a connecting bar, wherein fluid (e.g., a liquid and/or a gas) within the connecting bar may be directed into the tubes. The system may comprise a source of cold fluid and a source of hot fluid in fluid communication with the connecting bar. The degradable straw may comprise a wall (or thickness) made of ice with a hollow, cavity, and/or void space through the straw. The degradable straw may serve to cool the drink (as any other piece of ice within the drinking liquid) via placement in a drink and/or via the drink passing through the void space into a user's mouth.
Patent AU-2020278589-A1 (AU)
Title: System and methods for estimation of blood flow using response surface and reduced order modeling
Inventor: SANKARAN SETHURAMAN
IPC: G16H50/50
Filed: 2020-05-15
Abstract: Systems and methods are disclosed for blood flow simulation. For example, a method may include performing a plurality of blood flow simulations using a first model of vascular blood flow, each of the plurality of blood flow simulations simulating blood flow in a vasculature of a patient or a geometry based on the vasculature of the patient; based on results of the plurality of blood flow simulations, generating a response surface mapping one or more first parameters of the first model to one or more second parameters of a reduced order model of vascular blood; determining values for the one or more parameters of the reduced order model mapped, by the response surface, from parameter values representing a modified state of the vasculature; and performing simulation using the reduced order model parameterized by the determined values, to determine a blood flow characteristic of the modified state of the vasculature.
Patent AU-2020383800-A1 (AU)
Title: Two-layer multi-strand cable having a sheathed inner layer and improved penetrability
Inventor: GIANETTI ALEXANDRE
IPC: D07B1/16
Filed: 2020-11-05
Abstract: The invention relates to a two-layer multi-strand cable (50) comprising: - an inner layer (CI) that has two layers (C1, C3) and consists of K≥1 inner strand(s) (TI), and an outer layer (CE) consisting of L>1 outer strands (TE) that have two plies (C1', C3 ') and are wound around the inner layer (CI) at a helix radius R2. The outer plies (C3, C3') of each inner and outer strand (TI, TE) are desaturated. The cable (50) is obtained by a method involving a step of manufacturing the sheathed inner layer (CIG) in which the inner layer (CI) is surrounded by an elastomer composition having a thickness G and then by an outer layer (CE), G being such that R2/Rt ranges from 1.02 to 1.25, with Rt being the helix radius of the theoretical outer layer (CET) obtained when the inner layer (CI) is in direct contact with the theoretical outer layer (CET), and a step (400) to bring the outer layer (CE) of the cable closer to the circle circumscribing the inner layer (CI) of the cable so that the ratio R2/Rt ranges from 1.00 to 1.10.
Patent AU-2020388059-A1 (AU)
Title: Polypeptide inhibitors of neutrophil elastase activity and uses thereof
Inventor: LAWRENCE DANIEL
IPC: C12N9/66
Filed: 2020-11-19
Abstract: The invention features polypeptides that include variants of plasminogen activator inhibitor 1 (PAI-1) having a reduced ability to bind with vitronectin, having a reduced ability to interact with the PAI-1 clearance receptor LDL receptor-related protein 1 (LRP1), and having the ability to efficiently inhibit neutrophil elastase in the presence of neutrophil extracellular traps (NETs). In some embodiments, a polypeptide of the invention includes PAI-1 variants optionally fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions characterized with aberrant neutrophil elastase activity (e.g., Idiopathic Pulmonary Fibrosis).
Patent AU-2020388848-A1 (AU)
Title: Use of FAK inhibitor in preparation of drug for treating tumors having NRAS mutation
Inventor: WANG ZAIQI
IPC: A61K31/506
Filed: 2020-11-17
Abstract: A use of a FAK inhibitor in the preparation of a drug for preventing and/or treating tumors having an NRAS mutation. A method for treating tumors that have experienced an NRAS mutation, which comprises administering an effective dose of a FAK inhibitor to an individual. A FAK inhibitor for treating tumors having an NRAS mutation. The FAK inhibitor is BI853520, defactinib, GSK2256098, PF-00562271, VS-4718 or a pharmaceutically acceptable salt thereof.