Patent SG-11201808242U-A (SG)
Title: Methods for inhibiting angiogenesis in a subject in need thereof
Inventor: DEMOPULOS GREGORY
IPC: A61K39/395
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER (19) World Intellectual Property -, Organization International Bureau 0.. .... .. (43) International Publication Date ...... ... 5 October 2017 (05.10.2017) IN I PO I P CT THE PATENT COOPERATION TREATY (PCT) MD 1101111 0 HEIN MEM 01E010 111110010111 11101101111101111 MI (10) International Publication Number WO 2017/173290 Al (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) (72) (71) International Patent Classification: A61K 39/395 (2006.01) A61P 27/02 (2006.01) A61P 7/00 (2006.01) C07K 16/40 (2006.01) International Application Number: (74) PCT/US2017/025411 International Filing Date: (81) 31 March 2017 (31.03.2017) English English Priority Data: 62/315,857 31 March 2016 (31.03.2016) US Applicants: OMEROS CORPORATION [US/US]; 201 Elliott Avenue West, Seattle, WA 98119 (US). UNIVER- SITY OF LEICESTER [GB/GB]; University Road, Leicester, Leicestershire LE1 7RF (GB). Inventors; and (84) Applicants : DEMOPULOS, Gregory, A. [US/US]; 4845 Forest Avenue SE, Mercer Island, WA 98040 (US). SCHWAEBLE, Hans-Wilhelm [DE/GB]; 36 The Green, Mountsorrel, Leicestershir LE12 7AF (GB). DUDLER, ZA, ZM, ZW. Thomas [CH/US]; 13410 NE 36th Street, Bellevue, WA 98005 (US). TJOELKER, Larry [US/US]; 11731 North- east 145th Street, Kirkland, WA 98034 (US). Agent: KELBON, Marcia; Omeros Corporation, 201 Elli- ott Avenue West, Seattle, WA 98119 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [Continued on next page] = = — Title: METHODS FOR INHIBITING ANGIOGENESIS o 00 (54) IN A SUBJECT IN NEED THEREOF (57) : In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian sub- ject suffering from, or at risk for developing, an an- giogenesis-dependent disease or condition, compris- ing administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit an- giogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof. = = ewmw , KOLIIS te:,! COMPaM to vehic;e: * ;),,c,:i...i. ixer,001. — = = - 4t. ea** = — = = 0 0 0 0 0 10 = — = *a* • • = — = = :Fig.10. 11 © C:r ei M IN ,-1 IN ,—, © ei O WO 2017/173290 Al MUNRO DOI 01011MMEMOMMEINEHMON111EHOIMIE DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, — as to the applicant's entitlement to claim the priority of LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, the earlier application (Rule 4.17(iii)) GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: Declarations under Rule 4.17: — with international search report (Art. 21(3)) — as to applicant's entitlement to apply for and be granted — a patent (Rule 4.17(ii)) with sequence listing part of description (Rule 5.2(a))