baber/WOPTO huggingface dataset:
Patent CA-2339889-C (CA)
Title: Identification of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests
Inventor: FRISCH CHRISTIAN
IPC: C07K16/28
Filed: 2000-06-30
Granted: 2012-01-31
Abstract: The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion proteins which are forming inclusion bodies on expression in host cells. The inclusion bodies are used to generate binding partners which bind specifically to said (poly)peptides. The specific binding partners, in particular immunoglobulins or fragments thereof, are useful for analysis and functional characterisation of proteins encoded by nucleic acid sequences comprising the corresponding genomic DNA fragments or ESTs. The invention further relates to nucleic acid molecules, vectors and host cells to be used in the methods of the present invention. The invention further relates to the use of fusion proteins comprising the first N-terminal domain of the geneIII protein of filamentous phage as fusion partner for the expression of a (poly)peptide/protein fused to said fusion partner, and to methods for the expression of (poly)peptide/proteins.
Patent CA-2341941-C (CA)
Inventor: KIYOKAWA MASAHIRO
IPC: G01R31/3161
Filed: 2001-03-21
Granted: 2006-07-04
Abstract: A method is provided for measuring harmonic load-pull for frequency multiplication to obtain a load impedance and a source impedance for which frequency multiplication performance of a frequency multiplication device is optimized.  A fundamental frequency signal is supplied to a frequency multiplication device under test from a source measurement system that includes a source mechanical tuner for adjusting a fundamental source impedance of an input signal. A load impedance frequency is obtained at which multiplication performance of the frequency multiplication device is optimum from a load measurement system that includes a load mechanical tuner for adjusting a load impedance of a target even-order multiplied signal among harmonics included in signal output of the frequency multiplication device. Fundamental load impedance and even-harmonic load impedance are independently controlled by means of a mechanical tuner on the load side that includes a control device which functions as an open-ended stub that is one-quarter wavelength long at the fundamental frequency, and at its position satisfies a short-circuit condition with respect to the fundamental frequency signal. The control device controls a fundamental load impedance that in accordance with a position at which the stub is set determines an electrical angle from an output section of a device under test to a short-circuit point. The fundamental source impedance and even-harmonic source impedance are independently controlled by means of a source mechanical tuner that includes a control device that functions as a short-circuit stub that is a quarter wavelength long at the fundamental frequency, which satisfies a short-circuit condition with respect to even-order harmonics that include the second harmonic signal for controlling an even-harmonic source impedance that in accordance with a position at which the stub is set determines an electrical angle from an input section of a device under test to the short-circuit point.
Patent CA-2345209-C (CA)
Title: Modulation antisens de l'expression de l'integrine alpha 4
Inventor: BENNETT C FRANK
IPC: A61P25/28
Filed: 1999-08-19
Granted: 2014-04-22
Abstract: L'invention concerne des compositions et des procédés pour la modulation de l'expression de l'intégrine .alpha.4. Des composés antisens, notamment des oligonucléotides antisens, dirigés sur des acides nucléiques codant l'intégrine .alpha.4 sont préférés. Des procédés d'utilisation de ces composés, pour la modulation de l'expression de l'intégrine .alpha.4 et pour le traitement de maladies associées à l'expression de l'intégrine .alpha.4, sont également décrits.
Patent CA-2345799-C (CA)
Title: Process for reducing mineralization of tissue used in transplantation
Inventor: TORRIANNI MARK W
IPC: A61F2/24
Filed: 1999-09-30
Granted: 2010-01-05
Abstract: The present invention provides a method for reducing the level of mineralization of tissue in a tissue--derived implantable medical device. Preferably, the method reduces the level of bioprosthetic valvular mineralization, and in particular bioprosthetic valvular pathologic calcification. A method of making a tissue-derived implantable medical device includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device. The tissue--derived implantable medical device treated by a method of the invention exhibits improved anti-mineralization properties, and/or longer term resistance to in vivo pathologic calcification than provided by other methods of reducing and/or preventing mineralization.
Patent CA-2347037-C (CA)
Title: Instrument valve manifolds for use with pressure transmitters
Inventor: HUTTON PETER B
IPC: G01L19/00
Filed: 1999-10-19
Granted: 2009-02-17
Abstract: An instrument valve manifold (10, 210) interfaces between a flowline control manifold CM and one or more pressure transmitter units (T1, T2). The instrument valve manifold includes a monolithic body (32, 232) that defines a mating surface (34, 234) having a low pressure port (52, 252) and a high pressure port (54, 254), a low pressure plenum (58, 258) and a high pressure plenum (60, 260), and at least one equalizing valve pocket (96, 296) for receiving an equalizing valve (100, 300). Fluid passageways in the body (32, 232) extend from the low pressure input port to the low pressure plenum and from the high pressure input port to the high pressure plenum. The instrument valve manifold reduces the size and weight of components connected to the control manifold, reduces the moment arm of the combined weight of the instrument valve manifold and the transmitter on the control manifold, and distributes the weight substantially equally about the plane of symmetry (30) of the control manifold.
Patent CA-2347905-C (CA)
Inventor: IVERSEN PATRICK L
IPC: A61K31/65
Filed: 1999-10-22
Granted: 2009-12-15
Abstract: L'invention concerne des oligonucléotides, utiles pour traiter une pathologie induite par p53, telle que des désordres cellulaires prolifératifs, par exemple le cancer, ou un état hypoxique induit par un accident ischémique cérébral, tel qu'un ictus. Ces agents sont, de préférence, de la classe connue des oligonucléotides du type stériquement encombré, notamment des morpholino oligonucléotides, des acides nucléiques peptidiques, des oligonucléotides modifiés par 2'-O-allyle ou par 2'-O-alkyle, ou des N3' } P5' phosphoramidate oligonucléotides.
Patent CA-2354967-C (CA)
Inventor: FEIGE REINHARD
IPC: C04B22/04
Filed: 2001-08-13
Granted: 2006-04-25
Abstract: The invention relates to a porosifying, solidification-accelerating additive for binding agent building materials, consisting of Al2O3     50 - 90 %      MgO              4 - 20 %      SiO2           0.5 - 15 %  AlN            0.1 - 5 %      Fe2O3          0.1 - 5 %      CaO            0.1 - 5 %      F              0.1 - 5 %      Na2O           0.1 - 5 %      K2O       0.1 - 2 % as well as in the form of metallic particles A1    0.1 - 10 %      Si               0.1 - 3 %      Fe               0.1 - 3 % balance in total up to 5 % annealing losses       0.1 - 15 % and of mineral main constituents in the form of corumdum (.alpha.-Al2O3) and spinel (MgO × Al2O3) , wherein the metallic aluminium particles are enveloped by mineral transition modifications from aluminium hydroxide (Al2O3 × 3H2O) to .alpha.-aluminium oxide, wherein the powder comprises a particle size of at least 90% smaller than 500 µm and wherein the BET surface of the powder amounts to at least 10 m2/g. Furthermore, the invention relates to a process of producing a porosifying, solidification-accelerating additive for a binding agent building material by thermally treating the powder in a flue gas flow down to a residual moisture of 2 % maximum by shock drying at flue gas temperatures of 400 to 500 °C in a drying time of less than 10 seconds, and by thermally activating the powder by partially calcinating same within a temperature range of 400 to 1,000 °C, wherein the holding time is calculated in such a way that there is obtained a BET surface of the activated powder of at least 10 m2/g, and wherein the metallic aluminium particles are enveloped by mineral transition modifications from aluminium hydroxide (Al2O3 × 3H2) to .alpha.-aluminium oxide.
Patent CA-2357223-C (CA)
Title: Apparatus and method for header decompression
Inventor: MIYAZAKI AKIHIRO
IPC: H04L69/40
Filed: 2001-09-10
Granted: 2006-01-17
Abstract: In a header decompression apparatus 709, a header decompressor 703 refers to reference information stored in a reference information manager 707 to decompress a compressed header of a packet received by a packet receiver 704. An error detector 702 detects a CRC error in the packet with its header decompressed by the packet receiver 704, and outputs only a correct packet. A successive error counter 705 counts the number of successive errors detected by the error detector 702. A successive decompression success counter 706 counts the number of decompression successes that successively appear. By referring to these counted numbers, an update request unit 708 transmits an update request to a transmitting side as required. A reference information manager 707 manages the reference information for header decompression. With this structure, the header decompression apparatus can request update of the reference information based on the state of the error.
Patent CA-2359203-C (CA)
Inventor: GIBSON RICHARD D
IPC: F02M21/02
Filed: 2001-10-17
Granted: 2005-05-10
Abstract: A gas fuel system for a bi-fuel engine includes an injector block assembly that supports gas fuel injectors between an injector block and an inlet header. The block assembly may be mounted beside or behind the engine remote from the engine intake ports where gasoline fuel or gaseous fuel (gas) may be injected for powering the engine. The block assembly connects the injectors through individual distribution lines with separate port openings of an adapter plate mounted between the air intake manifold and the engine intake ports to provide for injection of gas to the intake ports from the remote location. Mounting of the injectors in the remote block assembly, which feeds the adapter, avoids changes to a developed gasoline fuel system in the engine, thus reducing development and production costs. The block assembly may also be modified to use other available gas injectors without affecting the conventional engine components.
Patent CA-2363458-C (CA)
Inventor: NAKAGAWA KOJI
IPC: A23L2/38
Filed: 1999-12-17
Granted: 2008-08-12
Abstract: A process for producing a drink by desalting seawater to separate it into water and a concentrate sufficiently containing essential minerals such as magnesium, calcium and iron and vitamins, etc., and adding to the water either one of the concentrate itself or essential mineral components such as water-soluble magnesium, calcium, iron, etc.  separately obtained from a seawater concentrate; and health-promoting drinks obtained by the method.
Patent CA-2378457-C (CA)
Inventor: WILSON REBECCA ANNE
IPC: H01S5/183
Filed: 2000-07-10
Granted: 2008-11-18
Abstract: L'invention concerne un laser à cavité verticale et à émission par la surface (VCSEL) comportant une structure de réseau unidimensionnelle, telle qu'un réseau de diffraction unidimensionnel conçu pour agir comme un guide d'onde situé, de préférence, à une surface terminale du VCSEL de manière à refléter sélectivement davantage d'une première polarisation de lumière dans une cavité du VCSEL que d'une seconde polarisation de lumière orthogonale. Le VCSEL comprend, de préférence, un miroir de Bragg supérieur, une zone de gain, et un miroir de Bragg inférieur, et la structure réseau unidimensionnelle située sur une couche supérieure du miroir de Bragg supérieur, ladite couche ayant une épaisseur telle, que la lumière reflétée d'une polarisation interfère de façon constructive avec la lumière de la polarisation reflétée par le miroir de Bragg supérieur. Le VCSEL va ensuite produire un effet laser sur la polarisation qui est reflétée de manière plus prédominante par la structure réseau. En outre, le miroir de Bragg supérieur a une épaisseur telle que la lumière reflétée d'une polarisation interfère de manière destructive avec la lumière de cette polarisation reflétée par le miroir de Bragg supérieur. Le VCSEL va ensuite produire un effet laser sur la polarisation qui n'est pas reflétée de manière prédominante par la structure réseau.
Patent CA-2381664-C (CA)
Title: Steam tube structure of gas turbine
Inventor: TANIOKA TADATERU
IPC: F01D25/12
Filed: 2002-04-09
Granted: 2005-08-23
Abstract: A vapor tube structure in a gas turbine comprises first connecting tubes fixed to a casing, second connecting tubes fixed to a blade ring, a recovery ring and a cooling recovery ring, a bellows tube of the flexible structure, springs, a tube and a piston rings provided between the first connecting tubes and the second connecting tubes. As a result, it is possible to absorb and follow the thermal expansion/contraction difference and prevent leaking of vapor.
Patent CA-2387163-C (CA)
Inventor: LAPIDUS ALBERT L VOVICH
IPC: C10G9/36
Filed: 2000-10-17
Granted: 2009-12-15
Abstract: A process for the preparation of a catalyst for carbon monoxide hydrogenation particularly Fischer-Tropsch reactions;  the catalyst compositions, use of the catalyst compositions for conducting such reactions. The process for producing the catalyst comprises impregnating a powder, or particulate refractory inorganic oxide solids, preferably silica, with a) a soluble compound or salt of a catalytic metal of the Iron Group, preferably cobalt, and b) a soluble compound of a Group VIII noble metal, preferably platinum, suitably by sequential contact of the solids with a solution of (a) and a solution of (b), by sequential contact of the solids with a solution of (b) and a solution of (a), or by contact with a solution which contains both (a) and (b). The metals impregnated solids, or particulate solids precursor material, after impregnation with the Group VIII  noble metal, is washed with a hydrocarbyl ammonium hydroxide or ammonium hydroxide solution, the material shaped, dried and calcined, and the metals components thereof thereafter reduced. The catalyst thus formed, quite surprisingly, is more active and selective in conducting a carbon monoxide hydrogenation reaction to produce hydrocarbon waxes, with lower gas make.
Patent CA-2395623-C (CA)
Title: Inulin products with improved nutritional properties
Inventor: FRIPPIAT ANNE
IPC: A23L29/244
Filed: 2001-02-14
Granted: 2006-08-01
Abstract: The invention relates to novel inulin products and compositions thereof, to their manufacture, to their use for modifying and modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans, mammals or other vertebrates, to their use for providing improved inulin-associated nutritional effects/benefits, as well as to their use for the manufacture of consumer products and compositions for providing said effects/benefits in healthy, disfunctioned and diseased humans, mammals and other vertebrates. The novel inulin products consist of a particular mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component. The nutritional effects/benefits include dietary fibre effects, improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and/or for treating osteoporosis in humans, particularly in post-menopausal women and elderly people.
Patent CA-2395771-C (CA)
Inventor: PINCKARD MITCHELL D
IPC: E21B44/00
Filed: 2001-04-16
Granted: 2007-01-23
Abstract: A method of and system for optimizing bit rate of penetration while drilling substantially continuously determine an optimum control variable value necessary to achieve an optimum bit rate of penetration based upon measured conditions and maintains control variable value at the optimum control variable value. As measured conditions change while drilling, the method updates the determination of optimum control variable value.
Patent CA-2401852-C (CA)
Inventor: CULLY DORIS F
IPC: C12N15/85
Filed: 2001-02-26
Granted: 2011-05-10
Abstract: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding Drosophila ligand-gated ion channel proteins, substantially purified forms of associated Drosophila ligand-gated ion channel proteins and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Drosophila melanogaster ligand-gated ion channel proteins, which will be useful as insecticides.
Patent CA-2407241-C (CA)
Title: Self-inking stamp
Inventor: KONECZNY HARALD
IPC: B41K1/40
Filed: 2001-04-18
Granted: 2009-01-20
Abstract: The invention relates to a self-inking stamp with overhead inking, with a lower component for placement on the surface to be stamped, with a swivel mechanism for a print platen support arranged in the lower component for reciprocal movement by simultaneous swivelling between a stamp pad and a support frame, and with an actuator upper component mounted for slideable movement against the bias of a spring relative to the lower component, the upper component being mounted over the lower component and connected by its lateral parts to the lower component by a print platen support swivel axle guided in elongated openings of the lower component.
Patent CA-2407758-C (CA)
Inventor: NIZAMUDDIN NASH
IPC: A63C3/00
Filed: 2002-10-11
Granted: 2010-12-07
Abstract: The exercise apparatus disclosed herein is to simulate skating or roller blading movement in a user, and thereby exercise and tone the muscles used for skating. The apparatus includes a pair of sleds or shuttles which include a pedal adapted to support the foot of a user standing thereon. The shuttles are movable along a respective guide assembly consisting of one or more rails which curve away from each other extending from proximate forwardmost ends, outwardly and rearwardly. The rail assemblies are provided in a substantially mirror arrangement and curve downwardly from their respective forwardmost ends to a lowermost distal portion. A guide member is provided to assist in positioning and maintaining the shuttles in sliding movement along each guide assembly, whereby the reciprocal sliding movement of the shuttles along an associated guide assembly acts to guide the feet of the user in skating or roller blade movement.
Patent CA-2413567-C (CA)
Title: Separation method and analysis method of hydrogen ion and ion chromatography apparatus
Inventor: FUGETSU BUNSHI
IPC: B01D15/36
Filed: 2001-06-20
Granted: 2006-05-16
Abstract: A method for the separation of hydrogen ion, characterized in that a substance having a conjugate base (A-) of an acid (HA) as a functional group is used as a stationary phase, and an electrolyte containing a cation having a larger ion exchanging force than that of hydrogen ion is used as an eluent. The method allows the selective separation of hydrogen ion and the quantitative analysis thereof with high precision.
Patent CA-2414827-C (CA)
Title: Break-away tire
Inventor: DURUISSEAU NOEL GILLES JOSEPH
IPC: A01K15/02
Filed: 2003-01-06
Granted: 2006-05-30
Abstract: A Break-Away tire apparatus for the sport of dog agility comprising the combination of two semi-circular arcs joined together by an arrangement of magnets so that the end result appears to be a solid or complete tire. There is an upper half and a bottom half each being symmetrical in shape. Each half, having an arrangement of magnets that create the means to mechanically fasten the two halves together. The magnets are centered and orientated in the transverse cross-section of the tire at each endpoint of the arcs so that the maximum magnetic force or axis is orientated vertically. The magnets not only act as a means to fasten the two halves together but also act as the weakest point in the structural integrity of the tire. Thus allowing upper and lower arc portions to disconnect when sufficient impact force is applied to the apparatus.
Patent CA-2415494-C (CA)
Inventor: GARIMELLA VISWANADHAM
IPC: G01N33/543
Filed: 2001-07-11
Granted: 2007-09-18
Abstract: L'invention concerne un procédé d'amplification d'un signal de détection consistant à accroître ou favoriser le dépôt d'argent additionnel dans des systèmes de détection par dosage, dans lesquels la formation d'une tache d'argent sert en tant que marqueur de la présence d'une molécule cible, notamment des polymères biologiques (par exemple des protéines et des acides nucléiques), et des petites molécules.
Patent CA-2422708-C (CA)
Inventor: LANGE JOSEPHUS H M
IPC: A61P25/24
Filed: 2002-03-18
Granted: 2010-10-26
Abstract: La présente invention concerne un groupe de nouveaux dérivés de 4,5-dihydro-1H-pyrazole ayant une configuration S dans la position 4 de leur cycle 4,5-dihydro pyrazole, lesdits dérivés représentant de puissants antagonistes du récepteur CB¿1? du cannabis. Ces composés se caractérisent par la formule générale (I) dans laquelle: R and R¿1? sont identiques ou différents et représentent 3-pyridyle ou 4-pyridyle ou phényle qui peuvent être substitués avec halogène ou méthoxy; R¿2? et R¿3? sont identiques ou différents et représentent hydrogène, alkyle (1-3 C) ou diméthylamino; R¿4? représente phényle qui peut être substitué avec 1 ou 2 substituants choisis parmi le groupe comprenant les atomes d'halogène, trifluorométhyle, méthoxy et alkyle (1-3 C). Cette invention concerne également des tautomères, promédicaments et sels desdits dérivés. Ces énantiomères sont des antagonistes du récepteur CB¿1? du cannabis de puissance et sélectivité supérieures à celles des autres énantiomères.
Patent CA-2429439-C (CA)
Inventor: ASAHI HITOSHI
IPC: B23K9/23
Filed: 2003-05-23
Granted: 2008-10-07
Abstract: The present invention provides an ultra-high- strength steel pipe excellent in weldability on site and a method for producing the steel pipe by improving the reliability of the low temperature toughness of a steel to which elements to enhance hardenability are added for furthering high-strengthening and also improving toughness at a weld heat affected zone subjected to double or more layer welding and, in the method, the steel is made to consist of a structure composed of bainite and/or martensite by containing prescribed amounts of C, Si, Mn, P, S, Ni, Mo, Nb, Ti, Al and N, and, as occasion demands, one or more of B, V, Cu, Cr, Ca, REM and Mg, and regulating C, Si, Mn, Cr, Ni, Cu, V and Mo, those being elements to enhance hardenability, by a specific relational expression. The diameter of prior austenite grains may be regulated in a prescribed range. The method includes the steps of heating a casting to a temperature not lower than the Ac3 point, hot rolling it, and thereafter cooling the resulting hot-rolled steel plate at a prescribed cooling rate.