Patent SG-11201907335U-A (SG)
Title: Aminotriazolopyridines as kinase inhibitors
Inventor: GUO JUNQING
IPC: C07F9/09
Filed: 2018-02-12
Abstract: HN L A -- R 3 H 2 N L-A-R 3 R 2 O L A -- R 3 L - A R - 3 (V) L - A R - 3 A . R 3 R (VI) H 2 N R 1 (VII) R 2 (Viii) R 2 N (IX) H 2 N (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIPO I PCT ill 1111u°111110111sOHoI0 DIDIH1101IIIIIDiiIIII111111 DIIIIII (10) International Publication Number WO 2018/148626 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/501 (2006.01) C07F 9/09 (2006.01) A61K 31/4995 (2006.01) A61K 31/5377 (2006.01) A61K 31/4709 (2006.01) A61K 31/4545 (2006.01) A61K 31/55 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) A61K 31/444 (2006.01) (21) International Application Number: PCT/US2018/017755 (22) International Filing Date: 12 February 2018 (12.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/458,144 13 February 2017 (13.02.2017) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, NJ 08543 (US). = (72) Inventors: GUO, Junqing; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). HART, Amy, C.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). MACOR, John, E.; 55 Commanders Dri- ve, Washington Crossing, PA 18977 (US). MERTZMAN, Michael, E.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). PITTS, William, J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). SPERGEL, Steven, H.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Prince- ton, NJ 08543 (US). WATTERSON, Scott, Hunter; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). ANDAPPAN MU- RUGAIAH SUBBAIAH, Murugaiah; c/o Syngene In- ternational Limited, Biocon Special Economic Zone Bio- con Park, Plot No. 2&3 Bommasandra, Industrial Area IV Phase Jigani Link Road, Bommasandra, Karnataka, 560 099 Bangalore (IN). CHEN, Jie; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). DZIERBA, Carolyn, Diane; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). LUO, Guanglin; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). SHI, Jianliang; c/o Bris- (54) Title: AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS (57) : Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable c;;;;) salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), N (II), (III), (IV), (V), (VI), (VII), (VIII), (IX). O [Continued on next page] WO 2018/148626 Al MIDEDIMOMOIDEIREEMOMOIDIVIIIMIRODEVOIS tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). SIT, Sing-Yuen; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). (74) Agent: EPPERSON, James et al.; Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))