Patent SG-11201407037U-A (SG)
Title: Catechol o-methyltransferase activity inhibiting compounds
Inventor: AHLMARK MARKO
IPC: C07D333/60
Filed: 2013-05-23
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/175053 A1 (51) International Patent Classification: C07C 255/53 (2006.01) A61K 31/277 (2006.01) A61P 25/00 (2006.01) C07C 255/54 (2006.01) C07C 255/57 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01) C07C 311/29 (2006.01) C07C 317/22 (2006.01) C07C 321/28 (2006.01) C07C 321/30 (2006.01) C07D 265/30 (2006.01) C07D 207/08 (2006.01) C07D 207/337 (2006.01) C07D 277/30 (2006.01) (21) International Application Number: PCT/FI2013/000026 (22) International Filing Date: (25) Filing Language: (26) Publication Language: 23 May 2013 (23.05.2013) English English (30) Priority Data: 61/651,217 61/777,162 24 May 2012 (24.05.2012) US 12 March 2013 (12.03.2013) US (71) Applicant: ORION CORPORATION [FI/FI]; Orionintie 1, FI-02200 Espoo(FI). (72) Inventors: AHLMARK, Marko; Brinkinmalmi 7, FI- 02330 Espoo (FI). DIN BELLE, David; Louhentie 13 A 5, FI-02130 Espoo (FI). KAUPPALA, Mika; Vanha Puistolantie 11 F 23, FI-00760 Helsinki (FI). LUIRO, Anne; Oravatie 14, FI-00800 Helsinki (FI). PAJUNEN, Taina; Vuoritie 16, FI-02330 Espoo (FI). PYSTYNEN, Jarmo; Iivisniementie 6 A 5, FI-02260 Espoo (FI). TI- AINEN, Eija; Ruutikatu 3 A 17, FI-02650 Espoo (FI). VAISMAA, Matti; Alberganesplanadi 2 A 10, FI-02600 Es oo (FI). MESSINGER, Josef; Jukolanahde 6 A 2, FI- 02180 Espoo (FI). (74) Agent: ORION CORPORATION; Orionintie 1, FI- 02200 Espoo (FI). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS (•) © i> i-H (57) Abstract: Compounds of formula (I), wherein Ri is as defined in the claims, exhibit COMT enzyme inhibiting activity and are O thus useful as COMT inhibitors. CJ o &