Patent SG-11201808426X-A (SG)
Title: Compositions for treatment of wet age-related macular degeneration
Inventor: TRETIAKOVA ANNA
IPC: C07K16/22
Filed: 2017-04-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIM141101110101011111 HO 11111011101 111011011111100111011111011011# International Bureau 0.. .... .. ..... ..or::,„,' (10) International Publication Number (43) International Publication Date WO 2017/180936 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 48/00 (2006.01) C07K 16/22 (2006.01) kind of national protection available): AE, AG, AL, AM, C12N 15/86 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/027529 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 14 April 2017 (14.04.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/323,184 15 April 2016 (15.04.2016) US (84) Designated States (unless otherwise indicated, for every 62/331,100 3 May 2016 (03.05.2016) US kind of regional protection available): ARIPO (BW, GH, 62/442,946 5 January 2017 (05.01.2017) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/460,515 17 February 2017 (17.02.2017) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/466,721 3 March 2017 (03.03.2017) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: THE TRUSTEES OF THE UNIVERSITY LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Suite 200, Philadelphia, PA 19104 (US). GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventors: TRETIAKOVA, Anna, P.; 2531 Parrish Published: Street, Philadelphia, PA 19103 (US). WILSON, James, — M.; 1831 Delancey Street, Philadelphia, PA 19103 (US). with international search report (Art. 21(3)) — before the expiration of the time limit for amending the (74) Agents: KODROFF, Cathy, A. et al.; Howson & Howson claims and to be republished in the event of receipt of LLP, 350 Sentry Parkway, Building 620, Suite 210, Blue amendments (Rule 48.2(h)) Bell, PA 19422 (US). — with sequence listing part of description (Rule 5.2(a)) (54) Title: COMPOSITIONS FOR TREATMENT OF WET AGE-RELATED MACULAR DEGENERATION Rabbitpalobin CEP Mum% On 422A paVA i signal L - \ , ..'k 14 chain 1-1 a M 01 0 GC 1-1 L .. ' (57) : A recombinant adeno-associated :::;) provided herein. The rAAV comprises N elements which direct expression of 0 (aVEGF), a coding sequence for aVEGF, pression of the anti -VEGF Fab in the eye. Also provided herein are liquid suspensions containing these rAAV8.aVEGF and meth- ods of using same for treatment of wet AMD and other ocular conditions. a FIG 1 virus (rAAV) having an AAV8 capsid which is suitable for intra-retinal injection is a vector genome packaged within the capsid which contains, operably linked to regulatory anti- human vascular endothelial growth factor (VEGF) antigen binding antibody fragment wherein the coding sequence is operably linked to regulatory elements which direct ex -