Patent SG-11201810076W-A (SG)
Title: Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
Inventor: FERRARA KOLLER CLAUDIA
IPC: C07K14/705
Filed: 2017-05-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111011101 IIIIIIIIIIII100111111111111110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/194641 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, C07K 14/705 (2006.01) C07K 16/28 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 39/395 (2006.01) Cl 2N 15/62 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/EP2017/061241 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 11 May 2017 (11.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 16169487.2 13 May 2016 (13.05.2016) EP Declarations under Rule 4.17: (71) Applicant (for all designated States except US): F. HOFF- — of inventorship (Rule 4.17(iv)) MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). Published: — with international search report (Art. 21(3)) (71) Applicant (for US only): HOFFMANN-LA ROCHE — with sequence listing part of description (Rule 5.2(a)) INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). — = Inventors: FERRARA KOLLER, Claudia; c/o Roche (72) Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). = CLAUS, Christina; c/o Roche Glycart AG, Wagistrasse _ — 18, 8952 Schlieren (CH). KLEIN, Christian; c/o Roche = Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). SEE- BER, Stefan; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). AMANN, Maria; c/o Roche Gly- cart AG, Wagistrasse 18, 8952 Schlieren (CH). GRAU- = = RICHARDS, Sandra; c/o Roche Glycart AG, Wagis- trasse 18, 8952 Schlieren (CH). BRUENKER, Peter; c/o - = Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). _ UMANA, Pablo; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). LEVITSKI, Viktor; c/o Roche Gly- cart AG, Wagistrasse 18, 8952 Schlieren (CH). MOESSN- = _ = ER, Ekkehard; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). = Agent: KLOSTERMEYER, Doerte; F. HOFFMANN-LA (74) = ROCHE AG, Grenzacherstrasse 124, 4070 Basel (CH). = Designated States (unless otherwise indicated, for every (81) = — kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, — 1-1 1-1 71' HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 71' (54) Title: ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER AND PD1 BINDING MOIETY 1-1 ---- (57) : The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least IN , 1 one moiety capable of specific binding to PD1 and (b) a first and a second polypeptide that are linked to each other by a disulfide C::::) bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that N are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand 0 family member or a fragment thereof.