baber/WOPTO huggingface dataset:
Patent CA-2469204-A1 (CA)
Title: Prospective identification and characterization of breast cancer stem cells
Inventor: AL-HAJJ MOHAMMAD
IPC: A61K39/00
Filed: 2002-12-06
Abstract: Human breast tumors contain heterogeneous cancer cells. Using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice, we found that only a small minority of breast cancer cells had the capacity to form new tumors. The ability to form new tumors wa s not a stochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells a s CD44+CD24-/loLINEAGE-. As few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells fro m non-tumorigenic populations failed to form tumors. The tumorigenic cells cou ld be serially passaged, each time generating new tumors containing an expanded numbers of CD44+CD24-/lowLineage-tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscentof the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and n on- tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch4 induced tumorigeni c breast cancer cells to undergo apoptosis.
Patent CA-2470256-A1 (CA)
Title: Tampon medical
Inventor: GEHLING STEVEN CRAIG
IPC: A61F13/20
Filed: 2003-01-07
Abstract: L'invention concerne un tampon conçu afin de délivrer un agent thérapeutique, ce tampon comprenant un corps de tampon fabriqué dans un premier atelier, et une forme de dosage, couplée au corps, contenant une formulation comportant un agent thérapeutique, cette forme étant fabriquée dans un second atelier. L'invention concerne aussi un procédé de production d'un tampon médical consistant à fabriquer un corps de tampon dans un premier atelier, à fabriquer une forme de dosage dans un second atelier, cette forme contenant une formulation comportant un agent thérapeutique, et à coupler la forme de dosage au corps du tampon.
Patent CA-2473536-A1 (CA)
Title: Composition pharmaceutique et methode de traitement de troubles du systeme nerveux central
Inventor: SCHLAGHECK THOMAS G
IPC: A61K31/44
Filed: 2003-01-10
Abstract: Des troubles du système nerveux central (SNC) sont traités par l'administration d'un analogue de l'acide gamma-aminobutyrique (GABA) tel que la gabapentine ou la prégabaline, d'un antagoniste du récepteur NMDA tel que le dextrométhorphane ou la méthadone D et, éventuellement, d'une autre substance pharmacologiquement active, p. ex. une substance efficace dans le traitement d'un trouble du SNC.
Patent CA-2477380-A1 (CA)
Title: Dispositif pour fond de cavite corporelle dilatable
Inventor: EDER JOSEPH C
IPC: A61B17/12
Filed: 2003-03-27
Abstract: La présente invention concerne un dispositif de traitement d'anévrisme (10) permettant de traiter des anévrismes (14) de formes et de tailles diverses.
Patent CA-2478417-A1 (CA)
Inventor: CHAPMAN MICHAEL R
IPC: D02G3/44
Filed: 2003-04-21
Abstract: Fire retardant and heat resistant yarns, fabrics, and other fibrous blends incorporate one or more fire retardant and heat resistant strands comprising oxidized polyacrylonitrile and one or more strengthening filaments such as metallic filaments (e.g., stainless steel), high strength ceramic filaments, or high strength polymer filaments. Such yarns, fabrics, and other fibrous blends have a superior tensile strength, cut resistance, abrasion resistance, LOI, TPP and continuous operating temperature compared to conventional fire retardant fabrics. The yarns, fabrics, and other fibrous blends are also more soft, supple, breathable and moisture absorbent and are therefore more comfortable to wear, compared to conventional fire retardant fabrics. The inventive yarns may be woven, knitted or otherwise assembled into a desired fabric or other article of manufacture.
Patent CA-2481288-A1 (CA)
Inventor: COOPER MARY ELIZABETH
IPC: E04F21/06
Filed: 2004-09-14
Abstract: An apparatus for installation of a material having discrete elements. The apparatus includes a supply of material having discrete elements and an applicator assembly for activating a substantially water-free adhesive far providing structure to the material having discrete elements during installation. In the preferred embodiment, the applicator assembly includes a material nozzle having an inlet for receiving the material and an outlet for discharging a material stream to a surface; and an adhesive applicator adjacent to the material nozzle for activating a substantially water-gee adhesive to provide structure to the material having discrete elements during installation. Also, in the preferred embodiment, the adhesive applicator includes at least one impinging nozzle and at least one tacking nozzle. The apparatus may further include a transporter system downstream of the supply of material having discrete elements for delivery of the material to the applicator assembly.
Patent CA-2483251-A1 (CA)
Title: Multi-beam communication satellite antenna with failure compensation
Inventor: COROMINA FRANCESC
IPC: H01Q3/40
Filed: 2004-09-30
Abstract: A radio frequency radiation module comprising: a beam forming network capable of applying a signal including contributions to several beams, to several channels; each channel comprising a high power amplifier without redundant units, and an antenna radiating feed connected to the output of the amplifier, the beam forming network comprising a device for selective compensation for failure of one of the channels, increasing the power of the contribution of at least one of the said signals to a beam for which the radiation is affected by the failure.      The invention also reduces losses, and the cost, volume and mass of an antenna to be put into orbit and provided with failure compensation functions.
Patent CA-2485789-A1 (CA)
Title: Adjustable tool station
Inventor: DALESSANDRO FRANK
IPC: F16C29/00
Filed: 2003-05-14
Abstract: A miter saw (10) includes a tool adjustment unit having a joint (48) pivotable about an axis (A-A), a guide rail (40) spaced from and coupled to the joint (48) so as to pivot about the axis (A-A), a saw housing (38) mounted on the guide rail (40) and a linear motion bearing assembly (44), which is positioned between the guide rail (40) and the saw housing (38). The guide rail (40) and the linear motion bearing (44) are so shaped and dimensioned that the saw housing (38) and the guide rail (40) rotationally engage one another in a substantially play free manner to displace a saw blade (18) between a plurality of angled positions.
Patent CA-2486140-A1 (CA)
Title: Expandable stent having removable slat members
Inventor: POMERANZ MARK L
IPC: A61F2/06
Filed: 2004-10-28
Abstract: A medical device having an outer and an inner expandable stent in which the inner expandable stent is coaxially disposed within the outer expandable stent. The medical device further includes three removable slat members carried by the outer stent and three removable slat members carried by the inner expandable stent. The removable slat members provide a substantially continuous cover for the medical device and thus impede the flow of blood through the walls of the medical device. When deployed within a blood vessel, some of the slat members serve to cover an aneurysm and restrict the blood flow into the aneurysm; however, one or more of the slat members may be selectively removed to provide blood flow into a branching blood vessel.
Patent CA-2488185-A1 (CA)
Title: Method and apparatus for making plate-like fiber-reinforced products
Inventor: MOON DAVID
IPC: B29C44/32
Filed: 2003-06-04
Abstract: A method for making a plate-like fibre-reinforced product to be used as building or packing material, the method comprising: placing fibres on a lower laminate; applying a binding agent on the fibres so that the fibres are surrounded by the binding agent; transferring the fibres with binding agent between the lower laminate and an upper laminate between lower and upper rotating pressing plates (4, 3); allowing the binding agent to foam up, expand and harden between the upper and lower pressing plates. In order to economically manufacture such a product with desired physical and mechanical properties, the method comprises the steps according to which the fibres are made into a three-dimensional cohesive fibre mat of fibres bound together, the fibre mat having a moisture content of 5% at the most before the binding agent is applied onto the fibre mat, the binding agent is applied onto the fibre mat and the obtained mixture is subjected to a pressure of at least 0.8 bar and 5 bar at the most and is allowed to harden to a plate-like product having a thickness of 10 to 150 mm; and the lower and upper laminate are removed from the hardening product. The invention also relates to a manufacturing apparatus and a plate-like product.
Patent CA-2489288-A1 (CA)
Inventor: MATHIS RAYMOND
IPC: A61L15/34
Filed: 2003-06-03
Abstract: The invention describes compositions solid at 21 ~C for the finishing of nonwovens, comprising a) 5 to 70 % by weight of a component melting in the range from 25 to 37~C, chosen from the group of synthetic waxes, paraffins, fatty acid esters, polyhydroxy fatty acid esters, fatty alcohols, alkoxylate d fatty acid esters, alkoxylated fatty alcohols and mixtures of these compound s and b) 5 to 70 % by weight of a component whose melting point is at least 5 ~C higher than the melting point of component a), and component b) is chosen fr om the group of polyhydroxy fatty acid esters, C14 fatty alcohols, C12 fatty acids, the alkoxylated derivatives of the fatty alcohols and fatty esters, a nd mixtures of these components, where the compositions additionally comprise a s component. c) 5 to 25 % by weight of a crystallisation accelerator chosen fr om the group of partial glycerides, ethylene glycol diesters and polymeric waxe s, with the proviso, that the crystallisation accelerator has a melting point i n the range from 45 to 70 ~C, and the compositions comprise less than 5 % by weight of water.
Patent CA-2495842-A1 (CA)
Title: A closure assembly for a container
Inventor: BAUGHMAN GARY M
IPC: B65D39/08
Filed: 2005-02-03
Abstract: A closure assembly for a container including an internally-threaded annular flange, an externally-threaded closure plug that is received by the annular flange, and an annular gasket positioned between the annular flange and the closure plug for establishing a sealed interface. The container includes a container end panel that is formed over and around a portion of the annular flange and provides an inner axial wall that is positioned between the annular flange and the annular gasket. The clearance between the closing plug and the inner axial wall relative to the size of the annular gasket determines the degree of radial compression of the annular gasket as the plug is threaded into the flange. A radial lip of the plug is designed to contact an upper surface of the container end panel that is formed over the flange as a visual indication when the required tightening torque of the plug within the flange has been reached.
Patent CA-2496808-A1 (CA)
Title: Rail car door closer
Inventor: CLARK MELVIN GARY
IPC: B61D7/30
Filed: 2003-08-28
Abstract: A rail car door closer is provided to improve the speed and/or safety with which heavy rail car doors are closed to overcome deficiencies in conventional methods and devices relying on movement of the rail car or manual leverage.  The rail car door closer assembly (10) includes a movable base portion having a rotatable member (70) rotationally disposed thereon. The movable base portion is coupled to a drive system (40) configured to translate the movable base portion along a rail or a track (20) disposed adjacent a railroad track rail. Rotatable member (70) is positioned to contact an open rail car door and, upon movement of the movable base portion of the rail car door closer assembly (10) along the track (20) in a closing direction of the door, the door is closed.
Patent CA-2499490-A1 (CA)
Title: Amide and sulfonamide ligands for the estrogen receptor
Inventor: CHESWORTH RICHARD
IPC: C07D333/34
Filed: 2003-09-08
Abstract: The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodru gs thereof, and the pharmaceutically acceptable salts of the prodrugs, wherein R1, R2, R3, R4, R5, X, and Q are as defined herein. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) , and methods for treating or preventing diseases, disorders, conditions, or symptoms mediated by an ER which comprise administering to a mammalian subje ct in need of treatment therewith, an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof , or a pharmaceutically acceptable salt of the prodrug, or a pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug. The invention further provides pharmaceutica l compositions comprising combinations of the compounds of formula (I) and one or more of sodium fluoride, estrogen, a bone anabolic agent, a growth hormon e or growth hormone secretagogue, a prostaglandin agonist/antagonist, and a parathyroid hormone, and methods of treating or preventing diseases, disorders, conditions,or symptoms mediated by an ER comprising the administration of an effective amount of such combination to a mammalian subject in need of treatment therewith.
Patent CA-2499535-A1 (CA)
Inventor: JENSON CHRIS H
IPC: G02B6/02
Filed: 2005-03-07
Abstract: A light pipe with directional side-light extraction comprises a light pipe and light-extraction structure applied to the light pipe over only a part of the cross-sectional perimeter of the light pipe and over an active section of the length of the light pipe in which directional side lighting is desired. The light-extraction structure comprises any of (i) material, other than a light-carrying portion of the light pipe or any fluoropolymer cladding on the light-carrying portion, including light-scattering material, (ii) surfaces treated to have light-scattering properties, and (iii) material with a reflective property.  The foregoing light pipe eliminates the need for using a reflector, as with fluorescent lamps, by extracting the light only in the desired direction, towards a target area to be illuminated. Other embodiments of the invention promote uniformity in side light emission from a light pipe.
Patent CA-2501943-A1 (CA)
Title: Orally administered peptides synergize statin activity
Inventor: NAVAB MOHAMAD
IPC: A61K31/505
Filed: 2003-10-14
Abstract: This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high-density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the station permitting the station to be used at significantly lower dosages and/or cause the stations to be significantly more anti-inflammatory at any given dose.
Patent CA-2504511-A1 (CA)
Title: Agent for preventing or treating neuropathy
Inventor: SERA MISAYO
IPC: A61K31/66
Filed: 2003-10-30
Abstract: The present invention provides an agent for preventing or treating neuropath y having superior action and low toxicity. This agent comprises a compound represented by the formula:wherein ring A is a 5-membered aromatic heterocyc le containing 2 or more nitrogen atoms, which may further have substituent(s);B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;X is a divalent acyclic hydrocarbon group;Z is -O-, -S-, - NR2-, -CONR2- or -NR2CO- (R2 is a hydrogen atom or an optionally substituted alkyl group);Y is a bond or a divalent acyclic hydrocarbon group;R1 is an optionally substituted cyclic group, an optionally substituted amino group o r an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not b e - O-, or a salt thereof.
Patent CA-2507135-A1 (CA)
Title: Bi-directional infuser pump with volume braking for hydraulically controlling an adjustable gastric band
Inventor: HASSLER WILLIAM L JR
IPC: A61F2/00
Filed: 2005-05-12
Abstract: An implantable artificial sphincter system provides long-term adjustment via transcutaneous energy transfer (TET), minimizing invasive adjustment through adding or removing fluid via a syringe. An infuser device provides bi-directional fluid transfer via a flexible conduit to a sphincter band, such as a gastric band, by a combination of thermodynamic actuation and a piezo-electrically disengaged drum brake assembly that thereby achieves a desirable small volume device. A propellant within a propellant cavity surrounds a metal bellows accumulator biased at body temperature to either expand or collapse the bellows accumulator with the opposite direction of movement effected by a thermal element that heats in combination with a negatively-biased propellant or cools in combination with a positively-biased propellant. A drum brake assembly locks the metal bellows accumulator in place between adjustments by thermodynamic actuation by activating piezo-electric stack actuators that disengage calipers from a brake drum attached to the bellows accumulator.
Patent CA-2509605-A1 (CA)
Title: Alpha-2-delta ligand to treat lower urinary tract symptoms
Inventor: THORPE ANDREW JOHN
IPC: A61K31/4015
Filed: 2003-12-03
Abstract: Use of an alpha-2-delta ligand, or a pharmaceutically accepable derivative thereof, for the manufacture of a medicament for the treatment of LUTS, othe r than urinary incontinence, associated with OAB and/or BPH.
Patent CA-2518035-A1 (CA)
Title: Stirring apparatus and method of use of said apparatus
Inventor: PARTINGTON STEPHEN ROY
IPC: B01F7/00
Filed: 2004-02-27
Abstract: The present invention provides an apparatus comprising a vessel having a conduit extending therefrom, and a stirrer, a section of which is adapted to be located within the conduit and a section of which is adapted to be located within the vessel, said stirrer being adapted such that, in use, material within the conduit is conveyed in a direction towards the vessel and/or in a direction away from the vessel.
Patent CA-2520674-A1 (CA)
Title: Process for making substituted pyrazoles
Inventor: FEVIG TOM
IPC: C07D401/04
Filed: 2004-03-30
Abstract: This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I) wherein R3A R3B R3C, Y1, Y2, Y3, Y4, and Y5 are as defined in the specification.
Patent CA-2521638-A1 (CA)
Inventor: LUO JING
IPC: C12N9/24
Filed: 2004-04-05
Abstract: The invention relates to processes for treating a pulp, and for making a paper material such as paper, cardboard, linerboard, corrugated paperboard, tissue, towels, corrugated containers, boxes etc., these processes comprising an alkaline treatment of a pulp, a treatment with a pectin lyase and/or a pectate lyase, and, if desired, a draining of the pulp. Pectate lyase in combination with pectinesterase may be substituted for pectin lyase. The invention also relates to the use of xylanase, pectin lyase, pectate lyase, and/or the combination of pectate lyase with pectinesterase for anionic trash reduction and/or reduction of cationic demand of a paper pulp.
Patent CA-2521851-A1 (CA)
Inventor: NICHOLSON MICHAEL E
IPC: A61F2/00
Filed: 2004-04-09
Abstract: An ostomy appliance cover (40) that includes a first sheet (44) of flexible material having at least one low coefficient of friction surface (45) and dimensioned to cover a first portion (28) of the ostomy appliance (20) and a second sheet (48) of flexible material that is elastic and breathable, dimensioned to cover a second portion (29) of the ostomy appliance (20). The second sheet (48) of material includes an expandable opening (46), which when expanded allows the ostomy appliance to pass through the opening without substantial distortion of the ostomy appliance, and when released substantially covers the colostomy appliance in cooperation with the first sheet (44) of material.
Patent CA-2521883-A1 (CA)
Title: Indene derivatives as pharmaceutical agents
Inventor: HE YUEHUA
IPC: C07C69/013
Filed: 2004-04-15
Abstract: Compounds of formula (Ia): wherein R1, R2, R3, R4a, R4b, R5 and R6 are defined herein, as well as other indene derivatives are disclosed herein.  Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
Patent CA-2522474-A1 (CA)
Title: Air seeder disc scraper
Inventor: HARMON BARRY
IPC: A01C7/20
Filed: 2005-10-05
Abstract: A scraper for a single-disc opener air seeder, comprising a mounting bracket, scraper attachment member, scraper plate, scraper edge containment member, scraper edge, bolt, spring, and nut, wherein the scraper attachment member is attached to the mounting bracket by the bolt, wherein the mounting bracket comprises a main surface, wherein the bolt comprises a top end, wherein the nut is screwed onto the top end of the bolt, wherein the spring lies between the main surface of the mounting bracket and the nut on the top end of the bolt, wherein the scraper attachment member is connected to the scraper plate, wherein the scraper plate is connected to the scraper edge containment member, and wherein the scraper edge containment member is connected to the scraper edge. Two different embodiments of the mounting bracket for installation on the seed/fertilizer boot and depth wheel sides of the opener disc.
Patent CA-2524722-A1 (CA)
Title: Acylated nonadepsipeptides
Inventor: RAGOT JACQUES
IPC: C07K5/06
Filed: 2004-04-27
Abstract: The invention relates to nonadepsipeptides, methods for the production thereof, and the use thereof for producing medicaments utilized in the treatment and/or prevention of diseases, especially infectious bacterial diseases.
Patent CA-2525820-A1 (CA)
Title: Two wire touch sensor interface
Inventor: HOEKSTRA ERIC J
IPC: H02J1/00
Filed: 2004-05-13
Abstract: A touch sensor interfaces with a control system or controlled device using two wires. The output of the touch sensor controls an output switch.
Patent CA-2526606-A1 (CA)
Title: Golf swing training device and method
Inventor: SHEW BLAIK F
IPC: A63B69/36
Filed: 2004-05-20
Abstract: A golf swing training aid includes a shaft (12) having two sliding elements (30, 32) which are moved from initially coupled positions on the shaft to impact positions during the backswing and downswing make distinctive sounds at impact positions to aid in setting the club and hinging the shaft when executing the backswing and lagging of the club during the downswing. Grip protrusions are biased against webs of the fingers for enhanced power generated during the swing.