Patent SG-11201808541V-A (SG)
Title: Recombinant intravenous immunoglobulin (rivig) compositions and methods for their production and use
Inventor: HSU YEN-MING
IPC: C07K19/00
Filed: 2017-03-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111010111110111111111011001111101111011111 International Bureau ... .1 j (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/172853 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: DO, C07K 19/00 (2006.01) C07K 14/47 (2006.01) HN, KP, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/US2017/024650 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, 29 March 2017 (29.03.2017) TH, ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, 62/315,483 30 March 2016 (30.03.2016) US TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: AB BIOSCIENCES, INC. [US/US]; 214 Lin- DK, coin St. Ste 402, Aliston, MA 02134 (US). LV, SM, (72) Inventors: HSU, Yen-Ming; 214 Lincoln St. Ste 402, Al- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, iston, MA 02134 (US). LEE, Jeng-Shin; 214 Lincoln St. GW, KM, ML, MR, NE, SN, TD, TG). Ste 402, Aliston, MA 02134 (US). CHANG, Hsiu-Ching; Published: 214 Lincoln St. Ste 402, Aliston, MA 02134 (US). — with international search report (Art. 21(3)) (74) Agent: LAZAR, Steven, R.; 234 Broadway, Arlington, before the expiration of the time limit for amending the MA 80709 (US). claims and to be republished in the event of receipt of Designated States (unless otherwise indicated, for every amendments (Rule 48.2(h)) (81) kind of national protection available): AE, AG, AL, AM, _ with sequence listing part of description (Rule 5.2(a)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Title: RECOMBINANT INTRAVENOUS IMMUNOGLOBULIN (RIVIG) COMPOSITIONS AND METHODS FOR THEIR (54) AND USE = PRODUCTION (57) : Compositions of recombinant in- FIGURE 1. CONSTRUCTS OF rIVIG MOLECULES travenous immunoglobulin (rIVIG) proteins and methods for purification and use of rIVIG pro- teins. The compositions comprise oligomeric Fc P700511 iiii Chi .: 043 p v : : molecules which bind to Fc receptors with high P80022 r - r.IIT T - air .1 ''' ek2 7 , 51T iiiiroiiFT avidity. The rIVIG proteins are useful as immun- °modulatory molecules for the treatment of im- P8002Z IL .q 4 . - 2.. 1 .c.ta. RR jP...91.: 2 ,.. P2003Z .A. ,k i ai :i II..R.[ Ziii Ii 1.. ail oy g o. mune disorders including autoimmune diseases, such as refractory immune thrombocytopenia, chronic inflammatory demyelinating polyneuro - P 80042 ItiL clf?.. „ „ ili?.. \"' !Al.?.. LH?: :11{.Pk...?.. pathy, multiple sclerosis, lupus, Graves Disease, Kawasaki disease, dermatomyositis, myasthenia MOM .gl2i!...H1. .g. 'i.. ffik ,it SAC c9....M14..... 0.4.. .01: gravis, Guillam-Bane syndrome, autoimmune hemolytic anemia, and other immune and inflam- Structural components matory conditions. The rIVIG proteins can also be Human hg kappa light chain constant region ' Human 101 hinge used as immunomodulators in patients to reduce 11 L cli Hunan 1261 heavy chain constant region 1 LIj (GGGGSit the immune rejection of organ transplants, stem ._ N.. _: Hunan IgG1Ixakry chain constant region 2 (GGGGS)/ cell transplants and bone marrow transplantation. M ....m.... Human IgG1 heavy crialn constant region 2 (GGGGSk, ORE CD40 Ilgargleach\"acellular domain (GGGGSh Additionally, the present invention provides rIVIG kr) Collagen XXI GPI repeat • nca domain - c ann a:: : . proteins of non-human origin, for use in veterinary pt immune oxia. Mannose binding domain disorders, such as canine rIVIG proteins N protein trimeriting IN for the treatment of dogs suffering from autoim- mune hemolytic anemia, immune thrombocyt- t - - openia purpura, rheumatoid arthritis, or other can- 11 ine immune disorder. 0 N C