Patent SG-11201805052Y-A (SG)
Title: Therapeutic methods using erythrocytes
Inventor: KARSTEN ELISABETH
IPC: A61P35/00
Filed: 2016-12-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111101111011101010111110101111101110101101101111011101101111101111001111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/106899 A3 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: AO, A61K 35/18 (2015.01) C12N 5/00 (2006.01) BZ, A61P 35/00 (2006.01) GO1N 33/50 (2006.01) DO, A61P 37/00 (2006.01) GO1N 35/00 (2006.01) HN, A61K 48/00 (2006.01) KP, MD, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, PCT/AU2016/000404 RU, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, 22 December 2016 (22.12.2016) ZA, ZM, ZW. TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 2015905309 22 December 2015 (22.12.2015) AU TJ, DK, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: SANGUI BIO PTY. LTD [AU/AU]; 63 LV, Kangaroo Street, Manly, NSW 2095 (AU). SM, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: KARSTEN, Elisabeth; 20/14-16 Campbell GW, KM, ML, MR, NE, SN, TD, TG). Street, Northmead, NSW 2152 (AU). HERBERT, Ben; 3 Published: Douglas Avenue, North Epping, NSW 2121 (AU). LIDDLE, Alan; 63 Kangaroo Street, Manly, NSW 2095 with international search report (Art. 21(3)) (AU). HILL, Cameron; 1201/1 Sergeants Lane, St Le- — before the expiration of the time limit for amending the onards, NSW 2065 (AU). claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Agent: SPRUSON & FERGUSON; GPO Box 3898, (74) = Sydney, NSW 2001 (AU). (88) Date of publication of the international search report: 28 September 2017 Designated States (unless otherwise indicated, for every kind of national available): AE, AG, AL, AM, protection = (81) M C:r C:r GC 0 1-1 IN 1-1 (54) Title: THERAPEUTIC METHODS USING ERYTHROCYTES 0 N (57) : The present disclosure relates to methods for modulating the level of proteins in a subject or in target cells by priming en. ) red blood cells with various agents or conditions that modulate the levels of proteins associated with red blood cells and administer - ing the primed red blood cells to a subject. The disclosed methods represent a novel use of red blood cells primed to express a num - .,. ber of proteins, as cell therapies for numerous diseases or disorders.