baber/WOPTO huggingface dataset:
Patent CA-2471910-A1 (CA)
Title: Benzocyclodecane derivatives with antitumor activity
Inventor: CIOMEI MARINA
IPC: C07C69/618
Filed: 2002-12-18
Abstract: A compound which is a benzocyclodecane of the formula I wherein: ----- at positions 8-9 and 11-12 independently represents a single or double bond, -R 1 is =O, or -OR7, R7 is H, C1-C7 alkanoyl, benzoyl, C1-C10 alkyl, C2-C10 alken yl or COCH=CHR8, R8 is aryl or heterocyclyl;-R2 and -R3 are H, =O or -OR9, R9 i s H, C1-C7 alkanoyl or benzoyl; when at position 11-12 there is a single bond, then -R4 represents=O, =CH2, =CHCOOR10, R10 is C1-C10 alkyl or aryl; =CH(OCH3), -OR9; -CH2OR11, R11 is H or a sugar residue, -COR12 , R12 is H, - OH or -OR10; or when at position 11-12 there is a double bond, then -R4 is - CH2OR11 or -COR12; - R5 and -R6 are H or, when at position 8-9 there is a single bond, taken together form a cyclopropane ring; R13 is H or 1-3 substituents selected from C1-C6 alkyl, C2-C6 alkenyl, phenyl, phenyl C1-C6 alkyl, halogen, hydroxy, C1-C6 alkoxy, aryloxy, cyano, nitro, amino, C1-C10 alkylamino, arylamino, C1-C7 alkanoylamino, aroylamino, hydroxycarbonyl, aminocarbonyl, C1-C6 alkylcarbonyl, C1-C6 alkylaminosulfonyl and arylaminosulfonyl group; with the provisos that if R1 and R4 =O, then one of R2, R3, R5, R6 and R13 is not H atom; or a pharmaceutically acceptable salt thereof. These benzocyclodecane derivatives are endowed with antitumor activity; a process and new intermediates fortheir preparation, the pharmaceutical compositions containing them, and their use in the prevention , control and treatment of cancer are also provided.
Patent CA-2473308-A1 (CA)
Title: Assay and kit for analyzing gene expression
Inventor: PEDERSEN MORTEN LORENTZ
IPC: C12N15/10
Filed: 2002-01-24
Abstract: It is one objective of the present invention to obtain reproducible representations of expressed mRNA molecules by exploiting a novel technique that relies on short, single stranded polynucleotide tags. In one preferred embodiment, only one polynucleotide tag is obtained from each mRNA molecule, and relatively simple counting statistics can thus be applied after identification and sampling of the different tags, or a subset of tags being present in the population of representative tags. The tags according to the present invention are preferably single stranded polynucleotide tags obtained by subjecting genetic material derived from a biological sample to at least one site-specific nicking endonuclease capable of i) recognizing a predetermined nucleotide motif comprising complementary nucleotide strands and ii) cleaving only one of said complementary strands in the process of generating the at least one single stranded polynucleotide tag. Accordingly, the present invention demonstrates that nicking endonucleases may advantageously be used for obtaining and isolating ssDNA tags. This novel approach in one embodiment eliminates the occurrence of any linker sequence in the ssDNA tag, and it eliminates the presence of a complementary strand in the isolated polynucleotide tag. The lack of linkersequence in the tag and the lack of any complementary strand serves to reduce the huge complexities associated with the analysis of expressed molecules in a biological sample.
Patent CA-2474783-A1 (CA)
Title: Pluripotent embryonic-like stem cells derived from teeth and uses thereof
Inventor: ZEILHOFER F
IPC: A61K35/12
Filed: 2003-02-05
Abstract: A stem cell which is obtainable from the non-embryonic tissue isolated from the dental follicle of tooth or wisdom tooth which are able to differentiate into a periodontal ligament like membrane structure.
Patent CA-2476682-A1 (CA)
Title: Amine acid zwitterion additive for a cathodic electrocoating composition
Inventor: CHUNG DING YU
IPC: C08G18/80
Filed: 2003-02-20
Abstract: This invention is directed to an improved aqueous cathodic electrocoating composition and a method for the electrodeposition of this composition; the composition comprises a cathodic electrodepositable composition comprising a binder of (a) a cathodically electrodepositable film forming resin and (b) a polyisocyanate crosslinking agent blocked with a compound that is non-hazardous and non-air polluting, such as, an alkoxy alkanol or an alkyl alcohol; wherein the improvement comprises the use of 0.1-5.0% by weight, based on the weight of the binder, of a water miscible amine acid zwitterion additive which is the reaction product of an amine acid and an alkylglycidy ether.
Patent CA-2479337-A1 (CA)
Inventor: BIRNE-BROWNE RONALD
IPC: B21K5/02
Filed: 2004-08-27
Abstract: A roller cone drill bit includes a bit body adapted to be coupled to a drill string, a bearing journal depending from the bit body, and a single roller cone rotatably attached to the bearing journal. The single roller cone has a plurality of cutting elements, where at least one of the plurality of cutting elements is formed of an inner region that is at least partially surrounded by an outer region, where the inner region is more abrasive resistant than the outer region. Such an arrangement in a single roller cone bit allows the at least one cutting element to be "self sharpening."
Patent CA-2479930-A1 (CA)
Inventor: ZHANG LUYAN
IPC: C07D217/14
Filed: 2003-03-25
Abstract: L'invention concerne des tétrahydroisoquinoléines substituées et leurs composés associés. De tels composés sont des ligands que l'on peut utiliser pour moduler l'activité du récepteur C5a in vivo ou in vitro et conviennent particulièrement au traitement de pathologies associées à l'activation du récepteur C5a pathologique chez les humains, les animaux domestiques et le bétail. L'invention concerne également des compositions pharmaceutiques et leurs procédés d'utilisation dans le traitement de tels troubles, notamment les procédés d'utilisation de tels ligands dans l'analyse de la localisation du récepteur.
Patent CA-2480175-A1 (CA)
Inventor: WILLIAMS STEPHEN
IPC: G01N37/00
Filed: 2003-04-01
Abstract: The invention provides methods and algorithms for measuring one or more analytes in a sample by using a plurality of releasable molecular tags attached to binding compounds specific for the analytes of interest. After binding compounds specifically bind to their respective analytes to form complexes, the molecular tags of the binding compounds forming such complexes are cleaved and released, while the molecular tags of those binding compounds not forming such complexes are not released. The released molecular tags are then electrophoretically separated along with one or more electrophoretic standards to generate electropherogram data, and the identity of each molecular tag is determined by the location of its corresponding peak in such data relative to the one or more of the electrophoretic standards. In this way, distortions in the electropherogram data due to factors such as instrumentation differences, assay conditions, reagent variability, or the like, can be taken into account and experimental results from different electrophoresis systems, different assays, or the like, may be compared.
Patent CA-2482378-A1 (CA)
Inventor: WEISS WILLY
IPC: A61M35/00
Filed: 2004-09-23
Abstract: The invention relates to an applicator device for applying a liquid, pasty, gel-like, wax-like or powder product such as a cosmetic. The applicator device has a metal mesh component, said metal mesh having a weave with twill bonds.
Patent CA-2482864-A1 (CA)
Inventor: LALIBERTE RICHARD
IPC: H01M50/562
Filed: 2003-04-30
Abstract: The invention provides an EC bundle having a plurality of cells. In turn, ea ch cell respectively comprises: a pair of sheet-like electrodes; electrolyte interposed between the electrodes; and a sheet-like current collecting element. The sheet-like current collecting element, which includes a pair of generally opposite main faces, projects from at least one of the sheet-like electrodes and is electrically connected thereto. Moreover, the plurality of cells are arranged into a stack such that their respective sheet-like curren t collecting elements are in a side-by-side relationship with their main faces generally facing one another. The EC bundle further comprises a current collecting terminal featuring apart relationship which define a recess which receives the sheet-like current collecting elements and which establishes an electrical connection with them. The arms of the current collecting terminal overlap at least a portion of a main face of one of the sheet-like current collecting elements.
Patent CA-2483573-A1 (CA)
Inventor: NEITZEL MARTIN
IPC: C07D241/36
Filed: 2003-05-02
Abstract: La présente invention a trait à des dérivés d'acétamide sulfonylquinoxalone et composés associés utiles en tant qu'antagonistes de la bradykinine pour le soulagement de symptômes, liés à la bradykinine, l'inflammation, la bronchoconstriction, l'oedème cérébral et analogues.
Patent CA-2484412-A1 (CA)
Title: Dispensing closure having complete peripheral seal
Inventor: SKILLIN CLIFFORD WAYNE
IPC: B65D47/08
Filed: 2004-10-08
Abstract: A dispensing closure for a container comprising a closure body adapted to be mounted on the container. The closure body has a dispensing orifice and a sealing cap. A pair of adjacently spaced living hinges connect the sealing cap to the closure body for movement between an open and a closed position. The closure body and sealing cap have sealing elements that provide a complete peripheral seal between the sealing cap and the closure body when in the closed position. The sealing cap has a camming lug located between the living hinges, and contacting the sealing elements on the closure body without impairing the integrity of the sealing elements, and further provides a snap-action to the movement of the sealing cap from the open to the closed position.
Patent CA-2485053-A1 (CA)
Inventor: RIEBE HENNING
IPC: G06Q30/00
Filed: 2003-05-09
Abstract: Publié sans précis
Patent CA-2488708-A1 (CA)
Inventor: TRETIAKOVA ANNA A
IPC: C12N5/0783
Filed: 2003-06-17
Abstract: L'invention concerne la découverte du fait que la signalisation par le biais d'un récepteur de sérotonine de type 1B, 2, 4 et 6 est importante dans l'activation des cellules T, de sorte que l'inhibition d'une telle signalisation, par exemple par utilisation de fluphénazine, peut servir à moduler notamment la réponse immunitaire, la prolifération cellulaire et l'apoptose. Cette immunomodulation est utile dans le traitement de maladies ou d'états immunologiques, et dans le développement de thérapeutiques éventuelles pour de tels maladies ou états. En outre, dans les cellules impliquées dans le processus de cycle cellulaire, l'inhibition de la signalisation de la sérotonine inhibe le processus et induit l'apoptose et des changements morphologiques d'une cellule. Cette action d'inhibition de la signalisation sérotonergique peut servir à tuer de manière sélective des cellules et à identifier des composés qui inhibent la signalisation. En outre, l'invention concerne des procédés d'utilisation, d'identification et de production d'un inhibiteur qui sensiblement ne traverse pas la barrière hémato-encéphalique.
Patent CA-2491981-A1 (CA)
Inventor: O'CONNOR LAWRENCE J
IPC: B32B9/00
Filed: 2005-01-11
Abstract: A covering is provided for exterior application on solid surfaces such as patios, docks, and walkways. The covering is formed as tiles formed of a top layer of fibrous material, such as carpet, and a bottom layer of adhesive applied at a basis weight of between 185 - 1000 gsm. The adhesive layer may have beads formed on the edges that function as integral gaskets. The beads on adjacent tiles work together to form sealed seams throughout the installation. A release sheet, preferably formed of plural pieces, is secured over the adhesive for removal during installation. A portion of the release sheet can function as a positioning strip.
Patent CA-2492128-A1 (CA)
Inventor: GUAY DANIEL
IPC: C25B11/04
Filed: 2005-01-05
Abstract: L'invention vise un alliage répondant à la formule suivante: Ti2+t(Ru(1-x)Al(1+x))(1-u/2)M u T y dans laquelle: t est un nombre compris entre -1 et +1 et de préférence entre -0.5 et + 0.5; x est un nombre compris entre -0.95 et +0.95 et de préférence entre +0.5 et + 0.95; u est un nombre compris entre 0 et +1, de préférence inférieur à 0.25; y est un nombre compris entre 0 et +6, de préférence égal à 2 M représente un ou plusieurs éléments choisis parmi Ag, Pd, Rh, Fe, Cr et V, les éléments étant de préférence Ag, Pd ou Rh, et T représente un ou plusieurs éléments choisis parmi O, B, S, C, N, Si, P et H, les éléments étant de préférence de l'oxygène. Cet alliage est de préférence à l'état nanocristallin et peut être utilisé comme cathode pour produire par voie électrochimique le chlorate de sodium.
Patent CA-2500218-A1 (CA)
Inventor: SAKO KAZUHIRO
IPC: A61K9/14
Filed: 2003-09-25
Abstract: To produce an agent for improving drug adsorption by a mucous layer in the digestive tract, use is made of one or more members selected from among polyethylene glycol, polyethylene oxide and polyoxyethylene-polypropylene copolymer having 17 or more moles of single chain length ethylene oxide adde d per molecule. By applying such an agent to a drug having an activity against Helicobacter pylori, the pharmacological effect of the drug can be enhanced.
Patent CA-2502500-A1 (CA)
Inventor: FRANKLIN JAMES BRUCE
IPC: G02B6/00
Filed: 2003-10-24
Abstract: The present invention provides a light transfer component formed from a material that is transparent for light of a predetermined range of wavelengths. The light transfer component comprises a first substantially fl at portion, a second rounded portion, and an intermediate portion disposed between the first and the second portion. The light transfer component is arranged for guiding light from the first portion through the intermediate portion to the second portion in a manner such that the light will not experience a reduction in cross-sectional area of more than 20 % of the material through which it is guided.
Patent CA-2502815-A1 (CA)
Title: Method and apparatus for isolating aircraft equipment
Inventor: STICKLING BJORN
IPC: G06F17/00
Filed: 2005-03-31
Abstract: A system and method for interfacing equipment with flight Aircraft Equipment without causing interference between same. An isolation module includes transmission and power control functionality for ensuring safe and secure operation of the equipment on the aircraft.
Patent CA-2504137-A1 (CA)
Inventor: GHOLMIEH AZIZ
IPC: H04B7/005
Filed: 2003-10-28
Abstract: A mobile wireless terminal (MWT) includes multiple wireless modems. The multiple modems have their respective transmit outputs combined to produce a n aggregate transmit output. The multiple modems can concurrently transmit dat a in a reverse link direction and receive data in a forward link direction. Th e MWT is constrained to operate under an aggregate transmit power limit. Each of the multiple modems has an individual transmit limit related to the aggregat e transmit power limit. When operating, over-limit ones of the multiple modems are deactivated and then reactivated to keep an aggregate transmit power of all of the modems below the aggregate limit, and to maximize data through-pu t on the forward and reverse links.
Patent CA-2504175-A1 (CA)
Inventor: OZAWA KAZUNORI
IPC: G10L21/04
Filed: 2003-10-16
Abstract: A bandwidth expanding device comprising a spectrum parameter calculating circuit (100) for calculating a spectrum parameter of a narrow-bandwidth input signal x(n), a coefficient calculating circuit (130) for receiving the spectrum parameter and converting it into the coefficient of a signal the bandwidth of which is expanded, a gain circuit (140) for receiving a gain from a gain control circuit (210), multiplying the output signal from a noise generating circuit (120) and the gain, and outputting the product to a combined filter circuit (170), the combined filter circuit (170) for receiving the coefficient from coefficient calculating circuit (130) to constitute a filter and passing the signal from the gain circuit (140) through the filter to output a high-frequency signal y(n) for bandwidth expansion, a sampling frequency converting circuit (180) for receiving the narrow-bandwidth input signal x(n) and outputting a signal s(n) the frequency of which is up-sampled to a predetermined sampling frequency, and an adder (190) for adding the high-pass signal y(n) to the signal s(n) and outputting an expanded bandwidth signal.
Patent CA-2504650-A1 (CA)
Inventor: CHERNOMORSKY ARY S
IPC: A61B18/14
Filed: 2003-06-26
Abstract: Devices and methods for cutting and collecting a specimen (904) from a mass of tissue. The device (100) may include an integrated cut and collect assembly (108). The integrated cut and collect assembly includes a cutting portion (116) and a collection portion (114) that includes a flexible membrane. The collection portion (114) of the assembly is attached to the cutting portion (116) thereof. The cutting portion (116) is configured to cut the specimen (904) from the mass of tissue and the collection portion (114) is configured to collect the cut specimen (904) and to encapsulate and isolate the cut specimen (904) within the membrane (114) to enable its safe retraction from the mass of tissue.
Patent CA-2504999-A1 (CA)
Title: Therapeutic compounds and methods
Inventor: MEURER-GRIMES BARBARA MARTHA
IPC: A61P9/10
Filed: 2003-11-06
Abstract: The present invention provides compounds having a cyclopentabenzofuran core and the use of such compounds in therapy as well as compositions comprising said compounds.
Patent CA-2505547-A1 (CA)
Title: Dispositif optique
Inventor: BORG PATRIK
IPC: G02B30/60
Filed: 2003-11-03
Abstract: L'invention concerne un dispositif permettant à un observateur de voir un objet localisé au-dessous de ses yeux, alors que ses yeux sont dirigés sensiblement vers l'avant, dispositif comprenant un premier et un second miroirs agencés de manière à fournir un parcours optique allant de l'objet vers une surface réfléchissante du premier miroir, puis vers une surface réfléchissante du second miroir, puis vers les yeux. Le dispositif comprend un cadre et est agencé de façon que lors du positionnement du cadre et des miroirs situés devant et à distance du corps d'un observateur ayant la partie supérieure de son corps sensiblement verticale, et tenant ses mains en un emplacement situé devant la partie supérieure de son corps, et ayant ses yeux dirigés sensiblement vers l'avant, ce dispositif montre les mains de l'observateur.
Patent CA-2506364-A1 (CA)
Inventor: MILLS MARTIN FREDERICK
IPC: C09D7/12
Filed: 2003-11-27
Abstract: L'invention concerne une composition de microgel comprenant des particules de microgel dont le poids moléculaire moyen dépasse 50 000, une solution à 60 % eau dans eau de ce microgel dans du dioxane ayant une viscosité inférieure à 10 Pa.s, mesurée par viscosimétrie cône-plan.
Patent CA-2507889-A1 (CA)
Inventor: MUELLER BERND
IPC: C07D401/12
Filed: 2003-12-03
Abstract: L'invention concerne un nouveau procédé de préparation de (S)-pantoprazole faisant appel à un complexe de zirconium chiral ou à un complexe d'hafnium chiral.
Patent CA-2510654-A1 (CA)
Title: Antigens for actinobacillus pleuropneumoniae and methods thereof
Inventor: SIROIS MARC
IPC: A61K39/00
Filed: 2002-12-18
Abstract: The present invention is related to a DNA sequence of outer membrane protein s of Actinobacillus pleuropneumoniae expressed in a subject suffering from pleuropneumonia, the sequence coding for the receptor for the uptake of ferr ic hydroxamate FhuA as set forth in SEQ ID NO: 1 in Actinobacillus pleuropneumoniae, or any functional fragment thereof. The present invention also relates to a DNA sequence of outer membrane proteins of Actinobacillus pleuropneumoniae expressed in a subject suffering from pleuropneumonia, the sequence coding for a hemoglobin-binding protein as set forth in SEQ ID NO: 4 in Actinobacillus pleuropneumoniae, or any functional fragment thereof. The present invention further relates to composition, diagnostic kit and methods using the DNA sequences of the present invention.
Patent CA-2513396-A1 (CA)
Inventor: ALBERT KENT P
IPC: B02C7/12
Filed: 2005-07-22
Abstract: A refiner plate has an outer circumferential edge, a front surface having comminuting projections, and a rear surface. The refiner plate also has and a single mounting opening radially inward from the outer circumferential edge. The refiner plate also includes a radially extending key attached to the rear surface, the key having an end forming a tab that extends past the plate outer circumferential edge.
Patent CA-2514935-A1 (CA)
Title: Amine-initiated polyether polyols and a process for their production
Inventor: HEADLEY KEITH J
IPC: C08G18/40
Filed: 2004-02-19
Abstract: Clear, amine-initiated polyether polyols are made by epoxidizing an amine in the presence of an alkali metal hydroxide catalyst. By reducing the amount of catalyst used during the polyol synthesis and by adding the catalyst after between 5 and 30% of the total amount of at least one alkylene oxide has been added, after lactic acid neutralization, gives a short chain polyol that has foam processing characteristics similar to the conventional sulfuric acid neutralized polyol. The polyols produced in this manner are particularly useful for the production of polyurethane and polyisocyanurate foams.
Patent CA-2515496-A1 (CA)
Title: Pump or turbine, drive unit comprising such a pump or turbine and outboard motor
Inventor: NEEB TACO WIJNAND
IPC: F04D5/00
Filed: 2004-02-25
Abstract: The invention relates to a pump or turbine comprising a housing provided with at least one chamber, a rotor, which is ratably mounted on a shaft in the chamber, an inlet, which communicates with the chamber at least at the location of the shaft, and an outlet channel, which communicates with the chamber at least at the periphery of the rotor. The pump or turbine moreover comprises at least one bypass channel, a first end of which opens into the outlet channel of the pump and a second end of which forms an inlet. The bypass channel may be used for increasing the propelling force or for pumping slurries, for example.
Patent CA-2520212-A1 (CA)
Title: Rush hour modelling for routing and scheduling
Inventor: MUDD THOMAS
IPC: G06Q10/00
Filed: 2004-04-15
Abstract: A rush hour modeling system that is configured for modifying existing travel time/distance data to reflect special traffic conditions, such as rush hour traffic conditions. The system is configured to receive information defining one or more time windows, geographic areas, and road segments in which special traffic conditions occur. The system is also configured to receive travel rules that reflect the special traffic conditions. The travel rules are used to modify a travel time/distance matrix to reflect the effect of the special traffic conditions on ~normal~ travel times and distances. Existing routing and scheduling systems can then use the modified travel matrix to plan and schedule routes for delivery vehicles more accurately. Additionally, the modified travel matrix can be used to model traffic conditions through a particular geographic area or on a particular road segment.
Patent CA-2520292-A1 (CA)
Inventor: HERR ALLEN CHRIS
IPC: A61G13/08
Filed: 2005-09-21
Abstract: A medical examination table 10 has a seat section 14 and a back section 16 supported on a base 12. The seat and back sections 14, 16 are selectively adjustable to place a patient resting thereon in various positions for examination or the performance of medical procedures. The seat section 14 has a relatively low profile that accommodates storing various accessories beneath the seat section 14 while providing a high level of patient comfort and ensuring a low overall table height. In one embodiment, the seat section 14 comprises a seat frame 30 having a central open area 32, and a layer of web material 34 extending over the open area 32.
Patent CA-2522382-A1 (CA)
Inventor: OTTENBREIT MARLAND R
IPC: B22D11/126
Filed: 2005-10-27
Abstract: A method for treating cracks in slabs involving a step of positioning at least one cutting torch along a slab processing line. The at least one cutting torch being positioned to cut a corner where cracking commonly occurs from the slab at it passes along the slab processing line.