Patent GB-994734-A (GB)
Title: Self-propelling powder-dispensing compositions
IPC: A61K9/00
Filed: 1963-10-30
Abstract: A self-propelling powder-dispensing composition comprises a finely-divided powder suspended in a liquefied propellant having a vapour pressure of at least 13 lbs. per square inch gauge at 70 DEG F. and a liquid non-ionic surface-active agent having a hydrophilelipophile balance of less than 10 which surface-active agent is dissolved in said liquefied propellant, the said finely-divided powder being substantially insoluble in the mixture of propellant and surface-active agent and, when said finely-divided powder is water-soluble, said composition containing not more than 300 parts per million of moisture, and which composition also comprises a minor amount of a higher alkyl (C10 to C20) chloride, bromide or iodide quaternary salt of pyridine or substituted pyridine.  The quaternary salt may be cetyl pyridinium chloride or bromide or myristylg -picolinium chloride.  The non-ionic surfactant may be the ester of a C6 to C22 fatty acid with a polyhydric alcohol or its anhydride, e.g. sorbitan mono-oleate, sesqui-oleate or tri-oleate. The powder to be sprayed may be a medicament, e.g. isoproterenol hydrochloride or sulphate, phenylephrine, phenylpropanolamine, glucagon, adrenochrome, trypsin, epinephrine, ephedrine, narcotine, codeine, atropine, morphine, dihydromorphine, ergotamine, pilocarpine, a  - (2 - dimethylaminoethyl) - o - chlorobenzhydiol, scopolamine, methapyrilene, cyanocobalamin, colchicine, neomycin, streptomycin, penicillin, procaine penicillin, tetracycline, chlorotetracycline, hydroxytetracycline, ACTH, cortisone, hydrocortisone, hydrocortisone acetate, prednisolone, or insulin; a cosmetic such as talc; an anti-perspirant such as aluminium chlorohydrate; a polishing material such as jeweller's rouge; a lubricant such as graphite, or a dye.  The propellant may be butane, pentane, methyl, ethyl or propyl chloride or a fluorinated or fluorochlorinated lower alkane or mixtures thereof. Additional solid may be added to increase the average specific gravity of the solid phase. Specification 837,465 is referred to.ALSO:A self-propelling powder-dispensing composition comprises a finely-divided powder suspended in a liquefied propellant having a vapour pressure of at least 13 lb. per square inch gauge at 70 DEG  F. and a liquid non-ionic surface-active agent having a hydrophilelipophile balance of less than 10 which surface-active agent is dissolved in said liquefied propellant, the said finely-divided powder being substantially insoluble in the mixture of propellant and surface active agent and, when said finely-divided powder is water-soluble, said composition containing not more than 300 parts per million of moisture, and which composition also comprises a minor amount of a higher alkyl (C10 to C20) chloride, bromide or iodide quaternary salt of pyridine or substituted pyridine.  The quaternary salt may be cetyl pyridinium chloride or bromide or myristyl-g -picolinium chloride.  The non-ionic surfactant may be the ester of a C6 to C22 fatty acid with a polyhydric alcohol or its anhydride, e.g. sorbitan monooleate, sesqui-oleate or tri-oleate. The powder to be sprayed may be a medicament e.g. isoproterenol hydrochloride or sulphate, phenylephrine, phenylpropanolamine, glucagon, adrenochrome, trypsin, epinephrine, ephedrine, narcotine, codeine, atropine, morphine, dihydromorphine, erogtamine, pilocarpine, a -(2 - dimethylaminoethyl) - o - chlorobenzhydrol, scopolamine, methapyrilene, cyanocobalamin, colchicine, neomycin, streptomycin, penicillin, procaine penicillin, tetracycline, chlorotetracycline, hydroxytetracycline, ACTH, cortisone, hydrocortisone, hydrocortisone acetate, prednisolone, or insulin; a cosmetic such as talc; an anti-perspirant such as aluminium chlorohydrate; a polishing material such as jewellers' rouge; a lubricant such as graphite, or a dye.  The propellant may be butane, pentane, methyl, ethyl or propyl chloride or a fluorinated or fluorochlorinated lower alkane or mixtures thereof.  Additional solid may be added to increase the average specific gravity of the solid phase.  Examples include mixtures of phenylephrine hydrochloride and isoproterenol sulphate; phenylephrine bitartrate and isoproterenol sulphate or hydrochloride; phenyl propanolamine hydrochloride and phenylephrine hydrochloride; phenylephrine bitartrate, isoproterenol hydrochloride and prednisolone acetate; and epinephrine bitartrate, atropine methyl nitrate, and papaverine hydrochloride.  Specification 837,465 is referred to.