baber/WOPTO huggingface dataset:
Patent NZ-731657-A (NZ)
Title: Composition for treating hyperlipidemia comprising oxyntomodulin derivative
Inventor: JUNG SUNG YOUB
IPC: A61P3/06
Filed: 2013-07-25
Abstract: The present invention relates to the use of an oxyntomodulin derivative conjugate in the preparation of a medicament for preventing or treating hyperlipidemia, fatty liver disease or atherosclerosis, wherein the oxyntomodulin derivative conjugate comprises; an oxyntomodulin derivative comprising the amino acid sequence of any one of SEQ ID NOs: 23, 27, 28, 32, 33, or 34, an immunoglobulin Fc region, and a non-peptidyl polymer, the non-peptidyl polymer comprising polyethylene glycol, polypropylene glycol, an ethylene glycol/propylene glycol copolymer, polyoxyethylated polyol, polyvinyl alcohol, polyvinyl ethyl ether, PLA (polylactic acid), PLGA (polylactic-glycolic acid), a lipid polymer, hyaluronic acid, or combinations thereof, and wherein the non-peptidyl polymer covalently links the oxyntomodulin derivative and the immunoglobulin Fc region; wherein the oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used in the manufacture of a medicament for the treatment of hyperlipidemia and related diseases.
Patent NZ-738553-A (NZ)
Title: Binding machine
Inventor: NAGAOKA TAKAHIRO
IPC: E04G21/12
Filed: 2016-07-21
Abstract: In conventional reinforcing bar binding machines, the wire binding the reinforcing bars has such a form that one end and the other end of the wire are directed to the side opposite to the reinforcing bars with regard to the reinforcing bars of the portion at which the reinforcing bars are bound by the wire. However, the wire binding the reinforcing bars has such a form that distal end portions of the wire are projected to be greater than a twisted region of the wire, and thus may interfere with work. The prior art discloses a technique for bending a distal end of a wire to a reinforcing bar side without projecting the distal end of the wire and a technique for bending an end of a wire in a twisting direction. However, how and in which direction the wire is bent is not disclosed. Therefore, even when the wire is made to be bent such that the end portions of the wire are located closer to a binding part than the top of the wire, a direction in which the wire is bent is not fixed in a desired direction, and the wire cannot be reliably bent such that the end portions of the wire are directed to the reinforcing bar side. The present invention provides a bending unit for bending wires such that end portions of the wires gripped by a gripping unit are located closer to a binding object than the top of the wire, and thereby the wire can be reliably bent. In particular, the present invention provides a binding machine comprising: a housing that is configured to house a wire; a wire feeding unit that is configured to feed the wire housed in the housing; a curl guide that is configured to wind the wire from the wire feeding unit in a loop around a binding object; a binding unit that includes a gripping unit which is configured to grip the wire and that is configured to twist the wire to bind the binding object; and a bending unit that is configured to bend the wire such that end portions of the wire which binds the binding object are located closer to the binding object than a top portion of the wire which protrudes the most in a direction away from the binding object, wherein the bending unit includes a fulcrum part which is a bending fulcrum when the wire is bent, and a bending part which bends the wire by using the fulcrum part as a fulcrum, the fulcrum part is provided on the gripping unit, and the bending unit bends the wire before the wire is twisted such that the end portions of the wire gripped by the gripping unit are located closer to the binding object than the top portion of the wire.
Patent NZ-742652-A (NZ)
Title: Refrigerator and air door device thereof
Inventor: ZHANG HUIMIN
IPC: F25D17/04
Filed: 2016-06-17
Abstract: Disclosed is a damper device (100) for a refrigerator (10) and a refrigerator (10). Wherein, the damper device (100) comprises: a door frame (110), which is provided with a vent (111); a door plate (120) , which is pivotally mounted on the door frame (110) to controllably adjust the opening area of the vent (111), the door plate (120) is provided on one side with a guide post (122), which is parallel to a pivot axis of the door plate (120) and extending outwardly; and a guide plate (130), which is translationally mounted on the door frame (110) and configured perpendicular to the pivot axis of the door plate (120). The guide plate (130) is provided with a guide recess (131) to be fitted with the guide post (122), and the extending direction of the guide recess (131) is configured at a predetermined angle with respect to the translation direction of the guide plate (130), to cause the guide post (122) to slide within the guide recess (131) when the guide plate (130) translates, so as to rotate the door plate (120) . The damper device of the refrigerator (10) has a simple structure, is easy to operate, and does not require consumption of electric power.
Patent NZ-752287-A (NZ)
Title: Production of re-188/186 particles
Inventor: NIKULA TUOMO
IPC: G21G1/06
Filed: 2017-10-10
Abstract: Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
Patent PT-100863-A (PT)
Inventor: CROSS PETER EDWARD
IPC: C07C323/56
Filed: 1992-09-11
Abstract: PCT No. PCT/EP92/02067 Sec. 371 Date Jul. 5, 1994 Sec. 102(e) Date Jul. 5, 1994 PCT Filed Sep. 3, 1992 PCT Pub. No. WO93/06098 PCT Pub. Date Apr. 1, 1993   <IMAGE>  (I)   <IMAGE>  (Ya)   <IMAGE>  (Yb)  Compounds of formula (I) wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy or (b) a thienyl group; and Y is of formula (Ya) or (Yb) where A and B are 0, 1 or 2, D and E are 0 or 1, F is 0-3 and D+E+F=1-3, Z is 0, 1 or 2, R1 and R2 are H or alkyl or form a ring, and R3 is C1-C4 alkyl, C3-C6 cycloalkyl or optionally substituted phenyl or benzyl, are antimuscarinic bronchodilators useful for treating chronic obstructive airways disease or asthma.
Patent PT-104158-A (PT)
Title: Aplicação da monooleína como novo lípido adjuvante em lipofecção
Inventor: CASAL MARGARIDA PAULA PEDRA AM
IPC: C12N15/88
Filed: 2008-08-18
Abstract: A PRESENTE INVENÇÃO DIZ RESPEITO À APLICAÇÃO DE SISTEMAS LÍPIDICOS CATIÔNICOS À BASE DE MONOOLEINA, NA COMPLEXAÇÃO, TRANSPORTE E TRANSFECÇÃO DE MATERIAL GENÉTICO EM CÉLULAS ALVO. OS SISTEMAS LIPÍDÍCOS SÃO PREPARADOS ATRAVÉS DA CONJUGAÇÃO DO LÍPIDO NEUTRAL MONOOLEOÍL-RAC-GLÍCEROL (MONOOLEINA) COM OS TENSIOACTIVOS CATIÁNÍCOS DA FAMÍLIA DE DIOCTADECILDÍMETÍLAMÓNIO (DODAX) (BROMETO DE DIOCTADECILDIMETILAMÓNIO (DODAB), CLORETO DE DIOCTADECILDÍMETILAMÓNIO (DODAC) E FOSFATO DE DIOCTADECILDÍMETILAMÓNIO (DODAP)) . ESTE MÉTODO DE LÍPOFECÇÃO É APLICÁVEL TANTO NO DOMÍNIO DA INVESTIGAÇÃO EM BIOLOGIA MOLECULAR (APLICAÇÃO IN VITRO), COMO NA ÁREA DASAÚDE EM TERAPIA GÉNICA (APLICAÇÃO IN VIVO), APRESENTANDO ELEVADOS NÍVEIS DE BIOCOMPATIBÍLÍDADE E REDUZIDOS CUSTOS DE AQUISIÇÃO.
Patent PT-105368-A (PT)
Title: Tanque flutuante assimétrico conversor de energia das ondas
Inventor: SILVA SERGIO BRUNO NOGUEIRA RIBEIRO E
IPC: F03B13/00
Filed: 2010-11-08
Abstract: O PRESENTE INVENTO DIZ RESPEITO A UM TANQUE FLUTUANTE ASSIMÉTRICO CONVERSOR DA ENERGIA DAS ONDAS EM ENERGIA ELÉCTRICA, COM UM SISTEMA DE AMARRAÇÃO AO FUNDO DO MAR, ESTANQUE EM RELAÇÃO AO EXTERIOR. O ARRANJO INTERIOR É DEFINIDO POR DOIS RESERVATÓRIOS VERTICAIS (1), QUE SE LIGAM ENTRE SI NAS PARTES INFERIOR E SUPERIOR POR DUAS CONDUTAS HORIZONTAIS. ENTRE OS DOIS RESERVATÓRIOS DO TANQUE, MOVIMENTAM-SE CONTINUAMENTE DOIS FLUIDOS, UM NO ESTADO LÍQUIDO E O OUTRO NO ESTADO GASOSO (QUE PODEM SER ÁGUA E AR), SENDO OS MOVIMENTOS DO SISTEMA INDUZIDOS PELAS ONDAS INCIDENTES. DENTRO DA CONDUTA SUPERIOR (2) EXISTE UMA TURBINA AXIAL E REVERSÍVEL, ACCIONADA PELO MOVIMENTO DO GÁS QUE ATRAVESSA A CONDUTA SUPERIOR, GÁS ESSE QUE SE MOVIMENTA DEVIDO À DIFERENÇA DE PRESSÕES SOBRE SI EXERCIDA PELO LÍQUIDO, QUE SE MOVIMENTA DEVIDO AOS MOVIMENTOS OSCILATÓRIOS DO FLUTUADOR PROVOCADOS PELAS ONDAS DO MAR (3), NOMEADAMENTE A DERIVA, A ARFAGEM E O BALANÇO.
Patent PT-107829-A (PT)
Title: Asa de geometria variável contínua
Inventor: REIS ANTÓNIO JOÃO FERREIRA
IPC: B64C3/48
Filed: 2014-08-06
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM CONJUNTO DE DISPOSITIVOS INTERDEPENDENTES QUE PERMITEM A ALTERAÇÃO DA CURVATURA DO PERFIL DE UMA ASA, DE MODO A QUE A SUA SUPERFÍCIE PERMANEÇA SEMPRE CONTÍNUA E SUAVE. É COMPOSTO POR UM DISPOSITIVO COMBINADO DE ARTICULAÇÕES INSTALADAS NUM DADO NÚMERO DE PARES DE PERFIS (1,2) ENTRELAÇADOS, E QUE É ACTUADO POR UM SERVO-MOTOR (17) . CADA PAR DE PERFIS É SUPORTADO POR UMA DUPLA ARTICULAÇÃO INFERIOR (6, 6A, 6B) QUE PERMITE A SUA ROTAÇÃO EM RELAÇÃO ÀS LONGARINAS (3), EM TORNO DA LINHA DA CORDA DO PERFIL E POR UMA ARTICULAÇÃO SUPERIOR (14) QUE PERMITE A SINCRONIZAÇÃO ENTRE DIFERENTES PARES DE PERFIS E É COMANDADA PELO SERVO-MOTOR. A VARIAÇÃO DA GEOMETRIA DA SUPERFÍCIE AERODINÂMICA TEM COMO LIMITES A FORMA CORRESPONDENTE A CADA UM DOS PERFIS ENTRELAÇADOS. A INVENÇÃO É TAMBÉM COMPOSTA POR UM REVESTIMENTO, ONDE UMA TELA IMPERMEÁVEL (21) É MANTIDA TENSIONADA PELA PONTA DE ASA (7), SUPERFÍCIE DE BORDO DE FUGA (8), SUPERFÍCIE DE BORDO DE ATAQUE (9) E AJUSTADOR (20). A PRESENTE INVENÇÃO É APLICÁVEL AO FABRICO DE UMA SUPERFÍCIE AERODINÂMICA DE GEOMETRIA VARIÁVEL CONTÍNUA.
Patent PT-108567-A (PT)
Title: Processo de soldadura por fricção com ferramenta rotativa
Inventor: DULCE MARIA ESTEVES RODRIGUES
IPC: B23K20/12
Filed: 2015-06-22
Abstract: TRATA-SE DE UMA TÉCNICA DE SOLDADURA EM ESTADO SÓLIDO, QUE ASSENTA NA UTILIZAÇÃO DE UMA FERRAMENTA (1) CILÍNDRICA SUJEITA A UMA FORÇA AXIAL E ANIMADA, EM SIMULTÂNEO, DE MOVIMENTOS DE ROTAÇÃO (X) E TRANSLAÇÃO (Y) PARA PROMOVER A LIGAÇÃO POR SOLDADURA (4) ENTRE UM METAL DE BASE (2) E OUTRO METAL DE BASE (3). O CALOR GERADO É TRANSMITIDO POR CONDUÇÃO AOS ELEMENTOS A LIGAR, QUE SOFREM AMACIAMENTO E DEFORMAÇÃO PLÁSTICA EM COMPRESSÃO, SOB ACÇÃO DA PRESSÃO AXIAL DE FORJAMENTO APLICADA PELA FERRAMENTA (1) EM ROTAÇÃO (X). ATRAVÉS DE UMA SELEÇÃO PONDERADA DO DIÂMETRO DA FERRAMENTA, DA FORÇA AXIAL E DAS VELOCIDADES DE ROTAÇÃO E DE TRANSLAÇÃO, O PROCESSO DESENVOLVIDO PERMITE EFECTUAR LIGAÇÕES CONTÍNUAS, POR SOLDADURA (4) EM ESTADO SÓLIDO, ENTRE COMPONENTES DAS MAIS DIVERSAS GEOMETRIAS.
Patent RO-84866-A (RO)
Inventor: BOUTONNAT MAURICE
IPC: E21F17/18
Filed: 1982-12-14
Abstract: A process of remote transmission of signals issued by at least one sensor over a transmission line, wherein the power necessary to supply the sensor is transmitted by that line in the form of an alternating current signal of approximately constant intensity, and wherein the line fulfills the triple function of supplying power to that sensor, of transmitting interrogation signals from a central station to that sensor and of transmitting data signals in response to that interrogation signal from the sensor to the central station. A device for incorporating this process is also disclosed.
Patent RU-94012368-A (RU)
Inventor: TSYGULEV I N
IPC: H02H3/08
Filed: 1994-04-07
Abstract: FIELD: electric engineering. SUBSTANCE: device has current-to-voltage converter, predicting and delay circuits, comparator, memory unit. Device may be used for design of input circuits of relay protection devices in order to achieve orthogonal signals. EFFECT: decreased error in prediction of signals having arbitrary shape.
Patent RU-94015931-A (RU)
Inventor: PAVLOV A O
IPC: A61B5/16
Filed: 1994-05-17
Abstract: FIELD: medicine. SUBSTANCE: method involves creating a set of additional information sheets for testes after their being given primary registry cards. Personality ambition index value is taken into account. All sheets are divided into subset of personal information sheets, subset of freely distributed information sheets, information sheets subset of limited distribution, and a set of additional information sheets having variable significance value. All additional information sheets are randomly distributed over the distribution sites where consulting operator is placed that follows the rules and controlling procedures of sheet-to-sheet exchange during short time intervals. EFFECT: enhanced accuracy of tests.
Patent RU-94021096-A (RU)
Inventor: PEREL SHTEJN P V
IPC: D06F75/00
Filed: 1994-06-06
Abstract: FIELD: household appliances. SUBSTANCE: main drawbacks of electric irons are: danger of electric shock, fire hazard if iron is left unattended for long time, non-rational consumption of electric energy. Offered iron has no such drawbacks. Used in non-heated iron are ball bearings, balls of which serve as working surface of iron. Balls are arranged in open cases and are free to move in direction of iron movement, thus ironing the cloth. EFFECT: enhanced safety, reliability and convenience.
Patent RU-94022914-A (RU)
Inventor: TOLSTOJ V S
IPC: A61N1/16
Filed: 1994-06-29
Abstract: FIELD: medicinal equipment. SUBSTANCE: device consists of a number of forming elements connected with a bottom and divided by grooves connected with central cavity in which additional forming element is situated along its axis. Forming element could be of any shape: sphere, cylinder, polyhedron, cone or frustrum. Additional forming element has tubers and trenches on its surface that are randomly oriented. At least some part of element's surface should have covering distinct according to reflecting or absorbing capacities. At least one wall of every groove crosses lateral surface of central cavity at an angle providing eddy direction of reflected energy. EFFECT: higher efficiency.
Patent RU-94023004-A (RU)
Inventor: PETROV B JU
IPC: B01F3/08
Filed: 1994-06-15
Abstract: FIELD: method of burning fuel oil in boiler units and preparation of water-and-fuel oil emulsion. SUBSTANCE: method provides for improvement of storage, preparation and supply of fuel oil for burning in boiler unit through emulsifying fuel oil with water at all stages of preparation of fuel oil for burning and in entire volume of fuel oil loaded in reservoirs. Method includes storage, preparation and supply of fuel oil. Supply of fuel oil consists in loading the fuel oil in reservoirs, maintaining temperature in reservoirs from 40 to 140 C by means of cyclic pumping of fuel oil through heaters and emulsifying of fuel oil in feeding it from reservoirs into boiler units for burning; fuel oil is subjected to additional emulsifying in loading it in reservoirs, as well as during storage of it in reservoirs at temperature of from 40 to 140 C; emulsification is effected at each of three stages with water either available in it or fed from outside. EFFECT: prevention of free water from getting on burners of boiler units, thus excluding formation of drains contaminated with fuel oil; reduction of discharge of nitrogen oxides, benzpyrene and sooty sediments into atmosphere.
Patent RU-94024917-A (RU)
Inventor: NEFED EV V I
IPC: G03B17/56
Filed: 1994-07-01
Abstract: FIELD: photography, design of small-sized table tripods. SUBSTANCE: tripod has two supports which ends are bent to opposite sides, center support is straight with hole or groove for clamping screw and platform of threaded connection with camera on top. Needed working height of stand or stability can be obtained by change of angular position of supports. There is sufficient range of smooth change of angular positions of supports. Usage of tripod without tripod head is possible. Parts of tripod are simple to manufacture. Tripod is convenient in work and portable. EFFECT: expanded functional capabilities of tripod by provision for smooth change of working weight of it.
Patent RU-94026059-A (RU)
Title: Crawler belt vehicle on air cushion
Inventor: STROBYKIN O V
IPC: B60B19/00
Filed: 1994-07-15
Abstract: FIELD: transport engineering; cross-country vehicle on wheels, crawler belts and air cushions. SUBSTANCE: known cross-country vehicles on metal tracks are heavy-weight machines which limit their cross-country capacity and versatility. Known air-cushion vehicles are small-weight machines featuring high cross country capacity only on flat terrain. There are also vehicles with crawler belts designed specially for moving on water. Purpose of invention is creation of vehicle with no drawbacks indicated above and suitable for movement over water, snow, ice-covered surfaces and rough terrain. This purpose is achieved by forming air cushion under vehicle bottom by fans, with vehicle resting on side flexible crawler belts which seal air cushion. Driving and driven wheels of crawler belt are made with little number of flats, for instance, three, to increase pull force. Made on outer portion of belt is tread of strips which can be laid on prism flats in whole numbers, for instance 9 to 12. Grousers are made on these prisms. Made on inner side of belt are tracks of antifriction coating under ski. Rollers between driven and driving wheels are equal in height to track of flexible wheels. Placed between rollers are skis coated with antifriction materials. Secured on skis are flexible screens sealing side surface of pan. Nose and rear portions of bottom are sealed by rotating wheels of higher flexibility, each equal to half the bottom width. Higher flexibility rotating wheels are made on common shafts combined with working and driving wheels in front of track and with driven wheel at the rear. Working wheel is located outside close to track on common shaft with driving wheel. Rotary internal combustion engine is made inside wheel. Flexible tread of higher heat resistance is fitted outside wheel. Flexible screens are made close to sealing wheels in front and rear parts of vehicle. Screens are secured by bottoms to strip, close and parallel connected at wheel edge. Track middle portion is protected from overloading in vehicle gravity center by working wheel secured in suspension, with internal combustion engine inside, on common shaft with roller inside track. Made on top of track is roller holding track tensioned when lifting front and rear portions of track belt by pneumatic cylinder lifts used also as track belt shock absorbers. Made outside crawler belt portion of vehicle along vehicle gravity center in front and rear are working wheels, with rotary engines inside, used as steering wheels which are furnished with pneumatic cylinder lifts used simultaneously as shock absorbers and central steering rod of steering wheel. Lifts of front and rear steering wheels can be used to step over edges of soil or ice flow to prevent tipping over of falling down of soil. Offered is light-weight wheel of higher thermal stability made of twisted leaf radial springs connected by bundle of heat resistant threads and protector rings. EFFECT: increased cross-country capacity of vehicle. 6 cl, 5 dwg
Patent RU-94030029-A (RU)
Inventor: EHJRISH M V
IPC: C04B33/13
Filed: 1994-08-09
Abstract: FIELD: production of composite materials. SUBSTANCE: raw materials mixture which contains graphite and easily fusible clay (their quantities being 5-30 and 70-95 mass % respectively) is used for production of conducting material. Thus obtained articles are roasted at 600-800 C by limited access of air. Specific resistance of desired material is 1,8•10-4•10onm•m.. EFFECT: improves efficiency of the method. 4 tbl
Patent RU-94030066-A (RU)
Inventor: SEMENOV V A
IPC: C10C3/04
Filed: 1994-08-05
Abstract: FIELD: production of road-building materials from oil remains. SUBSTANCE: apparatus has cylindrical vertical casing with vertical internal wall positioned in spaced relation with respect to casing cover and bottom for allowing free flow of product from one section to the other section. Apparatus is further provided with branch pipes for charging raw material and branch pipes for discharging ready product, bubbling device for supplying oxidizer and heater positioned in lower part of casing. Inner cavity of reactor is divided by radial vertical walls into three equal volume sections and is further provided with additional vertical walls defining chords connecting apexes of radial walls. Heaters and bubblers are positioned at both sides of each section. EFFECT: increased efficiency by intensified oxidation process and reduced power consumption for production of bitumen.
Patent RU-94031434-A (RU)
Inventor: SHISHKOV V V
IPC: C02F103/44
Filed: 1994-09-05
Abstract: FIELD: waste water treatment. SUBSTANCE: invention relates to waste waters containing petroleum derivatives and suspended substances and may be used for treating waste water from washing of motor cars, rail-way transport, etc. Plant is distinguished with that preliminary settling chamber 7 is connected with admission tank 1 through hydrocyclone 6 and with posttreatment chamber 14 through oil-intake arrangement 10 and pipeline 12, which leads liquid to posttreatment chamber filter. Chamber 7 encloses partition 9 and plates 8 mounted from both sides of partition at angle 30-45 deg. in regard to side walls, whereas partition 9 is made in the form of broken line and distance between bottom of chamber and partition with plates is 1/50 chamber height. EFFECT: enhanced efficiency of treatment and reduced treatment time.
Patent RU-94033295-A (RU)
IPC: B29C67/04
Filed: 1994-09-12
Abstract: FIELD: polymeric materials. SUBSTANCE: powder-like vinyl chloride polymer is formed as a layer on backing using roller. Layer is subjected for caking and frothing by heating with both sites using infra-red radiation up to the apparent density 0.25-0.70 g/cm.. EFFECT: improved method of material making.
Patent RU-94037015-A (RU)
Inventor: SIMONOV JU A
IPC: C01G25/06
Filed: 1994-10-24
Abstract: FIELD: production of inorganic chemicals. SUBSTANCE: method includes treatment of baddelite with hydrofluoric acid in presence of sulfuric acid and deposition of zirconium sulfate from filtered solution with concentrated sulfuric acid, the two operations being conducted in a specified operation regime enabling considerable reduction in acids' input, essential elimination of water consumption, increased output, and maximal utilization of solid and liquid worked out products. Maximal technical and economic effect may be achieved when applying this method at enterprises producing hydrofluoric acid through sulfuric acid decomposition of fluorite. EFFECT: enhanced efficiency of process. 5 cl
Patent RU-94042466-A (RU)
Title: Pharmaceutically active bicyclic heterocyclic amines
Inventor: DONAL D I EHJIR
IPC: A61P25/28
Filed: 1993-03-16
Abstract: FIELD: organic chemistry. SUBSTANCE: product: bicyclic heterocyclic amines of the formula (XXX)where W- group -N= or -CH=; W- group -N= or -CH=; W- group -N= or -CR- at condition that W- group -CR- when Wand Wis simultaneously group -N=. Compounds were used as drugs for treatment of light and/or from moderate to severe head trauma, subarachnoid bleeding and the following ischemic shock, asthma and decreased mucus formation/secretion in lung and other diseases and damages. EFFECT: improved method of synthesis, enhanced effectiveness of treatment.