baber/WOPTO huggingface dataset:
Patent RU-2762356-C2 (RU)
Title: REAGENT SET FOR ESTIMATING EFFICIENCY OF THERAPY WITH TYROSINE KINASE INHIBITORS AT Ph-POSITIVE NEOPLASMS AND ITS APPLICATION METHOD
Inventor: KOMINA ANNA VLADIMIROVNA
IPC: C12Q1/68
Filed: 2020-06-19
Granted: 2021-12-20
Abstract: FIELD: molecular biology; biotechnology; medicine. 
     SUBSTANCE: invention relates to molecular biology, biotechnology and medicine, in particular to hematology, oncology; it can be used for the estimation of the efficiency of the therapy of Ph-positive oncohematological diseases. A set for a multiplex PCR analysis of an expression level of chimeric RNA molecules with simultaneous detection of mutations of resistance to tyrosine kinase inhibitor (hereinafter – TKI) therapy, as well as an accelerated and economical method for the diagnostics of Ph-positive oncohematological diseases based on it, contains a buffer solution, deoxynucleotide triphosphates, specific primers, TaqMan probes, Taq-polymerase, MgCI 2  and water in optimal ratios providing an optimal enzyme work. A method for the estimation of the efficiency of the therapy with tyrosine kinase inhibitors at Ph-positive neoplasms using the claimed set also includes the amplification in the following temperature mode: preliminary denaturation – 95°C – 5 minutes; 50 reaction cycles in the mode of 95°C – 15 s, 60°C – 40 s. A quantitative assessment of a chimeric DNA fraction is calculated based on values of threshold Ct cycles in amplification reactions of BCR-ABL1 and ABL1 fragments, where a number of ABL1 copies is calculated according to the formula: IS(%)=(N(BCR-ABL1)/N(ABL1))·1.265·100. when BCR-ABL1 level of more than 1% is determined, it is concluded that a patient has resistance to used TKI preparations. In the case if simultaneously detected difference of values of Ct (mutation under study) and Ct (ABL1) for any of detected mutations is less than the set critical threshold, it is concluded that the detected mutation or mutation combination is a cause of this resistance. 
     EFFECT: manufacture of the reagent set for multiplex PCR in real time, allowing, in one analytical setting, for quantitative assessment of the level of chimeric BCR-ABL1 transcript in the blood sample, as well as detection of 8 mutations of TKI resistance – G250E, Y253H, E244K, E255V, T315I, F317L, F359I, F359V – for the estimation of the therapy efficiency, which allows, while reducing research time and material costs, for obtaining more complete information about the disease course. 
     2 cl, 9 tbl, 4 dwg, 3 ex
Patent UA-62995-C2 (UA)
Title: A process for preparing an aqueous hydrogen peroxide solution directly from hydrogen and oxygen, and a device for implementing thereof
IPC: B01J12/00
Filed: 1999-01-29
Abstract: The invention concerns a catalytic process and a device for preparing, in absolute safety, aqueous hydrogen peroxide solutions at high concentration levels directly from hydrogen and oxygen. More particularly, it concerns a method whereby hydrogen and oxygen are injected, into the aqueous medium in proportions corresponding to the flammability range of the hydrogen-oxygen mixture, and are present in proportions outside the flammability range in the continuous gas phase. The invention also concerns a device for implementing said method.
Patent UA-63033-C2 (UA)
Title: Strain gage force transducer
Inventor: NIKITINSKYI MYKHAILO PAVLOVYCH
IPC: G01L1/22
Filed: 2001-10-11
Abstract: The proposed strain gage force transducer can be used in various weighing devices. The transducer contains a cylindrical casing, in which a restoring sensitive element with strain gages is installed. The end surface of the sensitive element is in contact with the lower end surface of a cylindrical support element coupled with the casing by a thread connection. In the central opening of the sensitive element, a force-transmitting rod is installed. The lower end surface of the force-transmitting rod has a projection, which surface is in contract with the lower internal surface of the sensitive element. To the lower part of the casing, a cover is fitted that has a stop that is in contact with the lower end part of the force-transmitting rod. The position of the cover relative to the casing can be adjusted. Additionally, at the lower part of the casing, an opening is provided that is designed for fitting a suspended load-bearing plate. The proposed transducer senses the tension force caused by the load action on the suspended load-bearing plate and provides the conversion of the said tension force into the compression force acting on the sensitive element. As a result, it is possible to use measuring devices with reference force-setting elements when testing the transducer and test various transducers while using the same base support surfaces.
Patent UA-71962-C2 (UA)
Title: Halo derivatives of 9-deoxo-9a-aza-9a-homoerythromycin a, a method for the preparation thereof and a pharmaceutical composition
IPC: A61K31/70
Filed: 2000-05-02
Abstract: The invention relates to halo derivatives of 9a-N-(N'-arylcarbamoyl)- and 9a-N-(N'-arylthiocarbamoyl) -9- de-oxo-9a-aza-9a-homoerythromycin A of general formula (I) wherein R has the meaning of a substituted aryl group of formula (II) wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a (C1-C6)haloalkyl or a (C1-C6)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen, halo, a (C1-C6)alkyl or a (C1-C6)alkoxy group, and   has the meaning of oxygen or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for the preparation, of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.
Patent UA-78379-C2 (UA)
Title: Driving gear of cutter-bar of reaper
Inventor: AHAPOV MYKOLA DMYTROVYCH
IPC: A01D34/00
Filed: 2005-04-12
Abstract: A driving gear of a cutter-bar of a reaper is proposed. It contains a piston rod, connected to one of the arms of a double-arm lever, which is arranged on the axle between the upper mould board and the lower one of a rail and is made in such a manner as to allow rotating around it, the head of a knife connected with the second arm of the double-arm lever. The piston rod is connected with one of the arms of the double-arm lever by means of spherical bearings, and the axle of the lever is made in such a manner as to allow moving thereof both along axle thereof and in perpendicular thereto, and the head of the knife is connected to the second arm of the lever directly by means of a resilient element.
Patent UA-79648-C2 (UA)
Title: Non-woven fiber material
Inventor: PAKHARENKO VALERII OLEKSANDROV
IPC: D04H1/46
Filed: 2005-05-27
Abstract: Non-woven fiber material includes mix of synthetic composite fiber of polypropylene in mix with co-polymer of ethylene and vinyl-acetate and wool fiber - waste of cattle wool formed into pack.
Patent UA-79688-C2 (UA)
Title: Method for production of high-quality steel and technological line for realization the same
Inventor: BODROV VOLODYMYR VIKTOROVYCH
IPC: C21C5/52
Filed: 2005-09-30
Abstract: The invention relates to the field of ferrous metallurgy. A method for production of high-quality steel involves obtaining of the partly reduced iron-bearing material by magnetic separation at the temperature of superfine magnetite ore of 520 - 570 DEGREE C with subsequent reducing thereof, its supplying into the charge of the electric arc furnace, charge melting, transfusion of the melt from the electric arc furnace into the first induction-arc furnace, into which deoxidizers and ferroalloys more electropositive than iron are supplied, in a quantity according to the prescribed chemical composition of steel, transfusion of the melt into the second induction furnace, where other alloying ferroalloys are supplied, with the subsequent pouring of the obtained steel. Besides, the technological line for method realization is claimed. The invention allows to obtain high quality steel.
Patent UA-82556-C2 (UA)
Title: Method for production of hot-rolled seamless tubes from titanium-based alloys
Inventor: TRYHUB MYKOLA PETROVYCH
IPC: B21B3/00
Filed: 2006-04-07
Abstract: The invention relates to the tube rolling production, namely to the production of hot-rolled seamless tubes from titanium-based alloys. A method for production of hot-rolled seamless tubes from titanium-based alloys includes heating the billet before deformation to set temperature, piercing of heated billet on the mill of cross-helical rolling and rolling of pierced billet into the pipe on reeling machine and sizing mill. Novelty of the method consists in that the pipe is manufactured from cast undeformed billet, preheating of which is performed to the temperature, which is by 2… 5% lower than lower temperatures of β-region of the phase diagram of alloy. Piercing of billet is performed with ovalization coefficient of 1.075… 1.09, rolling is performed with deformation degree of 30% on the wall of pierced rough tube, and the rolling is terminated at a temperature, which corresponds to α-region of the phase diagram of alloy. The application of the method will make it possible to obtain high-quality hot-rolled seamless tubes from titanium-based alloys.
Patent UA-80370-C2 (UA)
Title: Fungicidal mixture, agent, method for control, seed and use of compounds
Inventor: TORMO I BLASCO
IPC: A01N59/26
Filed: 2004-11-18
Abstract: The invention relates to fungicidal mixtures for controlling rice pathogens, which comprise as the active components 1) the triazolopyrimidine derivative of formula (I) and 2) phosphorous acid H3PO3, the alkali or alkaline earth salts thereof or derivatives releasing the same in a synergistically effective amount. The invention also relates to a method for controlling parasitic fungi using mixtures of compound I with compound II and to the use of compound I with compound II for producing the aforementioned mixtures, and to agents that contain said mixtures. (I)
Patent UA-82159-C2 (UA)
Title: Method for preparation of aqueous alcoholic infusion of cereals grains for manufacturing of alcoholic beverages
Inventor: ZLOTNYTSKYI VIKTOR VASYLIOVYCH
IPC: C12G3/08
Filed: 2006-12-06
Abstract: A method for preparation of aqueous alcoholic infusion of cereals grains for manufacturing of alcoholic beverages provides for the washing of starting material with water and separation of aqueous phase. Washed grains are treated with water for 1.5-2.5 hours. Then water is decanted, and the material is covered with the wet tissue for 2-3 hours. The sprouts are infused in water-ethanol mixture (45% of ethanol) for 4-5 days at the 1:10 – 0.1:0.7 ratio followed by filtration of infusion obtained. The invention provides for imparting the slight scent of the walnut and the acacia pods to vodka with the maximal preservation of the useful biologically active substances of the sprouts.
Patent UA-85600-C2 (UA)
Title: Method for producing microspheres, in particular those, which are formed within composition of fly ash during combustion of coal
Inventor: SKVARCHYNSKYI VIKTOR IVANOVYCH
IPC: B03B5/64
Filed: 2007-01-25
Abstract: The invention relates to producing microspheres, which are formed within the composition of the fly ash during combustion of coal. A method includes hydro-separation of aqueous suspension of fly ash, drying and isolation of microspheres. In accordance with the invention, the hydro-separation is performed by means of a pump, which is dipped at angle into the container, which contains the aqueous suspension of fly ash. The pump contains two stages, the first stage is in the form of a set of jets, by which the compressed air is directed into the container and the layer of concentrated suspension of fly ash is isolated, and the second stage, which is an injector pump, by which the selected concentrated suspension of fly ash is transported to a dryer, in which the moisture is evaporated. The produced microspheres are transported to an accumulator with their subsequent shipment. Due to the application of new equipment and operations the layer of concentrated suspension of fly ash can be isolated and processed, that leads to increase of the efficiency of method.
Patent UA-94212-C2 (UA)
Title: Method and device for enhancing process involving solid object and gas
Inventor: KREBS NIELS
IPC: F28F13/10
Filed: 2005-08-15
Abstract: This invention relates to a sonic device (and a method) for enhancing a process involving a solid object and a gas, where the gas surrounds the object or at least is in contact with a surface of the object, the device comprising sonic means for applying a high intensity sound or ultrasound to at least the surface of the object, wherein the high intensity sound or ultrasound, during use of the sonic device, is applied directly in the gas that is also the medium through which the high intensity sound or ultrasound propagates to the surface of the object, whereby a laminar sub-layer at the surface of the object is reduced and/or minimized. The reduction of the laminar sub-layer provides increased heat transfer efficiency and/or increased catalytic speed and/or increased gas exchange.
Patent UA-85517-C2 (UA)
Title: Boiler unit
Inventor: BRYKAILO ROMAN VOLODYMYROVYCH
IPC: F23L15/00
Filed: 2007-03-27
Abstract: The invention relates to heat power engineering, in particular – to device for protection of surfaces of heating of boiler installations against corrosion at idling. Boiler unit has at one side connected in parallel to steam-water circuit water economizer and screen system with draining lines, tank for draining water, this is connected with pipeline to draining pump, barrel, superheater, at its output pipeline is installed with shutoff fittings, it is connected to degasser through pipeline with shutoff fittings, and at the other side – connected to gas circuit furnace, convective shaft output of which is with gas duct that connects to each other installed in sequence recuperative air heater, shutoff fittings, smoke duct connected to smoke pipe/ At that it in addition includes pipeline with shutoff and control fittings, that is included between draining lines of water economizer, screen system and tank for draining water. The invention makes it possible to heat to needed temperature deposits on outer heating surfaces for evaporation of aggressive components and to remove those out of boundaries of boiler unit and thus to protect outer heating surfaces against corrosion at idling.
Patent UA-92331-C2 (UA)
Title: Accessory box of airplane engine such as jet engine
Inventor: ABOUSLEIMAN VINCENT
IPC: F02C7/06
Filed: 2007-05-17
Abstract: An airplane engine accessory box carrying an electrical machine (16) such as an alternator, having a rotor (14) that is guided in rotation in a bearing (24) carried by a support (40) part made of a material having a low coefficient of thermal expansion, itself carried by a stator cover (42) that acts as a heat bridge between the body (20) of the stator of the electrical machine and the casing (10) of the accessory box.
Patent UA-89220-C2 (UA)
Title: Method for treatment of hiv/aids by administration of solid pharmaceutical dosage formulation comprising a hiv protease inhibitor in fasted state
Inventor: ROSENBERG JOEERG
IPC: A61K9/20
Filed: 2006-02-21
Abstract: The present invention provides a pharmaceutical dosage formulation, and more particularly, to a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
Patent UA-94907-C2 (UA)
Title: Device and method for admixing liquids into flowable bulk material
Inventor: ETZENBACH JOACHIM
IPC: B05B7/12
Filed: 2007-12-13
Abstract: A device for admixing a liquid into flowable dry materials, preferably into dough for making liquid dough, has a housing with a mixing chamber having an inner wall with an impact area and an exit opening at a bottom end of the mixing chamber. Dry material is supplied from above into the mixing chamber and falls downwardly toward the impact area in front of the inner wall of the mixing chamber and exits through the exit opening. A nozzle generates a pressurized high-speed jet of a liquid impacting on the inner wall of the mixing chamber in the impact area and wetting the dry material with the liquid as the jet passes through the dry material and impacts against the inner wall. An opening inside the housing is provided for supplying liquid and pasty additives, wherein the opening is directed toward an area of the mixing chamber between the nozzle and the impact area.
Patent UA-86724-C2 (UA)
Title: installation for measuring structural and mechanical properties of alloys
Inventor: NAIDEK VOLODYMYR LEONTIOVYCH
IPC: B01L99/00
Filed: 2008-05-27
Abstract: The invention relates to the foundry engineering and concerns installation for measuring the structural and mechanical properties of alloys. An installation includes a melting furnace with a crucible, a corrugated plate with a stock, which is installed into a guiding bush from heat-conducting material, which is not moistened by the melt, a balanced system of loading and a recorder. The crucible is fixed on the platform with a vertical shaft of rotation, which is connected with an electric drive through the bottom in the heating furnace. Technical result: increase of the accuracy of measurement of structural and mechanical properties of alloys in liquid-solid state with breakable structure.
Patent UA-92254-C2 (UA)
Title: Autonomous device for excavators travel motion
Inventor: MALYSHEV VALERII VASYLIOVYCH
IPC: B60L11/00
Filed: 2009-03-16
Abstract: The invention relates to mining industry. Device for travel motion of excavator includes control panel connected to control system of energy supply device. The last one is electrically connected to armature converters of propel motors of excavator and devices for dynamic deceleration of propel motors and also to power converters of excitation windings of propel motors and source of power supply of braking devices of caterpillars. There are provided as well main generator, supplementary generator that is electrically connected to accumulator and is arranged with possibility of charging, power drive and protective device for phase-to-phase faults. The last one is electrically connected to main generator and is arranged with possibility of power supply of said armature converters of propel motors, devices for dynamic deceleration of propel motors and power converters of excitation windings of propel motors and power supply source of braking devices of caterpillars. Technical result is in possibility of displacement of excavator independently from main high-voltage circuit.
Patent UA-102063-C2 (UA)
Title: Soyabean plant producing arachidonic acid
Inventor: DAMUDE HOWARD G
IPC: A23L25/00
Filed: 2008-02-12
Abstract: Oilseed plants which have been transformed to produce arachidonic acid, recombinant constructs used in such transformations, methods for producing arachidonic acid in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Patent UA-88858-C2 (UA)
Title: process of micro-encapsulation of hydrocarbons
Inventor: SERDIUK VITALII OLEKSANDROVYCH
IPC: A61K9/50
Filed: 2009-07-13
Abstract: The invention concerns the field of colloid chemistry, namely producing the polymeric filled micro-capsules. A process of micro-encapsulation of hydrocarbons includes preparation of a solution of encapsulating polymer and hydrocarbon in organic solvent, preparation of an aqueous solution of stabilizer, mixing and dispersion of the solutions, extraction of organic solvent with simultaneous producing micro-capsules with encapsulation by hydrocarbon, filtration and drying thereof under the room temperature and atmospheric pressure. An organic solvent is added to the aqueous solution of stabilizer, and after dispersion water is added. As hydrocarbons it is expedient to use individual liquid or solid hydrocarbons under standard conditions, or mixtures thereof. As encapsulating polymers it is expedient to use heterofunctional copolymer of general formula:
Patent UA-93811-C2 (UA)
Title: Method for producing of diffusion borated coating on working surfaces of details of machines
Inventor: STETSKO ANDRII YEVHENOVYCH
IPC: C23C10/02
Filed: 2010-02-18
Abstract: A method for producing of diffusion borated coating on working surfaces of machine details relates to mechanical engineering. A method comprises the application of envelope on surface of detail for chemical-heat-treatment - diffusion borated at the heating by high-frequency currents. The envelope contains boron carbide and solution of glue BF in acetone as binding agent in envelope, and also iron oxide, chark and activating agent – sodium fluoride. The invention provides to produce of strengthened layer having thickness of and microhardness of 10 GPa.
Patent UA-105760-C2 (UA)
Title: Bst2 antibody
IPC: C12P21/08
Filed: 2008-10-16
Abstract: BST2 antibodies are sorted by employing their ability of binding to splicing variants of a human BST2 antigen as a measure. As a result, a BST2 antibody capable of specifically recognizing BST2D (which is a substance reported to be expressed in a cancer cell at a high level) can be successfully obtained. The antibody can bind to a BST2D-expressing cell specifically. When the antibody is used for therapy, it becomes possible to inhibit the non-specific binding of the antibody to a tissue other than a target tissue (wherein the non-specific binding can cause the decrease in the concentration of the antibody in the blood). Also disclosed is a diagnostic agent comprising the antibody, which can specifically detect a BST2D-expressing tissue.
Patent UA-104849-C2 (UA)
Title: 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as inhibitors of janus kinases
IPC: C07D401/14
Filed: 2008-11-13
Abstract: The present invention provides substituted bicyclic heteroaryl compounds, 5 including, for example, 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.(I)
Patent UA-96552-C2 (UA)
Title: METHOD OF OBTAINING POWDERS ON BASE OF SUBSTITUTIONAL SOLID SOLUTIONS (Y1-XNdX)2O3 (X=0.005-0.1)
Inventor: PAZIURA YULIA IVANIVNA
IPC: C04B35/50
Filed: 2011-02-23
Abstract: The invention relates to nanotechnologies, namely to the methods of obtaining raw material for new close-packed consolidated functional nanomaterials. A method of obtaining powders on the base of substitutional solid solutions (YNd)O(x=0.005-0.l) includes preparation of initial solutions of nitrates of yttrium and neodymium, and also carbamide ((NH)CO), thus the concentrations in the working solution make Y(NO)– 0.0025-0.02 mole/l, Nd(NO)– 0.065-0.0013 mole/l, (NH)CO – 0.5-4.0 mole/l, slow precipitation of the precursor at their permanent mixing and heating for decomposition of carbamide, isolation of the precursor by filtration and multistage washing with distilled water and then by absolute ethanol (99.9 %) by means of centrifugation-dispersion, air drying of precursor at a temperature 25-, annealing the obtained powder of precursor on air under the temperature of 600- for 2-4 hours for crystallization of the product into phase ((YNd)O. The use of invention allows to obtain powders (YNd)Othat consist of spherical particles with diameter in the range of 60-200 nm and a high degree of their homogeneity.