Patent SG-11201808820Q-A (SG)
Title: Methods and kits for the diagnosis and risk stratification of patients with ischemia
Inventor: BADIMON MAESTRO LINA
IPC: G01N33/68
Filed: 2017-04-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 October 2017 (19.10.2017) WIPO I PCT (10) International Publication Number WO 2017/178521 Al 111111111111110111011111111111010111110111010111H11111010111111111110111111 (51) International Patent Classification: GO1N 33/68 (2006.01) (21) International Application Number: PCT/EP2017/058768 (22) International Filing Date: 12 April 2017 (12.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16382167.1 12 April 2016 (12.04.2016) EP (71) Applicants: INSTITUT CATALA DE CIENCIES CAR- DIOVASCULARS (ICCC) [ES/ES]; Hospital Santa Creu i Sant Pau, Pavello Antic Convent, Sant Antoni Maria Claret, 167, E-08025 Barcelona (ES). CONSEJO SU- PERIOR DE INVESTIGACIONES CIENTIFICAS; Serrano, 117, E-28006 Madrid, (ES). (72) Inventors: BADIMON MAESTRO, Lina; INSTITUT CATALA DE CIENCIES CARDIOVASCULARS (ICCC), Hospital Santa Creu i Sant Pau, Pavello Antic Convent Sant Antoni Maria Claret, 167, E-08025 Barcelona (ES). CUBEDO RAFOLS, Judit; INSTITUT CATALA DE CIENCIES CARDIOVASCULARS (ICCC), Hospital Santa Creu i Sant Pau, Pavello Antic Convent Sant Antoni Maria Claret, 167, E-08025 Barcelona (ES). PADRO CAPMANY, Teresa; INSTITUT CATALA DE CIEN- CIES CARDIOVASCULARS (ICCC), Hospital Santa Creu i Sant Pau, Pavello Antic Convent Sant Antoni Maria Claret, 167, E-08025 Barcelona (ES). (74) Agent: ALCONADA RODRIGUEZ„ Agustin; ABG PATENTES, S.L., Avda. de Burgos, 16D, Edificio EUR- OMOR, E-28036 Madrid (ES). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 1717 / 85 21 Al (54) Title: METHODS AND KITS FOR THE DIAGNOSIS AND RISK STRATIFICATION OF PATIENTS WITH ISCHEMIA (57) : The invention relates to methods for the diagnosis of ischemia or ischemic tissue damage, methods for predicting the progression of ischemia in a patient having suffered an ischemic event, for determining the prognosis of a patient having suffered an ischemic event and for determining the risk that a patient suffering from stable coronary disease suffers a recurrent ischemic event based on the detection of the levels of glycosylated Apo J. The invention relates as well to a method for the determination of glyc - osylated Apo J in a sample.