baber/WOPTO huggingface dataset:
Patent BR-112016019462-B8 (BR)
Title: Compostos heterocïclicos tricïclicos como inibidores de fosfoinosotida 3-cinase
Inventor: ALEXANDER RICHARD LIAM CECIL
IPC: A61K31/519
Filed: 2015-02-12
Abstract: COMPOSTOS HETEROCÍCLICOS TRICÍCLICOS COMO INIBIDORES DE FOSFOINOSOTIDA 3-CINASE.  A invenção refere-se a um composto de fórmula (I):  ou um sal farmaceuticamente aceitável do mesmo, em que: W é O, N-H, N- (C 1 -C 13 alquila) ou S; cada X é independentemente CH ou N; R1 é um heterocíclico saturado ou insaturado de 5 a 7 membros, opcionalmente substituído, contendo pelo menos 1 heteroátomo selecionado de N ou 0; R2 é LY; cada L é uma ligação direta, Cl-C10 alquileno, C2-C10 alquenileno ou C2-C10 alquinileno; Y é um heterocíclico não aromático de 5 a 12 membros, fundido, ligado em ponte ou espirocíclico, opcionalmente substituído, contendo até 4 heteroátomos selecionados de N ou O; e cada R3 é independentemente H, C1-C13 alquila, halogênio, fluoro-C1-C10 alquila, O-C1-C10 alquila, NH-C1-C10 alquila, S-C1-C10 alquila, O-fluoro-C1-C10 alquila, NH-acila, NH-C (O) -NH-C1-C10 alquila, C(O) -NH-C1-C10 alquila, arila ou heteroarila, em que os ditos compostos são de utilidade como inibidores da enzima fosfoinositida 3-cinase da classe IA, PI3K-p110(Delta) e, portanto, apresentam potencial utilidade na terapia do câncer e de doenças imunes e inflamatórias.
Patent BR-112017025564-B8 (BR)
Title: Anticorpos anti-ctla-4 e métodos de uso dos mesmos
Inventor: CORNELIA ANNE MUNDT
IPC: C07K16/28
Filed: 2016-05-27
Abstract: a presente descrição proporciona anticorpos que se ligam especificamente à ctla-4 humana e antagonizam a função de ctla-4. também são proporcionadas composições farmacêuticas compreendendo estes anticorpos, ácidos nucléicos que codificam estes anticorpos, vetores de expressão e células hospedeiras para produzir estes anticorpos, e métodos de tratamento de um indivíduo usando estes anticorpos.
Patent EP-1246529-B9 (EP)
Inventor: KEIFER DAVID
IPC: A01N43/90
Filed: 2001-01-05
Granted: 2005-06-08
Abstract: The present invention relates to protection of plants from unintended phytotoxic injury due to application of a herbicide to reduce competition for the plant of interest. A preferred herbicide used in the context of the present invention is clomazone. The unintended phytotoxic injury is avoided by application of a safening-effective amount of one or more of the compounds described by formula (I) wherein T and T<1 >are independently selected from the group of hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkenyl, and alkynyl; U is oxygen or sulfur, and; V, W, X, Y, and Z are independently selected from the group of hydrogen, halogen, alkyl, haloalkyl, and alkoxy. The present invention is preferably used for growing corn, wheat, and cotton in the presence of the otherwise phytoxic effects of clomazone, for example.
Patent EP-0636017-B9 (EP)
Inventor: WANEK MARY CHRIS
IPC: B32B7/02
Filed: 1993-12-15
Granted: 2001-03-21
Abstract: Disclosed is an absorbent structure comprising first and second surge management layers and an absorbent layer located between said first and second surge management layers. The first surge management layer comprises synthetic polymeric fibers and the second surge management layer comprises hydrophilic fibers. The density of the absorbent layer is greater than the density of the first and second surge management layers.
Patent AU-2006319001-B9 (AU)
Title: Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus
Inventor: TELLES JEAN-NOEL
IPC: C12Q1/70
Filed: 2006-11-23
Granted: 2013-05-02
Abstract: The invention concerns a double pair of oligonucleotides for amplifying two target sequences localized respectively in the H5 and N1 genes of the genome of the
Patent SE-218441-C1 (SE)
IPC: B01D63/08
Filed: 1965-07-21
Abstract: 1,080,070. Dialysis apparatus. GAMBRO A.B. June 24, 1966 [July 21, 1965], No. 28474/ 66. Heading B1X. A dialysis device, e.g. for purifying blood, consists of semipermeable diaphragms 10 and 11 arranged in flat parallel relationship or in spiral shape with spacer members 12 between every other pair of adjacent layers of diaphragm, the spacer members having elevations 4 and 15 which co-operate to bring the two layers of diaphragm between adjacent spacer members into mutual engagement at defined intervals and lesser elevations 18 and 19 maintaining the layers of diaphragm a definite distance apart at points between the points of mutual engagement. The elevations 18 and 19 have small end surfaces 20 and 21 compared with end surfaces 16 and 17 of elevations 14 and 15 such that while the space 23 containing blood has its volume appreciably reduced the area utilizable for diffusion is not greatly reduced. Purifying liquid, e.g. a salt solution, circulates in the spaces 22 between the elevations and the diaphragms with which the impurities diffusing through the diaphragms are removed. Inlet and outlet channels for the blood are provided at opposite sides of the device. Each channel is connected to a nozzle 6 (Fig. 1) at the exterior of the device and the channels have lens-shaped diversion member (26) (Fig. 4, not shown) provided between the spacing members and the diaphragms 10 and 11. These have narrow diversion tubes (27) through which blood passes to spaces 23. The salt solution is supplied and removed through nozzles 7 and 8 (Fig. 1). The elevations may be made so resilient that if the pressure in the salt solution decreases the entire device is compressed.
Patent DE-3225716-C1 (DE)
Title: Process for flue gas desulphurisation
Inventor: FISCHER HEINZ-JUERGEN ING
IPC: F23J15/08
Filed: 1982-07-09
Granted: 1983-06-01
Abstract: In the process, the clean gas stream is heated prior to entry into a heat exchanger by a fraction of clean gases, which are withdrawn after the heat exchanger and are mixed with the clean gases prior to the heat exchanger.
Patent DE-3436055-C1 (DE)
Title: Industrial furnace/dryer combination
IPC: F26B20/00
Filed: 1984-10-02
Granted: 1986-02-27
Abstract: The invention relates to an industrial furnace (10) in combination with a dryer (30), the dryer (30) being arranged directly next to or above the furnace (10) and dryer (30) and furnace (10) being connected by devices (22a, b, c, d, 23, 24a, b, c, 26) for conducting waste gas from the furnace (10) to the dryer (30). <IMAGE>
Patent DE-3437923-C1 (DE)
Title: Voltage-controlled oscillator
Inventor: KOGA TAKASHI
IPC: H03K3/282
Filed: 1984-10-17
Granted: 1986-07-17
Abstract: A resistor (R) is connected together with a charging capacitor (C) in series between the emitter of transistors (Q6, Q7) in order to form an emitter-coupled astable multivibrator which is used as a voltage-controlled oscillator. The resistance (Ra) of the resistor (R) is given by  Ra =  tau d1 +  tau d2 DIVIDED 2Ca Ca being the capacitance of the capacitor (C) and ( tau d1 +  tau d2) being a delay time during an oscillation period which is defined by the circuit elements. <IMAGE>
Patent DE-3439921-C1 (DE)
Title: Element for anchoring wall parts in the undercut longitudinal groove, having an opening slot, of a receiving part
Inventor: RUECK HANS-PETER
IPC: E04H15/64
Filed: 1984-11-02
Granted: 1986-01-30
Abstract: The subject of the invention is an element for anchoring wall parts, which can be fitted together by means of said element and consist of deformable sheet-like material or solid material, in the undercut longitudinal groove, having an opening slot, of a receiving part, into which groove the element can be introduced. It is the object of the invention to provide an element of this type which permits reliable anchoring of the respective wall part in the groove of the receiving part in a simple and time-saving manner which does not involve a great deal of effort. This object is achieved according to the invention in that the thickness of the element is dimensioned to be smaller than the width of the opening slot (9) of the longitudinal groove (10), such that the element can be inserted through the opening slot into the interior of the longitudinal groove, and that, after it has been pushed into the longitudinal groove, the change in the volume and contours of the element is such that it reliably prevents the element from being pulled out of the longitudinal groove transversely to the longitudinal extent thereof (Figure 1). <IMAGE>
Patent DE-3518901-C1 (DE)
Title: Movable bobbin magazine for textile machines
Inventor: STEPPUHN BRUNO MASCH-ING
IPC: B65H49/38
Filed: 1985-05-25
Granted: 1987-01-02
Abstract: In order to bring bobbins up to a textile machine for further processing so that they take up only a small amount of space and are in a position favourable for handling, a movable bobbin magazine for textile machines, which has a travelling trolley movable along a rail in the manner of a trolley conveyor and carrying a plurality of bobbin receptacles, is characterised in that the bobbin receptacles are attached to a horizontally collapsible scissor-type grid having horizontally directed axes of articulation.
Patent DE-3635141-C1 (DE)
Inventor: MECKE NORBERT DR
IPC: B41M5/26
Filed: 1986-10-15
Granted: 1988-03-03
Abstract: 1. A thermal carbon ribbon containing a resin-bonded fusible ink on a substrate, characterised in that, during the thermal printing process, fusible solid polymer globules (4) are distributed in the ink (3) in a continuous solid phase (5) which contains a second polymer for melting during the thermal printing process, a wax and/or a wax-like substance.
Patent DE-3707599-C1 (DE)
Title: Shaft sealing ring with a lubricant chamber
Inventor: HESSE EDWIN DIPL-ING
IPC: F16J15/3252
Filed: 1987-03-10
Granted: 1988-06-01
Abstract: In the sealing off of media of low lubricity, the life of shaft sealing rings is severely limited. The new shaft sealing ring provides a seal with an increased life. The shaft sealing ring is provided with a lubricant chamber (6, 6') which functions as a forced lubrication means. The shaft sealing ring is suitable, for example, for sealing off shafts in washing machines. <IMAGE>
Patent DE-3818018-C1 (DE)
Title: Head restraint for motor-vehicle seats
IPC: B60N2/48
Filed: 1988-05-27
Granted: 1989-08-31
Abstract: A head restraint for motor vehicles has a padded support which can be encased in foam in the mould. This padded support is provided with at least one supporting rod which serves to hold the padded support on a seat back and is connected to the padded support by means of an adjusting device. The adjusting device is received together with the upper supporting-rod region in an adjustment cavity in the padded support, which cavity permits the padded support to be changed in position relative to the supporting rod and forms an outwardly open access opening through which the supporting rod passes. The adjustment cavity is filled by a hollow body which has an elastically flexible wall, in the compressed condition can be introduced through the access opening and can be positioned against the inner wall of the adjustment cavity. With its opening region situated within the access opening in the padded support, the hollow body forms sealing surfaces which seal the adjusting device and the interior of the hollow body from the outside in a liquid-tight manner.