Patent SG-11201808495S-A (SG)
Title: Methods for predicting the usefulness of proteins or protein fragments for immunotherapy
Inventor: VORMEHR MATHIAS
IPC: G01N33/53
Filed: 2017-05-10
Abstract: cf) a) 60 a) co 5 40 a) 2 N °- 20- 0 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 November 2017 (16.11.2017) WIPO I PCT omit VIII Hot 0 ommolum 010110111110 oimIE (10) International Publication Number WO 2017/194610 Al (51) International Patent Classification: G01N 33/50 (2006.01) GO1N 33/53 (2006.01) GO1N 33/68 (2006.01) (21) International Application Number: PCT/EP2017/061196 (22) International Filing Date: 10 May 2017 (10.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2016/060897 13 May 2016 (13.05.2016) EP (71) Applicants: BIONTECH RNA PHARMACEUTICALS GMBH [DE/DE]; An der Goldgrube 12, 55131 Mainz (DE). TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GEMEIN- NUTZIGE GMBH [DE/DE]; FreiligrathstraBe 12, 55131 Mainz (DE). (72) Inventors: VORMEHR, Mathias; Alexander-Diehl- StraBe 10, 55130 Mainz (DE). SAHIN, Ugur; Philipp-von- Zabern-Platz 1, 55116 Mainz (DE). SCHRORS, Barbara; Untere Zahlbacher StraBe 54a, 55131 Mainz (DE). LOW- ER, Martin; Franziska-Kessel-StraBe 61, 55131 Mainz (DE). BOEGEL, Sebastian; BergstraBe 13, 67823 Ober- moschel (DE). (74) Agent: SCHNAPPAUF, Georg; ZSP Patentanwalte PartG mbB, Hansastrasse 32, 80686 Mfinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (54) Title: METHODS FOR PREDICTING THE USEFULNESS OF PROTEINS OR PROTEIN FRAGMENTS FOR IM- MUNOTHERAPY Fig. 1 Location cf . <?\" ,qc :•\"$‘ <r>c \(3 ( <5 1- c . Q .\ c 6 'r- c) .e 6 9 ‘ ..V.) 0 9 CV .° 6° MI Published epitopes (n=129) Proteome (n=500) (57) : The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for im- munotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypep- tides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines. [Continued on next page] WO 2017/194610 Al MIDEDIMOMOIDEIROIDEMOMOIROMEMOMMOVOIMIE PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))