Patent SG-11201908599U-A (SG)
Title: Microrna 19a/19b for use in treating a pathological condition associated with bone loss or reduced muscle function
Inventor: HESSE ERIC
IPC: A61K38/29
Filed: 2018-04-06
Abstract: PCTEP/058828 06 April 2018 (06.04.2018) English English (51) International Patent Classification: A61K 31/711 (2006.01) A61P 19/08 (2006.01) A61K 45/06 (2006.01) A61P 19/10 (2006.01) A61K 38/29 (2006.01) (21) International Application Number: (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: (26) Publication Language: (30) Priority Data: LU100182 06 April 2017 (06.04.2017) LU (71) Applicant: UNIVERSITATSKLINIKUM HAM- BURG-EPPENDORF [DE/DE]; Martinistr. 52, 20246 Hamburg (DE). (72) Inventors: HESSE, Eric; Methfesselstr. 76, 20257 Ham- burg (DE). TAIPALEENMAKI, Hanna; Methfesselstr. 76, 20257 Hamburg (DE). SAITO, Hiroaki; Siemersplatz 4, 22529 Hamburg (DE). (74) Agent: UEXKULL & STOLBERG PART- NERSCHAFT VON PATENT- UND RECHTSAN- WALTEN MBB; Beselerstr. 4, 22607 Hamburg (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, O N 00 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT onion °nolo HE limmoilowo oimIE (10) International Publication Number WO 2018/185270 Al (54) Title: MICRORNA 19A/19B FOR USE IN TREATING A PATHOLOGICAL CONDITION ASSOCIATED WITH BONE LOSS OR REDUCED MUSCLE FUNCTION (57) : The invention relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with bone loss, in particular osteoporosis and osteogenesis imperfect (01). The inhibitors are also useful for inducing an anabolic effect in bone, either alone or when administered in combination with parathyroid hormone or a recombinant fragment thereof. The invention further relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with reduced muscle function, in particular muscle degeneration and muscle atrophy. The inhibitors are also useful for stabilizing and/or strengthening muscle function. In addition, inhibitors of microRNAs 19a and 19b can be used for treating or preventing cancer-related bone destruction or bone metastasis.