Patent SG-11201810318R-A (SG)
Title: Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses
Inventor: PAUS RALF
IPC: A61K8/34
Filed: 2017-05-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER (19) World Intellectual Property 11111111111111111111101011111111111 Organization International Bureau (43) International Publication Date .....0\"\"\" 23 November 2017 (23.11.2017) WIPO I PCT THE PATENT COOPERATION TREATY (PCT) 011101111111111111111110111110111111111110111111 (10) International Publication Number WO 2017/198818 Al (51) (21) (22) (25) (26) (30) (71) (72) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 8/34 (2006.01) A61Q 7/00 (2006.01) kind of national protection available): AE, AG, AL, AM, International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/EP2017/062110 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, International Filing Date: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 19 May 2017 (19.05.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 102016000051626 19 May 2016 (19.05.2016) IT (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, Applicant: GIULIANI S.P.A. [IT/IT]; Via Palagi 2, 20129 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Milano (IT). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventors: PAUS, Ralf; Hummelsbuetteler Kirchen- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, weg 82, 22339 HAMBURG (DE). CHERET, Jeremy; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Riischhausweg 17, 48149 Muenster (DE). HATT, Hanns; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, StolzestraBe 39, 44789 BOCHUM (DE). BARONI, Sergio; TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Via Piazzolo 3, 24030 VILLA D'ADDA (IT). KM, ML, MR, NE, SN, TD, TG). Agent: APPOLONI, Romano et al.; NOTARBARTOLO Declarations under Rule 4.17: & GERVASI S.P.A., Corso di Porta Vittoria 9, 20122 Mi- _ of inventorship (Rule 4.17(iv)) lano (IT). (74) _ = = (54) Title: COMPOUNDS FOR PROMOTING HAIR GROWTH AND COMPOSITIONS FOR SUCH USES AND/OR INHIBITING OR DELAYING HAIR LOSS IN HU- (57) : The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and form together a dou- R2 ble bond, or R1 and form together a cyclopropyl group; R2 R3, R4 are the same or different and independently chosen from hydro- gen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7 = methyl, or ethyl; R8 = hy- drogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharma- ceutical compositions suitable for such use. - MANS, — _ 20 17 / 1988 18 Al 1 11 111 1111111111 111111 11111 1 111111111 11 11 1 11 111 11111 I -dam Fig. 1 C [Continued on next page] WO 2017/198818 Al MIDEDIMOMMIDIRMEMOMOMEIMMEEIMOVOIS Published: — with international search report (Art. 21(3))