baber/WOPTO huggingface dataset:
Patent AU-2020363561-A1 (AU)
Title: The preparation method thereof and application thereof of different configurations of glp-1 analogue dimers with modification in treatment of type ii diabetes
Inventor: TANG SONGSHAN
IPC: C07K19/00
Filed: 2020-11-09
Abstract: Provided in the present invention is a use of novel GLP-1 fatty acid-modified or non-modified dimers of different configurations for a pancreas protecting or glucose reducing effect in treating type 2 diabetes. The dimers of the present invention are formed from a disulfide bond formed by means of cysteine oxidation in two same cysteine-containing GLP-1 monomers. An H-type GLP-1 homodimer of the present invention (having a disulfide bond formed inside the peptide chain), without reducing activity, markedly increases the glucose reduction duration of the GLP-1 dimer. The duration of activity of the provided GLP-1 analog dimer in vivo reaches 19 days, a marked extension relative to the in vivo activity of 3 days of positive control drug Liraglutide, or currently reported long-acting GLP-1 analogues, greatly advancing the technical progress of long-acting GLP-1 drugs and facilitating the clinical application and popularization thereof. Meanwhile, a U-type homodimer (having a disulfide bond formed at the C-terminus of the peptide chain) has no impact on blood glucose, but can clearly protect pancreas exocrine cells such as in acini and ducts.
Patent AU-2020367388-A1 (AU)
Title: Examination apparatus for medical examination of an animal
Inventor: ANLIKER URS
IPC: A01K29/00
Filed: 2020-10-15
Abstract: The present invention relates to an examination apparatus for medical examination, in particular determination of a blood pressure, of an animal, in particular an animal having a paw, particularly preferably an animal from the subfamily of the Felinae. The examination apparatus has a sensor device for the optical examination of an arterial blood flow of the animal, in particular for performing a photoplethysmography. For this purpose, the sensor device has at least one emitter for the emission of elec- tromagnetic radiation and at least one detector for the detection of the radiation emit- ted by the emitter. The sensor device preferably has several emitters and several detectors, wherein the emitters and detectors are arranged in a periodic structure. Alternatively or additionally, the sensor device has a limiting device which defines a border of a detection region of the sensor device so that a distance of the border from the sensor device is more than 0.5 mm and/or less than 5 mm.
Patent AU-2020391126-A1 (AU)
Title: Digital imaging system and method
Inventor: HUNT BARRY F
IPC: G02B7/36
Filed: 2020-11-23
Abstract: A system and method for acquiring images of objects distributed within a specimen affixed to a surface of a slide, the specimen having an uneven height relative to the slide surface using a camera having an objective lens with an optical axis that forms a non-orthogonal angle with the surface of the slide, the method including acquiring a first plurality of images of a first linear portion of the specimen; evaluating a focus of objects within the linear portion of the specimen captured in the first plurality of images; and acquiring a second plurality of images of the first linear portion or of a second linear portion of the specimen different from the first, wherein a height of the objective lens relative to the slide surface is varied during acquisition of the second plurality of images based on the evaluated focus of the objects captured in the first plurality of images.
Patent AU-2020397953-A1 (AU)
Title: Placenta-derived allogeneic CAR-T cells and uses thereof
Inventor: KARASIEWICZ-MENDEZ KATHY
IPC: C07K14/725
Filed: 2020-12-04
Abstract: The present invention discloses populations of T cells expressing a chimeric antigen receptor (CAR), wherein said T cells are placental T cells derived from cord blood, placental perfusate, or a mixture thereof. Such populations of cells are shown to be improved in a number of aspects over alternative populations of cells such as those derived from peripheral blood mononuclear cell T cells. It also discloses methods of treating cancer, such as a hematologic cancer, e.g., a B cell cancer, or a symptom thereof in a patient in need thereof. These methods omprise administering to the patient an amount of the population of T cells of any one of the invention effective to alleviate the cancer or symptom thereof in the patient.
Patent AU-2020407100-A1 (AU)
Title: Low nucleation temperature polythioether prepolymers and uses thereof
Inventor: RAO CHANDRA B
IPC: C08K5/49
Filed: 2020-12-17
Abstract: Polythioether prepolymers that have a low nucleation temperature are disclosed. The polythioether prepolymers are stable at low temperature storage conditions for an extended period of time. Compositions prepared using the low nucleation temperature polythioether prepolymers are useful as sealants.
Patent AU-2020409539-A1 (AU)
Title: Mine vehicle safety control
Inventor: MÄKELÄ HANNU
IPC: E21C41/16
Filed: 2020-12-15
Abstract: According to an example aspect of the present invention, there is provided a method, comprising: (310) receiving a tunnel model of an underground tunnel system of a worksite, (320) receiving a route point entry indicative of a route point position for a mine vehicle in the tunnel system, (330) defining, for controlling obstacle detection for the mine vehicle, at least one lateral safety margin parameter on the basis of vehicle dimension data and processing the tunnel model in respect to the route point position, and (340) associating the at least one lateral safety margin parameter with the route point position.
Patent WO-2021237272-A1 (WO)
Title: Systems catching residual energy from an electric coil
Inventor: LAN GORDON
IPC: H02J7/00
Filed: 2021-05-04
Abstract: Energy saving and sustainability have become hot topics nowadays. Electric transportation applications, such as electric vehicles, always pursue higher energy efficiency other than applications with secured power sources. Therefore, lots of research and development work have been carried out to pursue the energy efficiency, such as redesign the motor itself and/or, use electronic techniques. This invention deploys electronic techniques to pursue higher efficiency. To prove the idea and solutions, 2 prototypes using 2-phase and 3-phase PMBLDC motors have been built for the purpose. They disclose the methods to catch the residual energy from an armature and send it back to the rechargeable power sources without affecting the motor's running driven by switching manner. The implementation is simple and cheap. By recycling the residual energy, it extends the run time of battery systems, achieving higher energy efficiency. The benefit is huge, but not limited to, in economical and environmental fields.
Patent AU-2021203972-A1 (AU)
Title: A solvent-free melt polycondensation process of making furan-based polyamides
Inventor: PERCEC SIMONA
IPC: C08G69/28
Filed: 2021-06-15
Abstract: Disclosed herein are processes of making furan-based polyamides using 
solvent-free melt condensation of a diamine and an ester derivative of 2,5
furandicarboxylic acid with a C2 to C12 aliphatic diol or a polyol. The processes 
5 comprise a) forming a reaction mixture by mixing one or more diamines, a diester 
comprising an ester derivative of 2,5-furandicarboxylic acid with a C2 to C12 
aliphatic diol or a polyol, and a catalyst, such that the diamine is present in an 
excess amount of at least 1 mol% with respect to the diester amount; and b) melt 
polycondensing the reaction mixture in the absence of a solvent at a temperature 
10 in the range of 60 °C to a maximum temperature of 250 °C under an inert 
atmosphere, while removing alkyl alcohol to form a furan-based polyamide, 
wherein the one or more diamines comprises an aliphatic diamine, an aromatic 
diamine, or an alkylaromatic diamine.
Patent AU-2021209153-A1 (AU)
Title: Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels
Inventor: SEEHRA JASBIR
IPC: A61K38/00
Filed: 2021-07-26
Abstract: In certain aspects, the present invention provides compositions and methods for 
increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and 
primates, and particularly in humans.  
5
Patent AU-2021212100-A1 (AU)
Title: Method and system for enhanced validation of cryptograms in cloud-based systems
Inventor: COLLINGE MEHDI
IPC: G06Q20/38
Filed: 2021-08-06
Abstract: OF THE DISCLOSURE 
A method for enhanced validation of cryptograms for varying account 
number lengths includes: storing one or more primary account numbers and a 
5 plurality of formatting templates, each template being associated with an account 
number length; receiving a selection indicating a specific primary account number; 
identifying a specific formatting template where the associated account number length 
corresponds to a length of the specific primary account number; receiving an 
unpredictable number from a point of sale device; generating a cryptogram based on 
10 at least the unpredictable number and one or more algorithms; generating a data 
string, wherein the data string includes at least the generated cryptogram, the specific 
primary account number, and the unpredictable number, and wherein the data string is 
formatted based on the identified specific formatting template; and electronically 
transmitting the generated data string to the point of sale device.
Patent AU-2021220870-A1 (AU)
Title: Methods of treating age-related and inflammatory diseases
Inventor: WONG HING C
IPC: C12N5/0783
Filed: 2021-02-11
Abstract: Provided herein are methods of treating an aging-related disease or inflammatory disease in a subject that include (i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or monoclonal antibody; and (ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or AGE inhibitor.
Patent AU-2021228781-A1 (AU)
Title: Contactless inspection of reproductive cellular structures using optical measurement of biomechanical properties
Inventor: YOO JANG LAWRENCE
IPC: G01N21/47
Filed: 2021-03-01
Abstract: A method of measuring at least one biomechanical property of a reproductive cellular structure is provided. The method includes illuminating the reproductive cellular structure with radiation; detecting at least a portion of radiation scattered from the illuminated reproductive cellular structure; analyzing a frequency spectrum of the detected scattered radiation to identify at least one Brillouin frequency shift in the frequency spectrum; and determining the at least one biomechanical property based on the Brillouin frequency shift. The method further includes determining a viability index of the reproductive cellular structure based on the at least one biomechanical property.
Patent AU-2021230410-A1 (AU)
Title: "intraoperative localisation systems and methods"
Inventor: MILES BRAD
IPC: G16H30/40
Filed: 2021-02-26
Abstract: This disclosure relates to an intraoperative localisation system for total joint replacement of a joint of a patient by a surgeon, the joint being associated with a bone. The localisation system comprises: an X-ray imaging device to create a digital X-ray image of the joint and a localisation object during a total joint replacement surgery; a computer system configured to: store a surgical plan comprising a digital three-dimensional model; receive the digital X-ray image of the joint and the localisation object during the total joint replacement surgery; determine a pose of the localisation object relative to the bone or the joint, based on the digital X-ray image; assess the pose of the localisation object against the surgical plan; and provide an indication of a clinical consequence of the pose in relation to the surgical plan to the surgeon.
Patent AU-2021251111-A1 (AU)
Title: Locking mechanisms for endoscopic devices
Inventor: WILDER EVAN
IPC: A61B1/00
Filed: 2021-04-06
Abstract: A medical device may comprise a sheath configured to be inserted into a body lumen of a patient. A distal end of the sheath may include an elevator for changing an orientation of a medical device. A handle may include an actuator. The actuator may be operably connected to the elevator. Activation of the actuator may cause movement of the elevator. An engaging portion may, in at least one configuration of the handle, protrude from a surface of a handle body toward the actuator. A force exerted by the user on at least one of the actuator or the engaging portion may cause the handle to transition between (a) a first configuration in which the engaging portion interacts with the actuator to inhibit movement of the actuator relative to the engaging portion and (b) a second configuration in which the actuator is movable relative to the engaging portion.
Patent AU-2021252550-A1 (AU)
Title: Multi-drug formulations for subcutaneous biodegradable reservoir device
Inventor: JOHNSON LEAH MARIE
IPC: A61K31/7076
Filed: 2021-04-07
Abstract: A reservoir device comprising an active agent formulation contained within a reservoir is described. The active agent formulation comprises more than one active agent. The reservoir is defined by a biodegradable, permeable polymer membrane. The membrane allows for diffusion of the more than one active agent of the formulation there through when positioned subcutaneously in a body of a subject.
Patent AU-2021258516-A1 (AU)
Title: Treatment of diseases with CLEVER-1 inhibition in combination with an interleukin inhibitor
Inventor: JALKANEN JUHO
IPC: C07K16/24
Filed: 2021-04-19
Abstract: Use of an agent capable of inhibiting CLEVER-1 expression or binding to CLEVER-1 in combination with an inhibitor of interleukin and/or the respective receptor, and optionally further with an agent capable of binding to interferon-alpha/beta receptor (IFNAR) in a treatment of diseases.
Patent AU-2021263857-A1 (AU)
Title: Security control module and system
Inventor: STUDERUS PAUL
IPC: G07C9/28
Filed: 2021-04-22
Abstract: A security control module (10) for controlling access through a passageway (4) of a secure control area (A), comprising an ultra-wideband transceiver (12) configured to establish an ultra-wideband transmission with a mobile device (100) and a processing unit (14) configured to determine a first distance (D1) between the security control module (10) and the mobile device (100) by processing signal properties of the ultra-wideband transmission. The security control module (10) is configured to receive a second distance (D2) from a further security control module (10', 20) arranged at a spacing distance (D) apart, the second distance (D2) being indicative of a distance between the further security control module (10', 20) and the mobile device (100). The processing unit (14) is configured to determine the relative position of the mobile device (100) with respect to the security control module (10) based on the first and second distance (D1, D2).
Patent AU-2021271808-A1 (AU)
Title: Administration of SUMO-activating enzyme inhibitor and anti-CD38 antibodies
Inventor: HUSZAR DENNIS
IPC: A61K31/506
Filed: 2021-05-14
Abstract: The present disclosure provides methods, pharmaceutical compositions, and kits for treating cancer or autoimmune disease in patients in need thereof. The methods comprise administering to a patient in need a small ubiquitin-like modifier (SUMO) activating enzyme (SAE) inhibitor, such as [(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1- yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxy-cyclopentyl]methyl sulfamate (Compound I-263a) or a pharmaceutically acceptable salt, in combination with one or more anti-CD38 antibodies. Also provided are medicaments for use in treating cancer or autoimmune disease.
Patent AU-2021312871-A1 (AU)
Title: Chimeric antigen receptors with enhanced signaling and activities and uses thereof
Inventor: BETHUNE MICHAEL THOMAS
IPC: C07K19/00
Filed: 2021-07-21
Abstract: Provided herein are recombinant antigen receptors, for example chimeric antigen receptors (CARs), that comprise modified cytoplasmic domains that provide improved signalling and thereby provide improved performance and safety. Also provided are polynucleotides encoding the recombinant antigen receptors, vectors comprising the polynucleotides, and engineered immune cells comprising the vectors and/or polynucleotides. The invention further provides methods for engineering immune cells to express the recombinant antigen receptors. Improved recombinant antigen receptor signalling is also provided by co-expressing a first recombinant antigen receptor and a second recombinant antigen receptor or co-expressing a recombinant antigen receptor and a protein involved in transducing the signal from the activated recombinant antigen receptor. Also provided are methods of treating a variety of conditions, including, but not limited to, blood cancers and cancers characterized by solid tumors, by administering the engineered cells to patients suffering from such a condition.
Patent AU-2021335102-A1 (AU)
Title: Active electrode material
Inventor: GROOMBRIDGE ALEXANDER
IPC: H01M4/131
Filed: 2021-08-27
Abstract: The invention relates to active electrode materials and to methods for the manufacture of active electrode materials. Such materials are of interest as active electrode materials in lithium-ion or sodium-ion batteries. The invention provides an active electrode material expressed by the general formula M1
Patent AU-2021373358-A1 (AU)
Title: Immunogenic compositions for use in pneumococcal vaccines
Inventor: ANDERSON ANNALIESA SYBIL
IPC: A61K39/09
Filed: 2021-11-01
Abstract: An object of the present invention is to provide immunogenic compositions for protection against
Patent AU-2021392820-A1 (AU)
Title: Field telemetry system for an environmental control system
Inventor: KNOWLES GREGORY
IPC: H04Q9/02
Filed: 2021-12-03
Abstract: A field telemetry system for an environmental control system of a vehicle comprising sensors for monitoring an element or characteristic of the environmental control system. A processing unit is in data and control communication with each of the sensors. Data received from the sensors is received by the processing unit and stored in temporary memory for further processing. Depending on the data received, the further processing may involve the immediate packaging of the data to create packaged telemetry data. A wireless communications system, in data communication with the processing unit, communicates the packaged telemetry data to a location external to the vehicle..
Patent AU-2021397239-A1 (AU)
Title: Directional device for epidural needle
Inventor: PYLES STEPHEN T
IPC: A61B17/34
Filed: 2021-12-07
Abstract: A device is described for marking a path on a skin surface for inserting an epidural needle into an epidural space. The device includes a first arm having one or more holes spaced apart along the length of the first arm. A pin is attached at the proximal end of the first arm. A second arm has a proximal end attached to the pin allowing the first and second arms to rotate about the pin to adjust an angle separating the first and second arms. The second arm has one or more holes spaced apart along the length of the second arm. The holes on the first and second arms provide locations for marking the path on the skin surface to insert the epidural needle.
Patent AU-2021427644-A1 (AU)
Title: Footwear with active temperature and humidity control
Inventor: SPINA DANIELE
IPC: A43B7/00
Filed: 2021-09-14
Abstract: Footwear (1) comprising a housing seat (2) for a foot (3) and further comprising a system (20) for actively controlling the temperature and humidity inside the housing seat (2), wherein said active control system (20) comprises: an electronic control unit (21); a temperature sensor (22) and a humidity sensor (23) operatively connected to the electronic control unit (21) for supplying the electronic control unit (21) with a first electrical signal bearing information correlated to the temperature inside the housing seat (2) and a second electrical signal bearing information correlated to the humidity inside the housing seat (2), respectively; at least one temperature control element (32) operatively connected to the electronic control unit (21) and which is controllable for varying the temperature inside the housing seat (2); characterized in that said active control system (20) further comprises at least one humidity control element (33) operatively connected to the electronic control unit (21) and which is controllable for varying the humidity inside the housing seat (2), wherein said at least one humidity control element (33) is adapted and configured to vary the humidity by means of electrolysis.
Patent AU-2021446660-A1 (AU)
Title: Information processing program, information processing method, and information processing apparatus
Inventor: KATAOKA MASAHIRO
IPC: G16B30/10
Filed: 2021-05-18
Abstract: The information processing device calculates a second index that indicates the positions of a single amino acid on a codon file on the basis of a first index that indicates the positions of a plurality of codons indicating the single amino acid and having different nucleotide sequences from each other on the codon file. The information processing device identifies each of the positions of an amino acid sequence appearing repeatedly on the codon file on the basis of the second index. The information processing device identifies codon sequences corresponding to the positions of the amino acid sequence appearing repeatedly on the codon file as codon sequences having homology with each other.
Patent AU-2022200384-A1 (AU)
Title: Toilet pan body and its method of manufacturing
Inventor: MOORE GARRY
IPC: A47K13/24
Filed: 2022-01-20
Abstract: A ceramic toilet pan (12) has a raised rear portion (18) to which a hinge tube (28) may be 
accurately located and fixed in position for example by adhesive using a jig (22) despite 
variations in pan body size due to ceramic firing, a water pump (82) and air pump (102) being 
provided for flushing the toilet pan (10) when a seat (58) and lid (56) are in a closed position, 
the seat and lid being rotationally mounted to the pan (12) by a horizontal hinge pin (180) 
located in the hinge tube (28), a latch member (194) being provided for latching the lid (56) and 
seat (58) closed, a cistern having an overflow weir (320).  
Fig. 2
2/43 
144 
142 146 
140 
124 _ _ _ _ 118 
-122 
| 120 
102--- i 136 
Air 1,42' 148 138 
pump 44132 131 
82 Water 112 
pump 
114 
104~ 87'4 
86 
-130_ 
- -88 
128'-9 
94 
921 
L50 
100 98 
FIG. 2
Patent AU-2022201196-A1 (AU)
Title: Pharmaceutical composition comprising acetaminophen and ibuprofen
Inventor: CALLAHAN MATT
IPC: A61P29/00
Filed: 2022-02-22
Abstract: It is known to take acetaminophen in combination with ibuprofen. It can be a problem, or at least a 
disadvantage, if these substances do not act fast enough in the body. It is an object of the invention to 
go at least some way towards addressing this. According to the invention there is a solid oral dosage 
5 form containing 325 mg (± 5%) of acetaminophen and 97.5 mg (± 5%) of ibuprofen or 500 mg (± 5%) of 
acetaminophen and 150 mg (± 5%) of ibuprofen, wherein the ibuprofen has a [D50] between 1 and 9 
pm.  
0