Patent SG-11201809695T-A (SG)
Title: Modulators of the integrated stress pathway
Inventor: SIDRAUSKI CARMELA
IPC: C07D471/04
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111 0 1101010 11111 010 11111 0 11 01111111 0011111100111111110 1111 0111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/193034 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: C07D 213/73 (2006.01) C07D 261/08 (2006.01) C07D 317/64 (2006.01) C07D 261/20 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. SC, TR, C07D 231/56 (2006.01) C07C 235/00 (2006.01) C07D 401/04 (2006.01) C07D 271/113 (2006.01) (84) Designated States (unless otherwise indicated, for every CO7D 237/14 (2006.01) CO7D 213/30 (2006.01) CO7D 237/16 (2006.01) CO7D 213/64 (2006.01) CO7D 405/08 (2006.01) CO7D 213/66 (2006.01) CO7D 241/18 (2006.01) A61K 31/44 (2006.01) CO7D 471/04 (2006.01) A61P 35/00 (2006.01) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TZ, TJ, LV, (21) International Application Number: PCT/US2017/031360 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, KM, ML, MR, NE, SN, TD, TG). GW, (22) International Filing Date: 05 May 2017 (05.05.2017) Published: — with international search report (Art. 21(3)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: _ 62/332,278 05 May 2016 (05.05.2016) US (71) Applicants: CALICO LIFE SCIENCES [US/US]; 1170 = Veterans Blvd, South San Francisco, CA 94080 (US). AB- — BVIE, INC. [US/US]; 1 North Waukegan Road, North = Chicago, IL 60064 (US). Inventors: SIDRAUSKI, Carmelo; 20434 Walnut Ave, Saratoga, CA 95070 (US). PLIUSHCHEV, Marina; 1834 — (72) Ridge Avenue, Unit 108, Evanston, IL 60201 (US). FROST, Jennifer, M.; 635 Yorktown Lane, Gurnee, IL 60031 (US). BLACK, Lawrence, A.; 993 Green Meadow = = Avenue, Vernon Hills, IL 60061 (US). XU, Xiangdong; — _ 993 Green Meadow Avenue, Vernon Hills, IL 60061 (US). = SWEIS, Ramzi, Farath; 1012 Plaister Avenue, Lake Bluff, IL 60044 (US). SHI, Lei; 1908 Trevino Terrace, Vernon = Hills, IL 60061 (US). ZHANG, Qinwei, I.; 1820 S Falcon = Drive, Libertyville, IL 60048 (US). TONG, Yunsong; 1408 Braxton Road, Libertyville, IL 60048 (US). HUTCHINS, Charles, W.; 31005 Prairie Ridge Road, Green Oaks, IL = = 60048 (US). CHUNG, Seungwon; 1512 Virginia Avenue, = Libertyville, IL 60048 (US). DART, Michael, J.; 844 Yale = — Lane, Highland Park, IL 60035 (US). = — (74) Agent: LARKIN, Angelyn et al.; Goodwin Procter LLP, = 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, — 1-1 71' 0 en HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, M KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 0\ MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 1-1 IN 1-1 (54) 0 Title: MODULATORS OF THE INTEGRATED STRESS PATHWAY N (57) : Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) 0 and for treating related diseases; disorders and conditions.