Patent SG-11201903644V-A (SG)
Title: Provision of a therapeutically active cell product
Inventor: ORLOWSKI WOJCIECH
IPC: A61K35/28
Filed: 2017-08-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 11111111110111110100111111001111111111111111H011111011110111111 Organization International Bureau (10) International Publication Number 0 (43) International Publication Date .....0\"\" WO 2018/039810 Al 08 March 2018 (08.03.2018) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: E. BLUM & CO. AG; Vorderberg 11, 8044 Ziirich C12N 5/0775 (2010.01) A61K 35/28 (2015.01) (CH). C12N 5/077 (2010.01) (81) Designated States (unless otherwise indicated, for every International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/CH2017/000080 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 29 August 2017 (29.08.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, Publication Language: English MG, MK, MN, WV, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 1109/16 29 August 2016 (29.08.2016) CH TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Applicant: PDI PHARM DEVELOPMENT INTER- (84) Designated States (unless otherwise indicated, for every NATIONAL AG [CH/CH]; Bahnhofstrasse 4, 6052 Her- kind of regional protection available): ARIPO (BW, GH, giswil (CH). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventor: ORLOWSKI, Wojciech; u. Boleslawa Szczo- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, drego 20/7, 92 414 Lodz (PL). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, • - 4 - ' . Fp ' : . . . 7.. j ,_ , . 5 , s t, ,... . , C , ,- t 0 0 ;,.. 1— , ^ n S a , z r , . . , P 0 FL , , c ' cp_ c , r a e r , c- , o .. c i '' E ' - c s E 1 1: ' - t .1 1-- 1 .t . z i - . c. 0 .t 7 0 co 0- , c 7, • •• ia - 0 CD ,__ , , › . Clin ica l score = C q - ' g ' , ,- E7 , 0 E S- 1F -D ' c t, . t. , t, .. : ,- © in , - - L .. . U4 [ 4 VI t O 4 In A. (. 11 Ul . . 4 , 5 .t , ` M • P' ' I * (54) © particular OF A THERAPEUTICALLY ACTIVE CELL PRODUCT provided. The prog- use, in . : t . . 1 3 5 7 9 1113151719212325272931333537394143454749515355575961636567697173757779818385878991 Clinical observation [days] —1k— IIA active cell product and an ex vivo method for preparing it from a tissue donation are vitro immuno- depletion of hematopoietic stem cells and cells of hematopoietic lineage. The therapeutically by the method comprises a portion of non-hematopoietic stem cells and/or pluripotent stem cells. Further aspects include the cell product for therapeutic of autoimmune and/or neurological disease. —X— III Il © Il Ot 01 (57) f .r1 method 0 ----. active GC enitor 1-1 ei stem cells comprising non-hematopoietic C [Continued on next page] WO 2018/039810 Al MIDEDIMOMMIDIREIHNIMIINIMMEOMIONVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))