Patent SG-11201900692W-A (SG)
Title: Donepezil transdermal delivery system
Inventor: LEE EUN SOO
IPC: A61P25/28
Filed: 2017-07-26
Abstract: transdermal patch (larger) C.) 30 transdermal patch (smaller) E 20 10 3 4 N co O co O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIP0 I PCT onion OH oI0III11010111OHHDIDurnoff ow (10) International Publication Number WO 2018/022817 Al (51) International Patent Classification: A61K 31/445 (2006.01) A61P 25/28 (2006.01) A61K 9/70 (2006.01) (21) International Application Number: PCT/US2017/044050 (22) International Filing Date: 26 July 2017 (26.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/367,542 27 July 2016 (27.07.2016) US 62/367,502 27 July 2016 (27.07.2016) US 62/423,133 16 November 2016 (16.11.2016) US 62/444,745 10 January 2017 (10.01.2017) US 62/444,763 10 January 2017 (10.01.2017) US 62/457,794 10 February 2017 (10.02.2017) US 62/504,408 10 May 2017 (10.05.2017) US 62/504,391 10 May 2017 (10.05.2017) US (71) Applicant: CORIUM INTERNATIONAL, INC. [US/US]; 235 Constitution Drive, Menlo Park, California 94025 (US). (72) Inventors: LEE, Eun Soo; 2575 Hampton Avenue, Red- wood City, California 94061 (US). JAIN, Amit K.; 825 Carino Terrace, Milpitas, California 95035 (US). SINGH, Parminder; 5504 Alvelais Drive, Union City, California 94587 (US). (74) Agent: MOHR, Judy M. et al.; 500 North Capitol Street, N.W., Washington, District of Columbia 20001-1531 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: DONEPEZIL TRANSDERMAL DELIVERY SYSTEM Days at Steady State (Week 5) FIG. 5A (57) : A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises drug reservoir layer comprised of an acrylate copolymer, glycerine, and donepezil base generated in situ by reaction of donepezil HC1 and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent that is bioequivalent to administration of the therapeutic agent orally. [Continued on next page] WO 2018/022817 Al IMEDIMOMMIDIRE10101011010H1HOIDERVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))