baber/WOPTO huggingface dataset:
Patent NO-830776-L (NO)
Inventor: OESTLUND GUNNAR
IPC: B01D35/16
Filed: 1983-03-07
Abstract: A filter, especially suitable for liquids which are difficult to filter and comprising a closed cylindrical filter container (1) having an inlet (5) for the liquid to be filtered and an outlet (7) for the filtrate and enclosing a filter unit (3) comprising one or more filter elements (13-15) which are mounted substantially concentrically inside the filter container (1). At one end, preferably the bottom end in case of vertically standing containers, the filter container has a bottom cover (2) which can be opened, and the filter element or elements (13-15) are mounted so that they can be extracted from and be retracted into the filter container (1) through said cover (2). The filter unit may comprise several filter elements (13-15) formed as separate units and mounted concentrically inside each other. The filter elements are designed so that an inner filter element over a collar (16-18) carries and is sealed against the adjacent outer filter element. Each filter element comprises an annular cylinder chamber, in which the filtrate is collected and can be removed through collection chamber (45) from which the filtrate is removed from which
Patent NO-833397-L (NO)
Inventor: LEOPARDI FRANCESCO
IPC: G01N33/48
Filed: 1983-09-21
Abstract: In an apparatus for measuring the rate of erythrosedimentation of the blood a bell mouthed test tube is provided, having a cylindrical part in which a calibrated and graduated sealing tube, topped with an overflow sleeve for the excess blood, slides. This overflow sleeve allows an automatic filling with blood of the calibrated tube independently from the care taken in the filling of the tapered test tube.
Patent NO-850020-L (NO)
Inventor: UMPLEBY JAFFREY DAVID
IPC: C08L57/04
Filed: 1985-01-03
Abstract: A crosslinkable composition comprising a silyl modified ethylene (co)polymer, a defined phosphorus or antimony compound and optionally a silanol condensation catalyst. The silyl modified polymer has hydrolysable silane groups introduced therein by copolymerisation, grafting or transesterification. The phosphorus or antimony compound (e.g. tributyl phosphite) reduces premature crosslinking during extrusion of the composition.
Patent NO-870597-L (NO)
Inventor: COLMAN DEREK ALAN
IPC: B04C/
Filed: 1987-02-16
Abstract: PCT No. PCT/AU86/00173 Sec. 371 Date Feb. 27, 1987 Sec. 102(e) Date Feb. 27, 1987 PCT Filed Jun. 17, 1986 PCT Pub. No. WO86/07548 PCT Pub. Date Dec. 31, 1986.This invention is about a cyclone separator. This separator may find application in removing a lighter phase from a large volume of a denser phase such as oil from water, with minimum contamination of the more voluminous phase. Most conventional cyclone separators are designed for the opposite purpose, that is removing a denser phase from a large volume of lighter phase, with minimum contamination of the less voluminous phase. In our case, a typical starting liquid-liquid dispersion would contain under 1% by volume of the lighter (less dense) phase, but it could be more.
Patent NO-873467-L (NO)
Inventor: JONSSON SVEN
IPC: H01J29/86
Filed: 1987-08-18
Abstract: A method and an apparatus for reducing of and diverting radiation from all kinds of radiation emitting surfaces like viewing screens, TV screens, chassis, apparatus boxes etc. whereby an electrically conducting current diverting means (11), for instance a coil of stainless steel, is applied in direct contact with the radiation emitting surface (9) and is connected to earth (12), and whereby a fluid layer containing film or foil or a mass is applied directly to the radiation emitting surface (9) and the diverting means (11), said fluid layer or mass comprising a salt of electrolytic type, and in which the mass is of the type which forms a surface skin or becomes dried right through when being exposed to air, and said layer or mass being electrically conducting even in such dried state, and whereby the apparatus is ready for being used when said mass has formed a skin or has become dried. The current diverting means can be applied after the application of the electrolytic layer or mass. The fluid layer or covering mass preferably is a salt of an acid and an alkali metal or calcium, for instance sodium or potassium lauryl ether sulphate or calcium lauryl ether sulphate.
Patent NO-875251-L (NO)
Title: Framgangsmaate for kjoeling av et smeltet medium.
Inventor: DOSAJ VISHU DUTT
IPC: C21B7/10
Filed: 1987-12-16
Abstract: Ei forbedring av prosesser hvor saeltede Materialer handteres ved forhayede temperaturer, er beskrevet. Forbedringa består i bruk av ei polyorganosiloksan-vske son kjeleaediua i stedet for vann. Denne forbedringa eliainerer de sikkerhetefårer toa er forbundet ned daapeksplosjoner sos kan inntreffe når vann kanner i kontakt ned sneltede naterialer ved haye temperaturar.
Patent NO-881758-L (NO)
Inventor: SCHWARTZ WILLIS T JR
IPC: C07C65/24
Filed: 1988-04-22
Abstract: Diether diphthalic anhydrides are prepared by reacting fluorophthalic anhydride with an aromatic dihydroxy compound in the presence of an alkali metal fluoride and a polar, aprotic solvent.
Patent NO-884171-L (NO)
Title: Katalytisk omdanningsprosess.
Inventor: LEWIS JEFFREY MICHAEL OWEN
IPC: B01J8/22
Filed: 1988-09-20
Abstract: En fremgangsmåte for katalytisk omdanning av et råstoff til et produkt omfattende kontakt mellom råstoffet og en krystallinsk mikroporøs tredimensjonal fast katalysator med evnen til å fremme omdanning ved betingelser som bevirker omdanning av råstoffet til produktet idet den faste katalysator er tilstede i en oppslemming med en væske forskjellig fra råstoffet eller i en væske der produktet er mindre reaktivt enn råstoffet.
Patent NO-893361-L (NO)
Inventor: HOPPERDIETZEL SIEGFRIED
IPC: B60S1/48
Filed: 1989-08-22
Abstract: The invention relates to a connection or distribution piece for heatable hoses. The hose heating is carried out by means of heating conductors which are arranged running longitudinally in or on the hose wall. The connection piece consists of a connection element, inserted into the hose internal diameter, and insulation. According to the invention, the insulation is a sleeve tube (1), divided in the longitudinal axis, whose two half shells (11, 12) can be fixed on one another via connection means (111, 112, 121, 122), with the free ends (21) of the hoses (2) to be connected covered. On the outer surface of the connection element (3), there are integrally formed material steps (31, 32), increasing in thickness in the insertion direction, distributed on the circumference in the region of the insertion into the hose internal diameter (22). These material steps (31, 32) enter into a clamping effective connection with compression webs (113, 114, 123, 124) which are integrally formed on the inner circumference of the half shells (11, 12) when the hose (2) is retained on the connection element (3). <IMAGE>
Patent NO-900692-L (NO)
Inventor: ROGER CARINE
IPC: A45D40/16
Filed: 1990-02-13
Abstract: Container for dispensing solid products (22), characterised in that it comprises a tubular body (1) provided, substantially in its central section, with a piston (9) comprising operating means (17, 171, 172, 23) which are accessible from outside of the body (1) and closed by a removable cover (5), the said piston (9) delimiting an opening (11a) for the insertion of the product (22) filling at least one internal chamber (2, 2a, 2b, 2c, 2d) of the said body and means of closure (17a, 21, 24, 28, 29) being provided to prevent the flow of the product (22) after filling the chamber (2). 
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Patent NO-913136-L (NO)
Inventor: USHIO KAZUMICHI
IPC: A61K31/538
Filed: 1991-08-12
Abstract: A composition for eye drops comprising as a main effective component 3,4-dihydro-2,8-diisopropyl-3-thioxo-2H-1,4-benzoxadine-4-acetic acid or a pharmaceutically acceptable salt thereof and cyclodextrin is disclosed.
Patent NO-921156-L (NO)
Inventor: PICK JOHN HENRY
IPC: A61K31/426
Filed: 1992-03-24
Abstract: The invention concerns a 4-aryl-thiazole or imidazole derivative having the formula I <CHEM>  wherein X is O or NOH,  Y is S or NR3, Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl, R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF3, NO2, and O-ALK-NR1R2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R1 and R2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, and R3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded. The compounds according to the invention increase the sensitivity of cardiac myofibrils to calcium and possess phosphodiesterase inhibitory activity and bronchodilator activity, and are useful for the treatment of patients suffering from heart failure and asthma.
Patent NO-921201-L (NO)
Title: Skuddsikre artikler samt fremgangsmaate ved fremstilling derav
Inventor: KINSLEY JR HOMAN B
IPC: F41H/
Filed: 1992-03-27
Abstract: En skuddsikker artikkel omfatter en agglomerert bane av to typer enkeltfibre. Den første type er en fiber dannet fra et polyolefinfilament, som for tilfelle av poly-etylenfilament har en vektmidlere molekylvekt på minst 500,000, en bruddmodul på minst 300 g/denier og en styrke på minst 15 g/denier og for tilfelle av poly-propylenfilament en vektmidlere molekylvekt på minst 7 50,000, en bruddmodul på minst 160 g/denier og en styrke på minst 8 g/denier. Den andre type er en hoydensitet polyolefinfiber med den midlere fiberlengde vesentlig kortere enn for den første type. Artikkelen har en tilstrekkelig tykkelse til å absorbere et prosjektils energi.
Patent NO-924953-L (NO)
Inventor: BAXTER ANDREW JOHN GILBY
IPC: C07C229/16
Filed: 1992-12-21
Abstract: PCT No. PCT/GB91/00980 Sec. 371 Date Dec. 10, 1992 Sec. 102(e) Date Dec. 10, 1992 PCT Filed Jun. 18, 1991 PCT Pub. No. WO92/00276 PCT Pub. Date Jan. 9, 1992.Angiotensin converting enzyme inhibitors have the formula Z(CH2)nCHR1COOCHR2COOH in which Z is -SR3, -COCHR4NHCOR5,   <IMAGE>    or -NHCHR7COOH, R4, R5, R6, and R7, which may be the same or different, are each phenyl or alkylphenyl C7-12, R4 is hydrogen, alkyl C1-6, NHR8 or (CH2)pR9, R2 is (CH2)mXR10, alkyl C1-6 optionally substituted by a saturated 5- or 6-membered carbocyclic or heterocyclic ring, alkylhalo C1-6, alkylcyano C1-6, or alkyl phenyl C7-12, the phenyl being optionally substituted by NO2 or NH2, X is O, S(O)q, C=O or NR11, and R10 is alkyl C1-6, alkylhalo C1-6, alkoxy C1-6, alkoxy C1-6 substituted by halogen, alkanoyl C1-6, S(O)rR12, NR13R14, phenyl, alkylphenyl C7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring, n is an integer from 0 to 6, m and p, which may be the same or different, are each an integer from 1 to 6, R9 is hydrogen, SR15 or phenyl optionally substituted by OR16, R3 and R15, which may be the same or different, are each hydrogen or alkanoyl C1-6, R8 is hydrogen or COOR17, q and r, which may be the same or different, are each 0, 1, or 2, R11, R13, R14, R16, and R17, which may be the same or different, are each hydrogen or alkyl C1-6, and R12 is hydrogen, alkyl C1-6 or phenyl. The compounds, and salts thereof, are useful as vasodilators.
Patent NO-930305-L (NO)
Inventor: LOGOTHETOU-RELLA HELEN
IPC: A61P31/18
Filed: 1993-01-29
Abstract: The invention relates to the use of inhibitors of neutral Ca<2+> dependent proteinases (CANPs) and their pharmaceutically acceptable addition salts or their active subunits in the field of tumour therapy, especially cancer therapy, viral diseases therapy, AIDS therapy and contraception. The inhibitors can especially be used against protease bound glycosaminoglycan-substrate dependent tumours, viral diseases and contraception by selective malignant cell killing, viruses and spermatozoa killing and inhibiting of nuclear vlimmata in a host-parasite cell system involving common protease bound substrate. The inhibitors are heatstable, tetrameric proteins at neutral pH, approximatively 240 KDa, destroyed with trypsin. The pharmaceutical compositions may be prepared in a manner known per se, with carriers or additives commonly used in the pharmaceutical industry.
Patent NO-930524-L (NO)
Inventor: GLANSK LEIF
IPC: F24D19/08
Filed: 1993-02-15
Abstract: A combined control and regulating valve (1) having a housing (2) with an inlet (3) and an outlet (4) as well as a partition (5) between said inlet and outlet and having a seat (6) designed for an interaction with a main valve body (7), which is adjustable from outside. To said inlet and said outlet are connected a measuring nipple each (50 and 74, respectively) via a bore (30, 31 and 40, 41 respectively) for the measurement and the control of temperature and/or pressure. One of the measuring nipples is designed as a multiple function nipple (50) having a cut-off-valve permitting tapping and filling of the medium, which is to be controlled/regulated. In order to enhance reliability in operation, to provide even more precise and reliable measuring results, to reduce the risk of clogging of the cavities leading to the measuring nipples, to reduce costs for manufacturing and/or fitting, to provide preconditions for various conditions of operation and for partial changes as well as for being able to affect other valve properties, like sealing properties and use of differently designed or dimensioned valve bodies, at least one bore (30, 31) is extended axially to communicate with a so extended portion (110) with a zone of the medium channel (73) downstream of said seat (6) via an area immediately above said valve body (7) or around said seat (6) by means of a casing provided with a groove.
Patent NO-930891-L (NO)
Title: Nye diarylsulfonamider
Inventor: MOHANEDI FARIBORZ
IPC: C07D307/82
Filed: 1993-03-11
Abstract: Bezofuransulfonamld-, benzotlofensulfonamid- og indolsulfonamidderivater av formelen:. hvor :. B er -0- eller -S-,. Rer halogen, C-Calkyl eller hydrogen, og. Rer halogen, C^- Co alkyl eller trifluormetyl,. eller et farmasøytisk akseptabelt salt eller solvat derav.Disse forbindelsene er egnet for behandling av mottakelige neoplasmer i pattedyr. Det beskrives også visse nye benzofuransulfonamid- og benzotiofensulfon-amidderivater og deres farmaseyti ske preparater. Videre beskrives fremgangsmåter for fremstilling av forbind-e1 sene.
Patent NO-931463-L (NO)
Title: Fremgangsmaate til aa styre faststoffer som foelger hydrokarbonproduksjonen fra underjordiske formasjoner
Inventor: HEALY JOHN CHAPIN
IPC: E21B43/267
Filed: 1993-04-21
Abstract: En fremgangsmåte for gruspakking av en brønnboring (12) er anvist der en resinbelagt sand eller "grus" benyttes. Først perforeres brønnboringen (12) ved det produserende Intervall på en måte som er tilstrekkelig til å frakturere hydraulisk formasjonen (10). Etterpå fraktureres formasjonen (10) hydraulisk via et fraktureringsfluid som Inneholder en resinbelagt sand. Under denne fraktureringsoperasjon proppes en resulter- ende fraktur (20) med den resinbelagte sand. Det frakturerende fluid pumpes ned brønnboringen (12) inntil "screen out" skjer ved perforeringene l brønnboringen. Den resinbelagte sand lar man være igjen i frakturen (20), perforeringene (18) og brønnboringen (12) Inntil en permiabel, porøs, konsolidert masse er dannet. Etter at massen er dannet, fjernes overskudds konsolidert sand fra brønnboringen (12). Når forma- sjonen (10) er fremstilt, holdes formasjonsfaststoffene av den konsoliderte masse i frakturen og perforering- ene. I en alternativ utførelse holdes trykket i det frakturerende fluid under fraktureringstrykket.
Patent NO-943514-L (NO)
Title: Sprutskjerm for beltekjöretöy
Inventor: ALAVA HANNU
IPC: B62D55/088
Filed: 1994-09-21
Abstract: Oppfinnelsen angår en sprutskjerm (7) for et beltekjøretøy omfattende en belte- enhet (1,2,3) med en ramme (1), et belte- hjul (3), eventuelle hjelpehjul (11) og et belte (2), hvor sprutskjermen (7) er plas- sert i umiddelbar nærhet av beltet (2) og er festet til belte-enheten (1,2,3) ved hjelp av en stette (5,5a). På den .side som vender mot beltet (2) omfatter sprut- sk j ermen fortrinnsvis to glideskinner (8,Sa) som forløper i lengderetningen av beltet (2), det vil si av sprutskjermen (7). Beltet (2) er innrettet til å gli mot glideskinnene (8,8a) når sprutskjermen (7) berører beltet (2) som følge av belte- enhetens (1,2,3) bevegelser opp og ned under kjøring.
Patent NO-943540-L (NO)
Title: Antivirale peptider
Inventor: GREENGRASS COLIN WILLIAM
IPC: A61K31/415
Filed: 1994-09-23
Abstract: Forbindelse av formel (I) o R2 R4 HO R3 o og farmasøytisk akseptable salter derav og bioprekursorer for dette, hvor R1 er 0,-C^alkyl, C3-C8-cykloalkyl, aryl, heterocyklyl eller CONR9R10; R2 er C^Cg-alkyl, C3-C8-cykloalkyl-(C1-C4)-alkyl, aryl- (C^-C^-alkyl eller heterocyklyl-^-C^-alkyl; R3 er C^Cg-alkyl, C3-C8-cykloalkyl, Cg-Ca-cykloalkyl-^-C^-alkyl, aryl-^-C^alkyl, aryl-CCg-C^-alkenyl, heterocyklyHC^-C^-alkyl eller heterocyklyl- (Cj-C^-alkenyl; R4 er 0,-Cg-alkyl, C3-C8-cykloalkyl, aryl eller heterocyklyl; hver av R5, R6, R7 og R8 er uavhengig av hverandre H, C1-C6-alkyl eller C3-C8-cykloalkyl, eller R5 og R6 eller R7 og R8 kan bli slått sammen for å danne en 3- til 8-leddet karbocyklisk ring; X er en 4- til 10-leddet mono- eller bicyklisk heterocyklisk gruppe inne- holdende karbonringatomer og ett ringnitrogenatom via hvilket gruppen er bundet til den hosliggende karbonylgruppe; gruppen kan være mettet eller delvis umettet og i tillegg til -(CR7R8)m-Het-substituenten kan den være substituert med opp til fire ytterligere substituenter, uavhengig valgt fra F, C^Cg-alkyl, C3-C8-cykloalkyl, OR11 eller NR9R10; Het er en imidazolyl- eller triazolylgruppe hvorav hver even- tuelt kan være substituert med C1-C6-alkyl, C3-C7-cykloalkyl, NR9R10 eller CONR9R10; hvor hver av R9 og R10 uavhengig av hverandre er H, C^-Ce-alkyl eller C3-C8-cykloalkyl eller R9 og R10 kan bli slått sammen for å danne, med nitrogenet til hvilket de er bundet, en 4- til 8-leddet nitrogeninneholdende heterocyklisk gruppe; R11 er H, C^-Cg-alkyl eller C3-C8-cykloalkyl; n og m er hver uavhengig av hverandre O, 1 eller 2, hvor enhver alkyl- eller cykloalkylgruppe Inkludert l ovenfor nevnte definisjoner eventuelt kan være fullstendig eller delvis substituert med fluor; er inhibitorer for retrovirale proteaser med anvendelighet for behandling og profylakse av humane retrovirale infeksjoner.
Patent NO-953353-L (NO)
Inventor: HITCHCOCK JANICE MARY
IPC: A61P25/28
Filed: 1995-08-25
Abstract: PCT No. PCT/US94/01009 Sec. 371 Date Dec. 18, 1995 Sec. 102(e) Date Dec. 18, 1995 PCT Filed Jan. 27, 1994 PCT Pub. No. WO94/19349 PCT Pub. Date Sep. 1, 1994A method of attenuating a cognitive deficit in a patient in need thereof comprising administering to the patient a xanthine derivative.
Patent NO-960325-L (NO)
Inventor: FRITZ HANS
IPC: C07K14/81
Filed: 1996-01-26
Abstract: PCT No. PCT/EP94/02445 Sec. 371 Date Jan. 25, 1996 Sec. 102(e) Date Jan. 25, 1996 PCT Filed Jul. 25, 1994 PCT Pub. No. WO95/03333 PCT Pub. Date Feb. 2, 1995The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibtor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells transformed with such vectors, to the recombinant production of the inibitors, to pharmaceutical compositions containing the novel inhibitor molecules, and to their use in diagnosis and therapy.
Patent NO-960777-L (NO)
Title: Anvendelse av N-alkylerte 1,4-dihydropyridin dikarboksylsyreestere som medikamenter
Inventor: ZAISS SIEGFRIED
IPC: C07D211/90
Filed: 1996-02-26
Abstract: Oppfinnelsen angår anvendelse av delvis kjente N-alkylerte l,4-dlhydropyridin dikarboksylsyreestere med generell formel (I), hvori R1 blant annet står for hydrogen, nitro, cyano eller trlfluormetyl, R2 står for hydrogen, halogen, nitro eller hydroksy, R3 står for hydrogen eller cyano, og R2 og R3 kan sammen danne en tllkondensert benzoring, R4 og R5 er like eller forskjellige og kan bety alkyl med inntil 8 karbonatomer , og kan være substituert, R^ står for rettkjedet eller forgrenet alkyl med inntil 6 karbonatomer eller cykloalkyl med 3 til 7 karbonatomer. Forbindelsene kan anvendes som antiatherosklerotlske medikamenter, særlig for å forhindre restenose etter angioplasti og kirurgi l blodkar.
Patent NO-963624-L (NO)
Title: Kretslöp til strömmåling samt anvendelse derav
Inventor: NIELSEN ERLING
IPC: G01R19/00
Filed: 1996-08-30
Abstract: Ved måling av strøm i en leder (6) tilkobles en differentialforsterkers (1) to innganger lederen i to punkter (7, 8), som har en passende avstand. På denne måte unngås tapsgivende elementer ved målingen, samt bruk av strømomsluttende elementer. Strømforsyningen til differentialforsterkeren uttas symmetrisk i forhold til lederens potentiale. I tillegg til strømmen måles lederens spenning, og så vel som strøm som spenning tilføres A/D omformer. De digitaliserte signaler tilføres en beregningsenhet (5), hvilken er innrettet til å beregne lederens øyeblikkseffekt, øyeblikkesenergi, kvadratet på lederens strøm, strømmens kurveform, samt frekvensinnhold. Ovennevnte måleoppstilling er velegnet til styring av releer, sikringsutkoblinger, overstrømsbestemmelser samt som forbruksmåler til motorstyringer, og forsterkerkarakteristikk-overvåkning.
Patent NO-971875-L (NO)
Inventor: BROEMME DIETER
IPC: C07K16/40
Filed: 1997-04-23
Abstract: The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.
Patent NO-975238-L (NO)
Title: Muskeltrofisk faktor
Inventor: GRABSTEIN KENNETH H
IPC: A61K38/27
Filed: 1997-11-14
Abstract: Preparater og fremgangsmåter for stimulering av muskelvekst eller differensiering hos en vertebrat. Slike preparater omfatter en muskeltrofisk mengde av interleukin-15 og kan anvendes for å behandle ulike tilstander, deriblant inaktivitets- atrofi, svinn av vev, ulike aldersrelaterte forstyrrelser, bivirkninger av diabetes, deriblant glukoseintoleranse, i tillegg til muskulaer dystrofi, rhabdomyosarkom og kongestiv hjertesvikt. Preparatene og fremgangsmåtene ifølge oppfinnelsen kan brukes innen landbruket for økning av effektiviteten ved kjøtt- og melkeproduksjon fra gårdsdyr.
Patent NO-975493-L (NO)
Inventor: SUGUMI HIROYUKI
IPC: C07D491/16
Filed: 1997-11-28
Abstract: Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: <CHEM> wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula -e-f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity.