Patent SG-11201809469Q-A (SG)
Title: [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl] (1h-1,2,3-triazol-4-yl)methanones
Inventor: KOPPITZ MARCUS
IPC: C07D487/08
Filed: 2017-05-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 111010101111101011111 0 01 010 1101 OH 0101111111011011# Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/202817 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, CO7D 487/08 (2006.01) A61P 29/00 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 31/498 (2006.01) A61P 35/00 (2006.01) A61P 15/00 (2006.01) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/EP2017/062359 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (22) International Filing Date: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 23 May 2017 (23.05.2017) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (25) Filing Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English (30) Priority Data: Declarations under Rule 4.17: 16171538.8 26 May 2016 (26.05.2016) EP — as to applicant's entitlement to apply for and be granted a 16178891.4 11 July 2016 (11.07.2016) EP patent (Rule 4.1700) (71) Applicant: BAYER PHARMA AKTIENGESEL- Published: LSCHAFT [DE/DE]; Milllerstr. 178, 13353 Berlin (DE). — with international search report (Art. 21(3)) (72) Inventors: KOPPITZ, Marcus; ElsenbruchstraBe 34A, 13467 Berlin (DE). SIEBENEICHER, Holger; Krupp- strasse 18, 10557 Berlin (DE). STEUBER, Holger; Han- noversche Strasse 19a, 10115 Berlin (DE). TER LAAK, Antonius; Hedwigstrasse 11, 12159 Berlin (DE). NUBBE- MEYER, Reinhard; Moorweg 96, 13509 Berlin (DE). ROTTMANN, Antje; Schneehompfad 11A, 13089 Berlin (DE). IRLBACHER, Horst; Winsstrasse 47, 10405 Berlin (DE). BADER, Benjamin; Hillmannstrasse 14, 13467 Berlin (DE). PETERS, Michaele; Heinrich-Roller Strasse 1, 10405 Berlin (DE). WAGENFELD, Andrea; Weddin- genweg 64, 12205 Berlin (DE). TEREBESI, Ildiko; Re- ichensteiner Weg 5, 14195 Berlin (DE). Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (74) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (81) Title: [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]0CT-3-YL] (1H-1,2,3-TRIAZOL-4-YL)METHANONES (54) 1-1 (57) : The present invention covers [8-(phenylsulfony1)-3,8- diazabicyclo[3.2.1]oct-3-y1R1H-1,2,3-triazol-4-yl)methanone compounds of general for- 1-1 mula (I) in which R 1 , R, R , R 2 3 4 and R 5 are as defined herein, methods of preparing said GC e , ' ei 110 R 4 compounds, intermediate compounds useful for preparing said compounds, pharmaceuti- cal compositions and combinations comprising said compounds and the use of said com- N—S ` , 0 pounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of IN I I disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic N 0 ,1 N ii \ (I) disorders, or inflammatory disorders as a sole agent or in combination with other active 0 ei 'N ingredients. H C