baber/WOPTO huggingface dataset:
Patent FI-970446-A0 (FI)
Inventor: ROSENBERG STEVE
IPC: A61K38/00
Filed: 1997-02-03
Abstract: Compounds of the invention inhibit urokinase plasminogen activator:   <IMAGE>   where R1 is lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, aryl-alkenyl, aryl-alkynyl, aryl-cycloalkyl, unsubstituted or substituted with 1-3 halo, OH, NH2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, CN or NO2; R2 is aryl or aralkyl, unsubstituted or substituted with 1-3 halo, OH, NH2, CN, NO2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl; R3, R5 and R9 are each independently H or lower alkyl; R4 is   <IMAGE>    where R6 and R7 are each independently H, OH, NH2, CN, NO2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl, and n and m are each independently an integer from 1 to 3 inclusive; and pharmaceutically acceptable acid addition salts thereof.
Patent IL-61224-A0 (IL)
Title: 10-bromosandwicine and 10-bromoiso-sandwicine, their preparation and their use in synthesis
IPC: A61P9/06
Filed: 1980-10-07
Abstract: 10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.
Patent IL-68283-A0 (IL)
Title: 4h-thiopyrans,their preparation and pharmaceutical compositions containing them
IPC: A61P9/00
Filed: 1983-04-01
Abstract: 1. Thiopyrans of the general formula (I)  see diagramm : EP0091051,P9,F2  in which R represents phenyl, naphthyl, furyl, pyrryl or pyridyl, these rings optionally containing 1, 2 or 3 identical or different substituents from the group comprising alkyl, alkenyl, alkinyl, alkoxy, alkylene, alkylenedioxy, alkylamino, each having up to 4 carbon atoms, phenyl, halogen, trifluoromethyl, trifluoromethoxy, nitro, cyano or azido, R**1 , R**3 and R**4 are identical or different and each represent hydrogen, an alkyl radical with up to 6 carbon atoms or one of the radicals mentioned under R, it being possible for R**4 also to represent a single bond to R with the formation of a 6- to 7-membered lactone ring ; R**2 represents hydrogen, an alkyl radical with up to 4 carbon atoms, phenyl or aminoalkyl with up to 4 carbon atoms, and X represents O, S or -NH-, and their pharmaceutically acceptable acid addition salts.
Patent IL-74369-A0 (IL)
Title: Process for making substituted phenoxycycloalkanols
IPC: C07C43/253
Filed: 1985-02-19
Abstract: A process for making a compound having the formula R-O-R<1>OH where R is phenyl or phenyl substituted with C1-C4 alkyl, C1-C4 alkoxy or methylenedioxy; and R<1> is C5-C6 cycloalk-1,2-ylene or C5-C6 cycloalk-1,2-ylene substituted with C1-C4 alkyl or C1-C4 alkoxy, useful as an intermediate in the manufacture of organic sulfite esters, is disclosed. In this process a compound of the formula ROH, where R has the meanings given above is reacted with a compound selected from the group consisting of cyclopentene oxide, cyclohexene oxide, cyclopentene oxide substituted with C1-C4 alkyl, C1-C4 alkoxy or vinyl and cyclohexene oxide substituted with C1-C4 alkyl, C1-C4 alkoxy or vinyl.
Patent IL-81972-A0 (IL)
Title: Copolymerization catalyst compositions
IPC: B01J27/14
Filed: 1987-03-23
Abstract: Novel catalyst compositions, characterized in that they are based upon 
 
  a) a palladium compound, 
  b) a non-noble transition metal salt of an acid with a pKa of less than 2, provided that the acid is not a hydrohalogenic acid, or a mixture of such a salt and such an acid, 
  c) a bidentate ligand of the general formula R<1>R<2>-M-R-M-R<3>R<4>, wherein M represents phosphorus, arsenic or antimony, R<1>, R<2>, R<3> and R<4> represent hydrocarbyl groups which may or may not be substituted with polar groups and R represents a bivalent organic bridging group having at least two carbon atoms in the bridge, and 
  d) a quinone, if desired.
Patent IL-84006-A0 (IL)
Title: Cloning and expression of the 47-kilodalton antigen of treponema pallidum
IPC: C12R1/19
Filed: 1987-09-27
Abstract: Monoclonal antibodies directed against the 47 kDa major outer membrane surface immunogen of virulent Treponema pallidum were used to select E. coli recombinant clones expressing the 47 kDa immunogen. The phenotype of the clones was dependent on the presence of recombinant plasmid in the host cell. Southern hybridization revealed that the cloned T. pallidum DNA sequence was an accurate representation of the T. pallidum genomic DNA arrangement. Purified IgG from rabbits experimentally infected with T. pallidum and human secondary syphilitic sera specifically reacted with the clones while normal human serum or IgG from normal rabbit serum did not. Results of Southern hybridization indicated that a homologous 47 kDa immunogen gene was absent in at least 4 species of nonpathogenic treponemes tested, as well as from total rabbit genomic DNA. Rabbit anti-T. phagedenis biotype Reiter (treponemal nonpathogen) antiserum and a monoclonal antibody directed against a "common" treponemal determinant were unreactive with the clones. Western blotting and radioimmunoprecipitation experiments with specific monoclonal antibodies revealed that the recombinant (E. coli) and native (T. pallidum) forms of the antigen had identical electrophoretic mobilities. The availability of recombinant 47 kDa immunogen provides a new opportunity for biochemical analysis of the protein, structure-function studies, examination of its role in microbial pathogenesis, and assessment of its diagnostic and vaccinogenic potentials.
Patent IL-95872-A0 (IL)
Title: 24-homo vitamin d derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IPC: A61K31/59
Filed: 1990-10-02
Abstract: 24-Homo-vitamin D derivatives of the formula I <IMAGE>  are described, in which   R<1> is a hydrogen atom, a hydroxyl or an acyloxy group with 1 to 8 carbon atoms, R<2> and R<3> are, independently of one another, a linear or branched alkyl group having 1 to 4 carbon atoms, a trifluoromethyl group or together are a saturated carbocyclic ring which is formed with carbon atom 25 and has 3 to 9 carbon atoms, R<4> and R<5> are, independently of one another, a hydrogen atom or an acyl group having 1 to 8 carbon atoms, and   A and B are each a hydrogen or together are a second bond, and   n is 1, 2, 3, 4 or 5 and to a process for their production, pharmaceutical compositions containing them and their use for the preparation of medicines. The compounds have proliferation-inhibiting and cell-differentiating action.
Patent IL-96555-A0 (IL)
Title: Process and apparatus for de-polluting circulated air
IPC: A61L9/015
Filed: 1990-12-05
Abstract: A process that deals with the sick building syndrome and building related illnesses, and solves volatile organic compound and biological pollution problems associated with large confined areas through which forced air is circulated, and the area is utilized for sociatary functions or activities, e.g., habitation by animals and/or equipment or other materials sensitive to pollutants or contaminants utilized in a societary activity within such areas, which comprises treating the circulating air in an air treatment zone (i) with ozone in a depollution catalytic zone removed from contact with humans and/or the sensitive equipment to remove pollutants and contaminants from the air, and thereafter, (ii) the treated air is treated to remove ozone before being returned to the cycle flow within the confined area located outside of the air treatment zone. <IMAGE>
Patent FI-20012291-A0 (FI)
IPC: D21F1/48
Filed: 2001-11-23
Abstract: Paper or cardboard web forming apparatus has a double wire section having a first wire loop having a dewatering box, and two successive dewatering zones. To achieve more effective water drainage in a second dewatering zone, the bottom of the dewatering box forms a fraction line consisting of straight portions and edges between them, over which the web between the two wires moves.  Paper or cardboard web forming apparatus comprises a double wire section consisting of a first wire loop formed by a first wire, a second wire loop formed by a second wire, and at least one headbox, from which the fibrous web suspension can be fed into the space between the wire loops. The first wire loop is provided with a dewatering box placed above the wire and arranged to drain water from the fibrous suspension between the wire loops via the bottom of the dewatering box and through the first wire. The apparatus has two successive dewatering zones, where the direction of web movement in the area of the first dewatering zone is away from the dewatering box and the runs of each wire loop are straight, while in the area of the second dewatering zone the direction of the web movement is towards the dewatering box and water drainage from the fibrous suspension is arranged to take place in the direction towards the dewatering box. To achieve more effective water drainage in the second zone, the bottom (11) of the dewatering box forms a fraction line consisting of straight portions and edges between them, over which the web between the two wires moves.
Patent FI-20031735-A0 (FI)
Inventor: VUORIMIES TIMO
IPC: D21G1/00
Filed: 2003-11-27
Abstract: Vibration is prevented in a multi-nip calender ( 1 ) or an array of multi-nip calendars. Each calender has a lower roll ( 3; 40 ), an upper roll ( 3; 30 ) and two or more intermediate rolls. A fiber web is conveyed through the closed roll nips of the calenders. The intermediate rolls ( 3 ) have load-relieving apparatus and the upper roll ( 3; 30 ) and the lower roll ( 3; 40 ) have loading apparatus, while loading apparatus are connected to the lower roll ( 3; 40 ) and/or the upper roll ( 3; 30 ) for loading these rolls from the outside in a direction parallel with the calender plane. The running parameters ( 9 ) influencing the calendering impulse of one or more selected roll nips (N) are intermittently or continuously changed, such that the overall calendering impulse ( 9 ) of the calender or calender array and/or the quality variables ( 21 ) of the fiber web remain substantially constant and/or within predetermined limits.
Patent FI-20085628-A0 (FI)
Inventor: KALLIO PASI
IPC: G01F1/7086
Filed: 2008-06-23
Abstract: Method for inspecting a microfluidic system, where an imaging means is used for detecting fluid flow changes in the microfluidic system. The fluid flow in the microfluidic system is inspected by means of machine vision.
Patent IL-100621-A0 (IL)
Title: Tetrazole derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/42
Filed: 1992-01-09
Abstract: Tetrazole derivatives of the formula   <IMAGE> (I)  in which R1 denotes a saturated or unsaturated, straight-chain or branched (C1-C6) alkyl radical and R2 denotes methyl or ethyl, and their pharmaceutically usable salts.
Patent IL-103078-A0 (IL)
Title: Therapeutic compounds
IPC: A61K31/00
Filed: 1992-09-07
Abstract: PCT No. PCT/EP92/02067 Sec. 371 Date Jul. 5, 1994 Sec. 102(e) Date Jul. 5, 1994 PCT Filed Sep. 3, 1992 PCT Pub. No. WO93/06098 PCT Pub. Date Apr. 1, 1993   <IMAGE>  (I)   <IMAGE>  (Ya)   <IMAGE>  (Yb)  Compounds of formula (I) wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy or (b) a thienyl group; and Y is of formula (Ya) or (Yb) where A and B are 0, 1 or 2, D and E are 0 or 1, F is 0-3 and D+E+F=1-3, Z is 0, 1 or 2, R1 and R2 are H or alkyl or form a ring, and R3 is C1-C4 alkyl, C3-C6 cycloalkyl or optionally substituted phenyl or benzyl, are antimuscarinic bronchodilators useful for treating chronic obstructive airways disease or asthma.
Patent IL-103658-A0 (IL)
Title: Directional change sensor for motor vehicles
IPC: G01P1/00
Filed: 1992-11-05
Abstract: A change-of-direction sensor for motor vehicles, particularly for an accident data recorder with coils arranged at right angles to one another and in each case having a core of amorphous ferromagnetic metal is proposed which is optimally designed for use in such a device, that is to say in accordance with large-scale production conditions and with the least possible power consumption. In a preferred embodiment it is proposed to arrange the coils (15, 16) on a circuit board (17) carrying the electronic components of the accident data recorder, to provide, for setting the operating point of the transmitters of the change-of-direction sensor, a permanent magnet (30) which is adjustably arranged diagonally to the coils (15/16) on the circuit board (17), and to use an emitter-coupled oscillator (1) for each transmitter. <IMAGE>
Patent IL-103677-A0 (IL)
Title: Expression vectors for gene therapy
IPC: C12N15/12
Filed: 1992-11-06
Abstract: Gene therapy involves the transfer and stable insertion of new genetic information into cells. The present invention is directed to safe vectors for gene therapy and thus provides hybrid parvovirus vectors which are capable of site-specific integration into a mammalian chromosome without substantial cytotoxicity, and which direct erythroid cell-specific expression of heterologous genes. The hybrid vector is useful in gene therapy, particularly in the treatment of hemoglobinopathies and other hematopoietic diseases. A method of delivery of constitutive levels of a pharmaceutical product and a method of producing a recombinant protein are also provided.
Patent IL-106936-A0 (IL)
Title: Substituted cyclohexane derivatives,processes for their preparation and the use of the compounds for treating diseases
IPC: C07C235/40
Filed: 1993-09-07
Abstract: Cyclohexane derivatives of the formula I <IMAGE> in which the radicals R<1> to R<6>, X, Y and Z have the meanings indicated, and a process for the preparation of these compounds are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
Patent IL-114674-A0 (IL)
Title: Aluminium oxide coated tool and a method of making the same
IPC: C23C30/00
Filed: 1995-07-19
Abstract: According to the present invention there is provided a tool at least partly coated with at least two refractory layers of which one of the said layers is a fine grained  alpha -Al2O3-layer which is the top layer along the cutting edge-line and the other a TiCxNyOz- or a ZrCxNy-layer being the top layer on the clearance face. The coated tool exhibits excellent flank and crater wear and high resistance to flaking, particularly when used for machining of low carbon steel and stainless steel. Used cutting edges can easily be identified by the naked eye. <MATH>
Patent IL-129363-A0 (IL)
Title: Carbohydrate purification using ultrafiltration reverse osmosis and nanofiltration
IPC: C13B30/08
Filed: 1997-10-09
Abstract: The invention provides methods for purifying carbohydrates, including oligosaccharides, nucleotide sugars, and related compounds, by use of ultrafiltration, nanofiltration and/or reverse osmosis. The carbohydrates are purified away from undesired contaminants such as compounds present in reaction mixtures following enzymatic synthesis or degradation of oligosaccharides.
Patent IL-130324-A0 (IL)
Title: Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators
IPC: A61K31/495
Filed: 1999-06-07
Abstract: Use of a compound of formula (I), wherein R<1 >is H or hydrocarbyl; R<2 >is a hydrophobic radical; R<3 >is 3-(C2-C6)acyl-4-hydroxyphenyl, 3-hydroxyimino (C2-C6)-alkyl-4-hydroxyphenyl, or COOZ, wherein Z is H, (C1-C6) alkyl, aryl, aryl or ar(C1-C6) alkyl; and n is 1-20; and of a compound of formula (II), wherein R<4 >is (C1-C6) alkyl, cyano (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl or -CH2NR<7>R<8>, wherein R<7 >and R<8>, the same or different, is each H or (C1-C6) alkyl, or together with the N atom form a saturated or unsaturated 5-7 membered ring optionally containing a further heteroatom selected from N, O or S, the further N atom being optionally substituted, and either R<5 >is H and R<6 >is (C2-C6) acyl or hydroxyimino (C2-C6) alkyl, or R<5 >and R<6 >together with the phenyl ring form a quinoline, a 1,2,3,4-tetrahydroquinoline or a perhydroquinoline ring, for the preparation of pharmaceutical compositions for the treatment of Parkinson's disease or stroke.
Patent IL-139155-A0 (IL)
Title: Suspension device for connecting an item of on-board equipment to the structure of a vehicle particularly a rotary wing aircraft
IPC: G02B27/64
Filed: 2000-10-19
Abstract: The infra-red sensor mounting for a combat helicopter has a controllable locking system (20) to selectively prevent relative movement of the sections (5,6) of the sensor mounting. The sections are formed as plates attached to the helicopter airframe and the sensor. The plates are connected by suspension torsion bars to allow damped relative movement between the plates when not locked. The lock can be formed by multiple releasable tongue and groove joints.
Patent IL-140013-A0 (IL)
Title: Expandable preformed structures for deployment in interior body regions
IPC: A61F2/958
Filed: 1999-06-01
Abstract: An expandable structure made from an elastomer material is preformed to a desired geometry by exposure to heat and pressure. The structure undergoes controlled expansion and further distention in cancellous bone, with controlled deformation and without stress failure.
Patent IL-150736-A0 (IL)
Title: Altered strain of the modified vaccinia virus ankara (mva)
IPC: A61K39/275
Filed: 2001-03-10
Abstract: The invention provides new strains of the Modified Vaccinia Virus Ankara (MVA) that have a strongly reduced virulence for most mammals, especially humans, but nevertheless grows in cells of a continuous cell line approved for the production of a therapeutic agent such as a vaccine. The invention also provides a method for producing said adapted MVA strains. The adapted MVA can be used e.g. for parenteral immunization, as a vector system, or in the active or inactivated from as an adjuvant or as a regulator of the unspecific components of the immune system.
Patent IL-178770-A0 (IL)
Title: Method for making a two-dimensional helical fibre web
IPC: D04H13/00
Filed: 2006-10-19
Abstract: A transverse fiber sheet is lapped by being guided in a substantially radial direction back and forth along a path between circumferentially outer and inner edges of the sheet, with the transverse sheet being reversed at each end of its path, the width of the transverse sheet being narrowed between the outer circumferential edge and the inner circumferential edge, the transverse sheet being held in place as it is lapped. Substantially mutually parallel yarns or tows are pulled to form a helical longitudinal sheet of density per unit area that decreases between its outer edge and its inner edge. The transverse sheet and the helical longitudinal sheet are superposed and advance continuously in flat rotation, and they are assembled together to form a helical sheet which is removed.
Patent IL-187716-A0 (IL)
Title: Astigmatic intraocular lens
Filed: 2007-11-28
Abstract: The intraocular lens has a toroidal refractive front face and a toroidal refractive rear face. The intraocular lens also has a toroidal refractive lens surface, whose intersection curve is aspherical on a primary meridian (1, 2). The intraocular lens has a toroidal refractive lens surface with two primary meridians running at an angle to one another that does not equal 90 degrees.
Patent IL-229550-A0 (IL)
Title: Use of edg receptor binding agents in cancer
IPC: A61K45/00
Filed: 2013-11-21
Abstract: Provided is a method for treating solid tumors, e.g tumor invasiveness, and particularly inhibiting or controlling deregulated angiogenesis, using a sphingosine-1-phosphate receptor agonist, optionally in combination with a chemotherapeutic agent. The invention also comprises a combination of a sphingosine-1-phosphate receptor agonist with a chemotherapeutic agent.
Patent RO-137281-A0 (RO)
Title: Carbon nanofibers decorated with nickel particles produced by electrospinning
Inventor: MARIN ELENA
IPC: C01B32/00
Filed: 2022-10-31
Abstract: The invention relates to porous carbon materials decorated with nickel nanoparticles produced by electrospinning and to a process for preparing them. The claimed carbon materials consist of carbon fibers originating from PAN precursor in a mass ratio of 90...97% and Ni in a mass ratio of 0.7...3.5%, the final product having a BET specific surface area ranging between 3 ...46 m2g-1 and a total pore volume between 0.005...0.08 cm3g-1. The claimed process consists in preparing a solution consisting of a polymeric precursor of C, namely polyacrylonitrile, and a Ni salt that can be Ni nitrate, Ni acetate or Ni acetylacetonate, after which, the Ni salt is introduced over the solution prepared by ultrasonic dissolution of PAN in DMF solvent at 70°C, while continuing the ultrasonic stirring for another 4 h and 30 min., the final solution being electrospun in a high voltage field, then carbonized in a single step in a tubular furnace at a temperature between 700...1400°C in an inert environment.
Patent MW-1287-A1 (MW)
Title: Waltermark security numbering
IPC: B41M3/10
Filed: 1987-02-17
Abstract: A document security system is provided by providing each document with a synthetic watermark, for instance using the process, compositions and apparatus disclosed in the aforementioned U.S. patent of Norris, et al and, within the perimeter of at least one of the symbols which is provided by the synthetic watermark, an identical complementary or otherwise corresponding symbol is printed using ink, paint, dye, stain or similarly contrastingly pigmented substance so as to create, in combination with the synthetic watermark a juxtaposition that can be looked-for as evidence that the document is genuine and its serial number unaltered.
Patent ZM-6475-A1 (ZM)
Title: Process for the production of ter-alkyl ethers
IPC: C07C41/06
Filed: 1975-05-21
Abstract: 1506312 Tertiary alkyl ethers SNAMPROGETTI SpA 13 May 1975 [21 May 1974] 20209/75 Heading C2C A tertiary alkyl ester is produced by reacting an alcohol with an olefin having a carboncarbon double bond on a tertiary carbon atom in the presence of an ion-exchange resin in atleast two stages, whereinin one stage the alcohol is present in excess and in another stage the olefin is in excess. The reaction may be carried out using two reactors; all of one reactant is fed to one reactor while all or part of the other reactant is fed to the other reactor, and reaction products are at least in part circulated from one reactor to the other. The invention is exemplified by the reaction of isobutene in a mixed olefin stream with methanol to form methyl tertiary butyl ether. A suitable apparatus is described. Reference has been directed by the Comptroller to Specification 1,176,620.
Patent ZW-9392-A1 (ZW)
Title: Oral presentation forms for acid-unstable active compounds
Inventor: DR RANGO DIETRICH
IPC: A61K31/44
Filed: 1992-06-15
Abstract: The invention relates to compositions for oral administration containing pantoprazole which consist of a core, of an intermediate layer and of an enteric outer layer.