Patent SG-11201811225R-A (SG)
Title: Ar+ breast cancer treatment methods
Inventor: HATTERSLEY GARY
IPC: C07D413/10
Filed: 2017-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/223115 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: Declarations under Rule 4.17: A61K 31/277 (2006.01) C07D 413/12 (2006.01) C07D 413/10 (2006.01) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) (21) International Application Number: — as to the applicant's entitlement to claim the priority of the PCT/US2017/038390 earlier application (Rule 4.17(iii)) (22) International Filing Date: Published: 20 June 2017 (20.06.2017) — with international search report (Art. 21(3)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/353,350 22 June 2016 (22.06.2016) US 62/377,497 19 August 2016 (19.08.2016) US 62/461,546 21 February 2017 (21.02.2017) US (71) Applicant: RADIUS HEALTH, INC. [US/US]; 950 Win- ter Street, Waltham, MA 02451 (US). _ (72) Inventors: HATTERSLEY, Gary; 14 Woodman Drive, Stow, MA 01775 (US). SAEH, Jamal; 950 Winter Street, Waltham, MA 02451 (US). YU, Ziyang; 950 Winter Street, — Waltham, MA 02451 (US). MILLER, Chris; 1685 Mill- burne Road, Lake Forest, IL 60045 (US). BIHANI, Teeru; = - 160 Cambridge Park Drive, Apt. 524, Cambridge, MA =_ 02140 (US). Agent: WANG, Yingli et al.; Perkins Coie LLP, P.O. Box (74) 1247, Seattle, WA 98111-1247 (US). Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — 1-1 in MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Il Il M ei ! (54) Title: AR+ BREAST CANCER TREATMENT METHODS IN ,-1 (57) : A method for treating AR+ breast cancer in a subject comprising administering to the subject an AR agonist (e.g., SARMs 0 such as RAD 140), or in combination with one or more therapeutic agents selected from the group consisting of cdk4/6 inhibitors, m- \" TOR inhibitors, PI3k inhibitors, PARP inhibitors, BCL-2 inhibitors, and MCL-1 inhibitors. C