baber/WOPTO huggingface dataset:
Patent BR-0308304-A (BR)
Title: Processo para preparar forma i cristalina de cabergolina
Inventor: SHEIKH AHMAD Y
IPC: A61P25/16
Filed: 2003-03-10
Abstract: "PROCESSO PARA PREPARAR FORMA I CRISTALINA DE CABERGOLINA". A presente invenção refere-se a um processo para produção de forma I cristalina de cabergolina, cujo processo compreende a preparação de forma V usando heptano como solvente de precipitação, e sua exclusiva conversão em forma I cristalina de cabergolina. O presente processo de cristalização do sistema solvente tolueno-heptano para forma V, envolve a 'adição reversa' de concentrado tolueno-cabergolina a heptano frio.
Patent BR-0309026-A (BR)
Title: Derivados de indolizina 1,2,3 substituìda, inibidores dos fgfs, o respectivo processo de preparação e as composições farmacêuticas que as contêm
Inventor: BADORC ALAIN
IPC: C07D455/02
Filed: 2003-04-02
Abstract: "DERIVADOS DE INDOLIZINA 1,2,3 SUBSTITUìDA, INIBIDORES DOS FGFS, O RESPECTIVO PROCESSO DE PREPARAçãO E AS COMPOSIçõES FARMACêUTICAS QUE AS CONTêM". A presente invenção refere-se a derivados de fórmula I: na qual R~ 1~ representa -OH, alcóxi(C~ 1~-C~ 5~), carboxila, alcoxicarbonila (C~ 2~-C~ 6~), NR~ 5~R~ 6~, -NH-SO~ 2~-Alk, -NH-SO~ 2~-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO~ 2~-Alk, -O-(CH~ 2~)~ n~-cAlk, -O-Alk-COOR~ 7~, -O-Alk-O-R~ 8~, -O-Alk-OH, -O-Alk-C(NH~ 2~):NOH, -O-Alk-NR~ 5~R~ 6~, -O-Alk-CN, -O-(CH~ 2~)~ n~-Ph, -O-Alk-CO-NR~ 5~R~ 6~, -CO-NH-(CH~ 2~)~ m~-COOR~ 7~, -CO-NH-Alk, R~ 2~ representa H, alquila (C~ 1~-C~ 5~), halogeneto de alquila (C~ 1~-C~ 5~), cicloalquila (C~ 3~-C~ 6~) ou fenila eventualmente substituída, A representa um radical -CO-, -SO- ou -SO~ 2~-, R~ 3~ e R~ 4~ idênticos ou diferentes representam, cada um, H, alcoxila (C~ 1~-C~ 5~), amino, carboxila, alcoxicarbonila (C~ 2~-C~ 6~), -OH, nitro, hidroxiamino, -Alk-COOR~ 7~, -NR~ 5~R~ 6~, -NH-Alk-COOR~ 7~, -NH-COO-Alk, -N(R~ 11~)-SO~ 2~-Alk-NR~ 9~R~ 10~, -N(R~ 11~)-SO~ 2~-Alk, -N(R~ 11~)-Alk-NR~ 5~R~ 6~, -N(R~ 11~)-CO-Alk-NR~ 9~R~ 10~, -N(R~ 11~)-CO-Alk, -N(R~ 11~)-CO-CF~ 3~, -NH-Alk-HetN, -O-Alk-NR~ 9~R~ 10~, -O-Alk-CO-NR~ 5~R~ 6~, -O-Alk-HetN, ou R~ 3~ e R~ 4~ formam juntos um heterociclo insaturado de 5 a 6 cadeias, eventualmente sob a forma de um de seus sais farmaceuticamente aceitáveis.
Patent BR-0311594-A (BR)
Title: ensaio de células humanas para determinar o efeito de compostos de amostra na expressão de intensificador de col2
Inventor: BUCKBINDER LEONARD
IPC: C12Q1/68
Filed: 2003-05-26
Abstract: "ENSAIO DE CéLULAS HUMANAS PARA DETERMINAR O EFEITO DE COMPOSTOS DE AMOSTRA NA EXPRESSãO DE INTENSIFICADOR DE COL2". A presente invenção refere-se à atividade (crescimento/diferenciação/produção de matriz extracelular) de condrócitos humanos e ao efeito do fator de transcrição Sox9 e do intensificador de Col2 como medida de tal atividade. Refere-se também a uma célula quimérica e a um ensaio utilizando tal célula útil na previsão do efeito de compostos de amostra na atividade de condrócitos medida através da expressão/atividade de Sox9 e Col2.
Patent BR-0313523-A (BR)
Inventor: WHITE MICHAEL J
IPC: C07J1/00
Filed: 2003-03-21
Abstract: The present invention provides 5-androsten-3beta-ol steroid intermediates and processes for their preparation.
Patent BR-0317983-A (BR)
Title: Processo aperfeiçoado para a preparação contìnua de (met)acrilatos de alquila com reciclagem repetida do catalisador
Inventor: HILTNER HORST
IPC: C07C67/03
Filed: 2003-11-21
Abstract: "PROCESSO APERFEIçOADO PARA A PREPARAçãO CONTìNUA DE (MET)ACRILATOS DE ALQUILA COM RECICLAGEM REPETIDA DO CATALISADOR". A presente invenção refere-se a um método aperfeiçoado para a produção contínua de (met)acrilatos de alquila através da transesterificação do (met)acrilato de metila com álcoois, que são pesados em comparação com metanol. Uma térmica de processamento especial torna-o possível para obter novos níveis de qualidade de produto. Também podem ser obtidos altos rendimentos espaço-tempo completos. A invenção é caracterizada pelo uso múltiplo de um catalisador homogêneo que através disso reduz, significativamente os custos de agentes auxiliares.
Patent BR-8204465-A (BR)
Inventor: KAUTZ JON FRANCIS
IPC: H01R43/00
Filed: 1982-07-29
Abstract: The disclosed invention is an improvement to a card edge connector insertion tool. More particularly, the improvement includes a spring loaded guide block mounted on the insertion tool which enables the tool to be machine drivable for semi-automatically mounting a connector onto a printed circuit board.
Patent BR-8301765-A (BR)
Inventor: SCHWEISS PETER
IPC: D21F1/70
Filed: 1983-04-04
Abstract: 1. Flotation apparatus having an injector serving to introduce a mixture of gas and fluid into the flotation apparatus, the injector having a constriction and a mixing section (5) behind this and also a gas intake guided centrally into the constriction, characterised by the following features of the injector : a) the constriction (3, 4) widens abruptly towards the mixing section (5), b) the centrally guided gas intake (6) ends a short distance behind the constriction (3, 4) in the mixing section (5), c) the mixing section (5) has a second constriction (7) widening like a diffusor.
Patent BR-8500961-A (BR)
Inventor: MAULDING DONALD ROY
IPC: C07D231/12
Filed: 1985-03-04
Abstract: This application relates to a process for the preparation of substituted and unsubstituted 1-alkyl-3,5- diphenylpyrazole compounds by reacting a 3,5-diphenyl (substituted or unsubstituted) pyrazole with an excess of dialkyl sulfate, in the presence of aqueous alkali hydroxide and a quaternary ammonium phase transfer catalyst.
Patent BR-8503125-A (BR)
Inventor: KUHFUSS RUNWALT
IPC: B41F11/02
Filed: 1985-06-28
Abstract: Processing is based on print carriers in the form of security paper webs or security paper sheets, containing security paper prints which are arranged in the manner of matrices in transverse rows and longitudinal rows and on which spoilt notes are identified by a mark which can be read by a reading instrument. The print carriers pass, in succession, by a reading instrument which detects the positions of the spoilt notes and feeds them into a computer for storage, a cancellation printer controlled by this computer, which provides spoilt notes with a cancellation print, and a numbering machine. The numbering mechanisms of this numbering machine are moved forward by the computer in such a way that always the satisfactory security paper prints, placed in succession in any longitudinal row, are serially numbered, the spoilt notes being neglected. Subsequently, the print carries, having passed by another reading instrument, are cut up into individual security papers, the spoilt notes are separated out in a separation device and the remaining, serially numbered individual security papers are assembled to form bundles, each having a complete numerical sequence. In this way, correct and complete numerical sequence of the security papers contained in the automatically produced security paper bundles and security paper parcels is ensured, in spite of the separation of spoilt notes.
Patent BR-8605978-A (BR)
Inventor: BERNER GODWIN
IPC: C08G63/685
Filed: 1986-12-05
Abstract: Light-stabilised polymer microparticles which contain at least one light screen are prepared by polymerising suitable monomers, with at least part of the polymerisation being carried out in the presence of at least one light screen. The polymer microparticles can be used in coating compositions which contain a disperse phase containing these particles and a liquid continuous phase. Coatings and paints based on the compositions according to the invention are distinguished by increased weathering resistance, in particular high light stability.
Patent BR-8606838-A (BR)
Inventor: ADELMAN HERBERT B
IPC: B29C65/20
Filed: 1986-08-20
Abstract: Heat sealing of wrapper laminates (31, 32) made of foam (102) supported by a porous substrate sheet is improved by coating on the foam-engaging face of the substrate a barrier layer such as polyvinylalcohol to keep the foam (102) when melted from bleeding through the substrate. The support for the foam can alternatively be non-porous film such as polyethylene terephthalate. In a cold sealing embodiment the foam face of supported foam wrappers has a cohesive-nonadhesive layer which can contain improved volatile corrosion inhibitor and/or antistat compositions that do not shorten its shelf life below about six months. One such composition is a mixture of dicyclohexylamine with 2-amino-2-lower-alkyl-propadiol-1,3. Protective colloid such as polyvinylpyrrolidone is preferably also added to improve the compatability of the volatile corrosion inhibiting composition with the rubber latex that provides the cohesive-nonadhesive characteristics. Heat sealing of wrapper can be effected with the help of hot melting shoes (39 and 41).
Patent BR-8707392-A (BR)
Inventor: THOMSEN ERIK DYHR
IPC: B42D1/00
Filed: 1987-07-17
Abstract: A picture book, whose left side may be provided with a story text, has at least at the right side a picture plane (in fig. 3 a representation of rails and a cat). According to the invention, the picture plane is provided with depressions to receive interconnectible toy elements (3-6). The picture plane and the associated depressions are so arranged that a child will be guided by the story text to place the interconnectible toy elements correctly in the picture plane to provide a three-dimensional representation of the situation described in the story text. The depressions may be so placed in the picture plane that the building elements are placed with a predetermined mutual modular distance, which makes it possible to build several layers with the interconnectible elements.
Patent BR-8804985-A (BR)
Inventor: CHILDRESS THOMAS EDGEWORTH
IPC: C07F7/04
Filed: 1988-09-27
Abstract: An extractive distillation process for recovering trimethoxysilane from a trimethoxysilane-methanol mixture is provided using as the extractive solvent tetramethoxysilane.
Patent BR-8901196-A (BR)
Inventor: GIMPERA JOSE
IPC: B22D41/08
Filed: 1989-03-16
Abstract: A gate valve for an outlet, in particular an extended outlet, of a vessel containing molten metal comprises an immovable, refractory gate-valve part (3) with inflow and outflow openings and a refractory gate-valve part (13) which can be moved sealingly relative to the immovable gate-valve part and has a connecting channel for connecting the inflow and outflow openings in the open position of the gate valve. In order to avoid penetration openings for the connecting channel, the movable gate-valve part (13) has as a connecting channel at least one recess (15) extending on the circumferential surface (14) of the movable gate-valve part (13). 
<IMAGE>
Patent BR-8901340-A (BR)
Inventor: MICHAUD PHILIPPE
IPC: C08G73/14
Filed: 1989-03-21
Abstract: New aromatic polyamideimides whose chains contain alkenyloxy end groups. 
<??>More precisely, these polymers correspond to the formula: 
<IMAGE>
 in which: D denotes a valency bond, an atom or a divalent group; B denotes a trivalent aromatic radical containing at least 6 carbon atoms; m is at least equal to 1; and X denotes the radical of formula: 
<IMAGE>
 in which R = H or CH3, R' = CH3 and n = 0, 1, 2 or 3. These polymers are obtained by direct reaction of an aromatic diisocyanate, of a tricarboxylic acid monoanhydride and of a carboxylic monoacid substituted by an alkenyloxy group. 
<??>These polyamideimides can be employed especially for the production of coating films and of moulded articles and they can be crosslinked using heat.
Patent BR-8902308-A (BR)
Inventor: PARKER ALAN
IPC: B67D1/04
Filed: 1989-05-17
Abstract: A dispenser for a gasified beverage comprising a housing (1), a container (5) of gasified beverage in said housing, a container (8) of gas in said housing for topping up the beverage container with gas, and a single dispensing valve unit (4) operatively connected to both of said containers and manually accessible to the user, said valve unit being so arranged, as, when operated, both to dispense the beverage and to cause topping up gas to be released from the gas container and supplied to the beverage container.
Patent BR-9007549-A (BR)
Inventor: RUCH WOLFGANG WALTER
IPC: C22C1/08
Filed: 1990-07-11
Abstract: Particle reinforced low cost metal foam is provided by a process of manufacturing metal foam based on foaming of molten composite material using finely dispersed cellulating gas.
Patent BR-9007980-A (BR)
Inventor: DECKWER WOLF-DIETER
IPC: C12M1/36
Filed: 1990-12-24
Abstract: The invention relates to a process for high cell density fermentation of Escherichia coli in an agitated boiler fermenter.
Patent BR-9100977-A (BR)
Inventor: MCBRIERTY VINCENT
IPC: G02C7/04
Filed: 1991-03-12
Abstract: The invention provides a process for curing a photopolymerisable contact lens material comprising the step of irradiating the photopolymerisable contact lens material with laser radiation having a wavelength of between approximately 200nm to approximately 400nm for a predetermined time period.
Patent BR-9200259-A (BR)
Inventor: DAMRAU WAYNE A
IPC: D21H25/10
Filed: 1992-01-27
Abstract: A method of and apparatus for applying coating liquid to a web of paper traveling over a web supporting surface at speeds of 3,000, 4,000 and more feet per minute to produce a coated web free of streaking and other imperfections comprises apparatus for and the sequential steps of distributing coating liquid in a turbulent state over the supported web through a limited application zone within a very short dwell time of the turbulent liquid on the web; subjecting the coating liquid on the supported web to an initial doctoring by means of a primary doctor blade biased under pressure against the coated web at the rear edge of the application zone to form on the web downstream from the zone a relatively quiescent layer of coating liquid having a wet film thickness sufficiently in excess of the final wet film thickness to accommodate a subsequent final wet film doctoring of the coating liquid on the web; and, at a location downstream and isolated from the application zone, subjecting the relatively quiescent layer of excess coating liquid on the supported web to a final doctoring by means of a final doctor blade biased under pressure against the coated web to remove the excess coating from the web and to level and smooth the coating retained on the web to final wet film thickness and smoothness. <IMAGE>
Patent BR-9206426-A (BR)
Inventor: JANSSON PATRICIA
IPC: H01F1/20
Filed: 1992-08-26
Abstract: PCT No. PCT/SE92/00587 Sec. 371 Date Mar. 22, 1994 Sec. 102(e) Date Mar. 22, 1994 PCT Filed Aug. 26, 1992 PCT Pub. No. WO93/03874 PCT Pub. Date Mar. 4, 1993.The invention relates to an iron-based powder composition which, in addition to a substantially non-alloyed Fe-powder, comprises Sn and P, optionally lubricant and at most 1.0% by weight of impurities. In the composition, Sn and P are present as an SnP-alloy in powder form, or else Sn is present in the form of a metallic powder and P is present in the form of a ferrophosphorous powder, the Sn-content, based on the total iron-based powder composition, being at least 4.5% by weight, and the individual particles, which contain Sn and P, being present as particles substantially separate from the particles in the non-alloyed Fe-powder. Finally, Sn and P may also be present as an SnP-alloy in powder form, and Sn may also be present as a metallic powder. This composition may optionally also contain P as a ferrophosphorous powder.
Patent BR-9305875-A (BR)
Inventor: ROECKRATH ULRIKE DR
IPC: B05D7/16
Filed: 1993-02-03
Abstract: PCT No. PCT/EP93/00242 Sec. 371 Date Aug. 23, 1994 Sec. 102(e) Date Aug. 23, 1994 PCT Filed Feb. 3, 1993 PCT Pub. No. WO93/15849 PCT Pub. Date Aug. 19, 1993.The invention relates to a process for the production of two-coat finishes of the basecoat/clearcoat type, in which nonaqueous transparent topcoats are employed, which comprise (A) a synthetic resin containing hydroxyl groups or a mixture of synthetic resins containing hydroxyl groups, (B) an amino resin or a mixture of amino resins, and (C) a blocked polyisocyanate or a mixture of blocked polyisocyanates, in which component (C) comprises isocyanate groups blocked both with a blocking agent (I) and with a blocking agent (II), and the blocking agent (I) being a dialkyl malonate, the blocking agent (II) being a blocking agent which is different from (I) and contains active methylene groups or an oxime, and the ratio of equivalents between the isocyanate groups blocked with (I) and the isocyanate groups blocked with (II) being between 1.0:1.0 and 9.0:1.0.
Patent BR-9305972-A (BR)
Inventor: BAKER SAMUEL
IPC: D03D15/00
Filed: 1993-02-25
Abstract: PCT No. PCT/CA93/00075 Sec. 371 Date Oct. 24, 1994 Sec. 102(e) Date Oct. 24, 1994 PCT Filed Feb. 25, 1993 PCT Pub. No. WO93/17180 PCT Pub. Date Sep. 2, 1993A paper machine dryer fabric includes hollow thermoplastic monofilaments to replace at least a portion of the wefts, also known as cross-machine direction strands. Fabrics including such monofilaments may be either a woven fabric, or a spiral fabric. The deformable nature of the hollow monofilaments decreaes the air permeability of the fabric, and in the case of spiral fabrics, improves monofilaments retention within the helical coils between the hinge yarns. The hollow monofilaments have a solidity in the range of from about 60% to about 75%. A suitable thermoplastic is polyethylene terephthalate. Hollow monofilaments do not have the disadvantages of other deformable yarns, such as spun yarns, multifilament yarns or plied monofilament yarns, each of which tend to hold and entrap within their structure both water and foreign matter.
Patent BR-9400407-A (BR)
Inventor: POAD WILLIAM J
IPC: B05B13/04
Filed: 1994-02-01
Abstract: A rodless air cylinder is mounted transversely of the conveyor. The sprayer is connected to the piston of the rodless cylinder so that the sprayer is moved transversely of the rows of containers. The rodless cylinder is supported for pivotal movement about a vertically axis so that the axis of the cylinder may be moved to a position other than a right angle to the longitudinal axis of movement of the conveyor. The offset of the angle from a right angle, and the speed of transverse of the piston, is coordinated with the conveyor speed.
Patent BR-9400645-A (BR)
Inventor: LEMAIRE JACQUES
IPC: B01F3/08
Filed: 1994-02-23
Abstract: The invention relates to the automatic injection of an additive into the fuel tank of a motor vehicle, from an on-board additive tank. According to the invention, the quantity of additive to be withdrawn from the additive tank (101) is calculated using an on-board computation unit (102), and the quantity of additive thus calculated is injected by pulsed spraying, this spraying being carried out directly into the liquid bulk of fuel. This pulsed spraying is preferably carried out by controlling a piston positive-displacement pump (112), with a number of piston strokes which is automatically determined as a function of the quantity of additive to be withdrawn.   <IMAGE>
Patent BR-9407546-A (BR)
Inventor: FURUMOTO HERBERT
IPC: D21G9/00
Filed: 1994-09-05
Abstract: PCT No. PCT/EP94/02954 Sec. 371 Date Mar. 19, 1996 Sec. 102(e) Date Mar. 19, 1996 PCT Filed Sep. 5, 1994 PCT Pub. No. WO95/08019 PCT Pub. Date Mar. 23, 1995Apparatus for the operation of a plant for producing deinked pulp with state analysers constructed in the form of neural networks for the waste paper suspension. At least one measuring device (ME) records spectral and/or physical characteristic values (IMf, Mp) of a waste paper suspension (PS). Furthermore, there are closed-loop or open-loop control devices (RS1 . . . RS8) for operating means of a waste paper preparation (AAA) in the plant. According to the invention, there is at least one state analyser (ZA), configured in the form of a neural network (NNg) or a plurality of parallel neural networks (NN1 . . . NN4), for the waste paper suspension (PS). This analyser forms from the characteristic values (IMf, Mp) controlled variables (ST: AB, AZ, FL, AA, AS, AT) for process control of the closed-loop or open-loop control devices (RS1 . . . RS8) of operating means at least of the waste paper preparation (AAA). As controlled variables, the ratio of white to coloured papers (AB), the ratio of illustrated-magazine paper to newsprint paper (AZ), the average fibre length (FL), the ash content (AA), the content of dirt (AS) and/or the content of adhesive contaminants (AT) in the waste paper suspension (PS) are suitable with preference.
Patent BR-9407833-A (BR)
Inventor: BURNS MICHAEL EUGENE
IPC: D06L4/40
Filed: 1994-10-13
Abstract: The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.
Patent BR-9504466-A (BR)
Inventor: BOLD GUIDO
IPC: C07D213/65
Filed: 1995-10-19
Abstract: Antiretroviral compounds (which are effective, for example, against HIV) of the formula I <CHEM>  in which R1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is unsubstituted or is substituted by halogen, phenyl, lower alkoxy or a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl or 4H-1-benzopyranyl which is unsubstituted or substituted by oxo, hydroxyl, amino, lower alkyl, lower-alkoxycarbonyl and/or phenyl-lower-alkoxycarbonyl; lower alkanoyl which is unsubstituted or is substituted by one of the said unsubstituted or substituted heterocyclic radicals; arylcarbonyl or heterocyclylcarbonyl which are substituted by heterocyclyl or heterocyclyl-lower-alkyl; phenyl-lower-alkanoyl which is substituted by hydroxyl and lower alkyl; or arylsulfonyl; or the residue of an amino acid which is defined in accordance with the description (and which may be acylated on the amino nitrogen by one of the abovementioned acyl radicals); R2 and R3 are in each case cyclohexyl, cyclohexenyl, phenyl, naphthyl or tetrahydronaphthyl which are unsubstituted or substituted by lower alkyl, phenyl, cyanophenyl, phenyl-lower-alkyl, halogen, halo-lower-alkyl, cyano, hydroxyl, lower alkoxy, phenyl-lower-alkoxyl, pyridyl-lower-alkoxy, lower-alkoxy-lower-alkoxy, lower-alkoxycarbonyl-lower-alkoxy, carboxyl-lower-alkoxy, hydroxyl-lower-alkoxy, carbamoyl-lower-alkoxy, cyano-lower-alkoxy, and phenyl-lower-alkanesulfonyl which is unsubstituted or substituted by halogen; R4 is lower alkyl, cyclohexyl or phenyl; and R5 is lower alkyl; and n is 1 or 2, or salts thereof, are novel.
Patent BR-9506309-A (BR)
Inventor: SAKAMOTO NORIYASU
IPC: A01N39/00
Filed: 1995-07-20
Abstract: The dihalopropene compounds of the general formula [I] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.
Patent BR-9506885-A (BR)
Inventor: WRIGHT CRAIG D
IPC: A61K39/39
Filed: 1995-01-11
Abstract: The present invention features an adjuvanted vaccine, and methods for preparing an adjuvanted vaccine, preferably for immunizing against influenza, where the adjuvant is a lipid vesicle, and preferably is a nonphospholipid, paucilamellar lipid vesicle. The antigen may be encapsulated in the central cavity of the adjuvant, or mixed in solution with the adjuvant. Moreover, the adjuvant may carry a secondary adjuvant to further improve the immune response.