Patent SG-11201903312V-A (SG)
Title: Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
Inventor: ORONSKY BRYAN
IPC: A61K31/04
Filed: 2017-10-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111H11 01011011111 0111111101111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/071741 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7C 317/48 (2006.01) A61K 31/10 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7C 317/50 (2006.01) A61K 31/397 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7C 317/04 (2006.01) A61K 31/4025 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7C 317/06 (2006.01) A61K 31/44 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7D 205/04 (2006.01) A61K 38/05 (2006.01) CO7D 207/10 (2006.01) A61K 45/06 (2006.01) Published: CO7D 211/38 (2006.01) A61P 25/16 (2006.01) — with international search report (Art. 21(3)) CO7D 295/06 (2006.01) A61P 35/00 (2006.01) — before the expiration of the time limit for amending the A61N 5/10 (2006.01) A61P 25/28 (2006.01) claims and to be republished in the event of receipt of A61K 31/04 (2006.01) A61P 29/00 (2006.01) amendments (Rule 48.2(h)) A61K 31/19 (2006.01) A61P 31/00 (2006.01) A61K 31/198 (2006.01) A61P 33/00 (2006.01) A61K 31/215 (2006.01) (21) International Application Number: PCT/US2017/056454 (22) International Filing Date: 13 October 2017 (13.10.2017) (25) Filing Language: English Publication Language: English (26) Priority Data: (30) 62/408,182 14 October 2016 (14.10.2016) US Applicant: EPICENTRIX, INC. [US/US]; 4445 Eastgate (71) Mall, Suite 200, San Diego, CA 92121 (US). Inventors: ORONSKY, Bryan, T.; 28540 Matadero Creek (72) = Lane, Los Altos Hillas, CA 94022 (US). SCICINSKI, Jan; 19546 Vineyark Lane, Saratoga, CA 95070 (US). Agent: DAVIS, Chad, E. et al.; Goodwin Procter LLP, 100 (74) Northern Avenue, Boston, MA 02210 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (81) Designated States (unless otherwise indicated, for every (84) - kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 71' IN 1-1 N (54) Title: SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS 0 FOR USE IN MEDICINE --.... ,_ 1 (57) : The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, 0 and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune N disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze- 0 tidin-l-y1)-2-oxoethyl)sulfmy1)-D-alanine and variants thereof.