Patent MX-2010013360-A (MX)
Title: Pharmaceutical composition based on matricaria recutita l.fam asteraceae, hydroquinone, fluocinolone acetonide and tretinoin for treating hyperchromic spots on the skin.
Inventor: GURROLA JESUS HECTOR GALINDO
IPC: A61P17/02
Filed: 2010-12-06
Abstract: The present invention describes a pharmaceutical composition, which consists of a natural extract of Matricaria recutita L. Asteraceae family with hydroquinone, tretinoin, and fluocinolone acetonide which may be used for fading or removing hyperchromic spots on the skin, post-inflammatory pigmentation, sun spots, senile lentigo, melanotic freckles, and for the melasma and chloasma maintenance treatment for whitening the dark colour of the skin. 1. The present invention describes a pharmaceutical composition, which consists of a natural extract of Matricaria recutita L. Asteraceae family, in amounts varying from 10% to 50%, magnesium and aluminium silicate in amounts of 2% to 5%, corboxymethylcellulose in amounts of 0.01% to 5%, benzyl alcohol pure NF in amounts of 0.01% to 1.0%, cetyl alcohol in amounts of 1.0% to 10%, stearyl alcohol in amounts of 1.0% to 10%, stearic acid in amount of 1.0% to 10%, methylparaben in amounts of 0.01% to 1.0%, propylparaben in amounts of 0.01% tom 1.0%, glycerine in amounts of 1.0% to 10%, tretinoin in amounts of 0.01% to 1.0%, fluocinolone acetonide in amounts of 0.001% to 0.01%, citric acid in amounts of 0.01% to 0.1%, hydroquinone in amounts of 1.0% to 10%, sodium metabisulfite in amounts of 0.1% to 1.0%, anionic polymer in amounts of 5.0% to 25.0%, sodium lauryl sulphate in amounts of 1.0% to 15.0% and purified water in amounts of 10.0% to 50.0%. The aforementioned pharmaceutical composition may be used for fading and removing hyperchromic spots on the skin, post-inflammatory pigmentation, sun spots, senile lentigo, melanotic freckles, and for the melasma and chloasma maintenance treatment for whitening the dark colour of the skin. 2. A second pharmaceutical composition is provided, which consists of a natural extract of Matricaria recutita L. Asteraceae family, in amounts varying from 20.0% to 50.0%, cetyl alcohol in amounts of 1.0% to 10%, stearyl alcohol in amounts of 1.0% to 10%, gum tragacanth in amounts of 0.1% to 5.0%, me thylparaben in amounts of 0.01% to 1.0%, propylparaben in amounts of 0.01% tom 1.0%, glycerine in amounts of 1.0% to 10%, tretinoin in amounts of 0.01% to 1.0%, fluocinolone acetonide in amounts of 0.001% to 0.01%, citric acid in amounts of 0.01% to 0.1%, hydroquinone in amounts of to 1.0% to 10%, sodium metabisulfite in amounts of 0.1% to 1.0%, sodium lauryl sulphate in amounts of 1.0% to 20.0% and purified water in amounts of 40.0% to 60.0%. The aforementioned pharmaceutical composition may be used for fading and removing hyperchromic spots on the skin, post-inflammatory pigmentation, sun spots, senile lentigo, melanotic freckles, and for the melasma and chloasma maintenance treatment for whitening the dark colour of the skin. 3. A second pharmaceutical composition is provided, which consists of a natural extract of Matricaria recutita L. Asteraceae family, in amounts varying from 20.0% to 50.0%, methylparaben in amounts of 0.01% to 1.0%, propylparaben in amounts of 0.01% tom 1.0%, tretinoin in amounts of 0.01% to 1.0%, fluocinolone acetonide in amounts of 0.001% to 0.01%, citric acid in amounts of 0.01% to 0.1%, hydroquinone in amounts of to 1.0% to 10%, sodium metabisulfite in amounts of 0.1% to 1.0%, rose water in amounts of 20.0% to 40.0% and purified water in amounts of 10.0% to 40.0%. The aforementioned pharmaceutical composition may be used for fading and removing hyperchromic spots on the skin, post-inflammatory pigmentation, sun spots, senile lentigo, melanotic freckles, and for the melasma and chloasma maintenance treatment for whitening the dark colour of the skin.