baber/WOPTO huggingface dataset:
Patent DO-P2006000150-A (DO)
Title: Modulares no esteroides de receptores de progesterona
Inventor: SCHWEDE WOLFGANG
Filed: 2006-06-26
Abstract: La presente invencion se refiere a moduladores no esteroides del receptor de progesterona de la formula general I, a su use para la preparacion de medicamentos, asi como a las composiciones farmaceuticas que contienen estos compuestos. Los compuestos segun la invencion son apropiados para la terapia y la prevencion de enfermedades ginecologicas tales como endometriosis, leiomiomas de utero, hemorragias disfuncionales y dismenorrea y para la terapia y la prevencion de tumores dependientes de hormonas y para el use para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.
Patent DO-P2015000108-A (DO)
Title: Compuestos de pirrolopirimidina como inhibidores de quinasas
Inventor: CHEN WEI
IPC: C07D487/04
Filed: 2015-05-12
Abstract: Compuestos que forman enlaces covalentes con la tirosina quinasa de Bruton (Btk). También se describen inhibidores irreversibles de Btk, inhibidores reversibles de Btk y composiciones farmacéuticas que incluyen los compuestos. Además se describen métodos para utilizar los inhibidores Btk, solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, incluido el linfoma, y enfermedades o condiciones inflamatorias.
Patent DO-P2018000011-A (DO)
Title: Sales y profármacos de 1-metil-d-triptófano
Inventor: SANJEEV KUMAR
IPC: A61K31/661
Filed: 2018-01-11
Abstract: En la presente se proporcionan compuestos de profármacos y sales de indoximod y composiciones farmacéuticas que comprenden las sales y los profármacos de indoximod, que producen mejor concentración y exposición en plasma a indoximod en comparación con la administración directa de indoximod, en pacientes que necesitan tratamiento de inmunosupresión mediada por la vía indolamina-2,3-dioxigenasa, tales como pacientes con cáncer o enfermedades infecciosas crónicas.
Patent DO-P2021000195-A (DO)
Title: Compuestos de carbamoyl piridona tricíclicos con puente y su uso farmacéutico
Inventor: HYUNG-JUNG PYUN
IPC: C07D491/06
Filed: 2021-09-21
Abstract: Se describen compuestos para usar en el tratamiento o prevención de la infección por el virus de la inmunodeficiencia humana (VIH). Los compuestos tienen la siguiente fórmula (I):   I incluyendo estereoisómeros y sales farmacéuticamente aceptables del mismo, en la que R1, R2, L, W1, W2, X, Y y Z son como se define en el presente documento. También se describen métodos asociados con la preparación y uso de tales compuestos, así como composiciones farmacéuticas que comprenden tales compuestos.
Patent EC-SP12011642-A (EC)
Title: Fundas de plástico con propiedades insecticidas a base de una tiadiazinona o a base de una composición sinérgica insecticida que contiene un compuesto tiadiazinona y un compuesto de piretroide
Inventor: DAWSON CHARLES WILLIAM
IPC: A01N25/34
Filed: 2012-01-31
Abstract: La presente invención se refiere a una funda de plástico derivada de un concentrado de ingrediente activo de insecticida en resina de plástico; que se puede realizar con una composición sinérgica insecticida que contiene un compuesto de tiadiazinona (como el buprofezin) concentrado hasta en un 2% (p/p) y un compuesto de piretroide (como la bifentrina) concentrado en un 0.1% (p/p); o que se puede realizar con un solo compuesto de tiadiazinona (como el buprofezin) concentrado hasta en un 2% (p/p). La funda resultante se aplica en la zona afectada de la planta, en los racimos de recién emergidos o con una bráctea abierta para ejercer la barrera química contra las plagas insectiles del banano y el plátano.
Patent EC-SP12011835-A (EC)
Title: Moléculas de unión biespecíficas para la terapia anti-angiogénesis.
Inventor: BORGES ERIC
IPC: C07K16/28
Filed: 2012-04-26
Abstract: Moléculas de unión biespecíficas, en particular dominios variables sencillos de inmunoglobulina tales como VHH y anticuerpos de dominio, que comprenden un componente de unión a VEGF y un componente de unión a DII4 en una molécula. Composiciones farmacéuticas que contienen los mismos y su uso en el tratamiento de enfermedades que están asociadas con efectos mediados por VEGF y DII4 sobre la angiogénesis. Ácidos nucleicos que codifican las moléculas de unión biespecíficas, células hospedadoras y métodos para prepararlas.
Patent EE-200100663-A (EE)
Inventor: BONGRANI STEFANO
IPC: A61K45/00
Filed: 2000-06-07
Abstract: The invention relates to a method of treatment of left ventricular dysfunction, by administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof.
Patent GB-189706060-A (GB)
Title: Improvements in and relating to Sliding Sash Windows.
Inventor: RIDER ARCHIBALD GRIFFIN
Filed: 1897-03-08
Granted: 1898-02-26
Abstract: 6060. Rider, A. G., and Russel, E. March 8. Windows.-Relates to sashes arranged to fit one over the other in the same plane, when closed, as described in Specification No. 11,328, A.U. 1895. The inside linings or portions a, a<1> of the box frame are hinged to turn inwards to allow the sashes to swing inwards, and are secured in place by thumb-screws. The sash cord at each side of the frame is attached at one end to an angle-iron or projecting plate f at the lower corner of the bottom sash, passes over a pulley at the windowhead, below a pulley carried by a balance weight, over another pulley in the pulley stile, and is fixed to the centre of the upper sash stile by a metal plate. An angle-iron parting-bead h. let into the pulley stile, extends half way up the frame.
Patent GB-189712054-A (GB)
Title: Improvements in Linoleum or Linoleum-like Compositions.
Inventor: KNOCHE LOUIS
Filed: 1897-05-15
Granted: 1898-03-26
Abstract: 12,054. Knoche, L. May 15. Coated fabrics.-Ground cork is mixed with the oil of Elaeococca vernicia and heated for about two hours to 250‹ C. The mixture can then be spread on canvas or can be moulded or otherwise utilized. Resin, collodion, caster oil, &c. can be added to the mixture.
Patent GB-189713221-A (GB)
Title: Improvements in Electrical Cut-outs.
Inventor: DORMAN CHARLES MARK
Filed: 1897-05-28
Granted: 1897-07-03
Abstract: 13,221. Dorman, C. M., and Smith, R. A. May 28. Drawings to Specification. Cut-outs fitted with fuse wires are enclosed in a casing, and openings or vents are formed in the casing in close proximity to the wire, so that when it fuses the rush of gas tends to prevent the formation of an are, or to blow it out if formed. This system may be applied to cut-outs having baffle-plates or bridges, and to single and double pole cut-outs.
Patent GB-189726023-A (GB)
Title: Improvements relating to Electro-Magnetic Switch Apparatus for Railway Signalling and other Purposes.
Inventor: ALLISON CHARLES ARTHUR
Filed: 1897-11-09
Granted: 1898-01-22
Abstract: 26,023. Allison, C. A., [Banks, W. C.]. Nov. 9. Signalling and communicating between trains.- Relates to apparatus for switching into a circuit a second resistance should the first be shortcircuited. Fig. 1 shows the application to railway signalling. R, R<1> are the rails, G the usual signalling-relay, and B the battery. An electromagnetic switching-device is placed between one terminal of the battery and the rail, to switch in a resistance when the relay G is short-circuited, as by a train standing on the rails. Two electromagnet coils C<4>, C<5>, the former of high resistance and the latter of low, are arranged in the circuit, C' being normally short-circuited by the wire w<2> and spring s<3>. With a normal current, the armature A is not attracted, but when the relay G is shortcircuited the armature is attracted, the point a striking the spring and breaking the short-circuit at P<2>. In the preferred form of construction shown in Fig. 5, the core is double, and each leg is wound with two coils, one of high resistance and one of low, the former being normally shortcircuited by the spring contacts s, s'. The armature A carries an insulating-finger w, which, when the armature is attracted, is forced between the springs, so breaking the short-circuit.
Patent GB-189730544-A (GB)
Title: Improvements relating to the Electric Welding of Tubes and to Apparatus therefor.
Inventor: PARPART OTTO
Filed: 1897-12-24
Granted: 1898-10-29
Abstract: 30,544. Parpart, O. Dec. 24. Working by electricity; welding.-Relates to apparatus for welding longitudinal joints of tubes such as bicycle tubes. The poles of a transformer are connected with the standards D, D<1> which are insulated from the frame of the machine and carry supports for the copper discs E<1> which revolve in contact with the tube on opposite sides of the joint. The inclination of the discs E<1> can be adjusted as well as their position. A little in front of the discs E<1> are placed the pressure rolls F which complete the welding. They are insulated from the standards D, D' and are driven by suitable gearing. Fore and aft of the welding-apparatus are situated pairs of draught rolls which feed the tubes forward. A guide is placed before the first pair of feed-rolls, and a second guide between them and the welding- apparatus to ensure the joint of the tube being upwards. Additional rolls on the delivery side of the machine keep the tube straight. For welding taper tubes, special rolls of snail-cam section are employed.
Patent GB-189810267-A (GB)
Title: Improvements in Mechanism for Holding Type Matrix Blank and Setting Type Moulds for Casting from the Matrices.
Inventor: LOCK WILLIAM HENRY
Filed: 1898-05-05
Granted: 1899-05-05
Abstract: 10,267. Lock, W. H., and Pashley, C. W. May 5. Type.-Relates to mechanism for holding type matrix blanks in an engraving-machine, such, for example, as that described in Specification No. 11,938, A.D. 1895, and also to means for adjusting the moulds for casting types from the matrices. The type-casting mould shown in plan in Fig. 5 is formed with a cavity 33 for the body of the type, the sides 34 of the cavity being of variable distance apart. The matrix is held across the end of the cavity between the jaws 35. The width of a matrix is greater than the face of the type to be cast, the excess being a constant quantity in matrices of the same fount. For each fount a gauge shown in Fig. 7 is prepared. The diameter 36 is inserted in the mould opening 33 and the sides 34 adjusted to it, while the jaws 35 are fitted to a larger diameter 37. The jaws 35 and sides 34 are now clamped together so that, when the former are traversed, the latter move with them. Any type of the fount can now be cast, the matrix being clamped between the jaws 35.
Patent GB-189811130-A (GB)
Title: Improvements in and relating to Driving Mechanism for Bicycles.
Inventor: ALEXANDER THOMAS RUTLEDGE
Filed: 1898-05-16
Granted: 1898-07-30
Abstract: 11,130. Alexander, T. R., and Griffin- Beale, C. May 16. Driving-mechanism; frames.-The frame members A and B of a bicycle are forked at a and b, and chain-wheels D are mounted upon axles supported in each of the junction brackets of these forks on either side of the rear wheel. The motion is transmitted from the chain-wheels D to pinions E secured to the rear hub by chain gearing J. Chain stays F and a back fork G are also provided. If desired, the members A and B may be made double throughout.
Patent GB-189812867-A (GB)
Title: A Process for the Manufacture of Fabrics from Nitrated Yarns, chiefly Designed for Filtering Purposes.
Inventor: MULLER EMIL
Filed: 1898-06-08
Granted: 1898-07-09
Abstract: 12,867. M³ller, E. June 8. Filtering-media.-An improved fabric, which is especially suitable for filtering acid liquids, is made from cotton yarns which are nitrated in a mixture of nitric and sulphuric acids suitable for obtaining the required degree of nitrification, and which, after ample washing, are woven in a wet condition.
Patent GB-189818114-A (GB)
Title: Improvements in Packaging Machines.
Inventor: SMYSER HENRY EYSTER
Filed: 1898-08-23
Granted: 1898-10-22
Abstract: 18,114. Smyser, H. E. Aug. 23. Packeting.-Relates to means of carrying off the filled packets from the machine described in Specification No. 16,739, A.D. 1896, and holding their ends until the paste sets. The packets a<3> are filled, closed, and seated in packets N in a revolving horizontal wheel P, and after closing they come between plungers X, Y, which carry them down opposite recesses 333 in a lower wheel, into which they are thrust by a plunger Z carried on a rod 291, which also carries a plunger 340 for thrusting them out of the recesses at the opposite side of the machine. The lower wheel may be fixed to the upper wheel P as shown, or it may move independently of it ; the partitions 334 may be dispensed with, the packets being held simply between the top and bottom plates 331, 332. The top plate may be stationary, and the packets slid along beneath it. Or the plates 331, 332 may be formed on the links of a chain. A spring plate 350, Fig. 15, may be employed for packets of varying length.
Patent GB-189819785-A (GB)
Title: Improvements in Incandescent Bodies for Incandescent Electric Lamps and in the Process of Manufacturing the same.
Inventor: KELLNER CARL
Filed: 1898-09-17
Granted: 1899-05-06
Abstract: 19,785. Kellner, C. Sept. 17. Incandescent lamps. - Resistant incandescing bodies are moulded under great pressure from powdered very infusible metals, such as thorium, titanium, chromium, or wolfram, or alloys of such metals, or titanium nitride, and are oxidized on their surfaces by making them incandescent in air, or by immersing them in an oxidizing-liquid, or by making them anodes in a suitable electrolyte. Or the incandescing bodies may be moulded from mixtures of refractory oxides such as thoria, which may contain ceria, with very infusible metals or alloys, or with not more than 5 per cent. of graphite such as offers the greatest resistance to attack by a mixture of nitric acid and potassium chlorate. The graphite may be formed by adding cellulose soaked in zinc chloride to a mixture of refractory oxides, heating the body in a vacuum or a neutral gas such as nitrogen, and applying a high potential difference. Leading-in wires are moulded into thick ends formed on the incandescent bodies, or are fused therein by means of an arc.
Patent GB-189821212-A (GB)
Title: Improved Automatic Cycle Tyre Inflating Pump.
Inventor: LOEBINGER WILHELM
Filed: 1898-10-08
Granted: 1898-11-19
Abstract: 21,212. Loebinger, 'W. Oct. 8. Wheels wit h air-compressing appliances.-Means for inflating a pneumatic tyre by the motion of the vehicle, and for automatically putting out of action when the desired pressure is obtained, are shown in plan in Fig. 3. To the hub a is secured, by clips b, the pump cylinder c, the piston d of which is continuously pressed outward by the spring e. The pin i on the piston is connected to one end of the lever g, which is pivoted upon an extension f of the pump cylinder, and the other end of the lever has a roller k which, at each revolution of the wheel, runs upon the curved plate l connected with the fork, and so operates the piston. The plate l has a projecting sleeve n, which slides in a second sleeve o fixed to the fork, and the relative position of the two sleeves is controlled by a spring p, the tension of which is adjusted by means of the set-screw p<1>. When the pressure in the tyre is sufficiently high, the roller k in passing over the plate l depresses it until the catch r drops into the notch q, and so puts the pump out of action.
Patent GB-189824956-A (GB)
Title: Anti-vibrator for Incandescent Gas Lamps.
Inventor: SMITH ROBERT HENRY
Filed: 1898-11-26
Granted: 1899-05-13
Abstract: 24,956. Smith, R. H. Nov. 26. Incandescent gas lamps; anti-vibration devices; lighting gas.- The block P, Fig. 1, into which the burner p is screwed, is carried by two cones C, C which are connected with the block B on the tap T by flexible non-elastic sheets S, S impervious to gas and unaffected by temperature. These sheets may be flat or cone-shaped, and are preferably constructed of asbestos sheet ; they are secured by rings r, r and R, R. The gas for the pilot jet t passes up the bye-pass, between the sheets and the cones, and so to the bore in the block P. When a bye-pass is not required, one cone and one sheet are sufficient. In a modified form, one cone and two sheets are used, and the bye-pass is formed by a small metal tube soldered on the outside of the cone or by drilling holes along an internal rib. Fig. 3 shows a form in which one sheet S only is used ; the cone C is inverted and fixed to the tap T. The bye-passes in the cone C and block P are connected by a flexible tube t.
Patent GB-189901975-A (GB)
Title: Improvements in Means for Displaying Advertisements.
Inventor: TURNER EDWARD LADMORE
Filed: 1899-01-28
Granted: 1899-12-02
Abstract: 1975. Turner, E. L. Jan. 28. Advertising.-Tablets C bearing advertisements are pivoted or hinged to a vertical spindle D within a casing A having a transparent front, and are rotated intermittently on the spindle to change the exposed advertisements by means of a pawl S on an arm Q mounted on a spindle J having a mutilated pinion in gear with a mutilated driving- wheel. When the pinion J has made a half revolution, it is returned by a spring, the pawl S riding over the next frame and engaging with it.
Patent GB-189904722-A (GB)
Title: Improvements in Appliances for Teaching Children to Walk, Applicable also as Invalid Carriages.
Inventor: REINLI EDUARD
Filed: 1899-03-03
Granted: 1899-05-06
Abstract: 4722. Reinli, E. March 3. Invalid carriages.-A wheeled chair is provided with treadles r, r, which at one end are secured to crank-pins p and at the other to a centrally-pivoted lever s. As the chair is propelled, the movement of the treadles is an imitation of the operation of walking. The adjustable seat m and back n are arranged in such a way as to vary the amount of support they give to the inmate of the chair.
Patent GB-189905032-A (GB)
Title: Improvements in or relating to Steam Generators.
Inventor: BOULT ALFRED JULIUS
Filed: 1899-03-07
Granted: 1900-03-07
Abstract: 5032. Boult, A. J., [Rosier, C. A.]. March 7. Drawings to Specification. Steam-generator furnaces.-Relates to instantaneous water-tube boilers with tubes in concentric pairs. The products of combustion pass through the inner tubes, and play on the exterior of the outer tubes. An adjustable grid plate below the furnace grate regulates the supply of air. The Provisional Specification mentions the use of heavy oils as fuel.
Patent GB-189908562-A (GB)
Title: Improvements in Automatic Devices for Starting and Stopping Machinery, and performing like Operations, such as Blowing Whistles.
Inventor: COTTINGHAM EDWIN TURNER
Filed: 1899-04-24
Granted: 1899-07-22
Abstract: 8562. Cottingham, E. T. April 24. Starting and stopping.-Relates to apparatus for starting and stopping machinery and performing like operations, such as blowing whistles. Mounted on the plug b of a water tap is a lever, one arm a of which carries a weight g, while the other arm is hollow and carries a vessel h provided with an outlet valve i. Another arm c is connected to the spindle of the steam valve f which is to be controlled. The apparatus is locked in the position shown by an electromagnet k, l and catch lever m. When the magnet is energized, the lever is released, assumes the position shown in dotted lines,and opens the valve f. It remains thus until, owing to the passage of water into the vessel through the plug b and lever arm, the weight g is counterbalanced, when it returns to the normal position.
Patent GB-189911136-A (GB)
Title: Improvements in Mechanical Toys.
Inventor: LUETTICKE GEORGE FREDERICK
Filed: 1899-05-29
Granted: 1899-08-19
Abstract: 11,136. L³tticke, G. F. May 29. Mechanical toys.-Relates to wrestling and like figures cut out of sheet metal and pin-jointed together. The figures are pivoted at b, b<1> to a plate A, and may be actuated by rods d, d<1> and a spring a. Pin joints are placed at m, m<1>, n, n<1>, i, i<1>, x, x<1>, and unnatural positions of the figures are prevented by stops o, o<1> and pins r, r<1>, u, u<1>, v, v<1> running in slots as shown. Ordinary pin joints may be placed at v, v<1>.
Patent GB-189911325-A (GB)
Title: Improvements in or relating to Electric Traction.
Inventor: BOCHET ADRIEN
Filed: 1899-05-31
Granted: 1900-03-24
Abstract: 11,325. Bochet, A. May 31.. Electric railways and tramways with overhead conductors. Collectors; conductors. - Relates to electric traction of cars running on rails, and especially to the system in which the current is conveyed underground from the central station into overhead contacts arranged at intervals along the line in such a manner as to keep each car, or train of cars, in permanent communication with the source of electricity. The invention mainly consists of means for allowing for the vertical movement of the car on its springs, and of means for enabling this system to be used with trains of cars. (1) As shown in end elevation in Fig. 2, and enlarged side elevation in Fig. 3, a flexible conductor a extending the length of the car is supported on suitablymounted springs b at such a height that its resilience keeps it always touching one or another of the roller contacts d carried by standards h and connected with the conductor in the conduit j. (2) In the case of trains of cars, in one form, the several standards are each furnished with double brackets carrying two contacts at a distance from each other slightly in excess of that between the cars. In another form, the collector is made continuous throughout the train, but is mounted so as to permit of running round curves without subjecting it to strain. Fig. 7 shows this arrangement in plan. The conductors a are flexible, and are carried by springs as before, but the springs are attached to a cross-piece P and bars W suitably pivoted to the cars.
Patent GB-189912863-A (GB)
Title: Improvements in Perforating Machines, particularly Designed for Perforating Music Sheets for Automatic Musical Instruments.
Filed: 1899-06-20
Granted: 1899-08-19
Abstract: 12,863. Lake, H. H., [Aeolian Co.]. June 20. Automatic instruments; music recorders. - The invention relates to a machine for punching paper, more particularly applicable for preparing and reproducing tunesheets for musical instruments. A beam 13, reaching across the apparatus, and carrying loosely a number of punches 16, which are, however, prevented from falling out by pins 16', is rapidly reciprocated vertically by eccentrics 10. The eccentrics are carried by a shaft 9, which is driven by an electric or other motor. Besides operating the beam, the eccentrics also actuate a pawl and ratchet mechanism 35, for feeding a paper or like strip from a roller 33 to a take-up roller 36. The strip, shown at 29, Fig. 3, passes between a punching-block 26 and a stripper 28. The punches are selected by slides 17 which are notched at 17', and are drawn out by a mechanical or electro-magnetic device connected with the keys of a piano or other like instrument. When a key is depressed, the corresponding slide is drawn out, so that its solid part encounters one of the punches, which is thus kept in position for making a hole, it may be for several oscillations of the beam 13. The machine can also be used for copying tune sheets already made. The tune-sheet is passed over a table 42 between rollers 39 and 40, and is fed by a pawl and ratchet device operated by the eccentrics 10. Fingers 44 drop through the openings in the tune sheet, and complete electric circuits which energize the magnets 22 used for operating the slides 17. The details of the device may be modified.