Patent SG-11201408330X-A (SG)
Title: Compositions and methods related to prevention and treatment of rabies infection
Inventor: SHEN ENYUN
IPC: C12N15/13
Filed: 2012-05-24
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/174003 A1 (51) International Patent Classification: C07K16/10 (2006.01) A61K39/42 (2006.01) C12N15/13 (2006.01) A61P 31/14 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/CN2012/076012 24 May 2012 (24.05.2012) English (25) Filing Language: (26) Publication Language: English (71) Applicant (for all designated States except US): MOUNT- GATE GROUP LIMITED [GB/GB]; P.O. Box 957 Off­ shore Incorporations Centre Road Town, Tortola (VG). (72) Inventors; and (75) Inventors/Applicants (for US only): SHEN, Enyun [CN/CN]; Tower 15, No. 26 Xihuan South Road, Beijing Economic-Technological Development Area, Beijing 100176 (CN). REN, Shiqi [CN/CN]; Tower 15, No. 26 Xihuan South Road, Beijing Economic-Technological De­ velopment Area, Beijing 100176 (CN). (74) Agent: TDIP & PARTNERS; Room 2002 A-Building, North Ring Center, No. 18 Yumin Road, Xicheng District, Beijing 100029 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: COMPOSITIONS AND METHODS RELATED TO PREVENTION AND TREATMENT OF RABIES INFECTION FIG. 1 30000-1 20000- 3 —I 0£ 10000- m o o •t i> 3D11E3 3H10D3 5A1C10 6F11C1 -O- 7G11A3 0.64 3.2 16 80 400 200010000 Concentration of RVNA (ng/mL) i-H (57) Abstract: The present disclosure relates generally to anti-rabies antibodies that can bind and neutralize rabies virus. Antibod to - ® ies of the present technology are useful alone or in combination with therapies known in the art for the treatment or prevention of ra - CJ o & bies infection.