Patent SG-11201901658P-A (SG)
Title: Beta-lactamase inhibitor compounds
Inventor: COMITA-PREVOIR JANELLE
IPC: C07D471/08
Filed: 2017-09-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 March 2018 (22.03.2018) WIP0 I PCT omit VIII °nolo III 011110110111 °num oimIE (10) International Publication Number WO 2018/053215 Al (51) International Patent Classification: C07D 471/08 (2006.01) A61K 31/439 (2006.01) CO7D 211/78 (2006.01) A61P 31/04 (2006.01) (21) International Application Number: PCT/US2017/051692 (22) International Filing Date: 15 September 2017 (15.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/395,464 16 September 2016 (16.09.2016) US 62/456,423 08 February 2017 (08.02.2017) US (71) Applicant: ENTASIS THERAPEUTICS LIMITED [GB/GB]; Two Kingdom Street, London W2 6BD (GB). (72) Inventors; and (71) Applicants: BASARAB, Gregory, S. [US/US]; Enta- sis Therapeutics Limited, 35 Gatehouse Drive, Waltham, MA 02451 (US). MOSS, Bill [GB/GB]; Woodlands Wil- lowmead Drive, Prestbury, Cheshire SK10 4BU (GB). (72) Inventors: COMITA-PREVOIR, Janelle; 11 Prospect Street, Northborough, MA 01532 (US). DU- RAND-REVILLE, Thomas, Francois; 34 Birch Hill Road, Belmont, MA 02478 (US). GAUTHIER, Lise; En- tasis Therapeutics Limited, 35 Gateshouse Drive, Waltham, MA 02451 (US). O'DONNELL, John; 7 Beacon Street, Mattapoisett, MA 02739 (US). ROMERO, Jan; 8 Lang- ley Road, Arlington, MA 02474 (US). TOMMASI, Ruben; 16 Salamander Lane, Stow, MA 01775 (US). VERHEI- JEN, Jeroen, Cunera; 5 Stratton Drive, Westborough, MA 01581 (US). WU, Frank; 5 Aspen Way, Shrewsbury, MA 01545 (US). WU, Xiaoyun; 3 Hundreds Road, Westbor- ough, MA 01581 (US). ZHANG, Jing; 11 Run Brook Cir- cle, Subdruy, MA 01776 (US). (74) Agent: DAVIS, Steven, G. et al.; Mccarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: BETA-LACTAMASE INHIBITOR COMPOUNDS (57) : The present invention is directed to compounds which are be- ta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta- lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes com- pounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R 1 , R , R 2 3 , R 4 , R s and R 6 are described herein. R 2 R 3