baber/WOPTO huggingface dataset:
Patent JP-2008139914-A (JP)
Title: Radio communication terminal equipment
Inventor: MIURA HIROAKI
IPC: G06F9/48
Filed: 2006-11-29
Abstract: <P>PROBLEM TO BE SOLVED: To improve the distribution success rate by preventing the competition between application programs.  <P>SOLUTION: A radio communication terminal equipment is provided with a communication part 11; an operation part 17; and a control part for executing a first application program for receiving data by the communication part 11 and a second application program whose processing priority is higher than that of the first application program. When receiving the reception request of data based on the first application program by the communication part 11 in such a state that the second application program is started, the control part stops the execution of the second application program when any operation to the second application program by the operation part 17 has not been generated in a predetermined time or longer, and receives the data based on the reception request by starting the first application program.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008140838-A (JP)
Title: Inductor component and electronic apparatus using the same
Inventor: NAKAJIMA KOJI
IPC: H01F17/04
Filed: 2006-11-30
Abstract: <P>PROBLEM TO BE SOLVED: To suppress the occurrence of beats in an inductor component having a bobbin.  <P>SOLUTION: The component includes: a core 7 having a back leg 7D and legs 7A, 7B (7C) nearly vertically provided in the back leg 7D; a core 8 connected to the legs 7A, 7B (7C) magnetically; and the bobbin 10 inserted into the leg 7A. On a surface opposite to the core 8 in the leg 7A, an adhesive 9A is applied while projecting from the surface opposite to the core 8. The adhesive 9A sticks the leg 7A to the bobbin 10. Between the leg 7B (7C) and the core 8, a gap spacer 14, which has permeability lower than that of the core 7, is interposed.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008137782-A (JP)
Title: Foreign matter detecting device for passenger conveyor device
Inventor: YAMAGAMI TAKESHI
IPC: B66B29/06
Filed: 2006-12-04
Abstract: <P>PROBLEM TO BE SOLVED: To provide a foreign matter detecting device composed of a simple structure that detects foreign matter intruding from between a conveyor belt and a floor board member with high sensitivity at a terminal end of a conveyor device for loading a passenger on the conveyor belt and transferring the passenger.  <P>SOLUTION: The detecting device detects foreign matter wound in a terminal end drum 16 in the conveyor device wherein the conveyor belt 17 is endlessly wound around a starting end drum and the terminal end drum 16 and the passenger on the conveyor belt is transferred from the side of the starting end drum toward the side of the terminal end drum 16. The detecting device is composed of a switch bracket 26 provided in parallel to the width direction of the terminal end drum 16, and a contact-type switch 27 fixed to the switch bracket 26 and having the same length as the width of the terminal end drum 16.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008147814-A (JP)
Title: Digital broadcast receiving device and operating method thereof, and computer program
Inventor: SAWADA TAKASHI
IPC: H04N7/173
Filed: 2006-12-07
Abstract: <P>PROBLEM TO BE SOLVED: To provide a digital broadcast receiving device capable of reducing display of a blank picture with small hardware resources.  <P>SOLUTION: The digital broadcast receiving device 90 includes a tuner unit 100 and a decoder 104, a tuner unit 102 and a decoder 106, a switching circuit 114 which selects one of outputs of the decoders 104 and 106, an infrared photodetection unit 108 which generates a channel sending instruction, and a CPU 110 which controls the switching circuit 114 so as to select the output of a decoder decoding a signal of a specified channel in response to the channel sending instruction and simultaneously performing processing for controlling the tuners and decoders so that the other decoder may preread, receive, and decode a signal of a receivable channel candidate.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008147276-A (JP)
Title: Probe card and device and method for inspecting semiconductor wafer
Inventor: UKEDA TAKAAKI
IPC: G01R31/28
Filed: 2006-12-07
Abstract: <P>PROBLEM TO BE SOLVED: To set a fixed quantity of an overdrive at each measuring point in a semiconductor wafer at all times, and to realize a stable contact between a probe and a pad for inspection.  <P>SOLUTION: A probe card is used when inspecting the semiconductor wafer. The probe card concretely has a card body 101 arranging a first surface while being opposed against the surface to be inspected of the semiconductor wafer and the probes 104 and 104 fitted to the first surface and brought into contact with the pad for inspection fitted to the surface to be inspected of the semiconductor wafer. The probe card concretely has projections 105, 106, 107 and 108 formed at a center and a periphery in the first surface so as to be projected from the first surface so that the expansion and contraction of the card body 101 due to a temperature change can be detected.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008143988-A (JP)
Title: Thermoplastic resin composition for extrusion molding comprising recycled pet and molded product
Inventor: KAWABATA SHUICHI
IPC: B29B17/04
Filed: 2006-12-07
Abstract: <P>PROBLEM TO BE SOLVED: To provide a thermoplastic resin composition using a recycled PET resin and improving impact resistance and extrusion processability which are considered as disadvantages thereof and to provide a molded product thereof.  <P>SOLUTION: The thermoplastic resin composition having the excellent impact resistance and good extrusion processability is obtained by mixing the recycled PET resin mainly of a bottle with a modified olefin resin having a functional group in a prescribed proportion and further adding a prescribed amount of a homopolymer of an unsaturated epoxy compound or a copolymer of the unsaturated epoxy compound with components composed of an aromatic vinyl compound and an ethylenically unsaturated compound. The molded product thereof is obtained.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2007180534-A (JP)
Title: Composition for polishing semiconductor layer
Inventor: BIAN JINRU
IPC: H01L21/304
Filed: 2006-12-13
Abstract: <P>PROBLEM TO BE SOLVED: To provide a polishing composition by which controlled removal for a silicon oxide-contained layer is possible, because slurries that remove a silicon oxide-containing material at a high removal rates has a tendency to also remove underlying masks and a cap and the uncontrolled removal of these underlying layers has an adverse impact upon final performance of an integrated circuit.  <P>SOLUTION: This aqueous polishing composition is useful for polishing a semiconductor substrate. The polishing composition includes 0.05 to 50 wt.% abrasive grains and 0.001 to 2 wt.% λ type carrageenan. The λ type carrageenan has a concentration useful for accelerating TEOS removal rate.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Patent JP-2008148597-A (JP)
Title: Cooking material for fried rice
Inventor: KOSUGI TOMOKO
IPC: A23L27/00
Filed: 2006-12-15
Abstract: <P>PROBLEM TO BE SOLVED: To provide a cooking material for fried rice, free from the need of skill and much time of cooking, allowing ingredients to evenly disperse in cooked rice, having even seasoning, making cooked rice unsticky and sparsely get loose so as to finely fry, and having a set of a dry ingredient part and a liquid seasoning liquid allowing to reproduce proper fried rice with excellent flavor like fried rice served in a specialty store.  <P>SOLUTION: This cooking material for the fried rice is obtained by separately packaging a dry ingredient part comprising at least one dry food and emulsifier mixed powder oil-and-fat, and a liquid seasoning part comprising oil-and-fat seasoning and liquid seasoning.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008148872-A (JP)
Title: Game machine offering bonus game
Inventor: YOSHIZAWA KAZUMASA
IPC: A63F5/04
Filed: 2006-12-15
Abstract: <P>PROBLEM TO BE SOLVED: To provide a game machine which offers new bonus games so far unavailable by enhancing entertaining potentialities in the bonus games.  <P>SOLUTION: In a free game, the number of times of a unit game in which symbols of "ORANGE" is rearranged through a display window W2 is displayed by the symbols of "ORANGE" on a display part 202 for the number of times of stopping of a liquid crystal panel 5B. On the other hand, the amount of dividends acquired from each unit game is added up and displayed on a cumulative added value display part 201. When the prescribed number of times of the unit game is ended, a prescribed multiple for the free game is determined according to the number of the symbols of "ORANGE" displayed on the stop count display part 202 and the amount of dividends added up and displayed on the cumulative added value display part 201 is multiplied by the prescribed multiple determined to determine the final amount of dividends for the free game.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008148948-A (JP)
Title: Music reproducing apparatus and its control method
Inventor: SONODA ARINORI
IPC: A61B5/0245
Filed: 2006-12-18
Abstract: <P>PROBLEM TO BE SOLVED: To select optimum music in order to enhance the degree of relaxation in consideration of biological information and condition during measurement.  <P>SOLUTION: The control method of a music reproducing apparatus includes: a process (step S404) of detecting the pulsation of a person to be measured and calculating a comfort degree indicating the degree of relaxation of the person to be measured on the basis of the dispersion of Lorentz plot data calculated within a prescribed time, brain waves of the person to be measured detected within the prescribed time and a pulse rate per unit time of the detected pulsation; a determination process (step S405) of determining the future state of the person to be measured on the basis of information relating to a weather condition and the comfort degree; and a process (S407) of selecting and outputting music data on the basis of a determined result in the judgement process.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008160398-A (JP)
Title: Moving image coding device, and moving image coding method
Inventor: ARIMURA KOJI
IPC: H04N19/70
Filed: 2006-12-22
Abstract: <P>PROBLEM TO BE SOLVED: To utilize coding parameters of MPEG2 when determining coding parameters newly introduced in H.264.  <P>SOLUTION: A moving image coding device includes: a decoding part 10 for decoding MPEG2 streams; a coding parameter extraction part 11 for extracting a coding parameter of MPEG2 from the MPEG2 streams; a coding parameter re-determination part 12 for determining the strength of correlation between image data coded by MPEG2 and its reference image on the basis of the coding parameter of MPEG2 extracted by the coding parameter extraction part 11 and determining a coding parameter of H.264 on the basis of the determination result; and a coding part 13 for using the coding parameter of H.264 determined by the coding parameter re-determination part 12 to code image data decoded by the decoding part 10, by H.264.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2007210327-A (JP)
Title: Inkjet recording device
Inventor: MOROOKA YOSHIKI
IPC: B41J2/01
Filed: 2006-12-25
Abstract: <P>PROBLEM TO BE SOLVED: To execute a complementary recording operation with a simple constitution without causing a drastic degradation of a recording speed even when a nozzle of poor discharge occurs in one recording head in an inkjet recording device that forms an image while dividing image data corresponding to a plurality of the recording heads by using a plurality of line type inkjet recording heads to one color ink.  <P>SOLUTION: When there is a nozzle of poor ink discharge in one recording head (102), the recording operation of which the nozzle takes charge is complemented by the corresponding nozzle of other recording head (for example, an auxiliary recording head 114). On that occasion, the same split image data are supplied to the one recording head and the other recording head. The recording action is made invalid to the one recording head only at the timing that the nozzle of poor discharge is driven. The recording action is made valid to the other recording head only at the timing that the corresponding nozzle is driven.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Patent JP-2008155590-A (JP)
Title: Weather-resistant film
Inventor: SAITO NOBUO
IPC: B32B27/32
Filed: 2006-12-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide a film formed of a substrate composed of non-vinyl chloride resin and having excellent weather resistance and scratch resistance.  <P>SOLUTION: The weather-resistant film has a primer layer and a surface protective layer provided on the substrate. The substrate is composed of an olefine film. The primer layer contains carbon black. The surface protective layer is composed by crosslinking and curing an electron beam-curable resin composition.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008109833-A (JP)
Title: Electric cart
Inventor: IWANO HARUO
IPC: B60L15/20
Filed: 2006-12-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide an electric cart having a constitution where the cornering performance of which can be enhanced.  <P>SOLUTION: The electric cart is equipped with a yaw moment calculating section 43 that calculates yaw moment YM from tire side forces Fya, Fyb of each of rear wheels 5a, 5b calculated by a tire side-force calculating section 39 and tire fore and aft forces Fxa, Fxb of each of rear wheels 5a, 5b calculated by a tire fore and aft force calculating section 41; a motor torque command value calculating section 45 that calculates a first motor torque command value TP1 of a fist electric motor 7 and a second motor torque command value TP2 of a second electric motor 11 so as to eliminate the difference between the calculated yaw moment YM and a target yaw moment GYM; and a motor control section 47, that controls the first motor 7 and the second motor 11, based on the calculated first motor torque command value TP1 and the second motor torque command value TP2.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008163580-A (JP)
Title: Main bar for grating made of composite resin material and its manufacturing method
Inventor: KOBAYASHI MASAKAZU
IPC: E03F5/06
Filed: 2006-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a main bar for grating made of a composite resin material and its manufacturing method for preventing interlayer exfoliation.  <P>SOLUTION: This main bar 2 is constituted by arranging a rigid resin material 73 and a flexible resin material 74 on a center side and an outer side, respectively, and is molded by extrusion in a mixed condition of both resin materials 73, 74 without forming a boundary face between both resin materials 73 and 74. This main bar 2 is manufactured as follows. That is, the rigid resin material 73 heated to have fluidity is poured into an extrusion molding passage 52 formed in an extrusion mold 50, the rigid resin material 73 is pushed out outside the extrusion mold 50 through a discharge port 62 for extrusion provided in the extrusion molding passage 52, and the flexible resin material 74 having fluidity is poured into an outer surface of the rigid resin material 73 on the downstream side of the rigid resin material 73 flowing in the extrusion molding passage 52 to form the mixed condition of both resin materials 73, 74 without forming the boundary face between both resin materials 73 and 74.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008162727-A (JP)
Title: Conveyor belt
Inventor: FUJITA MAMORU
IPC: B65G15/42
Filed: 2006-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a conveyor belt having a long service life.  <P>SOLUTION: This conveyor belt 1 comprises a belt body 2 and ear parts (waved stiffeners 4) so formed along the longitudinal direction B of the belt body 2 that project from belt surfaces (front belt surfaces 5) positioned at both sides 7, 7 of the belt body 2 in the lateral direction A apart a predetermined distance a from each other in the direction of the belt body 2 in the lateral direction A. A rubber body 15 is installed on each belt surface between each ear part and the side edge 6 of the belt body 2.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2008166580-A (JP)
Title: Ignition coil for multiple ignition
Inventor: NAKAMURA KAZUHIRO
IPC: F02P15/10
Filed: 2006-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide an ignition structure having optimum ignition conditions and control thereof in a combustion engine of a multiple ignition system.  <P>SOLUTION: The ignition coil for multiple ignition has a structure in which a closed magnetic circuit is constituted by a center core formed by laminating silicon steel thin plates and an outer circumferential core formed by laminating silicon steel thin plates, a primary coil formed by coaxially winding a primary copper wire and a secondary core formed by winding a secondary copper wire are disposed on the center core, the primary coil and the secondary coil are housed in a case, and a magnet is attached on an air gap provided between a center iron core and an outer circumferential iron core in the combustion engine ignition coil injection-molded with an insulating resin.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-2006516558-A (JP)
Title: 耳科学的送達装置
IPC: A61P23/00
Filed: 2004-01-14
Abstract: 本発明は、少なくとも1種の薬学的活性剤を含んでなる耳科学的送達装置に関する。本発明によれば、この装置は、少なくとも1種の薬学的活性剤を含んでなるコアと、前記コアを包む膜とを含んでなり、ここで前記コアはポリ(ジメチルシロキサン) 、シロキサン単位のSi原子に結合した3,3,3-トリフルオロプロピル基を含んでなるシロキサンをベースとするエラストマー、ポリ(アルキレンオキシド) 基を含んでなるシロキサンをベースとするエラストマーおよびそれらの混合物から成る群から選択されるエラストマー組成物から作られており、そして前記膜は前記コアと同一であるか、あるいは異なるエラストマー組成物から作られており、前記エラストマー組成物はポリ(ジメチルシロキサン) 、シロキサン単位のSi原子に結合した3,3,3-トリフルオロプロピル基を含んでなるシロキサンをベースとするエラストマー、ポリ(アルキレンオキシド) 基を含んでなるシロキサンをベースとするエラストマーおよびそれらの混合物から成る群から選択される。本発明は、薬学的活性剤が抗アレルギー剤、抗炎症剤、抗真菌剤、グルココルチコイドおよびそれらの混合物を含んでなる群から選択される。
Patent JP-2006515820-A (JP)
Title: タイヤへの剛性要素の固定
IPC: B60C23/06
Filed: 2004-01-19
Abstract: 本発明は、表面の少なくとも一部に設けられた少なくとも１つの表面取付け要素を有するタイヤ（１）において、上記表面取付け要素は、空気と接触状態にあって、上記表面取付け要素（８）の上層を構成する第１の層（９）と、タイヤ（１）と接触状態にあって、上記表面取付け要素（８）の下層を構成する第２の層（１０）とを有することを特徴とするタイヤに関する。表面取付け要素（８）の下層（１０）は、フォームで作られている。上層（９）は、剛性要素及び（又は）着色するのがよいが、そうでなくてもよく、或いはタイヤ用の測定装置又は制御装置であってもよいマーキング被膜又は覆いから成るのがよい。剛性要素及び（又は）覆いは、本発明の表面取付け要素を用いて剛性要素及び（又は）覆いを固定することにより、改良されたやり方でタイヤに取付け可能である。取付け状態は長持ちし、上記剛性要素及び（又は）覆いの特徴は保持される。
Patent JP-2006516568-A (JP)
Title: 加齢関連性障害を処置するための組成物および方法
IPC: A61K35/54
Filed: 2004-01-02
Abstract: 加齢関連性の肉体的障害および精神的障害の処置および予防のための組成物が提供され、この組成物は、約６日齢〜約１４日齢の間で成熟させたニワトリ胚から抽出されたリン脂質を含有する。これらのリン脂質を抽出するための方法もまた提供され、この方法は、約６日齢〜約１４日齢の間にわたって、そのニワトリ胚を孵卵することによる。そのニワトリ胚を、次いで、化学的抽出用に調製し、その脂質を、そのニワトリ胚から抽出する。加齢関連性の肉体的障害および精神的障害の処置を必要とするヒト被験体において、加齢関連性の肉体的障害および精神的障害を予防および処置するための方法がさらに提供され、この方法は、約６日〜約１４日の間にわたって孵卵されたニワトリ胚から抽出されたリン脂質を含む組成物の十分な投薬量をヒト被験体に投与することによる。
Patent JP-2006516777-A (JP)
Title: 信号処理システム
IPC: G06F13/42
Filed: 2004-01-28
Abstract: 第１信号路、第２信号路、第３信号路、及び第４信号路から成るデータバスを有する信号処理システム。第１制御手段は、第１動作モードにおいて、クロック信号が存在しているときに、制御信号の第１の状態を発生させる。第１動作モードは民生電子機器の通常動作モードとしてよい。第２制御手段は、第２動作モードにおいて、クロック信号が存在しているときに、制御信号の第２の状態を発生させる。第２動作モードは民生電子機器の待機モードとしてよい。
Patent JP-2006518966-A (JP)
Title: 重み付けされたｌｓｂ／ｕｓｂの和を用いて干渉を軽減するコヒーレントａｍ復調器
IPC: H03D1/04
Filed: 2004-01-29
Abstract: ＡＭラジオ信号の処理方法は、上側波帯部分と下側波帯部分とを有するＡＭラジオ信号を受信し、上側波帯部分及び下側波帯部分を復調して復調済み上側波帯信号及び下側波帯信号を発生させ、ノイズ電力に応答して復調済み上側波帯信号及び復調済み下側波帯信号に重み付けすることによって重み付けされた復調済み上側波帯信号及び重み付けされた復調済み下側波帯信号を発生させ、重み付けされた復調済み上側波帯信号と重み付けされた復調済み下側波帯信号とを結合して出力信号を発生させるステップより成る。その方法に従ってＡＭ信号を処理する復調器及び復調器を組み込んだ受信機も包含される。
Patent JP-2006516871-A (JP)
IPC: H04W16/14
Filed: 2004-02-02
Abstract: A transmitter directed, distributed receiver using multi-user diversity provided by the distribution of the receiver. Advantage is taken of the uncorrelated variations over time in the condition of communication links between a common transmitter and several users. The greater the variation in the quality of a particular link over time, the greater the increase in total system throughput provided. An scheduler metric (or scheduler metric) represents the instantaneous quality of the communication link between each user and the transmitter with respect to the average quality of the link. Alternatively, the scheduler metric represents the instantaneous channel condition with respect to the average data throughput over that channel. The common transmitting station uses the scheduler metric to directly compare the desirability of granting each channel access with the desirability of granting each other channel access. The users with links that have the greatest scheduler metric are provided access to the channels.
Patent JP-2006520628-A (JP)
IPC: A61M39/00
Filed: 2004-03-09
Abstract: A catheter (1) or needle fastening consisting of a housing (5), e.g. of molded plastic, with two chambers, a cover (6) and a base (7) that surrounds the housing and is fixed to patient's skin, is new. The catheter (1) or needle fastening consists of a housing (5), e.g. of molded plastic, with two chambers, a cover (6) and a base (7) that surrounds the housing and is fixed to patient's skin. The two chambers are in communication with one another, the first being located above the puncture site, and the second receiving a catheter or needle base (3) connected to an external tube (4). The catheter or needle base (3) is in the form of a small reservoir connected to the external tube, while the housing is flat in shape and projects only a small distance from its own base (7). The cover has two projecting pads (13) on its inner surface that fit on either side of the catheter or needle base when the cover is closed to hold it in place.
Patent JP-2006522297-A (JP)
Title: 加圧ガスシリンダ、特に酸素シリンダに対して使用するバルブ構造体並びにバルブとレギュレータの組合せ
IPC: G05D16/10
Filed: 2004-03-30
Abstract: 高圧ゾーン（４２）と低圧ゾーン（４３）との間でガス流を規制するバルブであって、第１チャンバ（２８）と第２チャンバ（２７）を有した中空本体（２０）を含んでいる。本体（２０）内のノズル（３０）は第１チャンバと第２チャンバとを分離し、中間にガス通路を形成する。バルブステム（２１）は通路内を可動であり、第１チャンバ内に少なくとも部分的に延び入る先方ステム部（２２）と第２チャンバ内に形成された基ステム部（２３）とを含んでいる。Ｏリングシート体（２４）はノズル（３０）と接触し、ガス通路を閉鎖する。基ステム部はステム（１７）とガイドピン（３５）と協調するネジ式バレル（３１）を含んでおり、ステムによりバルブを開閉させる。
Patent JP-2007527782-A (JP)
IPC: A24B15/28
Filed: 2004-06-10
Abstract: Cut filler compositions, cigarettes, methods for making cigarettes and methods for smoking cigarettes are provided, which involve the use of a catalyst capable converting carbon monoxide to carbon dioxide and/or nitric oxide to nitrogen. Cut filler compositions comprise tobacco and at least one catalyst. Cigarettes are provided, which comprise a cut filler having at least one catalyst. The catalyst comprises nanoscale metal and/or metal oxide particles supported on a fibrous support. The catalyst can be prepared by combining a dispersion of nanoscale particles with a fibrous support, or by combining a metal precursor solution with a fibrous support and then heat treating the fibrous support.
Patent JP-2007524629-A (JP)
IPC: A61M1/16
Filed: 2004-06-24
Abstract: Acid concentrates, and dialysate compositions prepared therefrom, contain citric acid and an effective amount of a buffering agent selected from acetate and/or lactate. The buffering agent allows a physiologically acceptable amount of citrate to maintain the desired pH of the dialysate.
Patent JP-2007528847-A (JP)
Title: 通常の細胞保護活性を有するが抗凝固活性が低下した活性化プロテインｃ変異体
IPC: A61K38/36
Filed: 2004-07-08
Abstract: 抗凝固活性は実質的に減少しているが抗アポトーシス活性は正常な値を維持している、組換え型活性化プロテインC（APC）の変異体（変異型）または組換え型プロテインC（プロドラッグ、APCに変換可能）が提供される。このような組換え型APC変異型の2つの例は3K3A-APCおよび229/230-APCである。本発明のAPC変異体およびプロドラッグは細胞保護的な望ましい特性（抗アポトーシス作用）を有するが、出血のリスクは著しく減少している。本発明は、APCの抗凝固活性に依存しないAPCの細胞保護活性から恩典を受けると考えられる被験体を治療するための本発明のAPC変異体またはプロドラッグの使用方法も提供する。これらの被験体には、少なくとも一部がアポトーシスによって引き起こされる、血管または各種臓器の組織に対する損傷のリスクを有する患者が含まれる。リスクを有する患者には、例えば、（重度）敗血症、虚血／再灌流性損傷、虚血性発作、急性心筋梗塞、急性もしくは慢性神経変性疾患の患者、または、その他の状態の中でも、臓器移植もしくは化学療法を受けている患者が含まれる。本発明に従って有用である組換え型プロテインCまたはAPCの変異体のスクリーニングの方法も提供される。