baber/WOPTO huggingface dataset:
Patent CA-2403420-A1 (CA)
Title: Compounds capable of binding with the cytoskeleton
Inventor: MURAKAMI KOICHI
IPC: A61P25/00
Filed: 2001-03-19
Abstract: The invention concerns the use of steroids and non-toxic compounds, capable of crossing the blood brain barrier characterised in that they are capable of binding the same site as pregnenolone on proteins constituting or associated with elements of the cytoskeleton and of displacing the MAP-bound pregnenolone, and of influencing the assembling and stabilisation of microtubules. The invention is particularly useful for treating the nervous system, for fighting against ageing of cells containing MAP¿s?, and for treating cancers.
Patent CA-2405831-A1 (CA)
Title: An ergonomic snack piece having improved dip containment
Inventor: TERAS LEE MICHAEL
IPC: A23L1/164
Filed: 2001-05-08
Abstract: The present invention includes an ergonomic snack piece having improved hand  held characteristics and dip containment and a method to make such a snack piece. More particularly, the present invention relates to a ergonomic snack  piece that optimizes an engagement angle and hold angle of the snack piece. Even more particularly, the present invention relates to a snack piece havin g a dip containment well and a grip region that provides improved dip-condimen t retention while simultaneously providing the user areas to hold the chip and  thus avoiding messy finger contact with the dip.
Patent CA-2406261-A1 (CA)
Inventor: SHINMURA MIYUKI
IPC: A61P29/00
Filed: 2001-04-17
Abstract: L'invention concerne une pièce contenant un agent anti-inflammatoire, qui se compose comme suit: 5 à 40 % en poids d'un copolymère bloc de styrène/isoprène/styrène, 1 à 25 % en poids de poly-isobutylène de masse moléculaire élevée, 0,5 à 24 % en poids de poly-isobutylène de faible masse moléculaire, 3 à 50 % en poids d'agent collant, 20 à 70 % en poids de plastifiant, 0,01 à 7 % en poids de dispersant, et 0,1 à 8 % en poids d'un agent anti-inflammatoire contenant un groupe carboxyle ou un sel de ce dernier. La pièce ne contient pas de 1-menthol. Soumise à l'essai de libération d'eau au moyen d'un cylindre rotatif, conformément au procédé d'essai de libération de la pharmacopée des Etats-Unis, ladite pièce présente des taux de libération de médicament de 20 à 64 % en poids et de 40 à 93 % en poids mesurés à une heure et trois heures, respectivement, après le lancement de l'essai.
Patent CA-2406872-A1 (CA)
Title: A process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives
Inventor: RIPA GIORGIO
IPC: C07B61/00
Filed: 2001-04-10
Abstract: A process for the preparation of compound of formula (IA), decahedra-2a,4a,6a,8a-tetraazaccyclopent[fg]acenaphthylene and the corresponding functionalised compounds of general formula (I), which comprises 2 steps; a) the preparation of compounds of general formula (III) and b) subsequent reduction thereof. R are both hydrogen, or one is hydrogen and the other is a straight or branched C1-C4 alkyl group, optionally substituted with one or more -OPg- protected groups, in which Pg is a hydroxy - protecting group. Y1 or Y2 is -CH2-CH2 and the other is -Co-Co- or a group of formula -COCHR, wherein R has the meaning defined above.
Patent CA-2412998-A1 (CA)
Inventor: KOUSTENI STAVROULA
IPC: C12Q1/68
Filed: 2001-06-13
Abstract: This invention concerns the fundamental discovery of the understanding of the mechanism of action of steroidal nongenotropic effects and their relation to steroidal genotropic effects. It has been discovered that (i) steroidal nongenotropic effects and genotropic effects can be mediated by the same steroid receptor; (ii) both effects are ligand-induced; (iii) the nongenotropic effect occurs due to a ligand-induced activation of the ligand binding domain, which can be fast and loose fitting, (iv) the genotropic effect occurs due to a ligand-induced activation of the DNA-binding domain of the steroid receptor, which is typically a result of a slower, stronger interaction; and (v) the nongenotropic effect of a ligand interaction can be associated from the genotropic effect of a ligand interaction, in such a manner to effect a selective response. This invention also describes, for the first time, that certain steroids are capable of inducing a nongenotropic effect via binding to an unrelated steroid receptor.
Patent CA-2413218-A1 (CA)
Inventor: WISNIEWSKI MICHAL P
IPC: H04B10/07
Filed: 2002-11-29
Abstract: A flash optical performance monitor for monitoring DWDM channels is disclosed.  The monitor is to assess the spectral quality of light received and to determine from changes in the spectral quality, relative to a known spectral quality indicative of an acceptable signal, an estimate of signal quality. The flash optical performance monitor comprises a spectrometric transducer for performing a spectral decomposition of the light received, and for transforming the decomposed optical signal into electrical-domain data, a memory for storing advanced digital signal processing routines, and a processor in connection with the wavelength optical unit and with the memory. The processor receives the advanced digital signal processing routines and the electrical spectral data, and applies the advanced digital signal processing routines to the electrical spectral data. Also disclosed a method for monitoring a quality of data transmission of at least one optical channel. The method comprises the steps of capturing a spectrum of a light signal transmitted on the at least one optical channel at an instance in time, providing a spectrum of a time-domain signal, performing an analysis of the spectrum to determine a quality of the light signal, and determine from the quality of the light signal a quality of data transmission.
Patent CA-2414514-A1 (CA)
Inventor: FARRERONS GALLEMI CARLES
IPC: G03B27/02
Filed: 2001-06-25
Abstract: L'invention concerne des carbamates représentés par la formule générale (I), dans laquelle R1, R2 et R3 sont H, OH, SH, CN, F, CI, Br, I, alkyltio (C¿1?-C¿4?), alcoxyle (C¿1?-C¿4?), alcoxyle (C¿1?-C¿4?) substitué par un ou plusieurs radicaux F, carbamylamine, alkyle (C¿1?-¿4?) et alkyle (C¿1?-C¿4?) substitué par un ou plusieurs radicaux F ou OH; R4 est un radical cycloalkylique ou arylique (hétéroarylique ou pas), avec ou sans substitution. L'amine de l'anneau de quinuclidine peut, de plus, former des sels d'ammonium quaternaire, ou se trouver dans un état oxydé (N-oxyde). Les carbamates (I) sont des antagonistes du récepteur muscarinique M¿3?, de manière sélective face au récepteur M¿2?, et peuvent ainsi être utilisés dans le traitement de l'incontinence urinaire (en particulier celle associée à l'instabilité vésicale), dans le traitement du syndrome du côlon irritable, et dans le traitement des maladies des voies respiratoires (en particulier la bronchopneumopathie chronique obstructive, la bronchite chronique, l'asthme, l'emphysème et la rhinite), ainsi que dans les interventions ophtalmiques.
Patent CA-2414520-A1 (CA)
Inventor: APPS MARTIN
IPC: A63F3/04
Filed: 2002-12-23
Abstract: The invention is composed of two parts;   An application to allow an individual to play a crossword puzzle game on a Tablet PC, dependent on a hardware device and operating platform that accepts written data input from a pen or stylus via the visual interface.   A server based application that "hosts" the crossword puzzle. The application accept uploaded data, calculates and configures the wordspaces of the crossword puzzle, and designs and displays the end-use crossword puzzle game for the visual interface on Tablet PC.
Patent CA-2414598-A1 (CA)
Inventor: KOUMARIANOS TEDDY A
IPC: A23L7/10
Filed: 2002-12-16
Abstract: A food additive composition in an all-in-one powder composition containing multiple vitamins, calcium citrate, minerals, herbs, beans, peas, grains, flakes, and berries. The composition is prepared by forming a mixture of the ground beans and peas with the grains, spices, herbs, and vitamins. The mixture is steamed and baked in an oven. three different composition are formulated. The nutritious and flavorful additive composition can be added to food being cooked or while eating out.
Patent CA-2415485-A1 (CA)
Title: Systems and methods for managing drivers in a computing system
Inventor: MILLER JAMES
IPC: G06F9/45
Filed: 2002-12-31
Abstract: Managed code, including applications, runtime, and driver, have a priori knowledge of the client's exact hardware configuration, just as the JIT compiler has a priori knowledge of the microprocessor type on the target computer system. At compile time, the compiler knows the effective version various system drivers, so that the compiler can emit an executable tuned for a particular driver version and target system.
Patent CA-2419445-A1 (CA)
Inventor: PREIDEL WALTER
IPC: H01M8/04186
Filed: 2001-07-31
Abstract: The aim of the invention is to remove carbon dioxide from a water/fuel mixture, especially in a fuel cell. To this end, a separation installation that works according to the principle of the fuel cell is used for removing the carbon dioxide with the help of a fuel- and water-permeable membrane. The corresponding device comprises a fuel cell unit that is used as the separation installation and that forms part of the entire installation.
Patent CA-2419621-A1 (CA)
Title: Copolyester with high carboxyl end groups and a method for making
Inventor: HUANG XIAOYAN
IPC: C08G63/183
Filed: 2001-06-20
Abstract: The present invention relates to a composition comprising: a copolyester of polyethylene terephthalate and a dicarboxylic acid or its ester equivalent, and not more than 100 microequivalents per gram of said copolyester of an anhydride selected from the class consisting of succinic, glutaric, benzoic, maleic and phthalic anhydride, said composition having a CEG content greater than about 25 microequivalents per gram and an IV greater than about 0.65. The present invention also concerns a method of making a composition having reduced caustic stress cracking, comprising: reacting terephthalic acid or its ester equivalent and another dicarboxylic acid with ethylene glycol by esterification followed by polycondensation to make a polyethylene terephthalate copolyester; adding at the end of said polycondensation not more than 100 microequivalents per gram based on said copolyester of an anhydride selected from the class consisting of succinic, glutaric, maleic, benzoic, and phthalic anhydride, said composition having a CEG content greater than about 25 microequivalents per gram.
Patent CA-2423025-A1 (CA)
Title: New dipeptidyl peptidase iv inhibitors and their uses for lowering blood pressure levels
Inventor: HOFFMANN MATTHIAS
IPC: C07D277/04
Filed: 2002-07-23
Abstract: The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition  salt forms, for lowering blood pressure levels.
Patent CA-2423747-A1 (CA)
Title: High resolution pigment ink for impulse ink jet printing
Inventor: SALISBURY BRIAN
IPC: B41J2/01
Filed: 2003-03-26
Abstract: Impulse ink jet compositions are provided which are suitable for printing clear, well-defined alphanumeric text or low spread, narrow bar width bar codes on porous substrates such as Kraft paper or corrugated cardboard. The inks preferably contain an antioxidant that lowers the dissolved oxygen level in the ink, thereby enhancing the jetting performance of the printhead.
Patent CA-2423792-A1 (CA)
Title: Alpha-aryl ethanolamines and their use as beta-3 adrenergic receptor agonists
Inventor: LAFONTAINE JENNIFER ANNE
IPC: C07D271/06
Filed: 2001-10-04
Abstract: The instant invention provides beta3 adrenergic receptor agonists of structural Formula (I), wherein Ar is pyridyl, oxazolyl, thiazolyl or phenyl;  Rs is a S- or 6- membered heterocycle; X is a direct bond or oxygen; and Y is a direct bond, alkylene, OCH2, CH2O or oxygen; the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs. The invention further provides intermediates useful in the preparation of the compounds of Formula (I), and combinations of the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, with anti-obesity agents.
Patent CA-2425126-A1 (CA)
Inventor: ARVIZU CHANDRA
IPC: A61P31/04
Filed: 2001-10-05
Abstract: La présente invention concerne des enzymes du métabolisme lipidique humain (EML) et des polynucléotides qui identifient et codent l' EML. Ladite invention concerne aussi des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes, et des antagonistes. Ladite invention concerne également des méthodes permettant de diagnostiquer, traiter, ou prévenir les troubles liés à une expression aberrante d' EML.
Patent CA-2425244-A1 (CA)
Inventor: KREBS BODO
IPC: G01T1/167
Filed: 2001-10-04
Abstract: The invention relates to a method for detecting, when measuring radioactivit y, when a predetermined threshold value is exceeded, comprising the following steps: a) calculating an overall measuring interval for a contamination measuring device, b) carrying out with said measuring device several individual measurements that have a measuring interval that is shorter than the overall measuring interval, c) after every individual measurement, calculating, on the basis of the values measured so far, a probability for t he fact that with one or more individual measurements across a time interval th e average value from all individual measurements will exceed the threshold value, the time interval being at least as long as the time interval remaini ng until the overall measuring interval is reached, d) for the case that the calculated probability is smaller or equal a predetermined certainty describing that the threshold value will be exceeded in the remaining measuring interval, producing a signal according to which the threshold valu e is not exceeded and the method is terminated, otherwise, carrying out furthe r individual measurements either until the overall measuring interval is reach ed or exceeded or until the calculated probability for an individual measuremen t is smaller or equal the predetermined threshold probability and the method i s terminated.
Patent CA-2425600-A1 (CA)
Title: Optical waveguides with trench structures
Inventor: POPOVIC MILOV
IPC: G02B6/136
Filed: 2001-10-15
Abstract: Arrangements using air trench cladding enables minimization of the evanescen t tail to suppress light coupling to radiation modes, resulting in low-loss bends and splitters. Structures including sharp dends and T-splitters withou t transmission loss, crossings without crosstalk, and couplers from/to fibers and without-of-plane waveguides without substantial loss are provided with such air trench claddings. Air trench sidewall cladding of waveguides pushes  evanescent tails toward top and bottom claddings to enhance coupling between  vertically positioned waveguides. Fabrication processes using wafer bonding technology are also provided.
Patent CA-2432827-A1 (CA)
Inventor: GAONKAR ANILKUMAR G
IPC: C11B9/00
Filed: 2001-12-19
Abstract: A coffee aroma composition and a particulate coffee beverage preparation aroma composition. The aroma composition includes a coffee aroma constituent and a volatile organic carrier constituent. The carrier is in the liquid state at 25 ~C, and has a vapor pressure of at least 0.01 mm Hg at 25 ~C, a boiling point in the range of 25 to 250 ~C, a density of less than 1.0 g/cc, and water solubility of not more than about 10% by weight at 25 ~C.
Patent CA-2436056-A1 (CA)
Title: Electromagnetic borehole surveying method
Inventor: PITZER RAHN
IPC: E21B47/022
Filed: 2002-02-07
Abstract: An apparatus and method for surveying the path of a borehole includes two single-axis field sensors (42) located at a radius centered at a fixed location. Guide wires (26, 28, 30) are located along the earth's surface above the prescribed borehole path (22) and the known electromagnetic field produced by current in the guide wires are detected by the sensors (42). Values of X  and Y at multiple locations on a spherical surface at the radial distance of the sensors are calculated and compared with measured values to define the location of the sensors (42) on the spherical surface to permit the lateral spacing between the sensors (42) and the desired borehole path (22) to be determined.
Patent CA-2437870-A1 (CA)
Title: Hydrogels reticules par rayonnements
Inventor: CRUISE GREGORY M
IPC: A61L27/18
Filed: 2002-02-13
Abstract: L'invention concerne des hydrogels synthétiques, biodégradables, réticulés par rayonnements, et leur utilisation dans diverses applications, y compris certaines applications médicales, au cours desquelles les hydrogels sont implantés sur le corps d'un patient humain ou animal ou dans ledit corps. On peut préparer lesdits hydrogels en irradiant des monomères (par exemple, des hydrocarbures non saturés, tels que des monomères acryliques et des monomères méthacryliques) ou des polymères, dont certains sont biodégradables ou contiennent des unités ou des sous-unités biodégradables. Les applications médicales de ces hydrogels synthétiques, biodégradables, réticulés par rayonnements comprennent des applications impliquant l'utilisation de l'hydrogel en cas d'hémostase, d'augmentation cellulaire, d'ingénierie tissulaire, d'embolisation, d'occlusion de ponctions vasculaires ou de blessures, et d'autres applications.
Patent CA-2438720-A1 (CA)
Title: Magnesium alloy material and method of manufacturing the alloy material
Inventor: NISHIKAWA TAICHIRO
IPC: B22D11/00
Filed: 2002-04-01
Abstract: In manufacturing a magnesium alloy, continuous casting is performed using a movable mold.     A magnesium alloy to be processed by presswork, forging, and the like can be efficiently provided.
Patent CA-2439334-A1 (CA)
Title: Encoding semi-structured data for efficient search and browsing
Inventor: SHADMON MOSHE
IPC: G06F17/30
Filed: 2002-02-25
Abstract: A method for encoding XML tree data that includes the step of encoding the semi-structured data into strings of arbitrary length in a way that maintain s non-structural and structural information about the XML data, and enables indexing the encoded XML data in a way that facilitates efficient search and browsing.
Patent CA-2440679-A1 (CA)
Inventor: AMTMANN EBERHARD
IPC: C12N9/16
Filed: 2001-03-06
Abstract: Two novel sphingomyelinases are provided, having optimum activities at pH7 and pH8, respectively. The two proteins have different tissue sources, the pH7 form from e.g. T cell lymphomas, and the pH8 form from e.g. B cell lymphomas.  Methods of treatment and diagnosis, fragments, antibodies, nucleic acids and pharmaceutical compositions are also provided.
Patent CA-2441936-A1 (CA)
Title: Methods and compositions for modulating tumor suppression
Inventor: NAKATANI YOSHIHIRO
IPC: A61K38/00
Filed: 2002-03-25
Abstract: The purification of native RB (retinoblastoma) as a complex, including P107, P130, and a 600 kDa subunit, termed MTAF600 (microtubule associated factor 600) is described. MTAF600 binds to RB regardless of the phosphorylation status of RB, and binds to RB without disrupting the interaction between RB and E2F. It is further shown that E2F and DP proteins co-purified with MTAF6 00 and RB, such that hypophosphorylated RB may gain access to E2F as a complex with MTAF600. In addition, MTAF600 binds to microtubules and plays a role in active repression of E2F-responsive genes, cell cycle arrest, and genomic stability. The sequence of MTAF600 is described herein, along with its bindi ng properties to proteins such as RB and microtubules, and its sequence homolog y. Further, methods and reagents for assaying the presence of MTAF600 or mutant s thereof, pharmaceutical formulations, and methods for treating disease are also described.
Patent CA-2443795-A1 (CA)
Inventor: BELL MICHAL
IPC: C12N9/12
Filed: 2002-04-04
Abstract: The present invention relates to a method of screening for constitutively active mutants of a desired eukaryotic MAPK pathway member of a MAPK pathway member, comprising the steps of (a) providing a mutant yeast strain devoid of an upstream kinase; (b) providing a DNA library of different mutants of a mutagenized gene coding for the desired MAPK pathway member; (c) introducing said library into said yeast strain under conditions suitable for activation of the yeast MAPK pathway; (d) detecting an end-point indication for activation of the yeast pathway; and (e) optionally isolating said constitutively activated mutant from selected rescued clones. The invention further relates to isolated constitutively active mutants of the MAPK pathway member, and their various uses particularly, in a method of screening for substances which are inhibitors of a MAPK pathway, and in drug design.
Patent CA-2444091-A1 (CA)
Inventor: MESHENKY STEVEN P
IPC: F28F9/02
Filed: 2003-10-03
Abstract: A header construction intended for use in a heat exchanger (36) employed in a relatively high pressure application includes an array of generally parallel tube runs (84) with fins (82) extending between adjacent ones of the tube runs. At least one relatively flat header plate (86) has a plurality of tube slots (88) for receiving ends (90) of the tubes (84) and a tank (94) is mounted to and sealed to the header plate (86). Peripheral flanges (112) are located about tube slots (86) in the headers and a header reinforcing plate (114) is bonded to the header plate (86) oppositely of the tank (94). Stiffening beads in the form of flanges (120) are located on the header reinforcing plate (114) between openings (118) therein through which the tubes (84) pass and extend away from the header plate (86).
Patent CA-2446029-A1 (CA)
Title: Well jet device for well testing and development and operating method for said well jet device
Inventor: KHOMYNETS ZINOVIY DMITRIEVICH
IPC: F04F5/46
Filed: 2002-05-28
Abstract: The invention relates to jet devices for extracting oil from wells and intensifying the oil influx rate. An output cone, a packer and a jet pump are mounted on a tubing string.  One or several active nozzles are arranged inside the pump body, and a stepped pass channel provided with a mounting seat for a pressure-sealing unit which is disposed between stages and several channels for supplying a pumped-out medium are embodied inside said pump body. The axes of the nozzles are disposed in a parallel position with respect to the axis of the pass channel at a certain distance therefrom. The inventive device is provided with a radiator and a receiver-transducer of physical fields mounted on a cable in such a way that it is replaceable by other instruments. Said cable passes through the axial channel of the sealing unit which is arranged in such a way that it is successively replaceable by functional inserts such as a testing and depression inserts etc. Said inserts are provided with mechanisms for bringing them to the pump body and for extraction therefrom. Mounting seats for back valves and plugs are embodied in the lower part of the channels for supplying the pumped-out medium. The dimension ratios of the elements of the inventive device are also disclosed. The aim of the invention is to optimise the dimensions of the elements of said device and increase the performance thereof.
Patent CA-2451065-A1 (CA)
Title: Enzymatic method of producing 4-0-beta-d-galactopyranosyl-d-xylose
Inventor: ARAGON REYES JUAN JOSE
IPC: B01D61/14
Filed: 2002-06-14
Abstract: The invention relates to an enzymatic method of producing 4-0-.beta.-D- galactopyranosyl-D-xylose which is used for the in vivo evaluation of intestinal lactase activity in humans. The inventive method consists in: a) reacting D-xilose with a .beta.-D-galactopyranoside for 2 48 h in a medium buffered to pH 5 9 and at a temperature that varies between the freezing of the mixture and 45 ~C, and subsequently adding 10-10,000 units of .beta.-D- galactosidase per gram of .beta.-D-galactopyranoside; b) stopping the reacti on by deactivating the enzyme; and c) isolating and crystallising the fractions that contain 4-O-.beta.-D-galactopyranosyl-D-xilose in a crystallisation mixture selected between acetone/methanol (5:1-20:1) and acetone/water (5:1- 20:1).