baber/WOPTO huggingface dataset:
Patent DE-60031533-D1 (DE)
Inventor: JONES C
IPC: C12Q1/37
Filed: 2000-06-29
Granted: 2006-12-07
Abstract: The DegP (HtrA) protease is a multifunctional protein essential for the removal of misfolded and aggregated proteins in the periplasm. The present invention provides an assay for inhibitors of DegP activity, comprising mixing a suspected inhibitor of DegP activity with DegP and a suitable substrate (preferably a native substrate of DegP such as PapA) and detecting changes in DegP activity. DegP has been shown to be essential for virulence in several Gram negative pathogens. Only three natural targets for DegP have been described: colicin A lysis protein (Cal), pilin subunits (K88, K99, Pap) and recently HMW1 and HMW2 from Hemophilus influenzae. In vitro, DegP has shown weak protease activity on casein and several other non-native substrates. The present inventors have identified the major pilin subunit of the Pap pilus, PapA, as a native DegP substrate and demonstrated binding and proteolysis of this substrate in vitro. Using an NH2-terminal affinity tag the present inventors have purified PapA away from the PapD chaperone, in the presence of denaturant, to use as a proteolysis substrate. This finding will allow the identification of the DegP recognition and cleavage sites in substrate proteins, and further, allow the design of small molecule inhibitors of protease function.
Patent DE-60037069-D1 (DE)
Inventor: HIRASHIMA YUTAKA
IPC: H05K3/38
Filed: 2000-05-23
Granted: 2007-12-27
Abstract: A circuit substrate which has a ceramic substrate and an Al circuit comprising Al or an Al alloy bonded to said ceramic substrate via a layer comprising Al and Cu. <IMAGE>
Patent DE-60102360-D1 (DE)
Inventor: BERKOOZ ODED
IPC: G05B13/04
Filed: 2001-01-11
Granted: 2004-04-22
Abstract: A controller and method for efficient tracking and optimizing of a machine set-point, to correct for changes in machine characteristics, can include: (a) defining allowed ranges for output product properties and possible machine set-points, and optimal set-point criteria; (b) finding updated constants for the machine model by calibrating the model; (c) using the updated constants to find all set-points providing a product with properties within the allowed ranges; (d) determining an optimized set-point; (e) operating the machine at the optimized set-point, and obtaining a new output product; (f) comparing the properties of the new output product to the allowed ranges; (g) successfully finishing the procedure as finding a new set point if the properties of the output product are within allowed ranges; and, (h) if the properties of the output product are out of said allowed ranges, repeating the procedure from b.
Patent DE-60103159-D1 (DE)
Inventor: BIGOLIN RICCARDO
IPC: B62J1/00
Filed: 2001-07-27
Granted: 2004-06-09
Abstract: Saddle made of composite material, in particular for a bicycle, which comprises a support structure ( 2 ) provided with a padding ( 3 ) having, associated above it, a seating surface ( 7 ). The support structure ( 2 ) comprises a plurality of first layers ( 8 ) of high-rigidity composite material having an opening ( 11 ) formed centrally therein and a second layer ( 9 ) of composite material with a rigidity less than that of the first layers ( 8 ), fixed to the latter along a superimposed surface covering the opening ( 11 ) so as to form an elastically yielding zone which is preferably located in the prostatic and ischiatic zones of the seat ( 7 ) of the saddle ( 1 ).
Patent DE-60107616-D1 (DE)
Inventor: ZUALDI PAOLO
IPC: B07C3/00
Filed: 2001-05-25
Granted: 2005-01-13
Abstract: The present invention relates to a process used to sort out a lot of items loaded in bulk on a conveyor system according to a predefined order. This process is basically characterised by the fact that it includes two different phases to separate the items thanks to the presence on the conveyor system of two groups of exits; it being provided, in particular, that the first separation phase carried out with the first. group of exits is preliminary to the second and final separation phase carried out with the second group of exits, that is the phase that allows to sort out the items according to the predefined order.
Patent DE-60113047-D1 (DE)
Inventor: TRIVINI RUGGERO
IPC: B60B33/02
Filed: 2001-11-30
Granted: 2005-10-06
Abstract: An easily assembled castor wheel for chairs, armchairs and the like, comprises a supporting body (2) defining a seat (3) for housing a vertical pivot pin for coupling the wheel to the chair, and being supported by a pair of adjoining arranged wheels (11), the main feature of the invention is that the wheels (11) comprise removable front cover elements (30). <IMAGE>
Patent DE-60115290-D1 (DE)
Inventor: SPOELSTRA JAN
IPC: B29C70/54
Filed: 2001-09-03
Granted: 2005-12-29
Abstract: A method of manufacturing a composite wheel comprises: (a) building up at least two separate preforms; (b) combining the separate preforms; (c) compressing into one whole; and (d) impregnating the compressed whole with a synthetic resin. The preforms are built up by compressing mats of oriented fibers (5) into each of the respective preform, to form hub (2, 3) and rim (1) portions of the wheel, respectively.
Patent DE-60120360-D1 (DE)
Inventor: CRITON L
IPC: G01S7/52
Filed: 2001-11-23
Granted: 2006-07-20
Abstract: Strain rate analysis is performed for ultrasonic images in which the spatial gradient of velocity is calculated in the direction of tissue motion. Strain rate is calculated for cardiac ultrasound images in the direction of motion which, for myocardial images, may be either in the plane of the myocardium or across the myocardium. Strain rate information is calculated for a sequence of images of a heart cycle and displayed for an automatically drawn border such as the endocardial border over the full heart cycle.
Patent DE-60120699-D1 (DE)
Inventor: YEH POCHI
IPC: G02F1/13363
Filed: 2001-04-24
Granted: 2006-07-27
Abstract: A liquid crystal display which contains a layer of liquid crystal material placed between two plates, a system of electrodes applied to each of said plates, wherein at least one of said plates has at least one O-type polarizing layer and at least one E-type polarizing layer, and the second plate has at least one O-type or E-type polarizing or diffuse or mirror-reflecting layer. <IMAGE>
Patent DE-60127426-D1 (DE)
Inventor: SEVOLA MAURI
IPC: H02K5/173
Filed: 2001-09-17
Granted: 2007-05-03
Abstract: A lubricant discharge device for discharging lubricant from a bearing housing (1) of an electric motor includes a tubular element (3) consisting of components (3a, 3b) arranged at a lubricant discharge opening (2) in the bearing housing. A piston (4) is arranged inside the tubular element (3) being connected to an arm section (5). The tubular element comprises a first end (3d) placed at the grease discharge opening and a second end (3c) that is opposite to the first end and is situated at the outer edge of an end shield of the electric motor. An opening (6) is provided in the casing of the tubular element close to the second end (3c) of the tubular element, and a closing means (7) is arranged inside the tubular element to open and close the opening (6).
Patent DE-60204661-D1 (DE)
Inventor: BACON RAYMOND JOHN
IPC: F16K7/06
Filed: 2002-01-24
Granted: 2005-07-21
Abstract: A breath actuated dispenser there-shown has a generally L-shaped hollow body 1 with a mouthpiece 2. An aerosol drug can 3 is mounted in the body. The can has a dispensing spout 4, which engages a receptor moulding 5 incorporating a living hinge 11, a movable outlet member 8 and a kink valve 9. A flap member 31 is pivotally mounted between the can and the receptor moulding. Breathing in through the dispenser by the patient will cause the flap to be drawn down against its spring 34. The outlet member is then tipped down by the spring 37 to point out of the mouthpiece 2, whence the dose is dispensed by opening of the kink valve.
Patent DE-60204825-D1 (DE)
Inventor: SEMENENKO IVAN
IPC: B65D90/62
Filed: 2002-07-12
Granted: 2005-08-04
Abstract: A through-flow closure for a receptacle (11) of flowable material, the closure comprising a body part (17) having a charging aperture (18) and a closure operating member (20) for opening the closure device (14) of a container (10). There is an annular gap between the edge of the aperture (18) and the closure operating device (14). A stretchable annular sealing member (24) attached to the body part. The sealing member seals the gap between the body part and the closure operating member when the receptacle and container are separated and forms a seal between the body part and the container when the receptacle and the container are moved together and prior to the closure operating member opening the closure device of the container. <IMAGE>
Patent DE-60204917-D1 (DE)
Inventor: TEIXIDOR CASANOVAS PEDRO
IPC: B65D5/00
Filed: 2002-11-14
Granted: 2005-08-04
Abstract: The box, with the option of being made from a single sheet or from five separate pieces which when duly fastened to one another form the box, presents the special feature that at the front ends extensions project with transverse folding lines to form the classic corner reinforcements. The extensions that form these reinforcements present four folding lines(5-6-7-8) that define the sectors (9-10-11-12-13), which in the course of assembly form an initial sector (9) which is attached to the inner face of the side(2), a second sector (10) with a diagonal disposition, a third sector (11) which is attached on the inside of the front (3), a fourth sector (12) which lies at right angles to the diagonal sector (10), and a last sector (13) which is attached to one of the two halves of the inner face of the diagonal sector (10). At their upper edge sectors (10) and (12-13) present flanges(14-15) which will in the course of assembly form projections perpendicular to one another, for positioning in matched opposing notches (16-17) when the boxes are stacked, while on each box the projections formed by the flanges (14-15) are positioned in windows (20) in horizontal upper windows (18) of the fronts (3). <IMAGE> <IMAGE>
Patent DE-60207702-D1 (DE)
Inventor: PIEPEL ANDREW J
IPC: G03B21/62
Filed: 2002-02-11
Granted: 2006-01-05
Abstract: A system for use with a releasable screen is described. The system may be used in a method of influencing purchasing decisions.
Patent DE-60207744-D1 (DE)
Inventor: SMITH A
IPC: A61P9/12
Filed: 2002-09-24
Granted: 2006-01-05
Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
Patent DE-60208397-D1 (DE)
Inventor: GRONER BERND
IPC: A61P43/00
Filed: 2002-09-17
Granted: 2006-02-02
Abstract: The present invention relates to the use of the drug valporic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity for the manufacture of a medicament to sensitize human cancer cells for treatment efficacy in combination with clinically established anti-cancer therapeutic drugs. The invention also relates to the treatment of tumor metastasis and minimal residual disease.
Patent DE-60209866-D1 (DE)
Inventor: RESTANI ERIC
IPC: A63C5/04
Filed: 2002-07-09
Granted: 2006-05-11
Abstract: The alpine ski (1) has a raised section (5) to carry the bindings formed by a thickening in the ski structure. The ski has an insert (12) over a section of the ski length. The insert is positioned between the upper face (6) of the raised section and the edges (9). The exterior surface of the insert is flush with the side faces of the ski. Claims include a method of making the ski
Patent DE-60212369-D1 (DE)
Inventor: EGRETIER JEAN-MICHEL
IPC: B30B9/10
Filed: 2002-04-11
Granted: 2006-07-27
Abstract: The invention concerns a device for pressing packs or bulk containers for recuperating liquids, in particular milk or fruit juice, which they contain. The inventive device is essentially characterised in that it comprises, in combination, a support plate (3), whereon are set the packs to be pressed (4), adapted to take up a high position for pressing the stacked packs (4) and a low position for pressuring the containers; a pressing plate (1), driven in a vertical reciprocating movement, adapted to press said packs or containers and means (2) adapted to delimit, with the plate (1) and the plate (3), a closed volume during the entire pressing phase. The means 82) is a sliding skirt, urged to be supported on the plate (3) when the packs (4) are pressed and a tank, delimited in its base by the plate (3), when the bulk containers are pressed.
Patent DE-60216498-D1 (DE)
Inventor: DETRUIT BERNARD
IPC: A61M31/00
Filed: 2002-11-07
Granted: 2007-01-11
Abstract: The invention concerns a device comprising: a packaging box for the flexible material part, dimensioned to hold said part flat; folding means for folding said part without direct handling; and a reception tube for receiving said folded flexible material part. The invention is characterized in that the folding means comprise; a traction suture connected to the flexible material part, which passes through the tube, and, walls forming a funnel whereof the base emerges proximate to the opening of the tube through which the flexible material part is designed to be inserted into said tube, said funnel being designed, when a traction is exerted on the traction suture, to gradually fold down the zones of the part located laterally relative to the tube towards the zone of the part located opposite the opening of said tube, to enable the part to be inserted into the tube.
Patent DE-60216862-D1 (DE)
Inventor: MAGRET VINCENT
IPC: H04L29/06
Filed: 2002-08-05
Granted: 2007-02-01
Abstract: A micro-mobility network routing system and method implementing a protocol that extends the macro mobility support of Mobile IP to support micro mobility is disclosed which permits a more efficient and easily implemented Internet routing protocol for network devices to be affected. The macro mobility feature herein refers to the notion in which the mobile node gains access to the Internet, while retaining the same IP address. This concept is used only once when the mobile node enters the coverage area of a foreign domain (eventually its home domain). The concept of micro mobility within this context eases routing packets to the mobile node while its moves within the foreign network. The present invention implements these new features via the use of message compositions and protocol extensions that extend the prior art Mobile IP protocols. <IMAGE>
Patent DE-60217312-D1 (DE)
Inventor: HAUSER ALLEN
IPC: C07K14/61
Filed: 2002-03-14
Granted: 2007-02-15
Abstract: The current invention provides methods for molecule purification by RP-LC and RP-HPLC that uses unbranched terminal alkyldiols as eluting solvents. In particular, the present invention purifies molecules, particularly proteins and peptides, on reverse phase liquid chromatography columns using a buffer containing either 1,5 pentanediol, 1,6 hexanediol or 1,7 heptanediol.
Patent DE-60219889-D1 (DE)
Inventor: SOLLIER GHISLAIN
IPC: F16K1/34
Filed: 2002-03-06
Granted: 2007-06-14
Abstract: The invention relates to a device comprising at least one safety shut-off control valve. A safety valve is optionally connected to said safety shut-off control valve, connected in series in the fluid flow path. In the safety shut-off control valve, a sealing valve is returned to a sealing position against a seat by means of a return spring, and is controlled by a linear actuator and a connecting rod for continuous adjustment of the valve opening. The connecting rod comprises two independent segments which are at least partially made from a ferromagnetic material and which are magnetically coupled to a magnetic coupling circuit that is activated by a coil. While electric power is being supplied to the coil, the magnetic field that said coil creates maintains the linking rod segments coupled to one another, such that the linear actuator can control the sealing valve. Once the power being supplied to the operating coil is interrupted, the segments separate and the sealing valve returns to said sealing position regardless of the position of the linear actuator. At the same time, the check valve of the safety valve is pushed back to the sealing position by a return spring. In this way, a continuous control valve with a double safety system is produced.
Patent DE-60222315-D1 (DE)
Inventor: COUTANDIN DANIELE
IPC: F23R3/06
Filed: 2002-04-09
Granted: 2007-10-25
Abstract: A gas turbine combustor (5), in particular for an aircraft engine (1), has at least one chamber (14), through which combustion gas flows in use, and which is defined by a lateral wall (15) with channeling (60) for feeding cooling air into the chamber (14) and cooling the lateral wall (15); part of the channeling (60) is defined by at least one double wall (31, 32, 36) for guiding a relative stream (F1, F2) of cooling air into the chamber (14) in a tangential direction with respect to the lateral wall (15). <IMAGE>
Patent DE-60224087-D1 (DE)
Inventor: TERLET CHRISTOPHER JOHN
IPC: E21B21/12
Filed: 2002-10-30
Granted: 2008-01-24
Abstract: The invention is a transmission sleeve for the reverse circulation down hole hammer activated by fluid under pressure, the hammer including an outer hammer casing, a drill bit retaining means ( 17 ) and a drill bit ( 10 ) retaining means ( 17 ) and extending forwardly therefrom. The transmission sleeve ( 25 ) comprises a transmission sleeve retaining means to retain the transmission sleeve ( 25 ) to the hammer, a flange ( 28 ) to direct exhaust fluid from the hammer extending from the transmission sleeve retaining means towards the cutting face ( 14 ) of the drill bit ( 10 ) so that the exhaust fluid is directed towards the cutting face ( 14 ) and a chamber ( 30 ) that extends circumferentially around the drill bit ( 10 ) into which the exhaust fluid flows prior to discharge from the end of the flange ( 28 ). The chamber ( 30 ) makes it possible for air pressure to be equalized around the periphery of the drill bit ( 10 ) and allows for some air flow from the end of the flange ( 28 ) between the channels ( 31 ) in the drill bit ( 10 ) to provide a curtain of air flow from the flange ( 28 ).
Patent DE-60224732-D1 (DE)
Inventor: HOLLA WOLFGANG
IPC: C07D233/72
Filed: 2002-07-06
Granted: 2008-03-06
Abstract: Production of optically active 2-(2,5-dioxo-1-imidazolidinyl)acetic acid derivatives (I), comprises: (1) enzymatic hydrolysis of a mixture of enantiomers with an esterase: and  (2) separation of the converted and unconverted compounds from each other.  Production of optically active 2-(2,5-dioxo-1-imidazolidinyl)acetic acid derivatives of formula (I), comprises: (1) enzymatic hydrolysis of a mixture of enantiomers of formula (I;R3=R3') with an esterase: and  (2) separation of the converted and unconverted compounds from each other.  R<1> = H, F, or 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl or 3-4C cycloalkyl (optionally substituted by 1-3 of F, Cl, Br and Me); R<1>+R<1> = (CH2)4 or (CH2)5; R<2> = F, Cl, Br, NO2, CN, OH, OMe, acetylamino, t-butoxycarbonylamino, benzyloxycarbonylamino, SMe, t-butylthio, 1-10C alkyl, aryl, aryl(1-10C)alkyl, heteroaryl, heteroaryl(1-10C)alkyl, 2-10C alkenyl, 2-10C alkynyl, 3-7C cycloalkyl or (3-7C)cycloalkyl(1-10C)alkyl optionally substituted with 1-3 of halo, CF3, Me, NO2, CN, acetylamino, 9-fluorenylmethoxycarbonyl, t-butoxycarbonylamino, benzyloxycarbonylamino, SH, SMe, t-butylthio, OH, OMe, OEt or COOR<4>; R<3> = H or R3'; R3' = 1-10C alkyl, aryl(1-10C)alkyl, 2-10C alkenyl, 2-10C alkynyl, 3-7C cycloalkyl or (3-7C)cycloalkyl(1-10C)alkyl optionally substituted with 1-3 of halo, CF3, Me, NO2, CN, acetylamino, t-butoxycarbonylamino, benzyloxycarbonylamino, SH, SMe, t-butylthio, OH, OMe, OEt and COOR<5>; and R<4>, R<5> = H, 1-4C alkyl, 2-4C alkenyl or aryl(1-10C)alkyl.
Patent DE-60224762-D1 (DE)
Inventor: DUBIEF CLAUDE
IPC: C08B31/04
Filed: 2002-10-21
Granted: 2008-03-13
Abstract: Production of polysaccharide betainates (I) comprises either: (a) reacting a polysaccharide with a dialkylamino carboxylic acid (II) in the presence of an activator and quaternizing the resulting ester; or (b) reacting a polysaccharide with a trialkylammonio carboxylic acid (III) in the presence of an activator and a polar aprotic solvent.  Production of polysaccharide betainates of formula (I) comprises either: (a) reacting a polysaccharide with a dialkylamino carboxylic acid of formula (II) in the presence of an activator and quaternizing the resulting ester; or (b) reacting a polysaccharide with a trialkylammonio carboxylic acid of formula (III) in the presence of an activator and a polar aprotic solvent:  R1-R3  = (un)saturated linear or branched 1-30C hydrocarbyl optionally interrupted by heteroatoms (N, O and S) and/or optionally substituted with OH, halo and/or 6-22C aryl; A = (un)saturated linear or branched 1-22C hydrocarbylene optionally interrupted by heteroatoms (N, O and S) and/or optionally substituted with OH;  X  = an anion;  Y  = a polysaccharide. Independent claims are also included for:  (1) (1) compounds (I) other than those where Y is starch, A is methylene and R1-R3 are methyl;  (2) (2) a composition comprising at least one compound as in (1) in a cosmetically or dermatologically acceptable medium;  (3) (3) cosmetic treatment of a keratinic substrate selected fom skin, scalp, hair, eyelashes, eyebrows, nails and mucosa by applying the composition of (2) to the substrate.
Patent DE-60225755-D1 (DE)
Inventor: MCCLURE JOHN R
IPC: A01F15/07
Filed: 2002-06-05
Granted: 2008-05-08
Abstract: An agricultural round baler (1) comprises a mechanism (30) for placing netwrap (41) over the edge of a cylindrical bale that is created in the baling chamber (24a). The mechanism includes a netwrap delivery assembly (50) having of a pair of arms (51) pivotally affixed to the outside of the baling chamber sidewalls (24). The arms hold an assembly frame (54). An actuator (70) controls the pivoting motion of the delivery assembly (50) inserting the netwrap between the stationary dimple roll (8) and the pivot roll (9) of the sledge assembly (26). Positioned outside the sidewall (24) and inside an outer frame member (25) is a transition area (90). The netwrap (41) is inserted between the stationary dimple roll (8) and the pivot roll (9) as well as into the transition area (90). Because the width of the delivery assembly (50) is wider than that of the cylindrical bale, a portion of the netwrap (41) is inserted over the edge of the bale by use of the transition area (90). <IMAGE>
Patent DE-60230728-D1 (DE)
Inventor: HASEGAWA KOICHI
IPC: G11B7/258
Filed: 2002-03-15
Granted: 2009-02-26
Abstract: Provided is a sputtering target material which has a high reflectance and which is excellent in a sulfurization resistance, comprising an Ag alloy prepared by alloying Ag with a specific small amount of the metal component (A) selected from In, Sn and Zn, a specific small amount of the metal component (B) selected from Au, Pd and Pt and, if necessary, a small amount of Cu.
Patent DE-60230987-D1 (DE)
Inventor: MILLER PAUL J
IPC: A61M25/00
Filed: 2002-06-24
Granted: 2009-03-12
Abstract: A catheter is disclosed providing a balloon catheter having a distal tip that is flexible while additionally incorporating high column strength. The present invention additionally provides a distal tip region that accommodates for various sized guidewires. In preferred embodiments, the distal tip region is initially configured for accommodating the passage of 0.12-inch guidewires only. Through specific manufacturing processes, however, the distal tip is modified so that it also may be expanded to accommodate the passage of 0.14-inch guidewires. In additional preferred embodiments, an elastomeric sleeve is disposed over the modified distal tip to allow the tip to return to the initial 0.12 -inch accommodating profile when the larger 0.14-inch guidewire is withdrawn from the catheter.