baber/WOPTO huggingface dataset:
Patent JP-2023536928-A (JP)
Title: 表示デバイスのブランクサブフィールド駆動方法
IPC: G09G3/32
Filed: 2020-08-06
Abstract: 本発明は、フレームごとに各ピクセルを駆動することを含み、表示デバイスの複数のピクセルが行及び列のアレイのアレイで配置され、１つのフレームの周期が１つ以上のデータセクション及び１つ以上のオフセクションを有し、データセクションの時間長さの比が２の累乗列と略同じであるようにし、各データセクションが、指定されたブライトネス、グレースケールカラー、又はルミナンスと関係があるＯＮ又はＯＦＦ周期に対応し、各オフセクションが、指定されたブライトネス、グレースケールカラー、又はルミナンスと無関係であるオフ周期に対応する、表示デバイスの作動方法を提供する。方法は、利用可能なデータ駆動時間を増やす。本発明の適切な応用の１つはマイクロＬＥＤディスプレイである。
Patent JP-2023537364-A (JP)
Title: アプタマーを用いた高機能性人工臓器の製作方法
IPC: C12N5/071
Filed: 2021-07-27
Abstract: 本発明は、アプタマーを用いた灌流可能な血管を含む高機能性人工臓器の製作方法などに関し、本発明のアプタマーを脱細胞保持体のコーティング剤として用いるとき、血管の付着能、生存能および血管形成能などを増進させて、従来の抗体より効率的な脈管構造の再建が可能である。したがって、アプタマーを用いて製作された血管化された人工肝は、生体内で血栓形成が減少するだけでなく、肝機能性を増進させる効果を示すところ、本発明のアプタマーを使用して製作した人工臓器を用いた疾患治療方法としての応用が期待される。【選択図】図５ａ
Patent JP-2023539182-A (JP)
Title: イオン交換に関するシステム及び方法
IPC: G21F9/12
Filed: 2021-08-19
Abstract: 処理流体がイオン交換容器内の複数の点で同時に注入され、汚染物質及び／又は汚染された処理流体がイオン交換媒体全体に均一に分配されることを可能にする、イオン交換のためのシステム及び方法が本明細書において開示される。これらのシステム及び方法は、固定式、可動式、及びモジュール式の実施形態のうちの１つ以上において実装され得る。 
【選択図】図１０
Patent JP-2023536549-A (JP)
Title: プリロードチャンバおよび半導体プロセスプラットフォーム
IPC: H01L21/677
Filed: 2021-09-17
Abstract: 本発明は、プリロードチャンバおよび半導体プロセスプラットフォームを開示する。当該プリロードチャンバは、チャンバ本体と、ウェハ支持フレームとを含む。チャンバ本体には収容キャビティが開設され、ウェハ支持フレームは収容キャビティ内に位置する。ウェハ支持フレームは、鉛直方向に沿って間隔を空けて設けられる、ウェハを搭載するための複数の搭載台と、複数の搭載台と接続される支持フレーム本体と、固定部材とを含む。ここで、複数の搭載台の少なくとも１つは、支持フレーム本体の上方に位置し、且つ固定部材を貫通させることができる回避部が開設される。固定部材は、支持フレーム本体とチャンバ本体とを固定接続させる。上記方案は、ウェハの搬送効率が低いという課題を解決できる。
Patent JP-2023548756-A (JP)
Title: 破裂ダイヤフラムを有する燃料隔離システム
IPC: B64G1/40
Filed: 2020-10-28
Abstract: 燃料隔離システムは、入口から出口へと延在する流路を画定するバルブ本体と、流路内にあり、入口を出口から流体的に密閉する破裂ダイヤフラムと、破裂ダイヤフラムに隣接するように配置されたアクチュエータと、を含む。破裂ダイヤフラムはバルブ本体と一体化される。アクチュエータは、移動して破裂ダイヤフラムを破り、それにより入口と出口とを流体的に接続するように構成されたプランジャを含む。
Patent JP-2023545085-A (JP)
Title: ポリアミド粉体組成物を製造するための収率最適化方法
IPC: C08G69/28
Filed: 2021-10-11
Abstract: 本発明は、ポリアミドをベースとする粉体組成物を、最適化された収率で調製する方法に関する。本方法は、前記組成物と1種又は複数のモノマーとを含む混合物を水の存在下で重縮合することによって、より小さいDv50を有するポリアミドプレポリマーをベースとする組成物をリサイクルする工程を含む。本発明はまた、得られた粉体組成物、及び特に流動層浸漬塗装によって金属基材を塗装するための該組成物の使用に関する。
Patent JP-2023550338-A (JP)
Title: 電極組立体、バッテリー、それを含むバッテリーパック及び自動車
IPC: H01M10/0587
Filed: 2022-01-19
Abstract: 本発明は、電極組立体、バッテリー、それを含むバッテリーパック及び自動車を開示する。電極組立体は、第１電極と第２電極とこれらの間に介在された分離膜とが一つの軸を中心に巻き取られてコア及び外周面を定義する電極組立体であって、前記第１電極は、長辺端部に前記電極組立体の巻取軸方向に沿って前記分離膜の外部に露出した無地部を含み、前記無地部の一部は前記電極組立体の半径方向に折り曲げられて折曲表面領域を形成し、前記折曲表面領域の一部領域は、前記電極組立体の巻取軸方向で前記無地部の積層数が１０以上である。
Patent JP-2023549613-A (JP)
Title: デジタル染色画像を生成するためのイメージング方法およびシステム、人工知能システムを訓練するための訓練方法、ならびに非一時的記憶媒体
IPC: G06T1/00
Filed: 2021-11-19
Abstract: 一態様では、本発明は、生体組織プローブ（５０）の物理的画像（５０’）が同時マルチモーダル顕微鏡法（５３）によって取得される、無染色組織生体組織プローブ（５０）の物理的画像（５０’）から生体組織プローブ（５０）のデジタル染色画像（５１’）を生成するためのイメージング方法に関する。別の態様では、本発明は、そのような方法で使用されるように人工知能システムを訓練するための訓練方法に関する。その上、本発明は、生体組織プローブ（５０）のデジタル染色画像（５１’）を生成するための、および／または人工知能システムを訓練するためのシステムに関する。システムは、上記方法のうちの少なくとも１つを実施するための処理ユニットを備える。さらに、本発明は、コンピュータによって実行されると、コンピュータに上記方法を実施させる命令を含む非一時的記憶媒体に関する。
Patent JP-2023551850-A (JP)
Title: 炭化水素貯留層における炭化水素と水との接触位置を決定するための装置及び方法
IPC: G01V9/00
Filed: 2021-12-21
Abstract: 本発明は、炭化水素貯留層における炭化水素と水との接触位置を決定するための方法（１００）に関し、前記方法は、以下のステップ：・異なる既知のサンプリング深さ値で、接続された炭化水素貯留層から収集された少なくとも２つの貯留層流体サンプルを提供し（１１０）；・前記少なくとも２つの貯留層流体サンプルのそれぞれから、希ガスの少なくとも１つの同位体の存在量を測定し（１２０）；及び・測定された前記存在量及び前記少なくとも２つの貯留層流体サンプルの前記既知のサンプリング深さ値から、前記炭化水素貯留層内の炭化水素と水との接触位置を計算すること（１３０）を含む。
Patent JP-2023542251-A (JP)
Title: 中性子捕捉療法のための中性子ビームの生成、減速および構成のためのデバイス
IPC: A61N5/10
Filed: 2021-08-09
Abstract: 中性子ビームの生成、減速および構成のためのデバイスは、前記陽子ビームが方向付けられる入口開口（１）と、中性子ビームを生成するために陽子ビームが加速される標的（２）と、中性子をエピサーマル範囲のエネルギーにする減速材（３）と、前記減速材（３）を囲む反射性カバー（４）と、濾過ステージ（５）と、前記中性子ビームのための出口開口（６）と、前記出口開口（６）を介して前記デバイスから出射しない中性子およびガンマ線放射を抑制するためのシールド（７）と、を備える。前記濾過ステージ（５）は、高速中性子、熱中性子およびガンマ線放射をそれぞれフィルタリングする少なくとも３層を備える。本発明は、中性子捕捉療法（より具体的にはホウ素療法）において使用される。【選択図】図１
Patent JP-2023552228-A (JP)
Title: ポリイミドプロセスのための水共触媒
IPC: C08G73/10
Filed: 2021-12-09
Abstract: 本開示は、ポリイミドゲルを形成する方法を対象とする。これらの方法は、一般に、ポリアミック酸を形成し、水の存在下でポリアミック酸を脱水剤で脱水することを含む。得られたポリイミドゲルは、ポリイミドまたは炭素のキセロゲルまたはエアロゲルに変換され得る。これらの方法は、急速なまたは瞬間的でさえあるゲル化を提供するのに有利であり、これは、ポリイミドゲルを含むビーズの形成に特に有用であり得る。開示されている方法によって調製されたポリイミドまたは炭素ゲル材料は、例えばリチウムイオンバッテリ内の電極材料として、電気化学的反応を含む環境での使用に好適である。【選択図】なし
Patent JP-2023552480-A (JP)
Title: 不飽和イソオレフィンコポリマーをハロゲン化する方法におけるｋ＋含有酸化剤によるハロゲン回収
IPC: C08F8/18
Filed: 2021-12-10
Abstract: ハロゲン化イソオレフィンコポリマーを製造する方法は、有機溶媒中に溶解させた不飽和イソオレフィンコポリマーを含む不飽和イソオレフィンコポリマーセメントを、ハロゲン化条件下で、ハロゲン化剤、及びカリウム塩系酸化剤の水溶液と接触させて、有機相及び水性相を含む2相の反応媒体を形成させる工程を含み、酸化剤はハロゲン化水素を遊離ハロゲンへ転化することが可能である。この方法は、改善されたハロゲン回収を実現し、水の存在の影響を受けにくく、より安定で環境へのダメージが少ない酸化剤を利用する。
Patent JP-2024503383-A (JP)
Title: 血栓摘出デバイス
IPC: A61B17/22
Filed: 2022-01-11
Abstract: 本発明は、実質的に円筒形の構造体（１）を備えた血栓摘出デバイスであって、円筒形の構造体（１）が、近位端および遠位端を有し、かつ複数のブレースから成る複数のメッシュ（３，４）を備えており、血栓摘出デバイスが、円筒形の構造体（１）の近位端に設けられた近位のメッシュに配置され、近位方向に延びる２つの接続ブレース（５，５’）を備え、かつ円筒形の構造体（１）の近位側に配置された連結部材（１１）が設けられており、該連結部材に接続ブレース（５，５’）が接続されており、連結部材（１１）がプッシャ／挿入ワイヤに接続されており、近位のメッシュのブレース、接続ブレース（５，５’）および連結部材（１１）ならびに近位のメッシュ間に配置され得るテンショニングブレース（９）が、閉じた環構造（６）を形成し、環構造（６）が、環構造（６）の空間的な位置を確認するためのＸ線不透過性の材料を有する環状マーカ（１２）を備えている、血栓摘出デバイスに関する。本発明は、カテーテルからの解放時の血栓摘出デバイスの開放挙動および血管内でのデバイスの配向の可視化を可能にする。
Patent JP-2024500181-A (JP)
Title: 繊維芽細胞活性化タンパク質阻害剤
IPC: C07D401/14
Filed: 2021-12-20
Abstract: 【要約】本開示は、一般式（I）の化合物またはその薬学的に許容される塩、立体異性体または溶媒和物を提供し、ここで、Cはキレート剤ユニットであり、ABはアルブミン結合ユニットであり、FAPIは線維芽細胞活性化タンパク質阻害剤ユニットである。本開示は、さらに上記化合物及び放射性核種のキレート、医薬組成物、及び疾患の診断及び治療のための線維芽細胞活性化タンパク質の阻害剤としてのそれらの用途を提供する。C-AB-FAPI (I)
Patent MX-2007003091-A (MX)
Title: Fast-curing modified siloxane compositions.
Inventor: MOWRER NORMAN R
IPC: C08K5/09
Filed: 2005-09-13
Abstract: Fast-curing modified siloxane compositions comprise; (1) an alkoxy- or silanol-functional silicone intermediate, (2) at least one amine reactive ingredient selected from the group consisting of acetoacetate-functional ingredients, acrylate-functional ingredients, and mixtures thereof, (3) an epoxy-functional ingredient, (4) a curing agent selected from the group consisting of amines, aminosilanes, ketimines, aldimines and mixtures thereof, and (5) water. Other ingredients useful in forming fast-curing modified siloxane compositions of this invention include silanes, organometallic catalysts, solvents, pigments, fillers and modifying agents. The above-identified ingredients are combined and reacted to form a fully cured protective film comprising a cross-linked enamine polysiloxane and/or acrylate polysiloxane chemical structure in a reduced amount of time when compared to conventional epoxy siloxane compositions.
Patent MX-2007005315-A (MX)
Title: Gas odorant.
Inventor: MUELLER URS
IPC: C07C11/30
Filed: 2005-11-08
Abstract: The present invention refers to the use as gas odorant of alkoxy alkynes of formula (I) wherein R1 is methoxy or ethoxy; and R2 is hydrogen or methyl, to a process of odorizing gas and to fuel gas comprising it.
Patent MX-2007006983-A (MX)
Title: Liquid vessel liner and method of application.
Inventor: MORRISON FRANK T
IPC: B05D7/00
Filed: 2007-06-11
Abstract: A liner and method of application for use on a metal surface to protect metal structures such as cooling towers, evaporative condensers, and other liquid containing vessels such as tanks from corrosion, leaks, and wear. The liner is an inexpensive apparatus and process comprising a coated metal having a second sealing and bonding layer and a third protective sealing layer. The liner method comprises applying an organic bonding layer (56) onto the galvanized substrate, and applying an elastomeric barrier coating (26) to the bonding layer. The barrier coating material is applied to preseal the seams between adjoining panels assembled to form the basin. The barrier coating (26) is applied to the entire inside of the basin (10) to form a homogenous barrier coating extending out of the basin.; The liner edge is isolated from the basin by extending the liner to a point between the basin and an upper section. The liner comprises galvanizing layer, a bonding layer on the galvanized metal, and an elastomeric third layer on the bonding layer. The liner further comprises preseals (25) at the seams, corner molds and link holes in the substrate to attach and protect the liners integrity.
Patent MX-2007011113-A (MX)
Title: Compositions containing expandable microspheres and an ionic compound, as well as methods of making and using the same.
Inventor: FABER RICHARD D
IPC: D21H21/54
Filed: 2006-03-13
Abstract: This invention relates to composition containing expandable microspheres and at least one ionic compound and having a zeta potential that is greater than or equal to zero mV at a pH of about 9.0 or less at an ionic strength of from 10"6 M to 0.1M., as well as methods of making and using the composition.
Patent MX-2007013446-A (MX)
Title: Micelle thickening systems for hair colourant and bleaching compositions.
Inventor: GLENN ROBERT WAYNE
IPC: A61K8/14
Filed: 2006-04-25
Abstract: The present invention relates to hair colouring and or hair bleaching compositions comprising at least one oxidizing agent and a specified worm-like micelle phase thickening system. The compositions surprisingly provide improved hair colourant and bleaching compositions which deliver improved lift, lightening and colour delivery whilst minimizing damage which are easy to manufacture and have long shelf life stability.
Patent MX-2007014041-A (MX)
Title: Extrusion process for making compositions with poorly compressible therapeutic compounds.
Inventor: SERAJUDDIN ABU T M
IPC: A61K31/155
Filed: 2006-05-08
Abstract: A process for preparing solid dosage forms that contain poorly compressible therapeutic compound. The process, for example, provides for the inventive use of an extruder, especially a twin screw extruder, to melt granulate a therapeutic compound(s) with a granulation excipient.
Patent MX-2007015349-A (MX)
Title: A method of performing actions related to handover by a mobile station that is in power saving mode in a wireless mobile communication system.
Inventor: KIM BEOM JOON
IPC: H04W52/02
Filed: 2006-03-10
Abstract: A method of performing actions related to handover by a mobile station (MS) in a wireless mobile communication system is disclosed. More specifically, the MS receives information from a base station (BS), wherein the information includes at least one action for performing handover and at least one condition corresponding to the at least one action. Furthermore, the MS transmits a request message to perform the at least one action based on the received information from the BS and receives a response message in response to the request message. Lastly, the MS performs the at least one action according to the received response message.
Patent MX-2008000438-A (MX)
Title: High tryptophan soybean meal.
Inventor: LIANG JIHONG
IPC: A23L11/00
Filed: 2006-07-06
Abstract: The present invention is directed to a soybean meal with high tryptophan content and its method of manufacture. The high tryptophan content soybean meal is to be used as an ingredient in animal feeding operations. Also provided are products from the further processing of the soybean meal.
Patent MX-2008009195-A (MX)
Title: METHOD AND APPARATUS FOR PROVIDlNG TREATMENT CHEMICALS TO PROCESS WATER SYSTEMS.
Inventor: EMERSON JAMES C
IPC: B01J4/04
Filed: 2006-12-13
Abstract: Forward osmosis is utilized to dispense chemicals into a process water system such as a cooling tower, chilled water system, boiler, or pulp and paper plant. The dispenser (10) includes a flexible pouch (14) filled with treatment chemicals (44) and an osmotic membrane (34). The dispenser is placed in the process water system. Water passing through the membrane (34) increases internal pressure, which forces chemical (44) into the process water system. The exposed surface area of the osmotic membrane (34) can be aftered to control dispensing rate. The apparatus can either utilize the chemical treatment agent as the osmotic agent, or can be divided into two separate areas utilizing a separate osmotic agent such as sodium chloride. The dispenser can be positioned in the process water system at a location where water flows onto the osmotic membrane only when the process water system is in operation.
Patent MX-2008009453-A (MX)
Title: Automated tool for human assisted mining and capturing of precise results.
Inventor: JONES SCOTT A
IPC: G06F17/30
Filed: 2007-01-12
Abstract: An automated tool for human assisted analysis of search results for obtaining precise results responsive to a request. A single query entry triggers a search using one or more resources and results returned from the resources are displayed in a corresponding embedded renderer. A human provider analyzes the returned results and extracts pertinent information for delivery to a requestor who submitted the query.
Patent MX-2008012945-A (MX)
Title: Modulators of atp-binding cassette transporters.
Inventor: BEAR BRIAN
IPC: A61P31/00
Filed: 2007-04-09
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Patent MX-2008014552-A (MX)
Title: Triol form of rosuvastatin.
Inventor: NIDDAM-HILDESHEIM VALERIE
IPC: C07D239/42
Filed: 2008-03-13
Abstract: Provided is a rosuvastatin triol and its use as a reference standard for analysisof rosuvastatin. (I).
Patent MX-2008015348-A (MX)
Title: Crystalline forms of 11 ã¿-(4-acetylphenyl)-20,20,21,21,21-pentaf luor-17- hydroxy-19-nor-17î±-pregna-4,9-dien-3-one.
Inventor: BECKMANN WOLFGANG
IPC: A61K31/567
Filed: 2007-05-31
Abstract: The present invention relates to crystalline forms of 11 Ã¿-(4-acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor -17Î±-pregna-4,9-dien-3-one. In particular, the invention relates to two crystalline ansolvate/anhydrate forms of this compound, polymorphs I and II. However, the present invention also relates to crystalline solvates, for example, methanol and ethanol solvates of 11 Ã¿-(4-acetylphenyl)- 20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17Î±-pregna-4,9-die n-3-one, as precursors for the preparation of these two polymorphs I and II. Processes are described for the preparation of polymorph I by means of displacement crystallization or by means of extraction. The choice of the last solvent, before the ansolvate formation can take place, on the basis of the differences in the purification ratios of the individual solvates of 11 Ã¿-(4-acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor -17Î±-pregna-4,9-dien-3-one is described. Polymorph I, according to the invention, is particularly suitable for the preparation of drugs.
Patent MX-2008016450-A (MX)
Title: Recovery of aromatic dicarboxylic acids from waste polyester resin.
Inventor: ALGHATTA HUSSAIN
IPC: C07C51/09
Filed: 2006-06-21
Abstract: The present invention relates to a process of recovering aromatic dicarboxylic acids with low metal contaminants from manufactured articles and/or articles contaminated with PVC or chlorinated compounds, made of or containing aromatic polyester resins, such as beverage bottles, fibers and films, or from waste from processing of these resins. In particular, the invention relates to the recovery of terephthalic acid, isophthalic acid and 2, 6 -naphthalene dicarboxylic acid from bottles for recycling which are made of PET, PEN or aromatic polyester copolymers.
Patent MX-2009005647-A (MX)
Title: Plumbing valve with stick control handle.
Inventor: FLEISCHMANN GARY A
IPC: F16K31/60
Filed: 2007-10-17
Abstract: Faucets (14) are provided with joystick type control handles. The joysticks (34) are provided with springs (38) outside the main valve housing either between the joystick handle and lever stick (32), or between the joystick handle and an associated ball. In the latter case the ball retains a sliding disk.
Patent MX-2009011169-A (MX)
Title: Method and system for sorting and processing recycled materals.
Inventor: VALERIO THOMAS A
IPC: B29B17/02
Filed: 2008-04-18
Abstract: Processing recycled materials to recover plastics, copper wire, and other non-ferrous metals. Aspects of the invention employ density separation to separate plastic-bearing materials from copper-bearing materials. Plastic-bearing materials are further separated to separate light plastics from heavy plastics. Plastics are concentrated, extruded, and palletized. Copper and other valuable metals are recovered from copper-bearing materials using a water separation table.
Patent MX-2010002885-A (MX)
Title: S1p receptor modulating compounds and use thereof.
Inventor: BURLI ROLAND
IPC: A61P3/10
Filed: 2008-09-19
Abstract: The present invention relates to amides that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non- glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
Patent MX-2010004345-A (MX)
Title: Performance dashboard monitoring for the knowledge management system.
Inventor: GRACE DANIEL DOUGLAS
IPC: G11B27/00
Filed: 2010-04-21
Abstract: Embodiments of the present invention provide a method, system, computer program product, or a combination of the foregoing for creating a knowledge management system including a performance dashboard monitoring system that is standardized and centralized across the channels and sub-channels in an organization. The performance dashboard monitoring system is used to track, measure, and resolve incidents that occur throughout the channels, sub-channels, systems, and applications of an organization. The system receives information related to two or more incidents, where each incident is associated with one or more of a business channel, sub-channel, or application. The system stores the information on a memory device. The system tracks the status of at least one incident between the occurrence and the resolution of the incident. The system displays on a user interface the information related to the incident on a channel, sub-channel, application, or individual incident level.
Patent MX-2010009882-A (MX)
Title: Sealed electrical source for air-powered electrostatic atomizing and dispensing device.
Inventor: BALTZ JAMES P
IPC: B05B5/03
Filed: 2009-03-02
Abstract: A coating dispensing device (20) includes a trigger assembly (26) for actuating the coating dispensing device to dispense coating material and a nozzle (30) through which the coating material is dispensed. The coating dispensing device further includes a first port (34) adapted to supply compressed gas to the coating dispensing device and a second port (36) adapted to supply coating material to the coating dispensing device. The coating dispensing device further includes a generator (38) having a shaft (42). A turbine wheel (40) is mounted on the shaft. Compressed gas coupled to the first port impinges upon the turbine wheel to spin the shaft, producing voltage. An electrode (62) adjacent the nozzle is coupled to the generator to receive electricity therefrom to electrostatically charge the coating material. First and second seals seal the shaft where the shaft protrudes from the generator at its ends.
Patent MX-2011000891-A (MX)
Title: Structural variants of antibodies for improved therapeutic characteristics.
Inventor: GOLDENBERG DAVID M
IPC: A61K39/395
Filed: 2009-07-21
Abstract: The present invention provides substituted humanized, chimeric or human anti-CD20 antibodies or antigen binding fragments thereof and bispecific antibodies or fusion proteins comprising the substituted antibodies or antigen binding fragments thereof. The antibodies, fusion proteins or fragments are useful for treatment of B-cell disorders, such as B-cell malignancies and autoimmune diseases, as well as GVHD, organ transplant rejection, and hemolytic anemia and cryoglobulinemia. Amino acid substitutions, particularly substitution of an aspartate residue at Kabat position 101 of CDR3 VH (CDRH3), result in improved therapeutic properties, such as decreased dissociation rates, improved CDC activity, improved apoptosis, improved B-cell depletion and improved therapeutic efficacy at very low dosages. Veltuzumab, a humanized anti-CD20 antibody that incorporates such sequence variations, exhibits improved therapeutic efficacy compared to similar antibodies of different CDRH3 sequence, allowing therapeutic effect at dosages as low as 200 mg or less, more preferably 100 mg or less, more preferably 80 mg or less, more preferably 50 mg or less, most preferably 30 mg or less of naked antibody when administered i.v. or s.c.
Patent MX-2011001549-A (MX)
Title: A crystalline form of 4- (5-{ (ir) -1- [5- (3- chlorophenyl) isoxazol-3-yl] ethoxy } - 4 -methyl- 4h- 1, 2,4- triazol-3-yl) pyridine.
Inventor: AASTROEM HANS
IPC: C07D249/08
Filed: 2009-08-11
Abstract: Thepresent invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy }-4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel crystalline form for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it as well as processes for the preparation of the novel crystalline form.
Patent MX-2011005060-A (MX)
Title: Reinforced polygonal containers and blanks of sheet material for making the same.
Inventor: SMITH KENNETH CHARLES
IPC: B31D5/04
Filed: 2011-05-12
Abstract: A blank of sheet material for forming a polygonal container is provided. The blank includes a bottom panel, two opposing side panels, and two opposing end panels. Each side panel extends from a side edge of the bottom panel, and each end panel extends from an end edge of the bottom panel. Each end panel includes at least one major stacking extension extending from a top edge thereof. The blank further includes a reinforcing panel assembly extending from a first side edge of a first end panel of the two end panels. The reinforcing panel assembly includes an inner end panel having a minor stacking extension extending from a top edge thereof. The minor stacking extension is configured to align with a respective major stacking extension to form a stacking tab.
Patent MX-2011005339-A (MX)
Title: Ladle pipe for liquid metal casting plant.
Inventor: COLLURA MARIANO
IPC: B22D41/50
Filed: 2009-11-19
Abstract: The present invention relates to a ladle pipe (10) for liquid metal casting, that includes a channel (11) for the metal flow extending substantially along an axis, and a metal envelope (17) provided in an end portion of the pipe corresponding to an end of the channel, characterised in that the envelope (17) includes at least one belt (18) having a thickness no lower than 10 mm, preferably 14 mm, and in that the pipe (10) includes means (20) for connection to the driving means, the connection means being provided on the envelope (17) and in particular on the belt (18) thereof.
Patent MX-2011005485-A (MX)
Title: Safening 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide injury on cereal crops.
Inventor: SCHMITZER PAUL
IPC: A01N25/32
Filed: 2009-11-18
Abstract: Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of AD67 (MON 4660), benoxacor, 2-CBSU, daimuron, dichlormid, dicyclonon (BAS 145 138H), fenchlorazole-ethyl, fenclorim, fluxofenim, furilazole (MON 13900), glyphosate, isoxadifen-ethyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil and mixtures thereof.