baber/WOPTO huggingface dataset:
Patent DO-P2015000189-A (DO)
Title: Inhibidores quinazolínicos de formas mutadas activantes del receptor del factor de crecimiento epidérmico
Inventor: LI DAVID YUNZHI
IPC: C07D403/12
Filed: 2015-08-11
Abstract: LA INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA (I) O UNA DE SUS SALES FARMACÉUTICAMENTE ACEPTABLES: (I) QUE POSEEN ACTIVIDAD INHIBITORIA FRENTE A FORMAS MUTADAS ACTIVANTES DE EGFR Y QUE SON, POR CONSIGUIENTE, ÚTILES POR SU ACTIVIDAD CONTRA EL CÁNCER Y EN MÉTODOS DE TRATAMIENTO DEL CUERPO HUMANO O ANIMAL. LA INVENCIÓN TAMBIÉN SE REFIERE A COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y A SU USO EN LA ELABORACIÓN DE MEDICAMENTOS PARA EMPLEAR EN LA PRODUCCIÓN DE UN EFECTO CONTRA EL CÁNCER EN UN ANIMAL DE SANGRE CALIENTE TAL COMO UN SER HUMANO. FORMULA I.
Patent EC-SP10010608-A (EC)
Title: 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas
Inventor: BAUER SHAWN M
IPC: A61K31/506
Filed: 2010-11-15
Abstract: La presente invención está dirigida a compuestos de fórmula I-V y tautómeros correspondientes o sales farmacéuticamente aceptadas, ésteres y profármacos correspondientes que actúan como inhibidores de quinasa syk. La presente invención también está dirigida a intermediarios utilizados en la elaboración de dichos compuestos, la preparación de dichos compuestos, composiciones farmacéuticas que contienen dichos compuestos, métodos para inhibir la activada de quinasa syk, métodos para inhibir la acumulación de plaquetas y métodos para prevenir o tratar una cantidad de enfermedades mediadas al menos parcialmente por actividad de quinasa syk, como enfermedades cardiovasculares, enfermedades inflamatorias, enfermedades autoinmunes y trastornos proliferativos de células. La Fórmula (I) Y1 es seleccionada del grupo que consiste en: (a) y (b), Z es O o S, D1 es seleccionada del grupo que consiste en: (a) fenilo sustituido por un grupo, R5 (b) naftilo (c) C3-8cicloalquilo (d) heteroarilo (e) heterociclolo.
Patent EC-SP11011057-A (EC)
Title: Ácidos naftilacéticos
Inventor: HE YUN
IPC: A61K31/185
Filed: 2011-05-16
Abstract: La invención se refiere a compuestos de la fórmula I:y a sales y ésteres farmacéuticamente aceptables de los mismos, en el que W, X, Y y R1-R7 tienen los significados definidos en la descripción detallada y en las reivindicaciones. Además, la presente invención se refiere a métodos de obtención y uso de los compuestos de la fórmula I así como a composiciones farmacéuticas que contienen tales compuestos. Los compuestos de la fórmula I son antagonistas o agonistas parciales del receptor CRTH2 y pueden ser útiles para tratar enfermedades y trastornos asociados con este receptor, por ejemplo el asma.
Patent GB-189700041-A (GB)
Title: Improvements in Winding Up Devices for Musical Boxes, Orchestrals, and the like Instruments.
Filed: 1897-01-01
Granted: 1897-03-20
Abstract: 41. Roepke, C. A., and Roepke & Co. Jan. 1. Spring motors; weight motors.-Winding-mechanism for the springs or weights of musical boxes, orchestrals, &c., consists of a wheel or plate d secured to the side of the box or case by a ring e. The wheel is held friction-tight between plates f, attached either directly to the winding- spindle a, or, as shown, to a sleeve b connected therewith. The wheel d slips between the plates f if an attempt is made to overwind or to turn in the wrong direction.
Patent GB-189708395-A (GB)
Title: Improvements in Valve Gear for Motive Power Engines.
Inventor: EDWARDS EDMUND
Filed: 1897-04-01
Granted: 1897-09-25
Abstract: 8395. Edwards, E., [Richter, C.]. April 1. Valves and valve gear.-Engines provided with rotary distributing-valves are reversed by means of clutches, as described below. In the arrangement shown in Fig. 1, the valve spindle a is rotated through bevel gearing and a clutch f, g. To reverse the engine, the half-clutch g is lowered by means of a handle i and is automatically raised by a cam l on a spindle ratchet by wheels n, o. In the modified arrangement shown in Fig. 5, the reversing is done automatically after being started by hand. By means of a spindle i<4> the groove in the half-clutch g is put in engagement with the fixed roller q. The clutch is thus disengaged and after rotating through 180‹ is put in gear again.
Patent GB-189709156-A (GB)
Title: Improvements in Stoppers for Bottles and Jars.
Inventor: HARRAWAY JAMES
Filed: 1897-07-24
Granted: 1898-02-26
Abstract: 9156. Harraway, J., and Scutt, A. July 24. Stoppers.-The stopper consists of a metal cap ST having an internal packing-disc of cork, and formed or provided with lugs L adapted to pass down the vertical grooves G in the neck of the bottle &c. The neck is also formed with horizontal or downwardly-inclined grooves HG, into which the lugs are entered, by rotating the stopper, to lock the latter in position. The rotary movement of the stopper is limited by the stops S. Instead of forming the neck with grooves HG, it may be formed with a projecting shoulder, beneath which the lugs L engage.
Patent GB-189712973-A (GB)
Title: Improvements in Musical Instruments.
Inventor: MORGAN JAMES
Filed: 1897-05-25
Granted: 1897-10-30
Abstract: 12,973. Lake, H. H., [Morgan, J.]. May 25. Automatic instruments.- Relates to means for automatically playing keyboard instruments- The stickers 23 can be operated either by the keys 2 or pneumatics 4. Their lower ends have brackets 22 sliding on rods 19, by which they are connected to the pneumatics, but on which they can slide without actuating the latter when the instrument is played manually. The pneumatics are arranged i n four staggered rows, and are connected by ports 5 with chambers 9 which can be put into communication with a vacuum chamber 7 or with a chamber 11, open to the air, by valves 18. Each pair of valves 18 is connected by a spindle 17 to a diaphragm 16 which closes the end of one of the ports 13 in the tracker-board 15. The trackerboard acts as usual in conjunction with a tunesheet on rollers 28, 29, the former of which is the take-up roll. The roller 28 is operated by toothed gearing, and is mounted on a pivoted carriage 28<1>. When it is desired to re-wind the tune-sheet on the roller 29, the carriage 28<1> is tilted by moving a stop. This disconnects the toothed gearing, and also throws into operation a clutch which actuates the roller 29, by belt gearing. The motor actuating the rolls is connected with them through coned pulleys, thus enabling the speed of the tune-sheet to be regulated. The bellows are situated below the keyboard, and exhaust the air from a common channel which is opened to the air when the tunesheet is being re-wound. The channel has also in connection with it an equalizing-bellows, and the vacuum can be controlled by a valve operated by a stop 84.
Patent GB-189714276-A (GB)
Title: A New or Improved Lining for Hats, Shoes, and other Garments.
Inventor: PACKER WILLIW
Filed: 1897-06-11
Granted: 1897-07-17
Abstract: 14,276. Packer, W. June 11. Linings ; ventilating. - A ventilating-lining is made, as shown in elevation in Fig. 1 and in plan in Fig. 2, by applying strips of material 2 to a sheet of material 1 so as to leave air passages 3. Fig. 3 shows in plan the same result obtained by folding the fabric, and several methods of folding the fabric so as to obtain ribs on one or both sides of it are described.
Patent GB-189722167-A (GB)
Title: Improvements in and relating to Closets or Privies.
Inventor: O'BRIEN DANIEL
Filed: 1897-09-28
Granted: 1898-03-26
Abstract: 22,167. O'Brien, D. Sept. 28. Dry closets.-Fig. 3 shows a cross-section of a range of closets suitable for a school. Under each seat there is a pan A<7>, having a perforated bottom on which rests a layer of charcoal, cinders, or other filtering - material, through which liquid percolates. As shown in Fig. 8, each pan has a liquid receptacle A<8> and conducting-tube A<9>. The liquid from the several pans flows into a trough C', from which pipes C' convey it to a pit C containing dry ashes. The ashes may be mixed with a deodorizing and disinfecting material. Behind the partition A<3> is a bar B, mounted in bearings in the end walls, and having at one side an operating- lever B', which is preferably boxed in. This bar supports a series of hoppers containing dry absorbent material, preferably that described below. At intervals these hoppers are swung backwards by the lever B' and allowed to fall, so that each strikes the back of the seat and throws a portion of its contents into the corresponding pan. The space A<2> allows access to the pit C and to the hoppers and pans, and affords accommodation for the drying and making up of the absorbent materials. Fig. 8 shows a single closet in which the pan is carried on bars over the pit C. In this case the hopper is operated by a chain D<2>. In a modification, the hopper may be connected to a movable seat so that the closet is automatic. The urine may be received in a removable vessel, placed below the pan, and a stove may be provided in which the closet paper may be burned in place of being mixed with the soil. A deodorizing and disinfecting compound for use in these closets may be made by mixing together half a ton of dry night-soil, eighteen hundredweight of ashes, five pounds of ground charcoal, a pound and a half of permanganate of potash, one pound of gypsum, and two and a half pounds of alum. Half an ounce of izal in a quart of boiling water is sprinkled over the ashes. When night-soil from the closets described above is used the proportions of the added materials may be very considerably reduced.
Patent GB-189724847-A (GB)
Title: An Improved Lifeboat.
Inventor: YOUNGHUSBAND LANCELOT
Filed: 1897-10-26
Granted: 1897-12-04
Abstract: 24,847. Younghusband, L., and Younghusband, S. S. Oct. 26. Drawings to Specification. Masts.-A lifeboat is provided with a telescopic mast pivoted to the hull so that, when not in use it can lie in the bottom of the boat.
Patent GB-189726064-A (GB)
Title: Improvements in Incandescence Gas Burners.
Inventor: IMRAY JOHN
Filed: 1897-11-09
Granted: 1898-09-10
Abstract: 26,064. Imray, J., [Kern, O.]. Nov. 9. Incandescent gas lamps. - A burner tube B, of the type described in Specification No. 294, A.D. 1897, is surmounted by conical or other tubes A, C of about the relative proportions shown in Fig. 1. Heat is conducted by a serrated disc D and a boss E to the perforated tube C,which thus serves both to mix and heat the air and gas currents ascending from the tube B.
Patent GB-189726166-A (GB)
Title: Improvements in or connected with Match Vesta Boxes and the like.
Inventor: POSTLETHWAITE WILLIAM EDWARD
Filed: 1897-11-10
Granted: 1897-12-18
Abstract: 26,166. Postlethwaite, W. E. Nov. 10. Match and like boxes.-A match box or the like provided with an igniting-appliance and a wind guard is shown in an open position in Fig. 2. A case a for containing the matches is hinged at c to a metal plate which is free to slide within an outer case d which serves as a wind guard. An igniting- appliance, preferably consisting of a short tube or U-shaped piece c having a serrated tongue p, is pivoted to one side of the case d. When in use, the igniting-appliance is turned into the position shown in Fig. 2, and a cigar &c. passed through an aperture in the bottom of case d is ignited by means of a match passed through the tube or piece e. In a modified form, the igniting-appliance lies within a recessed part of the outer case, when not in use.
Patent GB-189726329-A (GB)
Title: An Apparatus for Blotting or Drying Writing.
Inventor: MILLS BENJAMIN JOSEPH BARNARD
Filed: 1897-11-11
Granted: 1897-12-18
Abstract: 26,329. Mills, B. J. B., [Moulard, E., and Gueny, J.]. Nov. 11. Blotting-appliances; penholders. - Fig. 4 shows a perspective view of the appliance, with the roll of blotting-paper removed. The frame D is attached to the top of a penholder. An endless roll of blotting- paper is passed over the rollers A, B, the links G, G<1> are then turned into the same plane as the link L, and the hinged arm E is turned into place and held by a spring clip when the appliance is ready for use.
Patent GB-189730055-A (GB)
Title: Improvements in and relating to Gear Cases for Cycles.
Inventor: GARDINER CHARLES
IPC: B62J13/04
Filed: 1897-12-20
Granted: 1898-10-29
Abstract: 30,055. Gardiner, C., and Lamont, N. Dec. 20. Gear cases.-Relates to gear cases with separable parts made to allow exposure of the crankaxle chain-wheel and to give access to the chain. Fig. 1 shows the complete case. The body 35 is fixed to the machine by clips 36, 37, and is formed with two tubes through which the chain passes. The end 25, which is separate and fixed in place by a clip 27 and screw 28, carries one half of the chainwheel cover. The other half consists of a semicircular piece 29 connected to the body 35 by tongues and grooves, and can be removed by rotating it round the crank axle after detachment of the end 25. Removable pieces 31, Figs. 1, 2, and 3, allow access to the chain, these pieces being held in place by tongues 32 and slides 33. The end 38 is removable and of ordinary construction. The case may be fixed in place after removal of the chain and back stay. In a modification, the back of the case extends to the curved end, the piece 25 being cut away behind, but this arrangement necessitates the removal of the crank and chain-wheel before it can be fixed in place.
Patent GB-189730239-A (GB)
Title: Improved Manufacture of Seamless Garments.
Inventor: BOULT ALFRED JULIUS
Filed: 1897-12-21
Granted: 1898-04-16
Abstract: 30,239. Boult, A. J., [Pugliese, J.]. Dec. 21. Coats and jackets; trousers; waistcoats; seamless garments.-The body of the garment is produced upon a knitting-machine, the arms, collar, and the like are afterwards knitted on to the body, which is then treated with boiling water, after which it is dipped in glue,.and dried on a wooden bust or former of the shape and dimensions required. Brilliancy and elasticity are imparted to the garment by rubbing it with a wood or leather buffer. Coats, trousers, waistcoats, and other garments may be manufactured in this way.
Patent GB-189800213-A (GB)
Title: An Oiling System for Engines and the like.
Inventor: ENGMAN CHARLES FREDRIK
Filed: 1898-01-04
Granted: 1898-02-05
Abstract: 213. Engman, C. F. Jan. 4. Drawings to Specification. Lubricating a complete plant, such as a steam engine and dynamo. Oil is pumped through pipes to the various parts requiring lubrication, and the overflow from these parts returns to the oil reservoir. Insulating-sections may be placed in the delivery and return pipes.
Patent GB-189803189-A (GB)
Title: Improvements in the Construction of Handle-bars for Bicycles.
Inventor: JENSEN PETER
Filed: 1898-02-08
Granted: 1898-04-02
Abstract: 3189. Jensen, P., [Claus Handle Bar Co.]. Feb. 8. Handle-bars for bicycles are adjustably secured to their stems. In the form shown in Fig. 1, a sleeve B, secured to the centre of the handle-bars A, is screw-threaded at one end and has a bevelled corrugated portion b<1> at the other. This sleeve B is placed inside a socket C formed on the handlebar stem D, and is secured therein by a nut E having a bevelled face as shown. The corrugated portion of the sleeve B engages a similarly corrugated part of the socket C and prevents the rotation of the bars. To adjust the bars the nut E is released and the bars slid out of engagement with the socket. In a modification shown in Fig. 3, the bar A is expanded, screw-threaded, and corrqgated like in sleeve B, and the bar A' secured inside it as shown.
Patent GB-189803690-A (GB)
Title: An Improved Method of and Means for Drying Wood and other Vegetable Substances.
Inventor: MCPHAIL HUGH
Filed: 1898-02-14
Granted: 1898-04-16
Abstract: 3690. McPhail, H. Feb. 14. Drying wood, roots, fruit, &c.-Wood, roots, fruit, and other vegetable substances are dried by being subjected to the direct action of superheated steam. The materials are placed on a suitable trolley C, which is then run through the opening A' upon the rails c in the cylindrical steam-jacketed drying- chamber A. Superheated steam is fed by a pipe B' to a series of pipes B, which are open at their ends or perforated and are situated beneath a perforated floor b. Shelves a may be provided at the sides of the chamber. Steam is withdrawn by way of the opening D by a suitable exhaust fan or pump. A cover A<2>, for the opening A', is provided.
Patent GB-189804261-A (GB)
Title: Improvements in Metallic Packing.
Inventor: MANSFELDT CHARLES ANDREW REINH
Filed: 1898-02-21
Granted: 1898-04-09
Abstract: 4261. Maasfeldt, C. A. R. Feb. 21. Stuffing-boxes.-The packing is contained in a casing D furnished with a soft metal packing-ring d<1> abutting against the neck bush a and pressed home by a ring C or gland B. The packing consists of soft metal segmental rings P which are pressed into contact with the rod by the action of rings R, R<1> forming the end of the casing. These rings are made to accommodate springs between them, and have lips which prevent them from being pushed out of place thereby when the casing is removed from the stuffing-box. All the parts except the rings P may be divided into two parts connected by screws to facilitate putting them in position on the rod. The rings P are made in three or more sections, separately cast, and the ends are faced with Muntz or other hard metal to prevent them from adhering together.
Patent GB-189805821-A (GB)
Title: Improvements in Inside and Outside Window Blinds and Shades.
Inventor: ADAMS JOHN FRANCIS
Filed: 1898-03-09
Granted: 1898-10-15
Abstract: 5821. Adams, J. r. and Iorns, C. R. March 9. Window blinds.- Relates to improvements in the blinds described in Specification No. 16,523, A.D. 1896. The slats c are connected by interweaving them with the cords b, Fig. 1. Notches a, Fig. 2, are made in the edges of the slats to prevent them from slipping endways. The edges of the slats may be bevelled as shown at d, Fig. 3, to prevent light from passing between them. Paper, xylonite, and other materials may be used for making the slats, in place of wood.
Patent GB-189806510-A (GB)
Title: Improvements in Thrashing Machines.
Inventor: DORLIN CHARLES WILLIAM
Filed: 1898-03-17
Granted: 1899-03-15
Abstract: 6510. Dorlin, C. W. March 17. Thrashing-machines.-Rilates to means whereby a thrashing-machine may be adapted to thrash clover as well as corn. Fig. 1 shows the machine adapted for treating clover. The cobs are separated in the drum A and fall from the shakers B upon the series of sieves C, D, E, E', E<2>. The cobs are winnowed by a blast from the mouth e of a fan N on the drum shaft. Plantain seeds are separated by the screen E<2>, and discharged by a spout J<1>. The cobs pass from the screen E<2> by an elevator G to a clover drum H, and thence to a series of screens and a winnowing-device which clean the seeds and discharge them in two qualities from the machine.
Patent GB-189819251-A (GB)
Title: Improvements in or connected with Brick Making Machines.
Inventor: ORMROD WILLIAM
Filed: 1898-09-09
Granted: 1899-07-15
Abstract: 19,251. Ormrod, W., and Wild, J. W. Sept. 9. Moulding bricks.-In order to avoid the handling of the soft bricks, the stream of clay D from the pug-mill or extrusion machine is forced by a pushboard C through the cutting-wires or knives B on to a shelf E, and from the shelf on to the smooth table G of a truck F. The table is on the same level as the shelf, and is stayed by a detachable rod or otherwise.
Patent GB-189901024-A (GB)
Title: Improvements in Dynamometrical Apparatus.
Inventor: BOURON HENRI
Filed: 1899-01-16
Granted: 1899-05-13
Abstract: 1024. Bouron, H. Jan. 16. D y n a m o m e t e rs.-The springs ordinarily employed between the driving and driven parts are replaced by hydraulic apparatus connected to a manometer. In the form shown, which may be variously modified, the connection is made by bolts a in guided slides b pressing on diaphragms R and communicating pressure, through liquid below and in the tubes T,to a registering-manometer M. The resistance to the slight turning movement of the parts relatively to each other is reduced by rollers g.
Patent GB-189903156-A (GB)
Title: Improvements in Roller Bearings.
Inventor: PILKINGTON FRANCIS ANGELO
Filed: 1899-02-13
Granted: 1899-07-01
Abstract: 3156. Pilkington, F. A. Nov. 12, A.D. 1898, [date applied for under Sec. 103 of Patents &c. Act, A.D. 1883]. Roller bearings for shafts. The rollers care held in place by a cage consisting of end rings a<1> connected by parallel bars. A neck c<1> is formed at one end of each roller, and this neck is passed through an opening in the ring d. Split rings e are placed around the rollers, and the parts are then inserted in the split sleeve g, which is placed in the bearing-boss f. The interior of the boss.f and the exterior of the sleeve g are tapered so that adjustment can be affected by the rings g<2>, g<3>. The pin j prevents the sleeve g from turning, and the rings e are prevented by pins from turning in the sleeve. The ring d is retained in place by the screwed ring g'.
Patent GB-189905861-A (GB)
Title: Improvements in Rotary Engines.
Inventor: CUMMINGS HORACE STUART
Filed: 1899-03-17
Granted: 1899-04-29
Abstract: 5861. Cummings, H. S. March 17. Revolving-cylinder type.-A shaft 7, arranged eccentrically to a shaft 5 and to a flywheel 10, has motion transmitted to it from the latter. The hollow shaft 5, which embraces a longitudinallyadjustable stationary hollow shaft 19, carries a cylinder.11 engaging guides 30 in the wheel 10 to lugs 32 on which the piston-rods 31<a> are attached. The entrance and exit of steam or air to the cylinder is controlled by a conical valve 12 carried by the shaft 19, which can be turned to start, stop, or reverse the engine, and having inlet ports 16, 20 and outlet ports 21, 17, Fig. 2. The cylinder and pistons are shaped as shown in Fig. 3, to minimize the volume of the ports 13 and 14. The apparatus is enclosed in a casing 2, Fig. 1, whereby the exhaust steam is imprisoned and made to lubricate the parts ; this casing may have an outlet for the condensed steam and a small outlet for the slow escape of steam. Antifriction rollers 35, engaging guides 34 and carried by a crosshead 36, may be used to transmit motion to the shaft 7.
Patent GB-189906776-A (GB)
Title: Reversible Busk Protector for Corsets.
Inventor: YOUNG ROBERT LINDSAY
Filed: 1899-03-29
Granted: 1900-02-24
Abstract: 6776. Young, R. L. March 29. Corsets.-A busk protector consists of a band a, Fig. 2, of fabric on which are fixed two metal sockets b and a cross band c. The sockets b and band c serve to hold in place a strip of steel d, Fig. 3. The protector is to be stitched on the inside at the lefthand side of the corset, so that the steel comes immediately behind the front busk.