baber/WOPTO huggingface dataset:
Patent EP-1012139-A1 (EP)
Inventor: SETTI EDUARDO L
IPC: A61K31/545
Filed: 1998-08-28
Abstract: L'invention concerne des dérivés de l'acide 2-oxo-1-azétidine-sulfonique qui sont de puissants inhibiteurs des β-lactamases bactériennes, notamment des β-lactamases de la classe C; ainsi que des compositions pharmaceutiques contenant lesdits composés et éventuellement une bêtalactamine. Ces composés et ces compositions peuvent être utilisés pour inhiber l'inactivation des β-lactamases et traiter les infections bactériennes.
Patent EP-1023278-A1 (EP)
Inventor: ZHANG WEIJIANG
IPC: C07D241/24
Filed: 1998-10-08
Abstract: The present invention relates to novel intermediate, processes, and novel pyrazine compounds which are ultimately useful in the preparation of chemicals and pharmaceuticals.
Patent EP-1027336-A1 (EP)
Inventor: PETERS DAN
IPC: C07D417/14
Filed: 1998-10-27
Abstract: Heteroaryl diazacycloalkane derivatives (I) are new. Heteroaryl diazacycloalkane derivatives of formula (I) and their enantiomers or mixtures, isotopes and salts are new. [Image] n : 1-3 m : 0-2; R : H, alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; R 1>aminophenyl; nitrophenyl; hydroxyphenyl; alkoxyphenyl; monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino, NO 2, COOR 3, CONR 2R 3, NHCO 2R 2and/or OCONR 2R 3); aryl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X-alkyl-Y-alkyl (optionally alkyl substituted by alkoxy or thioalkoxy); X-(alkyl) o-aryl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylene-dioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X-(alkyl) o-Z (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2), monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2) (sic), bicyclic heterocyclyl comprising a 5-6 membered monocyclic heterocyclyl fused to a benzene ring (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, alkoxy-alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino, NO 2, aryl optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amine and/or NO 2) or monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X, Y : O, S or NH, N-alkyl or Se; o : 0 or 1 and Z : 5-6 membered monocyclic heterocyclyl. ACTIVITY : Analgesic; Neuroprotective; Nootropic; Tranquilizer; Antiinflammatory; Antiaddictive; Antismoking; Anticonvulsant; Neuroleptic; Antidepressant; Antiasthmatic; Antianginal; Antimigraine. The affinity of 1-(6-chloro-5-methoxy-3-pyridyl)-homopiperazine fumaric acid salt for nicotinic Ach receptors was investigated in a test for in vitroinhibition of 3H-cytisine binding. The compound exhibited and IC 50value of 0.0007 mu M. MECHANISM OF ACTION : Nicotinic acetyl choline receptor ligand.
Patent EP-1038852-A1 (EP)
Inventor: YANG DENING
IPC: B28B1/00
Filed: 1998-11-12
Abstract: The disclosed marble-like ceramic sheet material
has many colored silicate regions composed of silicate
materials on the surface. In at least part of said colored
silicate mass regions, there is a bleeding region whose
color differs from those of the said colored silicate mass.
Also, there is a transition region formed between said
adjacent colored silicate mass. The invention relates to a
method for manufacturing the ceramic sheet material.
Patent EP-1026953-A1 (EP)
Inventor: KOBUSSEN JOS
IPC: A22C7/00
Filed: 1998-10-28
Abstract: An extrusion attachment (10) for sausage making machines have three concentric tubes (12, 42, 54) with the inner tube defining a first passageway (60), the space between the inner (12) and intermediate (42) tubes comprising a second passageway (62), and the space between the outer tube (54) and the intermediate tube (42) defining a third (83) passageway. The diameter of the inner tube (12) is small so that meat emulsion (70A and 70B) passing into the inner tube (12) is subjected to a higher pressure than that of the pressure in the second passageway (62). The lower pressure meat material in the second passageway (62) is thinly coated on the strand of the high pressure meat material extruded from the inner tube (12). A thin layer of collagen material (72) is extruded from the third passageway (83) for deposit on the outer surface of the meat layer extruded from the second passageway (62). An alternate extrusion attachment (84) has only two concentric tubes as defined above with an elongated hollow casing on the outer surface of the two tubes adapted to receive a coextruded strand of sausage.
Patent EP-1070378-A1 (EP)
Inventor: HUTCHINSON JOHN EDWARD
IPC: H02K7/18
Filed: 1998-12-15
Abstract: L'invention concerne un générateur d'électricité comprenant une source de puissance mécanique, un générateur mû par ladite source de puissance mécanique de manière qu'il fournisse un courant électrique pour une charge; le système comprend aussi un circuit pour imposer un cycle de travail variable à la charge ou des moyens de fixation d'une batterie. Ainsi, lorsque l'ensemble fonctionne, la batterie montée agit comme un tampon contre l'excès de courant généré par ledit générateur, la batterie étant conçue pour envoyer du courant à une charge lorsque le générateur commence à délivrer un courant à une valeur plus basse que celle préétablie.
Patent EP-1041929-A1 (EP)
Inventor: VAMMEN KLAUS
IPC: A61B8/08
Filed: 1998-12-22
Abstract: L'invention concerne un procédé pour étudier les propriétés mécaniques des os chez un sujet animal ou humain vivant. Ce procédé consiste à lancer une onde d'impulsion ultrasonore dans le corps du sujet concerné et à tracer une courbe correspondant à la grandeur de l'onde ultrasonore réfléchie par rapport au temps écoulé depuis le lancement de cette onde. Il est possible d'identifier dans cette courbe un intervalle dans lequel la grandeur de l'onde d'impulsion ultrasonore réfléchie présente une pente constante par rapport au temps. Le procédé selon l'invention consiste ensuite à calculer l'atténuation de l'onde ultrasonore en fonction des valeurs enregistrées sur la courbe dans cet intervalle.
Patent EP-1038070-A1 (EP)
Inventor: FERTIG GUENTER
IPC: F15B1/02
Filed: 1998-11-21
Abstract: Die Erfindung geht aus von einer hydraulischen Steueranordnung für eine mobile Arbeitsmaschine, insbesondere für einen Radlader, die zur Dämpfung von Nickschwingungen dient, mit mindestens einem Hydrozylinder (12), mit dessen Hilfe ein Arbeitswerkzeug bewegbar ist, mit einem Wegeventil (11) zur Steuerung der Druckmittelwege zwischen einem Druckraum (15) des Hydrozylinders (12), einer Druckmittelquelle und einem Tank (27), mit einem Hydrospeicher (21), der über ein Füllventil (22; 71), das sich in einer Füllleitung (20) befindet, mit der Druckmittelquelle verbindbar ist und dessen Ladedruck über das Füllventil (22; 71) bis auf einen Grenzdruck erhöhbar ist und der zur Dämpfung von Nickschwingungen mit dem Druckraum (15) des Hydrozylinders (12) verbindbar ist, und mit einem Sperrventil (22; 75), das bei Vorliegen einer ersten Bedingung in eine Durchgangsstellung bringbar ist, in der es von Druckmittel in Richtung vom Hydrospeicher (21) zu dem Druckraum (15) des Hydrozylinders (12) und umgekehrt durchströmbar ist. Erfindungsgemäss ist das Sperrventil (22; 75) auch bei Vorliegen der ersten Bedingung dann in seine Sperrstellung bringbar, wenn der Lastdruck in dem Druckraum (15) des Hydrozylinders (12) oder der Speicherdruck einen Maximaldruck erreicht.
Patent EP-1037920-A1 (EP)
Inventor: TOFTGAARD RUNE
IPC: A61K38/00
Filed: 1998-12-18
Abstract: Protéines, polypeptides et nucléotides apparentés à l'homologue humain du suppresseur de la drosophile du gène fusionné, qui est impliqué dans la transduction de signaux dans la voie HH-PTC. La présente invention concerne également des anticorps contre les polypeptides selon la présente invention. Les molécules selon la présente invention sont utiles dans des méthodes diagnostiques et thérapeutiques concernant des états pathologiques associés à des défauts dans ladite voie, en particulier le cancer et certaines malformations. D'autres champs d'application des molécules selon la présente invention sont par ex. les études portant sur le développement embryonnaire, la transcription génique et la cicatrisation.
Patent EP-0963754-A1 (EP)
Inventor: STAEB FRANZ DR
IPC: A61K8/67
Filed: 1999-02-11
Abstract: Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen,und mindestens einem kosmetisch oder pharmazeutisch unbedenklichen Retinoid.
Patent EP-0936161-A1 (EP)
Inventor: BUECHI ROBERT
IPC: B65G19/02
Filed: 1999-02-09
Abstract: The pulley is positioned along a pre-set path. The body (5) is connected by means of a coupling to the pulley (1). The coupling consists of two parts; the first part is positioned on the pulley , and the second part (6) has at least one body. The two deformable coupling parts are aligned parallel with the path being traveled. The at least one body is guided by means of guides (2). The two coupling parts are pressed together and joined, and pulled apart for release.
Patent EP-0939471-A1 (EP)
Inventor: UENOHARA HIROYUKI
IPC: H01S5/183
Filed: 1999-02-24
Abstract: A vertical-cavity surface-emitting
semiconductor laser has a substrate (1), a lower DBR
structure portion (2) having a plurality of layers
provided on the substrate (1), a semiconductor
buried structure portion (10) provided over the
lower DBR structure portion (2) having at least one
layer with buried therein an active layer (6), and
an upper DBR structure portion (11) having a
plurality of layers provided over the semiconductor
buried structure portion (10) comprising the active
layer. The active layer (6), at least one layer
arranged over the active layer (6) and at least one
layer arranged beneath the active layer (6)
constitute an optical resonator region and each of
the layers constituting the optical resonator region
has an effective refractive index higher than
respective effective refractive indices of other
layers in the upper and lower DBR structure portions
(2, 11) and a refractive index of the at least one
layer constituting the semiconductor buried
structure portion (10).
Patent EP-0953768-A1 (EP)
Inventor: SCHWUCHOW DIETMAR
IPC: F04C2/08
Filed: 1999-03-18
Abstract: The drive mechanism comprises two or more intermeshing gearwheels (10,12), which mesh with a two-flank contact. The gearwheels have on their non torque-transferring flanks (30,32), a grooved recess for hydraulically coupling two successive toothed chambers (26), which can be set in staggered planes. The recesses have a constant cross-section in the expansion direction, while the gearwheel machine can be formed as an internal or external gearwheel machine.
Patent EP-0952033-A1 (EP)
Inventor: MEYER THOMAS
IPC: B60N2/42
Filed: 1999-04-01
Abstract: The seat has a backrest and head support attached to the backrest by a connecting device. A linearly movable adjuster on the backrest has a rocker element (42) on which the connecting element is guided so that displacement of the adjuster (28) transverse to the seat causes displacement of the head support in the seat's longitudinal direction. The adjuster is connected to a pyrotechnical drive element on the back rest for its displacement. The drive element is connected to an acceleration sensor (62) by which it is activated.
Patent EP-0935308-A1 (EP)
Inventor: MATSUBARA HIROSHI
IPC: H01Q1/12
Filed: 1994-04-12
Abstract: The invention provides a direction adjustment indicator for a satellite radio wave receiving
antenna (1) comprising a demodulating circuit (20i) adapted to demodulate a satellite radio
wave received by said antenna (1), a peak holding circuit (21i) adapted to hold a peak
value of the demodulated output of said demodulating circuit (20i) and always to output the
held peak value, a comparator circuit (22i) adapted to receive said held peak value and
said demodulated output as two inputs thereof, said comparator circuit (22i) being further
adapted to give an output signal when said inputs are equal and to give another different
output signal when said inputs are not equal, a display element (23i) adapted to give two
different kinds of display in accordance with said output signals, a reset means (51)
provided in said peak holding circuit (21i), said reset means (51) being adapted to reset
said held peak value when said demodulated output does not reach said held peak value in
a predetermined time interval, a triggering means (53) adapted to give said reset means
(51) a triggering pulse and being connected to said peak holding circuit (21i), a first A/D
converter (54) being connected to said demodulating circuit (20i) and to said triggering
means (53), and adapted to judge, through the variation of said demodulated output,
whether the antenna (1) is moved or not, a second A/D converter (55) being connected to
said comparator circuit (22i) and to said triggering means (53), and adapted to find the
operation of said display element (23i) through the output of said comparator circuit (22i),
wherein said reset means (51) is triggered by said triggering means (53) and said held peak
value is thereby reset when said antenna is moved for a predetermined time interval but
said display element (23i) does not give any display useful for determining the desirable
receiving direction of said antenna (1).
Patent EP-0983989-A1 (EP)
Inventor: HELMLINGER DANIEL DR
IPC: A61Q13/00
Filed: 1999-08-19
Abstract: Methyl-substituted cyclotetradec-5-en-1-one derivatives (I) are new.   Cyclotetradec-5-en-1-one derivatives of formula (I) and their Z and E isomers are new: R1, R2 = H or Me, one being H and the other Me. An Independent claim is also included for a perfume composition containing at least one compound (I).
Patent EP-1092404-A1 (EP)
Inventor: BEHERE HANS-JUERGEN
IPC: A61M27/00
Filed: 1999-10-11
Abstract: The wound dressing has a ring-shaped adhesive section (10) with an open inner zone covered by a shrouding (13), hermetically sealed at the circumference (14) with the adhesive section (10). The open section of the dressing is covered (15) to keep the zone (19) sterile over the wound. The shrouding (13) has a gas inlet (17) with a closure, to fill the shrouding (13) with a gas. The shrouding (13) is evacuated by a gas outlet (18) with a closure. The gas is ozone to kill germs or a gas containing nitrogen to prevent the growth of germs.
Patent EP-1048811-A1 (EP)
Inventor: TOMASCHEK GERD
IPC: E05B63/18
Filed: 1999-09-24
Abstract: Foot operated door opening device for opening a hinged
door, comprising a foot pedal, pivotally connected to
mounting means and an actuator rod, rigidly connected to
the foot pedal. The actuator rod is mounted parallel to a
swingable edge of the door, and contacts in operation a
catching pin, mounted onto and protruding from the door.
Patent EP-0958863-A1 (EP)
Inventor: SATAKE SATORU
IPC: B02C9/04
Filed: 1999-04-14
Abstract: A flour milling method and a flour milling system are provided,
in which a plurality of milling steps (4,5, 6,7,
8,9) whose milling degrees are different from one another
are performed sequentially from an upperstream to a downstream,
each of the milling steps including a breaking
step (4,6,8) and a grading step (5,7,9). The steps are
carried out by sorting (3;18) the raw wheat grains into
regular wheat grains and material other than the regular
wheat grains, forwarding (90) the sorted regular wheat
grains to the uppermost-stream milling step, and forwarding
(13) the sorted material other than the regular wheat
grains to at least one of downstream milling steps at a
downstream of the uppermost-stream milling step. The
method and the system enable the production of wheat flour
of better quality with better yield than that conventionally
produced.
Patent EP-1055990-A1 (EP)
Inventor: PROUDLER GRAEME
IPC: G06F11/34
Filed: 1999-05-28
Abstract: There is disclosed a computer entity having a trusted component which
compiles an event log for events occurring on a computer platform. The event log
contains event data of types which are pre-specified by a user by inputting details
through a dialogue display generated by the trusted component. Items which can
be monitored include data files, applications drivers and the like. The trusted
component operates through a monitoring agent which may be launched onto the
computer platform. The monitoring agent may be periodically interrogated to
make sure that it is operating correctly and responding to interrogations by the
trusted component.
Patent EP-0994102-A1 (EP)
Inventor: LANGLOIS MICHEL
IPC: C07D333/58
Filed: 1999-10-12
Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR<1>; R<1> = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR<1>aC(Q)R<2>a, -NR<1>aC(Q)NR<2>aR<3>a or -C(Q)NR<1>aR<2>a; R<1>a-R<3>a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).
Patent EP-0942095-A1 (EP)
Inventor: FERRARA GIOVANNI
IPC: D06F77/00
Filed: 1999-03-10
Abstract: Ironing equipment including a support hinged to the ironing board
(19) having, at the other end, a hook holding the iron (11) so as to
infer it rotatory and translatory movements. Such support includes a
device that allows the lifting of the iron from the board.
Patent EP-1047443-A1 (EP)
Inventor: CHARETTE MARC F
IPC: A61K48/00
Filed: 1999-01-21
Abstract: L'invention concerne des procédés et des compositions qui sont destinés à protéger la fonction cognitive chez un mammifère, notamment chez l'humain, souffrant d'une lésion du tissu cérébral par l'administration d'un morphogène ou d'un acide nucléique codant pour un morphogène. Les procédés et compositions de l'invention peuvent être utilisés pour contrer les troubles de mémoire et/ou pour produire un effet neuroprotecteur chez les sujets courant le risque de troubles de mémoire résultant d'un traumatisme mécanique ou chimique, de neuropathies, de maladies neurdégénératives ou de carence d'oxygène ou de glucose.
Patent EP-1051316-A1 (EP)
Inventor: HAUPT KARLHEINZ
IPC: B60T13/52
Filed: 1999-01-26
Abstract: Es wird eine Bremskraftübersetzungsvorrichtung insbesondere für Kraftfahrzeuge vorgeschlagen, welche Mittel (10) zum Sensieren oder Erkennen des Aussteuerungspunkts (4) der Bremskraftübersetzungsvorrichtung aufweist, wobei mit dem Mittel (10) ein den Aussteuerungspunkt (4) meldendes Signal generierbar ist. Die Erfindung erlaubt die Herstellung leistungsfähiger Bremskraftübersetzungsvorrichtungen, welche wenig Bauraum beanspruchen und erschliesst insgesamt neue Einsparpotentiale.
Patent EP-0996314-A1 (EP)
Inventor: QIAN YIFAN
IPC: H05B33/10
Filed: 1999-02-24
Abstract: A substrate for an organic electroluminescence
display element comprises a support (11), a plurality
of first electrode lines (12) arranged apart from each
other on the support (11), and a plurality of partition
walls (13) arranged apart from each other and extending
in a direction to cross the first electrode lines (12).
Each of the partition walls (13) has eaves in an upper
portion and flared side surfaces in a lower portion.
Patent EP-1064508-A1 (EP)
Inventor: ITOH MASAKI
IPC: F25D23/06
Filed: 1999-02-24
Abstract: A storage container (13) for use in a refrigerator includes an open-topped box (14) having a top opening oriented upwardly and a forward opening (AO) oriented in a direction perpendicular to a plane of the top opening and communicated with the top opening. A movable hatch (17) is mounted on the box (14) for movement between lifted and lowered positions. This movable hatch (17) when in the lifted position closes the forward opening (AO) of the box (14).
Patent EP-1054924-A1 (EP)
Inventor: THIELEN ALAIN
IPC: C08L23/06
Filed: 1999-02-11
Abstract: A conductive polymer blend comprising:(a) at least two polymers which are at least partially immiscible with each other, and are present in proportions such that each polymer forms a respective continuous phase and the two respective continuous polymer phases are co-continuous with each other in the polymer blend; and(b) at least one conductive material in particulate or fiber form which is substantially localized in one of said co-continuous polymer phases or substantially localized at a continuous interface between said co-continuous polymer phases. Optionally, the polymer blend may contain a mineral filler and/or a thixotropic thickening agent.
Patent EP-1060267-A1 (EP)
Inventor: MATTSON THOMAS L
IPC: C12Q1/68
Filed: 1999-03-03
Abstract: L'invention porte sur un procédé de détection, sélection et clonage d'agents dégradant l'ADN ou entraînant sa dégradation. Ledit procédé utilise des réplicons extra-chromosomaux dont la réplication dépend de la dégradation de l'ADN d'une cellule hôte, pour détecter par criblage des agents entraînant la dégradation de l'ADN de la cellule. L'invention porte également sur un agent entraînant la dégradation de l'ADN de la cellule hôte et permettant la réplication des réplicons, ce qui signale la présence d'agents entraînant la dégradation de l'ADN de la cellule et permet d'isoler et d'amplifier de tels agents.