Patent GB-795222-A (GB)
Title: Improvements in or relating to perspiration-inhibiting compositions, and new compounds for use therein
IPC: C07F5/06
Filed: 1956-04-23
Abstract: The invention comprises the new alkoxy aluminium chlorides of general formula Alx(RO)yClz in which R is an alkyl radical having from 1 to 18 carbon atoms, x is 1 or 2, y is 1, 2 or 5, z is 1 or 2 and 3x=y+z. They may be prepared by reacting anhydrous aluminium chloride, in solution in a lower alcohol, such as ethanol, with an appropriate number of molecular proportions of an aluminium alcoholate.  The new compounds may be obtained by crystallization from the solution or distillation of the alcohol.  In the examples, aluminium diisopropyloxy-chloride is prepared by adding aluminium chloride to ethyl alcohol, treating the resulting solution with aluminium isopropylate and heating the mixture; the ethyl alcohol is distilled off and aluminium diisopropyloxychloride is left; penta-ethoxy dialuminium chloride, penta-isopropyloxy dialuminium chloride, di-hexadecyloxy aluminium chloride, and di-n-butyloxy aluminium chloride are obtained by analogous methods.  Other new alkoxy aluminium chlorides referred to are ethoxy aluminium dichloride, di-methoxy aluminium chloride, n-propoxy aluminium dichloride, isopropoxy aluminium dichloride, penta-isobutoxy dialuminium chloride, dihexyloxy aluminium chloride, decyloxy aluminium dichloride, di-dodecyloxy aluminium chloride and octadecyloxy aluminium dichloride.ALSO:Alkoxy aluminium chlorides, of general formula AIx(RO)yClz in which R is an alkyl radical having from 1 to 18 carbon atoms, x is 1 or 2, y is 1, 2 or 5, z is 1 or 2 and 3x = y + z, are used in the formation of antiperspirant and/or astringent compositions.  They may be used with an inert liquid or solid diluent or carrier compatible with human skin.  The diluents or carriers may be, for example, one or more of the following: monohydric alcohols, polyhydric alcohols, oils, fats, waxes, ointment bases, fluoro chloro hydrocarbons containing alcohols and pulverulent materials suitable as powder bases.  Suitable alcohols for use as carriers are ethyl alcohol, isopropyl alcohol, butyl alcohol, glycerol, 1.3-butylene glycol, 1.2-propylene glycol, sorbitol, diethylene glycol, octyl alcohol, dodecyl alcohol, oleyl alcohol and cetyl alcohol.  The compositions may contain, in addition to one or more alcohols, a non-alcoholic inert organic solvent compatible with the human skin, e.g. carbon tetrachloride, fluoro trichloro methane, difluoro dichloromethane and tetrafluoro dichloro ethane.  The compositions may also contain one or more of the following: bactericidal, fungicidal, skin cleansing and skin protecting agents, ethereal oils, perfumes, cosmetics and aerosol propellant gases.  In the examples anti-perspirants and/or astringent compositions are made of the following constituents: (a) penta-ethoxy di-aluminium chloride, 1.2-propylene glycol, oleyl alcohol, perfume and 2.21-methylene-bis-(3.4.6-trichlorophenol) as a solution in isopropyl alcohol; other humectants, e.g. glycerol or sorbitol, may be used instead of 1.2-propylene glycol, the oleyl alcohol may be replaced by other monohydric alcohols containing from 1 to 18 carbon atoms, and other compatible disinfecting and bactericidal agents may be used instead of 2.21-methylene-bis-(3.4.6-trichlorophenol); (b) penta - isopropyloxydialuminium chloride, 1.3-butylene glycol, a mixture of C10-C18 monohydric alcohols, difluoro-dichloro-methane, 1.2 - tetrafluoro - dichloroethane and perfume in the form of an aerosol spray; (c) di-hexadecyloxy aluminium chloride, oleyl alcohol, sorbitol, perfume and wool fat to give an ointment; (d) di-isopropyloxy aluminium chloride, wheat starch, tragacanth, ethanol, bactericide and sorbitol in a glycerol solution; (e) di-n-butyloxy aluminium chloride, wool fat, cetyl alcohol, aluminium stearate, talc, perfume, 2.21-methylene bis-(3.4.6-trichlorophenol) and silicic acid to give a powder; and (f) penta-ethoxy di-aluminium chloride, a disinfectant, ethereal oil, glycerol and ethanol.