baber/WOPTO huggingface dataset:
Patent EA-015302-B1 (EA)
Title: INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17α-ACETOXY-11β-[4-(N,N-DIMETHYL-AMINO)- PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS
Inventor: DANCSI LAJOSNE
IPC: C07J41/00
Filed: 2007-05-18
Abstract: The present invention relates to a new industrial process for the synthesis of solvate- free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17α-ethynyl-17β-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11), 20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17α-hydroxy-19-norpregna-5(10),9(11); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17α-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17α-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5α,10α- and 5β,10β-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran in the presence of copper (I) chloride catalyst without separation of the isomers by known method, viii) the obtained 3,3,20,20-bis(ethylene-dioxy)-5α,17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl]-19-norpregn-9(11)-ene of formula (III) is reacted with potassium hydrogensulfate in water by known method, ix) the obtained 11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregn-4,9-diene-3,20-dione of formula (II) is acetylated with acetic anhydride in the presence of perchloric acid by known method, finally x) the solvate-free compound of formula (I) is liberated from the obtained solvate containing compound of formula (I) in a 1:1 mixture of ethanol and water at 70°C.
Patent EA-020067-B1 (EA)
Title: Polymorph form iiiof n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide and method for preparation thereof
Inventor: MOHAMAD NESRIN
IPC: A61K31/404
Filed: 2009-03-05
Abstract: The present invention relates to a novel polymorph form III of Sunitinib and a method for its preparation.
Patent EA-019139-B1 (EA)
Title: Bubbling tower hydrocarbon reactor and method of detecting slurry surface level
Inventor: ONISHI YASUHIRO
IPC: B01J8/22
Filed: 2008-09-26
Abstract: A bubbling tower hydrocarbon reactor in which a hydrocarbon compound is synthesized by the chemical reaction of synthesis gas, which comprises hydrogen and carbon monoxide as main components, with a slurry obtained by suspending solid catalyst particles in a liquid. The bubbling tower hydrocarbon reactor comprises: a reactor main body which holds the slurry therein; a synthesis-gas supply unit which supplies the synthesis gas to the slurry; a pressure sensor which has been disposed above the surface of the slurry and measures the pressure of the synthesis gas above the liquid surface; other pressure sensors, which have been disposed below the surface of the slurry and measure the pressure of the slurry; and a level detector which detects the position of the surface of the slurry based on the results of measurements with the pressure sensors. The other pressure sensors have been disposed apart from each other in the axis direction for the reactor main body.
Patent EA-018000-B1 (EA)
Title: Peptidomimetics with glucagon antagonistic and glp-1 agonistic activities
Inventor: BAHEKAR RAJESH H
IPC: A61K38/26
Filed: 2008-12-10
Abstract: The present invention provides novel peptidomimetics, of formula (I), which primarily act as glucose dependent insulin secretagogues. Furthermore, it was found that these peptidomimetics showed glucagon receptor antagonistic activity, along with the GLP-I receptor agonistic activity.
Patent EA-022880-B1 (EA)
Title: Methods of treatment employing prolonged continuous infusion of belinostat
Inventor: SEHESTED MAXWELL
IPC: A61P35/00
Filed: 2009-03-06
Abstract: The present invention relates to a method of treatment of a disease or disorder in a patient being a human, comprising administering a therapeutically-effective amount of (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)acrylamide (Belinostat™) or a salt, hydrate, or solvate thereof, to said patient by prolonged continuous intravenous infusion, said continuous intravenous infusion being for a period of at least about 12 hours; and wherein said disease or disorder is leukemia. Also provided is the use of (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)acrylamide or a salt, hydrate, or solvate thereof in the method of treatment of a disease or disorder in a patient being a human by prolonged continuous intravenous infusion, said continuous intravenous infusion being for a period of at least about 12 hours; and wherein said disease or disorder is leukemia.
Patent EA-017844-B1 (EA)
Title: Storage method
Inventor: MITADERA JUN
IPC: B65D1/00
Filed: 2010-02-17
Abstract: A storage method for storing a package containing content, under irradiation of light. At least a part of a package is formed by polyamide (A) which is obtained by polycondensation of a diamine component containing at least 70 mol% of meta-xylylenediamine, and a dicarboxylic component containing at least 70 mol% of a,?-straight-chain aliphatic dicarboxylic acid having 4 to 20 carbons. When the light is irradiated to the package comprising the polyamide (A), oxygen permeability is decreased, and deterioration of the content can be suppressed.
Patent EA-023084-B1 (EA)
Title: Automatic injection device with delay mechanism including dual functioning biasing member
Inventor: ADAMS MATTHEW ROBERT
IPC: A61M5/20
Filed: 2011-02-24
Abstract: Provided is an automatic injection apparatus including a delay mechanism for properly delivering medication prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle for the syringe, a follower, a locking member, a damping compound between the follower and a supporting surface to dampen rotation of the follower relative to the shuttle, and a dual functioning biasing member acting between the shuttle and the follower. When the locking member moves to a release position during an injection, the dual functioning biasing member first provides a torsional force to force the follower to rotate relative to the shuttle from a latching position to an unlatching position, and then the dual functioning biasing member provides an axial force to force the shuttle axially relative to the follower to move the shuttle for retracting the syringe needle into the housing of the apparatus after injection.
Patent EA-022495-B1 (EA)
Title: A process for removing nitrous oxide from a gas stream
Inventor: ANGELIDES CHRISTOS ODYSSEA
IPC: B01D53/56
Filed: 2011-01-24
Abstract: A process for the removal of nitrous oxide from a gas stream having a contaminating concentration of nitrous oxide to provide a gas stream with a significantly reduced concentration of nitrous oxide is described. The process includes the use of a process system having multiple NO decomposition reactors each of which contain a nitrous oxide decomposition catalyst and heat transfer units each of which contain a heat sink media that are operatively connected in a particular order and arrangement for use in the process. The gas stream is passed to the process system that is operated for a period of time in a specific operating mode followed by the stopping of such operation and reversal of the process flow. These steps may be repeatedly taken in order to provide for an enhanced energy recovery efficiency for a given nitrous oxide destruction removal efficiency.
Patent EA-025001-B1 (EA)
Title: Method of operating a laundry treatment appliance and laundry treatment appliance
Inventor: SCHNEIDER THOMAS
IPC: D06F58/48
Filed: 2011-06-14
Abstract: Laundry treatment appliance (1), such as a drying and/or washing machine which is arranged to perform at least one laundry treatment program, to determine a duration of a power interruption (S2), wherein the duration is divided into a short duration equal to or shorter than a predetermined threshold value and a long duration greater than the predetermined threshold value, and to adapt, after the power interruption, a laundry treatment program, which has run during the power interruption, to the duration of the power interruption (S6), and to continue it (S7). A method is used for operation of the laundry treatment appliance (1), wherein according to the method a duration of the power interruption is determined (S2), and after the power interruption a laundry treatment program, which has run during the power interruption, is adapted to the duration of the power interruption (S6), wherein the laundry treatment program is differently adapted depending on a short and log duration of the power interruption and/or a kind of a laundry treatment phase running during the power interruption and the adapted laundry treatment program is continued (S7).
Patent EA-023359-B1 (EA)
Title: Wood preservative compositions useful for treating copper-tolerant fungi
Inventor: MARS CRAIG ANDREW
IPC: B27K3/52
Filed: 2011-06-21
Abstract: The present invention provides a method of protecting wood or other celiulosic material from decay by copper-tolerant fungi, and wood preservative formulations for use in the same. The wood preservative formulations comprise a biocidal metal compound, a 1,2,4-triazole and a didecyl quaternary ammonium cation. Didecyldimethyl quaternary ammonium compounds are particularly preferred.
Patent EA-023326-B1 (EA)
Title: Compositions containing identical polyamine salts of mixed anionic pesticides
Inventor: HIXSON ADAM
IPC: A01N57/20
Filed: 2011-11-02
Abstract: The present invention relates to a herbicidal composition comprising: a) a first salt, which contains a first anionic pesticide (A1) and a cationic polyamine (B), and b) a second salt, which contains a second anionic pesticide (A2) and a cationic polyamine (B), wherein the first and the second anionic pesticides are selected from dicamba, quinclorac, glyphosate, (2,4-dichlorophenoxy)acetic acid (2,4-D), aminopyralid and (RS)-2-(4-chloro-2-methylphenoxy)propanoic acid (MCPP), and wherein both salts contain the same cationic polyamine (B), and wherein the cationic polyamine comprises at least two amino groups, and wherein the cationic polyamine (B) is a compound of formula (B1)wherein R, R, R, Rand Rare independently H or C-C-alkyl optionally substituted with OH, Rand Rare independently C-C-alkylene, X is OH or NRR, and n is from 1 to 20. The invention further relates to a method for preparing said composition comprising the step of contacting the first salt and the second salt. In addition, the invention relates to a method of controlling undesired vegetation, which comprises allowing a herbicidal effective amount of said composition to act on plants, their habitat or on seed of said plants. Finally, the invention relates to seed comprising said composition. Finally, the invention relates to seed treated by said composition.
Patent EA-028575-B1 (EA)
Title: Consortium of mesophilic and moderately thermophilic chemolithotrophic bacteria for tank leaching of refractory sulphide-containing ores
Inventor: RAMANKULOV ERLAN MIRKHAJDAROVICH
IPC: C22B3/18
Filed: 2014-04-08
Abstract: The invention relates to microbiology and biotechnology and can be used in biohydrometallurgy to extract gold and/or other metals from refractory sulphide ores. The object of the invention is to obtain a consortium of mesophilic and moderately thermophilic chemolithotrophic microorganisms oxidizing sulphide minerals. The problem is solved by isolating strains of mesophilic and moderately thermophilic microorganisms dominating in the ore deposits of Akmola and East Kazakhstan regions with high arsenic content and creation of a consortium of chemolithotrophic microorganisms deposited at KazNIIPPP LLP. Mesophilic microorganisms are represented by strains of Acidithiobacillus thiooxidans B-501, Acidithiobacillus ferrooxidans B-502 and Acidithiobacillus ferrooxidans B-508. A moderately thermophilic microorganism is represented by the strain Sulfobacillus thermosulfidooxidans B-511.
Patent EA-029850-B1 (EA)
Title: Use of isoxadifen-ethyl or isoxadifen for improving plant yield
Inventor: HACKER ERWIN
IPC: A01N47/24
Filed: 2012-09-14
Abstract: The claimed invention is directed to the use of a compound (A) in combination with (i) fluoxastrobin and prothioconazole, (ii) pyraclostrobin and metconazole, (ii i) trifloxystrobin and propiconazole, (iv) trifloxystrobin and prothioconazole, (v) prothioconazole and tebuconazole, (vi) bixafen and prothioconazole, (vii) bixafen and tebuconazole, or (viii) bixafen and trifloxystrobin for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, which plants are growing in their normal habitat, wherein the compound (A) is isoxadifen-ethyl or isoxadifen (acid). Furthermore, the invention is directed to a method for increasing the yield of useful plants or crop plants and to plant yield increasing compositions.
Patent EA-030447-B1 (EA)
Title: Composition comprising at least two influenza a virus-neutralizing-binding molecules
Inventor: HONG SEUNG SUH
IPC: A61K39/395
Filed: 2014-03-28
Abstract: The present invention provides a composition which comprises at least two influenza A virus-neutralizing-binding molecules binding an epitope within a stem region of a hemagglutinin (HA) protein of an influenza A virus, wherein the composition comprises: i) a first binding molecule which can neutralize at least one influenza A virus subtype which is selected from the group consisting of H1, H2, H5 and H9; ii) a second binding molecule which can neutralize at least one influenza A virus subtype which is selected from the group consisting of H1, H3, H5, H7 and H9. The mixed composition of the present invention can effectively neutralize both multiple influenza subtypes of phylogeny groups 1 and 2, and can be used jointly with chemical compounds. Thus said composition of the present invention is very effective in preventing and treating a disease caused by an influenza virus.
Patent EA-030002-B1 (EA)
Title: Wellbore apparatus and method for sand control using gravel reserve
Inventor: YEH CHARLES S
IPC: E21B43/04
Filed: 2013-09-18
Abstract: A method for completing a wellbore in a subsurface formation includes providing a sand screen assembly representing one or more joints of sand screen, joint assembly, and packer assembly. The packer assembly has at least one mechanically-set packer with at least one alternate flow channel. The sand screen assembly and joint assembly also each have transport conduits for carrying gravel slurry, and packing conduits for delivering gravel slurry. The method also includes running the sand screen assembly, connected joint assembly and packer assembly into the wellbore, and setting a sealing element of the packer assembly into engagement with the surrounding wellbore. Thereafter, the method includes injecting gravel slurry into the wellbore to form a gravel pack such that a reserve of gravel packing material is placed above the sand screen assembly. A wellbore completion apparatus is also provided that allows for placement of the gravel reserve.
Patent EA-030392-B1 (EA)
Title: Method for converting a high-boiling hydrocarbon feedstock into lighter boiling hydrocarbon products
Inventor: WARD ANDREW MARK
IPC: C10G65/12
Filed: 2014-06-30
Abstract: The present invention relates to a process for converting a high-boiling hydrocarbon feedstock into lighter boiling hydrocarbon products, said lighter boiling hydrocarbon products being suitable as a feedstock for petrochemicals processes, said converting process comprising the following steps: feeding a hydrocarbon feedstock having a boiling point of >350°C to a cascade of hydrocracking unit(s), feeding the bottom stream of a hydrocracking unit as a feedstock for a subsequent hydrocracking unit, wherein the process conditions in each hydrocracking unit(s) are different from each other, in which the hydrocracking conditions from the first to the subsequent hydrocracking unit(s) increase from least severe to most severe, and processing the lighter boiling hydrocarbon products from each hydrocracking unit(s) as a feedstock for one or more petrochemicals processes.
Patent EA-031866-B1 (EA)
Inventor: TAKAHASHI TAISUKE
IPC: C07D417/14
Filed: 2015-06-05
Abstract: Изобретение относится к соединению формулы (I) или его фармацевтически приемлемой соли, к фармацевтической композиции, содержащей его, а также к применению указанного соединения или его соли для изготовления фармацевтической композиции и для профилактики или лечения заболеваний мочевого пузыря/мочевыводящих путей, связанных с сокращениями мочевого пузыря через посредство мускаринового рецептора М. Изобретение также относится к способу профилактики или лечения заболеваний мочевого пузыря/мочевыводящих путей, связанных с сокращениями мочевого пузыря через посредство мускаринового рецептора М, включающему введение субъекту эффективного количества вышеуказанного соединения формулы (I) или его фармацевтически приемлемой соли:
Patent EA-036001-B1 (EA)
Title: Combination of erlotinib and glutaminase inhibitor for treating lung cancer
Inventor: STEGGERDA SUSANNE M
IPC: A61P37/00
Filed: 2015-06-12
Abstract: The invention relates to a method of treating or preventing cancer, comprising conjointly administering a glutaminase inhibitor and erlotinib, wherein cancer is lung cancer and the glutaminase inhibitor is a compound of formula Iaor a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition for treating lung cancer, comprising a glutaminase inhibitor and erlotinib, wherein the glutaminase inhibitor is a compound of formula Ia. The invention provides the improved treatment of lung cancer.
Patent EA-034597-B1 (EA)
Title: Method of gravitational enrichment of minerals in static aquatic environment
Inventor: ZHELYABOVSKY YURY GRIGORIEVICH
IPC: B03B5/42
Filed: 2017-12-28
Abstract: A method to separate minerals in a static aqueous medium is proposed. Pulp or its components separately: water and a mixture of minerals, is fed into a vessel. Due to different vertical speeds, depending on the density of particles, minerals are dispersed in water. Denser particles precipitate lower, those less dense remain above. Then the vessel is rotated so that the vertical motion vectors of the particles intersect with the side wall of the vessel. As a result, minerals will settle on this wall, fixing the order of separation according to their densities. The practical implementation of the method involves the use a rotating drum, whose inner cavity is divided into separate, non-communicating vessels.
Patent EA-038904-B1 (EA)
Title: Fiber reinforced polypropylene composite
Inventor: LUMMERSTORFER THOMAS
Filed: 2017-06-27
Abstract: The invention relates to a new composite comprising cellulose-based fiber and polymer-based fiber as well as to molded articles made from said composite.
Patent ES-2167204-B1 (ES)
Title: Machos termicamente aislantes y/o exotermicos para la fabricacion de piezas de fundicion.
Inventor: ZUBIZARRETA ISASMENDI JOSE
IPC: B22C1/08
Filed: 2000-01-27
Granted: 2003-05-16
Abstract: El objeto de la invención es una formulación, así como un procedimiento de fabricación, de un macho para moldeo en fundición que tiene características térmicas tales que permiten prescindir del manguito aislante y/o exotérmico. Estos machos son térmicamente aislantes y/o exotérmicos y su formulación incluye una mezcla de arena y material aislante y/o exotérmico en forma de microesferas, estando comprendido el porcentaje de material aislante y/o exotérmico en la mezcla entre un 25% y un 75% en volumen, y un ligante.
Patent ES-2197783-B1 (ES)
Title: Dispositivo para el filtrado de armonicos de intensidad de secuencia cero en redes polifasicas.
Inventor: FAURIA JORDA JOAN
IPC: H01F27/34
Filed: 2001-12-17
Granted: 2004-11-16
Abstract: Dispositivo para el filtrado de armónicos de intensidad de secuencia cero en redes polifásicas. Está conectado en paralelo a una carga (2), y comprende bobinados (12, 13, 14) interconectados de modo que, cuando las corrientes de carga de las distintas fases (9, 10, 11) están equilibradas, los flujos magnéticos generados por cada una de las intensidades de secuencia cero de cada fase (9, 10, 11) se anulan para presentar una impedancia muy baja. Se caracteriza por el hecho de que los bobinados (12, 13, 14) están calculados y conexionados de modo que, ante un desequilibrio en las corrientes de carga, los flujos magnéticos generados sean sensiblemente iguales, manteniéndose sensiblemente inalterado el filtrado de armónicos de secuencia cero. Se consigue un dispositivo para el filtrado de armónicos de intensidad de secuencia cero muy eficaz ante desequilibrados en la carga.
Patent ES-2246621-B1 (ES)
Title: Sistema de explotacion hidroelectrica de un pozo minero.
Inventor: SUAREZ FERNANDEZ SEVERINO
IPC: F03B13/06
Filed: 2003-01-23
Granted: 2007-06-01
Abstract: El sistema de explotación hidroeléctrica de un pozo minero, pretende aprovechar la altura de la caña del pozo de una instalación minera y utilizarla como salto de agua, para la generación de energía eléctrica. El agua, estaría almacenada en la cámara de carga, en el exterior de la mina, cerca de la boca del pozo. De este depósito parte una tubería hacia el interior de la mina con dirección a la turbina. Esta tubería, conduce el agua desde la cámara de carga hasta la turbina. La energía generada es aprovechada haciendo girar solidariamente, con el eje de la turbina, un generador eléctrico que será el encargado de producir la energía eléctrica. Una vez consumado el proceso de generación, el agua está almacenada en la caldera del pozo y por medio de bombas es restituida a la cámara de carga completando así todo el proceso.
Patent ES-2244271-B1 (ES)
Title: Dispositivo retenedor a ventosa.
Inventor: ENET PHILIPPE
IPC: E05C17/04
Filed: 2003-02-03
Granted: 2006-10-01
Abstract: Dispositivo retenedor a ventosa. La invención se refiere a un dispositivo retenedor, para una estructura que tiene al menos un cerramiento, estando destinado el dispositivo retenedor (20) a mantener el cerramiento en una posición de apertura predeterminada, del tipo que comprende un dispositivo de fijación (30) al cerramiento, un dispositivo de fijación (40) a una segunda parte de dicha estructura, y una barra de ajuste (50) unida al dispositivo de fijación (40) a dicha segunda parte de la estructura y comprendiendo un dispositivo de enganche (51) de la barra (50) sobre el dispositivo de fijación (30) al cerramiento. Según la invención, el dispositivo de fijación (30) al cerramiento comprende una ventosa de fijación (31) al cerramiento.