baber/WOPTO huggingface dataset:
Patent EP-4172141-A1 (EP)
Title: Methods for the preparation of linker payload constructs
Inventor: VERKADE JORGE MERIJN MATHIEU
IPC: C07C307/04
Filed: 2021-06-28
Abstract: The present invention concerns a method for the preparation of an alkyne-linker-payload construct of structure Q-L-C (O)-NR 3 -D (1), comprising reacting (i) an alkyne compound of structure Q-L- C(O)-X (2), wherein Q is an alkyne moiety selected from the group consisting of terminal alkyne and (hetero)cycloalkyne; L is a linker, and X is a leaving group selected from halogen, SR 1 , O-succinimidyl, O-(hetero)aryl(R 2 ) 1-5 , wherein R 1  is selected from C 1  - C 6  alkyl and (hetero)aryl; and R 2  is C 1  - C 6  alkyl, halogen or NO 2 ; with (ii) a molecule of structure D-NHR 3  (3), wherein D is a payload, and R 3  is selected from hydrogen, optionally substituted C 1  - C 24  alkyl, optionally substituted aryl. The activated ester derivatives (2) are highly stable and provide for smooth and high-yielding attachment to a cytotoxic payload. The invention further concerns a method for preparing bioconjugates and alkyne compound of structure Q-L-C (O)-X (2).
Patent EP-4172304-A1 (EP)
Inventor: SELVARAJ SHIVAKUMAR
IPC: C12M1/36
Filed: 2021-06-24
Abstract: Système de biotraitement (100, 200) comprenant une unité de stockage (102, 202) pour stocker un fluide d'alimentation (103, 203), un filtre (106, 206) couplé à l'unité de stockage (102, 202) via un chemin d'alimentation (104, 204), et une pompe d'alimentation (114, 212) couplée au chemin d'alimentation (104, 204). Le système de biotraitement (100, 200) comprend en outre une unité de collecte (102, 216) couplée au filtre (106, 206) via un chemin en aval (118, 218) et un capteur de turbidité (134, 224) couplé au chemin en aval (118, 218). En outre, le système de biotraitement (100, 200) comprend une unité de traitement (136, 226) configurée pour recevoir une sortie du capteur de turbidité (134, 224) et déterminer une concentration d'un produit dans un fluide de filtration (121, 222) sur la base de la sortie. L'unité de traitement (136, 226) est en outre configurée pour surveiller un état de fonctionnement du filtre (106, 206) en ligne sur la base de la concentration du produit.
Patent EP-4144002-A1 (EP)
Inventor: TARTAN CHLOE
IPC: H04L/
Filed: 2021-07-05
Abstract: A computer-implemented method of transmitting blockchain transactions to a blockchain network, wherein the method is performed by a first party (402a) and comprises: transmitting at least part of a blockchain transaction to an internet server (401) via an internet service hosted by the internet server, wherein the internet server (401) is configured to connect to one or more nodes of the blockchain network (106), and to transmit a blockchain transaction to the one or more blockchain nodes, wherein the transmitted blockchain transaction comprises the at least part of the blockchain transaction.
Patent EP-4196341-A1 (EP)
Inventor: DAGON FLORENT
IPC: B65H19/26
Filed: 2021-07-26
Abstract: The invention relates to a winding and cutting device (100) that controls the winding and cutting of sheets of rubber products with respect to a winding reel (102) and a product reel (104) that are rotatable with respect to the device (100). The invention also relates to a winding and cutting installation (10) that forms part of a tire manufacturing facility and that includes at least one winding and cutting device (100) of the invention. The invention further includes a winding and cutting process carried out by the installation (10) of the invention.
Patent EP-4182562-A1 (EP)
Title: Compensation assemblies for fluid handling devices and related devices, systems, and methods
Inventor: BALCONI DAVIDE
IPC: F04D1/06
Filed: 2021-07-03
Abstract: Pumps and fluid-handling devices for modifying at least one property of a fluid and related method comprise a compensation assembly including at least one biasing element to enable a hydraulic insert to move within a housing.
Patent EP-4189230-A1 (EP)
Inventor: VERMES-GABOS ANDRAS
IPC: F03B17/06
Filed: 2021-07-27
Abstract: L'invention concerne un ensemble de centrale électrique marine qui comprend un récipient flottant et une unité de fonctionnement de centrale fixée à un navire de flottabilité de telle sorte que ladite unité de fonctionnement puisse au moins être partiellement immergée pendant le fonctionnement. Au moins un élément de liaison assure une liaison articulée entre l'unité d'actionnement et le navire de flottabilité, ce qui permet le mouvement de l'unité de fonctionnement depuis sa position de fonctionnement submergée jusqu'au-dessus du niveau d'eau et adjacent au navire de flottabilité à l'aide dudit élément de liaison tournant dans une position sensiblement parallèle au navire de flottabilité.
Patent EP-4210880-A1 (EP)
Title: Système d'élimination de scories de bancs de travail
Inventor: DURANTI SIMONE
IPC: B08B1/00
Filed: 2021-08-16
Abstract: La présente invention concerne un système d'élimination de scories de bancs de travail comprenant des plaques (21) parallèles l'une à l'autre développées dans une première direction principale L, le système comprenant une machine d'élimination de scories (5), un groupe de traction (10) de la machine (5), un guide coulissant linéaire (15) pour le groupe de traction, lesdits trois éléments étant associés l'un à l'autre de telle sorte que : le groupe de traction (10) est interposé de manière fonctionnelle entre la machine (5) et le guide (15), de manière à faire glisser la machine (5) vers le guide (15) le long d'une direction de traction L, et le groupe de traction (10) coulisse au moins partiellement le long du guide (15) le long d'une direction de coulissement W orthogonale à la direction de traction L, la machine d'élimination de scories comprenant des moyens d'outil aptes à enjamber, pendant ladite traction, au moins une desdites plaques (21) qui est orientée selon ladite première direction de développement L parallèle à ladite direction de traction L.
Patent EP-4115149-A1 (EP)
Inventor: GREEN RICHARD
IPC: G01P15/03
Filed: 2021-02-19
Abstract: An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.
Patent EP-4115759-A1 (EP)
Title: Clothing
Inventor: TANIGUCHI TAKAMITSU
IPC: A41D13/00
Filed: 2021-02-26
Abstract: Provided are clothes that can reduce the lack of elongation at a joined part and improve the wearing feeling during light exercise even when the clothes are composed by joining fabrics using an adhesive. The clothes according to the present invention include fabrics having a stretchability; and a joined part where the fabrics are fixed together using an adhesive, in which a difference between a stress of the joined part at 50% elongation in a longitudinal direction of the joined part and a stress of the fabrics fixed by the joined part at 50% elongation in a direction parallel to the longitudinal direction of the joined part is within 30%.
Patent EP-4200676-A1 (EP)
Title: System and method for auto-tagging bms points
Inventor: WANG QINPENG
IPC: H04L12/28
Filed: 2021-08-25
Abstract: There is described a building management system and a method for autotagging points. Data (402, 404) associated with multiple points of a site are received, and each point is associated with a point name (402, 404) and a point descriptor. A building name is identified (406) based on the point name for each point by extracting a first part detected frequently among the data associated with the points. A point equipment is determined (408) from a second part of each point name and a point function is determined (408) from a third part of each point name. A set of point tags is generated (424) based on the point equipment, the point function, and the point descriptor. Confidence scores are created (444) for the set of point tags based on matching characteristics to a common tag set.
Patent EP-4211512-A1 (EP)
Inventor: ROUGIER ALINE
IPC: G02F1/155
Filed: 2021-09-07
Abstract: L'invention concerne un dispositif électrochrome (50). Selon l'invention, il comprend : - au moins un substrat (51); - une première électrode (53) comportant une première ouverture (52) et une deuxième électrode (54) comportant une seconde ouverture (55); - les deux électrodes étant positionnées de sorte que les deux ouvertures soient en regard; - une couche de matériau électrochrome (56) adaptée pour être agencée par rapport à la première ouverture (52) de la première électrode de manière à former au moins une zone de contact électrique entre la couche de matériau électrochrome et la première électrode, ladite couche de matériau électrochrome et ladite première électrode formant ainsi ensemble une électrode de travail et la seconde électrode formant une contre-électrode; - une couche d'électrolyte (57) prise en sandwich entre l'électrode de travail et la contre-électrode; - un moyen d'alimentation électrique configuré pour appliquer une tension électrique aux deux électrodes.
Patent EP-4115700-A1 (EP)
Inventor: JUNG SANGYEOB
IPC: H04W76/18
Filed: 2021-04-09
Abstract: A terminal is configured to start a timer when a RRC connection establishment/resume procedure is initiated, identify that the timer is expired or that an integrity check failure indication is received while the timer is running, determine whether at least one of a first condition or a second condition is met, when at least one of the first condition or the second condition is met, set a count number about connection failure included in the information container to 0, and after determining whether at least one of the first condition or the second condition is met, clear contents included in the information container except for the count number about the connection failure.
Patent EP-4217340-A1 (EP)
Inventor: KARVE SHRIRANG
IPC: C07C309/69
Filed: 2021-09-22
Abstract: La présente invention concerne, en partie, des composés lipidiques à base de triéthylsilyle (TES) représentés par la formule (la), et ses sous-formules : ou un sel pharmaceutiquement acceptable de ceux-ci. Les composés de l'invention peuvent servir à l'administration et à l'expression d'ARNm et de protéine codée, par exemple, en tant que constituant d'un véhicule d'administration liposomale, et peuvent par conséquent servir à traiter divers troubles, maladies et affections, tels que ceux associés à une déficience en une ou plusieurs protéines.
Patent EP-4196097-A1 (EP)
Inventor: MERKEL OLIVIA MONIKA
IPC: A61K47/69
Filed: 2021-10-13
Abstract: Method for producing high yield nano-in-micro (NIM) encapsulated bioactive siRNA dry powder comprising the steps of: - providing an aqueous suspension comprising polyplexes, in particular polyelectrolyte complexes, formed from at least a polyamine, and/or polyamide and/or polyester and siRNA, wherein the polyplexes are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar; - spray drying the aqueous suspension using a spray drying apparatus, preferably a Büchi B-290, by feeding the aqueous suspension to a spray drying atomizing nozzle and subjecting the atomized droplets to a heated gas stream of a carrier gas, preferably dried and cleaned air, in particular through a multicomponent atomizing nozzle for the suspension and an atomizing gas; - collecting a spray dried powder in an accumulation means of the spray drying apparatus characterized in that the temperature in the vicinity of an outlet opening of the spray drying apparatus, in particular an outlet opening connecting a spray drying chamber with the accumulation means, during feeding of the aqueous suspension to the nozzle is controlled by temperature controlling means to be limited to an upper threshold temperature which is equal to or below a melting temperature of the respective naked siRNA.
Patent EP-4135227-A1 (EP)
Title: Communication method and apparatus
Inventor: HUANG KECHAO
IPC: H04L1/00
Filed: 2021-01-08
Abstract: This application provides a communication method and apparatus. The method includes: encoding a to-betransmitted first bit sequence to obtain a first matrix, where the first matrix includes a plurality of bit square matrices of a same size, and each bit square matrix includes a plurality of pieces of bit data; performing, based on a first mapping relationship, position transformation in a range of each bit square matrix on the bit data of each bit square matrix in the first matrix, to obtain a second matrix after the position transformation; and performing bit data position transformation among bit square matrices on the second matrix to obtain a third matrix, and modulating a to-be-sent first symbol sequence based on the third matrix. A row transformation mapping relationship in the first mapping relationship indicates a row identifier mapping relationship before and after position transformation of the bit data in the bit square matrix range. The row transformation mapping relationship may be constrained by using a global offset constraint factor and at least two local offset constraint factors. Aburst tolerance capability of information transmission can be improved.
Patent EP-4240424-A1 (EP)
Title: Composition comprising a combination of immune checkpoint inhibitor and antibody-amatoxin conjugate for use in cancer therapy
Inventor: KULKE MICHAEL
IPC: A61K47/68
Filed: 2021-11-04
Abstract: The present application relates to a composition comprising (a) at least one immune checkpoint inhibitor and (b) at least one conjugate, wherein said conjugate is comprising (i) a target binding moiety, (ii) at least one amatoxin, and (iii) optionally at least one linker connecting said target binding moiety with said at least one amatoxin. The present application further relates to said composition for use in treating a patient having a cancer, and to a pharmaceutical formulation comprising said composition and additional excipients, as well as to methods of producing and using said composition.
Patent EP-4151411-A1 (EP)
Inventor: KAMOHARA KAZUO
IPC: C09D11/54
Filed: 2021-04-12
Abstract: An ink set including an undercoat composition containing at least one of a polymerizable monomer A including a polymerizable monomer A1 having a ClogP value of 2.0 or less or an alkali-soluble polymer, and a surfactant, and an ink containing a polymerizable compound B, wherein, in the polymerizable monomer A, a ratio of a monofunctional polymerizable monomer is 30 mass% or more, the undercoat composition has an isocyanate compound content of, relative to a total amount of the undercoat composition, less than 10 mass%, a content of the alkali-soluble polymer relative to a mass of a solid content of the undercoat composition is 1 mass% to 20 mass%, relative to a unit molecular weight defined as 100, in the polymerizable compound B, a mass-ratio-based weighted mean of a number of functional groups per unit molecular weight is 0.65 or more, and the ink has a tri- or higher functional polymerizable compound content of, relative to a total amount of the polymerizable compound B, less than 10 mass%; and applications of the ink set.
Patent EP-3958980-A1 (EP)
Title: Targeted novel triazolothiadiazine derivatives for the treatment of lung cancer
Inventor: SEVER BELGIN
IPC: C07D285/16
Filed: 2021-01-22
Abstract: Within the scope of the invention, 15 novel 3-[2-(1,3-benzodioxole-5-yl)ethyl)]-6-aryl-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives were synthesized. The cytotoxic and apoptotic effects of some synthesized compounds in human lung adenocarcinoma (A549) cells through the inhibition of cyclooxygenase-2 (COX-2), Akt and/or Rho-protein kinase (ROCK) enzymes were determined.
Patent EP-4237675-A1 (EP)
Inventor: HACKMANN PHILIPP
IPC: F02D41/20
Filed: 2021-10-28
Abstract: Die Erfindung betrifft ein Verfahren zum Ermitteln eines Öffnungszeitpunkts eines Injektors mit einem Magnetventil. Das Verfahren umfasst: Ermitteln eines Ankeraufprallzeitpunkts, zu dem ein Anker des Magnetventils auf eine Ventilnadel des Magnetventils anschlägt; Ermitteln einer Öffnungsverzugszeits des Injektors, die einer Zeitspanne zwischen dem Ankeraufprallzeitpunkt und einem Öffnungszeitpunkt des Magnetventils entspricht; und Ermitteln eines Öffnungszeitpunkts des Injektors basierend auf dem Ankeraufprallzeitpunkt und der Öffnungsverzugszeit.
Patent EP-4155656-A1 (EP)
Inventor: KAWABATA RYOHEI
IPC: F28F9/02
Filed: 2021-03-12
Abstract: A heat exchanger has: a heat transfer tube group made up of plural heat transfer tubes each of which has, inside the heat transfer tube, a flow passage through which refrigerant flows, the plural heat transfer tubes that are arranged in a lateral direction being arranged in a longitudinal direction so as to form plural rows; a fin provided on the heat transfer tubes and facilitating heat exchange between refrigerant flowing inside the heat transfer tubes and air; and a bridging header into which end portions of the heat transfer tubes are inserted and that causes refrigerant to flow between the heat transfer tubes arranged in a lateral direction of the heat transfer tube group. The bridging header has a base having a flat plate shape and having insertion holes into which respective ones of end portions of the plurality of heat transfer tubes are inserted. The bridging header also has a corrugated sheet being a plate having a shape of a wave in which crest portions and valley portions are continuously formed, each of the crest portions being provided so as to cover a pair of the insertion holes arranged in a lateral direction, the valley portions being in contact with the base on both sides of each of the insertion holes in a longitudinal direction of the base, the corrugated sheet forming, between the corrugated sheet and the base, a header flow passage, through which refrigerant flows, for every the heat transfer tubes arranged in a lateral direction of the heat transfer tube group. The bridging header also has a covering plate covering the corrugated sheet and pressing the corrugated sheet toward the base.
Patent EP-4251761-A1 (EP)
Inventor: ROELOFS THEODORUS FRANK MARIA
IPC: C12Q1/6806
Filed: 2021-11-24
Abstract: The current invention pertains to a method for sequencing of a target nucleic acid fragment from a nucleic acid sample, comprising the steps of cleaving the nucleic acid sample with a first and a second RNA guided or DNA guided endonuclease complex, preferably a first and a second gRNA-CAS complex, thereby generating the target nucleic acid fragment and at least one non-target nucleic acid fragment. The generated fragments are subsequently contacted with an exonuclease, wherein the exonuclease digests only the non-target nucleic acid fragments. Subsequently said target nucleic acid fragment is sequenced using nanopore selective sequencing. The invention further pertains to the use of the enriched target nucleic acid fragments for nanopore selective sequencing the target nucleic acid fragment.
Patent EP-4157504-A1 (EP)
Inventor: MARRANO STEPHEN A
IPC: B01D21/24
Filed: 2021-05-28
Abstract: L'invention concerne des procédés et des appareils pour produire un substrat. L'invention concerne également un procédé et un appareil pour introduire un composant dans une alimentation en fluide. Un procédé peut consister à fournir une première alimentation en fluide. L'alimentation en fluide peut être configurée sous la forme d'une mousse dans certains modes de réalisation. Le procédé peut également comprendre la fourniture d'un système d'alimentation en composants et d'une alimentation du composant. Le procédé peut comprendre l'introduction du composant dans une alimentation en fluide dans un éjecteur selon certains aspects. Une suspension résultante comprenant une alimentation en fluide et le composant peut être transférée à travers une caisse de tête. La suspension résultante peut être déshydratée pour obtenir un substrat comprenant le composant.
Patent EP-4094915-A1 (EP)
Inventor: LEE HAN YOUNG
IPC: B29C43/04
Filed: 2021-04-29
Abstract: The present invention relates to a pouch forming apparatus comprising: a die, in which forming grooves are formed with a partition wall therebetween in a top surface of a pouch film; and a punch member provided with a punch, which is inserted into each of the forming grooves in a state of pressing the pouch film to form a pair of accommodation grooves in the pouch film, wherein the forming groove comprises a vertical space disposed above a forming groove bottom part connected to the partition wall and an inclined space connected to the vertical space and formed by providing one inner wall thereof facing the partition wall as an inclined surface, the punch comprises a vertical block inserted into the vertical space in a state of pressing the pouch film and an inclined block inserted into the inclined space in a state of pressing the pouch film, wherein one surface of the inclined block, which faces the one inner wall, is provided as an inclined surface, and one inner surface of the accommodation groove, which is disposed between the inclined surface of the inclined space and the inclined surface of the inclined block is formed into an inclined surface.
Patent EP-4161937-A1 (EP)
Inventor: SONG FENGTAO
IPC: A61K31/5383
Filed: 2021-06-03
Abstract: Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b][1,4] oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the use of such compounds for treating proliferative disease such as cancer.
Patent EP-4157814-A1 (EP)
Inventor: WAMPLER KEITH M
IPC: C07C6/04
Filed: 2021-06-01
Abstract: Disclosed herein are methods for synthesizing fatty olefin metathesis products of high Z-isomeric purity from olefin feedstocks of low Z-isomeric purity. The methods include contacting a contacting an olefin metathesis reaction partner, such as acylated alkenol or an alkenal acetal, with an internal olefin in the presence of a Z-selective metathesis catalyst to form the fatty olefin metathesis product. In various embodiments, the fatty olefin metathesis products are insect pheromones. Pheromone compositions and methods of using them are also described.
Patent EP-4256008-A1 (EP)
Inventor: GREAGER PHILIP IVAN
IPC: C10J3/72
Filed: 2021-12-01
Abstract: The present invention provides a process for obtaining solid recovered fuel and synthesis gas from a waste-based feedstock, comprising the steps of: I. converting the feedstock into a solid recovered fuel by means of a number of parameters pertaining to waste sorting, selection, comminution and/or screening; II. gasifying under suitable reaction conditions at least a portion of the solid recovered fuel to produce synthesis gas and by-product(s); and III. optionally cleaning at least a portion of the synthesis gas to produce clean synthesis gas and wastewater, wherein one or more of the solid recovered fuel, synthesis gas, and by-product(s) of the gasification are analysed during operation of the process, and wherein data from said analysis is used to control one or more parameters of step I) in order to influence reaction conditions in step II, and optionally step III).