baber/WOPTO huggingface dataset:
Patent EA-000696-B1 (EA)
Title: Prpcess for production of 2h-1-benzopyrans
Inventor: BOSSARD PIERRE
IPC: C07D311/72
Filed: 1997-08-13
Abstract: 1. Process for the production of 2H-l-benzopyrans with the general formula   where R<1> is hydrogen, a (C1-C4) alkyl group, R<2> is hydrogen, a (C1-C6) alkyl group and R<3> is hydrogen, a (C1-C4) alkyl group, a (C1-C4) haloalkyl group, a (C2-C4) alkenyl group, a (C1-C4) alkoxycarbonyl group, a (C1-C4) alkoxymethyl group, a (C1-C4) alkanoyl group, a (C1-C4) alkoxy group, a (C1-C4) alkylsulphonyl group, halogen, ammo, alkylamino, dialkylamino, nitril, nitro or hydroxy, characterised in that in a first stage an aliphatic aldehyde with the general formula   where R<1> and R<2> have the above-mentioned meaning, is converted with an aliphatic alcohol with the formula R<4>OH or HOR<4>OH, where R<4> is a (C1-C4) alkyl group or a (C2-C4) alkyldiyl group, in the presence of a dehydrating compound with the formula HC(OR<5>)3 where R<5> is a (C1-C4) alkyl group, and an aluminium oxide/silicium oxide catalyst into a aliphatic acetal with the general formula   where R<1> and R<2> have the above-mentioned meaning and R<4> as stated above is a (C1-C4) alkyl group or the two R<4> together are a cyclical (C2-C4) alkyldiyl group, and this is then condensed in a second stage with a phenol with the general formula   where R<3> has the above-mentioned meaning, in the presence of a base in an inert organic solvent to the end product with the general formula I. 2. Process according to claim 1 characterised in that the aluminium oxide/silicium oxide catalyst used in the first phase is a montmorillonite with a surface of 100 to 170 m<2>/g and a micropore volume (7.5 - 80 nm) of more than 0.15ml/g. 3. Process according to claim 1 or 2, characterised in that the aluminium oxide/silicium oxide catalyst used in the first stage is added in a quantity of 0.05 to 30% by weight in relation to the aliphatic aldehyde used. 4. Process according to claim 1, 2 or 3 characterised in that R<4> of the aliphatic alcohol R<4>OH used in the first phase and R<5> of the dehydrating compound HC(OR<5>)3 used in the first phase are ethyl. 5. Process according to at least one of claims 1 to 4 characterised in that R<4> of the aliphatic alcohol HOR<4>OH used in the first stage is ethane-1-2-diyl and R<5> of the dehydrating compound HC(OR<5>)3 used in the first phase is ethyl. 6. Process according to at least one of claims 1 to 5 characterised in that the reaction temperature at which the first phase is carried out is -40 to 40 degree C. 7. Process according to at least one of claims 1 to 6, characterised in that the base used in the second phase is an inorganic base. 8. Process according to claim 7, characterised in that the inorganic base used in the second phase is potassium carbonate. 9. Process according to at least one of claims 1 to 8 characterised in that the reaction temperature at which the second phase is carried out is 90 to 180 degree C. 10. Process according to at least one of claims 1 to 9 characterised in that the conversion is carried out without isolation of the intermediate product with formula III.
Patent EA-003211-B1 (EA)
Title: Method of obtaining of citric acid and its salts thereof by means of periodical continuous fermentation of fungus aspergillus niger
Inventor: AVCHIEVA PENKER BABAEVNA
IPC: C12R1/685
Filed: 2002-01-25
Abstract: 1. Method of manufacture of citric acid and its salts thereof by means of fermentation of fungus Aspergillus niger (VKPM) F-718, comprising a stage of preparing of seed grain, a following cultivation of said fungus in nutrient medium, that contains the sources of carbon, nitrogen, phosphorus and microelements, and recovering of target product, characterized that composition, which is used as stuff conidium at the stage of preparing of seed grain, comprises milled brans, peptone milled sugar, milled citric acid, and surfactant species, in particular, Tvin-40 is additionally introduced in cultivation medium, nitrogen and iron quantity is corrected in composition of nutrient medium depending on form of carbon source, pH medium at the initial fermentation stage is established on 4.-5.5. 2. Method according to claim 1, characterized that medium flow velocity at continuous fermentation mode is 0.5-0.6 h<-1>.
Patent EA-003337-B1 (EA)
Title: Fish grading device
Inventor: JOHNSON IVOR GIBERT
IPC: A01K61/90
Filed: 2000-11-03
Abstract: 1. A fish grading device comprising a framework of substantially rigid elongate members pivotally interconnected to form a plurality of loops, wherein each said loop is formed from a plurality of said substantially rigid elongate members and defines an aperture not exceeding predetermined dimensions. 2. A device according to claim 1, wherein each said substantially rigid elongate member can rotate about its longitudinal axis. 3. A device according to any one of the preceding claims, wherein each said substantially rigid elongate member is tubular. 4. A device according to anyone of the preceding claims, wherein the substantially rigid elongate members are interconnected by means of elongate flexible members. 5. A device according to claim 4, wherein the or each said elongate flexible member is a string or thread. 6. A device according to claim 4 or 5, wherein the or each said elongate flexible member forms a respective loop corresponding to each said loop of said interconnected substantially rigid elongate members. 7. A device according to claim 6, wherein at least one said substantially rigid elongate member is slidable longitudinally relative to the corresponding elongate flexible member. 8. A device according to any one of the preceding claims, wherein a plurality of said loops of elongate members are each formed from four said substantially rigid elongate members. 9. A device according to claim 8, wherein each of said loops of substantially rigid elongate members is substantially rectangular.
Patent EA-007542-B1 (EA)
Title: Novel block copolymers and method for making same
Inventor: HANDLIN DALE L JR
IPC: C08F2/00
Filed: 2003-02-07
Abstract: The present invention is a novel block copolymer containing a controlled distribution copolymer block of a conjugated diene and a mono alkenyl arene, where the controlled distribution copolymer block has terminal regions that are rich in conjugated diene units and a center region that is rich in mono alkenyl arene units. Also disclosed is a method for manufacture of the block copolymer.
Patent EA-010610-B1 (EA)
Title: Method of x-ray monitor of a test object and apparatus therefor
Inventor: GURZHIEV ALEXEY NIKOLAEVICH
IPC: H05G1/02
Filed: 2006-10-24
Abstract: The invention relates to applied physics, in particular, to technology of radiation detection.The technical aim is to develop an apparatus and an effective method for providing full high-accuracy full X-ray monitoring of a body being tested.The method comprises scanning of the object to be tested by a preformed flat X-ray beam formed in one any given plane-either in horizontal or in inclined-by moving the beam and the x-ray radiation detector relative to the object to be tested, at each moment of the monitor time each X-ray beam, the tested object and each detector of the X-ray radiation being in one plane.The apparatus is embodied as a bearing stand with guides, a bar and a C-shaped holder with a radiator and a linear detector fastened at ends thereof. The bar and holder are connected therebetween and to the bearing stand adapted to longitudinal movement and turn relative each other and relative to the bearing stand in the plane parallel to the bearing stand plane and in the plane perpendicular to the bearing stand plane.
Patent EA-009930-B1 (EA)
Title: Machine for carrying out a track gauge correction
Inventor: THEURER JOSEF
IPC: E01B27/17
Filed: 2005-09-08
Abstract: The invention relates to a machine (1) for carrying out a track gauge correction, comprising a multi-component machine chassis (6), provided with a stabiliser unit (11) and a satellite chassis (13), adjustable relative to the machine chassis (6) by means of a drive (31) and comprising a packing unit (9) and a track lifting unit (12). A second packing unit (9) is arranged between the satellite chassis (13) and the stabiliser unit (11) which may be displaced relative to the machine chassis (6) by means of a drive (27).
Patent EA-013745-B1 (EA)
Title: Prolonged release formulation of active principles which is zolpidem hemitartrate
Inventor: ALAUX GERARD
IPC: A61K9/24
Filed: 2006-06-26
Abstract: The invention concerns a novel formulation for prolonged release of an active principle which is zolpidem hemitartrate. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises one or more acidifying agents in the form of an acid salt of an organic acid, wherein the acid salt of an organic acid is monopotassium tartrate, monosodium tartrate, monosodium citrate, bisodium citrate, and mixtures thereof.
Patent EA-012786-B1 (EA)
Title: 3-aminocarbazole compounds, pharmaceutical composition containing the same and method for the preparation thereof
Inventor: ALISI MARIA ALESSANDRA
IPC: C07D209/88
Filed: 2006-07-25
Abstract: A compound of formula (I), in which R1 , R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.
Patent EA-012225-B1 (EA)
Title: Methods for in-situ formation of slots in a soderberg anode
Inventor: WANG XIANGWEN
IPC: C25C3/12
Filed: 2006-08-29
Abstract: A self-baking, Soderberg type carbon anode (40) for use in an aluminum electrolyses cell (1) to form product aluminum (11), where the anode (40) is consumable in molten electrolyte (12) in the cell, the anode having top, bottom and side surfaces and multiple layers of vertically disposed plate inserts (48) meltable in the molten electrolyte, the plate inserts (48) preferably made of aluminum and are capable of melting to create hollow slots (52) at the bottom of the anode facilitating any gas bubbles (60) generated to channel to the side of the anode into the electrolyte (12).
Patent EA-016325-B1 (EA)
Title: Method of preparation crystalline (r) tolterodine tartarate
Inventor: SVOBODA MARTIN
IPC: A61K31/137
Filed: 2007-08-09
Abstract: The invention relates to a method of preparing crystalline R- tolterodine tartarate, wherein: a) at least 90 % of all crystals are present in a size smaller than 30 [mu]m, b) at least 40 % of crystalline matter are smaller than 250 [mu]m, c) the maximum size of crystals does not exceed 800 [mu]m, d) the salt contains less than 0.1 weight % of the undesirable enantiomer S-tolterodine tartarate, e) analytical test for sulfate ashes (Pharm. Eur.) provides a value lower than 0.1%. The method of its preparation involves at least one crystallization from water.
Patent EA-019540-B1 (EA)
Title: Quinoline derivatives as pi3 kinase inhibitors
Inventor: ADAMS NICHOLAS D
IPC: A61K31/47
Filed: 2008-05-16
Abstract: The invention relates to 2,4-difluoro-N-{2-(methyloxy)-(5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide of formulaor a pharmaceutically acceptable salt thereof, a pharmaceutical composition based thereon and use said compound in the manufacture of a medicament for the treatment various cancers, wherein the cancer is selected from a group consisting of: ovarian cancer, pancreatic cancer, breast cancer, prostate cancer and leukemia.
Patent EA-014286-B1 (EA)
Title: Method for determining microemboli in cerebral blood flow
Inventor: ADASKIN ALEXANDER VLADIMIROVICH
IPC: A61B8/06
Filed: 2009-12-04
Abstract: A method for determining microemboli in cerebral blood flow using a Doppler ultrasound system comprises detection in said time zone Doppler signals of high intensity transistor signals, power of which exceeds averaged signal power of the background blood flow by at least the value of the predetermined threshold detection, wherein the detection of each next transistor signal – HITS, HITS,HITS, …HITSis carried out based on the averaged signal power of the background blood flow corrected subject to the power value of the detected previous transistor signal - HITS, HITS,HITS, …HITS. Further, the microemboli signals are determined among the detected transistor signals, for which detect “the core” of said signal at the amplitude-frequency characteristic of the high intensity transistor signal by defining a zone of the amplitude maximum arranged between two zones of amplitude local minimums. There detected the threshold value of “the core” power of the microemboli signal in the zone of the amplitude maximum, estimate the ratio between the power of each detected transistor signal in the zone of amplitude maximum to the power of said transistor signal for the whole its zone and find the microemboli signal in exceeding the value of said ratio of the predetermined threshold value of the “the core” power of the microemboli signal.
Patent EA-018618-B1 (EA)
Title: Hdac inhibitors
Inventor: KOVACH JOHN S
IPC: A01N43/78
Filed: 2008-10-01
Abstract: This invention provides the compound having the structure wherein n is 1-10; X is C-Ror N, wherein Ris H, OH, SH, F, Cl, SOR, NO, trifluoromethyl, methoxy, or CO-R, wherein Ris alkyl, alkenyl, alkynyl, C-Ccycloalkyl, or aryl; Ris H or NRR, wherein Rand Rare each independently H, C-Calkyl, or C-Ccycloalkyl; Ris OH or SH; and R, R, R, and Rare each independently H, OH, SH, F, Cl, SOR, NO, trifluoromethyl, methoxy, or CO-R, wherein Ris alkyl, alkenyl, alkynyl, C-Ccycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.
Patent EA-018114-B1 (EA)
Title: Device for power generation
Inventor: GOGICHEV VADIM
IPC: H01M6/04
Filed: 2009-04-24
Abstract: In a device (6) for power generation, having a first electrode (1) and a second electrode (2), a partition layer (3), which comprises at least one zwitterion compound and/or one radical compound, is disposed between the two electrodes (1, 2). After the two electrodes (1, 2) and the partition layer (3) are brought together, an external voltage is applied between the two electrodes (1, 2) for a specific period of time.
Patent EA-021597-B1 (EA)
Title: Method of hydrocracking and process for producing mineral oil
Inventor: TASAKA KAZUHIKO
IPC: C10G47/36
Filed: 2010-09-14
Abstract: A method of hydrocracking which comprises a wax-fraction hydrocracking step in which a wax fraction separated from a Fischer-Tropsch synthesis oil is hydrocracked to obtain a hydrocracking product; a gas-liquid separation step in which the hydrocracking product is separated with a multistage gas-liquid separator into gaseous matter, heavy-oil matter, and light-oil matter; a step for estimating the content of specific components in which the ratio of the flow rate of the heavy-oil matter to the flow rate of the light-oil matter is determined, and the content of specific hydrocarbon components in the hydrocracking product is estimated from the flow-rate ratio; and a control step in which the operation for the wax-fraction hydrocracking step is controlled on the basis of the estimated value so that the content of the specific hydrocarbon components is in a given range.
Patent EA-020966-B1 (EA)
Title: A process for the preparation and purification of solifenacin salts
Inventor: KLJAJIC ALEN
IPC: C07D453/02
Filed: 2010-07-09
Abstract: The invention relates to processes of preparation and purification of solifenacin salts, particularly to a process of crystallization of solifenacin succinate, leading to high purity of the obtained product as well as to the desired average particle size and desired modality of the particle size distribution.
Patent EA-023354-B1 (EA)
Title: Disposable wearing article
Inventor: TAKINO SHUNSUKE
IPC: A61F13/496
Filed: 2010-11-25
Abstract: The present invention provides a disposable wearing article having a rear waist region 14 which includes a rear waist main section 18 facing a front waist region 13 and a buttocks-covering section 19 lying adjacent to a crotch region 15. The rear waist main section 18 is divided into an upper area 31 lying adjacent to a waist-opening 22 and a lower area 32 lying adjacent to the crotch region 15 wherein a tensile stress per unit width dimension in the buttocks-covering section 19 is lower than a tensile stress per unit width dimension in the lower area 32 of the rear waist main section 18.
Patent EA-025304-B1 (EA)
Title: IMIDAZO[1,2-b][1,2,4]TRIAZINES AS c-Met INHIBITORS
Inventor: ZHUO JINCONG
IPC: C07D487/04
Filed: 2011-02-02
Abstract: The present invention relates to imidazo[1,2-b][1,2,4]triazines which are 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide or 2-chloro-N-[(1S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide; or to pharmaceutically acceptable salts of any of the above stated compounds, that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
Patent EA-030440-B1 (EA)
Title: Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
Inventor: JIANG PING
IPC: G01N33/574
Filed: 2012-10-24
Abstract: Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
Patent EA-028201-B1 (EA)
Title: Apparatus for forming a helical screw flight
Inventor: BLOXHAM GREGORY JOHN
IPC: B65G33/00
Filed: 2012-07-05
Abstract: Provided is an apparatus for forming a helical screw flight from an open ended annulus shaped blank. The apparatus includes a base, a fixed mounting frame arranged on the base, and a pair of selectively interchangeable fixed side plates. Said side plates are releasably mounted to the fixed mounting frame and are angled relative to one another. Each fixed side plate has an engaging portion for engaging a first side surface of the blank in a direction substantially normal to the mean radius line of the blank. Furthermore, the apparatus includes a movable mounting frame arranged on the base and being selectively movable relative to said fixed mounting frame, and a pair of selectively interchangeable movable side plates releasably mounted to the movable mounting frame and angled relative to one another. Each movable side plate has an engaging portion for engaging an opposed second side surface of the blank in a direction substantially normal to the mean radius line of the blank. Said fixed and movable plates are adapted to formingly engage the blank upon movement of the movable mounting frame towards the fixed mounting frame, thereby forming a twist in at least a portion of the flight blank between said side plates.
Patent EA-028361-B1 (EA)
Title: Coherent superheterodyne electron paramagnetic resonance spectrometer
Inventor: ROKEAKH ALEXANDER ITSEKOVICH
IPC: H01J49/00
Filed: 2015-07-14
Abstract: The invention relates to applied physics and can be used in making electron paramagnetic resonance (EPR) spectrometers. Spectrometer comprises signal 1 and heterodyne 2 microwave generators, measuring attenuator 3, mixer for reference 4 and signal 5 channels, circulator 6, measuring resonator 7 with its resonance frequency tuning element 8, reference amplifier 9 and 10 signalling channels, phase-frequency discriminators 11 and 12, frequency dividers 13 and 14, synchronous detectors 15 and 16, reference generator 17, frequency synthesis device 18, three-position switch 19, pulse modulator phase 20, alternating current amplifier 21 and pulse demodulator 22. The invention makes it possible to significantly increase accuracy of automatic frequency tuning system of signal generator and resonant frequency of measuring resonator.
Patent EA-033436-B1 (EA)
Title: 5-phenoxy-3h-pyrimidin-4-one derivatives and their use as hiv reverse transcriptase inhibitors
Inventor: ARRINGTON KENNETH L
IPC: C07D471/04
Filed: 2013-10-07
Abstract: Compounds of Formula (I)wherein R, R, R, N, M and Z have the meanings defined herein, are HIV reverse transcriptase inhibitors. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Patent EA-025635-B1 (EA)
Title: Imidazopyridazine derivatives as gabareceptor modulators
Inventor: OMOTO KIYOYUKI
IPC: C07D487/04
Filed: 2013-12-04
Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R, R, R, Rand Rare as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAreceptor, they are useful in the treatment of a number of conditions, including pain.
Patent EA-031780-B1 (EA)
Title: Mobile zooveterinary sheep treatment plant
Inventor: OSMONOV YSMAN DZHUSUPBEKOVICH
IPC: A61D11/00
Filed: 2016-07-27
Abstract: The invention is related to agriculture, in particular, to sheep breeding. The objective of the invention is development of a mobile plant for zooveterinary treatment of sheep in private and cooperative farms. The mobile zooveterinary sheep treatment plant comprises a dipper on wheels with a towing attachment, and process equipment. In the transport position, the process equipment is loaded into the dipper and is transported to the place of animal treatment by a tractor (general-purpose cultivating or low-powered tractor) or by UAZ car. In the working position, when the plant is deployed, it consists of four successive sections. A primary wool treatment section comprises a wool grading table, a wool mini-press, and a combing-and-washing device. A shearing, evaluation and veterinary treatment section includes racks with wool-clippers arranged around a circular pen for untreated sheep. An anti-scabious sheep treatment section has a dipper that is equipped with a flexible material stretched on a frame for sheep delivery into acaricide liquid. At the dipper output, a device for liquid removal from sheep wool is installed. A flock forming section is provided with races for sheep division into classes. For sheep treatment in pasture conditions where there are no electric lines, the plant is provided by HPP line for power supply to process equipment. The plant embodies a new combination and interconnection of arrangement of process equipment for zooveterinary sheep treatment. The plant is technically feasible, i.e., it is industrially applicable. Implementation of the plant solves the problems of zooveterinary sheep treatment with good quality, ecological and energy-saving indices and obtaining an economical effect.