baber/WOPTO huggingface dataset:
Patent CR-20140216-A (CR)
Title: 5,7-imidazo[1,2-c]pirimidinas sustituidas
Inventor: BOYS MARK LAURENCE
IPC: A61K31/519
Filed: 2014-05-09
Abstract: Compuestos de Fórmula I: y estereoisómeros y sales y solvatos farmacéuticamente aceptables de estos, donde R1, R2, R3, R4, R5, R6, X1 y X2 tienen los significados que se proporcionan en la memoria descriptiva, son inhibidores de una o más cinasas JAK y s
Patent CR-20140542-A (CR)
Title: Anticuerpos biespecíficos anti-vegf7anti-ang-2 y su utilización en el tratamiento de enfermedades vasculares oculares
Inventor: DUERR HARALD
IPC: C07K16/46
Filed: 2014-11-26
Abstract: La presente invención está relacionada con un anticuerpo biespecífico contra el factor de crecimiento endotelial vascular humano (VEGF/VEGF-A) y contra la angiopoyetina-2 humana (ANG-2) de subclase IgG1 o IgG4 humana con las mutaciones I253A, H310A, y H435A, los métodos para su producción, las composiciones farmacéuticas que contienen dichos anticuerpos, y las utilizaciones de los mismos.
Patent CR-20150195-A (CR)
Title: Proteínas ligantes de antígeno anti-her3/her4 de unión a la horquilla beta de her3 y la horquilla beta de her4
Inventor: BOSSENMAIER BIRGIT
IPC: C07K16/32
Filed: 2015-04-16
Abstract: La invención se refiere a proteínas ligantes de antígeno anti-HER3/HER4, por ejemplo anticuerpos anti-HER3/HER4, las cuales se unen a la horquilla beta de HER3 y a la horquilla beta de HER4, a métodos para seleccionar estas proteínas ligantes de antígeno, y a su preparación y utilización como medicamento.
Patent CR-20170384-A (CR)
Title: Derivados de nucleosidos sustituidos utiles como agentes antineoplasicos
Inventor: TATLOCK JOHN HOWARD
IPC: C07H19/24
Filed: 2016-02-15
Abstract: Los compuestos de la Fórmula general (I): procesos para la preparación de estos compuestos, composiciones que contienen estos compuestos y los usos de estos compuestos.
Patent CR-20200471-A (CR)
Title: Novel peptides and combination of peptides for use in immunotherapy against various tumors
Inventor: MAHR ANDREA
IPC: C07K14/47
Filed: 2016-03-24
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent EC-SP003843-A (EC)
Title: Derivados de tiazolilamida
Inventor: KELDENICH JOERG
IPC: C07D277/54
Filed: 2000-12-21
Abstract: La presente invención se refiere a nuevos compuestos, a un procedimiento para su preparación así como a su uso como medicamentos, especialmente como medicamentos antivíricos.
Patent EC-SP045415-A (EC)
Title: Polimorfo del ácido 4-[2-[4-[1-(2-etoxietil)-1H-bencimidazol-2-il]-1-piperidinil]etil]-a,a-dimetil-bencenoacético
Inventor: ORJALES VENERO AURELIO
IPC: A61K31/445
Filed: 2004-11-08
Abstract: Se describe el polimorfo 1 del ácido 4-[2-[4-[1-(2-etoxietil)-1H-bencimidazol-2-il]-1-piperidinil]etil]-a,a-dimetil-bencenoacético de fórmula (I), procedimientos para su preparación, formulaciones farmacéuticas conteniendo el polimorfo 1 y la utilización del polimorfo 1 para el tratamiento de reacciones alérgicas y de procesos patológicos mediados por la histamina en mamíferos, tales como el hombre.
Patent EC-SP077995-A (EC)
Title: Método para el tratamiento preventivo del polvo de material con propiedad de formación de polvo
Inventor: MIZUNO YOSHITOMO
IPC: C09K3/22
Filed: 2007-12-10
Abstract: Proporcionar un método para el tratamiento preventivo de la formación del polvo de un material formador de polvo usando un agente de tratamiento preventivo del polvo consistente en una dispersión acuosa de PTFE que tiene un menor potencial de causar problemas ambientales, cuyo método es tan efectivo como el método conocido y además tiene una menor posibilidad de problemas ambientales, y proporcionar el material tratado para la prevención del polvo obtenido por tratamiento del material formador de polvo con el método.El método de tratamiento preventivo del polvo para un material formador de polvo en el que se evita el polvo derivado del material formador de polvo mezclando una composición de tratamiento preventivo del polvo consistente en una dispersión acuosa de politetrafluoroetileno que contiene 50 ppm o menos de un emulsor que contiene flúor con el material formador de polvo y formando luego fibrillas de politetrafluoroetileno ejerciendo una fuerza de compresión/corte sobre la mezcla anterior a una temperatura de aproximadamente 20ºC a 200ºC, y el material tratado para la prevención del polvo obtenido tratando el material formador de polvo con el método.
Patent EC-SP982594-A (EC)
Title: Oxazolidinonas triciclicamente sustituidas
Inventor: ENDERMANN RAINER
IPC: C07D263/20
Filed: 1998-07-16
Abstract: La presente invención se refiere a oxazolidinonas triciclamente sustituidas, a procedimiento para su preparación y a su uso como medicamentos, en especial como medicamentos antibacterianos.
Patent FI-20001874-A (FI)
Inventor: LAHDENSIVU KIMMO
IPC: H04L29/12
Filed: 2000-08-24
Abstract: The present invention relates to a method for centralized configuration of a telecommunication network, which telecommunication network comprises one or more IP networks with their addresses. From a set of IP addresses, an IP alias is generated. In the method, a predetermined change is made at least in one service parameter of the IP alias or of the devices belonging to the IP alias; those IP additional services are defined whose parameters are affected by the change in question, and the necessary configuration changes are made in the devices generating the IP additional services in question. According to the invention, a device configuration database is created that comprises the configuration information of the additional service devices; the aforementioned change is focused on the IP alias in question, and the aforementioned configuration changes of the additional service devices are made automatically and in parallel utilizing the aforementioned device configuration database.
Patent FI-20045254-A (FI)
Inventor: LANNES PETTERI
IPC: B65H18/22
Filed: 2004-06-30
Abstract: A method in a reeler and a reeler, wherein a reeling nip (N1) is formed by a reeling core (5) or a growing machine reel (R) and at least one loop of an endless supporting member (1), which is substantially continuous in the axial direction of the reeling core (5). In the method the tension profile of the endless supporting member (1) is determined from the measured variables proportional to the tension of the endless supporting member (1).
Patent GB-1047400-A (GB)
IPC: H02K3/22
Abstract: 1,047,400. Dynamo-electric machine stators. SOCIETE GENERALE DE CONSTRUCTIONS ELECTRIQUES ET MECANIQUES (ALSTHOM). Nov. 29, 1963 [Nov. 29, 1962], No. 47264/63. Heading H2A. In a dynamo-electric machine e.g. turbo-alternator having a stator e.g. armature winding comprising a plurality of conductor bars 1 each composed of an assembly of elongated electrically conducting mutually electrically insulated elements of a metal or alloy e.g. Cu or A1 as pure as possible, the bars are insulated from each other, from their supporting magnetic core 7, and from the external environment by both a surrounding electrical insulator 6 and a thermal insulator 2 having a thermal conductivity substantially lower than that of the electrical insulator 6, the thermal insulator 2 surrounding the whole or part of the assembly and being partly hollow to form one or more fluid refrigerant receiving cooling channels 3 extending longitudinally of and adjacent the elements, and being spaced from the electrical insulator 6 by the thermal insulator 2. In the circular section embodiment shown, the elements are very small diameter wires mutually insulated by an oxide, enamel or synthetic material, twisted together to provide transposition, and thermosetting resin impregnated to increase rigidity. An axial channel 4 and extra thermal insulator 5 may be provided. A cryogenic apparatus may supply liquid refrigerant to the bars, where it converts to a gas and substantially reduces the bar resistance. In other embodiments the bars are of rectangular cross-section, formed of ribbons.
Patent GB-1050413-A (GB)
IPC: B22C5/08
Abstract: 1,050,413. Drying sand. W. G. KEMP. April 26, 1965 [April 25, 1964], No. 17241/64. Heading F4G. Apparatus for drying sand comprises a hopper 10 located in the mouth of a discharge funnel 13 and having a series of parallel heating tubes 14 connected to inlet and outlet manifolds at the base of the hopper which tubes are so spaced apart relative to the particle size of the sand that the wet sand bridges the gaps between the tubes but the dry sand may pass therethrough. The outlet manifold 17 may be connected to a further series of heating tubes in the bed of sand and the tubes may be heated by connection to a gas burner or fuel supply and ignition means, or by electric heaters in the tubes.
Patent GB-1051678-A (GB)
IPC: F16D35/00
Abstract: 1,051,678. Hydraulic couplings. MORSE CHAIN CO. Jan. 29, 1965 [Feb. 3, 1964], No. 4114/65. Heading F2C. A fluid shear coupling comprises a driving member 25, 26 defining an annular chamber 32 and angularly spaced reservoir chambers 33 and carrying shear plates 40 interleaved but spaced from shear plates 42 on a driven member 12 keyed at 19 to shaft 20; chambers 33 house resilient sealed cellular members 50 which become compressed when centrifugal forces on the fluid reach a certain value whereby fluid passes from chamber 32 so interrupting the transmission of drive when the driving member reaches a high speed. The members 50 expand with rising temperature to urge the fluid into chamber 32; the coupling being used to drive a fan in a water-cooled engine of a vehicle.
Patent GB-1051911-A (GB)
IPC: G01J1/36
Abstract: 1,051,911. Measuring light intensity. NORTH AMERICAN AVIATION Inc. July 30, 1963 [July 30, 1962]. No.30124/63. Heading G1A. A light intensity measuring instrument comprises means to pass light from first and second sources to an apertured plate, means for alternately interrupting light from the two sources, said means including a flexible member oscillatable at its resonant frequency and a detector for light, the output of which is compared with a reference signal in phase with the oscillation of the flexible member. Light from a test source 21 Fig. 1 and a reference source 32 is carried to adjacent points by optical systems including fibre optics bundles 28, 36. The light from the two sources is modulated in anti-phase by a vane 56 Fig. 2 on a rod 68 oscillating at its natural frequency. The oscillations are maintained by a magnetic capacitive or piezo-electric pick-off 70, which induces magnetic poles in rod 68 by means of a coil 66, the poles reacting to the field of a magnet 62 to maintain the oscillations. After modulation the light falls on a photomultiplier 38, the output thereof being compared in a phase sensitive rectifier 42 with a signal from the amplifier 72 to produce a D.C. signal which is used to adjust the light source 32 until the intensity of the sources is equal.
Patent GB-1226042-A (GB)
IPC: G21K1/06
Filed: 1968-11-05
Abstract: 1,226,042. Diffraction gratings. TOYOTA CENTRAL RESEARCH & DEVELOPMENT LABORATORIES Inc. Nov. 5, 1968, No.52334/68. Heading G2J. A diffraction grating for electromagnetic waves within a wide range from ultraviolet to long X-ray can be produced by polishing the crystal surfaces (110) and (123) of a high quality single crystal of aluminium by electrolytical means using an ethanol solution of perchloric acid. For mass production copies of the diffraction grating can be made by adhering softened, melted or partially dissolved high polymer material to the surface, allowing it to dry, and then removing the copied surface and sputtering it as described below. Several of these surfaces can be joined together to form a wide grating. The spacing between the lines (grating constant) of the aluminium grating can depend linearly on the length of time of electrolytic polishing. On directing an incident beam of light at the grating, the generation of an unwanted diffraction image which is practically indistinguishable from the spectroscopic image required may be avoided by sputtering materials such as gold, chromium or platinum, whose characteristic X-ray wavelength is shorter than the wavelength of incident light, on to the aluminium crystal. The clarity of the stripes on the crystal can be improved by annealing the crystal for a few days, before polishing.
Patent GB-1229129-A (GB)
IPC: B06B1/18
Filed: 1969-06-13
Abstract: 1,229,129. Pneumatic free-piston vibrationinducing device. BURGESS & ASSOCIATES Inc. June 13, 1969 [April 16, 1969], No.30192/69. Headings F1M and F1S. A pneumatic free-piston vibration-inducing device comprises in combination (a) a housing 10 including a cylindrical bore 12 closed at each end (b) gas inlet means including a centrally disposed inlet port 14 extending through the housing (c) gas exhaust means (not shown) including axially spaced exhaust ports extending through the housing and adjacent each end of the cylindrical bore (d) a cylindrical piston 30 having an apparent density less than the density of the housing and reciprocable in the cylindrical bore, the piston having an axial length greater than the axial distance between the exhaust ports and the piston including an annular shell 32 and means 34, 36 for closing each end thereof and (e) gas transfer means 46, 50 disposed in the piston and alternately coacting between the gas inlet means and the ends of the cylindrical bore respectively whereby the piston reciprocates in the bore to admit gas under pressure alternately to each end of the cylindrical bore. The piston may be composed of a thin steel outer shell surrounding an aluminium plug. The cavity defined by the annular shell and the end-plates may be filled with an epoxy resin. The cavity may be filled entirely with epoxy resin and the end-plates omitted.
Patent GB-1231233-A (GB)
IPC: E02D3/068
Filed: 1968-10-01
Abstract: 1,231,233. Percussive tools. LOSENHAUSEN MASCHINENBAU A.G. 1 Oct., 1968 [21 Oct., 1967], No. 46537/68. Heading B4C. A motor-driven implement with a vibratory tool, e.g. tamping foot 13 comprises an implement housing 10 and a tool housing 12 interconnected by a frame which is reciprocated by a motor 1 via a crank drive and which comprises a plurality of rods 8 joined at their upper and lower ends by members 7, 9. The rods slide in bushes 11 and compression springs 14, 15 are positioned between the upper closure of the tool housing and the members 7, 9. A sealing bellows 17 is provided between the housings. The tool housing contains oil which, upon upward movement of the member 9 relative to the tool housing, injects oil through an aperture in the upper closure to lubricate the bushes 11 of the implement housing.
Patent GB-1233010-A (GB)
IPC: B65D75/48
Filed: 1968-06-25
Abstract: 1,233,010. Boxes; closing bags. DIAMOND SHAMROCK CORP. 25 June, 1968 [18 July, 1967], No. 30304/68. Headings B8C and B8P. A thermoplastics container formed from a length of ribbed thin flexible sheet plastics tubing as described in Specification 1,200,190, has the following modifications. The container 50, Fig. 6, which may be multisided, has transverse seals 18 extending angularly from the ribs 25, 26, 35, 36 to give added rigidity. These are formed in the plastics tube immediately after the ribs 25, 26 by additional sealing rollers (16, 17), Fig. 1 (not shown) and after the ribs 35, 36 by additional sealing rollers (27, 28), Fig. 5 (not shown) in the apparatus described in Specification 1,200,190. Additionally, Fig. 9, a rectangular cross-sectioned container has two adjacent walls 81 adhered to form a wide rib 83 and a handle opening 86 is provided in this. The side &c. ribs are similarly provided with transverse seals (not shown).
Patent GB-1238822-A (GB)
IPC: H01J23/033
Filed: 1970-03-26
Abstract: 1,238,822. Travelling-wave tubes. THOMSON C.S.F. 26 March, 1970 [28 March, 1969], No. 15013/70. Heading H1D. The collector 30 of a travelling-wave tube is surrounded by a conductive sleeve 31 and insulating rods 34 are disposed between them to conduct heat away from the collector. The sleeve 31 is joined at one end to a ring 32 to which the rest of the tube (not shown) may be joined and the spacing between the ring 32 and the collector 35 is as small as possible to reduce the lens effect of the field between them. The rods 34 may be cylindrical and should be force-fitted between the sleeve 31 and the collector 30 so that they penetrate into the metal of the collector 30, and the coefficients of expansion of the materials should be such that this cold weld effect is not modified by baking to 400-450 C. during manufacture. The collector may be of copper, the rods 34 of alumina, and the sleeve of stainless steel.
Patent GB-1250268-A (GB)
IPC: D05B69/06
Filed: 1969-11-24
Abstract: 1,250,268. Treadles; hand wheels. SINGER CO. 24 Nov., 1969 [17 April, 1969], No. 57313/69. Headings B7E and B7J. [Also in Divisions D1 and F2] A treadle mechanism for a sewing machine comprises a flexible driving belt 55, a treadle 40 having a fulcrum (43, Fig. 1, not shown) for angular movement of the treadle when placed on a flat surface, and a spring 58, one end 54 of the belt being secured to the treadle at a point remote from the fulcrum, the other end 65 being secured to one end of the spring, the other end of the spring being anchored to the treadle near the said one end 54 of the belt. The treadle may be of wood, plastics or metal and may comprise two parts hinged together (at 46, Fig. 1, not shown) to facilitate storage. The belt laps the pulley 26 driving an armshaft 15 of the sewing machine through a one-way clutch 14 (see Division F2). The pulley 26 is rotatably mounted on an extension 21 secured at 20 to the armshaft. The handwheel 23 also journalled on extension 21 is releasably clamped to the extension by the clamp 39, 37 operated by a knob 36.
Patent GB-1253221-A (GB)
IPC: B65D83/16
Filed: 1968-04-23
Abstract: 1,253,221. Spray producers. OXFORD INDUSTRIAL AEROSOLS Ltd. 9 July, 1969 [23 April, 1968; 11 June, 1968 (2); 18 Feb., 1969], Nos. 19109/68,.27729/68, 27730/68 and 8831/69. Heading B2F. A spray nozzle member e.g. for an aerosol container or in spraying crops, comprises at least two fluid-jet forming passages 8, 9, Fig. 3, which converge so that the passage walls meet within the member, and a cavity 7 defined :by wall portions of each passage, the cavity being in open communication with the atmosphere through an outlet orifice, and the member comprises two pieces of material e.g. of plastics, viz. a first piece 3 defining the orifice and containing a tapering recess, and the second piece plug 12, having a tapering region disposed in the recess, the passages being defined by. the two pieces of material. The passages may be of circular (not necessarily of the same diameter) elliptical or rectangular configuration, and tapered smoothly or step-wise. There may be formed by grooves in the plug (Figs. 7 and 8, not shown), but need not intersect. Several ways of increasing fluid turbulence in the passages are disclosed, including the provision of a slotted flexible diaphragm covering the inlet ends of the passages. The shape of the spray produced, whether triangular, two or three peaked or of constant mass, may be regulated by increasing the thickness of the nozzle opening passages. The type of spray pattern formed can also be determined by reducing the size of the nozzle opening with a circular or diamondshaped lip (Figs. 15 and 16, not shown). The external surface of the nozzle member may be on a planar (as shown), concave or convex surface. Alternatively, it may protrude from the nozzle head.
Patent GB-1257123-A (GB)
IPC: A23K3/00
Filed: 1969-09-17
Abstract: 1,257,123. Preserving animal feedstuffs. BP CHEMICALS (U.K.) Ltd. 16 Sept., 1970 [17 Sept., 1969], No. 45749/69. Addition to 1,160,430. Heading A2B.  Preventing the growth of mould or bacteria in animal protein feedstuffs by treating the feedstuffs with a binary or ternary mixture of formic, acetic and propionic acids, wherein the amount of liquid added to the feedstuffs is not greater than 15% by weight of the feedstuffs and the total water content of the feedstuffs after addition of the acids is not' greater than 50% by weight. The acid is preferably used as an aqueous solution. An animal protein feedstuff is a feedstuff derived from an animal (excluding fish).
Patent GB-1264736-A (GB)
IPC: D05B47/00
Filed: 1970-06-16
Abstract: 1,264,736. Sewing machines. DURKOPPWERKE G.m.b.H. 16 June, 1970 [3 July, 1969], No. 29247/70. Heading DIG. In a lockstitch sewing machine with a thread cutter (not shown), to provide a needle thread supply for seam commencement, a rod 9 which is connected to actuating means for the thread cutter is operative directly before the cutting of the sewing threads to actuate in sequence a lever 14 which removes the thread tension (by engaging a thread tensioner 8), and a lever 16 with an eyelet which engages the needle thread between two fixed eyelets 5, 5a, disposed between a draw-off lever 3 and the needle eye, and draws out some thread. The lever 14 is actuated by an arm 11 coupled by adjustable pins 10, to the rod 9, and the lever 16 is actuated by a pin 16a of the lever being engaged by the end of a slot in the rod. The stroke of the eyelet is adjustable by means of an eccentric pivot pin 15 for the lever 16. The rod 9 may be connected by linkage to the thread cutter or actuated by a pneumatic ram or an electromaget connected to the cutter actuating means.
Patent GB-1265642-A (GB)
IPC: B61F5/30
Filed: 1970-01-06
Abstract: 1,265,642. Axle box guides. SCHWEIZERISCHE WAGONSUND AUFZUGEFABRIK A.G. SCHLIERENZURICH. 6 Jan., 1970 [20 Nov., 1969], No. 627/70. Heading B7L. A rail vehicle bogie frame 1 is attached to an axle box housing 15 by a shock damping guide comprising a guide pin 2 attached to the bogie frame, a casing 3 secured to the pin 2, two coaxial springs 6, 7 arranged concentrically around the guide pin and acting, via a thrust ring 10, on an annular friction member formed of a plurality of segmental friction bodies 50 supported on the axle box housing by a rubber ring having a crosssection substantially of inverted L-shape. The segmental friction bodies 50 comprise parts 12, main parts 13 and friction linings 14 and are shaped to provide in the annular friction member a conical surface 11 which co-operates with a conical surface on the thrust ring 10, the springs 6, 7 acting to press the friction linings 14 against the guide pin casing 3. Packing rings 18, 19 are provided in an annular recess in the thrust ring and around an aperture in the axle box housing respectively to prevent access of dirt to the friction surfaces between the casing 3 and linings 14. In an alternative embodiment, Fig. 2 (not shown), the inner spring (20) acts on a thrust ring (22) and the outer spring (21) acts on a support ring (26), the conical surfaces being provided between the support ring and the annular friction member. In a further embodiment, Fig. 3 (not shown), a thrust (32) and counter (33) ring are provided, conical surfaces being provided between the annular friction member and both these rings.