Patent SG-11201804721S-A (SG)
Title: Modulators of complement activity
Inventor: DEMARCO STEVEN JAMES
IPC: A61K38/12
Filed: 2016-12-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date ..... .....r .,„01 22 June 2017(22.06.2017) WIPO I PCT II (10) 11111111111111111111111 WO International EOM 2017/105939 Publication 1111111111111111111111111t111111111IIIIII Number Al (51) International Patent Classification: #1, Cambridge, Massachusetts 02139 (US). TOBE, Sylvia; A61K 38/12 (2006.01) A61P 37/02 (2006.01) 3 Dodge Street, Cambridge, Massachusetts 02139 (US). A61P 7/00 (2006.01) A61M 5/30 (2006.01) TRECO, Douglas A.; 87 Brantwood Road, Arlington, Massachusetts 02476 (US). (21) International Application Number: PCT/US2016/065228 (74) Agents: WARD, Donna T. et al.; DT Ward, P.C., 142A Main Street, Groton, Massachusetts 01450 (US). (22) International Filing Date: 7 December 2016 (07.12.2016) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/268,360 16 December 2015 (16.12.2015) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/331,320 3 May 2016 (03.05.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/347,486 8 June 2016 (08.06.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (71) Applicant: RA PHARMACEUTICALS, INC. [US/US]; SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 87 Cambridge Park Drive, Cambridge, Massachusetts TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 02140 (US). ZW. (72) Inventors: DEMARCO, Steven James; 80 King George (84) Designated States (unless otherwise indicated, for every Drive, Boxford, Massachusetts 01921 (US). ARATA, kind of regional protection available): ARIPO (BW, GH, Michelle Denise; 10 Overlook Ridge Drive, Unit 328, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, Malden, Massachusetts 02148 (US). PARKER, Grace UG, (AM, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Victoria; 49 Dover St., Apt #48, Somerville, Massachu- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, setts 02144 (US). RICARDO, Alonso; 35 Pleasant Street, [Continued on next page] (54) Title: MODULATORS OF COMPLEMENT ACTIVITY (57) : The invention present relates to polypeptide modulators of Fig. 9A complement activity, including cyclic Included polypeptide modulators. are -*-- Plasma Concentration - R5000 methods of utilizing such modulators as therapeutics. - 0 - %Hemolysis - R5000 --*-- %Hemoiysis Placebo - 10000 4 8 000 2 Y . tn , ,,, V. _ XJ >: 000 U'1 0 0 8 E 0 4) C 000 r 3 1-1 .4t en CN IC o 1-1 It - -- 1-1 O ei i?\"-9 i 48 96 time (h) 192 2000 i s O WO 2017/105939 Al MIDEDIM01101DERDEEMOM0101111111111111111011110111011110111111 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Published: SM, GW, TR), KM, OAPI (BF, BJ, CF, CG, CI, ML, MR, NE, SN, TD, TG). CM, GA, GN, GQ, with — with international search report (Art. 21(3)) sequence listing part of description (Rule 5.2(a))