Patent SG-11201908879R-A (SG)
Title: Systems and methods for manufacturing biologically-produced products
Inventor: LOVE J CHRISTOPHER
IPC: C07K14/56
Filed: 2018-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT 1111111111110110101011111011010 111 0111111001101111110 11110# (10) International Publication Number WO 2018/183971 A8 (51) International Patent Classification: CO7K 14/535 (2006.01) C07K 14/56 (2006.01) C12M 1/00 (2006.01) C07K 14/61 (2006.01) C12M 1/34 (2006.01) C07K 16/00 (2006.01) (21) International Application Number: PCT/US2018/025582 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/480,436 01 April 2017 (01.04.2017) US 62/480,438 01 April 2017 (01.04.2017) US 62/480,422 01 April 2017 (01.04.2017) US 62/480,426 01 April 2017 (01.04.2017) US 62/480,428 01 April 2017 (01.04.2017) US 62/480,432 01 April 2017 (01.04.2017) US 62/480,435 01 April 2017 (01.04.2017) US 62/480,430 01 April 2017 (01.04.2017) US 62/480,427 01 April 2017 (01.04.2017) US 62/480,418 01 April 2017 (01.04.2017) US 62/533,765 18 July 2017 (18.07.2017) US 62/553,105 31 August 2017 (31.08.2017) US 62/644,285 16 March 2018 (16.03.2018) US 62/646,236 21 March 2018 (21.03.2018) US (71) Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue, Cambridge, MA 02139 (US). RENSSELAER POLY- TECHNIC INSTITUTE [US/US]; 110 8th Street, Troy, NY 12180-3590 (US). (72) Inventors: LOVE, J. Christopher; 227 Summer Street, Unit #2, Somerville, MA 02143 (US). LOVE, Kerry, R.; 227 Summer St, Unit 2, Somerville, MA 02143 (US). CROWELL, Laura; 68 Berkshire St., Apt. #2, Cambridge, MA 02141 (US). STOCKDALE, Alan; 124 Woodbine St., Providence, RI 02906 (US). BRAATZ, Richard, Dean; 8 Stoney Brook Road, Arlington, MA 02476 (US). ENSHEN LU, Amos; 62 Plymouth Street, Cambridge, MA 02141 (US). CRAMER, Steven; 783 Trottingham Dr., Niskayu- na, NY 12309 (US). TIMMICK, Steven; 1425 Locust St., Unit 6B, Philadelphia, PA 19102 (US). VECCHIAREL- cc LO, Nicholas; 404 McChesney Avenue, Ext. 26-9, Troy, NY 12180 (US). MASCARENHAS, Craig, A.; 84 Lawton Street, Apt. 2, Brookline, MA 02446 (US). GOODWINE, Chaz; 149 2nd Street, Apartment 2F, Troy, NY 12180 (US). (74) Agent: FULLER, Renee, C.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (48) Date of publication of this corrected version: 25 October 2018 (25.10.2018) (15) Information about Correction: see Notice of 25 October 2018 (25.10.2018) 1-1 cN (54) Title: SYSTEMS AND METHODS FOR MANUFACTURING BIOLOGICALLY-PRODUCED PRODUCTS (57) : Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit O and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products. C Cr) GC 1-1