baber/WOPTO huggingface dataset:
Patent SG-11201407249X-A (SG)
Title: Fabrication of nanopores using high electric fields
Inventor: KWOK WING HEI
IPC: G01N33/487
Filed: 2013-05-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/167955 A1 (51) International Patent Classification: C25F 3/14 (2006.01) B23K 9/013 (2006.01) B23B 41/14 (2006.01) B82Y30/00 (2011.01) B23H 9/14 (2006.01) C25F 7/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/000891 7 May 2013 (07.05.2013) English (30) Priority Data: 61/643,651 61/781,081 7 May 2012 (07.05.2012) 14 March 2013 (14.03.2013) English US US (71) Applicant: THE UNIVERSITY OF OTTAWA [CA/CA]; 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). (72) Inventors: KWOK, Wing Hei; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). TABARD-COSSA, Vincent; The University of Ottawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). BRIGGS, Kyle, Alexander, Zarkel; The University of Ot­ tawa, 3042-800 King Edward, Ottawa, Ontario KIN 6N5 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: FABRICATION OF NANOPORES USING HIGH ELECTRIC FIELDS 41 FIG. 4A o\ i> 0 © © © © 0000°© ° t t t t t t /© © ©© _ '© © © ® i-H o CJ (57) Abstract: A method is provided for fabricating nanopore a in a membrane. The method includes: applying an electric potential across the membrane, where value of the electric potential is selected to induce an electric field which causes leakage current a across the membrane; monitoring current flow across the membrane while the electric potential being applied; detecting an abrupt is increase in the leakage current across the membrane; and removing the electric potential across the membrane in response to detect - ing the abrupt increase in the leakage current.
Patent SG-11201407534P-A (SG)
Title: New diazaspirocycloalkane and azaspirocycloalkane
Inventor: HUNZIKER DANIEL
IPC: C07D471/10
Filed: 2013-06-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/186159 A1 (51) International Patent Classification: C07D 249/18 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01) C07D 205/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) A61K31/438 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/061890 10 June 2013 (10.06.2013) English (30) Priority Data: 12171839.9 13 June 2012 (13.06.2012) English EP (71) Applicant (for all designated States except US): F. HOFF­ MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; 340 Kingsland Street, Nutley, New Jersey 07110 (US). (72) Inventors: HUNZIKER, Daniel; Buerklistrasse 14, CH- 4313 Moehlin (CH). MATTEI, Patrizio; Doernliweg 33, CH-4125 Riehen (CH). MAUSER, Harald; Inzlinger- strasse 1, CH-4125 Riehen (CH). PRUNOTTO, Marco; Rue De la Moliere, 22, CH-2800 Delemont (CH). ULLMER, Christoph; Neumattenstrasse 6, 79592 Fisc- hingen (DE). (74) Agent: SALUD, Carlos; Grenzacherstrasse 124, CH-4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE R Y W R' o\ T-H 00 (I) (57) Abstract: The invention provides novel compounds having the general formula (I), wherein R , 1 R , 2 Y and W are as described O herein, compositions including the compounds and methods of using the compounds. N
Patent ZA-9578-B (ZA)
Title: Fabric filter
Inventor: JOHNSON HOWARD FREEMAN
IPC: B01D46/02
Filed: 1995-01-06
Abstract: PCT No. PCT/AU94/00738 Sec. 371 Date Jul. 9, 1996 Sec. 102(e) Date Jul. 9, 1996 PCT Filed Dec. 1, 1994 PCT Pub. No. WO95/18662 PCT Pub. Date Jul. 13, 1995The present invention provides a fabric filter apparatus and a method of feeding dusty gas to the dusty gas section of a fabric filter apparatus. The housing (11) of the fabric filter apparatus includes at least one substantially vertically extending duct (13) the lower end of which is in fluid communication with the dusty gas inlet (31). The duct diverts a portion of the dusty gas entering the fabric filter apparatus and delivers it to a corner of the housing (11) at a position intermediate the level of the porting plate (40) and the bottom of the circular filter bag array (50).
Patent AT-402627-B (AT)
Title: Number plate having illuminated characters
IPC: B60R13/10
Filed: 1989-04-18
Granted: 1997-07-25
Abstract: In the case of a number plate 4 having illuminated characters 3 with a plurality of punched-out character parts, to which plate a light-distributing cover made of transparent or transluscent plastic is adhesively fastened and which has small light bulbs for illuminating the character parts, the light-distributing cover has a number of square, pyramid-shaped projections 9 formed on it which are arranged between the number plate and the small light bulbs in regions corresponding in each case to the divisions of the small light bulbs; each of the square, pyramid-shaped projections 9 can have an apex angle θ lying in the range of from 90 degree to 160 degree. <IMAGE>
Patent HU-218603-B (HU)
Title: Target specific antibody-superantigen conjugates and their preparation
Inventor: AKERBLOM EVA
IPC: A61K47/48
Filed: 1991-07-16
Abstract: A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regimen for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.
Patent HU-201429-B (HU)
Inventor: MESZAROS ANTAL
IPC: H02G5/04
Filed: 1987-02-27
Abstract: A találmány tárgya villakeresztmetszetű szigetelő szerkezet áramvezető sínhez vagy sínrendszerhez, különösen kötött pályán mozgatható berendezések csuszóérinkezős áramszedők segítségével történő áramellátására, amely szigetelő szerkezetben rugalmas szigetelő anyagból, villaszerűén kialakított sínszigetelő (1) szárlemezeinek (4) a tövénél áramvezető sín (8) befogadására és bepattintás utánni megfogására alkalmas üreg van kialakítva, míg a szárlemezeket (4) összekötő nyak (2) a nyak (2) keresztmetszetének az áramvezető sín (8) irányára merőleges méreténél nagyobb azonos irányba eső méretű felfogó gerinccel (3) egy darabot képezően van kialakítva. A leírás terjedelme: 8 oldal, 1 ábra  1. óbro CM  -1-
Patent YU-48407-B (YU)
Title: Toplovodni kotao sa dodatnim konvektivnim uredjajem za iskorišćavanje toplotne energije dimnih gasova
Inventor: VLADIMIR CRNJANSKI
Filed: 1995-06-20
Abstract: TOPLOVODNI KOTAO SA DODATNIM KONVEKTIVNIM UREDJAJEM ZA ISKORIŠĆAVANJE TOPLOTNE ENERGIJE DIMNIH GASOVA na prednjem donjem delu ima vrata 3 ložišta sa otvorom 4 za smeštaj gorionika i otvore 7 za primarni vazduh i vrata 12 za uklanjanje šljake i pepela, sa otvorima 13 za sekundarni vazduh, a na gornjem delu ima dimni kanal 18 sa regulacionim klapnom 19, naznačen time, što se sastoji iz osnovnog kotla (1) i funkcionalno povezanog konvektivnog uredjaja (2), što je prostor izmedju oplate (21) kotla i ložišta (6), sa izmenljivom rešetkom (5) za sagorevanje čvrstog goriva, ispunjen vodom (8) za potrebe grejanja, i što je konvektivni uredjaj (2) povezan sa gornjim delom ložišta (6) i sastoji se od pet dimnih cevi (14) izmedju kojih cirkuliše voda (15) za sanitarne potrebe, pri čemu je centralna dimna cev većeg prečnika od četiri dimne cevi koje su postavljene oko nje. - Prijava sadrži još 2 zavisna zahteva.
Patent YU-48759-B (YU)
Inventor: NICHOLAS VERNON M
IPC: C07H13/04
Filed: 1991-04-20
Abstract: Postupak koji se sastoji u ekstrahovanju 1,3-diaciloksi-1,1,3,3-tetra(hidro-karbil)distanooksana iz smeša koje sadrže 1,3-diaciloksi-1,1,3,3-tetra(hidro-karbil)distanooksan, 6-estar saharoze i polarni aprotičan rastvarač, naznačen time, što obuhvata: (a) dovođenje u dodir navedne smeše, u prisustvu male količine vode, sa organskim rastvaračem koji se pretežno ne meša sa vodom, da bi se stvorila ekstrakciona smeša, pri čemu je količina upotrebljene vode dovoljna da izazove efikasnu raspodelu navedenog 1,3-diaciloksi-1,1,3,3-tetra(hidrokarbil)distanooksana, iz prve faze, koja sadrži navedeni polarni aprotičan rastvarač, u drugu fazu, koja sadrži navedeni organski rastvarač, (b) mućkanje ekstrakcione smeše toliko dugo a pri temperaturi, dovoljno da se pritom obrazuje dvofazna smeša, u kojoj se pretežni deo 1,3-diaciloksi-1,1,3,3-tetra(hidrokarbil)distanooksana, prisutnog u ekstrakcionoj smeši, nalazi u drugoj navedenoj fazi, a pretežno sav 6-estar saharoze, prisutan u ekstrakcionoj smeši, nalazi u navedenoj prvoj fazi, i (c) razdvajanje navedene prve faze od navedene druge faze. - Prijava sadrži još 9 zavisnih zahteva.
Patent ZA-88639-B (ZA)
Title: Substituted 3-phenyl-7h-thiazolo(3,2-b)(1,2,4)triazin-7-ones,a process for the preparation thereof,medicaments containing same and the use thereof,and also some intermediates formed in the preparation of the compounds mentioned
Inventor: THORWART WERNER
IPC: C07D513/04
Filed: 1988-01-29
Abstract: Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed   <IMAGE> (I)  in which R1, R2 and R3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.
Patent ZA-97107-B (ZA)
Title: Non-cationic systems for dryer sheets
Inventor: KNOWLTON CHARLES NATHANIEL
IPC: C11D1/22
Filed: 1997-01-07
Abstract: Tumble dryer articles having a fabric conditioning composition providing anti-static softening, stain removal, stain guard and anti-active build-up benefits in an automatic clothes dryer are described. The composition comprises 3 to 80 wt. % of a nonionic surfactant having an HLB value of greater than 11, 3 to 50 wt. % of an anionic surfactant, 0 to 80 wt. % of a non-surfactant release aid and up to 25 wt. % of an aqueous ingredient provided the total amount of the nonionic and anionic surfactant is 20 wt. % or more and the ratio of the aqueous ingredient to the anionic surfactant is less than 2:1.
Patent AT-407239-B (AT)
Title: Motor vehicle light unit
IPC: B60Q1/04
Filed: 1998-07-17
Granted: 2001-01-25
Abstract: A motor vehicle light unit with double headlights and integrated clearance and indicator light with an all- encompassing, in particular smooth cover pane and a frame, with the characteristic that the frame 1 has a rear wall 4 only in the region of the indicator light and that the double headlight unit 6 is, in a known fashion, without a back wall and can be adjusted with respect to the frame 1, also in a known fashion, and can additionally be pivoted about a horizontal axis, preferably by means of an actuating motor, is suggested. <IMAGE>
Patent AT-402466-B (AT)
Title: Installation for the metered dispensing of fodder to a plurality of dispensing points
IPC: A01K5/02
Filed: 1995-09-27
Granted: 1997-05-26
Abstract: In an installation for the metered dispensing of fodder to a plurality of dispensing points 10, with a conveying line 1 which is capable of being supplied with fodder from a mixer and which can additionally be subjected to compressed air via lines and shut-off members, and with outlet lines 9 which are assigned to the dispensing points 10 and which can be opened individually via shut- off members 2, 3, 8, in order to simplify the routing of the conveying line 1 and reduce the number of shut-off members 2, 3 in the conveying line 1 in each case two or more outlet lines 9, 18 capable of being opened individually via their shut-off members 8, 17 are connected via a distributor 6, 7, 16 to common branch-off valves 2, 3, 12 or the like of the conveying line 1, 11. <IMAGE>
Patent AT-380964-B (AT)
Inventor: SCHUCH ALBERT ING
IPC: G03B21/10
Filed: 1984-10-05
Granted: 1986-08-11
Abstract: A folding slide viewer has a rear projection screen which swings into a first position for storage. In a second, operating position, the projection screen it is provided with a lightproof bellows. The optical axis of the lens system is inclined at an angle with respect to the horizontal base of the housing. A reflector is along the optical axis of the lens system, when the screen is in its operating position, to reflect an image onto the screen. An image trap is swingable between a first position perpendicular to a longitudinal axis of the slide magazine and a second position perpendicular to the optical axis of the lens system.
Patent DK-164661-B (DK)
Inventor: CASARA PATRICK JACQUES
IPC: C07C/
Filed: 1983-05-16
Abstract: <CHEM>
     (R,S)- and (S)-4-amino-hepta-5,6-dienoic acid of the formula (III) are novel inhibitors of gamma-aminobutyric acid transaminase (GABA-T).
Patent DK-156566-B (DK)
Inventor: LAFON LOUIS
IPC: C07C215/22
Filed: 1983-10-26
Abstract: 1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE : 3-amino-1-phenoxy-2-propanol derivative, characterized in that it is selected from the group constituted by (i) the 3-alkylamino-1-(2-chloro-3,5-dimethoxyphenoxy)-2- propanols responding to the general formula  see diagramm : EP0110746,P12,F1 in which R is CH(CH3 )2 or C(CH3 )3 ; and (ii) their addition salts. 1. Claims for the contracting state : AT Use of a 3-amino-1-phenoxy-2-propanol derivative, selected from the group constituted by (i) the 3-alkylamino-1-(2-chloro-3,5-dimethoxyphenoxy)- 2-propanols responding to the general formula :  see diagramm : EP0110746,P13,F1 in which R is CH(CH3 )2 or C(CH3 )3 ; and (ii) their non toxic addition salts for manufacturing a drug.
Patent DK-165142-B (DK)
Inventor: BRIEKE HANS-GUENTER
IPC: F28F9/02
Filed: 1987-10-07
Abstract: 1. Apparatus for heat exchange between a recycle gas leaving an NH3 -converter and water, comprising heat exchanger tubes (11a, 11b) through which the recycle gas flows and which are gas-tightly connected to at least one tube plate (6) separating a pressure-resistant pre-chamber (5) and a heat exchanger chamber (3), wherein the pre-chamber (5) has at least one bell (10) for supplying the recycle gas and a collecting chamber surrounding the bell (10) for carrying away the cooled recycle gas, characterised in that the tube plate (6) is additionally provided with cooling bores (12) through which flows a water/steam mixture and which do not completely pass through the tube plate (6) from the heat exchanger side and which are communicated in their base regions by way of feed bores (13) with a water supply (14) through which the supplied water is fed into the heat exchanger chamber (3) by way of the cooling bores (12), and that the supply conduit to the externally cooled bell (10) is arranged in the associated outlet connection (7) of the pre-chamber (5) and the remaining annular space (9) in the outlet connection (7) has cooled recycle gas flowing therethrough.
Patent FI-67958-B (FI)
Inventor: FLADDA GERDT
IPC: G01N15/14
Filed: 1981-07-21
Granted: 1985-02-28
Abstract: Method and device for determining the concentration of a substance, which is bound to particles in a flowing medium (1), which substance can prevail in varying concentration. The determination is carried out by light beams (2) so selected, that the substance is absorbent for the radiation within a certain wavelength range, while the remainder of the particle material is reflecting. By means of a detector (4) the radiation is determined which passes straight through the flowing medium, and by means of a detector (5) the radiation is determined which is scattered in a certain direction by the particles in the medium. The concentration is calculated from the equation  (FORMULA)  where I<uo>u is the intensity of incident radiation, I<ur>u is the intensity of radiation which has passed straight through the medium, Is is the intensity of detected scattered radiation, k is a constant between 1/2 and 1 depending on the detection angle for the scattered radiation, and A, c<u1>u, c<u2>u, c<u3>u are constants.
Patent FI-75650-B (FI)
Inventor: WIREDAL HARRY ARTUR INGVAR
IPC: E21B10/40
Filed: 1982-01-20
Granted: 1988-03-31
Abstract: A drill tool for rotary and/or percussion drilling with drill rod means (14) within casing tube means (15) comprises a centric cutting bit (11) and an eccentric reamer cutter (12), both provided with hard metal inserts. For purposes of obtaining a life of the drill tool as long as possible the first frontal insert (23) on the reamer cutter (12) is positioned in front of the first peripheral insert (18) when seen in the rotational direction (D) during drilling, and the centric cutting bit (11) provided with more inserts on the half (38) of its front surface opposed to the reamer cutter (12) during drilling than on the other half (39).
Patent FI-77313-B (FI)
Inventor: MATIERE MARCEL
IPC: E21D11/08
Filed: 1983-07-14
Granted: 1988-10-31
Abstract: PCT No. PCT/FR82/00177 Sec. 371 Date Jul. 15, 1983 Sec. 102(e) Date Jul. 15, 1983 PCT Filed Oct. 29, 1982 PCT Pub. No. WO83/01823 PCT Pub. Date May 26, 1983.A method for producing cylindrical hollow bodies bearing on the ground along one generatrice, of large cross sectional area, by assembling on site previously prepared longitudinal components. The method consists in determining by calculation the optimum cross-sectional profile of said hollow body as a function of known parameters concerning the site, conditions of use of said hollow body and its inherent characteristics; divising said optimum cross-sectional profile into adjacent sections each corresponding to a longitudinal component of the hollow body and together providing a substantially continuous interior surface; and giving the transverse wall section of at least some of said components a variable thickness for adapting the latter component to the stresses to be exerted thereon.
Patent FI-72094-B (FI)
Inventor: SCHEDWIN SVEN-ERIK
IPC: B25J17/00
Filed: 1983-08-26
Granted: 1986-12-31
Abstract: Improved arrangement for transferring heavy work pieces from a transport or storage position to at least one machining position or reverse. According to the invention this is achieved by means of a pair of arms (13) which are telescopically extendable for bridging the distance between said positions and by means of support means (14, 15) which, in the fully or partly extended position for the arms (13), engage and support the arms adjacent their outer ends.
Patent FI-76798-B (FI)
Inventor: MARYANOFF BRUCE E
IPC: C07D207/40
Filed: 1984-06-21
Granted: 1988-08-31
Abstract: Novel compounds are disclosed, which are derivatives of 1, 2, 3, 5, 6, 10b-hexahydropyrrolo [2, 1-a]- isoquinolines, represented by general formula (I): <CHEM> as well as pharmaceutical compositions and methods for the treatment of depression in warm-blooded animals, e.g., man. Novel intermediates are also part of the invention.
Patent FI-87557-B (FI)
Inventor: IWASAKI TAMEO
IPC: C07C45/00
Filed: 1986-01-09
Granted: 1992-10-15
Abstract: Naphthalene derivatives of the formula:whereinR<sup>1</sup> is hydrogen atom or a lower alkoxycarbonyl andR<sup>2</sup> is a lower alkoxycarbonyl, or R' and R<sup>2</sup> are combined together to form a group of the formula:each of R<sup>3</sup> and R<sup>4</sup> is a lower alkoxy, or one of R<sup>3</sup> and R<sup>4</sup> is hydrogen atom and the other is a lower alkoxy, andRing A is a substituted or unsubstituted benzene ring, and a pharmaceutically acceptable salt thereof are disclosed. Said naphthalene derivative (I) and its salt have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arteriosclerosis. Disclosed are also a process for the production of compounds of formula (I), the use of said compounds and the production of medicaments and pharmaceutical compositions containing compounds of formula (1) as active ingredient.
Patent FI-95573-B (FI)
Inventor: CROSS PETER EDWARD
IPC: A61K31/40
Filed: 1990-03-16
Granted: 1995-11-15
Abstract: Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- <CHEM>  and their pharmaceutically acceptable salts,  wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-;  R is -CN or -CONH2;  and R<1> is a group of the formula:- <CHEM>  where X and X<1> are each independently O or CH2;  m is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl. u
Patent FI-101539-B (FI)
Inventor: SEDERGRAN THOMAS C
IPC: A61P9/12
Filed: 1991-01-16
Granted: 1998-07-15
Abstract: An increase in the diastereoselectivity resulting from the reaction of a phosphinic acid ester of the formula <CHEM>  with the halo ester of the formula <CHEM> is achieved by carrying out the reaction in the presence of 4-methylmorpholine, diazabicyclooctane, quinuclidine, 1-methylpyrolidine, or cinchonidine. After removal of the R3 protecting group and fractional crystallization, the resulting desired diastereomeric pair can be resolved, and the desired isomer can be coupled to 4-substituted L-proline to give compounds possessing angiotensin converting enzyme inhibition activity. In particular, the process is useful in producing the antihypertensive agent fosinopril sodium in increased yields.