baber/WOPTO huggingface dataset:
Patent CR-20200314-A (CR)
Title: Suture deployment of prosthetic heart valve
Inventor: ALTMAN HERNAN
IPC: A61F2/24
Filed: 2016-12-02
Abstract: A delivery apparatus for a prosthetic implant can include an elongate first shaft, a first suture guide coupled to the first shaft, an elongate second shaft, and a second suture guide coupled to the second shaft. The first shaft can extend coaxially through the second shaft and the second suture guide, the first suture guide can be disposed distal to the second suture guide, and the first suture guide and the second suture guide can be configured to be axially movable relative to each other.
Patent CR-20210044-A (CR)
Title: Compounds and methods for reducing lrrk2 expression
Inventor: FREIER SUSAN M
IPC: C12N15/113
Filed: 2019-06-27
Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of LRRK2 RNA in a cell or animal, and in certain instances reducing the amount of LRRK2 protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least 5 one symptom or hallmark of a neurodegenerative disease. Such symptoms and hallmarks include ataxia, neuropathy, and aggregate formation. Such neurodegenerative diseases include Parkinson's disease.
Patent CR-20220431-A (CR)
Title: Gamma delta t cells and uses thereof
Inventor: SINGH SANJAYA
IPC: C12N5/0783
Filed: 2021-03-03
Abstract: Provided are methods of expanding and isolating T cells from human peripheral blood mononuclear cells (PBMCs). Also provided are isolated T cells, CAR- T cells, and methods of using the same. https://patentscope.wipo.int/search/es/detail.jsf?docId=WO2021176373&_cid=P10-L7KMGS-88202-1
Patent EC-SP034573-A (EC)
Title: Metodos para la produccion a gran escala de un tpa que se deriva de un adn recombinante o de moleculas de k2s
Inventor: WERNER ROLF GUNTHER
IPC: C12N1/21
Filed: 2003-04-29
Abstract: La presente invención pertenece al sector de la trombolisis y de la producción de derivados del activador de plasminogeno tisular (tPA) en células procarióticas. El invento se refiere a métodos para la producción de un tPA que se deriva de un ADN recombinante, una variante de este o una molécula de K2S (Kringle 2 Serina) o una variante de esta en esta en células procarióticas, en el que dicho tPA o dicha K2S o dicha variante se segrega extracelularmente como una proteína activa y correctamente plegada, la célula procariótica contiene y expresa un vector que comprende el ADN que codifica dicho tPA o dicha K2S o dicha variante, unido operativamente con el ADN que codifica el péptido de señal OmpA. El invento se refiere además a derivados específicos de K2S obtenibles por dicho método. El invento se refiere además a dichas moléculas de ADN y al uso de dichas moléculas de ADN en dichos métodos.
Patent EC-SP055936-A (EC)
Title: Bomba centrífuga con voluta configurada
Inventor: ABARCA MELO RICARDO AUGUSTO
IPC: F04D29/42
Filed: 2005-07-29
Abstract: Un forro de carcasa removible (10) en una bomba centrífuga para procesar morteros de carga pesada que contienen partículas abrasivas tiene una voluta configurada selectivamente (60) la cual es asimétrica en una sección transversal axial a lo largo de la circunferencia del forro de carcasa (10) desde la región del tajamar hasta la región de la garganta, estando dicha asimetría alrededor de un plano que disecciona radialmente la carcasa (10) y la región de la voluta (60). El forro (10) es particularmente adecuado para uso en relación con un impulsor (20) equipado con aletas expulsoras (50) para bombear mortero desde la cara del sello (62).
Patent EC-SP056066-A (EC)
Title: Un dispensador que contiene elementos piezoelectricos y su metodo de operación
Inventor: TROPEN MICK A
IPC: A61D/
Filed: 2005-09-30
Abstract: Un dispensador es provisto. El dispensador tiene un reservorio para almacenar un material líquido o sólido. El dispensador puede tener una válvula o bomba piezoeléctrica ubicada en una abertura del reservorio para la regulación de la distribución del material. Alternativamente, el dispensador puede tener una medida de gusano piezoeléctrica que empuja directa e indirectamente en contra o fuera de la abertura. La abertura puede depositar el material directa o indirectamente en la superficie de un animal, o bajo la piel del animal. El dispensador también tiene medios para ser añadido a la superficie del animal. Alternativamente, el dispensador puede ser ubicado dentro del animal.
Patent EC-SP088778-A (EC)
Title: Formulacion de un anticuerpo monoclonal humano anti-igf-1r
Inventor: MAHLER HANNS-CHRISTIAN
IPC: A61K39/395
Filed: 2008-09-26
Abstract: La presente invención está relacionada con una formulación de anticuerpo monoclonal humano anti-IGF-1R, un proceso para la preparación y usos del mismo.
Patent EC-SP930974-A (EC)
Title: Dispositivo para inyeccion de medicamento
Inventor: BACHYNSKY NICHOLAS
IPC: A61M5/32
Filed: 1993-08-20
Abstract: Un aparato para inyectar un medicamento, caracterizado porque comprende: a) un alojamiento; b) una jeringa que tiene un barril de jeringa para conservar ahí un medicamento, un émbolo movible dentro del barril para expulsar el medicamento del barril y una aguja que se comunica con el barril para transportar el medicamento desde el barril a un paciente; c) elemento de montaje para montar la aguja en el alojamiento y permitir que la jeringa se mueva desde una primera posición retraída hacia una segunda posición extendida para inyectar el medicamento, d) elemento para inyección y movimiento de la jeringa desde la primera hasta la segunda posición y empujar el émbolo para inyectar el medicamento una vez que la jeringa se haya movido cuando menos hacia la segunda posición; e) elemento de retracción para mover la jeringa nuevamente hacia la primera posición retraída después de haber inyectado el medicamento.
Patent FI-20040917-A (FI)
Inventor: LOMP GARY R
IPC: H04B17/00
Filed: 2004-07-01
Abstract: A multiple access, spread-spectrum communication system processes a plurality of information signals received by a Radio Carrier Station (RCS) over telecommunication lines for simultaneous transmission over a radio frequency (RF) channel as a code-division-multiplexed (CDM) signal to a group of Subscriber Units (SUs). The RCS receives a call request signal that corresponds to a telecommunication line information signal, and a user identification signal that identifies a user to receive the call. The RCS includes a plurality of Code Division Multiple Access (CDMA) modems, one of which provides a global pilot code signal. The modems provide message code signals synchronized to the global pilot signal. Each modem combines an information signal with a message code signal to provide a CDM processed signal. The RCS includes a system channel controller coupled to receive a remote call. An RF transmitter is connected to all of the modems to combine the CDM processed signals with the global pilot code signal to generate a CDM signal. The RF transmitter also modulates a carrier signal with the CDM signal and transmits the modulated carrier signal through an RF communication channel to the SUs. Each SU includes a CDMA modem which is also synchronized to the global pilot signal. The CDMA modem despreads the CDM signal and provides a despread information signal to the user. The system includes a closed loop power control system for maintaining a minimum system transmit power level for the RCS and the SUs, and system capacity management for maintaining a maximum number of active SUs for improved system performance. <IMAGE>
Patent GB-1014798-A (GB)
Abstract: 1,014,798. Capacitors. TOKO KABUSHIKI KAISHA. Sept. 1, 1964 [Sept. 2, 1963; Sept. 4, 1963; Dec. 4, 1963; Dec. 6, 1963], No. 35770/64. Heading H1M. A variable capacitor comprises a stationary ceramic dielectric plate with a metal electrode secured to one side thereof, a co-operating rotor including a substantially semi-circular insulator plate and a substantially semicircular metal electrode plate, and means resiliently interconnecting such plates for relative movement; the rotor assembly being urged resiliently into contact with the side of the dielectric plate opposite to the electrode and a shaft being connetted to the rotor assembly to rotate it slidably with respect to the dielectric plate. In Fig. 1, a stator S including a ceramic dielectric plate 1 is supported by member 2 and clamping plate 3; a stationary electrode 4 being printed on the rearward surface of the dielectric plate. A rotor assembly R comprises a semicircular electrode plate 5 and a semicircular insulator, of e.g. synthetic resin, with an annular member 7 interconnecting the two into a unitary circular disc mounted by spider 8 on rotary shaft 9 intersecting the stator; the dielectric and rotary discs being pressed together by cup spring 10. Plates 5, 6 are resiliently capable of relative movement, and are connected to the annular member 7 over limited areas by bonding; e.g. as shown in Fig. 6, wherein the electrode plate 5 is soldered, welded or brazed to resilient member 7 at point P, and insulator plate 6 is fitted within a window 11 of the resilient plate 7 and resiliently anchored thereto at 12, 13, while the spider 8 can urge the electrode plate 5 and insulator plate 6 against ceramic plate 7 through the windows 11, 14, 15 by uniform pressure (Fig. 7). The electrode plate may be of sintered metal particles impregnated with lubricating oil. In a modification (Figs. 8, 9) the electrode plate S is sector-shaped with a circumferential shoulder 20 to fit a sector-shaped window 22 of the insulator plate; the electrode being resiliently interconnected to the insulator at one point P while both electrode and insulator are apertured at 23 to receive the ends of resilient spider 8. Other forms of sector-shaped electrode plates resiliently interconnected with insulator plates to form circular composite rotors are described (Figs. 10-13, not shown).
Patent GB-1050999-A (GB)
IPC: H01R33/76
Abstract: 1,050,999. Valve holders. UNITED-CABR Inc. Aug. 4, 1964 [Aug. 23, 1963], No. 31417/64. Heading H2E. A resilient electrically and heat conductive saddle, for earthing and conducting heat away from the outer metal casing of a valve, has an annular portion 45 having a number of spaced portions 65-68 of C-shaped section, which extend from the top of the first portion and are each subdivided into a plurality of non-radially extending resilient fingers, e.g. 83-85, adapted to engage the valve casing. The saddle is located on chassis 21 by different sized lugs 57 and 58 and on the valve socket by a pair of lugs 48 which are curled under shoulders 40, these two pairs of lugs polarizing the socket or socket and saddle assembly within the chassis. Two further lugs 54 and 55 of the saddle make contact with two dependent lugs of the valve. The fingers, e.g. 83-85, have inwardly projecting dimples 99 to ensure good contact with the valve casing. The valve is preferably soldered to the chassis 21. In a second embodiment, there is no socket member, electrical connections being made directly to the valve pins. An inwardly directed flange is provided at the bottom of the saddle for abutting engagement by the lower edge of the metal casing of the valve. In a third embodiment, the slots between the resilient fingers are cut all the way to the annular portion 45, and the saddle is held on the chassis by bending lugs 57 and 58 outwardly.
Patent GB-1053574-A (GB)
IPC: C07C403/00
Abstract: 1,053,574. Isomerization of Vitamin A compounds. CHAS. PFIZER & CO. Inc. Aug. 4, 1964 [April 24, 1964], No. 30890/64. Heading C2V. A process for the isomerization or esterification and isomerization of a Vitamin A compound comprises contacting Vitamin A, neo- Vitamin A or a carboxylic acid ester thereof, with iodine in the presence of a basic amine at 0‹ to 115‹ C. in a solvent. The solvent may be a hydrocarbon or may be the basic amine, e.g. pyridine. After isomerization the iodine may be removed by reaction with a reducing agent, especially an alkali metal borohydride. After the isomerization the product may be esterified or transesterified, any remaining basic amine and borohydride improving the colour of the ester. Examples are given.
Patent GB-1225424-A (GB)
IPC: G01N29/30
Filed: 1968-03-28
Abstract: 1,225,424. Ultrasonic inspection devices. NIPPON KOKAN K.K. 28 March, 1968 [28 March, 1967], No. 15052/68. Heading H4D. In an ultrasonic flaw inspection system a block having an artificial flaw therein and coupled to the workpiece being inspected is used to reflect ultrasonic energy back to a transmitting/receiving probe. In an embodiment for detecting a weld flaw 14 in workpiece 9 an acrylite block 6 is coupled to the workpiece. An ultrasonic pulse is launched by directional probe 10 and returns to the probe as a flaw echo and after perpendicular reflection from an upper face of block 6. A chart record or cathoderay tube A-scan presentation of the probe signals is obtained, and the apparatus sensitivity is optimized by adjusting it so that the echo from block 6 is represented at half the amplitude of the transmitted pulse. The block reflection surface may be plane or curved and the artificial flaw, e.g. a hole or groove, is for checking the flaw detection resolution of the system (by moving probe 10 along the workpiece surface and looking for a double peak in the block echo on the A-scan presentation).
Patent GB-1225517-A (GB)
IPC: D21F1/48
Filed: 1968-04-18
Abstract: 1,225,517. Paper-making machines. BELOIT CORP. 18 April, 1968 [26 May, 1967], No. 18332/68. Heading D2A. A paper-making machine has means for changing the downward deflection of the forming board 12 with changes in deflection of the breast roll 11 in the cross machine direction. In Fig. 1, the board 12 has interconnected portions 13, 14, 15 provided with pins 21, 22 slideably engaged in a support frame 23 to permit vertical deflection adjustment of the board. Rows of fluid bellows 26, 27 mounted on frame 23 apply upward forces on the board and are controlled by individual variable values so that the board deflection can be controlled in the cross machine direction. A save all pan receives water from between portions 13, 14, 15. In Fig. 6, the forming board has heated and cooled fluid chambers 43 and 42 and the temperature differential between them, which is varied, causes the centre of the board to deflect downwardly with respect to the ends in the cross machine direction. The temperature differential may be obtained by supplying cool water or a refrigerant and hot water or steam to chambers 42, 43 respectively; or thermocouple elements may be used. In Fig. 7, the forming board has members 60, 61, 62 provided with individual interconnected tanks 63, 64, 65, each tank being provided with baffles 68 with openings 69. The board deflection is controlled in the cross machine direction by changing the quantity of water in the tanks.
Patent GB-1229916-A (GB)
IPC: A01C7/08
Filed: 1967-09-30
Abstract: 1,229,916. Seed sowing machine. NATIONAL RESEARCH DEVELOPMENT CORP. 27 Sept., 1968 [30 Sept., 1967], No. 44633/67. Heading A1D. A seed drill has a hopper and mechanically driven feeding means embodied in one unit A, separable from a coulter assembly and feeding shoots forming another unit B. The units may be secured together at end plates 11, 25 or the deposition unit A may be used separately, e.g. for grass seeding, and carries attachments (14), (16) for a three point power linkage, Fig. 2 (not shown). The seed is fed from an aperture extending across the base of a hopper 17 through resilient feed rollers 24, coupled via gear box (19) to a tractor power output, into a trough 32 and ducts 33 to coulter discs 29. The working depth of the coulters, which may take other forms, is variable via arm 34 carried by the wheel axles, pivoted at 35 to plate 25 and secured at 34 in alternative holes 36.
Patent GB-1230647-A (GB)
IPC: G06F9/302
Filed: 1968-07-11
Abstract: 1,230,647. Data processing. GENERAL ELECTRIC CO. 11 July, 1968 [14 July, 1967], No. 33075/68. Heading G4A. A data processing system includes an arithmetic unit having temporary storage means a portion of which retains a part of an information item being operated on during a first time period of an instruction execution on the item, and the same portion, during a second time period of the instruction execution, retains a count indicative of a number of repetitive operations to be performed, the count being modified during the second time period. Floating-point multiplication.-The magnitudes of the multiplicand and multiplier exponents are added or subtracted (complemented addition) according to their signs using the exponent portion of a parallel adder fed from first and second registers holding the multiplicand and multiplier respectively, the exponent result being placed in the exponent portion of the second register. The multiplier mantissa is transferred to a third register and then shifted out as successive groups of multiplier mantissa bits are examined to control build-up of a partial product with shift in the second and third registers by successive additions and subtractions (complemented addition) of the multiplicand mantissa using the mantissa portion of the adder, according to a known algorithm involving detection in the multiplier of strings of 0s and ls and single included 0s in strings of 1s and minimizing the number of additions and subtractions required. Reverse shifts by one bit are sometimes used. The partial product is separated from the multiplier by two dummy bits 00. The mantissa calculation ceases when a control count, preset into the exponent portion of the first register using the exponent portion of the adder, complemented, and then successively incremented as shifting out of the multiplier proceeds, reaches its maximum value. The incrementing is done using the exponent portion of the adder, different-sized increments being used. Other features.-Instruction retrieval and address modification overlap execution of the preceding instruction. The control count is also used to specify the number of bit positions to be shifted during floating point shift instructions and to control the number of quotient bits generated in division.
Patent GB-1231315-A (GB)
IPC: G01R31/72
Filed: 1969-07-28
Abstract: 1,231,315. Making electrical coils. REYNOLDS METALS CO. 28 July, 1969 [5 Aug., 19681, No. 37863/69. Heading B3A. An apparatus for testing and blocking, i.e. bonding together adjacent turns of a strip conductor coil 21 comprises a fixture 32 having means for supporting and locking the coil in position, an electrical device for determining the coil characteristics, and a programmer interconnecting the coil, the electrical device and the locking means. The coil 21 is placed on the mandrel 33 and a standard coil 51 of the desired impedance is placed on a mandrel 50, both coils being connected to a comparison bridge circuit (35), Fig. 3 (not shown). The programmer (40) initially actuates the mandrel 33, which is expansible within the bore 23 of the coil 21, and then provides the first test to compare theimpedances of the coils 21, 51. Should the impedance of the coil 21 not fall within the required limits, the programmer automatically stops the operation and holds the coil 21 locked on the mandrel 33. This condition is indicated visually to the operator, who unlocks the mandrel, thereby re-setting the apparatus, and removes the defective coil. If the coil impedance is satisfactory, the programmer disconnects the bridge (35) and automatically causes a high current from a variable source (36), Fig. 3, to pass through the coil. When blocking is complete, the high current flow is stopped and the programmer unlocks the mandrel 33. The current is indicated on an ammeter 62, which is provided with adjustable high and low value setting contacts (62B), (62A) respectively, Fig. 3. Should the coil go defective during blocking and the current lie outside the range of the contacts (62A), (62B), the source (36) will be disconnected from the coil 21 and visual indication of this condition supplied to the operator. The defective coil remains locked on the mandrel until released by the operator. As a safety precaution, current can only be supplied to the coil 21 if there is sufficient air pressure energizing the mandrel locking actuator 41. As a further safety feature, switches 80, 81 must be pressed simultaneously to start the programmer, thereby ensuring the operator's hands are in a safe location.
Patent GB-1234237-A (GB)
IPC: G01S15/42
Filed: 1968-12-20
Abstract: 1,234,237. Sonar systems. SMITHS INDUSTRIES Ltd. 12 Dec., 1969 [20 Dec., 1968], No. 60652/68. Addition to 1,156,322. Heading H4D. The sonar apparatus of the parent Specification 1,156,322 (Division H4) is provided with fewer reception channels than transducers and it is arranged that the particular combination of transducers coupled respectively to the channels is variable selectively. In the Fig. 1 embodiment the transducers 1 are arranged in a 20 x 20 array and twenty adjacent transducers at a time (e.g. a row, a column or a 5 x 4 group) are coupled to twenty transmission/ reception channels 5 via gating unit 4 under the control of unit 7. This enables the whole or any part of a given conical volume to be covered as desired. Unit 7 may be a manual control or may include, e.g. a gyroscope or pendulum for stabilizing the transmission/ reception direction against rolling, pitching and/or yawing of a ship carrying the sonar. Transmission, reception and display are generally as in the parent Specification, with transducers 1 being pulsed concurrently, sequentially or with different carrier frequencies, or energized with continuous wave signals. If a twodimensional array of transducers is selected, range-gating can be used to give a two-dimensional display of targets lying in a plane at a selected range. This display can be extended to a three-dimensional one by varying the range gate, or to a two-dimensional one of targets in a slant plane by using progressively different range gates for the different channels. Transmission may be effected by a separate transducer from transducers 1, channels 5 being used for reception only.
Patent GB-1234366-A (GB)
IPC: B25B27/00
Filed: 1969-06-09
Abstract: 1,234,366. Clip assembling tool. WARREN FASTENER CORP. 9 June, 1969 [10 June, 1968], No. 29016/69. Heading B4W. [Also in Division B3] A tool for pushing a clip C, Fig. 5, on to a stud S secured to a member M and projecting through a plate P, consequently securing the plate P to the member M, comprises a jaw 26, having a recess 44 to engage an up-turned rear edge F of the clip, pivoted to a barrel 22 having a stud engaging recess 36. The clip, Fig. 5, has a slot with edges E, which cut into the sides of the stud S when the clip is pushed on the stud. The jaw 26 has a cam surface 30 which engages a surface 32 at the end of a rod 18 extending from a piston 8 with enlarged end portions 10, 12 each having sealing rings 14. The portion 12 is larger than the portion 10; consequently when compressed air is introduced through a valve (not shown) actuated by a trigger 54, into the space between the end portions 10, 12, the piston moves backwards, air being expelled from behind the portion 12, through a port 50 controlled by a valve. When the piston is retracted a spring 42 causes the jaw 26 to pivot open. The up-turned end F of the clip C is now engaged in the recess 44, this being facilitated by a magnet 46, and the clip transferred to the stud S which is engaged in the recess 36, and this may also be facilitated by a magnet. The stud being engaged in an enlarged port L of the slot in the clip C, the trigger is pressed, switching the valve and causing compressed air to flow in through the port 50 to behind the end portion 12. The piston is thus driven forwards, the air in front of the end portion 12 escaping through a port 48. The surface 32 hence engages the cam surface 30 of the jaw 26, Fig. 2 (not shown), closing the jaw and hence forcing the edges E of the clip into the sides of the stud S.