Patent SG-11201811023U-A (SG)
Title: Small molecule modulators of pantothenate kinases
Inventor: SHARMA LALIT
IPC: C07H19/06
Filed: 2017-06-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H111111111111111111111111111111111111111111111100111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/223474 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: Bartlett, TN 38135 (US). JACKOWSKI, Suzanne; 6412 A01N 43/04 (2006.01) CO7H 19/06 (2006.01) Grassy Knoll Cove, Bartlett, TN 38135 (US). YUN, Mi, CO7D 513/04 (2006.01) Kyung; 1230 Mintmere Drive, Collierville, TN 38017 (US). SUBRAMANIAN, Chitra; 345 N. Ericson Drive, Cordo- (21) International Application Number: va, TN 38018 (US). LIU, Jiuyu; 1017 Stanhope Rd, Col- PCT/US2017/039037 lierville, TN 38017 (US). (22) International Filing Date: (74) Agent: SHORTELL, D., Brian et al.; Ballard Spahr LLP, 23 June 2017 (23.06.2017) 999 Peachtree Street, Suite 1000, Atlanta, GA 30309 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/354,012 23 June 2016 (23.06.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, (71) Applicant: ST. JUDE CHILDREN'S RESEARCH HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, HOSPITAL [US/US]; 262 Danny Thomas Place, Mem- KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, phis, TN 38105 (US). MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (72) Inventors: SHARMA, Lalit, Kumar; 100 Mclellan Dr., SC, SD, SE, SG, SK, SL, 5M, ST, 5V, 5Y, TH, TJ, TM, TN, Apt 1076, South San Francisco, CA 94080 (US). LEE, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — Richard, E.; 8233 Byre Hollow Cove, Cordova, TN 38018 (US). ROCK, Charles, 0.; 6412 Grassy Knoll Cove, — = Title: SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES (54) = = = = = = = = = K = 0.39 ± 0.0311 = = = = = = = .5t.5 .0 2.6 _ [Compound 7r IN FIG. I ii- en ei \" (57) : The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treat- ment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurode- generation), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning 0 tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. ei o [Continued on next page] WO 2017/223474 Al 0 111 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))