Patent GB-814483-A (GB)
Title: Improvements in or relating to antiseptic compositions
Inventor: NOEL DARWIN R
IPC: C11D3/48
Filed: 1956-09-26
Abstract: An antiseptic detergent composition comprises (1) soap or an anionic-type synthetic detergent, and (2) a synergistic combination of (a) a halogenated bisphenol of the formula <FORM:0814483/III/1> wherein X is a halogen, n is 1-3 and R is an alkylene radical of 1-4 carbon atoms or divalent sulphur, and (b) a polyhalo-salicylanilide compound of the formula <FORM:0814483/III/2> wherein Q represents hydrogen, chlorine, bromine or iodine, X1 and X2 each represent hydrogen, chlorine, bromine, iodine or CH3, X3 represents hydrogen, chlorine, bromine or CF3, and X4 and Y each represent hydrogen, chlorine or bromine, at least 3 halogen substituents being present in the X positions.  The term "soap" refers to the water-soluble ammonium, metallic or organic base salts of various fatty acids, which are chiefly lauric, oleic, stearic and palmitic acids, and covers all products in which soap is a major constituent, for example bar, flake, powdered, soft and liquid soaps, and shaving creams, tooth pastes and cleansing creams. Specified detergents are the alkylaryl sulphonates, such as sodium or potassium dodecyl benzene sulphonate, sodium or potassium octadecyl benzene sulphonate, and sodium or potassium octyl naphthalene sulphonate; the alkylsulphates, such as sodium or potassium salts of dodecyl, hexadecyl, and octadecyl sulphates; the sulphonated fatty acid amides, such as sodium or potassium salts of the oleic acid amide of methyl taurine; and the sulphonated monoglycerides, such as the monococonut oil fatty acid ester of 1,2-hydroxypropane-3-sodium sulphonate.  Reference has been directed by the Comptroller to Specifications 722,590, 745,607 and 755,140, [all in Group VI].ALSO:An antiseptic composition contains as its essential active ingredients a synergistic combination of a halogenated bisphenol having the general formula <FORM:0814483/VI/1> wherein X is a halogen, n is an integer of from 1 to 3 and R is an alkylene radical having from 1 to 4 carbon atoms or divalent sulphur and a polyhalo-salicylanilide compound represented by the general formula <FORM:0814483/VI/2> wherein Q represents hydrogen, chlorine, bromine or iodine, X1 and X2 each represent hydrogen, chlorine, bromine or iodine, and CH3, X3 represents hydrogen, chlorine, bromine or CF3, and X4 and Y each represent hydrogen, chlorine or bromine, at least 3 halogen substituents being present in the X positions, preferably in proportion of 0.1 to 3 per cent of the former and 3 to 0.1 per cent of the latter.  Soap may be included to produce shaving creams, toothpastes and cleansing creams. Specified bisphenols are 2,21 - dihydroxy - 3,5,6,31,51, 61-hexachlorodiphenyl methane, 2,21-dihydroxy-3,5,31,51 - tetrachlorodiphenyl methane, 2,21-dihydroxy - 4,5,41,51 - tetrachlorodiphenyl methane, 2,21 - dihydroxy - 3,4,31,41 - tetrachlorodiphenyl methane, 2,21-dihydroxy-5,51-dibromodiphenyl methane, 2,21 - dihydroxy - 3,5,31,51 - tetrachlorodiphenyl sulphide and 2,21 - dihydroxy - 5,51 - dichlorodiphenyl sulphide.  Specified salicylanilides are 5-chlorosalicylic acid - 31,41 - dichloroanilide, 4,5 - dichlorosalicylic acid - 21,31,41 - trichloroanilide, 5 - chlorosalicylic acid - 21,31,41 - trichloroanilide, and 3,5-dichlorosalicylic acid-21,31,41-trichloroanilide.  Reference has been directed by the Comptroller to Specifications 722,590, 745,607 and 755,140.