baber/WOPTO huggingface dataset:
Patent AU-2002352052-A1 (AU)
Title: 2-aryl-propionic acids and pharmaceutical compositions containing them
Inventor: ALLEGRETTI MARCELLO
IPC: C07C317/44
Filed: 2002-11-19
Abstract: (R,S)-2-Aryl-propionic acids are useful as inhibitors of interleukin-8 induced human polymorphonucleated neutrophils (PMN) chemotaxis. (R,S)-2-Aryl-propionic acids of formula (I), their single (R) and (S) enantiomers or salts are useful as inhibitors of interleukin-8 (IL-8) induced human polymorphonucleated neutrophils (PMN) chemotaxis. [Image] Ar : phenyl ring (substituted by T in meta position, T 1 in para position or T 2 in ortho position); T : linear or branched 1-5C alkyl, 2-5C alkenyl, or 2-5C alkynyl (optionally substituted by 1-5C alkoxycarbonyl, optionally substituted phenyl, linear or branched 1-5C hydroxyalkyl or arylhydroxymethyl); T 1benzoyloxy, benzoylamino, benzenesulfonyloxy, benzenesulfonylamino, benzenesulfonylmethyl (all optionally substituted), 1-5C acyloxy, 1-5C acylamino, 1-5C sulfonyloxy, 1-5C alkanesulfonylamino, 1-5C alkanesulfonylmethyl, 3-6C cycloalkyl, 2-furyl, 3-tetrahydrofuryl, 2- thiophenyl, 2-tetrahydrothiophenyl or ((1-8C)-alkanoyl, -cycloalkanoyl or -arylalkanoyl)-1-5C-alkylamino (preferably acetyl-N-methyl-amino or pivaloyl-N-ethyl-amino); and T 2arylmethyl, aryloxy or acylamino (all optionally substituted by 1-4C alkyl, 1-4C-alkoxy, chlorine, fluorine or trifluoromethyl). The meta linear or branched 1-5C alkyl together with a substituent in ortho or para position and the benzene ring forms optionally saturated or optionally substituted bicyclo aryls. INDEPENDENT CLAIM are included for the following: (1) preparation of (I); and (2) use of (I) in the preparation of a medicament for the treatment of e.g. psoriasis, ulcerative colitis, melanoma and chronic obstructive pulmonary disease (COPD). ACTIVITY : Antipsoriatic; Antiulcer; Respiratory-Gen.; Antirheumatic; Antiarthritic; Nephrotropic; Vasotropic; Antiinflammatory; Gastrointestinal-Gen.; Cytostatic. MECHANISM OF ACTION : Interleukin-8 (IL-8) inhibitor; GROalpha inhibitor; CXCR2 agonist/antagonist. The ability of (R,S) 2-[(3'-isopropyl)phenyl]propionic acid (A) to inhibit IL-8 induced chemotaxis of human monocytes was tested as described in Van Damme J. et al. (Eur. J. Immunol., 19, 2367, 1989). (A) showed inhibition (%) of 51+-12.
Patent AU-2002365437-A1 (AU)
Title: Methods and compositions for inducing an immune response
Inventor: WEI ZHENG
IPC: A61K48/00
Filed: 2002-10-21
Abstract: The inventors have discovered that a CKbeta8-1 truncation variant, CKbeta8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKbeta8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKbeta8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKbeta8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
Patent AU-2003201025-A1 (AU)
Title: Process for preparing chain extended thermoplastic guanidinium polymers
Inventor: HALL DENISE
IPC: C09D11/00
Filed: 2003-01-06
Abstract: A process for forming a chain extended thermoplastic polymer which includes reacting: (i) a prepolymer having one or more guanidinium or biguanidinium units and having at least one reactive end group; and (ii) a chain extender having at least two groups able to react with reactive end group(s) in (i). The polymer used as fixing agent to reduce highlighter smear of prints prepared by ink jet printing.
Patent AU-2003209636-A1 (AU)
Title: Novel chemokine binding peptides capable of modulating the biological activity of chemokines
Inventor: PELED AMNON
IPC: A61K38/08
Filed: 2003-02-27
Abstract: The present invention relates to novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences which characterize the families or categories of these modulator peptides.
Patent AU-2003210117-A1 (AU)
Title: Conditioner
Inventor: HERMSMEYER ANDREA
IPC: A23L5/10
Filed: 2003-03-26
Abstract: The conditioner, to process animal fodder and human foodstuffs by a mixer with a dwell time for thermal or hydrothermal treatment, has at least one lower dwell unit (4) under the mixer (3) and an upper material dosing feed (2). The dwell unit and the mixer have identical end plates (5,6), which are linked together at least at one end. Hot air is fed into the dwell unit as steam during the dwell time.
Patent AU-2003210569-A1 (AU)
Title: Intervertebral disk prosthesis
Inventor: ECKMAN WALTER W
IPC: A61F2/30
Filed: 2003-01-17
Abstract: A method of using an intervertebral disk prosthesis includes the step of ensuring that the intervertebral space between first and second vertebrae of a patient is substantially free of nuclear matter. The method also includes the step of inserting a distal end of the disk prosthesis into a gap between the first and second vertebrae. The disk prosthesis includes a first part with a convexly-shaped and rounded outer surface and an inner surface having a concavely-shaped socket. The disk prosthesis also includes a second part that has a convexly-shaped and rounded outer surface and an inner surface that has a convexly-shaped portion that at least partially engages with the socket thereby allowing at least two-degrees of freedom of movement of the first part with respect to the second part. The method further includes the step of permitting the top of the first part to contact the first vertebra and the bottom of the second part to contact the second vertebra.
Patent AU-2003217109-A1 (AU)
Title: Sluice feeder
Inventor: OBITZ LARS
IPC: F16K3/04
Filed: 2003-03-04
Abstract: The invention concerns a sluice feeder comprising an inlet ( 1 ), an outlet ( 11 ), and a rotor ( 2 ), into which sluice feeder material to be fed from a first medium to a second medium sealed from the first medium is fed to the inlet ( 1 ). The inlet ( 1 ) is directed towards the centre portion of the rotor ( 2 ), the rotor ( 2 ) and a cooperating stator ( 7 ), respectively, show at least a radial opening ( 5, 8 ) each and are provided so that at least one pocket ( 9 ) is formed, which alternating opens and seals upon rotation of the rotor ( 2 ). The material is thrown radially outwards by the rotor ( 2 ) to the pocket ( 9 ) to finally be emptied from the pocket ( 9 ) to the outlet at the same time as the pocket ( 9 ) is sealed towards the inlet ( 1 ) by means of the stator ( 7 ).
Patent AU-2003218400-A1 (AU)
Title: Fuel injector for an internal combustion engine
Inventor: PELLIZZARI ROBERT O
IPC: F02M53/06
Filed: 2003-03-24
Abstract: A fuel injector for vaporizing a liquid fuel for use in an internal combustion engine. The fuel injector includes at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end, a fluid control valve for placing the inlet end of the at least one capillary flow passage in fluid communication with the liquid fuel source and introducing the liquid fuel in a substantially liquid state, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat the liquid fuel in the at least one capillary flow passage to a level sufficient to change at least a portion thereof from the liquid state to a vapor state and deliver a stream of substantially vaporized fuel from the outlet end of the at least one capillary flow passage and means for cleaning deposits formed during operation of the apparatus. The fuel injector is effective in reducing cold-start and warm-up emissions of an internal combustion engine. Efficient combustion is promoted by forming an aerosol of fine droplet size when the substantially vaporized fuel condenses in air.
Patent AU-2003219365-A1 (AU)
Title: Method of inventorizing a plurality of data carriers
Inventor: AMTMANN FRANZ
IPC: G06K19/07
Filed: 2003-04-09
Abstract: In a method of inventorizing a plurality of data carriers (2) with the aid of a communication station (1) communicating in a contact-free way with the data carriers (2), a set (TS(1), TS(2), . . . TS(N), TS(N+1), . . . (TS(K)) of transmission parameters, preferably of time slots (TS) is available, which set comprises a first subset (TS(1) . . . TS(N)) and a second subset (TS(N+1) . . . (TS(K)) wherein inventorizing procedures (MP1, MP2, MP3, . . . ) are performed consecutively and wherein uninventorized data carriers (2) transmit their identification data (ID) to the communication station (1) for the purpose of inventorization only using transmission parameters contained in the first subset and wherein already inventorized data carriers (2) transmit their identification data (ID) to the communication station (1) only using transmission parameters contained in the second subset.
Patent AU-2003222081-A1 (AU)
Title: Electrical terminal for surge protection cartridge
Inventor: BAUM THOMAS
IPC: H01R11/22
Filed: 2003-03-26
Abstract: An electrical terminal and a system of the terminal and a housing is disclosed as an example of the present invention. The electrical terminal and the housing have a number of advantages including being sufficiently stiff to prevent arcing and physical damage to the electrical terminal upon being exposed to surge current/voltage. The terminal includes a contact with a base portion from which two spaced apart arms extend outwardly. First portions of the arms are generally parallel to one another. Second portions of the arms converge toward each other and then flare outwardly along third portions of the arms. At the junction of the second and third portions, there is a contact region formed to receive the lead of a surge protection device. The tenminal is enclosed in an opening in the electrically insulative housing, the opening being bordered by walls closely adjacent to the first portions of the arms. The spacing of the walls from the arms is about 0.001 inches on each side of the terminal. When the tenminal is exposed to a surge current/voltage, the walls stiffen the tenminal and prevent arcing and physical damage.
Patent AU-2003237285-A1 (AU)
Title: Hydraulic dampers with pressure regulated control valve and remote pressure adjustment
Inventor: TURNER ROY A
IPC: F16F9/06
Filed: 2003-05-29
Abstract: A suspension damper includes a housing bounding a main chamber. A hydraulic fluid is disposed within the main chamber. A piston rod is selectively movable between an advanced position wherein a portion of the piston rod is advanced into the main chamber and a retracted position wherein the portion of the piston rod is retracted from the main chamber, wherein as the piston rod is moved a fluid pressure of the hydraulic fluid within the main chamber progressively increases and a portion of the hydraulic fluid passes through a passage within the housing. A control valve is at least partially disposed within the main chamber, the control valve being moved by the fluid pressure of the hydraulic fluid so as to progressively restrict the flow of the hydraulic fluid through the passage as the fluid pressure of the hydraulic fluid within the main chamber progressively increases.
Patent AU-2003238172-A1 (AU)
Title: Forming jaw for producing a succession of sealed packages from a tube of sheet packaging material
Inventor: ORSINI IVAN
IPC: B65B51/30
Filed: 2003-05-29
Abstract: A forming jaw for producing a succession of sealed packages from a tube of sheet packaging material filled with a pourable food product and fed in a direction parallel to its longitudinal axis is disclosed. The jaw includes sealing structure that seals a cross section of the tube; and forming structure that imparts a predetermined shape to the tube between two successive sealed cross sections. The forming structure has first and second surfaces for interacting with the tube and which extend respectively in a direction crosswise to, and in a direction parallel to, the axis of the tube. The first surface has a convex portion which exerts pressure on, to control filling of, the packages being formed.
Patent AU-2003240148-A1 (AU)
Title: A mobile device for displaying information content
Inventor: BALLE HENRIK
IPC: G06F3/023
Filed: 2003-04-25
Abstract: A device, comprising: a display, having a display area, for displaying information content; a user input device; and a processor, for controlling the display, arranged to incrementally change the size of the display area while displaying the information content, in response to successive inputs from the user input device.
Patent AU-2003246965-A1 (AU)
Title: Production of polyketides
Inventor: GREGORY MATTHEW ALAN
IPC: C12N15/52
Filed: 2003-07-16
Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
Patent AU-2003254749-A1 (AU)
Title: Hyperpolarized noble gas extraction methods, masking methods, and associated transport containers
Inventor: DRIEHUYS BASTIAAN
IPC: A61B5/055
Filed: 2003-10-16
Abstract: Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.
Patent AU-2003280067-A1 (AU)
Title: Instruments and methods for minimally invasive tissue retraction and surgery
Inventor: FOLEY KEVIN T
IPC: A61B17/34
Filed: 2003-06-20
Abstract: Methods and devices retract tissue for minimally invasive surgery in a patient. A retractor (20) includes a working channel (50) formed by a first portion (22) and a second portion (42). The first and second portions are movable relative to one another from a first configuration for insertion that minimizes trauma to skin and tissue to an enlarged configuration after insertion to further retract skin and tissue in a minimally invasive manner. Instruments are engageable to the first and second portions and operable to move the first and second portions relative to one another.
Patent AU-2003285733-A1 (AU)
Title: A measuring cell
Inventor: DAVID TSUR BEN
IPC: G01N1/38
Filed: 2003-12-08
Abstract: The invention relates to a spectrophotometric measuring cell, useful for automated reagent mixing and for handsfree physical cleansing comprising: a measuring cell; a shaker; and an actuator. The invention also relates to a method for automatically mixing of fluids and/or reagents and for handsfree physical cleansing of the inner core of spectrophotometric measuring cells.
Patent AU-2003298116-A1 (AU)
Title: Condenser
Inventor: BECKER CHRISTIAN
IPC: F25B39/04
Filed: 2003-11-14
Abstract: The device consists of a block of pipes and ribs, collection pipes on both sides, whereby at least one collection pipe has a floor holding the ends of the pipes and a top, and a collector parallel to a collection pipe with a fluid connection to the pipe via connection openings and consisting of a pipe and short profile piece (14) with the connection openings. The profile piece has a first part (16) of the top formed on it.
Patent AU-2003298311-A1 (AU)
Title: Process for the synthesis of cycloorganylphosphanes and di(alkali metal/alkaline earth metal) oligophosphanediides
Inventor: GRUTZMACHER HANSJORG
IPC: C07F9/6596
Filed: 2003-11-24
Abstract: The invention relates to a process for the preparation of cycloorganylphosphanes of formula 1 (R<SUP>1</SUP>P)<SUB>n </SUB>by reaction of dihalo(organyl)phosphanes of formula R<SUP>1</SUP>PHal<SUB>2 </SUB>with: a) activated zinc in an organic solvent, or with: b) an alkali metal or alkaline earth metal in a non-polar organic solvent in the presence of an activator, wherein R<SUP>1 </SUP>is C<SUB>1</SUB>-C<SUB>12</SUB>alkyl; C<SUB>3</SUB>-C<SUB>12 </SUB>cycloalkyl, aryl or heteroaryl, Hal is F, Cl, Br or I, and n is a number from 3 to 20. The invention relates also to novel di(alkali metal/alkaline earth metal) oligophosphanediides and to the use thereof in the preparation of organophosphorus compounds.
Patent AU-2003303237-A1 (AU)
Title: Human monoclonal antibodies to epidermal growth factor receptor (egfr)
Inventor: WINKEL JAN G J VAN DE
IPC: A61K39/00
Filed: 2003-12-16
Abstract: Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Patent WO-2004107984-A1 (WO)
Title: Aiguille servant a prelever un tissu
Inventor: BUNCE PHILIP
IPC: A61B17/34
Filed: 2004-06-03
Abstract: Aiguille servant à prélever un tissu et présentant un corps creux tubulaire (20) dont la pointe est définie par une face d'extrémité concave (23).
Patent AU-2004292337-A1 (AU)
Title: Methods and apparatus for the systemic control of ventilatory support in the presence of respiratory insufficiency
Inventor: BASSIN DAVID JOHN
IPC: A61M16/06
Filed: 2004-11-25
Abstract: There is provided apparatus for providing ventilatory assistance to a spontaneously breathing patient comprising: 
processing means (15) for computing a measure of the difference between a function of respiratory airflow and a target value, and 
a control mechanism (15) for causing a blower (2) to deliver air to the patient at a pressure that is a function of said difference measure, the control mechanism (15) using a blower (2) in a servo-controlled loop whose gain varies depending on the magnitude of said difference measure.
Patent AU-2004296256-A1 (AU)
Title: Silver chain manufacture
Inventor: JOHNS PETER GAMON
IPC: B21L3/00
Filed: 2004-12-09
Abstract: A method for silver chain manufacture comprises forming lengths of silver wire into successive chain links whose ends abut using an automatic chain forming machine, and closing the links by brazing or welding abutting ends thereof, by means or a laser. The wire comprises at least 92.5 wt % Ag and about 0.5aboul 3 wt % Gc and speeds of 100-250 links per minute can be achieved. The invention also relates to a silver chain.
Patent AU-2004308422-A1 (AU)
Title: Dynamic cervical plates and cervical plate constructs
Inventor: MILLELA MICHAEL J JR
IPC: A61B17/56
Filed: 2004-12-22
Abstract: N-level internally dynamizing cervical plates and cervical plate constructs in accordance with the present principles, provide unconstrained sliding interconnection between the various plate components after installation on a cervical spine. A tongueand-groove configuration between the various plate segments provides a constant thickness over the dynamizing portions. Detents provided relative the tongue-andgroove portions allows the various plate components to be permanently joined, but movable relative to one another. Various bone screw anti-backing, anti-rotation or locking devices for cervical bone plates are also provided that allow releasable locking of bone screws relative to the cervical plate.
Patent AU-2005243453-A1 (AU)
Title: Method of fabricating a helical two-dimensional fiber sheet
Inventor: DELECROIX VINCENT
IPC: D04H1/498
Filed: 2005-04-20
Abstract: A transverse fiber sheet is lapped by being guided in a substantially radial direction back and forth along a path between circumferentially outer and inner edges of the sheet, with the transverse sheet being reversed at each end of its path, the width of the transverse sheet being narrowed between the outer circumferential edge and the inner circumferential edge, the transverse sheet being held in place as it is lapped. Substantially mutually parallel yarns or tows are pulled to form a helical longitudinal sheet of density per unit area that decreases between its outer edge and its inner edge. The transverse sheet and the helical longitudinal sheet are superposed and advance continuously in flat rotation, and they are assembled together to form a helical sheet which is removed.
Patent AU-2005263823-A1 (AU)
Title: Method and device for accelerating the growth of skin appendages, in particular nails
Inventor: MILLET JEAN-CLAUDE
IPC: A61F13/06
Filed: 2005-06-17
Abstract: A method and a device are provided for accelerating the growth of skin appendages. According to one embodiment, a dressing is provided having an enveloping fabric and a lining material designed to be in contact with at least one appendage, and a liquid or viscous base containing water in a proportion sufficient for maintaining a high degree of moisture near the appendage. The liquid or viscous base is deposited on the lining material of the dressing, and the dressing is placed in such a way that the lining material is in contact with the appendage.