Patent GB-588298-A (GB)
Title: Improvements in or relating to vitamin compositions
IPC: A61K31/59
Filed: 1944-08-16
Abstract: Vitamin containg compositions which are miscible with water in all proportions are prepared by dissolving a lipoid soluble, normally water - insoluble and substantially fat - free material in a solubilizing agent comprising a polyalkylene oxide derivative of a partial fatty acid ester of a polyhydric alcohol, the fatty acid radical of which contains at least 12 carbon atoms.  The preferred solubilizing agent is an ethylene oxide derivative of a mono fatty acid ester of a polyhydric alcohol wherein the number of ethylene oxide groups to the molecule is between 16 and 25. The preferred polyhydric alcohol is sorbitol, which is usually used in the form of its anhydride sorbiton.  Compounds mentioned as solubilizing agents include the polyethylene oxide derivatives of sorbiton monolaurate, monopalmitate, monostearate and monooleate, also the complex monostearate of propylene glycol with 25 mols. of ethylene oxide and the like complex monooleate ester of ethylene glycol with 20 mols. of propylene oxide.  The invention is particularly adapted to produce solutions of vitamins A and D.  The compositions of the invention when dissolved in water may be admixed with other water-soluble vitamins and used as an addition for milk, soup, fruit juice or beverages.  Additional agents specified include thiamine, riboflavin, pyridoxine, ascorbic acid, nicotinic acid, vitamin E and vitamin K. In examples, sorbiton monolaurate (ethylene oxide) 20 is added to (1) a vitamin A concentrate from a fish oil, (2) crystalline vitamin A alcohol, (3) irradiated ergosterol resin, (4) a mixture of vitamin A and D concentrates from fish oil, and alpha - tocopherol.  In addition, the solubilization of a vitamin A concentrate with sorbiton monooleate (ethylene oxide) 20 and propylene glycol monostearate (ethylene oxide) 20 is described.ALSO:Vitamin containing compositions which are miscible with water in all proportions are prepared by dissolving a lipoid soluble, normally water insoluble and substantially fat free material in a solubilizing agent comprising a polyalkylene oxide derivative of a partial fatty acid ester of a polyhydric alcohol the fatty acid radical of which contains at least 12 carbon atoms.  The preferred solubilizing agent is an ethylene oxide derivative of a mono fatty acid ester of a polyhydric alcohol wherein the number of ethylene oxide groups to the molecule is between 16 and 25.  The preferred polyhydric alcohol is sorbitol, which is usually used in the form of its anhydride sorbiton. Compounds mentioned as solubilizing agents include the polyethylene oxide derivatives of sorbiton monolaurate, monopalmitate, monostearate, and monooleate, also the complex monostearate of propylene glycol with 25 mols of ethylene oxide and the like complex mono-oleate ester of ethylene glycol with 20 mols of propylene oxide. The invention is particularly adapted to produce solutions of vitamins A and D. The compositions of the invention when dissolved in water may be admixed with other water soluble vitamins and used as an addition for milk, soup, fruit juice or beverages.  Additional agents specified include thiamine, riboflavin, pyridoxine, ascorbic acid, nicotinic acid, vitamin E and vitamin K.  In examples, sorbiton monolaurate (ethylene oxide) 20 is added to (1) a vitamin A concentrate from a fish oil, (2) crystalline vitamin A alcohol, (3) irradiated ergosterol resin, (4) a mixture of vitamin A and D concentrates from fish oil, and alpha-tocopherol.  In addition the solubilization of a vitamin A concentrate with sorbiton mono-oleate (ethylene oxide) 20 and propylene glycol monostearate (ethylene oxide) 20 is described.