Patent SG-11201901032P-A (SG)
Title: Elution and detection
Inventor: LYFORD GRAHAM WILLIAM
IPC: G01N33/487
Filed: 2017-08-15
Abstract: HV Drair Drain 110 Heater I Temperabsre Fan 128 126 124 / 41 ANY\ I , Sensor 1111A`.„ , , „ — , , A ...... .... • • ... — Valves anti pump control r RS422 Piston Pump —1 --1 Air Rurrip 1 Isolated C4D suPPIY I I— 150 106 BCE Elution 108A 12 108 104 116 Main R uidics block 114 118A 52 Sulk Power Supply — Mains inlet HV Rower Srrrly 56 120 142 Safety Interlock MCU and IC board 138 136 RS232 132 122 144 RS232 DEBUG 146 Figure 1 (57) : An elution apparatus and a detection apparatus are described. The elution apparatus includes: a sample trap for trapping a sample; and one or more pumps and/or valves to move a liquid eluent and a liquid eluate, wherein the eluate includes an extracted portion of the sample that is extracted by the eluent. The detection apparatus includes: a capillary having a low-voltage (LV) end portion to receive a sample; and a conductivity detector coupled to a high-voltage (HV) end portion of the capillary to generate signals based on conductivity of a monitored portion of the capillary in the HV end portion, wherein the conductivity detector is electrically isolated from the LV end portion. *!IC O O co O C \"I 150 , C4D , Detemor HV Fluidics block 140 Cap ilary I Embedded %Mildews PC w/touchscreen `134 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIP0 I PCT olimion °nolo III 1111 nit immo imiflo DIEN (10) International Publication Number WO 2018/032044 Al (51) International Patent Classification: (72) Inventors: LYFORD, Graham William. SMITH, G01N 27/447 (2006.01) BOlD 57/02 (2006.01) Michael. WEBB, Alistair Stuart. CUSICK, Adam John. G01N 27/26 (2006.01) G01N 33/487 (2006.01) RYAN, Leigh. SOHN, Ian Emil. (21) International Application Number: (74) Agent: DAVIES COLLISON CAVE; 1 Nicholson Street, PCT/AU2017/050862 Melbourne, Victoria 3000 (AU). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 15 August 2017 (15.08.2017) kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, English (26) Publication Language: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (30) Priority Data: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 15 August 2016 (15.08.2016) AU 2016903232 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 16 June 2017 (16.06.2017) AU 2017902304 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: GREYSCAN PTY LTD [AU/AU]; Level 4, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 543 Bridge Road, Richmond, Victoria 3121 (AU). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, = (54) Title: ELUTION AND DETECTION 100 Elution Chamber , 102 Sample input 1 ' [Continued on next page] WO 2018/032044 Al MIDEDIMOMMIDIRERIONIMOIDENHOHMEEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))