Patent AU-2013201406-B2 (AU)
Title: Methods for treating HCV
Inventor: BERNSTEIN BARRY M
IPC: A61K31/00
Filed: 2012-10-19
Granted: 2014-10-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/059630 Al 25 April 2013 (25.04.2013) W I PO I P CT (51) International Patent Classification: (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan A61K31/4025 (2006.01) A61K31/497 (2006.01) Road, North Chicago, Illinois 60064 (US). A61K 31/4178 (2006.01 ) A61K 31/513 (2006.01 ) A61K31/4709 (2006.01) A61K31/5377 (2006.01) (72) Inventors: BERNSTEIN, Barry M.; 10829 Wyngate A 61K 31/4725 (2006.01) A61P3114(2006.01) Trace, Mequon, Wisconsin 53092 (US). MENON, Rajeev A61K 31/4725 (2006.01) A61P 31114 (2006.01) M.; 81 Pinyon Pine Court, Buffalo Grove, Illinois 60089 (21) International Application Number: (US). KHATRI, Amit; 1360 S. White Oak Drive, Apt. PCT/US2012/061075 225, Waukegan, Illinois 60085 (US). MENSING, Sven; (22) International Filing Date: Langer Schlag 95a, 68305 Mannheim (DE). DUTTA, 19 October 2012 (19.10.2012) Sandeep; 7303 Clem Drive, Gurnee, Illinois 60031 (US). COHEN, Daniel E.; 930 Oakwood Avenue, Wilmette, (25) Filing Language: English Illinois 60091 (US). PODSADECKI, Thomas J.; 708B N. Orleans, Chicago, Illinois 60654 (US). BRUN, Scott C.; (26) Publication Language: English 31048 Prairie Ridge Road, Green Oaks, Illinois 60048 (30) Priority Data: (US). AWNI, Walid M.; 14105 Edgewater Court, Green 61/550,352 21 October 2011 (21.10.2011) US Oaks, Illinois 60048 (US). DUMAS, Emily 0.; 232 E. 61/562,181 21 November 2011 (21.11.2011) US Winchester, Libertyville, Illinois 60048 (US). KLEIN, 61/587,225 17 January 2012 (17.01.2012) US Cheri E.; 1933 Barberry Road, Northbrook, Illinois 60062 61/600,276 17 February 2012 (17.02.2012) US (US). 61/616,20 1 6 Apri 2012 (06.06.2012) us (74) Agents: ZHANG, Xu et al.; 100 Abbott Park Road, Abbott 61/711,830 10 October 2012 (10.10.2012) US ' [Continued on next page] (54) Title: METHODS FOR TREATING HCV COMPRISING AT LEAST TWO DIRECT ACTING ANTIVIRAL AGENT, RIB AVIRIN BUT NOT INTERFERON. (57) Abstract: The present invention features interfer on-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more - 150 mu QD (ompound 1-+ 400 mg BID Compotmd 2 +-25 mg QD Compund4 than 12 weeks. In one aspect, the therapies comprise ad E 250 ma QD Compound I - 400 mig BID Compund 2 +' 2ng QD Compnld 4 ministering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject ef fective amounts of therapeutic agent 1, therapeutic agent M M2 (or therapeutic agent 3), an inhibitor of cytochrome M P450 (e.g., ritonavir), and ribavirin. b 24 6 8 10 12 16 24 Time (weeks) Figure 6C WO 2013/059630 A1||1ll1l1||1ll1||1l1ll1ll1ll1ll1|||111|||||||||11|1|1|||1|1||11|||||||||D||||||111|11 |I|||| I| (81) Designated States (unless otherwise indicated, for every GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, kind of national protection available): AE, AG, AL, AM, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, GW, ML, MR, NE, SN, TD, TG). MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Published: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, - with international search report (Art. 21(3)) TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN' before the expiration of the time limit for amending the ZA, ZM, ZW. claims and to be republished in the event of receipt of (84) Designated States (unless otherwise indicated, for every amendments (Rule 48.2(h)) kind of regional protection available): ARIPO (BW, GH,