baber/WOPTO huggingface dataset:
Patent RU-2700649-C2 (RU)
Title: Genetic construct based on non-viral vector plasmid including p4na2 gene cdna for reducing manifestations of human body conditions associated with reduced expression of p4na2 gene and/or reducing amount of prolyl 4-hydroxy acid alpha 2 protein, method of producing and use
Inventor: Savelieva Natalia
IPC: A61K38/44
Filed: 2017-12-25
Granted: 2019-09-18
Abstract: FIELD: biotechnology; medicine. 
     SUBSTANCE: invention relates to molecular biology, biotechnology, genetic engineering and medicine, and can be used for relief of manifestations of human body conditions associated with reduced expression of P4NA2 gene and/or reduced amount of protein prolyl 4-hydroxy acid alpha 2. Disclosed is a genetic construct based on a non-viral DNA vector comprising a P4NA2 gene cDNA selected from genetic constructs, each of which represents a genetic construct based on a DNA vector comprising a cDNA of the P4NA2 gene, with a coding protein sequence of prolyl 4-hydroxy-oxidase alpha 2, with 5' deletions and 3'-non-translated regions, specifically obtained based on the native non-modified cDNA region of the P4NA2 gene SEQ ID No: 1 or modified cDNA of the P4NA2 gene, wherein the modified P4NA2 gene cDNA used is SEQ ID No: 2, or SEQ ID No: 3, or SEQ ID No: 4, or SEQ ID No: 5, or SEQ ID No: 6, or SEQ ID No: 7, or a combination of these genetic constructs, each of which also contains regulatory elements providing a high level of expression of the P4NA2 gene in eukaryotic cells. Method of producing a genetic construct and use thereof are also provided. 
     EFFECT: invention allows increasing the amount of prolyl 4-hydroxylase alpha 2 protein in eukaryotic cells. 
     6 cl, 28 dwg, 20 ex
Patent RU-2712196-C2 (RU)
Inventor: WESTMAN JACOB
IPC: C07D487/04
Filed: 2016-06-10
Granted: 2020-01-24
Abstract: Изобретение относится к соединению формулы (I) или его фармацевтически приемлемой соли. В формуле (I) W представляет собой CH; X представляет собой C; цикл A представляет собой фенил или 5- или 6-членный гетероарил, где указанный гетероарил содержит 1, 2, 3 или 4 гетероатома, выбранных из N, O и S; m равен целому числу от 0 до 2; каждый Rвыбирают независимо из (C1-C6)алкила, необязательно замещенного одним или несколькими атомами галогена, RO, галогена, RC(O)N(R), RS(O), RS(O)N(H),O и RRNS(O); и когда m равен по меньшей мере 2, два R, присоединенные к соседним атомам цикла A, могут образовывать, вместе с атомами, к которым они присоединены, 5- или 6-членный гетероцикл или карбоцикл; где гетероцикл содержит 1 или 2 гетероатома, выбранных из кислорода; каждый R, R, R, R, Rи Rвыбирают независимо из H и (C1-C6)алкила, при этом любой алкил необязательно замещен одним или несколькими атомами галогена; Rвыбирают из H, (C1-C6)алкила, RC(O) и ROC(O); и каждый Rи Rвыбирают независимо из H и (C1-C6)алкила, при этом любой алкил необязательно замещен одним или несколькими атомами галогена. Изобретение также относится к фармацевтической композиции, к применению соединения, к способу лечения энтеровирусной инфекции. Технический результат: получены новые соединения формулы (I), обладающие свойствами ингибитора фосфатидилинозитол-4-киназы IIIβ. 4 н. и 13 з.п. ф-лы, 5 табл., 32 пр.
Patent RU-2721776-C2 (RU)
Inventor: BIMANS Barbara
IPC: C07D487/10
Filed: 2016-07-11
Granted: 2020-05-22
Abstract: FIELD: medicine; pharmaceuticals. 
     SUBSTANCE: invention relates to a novel compound of formula I or a pharmaceutically acceptable acid addition salt or corresponding enantiomer thereof. In formula I 
     
       
     
     R 1  is lower alkyl; R 2  is phenyl or pyridinyl, wherein the N atom in the pyridinyl group can be in different positions; n equals 0, 1 or 2; V/U are independently O or CH 2 , where V and U can not be simultaneously O; L is a five- or six-membered heteroaryl group selected from 
       . 
     EFFECT: compounds have glutamate 4 metabotropic receptor activity and can be used for treating Parkinson's disease, anxiety, vomiting, obsessive-compulsive disorder, autism, cancer, depression, type 2 diabetes and neuroprotection. 
     15 cl, 1 dwg, 4 tbl, 17 ex
Patent RU-2689976-C2 (RU)
Title: Эффективный механизм отбрасывания при развертывании небольших сот
Inventor: BASU MALLICK PRATEEK
IPC: H04L47/56
Filed: 2014-07-23
Granted: 2019-05-30
Abstract: Изобретение относится к области радиосвязи. Техническим результатом является повышение эффективности отбрасывания данных нисходящей линии связи, предназначенных для мобильной станции, присоединенной как к ведущей базовой станции, так и ко вторичной базовой станции. Ведущая базовая станция конфигурирует вторичную функцию отбрасывания на нижнем уровне вторичной базовой станции на основе ведущей функции отбрасывания на верхнем уровне ведущей базовой станции. Ведущая базовая станция перенаправляет пакет данных из верхнего уровня на нижний вторичной базовой станции. Вторичная функция отбрасывания нижнего уровня во вторичной базовой станции отбрасывает принимаемый пакет данных после истечения вторичного таймера, запускаемого посредством нижнего уровня при приеме пакета данных из верхнего уровня в ведущей базовой станции. 4 н. и 6 з.п. ф-лы, 39 ил., 1 табл.
Patent RU-2742372-C2 (RU)
Title: Acrylanilide derivative, a method for production thereof and use thereof in pharmacology
Inventor: SY Tszyujtun
IPC: A61K31/551
Filed: 2016-12-30
Granted: 2021-02-05
Abstract: FIELD: pharmaceuticals.SUBSTANCE: invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof, wherein in formula (I) R1denotes -NR5R6, -OR5or -SR5; X is CR4, Y is N; R2is selected from a group consisting of C1-C6alkoxy or C1-C6alkyl sulfanyl; R3is selected from -N(Rv)RuN(Ry)(Rz), -ORuOR6, -ORuN(Ry)(Rz) and -SRuN(Ry)(Rz); R4and R'4are each selected from the group consisting of hydrogen, halogen, C1-C6alkyl and C1-C6haloalkyl; R5, R6, Ry, Rzare as specified in claim 1; Ruis C1-C6alkylene; Rvis selected from hydrogen and C1-C6alkyl. Invention also relates to specific compounds specified in cl. 7 of the formula, to a pharmaceutical composition and to use for preparing a medicinal agent.EFFECT: technical result is compounds of formula (I) and specific compounds of claim 7 as EGFR and/or HER2/ErbB2 PTK inhibitors.11 cl, 19 tbl, 26 ex
Patent RU-2758962-C2 (RU)
Inventor: KUROCHKIN ANDREJ VLADISLAVOVICH
IPC: F25J1/00
Filed: 2018-06-27
Granted: 2021-11-03
Abstract: FIELD: gas industry. 
     SUBSTANCE: invention relates to devices for producing gas-engine fuels by using the pressure difference between the main and distribution pipelines during the reduction of natural gas, it can be used in the gas industry. An installation is proposed that includes a drying unit, a refrigerator, a refrigerating machine, two expanders, a recuperative heat exchanger, a dephlegmator, a separator and a fractionation unit. During the operation of the installation, high-pressure natural gas is dried and divided into two streams, the first stream is fed for cooling in the recuperative heat exchanger, the second one is cooled in the heat exchanger connected to a refrigerating machine. The streams are combined, reduced using the first expander and sent to the lower part of the dephlegmator, where they are subjected to dephlegmation due to countercurrent cooling with low-pressure gas supplied from the separator, which is then heated in the recuperative heat exchanger, mixed with adsorbent regeneration gas supplied from the drying unit, and removed from the installation. The resulting dephlegmation gas is fed to the second expander, where it is reduced and, together with the gases sent from the fractionation unit, is fed to the separator. A wide fraction of light hydrocarbons is removed from the bottom of the separator, which is mixed with phlegm supplied from the bottom of the dephlegmator, and subjected to fractionation to obtain liquefied natural gas and propane-butane fraction.  
     EFFECT: increased output of gas-engine fuels and an expansion of their range. 
     1 cl, 1 dwg
Patent RU-2728964-C2 (RU)
Inventor: GRUBER LEWIS S
IPC: A61K39/395
Filed: 2017-02-16
Granted: 2020-08-03
Abstract: FIELD: biotechnology.SUBSTANCE: what is presented is using a composition containing an anti-AGE antibody for treating metastatic cancer and/or preventing cancer metastases in an individual. Anti-AGE antibody binds with carboxymethyllysine modified protein.EFFECT: invention provides effective destruction of metastatic cancer cells or potentially malignant neoplastic cells.17 cl, 4 dwg, 11 tbl, 7 ex
Patent RU-2731072-C2 (RU)
Title: Cooling device for installation under ceiling of room
Inventor: FRAJGERR Mikhel
IPC: F24F1/0063
Filed: 2017-05-09
Granted: 2020-08-28
Abstract: FIELD: cooling. 
     SUBSTANCE: invention relates to an air cooling device and to a method for cooling air in rooms, in particular in storage rooms accessible to passage or refrigerating chambers. Device for cooling indoor air comprises housing with bottom, cover, made with possibility of direct attachment without clearance to ceiling of room to be cooled, and side wall, in which air outlet installed in housing is located, made a flat and substantially horizontally located heat transfer device, and installed in the housing a fan for suction of ambient air from the room to be cooled, wherein there is possibility of flow of air sucked by fan in fact in vertical direction through flat heat-transfer device and its deviation by fan in horizontal direction to air outlet, wherein fan and air outlet are located above heat transfer device. 
     EFFECT: this eliminates drip-off of condensation water and accumulation of dust and dirt on upper surface of cooling devices, wherein device is made with possibility of compact installation, in particular, has minimum possible height. 
     14 cl, 8 dwg
Patent RU-2756773-C2 (RU)
Inventor: AESCHBACH RODIN
IPC: A61K8/00
Filed: 2017-06-01
Granted: 2021-10-05
Abstract: Предложенная группа изобретений относится к фармацевтической промышленности, а именно к применению композиции для предупреждения и/или лечения заболевания, вызванного бактериями  P. aeruginosa . Применение композиции на основе CBD, содержащей CBD в концентрации от 1,9 мкг/мл до 200 мг/мл, для предупреждения и/или лечения заболевания, вызванного бактериями  P. aeruginosa , где заболевание или нарушение выбрано из группы, состоящей из внутрибольничной инфекции, инфекций дыхательных путей, инфекций кожи и мягких тканей, раневых инфекций, зубных и буккальных инфекций, оториноларингологических инфекций, инфекций мочевыводящих и/или предстательных путей, желудочно-кишечных инфекций, инфекции желчевыводящих путей, глазных инфекций, бактериемии, сепсиса, инфекций центральной нервной системы и эндокардита. Способ предупреждения и/или лечения заболевания, вызванного бактериями  P. aeruginosa , где заболевание или нарушение выбрано из группы, состоящей из внутрибольничной инфекции, инфекций дыхательных путей, инфекций кожи и мягких тканей, раневых инфекций, зубных и буккальных инфекций, оториноларингологических инфекций, инфекций мочевыводящих и/или предстательных путей, желудочно-кишечных инфекций, инфекции желчевыводящих путей, глазных инфекций, бактериемии, сепсиса, инфекций центральной нервной системы и эндокардита, причем указанный способ включает введение терапевтически эффективного количества композиции, содержащей CBD в концентрации от 1,9 мкг/мл до 200 мг/мл, нуждающемуся в этом субъекту. Вышеописанные применение и способ эффективны для ингибирования формирования биопленки и/или вирулентности  P. aeruginosa , для   предупреждения и/или лечения заболевания, вызванного бактериями  P. aeruginosa.  2 н. и 7 з.п. ф-лы, 2 ил., 1 табл., 3 пр.
Patent RU-2766687-C2 (RU)
Title: Device for determining heart rate and related systems and methods
Inventor: PEREZ-CAMARGO GERARDO
IPC: G01D5/241
Filed: 2018-08-27
Granted: 2022-03-15
Abstract: FIELD: medical equipment. 
     SUBSTANCE: group of inventions relates to a device, a system and a method for determining heart rate of an animal. Device comprises a capacitive displacement sensor connected to a strap designed to be worn by an animal over animal skin. Said capacitive displacement sensor comprises two electrodes. Said capacitive displacement sensor is configured to detect a pulse by generating a signal, associated with a change in the distance between the skin of the animal wearing said device and said capacitive displacement sensor. Said two electrodes include an external transmitting electrode configured to transmit signals and an internal receiving electrode, configured to receive signals. System comprises i) a capacitive displacement sensor connected to a pad to be worn by an animal over the skin of the animal. Said capacitive displacement sensor comprises two electrodes. Said capacitive displacement sensor is configured to detect pulses by generating a signal, associated with a change in the distance between the skin of the animal carrying said system and said capacitive displacement sensor. Said two electrodes include an external transmitting electrode configured to transmit signals, and an internal receiving electrode configured to receive signals. System includes (ii) a signal processor configured to receive signals from said capacitive displacement sensor. Signals contain information on said pulses. Signal processor is configured to detect peaks of said pulses based on the obtained information and determine the shape of the heart rate signal. Method is characterized by that pulses are detected using a capacitive displacement sensor, which generates a signal, which relates to change in distance between said capacitive displacement sensor and skin of an animal carrying said capacitive displacement sensor. Method involves converting signals from said capacitive displacement sensor into a heart rate signal. Said signals contain information on said pulses. 
     EFFECT: creation of an approach to obtaining a heart rate and a heart rate signal, which can significantly improve reliability and accuracy of data and surpass the capabilities of other existing technologies. 
     22 cl, 10 dwg
Patent RU-2770020-C2 (RU)
Title: Method for injection of filler-containing suspension into fibrous structure and method for manufacture of part of composite material
Inventor: DISS PASCAL
IPC: B29C70/24
Filed: 2018-09-18
Granted: 2022-04-14
Abstract: FIELD: molding.SUBSTANCE: invention relates to a method for manufacturing parts of composite material by a liquid-phase method. According to the invention, injection of a filler-containing suspension into a fibrous structure having three-dimensional or multilayered weaving is carried out using at least one hollow needle communicating with a device supplying the filler-containing suspension, while each needle pierces the thickness of the fibrous structure, and it is moved between the first side and the second opposite side of the fibrous structure in such a way that to inject the filler-containing suspension into the fibrous structure to one or several certain depths. Each needle is movable in at least one direction. The needle or needles is stopped in intermediate positions between two sides of the fibrous structure, and a certain dose of the filler-containing suspension is injected. Threads of the fibrous structure and suspension filler are made of heat-resistant ceramic materials.EFFECT: obtaining material or part with low content of macropores and the possibility of adaptation of the method to different geometrical shapes of performed parts.10 cl, 6 dwg
Patent UA-38880-C2 (UA)
Title: Method for determining deflection of a gun tube
Inventor: BRUKH HEORHII ANDRIIOVYCH
IPC: G01B11/00
Filed: 2000-11-10
Abstract: The proposed method for determining deflection of a gun tube consists in generating a modulated optica radiationl beam, directing the beam along the longitudinal axis of the gun tube, providing the reflection of the beam from a reflector installed at the end part of the gun tube, focusing the reflected optical radiation by a lens, and receiving the focused optical radiation by a photodetector.
Patent UA-45181-C2 (UA)
Title: Method for fullerenes obtaining
Inventor: BOHUSLAVSKYI LEONID ZYNOVIIOVY
IPC: C01B31/02
Filed: 2001-06-12
Abstract: Method for fullerenes obtaining comprises evaporating graphite and forming a high-temperature carbon plasma, at supplying voltage to the electrodes, fullerenes cooling, obtaining solution with fullerenes in non-polar solvent, separating fullerenes into clusters of one type by the methods of liquid chromatography. Electrodes are placed to non-polar solvent, at a distance between those, to the inter-electrode space carbon robs are placed, thus linking the electrodes. Evaporation of graphite, formation of high-temperature plasma and obtaining the solution with fullerenes are carried out via applying to the electrodes pulses of high voltage, kV in value, with energy stored in one pulse J.
Patent UA-74547-C2 (UA)
Title: Pharmaceutical composition based on anticholinergic compounds and beta-mimetics and method for its production
IPC: A61P11/08
Filed: 2000-05-03
Abstract: The invention relates to novel medicament compositions, based on anticholinergic compounds and beta-mimetics which are effective on a long-term basis. The invention also relates to a method for producing the same and to their use in the treatment of diseases of the respiratory tract.
Patent UA-72006-C2 (UA)
Title: Fixation for connecting two structural elements
IPC: F16B21/02
Filed: 2002-04-30
Abstract: In a fixation for connecting two structural elements , in particular, plates, with application of a clip unit placed in the first structural element, and a releasing bushing installed in the second structural element by means of an insertion pin 1 moving with respect to the releasing bushing in the long direction by means of pressing unit and releasing it by means of the cone, to provide the largest possible separation of the releasing bushing at the larger segment of the pin 1, there is provided on the last one a cone-like boss 7 acting as a cone, its long axis 8 is arranged with side displacement with respect to the long axis 9 of the pin.
Patent UA-73793-C2 (UA)
Title: Follower electric steering gear
Inventor: YAKOVENKO PETRO OLEKSIIOVYCH
IPC: F42B15/01
Filed: 2003-03-06
Abstract: This invention relates to rocket engineering, in particular to electric steering gears, for instance, in the systems of control of pilotless aircrafts. For stabilization of dynamical characteristics of electric steering gear and to increase accuracy of processing of control signals under conditions of external and destabilization factors, to electric drive there are included a modeling unit, this reflects the desirable transfer function in the band of transmission of the drive, comparison unit and correction channel, this is a proportional-integro-differential controller.
Patent UA-72826-C2 (UA)
Title: Magnetic field strength transducer
Inventor: BOLSHAKOVA INESA ANTONIVNA
IPC: H01L43/10
Filed: 2003-03-31
Abstract: The present invention relates to semiconductor magnetic field strength transducers using the Hall effect. The proposed transducer contains a substrate with a semiconductor layer, two current contacts, and a number of voltage contacts, which are connected to the semiconductor layer. Each currant contact is connected to one voltage contact. All the contacts of the transducer are arranged on one side of the semiconductor layer. The present invention allows the measurement accuracy of the transducer to be increased.
Patent UA-83372-C2 (UA)
Title: Stove with top disposition of combustion chamber, having heat insulation layers in preliminary chamber
Inventor: YAO CHAOSHENG
IPC: C21B9/06
Filed: 2004-12-30
Abstract: A top-combustion type hot-mast stove with a heat insulation layer in the pre-combust chamber longer service life of the top-combustion type hot-blast stove is achieved with the a heat insulation layer in the pre-combust chamber. Through setting heat insulation layers in pre-combust chamber, the hot-blast stove blocks the path between the inner wall of pre-combust chamber and the inner wall of coal gas annular cavity and air annular cavity, reduces the temperature of the inner wall of coal gas annular cavity and air annular cavity, temperature stress and heat expansion of the inner wall of pre-combust chamber, furthermore it makes the slide freely between the inner wall of pre-combust chamber and the inner walls of coal gas annular cavity and air annular cavity and doesn't generate force to inner wall of coal gas annular cavity and air annular cavity, accordingly increasing the service life of the hot-blast stove. At the same time, it sets an annular insulation layer in the second lining between the coal gas annular cavity and the air annular cavity. The inner wall of pre-combust chamber is a conical structure. A removable temperature isolation cover is set between the pre-combust chamber and the arch crown. According to the demand, it can increase the mixture effect of the coal. Gas and air and reduce radiant heat of the hot blast to the pre-combust chamber in case of blowing.
Patent UA-83527-C2 (UA)
Title: Method for production of polyphenol complex possessing predominantly hemostatic and diuretic activities
Inventor: VOLKOVOI VALERII ARKADIIOVYCH
IPC: A61P13/00
Filed: 2006-07-13
Abstract: The invention relates to a method for production of a polyphenol complex possessing predominantly hemostatic and diuretic activities by extraction of the shoots of the European dewberry with 50% ethanol at the 1:8-9 ratio raw material : extractant. The extract is stripped until the removal of ethanol. The precipitate is washed three times with hot water. The aqueous fraction is combined with the supernatant prior to the stage of the stripping before the treatment with the equal volume of 95% ethanol for separating proteins and polysaccharides. The method allows for production of the dry extract possessing marked pharmacological activities useful for various pharmaceutical compositions.
Patent UA-88051-C2 (UA)
Title: Aliiev's connection lock for water lift installation string pipes
Inventor: ALIIEV NATIKBEK ALIIEVYCH
IPC: E21B17/02
Filed: 2007-08-27
Abstract: Box and pin of lift pipes column comprises a stand, connector and junction box, those are connected between them by tool-joint thread. The ends of stands are correspondingly connected to outer ends of the connector and junction box by means of interference fit. In mounting surface area circle-wise with uniform spacing cylinder fit openings are formed, to which conical bolts tightened with nuts are set on from the inner pipe space, ends of the stand are expanded to annular grooves formed in each element of the joint, and the ends of those are welded to the pipe body.
Patent UA-88723-C2 (UA)
Title: Multipurpose heat pump and method of its operation
Inventor: PASTUSHENKO EDUARD PETROVYCH
IPC: F25B29/00
Filed: 2008-03-17
Abstract: The invention relates to heating and cooling systems, in particular for heating and hot water supply of dwelling and industrial objects and in systems for air conditioning. A heat pump has heat exchanger – evaporator (3), compressor (2), heat exchanger – condenser (4), heat exchanger – heater (5), throttle (6), circulation pump (8) that pumps heat carrier from source (7) of low-potential heat, and control device. Circuit of heat pump is connected to outer circuit, heating circuit and cooling circuit. Heat-exchanger-heater (5) placed upstream of throttle (6) heats with residual heart a heat carrier that circulates in external circuit. Cooling circuit includes circulation pump (11) and heat exchanger – cooler (12). The heat carrier of the outer circuit is passed through the source (7) and the heater (5). Heat obtained is transferred through the evaporator (3) to circuit of heat pump. Heat obtained is transferred through condenser (4) to heating system (10). For cooling air, heat carrier of outer circuit downstream of the source (7) is directed to cooler (12). At that heat balance of the source (7) is maintained. The invention promotes effective operation and simplification of construction of the heat pump with use of geo-thermal energy.