Patent SG-11201906498W-A (SG)
Title: System and method with fiducials in non-rectilinear layouts
Inventor: VIECELI JOHN S
IPC: G01N21/64
Filed: 2018-01-31
Abstract: DEBLOCKSTATION ,12 / 16 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT mu °million °nolo olomommiloommovoimIE (10) International Publication Number WO 2018/144567 Al (51) International Patent Classification: GO1N 21/64 (2006.01) (21) International Application Number: PCT/US2018/016180 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701688.2 01 February 2017 (01.02.2017) GB (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, California 92122 (US). (72) Inventors: VIECELI, John S.; 1498 Flair Encinitas Dri- ve, Encinitas, California 92024 (US). NEMIROSKI, Alex; 5205 Fiore Ten, Apt. B410, San Diego, California 92122 (US). BELITZ, Paul; 5200 Illumina Way, San Diego, Cal- ifornia 92122 (US). LANGLOIS, Robert; 5200 Illumi- na Way, San Diego, California 92122 (US). BOWEN, M. Shane; 5200 Illumina Way, San Diego, California 92122 (US). CHAN, Danny Yuan; 5200 Illumina Way, San Diego, California 92122 (US). VENKATESAN, Bala Mu- rali K.; 499 Illinois Street, Suite 210, San Francisco, Cal- ifornia 94158 (US). HAN, Hui; 5200 Illumina Way, San Diego, California 92122 (US). SAMIEE, Kevan; 5200 Il- lumina Way, San Diego, California 92122 (US). TANNER, Stephen; 5200 Illumina Way, San Diego, California 92122 (US). (74) Agent: DIERKER, Julia Church et al.; Dierker & Ka- vanaugh, P.C., 3331 W. Big Beaver Road, Suite 109, Troy, Michigan 48084 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: SYSTEM AND METHOD WITH FIDUCIALS IN NON-RECTILINEAR LAYOUTS (57) : Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that that enhance their detection in image or detection O data, that facilitate or improve processing, that provide encoding of useful informa- tion, and so forth. Examples of the fiducials may include non-rectilinear layouts that may provide for more robust location of both the fiducials and sites of the array. NUCLEOTIDE DELIVERY SYSTEM 12 1 X14 W O 20 18/ 1445 67 Al 24-i H FLUSH STATION 28 12 IMAGING SYSTEM DATA ANALYSIS SYSTEM r 18 PROW C N E T S R SS ING EA M W STORAGE SYSTEM FIG. 1 [Continued on next page] WO 2018/144567 Al MIDEDIMOMMIDIREEMOMOEMOHERIEHMEMOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))