Patent SG-11201901307V-A (SG)
Title: Heterodimeric immunoglobulin constructs and preparation methods thereof
Inventor: LIU JIAWANG
IPC: C12N15/13
Filed: 2017-09-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 1110101011111 011101 0 0111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/059502 Al 05 April 2018 (05.04.2018) WIP0 I PCT (51) International Patent Classification: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, C07K 16/00 (2006.01) A61P 37/02 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/CN2017/104044 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (22) International Filing Date: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 28 September 2017 (28.09.2017) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (25) Filing Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English (30) Priority Data: Published: 201610863814.7 29 September 2016 (29.09.2016) CN — with international search report (Art. 21(3)) — (71) Applicant: BEIJING HANMI PHARMACEUTICAL with sequence listing part of description (Rule 5.2(a)) CO., LTD. [CN/CN]; No.10 Tianzhu West Road, Tianzhu Airport Industrial Zone A, Shunyi District, Beijing 101312 (CN). (72) Inventors: LIU, Jiawang; c/o Beijing Hanmi Pharmaceu- _ tical Co., Ltd., No. 10 Tianzhu West Road, Tianzhu Air- port, Industrial Zone A, Shunyi District, Beijing 101312 = (CN). SONG, Nanmeng; c/o Beijing Hanmi Pharmaceuti- _ cal Co., Ltd., No. 10 Tianzhu West Road, Tianzhu Airport, = _ Industrial Zone A, Shunyi District, Beijing 101312 (CN). = YANG, Dongge; c/o Beijing Hanmi Pharmaceutical Co., = Ltd., No. 10 Tianzhu West Road, Tianzhu Airport, Industri- = al Zone A, Shunyi District, Beijing 101312 (CN). YANG, = _ Yaping; c/o Beijing Hanmi Pharmaceutical Co., Ltd., No. _ 10 Tianzhu West Road, Tianzhu Airport, Industrial Zone A, Shunyi District, Beijing 101312 (CN). KIM, Maengsup; c/ o Beijing Hanmi Pharmaceutical Co., Ltd., No. 10 Tianzhu — West Road, Tianzhu Airport, Industrial Zone A, Shunyi Dis- trict, Beijing 101312 (CN). = Agent: BEIJING INTELLEGAL INTELLECTUAL (74) PROPERTY AGENT LTD.; 1802, 1803, 1805 Tower B, = _ _ Grand Place, No 5 Huizhong Road, Chaoyang District, Bei- jing 100101 (CN). = (81) Designated States (unless otherwise indicated, for every — kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = _ 1-1 ei © kr) 0\ kr) C:::: ) (54) Title: HETERODIMERIC IMMUNOGLOBULIN CONSTRUCTS AND PREPARATION METHODS THEREOF --.... 00 ,1 (57) : Provided is a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., Ws- = pecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can \" simultaneously bind two target molecules and are more potent in the treatment of complex diseases.