baber/WOPTO huggingface dataset:
Patent EP-3775908-A1 (EP)
Inventor: MAGNON CLAIRE
IPC: A61K45/06
Filed: 2019-04-15
Abstract: The invention relates to methods for predicting the outcome of a patient suffering from prostate cancer or breast cancer and methods for the treatment of prostate cancer or breast cancer. The inventors show that Doublecortin-expressing (DCX + ) neural precursors from the central nervous system (CNS) enter the bloodstream, infiltrate prostate tumours and metastasis and differentiate into neo-neurons that contribute to tumour development. In human primary prostate tumours and transgenic mouse cancer tissues, the density of DCX +  neural progenitors is strongly associated with tumour aggressiveness, invasion and recurrence. In transgenic cancer mice, oscillations of DCX +  neural stem cells in the subventricular zone (SVZ), a neurogenic area of the CNS, were associated with egress of DCX +  cells from the SVZ to the bloodstream. These cells then reach the tumour where they initiate neurogenesis. Selective genetic depletion of DCX +  cells in mice inhibits the early phases of prostate cancer development, whereas ortho topic transplantation of DCX +  cells purified from prostate tumour or brain tissues promotes tumour growth and cancer cell dissemination. These results unveil a unique crosstalk between the CNS and the tumour that drives a process of neurogenesis necessary for prostate cancer development, and indicate a novel neural element of the tumour microenvironment as a potential target for cancer treatment. Thus, the invention relates to a method for predicting the outcome of a patient suffering from prostate cancer and compound targeting DCX +  neural progenitor cells for use in the treatment of prostate cancer.
Patent EP-3774569-A1 (EP)
Inventor: CEPA PAWEL
IPC: B65D41/42
Filed: 2019-03-25
Abstract: An easily openable pull-off beverage bottle closure consisting of a shell, a pull tab (5) and a liner (3) covering the inner section of the shell providing circumferential sealing, where the shell has upper closing plane (1) and a skirt wall (2) shaped from the outer part of the upper part of the closing plane, and the pull tab is connected with the skirt wall, where the shell has score lines (4) running on the both sides of the pull tab from the skirt wall through the upper plane enabling to tear off the closure is characterized in that, the liner (3) is affixed to the inner upper section of the closing plane (1) and it covers the surface bigger than the surface limited by the score lines (4) running through the upper plane of the shell.
Patent EP-3774760-A1 (EP)
Title: Pladienolide derivatives as spliceosome targeting agents for treating cancer
Inventor: COOK ANDREW
IPC: C07D405/06
Filed: 2019-04-11
Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.
Patent EP-3781475-A1 (EP)
Inventor: NOPPEL FRANK GUNTER
IPC: B64D27/02
Filed: 2019-04-17
Abstract: Methods, apparatus, systems and a vertical take-off and landing (VTOL) vehicle are provided. The VTOL vehicle includes: a fuselage having longitudinally a front section, a central section and a rear section; a first lifting surface comprising two wings respectively secured to opposite sides of the rear section of the fuselage; a second lifting surface comprising two wings respectively secured to opposite sides of the front section of the fuselage; where each wing and/or fuselage section comprises at least one engine module, each of the engine modules being pivotally coupled to the wing and/or fuselage and each engine module being independently controlled for transitioning between a vertical mode of flight and a horizontal mode of flight.
Patent EP-3791505-A1 (EP)
Title: Arq/harq-related procedure for grant-free random access
Inventor: UTKOVSKI ZORAN
IPC: H04L1/18
Filed: 2019-05-10
Abstract: A user equipment, UE, for a wireless communication network including one or more base stations, performs a transmission to a base station using a grant-free, GF, transmission scheme. The transmission being performed in accordance with a GF transmission configuration. The UE receives from the base station a certain signaling. The certain signaling indicates that the base station failed to identify the UE from the transmission. Responsive to the certain signaling from the base station, the UE retransmits the transmission in accordance with a GF retransmission configuration. The GF retransmission configuration is different from the GF transmission configuration.
Patent EP-3949094-A1 (EP)
Inventor: TIRELLA VINCENZO
IPC: H02K33/16
Filed: 2019-04-05
Abstract: The present invention generally relates to a system for generating a linear movement, comprising an electromagnetically charged body (30, MM) which is free to move along a main direction, a static field generator (50, Bob), and two buffer elements (20,40; RM,RM; ML, ML; ΜΑ,ΜΑ; MF,MF). The movement of the electromagnetically charged body (30, MM) along the main direction is controlled by the static field generator (50, Bob) and by the buffer elements (20,40; RM,RM; ML, ML; ΜΑ,ΜΑ; MF,MF). The static field generator (50, Bob) is alternately powered with a power profile such as to generate the displacement of the system in one of the two ways along said main direction.
Patent EP-3802835-A1 (EP)
Inventor: KAULICH MANUEL
IPC: C12N15/63
Filed: 2019-06-11
Abstract: La présente invention concerne un nouveau procédé de génération d'une construction de vecteur convenant à des applications d'édition génique, qui comprend une paire fixe de séquences d'ARN guide (ARNg) exprimables prédéterminées. Le procédé de l'invention permet une construction aisée de ces vecteurs et fournit en plus des banques de vecteurs pour l'expression de paires fixes d'ARNg. Les vecteurs de l'invention peuvent être avantageusement utilisés pour découper de plus grandes séquences d'ADN génomique, ou encore pour introduire simultanément des mutations dans le génome sans perte ou séquences génomiques plus grosses. Le système de l'invention fournit donc de nombreuses approches de génétique moléculaire pour l'altération du génome.
Patent EP-3810097-A1 (EP)
Inventor: CARITE CHRISTOPHE
IPC: A61K35/38
Filed: 2019-06-19
Abstract: L'invention concerne une forme posologique entérique comprenant un produit biothérapeutique vivant.
Patent EP-3806655-A1 (EP)
Inventor: BAYLE JULIE
IPC: A23K50/40
Filed: 2019-06-13
Abstract: La présente invention concerne une composition d'aliment pour chien comprenant entre environ 10% en poids et environ 20% en poids de graisse, entre environ 5% en poids et environ 15% en poids de fibres et entre environ 30 % en poids et environ 60% en poids de protéines, les pourcentages pondéraux étant basés sur le poids total de matière sèche de la composition.
Patent EP-3741388-A1 (EP)
Title: Immunogenic composition
Inventor: FUJIMOTO Miya
IPC: C07K7/08
Filed: 2019-01-18
Abstract: Provided is an immunogenic composition which comprises a self-assembled peptide as an adjuvant and can increase the immunogenicity of various antigens. The present invention provides an immunogenic composition comprising: a peptide hydrogel containing a positively or negatively charged self-assembled peptide and an aqueous medium, and an antigen, in which the self-assembled peptide is not covalently bonded to the antigen.
Patent EP-3830163-A1 (EP)
Inventor: ZHANG JINTAO
IPC: C08G18/10
Filed: 2019-07-26
Abstract: The invention relates to a 2K coating composition comprising a polysiloxane-modified polyurethane and a hardener, wherein the polysiloxane-modified polyurethane obtainable by a method comprising the following steps: a) subjecting a polyol to a reaction with an isocyanate-functional silane coupling agent to obtain a silane-grafted polyol,and b) subjecting the silane-grafted polyol to a condensation reaction with a hydroxyl-functional polysiloxane, to obtain the polysiloxane-modified polyurethane.The polysiloxane-modified polyurethane can be used in a coating composition to form a coating which has smooth feel, stain resistance and easy clean properties, particularly desired in the field of e.g. consumer electronics and automotive industry.
Patent EP-3739194-A1 (EP)
Inventor: HITOMI MITSUO
IPC: F02D41/32
Filed: 2019-01-23
Abstract: An engine control method includes: a first fuel supply step (6041) of supplying fuel into the combustion chamber using a fuel supply unit (i.e., an injector 6) when an ignition unit (i.e., a spark plug 25) makes flame in the combustion chamber so that air-fuel mixture is generated at least around the ignition unit, the air-fuel mixture having an air-fuel mass ratio A/F or a gas-fuel mass ratio G/F, in which gas includes air, higher than a stoichiometric air-fuel ratio; after the first fuel supply step, an ignition step (6042) of making the flame in the combustion chamber in the compression stroke using the ignition unit; and after the ignition step, a second fuel supply step (6043) of supplying the fuel into the combustion chamber in the compression stroke using the fuel supply unit to increase a fuel concentration of the air-fuel mixture in the combustion chamber.
Patent EP-3821216-A1 (EP)
Inventor: FRIDMAN ANDREI L
IPC: G01J3/28
Filed: 2019-07-09
Abstract: L'invention concerne un système optique pour une caméra hyperspectrale ainsi qu'une caméra hyperspectrale comprenant un tel système optique. Le système optique comprend un dispositif optique avant (1000), un capteur d'image (1800), une fente (1500), un dispositif optique de relais (1200), un premier élément optique (2000) positionné avant la fente (1500), le premier élément optique (2000) défocalisant la lumière dans une direction parallèle à la fente (1500) tout en maintenant la focalisation dans une direction perpendiculaire à la fente (1500) ; et un second élément optique (2100) positionné après la fente (1500), le second élément optique (2100) compensant la défocalisation de la scène représentée introduite par le premier élément (2000).
Patent EP-3806777-A1 (EP)
Inventor: ZALDIVAR ROGER
IPC: A61F2/16
Filed: 2019-08-14
Abstract: The invention relates to a posterior chamber phakic intraocular lens (1) comprising a central optical part (2), a peripheral haptic part (3) comprising a plurality of support elements (4A-D) arranged to lie on a ciliary zonule of an eye, and a plurality of flexible elongated haptics (5A-D) arranged to hook into a ciliary sulcus of the eye.
Patent EP-3713649-A1 (EP)
Inventor: BÖKE JOACHIM
IPC: A62C35/68
Filed: 2019-08-08
Abstract: The invention relates to a water extinguishing system (1), comprising: a fluid supply (20); a pump (30); and a testing line (40) having an opening element (2), which opening element is designed to open the testing line (40) in a test run of the pump (30). According to the invention, the testing line (40) also comprises a shut-off element (4), which is designed to close the testing line (40) when the water extinguishing system (1) is activated.
Patent EP-3981190-A1 (EP)
Title: Method and apparatus for enforcement of maximum number of protocol data unit sessions per network slice in a communication system
Inventor: WON SUNG HWAN
IPC: H04W28/16
Filed: 2019-06-10
Abstract: Methods, systems, apparatuses, and computer program products for providing an enforcement mechanism for the maximum number of PDU sessions per network slice in a communication system are provided. A method, system, and apparatus may receive, from a user equipment (UE), a protocol data unit (PDU) session establishment request message and Single Network Slice Selection Assistance Information (S-NSSAI) through an access network (AN). The method, system, and apparatus may cause, upon detecting that the S- NSSAI is subject to the capping number of PDU sessions per network slice, transmission of a service request message to a network slice selection function (NSSF). The service request message includes an indication indicating that the S-NSSAI is subject to a capping number of PDU sessions per network slice. The indication may cause the NSSF to increment a counter associated with PDU sessions for a network slice associated with the S-NSSAI.
Patent EP-3844676-A1 (EP)
Inventor: KOLLIG PETER
IPC: G06K19/07
Filed: 2019-08-27
Abstract: A device for communication with a terminal. The device comprises: a communication unit for communicating with the terminal; a biometric unit comprising a biometric sensor for sensing biometric data; contacts for connecting the device to the terminal; a first physical interface between the biometric unit and the contacts configured to enable contact communication between the biometric unit and the terminal; and a second physical interface between the communication unit and the biometric unit configured to enable contact communication between the communication unit and the biometric unit. The device is configured such that all contact communications between the terminal and the communication unit are routed through the biometric unit via the first and second physical interfaces.
Patent EP-3764988-A1 (EP)
Inventor: HSU SHEAU YU TEDDY
IPC: C07K14/00
Filed: 2019-03-14
Abstract: Stable aqueous gel or semisolid gel pharmaceutical composition comprising a gel-forming and water-soluble peptide are optionally combined with an appropriate excipient and a therapeutic agent. The pharmaceutical composition forms a gel depot following administration to an individual, where the gel nanostructure releases the peptide or the encapsulated therapeutic agent(s) over a extended period of time. The gel-forming compounds can be formulated in aqueous, suspension, or solid formulations, comprising 0.01 % to 99% of a gel-forming polypeptide by weight with relation to the total weight of the formulation. These formulations are useful in drug delivery and as implantable drug depot for long term delivery of therapeutic agents, antigens, or cells. Also provided are methods of producing a gel-forming compound, through the modification of a chemical compound with a gel-forming enhancing motif.
Patent EP-3860934-A1 (EP)
Inventor: MILHEM FRANCK
IPC: B65F1/06
Filed: 2019-10-01
Abstract: A flexible container (1) for packaging waste, comprising: • an outer casing (2) forming the outer surface (5) of the container and having, in a top part, an opening (13) that can be opened or closed, • an inner casing (3) delimiting an inner space (V) of the container for receiving and accommodating the waste, arranged inside the outer casing (2), the inner casing (3) comprising, in a top part, an opening (51) that can be opened or closed by means of a closure system (510) attached to the inner casing, and • at least one reinforcing strip (40) superimposed at least partially on and attached to the closure system (510) and to the inner casing.
Patent EP-3779388-A1 (EP)
Inventor: ENDO TAKAYUKI
IPC: G01L3/10
Filed: 2019-02-08
Abstract: A torque sensor which can detect a torque with high accuracy without depending on the accuracy of machining the structure and the displacement accuracy of the strain gauge with respect to the structure is provided. First structure 11 and second structure 12 are connected by a plurality of third structures 13. First and second strain sensors 19, 20 are connected between the first structure and the second structure. Each of the first and second strain sensors includes a strain body 41 connected between the first structure and the second structure and a plurality of sensor elements 51, 52, 53, 54 provided on the strain body. The sensor elements are disposed in a region of one side of each of the first structure and the second structure with respect to a longitudinal central portion of the strain body, and the region on the one side is a region where there is only a little difference in strain between along a torque direction of the strain body and a torque-excepted direction.
Patent EP-3948505-A1 (EP)
Inventor: ISAAC SHANE
IPC: H04W4/14
Filed: 2019-03-29
Abstract: A system for allowing messaging between a first computing device and a second computing device includes a first messaging module which provides a first message field. In response to the entry of the text elements, a processor compiles timing data associated with the text elements and generates a message that is indicative of the text elements and the timing data. The system includes a communication module allowing communication of the message. The system includes a second messaging module which is responsive to the message for extracting the text elements and the timing data and for providing a second message field on interface to playback the text elements to user in accordance with the timing data.
Patent EP-3773880-A1 (EP)
Inventor: BALDONI DANIEL
IPC: A61N1/36
Filed: 2019-03-29
Abstract: Systems and methods for treating a patient having a blood glucose abnormality, such as type 2 diabetes (T2D), using an electrical signal are disclosed. A representative method for treating a patient includes, based at least in part on a patient indication of a blood glucose abnormality, positioning at least one implantable signal delivery device proximate to a target location at the patient's spinal cord within a vertebral range of from about C8 to about T12. The method further includes directing an electrical signal to the target location via the implantable signal delivery device, wherein the electrical signal has a frequency in a frequency range of from 1.2 kHz to 100 kHz.
Patent EP-3846899-A1 (EP)
Inventor: MELLEM KRZYSZTOF
IPC: A61N2/02
Filed: 2019-09-01
Abstract: The subject of the invention is a system for inducing an electric field in a conducting medium, especially for medical applications. The system according to the invention induces a flow of electric current through objects located in the conducting medium (7), which may have shapes that are complex or change with time, and has a medical application consisting in a complete or partial nerve impulse block. The system for inducing an electric field in the conducting medium (7) comprises at least two component cores (2), whose magnetization is configured to be changed independently by a change of electric currents flowing through windings (5) that are wound around them, and a torus-shaped encasement (3) whose outer surface is electrically non-conductive, wherein the component cores (2) are situated inside the encasement (3) and encircle its opening, and the encasement (3) is situated inside the conducting medium (7).
Patent EP-3861663-A1 (EP)
Inventor: ANDERSSON MATTIAS
IPC: H04L5/00
Filed: 2019-10-04
Abstract: Systems and methods for adapting a timer(s) for a satellite-based radio access network are disclosed. Embodiments of a method performed by a user equipment or a base station and corresponding embodiments of a user equipment or a base station are disclosed. In some embodiments, a method performed by a user equipment or a bases station comprises obtaining an amount of resources elements available and determining a transport block size based on the amount of resources elements available. In some embodiments, repetitions are used. In some embodiments, obtaining the available resource elements amount is based on at least one of: one or more explicit calculations and/or one or more signaled scaling factor(s). In some embodiments, the method further comprises determining (or selecting) a modulation and code rate (MCS) based on the amount of resources elements available.
Patent EP-3786179-A1 (EP)
Inventor: KITANO SHIRO
IPC: C12N5/071
Filed: 2019-05-07
Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component, wherein at least a part of the fragmented extracellular matrix component is crosslinked.
Patent EP-4004917-A1 (EP)
Title: Multi-channel acoustic event detection and classification method
Inventor: GEVREKCI LÜTFI MURAT
IPC: G10L25/30
Filed: 2019-07-30
Abstract: The present invention relates to a multi-channel acoustic event detection and classification method for weak signals, operates at two stages; first stage detects events power and probability within a single channel, accumulated events in single channel triggers second stage, which is power-probability image generation and classification using the tokens of neighbouring channels.
Patent EP-3863662-A1 (EP)
Inventor: KYOSTIO-MOORE SIRKKA
IPC: A61K38/44
Filed: 2019-10-11
Abstract: Provided herein are variant phenylalanine hydroxylase (PAH) polypeptides which are more stable and have greater activity than wild-type human PAH. Also provided are methods to treat phenylketonuria (PKU) and/or to reduce levels of phenylalanine in an individual in need thereof. Further provided herein are expression cassettes, vectors ( e.g ., rAAV vectors), viral particles, pharmaceutical compositions and kits for expressing the variant PAH polypeptide in an individual in need thereof.
Patent EP-3880793-A1 (EP)
Inventor: CHAKKAR YASSIN
IPC: C12M1/12
Filed: 2019-11-12
Abstract: A tool for fixating and handling membrane-shaped tissue for research or clinical use. The tool comprises a platform comprising a base plate having at least one positioning element for positioning a spanning element on the platform, at least one round shaped spanning element adapted for being positioned on the platform using the positioning element, at least one flexible element for positioning over the round shaped spanning element for spanning the membrane shaped tissue, and at least one handling means for handling the flexible element during positioning of the flexible element over the round shaped spanning element, and for handling the combination of the round shaped spanning element and the flexible element, when the membrane is spanned over the round shaped spanning element.
Patent EP-3880249-A1 (EP)
Inventor: HERGES RAINER
IPC: C07D491/22
Filed: 2019-11-15
Abstract: The compound comprises the general structure of a bacteriochlorin and can be used as a medicament, e.g. in photodynamic therapy, or in a technical process for generating singlet oxygen from gaseous or dissolved oxygen. The compound generates singlet oxygen and is stable against oxidation, e.g. it is not quickly inactivated by the singlet oxygen that it generates under irradiation.
Patent EP-4017701-A1 (EP)
Title: Article en elastomere comportant une surface texturee de type velours et procede de realisation d'un tel article
Inventor: BOURQUARD PASCAL
IPC: B29C37/00
Filed: 2019-11-05
Abstract: L'invention concerne un article manufacturé formé essentiellement d'un matériau élastomère vulcanisé, ledit article présentant au moins une surface visible (10) comportant sur au moins une portion texturée comprenant une pluralité de brins (20) s'étendant depuis une base (21) de ladite surface et répartis sur la totalité de ladite portion, chaque brin (20) ayant une hauteur moyenne A mesurée depuis ladite base jusqu'à une extrémité libre du brin telle que 0,250 mm≤ A≤ 0,600 mm et une largeur moyenne B à la base telle que 0,070 mm ≤ l ≤0,170 mm. L'invention concerne également un procédé de fabrication d'un tel article par moulage d'un matériau élastomère dans un moule dont une surface de moulage comporte sur au moins une portion de surface de moulage une pluralité de cavités (210) ayant une hauteur moyenne h mesurée depuis ladite base jusqu'à une extrémité libre du brin telle que 0,250 mm≤ h≤ 0,600 mm et une largeur moyenne l à la base telle que 0,070 mm ≤ l ≤0,170 mm.