baber/WOPTO huggingface dataset:
Patent EA-011126-B1 (EA)
Title: Novel polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their preparation and pharmaceutical compositions containing them
Inventor: GOLDSTEIN SOLO
IPC: A61P25/28
Filed: 2006-07-27
Abstract: The present invention relates to compounds of formula (I):wherein:n represents an integer 1,Rand R, which may be identical or different, each independently of the other represent a hydrogen atom, a linear or branched (C-C)alkyl group,Rand R, which may be identical or different, each independently of the other represent a hydrogen atom or a linear or branched (C-C)alkyl group, wherein at least one of the two groups Ror Rrepresents a linear or branched (C-C)alkyl group,Rand R, which may be identical or different, each independently of the other represent a hydrogen atom or halogen,its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. The invention also relates to pharmaceutical compositions comprising as an active in ingredient compounds of formula (I) especially useful as a specific nicotinic ligand of [alpha]4[beta]2 receptors.
Patent EA-011494-B1 (EA)
Title: Cholesteric monolayers and monolayer pigments with particular properties, their production and use
Inventor: KASCH MICHAEL
IPC: C09K19/52
Filed: 2005-11-28
Abstract: The invention provides novel cholesteric monolayers and pigments obtained therefrom with high brilliance and viewing angle-dependent colour change (colour-flop/tilt effect) with additional particular properties such as magnetizability, conductivity, fluorescence, phosphorescence and increased hiding power, a process for their production and their use.
Patent EA-012511-B1 (EA)
Title: Collapsible multiway box
Inventor: PANASYUK ANATOLIJ IVANOVICH
IPC: B65D6/16
Filed: 2007-08-17
Abstract: The invention relates to multi-way shipping containers for putting glass bottles therein and other different piece articles. A proposed collapsible multi-way box comprises end walls, a bottom, a box clamps in the working position and horizontal grating made of longitudinal and transverse connecting elements arranged in stages hinged fixed at the end walls and forming cells for putting articles. A novel feature is characterized in that the front and rear end walls are Γ-shaped, left and right end walls are hinged connected to a shortened part of one of Γ-shaped end walls, and from the other side to an elongated part opposite Γ-shaped end wall enabling them to fold in an inoperable position thus reducing to maximum total volume and preserving rectangular configuration convenient for close and compact packing thereof, wherein the left and right side end walls are perpendicular, overhung extending brackets adapted, in a box working position, to arrange them in nests made on said parts of the corresponding Γ-shaped end walls somehow upper and lower relative to the staged horizontal gratings and turn them in a vertical position, when folding a box, with no sagging of horizontally arranged walls and providing sufficient support ability for their multi-way piling and storing; the bottom is also a Γ-shaped structure and in its elongated part is arranged in a labyrinth formed by the end walls enabling to provide rigidity and stability of the box structure in its operation position, and by its shortened part is hinged connected to the rear side of the Γ-shaped end wall able to turn by 270°, in the operation position the box stops adapted to cooperate with the bottom when it is in said labyrinth; each longitudinal and lateral connecting element is a separate member and telescopic thus excluding overloads and breaks in the folded box position; all pivot joints are quick-disconnecting units enabling to replace them and design rearrangement depending on goods to be transported: large and small piece items and bulk materials.
Patent EA-020805-B1 (EA)
Title: Use of combination of cladribine and beta interferon for treating multiple sclerosis
Inventor: BRENTZEL H JAMES JR
IPC: A61P37/06
Filed: 2007-05-23
Abstract: The present invention relates to the use of a combination of cladribine and IFN-beta for the manufacture of a medicament for treating patients suffering from multiple sclerosis and who are refractory to at least one conventional therapy for multiple sclerosis, wherein cladribine is to be orally administered following the sequential steps below: (i) an induction period wherein cladribine is administered and wherein the total dose of cladribine reached at the end of the induction period is from about 1.7 to about 3.5 mg/kg; (ii) a cladribine-free period wherein no cladribine is administered; (iii) a maintenance period wherein cladribine is administered and wherein the total dose of cladribine administered during the maintenance period is lower than or equal to the total dose of cladribine reached at the end of the induction period (i); (iv) a cladribine-free period wherein no cladribine is administered. The present invention also relates to a method of treating a patient suffering from multiple sclerosis a to a kit comprising cladribine and IFN-beta.
Patent EA-013010-B1 (EA)
Title: System and methods for enhancing low-frequency content in vibroseis acquisition
Inventor: BAGAINI CLAUDIO
IPC: G01V1/00
Filed: 2006-12-06
Abstract: This invention relates in general to vibroseis and, more specifically, but not by way of limitation, to the enhancement and/or signal strength optimization of low frequency content of seismic signals for use in surveying boreholes and/or subsurface earth formations. In embodiments of the present invention, physical properties of a seismic vibrator may be analyzed and used to provide for determination of a driving force necessary to drive a reaction mass to produce a sweep signal with enhanced low frequency content for injection into the ground for vibroseis. In certain aspects, the physical properties may be considered independent of any geophysical properties related to operation of the seismic vibrator.
Patent EA-020231-B1 (EA)
Title: Bsas powder
Inventor: MARLIN SAMUEL
IPC: C04B35/195
Filed: 2009-02-13
Abstract: The invention provides a powder comprising at least 95% by number of molten grains having the following chemical composition, in mass percent on the basis of oxides, for a total of 100%: 0≤BaO≤40.8%; 0≤SrO≤31.8%; 27.2%≤AlO≤31.3%; 32%≤SiO≤36.9%; other species ≤1%, wherein the content of at least one of BaO and SrO oxides is higher than 0.3%, the size of said grains ranges from 5 to 150 microns.
Patent EA-018550-B1 (EA)
Title: Absorbent article
Inventor: KUDO JUN
IPC: A61F13/15
Filed: 2009-01-28
Abstract: An absorbent article including an absorbent main body formed at least of a liquid-permeable topsheet configured to come into contact with a skin of a wearer and a liquid-impermeable backsheet configured to come into contact with clothing, the absorbent article comprising a heat-weldable fiber. The cover sheet is in contact with a contact surface of the topsheet bonded to the topsheet at a bonding position by thermo welding at which the topsheet and an excretion portion of the wearer are to be in contact with each other, and both ends of the cover sheet in a longitudinal direction at least partially coincide with or recede from both ends of the absorbent main body in the longitudinal direction, and both ends of the cover sheet in a width direction at least partially coincide with or recede from both ends of the absorbent main body in the width direction. The absorbent main body includes a pair of wings projecting in width directions from the absorbent main body in a state of being unpacked from a packed state, and in the packed state, the pair of wings are folded back on the cover sheet.
Patent EA-018380-B1 (EA)
Title: Pneumatic control valve comprising several pistons
Inventor: CZYPIONKA SIMON
IPC: B60T15/18
Filed: 2010-09-20
Abstract: The invention relates to a pneumatic control valve as an actuator for a regulated application of compressed air to a brake cylinder (8), which can be connected to a valve housing (1) via a C-port (7), in accordance with a pressure difference between a control pressure supplied by an S-port (3) and a reference pressure which is supplied via an A-port (4) and acts in the opposite direction on a control piston (2). According to the invention, said control piston, in cooperation with at least one pressure spring (5), actuates a double-seat valve (6) either for connecting the C-port (7) to an O-port (9) for discharging air or for connecting the C-port (7) to an R-port (10) for ventilation.; Several additional C-pistons (12a, 12b), which cooperate with the control piston (2) and can be alternatively selected, are provided for adjusting several brake pressure levels, wherein a first C-piston (12a) having a smaller diameter and an associated C1-port (13a) is arranged on the piston rod (11), which actuates the double-seat valve (9), at a distance from a second C-port (12b) having a larger diameter and an associated C2-port (13b), wherein a first brake pressure level can be adjusted by subjecting the first C-piston (12a) to a brake cylinder pressure, a second brake pressure level can be adjusted by subjecting the second C-piston (12b) to a brake cylinder pressure and a third brake pressure level can be adjusted by subjecting both C-pistons (12a, 12b) to the brake cylinder pressure.
Patent EA-016786-B1 (EA)
Title: Process for the production of urea from ammonia and carbon dioxide
Inventor: GEVERS LAMBERTUS WILHELMUS
IPC: C07C273/04
Filed: 2009-05-19
Abstract: Process for the production of urea from ammonia and carbon dioxide in a urea plant containing a high-pressure synthesis section comprising two reactor sections, a stripper and a condenser, and a recovery section, wherein in the first reactor section a first synthesis solution is formed that is fed to the second reactor section; fresh carbon dioxide is fed to the second reactor section and in the second reactor section a second synthesis solution is formed that is fed to the stripper, wherein the second synthesis solution is stripped with the use of carbon dioxide as stripping gas and the mixed gas stream obtained in the stripper is sent to the condenser together with fresh ammonia and a carbamate stream, whereafter the condensate that is formed in the condenser is fed to the first reactor section and the urea stream that is obtained in the stripper is further purified in the recovery section, wherein the flow of the first synthesis solution from the first reactor section to the second reactor section, the flow of the second synthesis solution from the second reactor section to the stripper, the flow of the mixed gas stream from the stripper to the condenser and of the condensate from the condenser to the first reactor section is a gravity flow.
Patent EA-018283-B1 (EA)
Title: Agricultural applications of silver dihydrogen citrate
Inventor: KRALL MICHAEL L
IPC: A01N59/16
Filed: 2008-10-15
Abstract: A method for treating a plant, the method comprising contacting a composition comprising silver dihydrogen citrate with at least one of the plant, a portion of soil and/or groundwater proximal to the plant, or a combination thereof.
Patent EA-015957-B1 (EA)
Title: A method and an apparatus for producing liquid flow in a pipeline
Inventor: MELHUS TROND
IPC: F01K1/14
Filed: 2009-04-01
Abstract: There is described a method of producing liquid flow in a pipeline (7, 9) which is provided with at least one turbine device (11, 13) to extract energy from the liquid flow, wherein steam is used to produce liquid flow in the pipeline (7, 9) and through the turbine (11, 13). There is also described an apparatus for practising the method.
Patent EA-025108-B1 (EA)
Title: Improvement of growth of bifidobacteria in fermented milk products
Inventor: FOLKENBERG DITTE MARIE
IPC: A23C9/123
Filed: 2009-08-28
Abstract: The invention relates to a method for the preparation of a fermented milk product comprising Bifidobacteria in combination with lactic acid bacteria of the species Lactococcus lactis, Streptococcus thermophilus, and/or Lactobacillus bulgaricus. The problem to be solved is to provide a method to improve growth of Bifidobacteria population in milk during the fermentation process for making fermented milk products (e.g. a yogurt) in order to obtain a high cell count of Bifidobacteria in the final product.
Patent EA-026341-B1 (EA)
Title: Crystalline form of nucleoside phosphoramidate
Inventor: ROSS BRUCE S
IPC: C07H19/24
Filed: 2011-03-31
Abstract: The present invention relates to a new crystalline form of nucleoside phosphoramidate and the use thereof as an agent for treating viral diseases. This compound is an inhibitor of RNA-dependent RNA viral replication and is useful as an inhibitor of HCV NS5B polymerase, as an inhibitor of HCV replication and for the treatment of hepatitis C infection in mammals.
Patent EA-026904-B1 (EA)
Title: Method for quantitative determination of polyhexamethylene biguanidine (phmb) hydrochloride in compositions for preparing liquid medicinal products for treatment of eye and nose diseases (2 embodiments)
Inventor: YUKHT IGOR MIKHAILOVICH
IPC: G01J3/42
Filed: 2013-01-28
Abstract: The invention is related to the field of pharmacy, in particular, to pharmaceutical chemistry, and to medicinal products preparation technology. The method according to the invention (2 embodiments) makes it possible to determine quantity of polyhexamethylene biguadinine (PHMB) hydrochloride in compositions for preparing liquid medicinal products for treatment of eye and nose diseases, the 1embodiment being intended for compositions without polyvinyl alcohol and the 2one for compositions containing polyvinyl alcohol. The methods for quantitative determination of polyhexamethylene biguadinine (PHMB) hydrochloride are based on measurement of optical density of solutions followed by mathematical calculations. Both methods are highly accurate since they allow determination of PHMB in concentrations of 0.0001-0.02%.
Patent EA-034193-B1 (EA)
Title: Heterocyclic compounds as kinase inhibitors
Inventor: ALMSTETTER MICHAEL
IPC: A61P11/00
Filed: 2012-04-23
Abstract: The present invention relates to novel compounds of formula (I)that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
Patent EA-031128-B1 (EA)
Title: Glyphosate tolerant corn event vco-∅1981-5, kit and method for detecting the same
Inventor: ARTIM MANN LORI
IPC: C12N15/82
Filed: 2012-07-26
Abstract: The present invention relates to the field of plant transformation with genes conferring tolerance to glyphosate. The invention particularly relates to a maize (corn) plant transformed with a gene encoding an EPSPS providing the plant tolerance to an application of glyphosate under conditions where this herbicide is effective in killing weeds. The invention particularly concerns an elite transformation event VCO-∅1981-5 comprising the gene construct and means, kits and methods for detecting the presence of the said elite transformation event.
Patent EA-028792-B1 (EA)
Title: System for monitoring and controlling the bacterial count in a confined environment
Inventor: LONGO MATTEO
IPC: A61L9/14
Filed: 2013-07-03
Abstract: A system (1) for monitoring and controlling the bacterial count in a confined environment, comprising an environment identification device (2) arranged to contain information relating to the confined environment; a device (3) for micronizing air-dispersed decontaminant substances arranged to diffuse through a diffuser (9) a decontaminant substance (12) by air and in the form of dry fog, based on the information contained in the environment identification device (2); a detection sensor (4) adapted to detect the concentration of the decontaminant substance (12); an instantaneous bacterial analysis sensor (5) arranged to determine the quantitative and qualitative bacterial concentration; a central server (6) arranged to process data received from the diffuser (9), from the detection sensor (4) and from the instantaneous bacterial analysis sensor (5), so as to identify anomalies with respect to a desired quantitative and qualitative bacterial objective and certify the bacterial result obtained as a result of the diffusion of the decontaminant substance (12).
Patent EA-029813-B1 (EA)
Title: Light-weight design railway rail
Inventor: KHABARDIN VASILY NIKOLAEVICH
IPC: E01B5/02
Filed: 2014-12-02
Abstract: The invention is related to railway building and to mechanical engineering, in particular, to rail design. The invention proposes a light-weight rail having the following structure. The rail base has symmetrical arcuate cut-outs made so that their apexes contact the rail top. The base and the space between the top and the base have supports disposed along the beam, the length of the supports in their base not exceeding the width of sleepers installed in soil. The distance between the lines of symmetry of said supports coincides with spacing of the lines of symmetry of sleepers. Each support has holes between its arcs, the holes centres lying in the symmetry lines of the supports. The rail ends are made to provide the possibility of making a suspended joint, i.e., joint of double-rib fishplates thereto to fasten it with clamping bolts to other rails at the joint place.
Patent EA-028141-B1 (EA)
Title: Method for producing biodegradable, biocompatible tissue-engineered sheets using cultured fibroblasts
Inventor: DANLYBAEVA GAZIZA AYATBEKOVNA
IPC: C12N5/071
Filed: 2015-06-12
Abstract: The invention may be applied either independently, or in complex surgery treatment of patients with deep burn wounds, extended post-traumatic wound defects of skin and soft tissues, osteomyelitis of different geneses and concomitant with soft tissue defects, and also long-time, poorly healed trophic ulcers. The technical objective of the invention is development of method for producing tissue-engineered sheets representing two-layer bio-engineered constructs that comprise underlayer of biodegradable matrix consisting of natural polysaccharides, chitosane and pectin, supplemented with an antioxidant, quercetin, and performing mechanical and supporting functions. A second layer is formed by skin cells, fibroblasts, and represents artificial analogue to a dermal skin layer that can lower risk of rough scar tissue formation. Cell material represents suspension of live cultured fibroblasts of density 50×10cells per 1 cmin nutrient medium with no added xenogenic serum, and it is applied on underlayer surface as suspension and can adhere itself upon matrix surface using centrifugation at 200G (1500 rpm) during 5 to 8 min, so these cells are not cultured. As allogenic material, use is recommended of either human diploid fibroblast strain FECh 2/09 (Innovation Patent No. 25091 of 15.12.2011), or other characterized skin cell culture, or autologous cells obtained from the same patient. Constructive features of transplant performance provide the most beneficial adherence to defect areas and exclude possibility of damage to under- or near-laying tissues. High sorption ability and optimal terms of resorbtion can prevent formation of inflammatory infiltrates and suppuration of wound. Reliability of obtained results was clinically proved. Efficacy in application of tissue-engineered sheets with adhered fibroblasts is provided through non-specific stimulation of epithelium reparation, mainly due to secretion of growth factors, cytokines, and extracellular matrix molecules, which can promote healing, upon wound surface by these cells, while underlayer renders immune-modulation effect. The disclosed method can increase degree of auto transplant engraftment, accelerate epithelisation of perforation spots, and reduce recovery period in both proper and donor wound surfaces.
Patent EA-028584-B1 (EA)
Title: Pyridinyl and fused pyridinyl triazolone derivatives
Inventor: LAWSON JOHN DAVID
IPC: C07D401/14
Filed: 2014-03-10
Abstract: Disclosed are compounds of Formula 1or pharmaceutically acceptable salts thereof, wherein R, R, R, and Rare defined in the specification. The present invention also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain said compounds, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.
Patent EA-034449-B1 (EA)
Title: Device for studying kinetics of dipping samples of tissue with liquid polymeric binders
Inventor: NELYUB VLADIMIR ALEXANDROVICH
IPC: G01N33/36
Filed: 2017-12-28
Abstract: The invention relates to the field of polymer processing, more specifically to the research and optimization of molding conditions of products made of polymeric composite materials (PCM) manufactured using technology such as RTM (ResinToolMolding), LRI (LiquidResinInfusion), RFI (ResinFilmInfusion), more specifically to the researches of steeping of a tissue sample previously laid in closed cavity of measuring cell of device (bench) for studying kinetics of steeping of tissues with various structures and chemical nature in conditions of dampening and filtration. The task is creating a device for studying the kinetics of steeping of tissue samples of various braidings with liquid polymer binders under conditions of different pressure of binder injection. The device for studying the kinetics of steeping of tissue samples with liquid polymer binders consists of a reservoir with a liquid binder, a device for dipping a filler with a binder and a compressor to create injection pressure when giving the binder. Additionally, a measuring cell for a sample of tissue to be examined is placed in the device for dipping a filler with a binder between located in front transparent capillary tube and a catch tank for bleedout. The measuring cell is a construction of two rectangular metal die plates and punch with fluoroplastic jacket with air proof plain rectangular slot between them for placing in it a tissue sample with the possibility of its external compression by punch; insertion holes into the air proof slot of the cell of liquid polymer binder and output of its bleedout are located lateral on the opposite sides of the plates and are equipped with connections to join external tubes. There is also a possibility to adjust the width of front of the binder flow by changing the location along periphery of the tissue sample of compaction elements guiding the binder into the sample. Design of the measuring cell provides for the possibility of heating and creating additional pressure in the process of curing the polymer composite sample, wherein the connections used to insert and output the binder should operate as two-way stopcocks shutting off the binder flow. Operation of the measuring cell is eased due to using fluoroplastic, as the fluoroplastic inert surface substantionally simplifies its pressing after curing the polymer composite sample. The device can be optionally provided with additional devices of various controllable effects on the binder and filler, namely temperature, ultrasound, other physical factors having significant influence on the processes.