baber/WOPTO huggingface dataset:
Patent DK-0759985-T3 (DK)
Inventor: KOUSKOFF V
IPC: A61K48/00
Filed: 1995-05-18
Granted: 2009-04-20
Abstract: A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire of a wildtype control animal. The TCR repertoire of the arthritic animal, albeit limited, is functionally viable. In a preferred embodiment, the invention relates to transgenic arthritic mice wherein arthritis results from (1) a transgenic allele which encodes and expresses TCR  alpha  and  beta  subunits that combine in T lymphocytes of the transgenic animal to form a TCR that recognizes an antigen comprising one or more epitopes of an oligopeptide derived from amino acids 41-61 of bovine pancreatic ribonuclease and/or (2) polypeptide arthritogenic self antigens derived from endogenous proteins. The transgenic arthritic mice of the invention provides an animal model which faithfully mimics rheumatoid arthritis and by which human arthritogenic and therapeutic anti-arthritic compositions are evaluated. Also provided herein are therapeutic oligopeptides derived from the variable regions of the TCRs of the transgenes of the invention and/or from the amino acid sequence of proteins comprising endogenous polypeptide arthritogenic antigens.
Patent DK-0766556-T3 (DK)
Inventor: BECHER FRANK
IPC: A61K8/02
Filed: 1995-06-03
Granted: 2000-03-13
Abstract: PCT No. PCT/EP95/02120 Sec. 371 Date Dec. 6, 1996 Sec. 102(e) Date Dec. 6, 1996 PCT Filed Jun. 3, 1995 PCT Pub. No. WO95/33452 PCT Pub. Date Dec. 14, 1995A volume-expandable, sheet-like application form suitable as an active substance carrier, in particular for oral application, in the form of a film comprising a mixture of fillers, cleansers, cosmetics, or active substances, film formers, and softeners has portions of a highly absorbent hydrogel former which swells on contact with water and assumes several times its original volume.
Patent DK-0777606-T3 (DK)
Inventor: SMEKENS DANIEL P
IPC: B65B55/02
Filed: 1995-08-23
Granted: 2003-07-21
Abstract: A method and an apparatus for aseptically producing, harvesting and packaging a pharmaceutical product. A section of the apparatus includes an aseptic reactor and structure for introducing a reactant thereinto so that a reaction can be conducted for the purpose of producing a pharmaceutical product. The pharmaceutical product is subsequently introduced into a filter/dryer for the purpose of recovering the pharmaceutical product. Thereafter, the filtered/dried pharmaceutical product is delivered to a hammer mill for delumping or a micronizing mill for calibration and sizing the recovered product to produce a final powdered product. Thereafter, the final powdered product is introduced into a dosing device and aseptically introduced into a transportable bin. The small bins are encased inside of a sterile bag for transport and further aseptic handling.
Patent DK-0784476-T3 (DK)
Inventor: LODER CARI
IPC: A61P37/00
Filed: 1995-10-05
Granted: 2003-03-17
Abstract: Method for treating multiple sclerosis or encephalomyelitis by administering to a patient a combination of a tricyclic antidepressant drug and tyrosine or phenylalanine or both.
Patent DK-0784654-T3 (DK)
Inventor: DELONG WILLIAM M
IPC: C08L33/00
Filed: 1995-10-03
Granted: 2003-01-27
Abstract: An asphalt release agent and a method of applying the same, wherein said asphalt release agent comprises a fatty oil as the active ingredient together with a foaming agent, a crosslinked copolymer, an alkalinizing agent and a preservative. The release agent is preferably applied using a pneumatic pump to pump the release agent through an air-inducting nozzle.
Patent DK-0902694-T3 (DK)
Inventor: BOTICH MICHAEL J
IPC: A61M5/24
Filed: 1996-08-20
Granted: 2003-07-28
Abstract: An injection device for administration of fluid medication is provided with a retraction mechanism for safety retracting the injection needle after administration of the injection. The device comprises a barrel for receiving a pre-filled medication cartridge containing a supply of fluid medication and sealed by a slidable plug. A plunger is positioned in the barrel. The plunger includes a rear portion for engaging and puncturing the plug, and for holding the plug at a stationary position as the cartridge is merged into the barrel to administer the injection. The player further includes a formal end for releasing the needle for the needle retraction mechanism when the cartridge has been urged into the barrel after the and of an injection stroke.
Patent DK-0812846-T3 (DK)
Inventor: OBERHAUSER THOMAS
IPC: C07D505/00
Filed: 1997-06-05
Granted: 2001-11-12
Abstract: The invention is concerned with a new process for the preparation of compounds of formula <CHEM>     wherein   R<1>   is trityl, acetyl, tetrahydropyranyl or cyclopentyl; R<2>   is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, lower alkynyl, aryl, aryloxy, aryl-lower alkyl, aryl-lower alkoxy or heterocyclyl or heterocyclyl-lower alkyl; the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl, aryloxy, aryl-lower alkoxy, the heterocyclyl moieties being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, -CONR<21>R<22>, -N(R<22>)COOR<23>, R<22>CO-, R<22>OCO- or R<22>COO-, wherein R<21> is hydrogen, lower alkyl, or cycloalkyl; R<22> is hydrogen or lower alkyl; R<23> is lower alkyl, lower alkenyl or a carboxylic acid protecting group; Y   is -S- and Z is -CH2- or Y   is -CH2- and Z is -O-,  by acylation of a compound of formula <CHEM>  with an activated carboxylic acid derivative of formula <CHEM> wherein R<3> is lower alkyl, and R<1>, R<2>, X, Y, Z have the significance given above; and it is further concerned with compounds of formula III.
Patent DK-0941341-T3 (DK)
Inventor: GARCHON HENRI-JEAN
IPC: C12Q1/6883
Filed: 1997-12-05
Granted: 2007-03-19
Abstract: The present invention concerns, in particular, human flavin-containing monooxygenase 2 (hFMO2), and another human enzyme of the FMO, hFMOx family, their nucleotide and polypeptide sequences. The present invention also concerns vectors for cloning and/or expression containing said nucleotide sequences and cells transformed by these vectors and method for preparing said polypeptides. The invention further concerns methods for selecting compounds and of diagnosing predisposition to pathologies and/or deficiencies related to FMO's and pharmaceutical compositions containing said compounds for treating and/or preventing these pathologies.
Patent DK-1009113-T3 (DK)
Inventor: ILSANKER ANTON
IPC: H04H20/00
Filed: 1998-12-01
Granted: 2001-08-20
Abstract: The matrix (1) in front of the converter circuit (9) provides selective reception from one or more satellites transmitting electromagnetic waves with vertical or horizontal polarization, in lower and upper frequency band. There is a control unit (15) and a data bus for control of several subscriber receivers (13), connectable to an aerial line. The data bus consists of a multimaster bus, over which the receivers can be controlled. Each receiver contains a generator and evaluator of an anti-collision signal, safeguarding single receiver communication with the controller. An Independent claim is also provided for a method of operating the satellite receiver.
Patent DK-0973704-T3 (DK)
Inventor: HOGAN PHILIP JOHN
IPC: C07D401/12
Filed: 1998-03-03
Granted: 2005-01-17
Abstract: A process for the manufacture of: wherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises: (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.
Patent DK-0986413-T3 (DK)
Inventor: PELAEZ RICARDO PALACIOS
IPC: A61M15/08
Filed: 1998-05-26
Granted: 2004-09-20
Abstract: A device for applying a powdered or particulate substance to a mucous membrane in a nostril comprises a tubular body (10) similar to a drinking straw. The tubular body has opposite end parts forming a mouthpiece (11) and a nasal piece (12) to be inserted between the lips and into the nostril, respectively, of a user. The mouthpiece (11) and the nasal piece (12) are interconnected by a bent or a bendable, preferably corrugated part (13). A dose of a powdered or particulate substance arranged within the tubular body (10) is transferred to the nostril when the user blows into the mouthpiece (11). A part of the mouthpiece is preferably deflated or compresses between a pair of fingers (35) of the user. The compressed part (34) is released when the user has started to blow forcefully into the compressed mouthpiece part which is thereby inflated. It has been found that the user will automatically close the connection between the nostrils and the throat by the uvula when blowing.
Patent DK-1007898-T3 (DK)
Inventor: HUG CARL
IPC: F42B12/80
Filed: 1998-08-24
Granted: 2001-10-01
Abstract: The invention relates to a jacketed projectile (100), comprising a tungsten carbide hard core (5) on the front side and an centered, interlocking soft core (8) placed on the hard core (5). A closed air space (6) is located between the front area (5a) of the hard core (5) and the tip of the projectile (4). This projectile configuration provides a very high penetration potential and good dynamic and ballistic properties, enabling the inventive projectiles to be used as munition for police snipers, especially to hit targets located behind a glass.
Patent DK-1080054-T3 (DK)
Inventor: JUUTINEN OSMO
IPC: C05G5/12
Filed: 1999-05-14
Granted: 2004-04-05
Abstract: The invention relates to a novel process for the preparation of fertilizers, a so-called multiple-suspension process, according to which two or more raw-material suspensions of different compositions are prepared in separate reactors or reactor systems coupled in parallel. These raw-material suspensions are fed into a granulator separately or combined together immediately before the granulation, and thus the mutual reactions of the raw-materials fed into the different suspensions, and consequently also the salt composition of the product, will be different from those obtained when the same product is prepared by the normal single-suspension process.
Patent DK-1112412-T3 (DK)
Inventor: ALBRITTON JAMES R
IPC: B60R19/00
Filed: 1999-08-12
Granted: 2008-03-03
Abstract: An energy absorbing system with one or more energy absorbing assemblies is provided to reduce or eliminate the severity of a collision between a moving motor vehicle and a roadside hazard. The energy absorbing system may be installed adjacent to a roadside hazard such as the end of a concrete barrier facing oncoming traffic. The energy absorbing system preferably includes at least one energy absorbing element. A sled assembly is also provided with a cutter plate such that a collision by the motor vehicle with one end of the sled assembly will result in the cutter plate tearing or ripping the energy absorbing element to dissipate energy from the motor vehicle collision. The configuration and number of energy absorbing assemblies and the configuration and number of energy absorbing elements may be varied depending upon the intended application for the resulting energy absorbing system.
Patent ES-2247963-T3 (ES)
Inventor: LOTH ROBERT
IPC: B27L11/02
Filed: 2000-01-11
Granted: 2006-03-16
Abstract: A system for cleaning cutting cylinders, e.g. milling heads, shredders etc., has the cutting cylinder held on rollers (11.1, 11.2) with at least one roller powered to rotate the cylinder past cleaning jets (16,17) and past cleaning brushes (14,15) to remove any debris. The cleaning process is performed inside a closed housing into which the cutting cylinder is loaded using a transfer system.
Patent ES-2338629-T3 (ES)
Title: Deerivados de aminoquinazolina (tiona) sustitutos o sales de los mismos, intermedios de los mismos y controladores de plagas y un metodo para el uso de los mismos.
Inventor: UEHARA MASAHIRO
IPC: A01N43/54
Filed: 2000-11-02
Granted: 2010-05-11
Abstract: Un derivado de aminoquinazolinona sustituido o una sal del mismo que se selecciona entre el grupo constituido por: 3,4-dihidro-3-[(3-piridinilmetilideno)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 22), 3,4-dihidro-1-metoxicarbonil-3-[(3-piridinilmetilideno)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 178,6), 3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Com- puesto 200), clorhidrato de 3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinanolinona (Compuesto 437), sulfato de 3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 438), 1-benzoil-3,4-dihidro-3-[(3-piridinilmetil)amino]-8-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 440), 1-(3-clorobenzoil)-3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 491), 1-acetil-3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 448), 3,4-dihidro-1-propionil-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazo- linona (Compuesto 452), 1-butiril-3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 456), 3,4-dihidro-1-isobutiril-3-[(3-piridinilmetil)amino]-6-(1,2,2,2-tetrafluoro-1-(trifluorometil)etil)-2(1H)-quinazo- linona (Compuesto 444), 1-bromoacetil-3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 489), 3,4-dihidro-1-metoximetilcarbonil-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 490), 3,4-dihidro-1-metoxicarbonil-3-[(3-piridinilmetil)amino]-8-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-qui- nazolinona (Compuesto 494), 3,4-dihidro-1-etoxicarbonil-3-[(3-piridinilmetil)amino]-8-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quina- zolinona (Compuesto 492) y 1-t-butoxicarbonil-3,4-dihidro-3-[(3-piridinilmetil)amino]-6-[1,2,2,2-tetrafluoro-1-(trifluorometil)etil]-2(1H)-quinazolinona (Compuesto 493).
Patent ES-2200803-T3 (ES)
Inventor: MAULEON JEAN-LOUIS
IPC: C07C9/00
Filed: 2000-12-06
Granted: 2004-03-16
Abstract: Alkylation of isobutane comprises: (a) reacting an isobutane-rich feed (3) with a light-olefin-rich feed (2); (b) passing the effluent to a fractionation column (6); (c) recycling the isobutane-rich fraction (9) to the alkylation reactor; and (d) purifying the n-butane-rich fraction (8) to reduce its C5+ content, passing it through an isomerization reactor (16) to convert n-butane to isobutane, and recycling it to the fractionation column. Alkylation of isobutane with olefins comprises: (a) reacting an isobutane-rich feed (3) with a light-olefin-rich feed (2) in an alkylation reactor; (b) passing the effluent to a fractionation column (6) to obtain an alkylate-rich fraction (7), an n-butane-rich fraction (8) and an isobutane-rich fraction (9); (c) recycling the isobutane-rich fraction to the alkylation reactor; and (d) purifying the n-butane-rich fraction to reduce its C5+ content to 5 wt.% or less, passing it through an isomerization reactor (16) to convert n-butane to isobutane, and recycling it to the fractionation column. An Independent claim is also included for apparatus for alkylating isobutane with olefins, comprising: an alkylation reactor (1); a fractionation column (6) with a bottom outlet for alkylate, a middle outlet for n-butane and a top outlet for isobutane; an isobutane recycle line (9); a rectifier (12) for removing C5+ hydrocarbons from the n-butane fraction; an isomerization reactor (16) for converting n-butane to isobutane; and an isomerizate recycle line (21).
Patent ES-2310516-T3 (ES)
Inventor: RICCI CHARLIE
IPC: A61K47/08
Filed: 2000-03-20
Granted: 2009-01-16
Abstract: Disclosed are methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms which comprise the in situ embolization of blood vessels associated with the aneurysmal sac prior to placement of an endovascular prostheses in the abdominal aorta. Embolization of the blood vessels is achieved by injection of either a biocompatible polymer or prepolymer fluid composition into these vessels in a sufficient amount such that upon in situ solidification of this composition, blood circulation through these blood vessels and the aneurysmal sac ceases.
Patent ES-2276679-T3 (ES)
Title: Aparato para enfriar.
Inventor: GARCIA SR RAUL JASSO
IPC: F28C3/06
Filed: 2000-03-23
Granted: 2007-07-01
Abstract: Aparato para enfriar rápidamente una corriente gaseosa caliente, que comprende: (i) un primer medio (10) de conducción para transportar dicho gas caliente desde una fuente corriente arriba hasta una ubicación corriente abajo; (ii) un medio de obstrucción del flujo situado dentro de dicho medio de conducción para crear una zona de baja presión en dicha corriente gaseosa caliente inmediatamente corriente abajo de dicho medio de obstrucción; (iii) un segundo medio (12) de conducción situado corriente abajo de dicho medio de obstrucción del flujo, intersecándose dicho segundo medio de conducción con dicho primer medio de conducción en una tangente suya y en un ángulo respecto a él, estando dicho segundo medio de conducción adaptado para inyectar un fluido de enfriamiento tangencialmente en dicha corriente gaseosa caliente para fluir circunferencialmente alrededor de la superficie interior de dicho primer medio de conducción y para llenar dicha zona de baja presión de dicha corriente gaseosa caliente y contactar con la cara de corriente abajo de dicho medio de obstrucción del flujo; y (iv) un medio interfacial en dicha cara de corriente abajo de dicho medio de obstrucción del flujo para proporcionar una interfaz afilada entre dicha corriente gaseosa caliente y dicho fluido de enfriamiento.
Patent ES-2256007-T3 (ES)
Inventor: BISEROD HANS B
IPC: F15B15/22
Filed: 2000-06-02
Granted: 2006-07-16
Abstract: A translation and locking mechanism for a projectile that is lying in a standby position within a rocket motor in a missile, wherein the projectile is translated with respect to the rocket motor by means of a pyrotechnic charge before the rocket motor is ignited. The rear end of the projectile includes at least one radially spring biased lock and the front part of the rocket motor includes an internal circumferential groove that the at least one lock snaps into when the at least one lock is translated to the groove.
Patent ES-2323666-T3 (ES)
Inventor: RANOUX CLAUDE
IPC: C12N5/075
Filed: 2000-04-18
Granted: 2009-07-23
Abstract: A method of fertilization and culture comprises: 
providing a fertilization and culture container having an orifice and a main chamber for fertilization and culture and the microchamber for inspection and retrieval of one or more embryos, and resealable closure for selectively opening and closing the orifice; filling the container with the culture medium and introducing one or more oocytes and sperm into the culture medium, and thereafter closing the orifice; incubating the closed container to allow fertilization and culture of the oocytes; allowing migration of the resulting embryo or embryos into the microchamber; and retrieving one or more embryos from the microchamber with a catheter or pipette.
Patent ES-2226869-T3 (ES)
Title: Composicion a base de particulas magneticas.
Inventor: BAKER MATTHEW JOHN
IPC: C12N15/10
Filed: 2000-06-30
Granted: 2005-04-01
Abstract: Composición de partículas magnéticas que consiste en un material magnético combinado con un intercambiador de iones cargado negativamente, en la cual las partículas presentan un diámetro entre 20 m (micras) y 1 mm y donde la composición se forma por medio de mezclado de un polvo de un material magnético con un polvo de un intercambiador de iones cargado negativamente.
Patent ES-2206264-T3 (ES)
Inventor: SIMMERER HELMUT
IPC: G05B19/42
Filed: 2000-05-15
Granted: 2004-05-16
Abstract: With a method for producing the control module, the control module is assembled from a number of program modules which are designed for one basic function in each case. Each program module has an interface of an interface type defined by the respective basic function. A functional connection is preferably only established between two program modules if the two program modules have mutually corresponding interfaces of the same interface type. The method permits simple, quick and in particular rule-based automatic production of the control module of a control system for controlling a plant component.
Patent ES-2225179-T3 (ES)
Inventor: KALLANDER CLAS
IPC: C12Q1/42
Filed: 2000-06-16
Granted: 2005-03-16
Abstract: A reverse transcriptase (RT) assay kit for analysis of RT activity in biological samples is described. The kit comprises solid phase bound prA and/or pdA template(s) obtainable by contacting a polystyrene-based solid phase with a 1-methylimidazole-containing coupling solution, and RT-type adapted assay components selected from a buffer, divalent metal ion, chelator, polyamine, RNase inhibitor, reducing agent, salt, stabilizing agent, and detergent, and deoxynucleotide triphosphate, primer, protective agent and concentrated washing buffer, and optionally lyophilized reference enzyme(s), and further optionally lyophilized alkaline phosphatase conjugated anti-BrdU monoclonal antibody, alkaline phosphatase substrate buffer and alkaline phosphatase substrate, and written instructions for use of the assay kit. Further, a method and a use of the assay kit for the qualitative and quantitative analysis of RT activity in a biological sample, optionally followed by evaluation of the status of a RT activity related disorder or disease based on the result of the analysis of the RT activity, are disclosed.
Patent ES-2200944-T3 (ES)
Inventor: VOLKER WOLFGANG
IPC: B22F3/11
Filed: 2000-09-12
Granted: 2004-03-16
Abstract: The invention relates to a method for foaming metal powder. The metal powder is mixed with a foaming agent. The mixture consisting of the metal powder and the foaming agent is compacted to form a blank which is subsequently foamed. Before foaming, the blank (2) is supplied to an extruder (1). A refrigerated gas is at least temporarily supplied to the extruder.
Patent ES-2190991-T3 (ES)
Inventor: STIENSTRA STOFFER
IPC: A01N1/02
Filed: 2000-10-23
Granted: 2003-09-01
Abstract: A method for the production of stabilized platelets, comprises the steps of: (i) pre-activating platelets, to induce the formation of microvesicles; (ii) contacting the pre-activated platelets with a carbohydrate, whereby the carbohydrate is incorporated into the platelets; and (iii) drying the thus-loaded platelets.