Patent SG-11201804803W-A (SG)
Title: Multi-specific antibody molecules having specificity for tnf-alpha, il-17a and il-17f
Inventor: ADAMS RALPH
IPC: C07K16/18
Filed: 2016-12-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 1111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111 (43) International Publication Date 22 June 2017 (22.06.2017) (10) International Publication Number WO 2017/102830 Al WIPO I PCT (51) International Patent Classification: C07K 16/24 (2006.01) C07K 16/18 (2006.01) (21) International Application Number: PCT/EP2016/080979 (22) International Filing Date: 14 December 2016 (14.12.2016) English English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) of inventorship (Rule 4.17(iv)) Published: with international search report (Art 21(3)) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 1522391.0 18 December 2015 (18.12.2015) GB (71) Applicant: UCB BIOPHARMA SPRL [BE/BE]; 60, Allee de la Recherche, 1070 Brussels (BE). (72) Inventors: ADAMS, Ralph; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). BHATTA, Pallavi; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). DAVE, Emma; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB) HEYWOOD, Sam Philip; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). HUMPHREYS, David Paul; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). MAR- SHALL, Diane; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). SHAW, Stevan Gra- ham; c/o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). LIGHTWOOD, Daniel, John; c/o IPD, UCB Celltech, 208 Bath Road, Slough, Berkshire SL1 3WE (GB). (74) Agent: BLANCHARD, Amanda; c/o UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). W O 20 17 / 10 2830 Al (54) Title: MULTI-SPECIFIC ANTIBODY MOLECULES HAVING SPECIFICITY FOR TNF-ALPHA, IL-17A AND IL-17F (57) : The invention relates to multi-specific antibody molecules having specificity for TNF alpha, IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.