baber/WOPTO huggingface dataset:
Patent DE-69427974-D1 (DE)
Inventor: HAMERS RAYMOND
IPC: C07K16/00
Filed: 1994-04-28
Granted: 2001-09-20
Abstract: A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an example DNA sequence encoding the antibody or (functionalized) fragment thereof, wherein the antibody or (functionalized) fragment thereof is derived from a heavy chain immunoglobulin of Camelidae and is devoid of light chains, and wherein the lower eukaryotic host is a mould, preferably belonging to the genera Aspergillus or Trichoderma, or a yeast, preferably belonging to the yeast genera Saccharomyces, Kluyveromyces, Hansenula, or Pichia. The heavy chain fragment can contain at least the whole variable domain. A complementary determining region (CDR) different from the CDR belonging to the natural antibody ex Camelidae can be grafted on the framework of the variable domain of the heavy chain immunoglobulin. The catalytic antibodies can be raised in Camelidae against transition state molecules. The functionalized antibody or fragment thereof can comprise a fusion protein of both a heavy chain immunoglobulin from Camelidae or a fragment thereof and another polypeptide, e.g., an enzyme, preferably an oxido-reductase. Also provided are new products obtainable by a process as described, and compositions containing a product produced by a process as described, which composition may contain a new product as provided.
Patent DE-69431620-D1 (DE)
Inventor: CHEDID LOUIS
IPC: A61P9/00
Filed: 1994-03-21
Granted: 2002-12-05
Abstract: PCT No. PCT/FR94/00307 Sec. 371 Date Nov. 13, 1995 Sec. 102(e) Date Nov. 13, 1995 PCT Filed Mar. 21, 1994 PCT Pub. No. WO94/21275 PCT Pub. Date Sep. 29, 1994A therapeutical composition for use in humans, comprising a combination of at least one natural or recombinant and preferably human cytokine with at least one muramyl peptide selected from those which, when administered in vivo together with an interferon, also induce an increased in vivo production of an interleukin-1 receptor antagonist IL-1 RA, but preferably do not induce any increase in TNF, IL-8 and IL-1 cytokines. Said composition is useful for antiviral and antitumoral therapies and/or for promoting restoration of the haematopoietic system, particularly in individuals with a weakened immune system.
Patent DE-69434217-D1 (DE)
Inventor: OLIVERA BALDOMERO M
IPC: C12N15/12
Filed: 1994-06-27
Granted: 2005-02-03
Abstract: Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.
Patent DE-69434244-D1 (DE)
Inventor: CONNORS THOMAS
IPC: A61P35/00
Filed: 1994-11-04
Granted: 2005-03-03
Abstract: PCT No. PCT/GB94/02423 Sec. 371 Date Jul. 1, 1996 Sec. 102(e) Date Jul. 1, 1996 PCT Filed Nov. 4, 1994 PCT Pub. No. WO95/12678 PCT Pub. Date May 11, 1995A system is disclosed which comprises: (i) a viral vector comprising a nucleotide sequence encoding a nitroreductase, which nitroreductase is capable of converting a prodrug into a cytotoxic drug; and (ii) a prodrug capable of being converted into a cytotoxic drug by the nitroreductase encoded by the vector. The disclosed invention also includes methods for killing cancerous and/or non-cancerous cells using the system described above. Included in the invention are methods for killing cells in vitro by introducing a vector encoding a nitroreductase into the cells, and then by providing a prodrug to the cells growing in vitro. Also included are methods in which cancerous and/or non-cancerous cells are killed in vivo in an animal or human by administering the vector and prodrug directly to cells of the animal or human. The invention further includes methods in which cancerous and/or non-cancerous cells are killed in vivo in an animal or human, by introducing a viral vector encoding a nitroreductase into animal or human cells growing in vitro so that the nitroreductase is produced in the cells, administering the cells to an animal or human subject, and then administering a prodrug to the animal or human, where it is converted into a cytotoxic agent in nitroreductase-containing cells of the animal or human.
Patent DE-69505376-D1 (DE)
Inventor: VAN NOORT JOHANNES
IPC: C12N15/09
Filed: 1995-06-08
Granted: 1998-11-19
Abstract: The present invention discloses the first medical use of alpha B crystallin or derivatives thereof in the field of auto-immune diseases, particularly multiple sclerosis. It also discloses diagnostic methods and tools therefor based upon alpha B crystallin for the detection of multiple sclerosis. Human alpha B crystallin is a known protein in itself, known to be present in the eye and in small amounts in the white matter of the nerve system, which is affected by multiple sclerosis. By using a novel and inventive approach to test for ability to induce auto-immunity, alpha B crystallin has been shown by the present invention to be an important auto-antigen. Such methods are also part of the invention.
Patent DE-69509242-D1 (DE)
Inventor: BRADY MICHAEL
IPC: H01L23/66
Filed: 1995-08-08
Granted: 1999-05-27
Abstract: The present invention is a novel thin and flexible radio frequency (RF) tag that comprises a semiconductor circuit that has logic, memory, and radio frequency circuits, connected to an antenna with all interconnections placed on a single plane of wiring without crossovers. The elements of the package (substrate, antenna, and laminated covers) are flexible. The elements of the package are all thin. The tag is thin and flexible, enabling a unique range of applications including: RF ID tagging of credit cards, passports, admission tickets, and postage stamps. <IMAGE>
Patent DE-69509340-D1 (DE)
Inventor: TOMMA KAUKO
IPC: B65H18/14
Filed: 1995-05-19
Granted: 1999-06-02
Abstract: The invention concerns a method in winding of a web, wherein the web (W) is wound onto a spool (14) a support of a support roll (16) while passed through a nip (N) formed between the support roll (16) and the roll (15) that is being produced. The spool (14) is supported at least partly. The spool (14) / the roll (15) is supported and/or loaded by means of a device (20) whose position can be shifted. At the initial stages of the winding, the loading/supporting unit/units (24) of said device (20) is/are shifted substantially in the plane passing through the axes of the support roll (16) and of the roll (15) that is being produced so as to load and/or to support the roll (15) that is being produced in the winding position. When the winding makes progress, the loading/supporting unit/units (24) of the device (20) is/are shifted downwards substantially along a path parallel to the circumference of the roll (15), and, at the final stages of the winding, the roll (15) that is being produced is supported by means of said unit (24) from underneath. The invention also concerns a device in winding of a web for carrying out the method. The device (20) is fitted to be used when a web (W) is wound onto a spool (14) on support of a roll (16) while passed through a nip (N) formed between the roll (16) and the roll (15) that is being produced, which spool (14) is supported at least partly by a support member placed in the centre of the spool (14). The device (20) comprises a unit (24) for supporting the spool (14) and for loading the roll (15). The unit (24) is fitted as a combined loading/supporting and surface-drive member. The device (20) comprises means for shifting the unit (24) substantially in the plane passing through the axes of the support roll (16) and the roll (15) that is being produced and substantially along a curved path parallel to the circumference of the roll (15). <IMAGE>
Patent DE-69522584-D1 (DE)
Inventor: WONG MING
IPC: A61K9/14
Filed: 1995-06-09
Granted: 2001-10-11
Abstract: This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.
Patent DE-69524490-D1 (DE)
Inventor: GELB DAVID A
IPC: A61C1/08
Filed: 1995-05-18
Granted: 2002-01-24
Abstract: A radiographic guide (40) for accurately positioning a proposed implant in the jawbone of a patient. The guide (40) has a lower rod portion (44) configured to fit within a pilot bore (70) drilled in the jawbone (12) and an upper cap (48) configured to correspond to the shape and dimensions of a commercially available implant. The rod portion (44) may include depth markings (46) to indicate distances from a selected reference point. Placing a guide into the pilot bore, visually inspecting the cap of the guide, and taking an x-ray using a method to give anatomically correct distances gives an indication of the appearance, probable position and angulation of the proposed implant prior to the implantation of the implant into the jawbone. <MATH>
Patent DE-69526096-D1 (DE)
Inventor: FISHMAN PNINA
IPC: A61K35/16
Filed: 1995-09-22
Granted: 2002-05-02
Abstract: A substance secreted or shed by muscle cells and white blood cells is disclosed. This novel substance is active in inhibiting proliferation of tumor cells and proliferation of stimulated lymphocytes. The substance does not inhibit proliferation of normal cells. This substance is used in accordance with the invention for treatment or prevention of cancer and the level of said substance in a body fluid or in a fluid conditioned by the growth therein of cells withdrawn from the individual, is used for the diagnosis of cancer or the level of risk of the individual of developing cancer.
Patent DE-69527053-D1 (DE)
Inventor: GLASE ANN
IPC: C07D277/82
Filed: 1995-02-16
Granted: 2002-07-18
Abstract: Naphthalamides are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents for the treatment of disorders which respond to dopaminergic blockade including psychotic depression, substance abuse, and compulsive disorders.
Patent DE-69535730-D1 (DE)
Inventor: STONE PAUL A
IPC: B21B13/00
Filed: 1995-12-18
Granted: 2008-04-17
Abstract: The invention is concerned with a method of forging a part of a predetermined shape from a workpiece comprising the steps of: 
radially closing opposed forging dies such that the forging dies move radially inward in a predetermined direction to contact the workpiece wherein the opposed forging dies define a cavity therebetween of the predetermined shape of the resulting part; 
applying axial and radial force to the workpiece with the radially closing forging dies, said applying step including the step of generating compressive and shear stresses within the workpiece such that the workpiece deforms outwardly to the predetermined shape defined by the opposed forging dies; and 
structurally reinforcing the opposed forging dies during the application of compressive and shear forces with a die housing which receives and circumferentially encompasses the opposed forging dies during the forging process.
Patent DE-69605383-D1 (DE)
Inventor: COLSON WENDELL
IPC: E06B9/323
Filed: 1996-04-24
Granted: 2000-01-05
Abstract: A fabric for use in an architectural covering device includes a plurality of elongated vanes preferably of tubular configuration having a pair of flaps extending longitudinally along the entire length of the vane. A continuous face sheet material has elongated folds at spaced intervals that are secured along the flaps of the vanes so as to pivotally connect the vanes to the face sheet material at predetermined spaced intervals. The fabric is adapted to be supported with an operational system in an architectural opening so that if the vanes are suspended vertically they are slidably movable laterally of the window opening and pivotally movable about vertical longitudinal axes to extend and retract as well as open and close the covering. An apparatus and method for forming the fabric is also disclosed as well as systems for finishing the endmost vanes in the fabric.
Patent DE-69610266-D1 (DE)
Inventor: HENSON T
IPC: B60N2/30
Filed: 1996-01-25
Granted: 2000-10-19
Abstract: A vehicle seat integrated to selectively provide an adult seat in an adult seat mode and a child's seat in a child seat mode, the child's seat including a child's seat belt assembly including a pair of shoulder belts extending from the cushioned child's seat back over the shoulders of a child in a sitting position on the cushioned child's seat. Each of the shoulder belts when the child's seat belt assembly is in a restraint condition including a generally straight portion which extends forwardly from a position rearwardly of a support surface provided by the child's seat back through a space in the cushioned child's seat back accommodating the same to a position adjacent the child's shoulder. The child's seat belt assembly is constructed and arranged to automatically accommodate any particular child within a nominal size range between a 20-pound child and a 60-pound child without the straight portions having any appreciable forwardly and upwardly extent even for a 60-pound child or any appreciable ear interference even for a 20-pound child. The child's seat belt assembly is constructed and arranged to accomplish the aforesaid automatic accommodation by restricting the straight portions to extend forwardly from the support surface automatically from progressively lower levels at progressively greater angles to the horizontal as the particular child held in the restraint condition of the child's seat belt assembly is of progressively diminishing size within the range.
Patent DE-69610323-D1 (DE)
Inventor: JOHNSON EDWARD STEWART
IPC: A61K9/00
Filed: 1996-08-16
Granted: 2000-10-19
Abstract: In one embodiment, this invention relates to a pharmaceutical composition for oral administration consisting essentially of a gelatin at a concentration up to 5% by weight as a carrier, a solvent, and, as an active ingredient, a dopamine agonist. Alternatively, the invention relates to a composition that takes the form of a solid, unitary fast-dispersing dosage form comprised of a network of an active ingredient after and a water-soluble or water dispersible matrix forming agent or carrier which is inert towards the active ingredient after subliming solvent from the composition in the solid state. The dosage is designed to completely disintegrate within 1 to 30 seconds of being placed in the oral cavity. Compositions which further comprise an anti-emetic and/or an opioid antagonist are also provided herein.
Patent DE-69612540-D1 (DE)
Inventor: ENDOU HITOSHI
IPC: A61K31/4164
Filed: 1996-12-20
Granted: 2001-05-23
Abstract: The present invention is directed to a pharmaceutical composition comprising a hydantoin derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof <CHEM> wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group, and a pharmaceutically acceptable carrier or diluent. The above mentioned hydantoin derivative has an action of eliminating the active oxygen and the free radicals. Accordingly, it is useful for preparing a pharmaceutical agent for treating a variety of diseases in which active oxygen and free radicals are participated such as myocardial infarction, reperfusion disturbance, autoimmune diseases, fibrosis, pulmonary diseases, dermatological diseases, arthropathy, side effects of anticancer agents, radiation diseases, septic shock, inflammatory diseases and cataract.
Patent DE-69614013-D1 (DE)
Inventor: BATES IAN RICHARD JOSEPH
IPC: B60W10/10
Filed: 1996-02-07
Granted: 2001-08-30
Abstract: A control system and method for a semi-automatic mechanical transmission system (10) is provided for sensing rolling start conditions (OS > REF, GR = N, (CLUTCH MANUAL DISENGAGED = TRUE)) and upon sensing such conditions, allowing operator request for a direct shift into an appropriate rolling start gear ratio (GRRS) determined as a function of current and/or expected output shaft speed (GRRS ESIDLE/OS). <IMAGE>
Patent DE-69617223-D1 (DE)
Inventor: DOMJAN GYULA
IPC: G01N21/35
Filed: 1996-04-29
Granted: 2002-01-03
Abstract: PCT No. PCT/HU96/00024 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed Apr. 29, 1996 PCT Pub. No. WO96/34272 PCT Pub. Date Oct. 31, 1996A method and apparatus for qualifying an object. Several characteristic values of the object are determined and arranged in a sequence in a polar coordinate system having an origin. At least one quality point is determined as the center of gravity on the basis of the positions of the characteristic values in the polar coordinate system. The object is qualified according to the position of the quality point in the polar coordinate system. In determining the quality point, the characteristic values are taken into account by weighting with their distances from the origin of the polar coordinate system.
Patent DE-69629171-D1 (DE)
Inventor: TSCHAUNER TRACY V
IPC: F16K17/20
Filed: 1996-11-21
Granted: 2003-08-28
Abstract: An improved hydraulic fuse (110) to control hydraulic fluid flow through the fuse comprising an outer body; an annular metering body cylinder within the outer body and defining a bore, and a flow control port, whereby a flow path A is defined between the outer body and the metering body cylinder and to the port (58); a piston slidable longitudinally (14) in the bore to control flow through the port (58); first and second flow control members which are relatively slidable longitudinally in the outer body, and in the paths of fluid flow to the port, and to the piston (14); a threshold spring urging the first member in one direction longitudinally and a metering spring (11) urging the second member in the opposite direction longitudinally; the members and springs cooperating to effect forward flow to the flow control port along path A as forward flow increases to level at which a portion of the flow is diverted to a path B to act on the piston (14), causing the piston (14) to move toward the flow control port (58) and to close the port (58). <IMAGE>
Patent DE-69629574-D1 (DE)
Inventor: HOECK JAMES E VAN
IPC: A61L31/04
Filed: 1996-10-08
Granted: 2003-09-25
Abstract: A hollow spinal spacer for engagement within a disc space between adjacent vertebrae. The spacer comprises a convexly curved anterior surface and a posterior wall having a generally flat posterior surface, and two lateral walls integrally connected between said anterior wall and said posterior wall to define a chamber. The walls define a superior vertebral engaging face having a first opening in communication with said chamber and an inferior vertebral engaging face having a second opening in communication with said chamber. The spacer is configured as a single piece structure that is sized and shaped to fill the disc space. <IMAGE>
Patent DE-69632529-D1 (DE)
Inventor: BERLIET JEROME
IPC: C08K5/00
Filed: 1996-03-07
Granted: 2004-06-24
Abstract: The present invention relates to a polyamide-based composition used for the manufacture of moulded components exhibiting high resistance to attack by light and/or weathering. The invention more particularly relates to compositions comprising a thermoplastic matrix based on semi-crystalline polyamide, a black pigment and optionally reinforcing fillers. This composition is characterized by the presence of thermally stabilizing additives, in combination with a black pigment comprising at least one black pigment of inorganic origin and with at least additives which decrease the effect of radiation on the degradation of the polymeric matrix. The compositions of the invention exhibit improved stability in their properties under the effect of light and/or weathering, for example similar to that of polyester.
Patent DE-69638162-D1 (DE)
Inventor: GROTENDORST GARY R
IPC: C12N5/077
Filed: 1996-05-31
Granted: 2010-05-27
Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF- beta  responsive element upstream of the polynucleotide encoding CTGF structural gene.
Patent DE-69713163-D1 (DE)
Inventor: POTTER ANDREW
IPC: C07D205/04
Filed: 1997-07-15
Granted: 2002-07-11
Abstract: PCT No. PCT/GB97/01915 Sec. 371 Date Dec. 16, 1998 Sec. 102(e) Date Dec. 16, 1998 PCT Filed Jul. 15, 1997 PCT Pub. No. WO98/02417 PCT Pub. Date Jan. 22, 1998Process for obtaining an enantiomerically enriched N-acylazetine-2-carboxylic acid by selectine crystallization of a diastereoisomeric salt formed by relcting an enantiomer of the N-acylazetidine-2-carboxylic acid and an enantiomer of 1-phenylethylamine.
Patent DE-69714327-D1 (DE)
Inventor: LINDQUIST JEFFREY S
IPC: C09J153/02
Filed: 1997-03-26
Granted: 2002-09-05
Abstract: A hot melt adhesive composition comprising from about 5% to about 15% by weight of at least one radial styrene-isoprene-styrene block copolymer having the general configuration (pS-pI-pB)nX wherein n is a number greater than 2, said block copolymer having a molecular weight from about 90,000 to about 380,000, and preferably from about 100,000 to about 250,000, and a styrene content from about 15% to about 35% by weight, and preferably from about 20% to about 30% by weight; up to about 10% of a compatible polymer, wherein the total polymer content does not exceed 15%; from about 30% to about 60% by weight of at least one compatible tackifying resin; from about 20% to about 40% by weight of at least one compatible plasticizer; and from about 0.1% to about 2% by weight stabilizer.
Patent DE-69722963-D1 (DE)
Inventor: CATALDO C
IPC: C08J3/20
Filed: 1997-08-13
Granted: 2003-07-24
Abstract: The invention is a method of making a controlled release device that is free of defects. According to one aspect of the present invention, a method has the steps of first combining an active chemical with a dried carrier into a bound friable mixture followed by combining the bound friable mixture with a polymer preform prior to forming a device. According to another aspect of the present invention, a method has the steps of heating and mixing a casting urethane with an active chemical into a first solution, heating and mixing a trialkanolamine with a soft segment cross-linker into a second solution, and mixing the two solutions. A further aspect of the present invention is a composition of a casting urethane.
Patent DE-69726433-D1 (DE)
Inventor: HUNT JOHN
IPC: B65D85/66
Filed: 1997-09-08
Granted: 2004-01-08
Abstract: An edge protector for the edges of roll shaped articles, e.g. pallets, reeled steel and paper products is made from an elongated sheet (10) of plastics material, the sheet having an indentation (11) extending longitudinally along a major surface of the sheet and extending only partially into the thickness of the sheet. The indentation (11) divides the sheet into webs (12, 13) which are folded into an L-shape.