baber/WOPTO huggingface dataset:
Patent DE-69314183-T2 (DE)
Inventor: BOYLE FRANCIS THOMAS
IPC: A61K31/519
Filed: 1993-11-04
Granted: 1998-01-15
Abstract: PCT No. PCT/GB93/02281 Sec. 371 Date Jun. 28, 1995 Sec. 102(e) Date Jun. 28, 1995 PCT Filed Nov. 4, 1993 PCT Pub. No. WO94/11354 PCT Pub. Date May 26, 1994The invention relates to tricyclic compounds of formula (I)    <IMAGE>  (I)  wherein R1 is hydrogen, amino, (1-4C)alkyl, (1-4C)alkoxy, hydroxy-(1-4C)alkyl or fluoro-(1-4C)alkyl; R2 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, hydroxy-(2-4C)alkyl, halogeno-(2-4C)alkyl or cyano-(1-4C)alkyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and R3 includes a group of the formula -NHCH(CO2H)-A1-Y1 wherein A1 is (1-6C)alkylene and Y1 is carboxy, tetrazol-5-yl, N-[(1-4C)alkylsulphonyl]carbamoyl, N(phenylsulphonyl)carbamoyl, tetrazol-5-ylthio, tetrazol-5-ylsulphinyl or tetrazol-5-ylsulphonyl; or pharmaceutically-acceptable salts or esters thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-cancer agents.
Patent DE-69318320-T2 (DE)
Inventor: EDEN JAMES
IPC: A23L5/20
Filed: 1993-02-01
Granted: 1998-12-24
Abstract: A steam-stripping process suitable for the removal of impurities from polysaccharides, including soluble starch hydrolysates, is disclosed herein. This process may be used in combination with other purification processes, such as ultrafiltration, ion exchange processes or treatment with activated carbon, as well as with a bleaching process. Soluble starch hydrolysates may also be purified by a combination of ultrafiltration and bleaching or by a combination of activated carbon treatment and bleaching. In these processes, the polysaccharide or the soluble starch hydrolysate that is produced is bland in flavor, free of off-odor, optionally, lighter or white in color and suitable for use in food systems requiring these characteristics. Other purification process combinations which are disclosed for removal of undesirable flavors, odors and colors from polysaccharides include:     1. Ultrafiltration and carbon treatment;   2. Ultrafiltration and steam-stripping;   3. Steam-stripping and carbon treatment;   4. Ion exchange treatment and ultrafiltration;   5. Ion exchange treatment and steam-stripping; and   6. Ion exchange treatment and carbon treatment.   A bleaching process may precede any of these processes. If ozone or a peroxide is employed, the bleaching step may follow any of these processes. Any of the processes may be combined with other processes disclosed herein to provide additional purification measures. The processes are particularly useful for purification of low molecular weight soluble polysaccharide hydrolysates, such as dextrins. These purified polysaccharides are used to improve foods and pharmaceutical products.
Patent DE-69319340-T2 (DE)
Inventor: BITOWFT BRUCE
IPC: A61F13/49
Filed: 1993-04-26
Granted: 1999-01-21
Abstract: In a process of making an absorbent article (351) such as a sanitary napkin or a disposable diaper, hydrophilic fibers and crimped or coiled synthetic fibers are supplied in a single fiberboard to a defiberising means such as a hammermill (322). The process results in a homogeneous and resilient blended absorbent core that can be produced using a single defiberising unit. The crimped or coiled fibers pass through the defiberising means without their two- or three-dimensional structure being adversely affected at a relatively low defiberisation energy.
Patent DE-69328585-T2 (DE)
Inventor: BOMBARDELLI EZIO
IPC: C07D459/00
Filed: 1993-06-01
Granted: 2001-01-04
Abstract: Salts of a pharmacologically active, naturally occurring or synthetic alkaloids, or alkaloid derivatives and a phosphatidic acid are provided, which preferably have the formula <CHEM>  wherein   Alk   represents a cation derived from said pharmacologically active, naturally occurring or synthetic alkaloid, or alkaloid derivative, PA   represents a phosphatidic acid or a mixture of different phosphatidic acids, and x:y   is from 2:1 to 1:2.   The therapeutic use of the salts of the invention inthe treatment of syndromes affecting the elderly, particularly conditions that are related to changes in cerebral metabolism and reduced blood flow are decribed, as well as cosmetic methods.
Patent DE-69333960-T2 (DE)
Inventor: SHAHEEN-GOUDA AMAL AHMED
IPC: H04L29/12
Filed: 1993-03-19
Granted: 2006-08-24
Abstract: A unique naming system and method are described for managing object identification by a network of computer systems. The naming system employs data structures stored in the memory of the computer systems containing character strings and corresponding addresses to entries in the data structures and objects in the computer systems. Names employed in a particular computer system that correspond to objects in another computer system are resolved by a border data structure capable of transforming names, delimiters and visas across computer systems.
Patent DE-69403506-T2 (DE)
Inventor: LARSONNEUR LIONEL M
IPC: B65D81/26
Filed: 1994-02-25
Granted: 1997-09-25
Abstract: Absorbent prod. for absorbing liq. bleeding from animal food products comprises, a core including a mat of absorbent material, upper and lower sheet sealed at the periphery to enclose absorbent mat, needling perforations passing through both layers and the core and bundles of fibres extending through the lower layer for wicking transport of liquid therethrough.
Patent DE-69408373-T2 (DE)
Inventor: OHUCHIDA SHUICHI
IPC: A61K31/16
Filed: 1994-05-30
Granted: 1998-07-16
Abstract: The compound of the formula (I) : <CHEM>  wherein R<1> is alkyl substituted by fluorine(s);  R<2> is hydroxy, alkoxy, alkoxy substituted by phenyl, NR<3>R<4>, in which R<3>, R<4> is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R<3> and R<4>, taken together a saturated heterocyclic ring or amino acid residues;  and non-toxic salts thereof and acid addition salts thereof. The compounds of the present invention of the formula (I) and the compounds of the formula (X): <CHEM>  wherein n is 0 or 1,  R<1><1> is hydrogen and chlorine,  R<5> is R<7>-CH2- or R<8>, or  R<5> and R<1><1>, taken together is alkylidene;  R<6> is hydroxy, alkoxy, alkoxy substituted by phenyl, NR<9>R<1><0>, in which R<9>, R<1><0> is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R<9> and R<1><0>, taken together a saturated heterocyclic ring or amino acid residues, R<7> is (i) F-(CH2)m- or F3C-CH2- , (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R<8> is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy; non-toxic salts and acid addition salts thereof are useful for prevention and / or treatment for neurodegenerarive disease (Alzheimer's disease etc.) and neuronal dysfunction by stroke or traumic injury (Multiple sclerosis etc.) etc..
Patent DE-69416860-T2 (DE)
Inventor: SMITH CLIFFORD
IPC: C12Q1/6869
Filed: 1994-12-01
Granted: 1999-07-01
Abstract: PCT No. PCT/GB94/02630 Sec. 371 Date May 24, 1996 Sec. 102(e) Date May 24, 1996 PCT Filed Dec. 1, 1994 PCT Pub. No. WO95/15395 PCT Pub. Date Jun. 8, 1995A method is provided of making a dideoxynucleoside mono-or tri-phosphate, which is optionally 32-P or 33-P or 35-S radiolabelled which involves reacting the corresponding dideoxynucleoside with an optionally radiolabelled nucleotide phosphate or thiophosphate donor in the presence of a kinase of phosphotransferase enzyme which catalyses the reaction. A method of sequencing nucleic acids by a chain termination of a kinase or phosphotransferase enzyme which catalyses the reaction. A method of sequencing nucleic acids by a chain termination technique involves detecting the products of enzymatic synthesis by means of isotopically labelled chain terminating nucleotide analogues.
Patent DE-69427881-T2 (DE)
Inventor: KANGAS WILLIAM W
IPC: E02B3/16
Filed: 1994-01-24
Granted: 2001-11-22
Abstract: A shaped, water-expandable water-sealing article (12) used for sealing an area between a first section (32) of at least partially cured concrete and a second, adjacent section (34) of substantially uncured concrete to form a plurality of water-sealed concrete sections. The clay water sealing article (12) is in the shape of quadrilateral, preferably a trapezoid, and is disposed to bridge an area between the two sections of concrete. Upon hydration of the clay contained within the shaped water sealing article, expansion of the clay creates expansion forces extending from a corner of the article that is surrounded by the uncured concrete, wherein the corner has an included angle greater than 90 DEG , preferably at least 100 DEG . The expansion force developed by the expansion of the shaped water sealing article are absorbed by a substantially increased area of the uncured concrete as compared to expansion forces resulting from a clay-based water seal having a 90 DEG included angle at the corner (s) surrounded by the uncured concrete. <IMAGE>
Patent DE-69430109-T2 (DE)
Inventor: BOMBARDELLI EZIO
IPC: A61K8/00
Filed: 1994-05-18
Granted: 2002-10-02
Abstract: The present invention relates to novel formulations and combinations of lipophilic and hydrophilic antioxidants and the use thereof in the therapeutic, foodstuff, dietetic, and cosmetic fields. These formulations are based on the use of carotenoids, procarotenoids and derivatives thereof with polyphenols of catechic and flavanolignane structures. Said formulations, containing a lipophilic antioxidant and an hydrophilic one at fixed ratios, can be used in the prevention of physiopatological conditions related at least partially to an over-production of free radicals, particularly aging, atherosclerosis and cancer.
Patent DE-69433219-T2 (DE)
Inventor: PRINCE MARTIN R
IPC: G01R33/28
Filed: 1994-06-03
Granted: 2004-08-05
Abstract: This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of a magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate. <IMAGE>
Patent DE-69503120-T2 (DE)
Inventor: MARTIN ULRICH
IPC: A61K38/49
Filed: 1995-03-22
Granted: 1998-11-12
Abstract: The invention involves thrombolytically effective compositions, especially pharmaceutical packaging units for use in treating a patient in need of thrombolytic therapy. Said patient normally undergo thrombolytic therapy by administration of an effective amount of a thrombolytically active protein. The pharmaceutical packaging unit contains a) an effective amount of a non-heparin anticoagulant for use in combination with said thrombolytically active protein and b) an information leaflet providing instructions for use of said non-heparin anticoagulant to allow administration of said anticoagulant in the form of at least one intravenous bolus injection.
Patent DE-69504278-T2 (DE)
Inventor: BUEHRING HANS-JOERG DR
IPC: C07K16/32
Filed: 1995-11-07
Granted: 1999-05-06
Abstract: The present invention identifies a subset of leukemic cells which express HER-2 protein on their cell surface. The invention features methods for inhibiting the growth of such cells and treating leukemia patients by targeting the HER-2 protein. The HER-2 protein is targeted using different techniques such as using anti-HER-2 agents which inhibit HER-2 protein activity and the growth of cells expressing HER-2, using anti-HER-2 agents which bind to HER-2 protein and kill cells expressing HER-2, and using HER-2 protein binding agents to selectively remove leukemic cells expressing HER-2 from normal hematopoietic cells.
Patent DE-69512240-T2 (DE)
Inventor: WEBSTER DAVID
IPC: B23P19/02
Filed: 1995-07-03
Granted: 2000-01-05
Abstract: PCT No. PCT/GB95/01559 Sec. 371 Date Mar. 18, 1997 Sec. 102(e) Date Mar. 18, 1997 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/01167 PCT Pub. Date Jan. 18, 1996Apparatus for inserting elongate members axially into receiving means has elongate member supply means to support and supply the elongate members continuously side-by-side substantially upright in a line. Indexed means serves to supply the receiving means relative to a delivery position and associated delivery means for insertion of the elongate members at least partially into the receiving means. A rotary indexed transfer wheel has spaced edge slots to receive and retain the elongate members in transferring said elongate members between the supply means therefor and said delivery position.
Patent DE-69514581-T2 (DE)
Inventor: PAINTER ROGER BRADY
IPC: C08F2/34
Filed: 1995-07-14
Granted: 2000-08-10
Abstract: The polymerisation of polyolefins in a gas phase reactor having a straight section and an expanded section and in the presence of a transition metal catalyst comprises generating a flow of gas or gas-solids tangentially to one or more interior surface in the expanded section of the reactor to reduce particle build-up.
Patent DE-69532329-T2 (DE)
Inventor: CLARKE NEVILLE
IPC: B01D17/02
Filed: 1995-07-28
Granted: 2004-09-09
Abstract: PCT No. PCT/AU95/00460 Sec. 371 Date Jan. 29, 1997 Sec. 102(e) Date Jan. 29, 1997 PCT Filed Jul. 28, 1995 PCT Pub. No. WO96/04058 PCT Pub. Date Feb. 15, 1996A separation apparatus, particularly for separating two fluids having different densities or specific gravities, is described. The apparatus is provided with a baffle arrangement (22) located within cylindrical housing (3) comprising a plurality of conical-shaped baffles having sloping wall surfaces (24). The conical baffles may be arranged in a nested or stacked relationship or may be connected together to form a continuous helix. A convection current is set up within the apparatus such that one part of the flow is through the baffles in the direction from the base of the conical baffles to the centrally located aperture and the other part of the flow is along the interior walls of the apparatus in a gap between the peripheral edge of the base of the conical baffles and the interior wall. The material to be separated is discharged from the apparatus through a high level outlet acting as an overflow weir.
Patent DE-69610982-T2 (DE)
Inventor: LUNDSTROEM BO
IPC: F16D43/284
Filed: 1996-07-11
Granted: 2001-03-15
Abstract: PCT No. PCT/SE96/00937 Sec. 371 Date Jun. 1, 1998 Sec. 102(e) Date Jun. 1, 1998 PCT Filed Jul. 11, 1996 PCT Pub. No. WO97/04245 PCT Pub. Date Feb. 6, 1997Torque is transmitted between two rotatable, coaxial shaft members in a stationary housing which includes a number of alternate clutch discs connected to the shaft members and engageable to counteract differential rotational speed therebetween, and a hydraulic arrangement driven by the speed differential. The arrangement includes a number of pistons which are axially movable in the housing and are intended to create a hydraulic pressure in the arrangement and thereby to engage the clutch discs, piston actuating devices engaging a shaft member via cams, so as to impart to the pistons a reciprocating movement, and a closed hydraulic system connecting cylinders at all pistons with a hydraulic line containing check-valves. Oil is supplied to the system with a pump and may be removed from the system via an overflow valve.
Patent DE-69612191-T2 (DE)
Inventor: KALLIO KALLE
IPC: C08F4/6192
Filed: 1996-05-02
Granted: 2001-08-02
Abstract: Process for polymerizing or copolymerizing ethylene for manufacturing ethylene polymers or copolymers having a controlled particle size and morphology. Ethylene is polymerized or copolymerized under ethylene polymerizing conditions in the presence of a supported metallocene catalyst, where the average particle size of the catalyst particles is selected within the range of 14-40  mu m and the residence time at the polymerization is selected so as to achieve a polymer where average particle size is between 0.3-0.5 mm and the proportion of fractions between 0.1-0.6 is at least 80 %.
Patent DE-69617888-T2 (DE)
Inventor: VAN OOSTEN CORNELIS WILLEM
IPC: A23L25/00
Filed: 1996-10-18
Granted: 2002-06-20
Abstract: A FLUIDIZED fat composition is described which has an oil blend of 90-99.8 wt. % of an unhydrogenated liquid oil and 10-0.2 wt. % of a fully hydrogenated fat having an iodine value of less than 10 which forms a crystal network in the final composition. The composition optionally contains colors, flavorings, microcrystalline edible salt, essential oils, oleo and aqua resins, natural extractives in conjunction with herb and spices, cheeses and other seasonings, lecithin and antioxidants, starches, sugars, and other flavoring ingredients. It contains low saturated fatty acids and low to substantially no trans fatty acids.
Patent DE-69619974-T2 (DE)
Inventor: WANG JIANJUN
IPC: G10K11/02
Filed: 1996-04-12
Granted: 2002-11-21
Abstract: The need for a highly viscous couplant gel or water spray to form an acoustical couple for ultrasound testing is eliminated by employing an ultrasound probe module. A porous membrane and an ultrasound probe cooperate to define a chamber which contains a liquid acoustical couplant. When pressure is applied to the liquid acoustical couplant it passes through the porous membrane. The porous membrane and chamber are disposed such that ultrasound signals going to or away from the ultrasound probe pass through the liquid acoustical couplant and porous membrane.
Patent DE-69628559-T2 (DE)
Inventor: DOLL J
IPC: A61P35/00
Filed: 1996-04-03
Granted: 2004-04-29
Abstract: Novel carbonyl piperazinyl and piperidinyl compounds of formula (1.0) or (1.1) and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth cells in a mammal such as the human being. A compound of formula (1.0) and (1.1) or a pharmaceutically acceptable salt or solvate thereof, wherein Z is a group which is (i), (ii) or (iii), wherein X1 is CH or N; X2 can be the same or different and can be CH, N, or N-O; b is 0, 1, 2, 3, 4; n and nn independently represent 0, 1, 2, 3, 4 or when X2 is CH, n and nn can be 5; R20 and R21, R1, R2 and R3 are as given in the description.
Patent DE-69631367-T2 (DE)
Inventor: OJANIEMI HEIKKI
IPC: H04B7/26
Filed: 1996-07-25
Granted: 2004-11-04
Abstract: A communication system utilizes an external signal of high accuracy to maintain a good degree of accuracy of synchronization of base sites. A good example of such a signal is the signal transmitted by the global positioning system (GPS) or, a high accuracy PCM (pulse code modulation) or other high accuracy signal provided by a terrestrial transmission network including the base sites. When the synchronization to the GPS signal on one or more base sites cannot be achieved, the communication system employs an alternate synchronization source on those base sites that are missing the synchronization to the GPS signal. The alternate synchronization source is a separate local oscillator of the base site. To achieve the degree of synchronization accuracy provided by the GPS signal, the communication system learns the behavior of each and every local oscillator. This characterization is performed on each base site, and is done by utilizing the GPS signal when the GPS signal is present. When the synchronization to the GPS signal is lost, the characterized local oscillator is then employed such that synchronization of the base sites is transparent to the base sites. Use of the GPS signal to characterize the local oscillators allows the characterized oscillator to provide the same degree of accuracy as that of the GPS signal. The method of characterizing the alternate synchronization source on a site basis makes it possible to take the local oscillators' individual characteristics, as well as the site specific conditions, into account.
Patent DE-69631658-T2 (DE)
Inventor: MOTE L
IPC: G01R31/28
Filed: 1996-06-06
Granted: 2004-12-16
Abstract: Specially modified JTAG test circuitry is used to provide test inputs and outputs for vendor supplied megacells with buried I/Os within an integrated circuit chip. A multiplexer or similar circuit is used to alternatively select between a JTAG boundary scan output or a megacell circuit test output in response to JTAG instructions within an instruction register. Additionally, a multiplexer or similar circuit is used to alternatively select between an input pin or normal circuitry for input to a megacell's buried input. Furthermore, an AND or OR gate is used to allow test inputs to a megacell, which are normally tied either high or low, to be controlled by an input pin when in the special JTAG test mode. In this manner, test vectors applied at test inputs to the megacell circuitry result in test outputs to the megacell circuitry being provided on output pins of the integrated circuit without requiring additional input and/or output pins that are solely operational as test inputs or outputs to the megacell circuitry.
Patent DE-69632854-T2 (DE)
Inventor: OTA MIKIO
IPC: A61K31/426
Filed: 1996-04-04
Granted: 2005-07-14
Abstract: An agent composition for the therapy or prevention of the injury of an organ or a tissue containing a phenylthiazole derivative expressed by the following formula (1) : <CHEM> (R1 is a C1-C8 alkoxy group or a cyclic amino group; R2 is a cyano group or a nitro group; R3 is a hydrogen atom or a C1-C4 alkyl group), and/or its salt as an active ingredient.
Patent DE-69701984-T2 (DE)
Inventor: NIEMOELLER AXEL
IPC: D21H13/24
Filed: 1997-07-01
Granted: 2000-12-07
Abstract: A recording material for the inkjet method with aqueous inks, comprising a substrate paper containing synthetic fibers and comprising a porous recording layer which is arranged on one main surface or both main surfaces of the substrate paper, can be converted into a film and has a basis weight of from 10 g/m<2> to 50 g/m<2>. After conversion of the coating into a film by means of heat, a print on this paper is suitable for outdoor applications and as security paper, owing to its high water resistance and light stability.
Patent DE-69710628-T2 (DE)
Inventor: VAN DER SPOEL JELLE
IPC: C02F3/02
Filed: 1997-04-04
Granted: 2002-11-21
Abstract: The invention relates to a method for purifying protein containing waste water, in which a) a first insoluble material is caused to form in the waste water, b) the mixture obtained in step a) is separated to form pre-purified waste water, c) the pre-purified waste water is treated with aerobic microorganisms and d) the mixture obtained in step c) is separated to form finely purified waste water, and in which step b) and step d) are carried out in the same device. Preferably, steps b) and d) are alternately carried out in the same device. <IMAGE>
Patent DE-69715185-T2 (DE)
Inventor: SAINT-JALMES LAURENT
IPC: C07C211/52
Filed: 1997-04-30
Granted: 2003-04-30
Abstract: The invention features the use of fluorosulphonates to release the organic bases from their fluorohydrate. This use is characterised in that a hydrogenofluorosulphonate of an organic base is formed and in that the hydrofluoric acid which is associated with the said base or with one of its precursors is separated therefrom. The invention is useful in organic synthesis applications.