baber/WOPTO huggingface dataset:
Patent BR-112022024553-A2 (BR)
Title: Composto com atividade inibidora de trpv4 ou um sal farmaceuticamente aceitável do mesmo e seu uso, composição farmacêutica, método para se tratar uma doença da retina acompanhada de distúrbio do fluxo sanguíneo ou distúrbio celular, kit para uso na prevenção ou tratamento das doenças, marcador de doença para uma doença da retina, método para se detectar uma doença da retina, métodos de triagem para uma substância que suprime a expressão do gene de trpv4, uma que reduz o nível de expressão de uma proteína de trpv4 e uma que inibe a atividade de trpv4 e agente para prevenir ou tratar uma doença da retina
Inventor: KENTARO OHARA
IPC: A61P27/02
Filed: 2021-07-16
Abstract: COMPOSTO COM ATIVIDADE INIBIDORA DE TRPV4 OU UM SAL FARMACEUTICAMENTE ACEITÁVEL DO MESMO E SEU USO, COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA SE TRATAR UMA DOENÇA DA RETINA ACOMPANHADA DE DISTÚRBIO DO FLUXO SANGUÍNEO OU DISTÚRBIO CELULAR, KIT PARA USO NA PREVENÇÃO OU TRATAMENTO DAS DOENÇAS, MARCADOR DE DOENÇA PARA UMA DOENÇA DA RETINA, MÉTODO PARA SE DETECTAR UMA DOENÇA DA RETINA, MÉTODOS DE TRIAGEM PARA UMA SUBSTÂNCIA QUE SUPRIME A EXPRESSÃO DO GENE DE TRPV4, UMA QUE REDUZ O NÍVEL DE EXPRESSÃO DE UMA PROTEÍNA DE TRPV4 E UMA QUE INIBE A ATIVIDADE DE TRPV4 E AGENTE PARA PREVENIR OU TRATAR UMA DOENÇA DA RETINA. A presente invenção refere-se a um uso de compostos com atividade inibitória de TRPV4 ou sais farmaceuticamente aceitáveis dos mesmos, ou composições farmacêuticas contendo os mesmos para a fabricação de um medicamento para prevenir ou tratar uma doença da retina acompanhada de distúrbio do fluxo sanguíneo ou distúrbio celular. Também se refere a um método para prevenir ou tratar a doença, em que o método compreende administrar os compostos ou as composições farmacêuticas que os contêm a humanos ou animais. Os compostos, os seus sais farmaceuticamente aceitáveis ou as composições farmacêuticas que os contêm podem ser utilizados em combinação com um ou mais segundos agentes ativos. A presente invenção refere-se a uma composição farmacêutica e um kit contendo um composto com atividade inibitória de TRPV4 ou um sal farmaceuticamente aceitável do mesmo, que é usado para prevenir ou tratar a doença. Além disso, refere-se a um marcador para se diagnosticar uma doença para a qual o tratamento com o composto é útil e um método de triagem para fármacos na prevenção ou tratamento da doença.
Patent BR-112023001636-A2 (BR)
Title: Processo, composição de polímero à base de etileno, e, artigo
Inventor: IVAN A KONSTANTINOV
IPC: C08F210/02
Filed: 2021-07-27
Abstract: PROCESSO, COMPOSIÇÃO DE POLÍMERO À BASE DE ETILENO, E, ARTIGO. A presente revelação fornece um processo. Em uma modalidade, o processo inclui o fornecimento de um agente de ramificação multifuncional (MFBA). O MFBA tem A) três ou mais ligações carbono-carbono duplas com as seguintes condições: (1) o MFBA não é um polímero de butadieno e (2) o MFBA não contém grupos acrilato nem grupos metacrilato. O MFBA tem B) uma reatividade total, R, maior que 3 e menor que 40, (3<R<40) e R é determinado com a seguinte Fórmula (I) na qual: j = índice de somatória, p = o número de diferentes tipos de ligações carbono-carbono duplas j na molécula, nj = o número de cada ligação carbono-carbono dupla do tipo j na molécula, e r1,j = a razão de reatividade relativa (RRR) de etileno para a ligação carbono-carbono dupla j. O processo inclui reagir o MFBA com etileno sob condições de polimerização e formar uma composição de polímero à base de etileno composta por unidades de etileno e unidades do MFBA. A presente revelação fornece também a composição de polímero à base de etileno resultante do processo.
Patent BR-112023006154-A2 (BR)
Title: Cápsulas softgel de liberação modificada
Inventor: KARUNAKAR SUKURU
IPC: A61K9/20
Filed: 2021-10-15
Abstract: CÁPSULAS SOFTGEL DE LIBERAÇÃO MODIFICADA. A presente invenção refere-se a cápsulas softgel de liberação modificada, incluindo uma composição de envoltório dependente do pH, que encapsula uma composição de preenchimento de liberação controlada, métodos de preparação das mesmas e métodos de uso das mesmas. A composição de envoltório dependente do pH pode ser caracterizada pelo fato de que a natureza de liberação retardada das cápsulas pode ser obtida sem um revestimento dependente do pH separado ou polímeros dependentes do pH convencionais adicionados. Os softgéis oferecem uma plataforma de liberação controlada dupla que facilita a distribuição do agente ativo para um local-alvo no trato gastrointestinal e um perfil de liberação controlada do agente ativo no referido local-alvo no trato gastrointestinal.
Patent BR-112023015768-A2 (BR)
Title: Terapia combinada envolvendo anticorpos contra claudina 18.2 para tratamento de câncer
Inventor: KINUGASA FUMITAKA
IPC: A61K33/00
Filed: 2022-03-24
Abstract: terapia combinada envolvendo anticorpos contra claudina 18.2 para tratamento de câncer. a presente invenção fornece uma terapia de combinação para tratar e/ou prevenir doenças associadas a células que expressam cldn18.2, incluindo doenças cancerígenas, como câncer gástrico, câncer de esôfago, câncer de pâncreas, câncer de pulmão, câncer de ovário, câncer de cólon, câncer hepático, câncer de cabeça e pescoço e câncer da vesícula biliar e suas metástases.
Patent BR-122017019820-A2 (BR)
Title: conexões para sistema de umidificação
Inventor: ADRIAN JOHN ELSWORTH
IPC: A61M16/16
Filed: 2014-09-15
Abstract: conexões para sistema de umidificação a presente invenção refere-se a um sistema de umidificação que pode incluir uma base de aquecedor, uma câmara de umidificação e um circuito de respiração. um cartucho pode ser acoplado de modo removível na base do aquecedor. o cartucho pode incluir vários sensores, sondas, conectores de fios do sensor, conectores de fios do aquecedor, e/ou outras funcionalidades. o cartucho pode incluir funcionalidades configuradas para se unirem às funcionalidades correspondentes na câmara de umidificação e na base do aquecedor. o cartucho inclui uma memória, tal como uma eeprom, ou outro dispositivo de armazenamento adequado. quando o cartucho se encontra instalado na base do aquecedor, a memória é conectada eletricamente a um processador e/ou uma memória da base do aquecedor. vários modelos de cartuchos podem ser produzidos para o uso com diferentes câmaras de umidificação, circuitos de respiração, e/ou terapias. um conector pode ser configurado para o acoplamento de um conduíte inspiratório em uma porta de saída da câmara de umidificação. o conector pode fornecer uma conexão pneumática para a porta de saída e uma conexão elétrica para o cartucho.
Patent CZ-194-A3 (CZ)
Title: Process for producing and use of a probiotic preparation containing inorganic substances
Inventor: PROKSAN ZBYNEK ING
IPC: A23K20/28
Filed: 1994-01-03
Abstract: The invention involves the use of a combination of at least one dried anaerobic or facultative anaerobic strain of bacteria of the genera Lactobacterius, Lactococcus and Enterococcus, and bentonite and/or zeolite containing in 1 g 10<1> to 10<10> of vital bacteria, as a probiotic preparation for increasing the use properties of feedstuffs and feed mixtures for farm animals. The above-mentioned combination of bacteria and bentonite and/or zeolite can be used preferably in combination with a protein concentrate with a high content of peptides and essential free amino acids.
Patent SK-8694-A3 (SK)
Inventor: CHROBAK JULIUS
IPC: C02F1/46
Filed: 1994-01-25
Abstract: Biochemické procesy prebiehajúce vo vodnom prostredí
si vyžadujú konkrétne požiadavky na kvalitu vody, jej
chemické zloženie a dodržanie hodnoty pH. Pre optimálny
priebeh biochemických procesov tieto podmienky
najvýhodnejšie zabezpečí použitie vody, ktorá je pri súčasnej
zmene pH na požadovanú hodnotu upravovaná
elelctrodialýzou.
Patent CZ-39596-A3 (CZ)
Title: Conveyance for waste and inspection method of transport channel content
Inventor: MAY KARL
IPC: C10B31/06
Filed: 1994-08-04
Abstract: A conveyor for waste has a waste feed shaft which is laterally connected to a horizontally divided conveyor channel. A screw conveyor being drivable by a motor is located in the longitudinal direction of the conveyor channel. The conveyor channel opens into a housing, in particular into a pyrolysis reactor, which by way of example is operated in conjunction with a low-temperature carbonization combustion process. In order to easily eliminate blockages of the screw conveyor, a unit formed of the screw conveyor and the conveyor channel is disconnectably secured to the housing and is removable from the housing through the use of a traveling mounting. A method for inspecting the contents of a conveyor channel receiving waste and discharging into a housing, especially a pyrolysis reactor, includes disconnecting the conveyor channel from the housing, driving the conveyor channel away with a traveling mounting, and opening the conveyor channel.
Patent CZ-42398-A3 (CZ)
Title: Separating apparatus for voltage discharge gap
Inventor: BACHL HUBERT ING
IPC: H01H79/00
Filed: 1998-02-12
Abstract: A protection circuit arrangement is described for an overvoltage shunt arrangement wired into a supply network that has a first shunt(6) wired between the phase conductors and neutral or plant earth and a second shunt (5) between the neutral and the plant earth. A detection device (2) measures the current through the second shunt and a switch can be triggered by this device. The switch is formed by a contact device (10) which can be operated from a trip device connected to the detection device. It bridges the second shunt and/or it short-circuits the terminals connected to the overcurrent devices (7) of the first shunt against the neutral conductor or plant earth. Thereby the overcurrent protection devices, preferably fuses, blow.
Patent CZ-83597-A3 (CZ)
Title: 4-thia-1-azabicyclo(3,2,0(heptane-3-imino-2-isopropyliden-7-oxo derivatives of beta lactams, process of their preparation and use
Inventor: HERAK JURE J
IPC: C07D513/04
Filed: 1997-03-19
Abstract: The object of the present invention are 4-thia-1-azabicycloÄ3.2.0Üheptane-3-imino-2-isopropylidene-7-oxo beta-lactamic analogons of general formula I <CHEM>  wherein the radicals have the following meanings:     R<1> is hydrogen or halogen,   R<2> is hydrogen, halogen, phtalimide, R<3> is hydrogen, alkyl, benzyl, heterocycle e.g. isoxazole, pyrazole etc.   These compounds are useful as intermediates in the preparation of novel beta-lactamic analogons or of active substances in preparations for antimicrobial therapy.
Patent SK-48499-A3 (SK)
Title: Heteroaryl succinamides and their use as metalloproteinase inhibitors
Inventor: BENDER STEVEN L
IPC: C07D401/04
Filed: 1997-10-06
Abstract: The present invention is directed to compound of formula (I), wherein R1, R2, R3, R4, R5, X, Y and (Ia) are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
Patent SK-50399-A3 (SK)
Title: Absorbent structure with improved absorption properties
Inventor: ANNERGREN JEANETTE
IPC: C08F220/56
Filed: 1997-10-17
Abstract: The invention pertains to an absorbent structure (3) in an absorbent article such as a diaper (100), an incontinence protector, a sanitary napkin or the like, which structure exhibits two end portions (8, 9) and a crotch portion (6) located therebetween, wherein the absorbent structure (3) comprises superabsorbent material having a thermo-reversible liquid absorption capacity. The superabsorbent material having a thermo-reversible liquid absorption capacity is located in one or several delimited regions in the absorbent structure (3).
Patent SK-65793-A3 (SK)
Inventor: DOBIAS JOZEF
IPC: C07D309/38
Filed: 1993-06-24
Abstract: Sukcinimidylester 5-benzyloxy-4H-pyrán-4-ón-2-karboxylovej
kyseliny sa pripraví reakciou 5-benzyloxy-4Hpyrán-4-ón-2-karboxylovej
kyseliny s N-hydroxysukcinimidom
v dioxáne za prítomnosti dicyklohexylkarbodiimidu
pri laboratórnej teplote. Po skončení reakcie a
obvyklom spracovaní sa produkt kryštalizuje z organických
rozpúšťadiel s výhodou z octanu etylového. Zároveň
je opísaný prostriedok na modifikáciu bielkovín a iných
chemických zlúčenín s -NH2 skupinou, ktorý ako účinnú
látku obsahuje vyššie uvedený ester karboxylovej kyseliny
Patent SK-73898-A3 (SK)
Title: Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
Inventor: ZOOK SCOTT E
IPC: C07D401/12
Filed: 1996-12-05
Abstract: The invention relates to compounds of formula (1) wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and N independently is unsubstituted or substituted by a suitable substituent, and at least one of said other ring atoms is a heteroatom selected from O, N and S, and the remainder is carbon atoms; and Ar is an aryl or heteroaryl group; and pharmaceutically acceptable prodrugs, salts and solvates thereof. The invention further relates to pharmaceutically acceptable prodrugs, salts and solvates of these compounds. The invention also relates to methods of inhibiting the activity of metalloproteinases by administering a compound of formula (1) or a produrg, salt or solvate thereof. The invention further relates to pharmaceutical compositions comprising an effective amount of these compounds, prodrugs, salts, and solvates. The invention still further relates to methods and intermediates useful for preparing these compounds prodrugs, salts and solvates.
Patent SK-95298-A3 (SK)
Title: Single or multi row radiator body and process for producing it
Inventor: FONFARA HARALD
IPC: F24H9/12
Filed: 1998-07-10
Abstract: The first section of the radiator, which faces the room to be heated, is uniformly passed by the heating medium before the other sections which can be set behind same. A connection to the at least one other section is preferably only provided at the lower end of the first section. The first section (1) is designed so that at least with a lower heat output more heat is supplied to this first section than to the other sections. The overall length of the flow channels in the first section is greater than in the remaining sections. The first section can be mounted above or below the second section and both sections are preferably formed in one radiator panel.
Patent SK-98494-A3 (SK)
Title: Method of purifying perfluorocarbons, and use of the perfluorocarbons thus purified
Inventor: MEINERT HASSO
IPC: C07C17/395
Filed: 1993-01-21
Abstract: PCT No. PCT/DE93/00061 Sec. 371 Date Nov. 3, 1994 Sec. 102(e) Date Nov. 3, 1994 PCT Filed Jan. 21, 1993 PCT Pub. No. WO93/16974 PCT Pub. Date Sep. 2, 1993Described is a method for the purification of perfluorocarbons, or mixtures of perfluorocarbons, having impurities containing hydrogen and/or carbon-carbon double bonds. The impure perfluorocarbons or perfluorocarbon mixtures are reacted with strong aqueous bases in the presence of Ca2+ or Ba2+ ions and alcoholate ions together with secondary amines.
Patent CH-639812G-A3 (CH)
IPC: G04C17/00
Filed: 1980-04-22
Abstract: A construction of an electronic wrist-watch has a greatly reduced overall thickness constituted by the super-position of the case back 1, at least two time indicating discs 4, 5 and the crystal 8. The remaining elements such as the motor 9, oscillator 14, battery 13 and gear train 10 are placed outside the periphery of the discs. The discs carry respective minute and hour hand marks 6, 7 (the minutes disc 5 being transparent) and are pivoted on a stud 3 on the case back 1. To reduce as far as possible the watch thickness while at the same time maintaining rigidity of the discs, they are supported at their peripheries, which are toothed and driven by the gearing, by rollers 18, 33. <IMAGE>
Patent CH-632382G-A3 (CH)
IPC: G04B33/10
Filed: 1980-04-25
Abstract: In the movement for an electronic watch with analogue display, hand-carrying arbors 20, 22 have pinions 20a, 22a of very small diameter, rather than wheels. The cell 10 has a diameter which is substantially equal to the radius of the movement plate 2, since the cell extends from the periphery of the movement up to the pinions 20a, 22a. The wheels 28, 30, 34, 40, 42 which drivably connect the motor 8 to the pinions 20a, 22a are arranged in such a manner that there is no overlapping between the cell 10 and the wheels. This makes possible a movement which is both of small diameter and thin.
Patent CS-137492-A3 (CS)
Title: Ultrafiltration processes of polymer latexes regeneration from verydiluted aqueous latex emulsion and apparats for making the same
Inventor: BUCKLEY RANDALL GEORGE
IPC: C08F6/20
Filed: 1992-05-06
Abstract: Polymer is recovered by ultrafiltration from a whitewater waste stream generated during the production of a polymer latex. The whitewater stream is circulated through an ultrafiltration system in laminar flow, under conditions of shear insufficient to destabilize the whitewater emulsion, and the recovered polymer is in the form of an emulsion which may be blended at significant levels into the original polymer latex without degrading its performance properties. <IMAGE>
Patent CZ-224192-A3 (CZ)
Title: wall, ceiling or beam structural element and a wall made therefrom
Inventor: ASCHENBRENNER FRANZ
IPC: E04C2/12
Filed: 1992-07-17
Abstract: The tongue and groove joint joining two members of a compound wood member are dimensioned to match the size of the components making up the compound member. Thus during the shaping of the member,  work after joint formation is reduced. The individual planks (13-19) are all of the same thickness. They are placed on edge and glued together to form wall elements. Most of the planks are the same width with squared-off edges. The central planks (16) are displaced upwards, to make tongue-and-groove joints. the facing planks (13) may be cut-away to make visible joints. USE/ADVANTAGE - Joint construction in wooden building is cheap and simple and reduces timber waste.
Patent CZ-262393-A3 (CZ)
Title: Process and apparatus for dissolving and activation of a soluble cleansing agent
Inventor: MARKLAND THOMAS ARTHUR
IPC: D06F39/02
Filed: 1992-06-01
Abstract: A method and apparatus is provided for dissolving or dispersing a predetermined quantity of granular cleansing agent into a cleansing liquor and delivering the cleansing liquor to a cleansing application, such as a clothes washing machine. A predetermined quantity of granular cleansing agent (74) is placed in an inner container (54) upon a screen (58). Water from the container is withdrawn and recirculated such that upon reentry to the container it is directed at the screen (58) and diffused to dissolve and disperse the granular cleansing agent (74) forming a solution and diffused to prevent the undissolved but wetted cleansing agent from adhering to the inner container (54). Preferably, the diffused solution operates to substantially immediately float an island of the undissolved granular cleansing agent in the center of the inner container. Also, the cleansing liquor is preferably not delivered to the cleansing application until after substantially all of the various components within the granular cleansing agent have transformed by appropriate reaction into their "active" state.
Patent CZ-101098-A3 (CZ)
Title: Process of spreading a single type of fertilizer or simultaneous spreading of several kinds of fertilizer by making use of centrifugal spreader
Inventor: DREYER HEINZ DR DIPL ING
IPC: A01C17/00
Filed: 1998-04-03
Abstract: The fertiliser spreader has at least two storage containers for at least two different types of fertiliser. Each storage container has at least two dispenser (23) and distributor elements. The dispenser elements are in the form of outlets closed and adjusted by slide pieces (25) with adjustable elements (26) for the width of aperture of the outlets. The distributor elements are in the form of casting-discs (18) with throw-shovels (19) adjustable at various angles to the horizontal. Conveyor elements (28) carry the material onto the bottom casting discs below the top casting discs inside the circulating paths described by the outermost parts of the casting discs. The bottom hopper ends (16) are on the same level as the storage containers (1,2).
Patent CZ-111593-A3 (CZ)
Title: Method of pouring and formation of arranged layer of catalyst particles or/and sorptive materials and apparatus for making the same
Inventor: LEDERER JAROMIR ING CSC
IPC: B01J4/00
Filed: 1993-06-09
Abstract: A method of pouring and formation of arranged layer of catalyst particles or/and sorption materials with high density for heterogeneous chemical or physico-chemical processes, during which the flow of falling particles come into contact with a flow of inert gas, which flows tangentially in the direction plumb to the fall of particles in a mass ratio of gas and falling particles of 10 to 10,000, whereas the gas flows uniformly under pressure in a range of 50 to 250 kPa. The equipment for carrying out the described method includes a chute equipped on the bottom with a hole with diaphragm (1) and cyclone chamber (2) equipped with two nozzles (3), whereas the cyclone chamber is provided with a pressure chamber (4), located in which are the input holes of the nozzles and inside the cyclone chamber there is a concentric building-in (7), equipped with arched ribs (8).<IMAGE>
Patent CZ-156599-A3 (CZ)
Title: Solid polyurethane foams
Inventor: SIEKER THOMAS HEINRICH
IPC: C08G18/20
Filed: 1997-10-10
Abstract: Process for making rigid polyurethane or urethane-modified polyisocyanurate foams comprising the step of reacting an organic polyisocyanate composition with an isocyanate-reactive composition comprising a polyester polyol in the presence of an amine catalyst characterized in that the pKa of the conjugated ammonium salt of said amine is less than 12.
Patent CZ-171496-A3 (CZ)
Title: Composition of sodium-lime glass and the use thereof
Inventor: KOCH STEPHANIE
IPC: C03C3/087
Filed: 1995-10-13
Abstract: Glass composition consists of in wt.%: 45-68 SiO2; 0-20 Al2O3; 0-20 ZrO2; 0-10 B2O3; 2-12 Na2O; 3.5-9 K2O; 1-13 CaO; 0-8 MgO. The sum of SiO2, Al2O3 and ZrO2 is max. 70% and the sum of Al2O3 and ZrO2 is at least 8%. The glass may also contain BaO and/or SrO such that MgO+CaO+BaO+SrO is 11-30%. The glass has a strain point of at least 530 degrees C and an expansion coefficient of 80-90 x 10<-7>/ degrees C.
Patent CZ-175098-A3 (CZ)
Title: Enhanced catalysis process by making use of metal-ligand complex
Inventor: BRYANT DAVID ROBERT
IPC: C07F9/02
Filed: 1996-12-05
Abstract: THIS INVENTION RELATES TO A PROCESS WHICH COMPRISES REACTING ONE OR MORE REACTANTS IN THE PRESENCE OF A METAL-ORGANOPOLYPHOSPHITE LIGAND COMPLEX CATALYST TO PRODUCE A REACTION PRODUCT FLUID COMPRISING ONE OR MORE PRODUCTS, WHEREIN SAID PROCESS IS CONDUCTED AT A FREE ORGANOPOLYPHOSPHITE LIGAND CONCENTRATION SUFFICIENT TO PREVENT AND/OR LESSEN HYDROLYTIC DEGRADATION OF THE ORGANOPOLYPHOSPHITE LIGAND AND DEACTIVATION OF THE METAL-ORGANOPOLYPHOSPHITE LIGAND COMPLEX CATALYST.
Patent CZ-185897-A3 (CZ)
Title: Dna purification method by formation of treble helix with immobilized oligonucleotide
Inventor: CROUZET JOEL
IPC: C12Q1/68
Filed: 1995-11-08
Abstract: A novel method for purifying double stranded (ds) DNA comprises passing a mixt. contg. the DNA in soln. over a support to which an oligonucleotide (ON) is covalently attached, where the ON is able to form a triple helix by hybridisation with a specific sequence (I) present in the DNA.