baber/WOPTO huggingface dataset:
Patent AU-2020254929-A1 (AU)
Title: Antisense oligonucleotides for immunotherapy
Inventor: YILMAZ-ELIS ALIYE SEDA
IPC: A61P31/00
Filed: 2020-03-27
Abstract: The invention relates to antisense oligonucleotides (AON) capable of inducing the skip of at least exon 3 from (human) CD274 pre-mRNA to render a shortened PD-L1 protein, and thereby modulating the function of PD-L1. Preferably, PD-L1 that is produced after the skip of exon 3 from its pre-mRNA is no longer able to traffic to the cell membrane and/or is no longer able to (fully) interact with its receptor PD-1. The result is preferably that the PD-1/PD-L1 pathway is blocked and T cell exhaustion is diminished, prevented or lowered. The AONs of the present invention are particularly useful in immunotherapy and can be applied in the treatment, prevention, and amelioration of (acute or chronic) viral infections, cancer and (auto-) immune disease, especially those disorders in which T cell exhaustion plays a role. The invention relates to AONs, pharmaceutical compositions comprising such AONs, and viral vectors expressing such AONs, that may be used in the treatment of subjects that may benefit from modulation of PD-L1 function.
Patent AU-2020267858-A1 (AU)
Title: Novel polysaccharide-based hydrogel scaffolds for wound care
Inventor: ZHANG CHI
IPC: A61L26/00
Filed: 2020-05-07
Abstract: The present invention relates to a hydrogel comprising polysaccharide polymer network and collagen, particularly for use in the wound treatment. The present invention also relates to a wound dressing and a cell culture system comprising the hydrogel and their use in the wound treatment.
Patent AU-2020309773-A1 (AU)
Title: Multi-junction photovoltaic device
Inventor: SEBASTIEN THOMAS
IPC: H01L31/072
Filed: 2020-07-10
Abstract: A multi-junction photovoltaic device comprises a first sub-cell (11b) and a second sub-cell (11a), the second sub-cell (11a) overlying the first sub-cell (11b) such that incident light passes through the second sub-cell (11a) before the first sub-cell (11b). The light-receiving surface of the second sub-cell (11a) comprises a layer of a transparent conductive material (12) and one or more metal tracks (13) extending in a first direction and in contact with the layer of transparent conductive material (12). A layer of electrically insulating material (16) is provided on the light receiving surface of the second sub-cell (11a) located under one end of the one or more metal tracks (13) at an edge of the device, and an electrically conductive pad (14) is provided over the layer of electrical insulator (16) and in electrical contact with the one or more metal tracks (13) to provide electrical contact to an external circuit.
Patent AU-2020310108-A1 (AU)
Title: Intelligent load balancer
Inventor: MOHANTY AMITAV
IPC: G06F9/50
Filed: 2020-07-02
Abstract: Techniques for routing requests on a network are described. In accordance with certain aspects, a temporal window is incremented or moved over time to facilitate dynamic routing decisions. The temporal window may be used to project or estimate incoming request traffic based on a suitable probabilistic distribution model, such as a Poisson or Gaussian probability distribution, applied to the window so as to estimate or predict traffic at different times as the window is incremented. Estimated execution times for incoming requests may also be computed so that arrival and completion times of each request or traffic event can be modeled. Processor-implemented routines may be employed to solve the sub-problems defined by the temporal window incoming traffic estimation and the estimated execution times efficiently, allowing the parent or overall routing decision problem to be solved efficiently using dynamic processes, including in real-time contexts.
Patent AU-2020320207-A1 (AU)
Title: Compositions and methods of using multipotent stem cells to reduce disease and enhance wellness
Inventor: WADE JILL
IPC: A61C8/00
Filed: 2020-07-29
Abstract: Provided herein are methods of using multipotent stem cells in treatment or prophylaxis of disease, in a system for improving general health and overall wellness. The disclosure provides a method in which multipotent stem cells are intravenously administered within the oral cavity, which has a rapid effect on symptoms of inflammation and/or infection, not only treating periodontal diseases, but also reducing bacterial load, pain, bone loss, etc. as well as stimulating new bone growth and achieving other hallmarks of improvement in health and overall systemic wellness. In some instances, a sample of a bodily fluid is drawn from the patient before injection to measure baseline levels of several biomarkers to obtain the patient's status on the spectrum of health and wellness and/or to compare post-treatment effects of the injected stem cells, to measure improvement, and to develop a treatment plan for enhancing multisystem wellness.
Patent AU-2020323657-A1 (AU)
Title: Fault isolation apparatus, direct current boost apparatus, and inverter apparatus
Inventor: ZHANG FANGPO
IPC: H02J3/38
Filed: 2020-06-10
Abstract: Disclosed are a fault isolation apparatus, a direct current boosting apparatus and an inversion apparatus, which belong to the technical field of power sources. The fault isolation apparatus comprises a controller and a circuit breaker. When the circuit breaker is located on a bus connected to a certain DC/DC conversion unit, if the voltage collected by a first voltage collection end is a negative value, this indicates that input or output of the DC/DC conversion unit is reversely connected, and at this time, the circuit breaker is controlled to be disconnected, so that the DC/DC conversion unit can be prevented from being connected in series to other DC/DC conversion units connected in parallel. If the voltage collected by the first voltage collection end is relatively low and the current collected by a current collection end is relatively large, this indicates that the DC/DC conversion unit is short-circuited itself, and at the time, the circuit breaker is controlled to be disconnected, so that the situation in which other assemblies connected to the DC/DC conversion unit in series flow back energy to the DC/DC conversion unit can also be prevented.
Patent AU-2020325291-A1 (AU)
Title: Technologies for content presentation
Inventor: BATKIN ANDY
IPC: G06Q30/00
Filed: 2020-08-06
Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.
Patent AU-2020329081-A1 (AU)
Title: A sensor assembly and monitoring system for an idler roller in a belt conveyor system
Inventor: BULL DAVID JOHN
IPC: B65G39/09
Filed: 2020-08-12
Abstract: A sensor assembly (115) has a housing (320) for mounting on a shaft (110) of an idler roller (10) in a belt conveyor system. The housing (320) has one or more sensors (140, 150, 310, 360, 270, 390) for detecting one or more parameters of the idler roller (10) and a processor (230) in communication with the sensors and a wireless communication device (240, 250). The sensors transmit the detected parameter data (460) to the processor, which causes the detected parameter data to be transmitted by the wireless communication device. A monitoring system is also provided.
Patent AU-2020340547-A1 (AU)
Title: Soft tissue reconstruction implants and forming method therefor
Inventor: CHHAYA MOHIT PRASHANT
IPC: A61L27/18
Filed: 2020-09-04
Abstract: Embodiments herein relate to implants for insertion into a patient suitable for soft tissue reconstruction. The implant (200) comprises a plurality of unit cells (102) arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure (101), wherein the three-dimensional structure is a reversibly compressible three- dimensional structure, and wherein the bulk porosity of the three- dimensional structure of the implant is at least 50 %.
Patent AU-2020342108-A1 (AU)
Title: Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof
Inventor: DUAN WENHU
IPC: C07F7/08
Filed: 2020-09-03
Abstract: A compound having Axl and c-Met kinase inhibitory activity, a preparation method therefor and an application thereof. Specifically, a compound having the structure represented by formula (I), a preparation method therefor and an application thereof in the preparation of a medication for the treatment and/or prevention of tumor-associated diseases and/or kinase-related diseases.
Patent AU-2020347958-A1 (AU)
Title: System and method for supplying return activated sludge
Inventor: LAWRENCE DARREN PAUL
IPC: C02F3/30
Filed: 2020-09-18
Abstract: A method of processing waste water to produce a filtrate is provided. The method includes the steps of: introducing untreated wastewater (200) to an inlet zone (202b) of a bioreactor (303); introducing a concentrate of treated wastewater (206) with at least 10,000 mg/L of total suspended solids into the inlet zone of the bioreactor to form a biological active mixture; aerating the biological active mixture in an aeration zone (203) of the bioreactor to produce treated waste water; filtering the treated wastewater to produce a filtrate (205) and the concentrate (206), wherein the filtrate (205) created by the filtering has total suspended solids of less than 10 mg/L; transferring at least a portion of the concentrate (206) to the inlet zone (202b) of the bioreactor; and transferring the filtrate external to the bioreactor as clean water.
Patent AU-2020392407-A1 (AU)
Title: Surgical system
Inventor: URVOY FRANÇOIS
IPC: A61B17/16
Filed: 2020-11-26
Abstract: The present disclosure relates to a surgical system for treating an anatomical structure according to a plurality of target planes and/or axes, comprising: - a robotic device (1) comprising: - an end effector (2) defining a current plane or axis, - an actuation unit (11) coupled to the end effector (2), - a tracking unit (3) configured to determine a pose of the current plane or axis, - a control unit coupled to the tracking unit and configured to control the actuation unit (11) to align the current plane or axis of the end effector (2) with each one of the plurality of target planes and/or axes to treat the anatomical structure, the robotic device being operable in at least the following modes: - a working mode wherein a treatment is being performed with the end effector constrained to one target plane or axis by the actuation unit, and - a waiting mode wherein no treatment is being performed and the actuation unit is operable to move the end effector in alignment with another target plane or axis, wherein the control unit is further configured to: (a) determine that the robotic device (1) is in the waiting mode; (b) detect a triggering force applied to the end effector (2) and/or the actuation unit (11) in at least one first direction; (c) as a result of determination (a) and detection (b), trigger a position change of the end effector (2) by the actuation unit (11) to align the current plane or axis with a next target plane or axis.
Patent AU-2020403242-A1 (AU)
Title: Classification models for analyzing a sample
Inventor: ZAIT AMIR
IPC: G06K9/00
Filed: 2020-12-10
Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.
Patent AU-2020403566-A1 (AU)
Title: Child-resistant package
Inventor: BRUUN HANNA
IPC: B65D5/38
Filed: 2020-12-11
Abstract: The present invention relates to a child-resistant package and to a package blank,such as a carton blank, useful for construction of a child-resistant package. The package comprises an outer casing and an inner casing arranged slidably within the outer casing and being movable between a closed position and an open position wherein immediate opening of the package from the closed position to the open position is prevented.
Patent WO-2022040753-A1 (WO)
Inventor: SINGLE PETER SCOTT VALLACK
IPC: A61N1/36
Filed: 2021-08-27
Abstract: A method of controlling a neural stimulus, the neural stimulus being defined by at least one stimulus intensity parameter. The method comprises generating a stimulus intensity parameter to control a stimulator that generates a stimulus current for application to a tissue, measuring a response of the tissue, evoked by the stimulus current, determining a forward adjustment parameter as a function of the stimulus intensity parameter, determining a feedback parameter derived from the measured response and the forward adjustment parameter and adjusting the stimulus intensity parameter according to the feedback parameter.
Patent AU-2021200612-A1 (AU)
Title: Common search space for machine type communications
Inventor: ALVARINO ALBERTO RICO
IPC: H04W4/90
Filed: 2021-01-29
Abstract: OF THE DISCLOSURE 
Certain aspects of the present disclosure generally relate to wireless 
communications and more specifically to search space configuration in systems utilizing 
devices with limited communications resources, such as machine type communication 
(MTC) devices and enhanced MTC (eMTC) devices. An example method generally 
includes receiving a physical random access channel (PRACH) signal from a first user 
equipment (UE) on a first narrowband region within a wider system bandwidth and 
transmitting, in response to the PRACH signal, a random access response (RAR) signal in 
a first search space in a second narrowband region in at least a first subframe.
Patent AU-2021202194-A1 (AU)
Title: Omega-hydroxylase-related fusion polypeptides with improved properties
Inventor: ZHU BAOLONG
IPC: C12P7/64
Filed: 2021-04-12
Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in 
improved omega-hydroxylated fatty acid derivative production when expressed in recombinant 
host cells. The disclosure further relates to microorganisms for expressing the omega
hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid 
derivatives.
Patent AU-2021212141-A1 (AU)
Title: Bacteria engineered to reduce hyperphenylalaninemia
Inventor: FALB DEAN
IPC: C12N9/88
Filed: 2021-08-06
Abstract: BACTERIA ENGINEERED TO REDUCE HYPERPHENYLALANINEMIA 
Abstract 
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of 
modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
Patent AU-2021250927-A1 (AU)
Title: Virtual item control method and apparatus, terminal, and storage medium
Inventor: WU SHENGYU
IPC: G06F3/048
Filed: 2021-08-24
Abstract: Embodiments of this application disclose a virtual item control method and apparatus, a 
terminal, and a storage medium, and belong to the field of computer technologies. The method 
includes: displaying a plurality of item icons after a press operation on a throw button is detected; 
controlling, when the press operation moves to the target item icon and a duration reaches a target 
duration, a virtual object to hold a target virtual item corresponding to the target item icon; 
controlling, in response to a movement of the press operation, the virtual object to aim at a target 
position; and controlling, in response to a release of the press operation, the virtual object to throw 
the target virtual item to the target position. The display, selection, aiming, and throwing of the 
virtual item can be completed only when a user is required to perform one continuous and coherent 
press operation, thereby simplifying the operation procedure and improving the throwing efficiency.  
51
Patent AU-2021254585-A1 (AU)
Title: Displaying options, assigning notification, ignoring messages, and simultaneous user interface displays in a messaging application
Inventor: YANG LAWRENCE Y
IPC: H04L12/58
Filed: 2021-10-20
Abstract: OF THE DISCLOSURE 
An electronic device with a touch-sensitive surface and display can execute a messaging 
application. In the messaging application, swipe options can be displayed for messages and 
threads. Swipe options correspond to actions that can be taken on the messages or threads.  
Messages and threads can be associated with notification rules as well as be ignored.  
Composition interfaces and messages can be displayed simultaneously in the messaging 
application. The messaging application can display a conversation view of a message thread 
with a common header that can include subject information and names of participants in the 
threads. The messaging application allows for adding and removing participants to the 
conversation view. The messaging application allows for grouping search results from a 
search of messages using a search term. The grouping can be based on the location of the 
search term within the messages.
Patent AU-2021268753-A1 (AU)
Title: Bioinformatics
Inventor: CERULLO VINCENZO
IPC: G01N33/543
Filed: 2021-05-06
Abstract: The invention concerns a device for tumour antigen identification and a method for tumour antigen identification; a tumour antigen identified following use of said device and/or method; a pharmaceutical composition comprising said tumour antigen; a method of treating cancer using said device and/or said method; a method of stratifying patients for cancer treatment using said device and/or said method; a treatment regimen involving stratifying patients for cancer treatment using said device and/or method and then administering a cancer therapeutic; and a tumour antigen identified using said device and/or said method for use as a cancer vaccine or immunogenic agent or cancer therapy.
Patent AU-2021290387-A1 (AU)
Title: Labeled nucleotide compositions and methods for nucleic acid sequencing
Inventor: ROTHBERG JONATHAN
IPC: C12N15/11
Filed: 2021-12-24
Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities 
are provided. In some aspects, methods of sequencing nucleic acids involve determining the 
luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently 
labeled nucleotides incorporated during a nucleic acid sequencing reaction. In some aspects, 
the disclosure provides compositions comprising luminescently labeled nucleotides.
Patent AU-2021292240-A1 (AU)
Title: Coffee machine and method for dispensing a milk emulsion with said coffee machine
Inventor: PANCIERA ANTONIO
IPC: A47J31/44
Filed: 2021-05-07
Abstract: The coffee machine (1) comprises a water tank (23), boiler (2) for the production of steam, a water supply pump (3) for supplying water to the boiler (2) for generation of steam, an external coffee dispenser (4), an external steam dispenser (5) having a dispensing opening (21) for dispensing a steam flow, a milk container (6) having an emulsifying device for emulsifying the milk by Venturi effect generated by the steam flow, the emulsifying device (7) having a mixing chamber (10) for mixing milk/steam/air, a milk aspirating channel (12) by Venturi effect having an inlet opening (11) into the mixing chamber (10), an air aspirating channel (14) by Venturi effect having valve means (15) and an inlet opening (13) into the mixing chamber (10), the mixing chamber (10) having a sealed removable connection opening (16) with the external steam dispenser (5) and an outlet opening (17) of the milk emulsion aligned to the steam dispensing opening (21) and connected to an external dispenser (9) of the milk emulsion, wherein the outlet opening (17) of the milk emulsion is larger than the steam dispensing opening (21) for the activation of the Venturi effect, the milk aspirating channel (12) is dimensioned with a minimal passage area sufficiently large to provide an efficiency of milk aspiration by Venturi effect to which the dispensing of a milk emulsion, at a temperature no more than 25°C higher than the temperature of the milk present in the milk container (6) corresponds.
Patent AU-2021328048-A1 (AU)
Title: Enhanced wireless power transfer
Inventor: NALBANT MEHMET K
IPC: H02J50/10
Filed: 2021-07-23
Abstract: Wireless power transfer devices may be configured to negotiate with each other to operate. For example, a wireless power standard may provide for various levels of power delivery, various frequencies for power transfer, various operating voltages, and so forth. There may be instances in which it is desirable to provide wireless power transfer devices (both PTx and PRx) that are capable of enhanced performance when paired with a compatible device. For example, devices can be configured to operate at higher or more granular power levels, different frequencies, and so forth.
Patent AU-2021330374-A1 (AU)
Title: Heaters for medical devices
Inventor: LAMBLE RALPH
IPC: B01L7/00
Filed: 2021-08-26
Abstract: A medical device comprising a multilayer printed circuit board (PCB) comprising a heating element on an inner layer of the PCB; a single cell electrical power source to power the heating element; and a chamber adapted to contain a liquid, at least part of said chamber being defined by a thermally conductive material configured to provide a thermal transfer interface between the chamber and the PCB.
Patent AU-2021334400-A1 (AU)
Title: Biomarker topology quantification and assessment for multiple tissue types
Inventor: LEE GEORGE
IPC: G06F18/213
Filed: 2021-08-31
Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using artificial intelligence and machine learning. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. A machine learning algorithm is then trained using results of the image analysis and the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the training, a machine learning feature space comprising a plurality of classifications is generated, and boundaries between the plurality of classifications in the machine learning feature space are identified.
Patent AU-2021378316-A1 (AU)
Title: Combination therapies with chimeric antigen receptor (car)-expressing cells
Inventor: CHADBOURNE ANA
IPC: A61K39/00
Filed: 2021-11-12
Abstract: This disclosure provides methods for treating a B-cell lymphoma, by administering a CD 19 CAR therapy as described herein, in combination with a BCL2 inhibitor as described herein.