baber/WOPTO huggingface dataset:
Patent SG-169918-A1 (SG)
Title: Microfluidic devices with removable cover and methods of fabrication and application
Inventor: COHEN DAVID
Filed: 2009-10-02
Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader. Fig. 1B
Patent SG-165291-A1 (SG)
Title: Substrate for a magnetic disk and method of manufacturing the same
Inventor: TSUCHIYA HIROSHI
IPC: B24B37/08
Filed: 2010-03-30
Abstract: In a magnetic disk substrate having first and second chamfered faces respectively connecting between first and second main surfaces opposite to each other and an edge face located between the first and second main surfaces, the ranges of the first and second chamfered faces are specified. Specifically, the distance a from a first boundary portion being a boundary between the first main surface and the first chamfered face to a point of intersection between the first main surface and an extended line of the edge face and the distance b from a second boundary portion being a boundary between the second main surface and the second chamfered face to a point of intersection between the second main surface and an extended line of the edge face are set to satisfy a/b>1.6.
Patent SG-165414-A1 (SG)
Title: Glp-1 ( glucagon-like peptide-1 ) fusion polypeptides with increased peptidase resistance
Inventor: GEIGLE PETER
Filed: 2006-09-22
Abstract: The present invention provides fusion peptides having GLP-1 activity and enhanced stability in vivo, in particular resistancy to dipeptidyl peptidase IV. The fusion peptide comprises as component (I) N-terminally a GLP-1 (7-35, 7-36 or 7-37) sequence and as component (II) C-terminally a peptide sequence of at least 9 amino acids or a functional fragment, variant or derivative thereof. Component (II) is preferably a full or partial version of IP2 (intervening peptide 2). A preferred embodiment comprises the sequence GLP-1 (7-35, 36 or 37)/IP2/GLP-1(7-35, 36 or 37) or GLP-2. The fusion peptide may be produced in engineered cells or synthetically and may be used for the preparation of a medicament for treating various diseases or disorders, e.g. diabetes type I or 2, apoptosis related diseases or neurodegenerative disorders. -NO FIGURE-
Patent SG-171899-A1 (SG)
Title: Method for pretreating specimen and method for assaying biological substance
Inventor: TAJIMA HIDEJI
Filed: 2009-12-25
Abstract: On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are' mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet comes close to the pipette chip. While remotely constraining with the magnet the magnetic particles carrying the nonspecific reaction factor bonded thereto, the residual liquid is discharged into a well. Thus, the removal of a contaminant contained in the specimen is completed. The thus treated specimen discharged into the well is subjected to an immunoassay. The magnetic particles carrying the antibody immobilized thereon are mixed with the treated specimen and suspended therein. The suspension is sucked up into a pipette chip and the magnetic particles carrying an antigen bonded thereto are separated by use of the magnet. The magnetic particles carrying the antigen bonded thereto are washed, mixed with an enzyme-labeling solution, which contains a second support, and suspended therein. After suspending, the magnetic particles being labeled and carrying the antigen bonded thereto are mixed with a substrate solution and subjected to the measurement of emission intensity, etc.
Patent SG-172729-A1 (SG)
Title: A method of selecting an arrangement of sectors for a turbomachine nozzle
Inventor: MENUEY JUSTINE
Filed: 2008-12-19
Abstract: 5A method of selecting an arrangement of sectors (100, 200, 300) for a turbomachine nozzle, the method comprising the following steps:creating a database of three-dimensional 10 numerical models of the sectors by digitizing;setting a criterion for selecting an arrangement of sectors and setting a desired value for said criterion, the criterion being a function of the shapes and the relative positions of the sectors;15 C) for the various arrangements that are evaluated,determining the relative positions of the sectors when assembled together by performing a virtual assembly, and as a function of said positions, determining the value of the selection criterion for the arrangement under20 evaluation; andD) retaining the arrangement for which the selectioncriterion has the value closest to the desired value.This method serves to optimize selecting sectors in a nozzle.25Fig. 1
Patent SG-175436-A1 (SG)
Title: Antibodies against nerve growth factor (ngf) with enhanced in vivo stability
Inventor: POWELL JOHN
Filed: 2010-05-04
Abstract: The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Patent SG-177761-A1 (SG)
Title: Biodegradable polyethylene glycol based water-insoluble hydrogels
Inventor: RAU HARALD
Filed: 2010-07-30
Abstract: The present invention relates to biodegradable polyethylene glycol based water-insoluble hydrogels comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the backbone moieties further comprising reactive functional groups, wherein the water-insoluble hydrogel is further characterized in that the ratio between the time period for the complete degradation of the hydrogel by hydrolysis of the degradable bonds into water-soluble degradation products comprising one or more backbone moieties and the time period for the release of the first 10 mol-% of water-soluble degradation products comprising one or more backbone moieties based on the total amount of backbone moieties in the hydrogel is greater than 1 and equal to or less than 2. The invention further relates to conjugates of such hydrogels with ligands or ligating groups, prodrugs and pharmaceutical compositions as well as their use in a medicament.
Patent SG-183136-A1 (SG)
Title: Process of producing arginine employing corynebacterium glutamicum atcc 21831 or corynebacterium glutamicum atcc 21493 in a afermantation medium comprising cassava bagasse or jackfruit seed as a carbon source
Inventor: PANDEY ASHOK
Filed: 2010-02-25
Abstract: Disclosed are processes for producing Arginine by fermentation in which sugars obtained by enzymatic starch hydrolysis from inexpensive starch containing agro-wastes, such as Cassava bagasse and Jackfruit seed powder, are fermented in the presence of microorganisms to produce a fermentated liquor containing Arginine, and recovering Arginine from the liquor. The process can economically be scaled up for the production of Arginine from unrefined sugar sources as it produced Arginine in higher yields, when compared to more expensive synthetic carbon sources, like dextrose or sucrose.
Patent SG-184457-A1 (SG)
Title: Bottle packaging for flowable product
Inventor: MAZER TERRENCE B
Filed: 2011-04-04
Abstract: A bottle packaging includes a groove on the neck of a bottle with the groove spaced longitudinally from a shoulder of the bottle a distance greater than or equal to a width of the groove, and upper and lower portions of the neck may have outer transverse cross-sectional dimensions that are substantially equal to one another. An upper circumferential sidewall of the groove may be chamfered, while a lower circumferential sidewall may be concave. The bottle may be combined with an adapter such that when the adapter is releasably connected to the bottle, a lowermost rim of the adapter is spaced longitudinally from an upper reach of the groove. The adapter may include a detent on an inner surface thereof adapted to removably seat in the groove to releasably connect the adapter to the bottle. A closure member may include at least one of a detent and a sealing member removably seated in the groove.
Patent WO-2013130016-A1 (WO)
Title: Modification de floraison de jatropha et d'autres plantes
Inventor: CHUA NAM-HAI
IPC: C12N15/82
Filed: 2013-02-27
Abstract: L'invention concerne le domaine de la modification de la ramification, du temps de floraison, de la production de fruits et de la grenaison de  Jatropha . L'invention concerne plus spécifiquement un procédé de régulation et d'optimisation du temps de floraison, de la production de fruits et de la production de graines de  Jatropha curcas  par manipulation d'un gène provenant de  Jatropha . L'invention peut être utilisée dans des tentatives variées pour cultiver  Jatropha .
Patent WO-2014014422-A1 (WO)
Title: Combinatoric encoding methods for microarrays
Inventor: TRAU DIETER
IPC: C12Q1/68
Filed: 2013-07-19
Abstract: The present invention relates to a method of encoding and decoding of a microarray which is used for detecting the presence of one or more target analytes in a sample. Further disclosed are microarrays produced according to these methods and their use.
Patent WO-2014017986-A1 (WO)
Title: Dispositif d'accès vasculaire et partie de guidage
Inventor: PEH RUEY FENG
IPC: A61M5/158
Filed: 2013-07-26
Abstract: Divers modes de réalisation de l'invention concernent un procédé et un système pour obtenir un accès à un vaisseau sanguin au-dessous d'une couche de peau, lesquels procédé et système peuvent préserver la durée de vie du vaisseau sanguin et réduire la variabilité de compétences d'exécution. Le procédé comprend le positionnement d'une partie de guidage entre le vaisseau sanguin et la couche de peau ; et la configuration de la partie de guidage pour recevoir et guider une aiguille pour atteindre à plusieurs reprises et systématiquement le même emplacement du vaisseau sanguin ; et la formation d'une voie marquée résultante entre le vaisseau sanguin et la couche de peau lorsque la partie de guidage est résorbée au fil du temps. Le système comprend un dispositif d'accès vasculaire pouvant être configuré pour avoir d'abord une force pour pénétrer à travers une couche de tissu, avoir ensuite une flexibilité pour se conformer au tissu environnant sous la couche de peau ; et une partie de guidage qui peut être résorbable, l'entrée comprenant un plus grand diamètre par comparaison avec la sortie.
Patent WO-2014084796-A1 (WO)
Title: A wind turbine and method of initiating or impeding rotation thereof
Inventor: ETTANOOR THAPPALE MOHAN DASS
IPC: F03D11/00
Filed: 2013-11-27
Abstract: A wind turbine device is proposed. The wind turbine device has one or more blades for rotation about a hub in a first rotational direction driven by wind; an electrical power generation system for generating electrical power due to said rotation of the blades; one or more first reaction jets positioned on at least one of the blades, for discharging a gas in a direction to generate a reaction force which urges the blades to rotate in said first direction; a compressed gas generation system; a gas transmission system for transmitting compressed gas from the compressed gas generation system to the reaction jets; and a control system operative, at a time when the blades are stationary, to initiate transmission of air to said first reaction jets, to initiate rotation of said blades.
Patent SG-187426-A1 (SG)
Title: Certain chemical entities, compositions and methods
Inventor: REN PINGDA
Filed: 2009-01-05
Abstract: Chemical entities that modulate PI3 kinase activity, and chemical entities,phaimaceutical compositions, and methods of treatments of diseases and conditions associated with P13 kinase activity are described herein.(Figure 1)
Patent SG-188459-A1 (SG)
Title: Aqueous polishing compositions containing n-substituted diazenium dioxidesand/or n'-hydroxy-diazenium oxide salts
Inventor: NOLLER BASTIAN
Filed: 2011-09-06
Abstract: An aqueous polishing composition comprising (A) at least one water-soluble or water-dispersible compound selected from the group consisting of N-substituted diazenium dioxides and N'-hydroxy-diazenium oxide salts; and (B) at least one type of abrasive particles; the use of the compounds (A) for manufacturing electrical, mechanical and optical devices and a process for polishing substrate materials for electrical, mechanical and optical devices making use of the aqueous polishing composition.
Patent SG-189416-A1 (SG)
Title: Route planning method and apparatus
Inventor: PAUL BORIS
Filed: 2011-10-20
Abstract: The invention relates to a method for planning routes which each run along a plurality of locations and for each of which a sequence of locations is determined according to distances between the locations. The distances between first locations on a first route are stored in a memory in conjunction with the determination of the first route, and a subsequent, second tour is determined according to distances between locations on the second route which are stored in the memory and according to further distances between locations on the second route, wherein the further distances are supplemented in the memory. The invention also relates to an apparatus which is suitable for carrying out the method. The invention can be used, in particular, to plan routes for delivering and/or collecting items of mail.
Patent SG-189945-A1 (SG)
Title: Peptide-based in vivo sirna delivery system
Inventor: ROZEMA DAVID B
Filed: 2011-12-16
Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted me!ittm dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
Patent SG-190078-A1 (SG)
Title: Predicting progression to advanced age-related macular degeneration using a polygenic score
Inventor: BEHRENS TIMOTHY W
Filed: 2011-11-01
Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).
Patent SG-191679-A1 (SG)
Title: Novel synergistic effects
Inventor: LUTZ ROBERT J
Filed: 2009-06-16
Abstract: NOVEL SYNERGISTIC EFFECTSThe present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect. The therapeutic effectiveness of the combination is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate. The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent (s). The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate. In each case, such combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone.Figure lA
Patent SG-193793-A1 (SG)
Title: Method of identifying disease risk factors
Inventor: ROSES ALLEN D
Filed: 2009-08-11
Abstract: Method of Identifying Disease Risk FactorsAbstractProvided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOM M40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided.Fig. 1
Patent SG-193870-A1 (SG)
Title: Electronic counter measure system
Inventor: MANELA REUEL
Filed: 2011-04-06
Abstract: ELECTRONIC COUNTER MEASURE SYSTEMA tactical electronic counter measure system comprising a first retro-directional transceiver sub system, receiving signals at a first frequency band, and first retro directional transceiver re transmitting a signal at least substantially toward the direction from which the sources signal was received, and first retro directional transceiver sub system including a plurality of blade antennas and a controller, coupled with and first retro-directional transceiver, and controller controlling the activity of and first retro directional transceiver sub system, and controller further managing the missions of and first retro directional transceiver sub system.FIG. 1
Patent SG-194342-A1 (SG)
Title: Isolation and identification of glycosaminoglycans
Inventor: COOL SIMON MCKENZIE
IPC: A61K35/12
Filed: 2009-02-19
Abstract: ISOLATION AND IDENTIFICATION OF GLYCOSAMINOGLYCANS The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.Figure 1
Patent SG-194802-A1 (SG)
Title: Induction of immune tolerance by using methotrexate
Inventor: JOSEPH ALEXANDRA
Filed: 2012-05-03
Abstract: The invention provides methods for reducing undesired immune responses, such as anti- drug antibody (ADA) responses and other T- and/or B-cell-mediated immune responses, in patients by using treatment with methotrexate.
Patent WO-2018063096-A1 (WO)
Inventor: TEU KOON KIAT
IPC: A61L27/50
Filed: 2017-09-27
Abstract: Disclosed herein are elastic, bioresorbable encasements for medical implants, methods for making the same and uses thereof.
Patent WO-2020180253-A1 (WO)
Inventor: WIMALASEKERE SADHIRA
IPC: A41F15/00
Filed: 2020-03-05
Abstract: The invention provides a strap comprising an exposed face, said strap arranged for use with an undergarment, wherein the strap includes a pigment element, to provide a shading that corresponds to a skin tone, on the exposed face.
Patent WO-2022203603-A1 (WO)
Title: Polymère hydrosoluble pour empêcher une adsorption non spécifique
Inventor: WANG HONGLEI
IPC: C08L43/02
Filed: 2022-03-23
Abstract: La présente invention concerne un copolymère hydrosoluble qui empêche l'adsorption non spécifique de substances biologiques, telles que des protéines et analogues. Il s'applique principalement à des réactifs, des particules et analogues qui sont utilisés dans les diagnostics cliniques, les expériences biochimiques, les dispositifs médicaux et similaires.
Patent WO-2013002738-A1 (WO)
Title: Vanne électromagnétique commandant des composants de circuit hydraulique
Inventor: MAJDIC FRANC
IPC: F16K11/07
Filed: 2012-06-04
Abstract: L'invention concerne une vanne électromagnétique destinée à rediriger un fluide hydraulique et utilisée, en fonction de chaque signal reçu, pour commander le fonctionnement d'au moins un appareil intégré dans chaque circuit hydraulique à haute pression à usage unique, caractérisé par une pression nominale comprise entre 50 et au moins 150 bar, et caractérisé en ce que de l'eau seule, éventuellement combinée à des additifs antigel respectueux de l'environnement, doit être utilisée comme fluide hydraulique dans ledit circuit hydraulique, dans lequel la pression de fonctionnement doit être d'au moins 50 bar et peut atteindre au moins environ 250 bar. Ladite vanne électromagnétique comporte un carter (1) dans lequel est aménagée une chambre (3) prévue pour recevoir un organe (2) de redirection et chaque fluide hydraulique, c'est-à-dire l'eau dans la vanne considérée. Ledit carter (1) est muni d'au moins trois ouvertures (A, B, P, T) de communication, disposées de façon à correspondre à chaque fonction souhaitée de la vanne, ainsi que d'un électroaimant (4, 4') qui est disposé dans / sur ledit carter (1) et prévu pour coopérer avec ledit organe (2) de redirection. Selon l'invention, le carter (1) au moins dans la zone de la surface interne (30) d'étanchéité de la chambre (3) de diamètre (D 3 ), et ledit organe (2) de redirection au moins dans la zone de sa surface externe (20) d'étanchéité hydraulique de diamètre (D 2 ), sont tous deux constitués d'acier trempé, l'intervalle (C) entre ceux-ci, soit la demi-différence entre le diamètre caractéristique (D 3 ) de la surface (30) d'étanchéité de la chambre (3) et le diamètre caractéristique (D 2 ) de la surface (20) d'étanchéité de l'organe (2) de redirection devant être compris entre 1 μm et 5 μm au maximum.
Patent WO-2016043671-A1 (WO)
Title: Trigger mechanism for auto-loading weapon, and auto-loading manual weapon
Inventor: KURACINA JAROSLAV
IPC: F41A17/74
Filed: 2015-09-17
Abstract: The trigger mechanism of the auto-loading weapon enabling to select a suitable shooting operation by a single control element, which shooting operation is either single action/double action operation (SA/DA) with the safe hammer (7) activation having the possibility to lock the cocked hammer, or the exclusive double action operation (DAO). The trigger mechanism consist of the swivel (23), the main catcher (9.1 ) of the hammer and the auxiliary catcher (9.2) of the hammer, equipped with the means for the mutual collaboration and for the collaboration with the hammer (7), wherein the swivel (23) is placed in revolving and adjustable position, and it is controlled by the control element (22) on the weapon surface.
Patent TN-2010000221-A1 (TN)
Title: Radiation-selective absorber coating and absorber tube with radiation selective absorber coating
Inventor: THOMAS KUCKELKORN
IPC: F24J2/48
Filed: 2010-05-20
Abstract: The invention relates to a radiation-selective absorber coating in accordance with the preamble of patent Claim 1. The invention also relates to an absorber tube with such a radiation-selective coating, and to a method for operating a parabolic trough collector using such absorber tubes. Parabolic trough collectors are used for generating power in solar power plants.
Patent TN-2011000470-A1 (TN)
Title: Crystalline tripeptide epoxy ketone protease inhibitors
Inventor: PHIASIVONGSA PASIT
IPC: C07K5/08
Filed: 2011-09-19
Abstract: The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and relates pharmaceutical compositions.