baber/WOPTO huggingface dataset:
Patent PT-2014673-E (PT)
Title: Tumour-associated peptides which bind to mhc molecules
Inventor: RAMMENSEE HANS-GEORG
IPC: A61K39/00
Filed: 2003-03-27
Abstract: Tumor-associated peptides (I) having any of 79 sequences, reproduced, are new. (I) can bind to a Class I molecule of the human major histocompatibility complex (MHC). Independent claims are also included for the following: (1) nucleic acid (II) that encodes (I); (2) vector that contains (II); and (3) cell modified to express (I), by incorporation of (II) or the vector of (2). ACTIVITY : Cytostatic. MECHANISM OF ACTION : Vaccine; induction of cytotoxic T lymphocytes (CTL). Dendritic cells (0.5 million) were isolated from peripheral blood and incubated with peptide (1) at 50 mu g/ml for 2 hours, then washed and incubated with 2.5 million autologous peripheral blood mononuclear cells (PBMC) for 7 days. The cells were restimulated with interleukin-2 (1 ng/ml) on days 1, 3 and 5, then cytotoxicity tested against various cancer cells at effector:target ratio 30:1, in a standard 51chromium release assay. Typical specific lysis scores were over 30% for HCT 116 stomach cancer cells; over 60% for A498 renal cancer cells; about 40% for MEL1479 melanoma and about 50% for MCF-7 breast cancer cells. Tyr-Val-Asp-Pro-Val-Ile-Thr-Ser-Ile (1).
Patent PT-2368439-E (PT)
Title: Stick-shaped snack and method for producing the same
Inventor: DATE TAKAYUKI
IPC: A21C1/04
Filed: 2007-04-09
Abstract: The present invention relates to a stick-shaped snack comprising a stick-shaped pastry and a coating material coated over the surface of the stick-shaped pastry, the stick-shaped pastry being formed by preparing the string-like dough provided with a plurality of non-through cuts formed therein across the longitudinal direction and impregnated with lye, 
baking the resulting string-like dough being mounted on a heating surface, and cutting the baked string-like dough at the cuts, 
the maximum cross-sectional width of each stick-shaped pastry being 2.5 mm to 3.5 mm.
Patent PT-567975-E (PT)
Inventor: POLETTI GIORGIO
IPC: D06P7/00
Filed: 1993-04-26
Abstract: A process for dyeing composite synthetic material having a porous polyurethane matrix and a fiber reinforcement (e.g. nonwoven fabric, polyamide, polyethylene or polyester fibers) embedded in the matrix, and from which to produce a sheet product similar to natural leather. The entire section of the material, consisting of the porous matrix and reinforcement, is treated with dyeing substances (hot-polymerizable plastic resins with a water or organic base, pigments, premetallized azoic dyes) by alternately winding the composite material, in strip form, on and off two opposed rollers and through a tank containing a bath of the dyeing substances in solution or emulsion form, so as to feed the strip of composite material reciprocatingly through the bath. The rollers and tank may be housed in a pressurized container for operating at temperatures of over 100 DEG C. <IMAGE>
Patent PT-629199-E (PT)
Inventor: MACOR JOHN E
IPC: C07D417/14
Filed: 1993-03-03
Abstract: PCT No. PCT/US93/01667 Sec. 371 Date Aug. 19, 1994 Sec. 102(e) Date Aug. 19, 1994 PCT Filed Mar. 3, 1993 PCT Pub. No. WO93/18032 PCT Pub. Date Sep. 16, 1993   <IMAGE>  (I)  Compounds of the formula (I) where A represents a direct bond, C1-C4 alkyl, or C1-C4 alkenyl; n is 0, 1, or 2; W, X, Y, and Z are each independently oxygen, sulfur, nitrogen or carbon, provided that at least one of W, X, Y, or Z is nitrogen. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.
Patent PT-649601-E (PT)
Inventor: ANTENUCCI ROBERT N
IPC: A23L21/15
Filed: 1994-10-20
Abstract: A reduced calorie fruit spread comprising the gelled product of:     a. water;   b: fruit or fruit flavoring; c. one or more high intensity sweeteners selected from the group consisting of aspartame; saccharin; acesulfame-K; mixtures thereof; and mixtures of aspartame, saccharin, or acesulfame-K with sucralose;     d. low methoxy pectin or carrageenan;   e. carboxymethylcellulose;   f. guar gum; and g. locust bean gum. in
Patent PT-690864-E (PT)
Inventor: DUNN MICHAEL J
IPC: A61K31/545
Filed: 1994-03-07
Abstract: PCT No. PCT/US94/01862 Sec. 371 Date Sep. 11, 1995 Sec. 102(e) Date Sep. 11, 1995 PCT Filed Mar. 7, 1994 PCT Pub. No. WO94/20505 PCT Pub. Date Sep. 15, 1994Anhydrous and crystalline free acid form of the cephalosporin antiobiotic ceftiofur, processes for its manufacture, and pharmaceutical composition containing it are provided.   <IMAGE>
Patent PT-710243-E (PT)
Inventor: ANDERSSON LARS HENRIK HARALD
IPC: C07K7/16
Filed: 1994-06-22
Abstract: A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired cyclic compound through direct ion exchange chromatography as an integral part of the single process. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.
Patent PT-735890-E (PT)
Inventor: MALLEY SERGE D
IPC: A61K45/06
Filed: 1994-12-20
Abstract: A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideoxy-ribonucleoside excluding AZT and hydroxycarbamide.
Patent PT-765398-E (PT)
Inventor: MULE JAMES J
IPC: A01N63/00
Filed: 1995-03-09
Abstract: The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an enriched population of prethymic lymphoid-committed progenitor population lacking long-term hematopoietic reconstitution potential. Compositions enriched for the cells and populations of cells obtained therefrom are also provided by the invention. Methods of use of the cells are also included. Methods of genetically modifying the cells are provided as are cells obtained thereby.
Patent PT-726322-E (PT)
Inventor: SUNDREHAGEN ERLING
IPC: G01N33/542
Filed: 1993-01-22
Abstract: There is provided a method for assaying homocysteine in a sample, e.g. blood, plasma or urine, which comprises the steps of contacting said sample with a homocysteine converting enzyme other than SAH-hydrolase and at least one substrate for said enzyme other than homocysteine, and without chromatographic separation assessing a non-labelled analyte selected from a homocysteine co-substrate and the homocysteine conversion products of the enzymic conversion of homocysteine by said enzyme.
Patent PT-852869-E (PT)
Inventor: GORETA LUCAS
IPC: H04L27/30
Filed: 1996-09-25
Abstract: A method enabling two populations of persons, one being sedentary (for example a provider of long-distance services) and the other being nomadic (for example the customers of this provider of services) to exchange data in a sure and speedy manner, comprises the following steps: portable objects are placed at the disposal of the persons belonging to the nomadic population, these objects having the credit card format and being customized by specific identifiers for each person and for each card, the card is used to transmit at least partially encrypted DTMF type brief acoustic identification signals which are received by means of the microphone of a standard telephone set and processed by means of the standard telephone set so that the resulting signal can be transmitted, through a telephone or computer network, to the data-processing service of at least one of the persons of the sedentary population, the signals coming from the card are processed by means of a specific software program whose parameters are a function of the characteristics of the card, its conditions of use in combination with the microphone of the telephone set, characteristics of the communications network for signals of a particular type corresponding to the identification data transmitted, the signals are decrypted and the data elements obtained after decryption are compared with the data elements, in the possession of the data-processing service, for the identification of the card and the holder of the card.
Patent PT-918455-E (PT)
Inventor: WYNICK DAVID
IPC: A61P25/00
Filed: 1997-07-24
Abstract: This invention relates to galanin and its uses. In particular, the invention provides a knockout mouse which lacks a functional galanin gene. The mouse may be used to investigate the effects of galanin. <??>It has also been unexpectedly discovered that galanin antagonists may be used in the management of pain, particularly painful neuropathies, the supression of pain, in the supression of location, in the treatment of prolactinoma and in anaesthesia. Additionally, the use of galanin agonists may be used in the treatment of Alzheimer's disease, in improving memory and cognition and in the treatment of nerve damage, such as the promotion of nerve regeneration.
Patent PT-980219-E (PT)
Inventor: ZAKSENBERG ISSAC
IPC: A46B7/04
Filed: 1998-04-14
Abstract: The interdental brush has a quadrangular shaped handle portion with an angled brush head portion with a brush head cartridge attached at one end and a removable brush head holder at the other end. The brush head can fit in a contra-angle arrangement or co-directional arrangement to the angle of the handle and the brush head support. In addition, there is a positive grip handle with a projecting thumb finger grip. The removable brush head holder into which the brush head can fit provides a smaller interdental brush and one that can be used away from home.
Patent PT-1017892-E (PT)
Inventor: SUH MYUNG WON
IPC: D05B3/14
Filed: 1998-05-30
Abstract: An apparatus for binding a button-fixing thread running through a button sewed on a garment or other fabric, which is capable of winding a binding thread around the button-fixing thread by several turns in a safe, simple, easy and convenient manner while forming a twist with the binding thread at every turn, thereby not only preventing the button from being separated due to a loosening of the button-fixing thread during a strong washing operation or an operation of passing the button through a button slit formed in the garment, but also achieving an improvement in the binding operation and an improvement in the reliability in use. The apparatus includes a thread hooking plate adapted to hook a binding thread to be wound around a button-fixing thread, a twisting member adapted to twist the binding thread hooked by the thread hooking plate and to separate the twisted binding thread from the thread hooking plate after the thread hooking plate rotates by a predetermined angle, and a twist forming member fixedly mounted to an end of the second actuating shaft disposed in the vicinity of the twisting member, the twist forming member adapted to hook the binding thread twisted by the twisting member after the twisting member rotates by a predetermined angle, thereby forming a complete twist with the binding thread.
Patent PT-995336-E (PT)
Inventor: PICCALUGA PIERRE
IPC: H04R3/04
Filed: 1998-07-06
Abstract: The invention concerns a method which consists in using digital sampling of a live sound recording or of an original sound medium, which is copied then formatted into a multiple reproduction of the original sampling. In order to observe the original time base, the multiple reproduction of copies, leads to the multiple reproduction of the sampling speed of the new digital signal. The quantization parameter can be identical to the original, or be subjected to value scaling, or be in reciprocal value. An apparatus formatting digital audio signal acquires a reference sampling from a digital decoder, then multiplies its data by adjustable independent samplers managed by a common clock. A relay programs the regular and cyclical activities of the samplers, determining a new digital sound signal. Said signal can be smoothed for analog use by fragile transducers. This formatting process adapted for acoustic transducers, can be used for recording and as audio signal software for transferring sound data.
Patent PT-1071456-E (PT)
Inventor: AGSTERIBBE ETIENNE
IPC: A61P31/00
Filed: 1998-11-24
Abstract: The present invention relates to a vaccine containing at least one immunogen and an adjuvanting amount of B subunits of heat-labile enterotoxin characteristic of E. coli isolated from a non-human source. This vaccine is particularly suitable for induction of a protective response against said immunogen upon mucosal (e.g. intra-nasal) administration.
Patent PT-1098823-E (PT)
Inventor: MONEY JULIAN DAVID KYRLE
IPC: B65D81/34
Filed: 1999-07-19
Abstract: A food pack comprising a tray formed from card having a rectangular base with fold up side and end walls and a sheet of wrapping material extending over the tray and adhered to the side walls to receive a food item. The sheet is folded over the item across the tray and the folded ends of the sheet projecting from the ends of the tray are tucked between the base of the tray and the sheet extending across the base. The end walls of the tray have convexly curved fold lines with the base of the tray whereby the end walls of the tray are folded upwardly with respect to the base to enclose the wrapped food item with the side walls.
Patent IE-830233-L (IE)
Title: Imidazoles
IPC: C07D309/00
Filed: 1983-02-07
Abstract: Compounds of the formula: <IMAGE> wherein W is selected from the group consisting of <IMAGE> (I) <IMAGE> (II) <IMAGE> (III) R1CH2CH2OCH2 (IV) Wherein Q is hydrogen or -CH2OR1; Z is hydrogen or -OR1; n is 1 or 2; wherein R1 are the same or different radicals selected from the group consisting of hydrogen, and <IMAGE> where R2 is lower alkyl, aryl, or aralkyl; wherein the bond at positions 2' and 3' of structure I may be single or double; or it may be a C-nucleoside attached at 3' position of the sugar; X and Y are the same or different selected from the group consisting of hydrogen, an electron withdrawing group, and a group wherein X and Y taken together form a 6-membered carbocylic aromatic ring, are useful as radiosensitizing agents during x-ray radiotherapy of tumor cells.
[US4462992A]
Patent IE-43078-L (IE)
Title: Phenoxypropionic acid derivatives.
IPC: C07D213/67
Filed: 1976-02-09
Abstract: Compounds of the formula <IMAGE> I <IMAGE> II in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X4 and X5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X0 is O or OCH2CH2O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.
[US4072705A]
Patent IE-790359-L (IE)
Title: Ribbed polyethylene film
IPC: B29C48/10
Filed: 1979-04-02
Abstract: An extruded tube of high molecular weight high density polyethylene film is formed with a plurality of equally spaced apart ribs 11 and the film intermediate the ribs 11 is slightly stretched. The ribbed film 10 is formed using an extrusion die 12 of circular cross-section having at the in-use top end thereof a plurality of spaced apart fine cut grooves 13. <IMAGE>
[GB2045677A]
Patent IE-900371-L (IE)
Title: Modified release gemfibrozil composition
IPC: A61K9/26
Filed: 1990-02-01
Abstract: A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically acceptable (meth)acrylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
Patent IE-810483-L (IE)
Title: L-proline derivatives.
IPC: C07C61/20
Filed: 1981-03-05
Abstract: This invention relates to 1-[(2-acylthiocycloalkyl)carbonyl]-L-proline derivatives which are useful as antihypertensive agents and to a process for their preparation.
[US4496743A]
Patent IE-850546-L (IE)
Title: Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)¹piperazine derivatives
IPC: C07D317/12
Filed: 1985-03-05
Abstract: Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents.
[US4605655A]
Patent IE-900604-L (IE)
Title: Composition and process to enhance the efficacy of a fish¹vaccine
IPC: A23K20/10
Filed: 1990-02-19
Abstract: A process and composition to enhance the efficacy of a fish vaccine. A .beta.-1,3-glucan having a .beta.-1,3-linked main chain with .beta.-1,6-linked single glucose side chains is administered to a fish treated with the vaccine.
[CA1330303C]
Patent IE-870796-L (IE)
Title: Macrolide derivatives
IPC: C07H17/08
Filed: 1987-03-27
Abstract: This invention provides an improvement in the process for preparing C-20-amino-substituted derivatives of the macrolide antibiotics of the tylosin type by reductively aminating the C-20 aldehyde group in the parent antibiotic. The improvement comprises using formic acid as the reducing agent. The new process is less expensive and more amenable to scale-up than previously used processes, but is still selective.
[EP0240264A2]
Patent IE-890825-L (IE)
Title: Method of preparing solid lactulose
IPC: C13K13/00
Filed: 1989-03-15
Abstract: The invention relates to a method of preparing solid forms of administration of lactulose by evaporating lactulose syrup to a water content of at most 10%, preferably 2 to 6%, cooling the thick, evaporated syrup, grinding and sieving, or breaking the solid product.
Patent FI-824276-L (FI)
Inventor: APPEL STANLEY HERSH
IPC: C07G15/00
Filed: 1982-12-13
Abstract: The present invention is based on the discovery that amyotrophic lateral sclerosis (ALS), Parkinson disease and Alzheimer disease are due to lack of a disorder-specific neurotrophic hormone. Diagnosis may be accomplished by assaying hormones specific for a particular neuronal network or system: the motor neurotrophic hormones from muscle in the motor neural system may be used to diagnose and treat ALS, dopamine neurotrophic hormones from striatum in the nigrostriatal neural system may be used to diagnose and treat parkinsonism, and cholinergic neurotrophic hormones released from the cortex and hippocampus which are specific for cholinergic neurons of the nucleus basalis and septal nucleus may be used to diagnose and treat Alzheimer's disease. With tissue culture, the presence or absence of specific neurotrophic hormones can be assessed in ALS, parkinsonism, and Alzheimer disease, to see if there is a deficiency. The invention provides extracted and purified neurotrophic hormones specific to the particular neuronal network or system, to be injected in ALS and Alzheimer disease and in parkinsonism.
Patent FI-853058-L (FI)
Inventor: STREIBIG KURT
IPC: B66B23/22
Filed: 1985-08-09
Abstract: The cover arrangement for covering the balustrade sill or base of a transportion apparatus, such as an escalator of moving walkway equipped with a self-supporting vertically disposed balustrade carrier is elastically fixed to the bottom or sub-structure of the balustrade sill or base by means of pairwise arranged, self-adhesive interlocking strips or bands. For this type of fixing, neither screws or bolts nor welding work is required to be performed upon the cover arrangement, so that no screw or bolt heads are visible and there can be used for the covers or panels of the cover arrangement, without any additional expenditure, the most varied materials and surface properties. Each of the cover arrangements, which are divided into an inner cover or panel and an outer cover or panel, can have their individual covers or panels removed, for maintenance purposes or otherwise, independently of the other cover arrangements and their covers or panels without the use of special tools and can be just as easily re-mounted.
Patent IE-871346-L (IE)
Title: Aqueous suspension concentrates
IPC: A01N43/70
Filed: 1987-05-22
Abstract: The present invention relates to stable aqueous suspension concentrates or aqueous flowable compositions of the low-melting dinitroaniline pesticide, pendimethalin, alone or in combination with secondary pesticide(s) melting at temperatures greater than 70<o>C or pesticides which are water soluble. Preferred compositions of the invention comprise on a weight to volume basis, about 5.0% to 50.0% pendimethalin; about 0% to 50.0% of one or more secondary pesticide(s); about 3.0% to 30.0% of coformulants, such as surfactants, dispersing agents, wetting agents, antifreezing agents, antifoaming agents, thickening agents, gums, preservatives and 20.0% to 92.0% water. The stable compositions of the invention are readily prepared by forming an emulsion of molten pendimethalin in water containing the coformulants, surfactants, dispersing and/or wetting agents, antifoaming agents and suspending agents. This emulsion has an average droplet size in a range of less than 2 microns to about 10 microns, preferably 2 microns to 6 microns. This is then cooled and optionally milled to obtain an average particles size of suspended particles of less than 20 microns, preferably less than 5 microns.
Patent IE-801454-L (IE)
Title: Cabinet assembly
IPC: F16B12/04
Filed: 1980-07-11
Abstract: A foldable structure (2) and a method of manufacturing a foldable structure which, when folded produces a curved edge or corner. The structure comprises two panel members (32,34) having a respective edge region (18,20) which are adjacent and are spaced apart. Each edge region has a shoulder (8,10) and a curved portion (12,14). A flexible elongated bridging piece (22) is located between the shoulders (8,10) and defines a foldable region. A flexible lamina (24) covers a respective face of the panel members (32,34) and the flexible bridging piece (22).
[US4387128A]