Patent AU-2014202276-A1 (AU)
Title: Delivery of active agents
Inventor: RICHARDSON PETER
IPC: A61K38/26
Filed: 2014-04-28
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date (10) International Publication Number 30 April 2009 (30.04.2009) PCT W O 2009/055742 A2 (51) International Patent Classification: Not classified (US). LEONE-BAY, Andrea [US/US]; 297 Florida Hill Road, Ridgefield, CT 06877 (US). (21) International Application Number: PCT/US2008/081221 (74) Agents: HU, Yi-kang et al.; K & 1 Gates LLP, 1900 Main Street, Suite 600, Irvine, CA 92614-7319 (US). (22) International Filing Date: 24 October 2008 (24.10.2008) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, (26) Publication Language: English EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, (30) Priority Data: IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (30) 82,368 Port Dr 2LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, 60/982,368 24 October 2007 (24.10.2007) US MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, 60/985,620 5 November 2007 (05.11.2007) US RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, 61/022,74 18 Janurc 2008 (1.01.2008) US TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 61/052,127 9 May 2008 (09.05.2008) US 61/094,823 5 September 2008 (05.09.2008) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, MANNKIND CORPORATION [US/US]; 28903 North ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), Avenue Paine, Valencoa, CA 91355 (US). European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, H-U, IE, IS, IT, LT, LU, LV, MC, MT, NL, (72) Inventors; and NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, (75) Inventors/Applicants (for US only): BAUGHMAN, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Robert, A. [US/US]; 75 Nod Road, Ridgefield, CT 06877 (US). RICHARDSON, Peter [GB/US]; 115 Linvale Published: Road, Ringoes, NJ 08551 (US). COSTELLO, Donald without international search report and to be republished [US/US]; 11 Andover Avenue, Bridgewater, NJ 08807 upon receipt of that report (54) Title: DELIVERY OF ACTIVE AGENTS (57) Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.