Patent FR-2964866-A1 (FR)
Title: Use of new of known at least one ortho-diphenol compound as antidandruff agent to treat dandruff associated with the proliferation of Malassezia yeasts on the scalp
Inventor: RAMOS STANBURY LAURE
IPC: A61K8/37
Filed: 2010-09-22
Abstract: Use of at least one ortho-diphenol compound (I) and their salts and solvates as antidandruff agent, is claimed. Use of at least one ortho-diphenol compound of formula (I) and their salts and solvates as antidandruff agent, is claimed. R1-R4 : H, halo, carboxyl group (COOH), 1-6C alkyl carboxylate group of formula (COOR), amine group of formula (NRR1a), linear 1-40C or branched 3-40C alkyl group (saturated) (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group, OH or NRR1a), linear 2-40C or branched 3-40C (poly)alkenyl group having one or more unsaturations (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group, OH or NRR1a), or aryl group (optionally substituted by one or more 1-30C alkyl group optionally one or more non-adjacent carbon atoms are replaced by divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-), preferably R1, R3 and R4 is H; R7 : H or 1-6C alkyl, optionally substituted by one or more 1-4C alkyl and/or OH; and R, R1a : H or 1-6C alkyl group. Provided that at least one of R1-R4 is different from H. An independent claim is included for ortho-diphenol compound of formula (Iaa) or (Ibb) and their salts or solvates. R8 : H or 1-4C alkyl, preferably H; Y1 : saturated linear 1-10C or branched 2-10C alkyl group; Z1 : linear 15-30C or branched 15-30C alkyl group (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group or OH), or linear 15-30C or branched 15-30C (poly)alkenyl group (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group, or OH); Z2 : linear 9-30C or branched 9-30C alkyl group (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group or OH), or linear 9-30C or branched 9-30C (poly)alkenyl group (optionally one or more non-adjacent carbon atoms are replaced by a divalent radical comprising -NR7, -S-, -O- and/or -C(O)-, preferably -OC(O)-, -C(O)-O-, -C(O)-NR7-, -NR7-C(O)- and/or -NR7-C(O)-NR7-, and optionally substituted by one or more OH and/or aryl group, which is optionally substituted by one or more 1-6C alkyl group, or OH); and R7 : H or 1-6C alkyl, optionally substituted by one or more 1-4C alkyl and/or OH. Provided that (I) excludes (E)-3-(3,4-dihydroxy-phenyl)-N-((Z)-octadec-9-enyl)-acrylamide. [Image] [Image] ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.