baber/WOPTO huggingface dataset:
Patent CA-2362301-A1 (CA)
Title: Multi-purpose valve
Inventor: ROY SUMIT
IPC: A61F2/24
Filed: 2000-02-16
Abstract: The invention relates to a multi-purpose valve characterized in that it comprises a band of a thermodynamic metal alloy with shape memory, with a memorised shape and a transition temperature which lies in the range for the  normal body temperature of a mammal. The strip has a linear shape below the transition temperature and assumes the memorised shape above the transition temperature. The memorised shape is preferably a conical spiral with a close d tip, with the result that above the transition temperature range the valve will become a conical spiral.
Patent CA-2364713-A1 (CA)
Title: Method for producing a flat preparation with at least one single-layer ingredient matrix
Inventor: ROREGER MICHAEL
IPC: A01N25/34
Filed: 2000-02-22
Abstract: A process for producing a sheetlike formulation comprising at least one single-layer active substance matrix for the controlled release of active substance to the vicinity of the application site, the active substances being selected from crop protection agents, biocides, fertilizers, plant strengtheners, cosmetic active principles and fragrances, is characterized in that the matrix is produced using at least two layers (1, 2), identical in composition, of a base material in the following temporally and spatially separate steps:   - provision of two prefabricable layers (1,2), identical in composition, of a base material, - application of active substance to at least one of the two layers (1,2), - placement of the two layers (1,2) atop one another so as to enclose the active substance applied, and irreversible joining under pressure to form a laminate, - storage of the laminate for predeterminable duration under defined conditions, with migration of the active substance into the base layers (1,2), and connection at their interfaces to form a homogenous matrix featuring substantially uniform dispensation of active substance.
Patent CA-2367751-A1 (CA)
Title: Coated membrane with an aperture for controlled atmosphere package
Inventor: GONG SANNAI
IPC: B65D85/34
Filed: 2000-03-15
Abstract: A coated membrane for use in controlling the oxygen and carbon dioxide ratio inside of a package that holds respiring produce such as fruits, vegetables or flowers. The coated membrane comprises a porous substrate, such as a polypropylene film, and has an oxygen permeance in the range of 5,000 to 30,000,000 cc/100 in2-atmosphere-day. The substrate is coated with a material that is substantially impermeable to oxygen, such as an acrylic emulsion, so that the amount of substrate surface area covered with the coating causes a decrease in the oxygen permeance of the substrate. The coating is applied to the substrate using a flexographic or rotogravure or rotary silkscreen process. An aperture of approximately 0.15 mm is placed in the coated membrane to allow the internal pressure to approximate the external pressure without a significant loss of relative humidity.
Patent CA-2368197-A1 (CA)
Title: Procedes d'identification de pharmacophore contenant des molecules provenant d'une banque virtuelle
Inventor: ROSENFELD RAKEFET
IPC: C07K1/04
Filed: 2000-04-12
Abstract: L'invention concerne un procédé permettant de constituer une molécule pharmaceutiquement et potentiellement utile qui présente un pharmacophore prédéfini associé à une activité biologique voulue. Le pharmacophore est en premier lieu utilisé pour passer au crible une banque virtuelle d'échafaudages, décrits par des coordonnées tridimensionnelles, afin d'identifier au moins un échafaudage susceptible d'afficher potentiellement des substituants qui, seuls ou avec des atomes d'échafaudage, contiennent un pharmacophore. Le processus de criblage consiste à placer d'abord des rotamères provenant d'une banque virtuelle de substituants sur chaque point de fixation de chaque échafaudage, puis d'examiner la banque combinatoire virtuelle (BCV) obtenue en fonction d'au moins un paramètre requis par le pharmacophore. De préférence, les BCV sont filtrées à l'aide d'une série de filtres de complexité croissante afin d'éliminer les échafaudages incompatibles avec le pharmacophore choisi et d'identifier les échafaudages susceptibles d'afficher des substituants compatibles avec le pharmacophore, voire les rotamères substituants correspondants. Les échafaudages compatibles et les substituants correspondants sont combinés de façon à représenter au moins une molécule contenant le pharmacophore voulu. En conséquence, le procédé permet de cribler efficacement un très grand nombre d'entités moléculaires pour la présence d'un pharmacophore voulu.
Patent CA-2368553-A1 (CA)
Title: Drop centering device
Inventor: BERGE BRUNO
IPC: G02B3/14
Filed: 2000-03-24
Abstract: A method for centering a drop of liquid (2) on a given point on a surface (4).  The inventive method consists in forming a bell-mouthed recess (6), whereby said recess has a curvature at any point at the limit of contact between the drop and the recess that is lower than or opposite to the curvature of a circle (TC) that is tangent to the surface of the recess to said point and at a symmetrical point (CP2) of said surface.
Patent CA-2369303-A1 (CA)
Title: Method and composition for the treatment of cancer
Inventor: PARDEE ARTHUR B
IPC: A61K38/00
Filed: 2000-04-14
Abstract: We have surprisingly discovered that the administration of a G1 and/or S phase drug such as .beta.-lapachone in combination with a G2/M drug such as a taxame derivative such as paclitaxel resulted in an unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a .beta.-lapachone, or a derivative or analog thereof.
Patent CA-2369325-A1 (CA)
Inventor: RECOQUILLE CHRISTELLE
IPC: C08J5/00
Filed: 2002-01-28
Abstract: A transparent polyamide composition comprises: (A) a semi-crystalline polyamide; (B) 5-40 wt.% amorphous polyamide; (C) 0-40 wt.% of a flexible polyamide; (D) 0-20 wt.% compatibilizing agent; and (E) 0-40 wt.% of a flexible modifier. The total of (C)+(D)+(E) is 0-50 wt.%. The total of all components is 100 wt. %. (D) compatibilizes (A) and (B). A transparent polyamide composition comprises: (A) a semi-crystalline polyamide; (B) 5-40 wt.% amorphous polyamide; (C) 0-40 wt.% of a flexible polyamide; (D) 0-20 wt.% compatibilizing agent; and (E) 0-40 wt.% of a flexible modifier. The total of (C)+(D)+(E) is 0-50 wt.%. The total of all components is 100 wt. %. (D) compatibilizes (A) and (B). Polyamide (B) is the result of condensation of either at least one cycloaliphatic or aliphatic diamine and at least one aliphatic or cycloaliphatic diacid, one at least or the diamines or diacids being cycloaliphatic, or of an  alpha - omega -amino cycloaliphatic carboxylic acid or of a combination of these and optionally one or more  alpha - omega -amino carboxylic acids or corresponding lactam, aliphatic diacid or aliphatic diamine. Independent claims are included for objects consisting of the composition such as plates, films, sheets, tubes, sections obtained by injection molding and especially films and sheets for gluing onto skis and for objects coated with a protective layer of the composition and decorated by, e.g. sublimation.
Patent CA-2370365-A1 (CA)
Inventor: YOSHITOMI SUMIE
IPC: A61P1/16
Filed: 2000-04-27
Abstract: A cell line obtained from a human liver-origin incubated cell line as a host  and showing stable expression of a number of human cytochromes P450, etc. Because of showing stable expression of human cytochromes P450 CYP1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4, the human liver-origin incubated  cell line is useful in, for example, analyzing an enzyme participating in th e metabolism of a foreign matter in vivo or an endogenous substrate.
Patent CA-2370993-A1 (CA)
Inventor: KAMO TOMOICHI
IPC: H01M8/02
Filed: 2002-02-07
Abstract: The object of this invention is to provide an electrode for a polymer electrolyte fuel cell, a separator therefor, a polymer electrolyte fuel cell and a generating system, which electrode is simplified in structure, have high handling property, can be transferred precisely to a predetermined position, and enables automation of a production process.        This invention provides an electrode for a polymer electrolyte fuel cell which electrode contains: a solid polymer electrolyte membrane; electrode layers formed respectively on both faces of the electrolyte membrane; two reinforcing members which cover respective outer surfaces of the electrode layers; and a sealing member which covers, extending from respective end faces to respective end parts of the reinforcing members, whole peripheries of the two reinforcing members, wherein the electrolyte membrane, the electrode layers and the reinforcing members are integrally formed by the sealing member.
Patent CA-2371976-A1 (CA)
Inventor: COX PETER
IPC: A61P25/28
Filed: 2000-02-24
Abstract: L'invention porte sur une nouvelle famille de protéines sous-unité .beta. du canal sodique potentio-dépendant et en particulier sur les sous-unités de l'homme et du rat désignées collectivement par .beta.3 en raison de leur structure très voisine. L'invention porte également sur l'utilisation des polypeptides sous-unité .beta.3 (ou de leurs fragments) et sur les acides nucléiques codant pour elles, à des fins thérapeutiques, diagnostiques ou de criblage.
Patent CA-2375349-A1 (CA)
Inventor: BORDIGNON CLAUDIO
IPC: A61P35/00
Filed: 2000-05-24
Abstract: A method for antigen transfer to dendritic cells, comprising cocultivation o f DCs with cells transfected with, or expressing the, desired antigens.</SDOAB >
Patent CA-2375533-A1 (CA)
Inventor: FRIGG ROBERT
IPC: A61B17/70
Filed: 1999-07-07
Abstract: A bone screw (2; 14) with a screw shank (4; 21) to be anchored concentric to a longitudinal axis (5;  24) of the screw in a bone or bone part, and with a screw head (3; 22), characterized in that the bone screw (2; 14) has, between the screw head (3; 22) and the screw shank (4; 21), a disk-shaped collar (6; 23) which is concentric to the longitudinal axis (5; 24) of the screw and whose diameter is greater than the diameter of the screw shank (4; 21).   A device for osteosynthetic bone fixation with A) at least one such bone screw (2; 14); and B) at least one plate-shaped, prismatic or cylindrical fixation body (1; 15) which has at least one bore (7; 17) with a central axis (8; 16) for receiving the bone screw (2; 14), an underside (9; 19) toward the screw shank, and an upper side (11; 18) toward the screw head, C) the bore (7; 17) comprising a portion (10;  26) tapering toward the underside (9; 19), and D) the diameter d of the collar (6; 23) being dimensioned such that the collar (6; 23), in the concave portion (10; 26) of the bore (7; 17), can be made to bear on the wall (12; 27) of the bore (7; 17) at different angles between the longitudinal axis (5;  24) of the screw and the central axis (8; 16).
Patent CA-2379362-A1 (CA)
Inventor: COLLINS PETER L
IPC: C12N15/86
Filed: 2000-07-12
Abstract: L'invention concerne des virus syncytiaux respiratoires recombinés (RSV) qui expriment une ou plusieurs molécules modulatrices immunitaires. Le virus recombiné est modifié par l'ajout ou par la substitution d'une séquence polynucléotidique codant pour la molécule modulatrice immunitaire, qui est de préférence une cytokine. L'introduction de la cytokine permet d'accroître, de diminuer ou d'améliorer autrement des aspects de la biologie virale et/ou les réponses immunitaires d'hôte à RSV, et facilite ainsi l'utilisation vaccinale du virus. Les cytokines s'utilisant dans l'invention comprennent notamment, mais pas exclusivement, l'interleukine 2 (IL-2), l'interleukine 4 (IL-4), l'interleukine 5 (IL-5), l'interleukine 6 (IL-6) ou l'interleukine 18 (IL-18), le facteur de nécrose des tumeurs (TNF) alpha, l'interféron gamma (IFN) et le facteur de stimulation des colonies de granulocytes-macrophages (GM-CSF). Le polynucléotide ou la molécule modulatrice immunitaire est de préférence ajouté(e) ou substitué(e) dans le génome ou l'antigénome viral recombiné, généralement à un site intergénique ou à une autre site non codant, comme gène séparé, mais peut être exprimé autrement, par exemple comme protéine de fusion.
Patent CA-2379671-A1 (CA)
Inventor: SINDERBY CHRISTER
IPC: A61M16/00
Filed: 2000-07-27
Abstract: On utilise une commande de gain et un procédé de contrôle de la valeur d'un gain en conjonction avec un réseau d'électrodes pour détecter un signal représentant la sortie de la pulsion respiratoire d'un patient pendant l'inspiration et un ventilateur prévu pour assister l'inspiration du patient. La commande de gain comprend une entrée qui reçoit le signal représentant la sortie de la pulsion respiratoire ; un comparateur qui détermine si le signal représentant la sortie de la pulsion respiratoire est supérieur ou inférieur à un signal d'entraînement cible; et une unité d'ajustement du gain qui augmente la valeur d'un gain lorsque l'amplitude d'un signal représentant la sortie de la pulsion respiratoire est supérieure à l'amplitude d'un signal d'entraînement cible et qui diminue la valeur de ce gain lorsque l'amplitude du signal représentant la sortie de la pulsion respiratoire est inférieure à l'amplitude du signal d'entraînement cible. Le gain est appliqué au signal représentant la sortie de la pulsion respiratoire pour produire un signal représentant la sortie de la pulsion respiratoire amplifié utilisé pour commander le ventilateur pulmonaire. L'avantage de la ventilation à entraînement cible réside dans le fait que ce mode de ventilation ne dépend pas de la pression, ni des mesures de flux et de volume. Une ligne de ventilation qui fuit a pour effet de modifier l'entraînement respiratoire, ce qui provoque une modification de l'aide ventilatoire qui permet de renvoyer l'entraînement respiratoire à son niveau cible. De même, des changements de l'état métabolique ou patho-physiologique du patient qui provoquent à un entraînement respiratoire altéré seront compensés.
Patent CA-2381130-A1 (CA)
Title: Filter for removing contaminants from an enclosure
Inventor: DAUBER EDWIN
IPC: B01D71/30
Filed: 2000-08-23
Abstract: The invention relates to a device for filtering contaminants, such as particulates and vapor phase contaminants, from a confined environment such as electronic or optical devices susceptible to contamination (e.g. computer disk drives) by incorporating multiple filtration junctions into a unitary filter. Filtration functions include a combination of inlet, or breather, filter and recirculation filter. Moreover, adsorbent functions can be added to the filter depending on desired functionality within the enclosure.
Patent CA-2383216-A1 (CA)
Title: Mechanical seal assembly with improved fluid circulation
Inventor: YOUNG LIONEL ALLAN
IPC: F16J15/34
Filed: 1999-10-14
Abstract: A seal assembly for a mechanical seal includes a rotatable shaft with at least one mechanical seal disposed about the shaft, the seal having a rotatable face coupled to the shaft and a stationary face, wherein the respective faces of the seal are in contact with one another, and a chamber for holding a cooling fluid, disposed about the shaft and in communication with the faces of the seal, and a closed loop fluid path disposed about the outer diameter of the shaft, preferably or in a non linear manner, in fluid communication with the chamber, for circulating fluid about the seal faces.
Patent CA-2383777-A1 (CA)
Inventor: CHALOUPKA HEINZ
IPC: H01P1/202
Filed: 2000-08-26
Abstract: The invention relates to a high-frequency band pass filter assembly, comprising a master resonator and at least one stop-band resonator which is coupled thereto. The aim of the invention is to construct a filter structure  in such a way, that with a given number of poles, the highest possible numbe r of transmission zero positions occur in the stop bands, whereby in relation to known resonator configurations, no overcoupling is used between non-adjoinin g resonators. To this end, the stop-band resonator(s) is/are coupled to the master resonator in such a way that the stop-band resonator generates both transmission zero positions and transmission pole positions in tandem with t he master resonator.
Patent CA-2386900-A1 (CA)
Inventor: DYATLOV VALERY ALEXANDROVICH
IPC: C08J9/16
Filed: 2000-10-02
Abstract: La présente invention concerne des mousses alvéolaires comprenant un matériau polymère dont la structure contient des zones élastiques amorphes de taille nanométrique, renforcées par des domaines cristallins de nanocristaux auto-assemblés.
Patent CA-2388310-A1 (CA)
Inventor: DUMAIS LOUIS-CHARLES
IPC: G06F9/44
Filed: 2002-05-27
Abstract: Une interface géométrique graphique universelle pour les langages de programmation. L'interface est constituée d'une représentation graphique arborescente du co de source à l'aide de formes géométriques (solides ou figures) qui sont associées aux différentes composantes d'un langage. Chaque composante d'un langage est associée à une forme géométrique (solide ou figure) qui lui est propre. Les différentes caractéristiques de la représentation géométrique sont sauvegardées en utilisant des commentaires dans le code source. A l'aide d'un navigateur(sous forme de logiciel), un utilisateur peu t visualiser et comprendre la structure d'un code source rapidement par l'observation des différents liens entre les formes géométriques (solides ou figures) à l'aide de la structure arborescente. La représentation est valide autant pour des langages de bas niveau (assembleurs x86, PPC...) que pour des langages de haut niveau (C++, Java... ). L'utilisation de la représentation à l'aide de figures géométriques génère l es avantages suivant: - Une facilité d'apprentissage de la programmation; - Une simplification des mécanismes régissant un code source; - Une simplification des mécanismes régissant un programme; - Une amélioration du rendement de travail chez un programmeur; - Une facilité de présentation d'un code source à un auditoire; - Une facilité de gestion de projets complexes de programmation.
Patent CA-2388486-A1 (CA)
Inventor: WHEELER STANLEY T
IPC: D06F58/48
Filed: 2002-05-31
Abstract: An arrangement for drying material in a selected drying location by a heated and flowing drying stream wherein the temperature and relative humidity levels of the drying stream are sensed upstream and downstream of such selected drying location and are relatively and comparatively controlled to arrive at a selected treated material moisture with comparatively minimal energy input.
Patent CA-2389475-A1 (CA)
Inventor: FIRLOTTE DAVID
IPC: A47J37/07
Filed: 2002-03-29
Abstract: The Barbeque Stone is a replacement for lava rock. It consists of four stones know as the left stone, right stone and two center stones. They are placed inside the barbeque on the bottom grill where the lava rock is normally placed. The stones are placed on the grill, centered to the front and back of the barbeque. This will leave a gap between the front of the stone and the front wall of the barbeque and also a gap between the back of the stone and the back wall of the barbeque. The number of barbeque stones that are placed on the grill depends on the size of the barbeque. The stones act as a heat convector as well as a protective shield for the burner from dripping juices and fat. After the barbeque is lit, the stones get hot and the heat dissipates from the stones to the top of the barbeque. The hot air then travels in a circular motion around the stones through the gaps in the front and back The stones are designed thicker in size on the front of the stone and thinner at the back of the stone so that the excess juice and fat will run to the back of the stone and fall to the bottom of the barbeque away from the burner and out the drain hole in the bottom of the barbeque.
Patent CA-2389745-A1 (CA)
Title: Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
Inventor: STORER RICHARD
IPC: A61K31/415
Filed: 2000-11-03
Abstract: In accordance with the present invention there is provided a method for treating or preventing a Flaviviridae viral infection in a host comprising administering a therapeutically effective amount of at least one compound of  formula (I) or (II) or a pharmaceutically acceptable salt thereof, wherein R a, R, Z and Y are defined in the application.
Patent CA-2390358-A1 (CA)
Title: Process for rapid solution synthesis of peptides
Inventor: HAASNOOT CORNELIS ALBERT GRUSO
IPC: C07K2/00
Filed: 2002-07-18
Abstract: The present invention relates to a process for rapid solution synthesis of a  peptide, the process comprising repetitive cycles of steps (a)-(d): (a) a coupling step, using an excess of an activated carboxylic component to  acylate an amino component, (b) a quenching step in which a scavenger is used to remove residual activat ed carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, (c) one or more aqueous extractions and optionally, (d) a separate deprotection step, followed by one or more aqueou s extractions, characterised in that the process comprises at least one step (b), referred to as step (b'), in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. During the process of this invention the growing peptide need not be isolate d until the final peptide sequence has been obtained. This highly efficient process is useful for the production of oligo- and polypeptides of high purity.
Patent CA-2391622-A1 (CA)
Title: Inhibiting gene expression with dsrna
Inventor: ZERNICKA-GOETZ MAGDELENA
IPC: C12N15/85
Filed: 2000-11-17
Abstract: The present invention relates to the specific inhibition of gene expression in mammals by bringing the target gene into contact with double stranded RNA (dsRNA).
Patent CA-2393659-A1 (CA)
Title: Multimeric forms of tnf superfamily ligands
Inventor: KORNBLUTH RICHARD S
IPC: C07K14/705
Filed: 2000-03-20
Abstract: A method for constructing stable bioactive fusion proteins of the difficult to express tumor necrosis factor superfamily (TNFSF), and particularly members CD40L (CD154) and RANKL/TRANCE, with collectins, particularly pulmonary surfactant protein D (SPD) is described. Single trimers of these proteins la ck the full stimulatory efficacy of the natural membrane forms of these protein s in many cases. The multimeric nature of these soluble fusion proteins enable s them to engage multiple receptors on the responding cells, thereby, mimickin g the effects of the membrane forms of these ligands. For CD40L-SPD, the resulting protein stimulates B cells, macrophages, and dendritic cells, indicating its potential usefulness as a vaccine adjuvant. The large size of  these fusion proteins makes them less likely to diffuse into the circulation , thereby limiting their potential systemic toxicity. This property may be especially useful when these proteins are injected locally as a vaccine adjuvant or tumor immunotherapy agent to prevent them from diffusing away. I n addition, these and other TNFSF-collecting fusion proteins present new possibilities for the expression of highly active, multimeric, soluble TNFSF  members.
Patent CA-2393743-A1 (CA)
Inventor: CORTEZ FELINO V JR
IPC: A61M16/06
Filed: 2000-12-08
Abstract: L'invention concerne un dispositif servant à introduire de l'air réchauffé et humidifié dans les voies respiratoires d'un patient humain afin d'effectuer un traitement thérapeutique des voies respiratoires. Ce dispositif comprend une unité d'alimentation et un tube d'application qui peut être accouplé de façon détachable à cette unité d'alimentation. Elle concerne également des procédés de traitement thérapeutique des voies respiratoires.