baber/WOPTO huggingface dataset:
Patent CR-20180246-A (CR)
Title: Prevención, tratamiento y reversión de enfermedad usando cantidades terapéuticamente efectivas de ácidos grasos activados
Inventor: JORKASKY DIANE;
IPC: C11D1/28
Filed: 2016-10-03
Abstract: Varias modalidades de esta invención se dirigen a composiciones y métodos farmacéuticos para tratar enfermedades, incluyendo glomeruloesclerosis segmentaria focal o hipertensión arterial pulmonar. Las composiciones de tales modalidades incluyen ácidos grasos activados tales como ácidos grasos sustituidos con alquilo, ácidos grasos ceto y ácidos grasos nitro. Los métodos de varias modalidades incluyen administrar una cantidad efectiva de ácido 10-nitro-9(E)-octadec-9-enoico para tratar tales enfermedades
Patent CR-20200004-A (CR)
Title: Interleukin-2 muteins for the expansion of t-regulatory cells
Inventor: KANNAN GUNASEKARAN
IPC: C07K14/55
Filed: 2014-03-14
Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
Patent CR-20200114-A (CR)
Title: Pyrazolopyrimidinone compounds and uses thereof
Inventor: CIBLAT STEPHANE
IPC: C07D498/04
Filed: 2018-09-14
Abstract: The present invention relates to pyrazolopyrimidinone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Patent EC-SP083351-A (EC)
Title: Composiciones farmacéuticas
Inventor: MATTHEWS GRAHAM PAUL
IPC: A61P31/00
Filed: 2008-07-04
Abstract: Se describen composiciones de N-benzoil-estaurosporina espontáneamente dispersables para administración oral, que tienen altos niveles de biodisponibilidad, y una variabilidad reducida de los niveles de biodisponibilidad de N-benzoil-estaurosporina, así como su preparación y uso en un tratamiento médico.
Patent EC-SP088668-A (EC)
Title: Sistema de administracion de plaguicidas
Inventor: KABANOV ALEXANDER V
IPC: A01N25/00
Filed: 2008-08-08
Abstract: Se revela un sistema de administración de plaguicida. El sistema está basado en una micromezcla que comprende (a) un compuesto anfifílico que contiene por lo menos un grupo hidrófilo y por lo menos un grupo hidrófobo y (b) un segundo compuesto. También se revelan composiciones basadas en la micromezcla y métodos para usar las composiciones para controlar plagas.
Patent EC-SP089022-A (EC)
Title: Formula para infantes para desarrollo temprano
Inventor: RUEDA CABRERA RICARDO
IPC: A23L33/00
Filed: 2008-12-29
Abstract: La primera incorporación del presente invento se dirige a las formulas para infantes que incluyen por lo menos 6.5 g/L, según la dosis, de concentrado de proteína de suero enriquecido, y por lo menos aproximadamente 0.13% de ácido docosahexaenoico por peso de ácidos grasos totales, y por lo menos aproximadamente 0.25% de ácido araquidónico por peso de los ácidos grasos totales. Las formulas también pueden incluir en base de alimentación por lo menos aproximadamente 5 mg/L de gangliósidos, por lo menos aproximadamente 150 mg/L de fosfolípidos, y por lo menos aproximadamente 70 mg/L de total ácido siálico con por lo menos aproximadamente 2.5% como ácido siálico adherido a los lípidos, todo lo cual se puede probar, de manera total o en parte, a partir del concentrado de proteína de suero. También se revela métodos para el desarrollo del cerebro, migración neural y desarrollo cognitivo en infantes por administración de fórmulas infantiles durante los primeros 2 y 4 meses de vida, preferiblemente como un solo suero de nutrición.
Patent EC-SP930980-A (EC)
Title: Derivados de la pirimidina que tengan un substituto de difluorobuteniltio
Inventor: ZENECA LIMITED
IPC: C07D498/04
Filed: 1993-09-10
Abstract: En donde R1 es -S(0)n CH2CH2CH=CF2; n es seleccionado de 0,1 y 2; R2, R3 y R4 son independientemente seleccionados de hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, alquilocicloalquilo, arilo opcionalmente sustituido, ariloalquilo opcionalmente sustituido, ariloxi opcionalmente sustituido, arilalcoxi opcionalmente sustituido, alcoxi, alqueniloxi, alquiniloxi, hidroxialquilo,alcoxialquilo, alquiltio, alqueniltio, alquiniltio, haloalquilo, haloalquenilo, haloalquinilo, haloalcoxi, haloalqueniloxi, haloalquiniloxi, haloalquiltio, haloalqueniltio, haloalquiniltio, halógeno, hidroxi, ciano, nitro, -NR5R6, -NR7COR8, -NR9SO2R10, -N(SO2-R11) (SO2-R12), -COR13, -CONR14R15, -COOR16, -OCOR17, -OSO2R18, -SO2NR19R20, -SO2R21, -SOR22, -CSNR23R24, -SiR25R26R27, -OCH2CO2R28, -OCH2CH2CO2R29, -CONR30SO2R31, -SO2Z, o un par adyacente de R2, R3 y R4 que al ser tomados juntos forman un anillo carbocíclico o heterocíclico fundido de 5 o 6 miembros; R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30 y R31 son independientemente seleccionados de hidrógeno, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, haloalquinilo, arilo opcionalmente sustituido y arilalquilo opcionalmente sustituido; y Z es halógeno.
Patent EC-SP951520-A (EC)
Title: Heterociclil- benzoilguanidinas, procedimiento para su preparacion y preparaciones farmaceuticas que las contienen
Inventor: DORSCH DIETER
IPC: C07D233/60
Filed: 1995-08-26
Abstract: Heterociclil - benzoilguanidinas de la fórmula I en la cual R1, R2, R3 y Het tienen los significados dados, así como sus sales fisiológicamente inobjetables, muestran propiedades anti-arrítmicas y actúan como inhibidores de los antiportadores Na+/H+.
Patent EC-SP961736-A (EC)
Title: Metodo de tratamiento
Inventor: BAX RICHARD PEREGRINE
IPC: A61K9/107
Filed: 1996-04-30
Abstract: Se proporcionan formulaciones pediátricas en forma de suspensión líquida acuosa que contienen amoxicilina trihidrato y clavulanato potásico en una proporción desde 6:1 hasta 8:1 para su utilización en un régimen de dosificación BID para el tratamiento de infecciones bacterianas.
Patent FI-20022003-A (FI)
Inventor: SUOVANIEMI OSMO
IPC: B01L3/02
Filed: 2002-11-08
Abstract: A multichannel pipette, the suction tube arrangement of which is arranged to be resilient, so that a disposable tip is attached similarly to each suction tube regardless of the shape and elastic characteristics of a tip rack. The pipette comprises a body and a plunger-cylinder system with suction tubes for each channel. Each suction tube is thus adapted to the body, that the suction tube is movable between two extreme positions in its vertical direction with respect to the body.
Patent GB-1052677-A (GB)
IPC: B65F1/06
Abstract: 1,052,677. Refuse bins. A. E. ARTHUR Ltd. March 18, 1964, No. 11420/64. Heading A4A. A refuse bin, particularly for kitchen garbage, comprises a container 2 having at its rear edge an anchorage member 14 with ends 14a for engagement with the rear edge of an opened-out disposable bag the front edge of which is folded over the front edge of the container and clamped by the walls 12, 13 (Fig. 5, not shown) of a U-section clamping strip which also forms a handle 8. The bag is preferably of polyethylene and the container may have a lid and be wall &c. mounted or may be supported in a casing as disclosed in Specification 1,052,678. A buffer strip 10, cushioning closure of the container into the casing, is clamped between walls of the handle.
Patent GB-1053747-A (GB)
Abstract: 1,053,747. Shaping resin-impregnated tubing. ELECTRIC STORAGE BATTERY CO. March 25, 1964 [March 26, 1963], No. 12708/64. Heading B5A. [Also in Divisions D1 and F2] A thermosetting resin-impregnated fabric tube, particularly intended, when shaped, for retaining active material in leadacid storage batteries, is drawn over a stationary mandrel 14, having portions 18, 19, 21, Fig. 2, of reduced cross-section, and is shaped to the desired cross-section by a sizing portion 25, the tube being heated at portions 18, 19 and 21 by heaters 37-39, Fig. 1, and by heaters 41 during passage over portion 25, to progressively heat and finally cure the resin. The tube fabric may be woven, braided or knitted from glass or synthetic resin fibres and an example of an impregnating resin is phenolformaldehyde resin. Tubing from a roll 1 is passed through uncured resin 5, past wipers 8 which remove excess resin and through pressure rollers 9 to work the resin into the fabric. Roller 15 draws the tube on to mandrel 14, which is protectively coated, e.g. with a ceramic material or synthetic plastic material such as P.T.F.E., and rollers 26-29, 31, 32 at portions 22-24, Fig. 2, continue the drawing action, although at a slightly slower rate than roller 15, so that bunching of the tube occurs at the crooked part 13 of the mandrel. Portions 22- 24 have a square cross-section although this is not necessarily the case for sizing portion 25. Further rollers 33-36 adjacent portion 25 are driven slightly faster than rollers 26-29, 31 and 32 so that the tube conforms exactly to the cross-section of the sizing portion. The heaters 37-39 and 41 may be infra-red lamps or hot-air blowers. Thereafter the tube is cooled by air from a blower 43 and cut into lengths by knives 45, 46. To reduce the drag on the tubing and also wear of the mandrel coating the cross-section of sizing portion 25 may be modified to reduce the area of contact, Fig. 6 (not shown).
Patent GB-1054326-A (GB)
IPC: A61B5/023
Abstract: 1,054,326. Sphygmomanometer. P. P. PARERA and D. F. LLAURADO. Sept. 20, 1963 [Sept. 24, 1962], No. 37135/63. Heading A5K. A sphygmomanometer comprises a manometer tube 15 rising from mercury receptacle 16 and leading to compression chamber 18, the compression chamber 18 enclosing the tube 15 the internal diameter of the tube 15 decreasing from the receptacle 16 to the compression chamber 18 as to tend to compensate in operation for any departure from a fixed proportion between the height of mercury and the applied input pressure. Filters 17, 22 and 24 allow air to pass but not mercury. In use, the inlet 21 is connected to an armlet and while no pressure is applied the compression chamber 18 and the atmosphere are in communication via tube 15 and filters 17 and 24. On application of pressure the mercury in receptacle 16 is forced upwards cutting of the air passage between the compression chamber and the atmosphere and the pressure applied may be read from a scale. A cylindrical lens or prism 19 is placed in front of or in the compression chamber to facilitate reading of the scale.
Patent GB-1226407-A (GB)
IPC: C08J9/04
Filed: 1967-06-15
Abstract: 1,226,407. Laminates. IMPERIAL CHEMICAL INDUSTRIES Ltd. 12 June, 1968 [15 June, 1967], No. 25158/68. Divided out of 1,208,283. Heading B5N. [Also in Divisions B2, C2 and C3] Laminates comprise a sandwich between two sheets of asbestos, paper, cardboard, hardboard, plasterboard, metal or a synthetic resin, of a foamed resin of a phenolic resole derived from a mixture of phenolic compounds which contains a polynuclear diphenol of formula where # is a phenylene group which may be substituted by alkyl, alkoxy or hydroxyl groups at least one hydrogen atom being ortho or para to a hydroxyl group and #<SP>1</SP> is a phenylene group which may be substituted by alkyl or alkoxy groups or halogen atoms, the diphenol forming from 1/11th to 1/3rd of the total molar concentration of the mixture. The phenolic mixture may comprise phenol and
Patent GB-1228330-A (GB)
IPC: F26B5/06
Filed: 1969-11-18
Abstract: 1,228,330. Freeze drying. M. L. BREWSTER. 18 Nov., 1969, No. 56348/69. Heading F4G. The subject matter disclosed is contained in Specification 1,170,872, but the claims relate to a vacuum chamber having two parallel plates dividing an enclosure into a central chamber and two side chambers, wherein there are valves to prevent or permit communication between the central chamber and each of the side chambers, condensers are provided in each side chamber and means are provided to selectively create a vacuum in any of the chambers.
Patent GB-1228355-A (GB)
IPC: B60B3/06
Filed: 1967-05-02
Abstract: 1,228,355. Vehicle wheels. GEORGE BLAIR & CO. Ltd. 2 May, 1968 [2 May, 1967], No. 20380/67. Heading B7C. [Also in Division B3] A ferrous metal wheel disc has a peripheral formation consisting of a number of lugs 7 each having one bolt hole, the lugs being situated on the exterior of a T- or L-section annular ring 5 which has a web extending in a plane transverse to the axis of the disc, there being on at least one side of the web radial ribs 9, 10 thickened as at 11 and/or 14. The disc is made by casting (see Division B3).
Patent GB-1228615-A (GB)
IPC: C07D333/38
Filed: 1968-07-26
Abstract: 1,228,615. Benzofuran carboxylic acids. J. R. GEIGY A.G. 26 July, 1968 [28 July, 1967], No. 35699/68. Heading C2C. Novel compounds of the general Formula (I) wherein Q represents a chlorine or bromine atom, R represents hydrogen or C 1-4  alkyl group, Y represents hydrogen or the methyl group and Z 1  as well as Z 2  independently represent hydrogen, a C 1-4  alkyl group or alkoxy group or a fluorine chlorine or bromine atom, as well as their salts with inorganic or organic bases are obtained (a) by reacting according to Friedel-Crafts, a compound of the general Formula III with a carboxylic acid chloride of the general Formula IX or (b) by adding halogen to a compound of the general Formula II and, if desired, converting the reaction product into a salt with an inorganic or organic base. Therapeutic preparations containing the compounds of Formula I and having diuretic and saluretic activity are administered orally.
Patent GB-1229545-A (GB)
IPC: B26B21/26
Filed: 1969-07-07
Abstract: 1,229,545. Razors. WARNER-LAMBERT PHARMACEUTICAL CO. 7 July, 1969 [25 Oct., 1968], No. 34119/69. Heading B4B. A magazine for a safety razor comprises a ribbon-type blade 18 connected between a supply reel 16 and a take-up reel 17 and having a portion 19 located on a support 22 provided between front and rear wall portions 34, 20. The supply and take-up reels 16, 17 are located in housings 39, 42, respectively, formed on the rear wall 20 of the magazine, the take-up reel being provided with a ratchet device 17 which is actuated by means of a lever 26 in order to move a fresh cutting portion of the blade on to the support 22. Gears 27, 28 are mounted on the reels 16, 17 so as to rotate therewith, the gear 27 being provided with numbers in order to indicate the number of unused blade edges left in the magazine, the numbers being visible via an opening 104 formed in the front wall 34. In order to provide a tension on the blade during the take-up movement, the inside distance between the front and rear walls is made less than the axial distance between the end faces of the supply reel 16 thereby producing a resistance to the rotation of the latter. A blade guard 13 is pivoted in holders 57, 58 formed on the rear wall 20 and is provided with a lever 65 adapted to be engaged by a cam surface 71 formed on a ring 29 which is rotatable about the housing 39. The ring is actuated by a lever 72 in order to vary the angular position of the guard and so alter the angle of cut; graduations (73, Fig. 6) are provided on the front wall 34 in order to indicate the setting of the guard. Openings 80, Fig. 2, are formed in the rear wall 20 in order to allow rinsing liquid to flow over the blades; openings 49 are also provided in a magazine holder 12 and a trough 51 is formed on the front wall 34 in order to direct the liquid through the openings. In a modification instead of the blade being coiled in the reel 16, the latter may be dispensed with and the coil of blade held in the housing 39. The various parts of the magazine are made from a plastics material.
Patent GB-1232203-A (GB)
IPC: E06B3/20
Filed: 1967-11-06
Abstract: 1,232,203. Moulding frames. G. K. FINDLAY. 23 Oct., 1968 [6 Nov., 1967], No. 50245/67. Heading B5A. [Also in Division E1] Square or rectangular frame members, e.g. for windows, are produced by moulding a mixture of synthetic resin and wood chips between a vertical core of square or rectangular shape, and four inwardly displaceable compressing mould components each positioned opposite a different core surface. After collapsing the core inwardly and withdrawing the mould components, the hollow tube produced is vertically removed and cut transversely into frame sections, to which a coating of synthetic plastics may be applied i.e. by spraying and hardening by passage through electron beams. The frame members may be moulded with projections or recesses e.g. for hinge components and fastenings.
Patent GB-1239058-A (GB)
IPC: B01D46/02
Filed: 1968-07-29
Abstract: 1,239,058. Filtering gases. J. PAUSCH. 29 July, 1968 [3 Aug., 1967], No. 36002/68. Heading B1T. Reverse-flow cleaning of an inward-flow tubular dust filter element 26 is achieved by a gas jet 54 which passes at high pressure into the bowl-shaped opening 44 of a tube 48, thus entraining extra cleaning gas present in chamber 18 to increase further the volume of reverse flow. As described, the dispersion cone of gas from tube 48 comprises a zone B of high pressure; this creates a surrounding zone C of lower pressure, whose effect is to suck in still more gas from chamber 18 via auxiliary channels 52. Chamber 18 is divided by plate 14 from a chamber (16) (Fig. 3, not shown) which encloses a plurality of such filter elements 26 arranged for parallel flow. Each element comprises a fabric sock 28 secured by a band 38 and supported by a wire coil 30 which screws into a thread 40. The dust-laden air inlet to chamber (16) comprises a bent tube (20) directed towards a normally closed opening (22) in a dustcollecting hopper at the bottom of the chamber. A preliminary separation is effected therein.
Patent GB-1251081-A (GB)
IPC: B60R25/04
Filed: 1968-03-19
Abstract: 1,251,081. Locks. U.M. ELECTRICAL DISTRIBUTORS Ltd. 18 March, 1969 [19 March, 1968], No. 13272/68. Heading E2A. [Also in Divisions F1 and G4]  A control system for activating electrical apparatus comprises a plurality of bistable circuits P..T, brought into a predetermined state by sequentially applied pulses, the electrical apparatus (e.g. solenoid W) being activated only if the bistable circuits are brought into and out of said predetermined state in a predetermined sequence and arranged such that if pulses are applied in other than said predetermined sequence all the bistable circuits are brought into the other state.  As shown in Fig. 1, the left hand transistor Tl of the first bistable circuit P and the right hand transistors of the other bistable circuits Q..T are connected to the power supply via a delay circuit R4, C2 so that when the supply is first connected, the left hand transistor T1 of the first bistable circuit P is conductive whilst the corresponding transistors in the remaining bistable circuits Q...T are non- conductive. In order to actuate the controlled device, the switch SW is set to the first digit of a pre-arranged code and button V depressed so that a positive pulse is fed to terminal A. This action turns off T2, turning on T1 and turns on T3, turning off T4. This action is then repeated by setting switch SW to the remaining digits of the code until T11 is turned on, energizing a thyristor (not shown) or relay W which completes the ignition circuit in a vehicle. Alternatively, the relay W may release a solenoid lock on the rear door of a lorry or actuate a solenoid fuel valve. Operation of switch SW in the incorrect order or the initiation of a second pulse at any one setting will set all the bistable stages at P..T to an OFF condition. Components R3, C3 prevent the effect of contact bounce. In Fig. 2 (not shown) the switch SW carries 24 letters of the alphabet and is coupled to the rest of the circuit via a multi-way socket into which a corresponding plug may be inserted, the particular code being determined by the connections within the multi-way plug.
Patent GB-1256518-A (GB)
IPC: H01L21/607
Filed: 1968-11-30
Abstract: 1,256,518. Welding by pressure. NATIONAL RESEARCH DEVELOPMENT CORP. 20 Nov., 1969 [30. Nov., 1968], No. 56981/68. Heading B3R. [Also in Division H1] A semi-conductor device is mounted on a copper heat sink by coating the contact surface of the device with silver or gold, coating the corresponding surface of the heat sink with silver or gold and bonding -the device to the heat sink by thermocompression. In an embodiment a silicon semi-conductor device is mounted by evaporating a flash of titanium on to the device, coating the device and the sink with gold and bonding the two parts together by thermocompression bonding at 150‹ C. and a pressure of 5.10<SP>4</SP> p.s.i. Ge and GaAs devices may also be mounted. In an alternative embodiment an oxidized silicon surface may be bonded.
Patent GB-1258464-A (GB)
IPC: H04R1/08
Filed: 1969-08-18
Abstract: 1,258,464. Microphones. OLYMPIA WERKE A.G. 18 Aug., 1969 [17 Aug., 1968], No. 41116/69. Heading H4J. A hand microphone has sound inlets 2, 3, 4 so arranged relative to the diaphragm 13 of the microphone capsule that sound waves only impinge obliquely on the diaphragm 13, preferably at an angle between 0 and 60 degrees. Direct sound pressure is thereby prevented from blasting the microphone. The diaphragm 13 has a flat front face. A switch for use with a dictation machine is provided.
Patent GB-1258508-A (GB)
IPC: F16K31/12
Filed: 1969-04-15
Abstract: 1,258,508. Valves; hydrostatic transmission control. EMERSON ELECTRIC CO. 15 April, 1969 [10 May, 1968], No. 15455/71. Divided out of 1,258,507. Headings F2D and F2V. A pressure responsive valve assembly for unitary installation and removal from a valve body 43 forming part of the control valve of the main application comprises a spring- biased valve element 54 axially slidable in a cylinder 47 having a removable valve seat 50. The end wall of the cylinder has a flange 48 which is drilled to receive studs 45 which secured the valve assembly to the valve body 43. The end wall has a port 62 through which control pressure is applied. Removal of the valve assemblies from the body may be facilitated by providing drilled holes in the flange 48 to receive jacking screws.
Patent GB-1265018-A (GB)
IPC: H01L29/00
Filed: 1969-08-11
Abstract: 1,265,018. Semi-conductor devices. MATSUSHITA ELECTRONICS CORP. 11 Aug., 1969 [27 Aug., 1968], No. 40024/69. Heading H1K. A pressure-sensitive Schottky barrier device comprises a body of semi-conductor material having a recess, an insulating layer overhanging the edge of the recess, a metal layer covering the recess and the surrounding insulating layer so that it forms a Schottky barrier with the semi-conductor material within the recess surrounded by a space, and means for applying pressure to the metal layer. The space prevents the formation of an inversion layer due to the insulating layer and this reduces the reverse leakage current and increases the breakdown voltage. As shown, Fig. 3, an N-type layer 32 is epitaxially grown on a lower resistivity Si substrate 31, a layer of silicon oxide or nitride is formed on the surface and a window 36 is opened using a photoetching technique. A recess 41 is then chemically etched in the layer 32 the edge of the insulating layer being undercut. A layer 37 of Mo or W is then sputtered on to the wafer to form a Schottky barrier in the recess surrounded by an annular space 38. The layer 37 is protected by a Au layer 39 and an ohmic contact is provided on the lower face of the substrate 31 by depositing a layer 42 of Au 3% Sb and a lead-out metal layer 43. Pressure is applied to the Schottky barrier contact 37 by means of a W wire 40 which also forms the output lead.