Patent AU-2012318303-B2 (AU)
Title: Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of Factor VIII
Inventor: ZOLLNER SABINE
IPC: A61K38/00
Filed: 2012-10-18
Granted: 2015-09-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) I CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/057171 A9 25 April 2013 (25.04.2013) W I PO I P CT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 38/36 (2006.01) A61K 47/42 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A61K 38/37 (2006.01) A 61P 7/04 (2006.0 1) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, A61K 47/36 (2006.01) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (21) InternatIonal Application Number: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, PCT/EP2012/070620 NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (22) International Filing Date: RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, 18 October 2012 (18.10.2012) TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 11185650.6 18 October 2011 (18.10.2011) EP UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 61/548,612 18 October 2011 (18.10.2011) Us TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant (for all designated States except US): CSL MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, BEARING GMBH [DE/DE]; Emil-von-Behring-Strae TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 76, 35041 Marburg (DE). ML, MR, NE, SN, TD, TG). (72) Inventors; and Published: (71) Applicants (for US only): ZOLLNER, Sabine [DE/CH]; - with international search report (Art. 21(3)) Thunstrasse 70, CH-3074 Muri (CH). METZNER, Hubert [DE/DE]; Im Boden 6, 35041 Marburg (DE). - with sequence listing part of description (Rule 5.2(a)) (74) Agents: HAUSER, Hans-Peter et al.; CSL Behring (48) Date of publication of this corrected version: GmbH, Emil-von-Behring-StraBe 76, 35041 Marburg 3 April 2014 (DE). (15) Information about Correction: (81) Designated States (unless otherwise indicated, for every see Notice of 3 April 2014 kind of national protection available): AE, AG, AL, AM, (54) Title: COMBINED USE OF A SULFATED GLYCOSAMINOGLYCAN AND A HYALURONIDASE FOR IMPROVING THE BIOAVAILABILITY OF FACTOR VIII (57) Abstract: The present invention relates to pharmaceutical preparations comprising Factor VIII, a sulfated glycosaminoglycan N and a hyaluronidase for the non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders. The in vention further relates to the combined use of a Factor VIII, a sulfated glycosaminoglycan and a hyaluronidase for the treatment and prevention of bleeding disorders, and to a method for increasing the bioavailability afier non- intravenous administration of Factor VIII by co-adminstration of a sulfated glycosaminoglycan and a hyaluronidase.