baber/WOPTO huggingface dataset:
Patent RO-116897-B1 (RO)
Title: Biphenyl-2-carboxylic acid tetrahydroisoquinolin-6-yl amide derivatives, intermediates used in their synthesis, pharmaceutical composition containing the same and method of treatment
Inventor: CHANG GEORGE
IPC: A61P5/00
Filed: 1996-06-07
Abstract: The invention relates to byphenyl-2-carboxylic acid tetrahydroisoquinolin-6-yl amide derivatives, to intermediates in their synthesis, to pharmaceutical composition containing the same and to a method of treatment. According to the invention the compounds are defining by the general structural formula (I) wherein x, y, z have well-defined significations. According to the invention, the composition comprises a therapeutic efficient quantity of a compound having the formula (I) or a pharmaceutically acceptable salt and pharmaceutically acceptable carrier and eventually a supplementary lipid reducing agent. Method of treatment of the diseases selected from atherosclerosis, pancreatitis, obesity, hypercholesterolemia, hyperlipidemia and diabetes that comprises the administration in a patient needing such a treatment of a therapeutic efficient quantity of a compound with formula (I).
Patent RO-118426-B1 (RO)
Title: Indole derivatives used for treating diabetes mellitus and obesity
Inventor: KATO SHIRO
IPC: C07D209/30
Filed: 1995-11-27
Abstract: The invention relates to indole derivatives used for treating diabetes mellitus and obesity, to processes for preparing the same, to a pharmaceutical composition containing them and to the utilization thereof in the therapy. According to the invention, the derivatives have the general formula I, wherein R1 is a lower alkoxy group, a lower alkoxycarbonyl-lower alkoxy group, a carboxy-lower alkoxy group, a lower alkoxycarbonyl group, a phenyl-lower alkoxy group optionally hydroxylated with lower alkyl, di-lower alkylaminosulphonyl group, etc ; R2 represents hydrogen, halogen, a lower alkoxy group, lower alkoxycarbonyl-lower alkoxy group, carboxy-lower alkoxy group, etc; R3 represents hydrogen or lower alkyl; R4 represents halogen or trifluoromethyl; and R5 represents a lower alkyl group. The compound is a potent adrenergic receptor-stimulating agent with excellent selectivity and useful in the prophylaxis or treatment of obesity or diabetes mellitus.
Patent RO-120318-B1 (RO)
Title: Powder composition for cosmetic and therapeutical applications
Inventor: TIMBUS IOAN VICTOR
IPC: A61K33/08
Filed: 1999-02-09
Abstract: The invention relates to a clay-based powder composition with cosmetic and therapeutical applicability.
Patent WO-02053314-B1 (WO)
Title: Procede et appareil de moulage par centrifugation
Inventor: NOBLE CHARLES
IPC: B22D13/10
Filed: 2002-01-03
Abstract: L'invention porte sur un procédé et un appareil destiné à être utilisé dans le moulage par centrifugation d'articles métalliques et permettant de former un revêtement compact (204) d'un matériau réfractaire particulaire sur une surface interne (22) du moule. Une quantité de matériau réfractaire particulaire, sans liant, sec est déposée sur la surface interne (22) du corps (12) du moule rotatif de façon à former une couche densifiée par centrifugation. Un outil de raclage (16) est mis en contact avec une couche de matériau réfractaire alors que le corps du moule continu de tourner de façon à racler et compacter la couche de particules. Cet outil (16) est orienté au niveau d'un angle par rapport au sens de déplacement de la couche de particules de façon à pénétrer dans la couche et rendre les particules compactes vers la surface interne du corps du moule. La combinaison de la force centrifuge et du compactage mécanique  des particules permet de former un revêtement (204) interne compact, imperméable à l'air, dense, dont les particules sont enchevêtrées, les vides entre les particules n'étant pas interconnectés à un vide adjacent. Le moule est constitué d'au moins un orifice d'évacuation d'air communiquant avec une surface interne. Un revêtement poreux est formé sur la surface interne du moule de façon à communiquer avec l'orifice d'admission et l'orifice d'évacuation de l'air.
Patent WO-02095355-B1 (WO)
Title: Procede electrochimique pour criblage a haut rendement de tres faibles quantites de composes candidats
Inventor: HELLER ADAM
IPC: G01N27/403
Filed: 2002-05-17
Abstract: L'invention concerne un procédé électrochimique permettant de doser successivement l'efficacité de chaque composé candidat appartenant à une pluralité de composés candidats, par le biais de la détermination du degré auquel chaque composé conditionne directement ou indirectement la vitesse de réaction électrochimique catalysée par une molécule cible. Ledit procédé consiste à introduire successivement des échantillons contenant des composés candidats dans la chambre de détection d'une cuve à circulation conçue pour contenir jusqu'à 100 microlitres de liquide, mesurer la vitesse de la réaction électrochimique catalysée par une molécule cible, rincer la cuve à circulation avec un vecteur après chaque mesure, et déterminer l'efficacité de chaque composé candidat en fonction de la vitesse mesurée de la réaction électrochimique catalysée par une molécule cible. Le procédé est utile pour détecter de très petites quantités d'agents actifs potentiels, de l'ordre de 0,1 pg. Idéalement, un médiateur d'oxyde de réduction non lixiviable est disposé sur l'électrode de travail de sorte à faciliter le transfert des électrons entre la molécule cible et la surface de l'électrode de travail. Ledit procédé peut être employé pour évaluer la capacité des composés candidats en tant qu'inhibiteurs d'enzyme ou que ligands, par exemple, en tant que ligands de liaison de récepteur.
Patent WO-03069079-B1 (WO)
Inventor: HALLORAN DANIEL N
IPC: E03D1/30
Filed: 2003-02-11
Abstract: A flush valve (20) is connectable to a blind hole (15) in a vertical wall (14) of a toilet tank (11). An overflow member (21) is in fluid communication with a flush valve housing (26). The flush valve housing (26) is wider than it is higher, and fits into a blind hole (15) in the tank wall (14) of similar cross sectional shape. The tank (11) is formed with an attachment ear (47). A clip (39) mounted on the housing (26) holds the housing (26) against the tank wall (14), while the non-circular nature of the housing (26) and blind hold (15) prevent relative rotation there between.
Patent BG-62424-B1 (BG)
Title: Method and device for monitoring the behaviour of a tv visual audience
Inventor: JANOV MIKHAIL A
IPC: H04N7/173
Filed: 1997-01-10
Abstract: The method is effected when at a given moment a singal istaken from the subscriber's house of the chosen TV channel, it isprocessed and analyzed by a videoprocessor. The informationproduced in this way for the positioning of the service codes inthe videosignal transmitted by the TV head office enters amicroprocessor. It adds additional service information which ismixed with high frequency alternating in a stepping manner with aninterval across a TV channel. When the frequency matches that ofthe the watched TV channel the service information is mixed withthe TV signal at the aerial. In this way the signal at the videooutput of the TV set also contains the serivce information whichis analyzed by the videoprocessor and is read by themicroprocessor. The method is effected by a unit consisting of amicroprocessor (MPU) connected to memory (RAM + EPROM), with modem(MODEM), real time clock (RTC), display (INDICATION) and remotecontrol unit (BD), on one side, and on the other - to the TVprocessing of a complex TV signal (TVSP), to frequency synthetizer(SYNT) connected to a voltage controlled generator (VCO) and themixing unit (MIX), the (TVSP) being also connected to therecording output (VIDEO).5 claims, 1 figure
Patent BG-64007-B1 (BG)
Title: Method for the preparation of sertindol
Inventor: BECH SOMMER MICHAEL
IPC: C07D401/04
Filed: 1999-11-04
Abstract: By the method N-(4-fluorphenyl)-N-(2-carboxy-4-chlorphenyl)glycine is produced by a reaction between a salt of an alkaliine metal of 2,5-dichlorobenzoic acid and a salt of an alkaline metal of N-(4-fluorphenyl)glycine in aqueous alkaline medium in the presence of a copper catalyst. There follows cyclization of glycine to the respective 3-acetoxyindole; reduction of 3-acetoxy-indole and subsequent elimination of H2O, and this forming 5-chloro-1-(4-fluorphenyl which reacts with 4-piperidon in a mixture of acetic acid and concentrated HCl. The 5-chloro-1-(4-fluorphenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indol e produced is reduced and this compound reacts with 1-(2-chlorethyl)-2-imidazolydinol until sertindol is produced. Alternatively, 5-chloro-1-(4-fluorphenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indol e first reacts with 1-(2-chlorethyl)-2-imidazolydinol,there following reduction of the sertindol thus produced. This method uses reagents and solvents which are suitable and enable large-scale production, the general yields being improved. 29 claims
Patent BG-66276-B1 (BG)
Title: A process for the preparation of iopamidol and the new intermediates therein
Inventor: ANELLI PIER
IPC: A61K49/04
Filed: 2003-05-19
Abstract: A process for the preparation of (S)-N,N'-bis[2-hydroxy-1-hydroxymethyl)ethyl]-5-](2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iopamidil) starting from 5-amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]2,4,6,-triiodo-1,3- benzenedicarboxamide, which process comprises a) reacting the compound of the formula quoted above, with a suitable protecting agent, to give a compoundof formula wherein R is a group of formula wherein R1 is a hydrogen atom, a C1-C4 straight or branched alkoxy group, R2 is hydrogen, a C1-C4 straight or branched alkoxy group and R3 is a C1-C4 straight or branched alkyl group, a trifluoromethyl of a trichlormethyl group b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula wherein R is as defined above and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formulae A. The invention also refers to the new intermediates of formulae (III) and (IV) wherein -R is a group A. 18 claims
Patent BG-67432-B1 (BG)
Title: Product containing lyophilized snail proteins
Inventor: LOZANOV VALENTIN
IPC: A61K38/17
Filed: 2019-02-26
Abstract: The present invention relates to a product which will find application as a kind of food intended for people who cannot digest the conventional one, as well as a food supplement. According to the invention, the product contains /in wt. %/ lyophilized protein in an amount of 23-33, as the lyophilized protein is a mixture of lyophilized snail meat and lyophilized enzyme hydrolyzate from snail meat in a ratio of 5 : 1, and the remaining components are in the following amounts of dextrose from 45 to 55 or fructose from 45-55, maltodextrin 10-25, sodium citrate 0.5 and flavour 3.5 to 4.5. According to the invention, the product provides the following advantages: it does not burden the liver and is easily absorbed by the body; the biological activity of the substances is maintained for a long period of time; the enzymes contained therein retain their conformational integrity and activity; the shelf life and storage are significantly extended, without requiring special conditions for storage and transportation; no preservatives or other excipients are needed; it also provides an opportunity to prepare solutions of the product according to the concentration required by the user.
Patent CH-716811-B1 (CH)
Title: Nähmaschine und Verfahren zum Ermitteln der Materialdicke eines Flächengebildes.
Inventor: GUNNAR SCHLAICH
IPC: G01B11/06
Filed: 2019-11-18
Abstract: Die Nähmaschine (1) umfasst eine Projektionsvorrichtung (21), die dazu ausgebildet ist, in mindestens zwei unterschiedlichen Abstrahlrichtungen (C, C') ein Lichtmuster auf das Flächengebilde (15) zu projizieren. Diese Lichtmuster werden auf den Bildsensor (33) einer Kamera (31) abgebildet. Aus den Positionen der abgebildeten Lichtmuster berechnet die Steuerung der Nähmaschine (1) die Dicke (D) des jeweiligen Flächengebildes (15).
Patent EP-1005956-B1 (EP)
Inventor: STOCKER MARK ANDREW
IPC: B24B47/12
Filed: 1997-06-11
Granted: 2003-07-30
Abstract: A method of grinding the edge of a disc (36) uses a grinding machine having mounted thereon a grooved grinding wheel (32), in which the groove is formed in situ using a forming wheel (56,58) also mounted on the grinding machine. After a workpiece (36) has been ground or after a succession of workpieces (36) have been ground, re-engaging the grinding wheel (32) and the forming wheel (56,58) with the grinding wheel (32) remaining in situ, to re-form the groove (34) in the grinding wheel (32) to correct for wear. A grinding machine comprises a grinding wheel (32), drive means therefor, a workhead and workpiece spindle and drive means (38,40) therefor, a forming wheel (56,58) and drive means (28) therefor, means for moving the grinding wheel (32) so as to plunge grind the edge of the grinding wheel (32) to form a groove (34) therein of precise cross-section and means for effecting relative movement between the grinding wheel (32) and the forming wheel (56,58) to enable the grinding wheel (32) to engage with the edge of a circular workpiece (36) component mounted on the workpiece spindle (28,30) to edge grind the component and wherein the forming wheel (56,58) is also mounted on the workpiece spindle (28,30) for rotation therewith, and the grinding wheel (32) is a resin bonded wheel.
Patent EP-1061779-B1 (EP)
Inventor: KRUMMEL PETER
IPC: H05B41/24
Filed: 2000-03-09
Granted: 2006-05-24
Abstract: The fluorescent lamp operating method has an integrated control and regulation circuit (IC) used for regulating the load current in a half bridge load circuit (4) containing at least one fluorescent lamp (FL), with a timing device (PST, IT) providing a sequence of selection signals (S1,S2,S3,S4) upon starting, used for activating different reference levels for a load current monitoring circuit (MON), providing a control pulse (QM) upon reaching each reference level, with automatic disconnection upon detection of an operating fault. An internally generated DC signal is superimposed on the load current signal fed to the monitoring circuit during each lamp ignition period, dependent on the lamp characteristics, for matching the fixed reference level independent of the type of lamp used. An Independent claim for an electronic bias device for operation of a fluorescent lamp is also included.
Patent EP-1083360-B1 (EP)
Inventor: PETERS MARTIN
IPC: B60T17/22
Filed: 2000-09-06
Granted: 2006-10-18
Abstract: The arrangement has at least one wheel sensor (13) for determining the instantaneous angle setting or angular speed of the wheel, at least one weight sensor (12) for determining the weight of the vehicle loading, an actuator state sensor, a processor (15) for processing the sensor signals and a time base signal and a display unit (17,18). The processor determines a value for the change in the temperature of the first or second brake element (2,3) for at least one time point relative to a preceding time by determining the energy fed to the first or second brake element in comparison with at least one stored value for the kinetic energy of the vehicle at the preceding time. Independent claims are also included for a method of determining the temperature of a vehicle brake element and for a vehicle with an arrangement for determining the temperature of a brake element.
Patent EP-1106452-B1 (EP)
Inventor: LANDMANN ALFRED
IPC: B60R25/20
Filed: 2000-09-18
Granted: 2005-11-16
Abstract: The steering lock includes an electromagnet (6) in the stator (1) which is co-axial with the rotor (4). The rotor has a stop which acts with another stop on the stator when the rotor is turned back to its initial position before the initial position is reached. The rotor can be shifted axially in the stator by the electromagnet against the spring load force.
Patent EP-1070507-B1 (EP)
Inventor: COX JAMES P
IPC: C05G5/00
Filed: 1993-05-14
Granted: 2003-08-20
Abstract: Methods and compositions comprising polyfunctional biowaste treatment complexes for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. Reduction of the biowaste volume, potentiation of the recovery of materials of value from the biowaste and other advantages may also be obtained by use of appropriate consitituents in the complex.
Patent EP-1154221-B1 (EP)
Inventor: GERBER PETER
IPC: F41G3/26
Filed: 2000-12-30
Granted: 2007-04-25
Abstract: The simulation system has an interrogation device (1) providing a coded laser or electromagnetic beam, used for identification of a responder device, provided with sensors for detection of the coded beam, for supplying corresponding electrical signals to a central unit, with transmission of a response impulse back to the interrogation device. The response impulse is received by a central unit (15) at the interrogation device, for calculating the range between the interrogation device and the responder device, for selection of the correct munition. An Independent claim for a method for simulating firing of a weapon is also included.
Patent EP-1166649-B1 (EP)
Inventor: KOYAZOUNDA ANTOINE
IPC: A23L19/10
Filed: 2000-06-21
Granted: 2007-06-06
Abstract: Food product comprises traditionally produced manioc (70-80%) together with vegetables or fruit (20-50%).
Patent EP-1205103-B1 (EP)
Inventor: PICCARI RICCI PIER PAOLO
IPC: A01G7/06
Filed: 2000-11-08
Granted: 2007-08-15
Abstract: A device for arboreal plant endotherapy comprises: a hollow cylinder (1) provided with a piston (2), means (3) for actuating the motion of the piston (2), at least an injection needle (41, 42, 43, 44) and means (4) for connecting the needle (41, 42, 43, 44) to the cylinder (1), to inject into the trunk of a plant at least a dose of a phytotherapeutic formulation loaded into the cylinder (1). A central processing unit (CPU) automatically and intelligently controls the device, implementing a program which comprises a procedure for determining the dose (VDOS) of formulation to be administered to a plant and a procedure to control the means (3) for actuating the motion of the piston (2) according to the dose (VDOS) to be administered. A keyboard (TT) is connected to the central unit (CPU) to enter data manually and to manage the commands of the device. An analogue digital converter (A/D), connected to the central unit (CPU) and coupled to an input interface (II), receives signals coming from a displacement sensor (5) for the detection of the position of the piston (2) in the cylinder (1). The central processing unit (CPU) controls the means (3) for actuating the motion of the piston (2) through an output interface (IU) connected thereto. <IMAGE>
Patent EP-1150869-B1 (EP)
Inventor: VAN DEN BERG RONALD PETER
IPC: B60R21/268
Filed: 2000-02-16
Granted: 2003-10-08
Abstract: The invention relates to a controllable gas generator, more particularly for an airbag, based on a combination of a first gas generating system with compressed gas and a second gas generating system with a solid material which generates gas upon combustion, wherein the amounts of gas generated by the two systems are controllable dependently on and independently of each other.
Patent EP-1171203-B1 (EP)
Inventor: THYES MARCO
IPC: A61P9/02
Filed: 2000-03-06
Granted: 2004-06-02
Abstract: Drugs comprising modification D of doxazosin mesylate are described. They are suitable for treating high blood pressure.
Patent EP-1161587-B1 (EP)
Inventor: EDWARDS DAVID BRIAN
IPC: B65D65/46
Filed: 2000-03-07
Granted: 2003-01-29
Abstract: A process for producing a thermoformed package comprises the steps of placing a first sheet of film over a forming die having at least one cavity, heating the film to mould the film into the at least one cavity thereby forming at least one recess in the film, placing a composition in the at least one formed recess, and sealing a second sheet of film across the at least one formed recess to produce at least one closed package. Each cavity is cooled to between 2 and 10 degrees C.
Patent EP-1169470-B1 (EP)
Inventor: BACHOVCHIN WILLIAM
IPC: C07K7/06
Filed: 2000-04-10
Granted: 2004-06-23
Abstract: The invention provides a method for determining a preferred amino acid sequence motif for an active site an associated substrate specificity subsites of an enzyme. In the method of the invention, an enzyme is contacted with an oriented degenerate peptide library, certain peptides within the library which are substrates for the enzyme are bound by the enzyme, and bound peptide/enzyme complexes are separated from unbound peptides. The bound peptides are released from the enzyme and are sequenced. A preferred amino acid sequence motif for the active site and associated specificity subsites is determined based upon the relative abundance of different amino acids residues at each degenerate position. The invention also provides peptides, peptide analogs, and other small molecules which have a variety of uses and can be derived from the present invention.
Patent EP-1285544-B1 (EP)
Inventor: NIEMELAE KARI
IPC: H04W88/08
Filed: 2000-04-20
Granted: 2005-11-09
Abstract: The invention relates to a base station sub-system in a mobile communication network, in particular a cellular mobile communication network, comprising a controller unit, where said controller unit is connected to a circuit switched network generating a plurality of circuit switched data frames, and where said controller unit is connected to a packet switched network generating a plurality of packet switched data frames. To enable a simultaneous circuit switched and packet switched communication over one dedicated channel between a base station sub-system and a mobile station is achieved in a way that a packet control unit comprises multiplexing/demultiplexing means, multiplexing/demultiplexing said circuit switched data frames and said packet switched data frames to/from a plurality of transmission data frames.
Patent EP-1182184-B1 (EP)
Inventor: SASAKI TORU
IPC: B01J27/055
Filed: 2000-05-02
Granted: 2007-04-18
Abstract: A process for efficiently producing highly pure tetrafluorobenzenemethanols, tetrafluorobenzenecarbaldehyde dialkyl acetals and tetrafluorobenzenecarbaldehydes, which are useful as, for example, intermediates in the production of cyclopropanecarboxylic acid esters having bactericidal effects, via a series of reactions starting with tetrafluorocyanobenzenes; and novel tetrafluorobenzenecarbaldehyde dimethyl acetal.
Patent EP-1101095-B1 (EP)
Inventor: VAN DEN BERG KAREL
IPC: G01N33/483
Filed: 2000-05-10
Granted: 2006-11-08
Abstract: A device which may be carried by and part of an unmanned vehicle which measures characteristics of manure of animals such as dairy cows that are milked and fed in a stable provided for them. The vehicle is supported by three driven wheels and carries a mechanism for analyzing manure which comprises a compression chamber for receiving a manure sample. A sieve is provided on one side of the chamber and a piston forces the manure sample through the sieve. By measuring the pressure required to squeeze the manure sample through the sieve, characteristics such as the fibrousness and the viscosity of the manure sample can be determined. The vehicle also carries an identification instrumentality for identifying the animal that provided the manure sample and may carry a temperature sensor and an inertia meter. It is operatively associated with a computer which registers data provided from analysis of each animal's manure sample and provides same as displayable data.