Patent SG-11201811719R-A (SG)
Title: Conjugates for targeted cell surface editing
Inventor: WOODS ELLIOT C
IPC: C07K14/47
Filed: 2017-06-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111111111111111111111111111111111111111111111111001111111111011110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/006034 Al 04 January 2018 (04.01.2018) WIP0 I PCT (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 39/00 (2006.01) CO7K 14/47 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (21) International Application Number: PCT/US2017/040411 HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: 30 June 2017 (30.06.2017) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/357,645 01 July 2016 (01.07.2016) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: THE BOARD OF TRUSTEES OF THE LE- EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, LAND STANFORD JUNIOR UNIVERSITY [US/US]; P.O. Box 20386, Office of the General Counsel, Build ing 170, 3rd Floor, Main Quad, Stanford, California MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 94305-2038 (US). (72) Inventor; and Published: (71) Applicant: GRAY, Melissa [US/US]; 10 Comstock Cir. — with international search report (Art. 21(3)) Apt. 328, Stanford, California 94305 (US). — with sequence listing part of description (Rule 5.2(a)) = (72) Inventors: WOODS, Elliot C.; 1210 Bellevue Ave., Apt. 406, Burlingame, California 94010 (US). XIAO, Han; = 2001 Manhattan Avenue, Apt. 314, East Palo Alto, Cal- _ - ifornia 94303 (US). BERTOZZI, Carolyn R.; Depart- - ment of Chemistry, Stanford University, Stanford, Califor- nia 94305-3301 (US). (74) Agent: DAVY, Brian E.; Bozicevic, Field & Francis LLP, = 201 Redwood Shores Parkway, Suite 200, Redwood City, = California 94065 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = (54) Title: CONJUGATES FOR TARGETED CELL SURFACE EDITING (57) : Provided are conjugates including a targeting moiety that = = FIG. 14 binds to a cell surface molecule of a target cell and a target cell surface-edit- = — ing enzyme. Also provided are compositions and kits that include the conju- Gamma/Delta T cells gates, as well as methods of using the conjugates. Methods of making con- jugates are also provided. = 20 A\" 1 .(7) 1-1 X 0 7r 8 .' M © e © , e .c ' 1 1 4e, © ei 0o C