Patent SG-11201903842Y-A (SG)
Title: Combination treatment with antibody-drug conjugates and parp inhibitors
Inventor: WANG EUNICE SUE
IPC: A61K47/68
Filed: 2017-11-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/085359 Al 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: Declarations under Rule 4.17: A61K 45/06 (2006.01) A61K 31/55 (2006.01) A61K 31/4184 (2006.01) A61K 47/68 (2017.01) — as to applicant's entitlement to apply for and be granted a A61K 31/454 (2006.01) A61P 35/00 (2006.01) patent (Rule 4.17(H)) A61K 31/502 (2006.01) A61P 35/02 (2006.01) — as to the applicant's entitlement to claim the priority of the A61K 31/5025 (2006.01) earlier application (Rule 4.17(iii)) (21) International Application Number: Published: PCT/US2017/059483 — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 01 November 2017 (01.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/416,383 02 November 2016 (02.11.2016) US (71) Applicants: IMMUNOGEN, INC. [US/US]; 830 Win- ter Street, Waltham, MA 02451 (US). HEALTH RESEARCH, INC. [US/US]; Elm & Carlton Streets, Buf- falo, NY 14263 (US). Inventors: WANG, Eunice Sue; 342 Forestview Dri- ve, Williamsville, NY 14221 (US). PORTWOOD, Scott = (72) Michael; 2988 Angle Road, Orchard Park, NY 14127 (US). = — WALKER, Russell; 47 Turner Street, Dedham, MA 02026 = (US). = Agent: LU, Yu et al.; McCarter & English, LLP, 265 (74) = Franklin Street, Boston, MA 02110 (US). Designated States (unless otherwise indicated, for every (81) = — kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, _ KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every (84) = — kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = — Il tz. kin M kin cc EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). © (54) Title: COMBINATION TREATMENT WITH ANTIBODY-DRUG CONJUGATES AND PARP INHIBITORS --.... 00 ,1 (57) : The present invention provides a method of treating a cancer in a subject comprising administering to the subject an 0 effective amount of a CD33-targeted antibody-drug conjugate (ADC) and an effective amount of a poly-ADP ribose polymerase (PARP) \" inhibitor. Also provided are pharmaceutical compositions comprising an effective amount of a CD33-targeted ADC and an effective 0 amount of a PARP inhibitor.