baber/WOPTO huggingface dataset:
Patent CA-3063329-A1 (CA)
Inventor: JACKSON PAUL JOSEPH MARK
IPC: C07D471/04
Filed: 2017-05-12
Abstract: L'invention concerne un composé de formule (I) : A-X1-L-X2-B et ses sels, solvants et tautomères, qui sont utiles en tant que médicament, en particulier en tant qu'agents antiprolifératifs et étant destinés à être utilisés en tant que médicament dans un conjugué anticorps-médicament. Dans la formule (I), A est un groupe choisi parmi (A1), (A2), (A3), (A4) et (A5); X1 et X2 sont indépendamment choisis parmi O, S, NR28, CR28R29, CR28R29O, C(=O), C(=O)NR28, NR28C(=O), C(O)-RA-C(O)-NH, C(O)-RA-NH-C(O), C(O) -NH-RA-C(O), NH-C(O)-RA-C(O), NH-C(O)-RA-C(O)-NH, NH-C(O)-RA-NH-C(O), C(O)-NH-RA-NH-C(O), C(O)-NH-RA-C(O)-NH, O-C(O) et C(O)-O ou est absent; L est choisi parmi un acide aminé, une chaîne peptidique composée de 2 à 12 acides aminés, une chaîne paraformaldéhyde (OCH2)1-24-, une chaîne polyéthylène glycol -(OCH2CH2)1-12- et (CH2)m-Y6-(CH2)n-, Y6 étant choisi parmi (CH2)z- et un groupe (L1); un groupe (L1) qui est choisi parmi des groupes arylène, hétéroarylène monocylcique, cycloalkylène monocyclique, cycloalcénylène monocylcique et hétérocyclylène monocylique, éventuellement substitué par jusqu'à trois groupes substituants optionnels; et B est un groupe polycyclique choisi parmi (B1), (B2) et (B3).
Patent CA-3067047-A1 (CA)
Title: Peptides antimicrobiens stabilises pour le traitement d'infections bacteriennes resistantes aux antibiotiques
Inventor: WALENSKY LOREN D
IPC: C07K14/435
Filed: 2018-07-18
Abstract: L'invention concerne des procédés de production et d'optimisation de peptides antimicrobiens stabilisés (par exemple, agrafés et/ou cousus) (StAMP) pour la prophylaxie et le traitement d'infections bactériennes résistantes aux antibiotiques (par exemple, résistantes à la colistine, résistantes à la méthicilline, résistantes au méropénem) (par exemple, Gram-négatives, Gram-positives), et des procédés d'utilisation de tels peptides pour une étude expérimentale, la gestion du bétail, la gestion de cultures/arbres/plantes et/ou un bénéfice thérapeutique. L'invention concerne également des procédés de réduction de la toxicité rénale d'un StAMP.
Patent CA-3067164-A1 (CA)
Title: Zika virus strains for treatment of glioblastoma
Inventor: DIAMOND MICHAEL
IPC: C07K14/18
Filed: 2018-06-11
Abstract: The present disclosure involves a composition and method of treatment of glioblastoma, using ZIKA virus.
Patent CA-3073634-A1 (CA)
Inventor: SCHLAKE THOMAS
IPC: C12N15/67
Filed: 2018-10-17
Abstract: The present invention provides artificial nucleic acid molecules comprising novel combinations of 5 and 3' untranslated region (UTR) elements. The inventive nucleic acid molecules are preferably characterized by increased expression efficacies of coding regions operably linked to said UTR elements. The artificial nucleic acids can be used for treatment or prophylaxis of various diseases.  The invention further provides (pharmaceutical) compositions, vaccines and kits comprising said artificial nucleic acid molecules.  Further, in vitro methods for preparing artificial nucleic acid molecules according to the invention are provided.
Patent CA-3075324-A1 (CA)
Inventor: LIU DONG
IPC: C07D401/12
Filed: 2018-09-11
Abstract: A deuterium atom-substituted indole formamide derivative, a preparation method therefor, and medical applications thereof. Specifically, the present invention relates to a deuterium atom-substituted indole formamide derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses of the derivative serving as an ROR agonist and uses of the derivative in preventing and/or treating tumors or cancers, definitions of substituent groups in general formula (I) being same as definitions in the specification.
Patent CA-3076338-A1 (CA)
Inventor: PAIGE RONALD D
IPC: F16L37/091
Filed: 2020-03-19
Abstract: A press fitting assembly is provided that includes: a piping component including a receiving device which includes an open end and a shoulder, the open end comprising a continuous stop; a grip ring positioned within the receiving device abutting the continuous stop and comprising a plurality of opposing teeth; a sealing element positioned within the receiving device and abutting the shoulder, wherien the sealing element comprises at least one lobe; and a separator ring positioned within the receiving device between the sealing element and the grip ring, the ring comprises a base portion and an angled portion. Further, the angled portion is angled toward the sealing element and the shoulder.
Patent CA-3079373-A1 (CA)
Inventor: ISHIBASHI TAKASHI
IPC: A61K31/122
Filed: 2018-05-24
Abstract: The present invention relates to a prophylactic agent or an inhibitor for cerebral hypofunction, the agent containing a carotenoid composition or a carotenoid preparation that contains astaxanthin, adonirubin, and adonixanthin at a prescribed ratio.
Patent CA-3081037-A1 (CA)
Title: Production of sioc-bonded polyether siloxanes
Inventor: FAVRESSE PHILIPPE
IPC: B01D19/04
Filed: 2020-05-21
Abstract: The invention relates to a process for producing SiOC-bonded polyether siloxanes by transesterification of alkoxysiloxanes with polyetherols in the presence of trifluoromethanesulfonate as catalyst wherein the computational total water content of the reactants consisting of alkoxysiloxanes and polyetherols is <= 5000 ppm by mass, advantageously <= 300 ppm by mass, preferably <= 150 ppm by mass, more preferably <= 100 ppm by mass, in particular <= 50 ppm by mass, wherein the determination of the individual water contents is performed beforehand, preferably by titration according to Karl Fischer.
Patent CA-3081591-A1 (CA)
Inventor: GALLES MICHAEL BRIAN
IPC: H04L49/111
Filed: 2018-11-05
Abstract: Methods and devices for processing packets with reduced data stalls are provided. The method comprises: (a) receiving a packet comprising a header portion and a payload portion, wherein the header portion is used to generate a packet header vector; (b) producing a table result by performing packet match operations, wherein the table result is generated based at least in part on the packet header vector and data stored in a match table; (c) receiving, at a match processing unit, the table result and an address of a set of instructions associated with the match table; and (d) performing, by the match processing unit, one or more actions in response to the set of instructions until completion of the instructions, wherein the one or more actions comprise modifying the header portion, updating memory based data structure or initiating an event.
Patent CA-3082421-A1 (CA)
Inventor: FANG JIANMIN
IPC: A61K39/00
Filed: 2018-10-31
Abstract: Il est décrit l'utilisation d'un anticorps agoniste de c-MET dans la préparation d'un médicament pour traiter ou prévenir les blessures aux cellules endothéliales vasculaires, en particulier un médicament pour les infarctus cérébraux et les infarctus du myocarde. Un agoniste de c-MET spécifique est aussi décrit.
Patent CA-3084144-A1 (CA)
Inventor: JACKSON MICHELLE
IPC: C12N9/54
Filed: 2018-12-17
Abstract: A phosphate-free automatic dishwashing cleaning composition comprising: i) a protease wherein the protease is a variant having at least 60% identity with the amino acid sequence of SEQ ID NO:1 and comprising at least one amino acid substitution (using the SEQ ID NO: 1 numbering) selected from the group consisting of: X54T; X126A, D, G, V, E, K, I; X127E, S, T, A, P, G, C; and X128E, C, T, D, P, G, L, Y, N; and ii) from 10 to 50% by weight of the composition of a complexing agent system comprising from 0 to less than 30% by weight of the composition of citric acid.
Patent CA-3084579-A1 (CA)
Inventor: WIECZOREK MACIEJ
IPC: A61P25/00
Filed: 2018-12-05
Abstract: La présente invention concerne l'utilisation d'un ligand CD20 et d'au moins un autre agent actif dans le traitement de la sclérose en plaques, l'utilisation d'une composition pharmaceutique et d'un kit comprenant le ligand CD20 et au moins un autre agent actif ou une composition pharmaceutique comprenant un tel ligand CD20 et un autre ingrédient actif.
Patent CA-3084622-A1 (CA)
Title: Improved jar and method of manufacture
Inventor: CHANG JOHN
IPC: B65D1/10
Filed: 2020-06-22
Abstract: In one aspect an improved container is provided comprising an outer container and an inner container, the inner container being present in a false bottom, and utilizing a child proof lid. In one aspect the inner container is made of glass, and affixed to a plastic outer container through an ultraviolet cured adhesive. The combination of a false bottom and a child proof lid.
Patent CA-3088008-A1 (CA)
Title: Method and apparatus for controlling operating mode, and computer storage medium
Inventor: LIU JIANHUA
IPC: H04W52/02
Filed: 2018-01-09
Abstract: Disclosed in the present invention are a method and apparatus for controlling an operating mode, and a computer storage medium. The method comprises: a terminal negotiates with a network device to leave a first operating mode in an inactive state. A terminal negotiates with a network device to leave a first operating mode in an inactive state.
Patent CA-3091243-A1 (CA)
Inventor: ALOUHALI RAED A
IPC: C09K8/508
Filed: 2019-02-13
Abstract: L'invention concerne un procédé et un additif de fluide de forage permettant de réduire les pertes de circulation de fluide importantes dans un puits, comprenant une combinaison de particules granulaires de pneus usagés et d'un adhésif polymère moulé en une forme de capsule. Une fois dans la zone de perte de circulation importante, une pluralité de matériaux de régulation de perte de circulation (LCM) pénètrent dans les fractures de la formation et scellent la zone de perte de circulation importante.
Patent CA-3091302-A1 (CA)
Title: A cabinet frame assembled by folded profiles
Inventor: THING POUL
IPC: H02B1/01
Filed: 2019-02-22
Abstract: The invention relates to a method of establishing four profiles which when releasably mounted together are forming a cabinet frame. The profiles are having folding areas comprising cutout parts.
Patent CA-3091337-A1 (CA)
Title: A real-time open water analysis system
Inventor: WANG LISHAO
IPC: G01N15/10
Filed: 2020-08-27
Abstract: A real-time open water analysis system is disclosed. In one example embodiment, the system collects fluid comprising particles, removes particles from the fluid that are larger than a threshold size, pumps the sample of fluid containing unfiltered particles through a substantially translucent conduit, captures images of the unfiltered particles, and applies a trained machine learning system to the images to determine properties of the unfiltered particles.
Patent CA-3091462-A1 (CA)
Inventor: GOETZ WOLFGANG
IPC: A61B17/064
Filed: 2019-02-28
Abstract: The present invention relates to a medical apparatus for closing an aperture (302), an incision, a puncture, a passage through tissue and/or a communication with a blood vessel or other body lumen (short: aperture) of a tissue (301) of a patient, the medical apparatus comprising a closing device holder (802), for releasably receiving one or more closing devices (600); and a retracting unit (100) to come into contact with opposite sides of the aperture (302) and for retracting them and/or for spreading the aperture (302) causing it to change its shape into a slit or a slit-like or a more slit-like aperture (302) or to spread or to augment the dimension or diameter of the aperture (302) in at least one or in exactly one dimension of the aperture (302).
Patent CA-3093305-A1 (CA)
Title: System and method for securely exchanging messages
Inventor: BOIVIN CEDRIC
IPC: H04L12/58
Filed: 2019-03-08
Abstract: The present system and method allow the exchange of messages, such as email, between a sender and a recipient while maintaining the data secure and the integrity of the content of the messages. The method and system do not require a user having an account to open a received message. The method comprises the server creating a new communication key upon reception of a request. The communication key is typically valid for a single request to ensure that each request is encrypted using different communication keys. The method typically comprises a client [A] establishing communication on [HANDSHAKE] with one or more servers [B]. The HANDSHAKE generally aims at initializing the encryption key that will be used to exchange information between A and B.
Patent CA-3093353-A1 (CA)
Inventor: BRINKMEYER MARC
IPC: B27M1/02
Filed: 2020-09-16
Abstract: ABSTRACT The technology disclosed relates to moisture removal from wood materials. In particular, it relates to a press that includes a continuous and liquid permeable sheet metal band that makes use of viaways, grooves, perforations, or combinations thereof allowing liquid to permeate therethrough. The press can also include a first pressing roller located above the sheet metal band and a first anvil roller located below the sheet metal band and forming a first nip with the first pressing roller and the sheet metal band, such that the sheet metal band being located between the first pressing roller and the first anvil roller. Date Recue/Date Received 2020-09-16
Patent CA-3093452-A1 (CA)
Title: Surgical robotic systems
Inventor: KAPADIA JAIMEEN
IPC: A61B34/00
Filed: 2019-03-28
Abstract: A surgical robotic system includes an elongated slide and a carriage for supporting an instrument drive unit. The slide includes an inner shaft and an outer sleeve disposed about the inner shaft. The outer sleeve is configured to move relative to the inner shaft along a longitudinal axis defined by the slide between a retracted position, in which the slide has a first length, and an extended position, in which the slide has a second length, greater than the first length. The carriage is coupled to the outer sleeve and movable relative to the outer sleeve along the longitudinal axis.
Patent CA-3094013-A1 (CA)
Title: Recyclable container and lidding construction
Inventor: TRUITT MARY KATHERINE
IPC: B65D43/14
Filed: 2020-09-23
Abstract: ABSTRACT The invention comprises a resealable, recyclable container structure comprising a polymeric rigid tray and a flexible polymeric film lidding. The tray has a bottom wall and at least one upwardly extending sidewall. The at least one sidewall terminates in a flange and the flange comprises at least one resealable zone and at least one permanently affixed zone. The lidding is permanently affixed to the flange in the permanently affixed zone and resealably affixed to the flange in the resealable zone.  The polymeric rigid tray and the polymeric film comprise the same polymer. Date Recue/Date Received 2020-09-23
Patent CA-3095094-A1 (CA)
Title: Cutting tool and cutting insert having complementary engagement features for eccentric mounting
Inventor: IRLIN SERGEY
IPC: B23C5/22
Filed: 2019-03-04
Abstract: A cutting tool (20) has a tool body (22) with a first insert pocket (24) and an indexable cutting insert (26) removably mounted therein. The first insert pocket has a first seat surface with a plurality of first engagement elements and a first support wall transverse thereto. The cutting insert has upper and lower surfaces and a boundary surface extending therebetween. The lower surface has a plurality of lower engaging elements and the boundary surface has a plurality of alternating first and second peripheral surfaces intersecting the upper surface to form first and second upper cutting edges. In each index position with the lower surface in contact with the first seat surface, the first support wall prevents translation of the cutting insert in a first direction, and the first engagement elements eccentrically contact the lower engaging elements to prevent translation of the cutting insert in a second direction perpendicular to the first direction.
Patent CA-3097580-A1 (CA)
Inventor: BANGALORE SUNDARA RAJU GIRIDHAR
IPC: B60L53/50
Filed: 2020-10-30
Abstract: A microgrid system that supports EV charging. The microgrid system powers the load with one or more renewable energy sources (for example, solar, wind), battery storage, in combination with optional access to limited utility power and automatically- controlled generator power as a backup. The system can deliver clean uninterrupted power. The system provides flexibility to support the export of power for net metering, gross metering or peer-peer trading, as permitted by local regulations. The system includes a main storage sub-system and an optional secondary storage that may be brought online and increased or decreased as needed, and optimized based on guidance provided by the microgrid controller. The system also includes modules that decide how to optimally use the energy from the various sources, in order to maximize renewable energy usage, minimize the cost of electricity, while maximizing the life of the system.
Patent CA-3099124-A1 (CA)
Title: Solid state lighting device providing spectral power distribution with enhanced perceived brightness
Inventor: ZHANG FAN
IPC: H05B44/00
Filed: 2019-05-03
Abstract: A solid state lighting device includes at least one electrically activated solid state light emitter configured to stimulate emissions of first through third lumiphoric materials having peak wavelengths in ranges of from 485 nm to 530 nm, from 575 nm to 612 nm, and from 605 nm to 640 nm, respectively (or subranges thereof defined herein), with the third peak having a full width half maximum value of less than 60 nm. The resulting device generates aggregated emissions having a suitably high color rendering index (e.g., CRI Ra) value (e.g., at least 70), and also having a spectral power distribution with a Melanopic/Photopic ratio within a specified target range as a function of correlated color temperature, thereby providing increased perceived brightness.
Patent CA-3099938-A1 (CA)
Title: System and method for supplying electric energy to a mining vehicle and a mining vehicle
Inventor: KOUVO MIKKO
IPC: H02J1/08
Filed: 2019-05-16
Abstract: The invention relates to a system and method for supplying electric energy to a mining vehicle and a mining vehicle. In the presented solution electric energy is supplied to a mining vehicle using a system comprising a bipolar LVDC supply having a certain total voltage. The mining vehicle comprises at least a first energy unit and a second energy unit. The first energy unit is connected to a part of said certain total voltage and the second energy unit is connected to another part of said certain total voltage.
Patent CA-3100996-A1 (CA)
Inventor: DONHOFFNER ROBERT ANTHONY
IPC: G08G5/00
Filed: 2019-05-24
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving aircraft transponder signals. Identifying, from among the aircraft transponder signals, a first aircraft transponders signal based on an identifier, wherein the identifier indicates that the first aircraft transponder signal is associated with an aircraft on which the computing system is located. Identifying first location data within the first aircraft transponder signal. Generating second location data by converting the first location data to a format recognizable by a geographic mapping application, where the second location data is readable by the geographic mapping application to permit the geographic mapping application to present a graphical representation of a geographical location of the aircraft as represented by the first location data. Providing the second location data to the geographic mapping application for presentation to a user.
Patent CA-3101505-A1 (CA)
Inventor: DIPERSIO JOHN F
IPC: A61K35/17
Filed: 2019-05-31
Abstract: L'invention concerne des lymphocytes T à récepteurs d'antigènes chimériques (CAR-T) édités par le génome, qui peuvent être dérivés d'un lymphocyte T cytotoxique, d'un lymphocyte T cytotoxique spécifique d'un virus, de lymphocytes T de mémoire ou de lymphocytes T gamma delta (yd), et comprennent un ou plusieurs récepteurs d'antigènes chimériques (CAR) ciblant un ou plusieurs antigènes, le lymphocyte CAR-T étant déficient en un ou plusieurs antigènes auxquels le ou les CAR se lient spécifiquement. En particulier, la présente invention concerne des lymphocytes T à récepteurs d'antigènes chimériques (CAR) mono, doubles et tandem modifiés et des procédés d'immunothérapie pour le traitement du cancer.
Patent CA-3101828-A1 (CA)
Title: Low-profile multi-agent injection system and methods
Inventor: STREETER JOHN
IPC: A61M5/32
Filed: 2019-05-31
Abstract: Low-profile fluid injection systems and methods for injecting fluid into a tumor within a body comprising an elongate member, a plurality of fluid delivery members, and a plurality of fluid reservoirs. Each of the plurality of fluid reservoirs may be fluidly coupled to a single of fluid delivery lumen of a single fluid delivery member such that each of the fluid delivery members is fluidly independent of every other fluid delivery member. The plurality of fluid delivery members may be configured to extend out of a distal end of the elongate member into the tumor when the system is positioned in the body of a patient. A fluid delivery mechanism may be operably coupled to the plurality of fluid reservoirs in order to deliver fluids from the plurality of fluid reservoirs to the plurality of fluid delivery members and inject the fluids into the tumor.
Patent CA-3103358-A1 (CA)
Inventor: TEBOUL DANIEL
IPC: B03C3/70
Filed: 2019-06-13
Abstract: The invention relates to a device for purifying a gaseous medium loaded with particles comprising a shell (11) closed at the ends thereof by an end plate (31) protected by a disjoined shell (70), an electrostatic filtration chamber (20) having a passage for the gaseous medium loaded with particles; said chamber (20) comprising an emissive structure (40) comprising serrated plates (42) forming tips (47) directed towards a collecting structure (50) on either side of said emissive structure (40) and designed to trap the particles contained in the gaseous medium; said end plate (31) and said shell (70) are each brought to a different predetermined potential so as to create an electric repulsion field in the vicinity of said end plate (31), directed towards said passage.
Patent CA-3105970-A1 (CA)
Title: Contactless button of elevator
Inventor: WANG KE
IPC: B66B1/14
Filed: 2021-01-19
Abstract: Buttons on elevators are operated by touching, which is known as one of the main ways of spreading virus. The device comprises a button panel, a piece of glass pane, infrared sensors, optical sensors, buttons, and a controller. In this invention, an activating signal is recognized by the optical sensor when the operator seeks a finger close to the optical sensor and is transmitd to the elevator button system. In this way, users are able to operate the elevator without contacting any button.
Patent CA-3110519-A1 (CA)
Inventor: HILLIER MICHAEL
IPC: A61K31/454
Filed: 2019-08-29
Abstract: The present invention relates to compositions of pibrentasvir, drug products thereof, and processes and intermediates for the preparation thereof. This invention relates to the drug product, active drug substance, intermediates, and processes of pibrentasvir, a NS5A inhibitor that is useful in the treatment of hepatitis C.
Patent CA-3112410-A1 (CA)
Inventor: HIGGINSON DANIEL SMITH
IPC: C07H21/04
Filed: 2019-09-10
Abstract: The present invention provides methods and compositions for the detection of HPV DNA in patient samples with high sensitivity and specificity. Such methods are useful in screening for HPV-associated malignancies. In some embodiments the present invention provides methods and compositions for the detection of HPV16, HPV33 and/or HP VI 8 DNA. In some embodiments the present invention provides methods and compositions for the detection of HPV DNA from squamous cell carcinomas, such as oropharyngeal squamous cell carcinomas and anal squamous cell carcinomas.