baber/WOPTO huggingface dataset:
Patent EP-0537905-B1 (EP)
Inventor: KINGSTON DAVID G I
IPC: A61K31/335
Filed: 1992-09-16
Granted: 1996-03-06
Abstract: Sulfonated 2'-acryloyltaxol and sulfonated 2'-O-acyl acid taxol derivatives having the following general structure, <CHEM>  where R is CX=CYZ,  wherein: X, Y and Z are each selected from the group consisting of H, alkyls and aryls; and when one of Y or Z is H, the other is different from X;  or R is CWX-CYZ-SO<6>O-M,  wherein: W, X, Y, Z are each selected from the group consisting of H, alkyls and aryls; M is selected from the group consisting of H, alkaline metals and ammonio groups; and if W or X is H, then CWX is different from CYZ, are synthesized which have improved water solubility and stability while maintaining bio-activity. In particular, 2'-Ä(3-sulfo-1-oxopropyl)oxyÜtaxol sodium salt is synthesized by reacting taxol with acrylic acid, and subsequently reacting the 2'-acryloyltaxol with bisulfite in a Michael reaction. 2'-äÄ4-((2-sulfoethyl)amino)-1,4-dioxobutylÜoxyütaxol sodium salt and 2'-äÄ4-((3-sulfopropyl)amino)1,4-dioxobutylÜoxyütaxol sodium salt are synthesized by reacting 2'-succinyltaxol with the tetrabutylammonium salts of taurine and 3-aminopropyl sulfonic acid, respectively, and subsequently exchanging the ammonium with sodium.
Patent EP-0540210-B1 (EP)
Inventor: CONDER MICHAEL J
IPC: C12N1/19
Filed: 1992-10-14
Granted: 1998-12-02
Abstract: Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:   1) an expandase gene, e.g., from Cephalosporium acremonium, whose expression product converts the adipoyl-6-APA by ring expansion to adipoyl-7-ADCA; 2) an hydroxylase gene whose expression product converts the 3-methyl side chain of adipoyl-7-ADCA to 3-hydroxymethyl, to give the first product, adipoyl-7-aminodeacetylcephalosporanic acid (7-ADAC); and 3) an acetyltransferase gene whose expression product converts the 3-hydroxymethyl side chain to the 3-acetyloxymethyl side chain of adipoyl-7-ACA. The final product, 7-ACA, is then prepared by cleavage of the adipoyl side chain using an adipoyl acylase. The entire synthesis, accordingly, is carried out using bioprocesses, and is efficient and economical.
Patent EP-0505270-B1 (EP)
Inventor: POL VINCENT
IPC: A61M60/443
Filed: 1992-03-18
Granted: 1996-01-31
Abstract: The invention relates to an implantable blood pump of the type comprising a shell, a closed deformable bag, an inlet valve and an outlet valve, a drum arranged to roll over a wall of the bag, a bracket mounted to rotate about the axis of the drum and connected by an inextensible flexible component to one of the end edges of the bag, and an electric motor integrated inside the drum and suitable for driving the bracket and the drum in mutual and antagonistic rotation over a fraction of a turn to compress the bag which winds onto the drum to expel blood fluid. According to the invention, the outer shell is rigid and constitutes a sealed housing in which the bag can deform, and the bag is made, at least in part, of a material that is inextensible in two directions so that its original volume remains constant, said bag thus being made insensitive to external underpressure tending to increase its volume while blood fluid is being expelled. The invention is applicable to making non-displacement peristaltic cardiac prosthesis.
Patent EP-0646189-B1 (EP)
Inventor: COLLINS ROBERT JAMES
IPC: D02J1/22
Filed: 1992-01-29
Granted: 1997-08-20
Abstract: On prépare de minces filaments de polyester dont la qualité mécanique et l'uniformité sont excellentes, et présentant de préférence un équilibre de bonne qualité de teinture et de rétrécicement,  à l'aide d'un procédé simplifié d'orientation du filage direct dans lequel on sélectionne la viscosité du polymère et les conditions du filage.
Patent EP-0575363-B1 (EP)
Inventor: CHAPELON JEAN-YVES
IPC: A61F7/00
Filed: 1992-02-25
Granted: 2002-10-23
Abstract: A therapeutic endo-rectal probe comprises at least a piezoelectric transducer element mounted in a support member itself connected to a rigid guide means enabling endo-rectal insertion of said probe, the outside shape of said support member preferably being that of a disk having an outline that is for the most part substantially circular or substantially elliptical, thereby facilitating endo-rectal insertion.   <IMAGE>
Patent EP-0610265-B1 (EP)
Inventor: BARBACHYN MICHAEL ROBERT
IPC: C07D277/40
Filed: 1992-10-05
Granted: 1996-12-27
Abstract: The present invention discloses novel substituted aryl- and heteroarylphenyloxazolidinones which are useful as anti-bacterial agents. More specifically, the substituted aryl- and heteroarylphenyloxazolidinones of the invention are characterized by oxazolidinones having an aryl or heteroaryl group at the p-position of the 3-phenyl ring and additional substitutions at the m-position(s) of the 3-phenyl ring. A compound representative of this new class of oxazolidinones is (+/-)-5-(acetamidomethyl)-3-[4-(3-pyridyl)-3,5-difluorophenyl]-2-oxazolidinone.
Patent EP-0577233-B1 (EP)
Inventor: HUETTNER PETER DIPL-ING
IPC: H01B7/28
Filed: 1993-05-12
Granted: 1996-01-31
Abstract: The invention relates to a power cable with a screen (6) constructed of wires. To meet the various demands on the padding of the shield, the fixing of the shield wires and the longitudinal water tightness with a single tape material (5) to be arranged beneath the shield, said tape material consists of a non-woven fabric/foam laminate with the foam layer (52) disposed on the outside, the moisture-activatable swelling powder (53) being arranged between the two laminate layers (51, 52). <IMAGE>
Patent EP-0635193-B1 (EP)
Inventor: LEEB KARL-ERIK
IPC: H05K5/06
Filed: 1993-02-11
Granted: 1997-03-26
Abstract: The present invention relates to a device for flexibly encasing electronic circuitry, where an electronic circuit (1) is enclosed in a casing which comprises a laminate (2) consisting of metal and plastic sheets such as to form a diffusion impervious and electrically conductive structure which prevents harmful substances from reaching the electronic circuit (1) and also prevents inductive electromagnetic exchange. Electrical conductors (3) pass through the joint region (4) of the laminate (2).
Patent EP-0613705-B1 (EP)
Inventor: BALBINOT RENZO
IPC: A63C17/14
Filed: 1994-02-21
Granted: 1997-11-05
Abstract: Braking device particularly usable for skates including a shoe (2) composed of a quarter (4) articulated to a shell (5) which is in turn associated with a supporting frame (6) for two or more wheels (7). A brake (9) is associated with the quarter and selectively interacts with the ground upon a backward rotation of the quarter. <IMAGE>
Patent EP-0617065-B1 (EP)
Inventor: SIOL WERNER DR
IPC: C08F220/12
Filed: 1994-03-23
Granted: 2001-07-18
Abstract: The invention relates to acrylate-based thermoplastic elastomers comprising at least 40% by weight and up to 100% by weight of one or more combpolymers KP having a molecular weight of greater than 50,000 daltons which are built up from   alpha ) 5-50% by weight of macromonomers MM built up from methyl methacrylate or copolymers of methyl methacrylate with comonomers selected from the group consisting of further methacrylates, acrylates and styrenes, containing a terminal unit with a free-radical-polymerisable group having a glass transition temperature Tg of at least 60 degrees C and a molecular weight in the range of from 500 to 100,000 daltons and a refractive index nD in the range from 1.48 to 1.50, and beta ) from 5 to 90% by weight (based on all the monomers in the KP) of monomers or monomer mixtures of the formula I <IMAGE>  in which R1 is an alkyl group having 1 to 12 carbon atoms, and gamma ) from 5 to 50% by weight (based on all the monomers in the KP) of a phenyl-containing, free-radical-polymerisable monomer PHM
Patent EP-0620308-B1 (EP)
Inventor: WILLIAMS JOHN JULIAN AUBREY
IPC: H02K15/12
Filed: 1989-09-20
Granted: 1998-08-12
Abstract: An electric motor (30) stator (31) and rotor (51 to 55) are made by holding magnetic elements (32, 53) thereof in position in dies (25; 66 to 69) and injecting a plastics material into the dies to provide bearing carrier mountings (27, 51) substantially concentric with the pole faces (33) of the stator (31) and poles (53) of the rotor. The motor is completed by providing a bearing (21) in the stator bearing carrier mounting (27) and a shaft (13) in the rotor bearing carrier mounting (51), the shaft running also in a further bearing mounting tube (8). The motor and drive so made is mounted to drive an agitator (7) and spin tub (4) of a laundry machine (1). <IMAGE>
Patent EP-0627526-B1 (EP)
Inventor: BRAUNGARDT RUDOLF
IPC: E01C11/22
Filed: 1994-04-26
Granted: 1997-01-29
Abstract: The approximately vertical side walls (2) of the paving stone (1) are inwardly offset in their lower part (6) with respect to the upper part (7) of the side wall (2). In this way, upon setting the paving stones (1) against one another, a cavity (8) which is open at the bottom results between two adjacent paving stones (1) in the lower part of the side walls (2). The communication of the cavities (8), interconnected in the manner of a drainage system, with the surface of the paving stones laid virtually without gaps is established by a vertical recess (9) in the upper part of the side walls (2) of the paving stones (1). Rapid and reliable drainage of the rainwater into the soil is thereby made possible. <IMAGE>
Patent EP-0635627-B1 (EP)
Inventor: WHITTENBERGER WILLIAM A
IPC: F01N3/28
Filed: 1994-05-16
Granted: 1997-10-01
Abstract: An improved converter body for carrying out chemical reactions, such as oxidation, and especially oxidation of pollutant materials in exhaust streams, which converter (122) includes an electrically heatable portion (90) characterized by a multicellular honeycomb monolith and an integral non-electrically heatable multicellular honeycomb "light-off" portion (92) each constructed of thin sheet metal layers. The electrically heatable portion (90) has a surface area of from 200 to 700 square inches and is capable of being rapidly heated to a temperature of from 400 F to 900 F in a period of from about 2 to about 40 seconds from a voltage source delivering at least 500 watts of power, and the electrically heatable honeycomb portion has a cell density of from 40 to 500 cells per square inch. The "light-off" portion (92) has a surface area in the range of from 800 to 5000 square inches and a cell density of from 200 to 750 cells per square inch.
Patent EP-0626096-B1 (EP)
Inventor: EDDS THOMAS A
IPC: H01H9/46
Filed: 1993-11-12
Granted: 1997-07-16
Abstract: Dispositif de suppression d'arc (50) destiné à être installé sur le cheminement prédéterminé d'un mouvement entre deux contacts électriques (16, 18) d'un réseau de distribution électrique. Le dispositif (50) comporte un élément formant berceau (54) d'une forme générale en U, réalisé dans une composition thermoplastique et comportant au minimum trois fentes (72, 74, 76). Une plaque en U (78) est prévue pour chaque série de trois fentes (72, 74, 76). Chacune des plaques (78) est maintenue solidaire du berceau (54), le dispositif de fixation (92) faisant partie intégrante de ce dernier. Chaque plaque (78) est réalisée, de manière appropriée, dans un métal magnétique et une composition thermoplastique conductrice.
Patent EP-0675882-B1 (EP)
Title: 5-aryl-1,3-thiazin derivate, deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
Inventor: FISCHER REINER
IPC: C07D417/04
Filed: 1993-12-10
Granted: 2001-11-14
Abstract: Die vorliegende Erfindung betrifft die neuen substituierten 5-Aryl-1,3-thiazin-Derivate der allgemeinen Formel (I), als Schädlingsbekämpfungsmittel, vorzugsweise als Arthropodizide, Nematizide und Herbizide sowie als Ekto- und Endoparasitizide.
Patent EP-0682762-B1 (EP)
Inventor: ZURMUEHLEN GUENTER
IPC: F22G5/12
Filed: 1994-01-18
Granted: 1997-04-02
Abstract: PCT No. PCT/EP94/00113 Sec. 371 Date Sep. 12, 1995 Sec. 102(e) Date Sep. 12, 1995 PCT Filed Jan. 18, 1994 PCT Pub. No. WO94/18499 PCT Pub. Date Aug. 18, 1994The invention is directed to a spray cooler for regulating the temperature of superheated steam with a stream of cooling water. Its primary inventive feature is directed to a throttle area which has a continuously widening cross section disposed on a piston rod and arranged between the cooling water inlet opening and the nozzles of the spray cooler. The throttle area serves to regulate the pressure the cooling water in proportion to the movement of the piston carrying the throttle.
Patent EP-0699029-B1 (EP)
Inventor: THIND BHARAT BHUSHAN
IPC: A01M1/10
Filed: 1994-04-29
Granted: 2000-01-19
Abstract: PCT No. PCT/GB94/00916 Sec. 371 Date Nov. 3, 1995 Sec. 102(e) Date Nov. 3, 1995 PCT Filed Apr. 29, 1994 PCT Pub. No. WO94/24859 PCT Pub. Date Nov. 10, 1994A bait is provided particularly adapted for attracting and arresting mites such that when used in a particular trap it allows non-destructive collection of mites from a produce. This enables study and enumeration of mites to be more easily carried out than with previous bait/trap combinations. The bait takes the form of an aqueous gel body which is then mounted within an apertured container which forms the trap. The gel may further contain other attractant and arrestant components and its use allows mechanical trapping mechanisms to be dispensed with. A method of assessing infestation status and a trap for mounting the bait are also provided, together with methods for using the bait and/or trap as a microbial detector.
Patent EP-0699072-B1 (EP)
Inventor: MANDEVILLE W HARRY III
IPC: A61P3/02
Filed: 1994-05-16
Granted: 2003-04-23
Abstract: Iron binding polymers are provided for decreasing the absorption of iron from the gastrointestinal tract. The polymers are orally administered, and are useful for treatment of iron overload disorders.
Patent EP-0702814-B1 (EP)
Inventor: BIESMANS JEAN
IPC: G06Q10/00
Filed: 1994-06-09
Granted: 1997-03-12
Abstract: La présente invention a pour objet un dispositif de contrôle de date de péremption. Il est constitué d'un boîtier (1) équipé d'un clavier simplifié (2) comportant uniquement les touches correspondant aux dix chiffres (6) et quelques touches de commande (7, 11), d'un écran (3) numérique indiquant un numéro de produit (20) et sa durée en semaines (21) ou sa date de péremption, d'une alarme visuelle et sonore (4), et de circuits internes constitués d'une alimentation électrique, d'une batterie tampon, d'une horloge, d'une mémoire et d'un microprocesseur associé à un programme spécifique pilotant l'ensemble, chaque produit étant repéré grâce à une étiquette ou pastille programmable portant un numéro ou un code attribué par l'appareil au moment de la saisie de la durée de validité du produit. Il est destiné tout particulièrement à un usage domestique, pour vérifier la validité des produits surgelés.
Patent EP-0702721-B1 (EP)
Inventor: FRENKEN LEON GERARDUS JOSEPH
IPC: C12N15/80
Filed: 1994-06-09
Granted: 2001-01-03
Abstract: The present invention provides a process for producing fusion proteins comprising ScFv fragments by a transformed Aspergillus mould containing a DNA sequence encoding the ScFV fragment under control of at least one expression and/or secretion regulating region derived from a mould selected from the group consisting of promoter sequences, terminator sequences and signal sequence-encoding DNA sequences or functional derivatives or analogues thereof. Such regulating region can be derived from the endoxylanase II gene (exlA gene) of Aspergillus niger var. awamori present on plasmid pAW14B or can be the combination of both a promoter and a signal sequence-encoding DNA sequence derived from a glucoamylase gene ex Aspergillus plus a terminator sequence of a trpC gene ex Aspergillus. Preferably a fusion protein comprising "secreted mould protein - (KEX2 -) ScFv" is produced. Also provided are new products comprising an ScFv fragment or fusion product thereof, compositions, e.g. consumer products, containing both old and new products so produced. Preferably the ScFv fragment recognizes a compound present in the human eco-system, such as microorganisms or enzymes. Such compounds can be present in the oral cavity, e.g. involved in the formation of plaque, caries, gingivitis, periodontal diseases, or bad breath, or on the human skin, e.g. involved in the formation of malodour, inflammation or hair loss, or can be a hormone, e.g. HCG.
Patent EP-0708947-B1 (EP)
Inventor: PIFFERI PIER GIORGIO
IPC: B41M3/14
Filed: 1994-07-06
Granted: 1997-10-29
Abstract: PCT No. PCT/IT94/00107 Sec. 371 Date Jan. 11, 1996 Sec. 102(e) Date Jan. 11, 1996 PCT Filed Jul. 6, 1994 PCT Pub. No. WO95/02869 PCT Pub. Date Jan. 26, 1995This invention relates to a solution for detecting counterfeit paper currency. The solution contains iodine at a concentration of from 0.005 to 3 grams/liter and one or more solvents selected from the groups consisting of: alcohols, ketones, polyalcohols, esters, ethers, or mixtures thereof of solvents belonging to the same group or to several groups of these solvents. The solvent, if miscible with water, contains distilled water in a ratio of from 99:1 to 1:99 parts by volume. If not miscible in water, the solvent is saturated with distilled water at a temperature of 20 DEG  C. The solution is preferably contained in ballpoint pens, fountain pens or other similar dispensers which are then used to countersign the paper currency. A counterfeit currency will cause a visible line to appear on the currency, in about one minute. However, in the case of genuine paper currency, the drawn line of solution does not change color and disappears completely from the countersigned currency.
Patent EP-0664676-B1 (EP)
Title: Apparatus and method for producing a frozen novelty
Inventor: FAZIO PAUL L
IPC: A23P1/12
Filed: 1994-08-11
Granted: 1999-12-29
Abstract: A method for forming composite ice cream-like edible novelties having discrete doughy additions therein. The method involves first providing an extrusion apparatus including a main die having an entrance and an exit disposed downstream of the entrance, and at least one intermediate die positioned within the main die at a location upstream of the exit of the main die. An ice cream-like composition is introduced to the entrance of the main die in at least a semi-frozen state, and a flowable discrete doughy addition is extruded through the intermediate die at an elevated temperature. The ice cream-like composition and the discrete doughy addition are extruded together through the exit of the main die to form the composite ice cream-like edible novelty.
Patent EP-0719236-B1 (EP)
Inventor: CROSS PETER FRANK
IPC: B01J8/02
Filed: 1994-09-13
Granted: 1998-04-29
Abstract: An improved process for continuous recovery of elemental sulphur from sulphur-bearing gas streams, especially for use in a Claus plant, employs a cyclically varying temperature profile through a catalytic bed, such that at least part of the bed is maintained as a "cold" zone at a temperature in the range 125 to 180  DEG C to promote conversion to elemental sulphur, and each part of the bed periodically becomes a "hot" zone at a temperature in the range 190 to 375  DEG C to effect removal of elemental sulphur deposits from the bed.
Patent EP-0731734-B1 (EP)
Inventor: JAERVENPAEAE VILJO
IPC: B01D45/12
Filed: 1994-10-25
Granted: 2000-05-31
Abstract: PCT No. PCT/FI94/00482 Sec. 371 Date Jul. 10, 1996 Sec. 102(e) Date Jul. 10, 1996 PCT Filed Oct. 25, 1994 PCT Pub. No. WO95/14535 PCT Pub. Date Jun. 1, 1995A method and apparatus for improving the separation efficiency of a cyclone separator intended for gaseous medium flows in which an incoming gaseous medium flow to be cleansed is directed into the cyclone separator through an inlet duct such that the incoming medium flow ends up in a downward, revolving flow movement inside the cyclone separator until the incoming medium flow reaches a bottom end of a conical lower part of the cyclone separator, and then becomes a revolving tornado flow that flows in a generally upward direction opposite to the direction of the downward, revolving flow movement. An outlet flow of cleansed gaseous medium is directed through a center pipe situated in the cyclone separator. A component-flow pipe is arranged in the center pipe such that the component-flow pipe has an inlet opening in a wall of the center pipe. A component flow of the incoming medium flow is passed from a location within the cyclone separator through the inlet opening in the wall of the center pipe into the component-flow pipe directed out of the component-flow pipe against the tornado flow such that the component flow disintegrates the tornado flow and thereby prevents solid matter from being carried along with the tornado flow through the center pipe into the outlet flow of the cleansed medium flow.
Patent EP-0671506-B1 (EP)
Inventor: DETTLING BERNHARD
IPC: D21H19/82
Filed: 1995-02-24
Granted: 1996-12-11
Abstract: The paper or cardboard (1) has an undercoat (2) in a coating mass composed of water, amorphous silicon oxide, aluminium oxide, PVA and a copolymer of styrene,butadiene and acrylonitrile. Alternatively it is composed of water, silicic acid or precipitated silicic acid, PVA and a copolymer of styrene, butadiene and acrylonitrile. The covering layer (3) is a coated mass of water with a copolymer of styrene and butadiene modified with carnauba and paraffin wax, an ethylene/methacrylic acid dispersion and polyvinyl acetate. It can use carboxylated styrene-butadiene or styrene-acrylate copolymer dispersion.
Patent EP-0688909-B1 (EP)
Inventor: HUMPERT JUERGEN
IPC: E03C1/05
Filed: 1995-05-29
Granted: 1999-03-10
Abstract: An electrically controlled water outlet fitting has a main body (120 that receives and insert (11) that has a rotary mixing valve (4) that varies the amount of hot and cold water supplied from inlet, pipes (113). The insert has a recess that receives an electronic module (2). This is battery (22) powered and is removed by releasing a screw (3). The cover is removed to replace the battery, the valve is adjusted by the operation of an electromagnetic actuator (32). <IMAGE>
Patent EP-0703652-B1 (EP)
Inventor: SCHAAL CHRISTIAN DIPL-ING
IPC: H02M7/493
Filed: 1995-09-04
Granted: 1998-06-03
Abstract: The method involves determining the load components of the converters (1,2,3) which are connected in parallel, by a controller (8). The total current requirement of the load (61,71) is defined by a total current regulator (63,73) and is limited by the maximum current of the converters supplying the load. The predefined total current requirement of the load is distributed between the converters supplying the load by a balancing controller (65,75), whereby the current component for a supplying converter is limited by its maximum current level. When a converter is switched away from the load, the desired current value for the total current regulator is limited to maximum current for the remaining supplying converters.
Patent EP-0702090-B1 (EP)
Inventor: BACKUS JOHN WESLEY
IPC: C12Q1/6832
Filed: 1995-09-14
Granted: 2004-05-06
Abstract: Multiple target nucleic acids are amplified using polymerase chain reaction in the presence of a nonionic, polymeric volume exclusion agent. The amplification efficiency of low copy target nucleic acids is increased in the presence of the volume exclusion agent even though reduced primer levels are used. In this manner, amplification efficiency of a given target nucleic acid can be more readily manipulated.
Patent EP-0715121-B1 (EP)
Inventor: WOLFER PATRICK
IPC: F22B1/30
Filed: 1995-10-30
Granted: 1998-08-26
Abstract: Turbulence is generated in water from time-to-time by the admission of air or steam to the water through a lower inlet (8,9,9a). A suitable tank (1) assembly incorporates a water inlet (5) with heater (2,3), a gas outlet (1a) and a sludge sediment drain (6,7). Also claimed is a steam generator.