baber/WOPTO huggingface dataset:
Patent CR-20210071-A (CR)
Title: Fused pyrazine derivatives as a2a / a2b inhibitors
Inventor: ZHU WENYU
IPC: C07D519/00
Filed: 2019-07-03
Abstract: This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.
Patent CR-20220628-A (CR)
Title: Antibodies binding to cd3
Inventor: CARPY GUTIERREZ CIRLOS ALEJANDRO
IPC: C07K16/46
Filed: 2021-06-17
Abstract: The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
Patent EC-SP003554-A (EC)
Title: Inhibidores altamente selectivos para la recuperacion de la norepinefrina y metodos para utilizar los mismos
Inventor: WONG ERIK HO FONG
IPC: C07D205/00
Filed: 2000-06-30
Abstract: Metodos y composiciones para trarar a humanos que sufren de, ó prevenir que un humano sufra de una enfermedad, desórden o una condición psicológica o psiquiátrica, medinate la cual se prohibe la recuperación de la norepinefrina es un beneficio, tal como se divulga en el presente texto. Las composiciones comprenden de un compuesto que tiene una selectividad farmacológica de serotonina (Ki)/norepinefrina (Ki) de por lo menos aproximadamente 5000. Ejemplos de dichos compuestos incluyen reboxetina y más preferiblemente un enantiómero de reboxetina ópticamente puro (S,S). Los métodos generalmente incluyen la administración de una cantidad terapéutica de dichas composiciones. Adicionalmente se divulga las preparaciones de un medicamento de la composición y usos de la composición en la preparación del medicamento para tratar a humanos que sufren de, o prevenir a un humano que sufra de una enfermedad desórden o condición psicológica o psiquiátrica.
Patent EC-SP045076-A (EC)
Title: Preparacion y uso de derivados de imidazol para el tratamiento de la obesidad
IPC: C07D409/14
Filed: 2004-04-22
Abstract: Esta invención se refiere a derivados de imidazol sustituido que, según se encontró, suprimen el apetito e inducen la pérdida de peso. La invención suministra también métodos para la síntesis de los compuestos, composiciones farmacéuticas que comprenden los compuestos y métodos de uso de dichas composiciones para inducir la pérdida de peso y tratar la obesidad y trastornos relacionados con la obesidad.
Patent EC-SP045464-A (EC)
Title: Nuevos ésteres de etonogestrel y su uso
IPC: A61K31/565
Filed: 2004-11-29
Abstract: La presente invención se refiere a un kit anticonceptivo y/o de terapia de reemplazo hormonal que comprende una cantidad anticonceptiva o terapéuticamente efectiva de un éster de etonogestrel de larga acción con una longitud de cadena grasa de C7-C15.
Patent EC-SP088331-A (EC)
Title: Cateter anti microbiano
Inventor: RAKE KENNETH WAYNE
IPC: A61M25/00
Filed: 2008-03-28
Abstract: Un catéter para entrega de fluido que comprende:un tubo elongado que tiene una pluralidad de agujeros de salida a lo largo de la longitud de dicho tubo para definir una sección de infusión de dicho catéter, siendo dicho tubo del tamaño que se pueda insertar en una región anatómica, yun miembro elongado colocado dentro de dicho tubo y que está formado de un material poroso configurado para controlar una velocidad de fluido a través de dicho miembro, dicho catéter configurado de tal manera que un fluido introducido dentro de un extremo proximal de dicho tubo fluirá a través de dichos agujeros de salida; donde al menos uno de dicho tubo y dicho miembro elongado incorpora una sustancia anti microbiana y está configurado para la liberación sostenida de dicha sustancia anti microbiana en dicho fluido.
Patent EC-SP972081-A (EC)
Title: Cinta de materia plastica para la fabricacion de tubos arrollados en forma helicoidal
Inventor: ZIMMERLI RUDOLF
IPC: B21C37/20
Filed: 1997-04-15
Abstract: La cinta de materia plástica apta para la fabricación de tubos arrollados está provisto de dos bordes formados complementariamente (1,2), cada uno de los cuales está previsto de nervios (5,6) y ranuras (7,8) desarrollándose paralelamente, en los cuales el ancho de la ranura exterior (7) es mayor que el espesor de los nervios interiores (6). El cierre formando por medio de los nervios (5,6) y las ranuras (7,8) está preferente y completamente dentro de la anchura de la cinta.
Patent FI-20010001-A (FI)
Inventor: AHMAVAARA KALLE
IPC: H04W24/02
Filed: 2001-01-02
Abstract: The invention concerns a method for performing an optimisation of a transmission link in a situation where a mobile terminal has moved from its region in a network controlled by a first radio network control unit RNC1 to a region in the network controlled by a second radio network control unit RNC2. The signalling involved in the method is carried out between the two radio network control units and a mobile telephone exchange MSC. The mobile terminal does not need to take part in the signalling, since the radio resources used remain unchanged. The purpose of the method is to optimise the utilisation of the transmission links in the radio access network RAN which is used and to minimise the transmission delay between the controlling radio network control unit and the radio interface. This is done by relocating of the units which are controlling the connection of a mobile terminal from the first radio network control unit to the second radio network control unit and by optimising the transmission links between the mobile telephone exchange and the second radio network control unit. Such control units can contain, for example, macrodiversity combination functions, radio resource control units, and connected user units. <IMAGE>
Patent FI-20031342-A (FI)
Inventor: VAEHAEKANGAS AATOS
IPC: B22D41/02
Filed: 2003-09-18
Abstract: A method of lining a metallurgical vessel by installing a lining material into the space (9) between a form (8) and the inner wall of the vessel (7) is characterized in that a screw conveyor device (3a, 5a; 3b, 5b) is placed above the space (9), which is left upwards open, to extend along the space in the close vicinity to it, the bottom wall of the screw conveyor device is provided with one or more openings (6a, 6b) extending essentially on the whole length of it, and lining material is brought into the screw conveyor device in which it is transferred and at the same time fed through said openings on essentially the whole length of it into said space (9). The invention concerns also a corresponding device.
Patent FR-1577509-A (FR)
IPC: B29C43/30
Filed: 1968-05-10
Granted: 1969-08-08
Abstract: 1,204,986. Laminates. A. TRICOLLET. 9 May, 1969 [10 May, 1968], No. 23717/69. Heading B5N. A method for the continuous manufacture of a multi-layer strip for use as packaging material includes the steps of printing the upper face of a top layer strip material, corrugating an intermediate layer strip material, uniting the corrugated strip and a backing strip with adhesive and uniting the lower face of the printed top strip by adhesive with the united intermediate and backing strips. A machine for effecting the above process comprises spool holders 1, 2, 3 for supplying the strip materials 4, 5, 6, a helis printing machine 13 having a printing unit 14 and dryer 15 for printing the upper face of strip 4 which is supplied via a tension-controlling assembly 7-11 and guiding device 12, a corrugator 18 for strip 5, a first gumming device 19 for uniting the corrugated strip and backing strip 6 and a second gumming device 16 for uniting the printed top strip with the combined intermediate and backing strips. Union of the layers is synchronized by means of photo-electric cells 20, 21 liaising with automatic tele-controls acting directly on a speedadjusting means of the guiding device 12. The multi-layer strip may pass through a cutter 23 and divider 24. The layers may be of paper.
Patent GB-1054910-A (GB)
IPC: B65D25/10
Abstract: 1,054,910. Package for ampoules. SOCIETE PARISIENNE D'EXPANSION CHIMIQUE S.P.E.C.I.A. May 4, 1965 [May 8, 1964], No. 18800/65. Heading B8P. A package for ampoules has partitions 2 which define juxtaposed compartments, each compartment having a pair of lugs 3, Fig. 4 (not shown), with an inwardly facing portion which serves to hold the ampoules in the package. Supporting chocks 4, Fig. 1, are provided also to support the ampoules. The package may be adapted to house a sinuous object 6, Fig. 5 (not shown). The package is preferably of plastics, e.g. polystyrene, vinyl acetate, vinyl chloride, polyolefins, polyethylene and the polyamides. The packages can be closed by inserting them in cardboard shells 7, Fig. 2 (not shown), or by means of a preferably transparent lid.
Patent GB-1225243-A (GB)
IPC: B26B13/28
Filed: 1967-05-17
Abstract: 1,225,243. Pivot pin. WARD & PAYNE Ltd. 15 May, 1968 [17 May, 1967], No. 22910/ 67. Heading E2F. A pivot assembly comprises a pivot pin 10 having a head 11 and a shank having a bearing surface 14, for insertion through complementary apertures of members to be pivotally connected, and a non-round extension 16, a washer or nut 20 having an aperture of non-round outline and securing means, e.g. screw 24, for holding the washer or nut on the extension thus pivotally connecting the two members.
Patent GB-1225728-A (GB)
IPC: E04D5/10
Filed: 1969-05-20
Abstract: 1,225,728. Seaming non-metallic sheet material. FARMILOE SEALANTS Ltd. 20 May, 1969, No. 25725/69. Addition to 1,187,773. Headings B5K and B5N. [Also in Division E1] A waterproof covering as claimed in claim 1 of parent Specification, is provided with a release strip 23 having an outer layer of rubber or synthetic rubber or synthetic plastics material which has been fully cured and an inner layer of rubber or synthetic rubber or synthetic plastics material which is uncured or only partially cured so that it presents a slightly tacky surface, a strip being placed under each upstanding joint between the adjacent sheets, the sheets and strip being pressed together with the inner layers in contact at each joint. Before being pressed together, the edges of the sheets 15, 18 and the inner layer of the strip 23 are moistened with " white spirit." The layers of the sheets may be made of the materials specified in the parent Specification. Each upstanding joint is provided with a slit 24, Fig. 3, and the end section is turned down as a tab 25 and adhesively bonded to the surface of the sheet 18.
Patent GB-1226697-A (GB)
IPC: G01R22/00
Filed: 1969-10-13
Abstract: 1,226,697. 697. Energy measurement. LANDIS & GYR A.G. Oct.13, 1969 [Oct.18, 1968], No. 50256/69. Heading G1U. A circuit arrangement for measuring electrical energy (in a power network 1) incorporates a mark space modulator 4, which in use is controlled by the voltage in the network 1 to provide an output signal which controls a selector switch 5 to determine at the output of the switch the polarity of a current proportional signal applied to the input thereof. The input to the switch is formed by a current transformer 3 in response to the current in the network 1, so that the mean value in time of the signal at the output of the selector switch is proportional to the product of the voltage and current in the network. The output signal is supplied to a current frequency converter 11 including an operational amplifier 12, which delivers a series of pulses whose frequency is proportional to the product, for subsequent counting at 18. The selector switch 5 may be two pole, as shown in Fig. 1, or the circuit between the current transformer 3 and the operational amplifier 12 may be adapted to operate with a single pole switch by using a centre, tapped transformer Fig. 2 (not shown) or operating on alternate half cycles Fig. 3 (not shown). The selector switch may be formed from field effect transistors controlled by the pulses from the mark-space modulator Fig. 4, (not shown).
Patent GB-1227166-A (GB)
IPC: C09C1/00
Filed: 1968-07-15
Abstract: 1,227,166. Black Fe-Cr oxide pigment. FARBENFABRIKEN BAYER A.G. 15 July, 1968 [13 July, 1967], No. 33604/68. Heading ClM. A black enamel and ceramic colouring substance has a corundum structure and a molar composition substantially according to the following formula: Fe 2 O 3 .(0À7-1À0)Cr 2 O 3  and a particle size of from 0À1 to 60 microns. The X-ray powder exposure with Cr radiation, 2.2909 A, has the following intensive d-values in Angstrom units:-3À65, 2À65, 2À2, 1À85, 1À7, 1À5, 1À45, 1À3, 1À25. It is prepared by annealing at a temperature of from 1000 to 1300 C. a mixture of oxides and/or oxide-forming compounds of iron, chromium, sodium and phosphorus, which contains, per gram-atom of iron, the following constituents: 0À7 to 1.0 gram-atom of Cr, 0À005 to 0.2 gram-atom of sodium, 0.005 to 0.05 gramatom of phosphorus, and grinding, washing and drying the resulting annealed material. The oxide forming compounds may be heat-decomposable hydroxides, acids or salts of Fe, Cr, Na and P such as iron hydroxides, iron sulphates, iron phosphates, iron chromates, chromium hydroxides, chromic acid; ammonium chromate, sodium chromates, chromium sulphate, chromium phosphates, sodium hydroxide, sodium carbonate, sodium nitrite, sodium nitrate, sodium chloride, sodium phosphates, phosphoric acid or any mixture thereof. Can be used with clouding agents such as oxides of zirconium or antimony or of zirconium silicate to give grey enamels and glazings.
Patent GB-1228895-A (GB)
IPC: G01B3/10
Filed: 1968-09-23
Abstract: 1,228,895. Tape measures. QUENOT & CIE S.A.R.L. Sept.23, 1968 [Feb.12, 1968], No. 45100/86. Heading G1M. A tape measure, Fig. 1, comprises a window 5 accommodating a magnifying lens, the back of which lens is arranged to be parallel to the tape. Several shapes of lenses are described and shown.
Patent GB-1230644-A (GB)
IPC: C09D5/25
Filed: 1968-02-20
Abstract: 1,230,644. Polyvinyl acetal/phenolic resin composition. STERLING MOULDING MATERIALS Ltd. 20 May, 1969 [20 Feb., 1968], No. 8303/68. Headings C3P and C3R. A composition comprises a polyvinyl acetal resin, a soluble heat-hardenable phenol aldehyde resin in which a part of the phenol is an arylalkyl phenol, and a volatile inert organic solvent for the resins. The arylalkyl phenol is preferably the reaction product of phenol with styrene. In the examples 45 parts of styrenated phenol, 135 parts of phenol, 100 parts of formalin and 53 parts of triethanolamine are polymerized and 100 parts of a 50% solution in cresylic acid of the phenolic resin produced are added to 100 parts of a solid polyvinylacetal resin, prepared by replacing 95% of the acetyl groups of a polyvinyl acetate with hydroxy groups followed by replacing the hydroxy groups with formaldehyde, and 25 parts of a styrenated phenol in 450 parts of solvent naphtha and after stirring at 38‹ C. 0.5 part of hexamine is added as a catalyst.
Patent GB-1232200-A (GB)
IPC: G05D23/275
Filed: 1969-08-26
Abstract: 1,232,200. Control of A.C. motors. CUTLERHAMMER Inc. 26 Aug., 1969 [26 Aug., 1968], No. 42378/69. Heading H2J. [Also in Division G3] In an arrangement for co-ordinating control of a cooling fan motor and a refrigeration compressor, within a given range the fan motor speed is decreased in correspondance with temperature drop until a point is reached then the compressor is disconnected. A further decrease in temperature decreases the fan motor speed until at the bottom of the range the fan motor is disconnected. A small rise in temperature re-energizes the fan at low speed, and over part of the range the fan speed is increased as the temperature increases. At the top of the temperature range the compressor motor is reenergized coupled with an increase of fan speed. A permanently connected split phase motor 18 is controlled through contacts 82 and also by a triac 86 the gate of which is connected to breakdown diode 92 to a R.C. network C2, 90, 94 and rheostat 96, which is varied by a diaphragm unit 26 also operating contacts 82 and a compressor motor switch (24), see Fig. 1 (not shown) at the bottom of the temperature range. In an alternative arrangement, Fig. 7 (not shown) one motor winding is connected directly across the supply and in another arrangement the shunt between terminals B, C is replaced by a two-way switch which in one position connects the triac gate to a manually variable resistor. The components may be mounted on a printed circuit board and the contacts and the rheostat are operated by a known bellows unit sensitive to a room temperature.
Patent GB-1232915-A (GB)
IPC: E21C25/10
Filed: 1969-03-19
Abstract: 1,232,915. Cutter drums. AUSTIN HOY & CO. Ltd. 18 March, 1970 [19 March, 1969], No. 14535/69. Heading E1F. A cutter drum has shearer cutters 3 and clearance cutters 5 and a carrier 9 rotatable with and displaceable axially of the drum and carrying sumping cutters 13. The carrier has arms 11 slidably received in slots in the drum and in its retracted position a beam 10 of the carrier is disposed in a slot 7; it is moved by a hydraulic ram 12. When extended the carrier is adapted to cut a recess of a depth equal to the drum width, cuttings being removed through an aperture 15.
Patent GB-1252058-A (GB)
IPC: B62D55/24
Filed: 1969-10-16
Abstract: 1,252,058. Endless tracks. E. M. COMELLAS. 16 Oct., 1969 [30 Oct., 1968], No. 50811/69. Heading B7H. A track for endless track vehicles comprises a plurality of articulated ground-engagement elements 1, 2 of which some form wheel guides, the latter elements 2 each having an inclined guide surface 14 for co-operation with the vehicle wheels to cause substantially frictionless lateral guidance of the track relative to the wheels the ground-engaging elements being arranged in a plurality of rows, the elements of any one row being longitudinally staggered relative to those in an adjacent row. The lower surface of each element 1, 2 comprises a concave portion defining, at the ends of the element, ground-engagement traction lugs, e.g. lugs 5 (Fig. 2). The upper ends of each element are cut away, as at 4, to permit the passage of the elements over drive sprockets. The ridge 15 extending along each element to define the inclined surface 14 incorporates a stiffener 18. The elements 1, 2 may be of rubber or plastics and rows of the same may be arranged to provide for guidance of several different types of vehicle wheels (Figs. 4-12, not shown).
Patent GB-1256857-A (GB)
IPC: H03J7/18
Filed: 1970-07-07
Abstract: 1,256,857. Radio receiving circuits. DUCATI ELETTROTECNICA MICROFARAD S.p.A. 7 July, 1970 [10 July, 1969], No. 32828/70. Heading H3Q. An arrangement for distinguishing between modulated carrier waves with different types of modulation, i.e. A.M. and F.M., comprises input terminal 1 and output terminal 4, Fig. 2, between which are two parallel paths comprising (1) a capacitor 5 in series with a switch 15 and (2) a switch 18 which may have in series with it a resistor 17. Alternatively, the second path may comprise two resistors (9, 10) in series, a switch (16) connecting their common point to earth (Fig. 3, not shown). The arrangement is intended for use in a stop on signal television receiver, the output from an A.M. detector fed from a narrow band I.F. filter being applied to terminal 1, and the tuning arresting means coupled to terminal 4. With switch 15 closed and switch 18 capacitor 5 will pass only A.C. from terminal 1 to terminal 4, so that tuning is not arrested upon interception of the frequencymodulated sound carrier, but only on interception of a video carrier, the A.M. modulation of which e.g. the frame signals is passed by capacitor 5. Upon interruption of the tuning scan, switch 18 is closed and switch 15 opened, the tuning of the receiver being held by the D.C. component of the demodulated video carrier, even though the A.C. modulation should momentarily cease. The switches 15, 18 may be operated manually or automatically; in an embodiment of the latter kind, a control signal is applied upon cessation of signal scanning, via terminal 3, Fig. 1, to the base of a transistor Tr3. In the absence of a Control signal transistor Tr3 is non-conductive so that transistors Tr1, Tr2 are biased conductive: transistor Tr1 closes the path between terminals 1, 4 via capacitor 5, while transistor Tr2 effectively opens the path via resistors 9, 10. Upon a control signal being applied to terminal 3, transistor Tr3 becomes conductive, rendering transistors Tr1, Tr2 non-conductive. Capacitor 6 and resistor 7 provide a shorter time-constant than capacitor 11 and resistor 12, so that the path via resistors 9, 10 is completed before the path via capacitor 5 is opened.
Patent GB-1258098-A (GB)
IPC: G06K7/04
Filed: 1969-05-14
Abstract: 1,258,098. Card readers. BODENSEEWERK PERKIN-ELMER & CO. G.m.b.H. 14 May, 1969 [18 May, 1968], No. 24669/69. Heading G4M. Cards 12 carried on a turntable of automatic chemical analysis apparatus are sensed in motion by an array of pins 56 mounted on a carriage 22 which is driven towards a card 12 by a motor when a pin 14 on the turntable engages a lever 32 to cause corresponding movement of a carriage 16 parallel to movement of the card 12 by way of linkage 30, 28. Projections 58, 60 on the sensing-head engage the card support to centre the head with respect to the card. An additional row of pins 56 may be provided to detect incorrect positioning of the card. A perforated drum 66 rotated at the same time as carriage advancing cam 52 may have associated photo-cells 72 to produce pulse trains which are supplied to pins 56, whereby the total number of output pulses from the pin contacts 64 represents the value punched on the card.
Patent GB-1258244-A (GB)
IPC: G03G5/06
Filed: 1968-06-10
Abstract: 1,258,244. Electrophotographic material. AGFA-GEVAERT N.V. 22 May, 1969 [10 June, 1968], No. 27525/68. Heading H1K. An electrophotographic material comprises a layer or sheet containing an organic photoconductor and a compound comprising one or more electron-withdrawing groups and corresponding to one of the following general formulae wherein R 1 , R 2 , R 3  and R 4  are H, halogen, NO 2 , CN, CO 2 H, carbamoyl or aryl including substituted aryl or R 1  together with R 2  and R 3  together with R 4  represent the atoms necessary to complete a fused-on aromatic nuclei and Y -stands for CH 2  or CN 2 . The photoconductor is preferably polyvinyl carbazole or p-(4,5-dihydro-1,3-diphenyl-5-pyrazolyl)-phenol. A polymeric binder such as copoly vinyl acetate-vinyl chloridemaleic anhydride may be used. Other polymeric binders and plasticizers are specified. The layer may be formed on a sheet or foil of Al, Cu, Ni, Ag, Fe, Zn, Sn or Pb, carbon particles in gelatine, Al/paper laminate or a conductive polymer layer.