baber/WOPTO huggingface dataset:
Patent BR-112023000489-A2 (BR)
Title: Análogos de camptotecina conjugados a um resíduo de glutamina em uma proteína, e seu uso
Inventor: Amy han
IPC: A61P35/00
Filed: 2021-07-12
Abstract: ANÁLOGOS DE CAMPTOTECINA CONJUGADOS A UM RESÍDUO DE GLUTAMINA EM UMA PROTEÍNA, E SEU USO. São descritos nesse documento conjugados de proteína-fármaco e composições dos mesmos que são úteis, por exemplo, para dispensação específica de alvo de frações terapêuticas, por exemplo, análogos e/ou derivados de camptotecina. Em certas modalidades, são fornecidos métodos específicos e eficientes para a produção de construtos de proteína-fármaco (por exemplo, conjugados de anticorpo-fármaco) utilizando uma combinação de técnicas de transglutaminase e 1,3-cicloadição. São fornecidos análogos de camptotecina, conjugados de anticorpo-fármaco e composições que compreendem anticorpos modificados por glutaminil e cargas úteis de análogos de camptotecina.
Patent BR-112023002849-A2 (BR)
Title: Dispositivo para injetar um gás redutor em um forno de cuba
Inventor: EDOUARD IZARD
IPC: F27D3/16
Filed: 2020-09-15
Abstract: DISPOSITIVO PARA INJETAR UM GÁS REDUTOR EM UM FORNO DE CUBA. Dispositivo para injetar um gás redutor em um forno de cuba compreendendo um invólucro externo cuja face frontal é provida de uma saída para injeção de gás no forno de cuba, um invólucro interno localizado no interior do invólucro externo e feito de um aço capaz de resistir a uma temperatura de até 1200ºC, tendo este invólucro interno uma abertura correspondente à saída de injeção de gás da face frontal do invólucro externo e uma camada refratária localizada entre o invólucro externo e o invólucro interno.
Patent BR-112023016122-A2 (BR)
Title: Instalações e conjuntos de válvula de conduto de limpeza
Inventor: DAVID A PUTNAM
IPC: E02D29/14
Filed: 2022-02-09
Abstract: instalações e conjuntos de válvula de conduto de limpeza. um alojamento de limpeza tendo um interior e para colocação em um furo de conduto de limpeza com pelo menos um conduto de limpeza se estendendo para o interior de alojamento de limpeza. uma porta de alojamento de limpeza pode ser disposta em uma abertura de alojamento de limpeza. pelo menos um conjunto de válvula de conduto de limpeza pode ser configurado para ser disposto em comunicação fluida com o pelo menos um conduto de limpeza no interior de alojamento de limpeza. o pelo menos um conjunto de válvula de conduto de limpeza inclui um alojamento de válvula para montagem no conduto de limpeza. uma montagem de válvula pode ser suportada pelo alojamento de válvula e incluir um braço de válvula suportado articuladamente pela montagem de válvula. um batente de válvula pode se estender a partir do braço de válvula. um corpo de válvula pode ser suportado pelo braço de válvula e está posicionado entre uma posição fechada e aberta. o batente de válvula engata no corpo de válvula na posição aberta.
Patent CS-73192-A3 (CS)
Title: Barrel with a plastic bung
Inventor: SCHUTZ UDO
IPC: B65D8/02
Filed: 1992-03-11
Abstract: A filling and emptying bung (9) and an aerating and venting bung (10) are arranged in a protected manner in depressions (11, 12) in the lid part (4) of the barrel. The stacking surface (8) of the lid part (4) merges into two webs (17, 18) which run in the circumferential direction, include the bottom surface of the depression (11) for the filling and emptying bung (9), run with a slight gradient from the stacking surface (8) to the bottom surface of the depression (11) and, in a slightly tilted inverted position (1') of the barrel, form drainage channels (21, 22) for the residual liquid (24) which collects on the inside (27) of the lid part (4) and drains through the bung hole (15) of the filling and emptying bung (9). <IMAGE>
Patent CZ-14194-A3 (CZ)
Title: The use of urea derivatives, and process for preparing thereof
Inventor: HACKL KURT ALFRED DR DIPL ING
IPC: C07D295/08
Filed: 1994-01-21
Abstract: Use of ureas in which at least one of the two nitrogen atoms of the urea is part of a non-aromatic ring which can be interrupted by an oxygen or sulphur atom, as a chemical solvent, and a process for the preparation of tri- or tetraalkylated ureas or diureas, at least one of the nitrogen atoms of the urea being part of a non-aromatic ring which can be interrupted by an oxygen or sulphur atom, by dialkylation of the -NH2 group of a urea with an alkylene- or alkylenearylenealkylene dihalide, disulphonate or dihydrogensulphate in the presence of a solid base and of a phase-transfer catalyst.
Patent CZ-80494-A3 (CZ)
Title: Bread-crumbs for foodstuff articles intended for heat treatment and process for producing such bread-crumbs
Inventor: BROBERG LARS
IPC: A23L13/00
Filed: 1994-04-06
Abstract: A breadcrumb coating for food products which are to be cooked in the oven comprises cereal crumbs, a source of reducing sugars and more than 7% by weight of fats, preferably from 8 to 12% by weight. It is obtained by cooking and extruding the mixture of starting ingredients, grinding and finally drying the ground product.
Patent SK-27598-A3 (SK)
Title: Piperazine derivatives and process for the preparation thereof
Inventor: CHO EUI-HWAN
IPC: C07D295/215
Filed: 1997-06-28
Abstract: PCT No. PCT/KR97/00128 Sec. 371 Date Feb. 27, 1998 Sec. 102(e) Date Feb. 27, 1998 PCT Filed Jun. 28, 1997 PCT Pub. No. WO98/00402 PCT Pub. Date Jan. 8, 1998The present invention relates to novel compound having strong antimumor activities of the general formula(I) wherein R1 and R2 are independently hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C2-C8 unsaturated alkyl, ketone, substituted or unsubstituted aryl, substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted arylhydroxy, substituted or unsubstituted amino, C1-C4 lower ester, C1-C4 lower thioester, thiol, substituted or unsubstituted carboxyl, epoxy, substituted or unsubstituted C1-C4 lower thioalkoxy; or R1 and R2 are fused to form C3-C4 saturated or unsaturated chain; R3, R4, R5, R6 and R7 are independently hydrogen, halogen, hydroxy, nitro, C1-C4 lower ester, C1-C4 lower alkyl, C1-C4 lower thioalkyl, substituted or unsubstituted C3-C6 cycloalkyl, C1-C4 lower alkoxy, C1-C4 lower thioalkoxy, substituted or unsubstituted aryl, substituted or unsubstituted lower arylalkoxy, substituted or unsubstituted lower alkylamino, or lower alkyl substituted or unsubstituted carbamate; or among R3, R4, R5, R6 and R7, two adjacent groups are bonded with each other to form 1,2-phenylene or 2,3-naphthylene; X is oxygen, sulfur, or substituted or unsubstituted imino; Y is bonded at the 3-position or 4-position of the aromatic ring part wherein Y is oxygen or -NR8- (wherein, R8 is the same with the above-mentioned R3.); Z is hydroxy, C1-C4 lower alkoxy, C1-C4 lower thioalkoxy, substituted or unsubstituted aryloxy, C1-C4 lower alkylamino, substituted or unsubstituted cycloamino containing 1-5 nitrogen atoms; A is nitrogen or -CH=; its pharmaceutically acceptable acid addition salts and process for the preparation thereof.
Patent SK-32798-A3 (SK)
Title: Pharmaceutical combination preparations containing erythropoietin and iron preparations
Inventor: LEHMANN PAUL
IPC: A61K38/18
Filed: 1996-09-12
Abstract: The present invention relates to a pharmaceutical combination preparation comprising 2,000 - 7,000 U of recombinant human erythropoietin (EPO) and 5 - 20 mg of one Fe(III)-complex, it being possible to have the rhEPO and the Fe(III)-complex in separate forms of administration or in a uniform form of administration. The pharmaceutical preparation is used to treat anaemias or haemodialysis patients.
Patent SK-64699-A3 (SK)
Title: Ear tag applicator
Inventor: GARDNER MICHAEL STUART
IPC: A01K11/00
Filed: 1997-11-13
Abstract: An animal ear tag applicator (1) has a jaw (2) with a pivotal pin (7) which can hold the male part (50) of an animal ear tag and engage it with the female part (51) of the tag held in the lower jaw (3). The jaw (2) is biased by spring (16) to open independently of the handles (4, 5) once the latch (30) has been released. This will only occur after the male and female parts of the tag have been fully engaged. This independent release of the jaw (2) and the ability of the pin (7) to pivot forwardly avoids jamming of the ear tag in the applicator (1), especially when the animal attempts to pull away. The applicator can also be used with single piece tags.
Patent CH-633148G-A3 (CH)
IPC: G04C9/00
Filed: 1979-04-19
Abstract: The setting mechanism of a watch includes a winding stem and a clutch wheel which can be moved selectively either rotationally or axially by said winding stem for control of one or more setting levers or wheels. The setting levers or wheels are disposed on the opposite side of said winding stem from the dial plate of the watch, thereby making it possible to center the winding stem in the thickness direction of the watch and to reduce the over-all thickness of the watch.
Patent CS-138591-A3 (CS)
Title: Piperidyloxy- and quinuclidinyloxyisoxazole derivatives, process of their preparation and use
Inventor: NAGANO MITSUO
IPC: C07D261/12
Filed: 1991-05-10
Abstract: Compounds of formula (I): <CHEM> [in which: R<1> is hydrogen, halogen or alkyl; R<2> is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R<1> and R<2> together form a group of formula -CR<4>=CR<5>-CR<6>=CR<7>-, where R<4>, R<5>, R<6> and R<7> are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R<3> is piperidyl, substituted piperidyl or quinuclidinyl] are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.
Patent CZ-254692-A3 (CZ)
Title: Rubber compositions with reduced coloring and decoloring powers
Inventor: VANDEVELDE OSCAR GHISLAIN JOSE
IPC: C08L21/00
Filed: 1992-08-19
Abstract: Rubber compositions are described having desirable properties inclusive of reduced stain and discoloration. The compositions contain in addition to rubber and conventional additives a low level of specific N,N-disubstituted alkoxyanilines and are most preferably substantially free of phenylene diamine anti-ozonants.
Patent CZ-256692-A3 (CZ)
Title: BENZO(f)QUINOLINE, PROCESS OF ITS PREPARATION AND A PHARMACEUTICAL COMPOSITION IN WHICH IT IS COMPRISED
Inventor: AUDIA JAMES EDMUND
IPC: A61P17/14
Filed: 1992-08-20
Abstract: This invention relates to hexa- and octahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds and methods of their use as steroid 5 alpha reductase inhibitors.
Patent CZ-615590-A3 (CZ)
Inventor: RATAJ JAROMIR
IPC: E06B3/46
Filed: 1990-12-11
Abstract: Dřevěné okno s horizontálně posuvnými křídly jevy tvořeno z pevného rámu (1) okna z dřevěné profilové lišty (la), z vnějšího okenního křídla (2) a z vnitřního okenního křídla (3), vytvořených z dřevěné profilové lišty (5), v kombinaci s profilovými lištami (4,6,7) z plastické hmoty, připojenými k rámu (1) okna a rámům okenních křídel (2,3) tak, že části profilových lišt (4,6,7) z plastické hmoty překrývají z vnější strany po obvodě dřevěné části jak rámu (1) okna, tak i rámů okenních křídel (2,3).
Patent CZ-130494-A3 (CZ)
Title: Mortise dead lock
Inventor: EGRESITS ARPAD
IPC: E05B23/00
Filed: 1994-05-27
Abstract: The invention concerns a lock bolt mechanism actuable by a two-bit key (12) which can be placed into a rebate chiselled out for this purpose in a door, which has a lock casing accommodating a bolt head which is pushed out on closure, tumblers (10) fitting to the notches of the two-bit key which together with tumbler supporting springs (13) are threaded on to a common tumbler pin (11) for assuring a two-stage locking, as well as a spring-supporting pin (9) furthermore a guide pin (4) fixed into the lock casing for assuring the locking of the tumblers, and wherein on one side of the bolt head (8) there is a lower bolt body plate (6) and on the other side of the bolt head (8) there is an upper bolt body plate (7), the plates being fixed together by way of the spring-supporting pin (9) and which are fixed to the bolt head (8) by way of permanent connecting element(s) (15), further in that of the lower bolt body plate (6) and the upper bolt body plate (7) at least one, but preferably both, is/are formed with a first bolt tooth (7a) corresponding to the first stage of locking and the second bolt tooth (7b) corresponding to the second stage of locking. <IMAGE>
Patent CZ-142097-A3 (CZ)
Title: Container lock
Inventor: SAMUELSON BJORN
IPC: B65D90/00
Filed: 1995-11-10
Abstract: A container locking device (1, 2, 3, 4, 5, 6, 7) of twistlock type having upper and lower connectors (2, 3) on a common shaft (7) rotatably arranged in a housing (1), the lower connector (3) providing a movable latch nose (3; 33). The locking device allows for a straight vertical put-down and locking during loading of a container, and automatic release thereof at the non-accessible container end of a container stack. Secured locking with decreased vertical clearance is achieved.
Patent CZ-173498-A3 (CZ)
Title: Intelligent charging alternator
Inventor: DURELLI OLINDO LUCA JULIO
IPC: H02K47/02
Filed: 1998-06-05
Abstract: The arrangement has a stator, a rotor and winding arrangements, especially in a three-phase, single-phase triangular or star structure. The winding arrangements are individually associated with rectifier arrangements. The one or more winding arrangements can be arranged in a groove in the stator. Several winding arrangements mounted in a groove in the stator can have the same winding number. A battery to be charged can be connected to each winding arrangement.
Patent CZ-193894-A3 (CZ)
Title: Removing of lignin by oxygen from waste cellulose and paper products
Inventor: NGUYEN XUAN TRUONG
IPC: D21C5/02
Filed: 1993-02-17
Abstract: Waste cellulosic paper products, for example, old corrugated container are recycled employing oxygen delignification in the presence of an alkaline material to produce a recycled pulp of lower kappa number, while maintaining adequate strength in the pulp. The recycling process preferably employs an acid pretreatment in combination with the oxygen delignification, and exposure of the waste product to the alkaline material is preferably controlled so that at any point in the delignification the waste product is exposed to not more than 50%, by dry weight, of the alkaline material based on the weight of residual lignin in the waste paper product.
Patent CZ-201076-A3 (CZ)
Inventor: ECERBA MAREK
IPC: G08G1/09
Filed: 2010-02-01
Abstract: Telematické zarízení pro zvýšení bezpecnosti silnicního provozu, zejména pri pohybu vozidel (3) údržby a/nebo integrovaného záchranného systému na rychlostních komunikacích, zahrnuje promenná dopravní znacení (4), umístená u rychlostní komunikace v odstupu pred kritickým místem v silnicním provozu, která jsou ovladatelná dálkovým spínacem (5) uloženým ve vozidle (3) údržby a/nebo integrovaného záchranného systému. Dálkový spínac (5) promenných dopravních znacení je vytvoren pro spínání promenných dopravních znacení kódovaným radiovým signálem. Kritickým místem v silnicním provozu je místo pro otácení vozidel (3) údržby a/nebo integrovaného záchranného systému na dálnicích (1) a/nebo rychlostních komunikacích. Promenné dopravní znacení (4) je zpravidla umísteno ve dvou vzdálenostech pred i za kritickým místem v silnicním provozu, a to zpravidla v odstupu asi 300 metru a asi 600 metru pred i za kritickým místem v silnicním provozu.
Patent CZ-230297-A3 (CZ)
Title: Granulation product as an oral dosing form of beta-lactam antibiotics, process for preparing thereof, as well as the oral dosing form and process of its preparation
Inventor: SIJBRANDS GERRIT JAN
IPC: A61K9/00
Filed: 1996-02-08
Abstract: PCT No. PCT/EP96/00547 Sec. 371 Date Aug. 6, 1997 Sec. 102(e) Date Aug. 6, 1997 PCT Filed Feb. 8, 1996 PCT Pub. No. WO96/24337 PCT Pub. Date Aug. 15, 1996A granulate, containing at least 50 wt. % of a water soluble  beta -lactam antibiotic, is provided. A process to prepare a granulate containing such  beta -lactam antibiotic comprises moistening components making up the granulate with an aqueous solution containing no substantial amount of a wet granulation binding agent. Oral dosage-forms, which contain the said antibiotic in a granular form, a cellulose product and a disintegrant and which quickly disperse when placed in an aqueous environment, are disclosed, as well as a method for the preparation of the dosage-forms.
Patent CZ-247995-A3 (CZ)
Inventor: KOKES JOSEF DOC ING CSC
IPC: H04N1/21
Filed: 1995-09-25
Abstract: Zařízení ke zpracování dokumentů je tvořeno
reprodukčním sběračem, který sestává ze snímacího
zařízení, tvořeného snímací optikou
snímacího členu s osvětlením a integrální počítačovou
jednotkou s příslušenstvím pro digitalizaci
snímaných dat, kde ke vstupu snímacího
zařízení je přiřazeno tiskací zařízení,
přičemž výstup snímacího zařízení je spojen s
komprimačním zařízením digitalizovaných
dat.
Patent CZ-276395-A3 (CZ)
Title: DERIVATIVES OF BENZO(f)QUINOXALINEDIONE, PROCESS OF THEIR PREPARATION AND USE IN MEDICAMENTS
Inventor: HOLSCHER PETER
IPC: A61P25/00
Filed: 1994-04-28
Abstract: PCT No. PCT/DE94/00495 Sec. 371 Date Jan. 22, 1996 Sec. 102(e) Date Jan. 22, 1996 PCT Filed Apr. 28, 1994 PCT Pub. No. WO94/25470 PCT Pub. Date Nov. 10, 1994Compounds of formula I    <IMAGE>  (I)  are described, in which substituents R1-R4 have the meanings mentioned in the application as well as their production and use in pharmaceutical agents.
Patent CZ-278498-A3 (CZ)
Title: Process of covalent modification of surfaces by making use of polymers in order to increase biological compatibility
Inventor: WAGNER WILLIAM R
IPC: A61L33/00
Filed: 1997-03-07
Abstract: Described herein is a technique for covalently modifying tissue and cellular surfaces to inhibit cell adhesion. The process described herein is conducted under conditions tolerable in vivo and employs a biocompatible polymer having a reactive group attached to at least one end that reacts with groups present or on tissue and cellular surfaces under aqueous and mild conditions and thereby covalently attaches the polymer to the tissue or cellular surface. Preferably, the reactive group attached to the polymer reacts with amines and hydroxyls present on tissue and cellular surfaces. In one preferred embodiment, the methods described herein provide for the covalent modification of tissue and cellular surfaces using a PEG-diisocyanate solution. The methods described herein are particularly useful in impairing platelet and leukocyte deposition in blood vessels and thereby thwarting thrombosis and restenosis, a common complication of vascular procedures including PTCA and vascular surgery. Furthermore, by masking the tissue surface proteins from blood elements, the methods described herein are useful in decreasing graft thrombogenicity and reducing the complications of vascular surgery. Finally the methods described herein reduce the immunogenicity of transplanted tissues and cells and thereby reduce the need for immunosuppressive therapy.
Patent CZ-282796-A3 (CZ)
Title: Epoxyamine barrier coatings
Inventor: CARLBLOM LELAND H
IPC: C08J7/04
Filed: 1995-02-07
Abstract: Polyepoxide-polyamine gas barrier coatings for use on packaging materials such as polymeric containers are provided with more stable low permeability at high humidity conditions by including high aromatic content in systems cured with a substantial excess of polyamine. The polyamine is an adduct of a polyamine having high aromatic content reacted with epichlorohydrin, certain polyepoxides, novolac epoxy resin, bisphenof F epoxy resin, or formaldehyde/phenol Mannich bases. The polyamine adduct is cured with polyepoxide which also may have aromatic content, with the exclusion of bisphenol A epoxy resins.
Patent CZ-291499-A3 (CZ)
Title: Preparations for treating ARDS or IRDS containing 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and pulmonary surface-active agent
Inventor: GERMANN PAUL-GEORG
IPC: A61P11/00
Filed: 1998-02-14
Abstract: Composition for the treatment of infant or adult respiratory distress syndrome (IRDS and ARDS) contains N-(3,5-dichloropyrid-4-yl)-3- cyclopropylmethoxy-4- difluoromethoxybenzamide (II) (and/or its salts) and a lung surfactant.
Patent CZ-322598-A3 (CZ)
Title: Treatment process of ammonia alum
Inventor: KREPELKA JAN ING
IPC: B09B3/00
Filed: 1998-10-06
Abstract: The present invention relates to a treatment process of ammonium alum, which process is characterized in that optionally dehydrated ammonium alum is subjected to thermal decomposition by heating thereof to a temperature in the range of 400 to 600 degC for a period of 15 to 180 minute and the thermal decomposition product is then immediately or subsequently dissolved in water with temperature of 40 to 95 degC to give an aqueous solution of aluminium sulfate from which crystalline aluminium sulfate can be optionally isolated.
Patent CZ-326996-A3 (CZ)
Title: Device for liquid manure application
Inventor: FLIEGL JOSEF
IPC: A01C23/00
Filed: 1996-11-07
Abstract: The distributor has distribution tubes (3a,3b) with outlet apertures (5) in their longitudinal direction. The cross-section of the distribution tubes in at least the aperture area, is semi-circular. In this area run rotating delivery devices (6) along the tube, with spaced apart delivery members extending to the tube's inner wall. The free ends of these members, which are ground, can slide along the tube's inner walls. The delivery devices are formed as augers and operable by a drive motor (7).
Patent CZ-348397-A3 (CZ)
Title: System for a ridge arranged for roof ventilation
Inventor: KAEMPER JAN
IPC: E04D13/16
Filed: 1997-11-03
Abstract: In order to provide a ventilated roof ridge which is formed from ridge tiles and in which the ridge tiles are laid so as to overlap one another it is proposed that a barrier means (5) which is approximately matched to the cross-sectional shape of the ventilation gap (4) between the tile ends is disposed in front of the ventilation gap (4) or in the opening of the ventilation gap (4), which barrier means has a multiplicity of ventilation openings and in that the ventilation openings are dimensioned smaller in cross section than corresponds to a flight-entry opening for small birds.
Patent CZ-410097-A3 (CZ)
Title: Railway vehicle bogie
Inventor: BIEKER GUIDO DIPL ING
IPC: B61F5/10
Filed: 1994-04-18
Abstract: The invention relates to running gear for rail vehicles in which a running gear frame (2) is carried by the wheels or wheel sets (1) by means of primary springs, and on which the coach body (4) or the coach body (4) of the rail vehicle is directly supported by means of secondary springs (3) via a rocker (5), and the rocker (5) or the coach body (4) is also connected with respect to the running gear frame (2) by means of shock absorbers which damp vertical and rolling movements and at least one rail support (8-10) which absorbs rolling movements and bears fixed levers (9) which are connected to the rocker (5) or to the coach body (4) via pendulum element (10) which are mounted in an articulated fashion. The object of the invention is, with the aim of achieving a maximum possible coach cross-section, to find an inclination device in which, during the rolling of the coach body (4) when there is an excess of centrifugal force, as far as possible the centre of motion lies in the plane of the centre of rolling, which inclination device can be retrofitted on existing running gear, can be used under existing coach bodies (4) and is distinguished by simple constructional elements. This object is achieved in that at least one of the pendulum elements (10) of the roller support consists of an actuator which can be acted on in the opposite direction when one transverse end of the rocker (5) or one side of the coach body (4) dips or rises. <IMAGE>