baber/WOPTO huggingface dataset:
Patent IE-42340-B1 (IE)
Title: 11,12,-secoprostaglandins
IPC: C07D213/70
Filed: 1975-09-03
Abstract: 1477280 11,12-Secoprostaglandins; Grignard intermediate MERCK & CO Inc 3 Sept 1975 [13 Sept 1974] 36310/65 Headings C2C and C2J The invention comprises 11, 12-secoprostaglandins of the Formula I in which R is COOH 1 (C 1-10 alkoxy)carbonyl, CONR3R4 wherein R3 and R4 each are H, C 1-4 alkyl a C 4-2 dialkylamino, or CONHNH 2 ; R1 is H or C 1-4 alkanoyl, R2 is -O-R5 or -S-R5, where R5 is C 1-5 alkyl, fluoro-C 1-9 alkyl, phenyl or benzyl optionally substituted once or twice by halogen, CF 3 , C 1-5 alkyl, C 1-5 alkoxy, dimethylamino, nitro, mesyl or C 1-5 alkanoyl, pyridyl, pyrimidinyl furfuryl, thienyl or methylene dioxyphenyl; A is -CH 2 - or O; and each of Y and Z is ethylene, cis- or trans-vinylene or ethynylene, and salts thereof when R is COOH and their preparation. Compounds of Formula I in which A, Y and Z are ethylene, R is COOH and R1 is H are prepared reacting compound of the formula wherein R 6 is C 1-5 alkyl, with peroxy acids to products epoxides of the formula which are then reacted, in the presence of strong bases, with anions of compounds of the formula R5OH or R5SH, and the resulting esters hydrolysed. Compounds of Formula I in which R is COOH and R1 is H may be obtained by alkylating compounds of the formula with compounds of the formula wherein X is halogen, and hydrolysing the resulting esters. Compounds in which R is other than COOH and/or R1 is alkenoyl are obtained by standard methods from the corresponding compounds in which R is COOH and/or R1 is H. Compounds of Formula I in which Y is may also be prepared by hydrogenating the corresponding compounds in which Y is ethynylene. The following intermediates are also prepared: ethyl 7 - (methanesulphonamido)heptanoate; ethyl 7 - [N - (4 - pentenyl)methanesulphonamido]heptanoate; 4-fluorophenoxyacetaldehyde and the diethyl acetal thereof; 1 - (2 - tetrahydropyranyloxy) - 4 - acetoxy - 5- (4 - fluorophenoxy) - 2 - pentyne; 1 - (2 - tetrahydropyranyloxy) - 4 - acetoxy - 5 - (4 - fluorophenoxy)pentane; 4 - acetoxy - 5 - (4 - fluorophenoxy) - 1 - pentanol, and the p - toluenesulphonate thereof; 4 - acetoxy - 5 - (4 - fluorophenoxy) - 1 - iodopentane; and N - [4 - acetoxy - 5- (4 - fluorophenoxy)pentyl]methanesulphonamide. 3 - (2 - Tetrahydropyranyloxy) - 1 - propynylmagnesium bromide is obtained by reacting 2- (2-propynyloxy)tetrahydropyran with methylmagnesium bromide. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above 11, 12-secoprostaglandins or pharmaceutically acceptable salts thereof together with non-toxic carriers. The compounds may be used for estrus synchronization, treatment of infertility due to persistence of luteal function, and on postcoital contraceptive agents and antithrombotic agents.
Patent IE-50673-B1 (IE)
Title: Hybrid cell line for producing complement-fixing,monoclonal antibody to human supressor t cells,antibody,method of preparation of this antibody,diagnostic and therapeutic uses and pharmaceutical compositions comprising this antibody
IPC: C12N15/00
Filed: 1980-12-03
Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF<sub>1</sub> mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
Patent IE-47704-B1 (IE)
Title: Disposable pilch
IPC: A61F13/15
Filed: 1978-12-28
Abstract: A unitary disposable pilch comprises a waterproof sheet 2 and a waterpermeable sheet 1 enclosing an absorbent pad 3. Two elastic elements e.g. rubber bands are attached to the waterproof sheet adjacent a longitudinal edge of the pad, and spaced from a said edge at least in the crotch portion at a distance between 13 mm and 19 mm. These elements improve the water tightness of the crotch portion.
Patent IE-50831-B1 (IE)
Title: Chewing gum having a soft texture
IPC: A23G4/10
Filed: 1980-12-05
Abstract: A chewing gum is provided which initially has a relatively hard texture making it easy to wrap and which subsequently changes to a relatively soft texture facilitating easy bite through. The above chewing gum includes gum base, corn syrup, solids and one or more liquid moisturizers initially separated from the corn syrup solids, together with optional sweeteners and bulking agents, softeners and the like. A method for preparing the above chewing gum is also provided.
Patent IE-68943-B1 (IE)
Title: Panel heat exchangers
Inventor: MOONEY BRIAN F
IPC: E21B10/00
Filed: 1984-10-22
Abstract: Panel heat exchangers are made by joining heat exchange elements (2) to one another by welds (7) to form a panel (2a), and by then joining headers (1) to one side of the panel (2a) by means of lengthwise welds (8) and end welds (9). The welds (7,8) may be applied automatically. Locating means (5) may be provided to facilitate locating the headers (1) and heat exchangers (2) relative to one another. An aesthetically pleasing panel heat exchanger may be made in an automated or semi-automated manner.
Patent IE-62304-B1 (IE)
Title: Chimeric antibody with specificity to human tumor antigen
Inventor: LIU ALVIN Y
IPC: C07K16/00
Filed: 1987-10-27
Abstract: A chimeric antibody with human constant region and murine variable region, having specificity to a human tumor antigen, methods of production, and uses.
Patent IE-59661-B1 (IE)
Title: Skin moisturizing microemulsions
IPC: A61K8/00
Filed: 1986-11-14
Abstract: The present invention provides microemulsions, containing moisturizing agents or sunscreens, suitable for cosmetic uses. Also disclosed are methods of moisturizing dry skin using the microemulsions containing moisturizing agents. Further, there are provided methods of potentiating the effects of macroemulsion moisturizing creams and lotions by the prior application of the described microemulsions.
Patent IE-76143-B1 (IE)
Title: Novel phenylimidazolidines process for their preparation their use as medicaments and pharmaceutical compositions containing them
Inventor: GAILLARD-KELLY MARTINE
IPC: C07D233/84
Filed: 1992-01-08
Abstract: Products of formula (I): <IMAGE>  in which:     R1 denotes cyano, nitro or halogen,   R2 denotes trifluoromethyl or halogen;  the group -A-B- is chosen from the radicals <IMAGE> in which X denotes oxygen or sulphur and R3 is chosen from:     - a hydrogen< - alkyl, alkenyl, alkynyl, aryl or arylalkyl, optionally substituted;    Y denotes oxygen or sulphur or NH,  with the exception of the products in which:  the group -A-B- denotes the radical <IMAGE> in which X denotes oxygen, R3 denotes hydrogen, Y denotes oxygen or NH, R2 denotes halogen or trifluoromethyl and R1 denotes nitro or halogen; the preparation, their application as medications and especially antiandrogens.
Patent LU-100090-B1 (LU)
Title: Gear transmission type two-hole laser light driving mechanism
Inventor: CHEN YULAN
IPC: H01S5/00
Filed: 2017-02-17
Granted: 2017-06-19
Abstract: The present invention relates to a laser light component, and in particular to a gear transmission type two-hole laser light driving mechanism. The gear transmission type two-hole laser light driving mechanism comprises a mini reduction gearbox (1), wherein the interior of the mini reduction gearbox (1) is provided with two circularly cylindrical light outlet driven gears (2), two intermediate transmission gears (3) and a motor driving gear (4), the light outlet driven gears (2) are meshed with the intermediate transmission gears (3), the intermediate transmission gears (3) are meshed with the motor driving gear (4), and grating adhesion holes (5) nest the upper ends of the light outlet driven gears (2). All key components in the mini reduction gearbox (1) utilize 1:1 gear meshing transmission; without changing the rotation speed of a stepping motor, a dynamic light emission effect is achieved; furthermore, the two grating adhesion holes are utilized, so that the output grating patterns change irregularly and have higher ornamental value; additionally, the components of the driving mechanism replace the traditional metal materials with plastic materials, so that the structure is simple and compact, operation is stable and reliable, the production and maintenance costs are largely reduced, and the practicability is high. Fig. 1
Patent LU-101879-B1 (LU)
Title: Hard disk fixing device with electromagnetic shielding function
Inventor: GU JUNLAN
IPC: G06F1/18
Filed: 2018-11-07
Granted: 2020-07-13
Abstract: The present invention discloses a hard disk fixing device with electromagnetic shielding function, comprising: a box body, a horizontally placed hard disk disposed inside the box body, and a horizontally placed rectangular fixing frame fitted on the hard disk. The fixing frame is fixed to the inner wall of the box body by means of a connecting member. The box body includes an insulating layer, an electromagnetic shielding layer and an outer protection layer that are vertically arranged sequentially from inside to outside. In the hard disk fixing device with electromagnetic shielding function of the present invention, the box body comprises an electromagnetic shielding layer capable of reducing the impact of external electromagnetic radiation on the hard disk, and the box body further comprises an outer protection layer, said layer having corrosion resistance, anti-oxidization, flame retardant, and thermal insulation capabilities, thus being capable of protecting the electromagnetic shielding layer well.
Patent LU-502076-B1 (LU)
Title: Ein heterogen dotiertes flexibles elektrodenmaterial auf der basis von polypyrrolpapier und zubereitungsmethode
Inventor: HAN SHOUYI
IPC: C08L97/00
Filed: 2022-05-11
Granted: 2022-11-17
Abstract: Die vorliegende Erfindung offenbart ein heterogen dotiertes flexibles Elektrodenmaterial auf der Basis von Polypyrrolpapier, wobei die Herstellungsschritte das gleichzeitige Auflösen einer bestimmten Menge von Ligninsulfonat und Natriumanthrachinon-2-sulfonat in einer bestimmten Menge von destilliertem Wasser umfassen, um eine hetero-dotierte Lösung zu erhalten; eine bestimmte Menge Zellulosefasern wird in einer heterogenen Dotierungslösung dispergiert und in ein Eiswasserbad gelegt, nach mechanischer Dispersion wird eine bestimmte Menge Pyrrolmonomer zugegeben, und nach mechanischem Rühren für eine bestimmte Zeit wird die Polymerisation durch tropfenweise Zugabe einer Lösung von Eisenchlorid-Oxidationsmittel eingeleitet; nach einer bestimmten Polymerisationszeit wird das Produkt gefiltert, gewaschen und getrocknet, um ein heterogen dotiertes flexibles Elektrodenmaterial auf der Basis von Polypyrrolpapier zu erhalten. Die Erfindung hat ein einfaches Verfahren, einfache Verfügbarkeit von Rohstoffen, geeignet für die großindustrielle Produktion, und das heterogen dotierte flexible Elektrodenmaterial auf der Basis von Polypyrrolpapier hergestellt hat die Eigenschaften der niedrigen Kosten und hohe spezifische Kapazität.
Patent NO-322974-B1 (NO)
Inventor: STOCKWELL JOHN OLIVER
IPC: D21H23/04
Filed: 1998-09-07
Abstract: PCT No. PCT/GB97/00649 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Mar. 10, 1997 PCT Pub. No. WO97/33041 PCT Pub. Date Sep. 12, 1997Paper making processes, including microparticulate processes, which utilise bentonite are provided with bentonite in the form of a concentrate, or a dilute dispersion made by diluting the concentrate, wherein the concentrate is a dispersion of 15 to 40% by weight bentonite in water containing citrate and has a viscosity below 5000 cps and is a stable fluid. The concentrates are novel. They are preferably made by mixing alkaline earth bentonite with water and sodium citrate.
Patent NO-312302-B1 (NO)
Title: Fremgangsmåte for katalytisk spaltning
Inventor: ELLINGSEN OLAV
IPC: C10G11/22
Filed: 1999-02-11
Abstract: Det er beskrevet en katalytisk spaltningsprosess hvori spaltningen finner sted i en reaktor under innvirkningen av en roterende fluidisert sjiktkatalysator og komprimerte gasser og/eller damp injiseres for å bevirke bevegelse av katalysatorsjiktet.
Patent NO-311060-B1 (NO)
Inventor: VILEID KARSTEN GROENENG
IPC: H04L12/803
Filed: 1999-07-14
Abstract: The present invention relates to a method for improving the traffic handling capacity of a packet switched mobile telephone communication system. In said system there is introduced a load sharing function between the Base Station System and the Serving GPRS Switching Node. The purpose of the load sharing function is to distribute the traffic load from the SGSN to a BSS among the available Network Service Virtual Channels.
Patent BG-60514-B1 (BG)
Title: Disposablesyringe
Inventor: RIGHI NARDINO
IPC: A61M5/32
Filed: 1992-01-14
Abstract: The syring has improved design which does not allow its secondary use the transmission of diseases and infections. The syringe includes a body (1) having an injection needle (4) mounted in its front end and a plunger (6) fitted axially in it and connected to the hand-operated stem (7) coming outside the rear end of the body (1). A protection cylinder (12) is mounted coaxially outside the body (1) enabling slide shifting from retracted position at rest where the injection needs 4) is freely open, to front safe position where the protection cylinder (12) is fitted around the injection needle (4) fully covering it. A locking device (23 & 25) is also provided for automatic retention of the protection cylinder (12) in its front safe position.
Patent BR-0012158-B1 (BR)
Inventor: RAMOND LOUIS
IPC: B29C45/20
Filed: 2000-07-05
Abstract: A device for injecting material in a plastic state into a moulding cavity is presented. The device includes a distributor of material in a plastic state including at least one outlet for material in a plastic state, placed along a preset axis. The device also includes an injection nozzle including at least one component which is connected to the distributor by a detachable connection and defines for the injection nozzle a front surface configured in such a way as to become integral with the moulding cavity. The injection nozzle includes at least one channel for material in a plastic state, placed along the axis, placed in a fluid relationship with the outlet, and emerging in the front surface. The device controls blanking of the channel.
Patent BR-0015474-B1 (BR)
Inventor: O'DWYER JAMES MICHAEL
IPC: F41H11/02
Filed: 2000-11-17
Abstract: A temporary airborne image is formed by the steps of arranging a plurality of projectiles in each of one or more barrel assemblies wherein the projectiles include image forming matter; firing a predetermined number of the plurality of projectiles from selected barrel assemblies; and deploying the image forming matter to form a temporary airborne image.
Patent BR-0017508-B1 (BR)
Inventor: ROOSE PETER
IPC: C23F11/14
Filed: 2000-06-20
Abstract: The use of a composition comprising a mixture of a C 1  - C 2  carboxylic acid salt and a C 3  - C 5  carboxylic acid salt as a coolant composition in automotive engines is described. The aqueous compositions may further comprise a hydrocarbyl triazole or a hydrocarbyl thiazole
Patent BR-0115399-B1 (BR)
Inventor: TULKKI OLAVI
IPC: F27D21/00
Filed: 2001-11-16
Abstract: The invention relates to a device for moving the belt of a belt conveyor used in continuously operated belt sintering between the drawing drum and the folding drum, and for aligning the belt sintering belt to be moved by the belt conveyor with respect to the sintering device. According to the invention, in order to rotate the drawing drum (2) of the belt conveyor used in belt sintering, in the immediate vicinity of the other end of the drawing drum, there is installed an actuator device (5, 6, 8) of the belt conveyor, where in at least one rotary element (5) that is installed co-centrically with the axis (15) of the drawing drum and cogged on the outer circumference, there is connected at least one actuator element (6) that is essentially smaller in diameter and cogged on the outer circumference, which actuator element (6) can be made to rotate by means of an actuating motor (8) belonging to the actuator device. Moreover, in order to align the belt (1) of the belt conveyor with respect to the sintering device (4), the actuator device of the belt conveyor is installed, with respect to the belt conveyor, so that the aligning of the belt (1) of the belt conveyor can, when necessary, be carried out essentially by moving the whole actuator device (5, 6, 8) of the belt conveyor.
Patent BR-0215665-B1 (BR)
Inventor: TULI RAKESH
IPC: A01N63/02
Filed: 2002-03-28
Abstract: A nucleic acid encoding a chimeric Cry1E delta endotoxin is taught, as are methods of using it to reduce insect infestation in plants.
Patent BR-9915472-B1 (BR)
Inventor: KIPPING CORNELIS MARIA
IPC: G05D7/01
Filed: 1999-11-12
Abstract: A device for controlling liquid flow in a conduit which is of a hat-like configuration defined by a cylindrical base part having a flange part at one end and a closure part at another end joined thereto by an integral spring which bends to permit through-flow of liquid through a peripheral gap between the body part and the closure part. The gap is of a stepwise progression including either an abrupt or curved step. The gap has a medial gap portion and opposite gap portion ends which are relatively sized to effect the stepwise progression.</PTEXT>
Patent CH-705431-B1 (CH)
Inventor: SORESINA CLAUDIO
IPC: A45D20/12
Filed: 2008-03-07
Abstract: Dispositivo (1) per il collegamento elettrico di elettrodomestici o di elettroutensili, comprendente un ricettacolo femmina (2) munito di due alloggiamenti (4a, 4b), un connettore maschio (3) inseribile in detto ricettacolo (2), dove detto connettore maschio (3) è munito di due mezzi di contatto elettrici (4a, 4b) tra loro concentrici, in modo tale da permettere la rotazione del connettore maschio (3) rispetto al ricettacolo femmina (2). L’invenzione concerne anche un asciugacapelli con un dispositivo come descritto sopra.
Patent CH-714886-B1 (CH)
Title: Kreuzstrahldüse und Lanzengerät zur Reinigung von Rohrbündeln.
Inventor: CHRISTOPH LENDI
IPC: B08B9/04
Filed: 2018-04-13
Abstract: Es soll erreicht werden, dass eine Kreuzstrahldüse (1), umfassend einen Rotorkörper (10), in welchen mehrere Kanäle von einer Düsenspitze (D) in Richtung eines Statorkörpers verlaufend ausgespart oder eingeformt sind, wobei mindestens zwei Frontstrahldüsen (103, 103') im Rotorkörper (10) durch mindestens zwei Frontstrahlkanäle (1030) derart platziert und orientiert ausgebildet sind, dass sich aus den Frontstrahlkanälen (1020) austretende Frontstrahlen eines Druckmediums ausserhalb des Rotorkörpers (10) kreuzen und der Rotorkörper (10) auf dem Statorkörper, der mit einem Hochdruckleitungsanschluss verbindbar ist, um seine gelagert Längsachse (L) rotierbar gelagert ist, gesichert parallel mittels einer Antriebseinheit eines Lanzengerätes in Rohre eingeführt wird, wobei Vorschubstörungen vermieden werden. Dies wird dadurch erreicht, dass die Düsenspitze (D) mit einer äusseren Oberfläche (O) derart versehen ist, dass die Oberfläche (O) konvex gewölbt kuppelförmig und kantenfrei ausgestaltet ist und die Düsenspitze (D) im Profil spiegelsymmetrisch zur Längsachse (L) geformt ist.
Patent CH-705087-B1 (CH)
Title: Pièce d'horlogerie.
Inventor: CHRISTOPHE LYNER
IPC: G04B35/00
Filed: 2012-06-06
Abstract: L’invention concerne une pièce d’horlogerie comprenant un mobile rotatif, notamment un balancier, muni d’un arbre de pivotement monté entre deux paliers solidaires respectivement d’une platine (1) et d’un pont, au moins une vis de fixation de ce pont sur la platine (1), au moins un organe de réglage de la distance entre le pont et la platine (1), muni d’une partie filetée vissée dans le pont. Cette pièce d’horlogerie a ceci de particulier que l’organe de réglage comprend une partie (9b) se présentant sous la forme d’une molette.
Patent CS-259925-B1 (CS)
Inventor: VANEK FRANTISEK
IPC: G01L1/22
Filed: 1986-12-28
Abstract: Řešení se týká zapojení zesilovače
a zdroje konstantního proudu pro tenzometrické
polomůstky a lze předpokládat,
že nalezne uplatnění ve- všech měřicích
a řídicích systémech, kde je zapotřebí
tenzometrických snímačů malých rozměrů
s velkou citlivostí. Zapojení řeší problém
dvojnásobného zvětšení výstupního
napětí tenzometrického snímače, tím
významné zlepšení poměru signál/šum a
dále zmenšení tenzometrických snímačů
s pouhými třemi vývody. Druhým nárokem
se řeší problém paralelního připojení
libovolného počtu tenzometrických snímačů
s jedním symetrickým napájecím zdrojem.
Podstata řešení spočívá v tom, že
k výstupním svorkám zdroje proudu je
připojena sériová kombinace dvou tenzometrů
a k ní paralelně sériová kombinace
dvou sčítacích odporů. Společný spoj dvou
tenzometrů je připojen přes druhý zpětnovazební
odpor k neinvertujícímu vstupu
operačního zesilovače a ke vstupu napěEového
sledovače. Společný spoj dvou sčítacich
odporů je připojen k invertujícímu
vstupu operačního zesilovače a jiřes první
zpětnovazební odpor k výstupu operačního
zesilovače, který je připojen k první výstupní
napěEové svorce. Výstup napěEového
sledovače je připojen k druhé výstupní
napěEové svorce.
Patent CS-253182-B1 (CS)
Inventor: BRAUN VLASTIMIL
IPC: B01D3/24
Filed: 1985-12-29
Abstract: Výplň je tvořena svisle vedle sebe
uspořádanými vodorovnými pásky, zvlněnými
šikmo ke svislici. Pásky jsou opatřeny
v řadách vedle sebe a střídavě pod sebou
přestupnými otvory, popřípadě i rýhami,
uspořádanými ve vodorovných řadách,
provedených střídavě po obou stranách
pásku. Pásek je v souhlase s předmětem
vynálezu opatřen nadto turbulizátory,
vylisovanými opět v řadách střídavě
z obou stran pásku. Turbulizátory mohou
mít tvar bradavek, vlnek či lístkových
žeber, souvislých či přerušovaných vodorovných
hřebenů, atp. Jsou rozmístěny
obvykle na ploše pásku mezi přestupnými
otvory, turbulizátory ve tvaru vlnek
či lístkových žeber anebo vodorovných
hřebenů mohou přecházet i přes přestupné
otvory
Patent CY-2378-B1 (CY)
Title: Rapamycin hydroxyesters, process for their preparation and pharmaceutical compositions containing them.
Inventor: SKOTNICKI JERAULD STANLEY
IPC: A61K31/00
Filed: 2003-09-12
Abstract: A compound of structure (I)   
wherein R 1  and R 2  are each, independently, hydrogen or - CO(CR 3 R 4 ) b (CR 5 R 6 ) d CR 7 R 8 R 9  ; 
R 3  and R 4  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, or -F; 
R 5  and R 6  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 , or R 5  and R 6  may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with - (CR 3 R 4 ) f OR 10 ; 
R 7  is hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 ; 
R 8  and R 9  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 , or R 8  and R 9  may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with -(CR 3 R 4 ) f OR 10 ; 
R 10  is hydrogen, alkyl, alkenyl, alkynyl, tri-(alkyl)silyl, tri-(alkyl)silylethyl, triphenylmethyl, benzyl, alkoxymethyl, tri-(alkyl)silylethoxymethyl, chloroethyl, or tetrahydropyranyl; 
R 11  is hydrogen, alkyl, alkenyl, alkynyl, or phenylalkyl; 
X is 5-(2,2-dialkyl)[1,3]dioxanyl, 5-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2-dialkyl)[1,3]-dioxanyl, 4-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2-dialkyl)[1,3]dioxalanyl, or 4-(2,2-dicycloalkyl)[1,3]dioxalanyl; 
b = 0-6; 
d = 0-6; and 
f = 0-6 
with the proviso that R 1  and R 2  are both not hydrogen and further provided that either R 1  or R 2  contains at least one -(CR 3 R 4 ) f OR 10 , X, or -(CR 3 R 4 ) f OR 10  substituted cycloalkyl group, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.