baber/WOPTO huggingface dataset:
Patent NZ-235884-A (NZ)
Title: 6-(2-imidazolin-2-ylamino)quinoxaline derivatives are used to prepare medicaments for reducing or maintaining intraocular pressure in a mammalian eye
Inventor: GLUCHOWSKI CHARLES
IPC: A61K31/498
Filed: 1990-10-30
Abstract: The invention provides the use of a compound of the formula (I) <CHEM> and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R1 is hydrogen, R2 is C1-4 alkyl or C1-4 alkoxy, the 2-imidazolin-2-ylamino group is in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R3, R4 and R5 are each located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and are independently selected from Cl, Br, hydrogen and C1-3 alkyl, for the manufacture of a medicament for reducing or maintaining intraocular pressure in a mammalian eye, for example an eye affected by glaucoma.  Also provided is the use of a compound of the formula (II) <CHEM> and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R1 and R2 are independently selected from hydrogen, C1-4 alkyl and C1-4 alkoxy; the 2-imidazolin-2-ylamino group is in any of the 6-, 7- or 8- positions of the quinoxaline nucleus, R3 is hydrogen or C1-3 alkyl, and R4 and R5 each are located in one of the remaining 6-, 7- or 8-positions of the quinoxaline nucleus and are selected from Cl, Br, H and C1-3 alkyl radicals, for the manufacture of a medicament for reducing or maintaining the intraocular pressure in a mammalian eye, for example an eye affected by glaucoma. The invention also provides topical ophthalmic compositions comprising a compound of the formula (I) or (II) and an ophthalmically acceptable carrier.
Patent NZ-238216-A (NZ)
Title: Dispensing bottle with side gripping portions
Inventor: ZOGG JON
IPC: B65D1/00
Filed: 1991-05-21
Abstract: for gripping and manipulating the bottle. The indentation are designed to provide for the same gripping feel whether gripped front or the back. The indentations are also designed to accept a thumb and one to four fingers. The positive gripping with the same grip feel allows the bottle to be used in either hand. This decreases the number of times that a bottle must be handled during use. It also decreases the likelihood that the bottle will be dropped while being handled. <IMAGE>
Patent NZ-243357-A (NZ)
Title: Non invasive ultrasonic leanness grading of meat
Inventor: MICHEL THOMAS EDWARD
IPC: G01N29/00
Filed: 1992-06-29
Abstract: A non-invasive apparatus and method for measuring fat thickness or content and muscle depth or area parameters grading meat and animals are disclosed. The device includes an ultrasonic transducer and analyzer device which provides A scan information in digitized form. A separate controller moves the ultrasonic transducer along a predetermined path adjacent an animal or carcass while A scans are obtained at predetermined locations along the path. The A scans are digitized and analyzed to determine the tissue interface boundaries. Equations are implemented to determined the area of the longissimus muscle and fat tissue thicknesses and a lean content rating for the animal may be determined therefrom. Modeling techniques are also used to estimate certain portions of the area of the longissimus muscle of the animal or carcass based upon data gathered during the ultrasound scanning of the carcass. <IMAGE>
Patent NZ-250490-A (NZ)
Title: Hiv protease inhibitors and medicaments
Inventor: HUI KWAN YUK
IPC: A61K31/4418
Filed: 1993-12-17
Abstract: The present invention provides novel HIV protease inhibitors, of formula I <CHEM>  wherein:   Z   is hydrogen, formyl, carbamoyl, C2-C6 alkanoyl, C1-C4 alkoxycarbonyl, -C(O)CF3 or -S(O)2-R, where R   is C1-C6 alkyl, amino, trifluoromethyl, C1-C4 alkylamino, di(C1-C4)alkylamino, aryl, aryl(C1-C4)alkyl, heterocycle, unsaturated heterocycle or C5-C7 cycloalkyl; R<1>   is aryl, C5-C7 cycloalkyl or -S-R<1x>, where R<1x> is aryl or C5-C7 cycloalkyl; R<2>   is an amino acid side chain, -(CH2)y-X-R<2a>, cyano(C1-C4)alkyl or -(CH2)y-S(O)w-[1-N(R<2c>)-tetrazol-5-yl], where        y is 0, 1, 2 or 3; X is a bond, divalent(C2-C4)alkenyl, divalent(C2-C4)alkynyl, -C(O)-O-, -O-C(O)-, -C(O)-NR<2b>-, -NR<2b>-C(O)-, -NR<2b>-, -C(O)-, -O-, -S(O)w-;        w is 0, 1 or 2; R<2a> is C1-C6 alkyl, aryl, unsaturated heterocycle, heterocycle, aryl(C1-C4)alkyl, unsaturated heterocycle(C1-C4)alkyl or heterocycle(C1-C4)alkyl;        R<2b> is hydrogen or C1-C4 alkyl; R<2c> is hydrogen, C1-C6 alkyl, aryl, unsaturated heterocycle, aryl(C1-C4)alkyl or unsaturated heterocycle(C1-C4)alkyl; Y   is aryl or unsaturated heterocycle; R<3>   is a group having the structure: <CHEM>   <CHEM>   <CHEM>   <CHEM>   <CHEM>   <CHEM>  where:        p is 4 or 5;        l is 3, 4 or 5; R<4> at each occurrence is independently hydrogen, C1-C6 alkyl or hydroxy(C1-C4)alkyl; R<5> and R<6> are independently selected from hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, amino, C1-C4 alkylamino, hydroxy(C1-C4)alkyl, carboxy, C1-C4 alkoxycarbonyl, carbamoyl, N-(C1-C4)alkylcarbamoyl, aryl, heterocycle or unsaturated heterocycle; o
Patent NZ-262676-A (NZ)
Title: Method of inhibiting angiogenesis in a non-human animal using thalidomide and analogues thereof
Inventor: D AMATO ROBERT
IPC: A61K31/404
Filed: 1994-02-24
Abstract: Thalidomide for treating solid and blood-borne tumours, wherein said tumour is a breast cancer, leukaemia, neoplastic disease of the bone marrow, Kaposi's sarcoma, hemangioma, rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, osteosarcoma, acoustic neuroma, neurofibroma, trachoma, or pyogenic granuloma;and for treating ocular neovascular disease, macular degeneration, proliferative vitreoretinopathy, retrolental fibroplasia, psoriasis, Crohn's disease, diabetic retinopathy, Osler-Weber-Rendu disease, hereditary hemorrhagic telangienctasia or osteoarthritis.
Patent NZ-270764-A (NZ)
Title: Liquid dispenser for pot plant watering or room odorising with container, flow regulator and intermittent dispenser
Inventor: CAMPAU DANIEL N
IPC: A01G27/00
Filed: 1995-03-21
Abstract: An automatic liquid dispensing apparatus including a container (20) for holding a dispensable liquid (15), a flow regulator (30) which permits liquid to flow out of the container at a controlled rate which is independent of the quantity of liquid within the container, and a timing and dispensing assembly (53). The timing and dispensing assembly accumulates a quantity of the liquid from the flow regulator (30), and periodically dispenses a constant volume of the liquid. <IMAGE>
Patent NZ-270810-A (NZ)
Title: Self-adhesive transdermal matrix system comprising 40-60 parts ethylene/vinyl acetate copolymer and a hormone
Inventor: TEILLAUD ERIC
IPC: A61K47/16
Filed: 1995-03-27
Abstract: Self-adhesive transdermal matrix material for percutaneous admin. of a hormone comprises (1) a support and (2) a self-adhesive matrix consisting of (by wt.); (a) 40 - 60 pts. ethylene-vinyl acetate copolymer (EVA); (b) 5 - 20 pts. cellulose deriv. (I); (c) 35 - 55 pts. at least one of crotamiton (II); N-substd. 2-pyrrolidones of formula (III) or 12-20C aliphatic alcohol (IV) and (d) 0.01-7 pts. oestrogenic and/or progestational hormone. R = 1-15C alkyl, cyclohexyl or 2-hydroxyethyl.
Patent NZ-270866-A (NZ)
Title: Bicyclic (hetero)aryl(-oxy,-thio and -amino) benzoic acid derivatives
Inventor: BERNARDON JEAN-MICHEL
IPC: A61K8/00
Filed: 1995-04-04
Abstract: Bicyclic aromatic cpds. of formula (I), their salts and chiral analogues, are new. R1 = H, -CH3, -CH2-O-R3, -CH2-O-CO-R4, -O-R5, -O-(CH2)m-(CO)n-R6, -CO-R7, -CO-O-R8 or -S(O)p-R9, R2 = H, halo, lower alkyl, -NO2, -O-COR4, -OR9 or -N(R9)R10, Ar = a gp. of formula (a)-(e), X = -O-, -S(O)t or -NR9-, Y, Z = -O-, -S(O)t or -CR11R12, but are not both -O- or -S(O)t, m = 1-3, n = 0 or 1, p = 0, 1-3, t = 0, 1 or 2; R3, R5, R9, R10, R11, R12 = H or lower alkyl, R4 = lower alkyl, R5 = lower alkyl or heterocyclic radical, R7 = H, lower alkyl or -N(R')R", R', R" = H, lower alkyl, mono- or poly-hydroxyalkyl, aryl (opt. substd.) or an aminoacid, sugar or peptide residue, or R'+R" = heterocyclic gp., R8 = H, 1-20C alkyl, alkenyl, mono- or poly-hydroxyalkyl, aryl or aralkyl (opt. substd.) or an aminoacid, sugar or peptide residue.
Patent NZ-274346-A (NZ)
Title: Use of various thiazolidine-2,4-dione and oxazolidine-2,4-dione derivatives to prevent or delay onset of non-insulin dependent diabetes mellitus
Inventor: OLEFSKY JERROLD
IPC: A61P5/50
Filed: 1994-09-14
Abstract: A novel method of using thiazolidinedione derivatives and related antihyperglycemic agents to treat populations experiencing impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom is disclosed.
Patent NZ-276137-A (NZ)
Title: Targeting molecule/enzyme conjugates, their use and intermediate compounds
Inventor: SMITH GARY KEITH
IPC: A61K47/48
Filed: 1994-11-11
Abstract: The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.
Patent NZ-335338-A (NZ)
Title: A transportable structure kit
Inventor: VON HOFF CHRISTIANE
IPC: E04B1/344
Filed: 1997-03-17
Abstract: A transportable structure kit (10) is readily transportable within a container (50).  The container (50) has exterior container panel sections (11'1-11'6) adapted to attach together to form a completely enclosed transportable container (50).  Exterior container panel wall sections (11'1-11'6) comprise a planar floor section, planar side walls, planar end walls and a planar ceiling section.  A number of interior panel sections (15) are placed within the enclosed transportable container (50).  The exterior container panel sections (11) are detachably attached together to form enclosed transportable container (50) in a transportation mode.  The planar floor section and at least the two planar side walls are adapted to be attached together to form a floor of the housing structure.  The exterior container panel wall sections (11) in the transportation mode attach to one another with a plurality of bolts to enable prior assembly of the housing structure.  The bolts are adapted to be removed so that the planar side walls may be removed from the transportable structure kit (10) and placed on respective opposite sides of the planar floor section to form at least a portion of the floor in the housing structure.   Means (51) on the corners of the enclosed transportable container are adapted to allow transportable container (50) to be hoisted and moved.
Patent NZ-336790-A (NZ)
Title: 16,17-dihydroxy-11-(substituted phenyl)-17-(1-propynyl)-estra-4,9-diene derivatives
Inventor: GROEN MARINUS BERNARD
IPC: C07J51/00
Filed: 1998-01-13
Abstract: The 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives have the formula I wherein: R1 is alkyl, cycloalkyl, alkoxy, triflate, pyridyl or optionally substituted phenyl; R2 is hydrogen, alkyl, 1-oxo-alkyl or carboxy-1-oxo-alkyl; R3 is hydrogen, halogen or optionally substituted alkyl; R4 is hydrogen, alkyl, 1-oxo-alkyl or carboxy-1-oxo-alkyl and X is (H, OH), O or NOH or a pharmaceutically acceptable salt or solvate thereof. A pharmaceutical formulation thereof is useful in the treatment or prophylaxis of glucocorticoid dependent diseases or symptoms.
Patent NZ-500206-A (NZ)
Title: MPEG receiver decoder with computer function incorporating virtual machine
Inventor: SARFATI JEAN-CLAUDE
IPC: H04N5/00
Filed: 1997-04-25
Abstract: A receiver/decoder for a broadcast digital television system in which received signals are passed through a receiver to the receiver/decoder and then to a television set. The receiver/decoder decodes a compressed MPEG-type signal, and is controlled by a remote controller handset, through an interface in the receiver/decoder. The operation of the receiver/decoder is controlled by a virtual machine (VM) which includes a run time engine (RTE). The receiver/decoder includes a plurality of interfaces to external units, and logical driver devices for the interfaces. Applications control the external units by the RTE, which receives events from the interfaces via a set of queues. The RTE comprises a plurality of process sequencer units associated with the device means, and means for extracting events from the queue means and actuating the associated process sequencer units accordingly.
Patent NZ-500885-A (NZ)
Title: Cytokine-like factor 7 (zcyto7) expressed in spinal cord reveals that zcyto7 plays a role in the maintenance of spinal cord involving either glial cells or neurons
Inventor: GILBERT TERESA
IPC: C07K19/00
Filed: 1998-04-23
Abstract: Isolated peptides, monoclonals, polyclonals and expression system thereof for a mammalian cytokine-like factor 7 (Zcyto7) specifically expressed in the spinal cord. Zcyto7 can be used to treat a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), or de-myelinating diseases including multiple sclerosis. Zcyto7 may also be used to treat sensory neuropathis.
Patent NZ-501887-A (NZ)
Title: Encrypting smart card transaction PIN by cryptogram derived from encrypted transaction data
Inventor: VINER JOHN CHARLES
IPC: G06Q20/34
Filed: 1998-06-26
Abstract: In a payment process using a smart card, security of the communication with the financial institution is very important. The card is read in a terminal that is in two-way communication with the financial institution. As part of the payment process, a cryptogram of the transaction data is made by the smart card, using a cryptographic key known to or derivable by the financial institution, and used in the terminal as a key to encrypt the PIN, entered by the cardholder, for transmission to the financial institution. The financial institution also creates a cryptogram, using the transaction data sent to it by the terminal, and uses this cryptogram (which should be the same as that created by the smart card) to decrypt the encrypted PIN. In this way, the use of an expensive tamper-resistant encrypting PIN pad at the terminal is avoided, whilst maintaining security.
Patent NZ-502379-A (NZ)
Title: Substituted alkanohydroxamic acids and use in pharmaceuticals for reducing TNF-alpha levels
Inventor: MULLER GEORGE W
IPC: C07D413/04
Filed: 1998-07-30
Abstract: Described are hydroxamic acid derivatives of formula (I), wherein R1 and R2, independently of each other is hydrogen, lower alkyl, or R1 and R2 when taken together is o-phenylene, o-naphthylene, or cyclohexene-1,2-diyl, optionally substituted with 1 to 4 substituents selected from nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkylamino, dialkylamino, acylamino, C1-10-alkyl, C1-10-alkoxy, C3-6-cycloalkoxy,                                        C4-6-- cycloalkylidenemethyl, C3-10-alkylidenemethyl, indanyloxy, and halo, and R3 is phenyl substituted with from one to four substituents selected from nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, C1-10-alkyl, C1-10-alkoxy, C3-6-cycloalkoxy, and halo, or R3 is         C4-6 cycloalkylidenemethyl, C3-10-alkylidenemethyl or indanyloxy, and R4 is hydrogen, C1-10-alkyl, phenyl, or benzyl, and R4' is hydrogen or C1-6-alkyl, and R5 is -CH2-, -CH2-CO-, -CO-, -SO2-, -S-, or -NHCO-, and n has a value of 0, 1, or 2. The compounds have uses in reducing tumor necrosis factor á (TNFá) in mammals.
Patent NZ-503440-A (NZ)
Title: Electric water heater with simplified phase conversion apparatus
Inventor: HENDERSON DAVID L
IPC: F24H9/18
Filed: 2000-03-16
Abstract: Provided is an electric water heater (10) with a simplified phase electrical conversion apparatus (18) including a terminal structure (34) having replaceable line lug portions (52) which are wired to a single phase row of multi-pin connector sockets by single phase routing circuitry (42), and to a three phase row of multi-pin connector sockets by three phase routing circuitry (42).  Electrical supply wires (22, 24) from set of fuse holders (20) connect to multiple thermostat/heating element sets (13, 16) are grouped and connected to associated multi-pin connector plugs (50).  To ready the water heater for single phase operation, the plugs (50) are connected to the single phase row of sockets, and to convert the water heater to three phase operation the plugs (50) are disconnected from the single phase sockets and connected to the three phase sockets.
Patent NZ-509105-A (NZ)
Title: Cyclic 24-membered depsipeptides for controlling ectoparasites
Inventor: JESCHKE PETER
IPC: A01N43/84
Filed: 1999-06-11
Abstract: Described is the use of cyclooctadepsipeptide derivatives of formula (I) for the prevention and treatment of ectoparasitic infection in humans and animals. R1 and R2 independently represent H, C1-4 alkyl, OH, halo, C1-4 alkoxy, (C1-4 alkoxy)-(C1-4 alkyl), heterocyclyl, heteroarylethoxy, heteroarylmethoxy, NO2, NH2, di-(C1-4 alkyl)amino, N-morpholino, N-pyrrolidino or N-piperidino;  X1-X4 are independently O or S, provided that when R1 and R2 are both H, then at least one of X1-X4 is S.
Patent NZ-511845-A (NZ)
Title: Spraying system, typically for beehive, with spraying of combined entrance and exit passage
Inventor: WILLACY GEOFFREY VALENTINE
IPC: A01G7/00
Filed: 2001-05-22
Abstract: A treatment delivery system 1 is connected to a combined entrance/exit 2 of a beehive 3. Nozzle 7 sprays treatment agents onto the surfaces f ramp 4 which bees must pass over.
Patent NZ-512510-A (NZ)
Title: A latch device
Inventor: FOUNTAINE HOWARD JOHN
IPC: E05C3/10
Filed: 2001-06-20
Abstract: A lock device for sliding and hung window systems, the latch device including a mounting base (10), a pair of counter-rotatable cam elements (11) coupled to the base (10), a lever cover (12) slidingly engaged with the mounting base (10) and a coupling mechanism which couples the lever cover (12) to the cam elements (11) whereupon in use a sliding movement of the lever cover (12) is translated into pivotal movement of the cam elements (11).
Patent NZ-513469-A (NZ)
Title: Device for treating fractured or diseased bone using expandable bodies deployed asymetrically from a catheter
Inventor: SCHOLTEN ARIE
IPC: A61B19/00
Filed: 1998-06-01
Abstract: A device for compacting cancellous bone comprising a catheter tube having a distal end that extends along a first essentially linear axis, and a structure mounted about the distal end and comprising a body adapted to assume a collapsed geometry for deployment into bone and an geometry for compacting cancellous bone to form a cavity, the expanded geometry being oriented about a second essentially linear axis not aligned with the first essentially linear axis.
Patent NZ-514756-A (NZ)
Title: Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
Inventor: HOGENKAMP DERK J
IPC: C07D277/32
Filed: 2000-03-24
Abstract: This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Patent NZ-519219-A (NZ)
Title: Novel bisamidate phosphonate prodrugs
Inventor: JAING TAO
IPC: C07F9/6512
Filed: 2000-12-22
Abstract: Novel bisamidate phosphonate prodrugs of FBPase inhibitors of the Formula (IA) and their use in the treatment of diabetes and other conditions associated with elevated blood glucose.
Patent NZ-522596-A (NZ)
Title: Apparatus for producing a yarn
Inventor: LEE DAVID ARTHUR
IPC: C03B37/03
Filed: 2002-11-14
Abstract: Apparatus for producing a yarn including a reciprocating twisting stage adapted to simultaneously twist one or more slivers to produce one or more twisted strands including one or more rollers arranged to move reciprocally along the axis of rotation of the roller(s) to impart twist to the sliver(s), and a control system which enables controlled variation of the rotational speed of the one or more rollers during operation of the apparatus, to impart a varying degree of twist to the sliver(s) or strand(s) along the length thereof as the sliver(s) or stand(s) pass through the apparatus.
Patent NZ-524181-A (NZ)
Title: Use of toremifene in women during or after the menopause for treating vaginal dryness or sexual dysfunction
Inventor: HALONEN KAIJA
IPC: A61P15/12
Filed: 2001-05-02
Abstract: (Deaminohydroxy) toremifene can be used in the manufacture of a pharmaceutical condition for the treatment of vaginal dryness or sexual dysfunction in women during or after menopause. Preferably the composition is formulated to be administrated orally or transdermally.
Patent NZ-530012-A (NZ)
Title: Anti-bacterial vaccine compositions
Inventor: LOWERY DAVID E
IPC: A61K39/00
Filed: 2000-04-06
Abstract: An attenuated Pasteurellaceae bacteria comprising a mutation in a gene having a nucleotide sequence set forth in SEQ ID NO:76 is described. The mutation results in decreased yiaO biological activity of a gene product encoded by the mutated gene, wherein the decreased yiaO biological activity attenuates the bacteria. Also described are vaccine compositions comprising the bacteria, isolated polynucleotides and polypeptides, vectors, non-human host cells, antibodies and methods for producing a gram-negative mutant. A method of identifying an anti-bacterial agent comprises the steps of assaying potential agents for the ability to interfere with expression or activity of a yiaO gene product, represented by the amino acid sequence set forth in SEQ ID NO: 77, and identifying an agent that interferes with yiaO gene expression or biological activity of the gene product. (62) Divided out of 514883
Patent NZ-535274-A (NZ)
Title: Method for selecting a cementing composition for cementing wells
Inventor: RAVI KRISHNA M
IPC: E21B33/14
Filed: 2003-02-21
Abstract: A method is provided for selecting a cementing composition for sealing a subterranean zone penetrated by a well bore. The method involves comprising determining a group of effective cementing compositions from a group of cementing compositions given estimated conditions experienced during the life of the well, and estimating the risk parameters for each of the group of effective cementing compositions.
Patent NZ-535311-A (NZ)
Title: Nucleotide sequence coding for a tolc and a defined amino acid sequence
Inventor: GOEBEL WERNER
IPC: A61P31/04
Filed: 2003-02-13
Abstract: Disclosed is a nucleotide sequence coding for a TolC and a defined amino acid sequence, said defined amino acid sequence being inserted in the permissive, membrane-external area of the TolC, and several uses thereof, particularly bacteria containing such a nucleotide sequence. The TolC is a TolC protein according to Accession X54049.
Patent NZ-536174-A (NZ)
Title: Process for preparing acid salts of gemifloxacin
Inventor: CHOI HOON
IPC: C07D471/04
Filed: 2003-04-04
Abstract: A process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process, improvement of productivity and improvement of yield, and the like by reducing conventional three-step process to two-step process.