baber/WOPTO huggingface dataset:
Patent CA-2548808-A1 (CA)
Title: Monoclonal antibodies that bind or neutralize dengue virus
Inventor: LAI CHING-JUH
IPC: C12N15/68
Filed: 2004-12-03
Abstract: The present invention relates to monoclonal antibodies that bind or neutralize dengue type 1, 2, 3, and/or 4 virus. The invention provides such antibodies, fragments of such antibodies retaining dengue virus-binding ability, fully human or humanized antibodies retaining dengue virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
Patent CA-2548815-A1 (CA)
Inventor: KOJIMA MASAKIYO
IPC: B60K6/20
Filed: 2002-10-08
Abstract: A hybrid-vehicle drive method and system includes an internal combustion engine that includes an output shaft, a first electric motor/generator connected to the output shaft of the internal combustion engine via a power distribution mechanism, a wheel drive shaft connected to the output shaft of the internal combustion engine via the power distribution mechanism, a second electric motor/generator connected to the wheel drive shaft, and a transmission located on at least one of the wheel drive shaft and a connecting portion of the second electric motor/generator with the wheel drive shaft.
Patent CA-2549954-A1 (CA)
Title: Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide, preparation method thereof and use of same in therapeutics
Inventor: LECLERC ODILE
IPC: C07D487/08
Filed: 2005-01-07
Abstract: 4-heterocyclylcarbonyl-1,4-diazacyclo-octane derivatives (I), as individual or mixed enantiomers, bases, solvates and acid addition salts are new. 4-heterocyclylcarbonyl-1,4-diazacyclo-octane derivatives of formula (I), as individual or mixed enantiomers, bases, solvates and acid addition salts are new. X : N or CR 2; P, Q, R and W : N or CR 3; R 1 and R 21-6C alkyl; R 3hydrogen, halo, 1-6C alkyl or alkoxy, nitro, amino, trifluoromethyl, cyano, NR 4R 5, NR 4COR 5, NR 4CONR 5R 6, NR 4COOR 5, NR 4SO 2NR 5R 6, OR 5, OCOR 5, OCOOR 5, OCO-ONR 4R 5. OCOSR 5, COOR 5, COR 5, CONR 4R 5, SR 5, SOR 5, SO 2R 5, SO 2NR 4R 6, or phenyl (optionally substituted by any of the groups indicated for R 3), or R 3 is any of a wide range of heterocyclic groups (het1); R 4, R 5 and R 6halo, 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-8C cycloalkyl, 3-8C cycloalkyl(1-3C)alkyl, 4-8C cycloalkenyl or phenyl, and RNR 4R 5 or NR 5R 6 may complete a heterocycle (het2). The full definitions are given in the DEFINITIONS (Full Definitions) Field. [Image] ACTIVITY : Nootropic; Neuroprotective; Neuroleptic; Antiparkinsonian; Anticonvulsant; Tranquilizer; Antidepressant; Cardiant; Antiulcer; Antismoking. MECHANISM OF ACTION : (I) are ligands for nicotinic receptors, with high selectivity for receptors that include the alpha 7 subunit. The compound 3-(1,4-diazabicyclo[3,2,1]oct-4-yl-carbonyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine hydrobromide had IC 50 for inhibition of binding of tritium-labeled alpha -bungarotoxin to nicotinic receptors that contained the alpha 7 subunit of 0.056 mu M.
Patent CA-2549981-A1 (CA)
Inventor: ANTON BRYCE
IPC: B44C1/00
Filed: 2006-06-13
Abstract: An article having a decorative, visibly-patterned, multi-colored surface appearance includes a substrate and a first coating provided by vapor deposition above at least a portion of the substrate, the coating comprising a first material having a first color. The coating comprises a random arrangement of penetrations through which a portion of an underlying surface is visible, the underlying surface comprising a second material having a second color that differs from the first color. The penetrations form a decorative pattern comprising features distinguishable to an unaided human eye.
Patent CA-2552090-A1 (CA)
Title: Disubstituted chalcone oximes as selective agonists of rar.gamma. retinoid receptors
Inventor: TSANG KWOK YIN
IPC: A61K31/4706
Filed: 2004-12-21
Abstract: Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RAR.gamma. agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.
Patent CA-2553345-A1 (CA)
Title: Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
Inventor: LYNCH JOSEPH E
IPC: C07D249/08
Filed: 2005-01-21
Abstract: Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11.beta.-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment.  The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
Patent CA-2555826-A1 (CA)
Inventor: MACEVILLY CONOR J
IPC: A61K9/00
Filed: 2005-02-17
Abstract: Pharmaceutical compositions and methods are described comprising at lease one Y2 receptor-binding peptide, such as peptide YY (PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
Patent CA-2558435-A1 (CA)
Title: Methods for inducing autolysis in infectious bacteria
Inventor: PORTER ANDREW JUSTIN RADCLIFFE
IPC: C07K16/44
Filed: 2005-03-24
Abstract: The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.
Patent CA-2559109-A1 (CA)
Inventor: COULTON MICHAEL S
IPC: E04D13/17
Filed: 2006-09-06
Abstract: A roof ridge vent has a pair of opposed, spaced-apart, elongate strips of ventilation material providing ventilation passageways transversely therethrough and forms opposed longitudinally-extending sides of the vent. The elongate ventilation strips are interconnected by a plurality of supports extending transverse relative to the elongate ventilation strips. Each adjacent pair of supports define an opening therebetween such that an underlying roof surface is visible to an installer through the openings. A vent assembly and method of installation are provided.
Patent CA-2559861-A1 (CA)
Title: Fully inhibited dual chamber pacing mode
Inventor: STROEBEL JOHN C
IPC: A61N1/368
Filed: 2005-03-23
Abstract: A pacing mode is provided, in one embodiment, that permits missed or skipped ventricular beats. The mode monitors a full cardiac cycle (A-A interval) for the presence of intrinsic ventricular activity. If ventricular activity is present, a flag is set that is valid for the next cardiac cycle. At the beginning of the next cardiac cycle, the device determines if the flag is present. So long as the flag is present, the device will not deliver a ventricular pacing pulse in that cycle, even if there is no intrinsic ventricular activity. If there is no flag present at the start of a given cardiac cycle, a ventricular pacing pulse is delivered and this ventricular activity sets a flag for the subsequent cardiac cycle.
Patent CA-2559945-A1 (CA)
Title: Pyrazole compounds and uses related thereto
Inventor: TU HUA
IPC: C07D403/10
Filed: 2005-03-21
Abstract: Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
Patent CA-2561514-A1 (CA)
Inventor: RIES RANDALL R
IPC: F25B41/04
Filed: 2006-09-28
Abstract: A refrigeration system for freezing fluid in a tray during a first operating mode and defrosting the ice during a second operating mode to facilitate the removal of the ice from the tray. In the first operating mode, refrigerant circulates through a circuit in a first direction and, in the second mode, the flow of refrigerant is reversed in a portion of the circuit. In the first operating mode, cool refrigerant exits an expansion device in the circuit and enters into the evaporator to freeze a fluid in the tray. In the second operating mode, a valve is operated to permit warm refrigerant exiting the compressor to enter into the evaporator to melt a portion of the ice reversing the flow of refrigerant therein. A second valve permits the reverse flow of refrigerant through the evaporator to return to the compressor inlet instead of passing through the expansion device and condenser.
Patent CA-2562595-A1 (CA)
Title: Train handling techniques and analysis
Inventor: ONODIPE BOLANLE
IPC: G07C5/08
Filed: 2000-09-16
Abstract: This is a method of analyzing train handling by setting a standard for the run, collecting train operating or handling data from the run and determining operating constraints during the run which are not included in the standard run. The determination of operating constraints during a run also includes determining differences between the operating constraints during the run of those included in the standard. The train handling data is compared to the standard and the comparison is adjusted for the operating constraints. The adjustment of the comparison includes nullifying any deviation of the handling data from the standard resulting from the operating constraints. A report is created from the standard and the handling data correlating the energy usage for specific categories. These categories include one or more of pneumatic braking, dynamic braking and track topology. The report further includes energy adjustments for the operating constraints determined during the run.
Patent CA-2565175-A1 (CA)
Title: Cancer diagnosis and treatment using anti-robo1 antibody
Inventor: ITO HIROTAKA
IPC: C12N15/09
Filed: 2005-03-31
Abstract: A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
Patent CA-2566381-A1 (CA)
Inventor: BOOSY MOSHE
IPC: E04F15/08
Filed: 2005-03-30
Abstract: The present invention relates to sheets of mosaic tile, and an apparatus and method of using that apparatus, for their production. In particular, the present invention provides mosaic tile sheets in which the individual mosaic tile subunits are attached to a rigid support (21) such that the finished faces of the mosaic tile subunits are aligned in the same plane (or in the same curved surface).
Patent CA-2566705-A1 (CA)
Inventor: NOTT PETER THOMAS MENCE
IPC: A62B1/10
Filed: 2005-05-13
Abstract: There is provided height rescue apparatus comprising a casing (9) which incorporates a bracket for attachment to a harness (2). The bracket can be releasably attached to a load element (11) which is attached to a safety line (10) which in turn can be attached to a secure anchorage. There is also a release means in the form of a pull cord (38) for releasing the load element (11) from the bracket (4) after a fall and speed control means for controlling the rate of deployment of an elongate element stored within the casing (9) and thus controlling the descent of a user (1).
Patent CA-2567731-A1 (CA)
Inventor: ZHU LIZHI
IPC: H02M3/335
Filed: 2005-05-27
Abstract: A power converter architecture interleaves full bridge converters to alleviate thermal management problems in high current applications, and may, for example, double the output power capability while reducing parts count and costs. For example, one phase of a three phase inverter is shared between two transformers, which provide power to a rectifier such as a current doubler rectifier to provide two full bridge DC/DC converters with three rather than four high voltage inverter legs.
Patent CA-2568770-A1 (CA)
Inventor: GALLOPS HENRY M JR
IPC: F41B5/14
Filed: 2006-11-23
Abstract: A preferred embodiment of the present invention includes a compression mold for forming an archery bow limb. The compression mold comprises a mold assembly defining a mold cavity for receiving a resin and fiber slug. The mold cavity defines a limb tip area with outer limb tip portions. The mold assembly defines the mold cavity in the shape of an archery bow limb. The mold assembly further comprises a protrusion formed in the mold cavity. The protrusion includes a crown configured to urge glass fibers in the slug into the outer limb tip portions.  The protrusion forms a depression to be ground to form a limb tip slot in the archery bow limb. In preferred embodiments, the protrusion includes a middle tapered area having a summit. In preferred embodiments, the outer limb tip portions have a higher glass fiber density than a remainder of the archery bow limb.
Patent CA-2573258-A1 (CA)
Inventor: ANDERSON BENJAMIN T
IPC: A43B9/00
Filed: 2007-01-08
Abstract: A shoe for use by a person having paralysis or other restriction of mobility of one foot allows the foot to roll during physiotherapeutic training to gain walking ability. The upper body is used to at least partially support the person on an appropriate aid device during a step taken by the other foot having retained mobility.  The shoe worn on the foot of restricted mobility has at least one omnidirectional roller member at the bottom thereof to allow the foot to roll forward to a position where a subsequent step can be taken. The relatively low level of friction involved in initializing the rolling motion of the foot reduces or eliminates reliance on another person to help move the foot forward during physical therapy.
Patent CA-2573349-A1 (CA)
Inventor: STELLNERT MATS
IPC: F04B49/00
Filed: 2005-06-20
Abstract: Une source de vide permettant de produire un vide dans au moins un premier système de purge à travers des conduits, comprend au moins une première et une seconde pompe à vide. La source de vide comprend un système qui est adapté pour détecter l'écoulement d'air consommé, et pour régler chacune des première et seconde pompe à vide sur la base de l'écoulement d'air détecté.
Patent CA-2574040-A1 (CA)
Title: Composes de liaison aux proteines iap
Inventor: DENG YIJUN
IPC: A61K31/40
Filed: 2005-07-15
Abstract: L'invention concerne des molécules de liaison aux protéines IAP et des compositions comprenant lesdites molécules. Ces molécules de liaison aux protéines IAP interagissent avec lesdites protéines IAP (protéines inhibitrices de l'apoptose) dans des cellules et peuvent être utilisées pour modifier l'apoptose dans les cellules traitées par lesdites molécules. Dans certains modes de réalisation, les composés de l'invention présentent une constante Kd inférieure à 0,1 micromole. L'invention concerne également des procédés d'utilisation desdites molécules de liaison aux protéines IAP à des fins thérapeutiques, diagnostiques, et d'analyse.
Patent CA-2575853-A1 (CA)
Inventor: UKKIRAMAPANDIAN RADHAKRISHNAN
IPC: C07D409/12
Filed: 2005-08-12
Abstract: The present invention is directed to compounds of formula (I), wherein R1 is a ring and n is a number from 1 to 8. The invention also relates to use of the compounds in therapy as metabotropic glutamate receptor modulators, particularly in neurological and psychiatric disorders.
Patent CA-2576075-A1 (CA)
Title: Surfactants not toxic to bacteria
Inventor: CHEN YIYAN
IPC: E21B43/26
Filed: 2007-01-29
Abstract: An oilfield treatment method is given that uses fluids that contain surfactants used as foamers and/or viscosifiers such that the fluids pass the Alberta Energy and Utilities Board Directive 27 requirements for low toxicity to certain bioluminescent bacteria.  Such fluids may be used in oilfield treatments, for example drilling and stimulation, near fresh water aquifers. The surfactants are certain non-ionic surfactants that are not aromatic, or certain amphoteric surfactants (that can be neutral), or certain zwitterionic surfactants, (in which both positive and negative charges are present in a single molecule so that the whole molecule is neutral).
Patent CA-2578381-A1 (CA)
Inventor: MUEHLBERGER PETER
IPC: A63B57/00
Filed: 2005-08-30
Abstract: The invention relates to a holding element (600, 700, 800) for tees, which is usable on golf-knocking carpets. The inventive holding element comprises several holders (610, 710, 810) combined into a bundle or a tuft, wherein said bundle or tuft is expandable oppositely to a tensile force substantially acting in a plane.
Patent CA-2580464-A1 (CA)
Inventor: ARBO BENTE E
IPC: A61K51/08
Filed: 2005-09-28
Abstract: The invention relates to contrast agents for detection of the Urokinase Plasminogen Activator Receptor (uPAR). More specifically the invention relates to contrast agents comprising a peptidic vector binding to the uPAR, labelled with an imageable moiety.
Patent CA-2580711-A1 (CA)
Title: Automatic user availability status determination for a handheld communication device
Inventor: WISEBOURT SHAUL S
IPC: H04M1/72451
Filed: 2005-02-03
Abstract: To automatically determine the availability status of the user of a handheld communication device, various selected conditions of the device may be checked, which imply whether or not the user is likely Available, or Unavailable or the equivalent. Normally, the selected conditions are checked only if the user has not explicitly or semi-explicitly set his or her status to Unavailable. The conditions to be checked can vary widely, but generally include anything from which it might be inferred or implied that the user is likely either Available or Unavailable or the equivalent. Such conditions can include, for example, whether or not a specified timeout for use of a keypad, trackwheel or other mechanical feature of the device has elapsed yet; whether or not a real-time application is in use; and preferably any one or more of a variety of other conditions, one further example being whether or not there are any unattended-to notifications such as an unanswered phone call, or a missed e-mail, SMS or other message.
Patent CA-2581676-A1 (CA)
Title: Storage implement and bag with movable storage implement
Inventor: SUDA KEIKO
IPC: A45C13/02
Filed: 2005-11-14
Abstract: A storing implement formed by fitting horizontal and vertical belts to a base plate and a pull-up storing tool so that the pull-up storing tool can be slid in the vertical direction. The implement can be stored in any bag and its storage parts can be pulled to the user's position.
Patent CA-2581801-A1 (CA)
Inventor: PRAGER ULRICH
IPC: A61C5/40
Filed: 2005-08-20
Abstract: A cannula (20) is disclosed, for the flushing of narrow tooth root canals, the cannula tube (46) of which comprises an axially long opening (66) at the end thereof. The length of the opening (66) can in practice be about 7 mm.
Patent CA-2584668-A1 (CA)
Inventor: BAECK ANDRE CESAR
IPC: C11D3/40
Filed: 2005-11-18
Abstract: The present invention relates to cleaning and/or treatment compositions comprising a dye conjugate, and processes of making and using such compositions. Such compositions can provide benefits such as an increase in the whiteness or blackness perception of a situs that is cleaned with such compositions.
Patent CA-2585079-A1 (CA)
Title: Therapeutic furopyrimidines and thienopyrimidines
Inventor: LIN TSU-HSING
IPC: A61K31/7076
Filed: 2005-10-28
Abstract: The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
Patent CA-2586203-A1 (CA)
Title: Irrigation/aspiration tip
Inventor: BOUKHNY MIKHAIL
IPC: A61B17/00
Filed: 2007-04-24
Abstract: An irrigation/aspiration tip having a shaft with a reduced or relatively small diameter with a distal tip having a relatively large diameter. The diameter of the shaft can vary depending upon the incision size preferred by the surgeon, and the diameter of the distal tip will vary depending upon the size of the phacoemulsification tip preferred by the surgeon.
Patent CA-2586422-A1 (CA)
Title: System comprising a coffee machine and a portion capsule
Inventor: TERNITE RUEDIGER
IPC: A47J31/40
Filed: 2005-10-31
Abstract: The invention relates to a coffee machine for brewing a hot drink, in particular, a coffee drink, by means of a portion capsule (20') with a capsule lid (22) and a capsule base (24), comprising a pressurised water device, a portion capsule holder (50) and a controller. The portion capsule holder (50) is provided with two relatively-displaceable puncture means (44, 54), which pierce the capsule lid (22) and the capsule base (24) on or after insertion of the portion capsule (20') in the portion capsule holder (50), such that hot water can enter the portion capsule (20') through the capsule lid (22) and the drink escapes through the capsule base (24) from the portion capsule (20').  The controller is provided for the provision of three differing pressures for the pressurised water, for example, for brewing espresso, white coffee and filter coffee. The capsule base (24) of the portion capsule can comprise a pre-weakened spot.
Patent CA-2587375-A1 (CA)
Title: Instant patch for dermal drug delivery
Inventor: WARNER KEVIN S
IPC: A61F13/00
Filed: 2005-11-11
Abstract: The present invention is drawn toward systems, devices, and methods of dermal drug delivery. The system can comprise a gel-triggering agent and a drug-containing composition including a drug and a gelling agent, wherein the drug-containing composition forms a soft, coherent solid when contacted with the gell-triggering agent. A cavity patch (10) is also included having an open cavity (18) configured to be closed at least in part by a skin surface (44).  The open cavity can be further configured to facilitate contact between the skin surface and the gel. The gel-triggering agent and the drug-containing composition can be positioned in the system such that they are kept isolated from one another until immediately before or during use.
Patent CA-2588580-A1 (CA)
Inventor: EBERHARDT HEIKO
IPC: B65D83/20
Filed: 2005-12-01
Abstract: In order to attain a pleasant noise in the case of a spray conduit (10), especially one that is integrated in a cap (7) that has a button (6) and a 90~  offset spray conduit (10), it is proposed that the spray conduit (10) have a texture on its inner surface that affects the discharge of a product so that a special discharge noise is achieved.
Patent CA-2589173-A1 (CA)
Inventor: HOPF CARSTEN
IPC: G01N33/68
Filed: 2005-11-25
Abstract: The present invention relates to methods for the screening of gamma secretase modulators, preferably inhibitors as well as to the use of Eph receptor inhibitors for the treatment of neurodegenerative diseases.