Patent SG-11201806783W-A (SG)
Title: Methods for treatment and prophylaxis of hiv and aids
Inventor: HAZUDA DARIA
IPC: A61P31/18
Filed: 2017-02-10
Abstract: Vehicle - m- 1.3 mpk +3.9 mpk - *-13 mpk fi 18.2 mpk W O 20 17 / 1395 19 Al 14 21 28 Day of Study FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/139519 Al 17 August 2017 (17.08.2017) WIPO I PCT (51) International Patent Classification: A61K 31/7076 (2006.01) A61P 31/18 (2006.01) (21) International Application Number: PCT/US2017/017283 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/294,576 12 February 2016 (12.02.2016) US 62/297,657 19 February 2016 (19.02.2016) US (71) Applicant (for all designated States except US): MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (72) Inventors; and (71) Applicants NZ, US only): HAZUDA, Dania [US/US]; 770 Surrmeytown Pike, West Point, Pennsylvania 19486 (US). MILLER, Michael D. [US/US]; 351 North Surrmeytown Pike, North Wales, Pennsylvania 19454 (US). GROBLER, Jay A. [US/US]; 770 Sumneytown Pike, West Point, Pennsylvania 19486 (US). NICOLL- GRIFFITH, Deborah Anne [CA/CA]; 261, rue Princip- ale, St-Basile-le-Grand, Quebec J3N 1H3 (CA). (74) Common Representative: MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] (54) Title: METHODS FOR TREATMENT AND PROPHYLAXIS OF HIV AND AIDS (57) : The present invention is directed to methods NH2 for inhibition of HIV reverse transcriptase, treatment of infec- tion by HIV, prophylaxis of infection by HIV, and the treat- OH < u 0) ment, prophylaxis and/or delay in the onset or progression of AIDS or ARC by administering a compound of structural Formula (I) or a pharmaceutically acceptable salt or co-crystal o thereof, wherein X is -F or -Cl, less frequently than once daily. SIV-Infected Rhesus Treated with EFdA Dosed on DO and D7 PO 11111111111111 0 111011111111111 010 11111 III 0111 0111 IR H 011110 11111111111 0111111 WO 2017/139519 Al MIDEDIMOMOIDEIR01013011100111111111111111111110111111111111 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))