Patent SG-11201407303S-A (SG)
Title: Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
Inventor: KANDULA MAHESH
IPC: C07D339/04
Filed: 2013-03-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/168021 A1 (51) International Patent Classification: C07C 57/48 (2006.01) C07C 233/49 (2006.01) C07C 233/87 (2006.01) C07D 339/04 (2006.01) A61K31/16 (2006.01) A61K31/385 (2006.01) A61K31/185 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/052239 21 March 2013 (21.03.2013) English English (30) Priority Data: 1779/CHE/2012 7 May 2012 (07.05.2012) IN (72) Inventor; and (71) Applicant : KANDULA, Mahesh [IN/IN]; Door No. 11- 61, Samalkot Mandal, East Godavari Dist, G.Medapadu 533 434, Andhra Pradesh (IN). (72) Inventor: KANDULA, Mahesh; Door No. 11-61, Samalkot Mandal, East Godavari Dist, Andhra Pradesh, G.Medapadu 533434 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) CJ o (54) Title: COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROMUSCULAR DISORDERS AND NEURODE- i-H GENERATIVE DISORDERS i-H o CJ (57) Abstract: The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of com­ pounds of formula (I), and methods for treating or preventing neuromuscular disorders and neurodegenerative diseases may be for­ mulated for oral, buccal, rectal, topical, transdermal, transmucosaf intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment or management of neuromuscular disorders and neurodegenerative diseases such as Parkin­ son's disease, scleroderma, restless leg syndrome, hypertension and gestational hypertension.