baber/WOPTO huggingface dataset:
Patent JP-H11511537-A (JP)
Title: 迅速結合空調継手
IPC: F16L37/30
Filed: 1995-02-23
Abstract: (57)【要約】
本発明は、加圧された冷媒流れ配管の対向する端（１１，１１′および１２，１２′）どうしを一緒に接続するための継手に関する。この継手は迅速接続装備を使用する。継手は、ハウジング（２０）内に装架される第１構造体（３５）と弁（５８）を備え、該ハウジングは、第２構造体（３６）と弁（９５）を保持する迅速接続装備（１０８）を有する。配管の接続が行われるとき、第２構造体（３６）がハウジング（２０）内に挿入され、ハウジング内の軸方向固定位置に保持される。そして、この固定位置にある第２構造体（３６）と弁（９５）に対して第１構造体（３５）と弁（５８）が軸方向に動かされていく。そこで軸方向に延在する第１弁（５８）が軸方向に延在する第２弁（９５）に係合し、この第２弁をこれの構造体に対して動かして閉じ位置から開き位置にさせる。第１構造体（３５）の軸方向への動きは、ハウジング（２０）上に装架された回転ハンドル（１２０）により作動されるカム（１２１）によって行われる。
Patent JP-2000509938-A (JP)
Title: ３次元観察
IPC: H04N13/04
Filed: 1998-02-16
Abstract: (57)【要約】
３次元観察方法において、二つの相違する画像（ＩＭ１，ＩＭ２）をスクリーン（ＳＣＲ）上に交互に表示する。二つの相違する画像（ＩＭ１，ＩＭ２）の各々を、観察者の右目（ＲＥ）又は左目（ＬＥ）に送る。多様な用途を許容するために、スクリーン（ＳＣＲ）上に、目に画像を送る必要がある表示（ＩＮＤ）を設ける。
Patent JP-2000512839-A (JP)
Title: 改良形始動回路を有するスイッチトモード電源
IPC: H02M1/00
Filed: 1998-03-16
Abstract: (57)【要約】
接地端子(ＧＮＤ)に対し電圧(Ｕ)を受信するように結合された第１の一次側端子及(１)び第２の一次側端子(2)を有する一次巻線(Ｐ)が設けられた変成器(ＴＲ)と、第２の一次側端子(2)と接地端子(ＧＮＤ)との間に結合されたスイッチング手段(ＳＭ)と、始動回路(ＳＴ)とを具えるスイッチトモード電源である。始動回路(ＳＴ)は第２の一次側端子(2)に結合されたドレイン電極、ソース電極及びゲート電極を有するノーマリオン形の電界効果トランジスタ(Ｔ)を具える。この始動回路(ＳＴ)を、特に、前記電界効果トランジスタ(Ｔ)のソース電極に結合された電圧安定器(ＶＳ)を具え、該電圧安定器(ＶＳ)が内部電源電圧を内部電源端子(ＶＩＮＳ)に供給するよう改良した。
Patent JP-H10500947-A (JP)
Title: イブプロフェンを経皮供給するためのマトリックスシステムおよびその製造方法
IPC: A61K31/194
Filed: 1995-05-10
Abstract: (57)【要約】
本発明は、イブプロフェンを経皮供給するための自己接着性経皮供給マトリックスシステムに関し、（ａ）ガラス転位点が−７０〜−１０℃の接着性アクリレート共重合体５５〜７５重量部、（ｂ）ガラス転位点が２０〜８０℃のカチオン性アクリレート共重合体５〜１５重量部、（ｃ）遊離酸の形態のイブプロフェン５〜１５重量部、および（ｄ）フタル酸ジエチル１０〜２５重量部を含む。本発明はさらに上記マトリックスシステムの製造方法に関する。
Patent JP-H11503318-A (JP)
Title: 酵母中で興味あるタンパク質を発現するための新規なプロモーター
IPC: C12N15/81
Filed: 1996-04-05
Abstract: (57)【要約】
酵母のゲノムDNAから単離され、転写プロモーター活性を有する新規な核酸フラグメント、並びにそれを含む発現カセット、ベクターおよび宿主細胞が開示されている。商業的または治療的に有用なポリペプチドを産生するための該フラグメントの使用も開示されている。
Patent JP-H09506112-A (JP)
Title: セファロスポリン化合物およびその製造方法
IPC: C07D501/46
Filed: 1995-05-22
Abstract: (57)【要約】
次の式（Ｉ）の新規なセファロスポリン化合物は、グラム陽性菌とグラム陰性菌および種々の耐性菌に対して輻広く強い抗菌力を示す：
Patent JP-2000507967-A (JP)
Title: 環状スルホン誘導体
IPC: A61K45/00
Filed: 1997-12-18
Abstract: (57)【要約】
式（Ｉ）（式中、ｎ、Ｘ、ＹおよびＡｒは上記の通りである）の化合物は、関節炎、癌、組織潰瘍、筋肉崩壊、再狭窄、歯周病、表皮水泡症、強膜炎ならびにマトリックスメタロプロテイナーゼ活性を特徴とするその他の疾病、ＡＩＤＳ、敗血症、敗血症ショックおよびＮＴＮＦの生成を含むその他の疾病を治療する、
Patent JP-2002509623-A (JP)
Title: 写真カラー現像増し液濃縮物
IPC: G03C5/26
Filed: 1998-01-29
Abstract: (57)【要約】
写真的に不活性な単一環の複素環式アミドを含む一液型多相の濃縮されたカラー現像増し液およびその製造方法。この増し液濃縮物は単一のユニットに包装され、希釈によりすぐ使用できる写真材料用の増し液を形成する。この濃縮された増し液は現像主薬が上相中に保持されて、通常は高アルカリ性の下相中で生じる劣化から保護される一液型多相の濃縮物として特徴づけられる。
Patent JP-2001527490-A (JP)
IPC: B65C9/00
Filed: 1998-01-29
Abstract: A method and apparatus for labeling containers allows labeling of containers by wrap around labeling without applying an adhesive on the leading edge of the label. Labels are held on a label drum and moved into a label applying position while containers are fed into the label applying position. Air is blown from a first position on the label drum onto the leading edge of the label at an angle to the label drum surface and in a direction backward along the label from the leading edge to force the leading edge of the label against the container, while also minimizing the laminar flow of air under the label. After the leading edge of the label has engaged the container, air is blown from a second position on the label drum spaced from the first position onto the label and container at an angle to the label drum surface to maintain a laminar flow of air over the label and maintain the label tight against the container during container rotation. The leading edge is maintained on the container by wet adhesion or by air which is blown onto the label and container from first and second angled positions on the side opposite the label drum. Air can also be blown from a third position on the label drum spaced from the first and second positions onto the leading edge of the label after the container has rotated almost 360 degrees to maintain the label tight against the container during the final part of the wrapping process.
Patent JP-H11504935-A (JP)
Title: ギ酸の複塩を含有する製品の製造方法
IPC: A23K1/16
Filed: 1996-05-10
Abstract: (57)【要約】
本発明はギ酸の複塩を含有する製品を製造する方法に関するものである。カリウムの水酸化物、炭酸塩、重炭酸塩またはギ酸塩、ナトリウムの水酸化物、炭酸塩、重炭酸塩またはギ酸塩、セシウムの水酸化物、炭酸塩、重炭酸塩またはギ酸塩、またはアムモニウムホルメートまたはアンモニアをギ酸と４０〜１００℃で混合し、この混合物を冷却し、遠心分離しする。塩を含有する濾液は集める。フィルターケーキは乾燥／混合装置に移送され、そこで他の複塩および／または乾燥剤と混合されてもよい。
Patent JP-H11505198-A (JP)
Title: パワーアシストされた液圧式ステアリングシステム
IPC: B63H25/12
Filed: 1996-05-20
Abstract: (57)【要約】
ステアリングホイール（２２）をステアリングアクチュエータ（２６）に連結するためハウジングを通って延在するステアリングリンク機構（２４）と、電気的に作動する液圧ポンプ（１２）と、作動液のタンク（１４）を有するタイプのパワーアシストされた液圧式ステアリングシステム（１０）。当該ステアリングシステムは、上記ステアリングアクチュエータ（２６）に連結したブーストシリンダ（３２）と、上記ポンプ（１２）とタンク（１４）とを当該ブーストシリンダ（３２）に流体連結する液圧スプールバルブ（３０）、ポンプ（１２）に連結されたスイッチ（３４）を有してなる。スプール（４０）はパワーアシスト限界を確立するセンタリングスプリング（４２）によってニュートラル位置に片寄らされる。ステアリングホイール（２２）の回転によってステアリングアクチュエータにもたらされる操舵力がパワーアシスト限界よりも小さい場合、ポンプ（１２）がスイッチオフでスプール（４０）はニュートラル位置に維持される。もたらされた操舵力がパワーアシスト限界よりも大きい場合、リンク機構ハウジング（２４）はスプール（４０）を引き込み位置に押しやリそれによってポンプをスイッチオンとし、パワーアシストストロークを介してブースとシリンダ（３２）とステアリングアクチュエータ（２６）を駆動する。
Patent JP-H11506369-A (JP)
Title: 液流推進式カテーテル
IPC: A61M25/00
Filed: 1996-05-31
Abstract: (57)【要約】
カテーテル（１０）はマニホールド（１２）およびこれに連結された基端シャフト部（１６）を含む。先端シャフト部（１８）は基端シャフト部（１６）の基端部に結合され、基端シャフト部（１６）に比べて可撓性に富む。ファイバー製の補強奏（２６）が先端シャフト部（１８）の周囲に配設される。
Patent JP-2002514993-A (JP)
Title: 衛生的な飲料缶用蓋
IPC: B65D17/34
Filed: 1998-02-26
Abstract: (57)【要約】
衛生的な飲料缶用蓋(20)において、蓋中央のプラットフォーム(31)が、缶(10)のリム(17)下より上昇させたプルタブ(30)を含み、プルタブは従来の飲料缶と同様に、缶のリムに近接して、またはその上に配置される。中央のプラットフォームの直径は、缶本体外側からプラットフォーム縁部への追加の空間を設けるためにすぼまっている。プルタブは中央のプラットフォームの中間に配置され、それによってプルタブの端部は、缶が容易に開けられるように中央のプラットフォームの縁に位置する。上昇させた中央のプラットフォームと蓋の設計は、人の唇が、ごみが溜まるおそれのある蓋の縁部に沿った溝(21)と接触するのを防ぐ。もう一つの特徴は、プラットフォーム上の上昇させたリムが、余分な飲料が缶内部に還流するように、内側に還流用の傾斜部(47)を有することである。
Patent JP-2001514752-A (JP)
Title: 果実及び野菜の成熟又は硬さを評価するための方法及び装置
IPC: G01N33/02
Filed: 1998-03-10
Abstract: (57)【要約】
その成熟を評価するべく果実及び野菜をテストするための装置は、ベローズのための支持筒（３２）を介して加圧空気と真空の付与によって拡張、収縮可能で、かつ、テスト対象の果実又は野菜を軽打するためのインパクタ（３３）を取り付けたベローズ（３０）を有するインパクタ装置（２８）を有する。前記インパクタは、前記ベローズ（３０）に対して相対移動可能な内部スラグを有し、これによって、ベローズが、拡張して、そのノーズ片（３６）がテストされるべきアイテムの表面に接触して停止した時、前記スラグは、それ自身の推進力によって、前記ノーズ片に形成された開口部（３５）を通過して移動を続けて、前記アイテムの表面を軽打する。前記スラグは、このスラグが、アイテムに対して軽打された時に、その反動力に対応するパルスとしての電気出力信号を発生する力変換器を内蔵し、このパルスが処理されて、前記果実の成熟を表わす信号が作り出される。
Patent JP-2001516238-A (JP)
IPC: A61J1/00
Filed: 1998-03-13
Abstract: There is disclosed a new self-rehydrating container for the production of solutions or suspensions substantially free or undesirable micro-organisms. The container is divided into at least two compartments by at least a non-permanent seal bonding the opposite walls of said container, the walls of the container surrounding at least a first compartment being watertight, the walls of the container surrounding at least one portion of at least a second compartment being semi-permeable, a water soluble or suspendible product or a concentrated solution or suspension thereof being retained in said second compartment and a water soluble or suspendible product, a drug, a nutritional suspension or powder to be put into solution or suspension is retained in said first compartment. This new self-rehydrating container allows the production of pure solutions of very low molecular weight solutes, of accurately dosed solutions, prevents the oxidation or hydrolysis of the material to be rehydrated and prevents the contamination of the rehydrated material by eventual residual bacteria.
Patent JP-H11509910-A (JP)
Title: 内燃機関の制御方法及び装置
IPC: F02D41/10
Filed: 1997-03-06
Abstract: (57)【要約】
車両内燃機関の制御方法及び装置が記載され、この方法及び装置において、目標トルク値が与えられ、この目標トルク値が少なくとも２つの目標値に分割され、該分割されたこれらの目標値は、内燃機関の充填量と、迅速なトルク変化をもたらす少なくとも１つの他の出力パラメータとの設定のために使用され、ここで少なくとも１つの運転状態において少なくとも２つの目標値が異なる値を有している。
Patent JP-2001522392-A (JP)
Title: 長い匂い寿命を有する香料
IPC: A61K6/00
Filed: 1998-04-23
Abstract: (57)【要約】
本発明はパヒュームまたはファインフラグランス組成物に関係し、特に芳香素材成分を徐々に放出し、それによって使用者に持続的芳香レベルをもたらすプロ−アコード化合物類を含んでなる、香水、コロン、オー・ドゥ・トワレ、およびアフターシェーブローションに関するものである。典型的には、プロ−アコード類は加水分解によって２種類以上の芳香素材を放出するオルトエステル類、ケタール類、アセタール類、オルトカルボネート類を含んでなる。本発明は、第一のプロ−アコード含有貯蔵器および第二の芳香素材貯蔵器および前記芳香物質を混合、適用するための手段を含んでなる製品にも関係する。
Patent JP-2001507367-A (JP)
Title: 付着性コポリマーを含むパーソナルケア組成物
IPC: A61Q17/04
Filed: 1998-04-24
Abstract: (57)【要約】
本発明は、パーソナルケア組成物に関する。これらの組成物は、付着性コポリマーと、水、エタノール、ｎ−プロパノール、イソプロパノール、アセトン、プロピレングリコール及びこれらの混合物からなる群より選択された該コポリマーのための溶媒とを含む。当該組成物は、乾燥すると、約０.５ｋｇｆ／ｍｍ 2 よりも大きい凝集強度、約０.５５ｋｇｆｍｍ／ｍｍ 3 を越える単位容量あたりの総エネルギー吸収及び約７０００ergsを越える衝撃強度を有する。また、ここで定義された除去能方法論によって決定された０から約３.５（０から４のスケール）の髪のこわさ及び０から３.５（０から４のスケール）の髪フレーキング値によって定義された髪からの改良された除去能を有する本発明のエアヘアスプレー実施形態が好ましい。
Patent MX-161271-A (MX)
Inventor: WEBER HAROLD J
IPC: G03G15/01
Filed: 1983-02-15
Abstract: Electrophotographic imaging apparatus, particularly for color proofing, is provided for normal daylight operation including a light-tight housing having a framework mounting plural spaced functional processing stations for charging, imaging, toning, transfer and, optionally, cleaning, all interior of the housing. A platen assembly mounting an electrophotographic member is translated along a linear path, the assembly being guided by a rail and a track secured along the entire length of the framework. A copyboard is disposed below the carriage within the imaging station and carries a transparency. The electrophotographic member is translated past the charging station for charging same and brought to the imaging station where the copyboard is raised, to establish an intimate engagement with the member established and exposed to an interior disposed radiant energy source. After exposure, the copyboard is lowered and the member translated to the toning station where one of plural available toning modules has been raised to intercept the platen whereby to establish a toning gap for toning with liquid toner carried by said one module during passage past said module. The member next is translated to the transfer station for transfer to a pre-wet sheet of transfer medium. A registration system is provided at both imaging and transfer stations to assure registration between the member and the transparency on the one hand and the member and the transfer medium on the other hand at the respective station whereby all functional tolerance relationships being maintained independent of the framework.
Patent MX-158082-A (MX)
Inventor: GOEBBEL KONRAD
IPC: F01K23/06
Filed: 1984-05-29
Abstract: Medium-load power generating plant with an integrated coal gasification plant, with a gas-turbine power generating plant part connected to the coal gasification plant, with a steam generating plant part connected to the raw-gas heat exchanger installation of the coal gasification plant, and with a methanol synthesis plant. The methanol synthesis plant has parallel-connected modules and is connected to the gas-turbine power generating plant part via a central purified gas distribution system which includes a purified gas continuous-flow interim storage plant connected parallel to the pure gas supply line and is connected on the gas side to the raw-gas heat exchanger installation.
Patent NZ-204653-A (NZ)
Title: N-fluoroalkylene-dioxy-phenyl-n1-benzoyl-(thio)-ureas and pesticidal compositions
Inventor: MARHOLD A
IPC: C07D319/20
Filed: 1983-06-21
Abstract: Compounds of the formula   <IMAGE>   in which R1 is hydrogen, halogen or alkyl, R2 is halogen, alkyl or alkylthio, X is oxygen or sulphur, and Y is hydrogen, halogen, alkyl or halogenoalkyl, which possess pesticidal activity.
Patent NZ-220397-A (NZ)
Title: Apparatus for supplying liquid filled cushions to packaging machine
Inventor: BRIE GEORGES
IPC: B65B35/10
Filed: 1985-06-24
Abstract: Welding and cutting process in which the bag is disposed in a holding unit (107) supporting and positioning it, and is composed of a side plate (108), a stop plate (109), and a closing angle member.
Patent NZ-238022-A (NZ)
Title: Indole derivatives and pharmaceutical compositions
Inventor: SALLMANN ALFRED
IPC: A61K31/40
Filed: 1991-05-02
Abstract: Novel trisubstituted indole compounds of formula   <IMAGE> (I) +TR <IMAGE>  wherein R is straight-chain C2-C4alk-1-en-1-yl, and their salts can be used as pharmaceutical active ingredients and can be manufactured in a manner known per se.
Patent NZ-238340-A (NZ)
Title: Preparation of 3-(methylamino)-piperidine derivatives
Inventor: GODEK DENNIS M
IPC: C07B57/00
Filed: 1991-05-30
Abstract: Novel processes are disclosed for the preparation and resolution of substituted piperidines of formula (I), wherein R<1> and R<2> are defined as below, and related compounds, as well as novel intermediates used in such processes.
Patent NZ-248359-A (NZ)
Title: 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline derivatives and pharmaceutical compositions
Inventor: SUM PHAIK-ENG
IPC: A61P31/04
Filed: 1993-08-09
Abstract: The invention provides compounds of formula I: <CHEM> wherein X, R and R<1> are defined in the specification. These compounds are useful as antibiotic agents.
Patent NZ-250868-A (NZ)
Title: Bale tie; steel wire bent to form two marcelled portions which have sinusoidal undulations; package using such ties; method of marcelling wire; tension measurement
Inventor: VELAN GEORGE M
IPC: B65D85/07
Filed: 1994-02-14
Abstract: For tying a compressed bale (10,50) tending to expand primarily along a major axis, a bale tie (30,60) made preferably from steel wire or alternatively from steel strap is bent to form two marcelled portions (40,70), which are characterized by sinusoidal undulations, which are oriented so as to be generally parallel to the major axis, and along which the tie can straighten to absorb tensile forces. A joint (34,64) is formed at the opposite ends of the tie. Where bent to form the marcelled portions (40,70), the tie has an ultimate strength less than the ultimate strength of an undeformed portion of the tie but more than the ultimate strength of the joint. An apparatus for forming a wire with a marcelled portion comprises upper rolls (130) and lower rolls (140), which are mounted rotatably and respectively on an upper block (108) and a lower block (110). The upper block is mounted pivotally to the lower block. <IMAGE>
Patent NZ-298144-A (NZ)
Title: Quinuclidine derivatives having muscarinic receptor antagonistic activity and medicaments therefrom
Inventor: TAKEUCHI MAKOTO
IPC: C07D453/02
Filed: 1995-12-27
Abstract: Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. <CHEM> The compound has an antagonistic effect on muscarinic M3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.
Patent NZ-306668-A (NZ)
Title: Disposable paper product with indicator means comprising a pattern of discrete elements visible when the product is wet
Inventor: STEINHARDT MARK JOHN
IPC: D21H27/40
Filed: 1996-03-27
Abstract: The specification describes disposable paper products, such as paper toweling or tissues. The paper products have an indicator which is laid in a discontinuous or combination discontinuous/continuous pattern. The indicator gives a visually recognizable signal to a user that desirable properties of the disposable paper product are maintained, even after the disposable paper product has become wetted with a substantially transparent aqueous liquid. The wet gray scale difference for the disposable paper product is at least 64 gray scale units when the disposable paper product is wetted with a clear aqueous liquid.
Patent NZ-314661-A (NZ)
Title: An apparatus for setting baited hooks of a fishing line beneath the surface of the water from a trolling vessel comprising a tube
Inventor: BARNES PAUL DANIEL LOUIS
IPC: A01K91/18
Filed: 1998-07-23
Abstract: pparatus 1 for serial baited hook deployment from a vessel for pelagic fishing comprises a chute in the form of a conduit 2 deployed from a vessel.  A means is adapted to deploy chute from such a vessel whereby when deployed in use the chute has above the water level and accessible from the vessel a baited hook receiving end and below the water level, a baited hook deployment end.  The chute can convey a baited hook in conduit form 2 from the receiving end to the deployment end.  The chute has a lengthwise extending opening or slot 20 which enable a baited hook to move into and down conduit form 2 with its snood or trace extending out of conduit form 2 throughout the movement of the baited hook down to the release of the baited hook at or below the water level from the deployment end or from slot 20 adjacent the deployment end.  Using conduit form 2 during such lowering of the baited hook protects the baited hook from bird strike.
Patent NZ-328452-A (NZ)
Title: Carton feed opening wheel assembly having suction cups and cooperating with vacuum conveyor belts
Inventor: REUTELER URS
IPC: B31B5/80
Filed: 1997-03-25
Abstract: A carton feed opening wheel assembly apparatus 5 for opening carton blanks 22 into preformed cartons on a packaging machine 7 is disclosed.  The apparatus 5 has a pair of spaced and generally parallel endless vacuum conveyor belts 24 moving along a path of travel from a magazine assembly 15 to a transport conveyor 17, and a carton opening wheel 30 positioned on the packaging machine 7 with respect to the vacuum conveyor belts 24 for engaging the top portion of an unopened carton blank 22 being moved on the vacuum conveyor belts 24 toward the transport conveyor 17.  The carton opening wheel 30 has at least one suction cup 39 supported thereon for engaging the top portion of the carton blank 22 at a speed and direction substantially the same as the speed and direction of the unopened carton blank 22 moving on the vacuum conveyor belts 24.  Thereafter, the speed of the suction cup 39 in the direction of the path of travel is retarded with respect to the speed of the bottom portion of the carton blank 22 being moved on the vacuum conveyor belt as the suction sup is simultaneously moved perpendicularly away from the vacuum conveyor belts so that the carton blank is opened, whereupon the opened carton is then passed to the carton transport conveyor.  The wheel assembly includes drive means for rotating the frame of wheel 30 about its central shaft 35 and may include a control processor having an electronic cam profile programmed therein to control the speed of the drive means with respect to the speed of the vacuum conveyor belts.
Patent NZ-334908-A (NZ)
Title: 3-imino-4-oxo-1,7-dioic acid (7-N-hydroxy) diamide derivatives characterised by the presence of an oxymethyl group on the 6-position for supression of TNF and treatment of inflammation
Inventor: KOTTIRSCH GEORG
IPC: C07C259/06
Filed: 1997-09-30
Abstract: Hydroxamic compounds belonging to the family of 3-imino-4-oxo-1,7-dioic acid (7-N-hydroxy) diamides characterised by the presence of an oxymethyl group on the 6-position are disclosed. Preferred compounds have formula described. The present compounds are useful in pharmaceuticals, e.g. for the suppression of TNF release and the treatment of autoimmune and inflammatory diseases, e.g. multiple sclerosis and rheumatoid arthritis, and possess an improved bioavailability. Also disclosed are processes for the preparation of these compounds, as well as intermediates thereof and pharmaceutical compositions containing them.  Wherein;  R1 is a substituent of A-(O-(CR5H)n)m-O-CH2- ; wherein n is 1, 2, 3 or 4; m is 0, 1, 2 or 3; each R5 is independently H, C1-10 (optionally hydroxy-, C1-6 alkoxy-, amino-, C1-6alkylamino-, thiol-, C1-6alkylmercapto- or protected hydroxy, amino or thiol substituted) alkyl, C2-6alkenyl, C6-14(optionally hydroxy-, C1-6alkoxy-, amino-, C1-6alkylamino-, halo- or cyano- substituted) aryl, or C6-14 (aryl) C1-6alkyl;  A is hydrogen, C1-10alkyl, C6-14aryl, C6-14aryl(C1-6alkyl), (C6-14aryl)carbonyl, or (C1-10alkyl)carbonyl;  R2 is C3-12alkyl, C3-12alkenyl, C3-7(optionally hydroxy-, C1-6alkoxy-, amino-, or C1-6alkylamino- substituted) cycloalkyl, C5-14aryl, or C5-14aryl(C1-6alkyl), wherein aryl groups are optionally substituted by hydroxy-, C1-6alkyl-, C1-6 alkoxy-, amino-, halo or cyano-;  R3 is C1-10(optionally hydroxy- or C1-6alkoxy- amino-, C1-6alkylamino-, thiol-, C1-6 alkylmercapto- or protected hydroxy-, amino- or thiol- substituted) alkyl, C6-14(optionally hydroxy-, C6-14aryloxy-, or C1-6alkoxy-, amino-, C1-6alkylamino-, halo-, or cyano- substituted)aryl, or indolylmethyl;  R4 is methyl, pyridyl, or a substituent of formula X-Y- wherein X is morpholino, pyridyl or aryl, and Y is C1-12alkylene in which up to four of the methylene (-CH2-) units are optionally replaced with -CO-, -NH-, -SO2- or -O-.
Patent NZ-335080-A (NZ)
Title: Use of dual non-selective beta-adrenoceptor and alpha1-adrenoceptor for inhibiting stress activated protein kinases(SAPK)
Inventor: WANG XINKANG
IPC: A61K31/00
Filed: 1997-10-09
Abstract: *[P335080  The use of a dual non-selective ß-adrenoceptor and á1-adrenoceptor antagonist in the manufacture of a medicament for inhibiting stress-activated protein kinases (SAPK), like SAPK initiated apoptosis in cardiac cells, where the antagonist has the formula 1; R7-R13 are independently H or OH; A is formula II R1 is H, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is H, lower alkyl of 1-6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is H, lower alkyl of up to 6 carbon atoms; R4 is H, lower alkyl of up to 6 carbon atoms, or when X is O, R4 together with R5 can represent -CH2-O-; X is a single bond, -CH2, oxygen or sulphur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, OH, lower alkyl of up to 6 carbon atoms, -CONH2- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkylsulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R5 and R6 together represent methylenedioxy; and pharmaceutically acceptable salts thereof.
Patent NZ-335397-A (NZ)
Title: Immunostimulatory unmethylated CpG dinucleotides
Inventor: GEORGE WEINER
IPC: C12N15/117
Filed: 1997-10-30
Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.  The unmethylated CpG dinucleotides having a formula:  5' N1X1CGX2N2 3'  wherein at least one nucleotide separates consecutive CpGs; X1 is adenine, guanine or thymine; X2 is cytosine or thymine; N is any nucleotide and N1 + N2 is from 0-26 bases with N1 + N2 does not contain a CCGG quadmer or more than one CCG or CGG trimer; and the nucleic acid is 8-30 bases in length.
Patent NZ-336635-A (NZ)
Title: Process and kit for permeabilizing erythrocytes, and immuno-marking foetal erythrocytes
Inventor: VAN AGTHOVEN ANDRE
IPC: G01N33/72
Filed: 1999-07-07
Abstract: Provided is a process for permabilising erythrocytes in vitro characterised in that the erythrocytes are subjected successively to the action of a)	a fixing agent containing an aliphatic aldehyde, an oligosaccharide and optionally a sulfated poysaccharide in preferably an isotonic or hypertonic medium with a pH of between 4 and 7; and b)	a permeabilising agent containing a detergent and an oligosaccharide preferably with a pH of 5 to 6; and optionally c)	after fixation and permeabilisation, the erythrocytes are washed using a washing agent to eliminate the detergent; and optionally the erythrocytes are reacted with two antibodies against two foetal antigens which are expressed independently on the erythrocyte. Also provide is a suitable kit for permeabilising erythrocytes comprising agents a) and b) above.