Patent SG-11201407945S-A (SG)
Title: Cladosporium peptides
Inventor: HAFNER RODERICK PETER
IPC: C12N9/64
Filed: 2013-05-30
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/179044 A2 (51) International Patent Classification: C07K14/37 ( 2006.01) A61K 39/35 (2006.01) CI2N 9/64 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/GB2013/051440 30 May 2013 (30.05.2013) English English (30) Priority Data: 1209862.0 1 June 2012 (01.06.2012) GB (71) Applicant: CIRCASSIA LIMITED [GB/GB]; The Ox­ ford Science Park, Oxford, Oxfordshire OX4 4GA (GB). (72) Inventors: HAFNER, Roderick Peter; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Ox­ fordshire OX4 4GA (GB). LAIDLER, Paul; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Ox­ fordshire OX4 4GA (GB). HICKEY, Pascal; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Oxfordshire OX4 4GA (GB). LARCHE, Mark; Depart­ ment of Medicine HSC, 4H20 McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5 (CA). (74) Agent: WOODS, Geoffrey Corlett; 14 South Square, Gray's Inn, London, Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a)) CJ •t •t o o\ l> i-H cn i-H o CJ o & (54) Title: CLADOSPORIUM PEPTIDES (57) Abstract: Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and comprise: (I) the amino acid sequence: (a) GGYKAAVRPTMLE (SEQ ID NO : 35; Cla35), (b) AE V YQKLK SLTKK (SEQ ID NO: 31; Clal6), (c) VAITYASRAQGAE (SEQ ID NO: 32; Cla25), (d) GHHFKERGT - GSLVIT (SEQ ID NO: 33; Cla26), or (e) ANYTQTKTVSIRL (SEQ ID NO: 34; Cla29); or (II) a T cell epitope-containing variant sequence which is a said amino acid sequence (I) having up to six amino acid modifications, each of which is independently a dele - tion, substitution or insertion.