Patent SG-11201809674Q-A (SG)
Title: Adenine derivatives as protein kinase inhibitors
Inventor: SURLERAUX DOMINIQUE
IPC: C07D473/34
Filed: 2017-05-04
Abstract: Filing Language: (26) Publication Language: (30) Priority Data: 16305530.4 04 May 2017 (04.05.2017) Published: English with international search report (Art. 21(3)) English 04 May 2016 (04.05.2016) EP (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 November 2017 (09.11.2017) WIP0 I PCT omit Ill Hot °inn Oil Oil Imo oimIE (10) International Publication Number WO 2017/191297 Al (51) International Patent Classification: CO7D 473/34 (2006.01) A61P 35/00 (2006.01) A61K 31/52 (2006.01) (21) International Application Number: PCT/EP2017/060730 (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BCI PHARMA [FR/FR]; Impasse plan de maule 63, 34790 Grabels (FR). (72) Inventors: SURLERAUX, Dominique; 26 me Debussy, 34980 Saint Gely du fesc (FR). AMIABLE, Claire; 127 rue des razeteurs - apt 29, 34570 Montpellier (FR). GUILLON, Remi; 88 mail George Sand, 34570 Montamaud (FR). (74) Agent: GEVERS PATENTS; Holidaystraat 5, 1831 Diegem (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = (54) Title: ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 1 3 C 1 2 [heterocycle] (I) R 1 1 R 3 , _ R 4 . z k m (57) : The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the N- oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, formula (I) wherein A, R1, R2, R3, R3 , , R4, R4 , , X, Y, Z, T are as defined in the claims. The invention further relates to an in vitro method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, inflammatory disorders, cardiovascular diseases, viral induced diseases, circulatory diseases, fibro-proliferative diseases and pain sensitization disorders.