Patent EP-0054507-B1 (EP)
IPC: A61P25/20
Filed: 1981-12-15
Granted: 1988-02-17
Abstract: 3-substituted beta-carbolines of the formula <CHEM>  wherein R<A> is H, F, Cl, Br, I, NO2, CN, CH3, CF3, SCH3, NR<1><6>R<1><7> or NHCOR<1><6>, wherein R<1><6> and R<1><7> are the same or different and each is hydrogen or alkyl, alkenyl or alkynyl each of up to 6 C-atoms, aralkyl or cycloalkyl each of up to 10 C-atoms, all of which groups for R<1><6> and R<1><7>, except for H, can optionally be substituted by halogen, hydroxy, SH, SR<2><3>, COOR<2><3>, nitrilo, CONR<2><3>R<2><4>, CHOR<2><3>OR<2><4> or CHSR<2><3>SR<2><4>, wherein R<2><3> and R<2><4> are the same or different and each is hydrogen or a lower alkyl of up to 3 C-atoms, or wherein R<1><6> and R<1><7> together form a saturated or unsaturated 3-7 membered heterocyclic ring, optionally substituted with a lower alkyl group of up to 3 C-atoms, =S, =O, OR<2><3>, SR<2><3> or NR<2><3>R<2><4>, wherein a C-atom in the hetero ring may optionally be replaced by S, O or NR<2><3>,  wherein, throughout, R<2><3> is as defined above; <CHEM> wherein R<2><3> and R<2><4> are the same or different and each is as defined above; or R<A> is CHR<3><3>-OR<3><9> wherein R<3><3> and R<3><9> are the same or different and R<3><3> is hydrogen or lower alkyl of up to 3 C-atoms and R<3><9> is hydrogen, lower alkyl of up to 3 C-atoms or    @R<3><3>; or R<A> is OR<1><8> wherein R<1><8> is alkyl, aryl or aralkyl each of up to 12 C-atoms;  or R<A> is C IDENTICAL  CR<3><5>, wherein R<3><5> is hydrogen, lower alkyl of up to 3 C-atoms, aryl of up to 12 C atoms, or CHR<3><3>R<3><0>, wherein R<3><3> is as defined above and R<3><0> is halogen, OR<4><0> or NR<4><1>R<4><2>, wherein R<4><0> is hydrogen, lower alkyl of up to 3 C-atoms, or C4 or 5-alkylene thereby forming a 5- or 6-membered heterocyclic ring containing O and wherein R<4><1> and R<4><2> are the same or different and each is hydrogen or lower alkyl, or together are C4 or 5-alkylene forming a ring with the N-atom, <CHEM>  wherein R<2><3> and R<2><4> are as defined above; or R<A> is COOR<2>, SR<2> or SO2R<2>, wherein R<2> is alkyl of up to 6 C atoms; or R<A> is SO2 NR<2><1>R<2><2> wherein R<2><1> and R<2><2> each is H or lower alkyl, and wherein each compound may contain 1-4 identical or different non-H R<A> groups; R<C> is hydrogen, lower alkyl, alkoxyalkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms, aralkyl of up to 8 C-atoms, or (CH2)nOR<2><0> wherein R<2><0> is alkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms or aralkyl of up to 8 C-atoms and n is an integer of 1 to 3;  Y is oxygen, two hydrogen atoms or NOR<1>, wherein R<1> is hydrogen, lower alkyl, aryl or aralkyl of up to 6 C-atoms, COR<2>, wherein R<2> is lower alkyl of up to 6 C-atoms, or Y is CHCOOR<3>, wherein R<3> is hydrogen or lower alkyl or Y is NNR<4>R<5>, wherein R<4> and R<5> can be the same or different and each is hydrogen, lower alkyl, C6-10-aryl, C7-10-aralkyl or CONR<6>R<7>, wherein R<6> and R<7> can be the same or different and each is hydrogen or lower alkyl or R<4> and R<5> together with the connecting N-atom, for a 5- or 6-membered heterocyclic ring which optionally may also contain an O-atom or up to 3 N-atoms and which optionally may be substituted by a lower alkyl group; Z is hydrogen, or alkoxy or aralkoxy each of up to 10 C-atoms and each optionally substituted by hydroxy, or Z is alkyl of up to 6 C-atoms, C6-10-aryl or C7-10-aralkyl each of which may optionally be substituted by a COOR<8>- or a CONR<9>R<1><0> group, wherein R<8> is alkyl of up to 6 C-atoms, and R<9> and R<1><0>, be the same or different and each is hydrogen or alkyl to 6 C-atoms; or Z is NR<9>R<1><0>, wherein R<9> and R<1><0> are as defined above or Z is NR<1><1>CHR<1><2>R<1><3>, wherein R<1><1> and R<1><2> each is hydrogen or together form N=C double bond,  wherein R<1><3> is C1-10-alkyl or NR<1><4>R<1><5>, wherein R<1><4> and R<1><5> are the same or different and each is hydrogen, OH or alkyl or alkoxy each of up to 6 C-atoms, or wherein R<1><2> and R<1><3> together are oxygen, in which case, R<1><1> is hydrogen;  or Z is COOR<2> wherein R<2> is as defined above; or Y and Z, together with the connecting C-atom, may form a 5- or 6-membered heterocyclic ring which contains an O-atom, adjoining O- and N-atoms or up to 4 N atoms and which optionally may be substituted by a lower alkyl group, hydroxy or oxo have valuable psychotropic properties which make them useful for example as tranquilizers.