baber/WOPTO huggingface dataset:
Patent IL-130036-A0 (IL)
Title: Survivin a protein that inhibits cellular apoptosis and its modulation
IPC: G01N33/68
Filed: 1997-11-20
Abstract: The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isolated Survivin encoding nucleic acid molecules, methods of isolating other members of the Survivin family of proteins, methods for identifying agents that block Survivin mediated inhibition of cellular apoptosis, methods of using agents that block Survivin mediated inhibition or Survivin expression to modulate biological and pathological processes, and methods of assaying Survivin activity.
Patent IL-131099-A0 (IL)
Title: Novel compounds and perfume compositions containing them
IPC: C07C43/188
Filed: 1999-07-26
Abstract: The invention is directed to novel compounds selected from the class of compounds having the structural formulae <CHEM> wherein the cyclohexane moiety with the dotted circle represents either a cyclohexane ring or a benzene ring, n represents an integer with the value 1, 3, or 4, m represents an integer with the value 1 or 2, R1, R2, R3, R4 and R5, represent hydrogen or a lower alkyl group, and the total carbon number of R1, R2, R3, R4 and R5 combined is eight or less.
Patent IL-166784-A0 (IL)
Title: New purine derivatives
IPC: A61K31/52
Filed: 2005-02-09
Abstract: The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
Patent IL-169890-A0 (IL)
Title: Improvements in or relating to safety covers for electric sockets and the like
IPC: H01R13/639
Filed: 2005-07-26
Abstract: A detachable cover for a socket or switch comprises a frame (CF) arranged to extend around the perimeter of a faceplate of the socket or switch and a cover panel (CP) connected to the frame (CF) for movement between open and closed positions. The frame (CF) comprises at least two frame members (CF1, CF2) capable of being arranged to extend around the faceplate and secured in place by locating behind the faceplate. The frame members (CF1, CF2) are releasably connected together on each side of the frame (CF) by interengageable mating formations (CF', CF") that clip together.
Patent RO-128905-A0 (RO)
Title: Ecological process for optimally exploiting the biologically-active substance potential of trigonella foenum graecum and cosmetic products with estrogen-mimetic effect prepared thereby
Inventor: ZGLIMBEA LENUTA
IPC: A61K8/63
Filed: 2012-06-29
Abstract: The present invention relates to a process intended for the optimal exploitation of the biologically-active substance potential of Trigonella foenum graecum (fenugreek) to obtain dermato-cosmetic phytotherapeutic products with estrogen-mimetic effects. The process consists in subjecting dry ground seeds of Trigonella foenum graecum to a four-stage extraction procedure, where each stage comprises three steps and where four different solvents are used, as follows: a first extraction with acetone, a second extraction of the remaining material performed with 80...96% ethyl alcohol, a third extraction with a 40...70% hydro-alcoholic solution and, finally, a fourth extraction with purified water heated to 30...60°C, the spent residual material being afterwards recycled as compost. The phytotherapeutic extracts obtained from each stage are processed and purified to result in fenugreek oil, standardized extract with steroidal saponins and flavonoids or only steroidal saponins, diosgenine and bioactive polysaccharide complex. The phytotherapeutic preparations are conditioned in various dermato-cosmetic forms to be employed in the therapy of aged cutaneous tissue or in the therapy of acne formations.
Patent RO-133154-A0 (RO)
Title: Plane-parallel guiding device and method
Inventor: NEAGOE MIRCEA
IPC: B23B49/02
Filed: 2018-09-19
Abstract: The invention relates to a device and a method of plane-parallel linear and angular guiding of a mobile frame with plane-parallel movement related to a fixed frame, meant to align technological equipments or devices mounted on the mobile frame, with the blanks which systematically get in the processing area with plane guiding errors. According to the invention, the device consists of five screw mechanisms (A, B, C, D and E), parallelly mounted between a frame (0) and another frame (1), the linear guiding mechanisms (A and B) being orthogonally placed and consisting of a screw (2), a fixed nut (3), a pressure disk (5) and an element (6) profiled at the exterior following a circular arc with a radius (R), the mechanism (C) for blocking the translation of the frame (1) consisting of a screw (8), a fixed nut (9), a cup (11) inside of which a cup (13) may axially move under the action of a compression coiled spring (14), a pressure element (15) and an element (16) profiled at the exterior following a circular arc having a radius (R), and the angular guiding mechanisms (D and E) comprising a screw (17), a fixed nut (18) and a spherically profiled pressure element (20) being in contact with a plane bracket (21). The claimed plane-parallel guiding method associated to the plane-parallel guiding device consists of four stages, namely, in a first stage the movement of the frame (1) in relation to the other frame (0) is unblocked, while linearly guiding the frame (1), followed by the angular guiding of the frame (1) and, in the end, the blocking of the frame (1) in relation to the other frame (0).
Patent AP-2001002036-A0 (AP)
Title: Use of glucose uptake enhancer for reducing apoptosis.
Inventor: BRIL ANTOINE MICHEL ALAIN
IPC: A61P/
Filed: 1999-07-21
Abstract: A method for reducing or preventing apoptosis of differentiated cells selected from the list consisting of cardia myocytes, pancreatic beta cells, endothelial cells and neuronal cells in the human or non-human mammal, which method comprises administration, including acute administration, of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-mammal in need thereof.
Patent LU-74694-A1 (LU)
IPC: A61K31/22
Filed: 1976-04-02
Abstract: The present disclosure relates to steroid carboxylic acids and derivatives thereof. More particularly, the disclosure is concerned with D-homosteroid carboxylic acids and their derivatives, a process for the preparation thereof and pharmaceutical compositions containing same. The instant compounds are active endocrinal agents, especially as antiinflammatory agents.
Patent LU-81821-A1 (LU)
Inventor: PAUTY B
IPC: A47J36/38
Filed: 1979-10-25
Abstract: 1. A culinary utensil comprising a recipient (3, 18, 30) and a lid (1, 13, 17) intended for assuming an inclined position upon being opened, said lid including around its circumference (2, 22) an annular groove (7, 14, 24, 33) opening into said lid and capable, when this lid is opened, of collecting the steam condensates formed inside the utensil, characterized in that it comprises therein at least in a zone adjacent to the lowest point of the lid, an absorbing body (8, 34) capable of absorbing the condensates (12) accumulated in the aforesaid groove, means being provided to bring said condensates into contact with said absorbing body, when the lid is opened or closed.
Patent MA-26719-A1 (MA)
Title: PROCEDE POUR LA PREPARATION DE PYRAZOLO [4,3- d] PYRIMIDINE-7-ONES, ET INTERMEDIAIRES POUR CE PROCEDE
Inventor: PETER JAMES DUNN
IPC: C07D239/22
Filed: 2000-02-16
Abstract: L'INVENTION CONCERNE UN PROCÉDÉ POUR LA PRÉPARATION D'UN COMPOSÉ DE FORMULE (IA) ET D'UN COMPOSÉ DE FORMULE (IB) ELLE CONCERNE ÉGALEMENT LES INTERMÉDIAIRES UTILISÉS POUR CETTE PRÉPARATION.APPLICATION : UTILISATION DE CES COMPOSÉS DANS LA PRÉPARATION DES MEDICAMENTS POUR LE TRAITEMENT DE DIVERSES MALADIES, NOTAMMENT D'UN DYSFONCTIONNEMENT DE L'ÉRECTION MASCULINE.
Patent MA-25160-A1 (MA)
Title: Machine produisant l'eau claire.
Inventor: FAIK MUSTAPHA
Filed: 2000-08-09
Abstract: LA MACHINE PRODUISANT L'EAU CLAIRE TRANSFORME L'EAU POLLUÉE EN EAU CLAIRE D'UNE FAÇON CONTINUE SANS RUPTURE.  LA MACHINE PRODUISANT L'EAU CLAIRE REÇOIT L'EAU POLLUÉE ET DONNE EN SÉPARATION, TROIS ÉLÉMENTS :  1- L'EAU CLAIRE,  2- LES PRODUITS DE POLLUTION MOINS DENSES QUE L'EAU,  EN CONCENTRATION.  3- LES PRODUITS DE POLLUTION MOINS DENSES QUE L'EAU,  EN CONCENTRATION.  TOUTES LES PARTICULES EN SUSPENSION DANS L'EAU SONT ÉLIMINÉES ET L'EAU RESTE CLAIRE.  -LA MACHINE PRODUISANT L'EAU CLAIRE TRANSFORME AUSSI PLUSIEURS LIQUIDES POLLUÉS EN LIQUIDE CLAIR.  LA MACHINE PROUISANT L'EAU CLAIRE  EST ALIMENTÉE PAR LA TENSION ÉLECTRIQUE 220 V  ALTERNATIF.  SA PUISSANCE DE CONSOMMATION EST MOINS DE 1 KW HEURE PAR 10 TONNE  D'EAU CLAIRE,  SON DÉBIT DÉPEND DU CYLINDRE DE SÉLECTION,  SI PAR EXEMPLE LE VOLUME DU CYLINDRE DE SÉLECTION EST 1 MèTRE CUBE ALORS LE DÉBIT SERA AU MOINS 2  MèTRES CUBE PAR MINUTE.  CE DÉBIT PEUT eTRE AUGMENTÉ SUIVANT LE TYPE DE LA MACHINE ET LA QUANTITÉD'EAU POLLUÉE,  AUSSI LA CONSOMMATIONB PEUT eTRE DIMINUÉE SUIVANT LA QUALITÉE D'EAU POLLUÉE ET LE TYPE DE LA MACHINE.
Patent MA-26875-A1 (MA)
Title: Composes azapolycycliques a noyau aryle condensé
Inventor: JOTHAM WADSWORTH COE
IPC: C07D401/04
Filed: 2002-08-13
Abstract: DEPOSANT Société dite : PFIZER PRODUCTS INC, REVENDICATION DE PRIORITES US 25 Février 2000 09/514,002 Voir en annexe le titre de l'invention et le texte de l'abrégé Composés azapolycycliques à noyau aryle condensé L'invention concerne des composés de formule I et leurs sels pharmaceutiquement acceptables, formule dans laquelle R1, R2 et R3 répondent aux définitions figurant dans le présent mémoire ; des intermédiaires pour la synthèse de ces composés, des compositions pharmaceutiques contenant ces composés ; et des méthodes d'utilisation de ces composés dans le traitement de troubles neurologiques et psychologiques.
Patent MA-27015-A1 (MA)
Title: Amino-acides condenses bicycliques ou tricycliques
Inventor: BLAKEMORE DAVID CLIVE
IPC: C07C45/68
Filed: 2003-10-16
Abstract: DEPOSANT Société dite : WARNER-LAMBERT COMPANY LLC REVENDICATION DE PRIORITES GB	19 Avril 2001	0109635.3 GB	26 Octobre 2001	0125807.8 Voir en annexe le titre de l'invention et le texte de l'abrégé Amino-acides condensés bicycliques ou tricycliques Les composés de la présente invention sont des amino-acides bicycliques ou tricycliques utiles dans le traitement de l'épilepsie, d'attaques de faiblesse, de 1'hypokinésie, de troubles cr??niens, de troubles neuro-dégénératifs, de la dépression, de l'anxiété, de la panique, de la douleur, de l'arthrite, de troubles neuro??pathologiques, de troubles du sommeil, de troubles douloureux viscéraux et de troubles gastro-intestinaux. Des procédés pour la préparation des produits finals et des intermédiaires utiles dans ce procédé sont inclus. Des compositions pharmaceutiques contenant un ou plusieurs des composés sont également incluses.
Patent MA-27726-A1 (MA)
Title: Derives de 4-(4-(heterocyclylalkoxy)phenyl-1-(heterocyclyl-carbonyl) piperidine et composes associes servant d'antagonistes d'histamine h3 destines au traitement de troubles neurologiques
Inventor: MARK JAMES BAMFORD
IPC: C07D405/06
Filed: 2005-10-11
Abstract: "Dérivés de 4-(4-(hétérocyclylalkoxy}phényl)-1-(hétérocyclyl-carbonyl)pipéridine et composés apparentés servant d'antagonistes des récepteurs d'histamine H3 pour le traitement de maladies neurologiques telles que la maladie d'Alzheimer" La présente invention propose, dans un premier aspect, un composé de formule (I) ou un de ses sels pharmaceutiquement acceptables, formule dans laquelle : R1 représente un groupe -(alkyle en C1 à C6) -O- (alkyle en C1 à C6), -cycloalkyle en C3 à C8/ aryle, hétérocyclyle, hétéroaryle, ou d'autres groupes ; X représente une liaison, un atome de O, un groupe CO, OCH2, CH2O ou SO2 ; Z représente un groupe CO, CONR10 ou SO2 ; R10, représente un atome d'hydrogène, un groupe alkyle en C1 à C6, -cycloalkyle en C3 à C8, aryle, hétérocyclyle ou hétéroaryle ; A représente une liaison simple ou une double liaison, m et n sont égaux indépendamment à 0, 1 ou 2 ; R2 représente un atome d'hydrogène, un groupe alkyle en C1 à C6, ou alkoxy en C1 à C6 ; R3 représente un atome d'halogène, un groupe alkyle en C1 à C6, hydroxy, alkoxy en C1 à C6, cyano, amino, -CO(alkyle en C1 à C6) , -SO2(alkyle en C1 à C6) ou trifluorométhyle ; R4 représente un groupe (CH2)9-NR11R12 ou un groupe de formule (i) dans lequel tous les autres substituants sont tels que définis dans la revendication 1. Des composés de formule (I) et leurs sels pharmaceutiquement acceptables présentent une affinité pour le, et sont des antagonistes et/ou agonistes inverses du, récepteur d'histamine H3 et il est considéré qu'ils sont potentiellement utiles dans le traitement de maladies neurologiques, y compris la maladie dalzheimer.
Patent MA-37593-A1 (MA)
Title: Horodateur de parking a gestion et paiement mobiles
Inventor: ABDELLATIF BENABDELLAH
IPC: G07B15/02
Filed: 2014-11-28
Abstract: Un système horodateur de parking avec paiement et gestion par mobile. Il utilise des moyens technologiques basiques disponibles dans tous les pays et offre des moyens de contrôle et de facturation. Il permet à tout propriétaire de téléphone mobile simple ou intelligent avec un abonnement gsm à réserver et régler sa place de parking en utilisant uniquement les services de messagerie sms. Le contrôle utilise également la messagerie courte sms. Une application serveur gère les communications sms, les réservations, les paiements, le contrôle et la facturation.
Patent MA-51971-A1 (MA)
Title: Stéroïdes et leurs conjugués protéiques
Inventor: OLSON WILLIAM
IPC: C07J71/00
Filed: 2017-11-07
Abstract: L'invention concerne des conjugués de stéroïdes protéiques qui sont utiles, par exemple, pour l'administration spécifique à une cible de glucocorticoïdes (gc) à des cellules.
Patent UY-23361-A1 (UY)
Title: Unidad de mantenimiento del telefono publico modular
Inventor: ARANGONCILLO BALLESTERO ANTONIO
IPC: H04M1/24
Filed: 1992-01-23
Abstract: La unidad se constituye a partir de un microprocesador, un bloque de comunicación con el teléfono modular, un conmutador rotativo de toma de medidas, y un cargador de condensadores del teléfono público modular, disponiendo de un cargador rápido de condensadores de alimentación del teléfono modular que realizara la carga de la lógica y de los actuadotes, permitiendo a la unidad la comunicación por cualquier teléfono situado en una línea protegida con una unidad de validación e identificación, realizándose la misma mediante selección del numero identificativo en conmutadores giratorios. Igualmente la unidad dispone de bloques de circuito para la medida de tensiones en condensadores de alimentación, corriente de línea, tensiones alternas respecto a tierra y estado de batería.
Patent UY-29108-A1 (UY)
Title: Ligandos de difenil éter terapéuticos
Inventor: CLAFEY MICHELLE MARIE
IPC: A61K31/33
Filed: 2005-09-08
Abstract: Esta invención se refiere a compuestos de fórmula Ia,Ib o Ic y a las composiciones farmacéuticas de los mismos o un profármaco de los mismos y un vehículo farmacéuticamente aceptable, en los que los grupos R se han definido en la memoria descriptiva; y en los que la línea de puntos representa un doble enlace opcional. Procedimiento de tratamiento, de diagnóstico, y de prevención de trastornos del sistema nervioso central que están asociados a los receptores de 5HT.
Patent ES-160739-A1 (ES)
Title: PROCEDIMIENTO PARA LA SULFIDACIoN CONTINUA DE CELULOSA ALCALINA
Filed: 1943-03-18
Abstract: Procedimiento para la sulfidación contínua de celulosa alcalina caracterizado porque en materia y álcali deseado para la viscosa ulterior es añadido correspondientemente dosificado sulfuro de carbono en la cantida calculada en el contenido final en azufre combinado sometiendo la masa hasta terminación de la reacción a un tratamiento de efecto cortante.
Patent ES-172146-A1 (ES)
Title: PERFECCIONAMIENTOS EN LA FABRICACIoN DE ELEMENTOS DE EDIFICACIoN
Filed: 1946-01-14
Abstract: Perfeccionamientos en la fabricación de elementos de edificación caracterizados por un elementos de mortero que comprende caras en sus lados opuestos separados entre sí por un núcleo celular que tiene las paredes de las células integralmente unidas con las caras.
Patent ES-175463-A1 (ES)
Title: CABALLETE PARA MáQUINAS DE HILAR Y DE PREPARACIoN
IPC: D01H5/74
Filed: 1946-10-08
Abstract: Caballete para máquinas de hilar y de preparación constituido por un elemento de base dispuesto para ser montado sobre una parte fija de la máquina y una pieza o elemento superior de soporte de los rodillos la cual está montada sobre dicho elemento de base de manera que se pueda regular su posición aproximándola o apartándola en su conjunto de dicho elemento de base o bien haciéndola oscilar alrededor de cualquiera de sus dos extremos a fin de poder regular a voluntad la altura o la inclinación del plano determinado por los rodillos montados en dicha pieza o elemento de soporte.
Patent ES-181741-A1 (ES)
Title: Procedimiento para la obtencion de un revestimiento aislante termico y fonico, a base de celulosa
Filed: 1948-01-17
Abstract: Procedimiento para la obtención de un revestimiento aislante térmico y fónico, a base de celulosa, caracterizado por la preparación de una mezcla de magnesia calcinada con cloruro de magnesia, cuyos elementos forman el aglutinante del conjunto o mezcla total, preveyéndose la utilización de ambos como tal aglutinante y también como componentes característicos de la mezcla, completándose con una parte del producto procedente de la aglomeración de la celulosa en pajitas y una parte de agua. Se adicionarán pigmentos para la obtención del colorido deseado.
Patent ES-190306-A1 (ES)
Title: PROCEDIMIENTO PARA LA FABRICACIoN DE DERIVADOS DE QUINOLINA
Filed: 1949-11-05
Abstract: Procedimiento para la fabricación de derivados de quinolina caracterizándose por obtenerse especialmente sales bicuaternarias de pirimidilaminoquilolinas de la fórmula PqNHQq en la que P representa un núcleo pirimidínico 2-amino- o 2-alcohilamino inferior sustituido unido al grupo de enlace -NH- en la posición 4 y que puede estar además sustituido en la posición 6 por un grupo alcohilo inferior Q representa un núcleo quinolínico sustituido en la posición 4 por un grupo amino o alcohilamino inferior y que puede estar además sustituido por un grupo alcohilo inferior o varios y que contiene el grupo d enlace -NH- en la posición 6 y los símbolos o indican que los núcleos anteriores P y Q respectivamente están presentes en la forma de sus sales cuaternarias que comprende el someter a la acción de amoniaco o de una alcohilamina inferior un compuesto de la fórmula en la que los símbolos qq indican que el compuesto es una sal bicuaternaria que contiene un grupo cuaternario en el núcleo quinolínico y el otro en el núcleo pirimidínico y X e Y representan grupos amino o alcohilamino inferiores o los grupos -SR o -OR en los que R representa un radical hidrocarburado a condición de que de X e Y uno por lo menos sea -SR o -OR y A representa hidrógeno o un grupo alcohílico inferior y B representa hidrógeno o un grupo alcohílico inferior.
Patent ES-330374-A1 (ES)
Title: Ion source with spaced electrode ionizing pits
IPC: H01J27/02
Filed: 1966-10-27
Abstract: An ion source with axial or planar symmetry comprises an electron emitting cathode 6 and a pipe 7 for introducing gas, an electrode 5 with an ion extraction aperture 8, and a plurality of alternately positive and negative electrodes 9, 10 immersed in an axial magnetic field. The discharge mechanism is such that electrons and ions oscillate in the potential wells of the positive and negative electrodes respectively and a dense plasma is formed. The chamber wall 2 has a cooling circuit 3. In another embodiment with a cylindrical chamber, Fig. 2 (not shown), the negative electrodes partition the chamber into successive chambers between which there is a pressure gradient. A suitable gas is hydrogen with the pressure varying from 10-1 Pascal to 2À10-2 Pascal. In an embodiment with the chamber in the form of a flat box, Fig. 3 (not shown), the negative electrodes are constituted by pairs of flat plates and the positive electrodes by rectangular plates with rectangular apertures. A number of cathodes are provided in the end wall of the chamber. A further embodiment, Fig. 4 (not shown), comprises an annular chamber of rectangular cross-section. In all embodiments the magnetic field may be uniform or of varying intensity with e.g. a magnetic mirror field in the region of the cathode. Coils or permanent magnets may be used.
Patent ES-336864-A1 (ES)
Title: Apparatus and method for making a slurry
IPC: B02C17/06
Filed: 1967-02-15
Abstract: A tube mill has at least two compartments 5, 16 separated by an internally hollow ring 8 presenting a sieve face to each compartment, so that ground material may pass from each compartment into the hollow ring for discharge from the mill. As described, the ring 8 has central hole 11 and rims 26 joined by radial bars 9, Fig. 2 (not shown), with the spaces spanned by sieve plates. Outlet openings 13 are made in the mill shell around the area closed by the ring 8, and this part of the mill is surrounded by a casing 14 having a slurry outlet 15. There are provided lifters 7 in the internal wall of the mill, lifters 17 on the side of the ring facing the inlet and lifters 22 on the end face 21. In operation, water is introduced via a pipe 4 and additional water through a trunnion 19 by a pipe 27. Solid materials are washed and partially ground in the first compartment to form a slurry, adequately fine material passing through the sieves 10 into the outlet channel constituted by the interior 12 of the ring, and thence to the outlet 15. Coarser material passes through the ring into the compartment 16 and is autogeneously ground and freed of all washable particles. The fluidity of the slurry is increased by additional water supplied by the pipe 27 and passes out of the compartment via the sieves in the ring 8. The material resistant to grinding passes from the mill by an outlet trunnion 19. Where the mill is provided with several compartments, more than one hollow ring may be used to provide adequate outlet for the slurry.
Patent ES-337834-A1 (ES)
Title: One component diazotype material
IPC: G03C1/54
Filed: 1967-03-10
Abstract: The invention comprises compounds of the formula <FORM:1110835/C2/1> where R1 and R2 are aralkyl groups which may be halogen substituted, X is Cl or Br, Y is an acid anion and Z is -CH2OH, -CH2CH2OH, -CH(OH)-CH3 or -CH(OH)-CH2OH, and double salts thereof with a metal salt. An example describes the preparation of N,N-dibenzylamino - 2(2 - hydroxyethoxy) - 5 - chloro-4-diazo benzene in the form of its stannic chloride double salt by reacting 4-chloro-2-nitro phenol with acetic acid to give 4-chloro-2-nitro phenol acetate, reducing this with iron powder and HCl to 4-chloro-2-acetyl-amino phenol, reacting this with 2-chloro ethanol to give 4-chloro-2-nitro (2-hydroxyethyl) phenol, removing the acetyl group with H2SO4, dibenzylating with benzyl chloride, nitrating with concentrated HNO3, reducing the nitro group to the amine and diazotizing. The other compounds of the general formula given above may be similarly prepared.