baber/WOPTO huggingface dataset:
Patent AU-2013203748-C1 (AU)
Title: Antigen Binding Proteins to Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)
Inventor: SHAN BEI
IPC: A61P3/06
Filed: 2013-04-11
Granted: 2017-05-25
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an 5 antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. WO 2009/026558 PCT/US2008/074097 1-----------------------------------------------50 PCSK9parent (1) OZUNUGOYEiMIIAj '5EdGLAAP$1k5G5A~'iFRIKdPWESPG3YVV PCSK9mutants (1) R _1iRRRR RR FiliRdl lPWfi PdlYVV 51--- pro domain ------------------------------ 100 PCSK9parent (51) VNIIiIT LN NiTKII~if9FINGLLPGFLVf§fd PCSK9mutants (51) V-'Lj lKS! S TgF LKlIAil E-li TKIIAlFiGLLPGFLMEliF L 101-------------------=======50 PCSK9parent (101) ILELAILf LMNiUdYIEEDSSVFISIFINIlEItIPPRYRAf0EidPidGGI4V PCSK9mutants (101) EIL L YEI 1 IlPPRYR lIPIGGV 151================================ -------=== 200 PCSK9parent (151) E EAS CDSI-GTHL PCSK9mutants (151) EVYLLD'II|RRRH|EEEIDGRVRRRERRRERRRRRRERRR CDRqGTHL 201===---=============---=----------= = -====250 PCSK9parent (201) AGVVSG fAGVAINgfMRSI NVLNdGNGtVSGTLIGLEINI!NZ5~QvdB~9 PCSK9mutants (201) AGVVSGFPAGVA lidNlMRSlVLNClG1GlVSGTLIGLElR S P 251================= catalytic domain =========300 PCSK9parent (251) 7PLVVLLPLAGYSIVLtACQ RLIN GVVLVTAAGNF1 DDAC YSPA2A PCSK9mutants (251) 'PLVVLLPLAdlYSEVL lAdARLAEGVVLVTAAGNEEDDACRYSPARA 301============================================------350 PCSK9parent (301) PEVITVGATNQDQP TIGTI4GTNFGRCVDLFAPGEdIIGAS8CSC5' PCSK9mut ants (301) PEVI TVGA TNIRNRP(PMiiliGPGTNFGRCVDLFAPGl 9I I GAS$1 CSI Cli 351-= = = = = = = = = = == = = = = = = = = = = 400 PCSK9parent (351) 5 GSAAVGAIMjA5ILiAIL~ SK9IEEF PCSK9mutants (351) |PSGTAHAI I 401===------------------------------------------450 PCSK9parent (401) INININTPI LVA LPP5TN SG LFCRTVWSS WSRIbAl CAB PCSK9mutants (401) '__RRTALVALPPRRRRRRLFCRTWIS RRRECB 451--------------------------------------------500 PCSK9parent (451) EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGP2GVYAIARCCLLP PCSK9mutants (451) EELLSCSSFSRSGKRRGERMERQGGKLVCRAHNR9GRCGVYAIARCCLLP 501-------------- v domain ------------------------ 550 PCSK9parent (501) QANCSVHdAPPZEAIN GTI-iViSfdQHQ GHVLTGCSSHVEfldG'IKPPIMLR PCSK9mutants (501) QACSViiAPPA lIiGII Cl liGHVLTGCSSHailIlGi KPFliLR 551---------------------------------------------------600 PCSK9parent (551) PINGdNQCVGHREASIHASCCHAPGLECkVKEIIPAVQEidVTPfCIZGW PCSK9mutants (551) PFIPlQCVGHREASIHASCCHAPGLEC(RRR IPAi ElVT\lCfGW 601--------------------------------------------650 PCSK9parent (601) TLTGCSALPGTSHVLGAYAIMDNTCVVR$NDVSTTGSTSEIEAVTAVAICCN PCSK9mutants (601) TLTGCSALPGTSHVLGAYAliDNTCVVRD ER _ V A 651 --------- 680 PCSK9parent (651) SPHLAQASQELQGSSDYKDDDKHHHHHHHH (SEQ ID NO:303) PCSK9mutants (651) S&HLAQASQELQGSSDYKDDDKHHHHHHHH (SEQ ID NO:304)
Patent AU-2013296627-C1 (AU)
Title: Deuterated ibrutinib
Inventor: TUNG ROGER D
IPC: C07B59/00
Filed: 2013-07-30
Granted: 2016-12-15
Abstract: The present invention in one embodiment provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula (I) are as defined in the specification.
Patent AU-2014300703-C1 (AU)
Title: Improved inventory sourcing system
Inventor: VAN VAERENBERGH BRUNO
IPC: G06F7/00
Filed: 2014-06-27
Granted: 2020-05-21
Abstract: Aspects of the invention relate to a computer-implemented method of improving the efficiency of an electronic collateralisation search engine that uses assets distributed on one or more remotely-located asset depositories. The method comprises selecting from a database of asset records of the remotely-located assets of a collateral giver, a subset of asset records having asset characteristics that satisfy a collateral giver's one or more predefined threshold criteria. Restricting a received search of collateral giver's asset records, which match a collateral receiver's query, to the subset of collateral giver's asset records.
Patent AU-2015278235-C1 (AU)
Title: A rail crossover control system
Inventor: DA COSTA ILIDIO GOUVEIA
IPC: B61L19/00
Filed: 2015-06-16
Granted: 2022-11-17
Abstract: A rail crossover control system for a rail track section is disclosed. The rail track section has first and second rail tracks, a crossover track section extending between the first and second rail tracks, at least one first set of rail switches arranged to controllably determine whether a train continues on the first track or is diverted from the first track onto the crossover track section, and at least one second set of rail switches arranged to controllably determine whether a train continues on the second track or is diverted from the second track onto the crossover track section. The system comprises at least one interlocking control unit arranged to control the first and second sets of rail switches according to determined train routes, and an obstruction detector arranged to detect presence of an obstruction on the crossover track section and generate an obstruction signal when an obstruction is detected.
Patent AU-2017260678-C1 (AU)
Title: Sealing device for a sliding door
Inventor: DINTHEER ANDREAS
IPC: E06B7/215
Filed: 2017-05-04
Granted: 2020-02-20
Abstract: A sealing device of a sliding door with a displaceably mounted door leaf has a lowering seal with a sealing strip (11, 12) and with an actuating mechanism for automatically lowering and raising the sealing strip (11, 12). The sealing device has an activating unit (2, 3, 4) for activating the lowering seal, wherein the activating unit has a first contact surface (21, 22), a pivotably designed contact element (3) and a pivotably designed force transmission element (4). Upon closing of the door leaf, the contact element (3) contacts the first contact surface (21, 22) and moves, during the closing movement of the door leaf, with pivoting of the contact element (3), along the first contact surface (21, 22). A pivoting movement of the contact element (3) results in a pivoting movement of the force transmission element (4), with the result that the latter actuates the lowering seal.
Patent RU-2168371-C1 (RU)
Inventor: ATABAEV A B
IPC: B04B1/04
Filed: 2000-03-21
Granted: 2001-06-10
Abstract: FIELD: equipment for separating finely dispersed liquid in different branches of industry. SUBSTANCE: supercentrifuge includes tubular rotor with upper and lower covers. Unit for feeding initial suspension is arranged in lower part of rotor. Unit for discharging clarified liquid is arranged in upper portion of rotor. Rotor is mounted on metallic shaft. Spherical covers are secured to upper and lower portions of shaft. Rotor wall is made of thin high-strength steel; winding of polymeric material is arranged on its outer surface. Said winding may be of glass fibers reinforced by epoxy resin. It is rationally to place in rotor separation insert formed by means of solid belt bent along helix and made of polymeric material having porosity with predetermined size and shape of pores or combination type polymeric material. Winding also may be made of reinforced polymeric belt. Design of supercentrifuge provides its rotation with increased revolution number due to improved strength of rotor. EFFECT: enhanced operational reliability of supercentrifuge. 4 cl, 3 dwg
Patent RU-2183708-C1 (RU)
Title: Metal building frame
Inventor: BIRIN V A
IPC: E04B1/38
Filed: 2000-12-05
Granted: 2002-06-20
Abstract: FIELD: civil engineering, in particular, metal frames of multispan buildings. SUBSTANCE: the metal frame of a multispan building has I-shaped columns, having bearing members at the level of the floors, they are positioned on the outer side of the flanges of the I-shaped columns. The beams are built up of two metal members of channel bar or I-shaped section, which by the upper flanges are hanged and rest against the column bearing members. The beams are made continuous and may have an inner reinforced- concrete member located in the cavity between the metal members. EFFECT: reduced acting loads and thus reduced specific consumption of materials. 4 cl, 4 dwg
Patent RU-2189896-C1 (RU)
Inventor: TILIPALOV V N
IPC: B24B9/16
Filed: 2001-01-03
Granted: 2002-09-27
Abstract: FIELD: treatment of semiprecious-stone products of composite profile. SUBSTANCE: device has fixed stop, driving abrasive wheel, and platform mounting blank holder coupled with template. The latter functions to set holder in composite motion within definite section of path. Additional holders carry additional composite templates of different shapes for continuous planetary movement about common axis and periodic engagement with fixed stop. Abrasive wheel peripheral profile corresponds to profile of cabochon top. Platform is mounted for displacement in plane perpendicular to butt end of abrasive wheel. EFFECT: enhanced productivity, enlarged functional capabilities of device. 3 dwg
Patent RU-2190957-C1 (RU)
Title: Method for diagnosing psychical condition
Inventor: ZAJTSEV O S
IPC: A61B5/16
Filed: 2001-03-22
Granted: 2002-10-20
Abstract: FIELD: medicine. SUBSTANCE: method involves investigating time perception patterns on signals shown. The signals are shown in single increasing sequence from 2 to 60 s. First, interval assessment tests are carried out and then their reproduction is tested. Error rate being greater than 20% when compared to control values, psychic condition disorders risk is to be diagnosed. The errors being detected in increasing intervals beginning from 10 s, intellectual psychic condition disorders are considered to be diagnosed. EFFECT: high accuracy of diagnosis.
Patent RU-2199731-C1 (RU)
Title: Устройство для определения влажности нефтепродуктов в трубопроводе
Inventor: AKHOBADZE G N
IPC: G01N22/04
Filed: 2001-06-08
Granted: 2003-02-27
Abstract: Изобретение относится к измерительной технике и может быть использовано в системах управления технологическими процессами. Техническим результатом является повышение точности измерения. Устройство содержит первый микроволновый генератор, подключенный к циркулятору, первый элемент связи, расположенный на наружной поверхности круглого волнового резонатора, первый детектор, измеритель амлитудно-частотных характеристик, второй микроволновый генератор, подключенный ко второму элементу связи, расположенному на наружной поверхности диэлектрической трубы, третий элемент связи, второй детектор, подключенный к делителю, блок индикации. 4 ил.
Patent RU-2191245-C1 (RU)
Inventor: BUTKIN V D
IPC: E21B10/22
Filed: 2001-07-17
Granted: 2002-10-20
Abstract: FIELD: drilling equipment, particularly, designs of roller cutters for drilling of blast holes in ore mining industry and drilling of processing wells for oil and gas. SUBSTANCE: roller-cutter drilling bit has section with axle installed in drilling bit body and roller cutter lockind on axle, floating bushing, conjugated conical surfaces, thrust bearing, flexible sealing members and spacers installed in axle circular groove, and roller cutters with fastening members. Section has shank carrying axle with roller cutter. Said shank is made in the form of truncated cone installed in bit body hole and secured with interference fit by means of bolt screwed vertically through hole in body upper part into end of shank eccentrically relative to shank longitudinal axis and additionally by means of lock in the form of rod with conical end screwed into body horizontal hole and entering conical hollow made on shank side surface. Lock joint of roller cutter and axle is made in the form of unsplit captived flange with two levels of working surface whose upper central part is made with contact on thust projection of axle on inserted shank whose periphery part is rigidly secured by fastening members in bore at edge of roller cutter edn, and flange lower part has cylindrical projection entering circular groove between axle and roller cutter body for pressing and holding of flexible sealing members in said groove. Unsplit captive flange is covered by means of washer with low friction coefficienct. Axle has oil channel-receiver drilled in side surface of inserted shank along axis of roller cutter rotation. Installed in channel-receiver with circular gap is flexible rod with splined surface with flexible rod lower end secured in bottom of roller-cutter body, and its upper end freely enters cylindrical socker of threade plug. EFFECT: higher operating reliability and prolonged service life. 3 cl, 3 dwg
Patent RU-2190104-C1 (RU)
Inventor: ELISEEV JU S
IPC: F25B30/00
Filed: 2001-08-24
Granted: 2002-09-27
Abstract: Изобретение относится к теплоэнергетике, в частности к энергетическим установкам. Энергетическая установка, содержащая снабженную выходом на полезную нагрузку парогазовую установку с вводом пара, выход которой подключен к первому входу подогревателя, первый выход которого подключен к первому входу конденсатора, первый выход которого сообщен с окружающей средой, первый контур циркуляции воды, подключенный ко второму входу и второму выходу конденсатора, включающий последовательно соединенные первый насос и холодильник, по его первому входу и первому выходу, а также второй контур циркуляции воды, подключенный ко входу ввода пара парогазовой установки и к первому контуру циркуляции воды, включающий последовательно соединенные второй насос и подогреватель, по его второму входу и второму выходу. Установка дополнительно содержит теплообменник, компрессор и дроссель, вход которого связан с первым выходом теплообменника, а выход - со вторым входом холодильника, вход компрессора связан со вторым выходом холодильника, а выход - с первым входом теплообменника, образованный при этом замкнутый контур заполнен рабочим телом, а своими вторым входом и вторым выходом теплообменник последовательно включен во второй контур циркуляции воды. Одним из частных вариантов решения установки является включение первого насоса между первым выходом холодильника и вторым входом конденсатора. Другим частным решением установки является включение первого насоса между вторым выходом конденсатора и холодильником и подключение второго контура циркуляции воды к выходу первого насоса. Изобретение позволяет уменьшить потери тепла и воды в окружающую среду. 2 з.п. ф-лы, 1 ил.
Patent RU-2203146-C1 (RU)
Title: Centrifuge for separation of fillmass sugar of sugar production process
Inventor: LILA N G
IPC: B04B11/02
Filed: 2001-11-21
Granted: 2003-04-27
Abstract: FIELD: equipment for separation of non-homogeneous systems under action of centrifugal forces; sugar industry. SUBSTANCE: centrifuge has casing, filtering drum mounted on drive shaft, segregator made in form of ring manufactured from elastic material for change of its external diameter and circular partition mounted on bottom of casing forming concentric passages for separate discharge of runoff syrup. Segregator ring is hollow and is provided with branch pipe fitted with valves for supply and discharge of air. Concentric passages are provided with steam supply unit. Centrifuge shall be used for centrifuging fillmass sugar of first product, intermediate products, as well as for sugar affination of brown sugar of last crystallization cycle in processing sugar beets and raw sugar. EFFECT: enhanced operational reliability of segregator due to complete closing of peripheral passage discharging runoff syrup. 2 dwg
Patent RU-2211995-C1 (RU)
Inventor: ARTEMOV V N
IPC: F16L59/00
Filed: 2001-11-26
Granted: 2003-09-10
Abstract: FIELD: application of heat insulation; manufacture of hermetic pressure vessels; chemical and food-processing industries; mechanical engineering; manufacture of reservoirs for beer and kvass during fermentation, final fermentation and maturing. SUBSTANCE: proposed method is used for application of heat insulation on apparatus having shells and spherical and conical bottoms; anticorrosive coat is applied on outer surface of shell after which thrust members are secured on outer surface of shell; thrust members are made in form of bars manufactured from heat-insulating material; bandages and waterproofing gasket are mounted on said bars and protective envelope is secured in place; then space between outer surface of apparatus and waterproofing gasket is filled with heat-insulating material; first, heat insulation is laid on conical bottom and is connected with shell, after which apparatus is positioned horizontally for turn around longitudinal axis; then, thrust members are mounted over end faces of shell; remaining members are shifted from center of coupling bandage through distance equal to 2-3 of widths of thrust member; ends of bandage band are connected by permanent joint after creation of mounting tension ensuring specific pressure on thrust members from 0.2 to 0.6 kgf/sq cm; protective envelope is secured on bandage by horizontal sections at height equal to width of protective envelope sheet; then apparatus is turned to position at which section of protective envelope takes lower position and coupling clips made from flexible material are mounted on outer surface of protective envelope in spaces between bandages till protective envelope sags inside space being filled by amount of subsequent sag in foaming of heat-insulating material and space between housing and waterproofing insulation is filled. EFFECT: low cost; increased productivity. 5 cl, 15 dwg
Patent RU-2193082-C1 (RU)
Inventor: CHEREPEN KO A A
IPC: A41H43/00
Filed: 2001-12-06
Granted: 2002-11-20
Abstract: FIELD: light industry. SUBSTANCE: method involves steaming through semi-finished article; pressing article in 3/4 of steaming-through time; subjecting article to mechanical loading for time interval equal to 1/4 of steaming-through time; stopping steaming-through procedure and holding under load while acting upon it with upper surface of pad heated to temperature not in the excess of 200 C for preliminarily drying; stopping drying procedure at the initial stage of unloading process. EFFECT: intensified drying and moisture removal processes and improved quality of wet-thermal treatment. 1 ex
Patent RU-2218263-C1 (RU)
Inventor: KOROLEV A V
IPC: B24B53/12
Filed: 2002-03-20
Granted: 2003-12-10
Abstract: FIELD: mechanical engineering; restoration of cutting ability of grinding disks at required geometric shape. SUBSTANCE: body is fixed on machine bench. Dressing tool is mounted by means of two or more flexible members having form of plates. To limit amplitude of dressing tool oscillations, rigid stop is mounted in body base. Such construction provides for performing oscillations in one direction only; availability of stop prevents damage of device. EFFECT: enhanced efficiency and reliability. 1 dwg
Patent RU-2211205-C1 (RU)
Title: Method of preparing modifying additives
Inventor: EFIMOV P A
IPC: C04B28/02
Filed: 2002-03-28
Granted: 2003-08-27
Abstract: FIELD: manufacture of building materials. SUBSTANCE: method of preparing complex modifying additives for cement formulations can find use in manufacture of dry building mixes, ready-to-use building mortars, etc., in particular when raising cast-in-place constructions, as well as pigmenting additives, which can be used in varnish-and-paint industry for building materials and manufacture of colored cements, ceramics, and others. Method comprises mixing mineral filler with additional active ingredient at their specified proportions (50-95% and 5- 50%, respectively) followed by active stirring in turbulent flows, which is achieved by two-step treatment in mixer within gaps between rotor and casing. Under such conditions, shock loading velocity rises from 0 to 50 m/s in the first step and from 50 to 100 m/s at the second step over 1-10 sec time interval at 40 C. As mineral filler, calcite, barite, limestone flour, marble flour, dolomite flour, dust-like quartz, various types of cement, gypsum, corundum, and amorphous silica can be used. Additional active ingredient can be represented by at least one ingredient from group comprising redispersed powders of vinyl acetate, acrylate, and butadiene/styrene copolymers and homopolymers, cellulose ethers, water- soluble plasticizing, water-reducing, air-entraining, waterproofing, and pigmenting additives in dry state. EFFECT: enhanced efficiency of production of multifunctional modifying additives. 3 cl, 2 tbl
Patent RU-2217226-C1 (RU)
Inventor: SYSUEV V A
IPC: B01F7/24
Filed: 2002-06-18
Granted: 2003-11-27
Abstract: FIELD: devices for mixing loose materials; agricultural equipment and combined fodder industry. SUBSTANCE: proposed mixer includes mixing chamber made in form of cylindrical bin with bottom made in form of truncated cone; working member - worm feeder is enclosed in pipe mounted along axis of chamber. Pipe is provided with truncated cone in its upper part; varying pitch of worm feeder winding increases towards upper part of mixing chamber. Mounted in base of worm feeder is proportioner equipped with diametric proportioning damper. Mixer is provided with loading branch pipe for loading main component. Finished product is unloaded through unloading branch pipe with damper open. Entrapping filter performs function of dust collector. EFFECT: reduced power requirements; improved quality of mixing. 3 cl, 2 dwg
Patent RU-2205393-C1 (RU)
Title: Cell for detection of gas phases for analysis
Inventor: KORENMAN JA I
IPC: G01N5/02
Filed: 2002-06-28
Granted: 2003-05-27
Abstract: FIELD: analytical chemistry. SUBSTANCE: invention is related to analytical chemistry of gas phases with use of piezoquartz method of micro weighing and can be employed for vapor-phase analysis and control over state of gas effluents of factories of food, chemical, pharmaceutical and perfume industries. Cell for detection of gas phases for analysis comprises body of cylindrical shape made of stainless steel, cover with holder of modified piezoquartz resonator, excitation circuit and branch pipes. Excitation circuit is directly joined to holder and is made fast on cover that has male thread for screwing into body. Base of body carries branch pipe with plug. Branch pipe for injection of sample has extension piece fitted with polyurethane gasket, it is so arranged in side of body that symmetry axis of branch pipe for injection of sample is perpendicular to symmetry axis of detection cell and passes through center coinciding with plane of modified piezoquartz resonator. EFFECT: change of functioning conditions of detection cell, simplified design of cell, use of branch pipe for injection of samples, possibility of fast blow-through of cell, reduced time of detection and analysis of gas phases, increased measurement accuracy. 2 dwg, 1 tbl
Patent RU-2217529-C1 (RU)
Title: Method of utilization of galvanic process sludge
Inventor: NAUMOV V I
IPC: C25D21/00
Filed: 2002-07-25
Granted: 2003-11-27
Abstract: FIELD: utilization of galvanic process sludge. SUBSTANCE: proposed method includes stages of leaching, regeneration, filtration and decontamination; prior to leaching, sludge is subjected to galvanic activation by water at high pressure, up to 15 Mpa; leaching of copper, nickel and zinc is performed in succession in one apparatus first with hydrochloric acid solution at concentration of 0.3-0.5 m/l and then in ammonia chloride solution of the composition, m/l: 0.3-0.5 NH 4 Cl + 3.0-4.0 NH 4 OH, which is formed at addition of excessive ammonia water into first solution. Proposed method ensures content of admixtures in separated metals. EFFECT: enhanced efficiency; waste-free process. 2 cl, 1 dwg
Patent RU-2213768-C1 (RU)
Inventor: BEKH N I
IPC: C10L1/32
Filed: 2002-08-29
Granted: 2003-10-10
Abstract: FIELD: alternate fuels. SUBSTANCE: method consists in mixing surfactant with water and heating resulting mixture to temperature not exceeding 90 C followed by stirring in apparatus using principle of electromagnetic swirl layer of ferromagnetic elements at magnetic field rotation frequency 1400-3000 rpm and field intensity 2-5 kW/cu.dm in working zone. Variants wherein surfactant is mixed with aliphatic alcohol and water as well as surfactant with aliphatic alcohol are envisaged. Method can be applied in fuel power engineering. EFFECT: increased water-fuel emulsion dispersity. 3 cl, 3 ex