Patent SG-11201809693S-A (SG)
Title: SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
Inventor: SKERLJ RENATO
IPC: C07D513/04
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0111010101111101011111 0 11101111101011111111001101111101111 Oil lil Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192930 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, CO7D 487/14 (2006.01) A61P 3/10 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7D 513/04 (2006.01) A61P 13/12 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 495/04 (2006.01) A61P 25/24 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 491/048 (2006.01) A61P 25/28 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 498/04 (2006.01) A61P 25/08 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 31/519 (2006.01) A61P 25/18 (2006.01) A61P 25/16 (2006.01) A61P 25/22 (2006.01) Published: A61P 27/06 (2006.01) A61P 43/00 (2006.01) — with international search report (Art. 21(3)) (21) International Application Number: PCT/US2017/031189 (22) International Filing Date: 05 May 2017 (05.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/332,151 05 May 2016 (05.05.2016) US (71) Applicant: LYSOSOMAL THERAPEUTICS INC. — [US/US]; 19 Blackstone Street, Cambridge, MA 02139 = (US). = (72) Inventors: SKERLJ, Renato, T.; 12 Crocker Circle, West — Newton, MA 02465 (US). BOURQUE, Elyse Marie Josee; = 162 Ch Bouffard, L'etang-du-Nord, Quebec, G4T 3G6 (CA). GREENLEE, William, J.; 115 Herrick Avenue, Teaneck, NJ 07666 (US). LANSBURY, Peter, T.; 24 Elm _ — Street, Brookline, MA 02445 (US). (74) Agent: DAVIS, Chad, E. et al.; Goodwin Procter LLP, 100 — Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = — PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = — SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, 1-1 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, © M (54) Title: SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COM- C:N POUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS ei cN (57) : The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine com- 1-1 ---- pounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and IN compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple sys- tem atrophy, in a patient. Exemplary substituted imidazo[1,2-b]pyridazine compounds described herein include substituted imida- f'1 zo[1,2-b]pyridazine-3-carboxamide compounds and variants thereof. 0