Patent SG-11201805150Q-A (SG)
Title: Variant antibodies for site-specific conjugation
Inventor: SHEPPARD PAUL O
IPC: A61K47/68
Filed: 2016-12-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011101110111110101011111111101111011111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... .....!;,,, 29 June 2017(29.06.2017) WIPO I PCT WO 2017/112624 Al (51) International Patent Classification: DO, C07K 16/00 (2006.01) A61K 47/68 (2017.01) HN, KP, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/US2016/067663 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, 20 December 2016 (20.12.2016) TH, ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, 62/270,245 21 December 2015 (21.12.2015) US TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY DK, [US/US]; Route 206 and Province Line Road, Princeton, LV, New Jersey 08543 (US). SM, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: SHEPPARD, Paul 0.; 13532 278th Drive NE, GW, KM, ML, MR, NE, SN, TD, TG). Granite Falls, Washington 98252 (US). ANDERSEN, Declarations under Rule 4.17: Henrik c/o Bristol-Myers Squibb Company, 38 Jackson as to applicant's entitlement to apply for and be granted a — Road, Devens, Massachusetts 01434 (US). SHAO, Xiang; patent (Rule 4.17(H)) c/o Bristol-Myers Squibb Company, 700 Bay Road, Red- wood City, California 94063 (US). RAO-NAIK, Chetana; — as to the applicant's entitlement to claim the priority of the c/o Bristol-Myers Squibb Company, 700 Bay Road, Red- earlier application (Rule 4.17(iii)) wood City, California 94063 (US). RAJPAL, Arvind; c/o of inventorship (Rule 4.17(iv)) Bristol-Myers Squibb Company, 700 Bay Road, Redwood = City, California 94063 (US). Published: Agents: CHAO, Yuan et al.; Bristol-Myers Squibb Com- — with (74) international search report (Art. 21(3)) = pany, Route 206 and Province Line Road, Princeton, New — before the expiration of the time limit for amending the Jersey 08543 (US). claims and to be republished in the event of receipt of Designated States (unless otherwise indicated, for every amendments (Rule 48.2(h)) = (81) kind of national protection available): AE, AG, AL, AM, — with AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, sequence listing part of description (Rule 5.2(a)) — = BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = = = = = = Il 7r N N Il Il IN Il 0 \" (54) Title: VARIANT ANTIBODIES FOR SITE-SPECIFIC CONJUGATION (:) ,.. (57) : Variant antibodies having cysteine substitutions at selected positions in the Fc region can be conjugated via the thiol group of the substituted-in cysteine.