Patent SG-11201907934Y-A (SG)
Title: Devices, methods, and compositions useful in cryo-preservation, -storage, -transport, and application of therapeutic mammalian cells
Inventor: SILVERMAN LARA
IPC: A61M5/31
Filed: 2018-03-02
Abstract: FIGDG' .• 1234567112345671123455711234567112345671123456711234 6711234567112345 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT omit VIII °nolo omioolionoin n110 oimIE (10) International Publication Number WO 2018/160991 Al 1-1 O 1-1 00 O C•11 C (51) International Patent Classification: AO1N 1/02 (2006.01) C12M 3/02 (2006.01) A61M 5/31 (2006.01) (21) International Application Number: PCT/US2018/020700 (22) International Filing Date: 02 March 2018 (02.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/466,228 02 March 2017 (02.03.2017) US (71) Applicant: DISCGENICS, INC. [US/US]; 675 ARA- PEEN DRIVE, SUITE 106, SALT LAKE CITY, Utah 84108 (US). (72) Inventors: SILVERMAN, Lara; 2568 EAST 3020 SOUTH, SALT LAKE CITY, Utah 84109 (US). DULA- TOV, Galina; 475 EAST TRITON CT., SALT LAKE CI- TY, Utah 84107 (US). TANDESKI, Terry; 8025 SOUTH CRANBERRY CIRCLE, SANDY, Utah 84093 (US). ERICKSON, Isaac; 3049 CORRAL DRIVE, LAYTON, Utah 84040 (US). (74) Agent: LEVITT, Kenneth E. et al.; 50 South Sixth Street, Suite 1500, Minneapolis, Minnesota 55402-1498 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (54) Title: DEVICES, METHODS, AND COMPOSITIONS USEFUL IN CRYO-PRESERVATION, -STORAGE, -TRANSPORT, AND APPLICATION OF THERAPEUTIC MAMMALIAN CELLS (57) : The disclosed compositions, methods, and devices are useful in freezing, storing, and administering therapeutic eukary- otic cells to a patient in need thereof. In many embodiments, the disclosed therapeutic cells are mammalian cells derived from human intervertebral disc tissue. The disclosed compositions, methods, and devices are able to maintain high viability and sterility of the therapeutic cells, and allow the cells to be administered to a patient directly from the freezing container without manipulation of the cells or transferring to a second container. [Continued on next page] WO 2018/160991 Al MIDEDIMOMOIDEIREEMOMOHINIECHIHOIRVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))