Patent SG-11201805906W-A (SG)
Title: Diagnostic and prognostic methods for cardiovascular diseases and events
Inventor: RHYNE RHONDA FAY
IPC: G01N33/68
Filed: 2017-02-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111 HO 11111 011101110011001111100111 111E1111 MI International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/136464 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every G01N 33/68 (2006.01) A61B 5/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/US2017/016081 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 1 February 2017 (01.02.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 62/289,513 1 February 2016 (01.02.2016) US 62/378,535 23 August 2016 (23.08.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PREVENCIO, INC. [US/US]; 11335 NE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 122nd Way, Suite 105, Kirkland, Washington 98034 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: RHYNE, Rhonda Fay; 6424 Lake Washington TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Blvd NE, #13, Kirkland, Washington 98033 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MAGARET, Craig Agamemnon; 2534 NE 83rd Street, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Seattle, Washington 98115 (US). STROBECK, John Ed- GW, KM, ML, MR, NE, SN, TD, TG). — ward; 59 West Saddle River Road, Saddle Ridge, New Jer- — sey 07458 (US). JANUZZI, James Louis Jr.; 83 Pilgrim Declarations under Rule 4.17: _ = Road, Wellesley, Massachusetts 02481 (US). — — as to applicant's entitlement to apply for and be granted a (74) Agents: SHERIN, Mridula P. et al.; Cooley LLP, 1299 patent (Rule 4.1700) Pennsylvania Avenue, NW, Suite 700, Washington, Dis- trict of Columbia 20004 (US). = = [Continued on next page] (54) Title: DIAGNOSTIC AND PROGNOSTIC METHODS FOR CARDIOVASCULAR DISEASES AND EVENTS = = (57) : Compositions and methods = are provided for diagnosis and/or prognos - Figure 1 is of cardiovascular diseases or events in a = -- subject. In some embodiments, the method = __ = = = E = g J s to = = _ E 1-- _ 1-1 __ includes measuring and comparing the level of particular proteins to other pro- teins. In other embodiments, the method includes comparison with clinical variable information. .4 4 € € 0.0 02 OA O6 OA 1,0 71' False poslfive rate 71' (MC . 0,872) M Il IN Il 0 ei O WO 2017/136464 Al 1#1101MOMOIDEIROIDEDE111101100111100IMMOVOIS — as to the applicant's entitlement to claim the priority of Published: the earlier application (Rule 4.17(iii)) — with international search report (Art. 21(3))