baber/WOPTO huggingface dataset:
Patent DO-P2015000050-A (DO)
Title: Polipéptidos que contienen fc con glicosilación alterada y función efectora reducida
Inventor: QIU HUAWEI
IPC: C07K16/28
Filed: 2015-03-05
Abstract: Se proporcionan polipéptidos de unión (p.ej., anticuerpos), y conjugados de fármaco de los mismos, que comprenden un dominio Fc con un perfil de glicosilación alterado y una función efectora reducida. En una realización particular, el dominio Fc comprende: un residuo de asparagina en la posición de aminoácido 298, según la numeración EU; y un residuo de serina o treonina en la posición de aminoácido 300, según la numeración EU. También se proporcionan ácidos nucleicos que codifican los polipéptidos de unión a antígeno, vectores de expresión recombinante y células hospedantes para preparar dichos polipéptidos de unión a antígeno. También se proporcionan métodos de uso de los polipéptidos de unión a antígeno descritos en la presente memoria para tratar una enfermedad.
Patent EC-SP10010610-A (EC)
Title: Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina
Inventor: BOARDMAN KAY ALISON
IPC: A61K31/517
Filed: 2010-11-15
Abstract: Difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(N-metilcarbamoilmetil) piperidin-4-il]oxi}quinazolina, composiciones farmaceuticas que contienen el difumarato, el uso del difumarato en el tratamiento de trastornos hiperproliferativos como el cancer y procesos para la fabricacion del difumarato son descritos.
Patent EC-SP11011485-A (EC)
Title: Espiro-epóxidos como productos intermedios.
Inventor: SCUTT JAMES NICHOLAS
IPC: C07D309/32
Filed: 2011-11-25
Abstract: La presente invención proporciona compuestos de fórmula I (I), en donde los sustituyentes son como se definen en la reivindicación 1. Los compuestos son productos intermedios apropiados para la preparación de 4-fenil-3,5-pirandiones, 4-fenil-3,5-tiopirandiones y 6-fenilciclohexano-1,3,5-triones activos como herbicidas.
Patent EG-25399-A (EG)
Title: Apparatus for producing synthesis gas.
Inventor: ZANICHELLI LUCA
IPC: B01J8/02
Filed: 2008-07-07
Granted: 2011-12-27
Abstract: An apparatus (1) for producing synthesis gas is described comprising a substantially cylindrical shell (2) closed by opposite bottoms (3, 4), at least one inlet opening (8) for feeding a gaseous flow comprising oxygen, at least one inlet opening (7) for a gaseous flow comprising hydrocarbons and at least one outlet opening for a flow of synthesis gas and at least one burner (9) in fluid communication with a reaction chamber (15) for partially oxidising and/or reforming said hydrocarbons obtaining said flow of synthesis gas, the apparatus being characterised in that it comprises a pipe (12) of ceramic material substantially coaxial with said shell (2) and defining an annular interspace (13) with it, said pipe (12) of ceramic material being externally coated with a coating (14) of ceramic fibres so as to substantially fill said annular interspace (13) and internally defining said reaction chamber (15).
Patent GB-189701077-A (GB)
Title: Improvements in Gauge-glass Fittings for Sight-feed Lubricators, Steam Boilers, and the like.
Inventor: WAKEFIELD CHARLES CHEERS
Filed: 1897-01-14
Granted: 1897-11-13
Abstract: 1077. Wakefield, C. C. Jan. 14. Gauge - glass fittings.-The gauge glasses may be inserted, secured, and removed b the mere detachment of a single plug or cap. This cap is shown at F screwed into the upper mounting E. The cap is recessed so as to contain a packing-ring G bearing upon the glass D.
Patent GB-189705791-A (GB)
Title: Improvements in Cooling Apparatus Combined with Centrifugal Milk Separators.
Inventor: SALENIUS ERIK GUSTAF NICOLAUS
Filed: 1897-03-04
Granted: 1897-05-08
Abstract: 5791. Salenius, E. G. N. Jan. 8, [date claimed under Sec. 103 of Patents &c. Act, A.D. 1883]. Cooling liquids.-The milk and cream from a separator are treated in a cooler from which the cooling-medium is taken to a second cooler for treating the milk before separation. Fig. 2 shows a section of a suitable cooler, in which the milk flows through the annular space q and the cooling- medium through the inner cylinder o and casing u.
Patent GB-189706712-A (GB)
Title: Improvements in or relating to Oil Filters.
Inventor: SMITH BENJAMIN
Filed: 1897-03-15
Granted: 1897-07-17
Abstract: 6712. Smith, B. March 15. Filtering oils. - H is a funnel containing a strainer I into which the oil is poured. The neck of the funnel is coupled to a tube g' which is perforated at the end and secured to the bottom of a vessel G. The vessel G has a false bottom i<1> supporting asb e s t o s filtering - medium g<1>, through which the oil passes upwards and falls through a layer of asbestos cloth C into a second funnel D which is coupled to a tube d<2> attached to the bottom of a vessel E. The vessel E is covered with asbestos cloth e<1>, through which the oil passes upwards and is finally collected in a chamber F.
Patent GB-189708263-A (GB)
Title: Improvements in Combined Hot and Cold Water Taps.
Inventor: BAXENDALE LABAN
Filed: 1897-03-31
Granted: 1898-03-26
Abstract: 8263. Baxendale, L., and Sinclair, W. R. T. March 31. Mixing-valves. -Three valves are used in combination with a casing C having two outlets E and F leading to a spray, shower, or douche, and a bath respectively. The supply of hot and cold water is regulated by the screwdown valves A and B, respectively, and passes through the outlet E or F according as the middle screw-down valve is in its lowest or highest position. When the valve is its mid-position, water flows through both outlets. Screw-down valves are preferred, but other forms which will effect the same purpose may be employed.
Patent GB-189708981-A (GB)
Title: Dual-exhaust Steam Locomotives.
Inventor: TODD LEONARD JENNETT
Filed: 1897-04-08
Granted: 1898-03-05
Abstract: 8981. Todd, L. J. April 8. Cylinders; pistons ; valves, distributing.- Consists of designs of cylinders and valves, for both inside and outside cylinder locomotive tramway engines, in which a portion of the exhaust escapes through ports uncovered by the main piston and a portion through the exhaust ports at the ends of the cylinder. The long piston required is composed of two parts A, A separated by a light distancepiece, and at the end of each stroke uncovers the ports C. The valves B, B are of the piston type.
Patent GB-189709044-A (GB)
Title: A New or Improved Automatic Loom Shuttle Guard.
Inventor: CROMPTON LAZARUS
Filed: 1897-04-09
Granted: 1898-03-05
Abstract: 9044. Crompton, L., and Turner, W. April 9. L o o m shuttle guards.-A rod B is cranked at its ends to be mounted in bearings U, and is provided at one end with an arm D having a pin L to receive an elastic band or spiral spring G, the other end of which is attached to a pin M on the bracket H. The other end has a stop lever, and the bearings also have stops, to determine the operative position of the rod. The rod is pressed under the lay cap to put it out of action, and comes intc action automatically when the loom is re-started.
Patent GB-189709113-A (GB)
Title: Improvements in or relating to the Attachment of Woodwork or Fixtures to Walls or Parts of Buildings.
Inventor: THIEKE AUGUST
Filed: 1897-04-09
Granted: 1897-06-12
Abstract: 9113. Thieke, A. April 9. Walls.-Wood plugs a, for securing skirtings, wainscotting, and woodwork to walls, are fixed in place by metal plates b b which are fastened by nails c, or wire netting e embedded in the plaster.
Patent GB-189709311-A (GB)
Title: Improvements in and relating to Mucilage Bottles or Receptacles.
Inventor: MCCOLLAM PATRICK GEORGE
Filed: 1897-04-12
Granted: 1897-06-12
Abstract: 9311. McCollam, P. G. April 12. Bottles &c.-The neck 6 of the mucilage bottle or vessel 5 is fitted internally with a tube 7, which is formed with a flange 9 adapted to remove surplus mucilage from the brush, and with a flange 11 to which the cover 12 is pivoted by the pin 14. The tube 7 is provided with a spring yoke 10 adapted to support the handle of the brush when not in use, and a corresponding recess 15 is formed in the cover 12 for the passage of the handle.
Patent GB-189713071-A (GB)
Title: Improvements in Thread Sizing and Polishing Machines.
Inventor: GRIFFITHS ALFRED
Filed: 1897-05-27
Granted: 1898-04-30
Abstract: 13,071. Griffiths, A., and Guest, T. May 27. Threads, sizing and polishing.-Relates to apparatus such as is described in Specification No. 15,324, A.D. 1892. The brackets v, 0, for carrying the rollers b, c, round which the threads pass, are laterally adjustable towards and from the brushing and polishing drum k; and the roller b is driven from the main shaft j through a belt, spur-wheels b<4>, b<5>, b<6>, of which b<6> is a change-wheel, and a chain b<8>. The spur-wheels b<5>, b<6> are carried by an adjustable sector b<10> to allow the tightening of the chain b<8>. The roller a in the size trough is driven by a belt from the roller b, the roller c is dragged round by the threads, and the lifting- motion is driven through worm gearing, as shown. The spindles are driven by belt and bevel gearing from the shaft j.
Patent GB-189714791-A (GB)
Title: Improvements in Machines for Making Doubled or Folded and Twisted Bands or Cords employed for Driving the Spindles of Spinning and Twisting Machines, and the like.
Inventor: COLE HENRY STUDLY
Filed: 1897-06-18
Granted: 1897-09-18
Abstract: 14,791. Cole, H. S. June 18. Driving - c o r d s.- Consists of a machine for making doubled or folded and twisted 'loop-bands' or cords employed for driving the spindles of spinning and twisting machines &c. A length of yarn is drawn from a spool u and formed into a loop by pins a<8> on a travelling carriage B. The ends of the loop are now held by two pairs of jaws or pincers, which can each rotate on its axis, or they can both rotate round a common centre, and the length of yarn is severed from the spool. Each half of the loop is now twisted by reason of the jaws rotating each on its own axis, and, towards the end of this twisting movement, the two pairs of jaws rotate about a common axis so as to lay and twist the two ends of the loop together. The completed band is released from the machine, seized by a pair of jaws carried by a rotating rod d', and delivered into a suitable receptacle. All the operations are performed automatically, and the carriage when at the extremity of its traverse is held by weighted cords &c., so that it may yield as the 'loop band' shortens during the twisting operation.
Patent GB-189718721-A (GB)
Title: Improvements in Detachable Heels for Boots and Shoes.
Inventor: MAEBERT ALEXANDER
Filed: 1897-08-12
Granted: 1898-01-01
Abstract: 18,721. Maebert, A. Aug. 12. Heels.-Consists of a method of attaching a heel so that it can easily be removed when worn and another put in its place. To the sole is screwed a metal plate 7, the edge of which is curled inwards, as shown at 9. Towards the front is a loose tongue 11, on each side of which at 16 a piece 15 is punched out to form a flange, as shown in Figs. 4 and 5. A metal plate 19 is screwed to the heel, and is slit at each side, as shown at 21 in Fig. 3. A tongue 25 is also punched out, depressed, and secured by a screw 26. The heel is slid into the position shown in Fig. 2 from the front, and secured by a pin 28 in the tongue 11. In a modified arrangement, the plate on the heel is dispensed with.
Patent GB-189722612-A (GB)
Title: Improvements in Chimney Pots and Ventilators.
Inventor: GREEN JOHN JOHNSTON
Filed: 1897-10-02
Granted: 1898-08-13
Abstract: 22,612. Green, J. J. Oct. 2. Chimney and ventilating-shaft tops.- A plane uptake section a is surmounted by a succession of conical rings band half-round rings c, the order of which may be inverted.
Patent GB-189722914-A (GB)
Title: Pneumatic Spring Arrangement for the Frames of Cycles.
Inventor: HARRISON WILFRED HARTLEY
Filed: 1897-10-06
Granted: 1898-06-11
Abstract: 22,914. Harrison, W. H. Oct. 6. Forks; frames; steering-mechanism.-Relates to anti-vibration arrangements. Fig. 1 shows the application to a bicycle steering-head. A pneumatic ring F is carried between a plate G, secured to a tube B which slides in the steering-post E, and a plate D, formed on the lower bearing-cup as shown. A rod J, passing up to the handle-bars, and screwed into a block K secured in the tube B, keeps the parts in position when the front wheel is raised above the ground. A block M secured in the tube B engages slots in the steering-post K to enable the cycle to be steered. Figs. 3, 4, and 5 show the application to the rear wheel. The back stays H are connected to a tube B, sliding in a tube A and provided with a pneumatic ring as above. The lower ends of the stays H are forked as shown in Fig. 5 to fit on the wheel axle. This axle is mounted free to slide in vertical slots formed in a piece P, which is adapted to be adjusted on guides on the chain stays by a screw V and lock nuts W, as shown, thereby adjusting the chain.
Patent GB-189723256-A (GB)
Title: Improved Ball Bearings for Bicycles and other Vehicles.
Inventor: SMALLMAN JAMES WILLIAM
Filed: 1897-10-09
Granted: 1898-08-20
Abstract: 23,256. Smallman, J. W. Oct. 9. Ball bearings for wheels and other parts of velocipedes and other vehicles. The adjusting- cup B is prevented from turning by lugs b engaging in slots in the hub or casing A. The lugs are embraced by nuts C, C', and adjustment is effected by loosening one nut and screwing up the other. An oil-retaining cup G may be substituted for the outer nut as shown in Fig. 11. When the cups B face inwards, as shown in Fig. 3, both cones E are secured to the axle. When the cups face outwards, as shown in Fig. 11, the cone K is made removable.
Patent GB-189724519-A (GB)
Title: Improvements in the Construction of Overhead Lines of Electric Railways or Tramways.
Inventor: DAWSON PHILIP
Filed: 1897-10-22
Granted: 1898-08-27
Abstract: 24,519. Dawson, P. Oct. 22. Electric railzvays and tramways with overhead conductors. Conductors, crossings and frogs for. Figs. 1 and 2 show the underside and top in plan of a crossing. The underside has ribs A<1>, A', grooves a, and guards a' to guide the trolley wheel, and preferably the ribs are curved and a central guide A<3> is also used. The ribs &c. are shaped so that the wheel runs on its flanges at the centre of the plate ; or the plate may be inclined or otherwise arranged to guide the trolleys. The conductor wires are not cut, but are held in grooves a<2> on the top side of the plate by solder and by clamps and set-screws.
Patent GB-189729989-A (GB)
Title: Improvements in Trousers.
Inventor: COOMBE SAMUEL
Filed: 1897-12-18
Granted: 1898-04-30
Abstract: 29,989. Coombe, S., and May, J., [trading as Coombe & May]. Dec. 18. Trousers; knickerbockers.-Trousers can be temporarily converted into knickerbockers by turning them up at the bottoms and drawing them up the legs so that the turned-up part comes immediately below the knee, in which position they can be held in place by a fastening or strap. There is then placed over the turned-up part a band which may be made as shown in Fig. 2, or may be an endless band, Fig. 3, of knitted material or with elastic insertions 3. The buttonhole 4, Fig. 2, may be fastened on to a button on the trousers.
Patent GB-189730752-A (GB)
Title: Automatic Gripping Apparatus for Attaching Suspended Loads to Overhead Hauling Ropes for Aerial Cable Lines.
Inventor: FRIGARD JULIO
Filed: 1897-12-29
Granted: 1898-04-30
Abstract: 30,752. Frigard, J. Dec. 29. Rope railways and tramways; rope grips. - A box A pivoted in the hanger G contains two loose jaws B of the form shown in plan and side view in Figs. 5, 6, and 7. A locking- bolt sliding in the top of the box A is shot by a cam attached to a looped handle F to engage the jaws B when they grip the rope. The grip is engaged with or disengaged from the rope by the aid of fixed rails K and wheels J on the hanger G. The sheave H has three grooves, one for the rope and the others to allow the edges of the jaws B to pass. The gripping-surfaces of the jaws are shaped to correspond with the strands of the rope.
Patent GB-189809592-A (GB)
Title: Improvements in Shoes for Horses or other Hoofed Animals.
Inventor: POUPARD FREDERICK ABRAHAM
Filed: 1898-04-26
Granted: 1899-04-26
Abstract: 9592. Poupard, F. A. April 26. Fixing.-Relates to improvements on the invention described in Specification No. 10,009, A.D. 1897. The nailless shoe A is secured by malleable clips B and studs C placed opposite to them so that a dovetailed portion of the hoof is gripped between them. The clips are arranged one at the toe and one at the outer end, or both ends of the largest diameter of the shoe or on the front side of this line. The studs have chisel points and are shouldered. They are kept in place by burring over the metal at the upper ends of the stud holes so as to engage the shoulders.
Patent GB-189813459-A (GB)
Title: The Manufacture and Production of Preparations of Salicylic Acid suitable for Surgical Antiseptic Purposes.
Inventor: WILLCOX Benjamin
Filed: 1898-06-16
Granted: 1899-04-22
Abstract: 13,459. Willcox, B., [Vereinigte Chininfabriken Zimmer & Co.]. June 16. Antiseptics.-Relates to dry antiseptics composed of new preparations of salicylic acid with the rare earths. The new bodies specified are didymium and lanthanum salicylates, which may be prepared separately or mixed by either of the following methods :-(1), acting on a soluble salt or soluble salts of the rare earth or earths with a salicylate, and, (2), acting on the hydrate or car. bonate of the rare earth or earths with salicylic acid. The new salts are insoluble, and didymium salicylate is a pale pink powder.
Patent GB-189815534-A (GB)
Title: Improvements in Safety Guards for Chaff-cutting Machines.
Inventor: FIELDING WILLIAM
Filed: 1898-07-15
Granted: 1898-10-29
Abstract: 15,534. Fielding, W. July 15. Guards for chaff-cutters. A board or plate c is mounted at its inner end upon the spindle of the top feed-roller b<1>, and at its outer end rests upon t!.e top of the feed-trough a. Side rods or links f serve to limit the upward movement.
Patent GB-189816096-A (GB)
Title: An Improved Waste Water Closet Pan.
Inventor: PICKUP WILLIAM ROSTRON
Filed: 1898-07-23
Granted: 1899-05-20
Abstract: 16,096. Pickup, W. R, July 23. Closet basins for waste-water closets. The outlet b is placed eccentrically in the basin by the side of the inlet c. The water as it rushes round the basin is detained in a circular channel by a ridge d.
Patent GB-189817080-A (GB)
Title: Improvements in Electrical Transcribing Apparatus.
Inventor: HUMMEL ERNEST AUGUST
Filed: 1898-08-08
Granted: 1899-08-08
Abstract: 17,080. Hummel, E. A. Jan. 10, [date applied for under Sec. 103 of Patents &c. Act, A.D. 1883]. Telegraphs.--Facsimile or copying telegraphs are arranged with motor-driven cylinders C both at the transmitting and receiving stations. The transmitter is provided with a copy in insulating-ink such as shellac on a metal surface, and this is traversed by a style 33 mounted in the guide D, and is moved forward by the screw 28 after each revolution of the cylinder. Fig. 4 shows an elevation of the transmitter releasing and feeding mechanism. A locking-disc 14 is provided with a detent notch 13, a contact-block 21 with a V-recess 27 for momentarily breaking the main line circuit at each revolution, and a pawl 44 for operating one of the spur-wheels 36, 37, 38 having differing numbers of teeth on the screw shaft. The lever 10, 12, 18 is the hand releasing-mechanism, and the lever 23, 24 is the contact-lever playing between the stops 25, 26. In the receiving-instrument the recording-style is operated by a local relay circuit containing an electromagnet, and the releasing-arm is also provided with an electromagnet. The relays are reversed so as to produce a positive record.
Patent GB-189817490-A (GB)
Title: Improvements in Focussing Photographic Cameras.
Inventor: TEED HARRY WILLIAMSON
Filed: 1898-08-13
Granted: 1899-06-17
Abstract: 17,490. Teed, H. W. Aug. 13. Cameras.-Relates to a device of the same kind as a range-finder for focussing in photographic cameras. The lens is attached to the slide B. When the lens and slide B are moved, they displace through a lever R pivoted at S the slide D. On this slide D is a screw T, the point of which acts on a cam surface of suitable shape on the arm E. The arm E rotates a mirror G, which throws an image of the object to be photographed on the mirror H. Only half of the surface of H is silvered, the other half being transparent, so that part of the object can be seen directly through it by the finder F. When the reflected part of the object coincides with the part seen directly, then the plate &c. is in focus.
Patent GB-189823994-A (GB)
Title: Improvements in Feed Bags and Supporting the same.
Inventor: WEIDEZAHL HERMAN GEORG
Filed: 1898-11-14
Granted: 1899-03-25
Abstract: 23,994. Weibezahl, H. G. Nov. 14. Drawings to Specification. Sacks and like bags. - Nosebags, preferably waterproof, are stated to be applicable for carrying other articles besides the fodder. The mouth of the bag is closed by a hinged ring.
Patent GB-189901320-A (GB)
Title: Improved Driving Gear for Velocipedes.
Inventor: HACKMAN WILLIAM FRANCIS
Filed: 1899-01-19
Granted: 1899-11-25
Abstract: 1320. Hackman, W. F. Jan. 19. Toothed gearing; crank linkages.-Relates to driving-mechanism for cycles. Fig. 2 shows a part sectional plan of the mechanism. The crank axle A carries an internal wheel B, which actuates a pinion C on a shaft D carrying cranks e, e<1>. These cranks are connected by rods E, E<1> passing through the hollow stays M with eccentric straps F, F<1> encircling eccentrics on the driving-wheel hub. The crank ends are divided and are fitted with adjustable ball bearings, and the straps F are also provided with ball bearings as shown. The stays Mare made sufficiently deep to allow for the play of the connecting-rods. The cranks e, e<1> are arranged at right-angles. The shaft D is mounted in the bottom bracket K, and the driving-wheel turns on a fixed axle N as usual.
Patent GB-189904478-A (GB)
Title: Improvements in Boots and Shoes.
Inventor: VIANELLO ATTILIO
Filed: 1899-03-01
Granted: 1899-04-29
Abstract: 4478. Vianello, A. March 1. Repairing; soles; uppers; sole and heel protectors; nailing and riveting.-Relates to boots and shoes which can readily be taken to pieces so that damaged parts may be replaced. The back quarters a, a are secured to the sole d, while the front portion f of the upper is secured to the insole h, and is provided with a welt g. The welt g and sole d have rectangular perforations e, i round their edges, while the half-sole or clump s, Fig. 4, has conical holes,j, j corresponding to the perforations e, i. In putting a shoe together, the clump s is placed under the sole d, and secured by nails driven through the perforations x, x. The insole h is then placed over the sole d, so that the perforations e, i, and j coincide. Aluminium or other metal nails are driven through them until their conical heads rest in the holes j, j, after which they are clinched over the welt. The front and back of the upper are secured by straps k, Fig. 5, laced through slits m and n. The heel portion of the insole may be placed under a sock t. The top piece of the heel has metal plugs q, q secured in conical holes, and the clump may have metal-headed nails riveted over washers on its, inner side. With each pair of shoes is supplied a pair of upper fronts, a pair of clumps, two pairs of straps k, and a number of nails for repairing them.