Patent SG-11201803942Q-A (SG)
Title: T-cell receptor and uses thereof
Inventor: LEE STEVEN P
IPC: C07K14/725
Filed: 2016-11-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau (43) International Publication Date C..2' 26 May 2017(26.05.2017) WIPO I PCT ID Hit (10) WO International 2017/085471 111111111111111111IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIIIIIIIIII Publication Number Al (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, C07K 14/725 (2006.01) A61K 38/17 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/GB2016/053566 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 15 November 2016 (15.11.2016) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (25) Filing Language: English ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 1520191.6 16 November 2015 (16.11.2015) GB GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: CANCER RESEARCH TECHNOLOGY TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, LTD [GB/GB]; Angel Building, 407 St. John Street, Lon- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, don, Greater London EC1V 4AD (GB). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventor: LEE, Steven P.; c/o Institute for Immunology SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, and Immunotherapy, University of Birmingham, Vincent GW, KM, ML, MR, NE, SN, TD, TG). Drive, Edgbaston, West Midlands B15 2TT (GB). Declarations under Rule 4.17: (74) Agent: HGF LIMITED; Document Handling - (HGF) — of inventorship (Rule 4.17(iv)) York, 1 City Walk, Leeds, Yorkshire LS11 9DX (GB). Published: (81) Designated States (unless otherwise indicated, for every 21(3)) with international search report (Art kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (54) Title: T-CELL RECEPTOR AND USES THEREOF FIGURE 1 ( SEQ ID No . 1 ) 1-1 .4t MK R I LGAL EG ELSWICMIR G = QVE QS P P I) L I I, QE GAN S T LRCM FSIDe VN NI.,QMitHQNEW GQ - 1,11: NEE Y.1: P S (TEE QNGRIL S KIE11:VAT KEYS 1:4LY I S SS 1-1 IN DSGVYFCAVV ENNDMRFGAG TRLTVKPN170 NPDPAVYQLP DSKSSOKSVC ll• LET DEDSQTN VSQSKESEVY I T DKCVLDNR SMDEKSNSAV AWSNKSDFAC In ANAENNSTIP EDTFETSPES SCENFIVEKS FETETNLNFQ NLSVIGFRIL GO 0 IIKVAG FN EL MTLRIMSS --.... IN 1-1 (57) : The present invention relates to a T-cell receptor comprising: a) an alpha chain comprising an amino acid sequence as N set forth in SEQ ID No.1 or a functional equivalent thereof; and/or b) a beta chain comprising an amino acid sequence as set forth in SEQ ID No.2 or a functional equivalent thereof; as well as uses thereof including in the treatment of an EBV+ tumour.