Patent SG-11201808944Q-A (SG)
Title: Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
Inventor: GRAUPE MICHAEL
IPC: C07D401/14
Filed: 2017-08-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MD HIM 0 11101 HOE 3E1 0 01111111011101110110HONIO HI International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/035359 Al 22 February 2018 (22.02.2018) WIP0 I PCT (51) International Patent Classification: Drive, Foster City, CA 94404 (US). SCHROEDER, Scott CO7D 401/14 (2006.01) A61K 31/4439 (2006.01) D.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Fos- A61P 31/18 (2006.01) ter City, CA 94404 (US). STEFANIDIS, Dimitrios; c/o (21) International Application Number: Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA PCT/US2017/047416 94404 (US). TSE, Winston C.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). ZHANG, (22) International Filing Date: 17 August 2017 (17.08.2017) Jennifer R.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). (25) Filing Language: English (74) Agent: LO, Karen et al.; Gilead Sciences, Inc., 333 Lake- (26) Publication Language: English side Drive, Foster City, California 94404 (US). (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/377,312 19 August 2016 (19.08.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/457,555 10 February 2017 (10.02.2017) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicant: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, CA 94404 (US). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, — (72) Inventors: GRAUPE, Michael; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). HENRY, Steven J.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, Foster City, CA 94404 (US). LINK, John 0.; c/o Gilead TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 = (US). ROWE, Charles William; c/o Gilead Sciences, Inc., (84) Designated States (unless otherwise indicated, for every 333 Lakeside Drive, Foster City, CA 94404 (US). SAI- kind of regional protection available): ARIPO (BW, GH, = TO, Roland D.; c/o Gilead Sciences, Inc., 333 Lakeside GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — = (54) Title: THERAPEUTIC COMPOUNDS USEFUL FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF AN HIV INFECTION VIRUS F F (57) : The present disclosure relates to a compound of formula (Ia), (Ib), (Ha), and (IIb): (Ia) = 1 * (lb) (IIa) (IIb) which are useful in the treatment of a Retroviridae viral infection including an infection N caused by the HIV virus. cl . = = ,,, F - _ C I 11a) = - F F • 11 10 = N I 0 CI O N = / N = — 1- (lb) = 401 ,' l F 1-1 ,. 8 N 1,1 F C:7 11 in M 11 in en F (L1b) ,, 4 0 © \ ... g, N° Il F © ei (116) C [Continued on next page] WO 2018/035359 Al MIDEDIMOMOIDEIREIHNIOMEMMECHIMin UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))