Patent SG-11201408739V-A (SG)
Title: Inhibitors of hepatitis c virus
Inventor: BJORNSON KYLA
IPC: A61P31/14
Filed: 2013-07-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/008285 A1 (51) International Patent Classification: C07D 491/18 (2006.01) A61K31/4995 (2006.01) A61P 31/14 ( 2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/049119 2 July 2013 (02.07.2013) English English (30) Priority Data: 61/667,806 61/798,524 3 July 2012 (03.07.2012) 15 March 2013 (15.03.2013) (71) Applicant: GILEAD SCIENCES, INC. [US/US]; Lakeside Drive, Foster City, CA 94404 (US). US US 333 (72) Inventors: BJORNSON, Kyla; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). CANALES, Eda; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). COTTELL, Jeromy, J.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). KARKI, Kapil, Kumar; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). KATANA, Ashley, Anne; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). KATO, Darryl; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). KOBAYASHI, Tetsuya; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). LINK, John, O.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). MAR­ TINEZ, Ruben; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). PHILLIPS, Barton, W.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). PYUN, Hyung-jung; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). SANGI, Michael; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). SCHRIER, Adam, James; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). SIEGEL, Dustin; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). TAYLOR, James, G.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). TRAN, Chinh, Viet; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). TREJO MARTIN, Teresa, Alejandra; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). VIVI­ AN, Randall, W.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). YANG, Zheng-Yu; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). ZABLOCKI, Jeff; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). ZIPFEL, Sheila; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). (74) Agent: TANNER, Lorna L.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, CA 94301- 1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, [Continued on next page] (54) Title: INHIBITORS OF HEPATITIS C VIRUS N^G oo CJ 00 o o o CJ (57) Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed. WO 2014/008285 A11II llll IIII III III Hill III III III Hill Hill lllll lllll llll 111 mill llll 111 llll MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))