Patent SG-11201900200X-A (SG)
Title: Tgfb antibodies, methods, and uses
Inventor: CARVEN GREGORY J
IPC: C12N9/00
Filed: 2017-07-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 0 11101 HOE 3E1 0 01111110111 00111111 001110 11110 IIE OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/013939 Al 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: (US). TURNER, Katherine; 4 Hazelnut Street, Acton, A61K 38/18 (2006.01) C07K 16/22 (2006.01) Massachusetts 01720 (US). A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 39/395 (2006.01) Cl 2N 9/00 (2006.01) (74) Agent: SHIRTZ, Joseph F. et al.; JOHNSON & JOHNSON, One Johnson & Johnson Plaza, New (21) International Application Number: Brunswick, New Jersey 08933 (US). PCT/US2017/042162 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 14 July 2017 (14.07.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (25) Filing Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (26) Publication Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (30) Priority Data: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/362,393 14 July 2016 (14.07.2016) US August 2016 (05.08.2016) US 62/371,355 05 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: SCHOLAR ROCK, INC. [US/US]; 620 TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Memorial Drive, Cambridge, Massachusetts 02139 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: CARVEN, Gregory J.; 89 Brooks Street, May- kind of regional protection available): ARIPO (BW, GH, — nard, Massachusetts 01754 (US). SCHURPF, Thomas; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 620 Memorial Drive, Cambridge, Massachusetts 02139 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = = (54) Title: TGFB ANTIBODIES, METHODS, AND USES = = = Figure 1 = = = Teri Teff Treg = = — = = = = :I 'S * .; . @cm 213-1C1 IM 43-1669 I = e _ ug/mL = * p < 9 01 when compared to IgG con i 1 - using Durtnette 1-way ANOVA 11 C:r M C:r M 1-1 (57) : ProTGFB1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFB1-GARP com- = - plex-selective antibodies or antigen-binding fragments, cells expressing proTGFB1-GARP complex-selective antibodies or anti- GC gen-binding fragments, as well as associated vectors and detectably labeled proTGFB1-GARP complex-selective antibodies or anti- 1-1 © gen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer. ei o [Continued on next page] WO 2018/013939 Al MIDEDIMOMOIDEIREEMOOMMOIIIMMIIMIDEVOIS TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))