baber/WOPTO huggingface dataset:
Patent CA-2329519-A1 (CA)
Title: In vitro maintenance of hematopoietic stem cells
Inventor: THIEDE MARK A
IPC: A61K48/00
Filed: 1999-06-08
Abstract: The present invention is directed to human mesenchymal stem cells isolated from a tissue specimen, such as marrow cells, and to the method of co-culturing isolated mesenchymal stem cells and/or mesenchymal stem cell-derived adipocytes with hematopoietic progenitor cells such that the hematopoietic stem cells retain their phenotype.
Patent CA-2329943-A1 (CA)
Inventor: ANN QINGHONG JESSICA
IPC: C09D7/12
Filed: 1999-04-14
Abstract: This invention relates to complexes of ultraviolet absorbers with quaternary ammonium compounds which are substantially free from unwanted salts. Such complexes are formed through ionic bonds formed between the two compounds. The inventive complexes are then removed of substantially all excess inorganic salt so as to obtain a UV absorber compound which exhibits improved light- and washfastness properties, which easily coats subject surfaces, which provides excellent non-fogging and non-cracking characteristics, and which also possesses anti-static, anti-microbial, and anti-abrasion properties. This invention also concerns methods of making and utilizing such inventive ultraviolet absorbing complexes.
Patent CA-2330012-A1 (CA)
Title: Hub port without jitter transfer
Inventor: BREWER DAVID
IPC: H04J3/07
Filed: 1999-04-30
Abstract: A hub port (200) in a hub which preferably eliminates the transfer of fitter in the signal transmitted to an attached node port. In one embodiment, jitter transfer is preferably eliminated by transmitting data to an attached node port (212) using a local clock signal internal to the hub rather than a clock signal recovered from the datastream. The hub port includes smoothing circuits (220) to synchronize data received from the attached node port to the local clock.
Patent CA-2330406-A1 (CA)
Inventor: BRUNSCHWILER THOMAS
IPC: G02B6/125
Filed: 2001-01-10
Abstract: The optical waveguide coupler comprises a structure (1) of a number of elongated narrow optical waveguide strips (2), which consist respectively of a front area (3), a center area (4) and a coupling area (5). The center area (4) has respective transition areas (6) and (7) to the corresponding area (3) or (5).  A gap (9) in the front areas (3) provided between two adjoining strips (2) is larger than the thickness of the narrow strips (2). The front faces (8) of the front areas (3), and the front faces of the coupling areas (5) are embodied to be as smooth as possible, wherein all strips form a stack in the coupling area (5). The gaps are pits which result from etching of an Si substrate with the aid of a DRIE etching process.
Patent CA-2331670-A1 (CA)
Inventor: LYSEK BRUCE A
IPC: C08K9/08
Filed: 1999-08-13
Abstract: In situ polymerization of polyamide monomers and silicate materials followed  by solid state polymerization produces polyamide nanocomposite materials wit h desirable physical properties. The nanocomposite materials produced include homopolymers and copolymers. The properties of the nanocomposite materials m ay be varied by the choice of monomers, type of silicate, and polymerization conditions.
Patent CA-2334812-A1 (CA)
Inventor: NOEL JOSEPH P
IPC: A61P31/04
Filed: 1999-06-04
Abstract: The invention relates to inhibitors of PPIase activity and pharmaceutical compositions containing such inhibitors. Such compounds are useful for treatment of disorders characterized by inappropriate cell proliferation. In particular the compounds disclosed herein inhibit the activity of members of the Pin1/parvulin class of PPIases. These compounds have been designed based on the high resolution X-ray derived crystal structure of the human enzyme Pin1.
Patent CA-2334941-A1 (CA)
Title: Tnf-derived peptides for use in treating oedema
Inventor: FRANSEN LUCIE
IPC: A61K/
Filed: 1999-08-10
Abstract: The present invention relates to the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-.alpha.) can efficiently  be used to treat oedema. More specifically, the present invention relates to  the usage of peptides derived from the region of human TNF-.alpha. from Ser1 00 to Glu116 to treat pulmonary oedema. Moreover, the present invention concern s a circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC which is  very efficient in inducing oedema resorption.
Patent CA-2340286-A1 (CA)
Title: Plant expression vector comprising a 5' non-translated leader sequence from a wheat chlorophyll a/b-binding protein gene
Inventor: SANTINO COLLEEN G
IPC: C07K14/415
Filed: 1999-08-18
Abstract: Novel combinations of 5', 3' and intron genetic elements are provided for enhanced expression in transgenic plants. The elements are associated with a  fructose 1,6-bisphosphatase gene, a chlorophyll a/b binding protein gene, a ubiquitin gene, a nopaline synthase gene, and/or a heat shock gene. Recombinant DNA molecules containing the non-translated 5' and/or 3' non- translated elements of the invention are further provided, as are plant cell s, tissues and plants containing those DNA molecules.
Patent CA-2341719-A1 (CA)
Title: Infant safety device
Inventor: MORGILLO ANGELO
IPC: A47D13/08
Filed: 1999-08-25
Abstract: A safety device (2) for use in safely restraining an infant, particularly on a flat substrate, is described, the safety device (2) comprising a support portion (4) for supporting the body of the infant and a harness portion (20) for restraining the body of the infant in the supported position in which the harness (20) includes a number of flaps (16, 22, 24, 28) which co-operate with each other to envelop a part of the body of the infant, thereby restraining the infant. The device may be in the form of a U-pillow or in the form of a pillowcase for a U-pillow. In addition, the device is provided with a pocket (14) for storing the harness when not in use and for acting as a neck, head or shoulder rest by providing an extra thickness of padding.
Patent CA-2343641-A1 (CA)
Inventor: BUITRAGO JUAN A
IPC: C10N30/08
Filed: 2001-04-10
Abstract: A lubricating oil composition containing an additive composition comprising an alkali metal borate; an oil-soluble sulfur-containing compound; and a trialkyl phosphite, which improves the high temperature load-carrying properties in gears.
Patent CA-2344696-A1 (CA)
Inventor: VOORHEES JOHN J
IPC: A61P3/02
Filed: 1999-10-12
Abstract: The vitamin A metabolite all-trans retinoic acid (RA) is critical for normal  skin function. Ultraviolet irradiation (UV) markedly reduces the mRNA and protein of the two major nuclear retinoid receptors, RAR-.gamma. and RXR- .alpha. in human skin in vivo. One half the dose of UV that causes skin reddening was sufficient to reduce retinoid receptor mRNA levels. Maximal reduction of RAR-.gamma. and RXR-.alpha. proteins occurred between 8 and 16 hours after UV irradiation. With multiple exposures to UV, RXR-.alpha. remained decreased, but RAR-.gamma. recovered to normal levels. Application of RA 24 hours before UV exposure partially prevented loss of nuclear retinoid receptors. UV irradiation completely prevented RA induction of two retinoid receptor-regulated genes, cellular retinoic acid binding protein-II(CRABP-II ) and RA 4-hydroxylase. In contrast, UV irradiation did not affect 1,25- dihydroxyvitamin D3 induction of the vitamin D receptor-regulated gene, vitamin 0 24-hydroxylase, indicating that UV selectively interferes with the  retinoid-signaling pathway. These data demonstrate for the first time that U V specially reduces retinoid receptor levels and dramatically suppresses retinoid-responsive gene expression in human skin in vivo. In effect, UV causes a functional vitamin A deficiency that could have deleterious effects  on skin function, contributing to skin photoaging and carcinogenesis, which can be ameliorated by application of a retinoid prior to exposure.
Patent CA-2345238-A1 (CA)
Title: Fluid thrust bearing for indicating instruments
Inventor: ROSE VINCENT H
IPC: G01D11/12
Filed: 1999-10-18
Abstract: Fluid thrust bearing containing moving magnet indicating instrument (10) includes a bobbin (12) and transparent lens (14) through which pointer (16) and dial (18) can be viewed.      Pointer (16) is mounted to end of shaft (20) having axis of revolution (28) and attached to rotor (30) in bore (34). The rotor (30) is disposed in close-fitting walled cavity (26) so as to define a small substantially air excluded damping fluid filled gap (32) therebetween. Shown near detail arrows (1A) are excess fluid containing reservoir (33) formed by raised torroidal ridges (36,38). Indicator (10) contains two pairs of field coils (22.1, 22.2, 24.1, 24.2). Adhesion and cohesion help maintain the rotor (30) in cavity (26). The substantial air exclusion helps prevent rotor (30) from moving axially out of cavity (26). A method of assembling to create such conditions therein is also set forth.
Patent CA-2346024-A1 (CA)
Inventor: INGLE FRANK W
IPC: A61B5/20
Filed: 1999-10-12
Abstract: Cette invention se rapporte à des dispositifs, des systèmes et des procédés servant à diagnostiquer et/ou traiter l'incontinence urinaire et qui peuvent surveiller avec précision et de façon fiable à la fois une pression vésicale Pv) et une pression urétrale )Pm) maximum d'un patient durant une pulsation de pression abdominale, afin de déterminer les relations entre ces pressions. L'alignement entre la position de la pression urétrale (30) maximum et un capteur de pression (20, 22) d'un cathéter (18) peut être maintenu au moyen d'une structure d'ancrage (24) ayant une surface qui vient en contact avec une surface tissulaire le long du col de la vessie, de l'urètre (UR) ou du méat externe (EM), qui se déplacent avec l'urètre (U) pendant les pulsations de pression abdominales. Un diagramme de pression graphique est alors produit, de façon à illustrer l'augmentation de la pression urétrale par rapport à l'augmentation de la pression vésicale et ce diagramme est affiché à intervalles répétés en temps réel pour l'opérateur du système se trouvant à côté du patient. Les résultats diagnostiques quantitatifs et/ou qualitatifs permettent alors un remodelage sélectif de la structure de support du patient, en vue d'empêcher l'incontinence.
Patent CA-2346852-A1 (CA)
Inventor: CHUI KUI MING
IPC: A61B6/03
Filed: 1999-10-15
Abstract: On applique un procédé de déconvolution à une image (25) d'un objet balayé (23), que l'on produit par résonance magnétique, tomographie ou une autre technique, de manière à dériver la fonction d'étalement ponctuel (22') au niveau d'un bord-objet et à repérer à partir du point médian de sa demi-hauteur pleine-largeur (FWHM) l'emplacement (30) du véritable bord-image. Avec l'image-objet (25') qui se superpose à la fonction PSF (22') dans l'espace de déconvolution, les sous-pixels qui suivent l'emplacement (30) sont transférés à l'avant dudit emplacement en vue de la reconstruction du bord-image (25') de manière à obtenir une meilleure conformité avec le bord-objet (23). La définition précise du contour-image (37) permet d'effectuer une détermination précise de la surface et du volume des profils (35) d'images ainsi que leur segmentation. La définition précise des bords-images permet d'effectuer une correction viable de la distorsion géométrique dans un programme autonome de traitement et de diagnostic par résonance magnétique.
Patent CA-2347432-A1 (CA)
Title: Substrat d'electrode de carbone poreux, methode de production de ce substrat et papier a fibres de carbone
Inventor: HAMADA MITSUO
IPC: H01M4/96
Filed: 2001-01-25
Abstract: La présente invention concerne un papier à fibres de carbone caractérisé en ce qu'il comporte un composé de polymère organique en tant que liant et des fibres de carbone comprenant des fibres fines présentant une longueur moyenne entre 3 et 10 mm, un matériau d'électrode à base de carbone poreux pour piles à combustible présentant une épaisseur comprise entre 0,05 et 0,5 mm, une densité volumique de 0,3 à 0,8 g/cm<3>, une vitesse d'application à la contrainte de 10 mm/minute, une résistance à la flexion de plus de 10 MPa mesurée par essai de flexion en trois points à condition que la distance entre les supports soit de 2 cm et la largeur de la pièce d'essai soit de 1 cm, et la déflexion de flexion soit d'au moins 1,5 mm. L'invention concerne également un procédé de production d'un matériau d'électrode à base de carbone poreux pour piles à combustible par l'imprégnation de papier à fibres de carbone avec une résine thermodurcissable (la prise de la résine thermodurcissable s'effectuant par le réchauffement sous pression, et la carbonisation de la résine font aussi partie de l'invention). Le matériau de base d'électrode présente une mollesse excellente et une excellente résistance à la flexion, et peut être en rouleau et produit à haute cadence. Le papier à fibres de carbone est particulièrement utile pour la fabrication de matériau de base d'électrode
Patent CA-2347776-A1 (CA)
Title: Dispositif electroluminescent a auto-balayage
Inventor: YAMASHITA KEN
IPC: B41J2/45
Filed: 2000-08-23
Abstract: L'invention concerne un dispositif électroluminescent à auto-balayage dont la quantité de lumière peut être répartie de manière uniforme dans une ou plusieurs puces électroluminescentes par correction de la quantité de lumière d'un élément électroluminescent. On corrige la quantité de lumière de cet élément électroluminescent par régulation du temps d'électroluminescence de l'élément électroluminescent, ou par régulation de la tension d'un signal d'écriture envoyé vers cet élément électroluminescent. La qualité d'impression d'une tête imprimante optique faisant intervenir ce dispositif électroluminescent à auto-balayage peut être améliorée grâce à cette répartition uniforme de la quantité lumière.
Patent CA-2348874-A1 (CA)
Title: Catalyst of a heteropoly acid salt on a non-metallic porous support and process for preparation thereof
Inventor: PEDEN CHARLES H F
IPC: B01J27/188
Filed: 1999-11-16
Abstract: The present invention includes a catalyst having (a) a non-metallic support having a plurality of pores; (b) a metal heteropoly acid salt that is insoluble in a polar solvent on the non-metallic support; wherein at least a  portion of the metal heteropoly acid salt is dispersed within said plurality  of pores. The present invention also includes a method of depositing a metal  heteropoly acid salt that is insoluble in a polar solvent onto a non-metalli c support having a plurality of pores. The method has the steps of: (a) obtaining a first solution containing a first precursor of a metal salt cation; (b) obtaining a second solution containing a second precursor of a heteropoly acid anion in a solvent having a limited dissolution potential fo r said first precursor; (c) impregnating the non-metallic support with the fir st precursor forming a first precursor deposit within the plurality of pores, forming a first precursor impregnated support; (d) heating said first precursor impregnated support forming a bonded first precursor impregnated support; (e) impregnating the second precursor that reacts with the precurso r deposit and forms the metal heteropoly acid salt.
Patent CA-2349983-A1 (CA)
Title: Safety athletic pole
Inventor: BUJOLD EDWARD J
IPC: A63C11/22
Filed: 2001-06-05
Abstract: An athletic pole adapted for minimizing injuries to the hand and wrist of the user in the event of an accident. The pole includes a handle having an enlarged handle base, a shaft extending from the handle and including a proximal end adjacent the handle, a distal end, and an enlarged shaft base on the proximal end that normally engages the handle base.  The pole also includes an attachment device for attaching the handle to the shaft and a biasing device exerting sufficient tension on the attachment device for biasing the attachment device to maintain the handle base and the shaft base in a mating, coaxial position during normal use. The periphery of the handle base and the periphery of the shaft base collectively form a fulcrum point for permitting controlled, tensioned articulation of the handle relative to the shaft. Such articulation results when a predetermined bending force is applied to the pole that is sufficient to overcome the tension of the biasing device on the attachment device.
Patent CA-2350609-A1 (CA)
Title: N-substituted 2-cyanopyrrolidines
Inventor: VILLHAUER EDWIN BERNARD
IPC: A61K31/4015
Filed: 1999-12-09
Abstract: The present invention relates to a compound of formula (I), wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula (I) inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
Patent CA-2351365-A1 (CA)
Inventor: RHODES KENNETH
IPC: A61K45/00
Filed: 1999-11-19
Abstract: The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels a nd modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors ha ve been introduced, and nonhuman transgenic animals in which a PCIP gene has be en introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided .
Patent CA-2351389-A1 (CA)
Inventor: BEHAGEN MICHAEL
IPC: H04Q9/00
Filed: 1999-11-23
Abstract: L'invention concerne un dispositif qui permet de présenter à distance des données à partir du moniteur d'un ordinateur central et de télécommander entièrement l'ordinateur central. Le dispositif de l'invention inclut un dispositif d'affichage audiovisuel éloigné et une plate-forme d'entrée éloignée. La plate-forme d'entrée éloignée inclut un émetteur radio, et le dispositif d'affichage audiovisuel éloigné inclut un récepteur radio pour communiquer avec l'ordinateur central, lequel communique avec un émetteur radio correspondant et un récepteur radio correspondant. L'ordinateur central envoie, par l'émetteur radio, des signaux audio et vidéo pour commander la présentation des données, de préférence sous forme d'une interface utilisateur graphique (GUI), sur le dispositif d'affichage audiovisuel éloigné. De préférence, ces données incluent également des séquences vidéo et/ou des graphismes, ainsi que des séquences sonores. De même, l'ordinateur central reçoit, par le biais du récepteur radio, des instructions d'entrée émanant de l'utilisateur et passant par la plate-forme d'entrée éloignée. Seul l'ordinateur central est équipé d'une UCT, bien que le dispositif d'affichage audiovisuel éloigné et/ou la plate-forme d'entrée éloignée puisse(nt) inclure un microprocesseur ou autre processeur. Ainsi, les unités de l'ordinateur avec lesquelles l'utilisateur interagit directement, le dispositif d'affichage audiovisuel et la plate-forme d'entrée peuvent être constitués de dispositifs éloignés, éventuellement physiquement séparés de l'unité principale de l'ordinateur central (doté d'une UCT).
Patent CA-2355227-A1 (CA)
Title: Targeted gene transfer using g protein coupled receptors
Inventor: DOUGLASS JAMES G III
IPC: C12N15/861
Filed: 1999-12-22
Abstract: A method of delivering heterologous nucleic acid (e.g., a gene sequence) int o a cell comprises attaching a virus containing a heterologous gene sequence t o a G protein coupled receptor (i.e., a seven transmembrane receptor such as t he P2Y2 receptor). The virus may be attached to the receptor by means of a bridging antibody, or by binding an antibody specific for the receptor with an antibody specific for the virus, wherein the antibody that specifically bind s with the receptor and the antibody that specifically binds to the virus are cross-linked. Alternatively, the virus may express a peptide that specifical ly binds to the receptor. The receptor may be induced to internalize by means o f the addition of a ligand known to trigger internalization of the receptor in to the cell.
Patent CA-2356483-A1 (CA)
Inventor: CONNER JOE
IPC: G06Q10/10
Filed: 1999-12-15
Abstract: L'invention concerne un procédé permettant de trier un message d'information reçu, dans lequel la source d'émission du message est indiquée par un identificateur unique accompagnant le message, par exemple, dans le cadre d'un système de messagerie vocale ou électronique. Ledit procédé consiste à recevoir le message, à rechercher l'identificateur dans une base de données, à affecter un code au message en fonction du résultat de l'opération de recherche, et à utiliser ce code pour affecter le message d'une priorité ou à pour le transmettre.
Patent CA-2357891-A1 (CA)
Title: Method for manufacturing 2,6-dimethylnaphthalene
Inventor: YAMAMOTO KOJI
IPC: C07C7/14
Filed: 2001-09-28
Abstract: The present invention provides a method for manufacturing a highly pure 2,6-dimethylnaphthalene having a purity of 99% or more even when a mixture of dimethylnaphthalene isomers containing 5 wt% or more of 2,7-dimethylnaphthalate is used as a feedstock. The method for manufacturing 2,6-dimethylnaphthalene comprises a step of performing crystallization and solid-liquid separation of a liquid primarily containing dimethylnaphthalene isomers so that the liquid is separated into a cake containing the dimethylnaphthalene isomers and a mother liquor, and a step of performing separation/purification of the cake. In the method described above, the crystallization and the solid-liquid separation are performed under the condition in which the ratio of the content of 2,6-dimethylnaphthalene in the mother liquor to that of 2,7-dimethylnaphthalene therein is not less than 1 so that the content of 2,6-dimethylnaphthalene in the cake is 60% or more and that the content of 2,7-dimethylnaphthalene therein is 6.5% or less.     As a result, a highly pure 2,6-dimethylnaphthalene is obtained by performing the separation/purification of the cake.
Patent CA-2358006-A1 (CA)
Title: Method of fabricating compound semiconductor device
Inventor: ARAKAWA SATOSHI
IPC: B82Y10/00
Filed: 2001-09-20
Abstract: Disclosed is a method of fabricating a compound semiconductor device, which has an Al-based compound semiconductor layer and is suitable for producing, for example, a semiconductor laser device with a buried structure. The method comprises a first step of sequentially performing vapor growth of a plurality of compound semiconductor layers including an Al-based compound semiconductor layer formed on a semiconductor substrate by using a metalorganic chemical vapor deposition (MOCVD), thereby forming a semiconductor multilayer (epitaxial layer) having, for example, a double heterostructure; a second step of selectively etching a specific compound semiconductor layer in the semiconductor multilayer other than the Al-based compound semiconductor layer in the MOCVD using a bromine-based gas, thereby forming a mesa; and a third step of regrowing a predetermined compound semiconductor layer on the semiconductor multilayer in the MOCVD following the etching step.
Patent CA-2360804-A1 (CA)
Title: Water soluble package
Inventor: EDWARDS DAVID BRIAN
IPC: C11D17/04
Filed: 2000-02-29
Abstract: A water soluble package containing a fluid substance for release on dissolution of the package, the package having a dome shaped body portion fo r containing the fluid substance comprising a first sheet of a water soluble material thermoformed to form a body wall of the body portion, and a second sheet of water soluble material superposed on the first sheet and sealed thereto along a continuous region of the superposed sheets to form a base wa ll of the body portion.