Patent GB-900779-A (GB)
Title: Quinazolines
Inventor: BROWN JOSEPH PATRICK
IPC: A23B7/154
Filed: 1959-04-22
Abstract: Common soap, potassium soap, sodium salts of long-chain alkylated aromatic sulphonic acids, beeswax, carnauba wax, paraffin wax and wax polishes are admixed with a bacteriostat comprising a 2-guanidinoquinazoline of the formula:- <FORM:0900779/III/1> wherein R1, R2, R3 and R4 are each hydrogen, an alkyl group, an alkoxy group, an analkyl group, a hydroxyl group, a nitro group, an amino group or a (2-guanidinoquinazolinyl) methyl group, but where not more than three of R1, R2, R3 and R4 is a hydrogen atom, R5 is a hydrogen atom or an alkyl group and R6 is a hydrogen atom or an alkyl group, an analkyl group or an aromatic group, and organic or inorganic acid addition salts and quaternary salts thereof.ALSO:Vinyl polymers and copolymers, such as polystyrene, polyvinyl chloride and polyethylene, and phenol or melamine resins are preserved against fungal or bacterial attack by incorporation of from 0,05% to 5% by weight of a 2-guanidinoquinazoline of the formula:-  <FORM:0900779/IV(a)/1> wherein R1, R2, R3 and R4 are each hydrogen, an alkyl group, an alkoxy group, an aralkyl group, a hydroxyl group, a nitro group, an amino group or a (2-guanidinoquinazolinyl)-methyl group, but where not more than three of R1, R2, R3 and R4 is a hydrogen atom, R5 is a hydrogen atom or an alkyl group, and R6 is a hydrogen atom or an alkyl group, an aralkyl group, or an aromatic group, or an organic or inorganic acid addition salt or quaternary salt thereof.ALSO:The invention comprises (1) 2-guanidino-quinazolines of the formula:- <FORM:0900779/IV (b)/1> wherein R1, R2, R3 and R4 are each hydrogen, an alkyl group, an alkoxy group, an aralkyl group, a hydroxyl group, a nitro group, an amino group or a (2-guanidinoquinazolinyl) methyl group, but where not more than three of R1, R2, R3 and R4 is a hydrogen atom; R5 is a hydrogen atom or an alkyl group; R6 is a hydrogen atom, an alkyl group, an aralkyl group or an aromatic group; and salts of such compounds, e.g. with hydrohalic, acetic, nitric or sulphuric acid, and quaternary derivatives, e.g. with alkyl chlorides; and (2) the preparation of these and other 2-guanidinoquinazolines (including halogen-substituted derivatives) by reacting a salt of a 2,2-dialkyl-1,2-dihydro-quinoline with dicyandiamide or an N-substituted derivative thereof.  The compounds have bacteriostatic properties.ALSO:A bacteriostatic and fungicidal composition comprises a 2-guanidinoquinazoline of the formula <FORM:0900779/VI/1> wherein R1, R2, R3 and R4 are each hydrogen, an alkyl group, an alkoxy group, an aralkyl group, a hydroxyl group, a nitro group, an amino group or a (2-guanidinoquinazolinyl) methyl group, but where not more than three of R1, R2, R3 and R4 is a hydrogen atom, R5 is a hydrogen atom or an alkyl group, and R6 is a hydrogen atom or an alkyl group, an aralkyl group or an aromatic group, and organic or inorganic acid addition salts and quaternary salts thereof, together with an inert diluent.  The composition may be formulated as a lotion, paste, cream, ointment, powder or soap, and may be used for the protection of cloth, leather or agricultural products.