Patent SG-11201804373V-A (SG)
Title: Compositions and methods for immunooncology
Inventor: CHEN MING-WEI
IPC: C12N15/113
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization International Bureau (43) International Publication Date .... ..sr.) 8 June 2017 (08.06.2017) W I P0 1 PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/093969 Publication 1111111111111111111111111111111RIIIIIIIIIIIIIII Number Al (51) International Patent Classification: Biomedical Research, Inc., 250 Massachusetts Avenue, C12N 15/113 (2010.01) A61P 35/00 (2006.01) Cambridge, MA 02139 (US). A61K 35/17 (2015.01) C12N 15/09 (2006.01) (74) Common Representative: NOVARTIS AG; Lichtstrasse (21) International Application Number: 35, 4056 Basel (CH). PCT/IB2016/057318 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 2 December 2016 (02.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/263,169 4 December 2015 (04.12.2015) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/316,784 1 April 2016 (01.04.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 62/394,290 14 September 2016 (14.09.2016) US TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (71) Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, ZW. 4056 Basel (CH). INTELLIA THERAPEUTICS, INC. (84) Designated States (unless otherwise indicated, for every [US/US]; 40 Erie Street, Ste. 130, Cambridge, MA 02139 kind of regional protection available): ARIPO (BW, GH, (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: CHEN, Ming-Wei; c/o Novartis Institutes for TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139 DECK, Melissa; Intellia DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (US). c/o Therapeutics, Inc., 40 Erie Street, Ste. 130, Cambridge, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, MA 02139 (US). DRANOFF, Glenn; c/o Novartis Insti- GW, KM, ML, MR, NE, SN, TD, TG). tutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139 (US). MICKANIN, Declarations under Rule 4.17: Craig; c/o Novartis Institutes for Biomedical Research, as to applicant's entitlement to apply for and be a Inc., 250 Massachusetts Avenue, Cambridge, MA 02139 granted patent (Rule 4.170) (US). LESCARBEAU, Reynald; c/o Intellia Therapeutics, Inc., 40 Erie Street, Ste. 130, Cambridge, MA 02139 (US). Published: RICHARDSON, Celeste; c/o Novartis Institutes for Bio- - with international search report (Art 21(3)) medical Research, Inc., 250 Massachusetts Avenue, Cam- bridge, MA 02139 (US). STEWART, Morag; c/o Intellia — before the expiration of the time limit for amending the Therapeutics, Inc., 40 Erie Street, Ste. 130, Cambridge, claims and to be republished in the event of receipt of MA 02139 (US). YANG, Yi; c/o Novartis Institutes for amendments (Rule 48.2(h)) Il .4t Cr \ 0\ M 0\ 0 IN Il O N (54) Title: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY (57) : The present invention is directed to genome editing systems, reagents and methods for immunooncology.