Patent SG-11201908487Y-A (SG)
Title: Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast
Inventor: LISANTI MICHAEL
IPC: C07C235/46
Filed: 2018-03-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT ill~~~~~~~~ 011101010VIIIOH olo olomollm olo Homo iflo oimIE (10) International Publication Number WO 2018/170109 Al (51) International Patent Classification: C07C 235/46 (2006.01) C07C 275/24 (2006.01) (21) International Application Number: PCT/US2018/022403 (22) International Filing Date: 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,688 15 March 2017 (15.03.2017) US (71) Applicant: LUNELLA BIOTECH, INC. [CA/CA]; 145 Richmond Road, Ottawa, ON K1Z 1A1 (CA). (72) Inventors; and (71) Applicants: LISANTI, Michael, P. [US/US]; 8300 Greensboro Drive, Suite 1100, Tysons, PA 22102 (US). SOTGIA, Federica [US/US]; 8300 Greensboro Drive, Suite 1100, Tysons, VA 22102 (US). (74) Agent: BRADY, Joshua, B.; Williams Mullen, 8300 Greensboro Drive, Suite 1100, Tysons, VA 22102 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 1-1 O 1-1 O N 1-1 00 1-1 O N O (54) Title: MITORIBOSCINS: MITOCHONDRIAL-BASED THERAPEUTICS TARGETING CANCER CELLS, BACTERIA, AND PATHOGENIC YEAST (57) : The present disclosure relates to inhibitors of mitochondrial function. Methods of screening compounds for mitochon- drial inhibition are disclosed. Also described are methods of using mitochondrial inhibitors called mitoriboscins - mitochondrial-based therapeutic compounds having anti-cancer and antibiotic properties - to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitochondrial inhibitors to provide anti-aging benefits. Specific mitoriboscin compounds and groups of mitoriboscins are also disclosed.