Patent SG-11201809922Y-A (SG)
Title: Pyrazole derivatives as plasma kallikrein inhibitors
Inventor: DAVIE REBECCA LOUISE
IPC: C07D403/14
Filed: 2017-05-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MD 1101/110 111010101111101011111 0 0111111111111111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/207983 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: C07D 401/14 (2006.01) A61K 31/444 (2006.01) C07D 401/10 (2006.01) A61K 31/501 (2006.01) CO7D 403/06 (2006.01) A61K 31/506 (2006.01) CO7D 403/14 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61P 27/00 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (21) International Application Number: PCT/GB2017/051546 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (22) International Filing Date: 31 May 2017 (31.05.2017) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: 1609517.6 31 May 2016 (31.05.2016) GB 62/343,363 31 May 2016 (31.05.2016) US 1702044.7 08 February 2017 (08.02.2017) GB 62/456,219 08 February 2017 (08.02.2017) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — (71) Applicant: KALVISTA PHARMACEUTICALS LIMITED [GB/GB]; Building 227, Tetricus Science Park, Porton Down, Salisbury SP4 OJQ (GB). Published: — with international search report (Art. 21(3)) = — = (72) Inventors: DAVIE, Rebecca Louise; c/o KALVISTA PHARMACEUTICALS LIMITED, Building 227, Tetri- cus Science Park, Porton Down, Salisbury SP4 OJQ (GB). EDWARDS, Hannah Joy; c/o KALVISTA PHARMA- CEUTICALS LIMITED, Building 227, Tetricus Science Park, Porton Down, Salisbury SP4 OJQ (GB). EVANS, David Michael; c/o KALVISTA PHARMACEUTICALS LIMITED, Building 227, Tetricus Science Park, Porton = Down, Salisbury SP4 OJQ (GB). HODGSON, Simon = Teanby; Orchard House, The Avenue, Ampthill, Bed- fordshire MK45 2NR (GB). PETHEN, Stephen John; c/ o KALVISTA PHARMACEUTICALS LIMITED, Build- ing 227, Tetricus Science Park, Porton Down, Salisbury = = = SP4 OJQ (GB). ROOKER, David Philip; c/o KALVISTA _ PHARMACEUTICALS LIMITED, Building 227, Tetricus = Science Park, Porton Down, Salisbury SP4 OJQ (GB). = = (74) Agent: PHILLIPS, Gillian Margaret et al.; Carpmaels = & Ransford LLP, One Southampton Row, London WC1B — 5HA (GB). = (54) Title: PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS .4 (57) : The present invention provides a selection of com- cr) A R6 I pounds of formula (I): (I) compositions comprising such com- GO IN X yN z R5 pounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma 0 I kallikrein activity is implicated); and methods of treating patients ei YV H with such compounds; wherein R5,R6,R7, A, B,W, X, Y and Z N R7 are as defined herein. N \—B 0 (I) C