baber/WOPTO huggingface dataset:
Patent AT-E321854-T1 (AT)
Inventor: MELMED SHLOMO
IPC: A01K67/027
Filed: 1997-11-21
Granted: 2006-04-15
Abstract: Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTTG), and nucleic acids encode them. Examples are the human and rat PTTG proteins. The nucleic acids may be applied to the production of a recombinant protein, and to the detection of the presence of PTTG genes in different species. The nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences and/or being carried by a host cell. The nucleic acids may also be delivered to a mammal to compensate for the absence, or a defective expression, of endogenous protein. The nucleic acids, proteins, and antibodies are also employed in disgnostic assays, as well as, for example, in the production of anti-PTTG antibodies (protein), therapeutic compositions and other applications of the proteins and antibodies. Various kits utilize nucleic acids, polypeptides, and/or antibodies. A transgenic non-human mammal expresses PTTG.
Patent AT-E313787-T1 (AT)
Inventor: JUVINALL JOHN W
IPC: G01B11/30
Filed: 1998-05-13
Granted: 2006-01-15
Abstract: Apparatus for inspecting the sealing surface area (36) of a container finish (34) that includes a structured light source (44) positioned to direct a collimated line-shaped light beam (46) onto the sealing surface area of a container as the container is moved relative to the light source. The line-shaped light beam at the container sealing surface area has a long dimension orthogonal to the container axis that extends chordally across the sealing surface area, and a narrow dimension tangential to the container axis. A light sensor (52) is disposed to receive portions of the line-shaped light beam reflected from the sealing surface area, and provides an electrical output signal that varies with height or level of the sealing surface with respect to the light source and sensor. The sensor is coupled to associated electronics (60) for providing information indicative of sealing surface height. The elongated dimension of the line-shaped light beam at the container sealing surface area accommodates wobble or misalignment at the sealing surface with respect to the light source and sensor. Furthermore, the elongated radial dimension of the line-shaped light beam at the container sealing surface area produces a reflection on the sensor from any wire-edge or over-press within the container mouth, thus producing at the sensor information indicative of both existence and height of any such wire-edge or over-press.
Patent AT-E232504-T1 (AT)
Inventor: ZAMBELLI MICHAEL P
IPC: B66B3/02
Filed: 1998-06-02
Granted: 2003-02-15
Abstract: The indicator (4) comprises an 'up' arrow (10) and a 'down' arrow (11) which light up when the cabin reaches a floor. The indicator is positioned on the door frame (3) of the door to the floor, and covers the vertical edge (13) of the door frame. The indicator is fixed to a mounting frame forming the door frame together with the base frame. The directional arrows of the indicator with one cover (12) per arrow are positioned on a front (14) and inner (15) side of the door frame.
Patent AT-E258711-T1 (AT)
Inventor: DOHNAL DIETER
IPC: H01F29/04
Filed: 1998-09-01
Granted: 2004-02-15
Abstract: The multi-contact switch includes a by-pass switch that has a pair of movable contacts (2.1.2.2) mounted on a carrier (2). The carrier is indexed by a drive unit and the movable contacts selectively engage fixed contacts (3.1,3.2). The carrier is mechanically coupled to the drive spindle of a three phase stage switching arrangement.
Patent AT-E262977-T1 (AT)
Inventor: LAUTENSCHLAGER WERNER
IPC: B01J19/00
Filed: 1998-11-09
Granted: 2004-04-15
Abstract: A system and method for controlling a microwave heated chemical process is disclosed. Time varying concentrations of some chemical substances within fumes in the microwave oven are monitored to detect concentration variations for which responses are known. Responses to the detected variations are initiated to control the chemical process without terminating the process. Examples of responses include varying microwave radiation energy, initiating safety systems (f.e. neutralizing sensed chemicals, flooding the chamber with a neutralizing substance etc.), increased venting of the microwave oven, and so forth.
Patent AT-E260696-T1 (AT)
Inventor: MALEIKA HUBERTUS
IPC: A63H18/02
Filed: 1998-11-18
Granted: 2004-03-15
Abstract: A central barrier (7) is present between two adjacent lanes in at least the curved track sections. Toy racing cars (4) are driven along two or more lanes (1, 2) on a race track with straight and curved sections (3) via parallel contact rails (13-20), which supply electricity needed to drive and steer the cars. Barriers (5, 6) are present on either side of the track.
Patent AT-E248384-T1 (AT)
Inventor: LOCATELLI DANIEL JOSEPH
IPC: G02C9/00
Filed: 1998-02-20
Granted: 2003-09-15
Abstract: The present hook is a deformable hook for removably securing a monocular screen to an eyeglass. The hook includes a first end portion for fixing to said screen, a second end portion for contacting with a peripheral surface of said eyeglass, and a central portion interconnecting the first and second end portions and for passing over an edge surface of the eyeglass. The first and second end portions include a pin portion extendable through an orifice in a periphery of the screen. The hook is a solid body, and the first end portion is preferably of a rectilinear shape extending along a longitudinal axis.
Patent AT-E228473-T1 (AT)
Inventor: EBERLE JUERG
IPC: B65H29/66
Filed: 1999-07-20
Granted: 2002-12-15
Abstract: The conveyor system has a belt (10) to take the flow of loose and limp products (12) in an overlapping configuration (S) from the transport system (14), for onwards movement. The conveyor belt (10) passes round a deflection drum (16), to form an advancement movement gap (26) between them to take the overlapping product structure (S), with an edge section over the drum on one side. The recirculating path (104) of the transport system (14) runs next to the drum, fitted with grips (20) to grasp the overlapped (S) materials at the edges for onwards movement.
Patent AT-E270718-T1 (AT)
Inventor: FUJITA AKITSUGU
IPC: C22C37/08
Filed: 1998-07-10
Granted: 2004-07-15
Abstract: Heat resisting cast steel contains (wt.%) carbon (0.07-0.15), silicon (0.05-0.3), manganese (0.1-1) chromium (8-10), nickel (0.01-1), vanadium (0.1-0.3), niobium and tantalum (0.01 to 0.2), molybdenum (0.1-0.7), tungsten (1-2.5), cobalt (0.1-5), and nitrogen (0.03 to 0.07), and hafnium and/or neodymium (0.001-0.2), and balance being iron and incidental impurities.
Patent AT-E211002-T1 (AT)
Inventor: BROWN COLIN
IPC: A61L31/00
Filed: 1999-05-13
Granted: 2002-01-15
Abstract: A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccharide dextrin.
Patent AT-E520122-T1 (AT)
Inventor: MORII TOSHIYUKI
IPC: H03M7/30
Filed: 1999-06-08
Granted: 2011-08-15
Abstract: First codebook 61 and second codebook 62 respectively have two subcodebooks, and in respective codebooks, addition sections 66 and 67 obtain respective excitation vectors by adding sub-excitation vectors fetched from respective two subcodebooks. Addition section 68 obtains an excitation sample by adding those excitation vectors. According to the aforementioned constitution, it is possible to store sub-excitation vectors with different characteristics in respective sub-codebooks. Therefore, it is possible to correspond to input signals with various characteristics, and achieve excellent sound qualities at the time of decoding.
Patent AT-E254169-T1 (AT)
Inventor: ROBERTS NEIL
IPC: G01N31/22
Filed: 1999-08-16
Granted: 2003-11-15
Abstract: The invention relates to a process for measuring the enzymatic activity of a solid feed sample wherein the process includes contacting the solid feed sample, a reagent for the enzyme whose activity it is desired to measure comprising a substrate specific for the enzyme linked to a chromophore, and a buffer for dissolving the enzyme, in a container fitted with a leak proof opening and closing system; shaking the container to distribute the chromophore in the liquid buffer; and then observing the coloration of the liquid phase, the coloration being proportional to the activity of the enzyme present in the sample.
Patent AT-E252797-T1 (AT)
Inventor: RADIMIRSCH MARKUS
IPC: H04L12/403
Filed: 1999-08-27
Granted: 2003-11-15
Abstract: In a device for data transmission having a central station and a plurality of subscribers, in addition to useful signal data phases, signaling data phases are provided for the downlink and uplink in a transmission frame ( 3 ). The signaling data phases for the downlink are divided into signaling data phases related to the central station and related to the protocol. The positions of these two signaling data phases are identified directly or indirectly by identifiers.
Patent AT-E325425-T1 (AT)
Inventor: TRESKY MIROSLAV
IPC: H01L21/683
Filed: 1999-12-21
Granted: 2006-06-15
Abstract: The invention relates to a hand tool (1) for the assembly of small, notably electronic, components. Said hand tool comprises a shaft (10) fitted with a handle (11) as well as a head part (12). In the head part (12) a spindle is mounted which houses a vacuum tool (13) and can be adjusted by means of a finger-actuated turning knob (40). The axis (C) of the spindle or vacuum tool is positioned at a constant angle to the shaft axis (B). The turning knob axis is arranged at a distance from the spindle or vacuum tool axis (C) and offset in the direction of the handle (11). A driving connection is provided for between the turning knob (40) and the spindle. The hand tool (1) can be used comfortably and reliably and prevents the fingers holding on to the handle (11) from creating an obstacle which blocks the user's view of the component or object, thus also avoiding potential damage to the parts to be manipulated with the tool.
Patent AT-E282304-T1 (AT)
Inventor: BABO TIVADAR
IPC: A01G17/02
Filed: 1999-12-14
Granted: 2004-12-15
Abstract: Agrotechnical method for Branch Cordon trained vine, for the mechanizable control of its growth, and yield; where in the branch cordon plantation a cordon arm supporting wire parallel with the direction of the stock row, preferably in 160-190 cm height is used; long canes are preferably cultivated every 10-30-40 cm from one another into producing twigs; characterised in that sprouting, yield and quality are regulated by the thinning of the main buds in the upper zone of the foliage wall, and the measure of thinning of the main buds thus producing twigs are cultivated having short shoots and short canes (which require no pruning), which appropriately reach near the ground, have off-shoots and sometimes grow higher than the cordon arm.
Patent AT-E506049-T1 (AT)
Inventor: BACHMAN TIMOTHY
IPC: A61C17/00
Filed: 1999-12-16
Granted: 2011-05-15
Abstract: A housing (20) for an oral irrigator having a hand piece (26) includes a base unit (22) having an upper, a lower portion (32, 30), the lower portion engaged with a support surface having an upper surface defining a recess (38) for receiving the hand piece, and the lower portion defining a peripheral shoulder (56). The upper portion extends upwardly from the lower portion, defines a top surface (62), the top surface defining a port and a key structure (66); the upper portion being positioned inside the peripheral shoulder. A receiver (24) is positionable on the base unit in a first configuration and in a second configuration.
Patent AT-E227671-T1 (AT)
Inventor: CARGILE DAVID W
IPC: B65D1/42
Filed: 1999-12-15
Granted: 2002-11-15
Abstract: A blow-molded plastic container (10) providing enhanced top loading capability. The container (10) has an inner peripheral surface (24) on which a plurality of integral, solid, inwardly and longitudinally extending ribs (26) are formed. Preferably, the ribs (26) extend throughout the entire container inner surface (24) from the top edge of the finish (20) to a mold parting line (28) on the base (14). A method and apparatus for making the container (10) is also disclosed.
Patent AT-E344028-T1 (AT)
Inventor: TIDWELL RICHARD R
IPC: C07D235/20
Filed: 1999-09-15
Granted: 2006-11-15
Abstract: Methods of treating fungal infections comprise administering a therapeutically effective amount of a compound described by Formulas [(I)-(VI)]. Examples of fungal infections include Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Fusarium solani, and combinations thereof.
Patent AT-E314371-T1 (AT)
Inventor: GAO YING-DUO
IPC: A61K31/403
Filed: 1999-11-08
Granted: 2006-01-15
Abstract: Compounds of general structural formula Iare selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
Patent AT-E228351-T1 (AT)
Inventor: SPOHR REIMAR
IPC: A61K9/00
Filed: 1999-10-27
Granted: 2002-12-15
Abstract: Disclosed is a method for regulating a chemical valve consisting of a porous matrix and of a gel layer which can swell due to the ambient temperature thereof. In a preferred embodiment, said matrix is configured as a microporous membrane whose individual pore or pores is/are produced by etching particle traces, e.g. of heavy ions in said matrix. In the preferred embodiment, the matrix consists of or is lined with a material, whereby said gel layer which can swell can be produced on the surface of said material. The matrix comprising the pore/s is inserted into an electrolyte. A voltage differential in the form of an electric AC or DC current to the electro-thermal or electro-osmotic control of said pore/s is applied to both sides of said pore/s via the two electrolyte areas, whereby the two electrolyte areas of both sides of said matrix are separated from one another and are electrically insulated from one another.
Patent DE-07751573-T1 (DE)
Title: Flüssigkeitssteuerstrahl bei teillastbetrieb in einer hydraulischen turbine
Inventor: CIOCAN GABRIEL
IPC: F03B11/00
Filed: 2007-02-23
Abstract: Wasserturbine, die folgendes aufweist:  – einen Durchgang, der den Durchlauf von Flüssigkeit durch die Turbine hindurch ermöglicht,  – ein einen Bereich des Durchgangs definierendes Saugrohr, durch das Flüssigkeit während optimalen Turbinenbetriebsbedingungen normalerweise in einem Wirbelströmungsweg strömt,  – einen drehbaren Läufer, der stromaufwärts des Saugrohrs angebracht ist und sich um eine Mittelachse herum dreht, die durch den Läufer hindurch verläuft und sich in das Saugrohr hinein erstreckt,  – zumindest eine Düsenkopfeinrichtung, die relativ zu der Mittelachse des Läufers und angrenzend an einen oberen Bereich des Saugrohrs positioniert ist, wobei die zumindest eine Düsenkopfeinrichtung zumindest eine Düse hat, aus welcher während eines Teillast-Turbinenbetriebs ein entsprechender Hochgeschwindigkeits-Flüssigkeits-Steuerstrahl axial stromabwärts des Läufers und in Flüssigkeit hinein eingespritzt wird, die in den oberen Bereich des Saugrohrs hineinströmt, um so ein Zusammenbrechen des Wirbelströmungsweges abzuschwächen.
Patent DE-238384-T1 (DE)
IPC: B65D71/00
Filed: 1987-02-27
Abstract: This one-piece packaging is made from a blank of foldable material and includes a top wall whose width is less than the width of the bottom wall, and is not greater than half the maximum transverse dimension of the articles. This width may, in the limit, be zero. As a result: at least a portion of the height of the front wall is sloping; the windows cut out in the front wall which have bottom portions that are narrower than the maximum transverse dimension of the bottom regions of the articles in order to retain the articles in the packaging also have top portions whose width is equal to the maximum transverse dimension of the top regions of the articles so that said top regions of the articles project as much as possible from said packaging; and the side end faces of the packaging which are optionally closed by walls are at least partially trapezoidal, and in said limit are at least partially triangular when said top wall is of zero width.
Patent ES-2293872-T1 (ES)
Inventor: RIVAL REMY
IPC: F24F7/08
Filed: 2006-08-09
Abstract: The system, designed to prevent cold air from lingering between cold storage/display units along opposite sides of an aisle (E), consists of one duct (3) extending from the top (5) to the lower front edge of a unit (1) on one side of the aisle and a second duct (4) from the lower front edge (8) of an opposite unit (2) to its upper surface (7), drawn by an extractor fan (14). The ducts can be formed by the gaps between two units set back-to-back or between the back of one unit and an adjacent wall, with the air flow controlled by temperature sensors in the ducts.
Patent ES-2035809-T1 (ES)
Title: Tensor de cinturon en un sistema de cinturones de seguridad para vehiculos.
IPC: B60R22/18
Filed: 1992-03-10
Abstract: TENSOR DE CINTURONES EN UN SISTEMA DE CINTURONES DE SEGURIDAD PARA VEHICULOS. EL TENSOR DE CINTURONES (12) EN UN SISTEMA DE CINTURONES DE SEGURIDAD PARA VEHICULOS ESTA EQUIPADO CON UN ACCIONAMIENTO LINEAL DE EMBOLO/CILINDRO (18) ACTIVABLE MEDIANTE UN GENERADOR DE GAS PIROTECNICO, QUE ESTA DISPUESTO EN UNA CAJA DE APOYO (33) ENTRE UNA POSICION DE REPOSO Y UNA POSICION DE ACTIVACION DE FORMA BASCULABLE. EL ACCIONAMIENTO LINEAL DE EMBOLO/CILINDRO (18) FORMA UNA MASA DE INERCIA SENSIBLE AL VEHICULO QUE SE CARGA MEDIANTE TENSION PREVIA DE LOS RESORTES EN DIRECCION DE LA POSICION DE REPOSO Y QUE POR FUERZAS DE INERCIA CONDICIONADAS POR RETARDO SE PUEDE MOVER A LA POSICION DE ACTIVACION. EL GENERADOR DE GAS ESTA PROVISTO DE UN DETONADOR. EN LA CAJA DE APOYO (32) HAY ALOJADA UNA PIEZA DE PERCUSION CARGADA POR MUELLE QUE PRESENTA UN PERCUTOR PARA GOLPEAR SOBRE EL DETONADOR Y QUE SE MANTIENE EN UNA POSICION DE RESERVA MEDIANTE SU APOYO SOBRE UNA SUPERFICIE DE RETENCION DEL ACCIONAMIENTO LINEAL DEL EMBOLO/CILINDRO (18).
Patent ES-2038109-T1 (ES)
IPC: G01N33/533
Filed: 1989-07-24
Abstract: A 1,2-dioxetane of the formulaand an alkene of the formulaare described. The 1,2-dioxetane is useful in immunoassays and in DNA probes used for various purposes.
Patent ES-2109900-T1 (ES)
Title: Asiento de vehiculo.
Inventor: FOHL ARTUR
IPC: B60N2/48
Filed: 1997-01-20
Abstract: UN ASIENTO DE VEHICULO CON UN APOYO (5) DE CABEZA INTEGRADO EN EL RESPALDO (3) SE CARACTERIZA DE TAL MODO, QUE EL RESPALDO (3) ESTA PROVISTO CON UN EQUIPO DE RECEPCION DE FUERZA, CON UN EQUIPO DE TRANSMISION DE FUERZA Y UN EQUIPO DE AJUSTE DEL APOYO DEL CABEZAL. ESTOS EQUIPOS SE CONFIGURAN DE TAL MODO, QUE LA FUERZA GENERADA MEDIANTE LA MASA SOPORTADA DE UN OCUPANTE (1) DE VEHICULO EN CASO DE IMPACTO POSTERIOR SE RECEPCIONA PARCIALMENTE A TRAVES DEL EQUIPO DE RECEPCION DE FUERZA Y SE DIVIDE A TRAVES DEL EQUIPO DE TRANSMISION DE FUERZA HACIA EL EQUIPO DE AJUSTE, A FIN DE AJUSTAR HACIA ADENTRO EL APOYO (5) PARA LA CABEZA DEL OCUPANTE (1) DEL VEHICULO (1). EL APOYO (5) DE CABEZA PUEDE FORMAR UNA PALANCA (9) DE DOS BRAZOS CON UNA PARTE (5) DE RESPALDO QUE ACTUA COMO EQUIPO DE RECEPCION DE FUERZA, QUE ESTA APOYADO DE FORMA OSCILANTE ALREDEDOR DE UN EJE DE OSCILACION HORIZONTAL, DISPUESTO EN EL RESPALDO (3).
Patent CY-1108463-T1 (CY)
Title: Παρασιτοκτονος συνθεση η οποια περιλαμβανει ενα γαλακτικο εστερα ως παρεμποδιστη της κρυσταλλικης αναπτυξης
Inventor: SASSON YOEL
IPC: A01N43/653
Filed: 2008-10-29
Abstract: Η παρούσα εφεύρεση είναι μια μέθοδος για την παρεμπόδιση της κρυστάλλωσης των παρασιτοκτόνων συνθέσεων κατά τη διάρκεια της εφαρμογής τους, με την προσθήκη ενός γαλακτικού εστέρα σαν παράγοντα που παρεμποδίζει της κρυστάλλωση.
Patent CY-1109039-T1 (CY)
Inventor: GIOVANETTI ROBERTO
IPC: C07C229/28
Filed: 2009-04-30
Abstract: The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
Patent CY-1109751-T1 (CY)
Inventor: RIXON MARK W
IPC: A61K39/395
Filed: 2010-01-27
Abstract: Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.
Patent CY-1118570-T1 (CY)
Title: Νεα συνθεση αλφαιντανυλης για την αγωγη του οξεος πονου
Inventor: PETTERSSON ANDERS
IPC: A61K31/454
Filed: 2017-01-31
Abstract: Παρέχονται φαρμακευτικές συνθέσεις για την αγωγή του πόνου λ.χ. βραχυπρόθεσμου πόνου, οι οποίες συνθέσεις περιλαμβάνουν ένα μείγμα που περιλαμβάνει: (a) μικροσωματίδια αλφαιντανύλης, ή ενός φαρμακευτικά αποδεκτού άλατος αυτής, τα οποία μικροσωματίδια παρουσιάζονται επί των επιφανειών μεγαλύτερων σωματιδίων-φορέων• (b) μία υδατοδιαλυτή ασθενή βάση• και (c) μία ένωση η οποία είναι ένα ασθενές οξύ, το οποίο οξύ παρουσιάζεται σε στενή ανάμειξη με τα μικροσωματίδια αλφαιντανύλης ή άλατος αυτής. Η σύνθεση μπορεί περαιτέρω να περιλαμβάνει ένα μέσο καταθρυμματισμού. Το οξύ είναι κατά προτίμηση κιτρικό οξύ.
Patent CY-1118603-T1 (CY)
Title: Δοτες νιτροξυλιου για τη θεραπευτικη αγωγη πνευμονικης υπερτασης
Inventor: KALISH VINCENT J
IPC: A61P9/12
Filed: 2017-02-07
Abstract: Η εφεύρεση αφορά μεθόδους θεραπευτικής αγωγής, πρόληψης ή καθυστέρησης της εμφάνισης ή εξέλιξης πνευμονικής υπέρτασης χρησιμοποιώντας δότες υδροξυλίου ή φαρμακευτικώς αποδεκτά άλατα αυτών. Η εφεύρεση περαιτέρω αφορά μεθόδους ελάττωσης της μέσης πνευμονικής αρτηριακής πίεσης χρησιμοποιώντας δότες υδροξυλίου ή φαρμακευτικώς αποδεκτά άλατα αυτών.
Patent CY-1122724-T1 (CY)
Title: Ρυθμιση της δραστικοτητας των προνευροτροφινων
Inventor: NYKJAER ANDERS
IPC: C07K16/28
Filed: 2020-03-09
Abstract: Η παρούσα εφεύρεση παρέχει παράγοντες για την αναστολή της δεσμεύσεως μίας προ-νευροτροφίνης σε έναν υποδοχέα πεδίου Vps10p συγκεκριμένα της δεσμεύσεως ενός προ-ΝGF ή ενός προ-ΒDNF σε έναν υποδοχέα σορτιλίνης. Η εφεύρεση κατά συνέπεια παρέχει παράγοντες για την κατασκευή ενός φαρμάκου, για την αγωγή και/ή την πρόληψη νόσου ή διαταραχών όπως, αλλά όχι περιοριστικά, νευρολογικών, νευροψυχιατρικών και οφθαλμικών νόσων, διαταραχών και εκφυλίσεως καθώς επίσης και της παχυσαρκίας, του διαβήτη, του άλγους και/ή της αλγαισθησίας σε ένα άτομο.
Patent CY-1123093-T1 (CY)
Title: Φαρμακοφορο για την επαγωγη του trail
Inventor: JANDA KIM D
IPC: A61K31/519
Filed: 2020-03-20
Abstract: Γνωστοποιούνται ενώσεις ιμιδαζολινοπυριμιδινόνης οι οποίες έχουν δράση για να επάγουν την έκφραση των γονιδίων TRAIL σε μακροφάγα. Γνωστοποιείται περαιτέρω μια μέθοδος για την αγωγή διαφόρων καρκίνων η οποία περιλαμβάνει τη χορήγηση δραστικών ποσοτήτων μιας ιμιδαζολινοπυριμιδινόνης που έχει τη δομή του τύπου Ι στο παρόν. Η εφεύρεση προσανατολίζεται, σε διάφορες υλοποιήσεις, σε μια ένωση και μια φαρμακευτική σύνθεση που περιλαμβάνουν μια δραστική ποσότητα μιας ένωσης η οποία έχει τη δυνατότητα να επάγει την έκφραση του γονιδίου TRAILσε κύτταρα τα οποία έχουν τη δυνατότητα να εκφράζουν το γονίδιο TRAIL για να παραχθεί το TRAIL κυτοκίνης.
Patent CY-1122837-T1 (CY)
Title: Θεραπεια της γυροειδους αλωπεκιας
Inventor: SIERRA MICHAEL
IPC: A61K9/06
Filed: 2020-03-20
Abstract: Η παρούσα ευρεσιτεχνία παρέχει μια νέα θεραπευτική αγωγή της γυροειδούς αλωπεκίας. Το πρόβλημα που πρέπει να επιλυθεί με την εφεύρεση είναι η παροχή μιας νέας φαρμακευτικής χρήσης του 3-[(3S, 4R)-3-μεθυλ-6-(7Η-πυρρολο[2,3-d] πυριμιδιν-4-υλ)-1,6-διαζασπειρο[3.4]οκταν-1-υλ]-3-οξοπροπανιτριλίου. Ένας θεραπευτικός ή προληπτικός παράγοντας για τη γυροειδή αλωπεκία που περιέχει 3-[(3S, 4R)-3-μεθυλ-6-(7Η-πυρρολο[2,3-d]πυριμιδιν-4-υλ)-1,6-διαζασπειρο-[3.4]οκταν-1-υλ]-3-οξοπροπανονιτρίλιο ως δραστικό συστατικό.