baber/WOPTO huggingface dataset:
Patent PL-1664278-T3 (PL)
Title: Methods for producing recombinant proteins
Inventor: GLOVER DAVID JOHN
IPC: C07K16/00
Filed: 2004-09-02
Abstract: The present invention provides a method for controlling the partitioning of a recombinant protein between the supernatant and the periplasm in E. coli host cell cultures wherein expression of the recombinant protein by said cells is under the control of an inducible system, which method comprises: a) providing an E. coli host cell culture b) changing the growth rate of the E. coli host cells c) inducing expression of the recombinant protein wherein steps (b) and (c) can be performed in any order or simultaneously; and subsequently d) determining the yield of recombinant protein in the culture supernatant and the E. coli host cell periplasm e) comparing the yield determined in step (d) with the yield determined when at least one other growth rate has been used in step (b) f) selecting a growth rate from the comparison made in step (e) in which the partitioning of the recombinant protein between the supernatant and the periplasm is most suited to the primary recovery of the recombinant protein.
Patent PL-1736065-T3 (PL)
Title: An aerosol electronic cigarette
Inventor: HON LIK
IPC: A24F40/05
Filed: 2005-03-18
Abstract: The present invention relates to an electronic atomization cigarette which only contains nicotine without harmful tar. The electronic atomization cigarette includes a shell and a mouthpiece. The external wall of the shell has an air inlet. An electronic circuit board, a normal pressure cavity, a sensor, a vapor-liquid separator, an atomizer, a liquid-supplying bottle are sequentially provided within the shell, wherein the electronic circuit board comprises an electronic switching circuit and a high frequency generator. A stream passage of the sensor is provided on one side of the sensor, and a negative pressure cavity is provided in the sensor. The atomizer and the liquid-supplying bottle is in contact with each other. An atomization cavity is arranged in the atomizer. A retaining ring for locking the liquid-supplying bottle is provided between one side of the liquid-supplying bottle and the shell, and an aerosol passage is provided on the other side of the liquid-supplying bottle. The air inlet, normal pressure cavity, vapor-liquid separator, atomizer, aerosol passage, gas vent and mouthpiece are sequentially interconnected. The advantages of the present invention include smoking without tar, significantly reducing the cancerogenic risk, Furthermore, users still feel as if they are smoking and experiencing the same excitement, and the cigarette is no need to be lit and is no fire risk.
Patent PL-1852230-T3 (PL)
Title: Carcass press
Inventor: TÖNNIGS BODO
IPC: B27M3/18
Filed: 2006-05-03
Abstract: The clamp has a lower compression beam (1`) provided on a base frame (1), and two supports (2, 3) provided on the base frame, where one support is traversable horizontally on the base frame. Two pairs of horizontal compression beams (6, 7) are provided on the supports so as to be vertically traversable, and an upper compression beam (4) is placed on the supports so as to be vertically traversable. The supports are supported exclusively on the base frame in a vertical direction and are free at opposing ends (2`, 3`).
Patent PL-1879895-T3 (PL)
Title: Enzyme inhibitors
Inventor: DAVIDSON ALAN HORNSBY
IPC: C07D209/42
Filed: 2006-05-04
Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:   
Wherein  R 1   is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group;  R 2   is the side chain of a natural or non-natural alpha amino acid;  Y  is a bond, -C(=O)-, -S(=O) 2 -, -C(=O)O-, -C(=O)NR 3 -, -C(=S)-NR 3 , -C(=NH)NR 3  or -S(=O) 2 NR 3 - wherein R 3  is hydrogen or optionally substituted C 1 -C 6  alkyl;  L 1   is a divalent radical of formula -(Alk 1 ) m (Q) n (Alk 2 )p- wherein  m, n  and  p  are independently 0 or 1,  Q  is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5 - 13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula -X 2 -Q 1 - or -Q 1 -X 2 - wherein X 2  is -O-, S- or NR A - wherein R A  is hydrogen or optionally substituted C 1 -C 3  alkyl, and Q 1  is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5 - 13 ring members,  Alk 1   and  Alk 2   independently represent optionally substituted divalent C 3 -C 7 , cycloalkyl radicals, or optionally substituted straight or branched, C 1 -C 6  alkylene, C 2 -C 6  alkenylene ,or C 2 -C 6  alkynylene radicals which may optionally contain or terminate in an ether (-O-), thioether (-S-) or amino (-NR A -) link wherein R A  is hydrogen or optionally substituted C 1 -C 3  alkyl;  X 1   represents a bond; -C(=O); or - S(=O) 2 -; -NR 4 C(=O)-, -C(=O)NR 4 -,-NR 4 C(=O)NR 5 -, -NR 4 S(=O) 2 -, or -S(=O) 2 NR 4 - wherein R 4  and R 5  are independently hydrogen or optionally substituted C 1 -C 6  alkyl;  z  is 0 or 1;  A  represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system wherein the radicals R 1 R 2 NH-Y-L 1 -X 1 -[CH 2 ] z - and HONHCO-[LINKER]- are attached different ring atoms; and  -[Linker]-  represents a divalent radical of formula -(CH 2 ) x - L 3 -Ar 1 -L 4 - wherein x is 0 or 1; L 3  is Z or L 2  or Z-L 2  wherein Z is a bond, -NR 3 -, -NR 3 C(=O)-, -C(=O)NR 3 -,-NR 4 C(=O)-NR 3 -, -C(=S)-NR 3 , -C(=N)-NR 3  -NR 3 S(=O) 2 -, or -S(=O) 2 NR 3 - wherein R 3  is hydrogen or C 1 -C 6  alkyl; - C(=O); or -S(=O) 2 -; and L 2  is a bond or an optionally substituted divalent C 1 -C 3  alkylene radical; Ar 1  is a divalent phenyl radical or a divalent mono-, or bi-cyclic heteroaryl radical having 5 to 13 ring members; and L 4  is a bond or optionally substituted -CH 2 - or -CH=CH-.
Patent PL-1968509-T3 (PL)
Title: Determining optimal positioning of ophthalmic devices by use of image processing and autofocusing techniques
Inventor: CAMPIN JOHN A
IPC: A61F9/01
Filed: 2006-12-21
Abstract: A system or method of positioning an ophthalmic device relative to an eye is provided. The method first obtains a series of images of an eye. In these series of images, the distance between the ophthalmic device and the eye is varied while the region of the eye image remains substantially the same. It is possible then to process these images to determine the high frequency content associated with each image. By comparing the high frequency content associated with each image, it is possible to determine which image has the largest amount of high frequency content. The high frequency content is maximized when the image is the sharpest. An optimally focused image will have the largest amount of high frequency content. By examining the high frequency content associate with the series of images is impossible to adjust the relative position and distance between the eye and the ophthalmic device to the distance associated with the image having the largest amount of high frequency content (i.e., optimally focused).
Patent PL-1907638-T3 (PL)
Title: Method for manufacturing cagelss lavatory dispensing divices
Inventor: LU ROBERT ZHONG
IPC: E03D9/02
Filed: 2007-06-14
Abstract: The present invention relates to a method for the manufacture of a lavatory dispensing device useful for the delivery of at least one treatment composition, preferably a cleaning composition and/or a sanitizing composition to a sanitary appliance.
Patent PL-2078665-T3 (PL)
Title: Frame construction for an omnibus
Inventor: ÜBELACKER ANDREAS
IPC: B62D33/04
Filed: 2008-11-29
Abstract: The construction has an armed node (4) provided with arm ends (5a-5f), and a metal profile element (1) fastened at the arm ends, where the arm ends are arranged in a common plane. A profile of the arm ends corresponds to a profile of the element. A connector is arranged between the arm ends and the element. An end (13) of the element, which is welded at the arm ends, is inserted over an end of the arm ends. A connector consists of a plug pin in the arm ends and in the element. A circle-arc-shaped transition (15) is arranged between the arm ends.
Patent PL-2109474-T3 (PL)
Title: Injection button
Inventor: STROEM HANSEN TORBEN
IPC: A61M5/315
Filed: 2008-01-21
Abstract: A push button connection for an injection device comprising a push button (10) and a driving part (20). The two parts of the push button connection are mounted to each other and is relatively rotatable to each other. In order to minimize the friction occurring between the push button and the driving part when relatively rotated forces are transmitted via a pivot bearing (18, 22). In order also to minimize the effect of forces appearing dislocated from the center line a number of radial bearings (13, 23; 14, 25) having a little friction diameter is provided.
Patent GR-3001226-T3 (GR)
Title: Single-component tissue adhesive and method for producing same
Inventor: HEIMBURGER NORBERT PROF DR
IPC: A61K38/43
Filed: 1990-12-21
Abstract: 1. Claims for the Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A tissue adhesive containing, in liquid or solid form, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors and calcium ions and, where appropriate, a plasmin inhibitor. 1. Claims for the Contracting States : GR, ES A process for the production of a tissue adhesive, which comprises addition to an aqueous isotonic solution which has a pH of 7.5, which has been, where appropriate, pasteurized and, where appropriate, sterilized by filtration, and which contains at least 16 g/l human fibrinogen, 2 g-atoms of calcium per mol of fibrinogen and 1-6 g/l L-arginine monohydrochloride, of sufficient of a solution, which has, where appropriate, been pasteurized, of human factor XIII, of human albumin, of prothrombin concentrate, of antithrombin III and of aprotinin and, where appropriate, Na glutamate and isoleucine that the freeze-dried solution contains, in 1/4 of the volume dispensed into the container, these substances in the following concentration ranges : 65-115 mg/ml of human fibrinogen, 40-80 U/ml of factor XIII 4-40 mg/ml of human albumin, 1-50 IU/ml of PPSB (prothrombin factors), based on F II (prothrombin) 0.01-50 IU/ml of antithrombin III and, where appropriate, 1-10, 000 KIU of aprotinin/ml and 0-20 g/l of Na glutamate and 0-20 g/l of isoleucine.
Patent GR-3003660-T3 (GR)
IPC: C07D499/88
Filed: 1992-01-27
Abstract: A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
Patent GR-3015448-T3 (GR)
Title: Clean-room ceiling module.
Inventor: JUNG UDO
IPC: F24F3/16
Filed: 1995-03-17
Abstract: PCT No. PCT/EP92/01297 Sec. 371 Date Nov. 30, 1993 Sec. 102(e) Date Nov. 30, 1993 PCT Filed Jun. 10, 1992 PCT Pub. No. WO93/01453 PCT Pub. Date Jan. 21, 1993.A module for the construction of a cleaning room ceiling has a housing which can be fitted like a tile in the ceiling and which is divided internally into three chambers. A fan in an upper false floor draws air into the housing along an upper chamber which is aligned with a sound-damping lining. Sound-damping baffles are provided on the underside of the upper floor and the upper side and lower floor in the intermediate chamber and the bottom of the lower chamber is closed by high efficiency particle filters.
Patent GR-3017042-T3 (GR)
Title: Compositions containing ibuprofen and S-(+)-ibuprofen, and process to prepare them.
Inventor: BAUER K PROF DR CHEM
IPC: A61K9/20
Filed: 1995-08-08
Abstract: The invention relates to a composition with improved tablettability, which contains ibuprofen and/or S-(+)-ibuprofen and conventional pharmaceutical additives and/or pharmaceutical vehicles, which is characterised in that it contains calcium ibuprofen salt and/or calcium S-(+)-ibuprofen salt, and to a process for preparing it.
Patent GR-3017445-T3 (GR)
Title: (+)-Isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents.
Inventor: RICE KENNER C
IPC: A61P11/14
Filed: 1995-09-20
Abstract: A class of epoxymorphinan derivatives is described having use as antitussive agents. Compounds of this class are characterized in having antitussive potency but lacking narcotic side effects. Compounds of interest are those of the formula <CHEM> wherein R<1> is selected from hydroxy, alkylcarboxyl, alkoxy and phenoxy; wherein R<2> is selected from hydrido, alkyl, acyl and phenyl; wherein R<3> is selected from <CHEM> wherein each of R<5>, R<6>, R<7> and R<8> is independently selected form hydrido, alkyl, phenyl and phenalkyl, wherein R<4> is selected from hydrido, alkyl, cyano, cycloalkyl, cycloalkylalkyl, cycloalkylcarbonyl, allyl, phenyl, benzyl, phenethyl and phenpropyl; and wherein any of the foregoing R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> substituents having a substitutable position may be substituted with one or more groups selected from hydroxy, halo, alkyl and cycloalkyl; or a pharmaceutically-acceptable salt thereof.
Patent GR-3018754-T3 (GR)
Title: Use of biphosphonates for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes.
Inventor: BILLER SCOTT A
IPC: A61K31/66
Filed: 1996-01-23
Abstract: A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amount of a protein-prenyl transferase inhibitor which is a bisphosphonate or analog thereof.
Patent GR-3020704-T3 (GR)
Title: Process for the preparation of procaine
Inventor: JUERGENS ERNST A
IPC: C07C229/60
Filed: 1996-08-01
Abstract: The process is characterised in that p-nitrobenzoic acid is esterified in butanol in a manner known per se, the nitro ester is catalytically hydrogenated without intermediate isolation and the resulting hydrogenation solution, after removal by distillation of the majority of the alcohol used, is reacted with diethylaminoethanol in the presence of alkali metal alkoxides at 80 to 150 DEG C, preferably 80 to 130 DEG C, and in the course of this the alcohol liberated is continuously removed in vacuo.
Patent GR-3022069-T3 (GR)
Title: Hollow fiber filter cartridge and method of manufacture.
Inventor: BRINDA PAUL D
IPC: B01D63/04
Filed: 1996-12-18
Abstract: A method of sealingly coupling a hollow fiber bundle having first and seconds ends to a porous collar having first and second peripheral edges, at least one of which is coupled to the inner ledge of a casing for encasing said bundle of hollow fibers is disclosed. The method broadly includes providing a porous collar having first and second outer peripheral edges; providing a casing having first and second longitudinal ends, the casing defining a central chamber, the chamber having first and second open ends wherein the longitudinal ends of the casing each include an inner lip proximal to the open end; coupling the first outer peripheral edge of the porous collar to the inner lip of the casing; retaining a bundle of hollow fibers having first and second longitudinal ends within the chamber; permeating the longitudinal ends of the hollow fiber bundle with a fluid impermeable material; joining the porous collar to the fluid impermeable material by penetration of the material into the porous collar; and curing the fluid impermeable material. The method provides a fluid impermeable seal between the casing and the individual hollow fibers. The seal prevents the unfiltered fluid from coming into contact with filtrate and provides a strong bond that is impervious to dry heat and steam sterilization at temperatures ranging from 100 DEG  C. to 150 DEG  C. and pressures from 10 psi to 60 psi.
Patent GR-3025120-T3 (GR)
Title: Alkaloids from mappia foetida, the use thereof and formulations containing them.
Inventor: BOMBARDELLI EZIO
IPC: A61K31/12
Filed: 1997-10-23
Abstract: The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in water, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to have pharmacodynamic properties but also to be insoluble in water. The particular water solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.
Patent GR-3026565-T3 (GR)
Title: Fixing device for the collapsible frame of an umbrella-type clothes dryer
Inventor: OHM HEINZ JOSEF
IPC: D06F57/04
Filed: 1998-04-07
Abstract: A fastening device is for the expanding frame of a laundry stand and has holders (3) for the arms (3) of the frame. The holders (5) are shaped on an upright tube (1) with a sliding holding star (2). A holder (3) takes the form of a box-like arm mount which is open at the top and has receiving slit (10) for an axis (4) premounted in the end sections of the arms (3).
Patent GR-3027766-T3 (GR)
Title: Aqueous suspension of silica and aluminium sulfate or alum, processes for its preparation and uses thereof
Inventor: PRAT EVELYNE
IPC: C01F7/74
Filed: 1998-08-28
Abstract: New aq. suspensions of silica and an Al cpd. chosen from the sulphate, basic sulphate, an alum. of a mixt. have a pH less than 4 and a dry material content of 10-50% wt. After standing for 48 hrs. they form gels which are reversible at a low shear rate. Also claimed are their prepn. and use. The prodn. are used in cement compsns., based on cement and water, mortars and concrete, the prepn. of paper pulps, in water treatment and as constituents of mineral glues for paper-cartons and in construction materials. The new prodn., containing precipitated SiO2 and an Al sulphate. They have a tendency to form gels on standing, thus avoiding sedimentation or sepn. on storage. The suspensions are stable for weeks or even months. The gels formed are totally reversible, reverting to a homogeneous suspension, with light stirring, of low viscosity and easy pumpability.
Patent GR-3029439-T3 (GR)
Title: Rapamycin formulations for oral administration.
Inventor: WARANIS ROBERT PAUL
IPC: A61K47/26
Filed: 1999-02-17
Abstract: The present invention comprises novel oral rapamycin formulations which contain about 0.01 to about 10.0 grams of rapamycin per each 100 ml of the formulation, and a solvent system comprising from about 0.1 to about 10 % by volume of surfactant, from about 0 to about 25 % by volume of inert solvent, and from about 65 to about 99.95 % by volume of a lecithin or phospholipid solution.
Patent GR-3030462-T3 (GR)
Title: Prevention and treatment of cytomegalovirus using aminopeptidase.
Inventor: ZAIA JOHN A
IPC: G01N33/569
Filed: 1999-06-09
Abstract: A method for the prevention or treatment of human cytomegalovirus is described. Aminopeptidases, preferably in soluble form is administered exogenously to the patient. The invention involves the discovery that aminopeptidases are a CMV surface protein involved in post-binding events in the CMV infection process. The invention includes the discovery that AP, including specifically APN, on the surface of the virion and on the surface of the cell is involved in the CMV infection process.
Patent GR-3032149-T3 (GR)
Title: Carrying case having detachable step stool
Inventor: CARR ARTHUR G
IPC: A47B83/00
Filed: 1999-12-15
Abstract: A carrying case assembly includes a carrying case portion provided with a first interior cavity and a first top opening and a step stool portion provided with a second interior space and a bottom opening. The bottom of the step stool portion is attached to the top of the carrying case portion such that the first and the second interior space, together, form a third interior space. The step stool portion is removable from the carrying case portion and is adapted to support a person thereon.
Patent GR-3033372-T3 (GR)
Title: Inhaler apparatus with optimisation chamber
Inventor: BELL JOHN H
IPC: A61M15/00
Filed: 2000-05-05
Abstract: The device comprises an actuator body 20 adapted to receive a medicament dispenser 40, and medicament delivery outlet means 23 through which medicament is delivered in an airstream in response to inhalation by a user, the outlet means being provided with an optimisation chamber 60 having a mouthpiece 61. The chamber has a volume in the range from 20 ml to 200 ml and is optionally fitted with baffle means serving to ensure that the larger droplets/particles are retained within the chamber so that only the smaller droplets pass through the oro-pharynx to enter the trachea etc. The actuator body and optimisation chamber may be engageable by a push-jet connection or may be pivotally connected to form a unitary device. <IMAGE>
Patent GR-3035986-T3 (GR)
Title: Method and device for securing the operating range of an emptying device
Inventor: ZHANG HAIPING DR ING
IPC: G01V8/12
Filed: 2001-05-31
Abstract: The lateral regions adjacent to the emptying device or devices are protected by barriers (6,7). At least during one time period, i.e. the monitoring phase, of the emptying process, the introduction region between the barriers is protected by a light barrier (18,8,9,14). If the light barrier is interrupted, the emptying process is prevented or interrupted. The light barrier is activated when the emptying device has reached a defined lifting height or when the waste container is locked onto the emptying device.
Patent GR-3036629-T3 (GR)
Title: Multiple flow path device for oral delivery of discrete units
Inventor: ROTH NATHAN
IPC: A61K9/00
Filed: 2001-09-17
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
Patent DE-3382811-T4 (DE)
Inventor: COMAI LUCA
IPC: C12Q1/48
Filed: 1983-11-11
Granted: 1998-03-19
Abstract: Enhanced resistance to glyphosate, an inhibitor of the aromatic amino acid biosynthesis pathway, is imparted to a glyphosate sensitive host A mutated aroA gene is employed which expresses 5-enolpyruvyl-3-phosphoshikimate synthetase (EC: 2.5.1.19) (ES-3-P synthetase). Methods are provided for obtaining the aroA mutation which provides the enzyme resistant to inhibition by glyphosate, means for introducing the structural gene into a sensitive host, as well as providing a method of producing the enzyme.The E. coli strain C600(pPMG1) has been deposited at the A.T.C.C. on Dec. 14, 1982 and been given A.T.C.C. accession no. 39 256.
Patent DE-69519443-T4 (DE)
Inventor: OZ DAN
IPC: H04N7/18
Filed: 1995-03-03
Granted: 2001-09-13
Abstract: An optical viewing device (10) comprises a tubular camera casing (16) having a front end and a rear end and including near its front end an image sensor (38) for transforming optical images to electric signals, and optics (27) for focusing on to the image sensor and filtering optical images acquired from objects located in a region in front of the optics. The device additionally comprises a sleeve with an open rear end, which sleeve is detachably connectable to the rear end of the tubular camera casing and provides a socket for the user's finger; the socket being sealed off from the optics and the image sensor. An optical viewing system includes the described optical viewing device adapted for mounting on a user's finger, a separate camera control unit wire-linked to the device, and a remotely-located video monitor.