Patent SG-11201811183W-A (SG)
Title: Anti-infective heterocyclic compounds and uses thereof
Inventor: KIRSEBOM LEIF
IPC: A61K31/5415
Filed: 2017-06-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111 0 11111111111111111111111111111011011110 111111111011111111111 011111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/222466 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07D 417/12 (2006.01) C07D 513/06 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, C07D 417/14 (2006.01) A61K 31/5415 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 279/20 (2006.01) A61K 31/538 (2006.01) KM, CO7D 279/28 (2006.01) A61P 31/00 (2006.01) ML, MR, NE, SN, TD, TG). CO7D 513/04 (2006.01) Published: (21) International Application Number: — with international search report (Art. 21(3)) PCT/SE2017/050697 — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) 22 June 2017 (22.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1650906-9 23 June 2016 (23.06.2016) SE (71) Applicant: BIOIMICS AB [SE/SE]; Sandstensvagen 7, 752 67 Uppsala (SE). (72) Inventors: KIRSEBOM, Leif; Vreta Strandvag 20, 755 _ 91 Uppsala (SE). UPADHAYAYA, Ram Shankar; Her- = ragsvagen 197, lgh 1203, 752 69 Uppsala (SE). KETHIRI, Raghava Reddy; H No. 227, Shri Nilaya, Karishma Hills, Subramanya Pura Post, Bangalore 560 061 (IN). VIRTA- =_ NEN, Anders; Sandstensvagen 7, 752 67 Uppsala (SE). (74) Agent: ZACCO SWEDEN AB; P.O. Box 5581, Val- hallavagen 117N, 114 85 Stockholm (SE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = = (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 (54) Title: ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF V::+ (57) : The present invention relates to heterocyclic compounds of Formula I useful as R 1 R 2 71' anti-infective agents. The present invention further relates to a method of treating an infection I el N e•1 4 --..... R x 1 „_ , N X 2 ' ',, -\"--- ' '''''' '-' .* * 1 X5 by administering such compounds, and to pharmaceutical compositions comprising such com- pounds. I I X 4*I''' R3 IN -- --- '\"- --'' '' , A , '\" ---- `• X 3 ';. l'* R 8 N (I) C