baber/WOPTO huggingface dataset:
Patent CA-2507863-A1 (CA)
Title: Methods and materials for modulating trpm2
Inventor: HART LUCY VULCHANOVA
IPC: A61K38/00
Filed: 2003-12-04
Abstract: The invention relates to antisense oligonucleotides, compositions and methods useful for modulating the expression of TRPM2. The compositions comprise antisense oligonucleotides, particularly antisense oligonucleotides targeted to nucleic acids encoding TRPM2.
Patent CA-2509802-A1 (CA)
Inventor: ROHEE RENE
IPC: B60N2/90
Filed: 2005-06-13
Abstract: Mécanisme d'articulation pour siège de véhicule destiné à relier deux éléments appartenant au siège, ledit mécanisme d'articulation comportant des premier (20) et deuxième (22) flasques rigides s'étendant dans des plans parallèles et destinés à être fixés respectivement aux deux éléments de siège, et un mécanisme de réglage reliant les premier (20) et deuxième (22) flasques et adapté pour permettre un réglage angulaire relatif entre lesdits flasques. Le premier flasque (20) est emprisonné contre le deuxième flasque (22) par au moins un gousset (50) rigide annulaire qui est soudé contre la face interne du deuxième flasque (22).
Patent CA-2512738-A1 (CA)
Inventor: MEIER CHRISTIAN
IPC: A61K9/00
Filed: 2003-11-21
Abstract: The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth.  According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerised C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass;  the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 ~m or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
Patent CA-2514079-A1 (CA)
Inventor: BEBOULENE JEAN-JACQUES
IPC: G01N33/28
Filed: 2005-07-28
Abstract: L'invention porte sur un procédé et un dispositif d'analyse intégrée pour la caractérisation d'un échantillon d'hydrocarbures en fractions de distillatio n, dans lequel : a) on réalise une distillation simulée de manière à séparer l'échantillon en une fraction légère et au moins une fraction lourde, b) on analyse en détail la fraction légère, c) on recueille au moins une fraction lourde après sa séparation, et d) on analyse en détail au moins une fraction lourde.
Patent CA-2514231-A1 (CA)
Title: Uses of anti-insulin-like growth factor i receptor antibodies
Inventor: PAGE KELLY LYNN
IPC: A61P35/00
Filed: 2004-02-03
Abstract: The present invention relates to a therapeutic method comprising administering anti~IGF-IR antibodies, particularly human anti-IGF-IR antibodies to a subject for the treatment of certain disorders preferably in conjunction with administration of another therapeutic agent. The invention further relates to pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment.
Patent CA-2521177-A1 (CA)
Inventor: ACKERMAN ALAN H
IPC: A61K38/48
Filed: 2004-04-16
Abstract: Use of a botulinum toxin for making a medicament for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions o r compulsions can be, for example, trichotillomania, repetitive hand washing, compulsive body rocking, dermatillomania, eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration of a botulinum toxin.
Patent CA-2521680-A1 (CA)
Title: Self retaining sliding bar interlock for circuit breaker
Inventor: GULA LANCE
IPC: H01H71/12
Filed: 2005-09-29
Abstract: An interlock mechanism for preventing a first circuit breaker having a first actuating mechanism and a second circuit breaker having a second actuating mechanism from simultaneously being in a closed condition. The interlock mechanism includes a frame, a sliding bar slideably mounted within the frame, and one or more retaining protrusions extending outwardly from one or more inner edges of the frame. The sliding bar is movable between a first position and a second position. In the first position the sliding bar blocks a path of movement of the first actuating mechanism and in the second position the sliding bar blocks a path of movement of the second actuating mechanism. The one or more retaining protrusions frictionally engage the sliding bar when the sliding bar is in the first position and holds it in place, preferably with a frictional force sufficient to resist the force of gravity and/or vibrations.
Patent CA-2522943-A1 (CA)
Inventor: CONROY JOHN D JR
IPC: B64D10/00
Filed: 2004-04-15
Abstract: A noninvasive system for monitoring the oxygen saturation level of a person subjected to reduced atmospheric pressure for avoiding hypoxemia. The system monitors a person's oxygen saturation level (26, 126), comparing the saturation level to a predetermined level (41). When the measured saturation level is less than the predetermined level, the person is then supplied with an oxygen mixture (47, 147) for increasing the subject's oxygen saturation level to a safe level. The person's exposed reduced atmospheric pressure is also compared with a predetermined range of pressure levels (74, 89). If this predetermined range of pressure levels is exceeded or maintained for a predetermined time duration, the person is then supplied with an oxygen mixture (88). Additionally, a device (400) is provided for performing oxygen flight planning calculations for estimating oxygen usage for a predetermined flight plan that is based on the above system.
Patent CA-2523044-A1 (CA)
Title: Performance management by results-based scorecarding
Inventor: BOIVIN PIERRE Y
IPC: G06Q10/06
Filed: 2004-05-07
Abstract: Published without an Abstract
Patent CA-2523088-A1 (CA)
Title: Cement compositions with improved corrosion resistance and methods of cementing in subterranean formations
Inventor: BROTHERS LANCE E
IPC: E21B33/13
Filed: 2004-04-06
Abstract: The present invention provides cement compositions with improved corrosion resistance, and methods of using the compositions in a subterranean formation.  The cement composition comprises a high alumina cement, vitrified shale, a soluble phosphate, and water sufficient to form a slurry. Optionally, other additives may be included, such as accelerants, retardants, dispersants, and the like.
Patent CA-2524118-A1 (CA)
Inventor: DEPPISCH REINHOLD
IPC: A61L28/00
Filed: 2004-05-24
Abstract: The present invention relates to a biocompatible polymer composition for an article having a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids and/or therapeutic fluids for removal or infusion. The invention also relates to a method for the preparation thereof, an article comprising the biocompatible polymer composition and a use thereof.
Patent CA-2525187-A1 (CA)
Inventor: HARTMAN STEPHAN DAVID CORNELIS
IPC: F16G13/02
Filed: 2004-05-10
Abstract: The invention relates to the use of steel alloys in chain modules of hinge conveyor chains, in particular to alloys of stainless steel for use in such chain modules manufactured from stainless steel. A chain module according to the invention comprises at least one link from ferritic-pearlitic stainless steel and at least one chain pin, which chain pin comprises a steel alloy which is substantially non-seizing to the ferritic-pearlitic stainless steel of said link. The chain pin comprises a steel alloy with more than 0.6 wt.% of carbon and more than 12 wt.% of chromium.
Patent CA-2528123-A1 (CA)
Title: Laser pulse generator
Inventor: ORON RAM
IPC: H01S5/50
Filed: 2004-06-01
Abstract: A laser pulse generator utilizes an optical modulator to generate wave pulses having customized temporally shaped pulses. A continuous wavelength laser source inserts optical energy into an optical pulse generator, which in turn emits light into an amplification stage. The amplification stage emits light pulses corresponding to user-defined amplitudes and pulse shapes. The optical pulse generator comprises an optical modulator which modulates incoming light in accordance with temporal waveforms defined by an electronic waveform generator.
Patent CA-2529917-A1 (CA)
Inventor: CONNOLLY DANIEL T
IPC: G01N33/68
Filed: 2004-06-17
Abstract: The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardiomyocytes. In some embodiments, the GPCR is coupled to Gq. In some embodiments, the GPCR increases the intracellular level of inositol 1,4,5-triphosphate (IP3). In some embodiments, a modulator of the GPCR is a modulator of cardiomyocyte hypertrophy. The present invention further relates to methods of using a modulator of the GPCR.  Preferred modulators are inverse agonists and antagonists. Inverse agonists and antagonists of the invention are useful as therapeutic agents for the prevention or treatment of heart disease, including hypertrophic cardiomyopathy and congestive heart failure, in particular hypertrophic cardiomyopathy resulting from post-myocardial infarction remodeling, cardiac valve disease, sustained cardiac afterload, myocarditis, and familial hypertrophic cardiomyopathy.
Patent CA-2531790-A1 (CA)
Inventor: WATANABE FUMIO
IPC: C07C231/02
Filed: 2004-07-09
Abstract: A compound which has high HCV replication inhibitory activity and is hence useful in the prevention of and treatments for viral infectious diseases, especially liver diseases attributable to HCV infection; a process for producing the compound; an intermediate useful for the production; and a medicinal composition containing the compound. The compound is any of a compound represented by the formula (I): [wherein A represents -(CH2)n-, etc.;  B represents -(C=O)-, etc.; D represents -(CH2)m-R', etc.; E represents hydrogen, etc.; G represents -(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2, and R3 are the same or different and each represents hydrogen, etc.], a prodrug thereof, and a pharmaceutically acceptable salt of either.
Patent CA-2533776-A1 (CA)
Title: Chipping machine with cutting blades and method for fabricating the cutting blades
Inventor: FREICHEL THOMAS
IPC: B27G13/02
Filed: 2006-01-24
Abstract: This invention relates to a cutting blade for a chipping machine, with the cutting blades being designed so that splitting blades extending at least essentially perpendicular to a cutting edge of the cutting blade are present, which project beyond the cutting edge and/or stand out from the cutting edge, with the cutting blade consisting of a blade support and a blade head, with the blade head corresponding with a friction fit to the blade support, and with the blade head being designed as a disposable component.
Patent CA-2534148-A1 (CA)
Inventor: SERBOUSEK JILL
IPC: G16H70/60
Filed: 2004-07-28
Abstract: Systems and methods for documenting an encounter and communicating about same are described. The systems and methods of this invention generally comprise an electronic records system for creating and maintaining information in electronic records; a point-of-encounter system in communication with the electronic records system, wherein the point-of-encounter system allows a scribe to document the encounter into a predetermined electronic record; and a library of event-specific templates usable for documenting the encounter. The systems of this invention allow new dynamically-generated templates to be created and added to the library of event-specific templates as needed. These systems may comprise various other components, such as, a website comprising information about a specific event; an access system that is capable of allowing a user to view, create and store details in their own electronic record in the electronic records system; a communications system for providing information to recipients; a library of documents for communicating information to the recipients; a compliance system for identifying whether or not each electronic record is complete; and/or a purchasing system capable of allowing goods and supplies to be purchased via a website.
Patent CA-2534364-A1 (CA)
Inventor: REYNOLDS JASON M
IPC: A61B/
Filed: 2004-08-09
Abstract: The present invention, in an exemplary embodiment, provides a therapeutic medical appliance, delivery device and method of use. In particular, plug therapeutic medical appliances are provided that allow for the intervenfional treatment of pulmonary disorders such as defects characterized by pulmonary blebs and/or diffused destructive parenchymal disease. The plug therapeutic medical appliances themselves combine many of the excellent characteristics of both silicone and metal therapeutic medical appliances while eliminating the undesirable ones. In particular, these therapeutic medical appliances are preferably self-expanding in nature and allow the predetermined differential selection of relative hardness/softness of regions of the therapeutic medical appliance to provide additional patient comfort. An exemplary embodiment also provides a family of delivery devices that facilitate flexibility, durability and/or proper installation of one or more medical appliances in a single procedure. Moreover, the preferred embodiment of the delivery device provides for the reloading of the delivery device with additional medical appliances for additional inferventional procedures.
Patent CA-2535784-A1 (CA)
Inventor: PERERA PAYAGALAGE SURENDRE GER
IPC: A61C7/10
Filed: 2004-08-06
Abstract: The invention provides a corrective orthodontic brace wherein a spring means acts upon one or more molars to move them towards the back of a user's mouth.  The forces are transmitted to a support plate shaped to fit closely on the keratinised tissue of a user's mouth.
Patent CA-2538681-A1 (CA)
Title: A method of baking frozen dough pieces
Inventor: KEMP DEREK
IPC: A21D8/06
Filed: 2004-01-26
Abstract: The present invention relates to a method of baking frozen dough pieces using a multi-step baking program that yields a baked product that is essentially indistinguishable from a baked product prepared from freshly prepared non-frozen dough. More particularly, the invention is concerned with a method of baking a frozen dough piece in an oven using a multi-step baking program, said method comprising a first step of heating the frozen dough piece in an oven comprising a humid atmosphere with a dewpoint of at least 40 ~C for a sufficiently long period to completely thaw the exterior of the dough piece to a depth of at least 5 mm, preferably of at least 8 mm, and a subsequent step of baking the dough piece in an oven comprising a dry atmosphere with a temperature of at least 140 ~C, to obtain a baked product exhibiting a soft crumb and a crispy, browned crust.
Patent CA-2539613-A1 (CA)
Inventor: TSUBOTA KAZUO
IPC: C12Q1/02
Filed: 2004-03-25
Abstract: A process for producing a cell sheet, comprising culturing cells up to a state of saturation on the surface of a support having its surface coated with fibrin, continuing the culturing for a period of time sufficient to achieve decomposition of the fibrin at cell bottom surface and detaching the cultured cells in the form of a sheet from the support surface. Further, there are provided a support for preparation of cell sheet having its surface coated with fibrin; and a composition for coating the surface of a support for preparation of cell sheet with fibrin, which composition is characterized by containing fibrinogen and thrombin. Cell sheets can be produced by simple operation using a support coated with commercially available familiar material whose safety is ensured.
Patent CA-2541604-A1 (CA)
Title: Locator and closure device and method of use
Inventor: GINN RICHARD S
IPC: A61F2/06
Filed: 2004-10-12
Abstract: An apparatus for sealing a vascular puncture and for properly locating and deploying a sealing member. The apparatus comprises a lumen which extends from an opening in the distal region of the apparatus to another opening in the proximal region of the apparatus. A sealing member is located at the end of the lumen. When the distal opening is positioned within the blood vessel lumen, blood flows through the distal opening, through the lumen and out of the proximal opening indicating that the sealing member is within the blood vessel lumen. When the sealing member is withdrawn from the vessel lumen, it blocks the blood flow into the distal opening. The sealing member may be further withdrawn a predetermined distance so that no part of the sealing member extends into the blood vessel lumen. The sealing device is then detached from the delivery apparatus to seal the vascular puncture.
Patent CA-2543269-A1 (CA)
Title: Control method and control system for a controllable pitch marine propeller
Inventor: ROBSON MARTIN
IPC: B63H3/00
Filed: 2004-09-06
Abstract: A control method and system for a controllable pitch marine propeller including operating modes comprised of a manoeuvering mode and a cruise mode and check modes comprised of an engine check mode and propeller check mode.  The cruise mode provides for wide open throttle acceleration and power stop.  Smooth transition sub-modes are provided for providing smooth transition between cruise mode and manoeuvering mode and vice versa. The system operates by a lever (28) which controls a pitch control unit (10) which in turn controls engine speed and also the pitch of propeller blades (12) of propeller (14). Thus, dependent on the position of the control lever (28) in either manoeuvering mode or cruise mode, an appropriate engine speed and propeller pitch is selected automatically for driving a watercraft.
Patent CA-2543275-A1 (CA)
Title: Process for the preparation of gabapentin
Inventor: ARRIGHI KATIUSCIA
IPC: C07C233/08
Filed: 2004-11-09
Abstract: The present invention relates to an improved process for the preparation of gabapentin and, more particularly, to an improvement of the preparation reaction of 1,1-cyclohexanediacetic acid monoamide, intermediate utilized in the preparation of gabapentin.
Patent CA-2544481-A1 (CA)
Title: Compositions and methods for detecting severe acute respiratory syndrome coronavirus
Inventor: SCHOLL DAVID R
IPC: C12Q1/68
Filed: 2004-11-03
Abstract: The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
Patent CA-2545230-A1 (CA)
Inventor: LAVINE STEVEN DAVID
IPC: G06F17/30
Filed: 2003-11-10
Abstract: Information regarding the structure of information in a content database (CD) is maintained in a structure database (10). The structure database (10) is used to correlate the data structure of a query to the structure of the content database (CD), in order to determine that information in the content database which needs to be provided to a searcher in response to the query. In one embodiment, this search method is used in an online forum, and the forum maintains a reputation score for users with respect to given subject matter. The reputation score is dependent upon the quality of user's participation in the forum. A user's reputation score depends upon the evaluation by other of information he posts and upon the user evaluating information posted by others.
Patent CA-2546805-A1 (CA)
Title: De-icer apparatus
Inventor: PRESCOTT MARK R
IPC: C09K3/18
Filed: 2004-11-18
Abstract: The de-icer apparatus uses the warmer water below an ice cap on a fishpond to maintain an opening in the ice cap for venting gases generated below the ice cap. The de-icer apparatus uses a low voltage heater to warm the water entering the lower end of the apparatus and moves the water by convection to the upper end of the apparatus. In one embodiment, the heated water is moved out of the upper end of the housing to prevent the formation of ice. In another embodiment, the housing provides a chimney effect for venting gas and melting snow.
Patent CA-2547698-A1 (CA)
Inventor: LAUKS IMANTS
IPC: G01N27/401
Filed: 2003-11-27
Abstract: Planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object is to provide unit-use disposable sensors of a very simple and economical construction, preferably with only a single membrane coating on an electrode. The devices are potentiometric salt-bridge reference electrodes constructed with a heterogeneous membrane coating of a conductor.  The heterogeneous membrane is a formulation that concurrently supports non-volatile species transport through an electrolyte compartment and gas transport through a hydrophobic compartment.
Patent CA-2549014-A1 (CA)
Inventor: DRACKER ROBERT
IPC: A61B5/00
Filed: 2004-12-22
Abstract: Described is a method to determine the viability of cells by measuring the absolute and relative rate of metabolic activity and/or integrity of the cell membrane through the use of vibrational spectroscopy. The use of deuterated agents facilitates detection of changes associated with a change in viability.
Patent CA-2552536-A1 (CA)
Title: Indelible ink jet ink composition
Inventor: FOLKERS JOHN P
IPC: B41J2/01
Filed: 2005-01-06
Abstract: Disclosed is an ink jet ink composition that forms indelible images on porous or semiporous substrates. The ink composition comprises a liquid carrier, a first colorant that is soluble in the carrier but insoluble or substantially insoluble in water, and a second colorant composition comprising a pigment, the second colorant composition being dispersible in the carrier. The second colorant composition is insoluble or substantially insoluble in the carrier.  The images are difficult or impossible to remove or wash out by the use of aqueous and/or nonaqueous liquids.
Patent CA-2553410-A1 (CA)
Inventor: KOHLI MARKUS
IPC: G01N21/39
Filed: 2006-07-25
Abstract: The gas detector device comprises at least a VCSEL source and at least a light sensor for detecting a light beam having passed through a sample chamber containing a given gas to be detected. The detection signal of the sensor directly provided to or is time derivated by an electronic derivator and then provided to respective lock-in amplifiers in order to generate a two different 2f-detection, f being the frequency of a wavelength modulation of the source, and thus to provide two corresponding measuring signals the division of which gives a precise value of the gas concentration. The invention uses at least a first modulation reference signal at twice and a second modulation reference signal at twice of the modulation frequency of the laser source. Providing at least a first 2f modulation reference signal has advantages over the prior art, because by using such a reference modulation signal it is possible measure the absolute intensity and therefore to receive the same result at different temperatures or at mode hopping of the laser. A further advantage is that the measurement accuracy is independent from the gas concentration.
Patent CA-2555262-A1 (CA)
Title: 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors
Inventor: VIOGLIO SERGIO
IPC: C07D495/04
Filed: 2005-02-02
Abstract: Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comrising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.