baber/WOPTO huggingface dataset:
Patent CA-2967649-A1 (CA)
Title: Synthetic peptides
Inventor: ANCSIN JOHN BELA
IPC: A61K38/10
Filed: 2015-11-20
Abstract: Provided herein are compositions comprising synthetic lipase-stimulating peptides, and methods of treating hypertriglyceridemia and other conditions and diseases therewith. In particular, synthetic peptides (AV-peptides) and peptidomimetics (AV-peptidomimetics) are provided that exhibit the lipase-stimulating activity of apoA-V or an enhancement thereof, as well as methods of use thereof. Provided herein are compositions comprising a peptide or polypeptide having less than 100% sequence identity with full length ApoA-V, encompassing a portion with at least 50% sequence identity with AV199-224.
Patent CA-2968847-A1 (CA)
Inventor: NAAMAN OFER
IPC: G05F3/08
Filed: 2015-11-12
Abstract: Selon un mode de réalisation, l'invention concerne un système de source de courant Josephson (14). Le système comprend une boucle de navette de flux (16) qui est couplée inductivement à un signal d'entrée de courant alternatif (AC). La boucle de navette de flux comprend une pluralité de jonctions Josephson espacées autour de la boucle de navette de flux et est configurée, lorsqu'elle est activée, pour déclencher séquentiellement la pluralité de jonctions Josephson autour de la boucle de navette de flux en réponse au signal d'entrée de courant alternatif afin de générer un courant de sortie continu fourni par l'intermédiaire d'une bobine d'inductance de sortie. Le système comprend également un injecteur de flux (18) qui est configuré pour activer et désactiver sélectivement la boucle de navette de flux en réponse à un signal d'entrée afin de commander une amplitude du courant de sortie continu.
Patent CA-2969020-A1 (CA)
Title: Anti-angiogenic properties of collagen v derived fragments
Inventor: RUGGIERO FLORENCE
IPC: C07K14/78
Filed: 2014-12-02
Abstract: The present invention relates to a peptide comprising an amino acid sequence at least 85% identical to the amino acid sequence as shown in SEQ ID NO. 1, wherein the residues Lys905, Arg909, and Arg912 contained therein are present, for use as a medicament, in particular for its use as an inhibitor of FGF-2 induced angiogenesis.
Patent CA-2969089-A1 (CA)
Title: Procede de preparation d'une composition de polymere-medicament
Inventor: PATEL KIRIT
IPC: A61K47/56
Filed: 2015-11-26
Abstract: La présente invention concerne une composition améliorée de polymère-ingrédient pharmaceutique actif ou inactif et son procédé de préparation. En particulier, la présente invention concerne une composition améliorée de polymère-ingrédient pharmaceutique actif ou inactif et son procédé de préparation, le monomère encapsulant des particules d'ingrédient pharmaceutique actif ou inactif au niveau moléculaire et, à l'aide d'un procédé de polymérisation contrôlée, le monomère devenant ledit revêtement polymère sur ledit ingrédient pharmaceutique actif ou inactif qui facilite la mise en uvre de la présente invention en une seule étape.
Patent CA-2973975-A1 (CA)
Title: Apparatus for forming barbs on a suture
Inventor: TRULL MICHAEL
IPC: A61B17/06
Filed: 2004-05-13
Abstract: An apparatus for cutting barbs into a suture having a filament supply. The apparatus also has an in-feed collet for holding one end of a filament threaded therethrough. Further the apparatus has an out-feed collet for holding a second end of a filament threaded therethrough. Additionally, the apparatus has a holder positioned between said in-feed and out-feed collets for holding a filament suspended between the in-feed and out-feed collets. The apparatus also has a cutting assembly for cutting barbs in the filament tensioned between the in-feed and out-feed collets.
Patent CA-2974299-A1 (CA)
Title: Amplification d'acides nucleiques en emulsions multiples
Inventor: ABATE ADAM R
IPC: B01F3/08
Filed: 2016-02-03
Abstract: L'amplification d'acides nucléiques en émulsiosn multiples permet à des acides nucléiques contenus dans des systèmes biologiques, d'être détectés, quantifiés et/ou triés en fonction de leur séquence telle que détectée avec des techniques d'amplification d'acides nucléiques, par exemple, la PCR. Les acides nucléiques peuvent flotter librement ou être contenus à l'intérieur de structures vivantes ou non vivantes, y compris de particules, de virus et de cellules. Les acides nucléiques peuvent comprendre, par exemple, l'ADN ou l'ARN. L'invention concerne également des systèmes et des dispositifs destinés à être utilisés dans la mise en pratique des procédés de l'invention.
Patent CA-2976055-A1 (CA)
Inventor: THOMPSON RONALD H
IPC: B60C7/10
Filed: 2016-02-04
Abstract: A non-pneumatic tire for a vehicle or other machine. The non-pneumatic tire may comprise an annular beam. The annular beam may comprise a plurality of layers of different elastomeric materials. The annular beam may be free of a substantially inextensible reinforcing layer running in a circumferential direction of the non-pneumatic tire. The annular beam may comprise a plurality of openings distributed in the circumferential direction of the non-pneumatic tire. Such an annular beam may be part of other annular devices.
Patent CA-2977845-A1 (CA)
Title: Apparatus and methods for integrated sample preparation, reaction and detection
Inventor: BIRD DYLAN HILMER
IPC: C12Q1/68
Filed: 2011-02-23
Abstract: Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non- nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
Patent CA-2982110-A1 (CA)
Inventor: CHOI JOUYOUNG JASON
IPC: B64C27/39
Filed: 2017-10-10
Abstract: A proprotor system for tiltrotor aircraft having a helicopter mode and an airplane mode. The proprotor system includes a hub and a plurality of proprotor blades coupled to the hub such that each proprotor blade is operable to independently flap relative to the hub and independently change pitch. In the airplane mode, the proprotor blades have a first in-plane frequency greater than 2.0/rev.
Patent CA-2982267-A1 (CA)
Title: Novel dgat2 inhibitors
Inventor: ESCRIBANO ANA MARIA
IPC: A61K31/506
Filed: 2016-05-19
Abstract: The present invention provides compounds of the Formula below: [Formula should be inserted here] Where A, X, R, and R2-R3 are as described herein; methods of treating patients for hypertriglyceridemia and cardiovascular disease including dyslipidemia and atherosclerosis, and processes for preparing the compounds.
Patent CA-2982784-A1 (CA)
Title: Compositions et procedes de modulation de l'activite de la deshydrogenase a chaine courte
Inventor: MARKOWITZ SANFORD D
IPC: C07D495/04
Filed: 2016-04-14
Abstract: Composés et méthodes pour assurer la modulation de l'activité de la 15-PGDH, la modulation des taux de prostaglandine des tissus, le traitement de maladies, le traitement d'un état pathologique ou de troubles dans lesquels il est souhaitable de moduler l'activité de la 15-PGDH et/ou les taux de prostaglandine. Lesdits composés comprennent des inhibiteurs de 15-PGDH selon la présente invention.
Patent CA-2983327-A1 (CA)
Inventor: GRACE DUSTIN
IPC: B60L15/00
Filed: 2017-10-23
Abstract: A method of operating an electric vehicle having a battery system with a first battery module and a second battery module includes sending a triggering signal. And, in response to the triggering signal, selectively dissipating energy from the first battery module without dissipating energy from the second battery module.
Patent CA-2984483-A1 (CA)
Title: Hybrid battery, electrolyser and method for storing electrical energy
Inventor: MULDER FOKKO MARTEN
IPC: H01M8/18
Filed: 2016-04-28
Abstract: The invention provides a method of storing varying or intermittent electrical energy and one or more of hydrogen (H2) and oxygen (O2) with an energy apparatus, the method comprising: providing the first cell aqueous liquid, the second cell aqueous liquid, and electrical power from an external power source to the functional unit thereby providing an electrically charged functional battery unit and one or more of hydrogen (H2) and oxygen (O2) stored in said storage system, wherein during at least part of a charging time the functional unit is charged at a potential difference between the first cell electrode and the second cell electrode of more than 1.37 V.
Patent CA-2985823-A1 (CA)
Inventor: FOREMAN KENNETH W
IPC: C08G77/00
Filed: 2016-05-12
Abstract: Described herein are silicon based conjugates capable of delivering one or more pay load moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more pay load moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
Patent CA-2986140-A1 (CA)
Inventor: BABAKHANI AYDIN
IPC: G01R33/64
Filed: 2016-05-18
Abstract: An active cancellation system may be utilized to cancel interference, such as from transmitter leakage or self-interference in a transceiver of an electron paramagnetic resonance (EPR) spectrometer. The active cancellation system may be inserted between the transmitter and receiver. The active cancellation system may receive the output of the transmitter, and generate a cancellation signal with the same amplitude, but phase shifted relative to the self-interference signal. The cancellation system may include an attenuator/amplitude tuner, buffer, VQ generator, and phase shifter.
Patent CA-2990783-A1 (CA)
Title: Fiber arrangement member and optical wiring unit
Inventor: AGATA KATSUSHI
IPC: G02B6/46
Filed: 2018-01-04
Abstract: A fiber arrangement member and an optical wiring unit are used for guiding a plurality of optical fibers in various directions. These member and unit easily eliminate entanglement of the optical fibers at the time the wiring directions of optical fibers are changed to efficiently perform work of changing the wiring directions. The fiber arrangement member includes (a) a tubular fiber housing configured to house a plurality of optical fibers and (b) a plurality of fiber guide portions extending from a first end in an axial direction of the fiber housing toward side areas of the first end in different directions. The plurality of fiber guide portions are provided with guide grooves opening at sides of the guide grooves opposite to a second end in the axial direction of the fiber housing.
Patent CA-2991158-A1 (CA)
Title: System for dual management of anti-icing and boundary layer suction on an aerofoil of an aircraft, including a function of collecting the anti-icing air
Inventor: GUEUNING DIMITRI
IPC: B64C21/06
Filed: 2016-07-05
Abstract: The invention relates to a system for dual management of anti-icing and boundary layer suction for an aerofoil (4) of an aircraft, including: at least one anti-icing channel (44) and at least one suction channel (46); a device (26) for monitoring boundary layer suction and a device (28) for monitoring anti-icing; a duct (30b) for collecting the suction air communicating with said suction channel and a duct (30a) for supplying anti-icing air connected to the device (28) and communicating with the anti-icing channel. According to the invention, the device (26) comprises a three-way valve (26a, 26b, 26c) to which the duct (30b), a suction duct (29), and a duct for discharging the anti-icing air (31) are connected, the system also comprising a duct for collecting anti-icing air (64) connected to the anti-icing channel (44), and to the duct (30b).
Patent CA-2994586-A1 (CA)
Inventor: PAN YUANLONG
IPC: A61K31/202
Filed: 2008-12-19
Abstract: Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.
Patent CA-2994940-A1 (CA)
Inventor: JOHNSON ASHLEY BERNARD
IPC: E21B10/26
Filed: 2016-07-15
Abstract: L'invention concerne un outil rotatif pour le fraisage d'une colonne de production dans un trou de forage, comprenant au moins un dispositif de taille doté d'un corps de dispositif de taille et d'une surface de taille sur le corps. Chaque dispositif de taille a une forme et est disposé sur l'outil de manière à réduire la contrainte de traction dans le dispositif de taille, ce qui permet de réduire le risque que le dispositif de taille devienne émoussé ou cassé en cours d'utilisation et de produire des copeaux de rigidité réduite, moins susceptibles de former un blocage dans le trou de forage.
Patent CA-2994999-A1 (CA)
Title: Procedes et systeme permettant la reduction d'impuretes metalliques dans une solution electrolytique de raffinerie
Inventor: BENDER JACK
IPC: C22B3/38
Filed: 2016-08-22
Abstract: L'invention concerne des procédés permettant la réduction d'impuretés métalliques dans une solution électrolytique de raffinerie. Certains procédés consistent à mettre en contact une solution électrolytique de raffinerie comprenant une impureté métallique avec un ester de phosphate ayant une structure telle que représentée, dans laquelle R1 comprend un groupe alkyle linéaire, ramifié ou cyclique ou un groupe aryle, l'impureté métallique étant choisie dans le groupe constitué de fer, antimoine, arsenic, bismuth, étain et de combinaisons de ces derniers.
Patent CA-2997565-A1 (CA)
Title: Controleur pour charge inductive ayant un ou plusieurs enroulements inductifs
Inventor: SMOLENAERS STEFAN
IPC: H02P27/06
Filed: 2016-09-12
Abstract: La présente invention concerne un contrôleur pour une charge inductive sous forme d'un moteur électrique CC ayant un enroulement inductif. Le contrôleur comprend une première entrée destinée à tirer un courant de charge CC lors d'une première période à partir d'une première source d'énergie ayant la forme d'une rangée de batteries. La première entrée fournit un premier courant de charge CC aux batteries pendant une seconde période. Une seconde entrée tire un second courant de charge CC pendant la seconde période à partir d'une seconde source d'énergie ayant la forme d'une source d'alimentation CC. Un module de commande délivre des signaux de commande. Un premier circuit d'attaque et un second circuit d'attaque fonctionnent tous deux dans un premier état et un second état pendant la première période et la seconde période respectivement ; dans le premier état, les circuits d'attaque sont connectés à la première entrée et sont sensibles aux signaux de commande permettant de recevoir un courant de charge et d'exciter de façon sélective des enroulements afin de créer un couple dans un moteur.
Patent CA-2997678-A1 (CA)
Title: Belt driven sandwiching machine
Inventor: MITTAL ANKUSH B
IPC: A21C15/00
Filed: 2016-09-27
Abstract: A sandwiching machine includes a wafer conveying mechanism including multiple wafer conveyance rows and a pair of spaced apart belts. Each belt is positioned toward respective sides of the mechanism such that the belts are located laterally away from the wafer conveyance rows. A plurality of pusher bars extend laterally between the spaced apart belts and connected for movement therewith. Each pusher bar extends beneath a conveyance path of each wafer conveyance row and includes at least one pusher pin extending upward into the conveyance path. At least one stencil assembly extends over the wafer conveyance paths for depositing material onto wafers traveling along at least one of the wafer conveyance paths, wherein a deposit location of the stencil assembly is laterally spaced from each of the belts.
Patent CA-2998308-A1 (CA)
Inventor: SUGAWARA SHINSUKE
IPC: C08L15/00
Filed: 2016-09-13
Abstract: Provided is a nitrile rubber composition containing 50-90 parts by weight of a filler (B) and 0-29.9 parts by weight of an adipic acid ester-based plasticizer and/or ether ester-based plasticizer (C) per 100 parts by weight of a nitrile group-containing highly saturated copolymer rubber (A) containing 14 wt% to less than 21 wt% of a,ß-ethylenic unsaturated nitrile monomer units and having an iodine value of 120 or lower.
Patent CA-3001085-A1 (CA)
Inventor: LUCKING ULRICH
IPC: C07D498/18
Filed: 2016-09-30
Abstract: The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular disease, and their use as inhibitors of cyclin dependent kinase 9 (CDK9). The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
Patent CA-3003796-A1 (CA)
Title: Panel comprising an end-grain wood pattern, method for producing a pattern for such a panel, panel trading unit comprising at least one panel of this kind, embossing element for such a panel and decorative paper for such a panel
Inventor: DURNBERGER GERHARD
IPC: B44F9/02
Filed: 2016-08-24
Abstract: The invention relates to a panel (10) comprising a pattern (13) which comprises at least two decorative portions (22, 24), of which at least one (24) is an end-grain wood surface. According to the invention, all of the decorative portions (22, 24) display a wood pattern (13). Furthermore, two decorative portions (22, 24) that are adjoining each other along a joint line (S) are graphically processed adjacently to the joint line (S) so as to result in an appearance that the human eye perceives to be natural and continuous.
Patent CA-3004586-A1 (CA)
Title: Competitions sportives de fiction virtuelles representees visuellement
Inventor: Croci Alberto Murat
IPC: A63F13/828
Filed: 2016-11-06
Abstract: L'invention concerne un système de simulation visuelle de sports de fiction fournissant une expérience audiovisuelle qui permet à des participants de compétition et des spectateurs de visualiser un modèle de type jeu vidéo d'une compétition sportive de fiction virtuelle. Ces simulations peuvent se produire à tout moment entre au moins deux participants de compétition, tels que des mini-compétitions dans le contexte d'une ligue plus large. Une fois qu'une ligue est formée et que des listes d'équipes sont créées, des calculs numériques sont réalisés sur la base de statistiques d'athlète réel pour déterminer un état actuel de performance pour tous les athlètes virtuels dans un jeu. Cette analyse statistique est la base pour attribuer des variables de performance à chaque athlète virtuel, ce qui permet au système de calculer des valeurs de point numérique sur la base de la performance de chaque athlète virtuel et chaque équipe dans ce système de simulation visuelle de sports de fiction.
Patent CA-3005328-A1 (CA)
Inventor: KRIER BRICE
IPC: A61B17/86
Filed: 2016-11-08
Abstract: The invention relates to a non-continuous dual-thread bone screw (1) comprising a drive head (2) extended by an anchoring body (3) consisting of a conical-cylindrical core (4) on which at least two conical-cylindrical threads (5, 6) extend that anchor said screw (1) into bone, the anchoring body (3) including over the entire length thereof and from the drive head (2) anchoring portions of different profiles that provide anchoring corresponding to the different hardness and strength levels of the bone, said anchoring body (3) comprising below the drive head (2) a first anchoring portion (7) consisting of a conical core (4a) and two threads (5, 6) of cylindrical profile and identical pitch, a second anchoring portion (8) made up of a cylindrical core (4b) and a single cylindrical thread (5) along one-quarter turn, a third anchoring portion (9) having a cylindrical core (4b) and two threads (5, 6) of cylindrical profile along one-half turn, a fourth anchoring portion (10) including a cylindrical core (4b) and a single thread (6) of cylindrical profile along n turns depending on the overall length of the bone screw (1), a fifth anchoring portion (11) comprising a conical core (4a) and two threads (5, 6) of conical profile that form the tip of the bone screw.
Patent CA-3008434-A1 (CA)
Inventor: NAGELE ROBERT G
IPC: C40B30/04
Filed: 2016-12-14
Abstract: The present invention provides methods, compositions and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.
Patent CA-3009111-A1 (CA)
Inventor: KERN JEFFREY A
IPC: C08L99/00
Filed: 2016-12-21
Abstract: A method of lipopolysaccharide (LPS) extraction from gram negative bacterial cells is provided, said method comprising a step of extracting LPS from the gram negative bacterial cell in a LPS extraction solution comprising a salt, water, an alcohol, and a further organic solvent. Compositions and uses of the extracted LPS are also provided.
Patent CA-3010610-A1 (CA)
Inventor: KARP JEFFREY MICHAEL
IPC: C12N5/071
Filed: 2017-01-06
Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-ß inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
Patent CA-3010848-A1 (CA)
Title: Combinaison d'un compose de chromene et d'un second agent actif
Inventor: TALLEY JOHN J
IPC: A61K31/517
Filed: 2017-01-09
Abstract: La présente invention concerne une combinaison d'un composé de chromène ayant la structure de formule (I) : ou des sels pharmaceutiquement acceptables, et d'un second composé pouvant être sélectionné parmi un inhibiteur de PD-1, un inhibiteur de PD-L1, un inhibiteur de CTLA-4, un agoniste d'OX-40, un agoniste de CD137, un inhibiteur de LAG-3, un inhibiteur d'IDO, une protéine bispécifique, un inhibiteur d'EGFR, un inhibiteur de HER2 et un traitement immunostimulant et un procédé d'utilisation de cette combinaison pour traiter ou prévenir le cancer.
Patent CA-3011379-A1 (CA)
Inventor: SEAMAN ROBERT BRIAN
IPC: A63B5/11
Filed: 2017-01-27
Abstract: This falls in the technical field of trampoline safety enclosures, and more particularly to trampolines including a support frame for a safety enclosure. A trampoline comprising a safety enclosure net is supported by furcated enclosure members, furcated at a furcation location above the level of the jumping mat. The safety enclosure is attached to a set of enclosure supporting members such that the supporting furcated members support the top of the safety enclosure. It also extends to furcated trampoline enclosure supporting members and method of supporting a trampoline enclosure.