baber/WOPTO huggingface dataset:
Patent CY-1114755-T1 (CY)
Title: Ρυθμιση των τ κυτταρων
Inventor: PARDOLL DREW M
IPC: A61K35/12
Filed: 2013-11-14
Abstract: Τα ρυθμιστικά Τ κύτταρα (Treg) περιορίζουν την αυτοανοσία αλλά μπορούν επίσης να ελαττώσουν την ισχύ της ανοσολογικής απάντησης έναντι των παθογόνων ή έναντι των όγκων. Η κατανόηση του μηχανισμού της λειτουργίας των Τreg, και η χειραγώγηση των Τreg για θεραπευτικούς σκοπούς in vivo απαιτεί την ταυτοποίηση των εκλεκτικών υποδοχέων των Τreg. Μια συγκριτική ανάλυση της σειράς της γονιδιακής έκφρασης σε αντιγόνο- ειδικά CD4+ Τ κύτταρα που διαφοροποιούνται είτε προς έναν φαινότυπο δραστικών/ κυττάρων μνήμης ή προς έναν φαινότυπο ρυθμιστικών κυττάρων ανέδειξε την εκλεκτική έκφραση του LΑG-3 (CD223) στα Treg, ενός CD-4 σχετικού μορίου που προσδένει μόρια ΜΗC τάξης II. Η έκφραση του LΑG-3 σε CD4+ Τ κύτταρα συσχετίζεται με την κατασταλτική δράση των κυττάρων in vitro, και η έκτοπη έκφραση του LΑG-3 σε CD4 Τ κύτταρα επιφέρει κατασταλτική δραστηριότητα στα Τ κύτταρα. Αντισώματα προς το LAG-3 αναστέλλουν την καταστολή τόσο in vitro όσο και in vivo. Ο LΑG-3 χαρακτηρίζει τους πληθυσμούς των ρυθμιστικών Τ κυττάρων και συμβάλλει στη κατασταλτική τους δράση.
Patent CY-1116734-T1 (CY)
Title: Παραγωγα κινολινης και κινοξαλινης ως αναστολεις της κινασης
Inventor: PARTON ANDREW HARRY
IPC: A61K31/519
Filed: 2015-08-18
Abstract: Μια σειρά παραγώγων κινολίνης και κινοξαλίνης, τα οποία έχουν μια φθοριωμένη πλευρική άλυσο αιθυλίου και είναι επιλεκτικοί αναστολείς των ενζύμων Ρ13 κινάσης, και ως εκ τούτου είναι επωφελείς ως φαρμακευτικοί παράγοντες, παραδείγματος χάριν στην θεραπεία των φλεγμονωδών, αυτοάνοσων καρδιαγγειακών, νευροεκφυλιστικών, μεταβολικών, ογκολογικών, αλγαισθητικών και οφθαλμικών παθήσεων.
Patent CY-1117712-T1 (CY)
Title: Adcs δουοκαρμυκινης για χρηση στη θεραπεια ενδομητριου καρκινου
Inventor: SANTIN ALESSANDRO DAVIDE
Filed: 2016-07-01
Abstract: Η παρούσα εφεύρεση σχετίζεται με συζεύγματα αντισώματος-φαρμακευτικής ουσίας (ADCs) που περιέχουν δουοκαρμυκίνη, για χρήση στη θεραπεία ανθρώπινων συμπαγών νεοπλασμάτων που εκφράζουν HER2, όπου το ανθρώπινος συμπαγές νεόπλασμα που εκφράζει HER2 είναι ενδομήτριος καρκίνος, ιδίως ορώδες καρκίνωμα μήτρας (USC). Ειδικότερα, η παρούσα εφεύρεση σχετίζεται με ADCs που περιέχουν δουοκαρμυκίνη για χρήση στη θεραπεία ενδομήτριου καρκίνου, ιδίως USC, με HER2 IHC 2+ ή 1+ και HER2 FISH αρνητική κατάσταση ιστού νεοπλάσματος.
Patent CY-1118947-T1 (CY)
Title: Ασυμμετρες ουριες και ιατρικες χρησεις αυτων
Inventor: GARCIA RUBIO SILVINA
IPC: C07D213/00
Filed: 2017-06-19
Abstract: Ενώσεις του Τύπου (I), γνωστές ως ασύμμετρες ουρίες, είναι χρήσιμες για την πρόληψη και/ή τη θεραπευτική αντιμετώπιση παθήσεων οι οποίες σχετίζονται παθοφυσιολογικά με τον υποδοχέα γκρελίνης σε ένα υποκείμενο. Μέθοδος θεραπευτικής αντιμετώπισης μιας πάθησης που προκαλείται από τον υποδοχέα γκρελίνης η οποία περιλαμβάνει τη χορήγηση στο αναφερθέν υποκείμενο μιας θεραπευτικά δραστικής ποσότητας μιας ένωσης του Τύπου (I) ή ενός φαρμακευτικά αποδεκτού άλατος ή ένωσης προσθήκης αυτής. Φαρμακευτικές συνθέσεις για την πρόληψη και/ή τη θεραπευτική αντιμετώπιση παθήσεων οι οποίες σχετίζονται παθοφυσιολογικά με υποδοχέα γκρελίνης σε ένα υποκείμενο, οι οποίες περιλαμβάνουν μια θεραπευτικά δραστική ποσότητα μιας ένωσης του Τύπου (I) ή ενός φαρμακευτικά αποδεκτού άλατος ή ένωσης προσθήκης αυτής και ενός ή περισσοτέρων φαρμακευτικά αποδεκτών εκδόχων.
Patent CY-1119627-T1 (CY)
Title: Κυλινδρος υμενιου υποβληθεις σε στοχαστικη επεξεργασια laser
Inventor: MACFARLANE GRAHAM
IPC: B41N7/06
Filed: 2017-11-28
Abstract: Κύλινδρος υμενίου για την εκτύπωση offset με επιφάνεια με υψώματα και βαθουλώματα, χαρακτηριζόμενος από το ότι τα υψώματα και βαθουλώματα σχηματίζουν ακανόνιστο τυχαίο σχέδιο.
Patent CY-1122981-T1 (CY)
Title: Συνθεσεις για διαμορφωση της εκφρασης του c9orf72
Inventor: RIGO FRANK
IPC: C12N15/113
Filed: 2020-06-02
Abstract: Αποκαλύπτονται στο παρόν συνθέσεις και μέθοδοι για τη μείωση της έκφρασης των C9ORF72 mRNA και πρωτεΐνης σε ένα ζώο. Τέτοιες μέθοδοι είναι χρήσιμες για τη θεραπεία, πρόληψη, βελτίωση, ή βραδεία πρόοδο νευροεκφυλιστικών ασθενειών σε ένα άτομο που έχει ανάγκη αυτών.
Patent CY-1123715-T1 (CY)
Title: Ινα απο συνθετικη yλh me ηλεκτρικη αγωγιμοτητα
Inventor: VAN HATTUM EDGAR JOHANNES
IPC: H01B1/22
Filed: 2021-01-05
Abstract: Η ίνα αποτελείται από συνθετική ύλη και διαθέτει μια ηλεκτρική αγωγιμότητα. Το υλικό της ίνας διαμορφώνεται από ένα υλικό βάσης από PET. Στο υλικό βάσης υπάρχουν αποθηκευμένα στοιχεία. Τα στοιχεία περιλαμβάνουν μια ατομική διάσταση και επικαλύπτονται τουλάχιστον ανά περιοχές με τα ηλεκτρικά τους σύννεφα.
Patent HR-P20110547-T1 (HR)
Title: Strontium-82/rubidium-82 generator, method for producing a rubidium-82 comprising diagnostic agent, said diagnostic agent and its use in medicine
Inventor: CLAESSENS ROLAND ANTHONIUS MARIA JOHANNE
IPC: G21G4/08
Filed: 2011-07-25
Abstract: The invention relates to a strontium-82/rubidium-82 generator, comprising a column filled with a cationic exchanger loaded with strontium-82, and having an inlet and an outlet, and a liquid medium, wherein parts of the column, inlet and outlet coming into contact with the liquid medium are iron-free, preferably metal-free, to a method for producing rubidium-82, and to the obtained diagnostic agent.
Patent SI-1734995-T1 (SI)
Title: Monoclonal antibodies to hepatocyte growth factor
Inventor: KIM KYUNG JIN
IPC: A61K39/00
Filed: 2004-08-13
Abstract: The present invention is directed toward a neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.
Patent SI-1757339-T1 (SI)
Title: Snowboard and ski core
Inventor: PLENK KLAUS
IPC: A63C5/00
Filed: 2005-08-27
Abstract: Snowboard or ski core (1) with a reinforcing edge (4) around it. The reinforcing edge is sprayed onto the core by a plastic injection moulding process. It is sprayed over the total thickness of the core according to the amount of headroom available. It can be sprayed over the whole extent of the core. It consists of at least two compatible plastics.
Patent SI-2353779-T1 (SI)
Title: Cutting tool holder arrangement
Inventor: PUSAVEC FRANCI
IPC: B23Q11/00
Filed: 2010-02-05
Abstract: A cutting tool holder arrangement is provided, comprising a cutting tool holder (8); a cutting tool (16); a conduit (1, 6, 13) provided through said cutting tool holder arrangement for the delivery of a cooling fluid to a cutting zone of the cutting tool (16); characterized in that a temperature sensor (7) is provided in said cutting tool holder (8) for establishing a temperature of said cooling fluid in said conduit (1, 6, 13).
Patent SI-2743348-T1 (SI)
Title: Novel anti-human ngf antibody
Inventor: KAMOHARA MASAZUMI
IPC: C12P21/00
Filed: 2012-08-10
Abstract: To provide an anti-human NGF antibody or an antigen-binding fragment thereof that is excellent in safety by reducing the risk of side effects such as effects on a fetus and thrombus formation while maintaining high neutralizing activity, and to provide means for preventing or treating various diseases in which human NGF is involved in the formation of pathological conditions, by using the antibody or the antibody-binding fragment thereof. An anti-human NGF antibody Fab′ fragment comprising a heavy-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:6 and a light-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:4.
Patent SI-3122909-T1 (SI)
Title: Method for solidifying liquid steel slag
Inventor: VAN MECHELEN DIRK
IPC: C21B3/00
Filed: 2015-03-27
Abstract: The liquid steel slag (2) is poured in at least four successive layers (6-8), comprising a lowermost layer (6), an uppermost layer (7) and at least two intermediate layers (8), in a reservoir (3) and the layers of liquid steel slag are allowed to solidify. After having applied the uppermost layer (7), the solidified steel slag is cooled down more quickly by means of water. The average temperature of each of the intermediate layers (8) is kept at least until the start of the water cooling step, and this for at least one hour, above a minimum temperature which is equal to or higher than the temperature at which β-dicalcium silicate is formed. In this way, more crystalline phases different from dicalcium silicates are formed so that the formation of fines by the transition of β into γ-dicalcium silicates can be considerably reduced. A glassy material and/or a phosphorus containing compound is preferably added to the liquid slag to further reduce the formation of fines.
Patent TR-200806709-T1 (TR)
Inventor: ERDIN A ZEKI
IPC: H04N7/14
Filed: 2007-11-05
Abstract: A method for providing a videoconferencing service between two fourth generation wireless terminal types including cellular or wireless mobile and fixed terminals, said fixed terminals to include television receivers with a 4G wireless interface, each terminal employing a video camera, a microphone and loudspeaker. All terminal types will be rendered parametrically compatible by use of subscriber tables which identify called terminal parameters and which contain a class of service sequence which identifies the originating terminal's parameters wherein said class of service sequence is sent to the receiving terminal in an alternate caller ID along with selection characters which cause direct routing to the receiving terminal. The called subscriber may opt out of a video send mode by sending a “canned” video frame advising the caller that video is not available.
Patent TR-201801772-T1 (TR)
Title: Bir Aşırı Yük Emniyet Cihazı İçeren Kırıcı Cihaz
Inventor: ANDRZEJ NIKLEWSKI
IPC: B02C2/06
Filed: 2016-08-19
Abstract: Bir konik veya döner kırıcı gibi bir kırıcı cihaz olup, özelliği; bu kırıcı cihazın: uzunluğuna paralel olan bir birinci yön tanımlayan bir mil içermesi, bu milin bir üst mil ucu içermesi; bir kırıcı başlık içermesi; ve kırıcı başlığı üst mil ucu ile birleştiren bir aşırı yük emniyet cihazı içermesi, aşırı yük emniyet cihazının, kırıcı başlığı, üst mil ucundan uzağa, birinci yöne doğru yönlendirecek şekilde yapılandırılan bir yönlendirme cihazı içermesi, içerisinde: aşırı yük emniyet cihazının, kırıcı başlık üzerinde birinci yönde etki eden bir kuvvete yanıt olarak mile göre birinci yön boyunca kırıcı başlığın yer değiştirmesine olanak tanıyacak şekilde yapılandırılmasıdır.
Patent DE-3750878-T2 (DE)
Inventor: DORMAN FRANK
IPC: A61M37/00
Filed: 1987-02-02
Granted: 1995-05-11
Abstract: An implantable infusion pump (20) for infusing drugs or other chemicals or solutions into the body. A flexible spring diaphragm (25) forms an outer back wall portion (26) of a housing (22) of the infusion pump (20). The spring diaphragm (25) applies substantially constant force over a range of displacement and communicating internal body pressure to the drug chamber (30) so as to maintain a substantially uniform pressure difference between the drug chamber (30) and the internal body pressure.
Patent DE-3784327-T2 (DE)
Inventor: YOSHIMATSU HIROSHI
IPC: G11B7/09
Filed: 1987-12-15
Granted: 1993-09-09
Abstract: An optical pick-up apparatus comprises a light beam generating source (2), an objective lens (5) for causing a light beam from the light beam generating source (2) to impinge upon a record medium (6) and receiving a reflected light beam from the record medium (6), a composite prism (21) constituted by a glass prism element (22), a crystal prism element (23) and a multi-layer (21a) of dielectric material provided between the glass and crystal prism elements (22, 23) which are bonded together, and so disposed that the light beam from the beam generating source (2) and the reflected light beam from the objective lens (5) enter into the glass prism element (22) through respective different optical paths, the light beam from the beam generating source (2) is directed to the objective lens (5) after passing through the glass prism element (22) and at least two light beams obtained based on the reflected light beam from the objective lens (5) emerge from the crystal prism element(23), and a photodetecting unit (26) for detecting separately the light beams emerging from the crystal prism element (23) of the composite prism (21).
Patent DE-3786460-T2 (DE)
Inventor: MALEK CHARLES
IPC: H04L9/00
Filed: 1987-06-30
Granted: 1993-10-21
Abstract: A Gateway apparatus and method is disclosed which permits secure, end-to-end communications to exchange automatically between predetermined authorized subscribers operating on a radio network and a telephone network. The Gateway determines whether clear or coded message signals are to be routed from one network to another without utilizing an intervening decryption and encryption to accomplish the interconnection. The Gateway includes a radio network interface, a telephone network interface, a signal processor, and a supervisory controller. A Remote Interface at the location of the predetermined telephone subscriber is utilized to adapt a conventional telephone for clear and coded modes of operation. Moreover, an alternate embodiment is disclosed which permits two radio networks to be interconnected via the telephone network by utilizing two Gateways.
Patent TR-199801667-T2 (TR)
Inventor: DAURON FRANCOIS
IPC: F24D13/02
Filed: 1997-02-25
Abstract: Beton gibi bir malzemenin barindirilmasi veya depolama ve nakliye gayesi ile yan panolarin katlanmis bir vaziyette tutulmasi için bir bosluk tayin edecek sekilde yan panolarin  (3) birbirinden bir mesafede  tutulmasina yönelik eklemli baglanti komponentleri ile baglanan ve birbirine bakan iki döküm panosu (3) ihtiva eden kalip . Eklemli baglanti komponentleri hemen hemen  zig- zagli bir biçimde katlanan/ kivrilan uzunlamasina komponentlerden (7A) tesekkül eder, ve katlanmis/ kivrilmis her uzunlamasina  komponent karsit bir vaziyette bulunan açili takviye çubuklari (4A) ile baglanan karsit kisimlar (6) içerir ve takviye çubuklari da sözü geçen karsit kisimlarin (6) her bir yaninda yer alir.
Patent TR-199801717-T2 (TR)
Inventor: JARVENKYLA JYRI
IPC: B29C48/94
Filed: 1997-03-19
Abstract: A method for manufacturing an extrudable product including the steps of (a) providing an apparatus including an extruder having at least one rotor with first grooves, at least one stator with second grooves and a clearance between the rotor and the stator, the first grooves, second grooves and clearance forming a processing cavity having a volume that is equal to the volumes of the first grooves, the second grooves and the clearance, the processing cavity having a cross-sectional area that decreases continuously along at least a part of an axis of the extruder, the extruder further having a supply for feeding a material to be extruded into the processing cavity; b) feeding the material to be extruded in a powder, pellet or granuate form into the processing cavity through the supply and causing rotation of the rotor relative to the stator such that the material is forced to proceed along an x-axis in a shear zone of the extruder where the material is subjected to a shear which causes a fictional heat that melts a part of the material and forms a bed of mainly unmelted particles and melt around the particles, the processing cavity being completely filled at a cross-sectional portion thereof that is a distance from the end of the extruder, the unmelted particles being present in the cross-sectional portion in an amount sufficient to increase a pressure in the extruder to a level that is higher than that needed for pushing the material further along the x-axis to a die.
Patent DE-60004904-T2 (DE)
Inventor: MARRITT A
IPC: C08B37/04
Filed: 2000-02-24
Granted: 2004-03-11
Abstract: The present invention relates to a method for the manufacture of polyguluronic acids having a degree of polymerization of less than 20 and being substantially free of mannuronic acid contamination which can be carried out on an industrial scale. <IMAGE>
Patent DE-60008425-T2 (DE)
Inventor: BRAITHWAITE PHILIP
IPC: C08G61/02
Filed: 2000-10-11
Granted: 2004-12-02
Abstract: There is described a reservoir means which means is provided with a moisture resistant coating, the reservoir means is especially adapted to contain a medicament. There is also described a medicament delivery device which comprises a medicament reservoir, a medicament delivery passage and a metering member characterised in that the device includes a surface or surfaces provided with a moisture resistant coating. The device is especially an inhaler, e.g. a dry powder inhaler. A method of treating a respiratory disorder is also described which comprises administering of a therapeutically effective amount of a pharmaceutically active agent to a patient suffering from such a disorder.
Patent DE-60009890-T2 (DE)
Inventor: HOAD LESLIE
IPC: C08J9/12
Filed: 2000-05-05
Granted: 2005-04-07
Abstract: A method of producing a bituminous foam includes supplying a bitumen in water emulsion from a tank (2) into primary and secondary heating circuits (8, 34), whereby the emulsion is heated (via heating coils 12 and 12') and its pressure raised such that, on discharge to ambient conditions via outlet pipes (30 or 30'), the emulsion foams as water evaporates therefrom.
Patent DE-60013591-T2 (DE)
Inventor: NOLL O
IPC: C07K14/47
Filed: 2000-04-28
Granted: 2005-02-03
Abstract: Synthetic single-stranded oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides in specific base contexts or T-rich motifs, including poly T, (immunostimulatory ODNs) are immunostimulatory for B lymphocytes and other lymphoid and nonlymphoid cells, while ODN without these CpG sequences or T-rich motifs (non-immunostimulatory ODNs) are not. Mechanisms by which cells discriminate between immunostimulatory and non-immunostimulatory ODNs are hitherto unknown. The invention is based upon the purification and identification of immunostimulatory DNA binding proteins, naturally occurring cellular proteins which bind specifically to immunostimulatory ODNs and mediate the observed immunostimulatory effects. These proteins are RNA binding proteins and include nucleolin, hnRNP A1, hnRNP D, AUF1, and lupus La protein. The invention provides methods for the use of RNA binding proteins as immunostimulatory DNA binding proteins. Provided are methods useful for screening and identifying immunostimulatory DNA inhibitors, competitors, agonists, mimics, and cellular targets. Methods are also provided for using immunostimulatory DNA binding proteins to optimize immunostimulatory ODN for immune stimulation. Also provided are an isolated immunostimulatory ODN-immunostimulatory DNA binding protein complex and a kit for identifying cellular targets of immunostimulatory DNA.
Patent DE-60016243-T2 (DE)
Inventor: BOND ANTHONY
IPC: F16L55/46
Filed: 2000-09-07
Granted: 2005-12-01
Abstract: A method and apparatus for detecting and/or locating leaks in a pipe 12. The method comprises moving two acoustic sensors 502,504 along the pipe 12, generating signals corresponding to acoustic signals received by each of said acoustic sensors 502,504, and transmitting the generated signals from each of the acoustic sensors 502,504 to a respective loudspeaker.
Patent DE-60017878-T2 (DE)
Inventor: DAVIS PETER DAVID
IPC: A61P3/10
Filed: 2000-02-15
Granted: 2006-01-26
Abstract: Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or action of nitric oxide in mammalian systems. There are also provided the use of said combinations in medicaments and kits of said compounds and treatment employing said materials.
Patent DE-60022300-T2 (DE)
Inventor: ALLEN WILLIAM PATRICK
IPC: F01D5/28
Filed: 2000-12-12
Granted: 2006-06-22
Abstract: A turbine blade has an airfoil 12, a root 14 and a platform 16 located between the airfoil 12 and root 14. The platform 16 has an underside adjacent the root, and a corrosion resistant overlay coating (21;24) such as an MCrAIY or a noble metal containing aluminide or corrosion inhibiting ceramic is located on portions or the blade not previously covered with such coatings, e.g., the underside of the platform and the neck 19. The applied coating prevents corrosion and stress corrosion cracking of blade in these regions. Where the airfoil is also coated, the airfoil coating may have a composition different from that of the coating on the underplatform surfaces. <IMAGE>
Patent DE-60025129-T2 (DE)
Inventor: MODI SOHRAB F
IPC: H04L29/08
Filed: 2000-10-18
Granted: 2006-08-17
Abstract: One embodiment of the present invention provides a system that uses a packet distribution table to distribute packets to server nodes in a cluster of nodes that operate in concert to provide at least one service. The system operates by receiving a packet at an interface node in the cluster of nodes. This packet includes a source address specifying a location of a client that the packet originated from, and a destination address specifying a service provided by the cluster of nodes (and possibly a protocol). The system uses the destination address to lookup a packet distribution table. The system then performs a function that maps the source address to an entry in the packet distribution table, and retrieves an identifier specifying a server node from the entry in the packet distribution table. Next, the system forwards the packet to the server node specified by the identifier so that the server node can perform a service for the client. In this way, packets directed to a service specified by a single destination address are distributed across multiple server nodes in a manner specified by the packet distribution table. In one embodiment of the present invention, the system allows the server node to send return communications directly back to the client without forwarding the communications through the interface node. In one embodiment of the present invention, the function includes a hash function that maps different source addresses to different entries in the packet distribution table in a substantially random manner. Note that this hash function always maps a given source address to the same entry in the packet distribution table. <IMAGE>
Patent DE-60033646-T2 (DE)
Inventor: NITSCH ROGER
IPC: G01N33/53
Filed: 2000-05-02
Granted: 2007-11-29
Abstract: A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, involves determining a level, or an activity, or both the level and the activity, of nerve growth factor in a sample taken from cerebrospinal fluid of the subject, and comparing the level, or the activity, or both the level and the activity, to a reference value representing a known disease or health status, wherein a varied level, or activity, or both the level and the activity, of nerve growth factor in the cerebrospinal fluid from the subject relative to the reference value representing a known health status indicates a diagnosis, or prognosis, or increased risk of the Alzheimer's disease in the subject.
Patent DE-60100666-T2 (DE)
Inventor: SHOA A ABDUL RAHMAN
IPC: A61K47/22
Filed: 2001-02-22
Granted: 2004-06-24
Abstract: Micellar non-aqueous or aqueous compositions for the therapeutic treatment of animal diseases caused by parasitic worms or nematodes, comprising rafoxanide and specific combinations of solvents which act as stabilizing and absorption-promoting agents. The solvents are selected from non-ionic surface active agents such as Tween-80 and from N-methylpyrrolidone, 2-pyrrolidone or dimethylsulfoxide. The compositions are easy to prepare, stable upon storage and can be administered orally, by injection or topically. With these formulations, an improvement of the efficacy of rafoxanide in the treatment of the diseases is observed.