baber/WOPTO huggingface dataset:
Patent IL-67602-A0 (IL)
Title: N-oxide compounds,process for their manufacture and pharmaceutical compositions containing them
IPC: C07D213/89
Filed: 1982-12-31
Abstract: The present invention relates to novel N-oxide compounds that have cardiovascular properties, especially antihypertensive activity, and that correspond to the formula    <IMAGE>  (I)  in which Py represents an unsubstituted or substituted N-oxidopyridyl radical, R1 represents hydrogen or unsubstituted or substituted lower alkyl, one of the radicals R2 and R3 represents lower alkyl and the other represents hydrogen; lower alkyl; lower alkyl containing free, etherified or esterified hydroxy, oxo, functionally modified carboxy or free or substituted amino or imino; functionally modified carboxy; or free or substituted amino, it being possible for an amino group R2 or R3 to be bonded to a lower alkyl radical R1 or, if R2 or R3 represents, for example, hydroxy-lower alkyl, for this hydroxy-lower alkyl, together with the adjacent acyl radical Ac1 or Ac2, to form a 2-oxa-1-oxo-lower alkylene radical, the carbonyl group of which is bonded to the 3- or 5-ring carbon atom of the 1,4-dihydropyridine ring, and each of the groups Ac1 and Ac2  represents, independently of the other, the acyl radical of an acid, and salts of compounds of the formula I having salt-forming groups, processes for the manufacture of these compounds, the use of these compounds and their salts, and pharmaceutical preparations which contain these compounds and salts, as antihypertensive agents and coronary dilators for the treatment of cardiovascular conditions, such as hypertonia, vascular constrictions, Angina pectoris and cardiac insufficiency.
Patent IL-81544-A0 (IL)
Title: Two piece combination boat and luggage carrier
IPC: B63B7/04
Filed: 1987-02-12
Abstract: A combination two-section boat and cargo carrier comprises first and second substantially identical sections (10, 12), each having a substantially horizontal bottom surface (14), at least two generally vertical sidewalls (16, 18) and a generally vertical connecting wall (22). The connecting wall is configured with a male connector (62a, 62b), which protrudes from the surface of the connecting wall in a direction generally normal to the plane of the connecting wall, and a complementary female connector (64a, 64b) which is recessed into the connecting wall in a direction generally normal to the plane of the connecting wall. The male and female connectors are symmetrically disposed from a vertical centre line of the connecting wall and are adapted to mate with each other when the connecting walls of the first and second identical sections are placed in abutting relation to one another. A removable assembly blade connector (68) is provided in order to join the male nad female connectors, so as to form a boat. When superposed, the sections provide a water-right cargo carrier which is secured by removable clamps (38) which engage the upper protruding edges of the sections.
Patent IL-82945-A0 (IL)
Title: Pyridineethanolamine derivatives,their manufacture and pharmaceutical compositions containing them
IPC: C07D409/12
Filed: 1987-06-22
Abstract: Pyridine-ethanolamines of the formula    <IMAGE>  I  wherein n, X, Y, R1, R2 and R3 have the significances given in the description, their corresponding enantiomers, diastereomers, and racemates as well as the pysiologically compatible salts thereof are describe. The compounds of formula I have catabolic activity and can be used for the treatment of obesity and of diabetes mellitus or of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals. The compounds of formula I can be prepared by alkylating the primary or secondary amines corresponding to the secondary or tertiary amines of formula I.
Patent IL-87144-A0 (IL)
Title: Pharmaceutical composition containing quinoline and naphthyridine carboxylic acids
IPC: A61K31/65
Filed: 1988-07-18
Abstract: The invention relates to a synergistic, anti-microbial pharmaceutical composition containing 0.01 to 50 % by weight of a quinolinecarboxylic acid derivative or a naphthyridinecarboxylic acid derivative of the general formula (I), <CHEM>  wherein  X is carbon or nitrogen;  R<1> is hydrogen or fluorine;  R<2> is methyl, piperazino or methylpiperazino group; or R<1> and R<2> together are a methylenedioxy group; and 0.01 to 95 % by weight of a tetracycline derivative of the general formula (II), <CHEM>  wherein  R<3> and R<4> are hydrogen; or  R<3> and R<4> together represent an additional chemical bond, in an 1:1 to 1:20 ratio of the compound of the general formula (I) to the compound of the general formula (II), optionally in an admixture with an amount required to 100 % by weight of an inert, solid or liquid carrier such as magnesium carbonate, magnesium stearate, starch, talc, cyclodextrine or water and other additives such as filling, disintegrating, sliding and emulsifying agents.
Patent IL-90845-A0 (IL)
Title: Process and intermediates for the synthesis of optically active aminoacids
IPC: C07C227/34
Filed: 1989-07-03
Abstract: New process for the synthesis of optically active aminoacids of formula <CHEM> wherein R and R1, equal or different,represent a hydrogen atom or an alkyl radical, straight or branched, containing from 1 to 6 carbon atoms, by reacting compounds of formula <CHEM> wherein R and R1 have the above seen meanings, R2 represent a nitrile group or a COR4 group wherein R4 represents hydroxy or halogen or alkoxy, straight or branched,containing from 1 to 6 carbon atoms,or a OCOR5 wherein R5 represents an alkyl or an alkoxy group, straight or branched, containing from 1 to 6 carbon atoms and R3 represents hydrogen, an alkyl or an alkoxy radical, straight or branched, containing from 1 to 6 carbon atoms or an aryl or aralkyl radical, with an optically active alcohol of formula  R6-OH      (III)  d or l wherein R6 represents an alkyl or cycloalkyl group, substituted or unsubstituted, containing from 3 to 12 carbon atoms, to obtain a pair of diastereoisomer esters of formula <CHEM> which is resolved in basic medium into the single diastereoisomer esters of formula <CHEM> from which the desired optically active aminoacid of formula (I) is obtained by treatment in acid medium.
Patent AU-PN531195-A0 (AU)
Title: Lipid extract having anti-inflamatory activity
IPC: A61K35/56
Filed: 1995-09-11
Abstract: PCT No. PCT/AU96/00564 Sec. 371 Date May 5, 1998 Sec. 102(e) Date May 5, 1998 PCT Filed Sep. 10, 1996 PCT Pub. No. WO97/09992 PCT Pub. Date Mar. 20, 1997Anti-inflammatory, and particularly anti-arthritic, treatment of a human or animal patient comprises administration to the patient of an effective amount of a lipid extract of Perna canaliculus or Mytilus edulis.
Patent AU-PP852699-A0 (AU)
Title: Strip casting apparatus
IPC: B22D11/16
Filed: 1999-02-05
Abstract: Twin roll strip caster comprising parallel casting rolls (16) one of which is mounted on moveable roll supports (104) which allow it to move bodily toward and away from the other roll (16). A pair of roll biasing units (110) comprising compression act on roll supports (104) to bias the moving roll (16) toward the other roll. Biasing units (110) comprise compression springs (112) acting on roll supports (104) through thrust transmission structures (122) and thrust reaction structures (121). The positions of thrust reaction structures (121) are set by hydraulic cylinder units (119) operable vary the position of each reaction structure (121) to replicate movements of the respective thrust transmission structure 122 so as to maintain a constant compression of the biasing springs (112) regardless of lateral movements of the roll supports (104).
Patent FI-20010392-A0 (FI)
Inventor: JAEMSAE TOMMI
IPC: H04B17/00
Filed: 2001-02-27
Abstract: The invention relates to a method of performing channel simulation on a radio frequency signal and to a channel simulator for implementing the method. In the solution, the total band reserved for the signal to be applied to channel simulator units is divided into at least two sub-bands. Channel simulation is performed on signals corresponding to each sub-band in the channel simulator units. Finally, the signals simulated in the different sub-bands are combined to form a total band signal in a combiner after channel simulation.
Patent FI-20020763-A0 (FI)
Inventor: SILLANPAEAE TERO
IPC: H03K5/24
Filed: 2002-04-19
Abstract: A comparator circuit comprises an input stage (1) including a pair of inputs for receiving a differential input voltage and a pair of outputs for outputting a differential output current proportional to the differential input voltage. The differential output current is amplified by a transistor output stage (2). According to the present invention a voltage swing at the internal node(s) of a transistor output stage in a comparator is limited (M7,M8). As a result, the comparator response time is reduced and independent from the variation in the supply voltage. <IMAGE>
Patent FI-20116007-A0 (FI)
Inventor: MAEYRAE-MAEKINEN ANNIKA
IPC: A61K35/745
Filed: 2011-10-12
Abstract: The invention is based on a correlation observed between serotonin level and intestinal flora. The invention relates to a relative proportion of bifidobacteria in the intestine and in particular to a product increasing the ratio of bifidobacteria to Clostridia, to be used for raising the serotonin level. The invention also relates to a method for estimating a health risk associated with serotonin depletion by determining a relative proportion between bifidobacteria or Clostridia in the intestine or their ratio to one another. The invention further relates to a method for selecting a form of therapy for raising the serotonin level by determining a relative proportion between bifidobacteria or Clostridia in the intestine or their ratio to one another.
Patent IL-103802-A0 (IL)
Title: System for energy storage,hydrogen production and the manufacture of methanol for abating greenhouse gases
IPC: C07C31/04
Filed: 1992-11-19
Abstract: A method for the joint i) abatement of emission of a "greenhouse" gas by removing carbon dioxide from an effluent and ii) manufacture of methanol by reaction of hydrogen with carbon dioxide which includes: a) reacting carbon dioxide in the effluent by flowing contact of the effluent with a bed of basic metal oxide at a temperature suitable to form a metal carbonate, b) then stopping the effluent flow after said bed has become substantially converted to the carbonate, c) heating the carbonate to a temperature suitable to release carbon dioxide, d) then mixing the released carbon dioxide with hydrogen while passing the mixture over a catalyst of another metal oxide at a suitable temperature and pressure for a reaction, and thereby forming methanol.
Patent IL-105909-A0 (IL)
Title: Fungicidal compositions comprising indole derivatives,certain such novel compounds and their preparation
IPC: C07D413/06
Filed: 1993-06-04
Abstract: The invention relates to fungicidal compositions which comprise a carrier and, as active ingredient, an indole derivative of the formula   <IMAGE>   in which R is a substituted phenyl group; R3 and R4 independently are hydrogen or halogen or an optionally substituted alkyl, alkoxy, cycloalkyl, phenyl or phenoxy group; R5 and R6 independently are hydrogen atom or an optionally substituted alkyl, alkoxy, cycloalkyl, phenyl or heterocyclyl group or R5 and R6 together with the interjacent nitrogen atom represent a heterocyclyl group; and R7 is hydrogen or alkyl group; and their use as fungicides. Certain of the above mentioned indole derivatives are novel and a process for the preparation of these compounds is also provided.
Patent IL-108289-A0 (IL)
Title: Thiazolidine derivatives, their preparation and medicaments containing them
IPC: C07K5/06
Filed: 1994-01-06
Abstract: PCT No. PCT/FR94/00007 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Jan. 3, 1994 PCT Pub. No. WO94/15955 PCT Pub. Date Jul. 21, 1994Derivatives of formula (I), their salts, the preparation of said derivatives and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for cholecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract    <IMAGE>  (I)
Patent IL-112112-A0 (IL)
Title: Peptide derivatives and pharmaceutical compositions containing them
IPC: A61P5/10
Filed: 1994-12-22
Abstract: PCT No. PCT/DK94/00485 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Dec. 22, 1994 PCT Pub. No. WO95/17423 PCT Pub. Date Jun. 29, 1995Compounds of the formula A-B-C-D(-E)p are used to stimulate the release of growth hormone from the pituitary.
Patent IL-112962-A0 (IL)
Title: Retroviral protease inhibiting compounds
IPC: C07C317/10
Filed: 1995-03-12
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed. <CHEM>
Patent IL-123411-A0 (IL)
Title: High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm
IPC: C07K14/435
Filed: 1998-02-22
Abstract: The present invention relates to high efficiency methods and compositions for stably integrating exogenous double-stranded DNA into the chromosomal DNA of sperm cells. The exogenous DNA to be integrated into the sperm is converted to a linear double stranded DNA possessing single-stranded cohesive ends, by contacting said exogenous DNA with a type II restriction enzyme that upon scission, generates such ends. The DNA to be cut can be a circular DNA such as in a plasmid, such that it possesses at least one recognition and cutting site outside of the genes or regulatory regions critical to the desired, post-integration function of the DNA, and no recognition and cutting sites within the critical regions. The exogenous DNA is then introduced into sperm cells, as is some of the type II restriction enzyme used above to generate the single-stranded cohesive ends on the exogenous DNA. The DNA and the corresponding restriction enzyme can be introduced into the sperm cells, together or sequentially, by electroporation or lipofection or by any other technique that preserves enough of said sperm's mobility and fertilization functions. The sperm containing the integrated exogenous DNA can then be used to fertilize eggs by artificial insemination, in vitro fertilization, or other fertilization methods known in the art, thereby producing transgenic animals wherein all or a plurality of cells now contain the exogenous DNA stably integrated into their respective genomes. The present invention also relates to transgenic animals or their descendants produced by methods or compositions herein disclosed. The present invention further relates to cells or cell lines derived from transgenic animals or their descendants produced by methods or compositions herein disclosed. The present invention further relates to proteins or other gene products encoded for by the exogenously introduced DNA isolated from said transgenic animals or their descendants. The present invention further relates to using the method of the present invention to produce transgenic animals resistant to diseases, and to the disease-resistant animals thereby produced.
Patent IL-143213-A0 (IL)
Title: Interface patch clamping
IPC: C12M1/34
Filed: 1999-12-06
Abstract: The invention provides a novel development of the conventional patch clamp technique for measurement of whole cell electrical activity. The invention provides for one or more cell or cells to be suspended in a liquid medium at a liquid/air interface (by virtue of the effect of surface tension at the interface) whereby the cell or cells are accessible at the interface to a microstructure electrode (such as a pipette tip) to which a cell can attach to form an electrical seal, for the purpose of whole cell voltage clamp recording. According to the invention the electrode can be caused to form a high resistance electrical seal with a cell suspended in the liquid at the liquid/air interface without the need to press the cell against a solid support surface. The invention also provides apparatus for carrying out the interface patch clamp technique and control logic for operating a computer to carry out the interface patch clamp technique.
Patent IL-149416-A0 (IL)
Title: Human enzymes of the metalloprotease family
IPC: A61P25/04
Filed: 2000-11-17
Abstract: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, to antibodies specific to such peptides, and to production of such polypeptides and polynucleotides.
Patent IL-149502-A0 (IL)
Title: Method for producing o-chloromethyl benzenecarbonyl chlorides
IPC: C07B61/00
Filed: 2000-11-27
Abstract: The invention relates to a method for producing o-choromethyl benzenecarbonyl chlorides of formula (I), wherein R<1>-R<4 >can be the same or different and stand for hydrogen, C1-C4-alkyl, halogen or trifluoromnethyl, by converting benzocondensed lactones of formula (II), wherein R<1>-R<4 >have the aforementioned meaning, with gaseous or liquid phosgene and the dimers or trimers thereof. The inventive method is characterized in that the conversion is carried out in the presence of catalytical amounts of a Lewis acid and catalytical amounts of a phosgenation catalyst
Patent IL-150707-A0 (IL)
Title: Recombinant production of human histone-1 subtypes and use thereof for therapeutic purposes
IPC: C07K14/47
Filed: 2001-01-11
Abstract: Recombinant human protein (I), having the biological activity of a histone 1 (H1), or its active fragments, produced in prokaryotic cells, especially Escherichia coli. An independent claim is also included for producing (I). - ACTIVITY : Anticancer; cytostatic; antibiotic; immunomodulatory; endocrinological; antibacterial; antiviral; antifungal; antiparasitic. When tested at 62 Microg/ml against K562 leukemia cells, recombinant histone H1.2 caused 63% cell death after 1 hour, but only 13% death of peripheral blood mononuclear cells. - MECHANISM OF ACTION : Histones are involved in organization of the chromatid structure and in gene repression. They create channels in cell membranes, increasing the permeability and leading to swelling and lysis.
Patent IL-159600-A0 (IL)
Title: Modular marine structures
Inventor: KENT ELIYAHU
IPC: E04B1/19
Filed: 2002-06-27
Abstract: A load-carrying modular structure assembled from 3-D structural modules constituting parallelepipeds with rectangular faces, the 3-D modules adjoining each other along said faces. The modules comprise reinforcing diagonal beams (RDBs) disposed along diagonals that connect vertices of the parallelepipeds. The RDBs form a 3-D multi-tetrahedron lattice whereby said modular structure behaves under load as a multi-tetrahedron structure. A basic 3-D module for assembling the modular structure has six RDBs along facial diagonals forming a tetrahedron. The 3-D module may have RDBs also along the other six diagonals and along diagonals connecting centers of the box's faces. The 3-D modules may have cut-outs and passages for water currents. They may have internal hollow volumes and controlled buoyancy, and may be assembled from shell elements.
Patent IL-160105-A0 (IL)
Title: Vaccine for treatment of motor neurone diseases
IPC: A61P25/00
Filed: 2002-12-05
Abstract: A vaccine for reducing disease progression, and/or protection of motor nerve degeneration, and/or protection from glutamate toxicity in motor neurone disease (MND), particularly amyotrophic lateral sclerosis (ALS), patients, comprising an active agent selected from the group consisting of Cop 1, a Cop 1-related peptide, a Cop 1-related polypeptide, and poly-Glu, Tyr. The active agent is preferably Cop 1 or poly-Glu, Tyr, and can be administered with or without an adjuvant.
Patent IL-160931-A0 (IL)
Title: Powder processing with pressurized gaseous fluids
IPC: A61J3/06
Filed: 2002-10-10
Abstract: Disclosed is a method of small particle precipitation, retention and dispersion of a solid or semi-solid material onto or into a carrier material. In this method, solute particles are precipitated from a pressurized gaseous fluid solution or a liquid solution and effectively retained and dispersed within a carrier material. This technique can be advantageously used in pharmaceutical processing to produce a blend of solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof.
Patent IL-164696-A0 (IL)
Title: Lancing device with a floating probe for control of peneteration depth
IPC: A61B5/15
Filed: 2004-10-19
Abstract: A lancing device (100) includes a lancing mechanism (106), a floating probe (108) and a pressure tip (104). The lancing mechanism includes a lancet carriage (114), a lancet holder (116) slidably connected to the lancet carriage, and a lancet (118) attached to the lancet holder. The pressure tip of the lancing device is configured for engaging a target site and creating a target site bulge. The floating probe is adapted to floatably contact the target site bulge and to operatively interact with the lance carriage to control a penetration depth of the lancet into the target site bulge. A method for lancing a target site includes providing the lancing device describe above and contacting the pressure tip of the lancing device with the target site. The pressure tip is then urged towards the target site to create a target site bulge with the floating probe of the lancing device floating on a surface of the target site bulge. Next, the target site bulge is lanced while the floating probe operatively interacts with the lance carriage to control a penetration depth of the lancet.
Patent IL-174360-A0 (IL)
Title: Process for the preparation of chiral propionic acid derivatives
IPC: C07D413/12
Filed: 2006-03-16
Abstract: The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as defined in the specification and claims. The compounds of formula I and the corresponding salts and/or esters are pharmaceutically active substances.
Patent IL-176452-A0 (IL)
Title: Effervescent oral opiate dosage form
IPC: A61K9/20
Filed: 2006-06-20
Abstract: Opiate containing dosage forms and methods using same are described. These dosage forms include substantially less opiates by weight than known oral formulations. These dosage forms are intended for oral administration across the oral mucosa.
Patent IL-176470-A0 (IL)
Title: Crystal form of quinoline compound and process for its production
IPC: A61K31/47
Filed: 2006-06-21
Abstract: A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1):The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.