baber/WOPTO huggingface dataset:
Patent PT-1032379-E (PT)
Inventor: RIEDLL JUTTA
IPC: A61K47/00
Filed: 1998-11-18
Abstract: The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.
Patent PT-1074621-E (PT)
Title: Human tsc403 gene
Inventor: HORIE MASATO
IPC: A61K38/00
Filed: 1999-02-02
Abstract: This invention provides the TSC403 gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, which is a novel gene of great utility particularly in the field of research, diagnosis, therapy, etc. for cancer of the lung, among other diseases.  In addition, this invention provides the human ING1L gene comprising a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:4, which is a novel human gene useful for regulating the cell cycle, inhibiting or activating cell proliferation, studies on metabolic aging or apoptosis of cells, pathological exploration, diagnosis and therapy of cancer and other diseases, and screening for the development of new drugs.
Patent PT-1109813-E (PT)
Inventor: ADAMS DAVID REGINALD
IPC: C07D487/04
Filed: 1999-09-01
Abstract: A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity
Patent SG-984-G (SG)
Title: Electronic tone generator
IPC: G10H7/00
Filed: 1984-01-03
Abstract: An electronic tone or note generator capable of providing improved musical and tone quality and special sound effects by mixing the outputs of a plurality of note-signal-producing circuits is provided. The electronic tone or note generator of the invention is characterized by the use of a primary electronic note circuit for producing a primary note signal which is a portion of a primary melody, and a secondary electronic note circuit for producing a secondary note signal that is musically related to the primary melody. The relationship between signals can be a time lag between the outputs of the two note signal circuits or a small difference in frequency between the signal outputs of the two note circuits. Additionally, each note signal circuit can output alternate notes of a continuing melody such that a note from one circuit may persist while the next note from the second circuit is played. The note signals from the note-producing circuits are shaped and mixed or summed and then applied to an electroacoustic transducer in order to produce audible music of high sound quality. The acoustical frequency of each note and the time between initiation of successive notes are stored in memory units associated with each note-signal-producing circuit. The outputs of high-frequency signal sources are variably divided down to provide the individual note signals and control note timing.
Patent SG-83692-G (SG)
Title: Electrode supporting arm for an electric arc furnace
IPC: H05B7/103
Filed: 1992-08-21
Abstract: PCT No. PCT/EP89/00480 Sec. 371 Date Sep. 7, 1990 Sec. 102(e) Date Sep. 7, 1990 PCT Filed May 2, 1989 PCT Pub. No. WO89/11203 PCT Pub. Date Nov. 16, 1989.An electrode carrier arm for an electric arc furnace consists of an arm part (10) and of a electrode-clamping device and is produced so as to be current carrying from a material of high conductivity. Between the arm part and the electrode-clamping device there is a flanged connection consisting of flanged plates (11, 12) which limit a cooling-liquid cavity (20, 29) on both sides and which themselves contain passage orifices (21) for the cooling liquid from one cooling-liquid cavity to the other. This allows an effective cooling of the flanged plates and consequently a direct supply of current via the flanged connection when the carrier arm is produced from light metal.
Patent IE-820464-L (IE)
Title: Morpholines
IPC: A61K31/535
Filed: 1982-03-02
Abstract: Morpholine derivatives of the formula <CHEM> and their acid addition salts, wherein n represents 1, 2 or 3, R<3> is alkyl of 1 to 10 carbon atoms, R<4> is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofurylmethyl or cyclo(lower)alkylmethyl and OR<5> is hydroxy, acyloxy or a protected hydroxy group possess analgesic and/or opiate antagonistic activity or are useful as intermediates for other compounds of formula I possessing such activity.
Patent IE-830667-L (IE)
Title: Preparation of benzothiazine derivatives
IPC: C07D417/12
Filed: 1983-03-25
Abstract: The present invention provides a process for the preparation of 4-hydroxy-3-(heterocyclocarbamoyl)-2H-1,2-benzothiazine-1,1-dioxides of the general formula: <IMAGE> wherein R1 is a hydrogen atom or a methyl radical, R2 is a nitrogen-containing heterocyclic radical and R3 is a hydrogen or halogen atom or a methyl radical, and of the alkali metal, alkaline earth metal and amine salts thereof, by the reaction of an amine-substituted, nitrogen-containing heterocyclic compound with a halo-acetyl halide, reaction of the intermediate thus obtained with sodium benzoic acid sulphimide, ring expansion of the benzoisothiazole ring to give a benzothiazine ring and, in case R2 is to be an isoxazolyl radical, reverse rearrangement of the oxadiazole-ring formed by ring expansion to the isoxazolyl ring, wherein (in a one-pot reaction A) the reaction of an amine-substituted, nitrogen-containing heterocyclic compound with a halo-acetyl halide is carried out, without the addition of a base, in boiling ethyl acetate, the intermediate formed is, without isolation, reacted with sodium benzoic acid sulphimide and the reaction product isolated, whereafter, in a one-pot reaction B, the reaction product from the one-pot reaction A is reacted in a dipolar aprotonic solvent under an atmosphere of a protection gas with a strongly basic alkali-alkohole and thereafter with so much acid that about 2 equivalents of base remained unneutralized in the reaction solution and, if desired, the benzothiazine ring is N-methylated in the usual manner and the product obtained is, if desired, converted in known manner into an alkali metal, alkaline earth metal or amine salt.
[US4477661A]
Patent IE-900684-L (IE)
Title: Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and¹3-aminochromanes
IPC: C07D311/02
Filed: 1990-02-26
Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which exhibit binding activity at the serotonin 1A receptor and 3-aminochromane intermediates. The pharmaceutical compounds have the formula <CHEM>  in which R is C1-C4 alkyl, allyl, or cyclopropylmethyl; R1 is hydrogen, C1-C4 alkyl, allyl, cyclopropylmethyl, or aryl(C1-C4-alkyl);  R2 is hydrogen or methyl;  X is -CH2- or -O-; R3 is C1-C8 alkyl, aryl, substituted aryl, aryl(C1-C4-alkyl), substituted aryl(C1-C4 alkyl), or C5-C7 cycloalkyl;  n is 0, 1, or 2; and pharmaceutically acceptable acid addition salts thereof.
Patent IE-870792-L (IE)
Title: Penicillanic acid derivatives
IPC: C07D499/00
Filed: 1987-03-26
Abstract: PCT No. PCT/DK87/00030 Sec. 371 Date Nov. 24, 1987 Sec. 102(e) Date Nov. 24, 1987 PCT Filed Mar. 24, 1987 PCT Pub. No. WO87/06230 PCT Pub. Date Oct. 22, 1987.The present invention relates to a new process for the debromination and/or deiodination of 6,6-dihalo- and 6-monohalopenicillanic acids or derivatives thereof by treatment with dialkyl, trialkyl or diaralkyl phosphite, the desired compounds being obtained in good to excellent yield and in a high state of purity.
Patent IE-790853-L (IE)
Title: 4-desoxy-thiazolo £5,4-c| rifamycin derivatives
IPC: A61K31/425
Filed: 1979-08-08
Abstract: Novel 4-desoxy-thiazolo[5,4-c]rifamycin derivatives of formula I <IMAGE> wherein R stands for a group -OR1, -NR2R3 or -NHCOR4 wherein R1 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, R2 and R3 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl or R2 and R3 taken together with the adjacent nitrogen atom may represent a 5 to 7 membered heterocyclic ring and R4 is a radical selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl; R5 is hydrogen or acetyl; and a process for preparing them. The novel compounds have an antibacterial utility.
[US4212873A]
Patent IE-35439-L (IE)
Title: Labelled sulphonated polysaccharide compositions.
IPC: A61K49/00
Filed: 1971-07-06
Abstract: 1355559 Diagnostic compositions G D SEARLE & CO 5 July 1971 [6 July 1970] 31396/71 Heading A5B [Also in Division C3] A diagnostic testing composition comprises a sulphated polysaccharide, e.g. sulphated potato starch amylopectin, or the metal salt thereof, of molecular weight at least one million combined with a dyestuff, e.g. a thiazindye such as methylene blue (for endoscopic examinations) or with a radionuclide, e.g. iodine-125, iodine-131 or technetium-99m for examinations using radiation imaging devices. The compositions can be administered orally in conventional manners or parenterally.
[GB1355559A]
Patent FI-822801-L (FI)
Inventor: ALOUP JEAN-CLAUDE
IPC: A61K31/33
Filed: 1982-08-11
Abstract: New heterocyclic nitriles of the formula:    <IMAGE>  (I)  wherein (i) Het represents a heterocyclic radical of aromatic character containing one or two nitrogen atoms selected from pyrid-3-yl, pyrid-4-yl, pyridazinyl, pyrazinyl, pyrimidinyl, quinolyl, imidazolyl, naphthyridinyl, quinoxalinyl and quinazolinyl, X represents an oxygen atom and Y represents a valency bond or a methylene radical, or altenatively X represents a sulphur atom and Y represents a sulphur atom, a valency bond or a methylene radical, or (ii) Het represents the pyrid-2-yl radical, X represents an oxygen atom and Y represents a valency bond or a methylene radical, or alternatively X represents a sulphur atom and Y represents a sulphur atom or a methylene radical, are useful, in particular, as intermediates for the preparation of therapeutically useful heterocyclic thioformamides by converting the depicted cyano radical into a grouping -CSNHR wherein R represents a hydrogen atom or an alkyl (C1-4) radical.
Patent IE-841086-L (IE)
Title: Imidazoles.
IPC: C07D401/12
Filed: 1984-05-02
Abstract: The invention relates to the use of 1-H-imidazol-1-ethanol and compounds of the formula 
<CHEM>
 in which R represents an organic acid residue which does not bear further carboxyl groups, either in the free or salt form, as sebum synthesis inhibitors. 
<??>The invention also relates to parmaceutical preparations comprising a compound of formula I, and their preparation and to the compounds of formula I in which R is as defined above except the acetic acid residue, and their preparation.
Patent IE-791262-L (IE)
Title: Braided sealing packing
IPC: D04C3/02
Filed: 1979-08-08
Abstract: A braided packing comprises a plurality of outer core strands, braided together with a plurality of braid strands, the outer core strands extending helically along said packing and forming with the braid strands a braid having a normal twist extending helically in one direction, the braid strands extending over the core strands in a continuous helical pattern at an angle to the outer core strands and the normal helical twist of the braid, and a plurality of warp strands in rows between said braid strands extending helically in a direction opposite said braid strands. Apparatus for making the braided packing comprises a rotatable condenser adapted to grip the braid at the point to which the braid strands extend for braiding together and means for rotating the condenser. The method of braiding comprises rotating the braid at the point at which the braid strands come together.
[US4256011A]
Patent IE-43691-L (IE)
Title: Carpeting material
IPC: D05C17/02
Filed: 1976-06-18
Abstract: In a carpeting material of the kind comprising a backing fabric and fibres standing up from the backing fabric as pile or tufts, the pile or tuft fibres comprise 75 to 98 per cent by weight of conventional carpet fibres and 2 to 25 per cent by weight of stiff fibres or filaments arranged to act as dirt scrapers. The conventional carpet fibres are nylon, acrylic, regenerated cellulose, wool, polyester, cotton or polypropylene fibres, or a mixture of two or more of these, of less than 30 decitex per filament. The stiff fibres or filaments may be heavy monofilaments, for example of nylon, polyester or unplasticized polypropylene of from 30 to 300 tex, or they may be of metallic material. Alternatively, the stiff fibres can be in the form of twisted yarn which has been resinated to stiffen it. Processes for making the carpeting material are also described and claimed.[US4045605A]
Patent IE-32480-L (IE)
Title: Wall plug and fastener
IPC: F16B13/02
Filed: 1968-11-01
Abstract: 1,251,506. Wall plug. A. FISCHER. 8 Nov., 1968 [10 Nov., 1967], No. 52971/68. Heading F2H. A fastener 4 is anchored in a wall by a wall plug 7 which has a diameter equal to or slightly greater than that of the fastener and a wall thickness approximately equal to the average thread depth of the fastener, the diameter of the hole in the wall receiving the plug being substantially equal to that of the plug, so that on driving the fastener into the plug the wall of the plug is cut through at least partially along its length by the fastener thread. The plug bore tapers conically from each end, and a collar 9 is provided for retaining the plug in the hole prior to driving in of fastener 4. Alternatively the plug may have a portion of non-circular cross section to retain it in the hole. Slots may be provided in the plug at one or both ends and may run longitudinally or helically. The plug may be of synthetic plastics material. The fastener may be a wood screw.
[GB1251506A]
Patent IE-831335-L (IE)
Title: 3, 5-disubstituted indoles.
IPC: C07D209/08
Filed: 1983-06-07
Abstract: Indole derivatives of the general formula (I) are disclosed: <IMAGE> (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process.
[US4816470A]
Patent IE-841359-L (IE)
Title: A space-division optoelectronic switch device
IPC: H04B10/29
Filed: 1984-05-30
Abstract: The device comprises, for coupling the accesses of N first elements (fa) with the accesses of N second elements (fp) an distributer assembly (10) constituted by a stack of P flat and rigid distribution plates (11) having N waveguides (h) each coupled to the access of one of the second elements (fp) and a concentrator-selector assembly (20) constituted by a stack of N flat and rigid concentration and selection plates (21) having P waveguides and including an integrated strip (31) of P photodiodes which are coupled to the ends of the P waveguides, said assemblies being assembled to each other to couple the individual waveguides together. It is particularly applicable to optically broadcasting P programs to N subscribers.
[US4653850A]
Patent IE-39577-L (IE)
Title: Pharmaceutical compositions
IPC: A61K31/415
Filed: 1974-06-28
Abstract: Pharmaceutical compositions are produced which comprise combining an antimycotically effective amount of a compound of the formula R2OH ¦¦ R1O-C-C-R4 ¦ R3 or a pharmaceutically acceptable, nontoxic salt thereof, wherein R1 is unsubstituted or substituted aryl, R2 is hydrogen, alkyl or unsubstituted or substituted aryl, R3 is hydrogen, alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, and R4 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted aralkyl, PROVIDED THAT R3 and R4 are not both hydrogen atoms, in combination with a pharmaceutically-acceptable, nontoxic, inert diluent or carrier.
[US3968229A]
Patent IE-43389-L (IE)
Title: Addition of organic acids to acetylenic compounds cleavage of fusion protein
IPC: C07C7/12
Filed: 1976-07-07
Abstract: 1499646 Removing acetylenic compounds from hydrocarbons SNAMPROGETTI SpA 6 July 1976 [8 July 1975] 28110/76 Heading C5E Acetylenic compounds are removed from hydrocarbon mixtures containing them by contacting the mixtures with an organic acid in the presence of an acidic ion-exchange resin, the acidic groups of which have been substantially totally exchanged with both mercuric ions and alkali metal or alkaline earth metal ions, the acetylenes forming an addition compound with the organic acid. 
The esters formed may be removed by rectification. 
The preferred acid is acetic acid. 
The process may be carried out at 20-120‹ C. in the liquid or gaseous phases. 
The process may be used to purify ethylene, propylene, butadiene or mixtures thereof. 
(From GB1499646 A) 
[FR2317256A1]
Patent IE-41671-L (IE)
Title: Amidated immune globulins.
IPC: C07K16/00
Filed: 1975-09-05
Abstract: Amidated immunoglobulins suitable for intravenous administration are prepared by reacting immunoglobulins with a molar excess of a primary monoamine and a carbodiimide or its salt in weakly acidic to neutral aqueous solution. As a result of the amidation, the undesired complement binding by the immunoglobulins is prevented or at least substantially decreased without the antibody action of the immunoglobulins being impaired. The process can be applied to reduced immunoglobulins, in which at least one disulphide bond has been converted to two sulphydryl bonds.
[GB1517026A]
Patent IE-42021-L (IE)
Title: Filament trimmer
IPC: A01D34/73
Filed: 1975-10-14
Abstract: A disk-shaped filament holder and dispenser for a filament trimmer; the disk has a central attachment for a power drive and a plurality of circumferentially spaced holes through which a filament having one end secured to the disk is threaded; the free end of the filament during operation swings radially from the disk as the cutting filament, or filament trimmer; abrasive contour of the holes insures that the free end of the filament will fail first at the last hole through which threaded rather than at some portion of the free length; on such failure, centrifugal force pulls the stub end free from the hole at which failure occurred and swings it out radially from the disk at the next prior hole through which threaded, as a fresh cuttinglength of filament.
[US3895440A]
Patent IE-832302-L (IE)
Title: Triazole antifungal agents.
IPC: C07D249/08
Filed: 1983-09-29
Abstract: Triazole human, plant and seed antifungal agents of the formula:- <CHEM> where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF3, C1- C4 alkyl and C1-C4 alkoxy, or R is a 5-chloropyrid-2-yl group; R<1> is -CN, -CSNH2, or -CONR<2>R<3> where either (a) R<2> is H or C1-C6 alkyl, and R<3> is H, C1-C6 alkyl, benzyl, phenethyl, phenyl, -CH2CF3, adamantyl, pyridylmethyl, C3-C7 cycloalkyl, carbamoylmethyl, (C2-C4 alkenyl)methyl, 2-hydroxyethyl, 2-(dimethylamino)ethyl, 2-(methylthio)ethyl, 2-(methylsulphinyl)ethyl, 2-(methysulphonyl)ethyl or 2-phenoxyethyl; said benzyl, phenethyl, phenyl and phenoxy group being optionally ring-substituted by 1 or 2 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, I and CF3, (b) R<2> and R<3> taken together with the nitrogen atom to which they are attached represent a group of the formula:- <CHEM> where R<4> is H, C1-C4 alkyl, C2-C4 alkanoyl or (C1-C4 alkoxy) carbonyl; (c) R<2> is H or C1-C4 alkyl and R<3> is C2-C4 alkanoyl or benzoyl, said benzoyl group being otionally substituted by 1 or 2 substituents each independently selected from F, Cl, Br, I, CF3, C1-C4 alkyl and C1-C4 alkoxy; or (d) R<2> and R<3> are both (C1-C4 alkoxy)carbonyl; R<6> is H or CH3; and R<6> is H or CH3; and their pharmaceutically and agriculturally accectable salts. The compounds are useful as human and agricultural fungicides.
[EP0106515A2]
Patent IE-872367-L (IE)
Title: Envelope
IPC: B42D5/02
Filed: 1987-09-03
Abstract: The present           invention is concerned with An article constituting an envelope in which an insert is nested comprising a sheet (10) of material having given horizontal and vertical dimensions, the sheet having a first fold line (26) parallel to and between the horizontal end edges thereby providing first and second parts of the sheet and a second fold line (82) perpendicular to the first fold line,     a window in one of the parts of the sheet, and lines of adhesive on the sheet along portions of the edges thereof, the arrangement being such that the first part of the sheet may be folded along the first fold line (26) to overlie the second part of the sheet and then the overlaid parts of the sheet folded again along the second fold line (82) to provide a compartment of the envelope in which the insert is to be nested whereby the insert (83) is prevented by the second fold from moving to the window (56) and obscuring the view of an address through the window (56).
Patent IE-832415-L (IE)
Title: Rodent bait
IPC: A01N43/90
Filed: 1983-10-13
Abstract: A rodent bait comprising food and a poison, said poison being wholly in the form of, or contained in, one or more discrete poison-providing particles of such activity with respect to the rodent specie for which the bait is intended that each poison-providing particle provides a lethal dose with respect to an adult rodent of that specie, each poison-providing particle being substantially homogeneous and being of a particle size which is such that a rodent of the specie for which the bait is intended will take the particle into its mouth without prior nibbling.
Patent IE-822895-L (IE)
Title: Conveyor roll for conveying heated glass sheets
IPC: F27D3/02
Filed: 1982-12-07
Abstract: A conveyor roll (20,21,20') for conveying heated glass sheets on a horizontal roller conveyor of a glass sheet processing system is disclosed as including a shaft (42,70,42) having a support (44,72,80) of aromatic polyamide fibers for engaging the conveyed glass sheets. Kevlar fibers are preferably utilized for the support (44,72,80) so as to have the requisite thermal stability and resistance to cutting by broken glass. One embodiment of the roll (20) has a helically wrapped support (44) comprising braided Kevlar rope or an outer Kevlar sleeve (64) and a central core (62) which may be longitudinally extending metallic or glass fiber strands (66) or a helical spring (68). Another embodiment of the conveyor roll (21) includes a ceramic roll shaft (70) of fused silica extending through an outer sleeve (72) of Kevlar fibers. A further embodiment of the conveyor roll (20') includes a support (80) having annular conveying discs (82) made of Kevlar fibers and spaced along the length of the shaft (42). In each roll embodiment (20,21,20') the associated Kevlar support (44,72,80) preferably has an outer surface (46,74,86) of the same diameter as drive surfaces (56) on end members (52) of the shaft.
[US4421482A]