baber/WOPTO huggingface dataset:
Patent PT-656209-E (PT)
Inventor: FLAUGH MICHAEL EDWARD
IPC: A61K31/4045
Filed: 1994-11-16
Abstract: The present invention provides a method of treating desynchronization disorders using various melatonin analogs. The invention further provides pharmaceutical formulations suitable for use in such method.
Patent PT-781160-E (PT)
Inventor: INGELMAN MAGNUS
IPC: B01D29/50
Filed: 1995-09-07
Abstract: PCT No. PCT/SE95/01002 Sec. 371 Date May 15, 1997 Sec. 102(e) Date May 15, 1997 PCT Filed Sep. 7, 1995 PCT Pub. No. WO96/08300 PCT Pub. Date Mar. 21, 1996A filtering apparatus comprises: a pressure vessel; a plurality of filter elements arranged within the pressure vessel, the filter elements each having an upper end, a lower end and a side wall; filling bodies positioned within the filter elements; a first conduit for introducing compressed gas into the pressure vessel; a second conduit for transporting unfiltered liquid to and from the pressure vessel; and a third conduit for removing filtrate from the pressure vessel and transporting back-flushing liquid to and from the filter elements, the third conduit positioned proximate to a bottom portion of the pressure vessel and attached to the lower ends of the filter elements, such that the third conduit provides a support structure for the filter elements and the back-flushing liquid introduced via the third conduit fills the filter elements in a direction from the lower ends toward the upper ends, the volume of back-flushing liquid introduced into the filter elements limited by the filling bodies. A method of operating the filtering apparatus is also disclosed.
Patent PT-785789-E (PT)
Inventor: JUNIEN JEAN-LOUIS
IPC: A61K31/55
Filed: 1995-10-13
Abstract: The invention relates to diazepinoindoles of formula:   <IMAGE>   in which R is hydrogen, lower alkyl or lower alkoxy; A is aryl or nitrogen-containing heteroaryl, each of which is optionally substituted by from one to three groups of halogen, lower alkyl, haloalkyl, lower alkoxy and acetamido, or their racemic forms, isomers or pharmaceutically acceptable salts, wherein for the racemic forms of the (S) configuration, A is not phenyl, haloalkyl, or 2-indolyl when R is hydrogen, and for the racemic forms of the (R) configuration, A is not 2-indolyl when R is hydrogen. Also, the invention relates to a method for inhibiting cyclic nucleotide phosphodiesterase activity by administering these compounds to a subject in an amount which is therapeutically effective to inhibit cyclic nucleotide phosphodiesterase activity.
Patent PT-874801-E (PT)
Inventor: BOMMARIUS ANDREAS
IPC: C12P41/00
Filed: 1996-12-05
Abstract: The disclosure relates to a process for obtaining optically active L- alpha -aminocarboxylic acids from the corresponding racemic D,L, alpha -aminocarboxylic acids. The following steps are involved: (a) the D,L, alpha -aminocarboxylic acids are acetylated; (b) the N-acetyl-L- alpha -aminocarboxylic acid present in the mixture of N-acetyl-D,L, alpha -aminocarboxylic acids thus obtained is broken down enzymatically into the L- alpha -aminocarboxylic acid; (c) the L- alpha -aminocarboxylic acid is separated from the mixture, a quantity of a solution with N-acetyl-D(L)- alpha -aminocarboxylic acids and a quantity of acetate equivalent to the L- alpha -aminocarboxylic acid being retained; and (d) the N-acetyl-D(L)- alpha -aminocarboxylic acid is racemised and recycled for enzymatic breakdown. Known extraction processes involving steps (a) to (d) have the disadvantage of producing large quantities of salts. Specifically, the processes are far removed from the ideal equation, according to which one hundred percent of the acetic anhydride and the D,L, alpha -aminocarboxylic acids are converted to L- alpha -aminocarboxylic acids and acetic acid. Adjusting the retained solution from step (c) in such a way as to obtain a solution consisting essentially of N-acetyl-D-(L)- alpha -aminocarboxylic acid salt and free acetic acid in equilibrium with acetate and free N-acetyl-D(L)- alpha -aminocarboxylic acid and from which acetic acid is extracted by distillation makes it surprisingly easy to feed the solution formed as "mother liquor" following separation of the L- alpha -aminocarboxylic acids in the circuit and to achieve a materials balance as close as possible to the ideal.
Patent PT-883452-E (PT)
Inventor: DECKERT SERGE
IPC: B62D33/00
Filed: 1997-02-27
Abstract: A method for forming a one-piece skip body with a concave cross section from a large metal sheet (1) by imparting an approximate cross section to the sheet using shaping mechanisms (2) is disclosed. According to the method, the approximate cross section is maintained while a sealing plate (10) is secured to one end (9) and a stiffening reinforcement member (13) shaped according to the final cross section is attached to the other end (12). The longitudinal edges are stiffened then the most curved areas are mechanically treated and the shaping mechanisms (2) are released. The method is relevant to skip manufacturers and more generally to builders of utility vehicles.
Patent PT-1001797-E (PT)
Inventor: GABETTA BRUNO
IPC: A61K9/64
Filed: 1998-07-30
Abstract: A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.
Patent PT-968722-E (PT)
Title: Improved modified live brsv vaccine
Inventor: CHU HSIEN-JUE
IPC: A61K39/39
Filed: 1995-05-08
Abstract: The invention provides an improved BRSV vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises a modified live BRS virus and an adjuvant, which in combination provide immunity from BRSV infection after a single administration, and elicit an immune response specific to BRSV and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the BRS virus is strain 375, and the adjuvant comprises an unsaturated turpin hydrocarbon, preferably squalene or squalane, and a polyoxypropylene-polyoxyethylene block copolymer, most preferably one where the copolymer has a polyoxypropylene (POP) component with an average molecular weight of about 3250 to 4000 and the polyoxyethylene (POE) component comprises about 10-20% of the total molecule. The adjuvant may optionally include a surfactant, preferably a polyoxyethylenesorbitan monooleate.
Patent PT-1146865-E (PT)
Inventor: SANKARANARAYANAN ALANGUDI
IPC: C07C311/08
Filed: 1999-02-22
Abstract: Antiarrhythmic composition with controlled beta -adrenergic blockade comprises a combination of dextro- and laevo-rotatory isomers of sotalol or their salts in a ratio of 1.5:1-3.5:1. An independent claim is included for an oral or parenteral composition for treating cardiac ailments which comprises a combination of dextro- and laevo-isomers of sotalol. ACTIVITY : Antiarrhythmic; cardiant. In a test using Guinea pigs (Dunken Hartley) to demonstrate antiarrhythmic activity of different ratios of sotalol, ouabain was used to produce ventricular tachycardia. Sotalol (2:1 ratio (d:l)) resulted in complete protection against ventricular tachycardia at a dosage of 2.5 mg/kg. MECHANISM OF ACTION : beta -adrenergic antagonist.
Patent SG-43290-G (SG)
Title: Stable liquid detergent compositions
IPC: C11D1/12
Filed: 1990-06-20
Abstract: Heavy-duty liquid detergents containing sulfonate and alcohol ethoxylate sulfate anionic surfactants, ethoxylated nonionic surfactant, optional quaternary ammonium, amine or amine oxide surfactants, saturated fatty acid, polycarboxylate builder, a neutralization system comprising sodium, potassium and preferably low levels of alkanolamines, and a solvent system comprising ethanol, polyol and water. The compositions are isotropic liquids providing a high level of detergency performance and improved chlorine bleach compatibility.
Patent SG-97486-G (SG)
Title: Affixation board for equipment
IPC: H02B1/04
Filed: 1986-12-24
Abstract: 1. Mounting panel for equipment, provided on its surface with a network of ribs defining between them recesses (3a, 3b) which are intended to receive fixing screws (9), characterized in that the ribs extend in three different directions (XX, YY, ZZ) and define hexagons or triangles.
Patent IE-32959-L (IE)
Title: Alpha-aminobenzylpenicillin trihydrate compositions
IPC: C07D499/68
Filed: 1969-01-17
Abstract: 1,250,714. Penicillins. BRISTOL-MYERS CO. 17 Jan., 1969 [18 Jan., 1968], No. 2749/ 69. Heading A5B. Antibacterial compositions suitable for reconstitution with water to form suspensions for intramuscular use comprise a particulate alpha-aminobenzylpenicillin trihydrate represented by the formula wherein R 1 , R 2 and R 3 are the same or different and each is hydrogen, nitro, di-C 1-6 - alkylamino, C 1-6 -alkanoylamino, C 1-6 -alkanoyloxy, C 1-6 -alkyl, C 1-6 alkoxy, sulphamyl, chloro, iodo, bromo, fluoro, trifluoromethyl, C 1-6 - alkylthio, C 1-6 -alkylsulphonyl, carbo-C 1-6 -alkoxy, benzyl, phenethyl, cycloheptyl, cyclohexyl or cyclopentyl; in which the particles are coated with a physiologically acceptable hydrophilic surface active agent and a phsysiologically acceptable lipophilic surface active agent. The composition may also contain a physiologically acceptable preservative which may also be coated with the surface active agents. The penicillin is preferably alpha-aminobenzylpenicillin trihydrate, the lipophilic surface active agent may be lecithin, sorbitan monopalmitate, and/or sorbitan trioleate and the hydrophilic surface active agent may be a poly oxyalkylene derivative of sorbitan monopalmitate or sorbitan trioleate. The composition may be prepared by mixing particulate alphaaminobenzylpenicillin trihydrate of formula I having a size less than 100 mesh (U.S. sieve series standard) with an organic solvent (e.g. chloroform, methylene chloride, trichloroethylene, other or petroleum ether) solution of the surface active agents, evaporating the solvent to produce particulate trihydrate coated with a mixture of the surface active agents, and if necessary pulverizing the coated material so that not more than 1% by weight thereof is larger than 200 mesh. The compositions may also contain dodecyl gallate, ascorbic acid (or its Na salt), sodium acetate, NaCl, methylcellulose or polyvinylpyrrolidone.
[GB1250714A]
Patent IE-32863-L (IE)
Title: Halogeno-azacycloalkenes
IPC: C07D223/10
Filed: 1969-01-21
Abstract: 1,196,394. 1 - Formyl - 2 - halogenoazacycloalk-2-enes. AGRIPAT S.A. 21 Jan., 1969 [22 Jan., 1968], No. 3356/69. Heading C2C. Novel compounds of formula wherein A is C 4- C 10 branched or straight chain alkylene and Hal is halogen are prepared by reacting a compound of formula with an adduct of a formamide of formula R 1 R 2 NCOH (where R 1 and R 2 are C 1-5 alkyl or together with N form a heterocyclic ring) and an acid halogenating agent and hydrolysing the product. The novel compounds may be used to prepare e.g. the fungicides of Specification 1,058,521, for example 1-formyl-2-chloroazacycloheptene- 2 is nitrated to give 1-formyl-3-nitroazacycloheptan-2-one which is deformylated by refluxing with water and the 3-nitro-azacycloheptan-2-one hydrogenated to give 3-aminoazacycloheptan-2- one which is benzylated to give the 3-benzylaminoazacycloheptan- 2-one.
[GB1196394A]
Patent IE-33759-L (IE)
Title: Fishing reel attachment
IPC: A01K87/06
Filed: 1970-03-23
Abstract: 1,236,358. Fishing reel attachment. GARCIA CORP. 18 March, 1970 [24 March, 1969; 27 Jan., 1970], No. 13004/70. Heading A1A. [Also in Division E2] A Fishing reel (22), Fig. 1 (not shown), has a stalk (23) having a flattened foot 29 at its end, by which it is attached to a rod. The butt end of the rod has a flange 34 attached to it by insert 36. Formed integrally with the flange is a saddle 39, intermediate member 36, and male threaded section 47. A crotch 30 in the flattened foot 29 fits over saddle 39, and ribs 26 on flattened foot 29 engage grooves 37 on the flange 34. The flat foot 29 is held against flange 34 by locking disc 50 attached to locking member 41 which is screwed on to male threaded section 47. In a modification the locking disc (56), Fig. 8 (not shown), is screwed on to the end of the locking member (55), and is so arranged that the locking member cannot be completely unscrewed from the butt end of the rod. In alternative embodiments the crotch, and the rib and grooves on the foot member and flange can have different configurations. The screw connection between the locking member and the male screwthread may be a quick release thread. The locking member may be incorporated in the end of a second handle.
[GB1236358A]
Patent IE-800456-L (IE)
Title: Lunch box
IPC: B65D6/00
Filed: 1980-03-06
Abstract: The lunch box comprises a generally square base container and a correspondingly shaped cover each being integrally formed from the same polymeric material. The base container has an integral handle extending forwardly from one side and integrally formed hinge tabs extending rearwardly from an opposite side. The cover, in turn, has integrally formed hinge blocks with slots for receiving the hinge tabs. The arrangement is such that in open position, the top of the cover is coplanar with the bottom of the base container so that both cover and container can engage a flat surface and function as serving trays for contents in the box. In a second position, wherein the box is closed, the cover is simply swung by flexing of the hinge tabs over the top of the container to close the upper opening. The container and cover openings include cooperating lip and step structures providing an hermetic seal and also frictionally holding the cover in place on the container.
[US4216862A]
Patent FI-814091-L (FI)
Inventor: HOKI TSUNEO
IPC: C08L23/04
Filed: 1981-12-18
Abstract: Ethylenic polymer/styrenic polymer blend foams are prepared from blends of (1) an ethylenic polymer resin having a density of from 0.915 to 0.930 g/cm<3> and a melt index of from 0.2 to 2.6 grams/10 minutes and (2) a styrenic polymer resin having a melt flow rate of from 1.4 to 18 grams/10 minutes. Foams having an excellent overall combination of properties are obtained (1) when the density, D, of such foams is in the range of from 10 to 40 kg/m<3> and the 25 percent compressive strength, F, in kg/cm<2> is from 0.013D<1.15> to 0.024D<1.15> and (2) when the ratio, R, of the melt flow rate of the styrenic polymer employed divided by the melt index of the ethylenic polymer employed is from 7 to 90 and the content, Y, of the styrenic polymer in said blend, in parts by weight based upon 100 parts by weight of the ethylenic polymer resin, satisfies the following requirement: 10 </= Y </= 394.7 + 1.18R - 294.1 log (D).
Patent FI-820020-L (FI)
Inventor: ROWLAND GEORGE FERDINAND
IPC: A61K39/395
Filed: 1982-01-05
Abstract: There is described an immunoglobulin conjugate comprising an immunoglobulin or immunoglobulin fragment modified by one or more groups of the following formula which are covalently linked to it: <CHEM>   The conjugates are useful in the treatment of cancers and are made by reaction of the immunoglobulin or immunoglobulin fragment with desacetylvinblastine acid azide.
Patent FI-820107-L (FI)
Inventor: MIELENZ JONATHAN R
IPC: C12N9/28
Filed: 1982-01-13
Abstract: An improved process for producing a thermostable alpha-amylase enzyme is described. The gene coding for the alpha-amylase is incorporated into a chimeric plasmid which is produced in multiple copies by a host microorganism.
Patent FI-832543-L (FI)
Inventor: AUBERT DANIEL
IPC: C07D495/04
Filed: 1983-07-12
Abstract: This invention relates to new thieno [3,2-c] pyridine derivatives having the formula:    <IMAGE>  (I)  in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group   <IMAGE>  in which R1 and R2 are each independently of each other, hydrogen or a straight or branched lower alkyl group; or R1 and R2 form together and with the nitrogen atom to which they are attached a heterocycle which may include a second heteroatom such as oxygen or nitrogen, wherein the latter may be substituted by a lower alkyl or benzyl radical which may be substituted; and X represents hydrogen, a halogen or a lower alkyl radical; and their addition salts with pharmaceutically acceptable mineral or organic acids if Y represents the group OR or    <IMAGE> or with mineral bases if Y represents OH, as well as the two enantiomers or their mixture. The invention also relates to the preparation process of new thieno [3,2-c] pyridine derivatives and to their therapeutic application as blood-platelet aggregation inhibiting agents and antithrombotics.
Patent FI-852140-L (FI)
Inventor: GROSS PAUL
IPC: A61Q5/12
Filed: 1985-05-29
Abstract: PCT No. PCT/EP84/00336 Sec. 371 Date Jun. 20, 1985 Sec. 102(e) Date Jun. 20, 1985 PCT Filed Oct. 26, 1984 PCT Pub. No. WO85/02113 PCT Pub. Date May 23, 1985.Hair treatment agent and process for hair treatment on the basis of an alcoholic solution containing a synergistic combination of (A) 0.1 to 40% by weight cetyl alcohol lactic ester and (B) 0.5 to 30% by weight of a monomer quaternary ammonium compound as well as 0 to 15% by weight water. The hair treatment agent may be diluted with water before use. It is applied to the still wet hair after the hair wash and is rinsed off with water after a reaction time of from 3 to 5 minutes. An excellent improvement of the combabillity, the touch and the luster of the hair is noticed with respect to hair treatments with the sole content of one of the two components (A) or (B).
Patent IE-791205-L (IE)
Title: Novel oxothia compounds, processes for their preparation,¹pharmaceutical preparations containing these compounds and¹such compounds for therapeutic use
IPC: C07D333/68
Filed: 1979-08-08
Abstract: 2-Oxo-2,3-dihydro- benzo[b]thiophen compounds of the formula <IMAGE> in which Ph is a substituted or unsubstituted 1,2-phenylene radical, X is oxygen or sulfur, R1 is a substituted or unsubstituted heteroaryl radical bonded via a carbon atom and R2 is hydrogen, and their salts with bases have peripheral analgesic properties. They can be prepared by methods known per se and can be used as the active ingredient in pharmaceutical preparations.
[GB2024220A]
Patent IE-811233-L (IE)
Title: Thiophene sulphonamides
IPC: A01N41/06
Filed: 1981-06-03
Abstract: Compounds of the formula <CHEM> wherein A is SO2N(R3)C(O)N(R4)R5; R is C1-C4 alkyl, C3 alkenyl, OCH3, NO2, Cl, Br, SO2NR1R2 and SO2N(OCH3)CH3; R1 and R2 are independently C1-C3 alkyl; R3 is H or CH3; R4 is H, CH3 or OCH3; R5 is <CHEM> X, X<2>, Y, Y<1> and Y<2> are selected from various substituents; Z is N, methine or substituted methine; Q is O or CH2; and their agricultural salts; possess herbicidal activity, especially against broad-leaf weeds. They are also of interest as plant growth regulants. The compounds may be formulated for use in conventional manner. The compounds may be made by a variety of routes, e.g. by reacting an appropriately substituted thiophenesulfonyl isocyanate
[US4398939A]
Patent IE-851417-L (IE)
Title: Dihydropyridines
IPC: A61P9/08
Filed: 1985-06-06
Abstract: Dihydropyridine derivatives of the formula: <IMAGE> (I) and their pharmaceutically acceptable acid addition salts; wherein R is a substituted aryl group; R1 and R2 are each independently C1-C3 alkyl; Y is -(CH2)n- where n is 2, or -CH2CH(CH3)-; and Het is a 6-membered aromatic heterocyclic group attached to the adjacent oxygen atom by a carbon atom. The compounds have utility as anti-ischaemic and anti-hypertensive agents.
[US4618609A]
Patent IE-781471-L (IE)
Title: Pyrones
IPC: A61K31/35
Filed: 1978-07-21
Abstract: Novel 2,3,6-substituted-4-pyrones having activity as prostaglandin antagonists are disclosed, together with intermediates useful for the preparation thereof. Methods of using the compounds of this invention as prostaglandin antagonists are described.
[US4132847A]
Patent IE-831804-L (IE)
Title: Novel form of cefuroxime ester
IPC: C07C/
Filed: 1983-07-29
Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration. Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described. Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
[US4562181A]
Patent IE-821956-L (IE)
Title: Sulfur-substituted phenoxypyridines
IPC: C07D213/70
Filed: 1982-08-12
Abstract: Sulfur-substituted phenoxypyridines having antiviral activity are disclosed. Methods of using the sulfur-substituted phenoxypyridines to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions thereof.
Patent IE-882180-L (IE)
Title: Sanitary napkin
IPC: A61F13/15
Filed: 1988-07-15
Abstract: A sanitary napkin (10) is disclosed for providing a convenient means for disposal at minimum cost to the consumer. The napkin is capable of being rolled or folded and self-sealed for disposal and includes one or more flaps (12)(14) extending transversely from one end of the backing layer (20). The flap or flaps are wrapped around the edges (50)(51) of the rolled or folded napkin and sealed by adhesive means (16)(17) on the other end of the backing layer. Preferred adhesive means serve a dual purpose of providing for attachment to the undergarment and providing for sealing of the napkin prior to disposal.
Patent IE-812291-L (IE)
Title: Sterilisation of immobilised lactase
IPC: C12N11/08
Filed: 1981-10-01
Abstract: PURPOSE:Immobilize lactase is sterilized and washed by use of an aqueous solution containing antimicrobials, an acidic aqueous solution and an almost neutral aqueous solution to achieve the purpose without the deactivation of the lactase. CONSTITUTION:A lactase originating from Aspergillus oryzae is immobilized on a support or inclusively coagulating substance through covalent bonds or adsorbed on an ion exchange resin with micropores to prepare immobilized lactase. The resultant immobilized lactase is used to decompose lactose in a solution containing the same, then sterilized and washed. The sterilization and washing are effected by an appropriate combination selected from sterilization with a solution of pH 2-8.5 containing antimicrobials, sterilization with antimicrocidal solution of 2-4pH, sterilization with an aqueous solution of 6-8.5 pH containing both a detergent and anti- microbials are washing with water.
[JP57065183A]