baber/WOPTO huggingface dataset:
Patent WO-2020197882-A1 (WO)
Inventor: SZCZEPANKIEWICZ BRUCE
IPC: A61P11/00
Filed: 2020-03-18
Abstract: The invention relates to compounds and compositions for modulation of nicotinamide adenine dinucleotide (NAD+). The invention also relates to methods of making such compounds and compositions. The invention relates to pharmaceutical compositions containing one or more NAD+ modulating compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and/or improving cell and tissue survival.
Patent WO-2021066877-A1 (WO)
Title: A method of reducing neighboring word-line interference
Inventor: LEE SUNG-CHUL
IPC: G11C16/16
Filed: 2020-03-23
Abstract: Method for performing an erase program operation. Various methods include: erasing a block of cells by: applying a program pulse to a block of memory elements in the three-dimensional memory that programs the block of memory elements to a level below an erase verify level, where the three-dimensional memory comprises memory elements stacked vertically; performing a verify step to verify voltage levels of a group of memory elements; determining that a memory element of the group is outside of a threshold window defined between the erase verify level and a compact erase threshold amount; and applying a second program pulse to the memory element. Where erasing the block of memory elements creates an erased block, where a width of the voltage distribution of the erased memory elements in the erased block is the same as or below a width of a voltage distribution associated with programmed memory elements.
Patent WO-2020236293-A1 (WO)
Title: Systems and methods for adaptive routing in the presence of persistent flows
Inventor: ROWETH DUNCAN
IPC: H04L12/801
Filed: 2020-03-23
Abstract: System and methods are described for providing adaptive routing in the presence of persistent flows. Switches in a fabric have the capability to establish flow channels. Switches can adaptively route flows, while monitoring transmission characteristics of the flows channels to identify whether any flows are experiencing congestion towards a destination. In response to detecting congestion, it can be further determined whether the flow is related to a source of congestion, or alternative the flow is a victim of congestion. Flows that are a source of congestion have their routing constrained to prevent congestion from propagating For example, new packets of a flow that is a source of congestion may be forced to only take the path of the data transmission that detected said congestion (preventing congestion from spreading). Alternatively, victims of congestion do not have their routing constrained, and packets can take any path as permitted by adaptive routing.
Patent WO-2020198432-A1 (WO)
Inventor: Ye Qiaoyang
IPC: H04W52/38
Filed: 2020-03-26
Abstract: Systems, devices, and techniques for indicating the number of repetitions for a downlink control information (DCI) message are described. A described technique includes transmitting an indication of a repetition number for a downlink control information (DCI) message having a predetermined format for transmit power control (TPC) of an uplink channel by a user equipment (UE); and transmitting, to the UE via a machine-type communications physical downlink control channel (MPDCCH), repetitions of the DCI message in accordance with the predetermined format and in accordance with the repetition number. The predetermined format can based on a DCI format 3 or 3A for bandwidth-reduced low-complexity or coverage enhanced (BL/CE) UEs.
Patent WO-2020198714-A1 (WO)
Inventor: BENCH STEPHANIE
IPC: G01V3/08
Filed: 2020-03-27
Abstract: Front end circuits and associated apparatus, systems, and methods for use in electronic devices such as buried utility locators are disclosed. The circuits include receivers and filters on input signals that are coupled to ground rather than differentially. A multiplexing circuit allows shared use of amplifiers, and analog-to-digital converters via a switching mechanism for selectively making or breaking electrical connection to the receiver channels for efficient sharing of electronics resources while minimizing crosstalk interference and advantageously reducing costs.
Patent WO-2020227546-A1 (WO)
Title: T cell manufacturing compositions and methods
Inventor: VAN BUUREN MARIT M
IPC: A61K35/28
Filed: 2020-05-07
Abstract: The generation of antigen specific T cells by controlled  ex vivo  induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.
Patent WO-2020232433-A1 (WO)
Inventor: SADELAIN MICHEL
IPC: C07K16/28
Filed: 2020-05-18
Abstract: The presently disclosed subject matter provides polypeptide compositions comprising a chimeric antigen receptor (CAR) that targets mesothelin; and a dominant negative form of programmed death 1 (PD-1 DN). Also provided are immunoresponsive cells comprising such polypeptide compositions and uses of the polypeptide compositions and immunoresponsive cells for treatment, e.g., for treating solid tumors.
Patent WO-2020242875-A1 (WO)
Title: Hysteroscopy systems and methods for managing patient fluid
Inventor: PARNHAM LINDA T
IPC: A61M5/142
Filed: 2020-05-21
Abstract: A low profile surgical system includes a movable cart assembly, an endoscope, and a surgical instrument. The movable cart assembly includes a fluid source and a receptacle assembly that are in fluid communication with one another. The endoscope is operably coupled to the cart assembly and in fluid communication with the fluid source. The surgical instrument is operably coupled to the cart assembly. The surgical instrument and the endoscope are configured to dispense outflow fluid into the receptacle assembly.
Patent WO-2021257056-A1 (WO)
Title: Identification of mycotoxin absorption materials in clay deposits
Inventor: CARBO MARINA
IPC: G01N1/10
Filed: 2020-06-16
Abstract: A method for determining absorption properties in clay deposits is provided that includes obtaining a clay sample, preparing the clay sample, analyzing the clay sample, and applying one or more correlative models to the clay sample. Additionally a system for use in determining absorption properties in clay deposits is provided that includes a plurality of inorganic particles, an analytical instrument configured to gather physical and/or chemical data about the inorganic particles, and a computer system configured to accept the physical and/or chemical data and/or generate correlations between the inorganic particles based on the data.
Patent WO-2021066898-A1 (WO)
Inventor: TAMMELA SIMO KAARLO
IPC: G02B27/00
Filed: 2020-06-17
Abstract: The description relate to devices, such as augmented reality and/or virtual reality devices that employ optical waveguides. On example includes a first optical waveguide configured to receive light at an incidence angle and a second optical waveguide positioned in a non-parallel relation to the first optical waveguide. The second optical waveguide can be configured to receive the light through the first optical waveguide at a first location at the incidence angle, transmit the light within the second optical waveguide, and output the light from a second location back toward the first optical waveguide at the incidence angle.
Patent WO-2020257219-A1 (WO)
Inventor: BRUNNER DANIEL
IPC: H01F6/02
Filed: 2020-06-17
Abstract: A system comprises a superconducting magnet comprising a coil of superconducting material. The coil includes electrical terminals. The windings of the coil are separated by a metallic conductor. A control circuit is coupled to the terminals to drive a current through the coil to charge the superconducting magnet and configured to provide a current through the coil that is sufficiently small to avoid a quenching effect of the superconducting magnet but also large enough to charge the magnet within a predetermined time period. A cooling structure is thermally coupled to the coil to remove heat caused by charging the superconducting magnet with the current to allow for the current to be sufficiently large to charge the magnet within the predetermined time period without causing the quenching effect.
Patent WO-2021003421-A1 (WO)
Inventor: BARTSICH SOPHIE
IPC: A61P31/14
Filed: 2020-07-02
Abstract: Disclosed are methods of treating a patient exposed to MTV. Also disclosed is a purified cDNA encoding an MTV transition protein peptide chain. Also disclosed is a vaccine containing an MTV transition protein. A further version of the invention is a vaccine comprising MTV polypeptides coupled to a carrier protein. MTV may be treated by providing an MTV vaccine with an MTV transition protein; and, administering said vaccine. In further instances, the MTV vaccine is administered with an antiretroviral medication.
Patent WO-2021011235-A1 (WO)
Inventor: MADDAN ORVILLE
IPC: C01F5/14
Filed: 2020-07-07
Abstract: Nanoplatelet forms of monolayer metal hydroxides are provided, as well as methods for preparing same. The nanoplatelets are suitable for use in antimicrobial compositions, for pressure treating lumber against wood rot, termites, and fungus, for water treatment for the removal of heavy metal contaminants, for the production of plasmonics devices, for the production of ore, or for the recovery of valuable metals in, e.g., fly ash ponds, mine tailings ponds, or other fluids containing the metal in ionic form. The nanoplatelet forms include copper hydroxide nanoplatelets.
Patent WO-2021041740-A1 (WO)
Title: Compositions d'antagonistes opioïdes, dispositifs d'implant et procédés de traitement pour trouble d'utilisation opioïde
Inventor: WATKINS GREGORY A
IPC: A61P25/36
Filed: 2020-08-27
Abstract: L'invention concerne des compositions comprenant une formulation d'un antagoniste opioïde et d'un acide organique. L'antagoniste opioïde est une base et présente une solubilité dans l'eau à température ambiante inférieure à environ 1,0 g/l. L'acide organique est combiné à l'antagoniste opioïde dans un rapport molaire inférieur ou égal à 1:1 (acide:médicament), présente une solubilité dans l'eau à température ambiante entre 0,1 et 10 g/l et/ou présente une masse molaire inférieure à 400 grammes par mole. L'acide organique améliore la solubilité de l'antagoniste opioïde et facilite ainsi la libération de l'antagoniste opioïde dans un environnement tamponné d'utilisation pendant des périodes prolongées, par exemple, de six mois à un an. L'invention concerne également des dispositifs d'administration basés sur la diffusion, comprenant les compositions ainsi que des procédés de traitement.
Patent WO-2021046061-A1 (WO)
Title: Small molecule films for sacrificial bracing, surface protection, and queue-time management
Inventor: Blachut Gregory
IPC: H01L23/00
Filed: 2020-09-01
Abstract: The present disclosure relates to methods of forming a film including small molecules. Such methods can optionally include removing such small molecules, such as by way of sublimation, evaporation, or conversion to a more volatile form.
Patent WO-2021055418-A1 (WO)
Title: Systems and related sample loading manifold assemblies
Inventor: DREWS BRADLEY
IPC: B01L3/00
Filed: 2020-09-16
Abstract: An apparatus includes one or more valves adapted to be coupled to corresponding reagent reservoirs and a flow cell interface adapted to be coupled to a flow cell. The apparatus includes a sample cartridge interface having one or more ports and adapted to be coupled to a sample cartridge carrying a sample of interest. The sample cartridge interface positioned downstream of the flow cell interface. The apparatus includes a pump adapted to load a channel of the flow cell with the sample of interest via the flow cell interface associated with an outlet of the flow cell and a corresponding port of the sample cartridge interface.
Patent WO-2021055802-A1 (WO)
Title: Systems and methods for improved database intelligence
Inventor: CABRAL JOHN
IPC: G06F16/28
Filed: 2020-09-18
Abstract: Systems and methods for utilizing a single sequence of operations for querying data and processing operations on the data when that is stored in an extended form of predicate logic are described herein. The systems and methods described herein may support storing, querying, and performing operations on data stored in a form of predicate logic that is extended to include quoting. The inclusion of quoting enables predicate logic to store data about queries and rules, thereby allowing queries and operations on data about queries and rules. This extended form of data in combination with the infrastructure described herein allows for the creation of entire applications that are defined in the same data language as the data process by that application. This creates a unified infrastructure that enables user to query, analyze, and process both applications and the data processed by those applications via a common method.
Patent WO-2021062200-A1 (WO)
Inventor: SHELLMAN YIQUN
IPC: A61K31/337
Filed: 2020-09-25
Abstract: Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma. In many embodiments the targeted cells or tissues may not have BRAF mutations.
Patent WO-2021112952-A1 (WO)
Title: Cathode active material with silicon carbide additive
Inventor: SHIRPOUR MONA
IPC: H01M4/62
Filed: 2020-10-06
Abstract: A lithium battery cathode material comprises lithium transition metal-based material selected from lithium transition metal oxides and lithium transition metal phosphates, and crystalline silicon carbide residing at grain boundaries of the lithium transition metal-based material, forming conductive pathways along the grain boundaries, the crystalline silicon carbide being less than 10 wt.% of the cathode material.
Patent WO-2021087084-A1 (WO)
Title: COMPOUNDS AND MODULES FOR INHIBITION OF PRE-miR-21 AND THEIR USE IN TREATMENT OF CERTAIN CANCERS
Inventor: DISNEY MATTHEW D
IPC: A61P31/00
Filed: 2020-10-29
Abstract: Small molecule compounds and corresponding dimers having inhibitory activity against pre-miR-21 RNA and related methods for treatment of neoplastic disease such as cancer and especially cancers expressing miR-21 are disclosed.
Patent WO-2021097219-A1 (WO)
Title: Odor eliminating equipment bag
Inventor: WEBB DANIEL
IPC: F26B3/18
Filed: 2020-11-13
Abstract: An equipment bag includes a shell comprising interior surfaces defining an interior volume defined by a first height, a first width, and a first length, where the shell comprises lengthwise portions forming a circumferential enclosure along the first length shell and two end portions positioned at opposite ends of the lengthwise portions enclosing the interior volume about the first height and the first width of the shell, a removable heating element, where the removable heating element includes heating panels defined by a second length and a second width, the second length corresponding to dimensions of a perimeter of the interior volume defined by the first width and the first height and the second width corresponding to the first length of the interior volume, and fasteners positioned at locations on interior surfaces of the shell such that the removable heating element is selectively attached to the interior surfaces of the shell.
Patent WO-2021102105-A1 (WO)
Inventor: HEIKENFELD JASON
IPC: B01D61/00
Filed: 2020-11-19
Abstract: A device and method for increasing the concentration of an analyte in a fluid sample. The device may include: a housing defining a chamber therein for receiving a fluid sample, a membrane associated with the housing; and a pressure generator operatively connected to the housing to create a pressure gradient across the membrane. When the pressure generator is operated to create the pressure gradient, this causes at least a portion of the fluid sample to move across the membrane. As a result, the fluid sample is separated into a first portion of fluid and a second portion of fluid including said analyte on opposite sides of the membrane. This second portion of fluid - by having the analyte present in an amount of fluid that is reduced as compared to the fluid sample prior to the application of pressure - is thus the resulting analyte-concentrated fluid sample.
Patent WO-2021113089-A1 (WO)
Title: Split microplate and vials
Inventor: LODGE DANIEL
IPC: B01L9/00
Filed: 2020-11-20
Abstract: A split or two-part microplate is formed of a base and a rack. The rack has a top with a plurality of openings capable of holding glass vials. The base has an interior bottom surface and an exterior bottom surface and a plurality of upwardly extending vertical walls and the rack being so dimensioned and sized so as to fit onto the base with at least a portion of the top planar surface resting on the vertical walls. The rack includes downwardly extending legs that are adapted to rest on a flat surface. A plurality of vials are held in the openings and include rims preventing the vials from passing through the openings. Whereby, when the rack is resting on a flat surface, the vials hang from the rack and when the rack is assembled onto the base.
Patent WO-2021102398-A1 (WO)
Title: Procédés de notation de stade de sommeil avec apprentissage non supervisé et leurs applications
Inventor: RICHTER CLAUS-PETER
IPC: A61B5/372
Filed: 2020-11-23
Abstract: L'invention concerne un nouveau procédé de notation des stades de sommeil d'un sujet mammifère, comprenant l'extraction de caractéristiques à partir de données de polysomnographie à l'aide de la transformée en ondelettes continue ; le regroupement des caractéristiques extraites en groupes qui sont attribués à différents stades de sommeil ; et la notation des étapes de sommeil sur la base des groupes. Le procédé ne nécessite pas de connaissance visuelle préalable d'étapes de sommeil ni d'apprentissage supervisé.
Patent WO-2021108552-A1 (WO)
Title: Système et procédé d'atténuation de menace
Inventor: MURPHY BRIAN P
IPC: H04L29/06
Filed: 2020-11-25
Abstract: L'invention concerne un procédé mis en œuvre par ordinateur, un produit-programme informatique et un système informatique pour : établir une connectivité avec une pluralité de sous-systèmes pertinents pour la sécurité au sien d'une plate-forme informatique ; définir une requête unifiée sur une plate-forme unifiée concernant la pluralité de sous-systèmes pertinents pour la sécurité ; dénormaliser la requête unifiée pour définir une requête spécifique à un sous-système pour chaque sous-système de la pluralité de sous-systèmes pertinents pour la sécurité, définissant ainsi une pluralité de requêtes spécifiques à un sous-système ; et fournir la pluralité de requêtes spécifiques à un sous-système à la pluralité de sous-systèmes pertinents pour la sécurité.
Patent WO-2021141745-A1 (WO)
Title: Tomato plants with resistance to mi-1 resistance-breaking root-knot nematodes
Inventor: DURHAM KELLI M
IPC: C12Q1/68
Filed: 2020-12-17
Abstract: The present disclosure provides cultivated tomato plants exhibiting increased resistance to  Mi-1  resistance-breaking root-knot nematodes. Such plants comprise novel recombinant chromosomal segments comprising alleles associated with disease resistance from  Solanum pimpinellifolium  on chromosome 1 and/or chromosome 6. In certain aspects, compositions and methods for producing, breeding, detecting, and selecting plants or germplasm with an increased disease resistance phenotype are provided.
Patent WO-2021051123-A1 (WO)
Title: Zoom control in image capture
Inventor: LIU SHIZHONG
IPC: H04N5/345
Filed: 2020-08-10
Abstract: In general, techniques are described regarding adaptation of image capture modes to provide refined image capture capabilities. Cameras comprising image sensors configured to perform the techniques are also disclosed. An image sensor may use different image capture modes to capture frames of image data based at least in part on various operating conditions. For example, the processor can cause an image sensor to transition between image capture modes specifying different binning levels in the case that a digital zoom level satisfies a predefined threshold.
Patent WO-2021113866-A1 (WO)
Title: Improved semen processing for in vitro fertilization
Inventor: BOHRER RODRIGO
IPC: C12N5/076
Filed: 2020-12-03
Abstract: The present teachings provide for and include methods of preparing semen for in vitro fertilization (IVF). Provided are methods of removing dead cells from semen preparations by applying the semen to a colloidal silica gradient and centrifuging the gradient. In some configurations, the gradient is a 45-90% colloidal silica gradient and the centrifugation is at 419 x g. Further provided are use of the method of the present teachings for processing sex selected semen. Also provided are ova and zygotes matured therefrom that have been fertilized by semen that has been processed by a method of the present teachings.
Patent WO-2021142161-A1 (WO)
Title: Product packaging with internal lighting assembly
Inventor: PELL MATTHEW
IPC: B65D5/66
Filed: 2021-01-07
Abstract: A product package or packaging is configured such that: (i) the product(s) are obscured from a potential buyer's view when the product package 10 is in a closed position and (ii) the product(s) becomes visible to the potential buyer when an extent of the product package is in a partially opened position. Once the product(s) becomes visible to the potential buyer, an illumination assembly illuminates the product(s). This selective illumination of the product(s) permits: (i) the illumination assembly to be battery powered, (ii) highlights features and attributes of the product(s) in order to attract and keep the potential buyer's attention, and (iii) makes it easier to see the product(s) within the product package, which helps prevent potential buyers from removing the product(s) from the package thereby reducing the chance that the product is inadvertently damaged.
Patent WO-2021146529-A1 (WO)
Title: Processing unit, electronic device, and security control method
Inventor: CUI XIAOXIA
IPC: G06F12/14
Filed: 2021-01-15
Abstract: A processing unit comprising: a processor; and a memory, coupled to the processor and adapted to provide a plurality of enclaves isolated from each other, where the plurality of enclaves include a plurality of application enclaves, each of the application enclaves is used for running a respective application program, and the plurality of enclaves further include at least one of the following: a runtime enclave adapted to provide a storage space required for an invokable program; and a crypto enclave adapted to provide a storage space required for a crypto related program, wherein the runtime enclave and the crypto enclave have read/write permission for the plurality of application enclaves, and each of the application enclaves has no read/write permission for the runtime enclave and the crypto enclave.