baber/WOPTO huggingface dataset:
Patent JP-2619865-B2 (JP)
IPC: C12N/
Filed: 1986-11-07
Granted: 1997-06-11
Abstract: Process for increasing the rate of production of carbon dioxide, ethanol and other fermentation products such as citric acid, produced by yeast such as Saccaromyces cerevisiae during fermentation and decreasing biomass production by regulating the rate of glycolysis indirectly through changing the energy balance of the cell, i.e. by reducing intracellular ATP levels. Modifications for so altering the glycolysis rate involve the use of either a regulated ATP hydrolysis within the cell or a regulated leakage of ATP from the cell. This invention encompasses several ways for altering the yeast ATP level including (a) engaging futile metabolic cycles to increase ATP consumption; (b) using an altered exocellular acid phosphatase so that it becomes intracellular to increase intracellular ATP hydrolysis; (c) using a drug which uncouples the plasma membrane ATPase thereby consuming an abnormally high level of ATP; and (d) using a drug which allows the release of ATP from the cell to lower the intracellular ATP level. This invention further encompasses regulating the genetic modifications described in greater detail herein. By these means, such modifications may be turned off during growth of the yeast on a commercial scale, and then turned on before or during, and preferably before or at a very early stage of, the dough-rising phase.
Patent JP-H0614940-B2 (JP)
IPC: A61D1/02
Filed: 1989-10-18
Abstract: An applicator for administering a veterinary pharmacological composition comprises a container having a cannula extending therefrom and a two-piece cap for releasably covering the cannula. The cap has an internal seal for sealing the cannula against leakage and contamination.
Patent JP-H07102875-B2 (JP)
IPC: E04B1/58
Filed: 1990-08-29
Abstract: A cargo container which includes a plurality of elongated frame members (12) each having an elongated channel (31) and an elongated recess (30) therein. A plurality of coupling members (14) is removably engagable with ends of the frame members. A plurality of panels (51) is removably engagable with the elongated channels in the frame members and each of the panels having an elongated recess (54) around a perimeter thereof which, together with the elongated recess in each of the frame members, forms an elongated slot. A locking element (38) is removably insertable into the slots formed by the panel recesses and frame member recesses, when the panels are in engagement with the channels to lock the frame members, panels and coupling members into a substantially rigid assembly.
Patent JP-3841834-B2 (JP)
IPC: C07C55/08
Filed: 1998-08-10
Granted: 2006-11-08
Abstract: A process for preparing malonic acid from the hydrolysis of cyanoacetic acid in the presence of aqueous hydrochloric acid, the process conditions being such that they allow high yields in malonic acid product. The product of said acid hydrolysis is a mixture of malonic acid and ammonium chloride by-product; the mixture is concentrated, the ammonium chloride by-product is separated by dissolution with an oxygen solvent and isolated. Alternatively, said concentrated mixture is dissolved with a primary or secondary esterifying alcohol in C1-C10, the resulting mixture being esterified, while the ester product is purified by distillation under reduced pressure, the molar yields and purity of the ester product being high.
Patent JP-3293620-B2 (JP)
IPC: C12N15/11
Filed: 1990-08-27
Granted: 2002-06-17
Abstract: Recombinant negative strand virus RNA templates which may be used to express heterologous gene products and/or to construct chimeric viruses are described. Influenza viral polymerase, which was prepared depleted of viral RNA, was used to copy small RNA templates prepared from plasmid-encoded sequences. Template constructions containing only the 3' end of genomic RNA were shown to be efficiently copied, indicative that the promoter lay solely within the 15 nucleotide 3' terminus. Sequences not specific for the influenza vital termini were not copied, and, surprisingly, RNAs containing termini identical to those from plus sense cRNA were copied at low levels. The specificity for recognition of the virus-sense promoter was further defined by site-specific mutagenesis. It was also found that increased levels of vital protein were required in order to catalyze both the cap-endonuclease primed and primer-free RNA synthesis from these model templates as well as from genomic length RNAs. This indicated that this reconstituted system had catalytic properties very smilar to those of native viral RNPs. High levels of expression of a heterologous gene was obtained using the constructs and methods described.
Patent JP-2894636-B2 (JP)
IPC: C07D305/14
Filed: 1993-02-04
Granted: 1999-05-24
Abstract: PCT No. PCT/FR93/00111 Sec. 371 Date Aug. 3, 1994 Sec. 102(e) Date Aug. 3, 1994 PCT Filed Feb. 4, 1993 PCT Pub. No. WO93/16058 PCT Pub. Date Aug. 19, 1993This invention relates to novel anhydrides of general formula (I),    <IMAGE>  (I)  wherein Ar is an aryl radical, and either R1 is C6H5-CO or (CH3)3C-O-CO, R2 is a hydrogen atom and R3 is a hydroxy function protective grouping, or R1 is (CH3)3C-O-CO and R2 together form a saturated 5 or 6-membered heterocyclic ring; preparation thereof; and uses thereof for preparing taxane derivatives having general formula (III),    <IMAGE>  (III)  wherein R=H, acetyl; R1 is C6-H5-CO or (CH3)3C-O-CO), and having antitumoral properties.
Patent JP-2836966-B2 (JP)
IPC: B22D11/116
Filed: 1994-10-17
Granted: 1998-12-14
Abstract: A tundish and, more specifically, an impact pad is formed with a bottom impact surface and includes an outer side wall extending upwardly therefrom which fully encloses an interior space or cavity having an upper opening into which molten metal is directed from a ladle shroud. The outer side wall of the pad includes an inner surface extending from the bottom impact surface to the opening of the pad. The inner side wall surface includes an annular portion which extends inwardly and upwardly toward the opening of the pad. In the preferred embodiment, the inner side wall surface curves continuously from the bottom impact surface to a vertical wall defining the opening of the pad. The pad redirects the pouring stream back into itself causing the counter current flows to slow each other down thereby minimizing turbulence and inhibiting high velocity flow within the tundish. The upward flow is further is advantageously directed away from the incoming pouring stream toward the surface of the bath.
Patent JP-3621097-B2 (JP)
IPC: C07H11/00
Filed: 1993-12-07
Granted: 2005-02-16
Abstract: The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds,  beta -BCH-189 and related compounds. Furthermore, the stereochemistry at the nucleoside 4'-position can be controlled to produce enantiomerically-enriched  beta -BCH-189 and its analogues.
Patent JP-3709204-B2 (JP)
IPC: A61K31/4425
Filed: 1994-12-06
Granted: 2005-10-26
Abstract: PCT No. PCT/EP94/04049 Sec. 371 Date Aug. 23, 1996 Sec. 102(e) Date Aug. 23, 1996 PCT Filed Dec. 6, 1994 PCT Pub. No. WO95/15756 PCT Pub. Date Jun. 15, 1995A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active substance combination of at least one parasympathomimetic and at least one parasympatholytic.
Patent JP-4039683-B2 (JP)
IPC: A61K31/513
Filed: 1994-02-17
Granted: 2008-01-30
Abstract: A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.
Patent JP-3081647-B2 (JP)
IPC: F23G7/10
Filed: 1996-03-06
Granted: 2000-08-28
Abstract: A gasifier is disclosed. The gasifier comprises a primary chamber for receiving therein biomass waste material and other related volatile solids to be gasified. A fume transfer vent permits the escape of fumes from the primary chamber. A mixing chamber accepts the fumes from the fume transfer vent. The fumes then flow to an afterburner chamber where a burner member produces a heating flame so as to cause the additional full oxidization of the constituents of the fumes so as to oxidize the constituents. A partitioning wall is disposed between the flame chamber and the primary chamber so as to preclude the heating flame from entering the primary chamber and to also preclude the radiation from the heating flame from directly entering the primary chamber, thereby precluding direct contact and physical disturbance of the waste material. A heat transfer chamber in fluid communication with the afterburner chamber accepts the fully oxidized fumes therefrom. The heat from the full oxidation of the fumes causes heating of the heat transfer chamber. The primary chamber has a heat conductive floor and is superimposed on the heat transfer chamber with the heat conductive floor being disposed in separating relation therebetween so as to permit conductive and convective heating of the primary chamber, thus causing heating of the waste in the primary chamber. An exhaust vent in fluid communication with the heat transfer chamber permits venting the fumes to the ambient surroundings.
Patent JP-4021941-B2 (JP)
IPC: G06Q30/00
Filed: 1998-01-20
Granted: 2007-12-12
Abstract: The present server based communications system provides dynamic customization of hypertext tagged documents presented to clients accessing the system. The customization, which pertains to the content of the documents, is based on the specific requirements of a class to which the client belongs to. The class may be defined by the identity of the source which refers the client to the system. The system utilizes a database which dynamically retrieves stored data in response to a server software tool which configures the data into hypertext tagged documents. The system utilizes a dynamic token scheme to pass the identity of the referring network site from document to document to eventual purchase document accessed by the client through the hypertext tags.
Patent JP-3529388-B2 (JP)
IPC: B01L3/00
Filed: 1996-05-01
Granted: 2004-05-24
Abstract: The invention is an improved single-step test device for detecting the presence of a pre-selected analyte in a urine stream. The device has a hollow outer casing and an assay material disposed within the casing. The outer casing defines: a urine inlet port; a viewing window; and at least one drainage vent spaced about the urine inlet port. The assay material is a sorptive material defining: a urine sample application region adjacent to, and in fluid communication with the urine inlet port; a capture region adjacent to the viewing window; and a fluid flow path for transporting liquid sample between the urine sample application region and the analyte capture region. The drainage vent is located to permit excess urine entering the casing from the urine stream to exit the casing thereby to minimize hydraulic pressure induced flooding of the assay material disposed within the casing and to reduce the frequency of false test results.
Patent JP-3326183-B2 (JP)
IPC: B65G47/46
Filed: 1998-01-20
Granted: 2002-09-17
Abstract: An automated conveyor sortation and item discharge system for sorting items of varying sizes and weights to designated output destinations along a conveyor. The system utilizes a segmented slat conveyor connected by flexible connectors. The flexible connectors form a tooth for driving the conveyor by a sprocket. The flexible connectors isolate adjacent slats, and the flexible teeth isolate the slat conveyor from the drive sprocket for a enhanced reduction in noise levels. The system may utilize a conventional belt conveyor or rigid platforms attached by flexible connectors. Removable ejection mechanisms can be attached to the individual slats of the slat conveyor or to the belt of a belt conveyor. The ejection mechanisms have self-contained drive and actuation mechanisms and may operate independently of the speed of the conveyor. The drive mechanism for the ejection mechanism may be located separately from the ejection mechanism to drive the ejection mechanism when the ejection mechanism moves adjacent to a desired discharge destination. A programmable controller may be provided to control the conveyor and the discharge of items from the conveyor by the ejection mechanisms. The system is easy to repair and operates at high speeds at reduced noise levels.
Patent PL-156737-B2 (PL)
Title: Method and system of controlling the thyristor converter operating wave-wise
IPC: H02H/
Filed: 1987-05-08
Abstract: Control circuit for a thyristor-based converter designed to function as an inverter, containing a phase control circuit, a synchronization circuit, a signal transmitter and two-input gate amplifiers, characterized in that the two-input gate amplifiers (4A, 4B, 4C, 4D, 4E, 4F), all of whose second inputs are connected to the output of the phase control circuit (2) and whose outputs are connected to the thyristor-based converter (3), have their first inputs connected to circuits producing forced triggering pulses, consisting of window discriminators (5A, 5B, 5C, 5D, 5E, 5F) detecting when the supply voltages pass zero and, connected to them, detectors (6R, 6S, 6T) of momentary values of the supply voltages, connected to the synchronization circuit (7).<IMAGE>
Patent ES-2293831-B2 (ES)
Title: Procedimiento para la recuperacion del germanio presente en cenizas de carbon.
Inventor: ARROYO TORRALVO FATIMA
IPC: C22B41/00
Filed: 2006-07-03
Granted: 2008-12-16
Abstract: Procedimiento para la recuperación del germanio presente en cenizas de carbón. El objeto de la presente invención se refiere a un procedimiento hidrometalúrgico para la recuperación del germanio presente en cenizas de carbón que implica tres etapas: 1) lixiviación de la ceniza para obtener una disolución acuosa de Ge; 2) extracción líquido-líquido con un sistema formado por catecol como agente complejante del Ge, unido a un extractante orgánico constituido por una amina grasa o un compuesto de amonio cuaternario en un disolvente adecuado; dicho sistema actúa de forma selectiva sobre el Ge, separándolo de otros metales y concentrándolo unas 100 veces con respecto a la solución acuosa de partida (lixiviado), y 3) precipitación del Ge para dar finalmente, tras su separación y calcinación, un producto sólido comercializable de Ge de gran pureza.
Patent AU-2001263275-B2 (AU)
Title: Method and apparatus for identifying related searches in a database search system
Inventor: HAUGAARD BRADLEY R
IPC: G06F17/30
Filed: 2001-05-18
Granted: 2005-07-21
Abstract: A method of generating a search result list also provides related searches for use by a searcher. Search listings which generate a match with a search request submitted by the searcher are identified in a pay-for-placement database which includes a plurality of search listings. Related search listings contained in a related search database generated from the pay-for-placement database are identified as relevant to the search request. A search result list is returned to the searcher including the identified search listings and one or more of the identified search listings.
Patent AU-2001264680-B2 (AU)
Title: Cannabinoid drugs
Inventor: BURSTEIN SUMNER
IPC: A61K31/353
Filed: 2001-05-17
Granted: 2006-09-14
Abstract: The invention relates to the use of cannabinoid compounds (derivatives of tetrahydrocannabinol) for decreasing cell proliferation in a mammal.
Patent AU-2001268549-B2 (AU)
Title: Cap piercing station for closed container sampling system
Inventor: KATZMANN STEVEN P
IPC: G01N1/10
Filed: 2001-06-19
Granted: 2006-09-28
Abstract: A piercing station for piercing sample container caps or thick stoppers. The piercing station has a structural frame with two vertical guide rods. A carriage assembly is slidably mounted on the guide rods and is further driven to move up and down along the guide rods. The carriage assembly carries a blade holder, which in turn holds a piercing blade assembly. The blade assembly includes a center blade and two cross blades interlocked together, such that the blade assembly has a generally modified "H"-shaped cross section for piercing a cap on the sample container. Lubricant left in or on the sample container cap by the piercing station reduces the force required by the sample probe to penetrate thick stoppers for sample aspiration and level sensing. The "H"-shaped cut helps to equalize the pressure in the sample container during sampling, so that clot detection is more effective.
Patent AU-2002257681-B2 (AU)
Title: Novel use of a peptide class of compound for treating non neuropathic inflammatory pain
Inventor: SELVE NORMA
IPC: A61K31/445
Filed: 2002-03-19
Granted: 2007-06-07
Abstract: The present invention concerns the use of compounds of the Formula (I): <CHEM> for treating different types and symptoms of acute and chronic pain, especially non neuropathic inflammatory pain in mammals. The pain to be treated may be e.g. chronic inflammatory pain, rheumatoid arthritis pain and/or secondary inflammatory osteoarthritic pain. The compounds show an antinociceptive profile and differ from classical analgesics like opioids and non-steroidal anti-inflammatory drugs (NSAIDS) and are useful as specific analgesics.
Patent AU-2002303559-B2 (AU)
Title: Electrically interconnected snap for dolls
Inventor: MARINE JON C
IPC: A63H3/36
Filed: 2002-04-30
Granted: 2005-01-20
Abstract: An interactive, animated, robotic doll including a body, a processor, terminals linked to the processor, and a removable attachment. The terminals are connected to metal snaps on the body and the removable attachment includes complimentary snaps that secure the garment to the doll body. An electric circuit is completed when the attachment is secured by the snaps to the doll.
Patent AU-2002304883-B2 (AU)
Title: Device for the treatment of tumours
Inventor: SCHONFELD ANDREAS
IPC: A61N1/20
Filed: 2002-03-30
Granted: 2006-11-02
Abstract: In apparatus for the treatment of tumors, comprising at least one generator having a power source, and at least two electrode needles for conducting current into, or out of, a tumor, a control arrangement is provided for limiting the current flowing through each electrode to a maximum value.
Patent AU-2002320825-B2 (AU)
Title: Particles containing fabric conditioner
Inventor: MISTRY KISHOR KUMAR
IPC: C08F220/34
Filed: 2002-06-06
Granted: 2007-10-11
Abstract: A particulate composition comprising particles having a polymeric matrix including a fabric conditioning active ingredient and wherein the polymeric matrix is formed of a co-polymer of (a) an ethylenically unsaturated hydrophobic monomer with (b) a free base monomer. Preferably the composition is comprised in a detergent concentrate in which the particles are dispersed wherein the fabric conditioner is not released in the concentrate or during the wash cycle of a laundry operation but is released during the rinse cycle of said laundry operation.
Patent AU-2002321305-B2 (AU)
Title: Fume cupboard
Inventor: GARTNER ULRICH
IPC: B08B15/02
Filed: 2002-08-14
Granted: 2007-10-04
Abstract: The fume cupboard has a housing enclosing working chamber (3) which is open on one side, with air jets (21,22) directing additonal air onto the inner surfaces of the housing base (3) and lateral sides, the air jets following the contour of the inner surfaces. The side posts (8) and the front edge (11) of the working chamber can be provided as flow profiles incorporating air jet devices
Patent AU-2002332731-B2 (AU)
Title: Method and process for producing youthful-appearing, small-pored, and smooth skin
Inventor: PARSONS DIANA J
IPC: A61Q17/00
Filed: 2002-08-28
Granted: 2008-07-10
Abstract: The method and process for producing youthful appearing, small-pored, and smooth skin comprises pretreating the skin topically with retinoic acid, applying a contaminate in oil to the skin, and removing the contaminate by exploding or rupturing it with laser light. When treating the face, removing the contaminate requires only about 4 minutes. The laser light itself does not injure the skin but the rupture of the contaminant produces thermal injury in the high dermis leaving the epidermis intact. Repeated intermittent laser treatments and applications of topical retinoic acid produces the desired results in the skin indefinitely as long as the treatments and applications are continued.
Patent AU-2002351957-B2 (AU)
Title: Modified anti-TNF alpha antibody
Inventor: BAKER MATTHEW
IPC: A61P43/00
Filed: 2002-11-11
Granted: 2009-09-03
Abstract: This invention pertains to a TNF alpha-binding polypeptide composition comprising at least one of a modified heavy chain variable region polypeptide or a modified light chain variable region polypeptide that is capable of specifically binding to human TNF alpha. The modified heavy and light chain variable region polypeptides of the TNF alpha binding polypeptide are modified by at least one amino acid residue substitution, deletion or addition and are homologous to the heavy and light chain variable regions, respectively, of a non-human monoclonal antibody that specifically binds human TNF alpha. The polypeptide compositions of the invention comprising modified heavy and light chain variable region polypeptides are less immunogenic in a human than are the homologous heavy and light chain variable region polypeptides from a non-human animal.
Patent AU-2002353193-B2 (AU)
Title: 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents
Inventor: BERRY JANE MARIE
IPC: A61K31/404
Filed: 2002-12-20
Granted: 2010-03-25
Abstract: This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/thioredoxin reductase inhibitors: formula (I) wherein: Ar is a 1-(sulfonyl)-1H-indol-2-yl group; the bond marked alpha is independently: (a) a single bond; or: (b) a double bond; the bond marked beta is independently: (a) a single bond; or: (b) a double bond; the group -OR<SUP>O </SUP>is independently: (a) -OH; (b) an ether group (e.g., -OMe); or: (c) an acyloxy (i.e., reverse ester) group (e.g., -OC(-O)Me); each of R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>5</SUP>, and R<SUP>6</SUP>, is independently a ring substituent and is: (a) H; (b) a monovalent monodentate substituent; or: (c) a ring substituent which, together with an adjacent ring substituent, and together with the ring atoms to which these ring substituents are attached, form a fused ring; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), and/or conditions mediated by thioredoxin/thioredoxin reductase.
Patent AU-2003219016-B2 (AU)
Title: Anti-infective agents and/or immunomodulators used for preventive therapy following an acute cerebrovascular accident
Inventor: MEISEL CHRISTIAN
IPC: A61K38/21
Filed: 2003-03-05
Granted: 2008-10-16
Abstract: The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical preparations are anti-infective agents and/or immunomodulating agents, e.g. cytokines and/or inhibitors of the SNS.