baber/WOPTO huggingface dataset:
Patent NZ-582158-A (NZ)
Title: Pharmaceutical compositions for the treatment of chronic heart failure comprising pyrazolopyrimidinone derivative compound
Inventor: YOO MOO-HI
IPC: A61K31/519
Filed: 2008-06-03
Abstract: Disclosed is the use of a pyrazoloprimidinone derivative represented by Formula 1 for the treatment of chronic heart failure. The derivative can inhibit cardiac morphological changes, ventricular cavity enlargement and changes in ventricular wall thickness.
Patent NZ-582815-A (NZ)
Title: Therapeutic use of anti- tweak receptor antibodies to treat cancer
Inventor: CULP PATRICIA
IPC: C07K16/28
Filed: 2008-08-04
Abstract: Discloses anti-TWEAK-receptor antibodies or antigen binding fragment thereof, which can inhibit or prevent the growth of a solid tumour expressing SEQ ID NO:2; comprising: (i) Heavy chain CDR1 encoded by SEQ ID NO:120 with allowed amino acid substitution (ii) Heavy chain CDR2 encoded by SEQ ID NO:121 with allowed amino acid substitution (iii) Heavy chain CDR3 encoded by SEQ ID NO:122 with allowed amino acid substitution (iv) Light chain CDR1 encoded by SEQ ID NO:127 with allowed amino acid substitution (v) Light chain CDR2 encoded by SEQ ID NO:128 with allowed amino acid substitution (vi) Light chain CDR3 encoded by SEQ ID NO:129 with allowed amino acid substitution Further disclosed are anti-TWEAK-receptor antibodies or antigen binding fragment comprising a VH region comprising either SEQ ID NOs: 3, 5, 7 or 9 and VL region comprising either SEQ ID NOs: 4, 6, 8 or 10. Further disclosed are said antibodies which may be linked to an effector moiety and which may be used in the manufacture of a medicament for treatment of cancers.
Patent NZ-583624-A (NZ)
Title: Pyrrolidin-2-one derivatives as androgen receptor modulator
Inventor: HASUOKA ATSUSHI
IPC: A61K31/4015
Filed: 2008-08-06
Abstract: Disclosed are compounds of formula (I), prodrugs and salts thereof, and methods for their preparation. Specific examples of compounds of formula (I) include: 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, 2-Chloro-4-[(4R,5S)-5-ethyl-3,3-difluoro-4-hydroxy-2-oxopyrrolidin-1-yl]benzonitrile, 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, and 2-Chloro-4-[(2S,3S,4S)-2-ethyl-3-hydroxy-4-methyl-5-oxopyrrolidin-1-yl]benzonitrile. Also disclosed are pharmaceutical agents comprising compounds of formula (I) which act as tissue-selective androgen receptor modulators and agonists. These agents are useful for preventing or treating hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis and can also act as a frailty suppressant, a muscle strength enhancer, a muscle increasing agent, a cachexia suppressant, a body weight decrease suppressant, an agent for the prophylaxis or treatment of prostate hypertrophy, amyotrophy or muscle loss caused by a disease or an agent for reducing the prostate weight.
Patent NZ-586831-A (NZ)
Title: 6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
Inventor: BAXTER ELLEN
IPC: C07D215/38
Filed: 2009-01-27
Abstract: Disclosed is a compound of formula (I) wherein R1 is selected from the group consisting of C1-4alkyl, C3-8cycloalkyl, 5-6 membered heteroaryl, -(C1-4alkyl)-(5-6 membered heteroaryl), 5-6 membered heterocycloalkyl and -(C1-4alkyl)-5-6 membered heterocycloalkyl; R2 is selected from the group consisting of hydrogen and halogen; L1 is selected from the group consisting of -CH2-NRA-, -CH2CH2-NRA, - CH2-O- and -CH2-S-; wherein RA is selected from the group consisting of hydrogen, C1-4alkyl, -C(O)-C1-4alkyl, -C(O)O-C1-4alkyl and -SO2-C1-4alkyl; R3 is selected from the group consisting of C1-4alkyl, carboxy substituted C1-4alkyl, C4-8cycloalkyl, -(C1-4alkyl)-C4-scycloalkyl, partially unsaturated carbocyclyl, -(C1-4alkyl)-(partially unsaturated carbocyclyl), aryl, -(C1-4alkyl)-aryl, heteroaryl, -(C1-4alkyl)-heteroaryl, heterocycloalkyl and -(C1-4alkyl)heterocycloalkyl; wherein the C4-8cycloalkyl, aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, carboxy, C1-4alkyl, fluorinated C1-4alkyl, - C1-4alkoxy-, fluorinated -C1-4alkoxy, -C1-4alkyl-OH, -C1-4alkyl-CO2H and phenyl; alternatively, RA and R3 are taken together with the nitrogen atom to which they are bound to form a ring selected from the group consisting of 5 to 6 membered heteroaryl and 5 to 6 membered heterocycloalkyl; or a pharmaceutically acceptable salt thereof.
Patent NZ-587884-A (NZ)
Title: Crosslaminate of biaxially oriented and stretched films which are are laminated selectively to help arrest tears
Inventor: RASMUSSEN OLE-BENDT
IPC: B32B7/03
Filed: 2006-05-11
Abstract: A method for forming a cross-laminate web by segmental transverse stretching is disclosed. The web formed from two cross-oriented, semi-fibrillated, heat sealed plies of thermoplastic polymer films. The cross-laminate consists of linear thin (116) regions of bi-axially oriented material and thicker linear bosses (114) between the thinner regions. The method for forming the cross-laminate (1) involves segmental stretching of the material to form thinner regions (116) between the bosses using an apparatus comprising intermeshing grooved stretching rollers (112, 113). The mutually intermeshing grooved rollers which effect the segmental transverse stretching have flat crests (114) on their circular teeth (flat seen in cross-section) with relatively sharp edges (115). The segmental stretching starts on these edges and develops into thin continuous webs (116). The intermeshing is limited such that there are maintained thicker material, bosses, on the flat crests (114) of the circular teeth.
Patent NZ-591545-A (NZ)
Title: Method and arrangement to control a repeater in a wireless communication system
Inventor: HOYMANN CHRISTIAN
IPC: H04B7/155
Filed: 2008-09-24
Abstract: 591545 Disclosed is a method in a control unit (150) for controlling a repeater (100) or a relay of a radio access network (110). The method is performed by sending, to the repeater (100) or the relay, a repeater control message through a tunnel (160) as ordinary data communication. The tunnel (160) is created by a setting up an available radio communication channel from the control unit (150) to the repeater (100) or relay within the radio access network (110) by addressing a SIM card, a mobile phone number, or an Internet protocol "IP" address of the repeater (100) or the relay. The communication channel is set up such that the radio network (110) believes that the repeater control message is an ordinary data communication and is unaware that it is a control message that is sent. The repeater control message is configured to control the repeater (100) or the relay.
Patent NZ-595498-A (NZ)
Title: Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
Inventor: GRAY KEVIN A
IPC: A23L35/00
Filed: 2006-12-08
Abstract: Disclosed is an isolated, synthetic or recombinant nucleic acid comprising a nucleic acid sequence having at least 70% or more sequence identity to SEQ ID NO: 103, as defined in the complete specification. The disclosed nucleic acid encodes a polypeptide having an arabinofuranosidase activity,
Patent NZ-596191-A (NZ)
Title: Use of pufas for treating skin inflammation
Inventor: KELLIHER ADAM
IPC: A61P17/00
Filed: 2010-04-29
Abstract: The disclosure relates to the use a polyunsaturated fatty acid (PUFA) derivative of general formula I in the manufacture of a medicament for topical treatment of skin inflammation in a mammal. The skin inflammation may be caused by atopic eczema, contact dermatitis, psoriasis, uremic pruritis electromagnetic radiation. The medicament may be co-administered with a corticosteroid.
Patent NZ-597093-A (NZ)
Title: Wheelbarrow
Inventor: WESTPHAL FRIEDRICH
IPC: B62B1/18
Filed: 2011-03-01
Abstract: A wheelbarrow with a frame (1) formed from at least one hollow body (3) is disclosed. The wheelbarrow also comprises at least one pivot-mounted wheel on the frame, with at least two handle bars (5) with grips (6) for the frame located on the handle bars. The wheelbarrow is also provided with at least two supports (7) for the frame and a load-carrying facility (2) located on the frame. In various sections of the hollow body of the frame the cross-section differs, particularly transiting between an oval external shape and a circular shape along the handle bars of the frame (see figure 2). The oval shaped cross section has the greatest elongation in the vertical direction, so as to provide greater stability and torsion resistance in the vertical direction. Furthermore, the hollow body has wall thicknesses differing in various straight section of the frame. This may be such that in sections in which high forces act the wall thickness is greater to provide greater stability.
Patent NZ-619937-A (NZ)
Title: Fungicidal substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds
Inventor: DIETZ JOCHEN
IPC: C07D303/22
Filed: 2012-07-12
Abstract: Provided are fungicidal substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds, of general formula (I), wherein the variables as defined in the specification. Further provided are processes for their preparation and intermediates for preparing them. The compounds can be used to combat phytopathogenic fungi.
Patent NZ-624380-A (NZ)
Title: An improved flashing and joiner for window installations
Inventor: DEAN COSTA
IPC: F16B17/00
Filed: 2014-04-30
Abstract: A flashing(2) and a frame comprised of a number of lengths of the flashing, for use in the installation of building openings such as window frames are disclosed. Window frames are set into the building framework and usually the cladding butts up against the window frame. Given the myriad of cladding types and building construction styles the junction between the window frame and the cladding is often problematic since it varies depending on the type of window frame and the type of cladding in each construction situation. It would be desirable if a product were provided that made for a consistent platform for window installation and which was suitable for most commonly used window types, configurations and cladding types. Such a frame is disclosed. The flashing has a window frame support plate (4) having a window frame side and building framework side. A first longitudinal wall (14) extends from the window frame side of the support plate and a longitudinal stiffening formation (17) is continuous with the plate for imparting rigidity to it. The stiffening formation may be a box section. A joiner to connect the frame parts is also disclosed. Use of spacers (3) is also disclosed to assist in the drainage of condensation from interior spaces (21) of window frames (22).
Patent NZ-627281-A (NZ)
Title: Panelized structural system for building construction
Inventor: LASTOWSKI MICHAEL J
IPC: E04B1/18
Filed: 2010-12-09
Abstract: An integrated structural truss panel 20 configured to laterally transfer vertical live and dead load and lateral load to a structural column in a building comprising first, second, third, and fourth horizontal elongated members 26, 30, 32, 28 first and second vertical elongated members 36, 38 fastened to the first, second, third, and fourth horizontal elongated members 26, 30, 32, 28 such that the first and fourth horizontal elongated members 36, 28 form respectively a top and a bottom of the structural truss panel 20, and the first and second vertical elongated members 36, 38 form respective sides of the structural truss panel 20, such that first, second and third horizontal elongated members 26, 30, 32, 28 form an integrated web truss for attachment to floor and/or ceiling trusses, and such that the second and third horizontal elongated members 30, 32 form a continuous double horizontal brace that connects to each of the first and second vertical elongated members 36, 38and that continuously bridges between the first and second vertical elongated members forming the sides of the structural truss panel 20. An angled webbing 40 fastened between the first and second vertical elongated members 36, 38 and the first and second horizontal elongated members 26, 34 thereby creating an integrated web truss within the structural truss panel 20. The integrated web truss acts as a transfer beam and facilitates the lateral transfer of vertical live and dead load and lateral load on the structural truss panel 20 to the structural column
Patent NZ-628187-A (NZ)
Title: System and method for determining a property of an object, and a valve
Inventor: SCHAARE PETER NIVEN
IPC: G01N33/02
Filed: 2013-02-21
Abstract: A system (100) for determining a property of an object (106) comprises an inducing arrangement (102), a detector (104) and a processor. The property may be the resonant frequency of the object (106), and the object (106) may be fruit. The inducing arrangement (102) is configured to generate an impulse of fluid, such as air, and for directing the impulse of fluid towards the object to induce a physical vibration of the object (106). The detector (104) is configured to detect the physical vibration of the object (106). The detector (104) does not contact the object (106) when detecting the physical vibration of the object (106). The processor is coupled to the detector (104) for determining the property of the object (106) based on at least the detected physical vibration. Also disclosed is a reciprocating spool valve (not shown) for use in the inducing arrangement.
Patent NZ-717906-A (NZ)
Title: An anchor device
Inventor: Peter Borris Fisher
IPC: A62B35/00
Filed: 2015-03-13
Abstract: The present invention provides an anchor device, comprising a substantially planar base portion that includes a plurality of spaced apart apertures shaped to receive a plurality of fasteners and an intermediate inclined portion that extends upwardly from one side of the base portion to a substantially planar tab portion, the tab portion including an aperture that is shaped and dimensioned to receive a securing member; wherein the plurality of spaced apart apertures includes a set of apertures located centrally on the base portion and at least two sets of apertures aligned relative to one another and located at or adjacent opposing edges of the base portion. The anchor device can be used on a number of roof cladding profile.
Patent NZ-719592-A (NZ)
Title: Pyrrolo[2,1-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
Inventor: SIEGEL DUSTIN
IPC: C07H7/06
Filed: 2014-11-06
Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[2,1-f][1,2,4]triazine-4-amine compounds of Formula (I) as shown below wherein R1 is H; R2 is H or F; R3 is OH; R4 is CN; R6 is OH, their use for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[2,1-f][1,2,4]triazine-4-amine compounds. Preferred compounds of Formula (I) include, but are not limited to (2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile; (2R,3S,4R,5S)-5-(4-amino-5-fluoropyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile; ((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; ((2R,3S,4R,5S)-5-(4-amino-5-fluoropyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; S,S’-2,2’-((((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)phosphoryl)bis (oxy)bis(ethane-2,1-diyl) bis(2,2-dimethylpropanethioate); (2S)-2-ethylbutyl 2-(((((2R,3R,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; and (2S)-ethyl 2-(((((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino) propanoate.
Patent NZ-724580-A (NZ)
Title: Pipe fitting assembly
Inventor: DAVID JOHN PICTON
IPC: F16L33/207
Filed: 2015-10-07
Abstract: A problem with pipe fittings that include integral swageable collars is that it is difficult to confirm whether a pipe is fully ‘home’ on the fitting before the collar is swaged. This can lead to leaky fittings, which can remain undetected for some time, and lead to the need for costly repairs. This problem is minimised by providing a short length of thread adjacent a shoulder of the fitting, allowing the installer to feel the pipe moving fully ‘home’ on the fitting prior to swaging. This feel is achieved by the installer, by simply twisting the pipe relative to the fitting during the final stage of fitting the pipe to the fitting using a simple wrist action, as the end of the pipe engages with the short length of thread, and feeling for an increased resistance when the pipe abuts the shoulder, confirming that the pipe is fully ‘home’.
Patent NZ-736888-A (NZ)
Title: Improved anode support and or locator device and method of assembly
Inventor: JENSEN JIM
IPC: F24H9/45
Filed: 2016-02-29
Abstract: A water heater tank anode support device (100) suitable for an anode (10) having one end affixed to the wall of the tank (14). The anode support device has an upper mouth portion (140) which converges towards a lower neck portion (142), the upper mouth portion being configured to engage a second end (12) of the anode. The anode support device is operatively engaged with the base of the tank (300) by a tank engaging formation (120). Water storage tanks are often made of ferrous material prone to corrosion. Such tanks are typically protected against internal corrosion by a protective layer of vitreous enamel and a sacrificial anode. The sacrificial anode is sufficiently stiff that when fitted by its mounting point at the top of the tank, the end can deflect and crack the internal enamel coating of the tank, exposing the metal surfaces to corrosion. The provision of an anode support device limits the free movement of the end of the anode, reducing potential damage to the enamel coating of the tank.
Patent NZ-740221-A (NZ)
Title: St2l antagonists and methods of use
Inventor: DUFFY KAREN
IPC: C07K16/24
Filed: 2013-04-29
Abstract: The present invention provides an isolated human or human-adapted antibody antagonist or fragment thereof that specifically binds Domain I (SEQ ID NO: 9) of human interleukin-1 receptor like 1 (ST2L), comprising a heavy chain complementarity determining region (HCDR) 1 (HCDR1), a HCDR 2 (HCDR2), a HCDR 3 (HCDR3), a light chain complementarity determining region (LCDR) 1 (LCDR1), a LCDR 2 (LCDR2), and a LCDR 3 (LCDR3), wherein the HCDR1, HCDR2, HCDR3, LCDR1, LCDR1, and LCDR3 comprise: a) SEQ ID NOs: 95, 109, 84, 130, 90 and 131, respectively; b) SEQ ID NOs: 97, 111, 84, 130, 90 and 131, respectively; c) SEQ ID NOs: 96, 110, 84, 130, 90 and 134, respectively; d) SEQ ID NOs: 97, 111, 84, 130, 90 and 134, respectively; e) SEQ ID NOs: 97, 112, 84, 130, 90 and 134, respectively; f) SEQ ID NOs: 98, 113, 84, 130, 90 and 134, respectively; g) SEQ ID NOs: 97, 115, 84, 130, 90 and 134, respectively; h) SEQ ID NOs: 99, 116, 84, 130, 90 and 133, respectively; i) SEQ ID NOs: 100, 117, 84, 130, 90 and 133, respectively; j) SEQ ID NOs: 101, 118, 84, 130, 90 and 133, respectively; k) SEQ ID NOs: 102, 120, 84, 130, 90 and 132, respectively; l) SEQ ID NOs: 103, 121, 84, 130, 90 and 132, respectively; m) SEQ ID NOs: 103, 122, 84, 130, 90 and 131, respectively; n) SEQ ID NOs: 103, 123, 84, 130, 90 and 131, respectively; o) SEQ ID NOs: 104, 124, 84, 130, 90 and 131, respectively; p) SEQ ID NOs: 105, 125, 84, 130, 90 and 131, respectively; q) SEQ ID NOs: 106, 126, 84, 130, 90 and 131, respectively; r) SEQ ID NOs: 95, 127, 84, 130, 90 and 131, respectively; s) SEQ ID NOs: 107, 128, 84, 130, 90 and 131, respectively; t) SEQ ID NOs: 108, 129, 84, 130, 90 and 131, respectively; u) SEQ ID NOs: 24, 28, 146, 36, 40 and 147, respectively; or v) SEQ ID NOs: 24, 28, 146, 36, 40 and 44, respectively.
Patent NZ-746427-A (NZ)
Title: Control of a drug infusion device
Inventor: PACE WILLIAM BRUCE
IPC: A61M5/142
Filed: 2017-04-05
Abstract: A drug infusion device determines whether an infusion program is stored within a memory. If so, a user is prompted to confirm usage of the program and a drug identifier, and to review the configuration of the device. If the program is not in the memory, the drug infusion device is enabled to receive an auto program with which it can configure itself. When auto program receipt is enabled, the drug infusion device waits for the auto program or for a selection for manual entry of the infusion program. A menu screen is displayed to indicate that the drug infusion device is waiting for the auto program, but the menu screen is not displayed if the auto program is already received. Therefore, a waiting for auto program menu screen may be avoided in many cases, reducing device setup time. In some embodiments, removal of a drug vial resets the device to a point after a power-on self-test and thus provides an easy method for resetting the device to a point that avoids unnecessary steps and expands a window of opportunity for receiving an auto program compared to prior work flows.
Patent NZ-755855-A (NZ)
Title: Anti-garp protein and uses thereof
Inventor: LUCAS SOPHIE
IPC: A61K39/00
Filed: 2014-08-01
Abstract: The present invention relates to an IgG antibody binding to the transmembrane protein ‘glycoprotein A repetitions predominant’ (GARP) at an epitope comprising Y137, S138, and G139 of hGARP when hGARP is complexed with latent TGF-β1, wherein the antibody is an IgG antibody comprising HCDR1 of GYGIN, HCDR2 of MIWSDGSTDYNSVLTS, HCDR3 of DRNYYDYDGAMDY, LCDR1 of KASDHIKNWLA, LCDR2 of GATSLEA, and LCDR3 of QQYWSTPWT.
Patent NZ-758955-A (NZ)
Title: An agricultural system
Inventor: VERMEULEN Brecht
IPC: G06Q50/02
Filed: 2018-05-09
Abstract: A system comprising: a controller (104) configured to: receive bale-location-data (110) representative of the location of a plurality of bales (108) in a field (102); receive bale-property-data (116) representative of one or more physical properties of each of the plurality of bales (108); and determine bale-pick-up-data (112) based on the bale-location-data (110) and the bale-property-data (116), wherein the bale-pick-up-data (112) is associated with an operation to pick up the bales (108) from the field (102). The controller is configured to determine an ordered pick-up sequence based on the bale-property-data.