baber/WOPTO huggingface dataset:
Patent IL-74187-A0 (IL)
Title: Method of radioactively labeling diagnostic and therapeutic agents containing a chelating agent and a method and kit utilizing the product thereof
IPC: A61K51/12
Filed: 1985-01-29
Abstract: A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable of chelating with the radioactive metal ion, with an ion transfer material having the radioactive metal ion bound thereto and having a binding affinity for the radioactive metal less than the binding affinity of the chelating portion for the radioactive metal ion, wherein prior to contacting the chelating portion is unchelated or is chelated with a second metal having a binding affinity with the chelating portion less than the binding affinity of the radioactive metal ion, whereby a radiolabeled therapeutic or diagnostic agent is formed by the contacting, and separating the radiolabeled therapeutic or diagnostic agent from the ion transfer material, is disclosed along with various I components and kits useful in praticing this method and several variations thereof.
Patent IL-74554-A0 (IL)
Title: Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones,process for their preparation,their use veterinary drugs and process for controlling protozoa
IPC: A61P33/02
Filed: 1985-03-11
Abstract: Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula    <IMAGE>  (I)  in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl each having 1 to 6 carbon atoms in the alkyl moiety, nitro, cyano, amino, alkylamino or dialkylamino each having 1 to 12 carbon atoms in the alkyl moiety, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino having 1 to 6 carbon atoms in the acyl moiety, or (b) a phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or aniline radical which is in each case R(a)-substituted, and the alkali metal salts, alkaline earth metal salts or ammonium salts thereof, a process for their preparation, their use, veterinary drugs and a process for controlling protozoal diseases.
Patent IL-80931-A0 (IL)
Title: Fluorine-containing 1,4-dihydropyridines,their preparation and medicaments containing them
IPC: A61K31/455
Filed: 1986-12-10
Abstract: Hypotensive long-acting 1,4-dihydropyridines of the formula   <IMAGE> in which R1 is phenyl or heterocyclic, R2, R3, R4 and R5 have the usual definitions in such compounds, R6 represents hydrogen or a lower alkyl radical or the trifluoromethyl group, R7 and R8 each denote a hydrogen atom or a fluorine atom, n>/=1 and m>/=0, and the sum of n and m must be a least 4, and X represents a single bond, an oxygen atom or the group -N(alkyl)-O2S-, or pharmacologically acceptable acid addition salts thereof.
Patent IL-83206-A0 (IL)
Title: Derivatives of aminoalkylthio-triazolopyridine or triazoloquinoline,the processes for their preparation,and drugs,useful especially as analgesics,in which they are present
IPC: A61P25/04
Filed: 1987-07-15
Abstract: The present invention relates to novel compounds corresponding to the formula:   <IMAGE>   in which: n represents an integer between 1 and 8 and optimally 2 or 3; (CH2)n-N can also form a ring or a heterocycle, for example having 5 to 7 atoms and preferably 6 atoms; R1 and R2 can represent hydrogen or a lower alkyl having 1 to 5 carbon atoms or can form, together with the nitrogen, a ring such as pyrrolidine, piperidine, morpholine, thiomorpholine, phenyltetrahydropyridine, piperazine or piperazine N-substituted by an alkyl, a phenyl or a heterocycle; in the case of the phenyltetrahydropyridines and the phenylpiperazines or heteroarylpiperazines, the phenyl or the heterocycle may or may not be substituted by halogens or methoxy, thiomethyl, hydroxyl, nitro, amino, cyano, lower alkyl, trifluoromethyl or trichloromethyl groups; and R3, R4 and R5 can represent hydrogen, a lower alkyl, a hydroxyalkyl or hydroxybenzyl group, a halogen, a trifluoromethyl, a methoxy, a thiomethyl or a nitro or two of them can form a ring, in particular a phenyl in the case of the triazoloquinolines or the triazoloisoquinolines; and the non-toxic acid addition salts. These products are useful as drugs and possess analgesic properties, acting especially on the central nervous system as minor tranquilizers.
Patent IL-86326-A0 (IL)
Title: Recovery of purified,oxidized,renatured recombinant interleukin-2 from microorganisms
IPC: C07K14/52
Filed: 1988-05-10
Abstract: A process for recovering highly pure, recombinant IL-2 from transformed microorganisms in which the cells are disrupted; impure recombinant IL-2 is isolated in the form of refractile bodies from the disruptate; the impure IL-2 is dissolved and denatured with at least 6 M guanidine hydrochloride containing a reducing agent; the reduced IL-2 is precipitated and resolubilized; the reduced solubilized IL-2 therein is oxidized by a controlled oxidation in which the concentration of guanidine hydrochloride is maintained at least at 6 M; the oxidized IL-2 is refolded by reducing the concentration of guanidine hydrochloride in the solution; and the oxidized, refolded IL-2 is further purified by ion exchange chromatography or hydrophobic interaction chromatography and ion exchange chromatography.
Patent IL-89460-A0 (IL)
Title: Compositions for inducing binding between parts of mineralized tissue
IPC: A61L24/00
Filed: 1989-03-02
Abstract: Binding is induced between living mineralised tissue parts by applying a precursor to dental enamel (i.e. enamel matrix) which causes regeneration of the mineralised tissue on at least one of these parts. The enamel matrix can be obtained from pigs or cattle and is combined with a carrier, diluent or adhesive. The enamel matrix can also be obtained by recombinant DNA techniques or cultivation of diploid cells.
Patent IL-92267-A0 (IL)
Title: 2(1h)-quinolinone compounds,processes for the preparation thereof and pharmaceutical compositions comprising the same
IPC: A61P9/04
Filed: 1989-11-09
Abstract: 1. A compound of the formula : <CHEM>  wherein R<1> is imidazopyridyl, thiazolyl, indolyl, dihydroindolyl, imidazolyl, benzimidazolyl, quinolyl, isoquinolyl, quinazolinyl, dihydroisoquinolyl, tetrahydroimidazopyridyl or tetrahydroquinolyl, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, ar(lower)alkoxy, cyano, nitro, amino, lower alkylamino, acylamino, hydroxy and oxo,  R<2> is hydrogen, lower alkyl or halogen, A is a single bond or a group of the formula selected from the group consisting of :    -CO-X @, -@@-X- and -X-CO-, in which  X is a single bond or lower alkylene and X<1> is lower alkylene, and  a heavy solid line means a single or a double bond, and its pharmaceutically acceptable salt, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
Patent AU-PR222500-A0 (AU)
Title: Method for efficient scalable compression of video
IPC: H04N19/63
Filed: 2000-12-21
Abstract: A method and apparatus for producing a fully scalable compressed representation of video sequences, so that they may be transmitted over networks, such as the Internet, for example. Because the signal is scalable, users receiving the signal can obtain the signal at the appropriate resolution and quality that their system will handle or that they desire. A “motion compensated temporal wavelet transform” is implemented in order to enable compression of the video in a scalable fashion while still taking advantage of inter-frame redundancy in a manner which is sensitive to scene and camera motion. The motion compensated temporal wavelet transform is implemented by decomposing the video sequence into a set of temporal frequency bands and then applying a sequence of motion compensated lifting operations to alternately update an odd frame sub-sequence based upon an even sub-sequence and vice versa in a manner which is sensitive to motion.
Patent IL-104055-A0 (IL)
Title: Ethanol adducts of 6-sulfonyl-substituted 3-hydroxychromans and their use as inhalants in diseases
IPC: A61K9/12
Filed: 1992-12-10
Abstract: The invention relates to ethanol adducts of the compounds of the formula I    <IMAGE>  I  to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.
Patent IL-104941-A0 (IL)
Title: Indole derivatives
IPC: A61P25/20
Filed: 1993-03-04
Abstract: PCT No. PCT/US93/01667 Sec. 371 Date Aug. 19, 1994 Sec. 102(e) Date Aug. 19, 1994 PCT Filed Mar. 3, 1993 PCT Pub. No. WO93/18032 PCT Pub. Date Sep. 16, 1993   <IMAGE>  (I)  Compounds of the formula (I) where A represents a direct bond, C1-C4 alkyl, or C1-C4 alkenyl; n is 0, 1, or 2; W, X, Y, and Z are each independently oxygen, sulfur, nitrogen or carbon, provided that at least one of W, X, Y, or Z is nitrogen. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.
Patent IL-111323-A0 (IL)
Title: Growth factor heterodimers
IPC: C07K14/71
Filed: 1994-10-18
Abstract: Heterodimeric neurotrophins are prepared by mixing two homodimeric neurotrophins, subjecting the mixture to dissociation conditions, and allowing reassociation to occur so that heterodimers are formed. The heterodimers can be purified and isolated. The heterodimers are useful in the treatment of damage to the nervous system.
Patent IL-111795-A0 (IL)
Title: Improved process for the manufacture of cycloalkyl and haloalkyl o-aminophenyl ketones
IPC: B01J31/02
Filed: 1994-11-28
Abstract: There is provided an improved method for the production of o-aminophenyl ketones of formula I wherein R is C3-C6cycloalkyl or C1-C6haloalkyl. <CHEM> There is also provided an effective method for the preparation of the formula I compound o-aminophenyl cyclopropyl ketone via the dehydrohalogenation of 1-(o-aminophenyl)-4-halo-1-butanone in the presence of a base and a phase transfer catalyst. Compounds of formula I are key intermediates in the manufacture of sulfamoyl urea herbicides.
Patent IL-114570-A0 (IL)
Title: 1H-imidazo(4,5-c)quinoline compounds
IPC: A61K31/47
Filed: 1992-03-01
Abstract: Intermediates for preparing 1-substituted, 2-substituted 1H-imidazo Ä4,5-cÜ-quinolin-4-amines of formula (I) are provided where X is selected from the group consisting of alkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, alkylamido, amino or substituted amino wherein the substituent is alkyl, hydroxyalkyl, azido, chloro, hydroxy, 1-morpholino, 1-pyrrolidino, and alkylthio. The compounds of formula (I) function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. <CHEM>
Patent IL-116470-A0 (IL)
Title: Carton with reinforced handle and process for its manufacture
IPC: B65D5/46
Filed: 1995-12-20
Abstract: PCT No. PCT/FR95/01756 Sec. 371 Date Aug. 26, 1996 Sec. 102(e) Date Aug. 26, 1996 PCT Filed Dec. 29, 1995 PCT Pub. No. WO96/20874 PCT Pub. Date Jul. 11, 1996The invention pertains to a carton, a blank and a process for manufacturing a carton of sheet material. The carton includes a cover formed by inner and outer flaps, and two sinkable corner regions situated respectively on either side of the carton or of the cover, straddling the fold lines corresponding to two walls and two opposing flaps. It includes an elongate handle comprising a lower band made of a sheet material formed at least in part by a detachable part belonging to at least one outer flap and a reinforcing upper band secured to the lower band having ends fixed on each side to opposing lateral walls, underneath the sinkable corner regions with respect to the upper face of the cover. The handle encompasses or extends opposite the sinkable corner regions so that, when the handle is pulled substantially perpendicularly to the upper face of the cover, handle portions situated opposite the sinkable corner regions sink into the regions.
Patent IL-118107-A0 (IL)
Title: Method and apparatus for producing oriented plastic strap and strap produced thereby
IPC: B29C55/18
Filed: 1996-05-01
Abstract: An apparatus for simultaneously milling and stretching a sheet workpiece (122) includes a pair of opposed rollers (142, 144) defining a nip (146) therebetween and through which said sheet workpiece (122) is passed to be simultaneously milled and stretched in a single pass. The opposed rollers are driven in opposite directions and at sufficiently different lineal surface velocities to simultaneously mill and stretch the workpeice within the nip. Means (188, 194) for heating opposite side portions of the sheet workpiece (122) upstream of the nip (146) and at axial positions across its width are located predetermined distances from opposite side edge portions of the sheet workpiece. This increases the degree of flatness of the workpiece across its width after it has been simultaneously milled and stretched by eliminating any concave portions and bump transitional points defined between said concave portions and a main central portion of it. These tend to form at and within the vicinity of said axial positions located said predetermined distances from said opposite side edge portions of the sheet workpiece (122). <IMAGE>
Patent IL-137924-A0 (IL)
Title: Continuous magnetic separation of components from a mixture
IPC: B03C/
Filed: 1999-02-19
Abstract: A magnetic system and apparatus having a multi-dimensional gradient for continuous, on-line separation of components from a mixture of chemical entities which comprises at least one separation chamber with a plurality of channels and a plurality of magnets, and a method is provided for continuously and magnetically separating and treating components of a mixture of chemical entities using a multi-dimensional gradient.
Patent IL-141863-A0 (IL)
Title: A process for the preparation of 2,3,5-trimethyl-p-benzoquinone
IPC: C07C50/02
Filed: 2001-03-07
Abstract: Production of 2,3,5-trimethyl-p-benzoquinone comprises the oxidation of 2,3,5- or 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a mixture of water and an 8-11C neocarboxylic acid and in the presence of a catalyst containing one or more copper(II) salts at 50-100 degrees C.
Patent IL-145490-A0 (IL)
Title: Treatment with small peptides to effect antifibrotic activity
IPC: A61P13/12
Filed: 2000-03-20
Abstract: Methods for treating treating fibrosis in a mammal are described. An antifibrotic effective amount of a peptide having the formula f-Met-Leu-X where X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr is administered to the mammal. The fibrosis may be due to pathological changes resulting, e.g., from pulmonary fibrosis, atherosclerosis, cirrhosis, glomerulosclerosis, chronic pancreatitus, coronary artery disease (such as caused by infection by bacterium Chlamydia pneumoniae), trauma or surgical procedures. Examples of surgical procedures that cause fibrosis are post-operative fibrosis peri-neurally in the dura or nerve roots following spinal surgery, tenolysis of injured or repaired tendons with adhesions, neurolysis of damaged or repaired peripheral nerves with adhesions, post-operative adhesions from gynecologic and abdominal surgeries, reparative surgery of the vas deferens or fallopian tubes for reversal of male or female sterilization, and surgical repair of other tubular structures such as urethra, intestine or esophagus.
Patent IL-155886-A0 (IL)
Title: Use of activated coagulation factor vii for treating thrombolytic therapy-induced major bleedings
IPC: A61K38/00
Filed: 2001-12-20
Abstract: Major bleedings induced by thrombolytic/fibrinolytic therapy, including intracranial haemorrhages, are treated by administering to a subject suffering from such bleedings an effective amount of activated coagulation factor VII (VIIa) or of a functional derivative thereof.
Patent IL-159257-A0 (IL)
Title: Substituted oxazolidinones for combinational therapy
IPC: A61K45/06
Filed: 2002-06-07
Abstract: The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
Patent IL-161634-A0 (IL)
Title: Thin film capacitor using conductive polymers
IPC: H01G4/38
Filed: 2002-11-01
Abstract: The invention relates to a thin film capacitor containing (a) a substrate, (b) a first polymeric film comprising an electrically conductive polymer located on the substrate, (c) a pentoxide layer selected from the group consisting of tantalum pentoxide, or niobium pentoxide, and mixtures thereof, (d) a second polymeric film comprising an electrically conductive polymer located on the pentoxide layer.
Patent IL-185486-A0 (IL)
Title: Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
IPC: A61K39/00
Filed: 2007-08-23
Abstract: <CHEM>  Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds.  <IMAGE>
Patent IL-194483-A0 (IL)
Title: Methods for making proteins containing free cysteine residues
IPC: A61K38/22
Filed: 2008-10-02
Abstract: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
Patent IL-198922-A0 (IL)
Title: Chemical compounds and uses
Filed: 2009-05-25
Abstract: The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
Patent RO-128166-A0 (RO)
Title: Energy accumulation mechanism in a mechanical timepiece
Inventor: NAGY CSABA SANDOR
IPC: G04B13/00
Filed: 2012-08-16
Abstract: The invention relates to a mechanism for energy accumulation in the mainspring of a mechanical timepiece, which reduces the spring retensioning time, with applicability in the filed of all types of mechanical timepiece, either wrist watches or clocks, in any dimensional or aesthetic version. According to the invention, the mechanism consists of a housing () wherein there is an internal wheel (), three couples of two wheels () of different numbers of teeth, mounted on three shafts () arranged under an angle of 120° in respect of one another, an external wheel () with internal toothing (), three couples of toothed wheels () mounted on three shafts arranged under an angle of 120° in respect of one another by means of some steel retaining rings (), a piece () and a toothed wheel ().
Patent RO-128496-A0 (RO)
Title: Automatic electric system for defrosting snow from motor vehicles careening and counter-wings
Inventor: VELEA CONSTANTIN
IPC: B60R16/02
Filed: 2012-12-20
Abstract: The invention relates to an automatic electric system for defrosting snow and ice from the motor vehicles counter-wings and careening, for running in enhanced security conditions on a snow- and ice-covered roadway. According to the invention, the electric system is provided with a resistive thermal foil (), an ice-detecting sensor, a temperature sensor (), a direct current electric motor () with eccentric which is controlled by an electronic system () with micro-controller.
Patent RO-133232-A0 (RO)
Title: Linear electric generator
Inventor: MARCU EMILIAN GHEORGHE
IPC: H02K35/02
Filed: 2018-10-11
Abstract: The invention relates to a linear electric generator. According to the invention, the generator comprises an axle (1) for driving some gearing wheels (2, 3), by means of a driving belt (5), over the gearing wheels (2, 3) there being wound a magnetic cord (4), the motion of which generates an electric current in some coil units (8), the induced current being processed in an electric block (9) and converted into direct current in a rectifying bridge (10), further the current being distributed to some voltage regulators (11, 12), which limit the electric current to 12 V and 24 V, respectively.
Patent ZM-2387-A1 (ZM)
Title: Two part mailer with return envelope
IPC: B42D15/08
Filed: 1987-02-23
Abstract: The business or other institution is provided with two complementary series of blank form parts. One of these contains one or more elements of a form of construction (multiple ply, window, glassine-patched window, glue spots, patches or strips) which would make it incompatable for use with today's commercially predominate non-impact printers. The other contains none of such elements and is suited for being run through a business computer-controlled non-impact printer for the purpose of printing of variable information thereon, and of being thereafter assembled and united increment for increment with form parts from the first series, using presently available assembling and uniting apparatus, whereupon the united forms may be successively severed into thus individualized communications and dispatched to their respective addressees.
Patent LU-86438-A1 (LU)
IPC: F16K41/12
Filed: 1986-05-23
Abstract: The valve comprises a body containing a closing member with a sealing surface at the intersection of an inlet duct and an outlet duct for the passage of gas, a piston subjected to the action of a spring or the like and a control device being connected to the closing member via a pusher and via a sealing diaphragm arranged between the pusher and the piston. To lengthen the service life of the diaphragm, the diaphragm is associated with a washer comprised of a slightly deformable material.
Patent LU-86878-A1 (LU)
Inventor: JEAN-BAPTISTE SCHLEICH
IPC: E04B5/29
Filed: 1987-05-14
Abstract: Fireproof beam-column bond for reinforced concrete construction, in which the open chambers of the column profile (1, 20) are for the most part filled with concrete and the outer faces of the flanges are bare, i.e. not covered with concrete. The web and one flange of the beam (2) are bare; the other flange, supporting the concrete ceiling (8), is provided with dowels (9) which project into the ceiling. The beam (2) is fastened on both sides to fireproof columns (1) in such a way as to be tension- and compression-proof. The beam-column connection is advantageously produced by a tension strap (10) or a cover plate (12). <IMAGE>