Patent SG-11201806368V-A (SG)
Title: Halo-substituted piperidines as orexin receptor modulators
Inventor: KAMENECKA THEODORE
IPC: C07D417/14
Filed: 2017-02-10
Abstract: International Patent Classification: CO7D 403/14 (2006.01) A61P 13/12 CO7D 401/14 (2006.01) A61P 15/00 C07D 405/14 (2006.01) A61P 25/06 C07D 409/14 (2006.01) A61P 25/08 C07D 413/14 (2006.01) A61P 25/16 C07D 417/14 (2006.01) A61P 25/18 A61K 31/445 (2006.01) A61P 25/20 A61K 31/497 (2006.01) A61P 25/24 A61K 31/506 (2006.01) A61P 25/28 A61K 31/53 (2006.01) A61P 25/32 A61P 1/04 (2006.01) A61P 25/36 A61P 1/12 (2006.01) A61P 29/00 A61P 3/04 (2006.01) A61P 35/00 A61P 9/12 (2006.01) A61P 37/00 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2017/017408 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/294,940 12 February 2016 (12.02.2016) US 62/336,102 13 May 2016 (13.05.2016) US (71) Applicants: ASTRAZENECA AB [SE/SE]; SE-151 85, Sodertalje (SE). EOLAS THERAPEUTICS, INC. [US/US]; 7445 Trigo Lane, Carlsbad, CA 92009 (US). = (72) Inventors: KAMENECKA, Theodore, M.; 50 Stoney Drive, Palm Beach Gardens, FL 33410 (US). HOLENZ, Jorg; 921 Main Street, Bolton, MA 01740 (US). WESO- (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 August 2017 (17.08.2017) WIPO I PCT (10) International Publication Number WO 2017/139603 Al 111111111111110111011111111111010111110 01110111110110011111011111111111110111111 LOWSKI, Steven; 18 School Street Ext., Natick, MA 01760 (US). HE, Yuanjun; 10842 Magnolia St., Palm Beach Gardens, FL 33418 (US). BURLI, Roland; Medim- mune Limited, Aaron Klug Building, Granta Park, Cam- bridge CB21 6GH (GB). (74) Agents: VARMA, Anita et al.; White & Case LLP, 75 State Street, Boston, Massachusetts 02109 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 17 / 139603 Al (54) Title: HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS (57) : The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions con- taining them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.