Patent CA-3079029-A1 (CA)
Title: Solid forms of a compound for modulating kinases
Inventor: IBRAHIM PRABHA N
IPC: C07D471/04
Filed: 2018-10-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property Organization                                    1 11111 1 111111 11 111111 1 International Bureau (10) International Publication Number (43) International Publication Date                   WO 2019/075243 Al 18 April 2019 (18.04.2019)        WIPO I PCT (51) International Patent Classification:       GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CO7D 471/04 (2006.01)    A 61K 31/437 (2006.01)    UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A 61P 35/00 (2006.01)                           TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (22) International Filing Date:    KM, ML, MR, NE, SN, TD, TG). 11 October 2018 (11.10.2018) Declarations under Rule 4.17: (25) Filing Language:                English ¨    as to the applicant's entitlement to claim the priority of the (26) Publication Language:           English    earlier application (Rule 4.17(iii)) (30) Priority Data:                         Published: 62/572,099         13 October 2017 (13.10.2017)    US ¨ with international search report (Art. 21(3)) ¨    before the expiration of the time limit for amending the (71) Applicant: PLEXXIKON INC. [US/US]; 91 Bolivar Dri-claims and to be republished in the event of receipt of ve, Berkeley, California 94710 (US). amendments (Rule 48.2(h)) (72) Inventors: IBRAHIM, Prabha N.; c/o Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710 (US). REZA-EI, Hamid; c/o Plexxikon Inc., 91 Bolivar Drive, Berke-ley, California 94710 (US). NESPI, Marika; c/o Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710 (US).  POWELL, Ben; c/o Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710 (US). PATEL, Rashmin; c/  o Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710 (US). = (74) Agent: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, California 94301-1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: SOLID FORMS OF A COMPOUND FOR MODULATING KINASES (57) Abstract: Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridypethyl]pyrrolo [3 ,2-blpyridin-3 - yl)benzoic acid (Compound I) were Nre \r"¨C\                               prepared and characterized in the solid state: (I). Also provided are processes of manufacture and methods of using the forms of Compound I. / OH