Patent SG-11201809387Q-A (SG)
Title: Compositions and methods related to hiv-1 immunogens
Inventor: KONG LEOPOLD
IPC: C12N7/00
Filed: 2017-05-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192434 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: San Diego, CA 92109 (US). BURTON, Dennis; 6044 C07K 14/005 (2006.01) Cl 2N 7/00 (2006.01) Beaumont Avenue, La Jolla, CA 92037 (US). HE, Lin- A61K 45/06 (2006.01) ling; 4267 Robins Street, San Diego, CA 92122 (US). ZHU, (21) International Application Number: Jiang; 4267 Robins Street, San Diego, CA 92122 (US). PCT/US2017/030375 (74) Agent: FITTING, Thomas et al.; The Scripps Research In- (22) International Filing Date: stitute, 10550 North Torrey Pines Road, TPC-8, La Jolla, 01 May 2017 (01.05.2017) CA 92037 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/330,604 02 May 2016 (02.05.2016) US DZ, HR, EC, EE, EG, ES, Fk GB, GD, GE, GH, GM, GT, HN, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (71) Applicant: THE SCRIPPS RESEARCH INSTITUTE KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, [US/US]; 10550 North Torrey Pines Road, La Jolla, CA MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 92037 (US). PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (72) Inventors: KONG, Leopold; 4920 Battery Lane, #3, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Bethesda, MD 20814 (US). WILSON, Ian, A.; 1025 — Newkirk Drive, La Jolla, CA 92037 (US). DE VAL, Na- (84) Designated States (unless otherwise indicated, for every talia; 4860 Clairemont Mesa Blvd., #4, San Diego, CA kind of regional protection available): ARIPO (BW, GH, 92117 (US). WARD, Andrew, B.; 4965 Academy Street, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = _ _ (54) Title: COMPOSITIONS AND METHODS RELATED TO HIV-1 IMMUNOGENS _ - T . . _ = HR ty = _ i 1 04.... _ daavaga We — = = b 041 = \"12° ii ilit\" Rational Waldo of1191 Pktwrdinua RRI = 3.S T8Q50 A.53131 = = C = = - SIM 1 LC 1 , 11 = IOC- , , pace # Enertni Design li t ll :VI' Sta# 3 7=tg ai \"'\" 4 4 POI 3 P V IV /mat of al desi t*, ranki ns na g 71' en 71' ei cn FIG. 1 ,-1 -- -- t .., (57) : The present invention provides HiV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived - protein that harbors a modified N- terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env- derived trimer 0 protein that is presented on 8 nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for ei eliciting an immune response or treating HIV infections. [Continued on next page] WO 2017/192434 Al IMEDIMOM0101011MMEMOMOMMEHHOOMMEM1011 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))