Patent GB-896257-A (GB)
Title: Solutions, tinctures and compositions of matter for the care of teeth and mouth which contain fluorides of organic bases or amphoteric compounds
IPC: A61K8/41
Filed: 1958-07-09
Abstract: Salts of hydrofluoric acid with compounds of the formula R-X (wherein R is an alkyl, hydroxyalkyl or alkenyl radical of 8 to 20 carbon atoms, an alkyl-substituted or unsubstituted aralkyl radical containing 8 to 20 carbon atoms in the alkylene radical, or an acyl radical of a saturated or unsaturated aliphatic carboxylic acid of 8 to 20 carbon atoms and X is (NH2)x, x being 1, 2 or 3; or X is- N(R1)-(CH2)x-NR11R111, R1 and R111 being hydrogen, alkyl, alkenyl, acyl, aralkyl, cycloalkyl, hydroxyalkyl or a polyethylene glycol radical, R11 being one of these values or phenyl, and x being 1, 2 or 3, or X is a radical of the formula <FORM:0896257/IV (b)/1> R1 being hydrogen, alkyl of 1 to 20 carbon atoms, alkoxy, hydroxyalkyl, alkenyl, acyl, aralkyl or cycloalkyl; or X is -CONB2 where B is -CH2CH(R1)OH, R1 being hydrogen or alkyl of 1 to 4 carbon atoms, or one B is hydrogen, are prepared by reacting RX, either dry or in solution or suspension, with aqueous or gaseous hydrofluoric acid. Detailed examples are given.  Specifications 644,339 and 804,486 are referred to.ALSO:Solutions, tinctures and other compositions of matter for the care of teeth and mouth contain a salt of hydrofluoric acid with a compound of the formula RX, wherein R is an alkyl, alkenyl or hydroxyalkyl radical of 8 to 20 carbon atoms, an alkyl-substituted or unsubstituted aralkyl radical containing 8 to 20 carbon atoms in the alkylene radical, or an acyl radical of a saturated or unsaturated carboxylic acid containing 8 to 20 carbon atoms and X is (NH2)x, x being 1, 2 or 3; or X is -N(R1)(CH2)xNR11 R111, R1 and R111 being hydrogen, alkyl, alkenyl, acyl, aralkyl, cycloalkyl, hydroxyalkyl or a polyethylene glycol radical, R11 being one of these values or phenyl and x being 1, 2 or 3; or X is a radical of the formula <FORM:0896257/VI/1> R1 being hydrogen, alkyl of 1 to 20 carbon atoms, alkoxy, hydroxyalkyl, alkenyl, acyl, aralkyl or cycloalkyl; or X is -CONB2 where B is -CH2CH(R1)OH, R1 being hydrogen or alkyl of 1 to 4 carbon atoms, or one B is hydrogen. The compositions may take the form of tooth pastes or powders, mouth washes or chewing gum, and may contain the usual abrasives such as calcium phosphate, carbonate or sulphate, magnesium carbonate, insoluble precipitated alkaline earth fluorides, kaolines and bolus, or particularly, an oxide or ortho-or pyro-phosphate of tin or zinc. They may also contain additional surface-active substances and aroma-providing and flavouring agents.  Paste-like preparations may contain mucilages, swelling agents and softeners, and liquid preparations may consist of an aqueous or aqueous alcoholic solution of the fluoride salt containing the above mentioned additives, glycerine, sorbitol syrup and drug extracts.  Examples are given, specified active ingredients being hydrofluorides of hexadecylamine, 1-hydroxyethyl - 2 - oleoyl - imidazoline, N-hydroxyethyl - N - octadecyl - N1 - di - (hydroxyethyl) - propylenediamine, N - stearoyl - N1-diethylethylenediamine, dodecylamine, N-oleolyl - N1 - diethylethylenediamine and 12-hydroxy - 1 - amino - dodecane. Specifications 644,339 and 804,486 are referred to.