baber/WOPTO huggingface dataset:
Patent CA-2597329-C (CA)
Title: Compositions and methods involving mda-7 for the treatment of cancer
Inventor: HUNT KELLY K
IPC: A61K31/355
Filed: 2006-02-08
Granted: 2016-10-11
Abstract: The present invention concerns methods and compositions involving MDA-7 protein or an MDA-7-encoding nucleic acid in combination with either 1) a COX-2 selective inhibitor, such as celecoxib, 2) an Hsp90 inhibitor, such as geldanamycin, or a geldanamycin derivative or analog, 3) a vitamin E compound, for the treatment of cancer, 4) a TNF, such as TNF-alpha, 5) a VEGF inhibitor, or 6) an inhibitor of IL-IO. In certain examples, a treatment for breast cancer is provided. In other examples a treatment for lung cancer is provided.  Such examples involve, in some cases, an adenovirus vector that expresses MDA-7 protein.
Patent CA-2598507-C (CA)
Title: Support de tige de forage, et moitie de support de tige de forage
Inventor: FRANZEN HAKAN
IPC: E21B19/24
Filed: 2006-02-28
Granted: 2013-09-17
Abstract: Support de tige de forage (10) comprenant un système capable de déplacer deux moitiés opposées de support de tige de forage (20), chaque moitié (20) dotée d'une surface (21) de contact direct avec le train de tiges (30), ladite moitié étant par ailleurs dotée d'une cavité (23) capable de former une ouverture de train de forage (22) avec une moitié opposée de support de tige de forage (20), cette cavitéétantgénéralement en forme de V, pour le guidage de trains de tiges (30) de différentes formes et dimensions. Les moitiés de support de tige de forage (20) sont mobiles l'une par rapport à l'autre, permettant le contact avec le train de tiges (30) L'invention concerne également une moitié de support de tige de forage (20) destinée à être utilisée dans le type de support de tige de forage considéré.
Patent CA-2605202-C (CA)
Title: Stem assembly for a bicycle
Inventor: LAI WU-SHIH
IPC: B62K21/00
Filed: 2007-10-02
Granted: 2010-12-14
Abstract: A stem assembly for a bicycle has a body (10), a clamp (20) and a connecting device (30). The body (10) is connected to the bicycle between a head tube (40) and a handlebar (50) and has a handlebar mount (11) and a fork mount (12) having two hemispherical recesses (122). The clamp (20) is mounted in the body (10) and around the head tube (40) and has two jaws (21). F-ach jaw (21) is curved and has a convex hemisphere (211) corresponding to the recesses (122) of the fork mount (12) to allow an angle of the stem assembly to be adjusted. The connecting device (30) is connected to the clamp (20) and the head tube (40) and has a cap (31), a spacer (32) and a fastener (33).
Patent CA-2611920-C (CA)
Inventor: CASAR ZDENKO
IPC: C07D239/42
Filed: 2006-06-22
Granted: 2015-05-05
Abstract: A new process for preparing pure amorphous rosuvastatin calcium, substantially free of impurities, is disclosed. A process comprising hydrolysing a C1 to C5 alkyl ester of rosuvastatin, preferably methyl rosuvastatin or tert-butyl rosuvastatin, with a base, e.g. sodium hydroxide, in the presence of an aprotic solvent, preferably tetrahydrofuran and N,N-dimethyl acetamide, or in the presence of a mixture of an aprotic solvent and water, to obtain a solution of rosuvastatin salt, which may be converted to another rosuvastatin salt using another cation, e.g. with calcium cation to obtain rosuvastatin calcium. Rosuvastatin amine salts may be obtained as well. In another preferred aspect of the invention rosuvastatin free acid may be converted to various rosuvastatin salts, e.g. to rosuvastain calcium, rosuvastatin sodium or various rosuvastatin amine salts, including rosuvastatin solvates, e.g. rosuvastatin calcium hydrate. Rosuvastatin calcium is useful in the treatment of hyperlipidemia, hypercholesterolemia and atherosclerosis.
Patent CA-2613497-C (CA)
Inventor: GRIMES PATRICK G
IPC: C25B3/23
Filed: 2006-06-23
Granted: 2013-01-22
Abstract: A liquid phase process for producing hydrogen gas in a reactor comprising the step of combining at least one oxidizable reactant with liquid water and at least one alkaline electrolyte to form a mixture having a pH, wherein the pH  of the mixture is substantially maintained at a value of about 10.5 or greater and conducting a reaction in the presence of an electron transfer material that permits the movement of electrons. An alternative method produces hydrogen gas from a reaction in an electrochemical cell, the reaction characterized by an overall thermodynamic energy balance and half -cell reactions occurring at each of an anode and cathode. Energy transfers, such as thermal and electric, are analyzed and controlled in order to satisfy the thermodynamic energy balance of the reaction for efficient hydrogen production.
Patent CA-2614800-C (CA)
Title: Bacteriophage specifically for lysing propionibacterium acnes and uses thereof
Inventor: WEST DAVID
IPC: A61K35/76
Filed: 2006-07-07
Granted: 2018-10-30
Abstract: There is provided a bacteriophage capable of lysing a P. acnes bacterium and incapable of lysing a bacterium which is not P. acnes , and which is incapable of sustaining lysogeny in a bacterium. There is also provided a pharmaceutical composition comprising such a bacteriophage.
Patent CA-2616798-C (CA)
Title: Systemes et procedes destines a utiliser des plaques polyaxiales
Inventor: AUSTIN GENE EDWARD
IPC: A61B17/80
Filed: 2006-07-25
Granted: 2014-01-28
Abstract: Des modes de réalisation de la présente invention concernent un ensemble de fixation osseuse permettant d'obtenir une fixation polyaxiale. La fixation polyaxiale peut être obtenue au moyen d'ailettes s'étendant à partir d'une ouverture dans une plaque osseuse ou au moyen d'ailettes s'étendant à partir d'une tête d'un élément de fixation.
Patent CA-2619774-C (CA)
Inventor: SCHOUTEN PIETER
IPC: A61H39/04
Filed: 2006-08-18
Granted: 2013-07-09
Abstract: The present invention provides a device for applying pressure to a wearer of the device, that includes a band adapted for positioning on the wearer, an orb positioned on the band, and a mechanism for selectively varying the length that the orb extends outward from said band. The mechanism includes a dial that is mounted to the orb for user initiated selective rotation about its central axis. By rotating the dial, the orb moves towards or away from the band, thereby decreasing or increasing, respectively, the amount of pressure it will apply to the wearer.
Patent CA-2620470-C (CA)
Title: Trail receptor 2 polypeptides and antibodies
Inventor: GLINIAK BRIAN
IPC: C07K14/705
Filed: 2006-08-28
Granted: 2016-09-27
Abstract: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ("TRAIL") Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.
Patent CA-2621517-C (CA)
Inventor: GREGORY MATTHEW ALAN
IPC: C12P17/18
Filed: 2003-07-16
Granted: 2014-03-25
Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
Patent CA-2626353-C (CA)
Title: Methodes et systemes permettant a un client a sip, parmi de multiples applications a sip, de selectionner des applications et des fonctions specifiques sur un serveur a sip
Inventor: GEORGE RICHARD
IPC: H04L12/12
Filed: 2008-03-19
Granted: 2015-10-06
Abstract: On propose une méthode pour permettre à un client SIP de sélectionner une application SIP et une fonction SIP associée à lapplication SIP en envoyant un message à un serveur SIP qui comprend lidentification de lapplication SIP et de la fonction SIP. Le message peut être généré par le client SIP qui utilise les renseignements de la configuration de lapplication SIP stockés sur le client SIP. Les renseignements de la configuration SIP comprennent des renseignements sur les applications DIP et les fonctions associées et sur lendroit où se trouvent les applications SIP. Une autre méthode est proposée pour un dispositif activé par SIP, par exemple un client SIP ou un serveur SIP, à fournir avec des renseignements de configuration de lapplication SIP par un serveur de configuration. Divers dispositifs activés par SIP et un serveur de configuration pour la mise en uvre des méthodes sont également décrits.
Patent CA-2629362-C (CA)
Inventor: HERBORTH JASON TODD
IPC: F16L59/10
Filed: 2006-11-22
Granted: 2013-02-05
Abstract: A method of insulating an article (20) comprising: surrounding at least a portion of the article (20) with an insulating layer (24), inserting the article portion surrounded by the insulating layer (24) into an outer protective sleeve (26), and shrinking the outer protective sleeve (26) around the insulating layer (24).
Patent CA-2631267-C (CA)
Title: Two-sided non-stick release film
Inventor: BARNETT BRAD L
IPC: A61F13/15
Filed: 2006-11-22
Granted: 2011-12-13
Abstract: Assemblies (100) for the adhesive attachment to the skin or mucosa of a host are disclosed.  The assembly or transdermal patch includes an outer backing layer (112), a first layer of adhesive (110) on the inner surface of the outer backing layer (112), an inner backing layer (124), and an intermediate release liner (104) between the first layer of adhesive (110) and the inner backing layer (124). The intermediate release liner (104) includes a releasable surface on both its inner and outer surfaces.
Patent CA-2631442-C (CA)
Title: Vehicle control device
Inventor: TAKENAKA TORU
IPC: B60W10/18
Filed: 2006-12-21
Granted: 2011-04-19
Abstract: An FB distribution rule 20 determines an actual vehicle actuator operation control input and a vehicle model operation control input such that a difference between a reference state amount determined by a vehicle model 16 and an actual state amount of an actual vehicle 1 (a state amount error) approximates to zero, and the control inputs are used to operate an actuator device 3 of the actual vehicle 1 and the vehicle model 16. In the FB distribution law 20, when an actual vehicle feedback required amount based on the state amount error exists in a dead zone, then an actual vehicle actuator operation control input is determined by using the required amount as a predetermined value. A vehicle model manipulated variable control input is determined such that a state amount error is brought close to zero, independently of whether an actual vehicle feedback required amount exists in a dead zone. This enhances linearity of a control system and also enhances the robustness against disturbance factors or changes therein while carrying out operation control of an actuator that suits a behavior of an actual vehicle as much as possible.
Patent CA-2631678-C (CA)
Inventor: YAMAGISHI YOSHIHIKO
IPC: H02K16/00
Filed: 2008-05-16
Granted: 2018-11-20
Abstract: A electric motor is disclosed in which torque ripple is reduced. The electric motor includes a single motor shaft. Rotors are disposed so as to be mutually offset in phase, and the rotors are secured to the motor shaft. Stators are arranged so as to individually correspond to the rotors, and the stators are disposed so as to be matched in phase. The phases of torque ripple generated in each motor unit, which is comprised of a combination of a single rotor and a single stator, are offset.
Patent CA-2640410-C (CA)
Inventor: SHANKS DAVID E
IPC: H04N21/431
Filed: 2007-02-01
Granted: 2016-11-29
Abstract: The present invention discloses an interactive matrixed video channel presented on a monitor, with a plurality of individual video feeds being presented at a given time. An interactive matrixed video channel in accordance with the present invention comprises a plurality of video cells presenting at least video information, each video cell associated with one of the plurality of individual video feeds, a text box, and a control bar; wherein a command displayed on the control bar selects a screen for display on the monitor, the screen comprising information related to at least one of the video cells associated with one of the plurality of individual video feeds.
Patent CA-2644874-C (CA)
Inventor: SUTOH DAI
IPC: A61B1/06
Filed: 2008-11-25
Granted: 2012-05-08
Abstract: An instrument for confirming the position of an indwelling gastrostomy catheter, and a method of confirming the indwelling position thereof, with which it is possible to reduce cleaning costs, and which does not cause any discomfort to a patient. An instrument for confirming the indwelling position of a gastrostomy catheter which is indwelling in a hole formed between the surface of the skin of the patient and the inner surface of the stomach wall comprising a fiberscope and a protective cover. Furthermore, the tip end of the protective cover comprises a light-transmissive window part and a wire that is linked to the outer periphery at the tip end of the protective cover.
Patent CA-2645024-C (CA)
Inventor: COLTRI-JOHNSON ANDREA
IPC: B65D71/00
Filed: 2007-03-28
Granted: 2011-11-08
Abstract: A carrier package is constructed to tightly secure articles within the package. During loading, pushing the containers into the package causes the side panels of the package to deform so that the height of the package decreases and the width of the package increases.
Patent CA-2646517-C (CA)
Inventor: BLAKE RYAN
IPC: B60P7/135
Filed: 2008-12-11
Granted: 2013-03-05
Abstract: Disclosed herein is a load restraint device for a vehicle comprising a first load support bar having a first end portion and a second end portion, a second load support bar having a third end portion and a forth end portion, the first and second load support bars being joined at the second and third end portions, the second load support bar having one or more anchor portions configured to seat into a track on a surface of the vehicle to align the second load support bar with the surface, with the first load support bar oriented in an upright position, the first load support bar having a spacing section pivotally connected thereto at a pivot location, the spacing section arranged in a first upright orientation to be aligned with the first load support bar and to be located between the first load support bar and the load at a contact location, the contact location being spaced from the pivot location a sufficient distance to enable the spacing section to be pivoted from the first orientation to a second orientation wherein the spacing section is no longer between the load and the first load support bar.
Patent CA-2657374-C (CA)
Inventor: HOCHSTEIN ALLAN H
IPC: F21V21/116
Filed: 2007-07-06
Granted: 2011-09-20
Abstract: An illuminated loading dock system includes a series of light fixtures (42) having sufficient power to illuminate the interior of a series of trailers (14) from a distance that spans a dock leveler pit (26). The light fixtures are mounted to stanchions (40) (or a railing thereof) that extend upward from an elevated floor (22) that is higher than the pit's floor (24). In some cases the light fixtures are coupled to control panels (38) that control the operation of the dock levelers (30a-30d). In this arrangement, the pit floor is kept clear of clutter, and dockworkers can control the lights and the dock leveler from one safe location, as opposed to having to step down into the pit, underneath a raised dock leveler deck (32).
Patent CA-2664588-C (CA)
Title: Enantiomeric fused-pyridinone compounds with antibacterial activity
Inventor: GUILES JOSEPH
IPC: A61K31/4365
Filed: 2007-09-11
Granted: 2014-12-23
Abstract: Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.
Patent CA-2668835-C (CA)
Title: Systeme de commande de processeur d'operation duplex et methode de commande de processeur d'operation duplex
Inventor: SHIMIZU TOSHIKI
IPC: G05B19/042
Filed: 2009-06-15
Granted: 2014-01-14
Abstract: La présente invention consiste en un système de commande de processeurs de traitement duplex qui comprend des processeurs de traitement, un dispositif d'entrée-sortie, au moins une voie de communication qui relie les processeurs de traitement au dispositif d'entrée-sortie et au moins une voie de communication qui relie les processeurs de traitement entre eux. Le système de commande de processeurs de traitement duplex fait basculer l'un ou l'autre des processeurs afin qu'il soit un processeur de traitement primaire qui exécute une opération de commande pour une cible de commande, et l'autre afin qu'il soit un processeur de traitement secondaire qui est en état d'attente. Le processeur de traitement secondaire explore les données de commande de manière synchrone lorsque le processeur de fonctionnement primaire acquiert les données de commande à partir de la cible de commande.
Patent CA-2676431-C (CA)
Title: Joint de securite unitarise ameliore
Inventor: MANGONE PETER G JR
IPC: G09F3/03
Filed: 2008-12-03
Granted: 2010-10-19
Abstract: L'invention concerne un joint de sécurité unitarisé comportant une anse, un logement de mise en prise avec un passage pour recevoir l'anse, et au moins deux organes de blocage espacés le long de l'anse avec des ouvertures de gorge vers la surface externe des organes de blocage, au moins une broche étant située dans le passage de logement et orientée pour mettre en prise les gorges lorsque l'anse est avancée dans le passage pour assurer une mise en prise non amovible de l'anse dans le logement, au moins une gorge comprenant un organe cassant positionné entre son entrée et sa sortie pour mettre en prise une broche de logement de mise en prise pour résister à l'enlèvement de l'anse du logement de mise en prise jusqu'à l'application d'une force suffisante pour éloigner l'organe cassant par cisaillement.
Patent CA-2679895-C (CA)
Title: Ion mobility spectrometer comprising two drift chambers
Inventor: ATKINSON JONATHAN RICHARD
IPC: G01N27/64
Filed: 2008-02-28
Granted: 2016-08-02
Abstract: An ion mobility spectrometer has two drift chambers (11) and (12) and a common, doped reaction region (2). Each drift chamber includes an ion modifier (14) and (24), such as one that fragments the doped ions by a high electrical field. One of the drift chambers (11) is doped and the other (12) is undoped. In this way, the dopant adducts are removed by the modification process bµt then recombine with dopant only in the doped chamber.(11) so that different outputs are produced by the two drift chambers.
Patent CA-2681202-C (CA)
Title: Poudrier cosmetique avec plateau pivotant
Inventor: BOYE GAIL
IPC: A45D33/00
Filed: 2008-03-31
Granted: 2015-02-03
Abstract: L'invention concerne un poudrier pour stocker une pluralité de produits cosmétiques qui comprend un plateau pour stocker les produits cosmétiques dans un premier et un second côté ; une base ayant une paire de tiges d'articulation reçues par le plateau, le plateau pivotant dans l'articulation à partir d'une première position rendant le premier côté accessible à un utilisateur à une seconde position rendant ainsi le second côté accessible à l'utilisateur.
Patent CA-2682160-C (CA)
Inventor: SABBAH HANI N
IPC: A61F2/00
Filed: 2008-04-10
Granted: 2017-04-04
Abstract: Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of discrete masses in the heart for global resizing and reshaping may also be used as is or augmented by supplemental patterns to treat localized conditions such as myocardial infarctions and overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
Patent CA-2684187-C (CA)
Title: Interactive control of access to services and capabilities of a mobile device
Inventor: LAUER CRAIG
IPC: G06F9/445
Filed: 2008-05-01
Granted: 2013-04-09
Abstract: A system device and method are provided which determine authorization for access to one or more services grouped together as a package of services without direct intervention of a wireless network provider or wired network access provider. This offers business proprietors, contractors for telecommunication services, service resellers, OEMs and service providers the ability to authorize users, particularly users of mobile communication terminals, hereafter referred to as the Owner, access to package services. In this way a large package of features and applications can be available to a mobile device, but access to those features and applications can be controlled by the Owner thus providing the Owner with control over expenses related to accessing those features and applications. It also provides the Owner the ability to secure and prevent unauthorized access to features and applications which could allow an unauthorized user access to sensitive data and equipment.
Patent CA-2685164-C (CA)
Inventor: BENTLEY ROY
IPC: F16N31/00
Filed: 2009-11-09
Granted: 2013-07-30
Abstract: An oil pan leak guard having a wire framework, an oil absorbent material supported by the wire framework, and a washer integrated with said wire framework for receiving an oil plug and clamping the washer as the oil plug is tightened in a oil pan opening;
Patent CA-2688493-C (CA)
Title: Cycloalkylamines substitues par un phenyle en tant qu'inhibiteur du recaptage de monoamine
Inventor: SHAO LIMING
IPC: A61K31/135
Filed: 2008-06-02
Granted: 2016-04-19
Abstract: La présente invention concerne les dérivés de cyclohéxylamine substitués par un phényle ainsi que leur procédé de synthèse et leur caractérisation. L'utilisation de ces composés pour traiter/prévenir des désordres neurologiques ainsi que les procédés pour les synthétiser sont également évoqués ici. Des exemples de composés de l'invention inhibent la réabsorption de monoamines endogènes telles que la dopamine, la sérotonine et la norépinephrine (par ex. depuis la fente synaptique) et modulent un ou plusieurs transporteurs de monoamine. Les composés ayant la formulation pharmaceutique de la présente invention sont également présentés.