Patent DE-4407023-A1 (DE)
Title: Carbamoyl carboxylic acid amide derivs
Inventor: WAGNER OLIVER DR
IPC: C07C271/22
Filed: 1994-03-03
Abstract: Carbamoyl carboxylic acid amide derivs. of formula (I) and their salts are new. R<1> = 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl (each opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with T gps., 3-7C cycloalkyl or 3-7C cycloalkenyl (these cyclic gps. opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps.)); 3-7C cycloalkyl or 3-7C cycloalkenyl (these last 2 gps. each opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with 1-4C alkyl, T gps. (excluding heteroaryl) or with aryl(1-4C)alkoxy (the cyclic gp. being opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl)); a non-aromatic 4-8 membered ring contg. as ring members, in addn. to C atoms, 1 or 2 heteroatoms chosen from O, S and N (the C atoms on the ring being each opt. mono- or di-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl) and the second and any further N ring heteroatoms carrying H or 1-4C alkyl); aryl or heteroaryl (these last 2 gps. being opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (except cyclic substituents on these rings are not substd. with aryl, aryloxy or heteroaryl)); or W<1>W<2>C=N-; W<1> = 1-8C alkyl (opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with T gps. (excluding heteroaryl and alkoxy carbonyl)), 2-8C alkenyl or 2-8C alkynyl (these last 2 gps. opt. partially or completely halogenated) and opt. mono-, di- or tri-substd. with 1-4C alkyl or T gps. (except heteroaryl)), 3-7C cycloalkyl or 3-7C cycloalkenyl (these last 2 gps. opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, T gps. (excluding aryloxy and heteroaryl) or aryl(1-4C)alkyl (the aryl moiety being itself opt. mono-, di- or tri-substd. with halogen or T gps. (excluding heteroaryl))), aryl or heteroaryl (these last 2 gps. opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl)); W<2> = H or a gp. W<1>; R<2> = H, 1-8C alkyl or 3-7C cycloalkyl (these last 2 gps. each opt. partially or completely halogenated); R<3> = 1-8C alkyl, 3-7C cycloalkyl (each opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, T gps. (excluding aryl, aryloxy and heteroaryl) or phenyl(1-4C)alkyl (the Ph gp. being opt. mono-, di- or tri-substd. with halogen or T gps. (excluding heteroaryl))); R<4> = H or a gp. R<3>; or CR<3>R<4> = a 4-8 membered ring which contains as ring members, in addn. to C atoms, 1 or 2 heteroatoms chosen from O, S and N (the C atoms on the ring being each opt. mono- or di-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl) and the N heteroatoms carrying H or 1-4C alkyl); R<5> = a gp. R<2>; X = each H, 1-8C alkyl and/or 2-8C alkenyl (these last 2 gps. each opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with T gps. (excluding heteroaryl)), 3-7C cycloalkyl and/or 3-7C cycloalkenyl (these last 2 gps. each opt. partially or completed halogenated and opt. mono-, di- or tri-substd. with 1-4C alkyl, T gps. (excluding heteroaryl) or aryl(1-4C)alkyl (the cyclic gp. being opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl))); m = 0-2; A = 3-7C cycloalkyl or 3-7C cycloalkenyl (these gps. opt. partially or completely halogenated and/or opt. mono-, di- or tri-substd. with 1-4C alkyl, T gps. (excluding heteroaryl) or aryl(1-4C)alkyl (the aryl moiety being opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, T gps. (excluding aryl, aryloxy and heteroaryl) Ph or PhO)); R<6> = aryl or heteroaryl (each opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (excluding heteroaryl)); T = CN, 1-4C alkoxyalkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C alkoxycarbonyl, aryl, aryloxy or heteroaryl (the cyclic gps. being themselves opt. mono-, di- or tri-substd. with halogen, CN, 1-4C alkyl, 1-4C alkoxyalkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C alkoxycarbonyl, aryl, aryloxy or heteroaryl).