baber/WOPTO huggingface dataset:
Patent CH-501003-A (CH)
Title: 3-unsubstd 2 3 4 4a 5 6-hexahydro-1h-pyrazino 1 2-a quinolines cns act - ive
Inventor: ROSSI ALBERTO DR
IPC: C07D471/04
Filed: 1967-02-02
Abstract: Method for the preparation of 3-unsubstituted 2,3,4,4a,5,6-hexahydro-1H-pyrazino (1.2-a)quinolines (I). where R1 = nitro, amino, acylamino, hydroxyl, acyloxy, alkyl, alkoxy, and alkenyloxy, halogen, and trifluoromethyl. R2 and R3 = H or lower straight or branched alkyl. n, and p = 0,1,2, or 3. The compounds act on the CNS, in particular, they have antihypertensive activity. 250 ml acetic acid and 30ml 8N HCl in ethanol is added to a solution of 95 g 3-benzyl-8-methyl-2,3,4,4a,5,6-hexahydro -1H-pyrazino (1.2-a) quinoline in 500 ml ethanol, and the solution is hydrogenated in the presence of 4 g 10% palladium/charcoal until the theoretical amount of hydrogen is taken up. The catalyst is filtered off and the filtrate is evaporated to dryness, followed by adding ice water to the residue and 10 N NaOH solution until the mixture is alkaline. The base is extracted with dichloromethane and the organic phase is washed with water and dried on sodium sulphate. The solvent is removed to give 8-methyl-2, 3, 4, 4a, 5, 6-hexahydro-1H-pyrazino (1.2-a) quinoline, which is a yellow oil, b.p. 95-100 deg.C at 0.07 mm Hg.
Patent DK-189087-A (DK)
Inventor: TRUEMPLER WALTER
IPC: B60T8/00
Filed: 1987-04-13
Abstract: In the case of a brake for a motor, in particular an alternating current motor with a solenoid, in order to improve the dynamic characteristics without increasing the power loss it is proposed to divide the coil of the solenoid (2) into two part coils (3, 4), by means of an intermediate tap (6), one of these two part coils being located on a freewheel circuit. <IMAGE>
Patent DK-202386-A (DK)
Inventor: VITTONE ANDREA
IPC: D04H13/02
Filed: 1986-05-02
Abstract: Reticular structures comprising one or more fibrillated films perpendicularly arranged between two or more fibrillated films are prepared by a process comprising the steps of: feeding one or more fibrillated films onto a conveyor; feeding one or more transversal films perpendicularly to the conveyor feed direction; cutting such transversal films in position corresponding to the edges of the base film or films; suporposing to said transversal films one or more fibrillated films fed parallelly to the conveyor feed direction and causing the cohesion of the resulting composite structure. The device for producing such reticular structures is described too.
Patent DK-210383-A (DK)
Inventor: KIESEWETTER HOLGER
IPC: G01N11/08
Filed: 1983-05-11
Abstract: The invention concerns a measuring apparatus for checking and determining the flow shear stress of certain suspensions, principally blood, by a static or dynamic method and to thereby plot the viscosity of the suspension. The apparatus employs an internal measuring chamber comprised of a passage arrangement to simulate the natural microcirculation area wherein a network of capillary passages diverge from a main passage, with at least two of the capillary passages of different lengths, with a length ratio that can range from 3:1 to 15:1, with those capillaries connected to a source of variable pressure and extending past a detector unit.
Patent DK-276985-A (DK)
Inventor: BELANGER PATRICE C
IPC: C07D409/06
Filed: 1985-06-19
Abstract: Novel benzofuran compounds have the formula <CHEM>  in which  each R<1> is independently hydrogen or C1 to C6 alkyl;  R<2> is hydrogen, C1 to C6 alkyl, -(CH2)n -Het-Y, or <CHEM>  each R<4> is independently C1 to C6 alkyl; each R<5> is independently H, C1 to C6 alkyl, or both R<5>s join to form a 5- or 6-membered ring with the N to which they are attached; Het is a heterocyclic group selected from pyridine, pyrazine, pyrimidine, oxazole, pyrazole, oxadiazole, tetrazole, quinoline, thiophene, furan, pyrrole, thiazole, thiadiazole, or imidazole;  X is O, S, SO, SO2; Y, Y<1>, Y<2>, Y<3>, Y<4> and Z are each independently H, halogen, OH.  C1 to C6 alkyl, C2 to C6 alkenyl,  -COOR<1>, -COR<1>, nitro,  C1 to C6 alkoxy, C1 to C6 alkylthio,  -CH2SR<1>, OCH2CO2R<1>, <CHEM>  and each n is independently 0 to 10;  with the provisos that: (a) not all of R<1>, R<2>, Y, Y<1>, Y<2>, Y<3>, Y<4>, and Z are simultaneously H; (b) when up to 2 of R<1>, R<2>, Y, Y<1>, and Z are C1 to C2 alkyl, and the others of R<1>, R<2>, Y, Y<1>, and Z are H, then R<3> is not OH; and  (c) when n in <CHEM>  is O and one of R<3>, Y, Y<1>  or Z is OH, then R<1> is not H or C1 to C2 alkyl. Their phamaceutically acceptable salts are also novel. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis and are therefore useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation. The compounds are also useful as analgesics and as cytoprotective agents. They are made into pharmaceutical compositions for such uses.
Patent DK-437081-A (DK)
Inventor: LOEFFLER H P
IPC: C07F9/18
Filed: 1981-10-02
Abstract: 1. Claims for the Contracting States : BE, CH (LI), DE, FR, GB, IT, LU, NL, SE A 4-trifluoromethylphenyl (di)thiophosphate of the formula I  see diagramm : EP0049383,P15,F4  where R**1 is alkyl of 1 to 3 carbon atoms, R**2 is alkyl, haloalkyl, alkoxyalkyl or alkylthioalkyl of 1 to 6 carbon atoms, R**3 , R**4 and R**5 independently of one another are hydrogen, halogen, cyano or alkyl, alkoxy or alkylthio of 1 to 4 carbon atoms and X is oxygen or sulfur. 1. Claims for the Contracting State : AT A pesticide containing inert additives and a 4-trifluoromethylphenyl (di)thiophosphate of the formula I  see diagramm : EP0049383,P16,F4  where R**1 is alkyl of 1 to 3 carbon atoms, R**2 is alkyl, haloalkyl, alkoxyalkyl or alkylthioalkyl of 1 to 6 carbon atoms, R**3 , R**4 and R**5 independently of one another are hydrogen, halogen, cyano or alkyl, alkoxy or alkylthio of 1 to 4 carbon atoms and X is oxygen or sulfur.
Patent DK-460080-A (DK)
Inventor: MURDOCK K C
IPC: C07D219/08
Filed: 1980-10-30
Abstract: Compounds selected from the group consisting of those of the formula:   <CHEM> wherein n is the integer 1, 2 or 3; R1 and R2 are each hydrogen or methyl; R3 and R4 are the same or different and are hydrogen or straight chain or branched alkyl (C1-C4); and R3 and R4 taken together with the associated N(itrogen) is pyrrolidino, piperidino, morpholino or N-methyl-piperazino; and R5, R6 and R7 may be the same or different and are selected from the group consisting of hydrogen, fluoro, chloro, bromo and nitro; with the proviso that when n is one or two and R1 and R2 are hydrogen or methyl and R3 and R4 are lower alkyl then at least one of R5, R6 and R7 must be a substituent other than hydrogen; the pharmacologically acceptable metal complexes thereof and the pharmacologically acceptable acid-addition salts thereof. A process for their preparation and compositions of matter useful for inducing the regression of tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being certain 3,6-bis(aminoalkoxy)acridines or the pharmacologically acceptable acidaddition salts thereof.
Patent DK-571981-A (DK)
Inventor: ANNEN K
IPC: C07J5/00
Filed: 1981-12-22
Abstract: 6 alpha -methylhydrocortisones of Formula I  <IMAGE>  wherein R1 is alkanoyl of 2-6 carbon atoms or benzoyl and R2 is hydrogen or alkanoyl of 2-6 carbon atoms have valuable antiinflammatory properties.
Patent DK-595488-A (DK)
Inventor: BARMENTLOO ADRIANUS
IPC: B65F3/00
Filed: 1988-10-26
Abstract: A container (2) for a refuse lorry is divided by means of at least one horizontal partition (3) into several compartments (4,5) lying above each other. The filling openings of the compartments (4,5) are disposed on the rear of the container (2). The container (2) is provided on the rear with a rear loader (6) having a filling opening (7) and a compacting mechanism (8). The rear loader (6) has a trough (21) which is divided in by means of at least one horizontal partition (22) into several compartments (23,24) lying above one another and corresponding to the compartments (4,5) of the container (2). The compartments (23,24) connect to the filling opening (7) via slide plates (25,26). With this container (2) different types of refuse separated from each other, can be deposited each in one of the compartments (4,5) of the container (2).
Patent DK-599185-A (DK)
Inventor: OS WILLEM ARTHUR ADRIAAN ALGER
IPC: A61F6/14
Filed: 1985-12-20
Abstract: The invention comprises an assembly of an intra-uterine contraceptive device and an insertor (11, whereby the contraceptive device is provided with a central stem and two or more flexible. self-supporting arms (4); at least the said stem is accommodated in the insertor (1), and said insertor (1) is at one end, over some distance, opened to form a groove or half-cylinder (2) in such a way that the stem of the contraceptive device can be introduced and removed therefrom said half-cylinder portion ending into a knob or thickening (3).
Patent DK-607187-A (DK)
Inventor: RASMUSSON GARY H
IPC: A61K31/435
Filed: 1987-11-19
Abstract: 17 beta -Acyl-4-aza-5 alpha -androst-1-en-3-ones of the formula: <CHEM> wherein R is selected from hydrogen, methyl and ethyl R<2> is methoxy, a monovalent radical selected from straight and branched chain alkyl of from 1-12 carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents, aralkyl selected from benzyl and phenethyl and heterocyclic selected from 2- or 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl; and R', R'' and R''' are each selected from hydrogen and methyl and pharmaceutical formulations of the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism, and benign prostatic hypertrophy.
Patent DK-630088-A (DK)
Inventor: SCHEFFLER GERHARD
IPC: A61K31/50
Filed: 1988-11-11
Abstract: Azelastine embonate and pharmaceutical compositions which contain azelastine embonate as the active ingredient.
Patent FI-791565-A (FI)
Inventor: WATTS IAN SEYMOUR
IPC: A61K9/00
Filed: 1979-05-16
Abstract: Stabilised pharmaceutical formulations of prostacyclin or certain analogues thereof comprising an amino acid buffer, optionally containing a base, and the preparation of such formulations.
Patent FI-793552-A (FI)
Inventor: FRANKE ALBRECHT
IPC: C07D223/16
Filed: 1979-11-13
Abstract: Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1-H-1-benzazepin-2-one of the formula <IMAGE>   where R is alkyl of 1 to 6 carbon atoms, which is unsubstituted or substituted by hydroxyl or by alkoxy of 1 to 3 carbon atoms, or is alkenyl or alkynyl of 3 to 6 carbon atoms or is cycloalkyl of 3 to 7 carbon atoms in the ring, and their physiologically acceptable addition salts with acids, their preparation and pharmaceutical formulations, containing the said compounds, which because of their  beta -sympatholytic action can be used as cardiac and circulatory drugs.
Patent FI-842541-A (FI)
Inventor: HANSSON PER ERIC ANDERS
IPC: D21H17/55
Filed: 1984-06-21
Abstract: A product which has been formed by reacting a polymeric polyamidoamine with a polyamine of low molecular weight under reaction conditions which cause transamidation and then additionally reacting the transamidation product with a compound which is polyfunctional with regard to the amino groups which are present in the transamidation product. The resulting material can be used in paper manufacturing processes as a retention and drainage agent.
Patent FI-854395-A (FI)
Inventor: MORIARTY ANN M
IPC: C07K16/08
Filed: 1985-11-07
Abstract: Cloning and expression vectors for hepatitis B virus HBxAg, cell cultures containing these vectors and diagnostic system and method for detecting the presence of HBxAg and anti-HBxAg in body samples.
Patent FI-863924-A (FI)
Inventor: DINGERDISSEN JOHN JOSEPH
IPC: C12P21/04
Filed: 1986-09-29
Abstract: A novel subspecies of Kibdelosporangium aridum, subsp. largum (SK&F-AAD-609) produces AAD-216 antibiotics and AAD-609 antibiotics, the AAD-609 antibiotics differing from the AAD-216 antibiotics in presence of glucosamine in the glycolipid radical in place of amino glucuronic acid.
Patent FI-870976-A (FI)
Inventor: LARSSON ARNE
IPC: E05D7/12
Filed: 1987-03-05
Abstract: A fitting for mounting a turnable door blade and arranged for journally mounting the door blade in a jamb mounted hinge. The fitting has a recess (47) extending from door side to door side. In said recess there is arranged a flexible, resiliently returning tounge element (50) which has a lock shoulder (49) placed generally at the centre of the recess. The lock shoulder locks an insert element of a jamb mounted hinge and said insert element mounts the door blade in the jamb in the desired mounting manner (13). The invention also provides a unitary type of jamb long-piece (38) having easily removable covering devices (38, 39, 40) for hinge elements or lock elements (Figure 10) arranged symmetrically relative the centre of the jamb long-piece. The placement of the recesses (112) is adapted to symmetrically arranged door mounted hinge elements and lock elements. The recesses are identical as to contour - the depths thereof may be different - and the number of recesses is at least three. The hinge element (114) and the lock element form parts of units of recess contour shape, each one having an attachment part (16) attachable to a respective one of the recesses. The invention also relates to a door blade provided with a fitting of the type mentioned.
Patent FI-881089-A (FI)
Inventor: FROEIDH ARNE
IPC: A41B/
Filed: 1988-03-09
Abstract: The present invention relates to a method of folding into packages, during manufacture thereof, disposable absorbent articles such as diapers, incontinence protectors or the like provided with elastic threads (6,7). The distinguishing feature of the invention is that the article ends are folded in with approximately equal lengths over the central area of the article in question which is then folded together in the same direction into a four-folded state, the elastic portions (6',7') located in the center of the article simultaneoulsy being laterally stretched so that the article ends are laterally positioned inside said elastic portions, the folded article upon release of said elastic portions being held compressed thereby in the state of a compact, four-folded package.
Patent FI-885464-A (FI)
Inventor: MUNFORD ROBERT S
IPC: A61K39/39
Filed: 1988-11-24
Abstract: An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids form their ester linkages to hydroxy groups of 3- hydroxyfatty acids, the latter being bound in turn to LPS glycosaminyl residues. The hydrolyzed fatty acids may include dodecanoic acid, tetradecanoic acid and hexadecanoic acid. This enzyme showed a molecular weight, between 50,000 and 70,000 daltons, measured cromatographically using gel filtration. Altered bacterial LPS substantially without fatty acids bound to hydroxyl group of 3-hydroxyfatty acids covalently linked to a glucosaminyl moiety of LPS lipid A are produced. Since the structure of the lipid A moiety is highly conserved, acyloxyacyl hydrolase may act on the LPS of many different pathogenic bacteria (for example Salmonella, Escherichia, Haemophilus, and Neisseria). Such altered bacterial LPS, having toxicity reduced more than immunostimulatory activity, may be therapeutically useful: 1 as vaccines to prevent gram-negative bacterial diseases by inducing antibodies to LPS 0-polysaccharide or R-core antigens, 2 as antidotes to treat or prevent gram-negative bacterial septicaemia ("septic shock"), or 3 as adjuvants to enhance formation of antibodies to other antigens. The acyloxyacyl hydrolase itself may be prophylactically or therapeutically useful to detoxify endogenous LPS in patients with gram-negative bacterial diseases. The enzyme may also be used to remove toxic LPS from therapeutic injectants.
Patent FI-901502-A (FI)
Inventor: AHLSKOG OLOF
IPC: B66B3/02
Filed: 1990-03-26
Abstract: The invention relates to a floor and direction indicator unit for an elevator, comprising a housing with a cover panel and an indicator board consisting of a dot matrix display (3). According to the invention, the unit is provided with a microprocessor (4), in whose memory (5) the symbols (6) to be displayed on the dot matrix are stored, and with a selector (7) serving to inform the microprocessor about the operational position of the unit. <IMAGE>
Patent FI-910010-A (FI)
Inventor: BREUNIG PETER
IPC: H02K5/24
Filed: 1991-01-02
Abstract: The invention relates to an electrical machine, especially a two-pole three-phase machine, in which sprung elements (2), which are designed as separate components, and are used for attachment of the machine (1) to a foundation, are provided on both longitudinal sides of the stator housing (3). Resonances between the natural frequencies of the machine and exciting forces can be avoided, irrespective of the installation conditions of the machine, in that the feet (2) of the machine (1) itself are designed as resilient elements and are constructed resiliently in the vertical and horizontal directions in such a manner that the translation and tilting natural frequencies of both the rotor and the stator (3) are at an adequate resonance separation from the excitation frequencies occurring. <IMAGE>
Patent FI-922352-A (FI)
Inventor: HARDMAN STEPHEN
IPC: C07C1/04
Filed: 1992-05-22
Abstract: A process for the conversion of natural gas into higher hydrocarbons, which comprises the following steps:   (i) reacting natural gas with steam in at least one reforming zone containing a reforming catalyst to produce a first product stream containing carbon monoxide, carbon dioxide and hydrogen; (ii) passing said first product stream, without separating said carbon dioxide, to a Fischer-Tropsch reactor to produce a second product stream including hydrocarbons and carbon dioxide; (iii) passing said second product stream to a recovery zone where the desired higher hydrocarbon products are recovered, the remaining components of said second product stream forming a third product stream; (iv) passing at least a portion of said third product stream into the reforming zone of process step (i).   <IMAGE>
Patent FI-923239-A (FI)
Inventor: BERNER SIBYLLE
IPC: C12Q1/6816
Filed: 1992-07-15
Abstract: A method for detecting nucleic acids in which a nucleic acid probe with two or more nucleotides which are modified by immobilisable groups and which are not directly adjacent in the nucleotide sequence is used. <IMAGE>
Patent FI-933519-A (FI)
Inventor: GOTTSCHALK MICHAEL
IPC: C12N15/56
Filed: 1993-08-10
Abstract: A novel xylanase, obtained from Bacillus subtilis strains, is provided which improves the consistency and increases the volume of bread and baked goods containing it. B. subtilis DSM 7147 containing the plasmid pIK 91 produces the xylanase. Genetic engineering insertion of the gene encoding the xylanase in the plasmid pUB110 is described.
Patent FI-933740-A (FI)
Inventor: KARASIEWICZ ROBERT
IPC: A61K47/48
Filed: 1993-08-25
Abstract: The present invention relates to physiologically active water soluble polyethylene glycol conjugates with interferon and to new polyethylene glycol compounds which can be used in the preparation of the conjugates.
Patent FI-943446-A (FI)
Inventor: NIEMELAE KARI
IPC: H04B17/00
Filed: 1994-07-20
Abstract: PCT No. PCT/FI95/00403 Sec. 371 Date Mar. 18, 1996 Sec. 102(e) Date Mar. 18, 1996 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/04760 PCT Pub. Date Feb. 15, 1996For measuring the disturbance level of a base station that has at least one frequency hopping receiver and a way of measuring the signal level of signals received by the receiver, a free traffic channel is allocated. The allocated channel is caused to hop sequentially through all the frequency channels that the base station uses for reception, while signal levels of received signals are measured, and the results are transmitted to an operator. The base station also is provided with a site test and measurement unit, which is used for comparably measuring and reporting results in regard to frequency channels that the base station uses for transmission.
Patent FI-950609-A (FI)
Inventor: TURILA SAMULI
IPC: B65D19/40
Filed: 1995-02-13
Abstract: The invention relates to a load platform with a platform part 6, under which, in the area of two opposing edges of the platform surface there is a support in the longitudinal direction of the edge or a row of supports 2, 4 made up of separate supports, and a central support or row of feet 3 situated between the edge supports 2, 4 or rows of supports and essentially parallel thereto. The platform is intended for the transport and/or storage particularly of rectangular goods such as drinks crates, packs of coffee etc. The central support/row of supports 3 is lower than the outer supports/rows of supports 2, 4, so that when the platform 1 is loaded the platform part 6 is bent down at the central support/ row of supports 3, with the result that the adjacent products 5 arranged on opposite sides of the central support/row of supports 3 are supported against one another. <IMAGE>
Patent FI-961792-A (FI)
Inventor: PEET NORTON P
IPC: C07J43/00
Filed: 1996-04-26
Abstract: The present invention relates to  DELTA 16 unsaturated steroids which are useful as steroid C17-20 lyase inhibitors.
Patent FI-971479-A (FI)
Inventor: HUDKINS ROBERT L
IPC: C07D487/04
Filed: 1997-04-09
Abstract: Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed motoneuron death.. The disclosed compounds are represented by the following general formula:   <CHEM> Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.
Patent FI-972602-A (FI)
Inventor: SOLONEN VEIKKO ANTERO
IPC: B62B9/06
Filed: 1997-06-18
Abstract: The invention relates to a lifting device, which is intended for transporting and lifting loads 11. The lifting device comprises a chassis 10, wheels 12 arranged at the lower end thereof and support bars 13 of adjustable length, at the end of which are other wheels 16. The lifting device further comprises a sled 18 connected to the chassis 10 and forks 20 connected to the sled for supporting the load 10. Also connected to the sled 18 is a force-transmitting mechanism 23, 24 for moving the sled 18. According to the invention, there are articulations 21 between the sled 18 and the forks 20, which allow the forks 20 to be turned upwards. <IMAGE>
Patent FI-980418-A (FI)
Inventor: MEINANDER PAUL OLOFY
IPC: D21B1/30
Filed: 1998-02-24
Abstract: Apparatus and method are provided for treating a fluid mass or stock, particularly couch stock in paper making. Stock material is fed into a vessel having a mixing arrangement comprising rotatably arranged processing means. At lest two processing means are caused to rotate mutually adjacent in opposite direction and essentially horizontally. The stock at the upper surface of the means is conveyed towards a wall portion of the vessel, whereby spirals arranged in an inclined manner at a core of the processing means bring stock into channels defined by the core, by the spirals, and by the wall portion of the vessel, and further towards a constriction formed by the respective spiral elements running in an intermeshed manner, while a part of the stock is forced in a direction away from a discharge of the vessel.