baber/WOPTO huggingface dataset:
Patent WO-2019199621-A4 (WO)
Title: Bi-functional molecules to degrade circulating proteins
Inventor: SPIEGEL DAVID
IPC: A61K45/06
Filed: 2019-04-08
Abstract: The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are through.macrophage migration inhibitory factor (MIF) or immunoglubin G (IgG). The present invention is also directed to pharmaceutical compositions which comprise these bi- functional compounds as well as methods for treating disease states and/or conditions which are mediated through MIF/lgG or where MIF/lgG is a contributing factor to the development and perpetuation of diseases and/or conditions, especially including autoimmune diseases and cancer, among others. The purpose of the present invention is to provide a molecular strategy to lower plasma MIF/lgG level in patients with autoimmune diseases or certain types of cancers. The b.i -functional molecule construct is comprised of a MIF/IgQ-targeting motif, that is derived from small molecule MIF/lgG ligands, and an ASGPr- targeting motif that binds to hepatocyte asialoglycoprotein receptor { ASGPr). The compounds selectively bind MIF or IgG in plasma and subsequently engage the endo-lysosomal pathway of hepatocytes through ASGPr. As a consequence, MIF/igG is internalized and degraded by hepatocytes, thus resulting in potential attenuation of corresponding disease symptoms which are modulated through MIF/igG.
Patent CH-675347-A5 (CH)
Title: Table top adjustable in height and inclination - supported by two bars sliding in inclined sides of support frame and held by pin
Inventor: ARVAI TIBOR
IPC: A47B9/14
Filed: 1988-01-13
Abstract: The table top (10) is supported on two bars (15) which slide in slides in the inclined sides (11A) of a support frame (11).  Two ribs on each bar engage in grooves in the slides and the lateral surfaces of the bars and slides only come into contact when they are moved. The table's height is adjusted by putting a pin into one of a series of holes in the bars and through vertical oblong holes in the slides. The length of this hole is equal to the depth of the rib and the depth of the groove. ADVANTAGE - The height and inclination of the table top can be adjusted.
Patent CH-659062-A5 (CH)
Title: Process for in-situ coating of urea grains
Inventor: EL-GHATTA HUSSEIN DR ING-CHEM
IPC: C07C273/02
Filed: 1984-03-19
Abstract: Urea grains are treated with film-forming compounds, preferably with gaseous formaldehyde. The film thus resulting on the grains prevents the caking of the grains and increases the mechanical strength thereof, which decreases, inter alia, the troublesome development of dust when working with this substance.
Patent CH-692527-A5 (CH)
Title: Clock display dial having second hand insert with central piece/hole and cross passage sections/internal face gripping precious stones.
Inventor: FAVRE FLORIAN
IPC: G04B19/10
Filed: 1998-07-13
Abstract: The dial face has a base metal section with an opening (12) with an insert. The insert has a central piece with a hole. There are cross passages in the opening which with the internal face form gripping positions for precious stones.
Patent CH-679019-A5 (CH)
Title: PCB cleaning equipment using tank with porous tubes - connected to compressed air supply for discharging foam towards rotary cleaning brushes
Inventor: DIETHELM KARL
IPC: B08B3/00
Filed: 1989-05-25
Abstract: Two parallel, rotary, cylindrical brushes (2) underneath a printed circuit board (1) to be cleaned are supported above a shallow supply vessel (10) containing cleaning fluid. Inside the vessel a porous ceramic tube (4) is immersed in the fluid, parallel to each brush. Each tube is connected to a supply tube for air under pressure so that the fluid is converted into foam (3) which is guided towards each brush by the funnel shaped upper part (8) of a trough enclosing the tube. The air pressure can be adjusted, and connected to one end of the vessel is connected a supply line with a pump for conveying a cleaning fluid from a canister. ADVANTAGE - Compact.
Patent CH-688011-A5 (CH)
Title: Retainer for pipe conduits to be concreted into surface
Inventor: BURKHART RICHARD
IPC: E04B5/48
Filed: 1994-09-14
Abstract: The retainer comprises components for fixing the traverse (7,9) on the supports (2) at the required height. The components are formed by teeth (13,16) on the supports on the one hand and on the traverses on the other hand, together with sprung clamp pieces (20) fixed on the traverses, via which the teeth can be brought into engagement. The teeth are directed horizontally and crossways to the pipe conduit axis. The teeth on the supports have a rectangular cross-section and those on the traverses have a triangular cross-section. The clamp piece has a sprung tab (22) together with an engagement nose formation (21), by means of which the teeth on the supports and the traverses are pressed into engagement.
Patent CH-682020-A5 (CH)
Title: Sales dispensing machine for newspapers - has gripper displaced by linkage with motor input to deliver top newspaper through delivery opening
Inventor: SCHLUMPF ALOIS
IPC: G07F11/04
Filed: 1990-12-17
Abstract: A coin operated dispenser for newspapers has an enclosed housing with a front flap (2) that is displaced to allow delivery from a stack (6) supported on a suspended panel (11). The top newspaper is displaced by a gripper (31) at the end of an arm (32). The arm is coupled by a linkage system (38,45) to a motor (47). As the motor rotates the gripper is moved to push the top paper clear. When the flap is closed the papers are held by a plate. The stack is raised incrementally to maintain a reference height. ADVANTAGE - Protection against damage.
Patent CH-614116-A5 (CH)
Title: System of coupling elements for the connection of removable or fixed denture parts
Inventor: SPANG DENT HERBERT DR MED
IPC: A61C13/265
Filed: 1977-04-14
Abstract: In the system of mutually adapted coupling elements two female moulds (a1) arranged side-by-side are connected by a male mould (b1). The essential feature of this is the fact that the connection is achieved in that one male mould can be simultaneously inserted in two female moulds. The male mould can be screwed, cottered or merely inserted into the female moulds, so that the system can be used in a variety of ways in dental prosthetics depending on whether artificial crowns are to be connected to one another, to fixed denture parts or to removable denture parts. This versatility makes it possible for the system to replace individual lost teeth without the need to change previously fitted dental replacements to any considerable degree or to remove them. <IMAGE>
Patent CH-671272-A5 (CH)
Title: Support for rigid axle - has stamped slot with sprung grip around axle bar
Inventor: BUERGI ERNST
IPC: F16C35/00
Filed: 1986-11-27
Abstract: The fixed axle is gripped between two side flanges into which are stamped shaped slots (4) with one part of the slot having part circular cut-outs (1) to locate the axle. The slots are curved around the axle location to provide a sprung grip. The curved slot section leaves a narrow finger (3) holding one of the cut-outs. This provides a sprung force directed at the centre of the axle. No other fittings are required. ADVANTAGE - Simple axle fitting, pressfit fastening.
Patent CH-604645-A5 (CH)
Title: Jar mounted powdered coffee dispenser
Inventor: LAEDERACH GERALD
IPC: A47G19/34
Filed: 1976-06-15
Abstract: Jar mounted powdered coffee dispenser uses relative rotation of two identical perforated discs to deposit metered quantity
Patent CH-605312-A5 (CH)
Title: Vacuum tight oil tank seal
Inventor: HOMBERGER WALTER
IPC: B65D90/10
Filed: 1976-06-30
Abstract: Vacuum tight oil tank seal has disc with central ball against which screw cap acts
Patent CH-585329-A5 (CH)
Title: Formwork for height adjustable garage - with sidewall top section swivelling on bottom section with overlapping reinforcement sheets
IPC: E04G11/02
Filed: 1974-06-26
Abstract: The interior formwork is applied on the manufacture of prefabricated garages, or other room-sized concrete structures. The rigid displaceable support frame has a height adjustable ceiling form and end form, and extensible sidewall forms divided into top and bottom sections. The interfacing form sheets overlap their reinforcing frames and are bent back at an obtuse angle where they meet. The top form section of the sidewall form is joined to the bottom section so that it can swivel. It is in the shape of a frame with an edge-bent form sheet supported when swung outwards against the bent ends of the form sheets of the ceiling form and bottom wall section. The upper section frame may be hinged to the lower reinforcing frame, and supported on an arm.
Patent BE-1006760-A5 (BE)
Inventor: KLARL HERMANN
IPC: B67B3/00
Filed: 1990-07-25
Granted: 1994-12-06
Abstract: Une boucheuse comportant des organes de bouchage (2) pouvant être levés et abaissés, décrivant une trajectoire circulaire, et une couronne (12) les accompagnant, centrant les récipients, comporte extérieurement à la trajectoire une tuyère (1) avec une amenée de gaz inerte (19), dirigée en sens radial vers l'intérieur entre les orifices des récipients et les organes (2), avec une ouverture de sortie latérale (3) depuis laquelle le gaz entre dans les chambres d'écoulement entourant les orifices et dirigeant le gaz le long de ceux-ci puis vers l'air libre. Le dispositif d'insufflation est extrêmement simple ef efficace pour une consommation de gaz minime.
Patent BE-1013034-A5 (BE)
IPC: B44C1/18
Filed: 1999-03-23
Granted: 2001-08-07
Abstract: Production process for 3-D structural images, wherein a structural mass is first applied to an untreated or treated picture carrier, giving rise to a character in relief, after which color and other colors, solvents, pigments, water or diluting agents, if required, are applied by shaking, rinsing and skimming techniques, resulting in an art work (3-D structural image) having a realistic effect from the graphic to the abstract, which exhibits at the same time both an expressionistic and an impressionistic effect.
Patent CH-580316-A5 (CH)
Title: Record player arm needle suspension means - with crystal needle held in cylindrical tube
IPC: G11B3/46
Filed: 1974-07-24
Abstract: The record player needle comprises a crystal (1), e.g. a diamond, which is held in a cylindrical tube (5) which has a hole (6) in its side, through which the end of an arm (2) extends. The arm (2) is attached to a support which is mounted so as to follow the oscillations of the needle during playback. The arm (2) is in the form of a filiform rod, with the core formed by a metal wire, having a similar specific weight to that of aluminium, but a modulus of elasticity greater than that of piano wire. The arm (2) may be fixed to an annular permanent magnet (8) to which a ferromagnetic element (9) is glued, both being fixed in a circular sleeve (11), via a resilient collar (12).
Patent CH-616570-A5 (CH)
Title: Complete diaper of the combined disposable nappy type
Inventor: BAUMGARTNER HUBERT
IPC: A61F13/15
Filed: 1977-10-14
Abstract: The complete diaper of disposable nappy type comprises, on the one hand, a central pad (7) made from absorbent material (fluff) whose longitudinal wings (9) are folded back under the median part without their ends (10) joining up. It comprises, on the other hand, a lower layer (3) made from absorbent material, adhesively bonded directly, at several points (6), onto an outer impermeable sheet (1), the edges of which are folded back under the ends (15) of the web (14) made from nonwoven material, so as not to enter into contact with the baby's skin. It should be noted that the folded-back part of the central pad (7) is adhesively bonded directly, at two points (8), onto the lower layer (3). The spacing of the two ends (10) from the central pad (7) produces complete spreading of the liquid into the pad and directs the excess towards the central part of the lower layer (3), thus preventing propagation of the liquid as far as the edges of the diaper. <IMAGE>
Patent CH-601486-A5 (CH)
Title: Sulphonate detergent
Inventor: GRAND PAUL SHELDON
IPC: C11D3/08
Filed: 1972-08-30
Abstract: Sulphonate detergent free of carbonate and phosphate for washing clothes
Patent CH-617763-A5 (CH)
Title: Device for mounting a shelf over a radiator
Inventor: BENOIT ROGER
IPC: F24D19/06
Filed: 1977-12-13
Abstract: Device comprises two legs (1, 2) designed to be placed vertically behind and in front of a top portion (15) of the radiator, and, between these legs, an upper distance piece (3) and a lower distance piece (4) at a different height from each other and fastened to the legs by nuts (5, 8) by means of which the length of distance piece between the legs can be adjusted in order to move the lower parts of the legs towards each other. The complete device resembles a vice which can be placed on radiators of different shapes and sizes. <IMAGE>
Patent CH-601467-A5 (CH)
Title: Dispersion strengthened metals
Inventor: NADKARNI ANIL VASANT
IPC: C22C1/10
Filed: 1973-10-31
Abstract: Dispersion strengthened metals produced by internal oxidation
Patent FR-2036570-A5 (FR)
Title: Polyamides as filtration aids for precipitated metal hydrox
IPC: B01J20/22
Filed: 1969-03-25
Granted: 1970-12-24
Abstract: To precipitate easily-filterable hydroxides, esp. of Mg, Al and Fe, aqs. metal salt soln. at normal or elevated temp. is treated with aqs. soln. of sufficient basic precipitate to complete precipitation and a soln. of filtration aid comprising a high-mol. linear polymer containing acid amide groups, esp. one in which acid amide groups contain 20-50% sulphomethyl groups and which is upto 15% cross-linked with HCHO.
Patent FR-2054712-A5 (FR)
Title: Fermentation accelerator esp for bread
IPC: A21D2/22
Filed: 1969-07-24
Granted: 1971-05-07
Abstract: A compsn. for acceleration of fermentation in the making of bread, comprises ascorbic acid (20 - 35%) and amylase of fungal origin (65 - 80%). Compsn. gives improved bread structure, and better conservation properties.
Patent FR-2093547-A5 (FR)
IPC: A63C9/084
Filed: 1971-05-21
Granted: 1972-01-28
Abstract: In a releasable ski boot heel binding comprising a base to be attached to a ski, a casing having a boot heel engaging member at its front end, and a supporting member mounted to the base and pivotably connecting the casing, a cam member is swingably connected to the front portion of the supporting member. The cam member is urged and press-fitted to a transverse pin, which is connected to the front portion of the casing, by a depressing spring. The cam member has a dented portion in which normally the transverse pin engages and a protruded portion against which the transverse pin acts to force back the cam member.
Patent FR-2126820-A5 (FR)
Title: Fibreboard mfg. machine - with endless belt, heated rotating drum and at least three compression rollers
IPC: B27N3/26
Filed: 1972-02-09
Granted: 1972-10-06
Abstract: Machine for the continuous manufacture of fibreboard panels has an endless belt, on which the resin impregnated wood shavings are spread, a heated rotating drum over which the belt passes in order to compress the particles, and >=3 compression rollers whose spacing relative to the drum can be controlled, placed downstream from the initial point of contact with the drum. The dia. of the compression roller nearest to the initial point of contact is >600mm, and the dia. of the other compression rollers is >=500mm.
Patent FR-2227724-A5 (FR)
Title: Flame proof curtain for large areas - thus restricting fire to one part of area
IPC: A62C2/10
Filed: 1973-04-27
Granted: 1974-11-22
Abstract: The curtain is formed of a multiplicity of panels (1) which are articulated and are stored folded against the ceiling (3). In case of fire they are rapidly lowered to form a curtain between the ceiling and the group (2). The panels have a frame which is not deformed by fire and contains at least two plates of thermal insulating material which enclose an air space (4). The panels have gas tight hinged joints where two panels are articulated, having one part on the interior of the joint (9) and the other part (8) on the outside of the joint.
Patent DD-293241-A5 (DD)
Title: Verfahren zur umwandlung elektromagnetischer wellen in waermeenergie
Inventor: WOLF BODO
IPC: H05B6/00
Filed: 1982-04-15
Abstract: Die Erfindung bezieht sich auf die Umwandlung nach bekannten Verfahren aus Elektroenergie erzeugter elektromagnetischer Wellen des Hoch- und Hoechstfrequenzbereiches in Waermeenergie des Nieder- und Mitteltemperaturbereiches. Das Ziel der Erfindung ist ein Verfahren nach dem thermodynamischen Waermepumpenprinzip, bei dem die notwendigen Prozeszschritte gegenueber dem bekannten Stand der Technik mit deutlich geringerem Energiebedarf realisiert werden. Erfindungsgemaesz wird das erreicht, indem die mit Energie zu beladenden Gase gleichzeitig als Arbeitsmittel und Nutz- bzw. Gebrauchsenergietraeger im Prozesz verwendet werden, auf die, durch planparallel und deckungsgleich installierte, elektromagnetische Wellen des Hoch- oder/und Hoechstfrequenzbereiches ausstrahlende Flaechen, die Energie dieser Wellen durch Absorption, ohne dasz eine Resonanz der Strahlungsflaechen zu Lebewesen erforderlich ist, uebertragen wird. Das Verfahren kann zur Brennstoffeinsparung in allen Bereichen der Volkswirtschaft waehrend der Erfuellung von Energieversorgungsaufgaben, insbesondere der Waermeversorgung, eingesetzt werden.
Patent DD-228242-A5 (DD)
Title: Verfahren zur herstellung von 8-methoxy-4,8-dimethyl-1-(4-isopropyl-phenyl)-nonan
Inventor: JAVDANI KAMBIZ
IPC: C07C15/107
Filed: 1984-02-13
Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung von 8-Methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-nonan fuer die Anwendung als Insektizid, insbesondere zur Bekaempfung von Solenopsis geminata. Ziel der Erfindung ist die Bereitstellung eines verbesserten Verfahrens, mit dem die gewuenschte Verbindung auf einfache und wirtschaftliche Weise erhalten werden kann. Das erfindungsgemaesse Verfahren umfasst die folgenden Schritte:a) Reagieren von Paraisopropylbenzylchlorid mit Triphenylphosphin in Anwesenheit eines geeigneten Loesungsmittels,b)Extrahieren der so gebildeten Feststoffe mit Methanol,c)Reagieren der Paraisopropylbenzyltriphenylphosphoniumchlorid-Loesung mit Natriummethoxid und anschliessend mit Methoxycitronellal, undd)Hydrieren des cis- und trans-8-Methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-1-nonens in Anwesenheit eines geeigneten Loesungsmittels und eines Palladium-Kohlenstoff-Katalysators.
Patent DD-281649-A5 (DD)
Title: Verfahren zur verbesserung des waermeuebergangs bei kondensation in waermeuebertragern dampf/wasser
Inventor: BODE WILLI
IPC: F28F13/04
Filed: 1988-06-15
Abstract: Das Verfahren zur Verbesserung des Waermeuebergangs bei Kondensation in Waermeuebertragern Dampf/Wasser bezieht sich vorzugsweise auf das Gebiet der Waermeversorgung im kommunalen Bereich und der Industrie und ist zweckmaeszig und nutzbringend anwendbar, insbesondere bei Waermeuebertragern Dampf/Wasser, die groesztenteils im Grundlastbereich und nur relativ kurzzeitig im Spitzenlastbereich betrieben werden. Eine auf die dampfseitigen Waermeuebertragerflaechen aufgebrachte, vorzugsweise aus Fett bestehende gleichmaeszige, bestaendige und gut waermeleitende Schicht bewirkt eine Tropfenkondensation des Dampfes, die sich durch einen wesentlich besseren Waermeuebergang im Vergleich zur Filmkondensation auszeichnet und somit entweder eine Verkleinerung der Waermeuebertragungsflaechen bei gleichbleibender Leistung oder eine Leistungserhoehung bei gleichbleibender Groesze der Waermeuebertragungsflaechen ermoeglicht.{Waermeversorgung; Kondensator; Waermeuebergangsverbesserung; Fettamin; Tropfenkondensation; Spitzenlastbetrieb; Leistungserhoehung; Korrosionsbestimmung; Filmstandzeit}
Patent DD-283994-A5 (DD)
Title: Verfahren zur herstellung neuer fluortenside
Inventor: GROSS UDO
IPC: C07C211/15
Filed: 1988-11-02
Abstract: Die Erfindung betrifft die Herstellung von Gemischen neuer Fluortenside, indem ein Gemisch aus hochfluorierten H-haltigen Verbindungen mit einem Sauerstoff-Nucleophil in Gegenwart einer Base bei 30 bis 150C umgesetzt wird. Die neuen Verbindungen koennen als wasserloesliche Tenside, Emulgatoren, oelloesliche Emulgatoren usw. eingesetzt werden. Das neue Verfahren eignet sich besonders zur Reinigung inerter Fluorcarbone durch Beseitigung reaktiver H-haltiger hochfluorierter Verbindungen.{Fluorkohlenwasserstoffe; Fluortenside; Grenzflaechenaktivitaet; Tenside; Emulgatoren; Blutersatzstoffe}
Patent DD-283603-A5 (DD)
Title: Verfahren zur herstellung von substituierten hydroxylaminen
Inventor: HUEBSCH WALTER
IPC: C07D207/32
Filed: 1988-11-23
Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung von substituierten Hydroxylaminen mit inhibitorischer Wirkung auf die HMG-CoA Reduktase. Erfindungsgemaesz werden substituierte Hydroxylamine der allgemeinen Formel (I) hergestellt, worin R und R1 die in der Beschreibung und in den Anspruechen angegebene Bedeutung haben. Erfindungsgemaesz koennen die neuen substituierten Hydroxylamine durch Umsetzung von entsprechenden monosubstituierten Hydroxylaminen mit Epoxyden hergestellt werden. Die neuen substituierten Hydroxylamine koennen in Arzneimitteln verwendet werden. Formel (I){neue Verbindungen mit inhibierender Wirkung der Cholesterolbiosynthese; Anwendung als Arzneimittel}
Patent DD-281175-A5 (DD)
Title: Vorrichtung zum belueften von sauerstoffzehrenden stoffstroemen
Inventor: VETTERLEIN GUENTER
IPC: C02F7/00
Filed: 1989-04-10
Abstract: Die Erfindung betrifft eine Vorrichtung zum Belueften von sauerstoffzehrenden Stoffstroemen. Sie kann insbesondere in Anlagen zur Reinigung von verunreinigtem Abwasser, in Anlagen zur Fischaufzucht und in Anlagen zur Guelleaufbereitung eingesetzt werden. Ziel und Aufgabe der Erfindung ist es, die die bei Belueftungskreiseln in Turbinenbauform auftretenden Inhomogenitaeten zu ueberwinden, die Sauerstoffeintragsleistung und damit die Phasengrenzflaeche zwischen Fluessigkeit und Luft durch Druckverminderung zu erhoehen und ein Luftdefizit in der Kernzone des Belueftungskreisels zu vermeiden. Erfindungsgemaesz wird dies geloest, dasz der Belueftungskreisel mit einem Axialverdichter zur Vorverdichtung, der in die Phasengrenzflaeche einzubringenden Umgebungsluft, gekoppelt wird.{Belueftungskreisel; Axialverdichter; Abwasserreinigung; schaufelkanalaehnliche Leitbleche; Sauerstoffeintrag; Phasengrenzflaeche}
Patent DD-285403-A5 (DD)
Title: Verfahren zum anfahr- und stuetzbetrieb von stationaeren wirbelschichtfeuerungen
Inventor: BOESE DETLEF
Filed: 1989-06-29
Abstract: Die Erfindung betrifft ein Verfahren zum Anfahr- und Stuetzbetrieb von stationaeren Wirbelschichtfeuerungen, die mit grubenfeuchter Rohbraunkohle und insbesondere mit grubenfeuchter salzhaltiger Rohbraunkohle bzw. feuchten Abprodukten, wie zum Beispiel Klaerschlamm, betrieben werden. Das Verfahren ist dadurch gekennzeichnet, dasz die Bettmasse auf etwa 250-300C aufgeheizt wird, dann ein bei dieser Temperatur zuendender Trockenbrennstoff ueber einen separaten Brennstoffeintrag direkt in die Wirbelschicht gegeben wird bis die Zuendtemperatur des Hauptbrennstoffes im Bereich von etwa 600-700C erreicht ist, bei der die Einspeisung des Hauptbrennstoffes beginnt und bei deren Unterschreitung waehrend des normalen Betriebes der Wirbelschichtfeuerung die Trockenbrennstoff-Zuendfeuerung als Stuetzfeuerung betrieben wird. Durch das fruehe Abschalten der Heiszgaszufuhr wird OEl und Gas eingespart und fuer die mit einem festen Brennstoff betriebene Zuend- und Stuetzfeuerung ist keine Brennstaubqualitaet erforderlich. Figur{Wirbelschichtfeuerung, stationaer; Anfahren; Stuetzbetrieb; OEleinsparung; Gaseinsparung; Hauptbrennstoff; Rohbraunkohle, grubenfeucht; Rohbraunkohle, salzhaltig; Zusatzbrennstoff}