baber/WOPTO huggingface dataset:
Patent UY-28821-A1 (UY)
Title: Hidrocloruro de (4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il)-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos.
Inventor: SLEDESKI ADAM W
IPC: C07D409/06
Filed: 2005-03-23
Abstract: Compuesto que contienen hidrocloruro de (4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il)-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona, de fórmula (I) o un profármaco, sal farmacéuticamente aceptable o solvato de dicho compuesto. Composiciones farmacéuticas que comprende una cantidad farmacéuticamente eficaz del compuesto de fórmula I, y un vehículo farmacéuticamente aceptable. Se divulgan los usos de un compuesto de fórmula I como un inhibidor de triptasa, y su utilidad para tratar una afección fisiológica, que necesita la mejora de un inhibidor de triptasa. La presente invención se refiere a la preparación de un compuesto de fórmula I. que comprende una cantidad farmacéuticamente eficaz del compuestos de fórmula I, y un vehículo farmacéuticamente aceptable. Se divulgan los usos de un compuesto de fórmula I como un inhibidor de triptasa, y su utilidad para tratar una afeccíón fisiológica, que necesita la mejora de un inhibidor de triptasa. La presente invención también se refiere a la preparación de un compuesto de fórmula I.
Patent UY-28980-A1 (UY)
Title: Plaguicidas
Inventor: WERNER KNAUF
IPC: A01N43/56
Filed: 2005-06-23
Abstract: La invención se refiere a derivados polares de 5-aminopirazol-carbamato de fórmula (I) o sales de los mismos: en la cual los diversos símbolos son como se define en la descripción, a procesos para su preparación, a composiciones de los mismos, y a su uso para la represión de plagas (con inclusión de artrópodos y helmintos).
Patent UY-29265-A1 (UY)
Title: Compuestos de 3h-oxazolo y 3h-tiazolo(4,5,-d)pirimidin-2-ona 3,5- disustituidos y 3,5,7-trisustituidos y sus profármacos
Inventor: WEBBER STEPHEN E
IPC: C07D413/12
Filed: 2005-12-20
Abstract: La invención se refiere a compuestos de 3H-oxazolo y 3H-tiazolo(4,5-d)pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y sus profármacos que tienen actividad inmunomoduladora. La invención también se refiere al uso terapéutico o preventivo de tales compuestos y composiciones farmacéuticas que los contienen y a los métodos para tratar las enfermedades y trastornos descritos en la presente, por medio de administración de cantidades efectivas de tales compuestos y profármacos.
Patent UY-29653-A1 (UY)
Title: Nuevos anticuerpos anti-madcam
Inventor: PULLEN NICHOLAS
IPC: A61P29/00
Filed: 2006-07-06
Abstract: La invención proporciona nuevos anticuerpos anti-MAdCAM mejorados. También se incluyen usos de estos anticuerpos en medicina, en particular para el tratamiento de estados inflamatorios tales como enfermedad inflamatoria del intestino.
Patent UY-30613-A1 (UY)
Title: Composicion oral sin sabor metalico comprendiendo pirofosfato y citrato de cobre, proceso de preparacion y aplicaciones
Inventor: KABARADJIAN CATHERINE
IPC: A23L27/00
Filed: 2007-09-27
Abstract: La presente invencion se refiere a una nueva composicion oral sin sabor metálico que comprende una fuente de hierro y/o una fuente de cobre, a su proceso de preparacion y a su uso para equilibrar la provision de hierro como complemento nutricional.
Patent ES-180598-A1 (ES)
Title: UN PROCEDIMIENTO DE OBTENCIoN DE NITRATO AMONICO
IPC: C01C1/18
Filed: 1947-11-22
Abstract: Procedimiento para la obtención de nitrato amónico caracterizándose porque se emplea una mezcla de cien partes de nitrato amónico y 0 01 hasta 1 0 partes de "Magenta Ácida" según índice de color nº 692
Patent ES-183998-A1 (ES)
Title: PROCEDIMIENTO PARA LA FABRICACIoN DE LAS MECHAS IMPERMEABLES NO DETONANTES.
IPC: C06C5/00
Filed: 1948-06-05
Abstract: Procedimiento para la fabricación de las mechas impermeables no detonantes, adecuadas para voladuras y operaciones análogas y, más especialmente, en las mechas de seguridad, de la clase en que el núcleo de material autocombustible está encerrado en una envoltura protectora y constituido por un cuerpo en forma de varilla imporosa y compacta de una composición termoplástica homogénea obtenida por expulsión, caracterizados porque dicho núcleo incluye nitropoliestireno de un contenido de nitrógeno de 9,4 a 14, 4% aproximadamente y tiene un punto de reblandecimiento comprendido entre 60º y 200ºC, y está en forma plastificada, y en el mismo y en toda su masa se distribuyen uniformemente agentes oxidantes y reductores, normalmente pulvurulentos, siendo la proporción de nitropoliestireno plastificado, suficiente para que dicha composición tenga una consistencia adecuada para la expulsión entre 60º y 200ºC e insuficiente para impedir la propagación continua de la combustión a través del núcleo.
Patent ES-184026-A1 (ES)
Title: PERFECCIONAMIENTOS EN LOS PORTALáMPARAS PARA LáMPARAS ELÉCTRICAS TUBULARES, CON DIENTES DE CONTACTO PROYECTADOS AXIALMENTE
Filed: 1948-06-08
Abstract: Perfecionamientos en los portalámparas para lámparas eléctricas tubulares, con dientes de contacto proyectados axialmente, que se caracteriza por comprender un cajetín aislante, moldeado de una sola pieza, con una cavidad en él y que tiene una acanaladura, en su extremo superior, que prolonga una abertura circular en el frente del cajetín; un chasis aislante introducido en la cavidad y provisto de entrantes; muelles de contacto con partes abolsadas, fijos en los citados entrantes del chasis; un soporte del tubo, provisto de una ranura para recibir y contener los dientes del mismo, introducido en el cajetín por la abertura y montado giratorio entre las partes abolsadas de los muelles de contacto; láminas finales dispuestas en dicho soporte, de las que la exterior es capaz de llenar la abertura del cajetín; estando el cuerpo de dicho soporte formado por proyecciones, dispuestas diametralmente, en el plano de intersección con el de la ranura del soporte y capaz de moverse en los abolsamientosde los muelles de contacto, teniendo dicho cuerpo una longitud igual a la anchura de los muelles de contacto, para prevenir desplazamientos axiales de dicho soporte, con lo que dicho soporte, sostenido en un pivote dentro de la abertura del cajetín, sirve como único dispositivo par cerrar dicho cajetín y el chasis de los muelles de contacto en él introducidos, en colaboración con dichos muelles y fijos en el mismo.
Patent ES-196199-A1 (ES)
Title: UN PROCEDIMIENTO PARA CACINECIoN, LA CALCINIFICACIoN Y SINTERIZACIoN
Filed: 1951-01-19
Abstract: Procedimiento para la calcinación o calcinación y sinterización caracterizado porque carbonatos de alcalino-térreos u otros carbonatos o rocas hidratadas con punto de fusión similar se tratan en alturas de capas superiores a 1 m por ejemplo de 1 a 3 metros después de encender la mezcla según el método de insuflación
Patent ES-197296-A1 (ES)
Title: Perfeccionamientos en la fabricacion de plantillas para el calzado
Filed: 1951-04-06
Abstract: Perfeccionamientos en la fabricación de plantillas para el calzado caracterizados por el prensado con interposición de un aglomerante en caliente o en frio de planchas o trozos superpuestos de recortes de tela colocados de manera que se corresponden con la forma definitiva de la plantilla.
Patent ES-199835-A1 (ES)
Title: UN PERFECCIONAMIENTO EN LA FABRICACIoN DE TERMINALES PARA RADIORRECEPTORES Y SIMILARES
Filed: 1951-10-03
Abstract: Un perfeccionamiento en la fabricación de terminales para radiorreceptores y similares, que esencialmente consiste en terminar uno de sus extremos en dos aletas laterales formando una T, entre las cuales queda una pequeña muesca, dando a las mismas una pequeña convexidad en el centro de la cual queda un refundido cilíndrico. Dichas aletas con la convexidad y el refundido son dobladas en una fase posterior perpendicularmente al cuerpo del Terminal, con lo que en el extremo superior de éste y merced al relieve queda formada una cavidad cilíndrica en la que encaja perfectamente y queda retenida la clavija de la válvula.
Patent ES-201462-A1 (ES)
Title: Improvements in moulded packing units for the protection of goods in transport and when stored
IPC: B65D65/38
Filed: 1952-01-16
Abstract: A moulded packing unit which is resilient and permeable by air is made of lightly compressed woodwool, wood shavings, shredded wood, cereal straw, hay, dried grass, or flax rug which is flax mechanically broken down, or a mixture of two or more of these materials, held together by a thermosetting adhesive. Wood wool sprayed with synthetic resin, e.g. of the phenol formaldehyde or urea formaldehyde type, using for example 1/2 lb. resin to 3 1/2 lbs. wood wool, is evenly distributed between a central perforated pattern, of the shape of the portion of the article to be enclosed by the packing unit, and external perforated platens. The platens are pressed at about 45 lbs./sq. in. to consolidate the material and hot compressed air (pressure about 1 lb./sq. in., temperature 210-230 DEG F) is passed through the central pattern and the moulded material therearound, causing the resin to set. An article may be protected by a two part packing unit. A filler such as wood chips or sawdust up to about 50 per cent. by weight of the moulding material such as cardboard or fabric may be placed in the wood wool while it is being distributed round the pattern prior to moulding under pressure.
Patent ES-260356-A1 (ES)
Title: New epoxide compounds
IPC: C08G59/24
Filed: 1960-08-12
Abstract: The invention comprises epoxide compounds of the formula: <FORM:0950285/C2/1> in which R1 and R2 represent methyl groups or hydrogen atoms and n=1 or 2. The novel compounds may be made by treating a compound of the formula: <FORM:0950285/C2/2> with a dehydrohalogenating agent to convert the halohydrin group to a 1:2 epoxide group and, if desired, epoxidising the carbon-to-carbon double bond in the cyclopentene ring, in any desired order of succession. As dehydrohalogenating agent, a strong alkali, such as sodium hydroxide or potassium hydroxide, is suitable. The double bond may be epoxidised with an organic per-acid such as peracetic, perbenzoic peradipic or monoperphthalic acid. Alternatively, the compound may be treated with hypochlorous acid followed by strong alkali. The starting materials of formula II may be made either (1) by an additive reaction of a monohalohydrin: <FORM:0950285/C2/3> where Hal is halogen, for example bromine or chlorine, with dicyclopentadiene in the presence of an acid catalyst or of a Lewis. acid, such as sulphuric acid or boron fluoride or a boron fluoride complex or (2) by condensing an epihalohydrin of the formula: <FORM:0950285/C2/4> with dihydrodicyclopentadiene -8- ol. Detailed examples are given.ALSO:Curable mixtures comprise diepoxides of the formula: <FORM:0950285/C3/1> in which R1 and R2 represent methyl groups or, preferably, hydrogen atoms and n is 2 or a curing agent for epoxide compounds, e.g., an amine or amide, anilene-formaldehyde resin, urea-formaldehyde resin, melamine-formaldehyde resin, polymer of aminostyrine, polyamide, isocyanate, isothiocyanate, polyhydric phenol, phenol-aldehyde resin, oil-modified phenol-aldehyde resin, reaction product of an aluminium alcoholate or phenolate with a compound of tautomeric reaction, a Friedel-Crafts catalyst, phosphoric acid, or preferably a di- or polybasic carboxylic acid or anhydride thereof. An accelerator such as a tertiary amine or polyhydroxy compound may also be added. The curable mixtures may also contain a proportion of the above epoxide compounds whose epoxide groups are wholly or partially hydrolysed and as active diluents, mono-epoxides. Further polyepoxides such as mono- or polyglycidyl ethers of mono or polyalcohols or phenols, polyglycidyl esters of polycarboxylic acids, and aminopolyepoxides. Fillers, plasticisers or colouring matters may also be added, e.g., asphalt, bitumen, glass fibres, mica, quartz meal, cellulose, kaolin, silicic acid or metal powders.
Patent ES-267249-A1 (ES)
Title: New pyrazolo-pyrimidines and process for the preparation thereof
Filed: 1961-05-09
Abstract: The invention comprises a pyrazolo [3,4-d] pyrimidine of the formula <FORM:0937724/IV(a)/1> or a tautomer thereof, in which R1 represents a hydrogen atom or an alkyl, hydroxyalkyl, oxaalkyl, cycloalkyl, cycloalkylalkyl or aralkyl group or at most binuclear aryl or heterocyclic group, R3 represents a hydrogen atom or a lower alkyl group, and R6 represents an aralkyl group, salts thereof, pharmaceutical compositions thereof, and a process for the manufacture of compounds of the above formula wherein a 2-R1-3-amino-5-R3-pyrazole-4-carboxylic acid ester is reacted with a carboxylic acid of the formula R6-COOH in the form of its amide or nitrile or a 2-R1-3-amino-5-R3-pyrazole-4-carboxylic acid amide is reacted with a carboxylic acid of the formula R6-COOH in the form of its anhydride, or amide, or with a corresponding halide or nitrile. When R6 represents aralkyl, the phenyl nucleus may be mono-, di-, or tri-substituted by chlorine, methoxy, methylenedioxy, methyl, trifluoromethyl, amino or nitro groups. In a similar manner R1 may represent substituted phenyl. In a modification of the above process 2-R1-3-amino- 5-R3- pyrazole- 4-carboxylic acid amide is replaced by the nitrile, reacted with the derivative of the acid R6,COOH, converted into the amide followed by ring closure. Intermediate compounds having the formula: <FORM:0937724/IV(a)/2> are obtained by eliminating water from 2-R1-3-(R6-CONH)-4-carboxy-pyrazoles, e.g. with acetic anhydride. These compounds may be reacted with ammonia to obtain the acid amide. 2-(b -Hydroxyethyl)- 3-amino-4-carbethoxypyrazole is obtained by heating ethoxymethylene cyanoacetic ester with b -hydroxyethyl hydrazine. 2-[11-Ethoxy-butyl-(31)] -3-amino-4-carbethoxy pyrazole is obtained by heating ethoxymethylene cyanoacetic ester with 1-ethoxy-butyl-(3)-hydrazine. 2-a -Pyridyl-3-amino- 4-carbethoxy-pyrazole is obtained by heating ethoxy-methylene-cyanoacetic ester with 2-hydrazino-pyridine. 2-Isopropyl-3-[a -ethoxyb -(p-chlorophenyl) -ethylidene-amino]-pyrazole-4-carboxylic acid amide is obtained by forming the imino ether hydrochloride from p-chlorobenzyl cyanide and dry HC1 and boiling this with 2-isopropyl-3-amino-4-carbonamido pyrazole. 2-Isopropyl-3-(p-chloro-phenyl-acetylamino)-4-pyrazole-carboxylic acid nitrile is obtained by reacting 2-isopropyl-3-amino-4-cyano-pyrazole with p-chloro-phenylacetic acid chloride. 2-Isopropyl-3- (p-chlorophenyl-acetylamino)-4-carboxy-pyrazole is obtained by reacting p-chlorophenylacetic acid chloride with 2-isopropyl-3-amino-4-carboxy pyrazole. 1-Isopropyl-4-oxo- 6-(p-chlorobenzyl)-pyrazolo-[3,4-d] oxazine is obtained by heating 2-isopropyl-3-(parachlorophenyl-acetylamino)-4-carboxy-pyrazole with acetic anhydride. p Said compositions containing compounds of the first mentioned formula and having coronary-dilating action are administered as tablets or dragees or in liquid form as solutions, suspensions or emulsions. Specifications 937,725 and 937,726 are referred to.
Patent ES-296461-A1 (ES)
Title: The stretching of polyolefinic fibres
IPC: D02J1/22
Filed: 1964-02-14
Abstract: In a process for stretching polyolefin fibres, the fibres are subjected to a temperature gradient of 30-1200 C. by contact with a heating plate while being stretched. The fibres, e.g. polypropylene, may be in the form of monofilaments, multi-filaments or roving for staple. The highest temperature to which the fibres may be subjected is the fibre melting- point. The stretch ratio may be 1: 2 to 1 : 10. Apparatus for the process comprises a heating plate between first and second rollers, the plate containing heating elements asymmetrically distributed therein. The heating plate may be convex, flat or grooved and formed of, e.g. stainless steel or iron. The heating elements may be electric coils or tubes containing hot fluid.
Patent ES-338195-A1 (ES)
Title: Improvements in or relating to air filters
IPC: F02M35/024
Filed: 1967-03-18
Abstract: An air filter for an I.C. engine intake comprises an annular pleated paper element 3 in a two-part housing 1, 2 of injection-moulded polypropylene, having an outlet 8 and an inlet tube 23 secured to annular inlet boss 12 in part 1 by a snap-action fastening. In Fig. 1, tube 23 is polypropylene and has a peripheral ridge 25 and a flange 26 which respectively snap into annular groove 24 and abut the end of inlet boss 12 when tube 23 is pushed into boss 12. Figs. 2 to 5 (not shown) illustrate steel inlet tubes. In Fig. 2, two semi-annular polypropylene mouldings are fitted on to the tube end, by their lugs (30) engaging holes (31), to form a collar (29) which is then pushed into and engages inlet boss (28) as in Fig. 1. In Figs. 3, 4 the tube is in two parts secured along longitudinal flanges and has an outwardly turned end lip which snaps into a recess in the inlet boss directly or is retained therein by a snap action ring (43) inserted from within the housing. In Fig. 5 a peripheral ridge (45) on tube (44) abuts the end of the boss and a snap action external clamping ring (49) holds it in place. The two parts of the housing may be secured by snap action, inturned lip 19 of lid 2 engaging recess 18 of body 1 when pushed over tapering rim 13. The housing is secured to a carburetter by a stud 20 and wing-nut 21, which may constitute additional or sole means of securing parts 1, 2 together. The inlet tube acts as a silencer.
Patent ES-340393-A1 (ES)
Title: A Method of Reading Photographic Dosimeters and Apparatus for Carrying Out this Method
IPC: G01T1/08
Filed: 1967-05-11
Abstract: A method of reading a dosimeter of the kind comprising a film, which is coated with a number of photographic emulsions of different sensitivities and which, during exposure to ionizing radiation to be evaluated, is located behind a number of filters of different known absorption coefficients, said filters defining different fields or areas on the emulsions, the method comprising, for each emulsion, measuring the illumination values of a photometer by light from each area of the film (i.e. due to the optical density of the developed film) and, for each area, multiplying the inverses of the illumination value by a factor dependent on the absorption coefficients of a reference filter which covered a reference area of the film during exposure and of the filter which covered the area under consideration to obtain a modified value which is used to read the radiation dose from a stored calibration curve for the reference area. In the arrangement shown in Fig. 4 for examining a film having three emulsions exposed through seven filters, a photometer head 1 picks up light affected by the optical density of a developed exposed film and the signal is, in circuit 2, inverted and passed through a first integrator, a threshold circuit and a second integrator, all detailed in Fig. 6 (not shown). Initially, light from a reference area of the film is considered and the calibration curves of inverse illumination valves (photometer signals) against dose, stored in comparator devices 6 for each of the three emulsions. Then reading of the doses received by one emulsion commences, the appropriate channel 4, 5, 6 being switched into circuit. In device 4, the effect of background fogging is removed from the signal. In device 5, the signal is multiplied by the above-mentioned factor so that the modified photometer signal may be compared with the stored reference calibration curve to read out the dose. There may be facility in the device 6 for compensating for non-linearity of the calibration curve.
Patent ES-342571-A1 (ES)
Title: Free radicals of the nitroxide type
IPC: C07D451/14
Filed: 1967-07-03
Abstract: The invention comprises nitroxides of azabicyclic compounds in which one of the bridges comprises solely the imine radical and the preparation thereof by oxidizing the imine with phosphotungstic acid and hydrogen peroxide. Examples relate to the oxidation of aza-9- bicyclo[3.3.1]nonan - 3 - one to aza - 9 - bicyclo- [3.3.1] - nonan - 3 - onoxyl - 9 and aza - 9- bicyclo[3.3.1]nonane to aza-9-bicyclo[3.3.1]nonanoxyl-9. Aza - 9 - bicyclo[3.3.1]nonan - 3 - one is prepared by condensing 2-ethoxy-3,4-dihydro-2H- pyran with dicarboxylic acid acetone and ammonium chloride. Aza-9-bicyclo[3.3.1]nonane is obtained by hydrazine reduction of the 3-one.
Patent ES-349413-A1 (ES)
Title: Laminate housing for electrical contacts or the like
IPC: H01R13/514
Filed: 1968-01-17
Abstract: A housing for electrical contacts 20 comprises a top section 12, a bottom section 14, and a plurality of intermediate sections 16, apertures 34 in the sections providing a passageway for an N-shaped clip 42 which has an integral strap connecting two parallel, resilient legs 44 with projections 50 for engaging shoulders 40 in the apertures 34 of sections 14 and 16, and with flanges 48 which extend beyond sections 12 and 14 to hold the sections together. Sections 14, 16 have a plurality of transverse, parallel channels 17 with shoulders 26, 24 which engage respectively the end 21 and an integral lance 22 of a socket contact 20, which may be removed from the housing by depressing the lance 22 with a tool 32 passed through a slot 30. The sections are chamfered at 28 to form lead-ins for plug-contacts, e.g. on a printed circuit board.
Patent ES-352146-A1 (ES)
Title: Process for fabricating monolithic circuits having matched complementary transistors and product
IPC: H01L27/06
Filed: 1968-03-29
Abstract: An integrated circuit e.g. as shown in Fig.. 1 comprises an epitaxial layer on a substrate 12 of the opposite conductivity type with a plurality of diffused isolation rings 38 extending to the substrate and defining pockets in which complementary bi-polar transistors 28, 30 are formed. The collector 32 of one transistor 30 is formed by one isolated part of the epitaxial layer and the base 34 and emitter 36 by diffused inclusions therein, while the collector 22, base 24 and emitter 28 of the complementary transistor 20 are constituted by nested diffused regions in another isolated pocket. The Fig. 1 arrangement which also includes PN junction capacitor 40 is formed by the following steps: (1) N + inclusions 14-16 10 deep are formed in the silicon substrate and the 10 Á epitaxial layer deposited over them (2) isolation rings 38, collector region 22 and region 42 are formed by a masked diffusion step (3) N-type base region 24 is diffused (4) P-type base region 34 is diffused (5) P-type emitter region 28 and the P + region 46 of the capacitor are formed in a common diffusion (6) N-type emitter 36, base contact region 26 and the N + region 46 of the capacitor are formed in a common diffusion step. The zones of the alternative structure shown in Fig. 7 are formed by diffusion steps in the sequence (1) collector region 116 and capacitor region 142 (2) isolation rings 106 (3) collector region 124 and diode anode region 130 (4) base region 118 (5) junction isolated P-type resistor region 134 (6) base contact region 119, emitter region 126, diode cathode contact region 132 and capacitor region 146 (7) emitter region 120, base contact region 125 and capacitor contact region 144. Details are given of the diffusion steps which involve oxide masking and predeposition from boron tribromide and phosphorus oxychloride respectively.
Patent ES-355004-A1 (ES)
Title: Hot box detector for railway rolling stock
IPC: B61K9/06
Filed: 1968-06-14
Abstract: A hot axle box detector for a railway comprises an indium antimonide photo-conductor and an optical system with a line of sight inclined upwards at an angle of 45 degrees to 55 degrees to the horizontal and in a vertical plane making an angle of 15 degrees to 45 degrees with the track rails. The photo-cell 16 has a narrow rectangular sensitive area and is mounted behind optical stops 18, 19 and an infrared passing filter 20. The cell sensitive area is imaged in a lengthened form on the leading edge of passing axle boxes 15 by a concave mirror 22 and a plane stainless steel mirror 21. Mirror 21 may be adjustably mounted so that it can be set for operation on either side of the track.