baber/WOPTO huggingface dataset:
Patent CA-3030565-A1 (CA)
Inventor: CHUNG DUANE
IPC: C12N9/22
Filed: 2017-07-04
Abstract: By this invention, for the first time, a method for high-efficiency site-specific genetic engineering, utilizing either native or heterologous CRISPR-Cas9 systems, in the anaerobic bacterium Clostridium pasteurianum, is provided. Application of CRISPR-Cas9 systems has revolutionized genome editing across all domains of life. Here we report implementation of the heterologous Type II CRISPR-Cas9 system in Clostridium pasteurianum for markerless genome editing. Since 74% of species harbor CRISPR-Cas loci in Clostridium, we also explored the prospect of co-opting host-encoded CRISPR-Cas machinery for genome editing. Motivation for this work was bolstered from the observation that plasmids expressing heterologous cas9 result in poor transformation of Clostridium. To address this barrier and establish proof-of-concept, we focus on characterization and exploitation of the C. pasteurianum Type I-B CRISPR-Cas system. In silico spacer analysis and in vivo interference assays revealed three protospacer adjacent motif (PAM) sequences required for site-specific nucleolytic attack. Introduction of a synthetic CRISPR array and cpaAIR gene deletion template yielded an editing efficiency of 100%. In contrast, the heterologous Type II CRISPR-Cas9 system generated only 25% of the total yield of edited cells, suggesting that native machinery provides a superior foundation for genome editing by precluding expression of cas9 in trans. To broaden our approach, we also identified putative PAM sequences in three key species of Clostridium. This is the first report of genome editing through harnessing native CRISPR-Cas machinery in Clostridium.
Patent CA-3034582-A1 (CA)
Title: Reseaux d'images pour dispositifs optiques et leurs procedes de fabrication
Inventor: LISTER ADAM
IPC: B42D25/30
Filed: 2017-08-10
Abstract: L'invention concerne un procédé de fabrication d'un réseau d'images pour un dispositif optique, ledit procédé consistant en : (a) la génération d'une pluralité de différentes images de masque par, pour chaque image parmi au moins deux différentes images, lesdites images comprenant collectivement des parties présentant au moins deux couleurs différentes : (a1) la production d'une version pixelisée de l'image comprenant une pluralité de pixels d'image, chaque pixel d'image exposant une couleur uniforme; (a2) pour chacun des pixels d'image de l'image pixelisée, la création d'un pixel de masque correspondant basé sur la couleur du pixel d'image correspondant, chaque pixel de masque comprenant un agencement d'une ou plusieurs régions de masque et/ou une ou plusieurs régions vides, différents agencements desdites régions de masques et/ou régions vides dans les différents pixels de masques définissant différentes couleurs correspondantes ; (a3) la disposition de pixels de masque selon les positions de leurs pixels d'image correspondants dans l'image pixelisée pour former une image de masque; (b) l'entrelacement de la pluralité de différentes images de masque, en divisant chaque image de masque en tranches d'image allongée s'étendant le long d'une première direction, sélectionnant un sous-ensemble de tranches d'image à partir de chaque image de masque, et en agençant les tranches d'image sélectionnées à partir de l'ensemble des images de masque pour former une image de masque entrelacée dans laquelle les tranches d'image de chaque image de masque correspondante alternent les unes avec les autres de façon régulière le long d'une seconde direction qui est sensiblement perpendiculaire à la première direction; puis, dans n'importe quel ordre ou simultanément : (c) la formation d'une couche de masque comprenant un matériel de masquage dont le profil correspond à l'image de masque entrelacée; et (d) la formation d'une couche de couleur comprenant des bandes allongées d'au moins deux couleurs différentes en alternance l'une avec l'autre de façon régulière dans la première direction, les bandes allongées s'étendant le long de la seconde direction; la couche de masque et la couche de couleur s'agençant au moins pour se chevaucher l'une et l'autre, ce qui permet aux régions vides des pixels de masque dans la couche de masque de dévoiler des parties de la couche de couleur de manière que, combinées, la couche de masque et la couche de couleur forment des versions d'exposition d'un réseau d'image multicolore d'au moins deux images entrelacées l'une avec l'autre.
Patent CA-3037304-A1 (CA)
Inventor: RAJAGOPALAN ANAND G
IPC: A47F3/04
Filed: 2017-08-14
Abstract: L'invention concerne un présentoir réfrigéré comprenant un coffre comportant une base et un abri définissant au moins partiellement une zone de présentation de produits. Une ou plusieurs plaques eutectiques sont positionnées dans la zone de présentation de produits. Les plaques eutectiques comprennent un fluide contenu dans un boîtier. Un échangeur de chaleur comprenant une bobine est positionné dans le boîtier pour refroidir le fluide. La bobine comporte une entrée, une sortie espacée de l'entrée, une première partie et une seconde partie adjacente et en communication thermique avec la première partie pour définir un échangeur de chaleur tube à tube.
Patent CA-3037830-A1 (CA)
Title: Mobile service applications
Inventor: BURTON MICHAEL
IPC: G06F9/44
Filed: 2017-09-22
Abstract: Techniques for improved mobile application architectures and service communication protocols are discussed herein. Some embodiments may include a mobile device configured for providing a mobile application including multiple service applications. The service applications may execute asynchronously and in separate containers, providing service orientated architecture (SOA)-like services with respect to other portions of the mobile application, or even external applications. The separation of a monolithic mobile application into separate service applications provide advantages in terms of application performance, development, and maintenance. For example, a subset of all service applications may be started up, and executed on demand to improve device resource utilization efficiency.
Patent CA-3037875-A1 (CA)
Title: Utilisation d'hydrolases alpha-1,4/1,6-glycoside actives a ph faible en tant qu'additif alimentaire pour ruminants pour ameliorer la digestion de l'amidon
Inventor: YU SHUKUN
IPC: A23K20/189
Filed: 2017-09-15
Abstract: L'invention concerne des utilisations d'au moins une hydrolase alpha-1,4/1,6-glycoside (GLCH) en tant qu'additif alimentaire pour un ruminant, ladite hydrolase : (a) ayant au moins 20 % d'activité à un pH inférieur ou égal à 3 en présence de pepsine par rapport à l'activité de l'hydrolase à un pH de 6 en présence de pepsine, (b) ladite hydrolase étant active dans au moins deux de trois chambres digestives d'un ruminant comprenant le rumen, la caillette et l'intestin grêle et (c) l'hydrolase fonctionnant avec l'amylase pancréatique pour augmenter la production de glucose.
Patent CA-3043681-A1 (CA)
Inventor: GOLDBERG ZELANNA IRIS
IPC: A61K31/519
Filed: 2017-11-07
Abstract: L'invention concerne une méthode de traitement du cancer du poumon non à petites cellules par administration à un patient le nécessitant d'un inhibiteur de T790M de l'EGFR en combinaison avec un inhibiteur de CDK.
Patent CA-3044446-A1 (CA)
Title: Modular solid state high bay lighting fixture with hinged access panel
Inventor: CHAMI AYMEN
IPC: F21V15/01
Filed: 2019-05-28
Abstract: A modular solid state high bay lighting fixture is provided herein which includes at least two lighting modules, each including a body configured to define an open channel along one face thereof with a lens or diffuser at least partly overlying each of the open channels.  Bottom and upper plates extend between the lighting modules with the upper plate being spaced from, and at least partially overlying, the bottom plate so that a chamber is formed therebetween. The bottom plate is movable relative to the bodies of the lighting module from a first state, where the bottom plate is edge supported, to a second state, where one edge is clear of the bodies allowing the bottom plate to rotate.
Patent CA-3044731-A1 (CA)
Title: Method and system for managing a rechargeable electric or hybrid vehicle
Inventor: BARDOT CHRISTOPHE
IPC: B60L58/20
Filed: 2017-12-19
Abstract: The invention relates to a method (100) for managing an electric or hybrid vehicle comprising at least one rechargeable electric energy storage module, each storage module being arranged to: - provide a high-voltage electrical power supply signal for the traction of said vehicle, and - be maintained at a, so-called operating, temperature by a heating means; said method (100) comprising, before a prolonged period of non-use of said vehicle, a phase (104), of so-called wintering, comprising a step (108, 110) of cooling each storage module so as to reach a predetermined temperature below said operating temperature. It also relates to a system and a vehicle implementing such a method.
Patent CA-3045312-A1 (CA)
Title: Tooling base
Inventor: TAYLOR CHRIS
IPC: B23Q3/18
Filed: 2018-09-09
Abstract: A tooling base that is an improvement over current designs in the form of simplified number of parts, easier manufacturing of parts and that can be actuated for clamping and releasing a tooling fixture by pneumatic, other computer controlled means as well as manually is described. The tooling base uses clamping fixtures that are spring loaded to press cleats into recesses on alignment studs that locate and hold any variety of tooling fixtures to the base.
Patent CA-3046384-A1 (CA)
Title: Techniques to identify sets of multiple beams compatible with configurations for routing signals in a user equipment
Inventor: CEZANNE JUERGEN
IPC: H04B7/0404
Filed: 2017-12-27
Abstract: Techniques are described for wireless communication. A method for wireless communication at a user equipment (UE) may include receiving a beam training sequence transmitted by a network access device on a plurality of transmit beams, identifying, based at least in part on the received beam training sequence, one or more sets of multiple beams that are compatible with at least one configuration for routing signals between antenna subarrays of the UE and transceiver units (TXRUs) of the UE, and transmitting, to the network access device, an indication of the identified one or more sets of multiple beams. A method for wireless communication at the network device may include transmitting the beam training sequence, receiving the indication, and selecting, based at least in part on the received indication, a set of multiple beams of the one or more sets of multiple beams to use to communicate with the UEs.
Patent CA-3047705-A1 (CA)
Inventor: KAPLAN NOAM
IPC: A23G3/38
Filed: 2017-11-23
Abstract: The present invention, in some embodiments thereof, relates to low calorie, and nutritious sweeteners and confectioneries. The sweeteners and confectioneries of the invention are enriched with at least one type of soluble fibers and with proteins and include limited amounts of sweetening agents. The present invention further relates to methods of manufacturing the herein disclosed sweeteners and confectioneries.
Patent CA-3050197-A1 (CA)
Title: A process and system to capture ammonia from a purge gas of a urea plant
Inventor: RUGNONE LUCA
IPC: C07C273/16
Filed: 2018-02-01
Abstract: A process and system for removing ammonia from ammonia-containing purge gas of a urea plant, the process comprising: contacting said ammonia- containing purge gas with carbon dioxide at a low temperature, reaction of ammonia to form crystals of ammonium salts in a multiphase stream,and removal of the solid ammonium salts from the multiphase stream.
Patent CA-3051335-A1 (CA)
Title: Ventilating appliance
Inventor: EBINGER ANDREA
IPC: A61M16/08
Filed: 2019-08-07
Abstract: For a ventilating appliance (1) consisting of a ventilating device (2) having an air outlet channel (3) and an air inlet channel (4), two hoses (5, 6) which are connected to one of the two channels (3, 4) of the ventilating device (2), an air distributor (7), on which three openings (8, 9, 10) are provided, which are coupled to one of the two hoses (5, 6) of the ventilating device (2) and to a tube (11) which can be inserted into the mouth or nose space (22) of a living being (21), shall the ventilating appliance (1) be improved that a patient to be ventilated undergoes a release of mucus and its removed from the lung area with cost-effective measures, without the need for foreign objects or switching off the ventilating appliance (1). This is solved in that a respiratory tract therapy device (31) is inserted in the inhalation hose (5), in that an air flow (12) is generated by the ventilating device (2), through which an intermittent air pressure fluctuation arises with the respiratory tract therapy device (31), and in that the air pressure fluctuations generated in this way are passed on or transmitted in the lung region (23) of the living being (21).
Patent CA-3051904-A1 (CA)
Title: Damping device for a bearing housing
Inventor: TOMES NATHAN
IPC: F16F13/10
Filed: 2019-08-12
Abstract: A damping device for connecting a bearing housing to a bearing outer race is provided.  The damping device may permit an allowable range of radial movement of the bearing.  The damping device has an elastomeric body connected to one of the bearing outer race and the bearing housing and a cover portion connected to the other one of the bearing outer race and the bearing housing. It also has two or more deformable fluid chambers fluidly connected to one another via at least one orifice and in which fluid is encapsulated. The damping device may dissipate at least partially vibrations travelling between the bearing housing and the bearing outer race by compressing its elastomeric body and by discharging fluid from one fluid chamber to another. There may be a plurality of such damping devices disposed circumferentially about the bearing outer race.
Patent CA-3052155-A1 (CA)
Title: Methods and systems for welding copper using blue laser
Inventor: FINUF MATTHEW
IPC: B23K26/00
Filed: 2018-01-31
Abstract: A visible light laser system and operation for welding materials together. A blue laser system that forms essentially perfect welds for copper based materials. A blue laser system and operation for welding conductive elements, and in particular thin conductive elements, together for use in energy storage devices, such as battery packs.
Patent CA-3053050-A1 (CA)
Inventor: HAYATBAKSH ARMIN A H
IPC: C02F1/42
Filed: 2019-09-09
Abstract: The invention proposes an efficient process for the treatment of high alkalinity and high hardness wastewaters (ion exchange regeneration wastewater, IERW) using a hybrid chemical/membrane treatment process. The method uses both waste streams as a novel self-coagulant for the chemical treatment. The high hardness wastewaters are capable of removing a significant portion of contaminants from high alkaline wastewaters. The proposed method can operate with a zero liquid discharge (ZLD) configuration and a low operating cost since requires zero/minimized expense for chemical coagulant. Two-hybrid technologies were developed; the first method involved treating the high alkaline wastewater with a hybrid of self-coagulant conditioning and membrane separation treatment. In the second process, the high alkaline waste stream was purified with membrane separation and then the concentrated retentate was treated by self-coagulant conditioning and a second membrane unit.
Patent CA-3054015-A1 (CA)
Inventor: BLACK JOSEPH
IPC: F01D25/18
Filed: 2019-09-04
Abstract: A system includes an air chamber and an oil capture cavity. The air chamber includes an inlet to receive pressurized air from a gas turbine engine. The oil capture cavity is positioned between the air chamber and an oil sump supplying lubricating oil to the gas turbine engine. The oil capture cavity includes an auxiliary vent formed in a base of the oil capture cavity. A seal may separate the oil capture cavity from fluid communication with the oil sump. A nozzle provides fluid communication between the oil capture cavity and the air chamber. The nozzle is configured and positioned to direct a stream of the pressurized air into the oil capture cavity against an opposite wall of the oil capture cavity to create a quiescent zone at the base of the oil capture cavity. The quiescent zone includes the auxiliary vent.
Patent CA-3054035-A1 (CA)
Inventor: ALLEN PHILLIP DAVID
IPC: G06F21/62
Filed: 2018-03-14
Abstract: Systems, methods, and software for data privacy annotation frameworks for user applications are provided herein. An exemplary method includes identifying at least a first threshold quantity, an elasticity factor for modifying the first threshold quantity to a second threshold quantity, and an indication of a threshold resiliency property indicating when the second threshold quantity overrides the first threshold quantity. The method includes monitoring a content edit process of user content to identify a quantity of the user content that contains sensitive data corresponding to one or more predetermined data schemes, and during the content edit process, enabling and disabling presentation of annotation indicators for the content elements based at least in part on a current quantity with regard to the first threshold quantity, the elasticity factor for the first threshold quantity when enabled, and the indication of the threshold resiliency property.
Patent CA-3054597-A1 (CA)
Title: Module de transfert de tri de colis et systemes et procedes associes
Inventor: LUNDAHL ROBERT D
IPC: B65G17/24
Filed: 2018-03-08
Abstract: L'invention concerne un ensemble module de transfert comportant un cadre, une courroie transporteuse dotée d'éléments rotatifs internes, la courroie transporteuse étant soutenue par le cadre, des rouleaux d'entraînement de transporteur soutenus par le cadre et conçus pour entraîner la courroie transporteuse, une courroie de transfert plate montée sous la courroie transporteuse et conçue pour entrer en contact avec les côtés inférieurs des éléments rotatifs internes de la courroie transporteuse en fonctionnement, et des rouleaux d'entraînement de courroie de transfert plate soutenus par le cadre et conçus pour entraîner la courroie de transfert plate. Les rouleaux d'entraînement de transporteur sont basés sur le frottement et fonctionnent sans utilisation d'un pignon, et comprennent des creux destinés à recevoir les éléments rotatifs internes de la courroie transporteuse.
Patent CA-3056192-A1 (CA)
Title: Element d'absorption de chocs et element lateral d'automobile
Inventor: MIKAZUKI YUTAKA
IPC: B62D25/20
Filed: 2017-03-31
Abstract: La présente invention concerne un élément d'absorption de chocs s'étendant dans la direction longitudinale d'un véhicule, les deux extrémités dans le sens de la longueur comprenant une extrémité côté collision et une extrémité côté non-collision qui occupent des positions différentes lorsqu'elles sont observées dans le sens de la longueur le long du véhicule, un élément externe et un élément interne de l'élément d'absorption de chocs étant formés de telle sorte que les centres de gravité pour l'extrémité côté collision et l'extrémité côté non-collision varient l'un de l'autre en conservant les positions relatives de l'extrémité côté collision et de l'extrémité côté non-collision afin de réduire la contrainte de traction générée au niveau de l'extrémité côté collision et la contrainte de compression générée au niveau de l'extrémité côté non-collision pendant une collision.
Patent CA-3061062-A1 (CA)
Inventor: DAVIDSON KYLE ROBERT
IPC: F16L11/127
Filed: 2019-11-07
Abstract: Il est décrit un tuyau pulvérisateur pour un dispositif de distribution de fluide comprenant un tuyau deau ayant une surface extérieure. De plus, le tuyau pulvérisateur comprend au moins un fil électrique enroulé de manière hélicoïdale autour de la surface extérieure du tuyau deau, ainsi quune couche de revêtement, disposé à lextérieur par rapport au tuyau deau et des fils électriques.
Patent CA-3061752-A1 (CA)
Title: Agents arni d'inhibition d'expression de gene alpha-enac et methodes d'utilisation
Inventor: LI ZHEN
IPC: C12N15/113
Filed: 2018-07-05
Abstract: L'invention concerne des agents ARNi, des compositions qui comprennent des agents ARNi, et des méthodes d'inhibition d'un gène alpha-ENaC (SCNN1A). Les agents ARNi d'alpha-ENaC et les conjugués d'agents ARNi décrits dans la description inhibent l'expression d'un gène alpha-ENaC. L'invention concerne également des compositions pharmaceutiques comprenant un ou plusieurs agents ARNi d'alpha-ENaC, éventuellement avec un ou plusieurs agents thérapeutiques supplémentaires. L'administration in vivo des agents ARNi d'alpha-ENaC de l'invention à des cellules épithéliales, telles que des cellules épithéliales pulmonaires, permet une inhibition de l'expression du gène alpha-ENaC et une réduction de l'activité ENaC, ce qui peut être thérapeutiquement bénéfique pour des sujets, notamment pour des sujets humains.
Patent CA-3062227-A1 (CA)
Title: Procede de construction de propulseurs ou de moteurs contenus dans un carter cylindrique et propulseur ou moteur associe
Inventor: CARROUSET PIERRE
IPC: F01D5/04
Filed: 2018-05-03
Abstract: These new thrusters simultaneously use wheels of the CARPYZ THRA "Turbo Powered Helicopter Reactor" type and wheels of the CARPYZ TaG ''Bucket Turbines'' type or wheels of the CARPYZ TaC ''Scoop Turbines" type, representing real global technological breakthroughs for fluid mechanics. They use, upon vertical take-off of the aircraft, propellers driven by electric motors and temporarily use the required additional high vertical axial thrust that is then supplied by the reactors of the THRA wheels, which also use an energetic fluid. The CARPYZ type thrusters, due to the low diameter and weight afforded thereto, are progressively horizontally inclined and the force of the reactors is progressively replaced by that of the propellers, which then supply the flows required in order for the aircraft to travel horizontally using wings that rely on the lift of the fluid, like airplanes. Photovoltaic wings are then deployed that are like butterfly wings and this economical solution will enable voyages over longer distances. It really is the safe mass market vertical take-off car of the future that can be achieved in less than 10 years by virtue of the new CARPYZ type thrusters, the little things change everything!
Patent CA-3063098-A1 (CA)
Title: Folding enclosure
Inventor: MCGREGOR SHAWN
IPC: B60P3/355
Filed: 2018-05-08
Abstract: An aspect includes a transportable fold-out at least partial enclosure (10, 10', 200, 500) including: a center stationary section (12, 212, 512); a pair of primary platform assemblies (30A,30B; 230A,230B; 530A,530B), each primary platform (30A,30B; 230A,230B; 530A,530B) including a first panel (34; 234; 534) pivotally joined on opposite sides of the center stationary section (12, 212, 512) and a second panel (36; 295,297; 595,597)pivotally joined to the first panel (34; 234; 534) on a side opposite the first panel (34; 234; 534); and at least one wall assembly (70,72,70', 72', 270,272, 570,572) pivotally joined to center stationary section (12, 212, 512) and one of the primary platforms (30A,30B; 230A,230B; 530A,530B).
Patent CA-3063720-A1 (CA)
Title: Grip accessory for a manual injection device
Inventor: MCLUSKY JAMES
IPC: A61M5/315
Filed: 2018-05-29
Abstract: A grip accessory (300) for a manual injection device comprises a housing (310) comprising a generally hollow body configured to support a manual injection device (100) therein. The housing comprises a distal portion (330) comprising a first opening into which a manual injection device can be inserted, a proximal portion (320) having a second opening through which the needle of the manual injection device extends. The proximal portion comprises a skin contacting surface at a proximal end of the device that can be placed against an injection site. An intermediate portion (340) extends between the proximal and distal portions.