baber/WOPTO huggingface dataset:
Patent CA-3112865-A1 (CA)
Title: Procede de coulee-laminage destine a la fabrication d'une structure en spirale
Inventor: WOSTMANN FRANZ-JOSEF
IPC: H01F41/04
Filed: 2019-09-19
Abstract: La présente invention concerne un procédé de coulée-laminage destiné à la fabrication d'une structure en spirale, notamment d'une structure en spirale aux fins d'utilisation dans les machines électriques, une masse en fusion étant alimentée entre un premier cylindre et un deuxième cylindre rotatif diamétralement opposé à ce dernier, le premier cylindre ayant des premières dents et le deuxième cylindre ayant des deuxièmes dents, lesdites premières et/ou deuxièmes dents étant dotées de flancs pourvus de cavités pour recevoir la masse en fusion alimentée, les dents étant conçues et orientées de manière telle que lors de la rotation des cylindres, la cavité au moins d'une dent soit, au moins par intermittence, délimitée par une surface d'une dent de l'autre cylindre de manière à ce que la masse en fusion alimentée entre les dents soit moulée par refroidissement et moulée pour obtenir une section de la structure en spirale.
Patent CA-3113325-A1 (CA)
Title: A method to treat disease using a nucleic acid vector encoding a highly compact multi-input logic gate
Inventor: BENENSON YAAKOV
IPC: C12N15/11
Filed: 2019-10-10
Abstract: Disclosed herein are contiguous DNA sequences encoding highly compact multi-input genetic logic gates for precise in vivo cell targeting, and methods of treating disease using a combination of in vivo delivery and such contiguous DNA sequences.
Patent CA-3113515-A1 (CA)
Inventor: BONNEVILLE MYRIAM
IPC: G09B23/32
Filed: 2021-03-29
Abstract: A lung simulator including a lung bladder, a biasing system providing a relaxed expiration force to the lung bladder with a positive end-expiratory pressure and simulating lung compliance, and a frame holding the lung bladder and biasing member in position. The lung bladder may be inflated and deflated between a positive end-expiratory pressure and a peak inspiratory pressure through the means of a ventilator, a bag mask or mouth to mouth ventilation and may produce a pressure-volume curve similar to that of a lung when the lung bladder is connected to a ventilation source.
Patent CA-3113758-A1 (CA)
Title: Adaptive service unit of a beverage machine
Inventor: ABDO SAMER
IPC: A47J31/44
Filed: 2019-09-27
Abstract: A machine (1) for preparing a beverage has: a body (1') comprising a seat (4) and a beverage processing line (1'', 1''') extending from a liquid inlet (1'') to a beverage dispenser (1'''); and a service unit (10) that is removably received in or on the seat (4) and that comprises a foot part (11) and a recipient part (12) removably received in or on the foot part (11) so as to be supported thereby. The foot part (11) has a bottom face (11') configured to rest on an external horizontal support surface (100) when the service unit (10) is removed from the seat (4). When the recipient part (12) is received in or on the foot part (11), the recipient part (12) is movable relative to the foot part (11) from a first stable position when the service unit (10) rests on the external horizontal support surface (100) to a second stable position when the service unit (10) is received in or on the seat (4), and vice versa.
Patent CA-3114208-A1 (CA)
Title: Inhibitors of vap-1
Inventor: ORME MARK W
IPC: C07D249/18
Filed: 2019-09-27
Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
Patent CA-3115545-A1 (CA)
Title: Bispecific antibodies for activation of immune cells
Inventor: TSURUSHITA NAOYA
IPC: A61P35/00
Filed: 2019-11-12
Abstract: The invention provides bispecific antibodies having one arm binding to a cancer associated antigen on a cancer cell, such as CD33, EGFR or PD-L1, and a second arm binding to a costimulatory molecule, such as 0X40, CD40, GITR, ICOS or 4-1BB. Bridging by the bispecific antibody between cancer cells expressing the cancer associated antigen and immune cells expressing the costimulatory molecule results in clustering of the costimulatory molecules and selective activation of the immune cells at a location proximate to the cancer cells. Thus, the immune cells can exert an immunotherapeutic effect against the cancer cells with reduced toxicity to healthy tissue.
Patent CA-3116197-A1 (CA)
Title: Portable dielectric spectroscopy device
Inventor: ERTEL JASON R
IPC: G01N33/24
Filed: 2019-11-14
Abstract: A portable DS device includes a device housing, device - side electrical contacts, a computing system and a removable sensor receiver assembly. The device housing includes a removable sensor receiver compartment. The device - side electrical contacts are positioned in or adjacent to the removable sensor receiver compartment. The computing system is in communication with the device - side electrical contacts and includes an impedance analyzer. The removable sensor receiver assembly includes a removable sensor receiver housing selectively receivable in and removable from the removable sensor receiver compartment. The removable sensor receiver housing includes a fluid sensing apparatus receiving section that receives a fluid sensing apparatus in which a fluid to be tested is loaded. The removable sensor receiver assembly provides for an electrical connection between the associated fluid sensing apparatus and the device - side electrical contact when the removable sensor receiver housing is received in the removable sensor receiver compartment.
Patent CA-3120135-A1 (CA)
Title: Cassette for a flow control apparatus
Inventor: BIERMANN WAYNE
IPC: A61M5/142
Filed: 2019-11-26
Abstract: A cassette for use with a pumping apparatus having a pumping system for engaging a pump set includes a cassette body configured for releasable attachment to the pumping apparatus to mount the cassette on the pumping apparatus. The cassette body has at least one mounting formation. At least one identification member is mounted on the cassette body by the mounting formation of the cassette body. The identification member and mounting formation are formed to mount the identification member in any one of a plurality of predetermined orientations. Each predetermined orientation indicates a different functional configuration of the pump set.
Patent CA-3120435-A1 (CA)
Title: Pause valve and swivel assemblies for oral irrigator handle
Inventor: WAGNER ROBERT
IPC: A61M39/10
Filed: 2017-12-15
Abstract: An oral irrigator handle through which fluid flows to a tip is described.  Fluid flows from a fluidically connected hose to the tip during irrigate mode, and fluid flow may be interrupted by selecting a pause mode. The handle includes a mechanically controlled actuator for selecting the pause mode. The actuator may be operably connected to a shuttle valve that is positioned to block fluid flow to the tip during pause mode but not during irrigate mode.  The handle may also include a swivel assembly. The swivel assembly prevents rotational movement of either the handle or the hose from being transmitted to the other, such that rotation of the handle will not affect the position of the hose.
Patent CA-3126500-A1 (CA)
Title: Method of prognosis of bronchopulmonary dysplasia in premature infants
Inventor: DE LUCA DANIELE
IPC: G16H50/30
Filed: 2021-07-30
Abstract: The present invention relates to a method for prognosis the risk of bronchopulmonary dysplasia in premature infant by adjusting a score obtained from lung ultrasound with the gestational age of the infant.
Patent CA-3129238-A1 (CA)
Title: Beverage dispensing systems with limited time offering circuits
Inventor: TRAN SON VAN
IPC: B67D1/08
Filed: 2020-02-04
Abstract: The present application provides a beverage dispenser capable of dispensing one or more limited time offering beverages. The beverage dispenser may include a dispensing valve, a limited time offering ingredient source, and a limited time offering circuit extending between the dispensing valve and the limited time offering ingredient source. The limited time offering circuit may include a stainless steel line extending between the dispensing valve and the limited time offering ingredient source.
Patent CA-3130366-A1 (CA)
Title: Systems and methods for managing voltage event alarms in an electrical system
Inventor: BICKEL JON A
IPC: H02J13/00
Filed: 2021-09-09
Abstract: Systems and methods for managing voltage event alarms in an electrical system are provided.  In one aspect of this disclosure, a method for managing voltage event alarms in an electrical system includes processing electrical measurement data from, or derived from, energy-related signals captured by at least one intelligent electronic device (IED) to identify an anomalous voltage condition at a point of installation in the electrical system. The anomalous voltage condition may correspond, for example, to a measured IED voltage being above or greater than one or more upper alarm thresholds or below or less than one or more lower alarm thresholds.  The method also includes determining if the electrical system is affected by the identified anomalous voltage condition. In response to determining that the electrical system is affected by the identified anomalous voltage condition, at least one of a plurality of criteria may be chosen to adjust at least one of the upper alarm thresholds and/or at least one of the lower alarm thresholds.
Patent CA-3130931-A1 (CA)
Inventor: KLUSSMANN BERTRAND R
IPC: C09K3/32
Filed: 2018-02-12
Abstract: A process for reducing the environmental contaminants in a ISO 8217 compliant Feedstock Heavy Marine Fuel Oil, the process involving: mixing a quantity of the Feedstock Heavy Marine Fuel Oil with a quantity of Activating Gas mixture to give a feedstock mixture; contacting the feedstock mixture with one or more catalysts to form a Process Mixture from the feedstock mixture; separating the Product Heavy Marine Fuel Oil liquid components of the Process Mixture from the gaseous components and by-product hydrocarbon components of the Process Mixture and, discharging the Product Heavy Marine Fuel Oil. The Product Heavy Marine Fuel Oil is compliant with ISO 8217 for residual marine fuel oils and has a sulfur level has a maximum sulfur content (ISO 14596 or ISO 8754) between the range of 0.05 % wt. to 0.5 % wt. . The Product Heavy Marine Fuel Oil can be used as or as a blending stock for an ISO 8217 compliant, IMO MARPOL Annex VI (revised) compliant low sulfur or ultralow sulfur heavy marine fuel oil. A device for conducting the process is also disclosed.
Patent CA-3131588-A1 (CA)
Inventor: DING BEIBEI
IPC: C07K14/725
Filed: 2020-02-27
Abstract: There is disclosed an improved, safer and commercially efficient process for developing genetically engineered cells. More specifically, there is disclosed a process comprises introducing a donor DNA construct, a guide RNA, and an RNA-guided nuclease with the host cells to he transfected; and introducing the three components into the host cell. There is further disclosed a donor DNA construct designed for inserting a CAR (chimeric antigen receptor) into a defined genomic site of a host cell. Further, the present disclosure provides a host cell transfected with a CAR that lacks viral vectors that can present a safety concern. The disclosure provides for more efficient and more cost-effective process for engineering T cells to express CAR constructs.
Patent CA-3133139-A1 (CA)
Inventor: BEERSTECHER JAN
IPC: A61C13/15
Filed: 2020-03-10
Abstract: A modular cord-less pen-style dental instrument comprising: (a) an elongated body for gripping and holding the instrument, which has a connector portion at the distal end thereof; (b) a wand portion having a proximal end adapted to be releasably connected to the connector portion at the distal end of the elongated body; wherein the dental instrument further comprises a heat flow barrier between the elongated body and the wand portion.
Patent CA-3133311-A1 (CA)
Title: Vesicules extracellulaires pour l'administration de vaccins
Inventor: MONIZ RAYMOND J
IPC: A61K39/00
Filed: 2020-03-20
Abstract: La présente invention concerne des vésicules extracellulaires (VE), par exemple, des exosomes, comprenant une charge utile (par exemple, un antigène, un adjuvant et/ou un modulateur immunitaire) et/ou une fraction de ciblage. L'invention concerne également des procédés de production de VE (par exemple, des exosomes) et des procédés d'utilisation des VE (par exemple, des exosomes) pour traiter et/ou prévenir des maladies ou des troubles, par exemple le cancer, une maladie du greffon contre l'hôte (GVH), une maladie auto-immune, des maladies infectieuses ou des maladies fibrotiques.
Patent CA-3135065-A1 (CA)
Title: Element chauffant ceramique avec capteur de temperature integre pour un vaporisateur electronique
Inventor: ROSEN JAMIE MICHAEL
IPC: A24F40/46
Filed: 2021-10-20
Abstract: Un vaporisateur électronique comprend une unité principale, un vaporisateur et une embouchure. Le vaporisateur est raccordé de manière amovible à lunité principale. Lembouchure est raccordée de manière amovible au pulvérisateur. Le pulvérisateur comprend une base de pulvérisateur, une électrode de chauffage couplée à la base de pulvérisateur, une électrode de captage de la température couplée à la base de pulvérisateur, un élément chauffant couplé électriquement à lélectrode de chauffage et lélectrode de captage de température et un creuset de chauffage couplé thermiquement à lélément chauffant. Lélément chauffant comprend une base délément chauffant, un circuit de chauffage encapsulé dans la base délément chauffant et un circuit de détection de température encapsulé dans la base délément chauffant.
Patent CA-3136230-A1 (CA)
Title: Combinaison pharmaceutique de pimozide et de methotrexate et utilisation correspondante
Inventor: FU XIN-YUAN
IPC: A61P19/02
Filed: 2020-04-03
Abstract: L'invention concerne une combinaison pharmaceutique de pimozide et de méthotrexate et une utilisation correspondante. La combinaison pharmaceutique comprend du méthotrexate, un sel pharmaceutiquement acceptable correspondant, un solvate correspondant ou un solvate du sel pharmaceutiquement acceptable correspondant ; et du pimozide, un sel pharmaceutiquement acceptable correspondant, un solvate correspondant, ou un solvate du sel pharmaceutiquement acceptable correspondant. La combinaison pharmaceutique peut être utilisée pour le traitement de la polyarthrite rhumatoïde.
Patent CA-3136240-A1 (CA)
Inventor: FRALIN JOEY
IPC: F24F13/28
Filed: 2020-04-09
Abstract: Un ensemble filtre à air pliable pour un système de conditionnement d'air de chauffage et de ventilation (HVAC) comprend un élément filtrant, et un cadre supportant l'élément filtrant. Le cadre comprend au moins deux bords comprenant chacun un élément de ressort respectif configuré pour être mobile entre un état ouvert et un état plié. Un ensemble filtre à air compressible pour un système (HVAC) comprend un milieu filtrant ayant des plis arrondis configurés pour s'affaisser et rebondir de manière contrôlée et répétable entre un état comprimé et un état non comprimé d'origine. Un ensemble filtre à enveloppe souple comprend un cadre dans une configuration de boîte. Le cadre comprend des bords et des ouvertures rigides pour permettre un écoulement d'air. Un élément filtrant est renfermé dans le cadre. Des couvercles de bord flexibles montés sur des bords respectifs du cadre fournissent un joint étanche à l'air dans un système HVAC.
Patent CA-3137393-A1 (CA)
Inventor: WANG JIANMIN
IPC: A61K9/00
Filed: 2019-04-30
Abstract: L'invention concerne des procédés de traitement de patients atteints de ou présentant des symptômes de troubles mentaux, comportementaux et/ou cognitifs avec de l'azélastine ou un sel pharmaceutiquement acceptable d'azélastine.
Patent CA-3139785-A1 (CA)
Title: Processing unit and processing machine for processing a workpiece on a workpiece wall and method for producing a processing unit of the stated type
Inventor: TRAUTZ UDO
IPC: B21J5/12
Filed: 2020-04-28
Abstract: A processing unit (1) for processing a workpiece (7) on a workpiece wall has a processing tool (3), a tool abutment (4) and also a clamping device (5). In the processing of the workpiece, the processing unit (1) performs along a working axis (8) a forward stroke in a forward-stroke direction (9) and a return stroke in a return-stroke direction (10) with respect to a workpiece (7) to be processed. The processing tool (3) is supported In the forward stroke on an abutment-side forward-stroke supporting surface (11) of the tool abutment (4) and in the return stroke on an abutment-side return-stroke supporting surface (13) of the tool abutment (4) along the working axis (8). The abutment-side return-stroke supporting surface (13) is kept at a distance from the abutment-side forward-stroke supporting surface (11) in the return-stroke direction (10) and is facing away from the abutment-side forward-stroke supporting surface (11). The clamping device (5) comprises a tensioning element (14), which is structurally separate from the tool abutment (4) and, along the working axis (8), on one side is connected to the processing tool (3) and on the other side has an adjusting thread (19), with which an adjusting element (15) of the clamping device (5) is in threaded engagement. The tensioning element (14) of the clamping device (5) can be pretensioned along the working axis. With the tensioning element (14) pretensioned, the processing tool (3) is clamped against the abutment-side forward-stroke supporting surface (11) and against the abutment-side return-stroke supporting surface (13) by means of the tensioning element (14) and by means of the adjusting element (15) acting on the abutment-side return-stroke supporting surface (13) along the working axis (8) in the direction of the processing tool (3). A processing machine has a processing unit (1) of the aforementioned type. A processing unit (1) of the aforementioned type is produced by the tensioning element (14) of the processing unit (1) being pretensioned by means of a tensioning apparatus.
Patent CA-3140525-A1 (CA)
Inventor: AL-NAKHLI AYMAN R
IPC: C09K8/66
Filed: 2020-04-29
Abstract: L'invention concerne un procédé de stimulation de la production d'hydrocarbures à partir d'une formation de grès comprend les étapes consistant à injecter un fluide de stimulation formé à partir d'un précurseur générant de l'acide fluorhydrique et d'un agent oxydant, un composé contenant de l'ammonium, et un composé contenant du nitrite dans la formation de grès, l'un ou les deux parmi le précurseur générant de l'acide fluorhydrique et l'agent oxydant comprenant une encapsulation dégradable. Le procédé comprend en outre le maintien du fluide de stimulation, du composé contenant de l'ammonium et du composé contenant du nitrite dans la formation de grès pour initier la réaction et générer de la chaleur et de l'azote gazeux. Lors de la génération de chaleur et de la dégradation de l'encapsulation dégradable, le précurseur générant de l'acide fluorhydrique et l'agent oxydant réagissent pour former de l'acide fluorhydrique in situ afin de dissoudre la silice et les minéraux de silicate et stimuler la formation de grès. Un fluide de traitement destiné à être utilisé dans la stimulation de formations de grès comprend le fluide de stimulation, le composé contenant de l'ammonium et le composé contenant du nitrite.
Patent CA-3142936-A1 (CA)
Inventor: HERRERA DEREK
IPC: A61M25/00
Filed: 2020-06-09
Abstract: L'invention concerne un cathéter urinaire (10) qui peut être retenu à l'intérieur du corps pendant des périodes prolongées. Un dispositif d'accouplement de cathéter peut être relié au cathéter pour déplacer le cathéter à l'intérieur du corps ou le retirer du corps. Le cathéter comprend un ou plusieurs éléments parmi : (1) une partie de retenue (20) ayant un couvercle externe (22), une cavité interne (23), et au moins une structure à l'intérieur de la cavité interne qui exerce une force vers l'extérieur sur le couvercle externe, et (2) un rabat extensible (19) au niveau de l'extrémité distale du cathéter. La partie de retenue et/ou le rabat extensible sont chacun configurés pour retenir le cathéter dans la position appropriée à l'intérieur du corps d'un utilisateur.
Patent CA-3143367-A1 (CA)
Title: Indazole derivative, preparation method therefor, and pharmaceutical application thereof
Inventor: FAN XING
IPC: C07D401/06
Filed: 2020-06-18
Abstract: An indazole derivative, a preparation method therefor, and a pharmaceutical application thereof. In particular, the present invention relates to an indazole derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use of the derivative as an estrogen receptor modulator in the prevention and/or treatment of an estrogen receptor mediated or dependent disease or condition, the disease being particularly preferably breast cancer. The definition of each substituent in the general formula (I) is the same as that in the description.
Patent CA-3145096-A1 (CA)
Inventor: TIBSS GARETH R
IPC: C07D207/46
Filed: 2019-06-27
Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
Patent CA-3147987-A1 (CA)
Title: Push-pump for dispensing soap or other liquids
Inventor: YANG FRANK
IPC: B67D7/60
Filed: 2022-02-04
Abstract: Disclosed herein are embodiments of a manually operated liquid dispenser. In any embodiments disclosed herein, the dispenser can include a housing with a volume of space therein, the volume of space having a first end and a second end, a pump sleeve extending into the space of the housing and nearly to a bottom, inside surface of the space, a pump head, a push rod coupled with the pump head and configured to be axially movable within an axial opening extending through the pump sleeve, a passageway extending through at least the pump head and the push rod, the passageway being in fluid communication with the axial opening extending through the pump sleeve and with the volume of space within the housing, and a first valve configured to control a passage of a liquid substance within the volume of space in the housing through a passageway.
Patent CA-3148578-A1 (CA)
Inventor: HAJI SOLEIMANI BEHROUZ
IPC: G06Q10/04
Filed: 2021-07-27
Abstract: Systems and methods for reconciling a forecast within a hierarchy, comprising a pre-processing module and a forecast reconciliation module. The pre-processing module reconstructs the structure of the hierarchy and captures the relationship between the nodes of the hierarchy in a summation matrix S. The forecast reconciliation matrix uses S, a weight matrix W (that reflects a weighting scheme between the nodes) and a base forecast to optimize the overall forecast error using a least squares procedure. The reconciled forecast has a zero consistency error.
Patent CA-3152786-A1 (CA)
Title: Procedes et compositions pour la modulation du vieillissement cellulaire
Inventor: NICOLIS DI ROBILANT BENEDETTA
IPC: C12N5/0789
Filed: 2020-08-31
Abstract: L'invention concerne des procédés et des compositions pour moduler le vieillissement cellulaire comprenant la mise en contact d'une cellule avec un inhibiteur de USP16. Les procédés de l'invention peuvent être utilisés pour améliorer l'efficacité de thérapies cellulaires, comprenant des thérapies à cellule réceptrice antigénique chimérique (CAR)-T, des thérapies à cellules réceptrice de lymphocytes T modifiés (TCR), des thérapies à cellules tueuses naturelles (NK), des thérapies à base de cellules souches hématopoïétiques et d'autres thérapies cellulaires adoptives.