Patent SG-11201810726Q-A (SG)
Title: Composition comprising self-assembling peptides for use in treatment of gingivitis, periodontitis and/or peri-implantitis
Inventor: HUG MICHAEL
IPC: A61Q11/00
Filed: 2017-08-16
Abstract: FigB W O 20 18/03357 0 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIP0 I PCT IiiimmomiolollmonoloolllnomioomoilomovoimIE (10) International Publication Number WO 2018/033570 Al (51) International Patent Classification: A61K 38/08 (2006.01) A61K 9/00 (2006.01) A61P 31/04 (2006.01) A61L 31/14 (2006.01) A61P 29/00 (2006.01) A61Q 11/00 (2006.01) A61P 1/02 (2006.01) (21) International Application Number: PCT/EP2017/070758 (22) International Filing Date: 16 August 2017 (16.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16184309.9 16 August 2016 (16.08.2016) EP 16200655.5 25 November 2016 (25.11.2016) EP (71) Applicant: CREDENTIS AG [CH/CH]; Dorfstrasse 69, 5210 Windisch (CH). (72) Inventors: HUG, Michael; Rigiweg 11, 4800 Zofmgen (CH). LYSEK, Dominikus Amadeus; Mfilligerstrasse 16t, 5210 Windisch (CH). KOCH, Franziska; Im Kirchack- er 18, 79400 Kandern-Tannenkirch (DE). JUNG, Ronald; Schiedhaldensteig 38, 8700 Kfisnacht (DE). MATHES, Stephanie; Wolfzangenstrasse 82, 8413 Neftenbach (CH). MEYER, Nina; Nordstrasse 118, 8037 Zfirich (CH). HAMMERLE, Christoph; Bodenacherstrasse 92, 8121 Benglen (CH). BROSELER, Frank; Lohmffilstrasse lc, 52074 Aachen (DE). PIELES, Uwe; Rene-Schickelestrasse 1, 79379 Milhlheim/Baden (DE). (74) Agent: MORE, Solveig; Kroher Strobel Rechts- und Paten- tanwalte PartmbB, Bavariaring 20, 80336 Mfinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (54) Title: COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS (57) : The present invention provides a composition comprising spe- cific self-assembling peptides, which are capable of self-assembly at a pH be- low 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition. [Continued on next page] WO 2018/033570 Al MIDEDIMOMMIDIREIHNIMIHOMINEMOVOIS MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))