baber/WOPTO huggingface dataset:
Patent WO-2020167886-A1 (WO)
Title: Methods of managing vascular conditions and diabetic peripheral neuropathies
Inventor: YOON YOUNG-SUP
IPC: A61K31/166
Filed: 2020-02-12
Abstract: This disclosure relates to managing diabetic neuropathy using compounds disclosed herein. In certain embodiments, this disclosure relates to methods of treating or preventing vascular conditions such as diabetic neuropathy comprising administering a compound capable of epigenetic modification, such as histone deacetylase inhibitors, to a subject in need thereof. In certain embodiments, this disclosure relates to the use of HDAC inhibitors to treat directly diabetic neuropathies and pain without the use of progenitor cells or stem cells. In certain embodiments, the subject is at risk of, exhibiting symptoms of, or diagnoses with diabetes, diabetic neuropathy, peripheral neuropathy, autonomic neuropathy, radiculoplexus neuropathy, mononeuropathy, diabetic retinopathy, or complications related thereto. In certain embodiments, the compound is selected from belinostat, quisinostat, and vorinostat.
Patent WO-2020181107-A1 (WO)
Inventor: VAGLE KURT
IPC: C12N15/113
Filed: 2020-03-05
Abstract: Provided herein are synthetic, modified miRNA mimics that increase miRNA activity. In particular, the present disclosure provides synthetic, modified mimics of miR-29, miR-96, miR-182, and miR-183, as well as methods of making and uses thereof.
Patent WO-2020185757-A1 (WO)
Inventor: WANG JINGHUA
IPC: G06T5/50
Filed: 2020-03-10
Abstract: A method for motion correction of Magnetic Resonance (MR) images is provided. The method includes acquiring a k-space dataset for an object using an MR scanner, detecting or identifying corrupted k-space data from the acquired k-space dataset, extracting the corrupted k-space data from the acquired k-space dataset, recovering the corrupted k-space data, combining uncorrupted k-space data of the acquired k-space dataset with the recovered k-space data to form a full k-space dataset, and reconstructing an image for the object based on the full k-space dataset. A magnetic resonance imaging system for correcting corrupted k-space data of an entire k-space dataset is also provided.
Patent WO-2021167629-A1 (WO)
Title: Virtualized hardware and methods for leveraging virtualized hardware with munition support software
Inventor: WALKER BRAD
IPC: G06F11/36
Filed: 2020-03-17
Abstract: An apparatus includes at least one memory (604, 610, 612) configured to store a virtualization associated with a programming and test platform (100, 200) and a munition (102). The virtualization includes a virtual machine (304, 404) containing first software or firmware instructions (310, 410) associated with the programming and test platform and second software or firmware instructions (308, 408) that control behavior of the programming and test platform relative to the munition. The virtualization also includes a virtual representation (312, 418) of the munition. The virtualization further includes one or more virtual communication channels (316, 416) configured to communicatively couple the virtual machine and the virtual representation of the munition. The apparatus also includes at least one processor (602) configured to execute the virtualization and simulate the programming and test platform and the munition on the apparatus.
Patent WO-2020198718-A1 (WO)
Title: Multistage conveyor units for separating parcels
Inventor: SCHROADER STEVEN
IPC: B65G47/30
Filed: 2020-03-27
Abstract: A multistage multi-lane singulator conveyor system for separating side by side packages in stages. A first conveying lane having a high friction surface is combined with a second conveying lane adjacent thereto in lateral flow communication therewith having a lower friction conveying surface including both forward and lateral conveying forces urging parcels forward and away from the first conveying lane. The conveying surface of the second conveying lane may form an inclined plane extending above an inner lateral receiving edge of an adjacent third conveying lane having a high friction surface. Each of the high friction conveying lanes may utilize a plurality of narrow belts to vary the area of the high friction surface. Assembling one or more multi-lanes comprising narrow belts on a conveyor end to end, or assembling multi-lane conveyors end to end provides means to control the residence time and lateral movement of articles.
Patent WO-2020219426-A1 (WO)
Inventor: KADIRI PRASAD REDDY
IPC: H04W36/00
Filed: 2020-04-21
Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive, from a serving cell, signaling identifying a core network type cell ranking offset parameter. The UE may rank, based at least in part on the core network type cell ranking offset parameter, a neighbor cell for reselection relative to the serving cell, wherein the neighbor cell is associated with a different core network type than the serving cell. The UE may selectively reselect to the neighbor cell based at least in part on ranking the neighbor cell for reselection relative to the serving cell. Numerous other aspects are provided.
Patent WO-2021216070-A1 (WO)
Inventor: D'APUZZO FAUSTO
IPC: G01N29/34
Filed: 2020-04-23
Abstract: An example method for measuring deformability of a cell, consistent with the present disclosure, includes detecting a single cell of a biologic sample in a cell probing chamber of a microfluidic device. The method includes isolating the cell in the cell probing chamber of the microfluidic chip by terminating the flow of the biologic sample through the microfluidic chip. The method further includes causing deformation of the cell by introducing ultrasonic waves into the cell probing chamber, and measuring deformability of the cell responsive to the introduction of the ultrasonic waves.
Patent WO-2020227072-A1 (WO)
Inventor: JONES KYLE
IPC: A61P35/00
Filed: 2020-05-01
Abstract: L'invention concerne des polypeptides contenant des VHH qui se lient à CD33. L'invention concerne également des utilisations des polypeptides contenant des VHH.
Patent WO-2020227257-A1 (WO)
Inventor: MARI PEDRO
IPC: H04S3/00
Filed: 2020-05-05
Abstract: An electronic device includes one or more pose sensors for detecting a pose of a user of the electronic device relative to a first physical environment and is in communication with one or more audio output devices. While a first pose of the user meets first presentation criteria, the electronic device provides audio content at a first simulated spatial location relative to the user. The electronic device detects a change in the pose of the user from the first pose to a second pose. In response to detecting the change in the pose of the user, and in accordance with a determination that the second pose of the user does not meet the first presentation criteria, the electronic device provides audio content at a second simulated spatial location relative to the user that is different from the first simulated spatial location.
Patent WO-2021006950-A1 (WO)
Title: Server-side rendered audio using client audio parameters
Inventor: WILSSENS STEVEN
IPC: H04L29/06
Filed: 2020-05-15
Abstract: A server system is provided that includes at least one processor configured to receive a set of client audio parameters from a client computing device, determine a set of audio tuning parameters based on the set of client audio parameters, execute a server-side rendered application program for the client computing device, render a stream of visual data for the server-side rendered application program based on a stream of user input received from the client computing device, render a stream of audio for the server-side rendered application program based on the set of audio tuning parameters, and send the stream of visual data and the stream of audio to the client computing device.
Patent WO-2021029932-A1 (WO)
Inventor: SAMANIEGO RAYMOND
IPC: G06T19/20
Filed: 2020-05-21
Abstract: System and method for generating 3D color representation of 2D grayscale images include: receiving a plurality of 2D grayscale image slices generated by scanning an object; selecting a reference image slice from the plurality of 2D grayscale image slices; selecting a number of additional image slices on either or both sides of the selected reference image slice; generating a 3D representation of the selected reference image slice using the selected number of additional image slices; rendering a 3D representation of the selected reference image slice by spatially colorizing the selected reference image slice; and displaying the 3D representation of the selected reference image slice on a display device. The grayscale image slices may be generated by a scanner using a CT scan image or an MRI image.
Patent WO-2020243604-A1 (WO)
Title: Software-controlled variable wavefront size execution at gpu
Inventor: EMBERLING BRIAN
IPC: G06T15/04
Filed: 2020-05-29
Abstract: A system includes a processor configured to operate in at least a first mode and a second mode. In the first mode the first processor operates to execute an instruction for an entire wavefront before executing a next instruction for the entire wavefront. In the second mode the processor operates to execute a set instructions for a portion of a wavefront before executing the set instructions for another portion of the same wavefront. The system further includes a memory coupled to the processor. The memory is configured to store a shader program for execution by the processor, wherein the shader program includes at least one indication associated with one of the first mode or the second mode. The processor is further to implement one of the first mode or the second mode while executing the shader program responsive to the at least one indication present in the first shader program.
Patent WO-2020247461-A1 (WO)
Inventor: FIORE STEFANO
IPC: A61P29/00
Filed: 2020-06-03
Abstract: La présente invention concerne l'utilisation d'un anticorps anti-récepteur d'IL6 pour traiter une douleur inacceptable chez des sujets atteints de polyarthrite rhumatoïde. Des sujets présentant une douleur inacceptable peuvent avoir, par exemple, une douleur réfractaire ou une douleur réfractaire stricte.
Patent WO-2020247917-A1 (WO)
Title: Unitary plasma separation device
Inventor: CHEELEY ROBERT D
IPC: A61M1/36
Filed: 2020-06-08
Abstract: Devices and methods are provided that permit efficient and selective separation of liquid biological specimens into at least two constituent components to facilitate subsequent quantitative and qualitative analysis on at least one analyte of interest in at least one of the components. For example, a liquid biological specimen separation device includes a base defining a base surface, a collection housing extending away from the base surface to a collection end, a collection membrane disposed on the collection housing adjacent the collection end, and a cap assembly secured to the collection housing. The cap assembly includes a cap defining an aperture therein configured to allow deposition of a liquid biological specimen therethrough, a separation membrane secured to the cap and extending across the aperture, a cap ring rotatably secured about the collection housing, and a tether coupling the cap to the cap ring.
Patent WO-2020264516-A1 (WO)
Inventor: LAKE DONALD
IPC: C04B7/44
Filed: 2020-06-29
Abstract: Described are cementitious reagent materials produced from globally abundant inorganic feedstocks. Also described are methods for the manufacture of such cementitious reagent materials and forming the reagent materials as microspheroidal glassy particles. Also described are apparatuses, systems and methods for the thermochemical production of glassy cementitious reagents with spheroidal morphology. The apparatuses, systems and methods makes use of an in-flight melting/quenching technology such that solid particles are flown in suspension, melted in suspension, and then quenched in suspension. The cementitious reagents can be used in concrete to substantially reduce the CO 2  emission associated with cement production.
Patent WO-2022015304-A1 (WO)
Title: Automated fault uncertainty analysis in hydrocarbon exploration
Inventor: RUEGER ANDREAS
IPC: G01V99/00
Filed: 2020-07-15
Abstract: A system includes a processor and a memory. The memory includes instructions that are executable by the processor to access a plurality of seismic images of a subterranean formation in a first geological area. The instructions are also executable to generate a plurality of fault estimates from each of the plurality of seismic images. Further, the instructions are executable to generate a processed seismic image of the first geological area by normalizing and merging the plurality of seismic images and the plurality of fault estimates. Additionally, the instructions are executable to generate a statistical fault uncertainty volume of the first geological area using the processed seismic image. Furthermore, the instructions are executable to control a drilling operation in the first geological area using the statistical fault uncertainty volume of the first geological area.
Patent WO-2021016081-A1 (WO)
Title: Methods and products for treatment of gastrointestinal disorders
Inventor: SMITH MARK
IPC: A61P37/00
Filed: 2020-07-17
Abstract: Described herein are compositions and methods for the delivery of microbial therapeutics useful for the treatment of disorders related to intestinal dysbiosis. In various aspects, the present invention provides compositions and methods that are useful treating or preventing inflammatory bowel disease (IBD) in a subject in need thereof. For instance, the present invention, in part, relates to a plurality of bacterial isolates, wherein at least two of the plurality of bacterial isolates are isolated from a stool of different human donors.
Patent WO-2021026345-A1 (WO)
Inventor: DYSON THOMAS EARL
IPC: F01D5/28
Filed: 2020-08-06
Abstract: An airfoil includes a multi-part body and one or more thermally conductive pins. The multi-part body has an interior region and is formed from multiple pieces joined with each other at an interface. The pieces have multiple cavities and at least one of the pieces defines airfoil cooling channels disposed within the interior region of the body. The one or more thermally conductive pins are within the interior region of the body and extend across the interface. Each of the thermally conductive pins has a first segment disposed within a corresponding cavity of a first piece of the multiple pieces and a second segment disposed within a corresponding cavity of a second piece of the multiple pieces.
Patent WO-2021034541-A1 (WO)
Inventor: POPOVICH MICHAEL STEPHEN
IPC: B25C1/08
Filed: 2020-08-11
Abstract: Divers modes de réalisation de la présente invention concernent un outil d'entraînement d'élément de fixation alimenté par combustion (1050) comprenant un récepteur de pile à combustible (1860) conçu pour recevoir et venir en prise avec un répartiteur de pile à combustible (1840) d'une pile à combustible, le répartiteur de pile à combustible étant conçu pour distribuer une dose de carburant à partir de la pile à combustible.
Patent WO-2021034642-A1 (WO)
Title: Integrated electric-to-hydraulic conversion machine
Inventor: VAN DE VEN JAMES
IPC: H02K21/24
Filed: 2020-08-14
Abstract: An electric-to-hydraulic conversion machine (100) includes an axial flux electric motor (102) and a hydraulic pump (104). The motor includes a spindle (110), at least one rotor (108, 208) configured to rotate about the spindle, and at least one stator (106, 206) configured to drive rotation of the at least one rotor about the spindle. The hydraulic pump includes a piston block (114) having a plurality of cylinders (140), a plurality of pistons (142) each supported in one of the cylinders of the piston block, and a cam ring (112). The piston block is attached to the at least one rotor and is configured to rotate about the spindle with rotation of the at least one rotor. The cam ring is configured to radially drive the pistons during rotation of the piston block about the spindle, which drives a fluid flow.
Patent WO-2021046078-A1 (WO)
Title: Comb polymer and block copolymer stabilized nanoparticles encapsulating nucleic acids and other soluble hydrophilic compounds
Inventor: PAGELS ROBERT
IPC: A61K9/51
Filed: 2020-09-02
Abstract: A precipitation route to form nanoparticles with a hydrophilic core containing water soluble materials and a hydrophobic shell is described. The process requires a stabilizing polymer composed of more polar and more non-polar regions. These regions can be arranged as a linear block copolymer, or as a comb polymer with a linear or branched polar backbone and non-polar side chains or substituents. Nucleic acids, including DNA and RNA, as well as proteins, peptides, and polysaccharides or combinations can be encapsulated in the nanoparticle core. The encapsulation of nucleic acids can require partially or fully neutralizing the acid with a base to enhance the solubility of the nucleic acid in the process solvent stream. The core or the shell of the resulting nanoparticles can be crosslinked. The nanoparticles may be coated with additional polymer to bring them into water, or processed into microparticles or larger monoliths.
Patent WO-2021046449-A1 (WO)
Title: Real-time morphing interface for display on a computer screen
Inventor: YUE SHENG
IPC: G10L15/26
Filed: 2020-09-04
Abstract: A morphing interface system updates, that is, morphs, a display on a client device as a user provides portions of input. The system receives a first portion of user input and selects an intent related to a predicted intent of the user that matches or can be associated with the portion of user input. The system displays an interface associated with the intent at the client device. The system additionally extracts entity values associated with execution of the intent from the first portion of the user input. As the user provides additional portions of input, the morphing interface system reevaluates the user input and determines whether the user input still indicates the same user intent, and thus the same intent for execution. Upon determining that the additional input indicates a different user intent, the system updates the display to show an interface associated with the new intent.
Patent WO-2021061830-A1 (WO)
Title: Herbicide resistant plants and methods of making and using
Inventor: MCELROY JOSEPH
IPC: C12N15/82
Filed: 2020-09-23
Abstract: The present disclosure relates to protoporphyrinogen IX oxidase (PPO) polypeptides, and nucleic acids encoding such polypeptides. The present disclosure describes a mutation in a PPO sequence that imparts herbicide-resistance, particularly oxadiazole-resistance, to plants.
Patent WO-2021067188-A1 (WO)
Inventor: KODURI SREENIVASAN
IPC: H01L21/02
Filed: 2020-09-28
Abstract: A microelectronic device (100) has a die (101) with a first electrically conductive pillar (113), and a second electrically conductive pillar (114), mechanically coupled to the die (101). The microelectronic device (100) includes a first electrically conductive extended head (119) electrically coupled to the first pillar (113), and a second electrically conductive extended head (120) electrically coupled to the second pillar (114). The first pillar (113) and the second pillar (114) have equal compositions of electrically conductive material, as a result of being formed concurrently. Similarly, the first extended head (119) and the second extended head (120) have equal compositions of electrically conductive material, as a result of being formed concurrently. The first extended head (119) provides a bump pad, and the second extended head (120) provides at least a portion of a first plate (122) of an integrated capacitor (110). A second plate (109) may be located in the die (101), between the first plate (122) and the die (101), or on an opposite of the first plate (122) from the die (101).
Patent WO-2021067922-A1 (WO)
Inventor: DUMPE SAMUEL C
IPC: A61B34/00
Filed: 2020-10-05
Abstract: Methods and systems for identifying and determining the size and orientation of a reamed portion of a patient's bone are disclosed. A tracking array and/or point probe may be inserted into an adapter device. The adapter device comprising a plurality of openings, having various connection means therein, such that when the tracking array is inserted into the adapter, a secure and robust connection is created. A reamer, stem, or similar tool may then be inserted into the opposing side of the adapter, during which, a secure and robust connection is created between the adapter and the tool. Thus, through the use of Computer Assisted Surgery Systems, a more accurate representation of the patient's anatomy can be obtained.
Patent WO-2021076492-A1 (WO)
Title: Using driver assistance to detect and address aberrant driver behavior
Inventor: SILVER DAVID
IPC: B60W40/09
Filed: 2020-10-13
Abstract: The technology relates to identifying and addressing aberrant driver behavior. Various driving operations may be evaluated over different time scales and driving distances (902, 906). The system can detect driving errors and suboptimal maneuvering, which are evaluated by an onboard driver assistance system and compared against a model of expected driver behavior (908). The result of this comparison can be used to alert the driver or take immediate corrective driving action (912, 914). It may also be used for real-time or offline training or sensor calibration purposes (912, 914). The behavior model may be driver-specific, or may be a nominal driver model based on aggregated information from many drivers. These approaches can be employed with drivers of passenger vehicles, busses, cargo trucks and other vehicles.
Patent WO-2021076539-A1 (WO)
Title: A stinger for a pipe laying operation
Inventor: NAIR SAJITH
IPC: F16L1/225
Filed: 2020-10-14
Abstract: A stinger including a first member formed from a first non-metaliic material, a second body member formed from a second non-metaliic material, and a plurality of cross-support members disposed between the first body member and the second body member. The first body member includes a first lower portion, a first upper portion, and a first intermediate portion disposed between the first lower portion and the first upper portion. A width of the first lower portion is greater than a width of the first intermediate portion and a width of the first upper portion, and wherein the width of the first upper portion is greater than the width of the first intermediate portion. The second body member includes a second lower portion, a second upper portion, and a second intermediate portion disposed between the second lower portion and the second upper portion.
Patent WO-2021080855-A1 (WO)
Title: Device force control
Inventor: SINGLA ASEEM
IPC: G06F1/16
Filed: 2020-10-16
Abstract: The description relates to devices and progressive forces between device portions. In one example, an extent of compression of a compressible material component can affect magnetic attraction between the device portions.
Patent WO-2021081104-A1 (WO)
Title: Systems and methods for detection and staging of pulmonary fibrosis from image-acquired data
Inventor: SMITH ANDREW DENNIS
IPC: G06T7/00
Filed: 2020-10-21
Abstract: A method for ascertaining pulmonary fibrosis disease progression or treatment response includes obtaining a first set of computed tomography (CT) images of a lung and determining a first Pulmonary Surface Index (PSI) score for the lung by detecting a first actual lung boundary of the lung within the first set of CT images, determining a first approximated lung boundary within the first set of CT images, and determining the PSI score using inputs based on the first actual lung boundary and the first approximated lung boundary. The method also includes obtaining a second set of CT images of the lung and determining a second PSI score for the lung using inputs based on a second actual lung boundary and a second approximated lung boundary. The method also includes assessing pulmonary fibrosis treatment response or disease progression based on the first PSI score and the second PSI score.