Patent CA-3088606-A1 (CA)
Title: Humanized and de-immunized antibodies
Inventor: RAHFELD JENS-ULRICH
IPC: C07K16/18
Filed: 2019-01-29
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date                   WO 2019/149689 Al 08 August 2019 (08.08.2019)       WIPO I PCT (51) International Patent Classification:                                           MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, C07K 16/18 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number:   Declarations under Rule 4.17: (22) International Filing Date:                                                     ¨ as to applicant's entitlement to apply for and be granted a 29 January 2019 (29.01.2019)    patent (Rule 4. 17(ii)) ¨                                                                                   as to the applicant's entitlement to claim the priority of the (25) Filing Language:                     English earlier application (Rule 4.17(iii)) (26) Publication Language:                English Published: (30) Priority Data:                         ¨ with international search report (Art. 21(3)) 18154427.1         31 January 2018 (31.01.2018) EP ¨ with sequence listing part of description (Rule 5.2(a)) (71) Applicant: PROBIODRUG AG [DE/DE]; Weibergweg 22, 06120 Halle (Saale) (DE). (72) Inventors: RAHFELD, Jens-Ulrich; Grasemannweg 4, OT Roeblingen am See, 0631'7 Gemeinde Seegebiet Mansfelder Land (DE). GILLIES, Stephen; 4'7 Swanson Lane, Carlisle, Massachusetts 01741 (US). HETTMANN, Thore; Uhlandstrasse 14, 14513 Teltow (DE). SCHIL-LING, Stefan; Glockenweg 4, 06130 Halle (Saale) (DE).  KLEINSCHMIDT, Martin; Schillerstrasse 25, 06114 Halle (Saale) (DE). = (74) Agent: MAIKOWSKI & NINNEMANN PATENTAN-=      WÄLTE PARTNERSCHAFT MBB; P. O. Box 15 09 20, 106'71 Berlin (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, .40! (54) Title: HUMANIZED AND DE-IMMUNIZED ANTEBODIES IT (57) Abstract: The invention relates to humanized and de-immunized antibodies that bind to an epitope at the N-terminus of pyrog-lutamated amyloid beta (A13 N3pE) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyrog-7r lutamated amyloid peptide, like Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy and other related aspects. More --..., specifically, it pertains to the use of monoclonal antibodies of the invention to bind pyroglutamated amyloid beta peptide in plasma, brain, and cerebrospinal fluid to prevent accumulation or to reverse deposition of Ar3 N3pE within the brain and in various tissues in the periphery, and to alleviate amyloidosis. The present invention further pertains to diagnostic assays for the diagnosis of amyloidosis r=11 using the antibodies of the invention.