Patent SG-11201901697Q-A (SG)
Title: Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
Inventor: PAN ZHUO-HUA
IPC: C07K14/705
Filed: 2017-08-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/044912 Al 08 March 2018 (08.03.2018) W I PO I PCT — (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: ELRIFI, Ivor et al.; Cooley LLP, 1299 Pennsylva- C07K 14/405 (2006.01) A61K 35/30 (2015.01) nia Avenue, Suite 700, Washington, District of Columbia C07K 14/705 (2006.01) A61K 35/34 (2015.01) 20004 (US). A61K 41/00 (2006.01) (81) Designated States (unless otherwise indicated, for every International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/049158 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 29 August 2017 (29.08.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/380,871 29 August 2016 (29.08.2016) US TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Applicant: WAYNE STATE UNIVERSITY [US/US]; (84) Designated States (unless otherwise indicated, for every 656 West Kirby, Detriot, Michigan 48202 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Inventor: PAN, Zhuo-Hua; 2140 Lancer Drive, Troy, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Michigan 48084 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (54) AND ,_ 1 preserve, IN Ch R2 CoChR CHANNELOPSIN VARIANTS HAVING IMPROVED LIGHT SENSITIVITY Title: IDENTIFICATION OF MUTATIONS METHODS OF USE THEREOF Figure 1 1.2 — 1.0 . = w . N co O .4 Z 0.2 = = = = _ = _ = = = = = = mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to : The invention provides compositions improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject impaired vision, thereby restoring vision to normal levels. 400 440 480 520 560 600 Wavelength (nm) and kits including at least one nucleic acid or polypeptide molecule encoding for _ 1-1 ei 1-1 cn 0 ii- 71- (57) ---- a GC © having ei O [Continued on next page] WO 2018/044912 Al MIDEDIMOMMIDIREEMOMMEHHOHOEHEEIS MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))