baber/WOPTO huggingface dataset:
Patent NZ-232321-A (NZ)
Title: Disintegratable tablet containing gemfibrozil in two granulation forms to provide both immediate and sustained release
Inventor: GHEBRE-SELLASSIE ISAAC
IPC: A61P3/06
Filed: 1990-01-31
Abstract: A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically acceptable (meth)acrylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
Patent NZ-242351-A (NZ)
Title: 3-aryl oxazolidinone derivatives, preparation and pharmaceutical compositions thereof
Inventor: JARREAU FRANCOIS-XAVIER
IPC: A61P25/00
Filed: 1992-04-14
Abstract: Derivatives having the formula:   <IMAGE> (I)  where R1 denotes C1-C4 alkyl; X denotes oxygen or methylene; R2 denotes C1-C4 alkyl or CF3; R3 denotes a CH2R4 group in which R4 is (i) a pentagonal or hexagonal aromatic heterocyclic group comprising one or two nitrogen atoms and optionally fused with a benzene ring or (ii) a group having the formula  <IMAGE>   where n=0 or 1, and R5 and R6 independently denote C1-C4 alkyl or benzyl, and R5 and R6 also, together with the nitrogen atom to which they are bonded, form a piperidino or pyrrolidino or morpholino or N-methyl piperazino radical, and their N-oxide forms and acid addition salts of these derivatives and their N-oxide forms, the derivatives being in various stereoisomeric forms or in the form of a mixture of these forms, including the racemic form.
Patent NZ-242685-A (NZ)
Title: Rucksack with a hip belt and a wedge-shaped device therebetween
Inventor: PARSONS MICHAEL CHARLES
IPC: A45F3/04
Filed: 1992-05-11
Abstract: At least one device (22, 23) serving as a wedge by having a first end portion which is broader than a second opposing end portion is mounted with its broader end portion uppermost between the or each hip or lumbar pad (10) and the rear of the rucksack (14) so as to press the upper portion of the pad into close contact with a user's back/hip to effect downward transmission of load to the user's hips. <IMAGE>
Patent NZ-243533-A (NZ)
Title: Biocidal composition containing nematodes of the genus phasmorhabditis
Inventor: WILSON MICHAEL JOHN
IPC: A01N63/10
Filed: 1992-07-13
Abstract: PCT No. PCT/GB92/01248 Sec. 371 Date Mar. 8, 1994 Sec. 102(e) Date Mar. 8, 1994 PCT Filed Jul. 9, 1992 PCT Pub. No. WO93/00816 PCT Pub. Date Jan. 21, 1993.Phasmarhabditis nematodes for the biocontrol of agricultural and horticultural pests and more particularly to the biocontrol of molluscs. The nematodes are cultured with a nematode growth-promoting and pathogenicity-inducing bacterium and applied to the molluscs. The molluscs which are biocontrolled by the disclosed method include slugs, i.e. Deroceras reticulatum. In addition to the specific biocontrol of slugs the invention is applicable to the biocontrol of other molluscs, such as snails, i.e. Monacha cantiana, which are harmful to plants in the field or greenhouse, or to those which carry parasites harmful to humans or animals.
Patent NZ-246687-A (NZ)
Title: Morphinan derivative and pharmaceutical compositions thereof
Inventor: NAGASE HIROSHI
IPC: C07D401/12
Filed: 1993-01-22
Abstract: A morphinan derivative represented by the general formula (I) or its pharmacologically acceptable acid addition salt: <CHEM> wherein R<5> is a specified cyclic ring, B is C1-14 alkylene and A is -XC(=Y)-, -XC(=y)z-, -X-, -XSO2- or -OC(OR<4>)(R<4>)- (where X is NCH3, NH, S or O, but is other than NCH3 when R<6> and R<7> together form -O-, each A, Y and Z, independently, is NR<4>, S or O and R<4> is H, C1-5 alkyl or C6-12 aryl) have analgesic activity.
Patent NZ-248662-A (NZ)
Title: Fuel dispenser with vapour recovery pump control
Inventor: PAYNE EDWARD ASBELL
IPC: B67D7/32
Filed: 1993-09-14
Abstract: A fuel dispenser comprises a fuel delivery pump (8), a separate vapor recovery pump (44) and control means (50) responsive to signals from sensors for identifying an error condition and preventing further vapor recovery which could result in an air rich explosive mixture in the vapor recovery system including an associated fuel storage tank. <IMAGE>
Patent NZ-256342-A (NZ)
Title: Aquaculture system apparatus and method involving monitoring and adjusting parameters on a continuous basis, the parameters being essential to the growth of a primary cultured species, and secondary organisms essential for its growth, in the system
Inventor: FAHS RICHARD W
IPC: A01K63/00
Filed: 1993-09-20
Abstract: The present invention is directed to apparatus and a method for maintaining and growing a primary cultured species and secondary organisms essential to the growth of the primary species in an aquaculture system in which the parameters which affect the maintenance and growth of the primary cultured species are carefully monitored and adjusted on a substantially continuous basis. The apparatus comprises a tank for holding an aqueous medium and the primary species, nutrient supply equipment, equipment for selectively removing the aqueous medium from the tank, apparatus for removing particulate matter from the aqueous medium removed from the tank, a sterilizer for sterilizing the aqueous medium removed from the tank, equipment for removing toxins from the aqueous medium removed from the tank without biological filtration, and a station with associated equipment for bringing the aqueous medium to a steady state suitable for the growth and survival of the primary species. Conduits, pumps and associated valving are provided for transferring the aqueous medium among the various treatment stations and for returning the aqueous medium to the tank after it has been treated by any or all of the foregoing treatment equipment.
Patent NZ-262615-A (NZ)
Title: Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies
Inventor: BURKLY LINDA
IPC: C07K16/28
Filed: 1994-02-09
Abstract: A method for the prevention of insulin dependent (type I) diabetes. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4.
Patent NZ-295586-A (NZ)
Title: Method of reducing by-products in a circulating water system using a n-hydrogen compound and a slimicide, use in a paper-making process
Inventor: SWEENY PHILIP GERDON
IPC: C02F1/50
Filed: 1995-10-13
Abstract: Free halogen sources (e.g., sodium hypochlorite and chlorine) added as slimicides in high organic component process streams such as pulp and paper processing are rendered more efficacious by the addition of selected N-hydrogen compounds (namely, 5,5-dimethylhydantoin, 5-ethyl-5-methylhydantoin, cyanuric acid, succinimide, urea, 4,4-dimethyl-2-oxazolidinone, and glycouril) to the process stream. The latter compounds may be added to the process stream before or after the slimicide is added or combined with the slimicide and added directly thereto. The direct use of halogenated hydantoins has also been found to provide improved efficacy relative to free halogen sources. In addition, absorbable organic halogen by-products are reduced.
Patent NZ-304310-A (NZ)
Title: Apparatus for dispensing a fine spray of liquid particles
Inventor: BOLTON TERENCE WILLIAM
IPC: B43K8/00
Filed: 1996-03-21
Abstract: PCT No. PCT/EP96/01225 Sec. 371 Date Apr. 14, 1998 Sec. 102(e) Date Apr. 14, 1998 PCT Filed Mar. 21, 1996 PCT Pub. No. WO97/03757 PCT Pub. Date Feb. 6, 1997Apparatus for dispensing a fine spray of liquid particles comprises a hollow tubular casing (1) whose internal cross section is formed with at least one abutment surface. A tubular liquid source (2) is positioned within the casing (1) with the abutment surface in close contact with the outer surface of the source to provide support thereto. The casing (1) includes a passageway for the flow of air from a mouthpiece (3) positioned at one end of the casing (1) to a nozzle (9) positioned at the other end of the casing (1) into which the discharge end of the liquid source protrudes. The liquid source may comprise a pen formed with a nib (14) of absorbent material.
Patent NZ-334805-A (NZ)
Title: Fructan derivatives
Inventor: KUZEE HENDRIKA CORNELIA
IPC: C08B37/18
Filed: 1997-09-30
Abstract: A fructan derivative, characterised in that it contains, per monosaccharide unit, on average at least 0.1 cationic group of the formula -A-N+KIR2R3 or -C(=NR4)-NR1R2 wherein: A represents a straight-chain or branched alkylene group which is optionally preceded by a carbonyl group or optionally interrupted by one or two oxygen atoms or imino or alkylimino groups and optionally substituted by one or two hydroxyl groups or amine groups or a carboxyl or carbamoyl group; or A represents the residue of a monosaccharide unit; R1 and R2 each represent hydrogen methyl, carboxymethyl, phosphonomethyl, ethyl, hydroxyethyl, propyl, isopropyl, allyl, hydroxypropyl or dihydroxypropyl or, together with the nitrogen atom to which they are bound, form a pyrrolidino, piperidino, piperazino, N'-alkylpiperazino, N'-(hydroxyalkyl)piperazino, N'-(aminoalkyl)piperazino, morpholino or hexamethyleneamino group; R3 represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aralkyl or a group of the formula -A-Fruc, wherein A has the above-mentioned meaning and Fruc represents a fructan residue bonded via oxygen; and R4 represents hydrogen, methyl, ethyl, hydroxyethyl, hydroxypropyl or dihydroxypropyl; where the amine nitrogen atoms can be uncharged or protonated or quaternised with methyl, ethyl, hydroxyethyl, hydroxypropyl or dihydroxypropyl. The fructan derivatives are prepared by reacting a fructan or a derivative thereof with a compound of the formula X-A-N+R1R2R3 (X = chlorine or bromine) or X-A-NR2R3 or an epoxide corresponding thereto after removal of HX, or with NC-NR1R2R3. The fructan derivatives are useful as an auxiliary in papermaking, water treatment, sludge treatment, or in cosmetics, or as a disinfectant, hair conditioner, flocculant, shale inhibitor, corrosion inhibitor, demulsifier, adhesive or textile auxiliary, or as an additive in building, ceramics or plastics.
Patent NZ-500727-A (NZ)
Title: Preparation of benzoxazinones by adding acetonitrile and p-toluenesulfonic acid with heat
Inventor: PIERCE MICHAEL E
IPC: C07C215/68
Filed: 1998-04-02
Abstract: A process for the preparation of asymmetric synthesis of (S)-6-chloro-4-cycpropylethynynl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of Formula (II-i) comprising:  (1) heating an acetonitrile solution of substituted aniline of Formula (XII) and p-toluenesulfonic acid to a temperature of 65oC to 85oC while stirring; (2) adding acetonitrile solution of a benzyl alcohol of Formula (XIII) over a period of 2 to 10 hours to heated acetonitrile solution of the substituted aniline and p-toluenesulfonic acid; (3) heating and stirring the reaction mixture for about 30 minutes to about 4 hours to give a crude solution of the compound of formula (Il-i); (4) cooling the crude solution of the compound of formula (Il-i); (5) adding seed crystals at a temperature of 20oC to 30oC; (6) slowly adding water while stirring at a temperature of 30oC to 35oC to form a slurry of the crystalline compound of formula (Il-i); (7) stirring the slurry for a reaction time of 2 hours to 12 hours at room temperature; (8) filtering the slurry of crystalline compound of formula (II-i) to isolate the crystalline compound of formula (II-i); (9) washing the crystalline material with a mixture of acetonitrile and water in a volume to volume ratio of about 60:40 to about 40:60; and (10) drying the material under an inert atmosphere at a temperature of 50oC. The compounds are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
Patent NZ-510958-A (NZ)
Title: Polarity independent jumper cables for connecting batteries in parallel
Inventor: COWL JEFFREY DAVID
IPC: H01M10/42
Filed: 2001-04-05
Abstract: Polarity independent battery jumper apparatus for operative connection to a first battery and a second battery, each battery having a positive and negative terminal, the apparatus includes a first terminal pair for connecting to the first battery and a second terminal pair for connecting to the second battery, polarity sensing means for sensing the polarities of the battery terminals and providing a signal representative of the battery polarities. A load sensing means provides a signal indicative of the likely load on the apparatus in response to operative connection between the batteries. A switching means responsive to the signal from the polarity sensing means to make operative electrical connections between battery terminals of like polarity for a predetermined time period dependant on the signal from the load sensing means.
Patent NZ-513642-A (NZ)
Title: Growth differentiation factor inhibitors and uses therefor
Inventor: TOPOUZIS STAVROS
IPC: C12N9/99
Filed: 2000-01-21
Abstract: Inhibitors of GDF proteins, such as GDF-8 or GDF-11, are disclosed. Also disclosed are methods for identifying and using the inhibitors, for example, to generate transgenic animals and to treat a variety of diseases.
Patent NZ-515256-A (NZ)
Title: Automated service scheduling system
Inventor: PACE MARK C
IPC: G06Q10/10
Filed: 2001-11-05
Abstract: An automated system uses a decisioning system to schedule service attendants to service events at patron locations. The decisioning system schedules the events for servicing using various factors to establish the priority of different events. Service attendants are paged by the system to inform them of a service to be provided.
Patent NZ-520661-A (NZ)
Title: Method for detecting and quantifying adenovirus
Inventor: VIDAUD MICHEL
IPC: G01N33/569
Filed: 2001-02-07
Abstract: A method for detecting adenovirus nucleic acid in a biological sample comprising: producing an amplification product by amplifying an adenovirus nucleotide sequence by real-time PCR using degenerate sense primers and degenerate antisense primers, wherein said primers are chosen from oligonucleotides that hybridize, under conditions suitable for a polymerase chain reaction, with a sequence between nucleotides 21000 and 22000 of type 5 adenovirus sequence; and detecting said amplification product by using a nondegenerate probe comprising an oligonucleotide that hybridizes, under conditions suitable for a polymerase chain reaction, with a sequence between nucleotides 21000 and 22000 of type 5 adenovirus sequence.
Patent NZ-520837-A (NZ)
Title: Prodrugs of imidazopyridine derivatives
Inventor: SENN-BILFINGER JORG
IPC: C07D491/147
Filed: 2001-03-28
Abstract: Imidazopyridine derivative compounds of formula (1) that are suitable for the prevention and treatment of gastrointestinal diseases are disclosed, wherein the substituents are as defined in the specification.
Patent NZ-521870-A (NZ)
Title: Aminopyridines and their use as anticonvulsants and sodium channel blockers
Inventor: HOGENKAMP DERK J
IPC: A61P23/02
Filed: 2001-03-29
Abstract: A compound of formula I or a pharmaceutically acceptable salt, prodrug or solvate, wherein: R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, cycloalkyl, amino, aminoalkyl, hydroalkyl, alkoxyalkyl, alkoxy, alkylthio, alkylsulfinyl, carboxyalkyl, cyano, alkylamino, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, alkylcarbonyl, heterocyclocarbonyl, aminosulfonyl, alkylaminosulfonyl and hetercyclosulfonyl, all of which can be optionally substituted; R2 is hydrogen or C1-6 alkyl and R3 is hydrogen, or R2 and R3 form a bond; R4 is hydrogen or C1-6 alkyl; R5, R6. R7 and R8 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroalkyl, hydroxyl, nitro, amino, aminoalkyl, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; X is on of O, S, NR9 or CH2 wherein R9 is hydrogen or alkyl; and m is 0-3; and the use of the compound in the preparation of a medicament for treating a disorder responsive to the blockade of sodium channels; or for treating, preventing or ameliorating neuronal loss following global and focal ischemia, neurodegenerative conditions, pain or tinnitus, manic depression, arrhythmias, convulsions or providing local anesthesia; or alleviating or preventing seizure activity.
Patent NZ-524115-A (NZ)
Title: Oral fast-melt dosage form of the cyclooxygenase-2 inhibitor valdecoxib
Inventor: KARALI TUGRUL T
IPC: A61P25/28
Filed: 2001-08-17
Abstract: An oral fast melt composition comprises valdecoxib - 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide dispersed in a matrix comprising a saccharide of low moldability and a binding agent selected from gums, polypeptides, natural and modified starches, cellulosic materials, alginic acid and salts thereof, polyethylene glycol, polyvinylpyrrolidone, polymethacrylates, silicate salts and bentonites.
Patent NZ-524423-A (NZ)
Title: A composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
Inventor: CARRARA DARIO
IPC: A61K47/08
Filed: 2001-08-03
Abstract: A pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprises an active agent and a permeation enhancer. The active agent is i) an androgen hormone or ii) a sedative or anxiolytic of the type benzodiazepine or amide such as butoctamide, diethylbromoacetamide, isovaleryl-diethylamide and the permeation enhancer is a combination of a) saturated fatty alcohol of formula CH3-(CH2)n-CH2OH or saturated fatty acid CH(CH2)n-CH2COOH or unsaturated fatty alcohol of formula CH3(CnH2(n-1))-OH and n is 8 to 22; b) a ternary vehicle or carrier consisting of a C1-4 alkanol, a polyalcohol and water and c) optionally a monoalkylether of diethyleneglycol or the active agent is iii) antihypertensive agents and a permeation enhancer is a combination of: a) saturated fatty alcohol of formula CH3-(CH2)n-CH2OH or saturated fatty acid CH(CH2)n-CH2COOH and n is 8 to 22; b) a ternary vehicle or carrier consisting of a C1-4 alkanol, a polyalcohol and water and c) optionally a monoalkylether of diethyleneglycol or the active agent is iv) an anti-inflammatory agent and the permeation enhancer is a combination of: a) saturated fatty alcohol of formula CH3-(CH2)n-CH2OH or saturated fatty acid CH(CH2)n-CH2COOH or unsaturated fatty alcohol of formula CH3(CnH2(n-1))-OH or unsaturated fatty acid of formula CH3-(C2H(2n-1))-COOH and n is 8 to 22; b) a ternary vehicle or carrier consisting of a C1-4 alkanol, a polyalcohol and water and c) a monoalkylether of diethyleneglycol.
Patent NZ-524535-A (NZ)
Title: Self-sealing valve
Inventor: LANGHOUT VAN ZIJLL
IPC: B65D47/20
Filed: 2001-09-05
Abstract: Shut-off valve, composed of a container (3) provided with valve seat (4), and also a valve body (2) that can be moved through the opening bounded by the valve seat (4), in order to provide a seal. The valve body (2) is provided with a conical or spherical shut-off edge and is connected to the container (3) by way of a flexible connecting part (5). This makes it possible to move the valve body (2) laterally, in other words perpendicular to the direction of closing, and in this way achieve an opening of the shut-off valve. The container (3) can comprise any construction known in the prior art.
Patent NZ-525357-A (NZ)
Title: Convective power generating method and device
Inventor: ABE TOSHIHIRO
IPC: F03G6/04
Filed: 2000-10-27
Abstract: A method of generating power by forcefully forming an ascending air current flow channel and a descending air current flow channel in a closed zone having a gas sealed therein, producing whirling currents by the synergistic effect of the two flow channels, and rotating a turbine by the whirling currents, wherein the power generating efficiency is increased, and a device for realizing the same. A cylindrical rotor (2) is installed between the ascending air current flow channel and the descending air current flow channel, thereby forming the whirling currents and rotating fans (3, 4). Depending on circumstances, a second cylindrical rotor (12) is installed between the ascending air current flow channel and the partition wall isolating the closed zone from the outside, thereby reducing the friction between the ascending and descending air currents. And the method is useful for generating power, e.g., by harnessing the temperature differences produced in the natural world.
Patent NZ-530123-A (NZ)
Title: Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release properties
Inventor: SCHMITKE JENNIFER L
IPC: A61K47/18
Filed: 2002-06-24
Abstract: Disclosed are particle formulations having superior manufacturing and stability properties, comprising 1,2-dipalmitoyl phosphatidylcholine (DPPC), insulin and sodium citrate. The particle formulations are used in the manufacture of a medicament for treating diabetes mellitus.
Patent NZ-531785-A (NZ)
Title: Treatment of glial tumors with ionotropic glutamate receptor antagonists
Inventor: NEDERGAARD MAIKEN
IPC: A61K31/195
Filed: 2002-08-20
Abstract: Disclosed is a use of an ionotropic glutamate receptor antagonist in the preparation of a medicament for treating a glial tumor (which may be located in the brain or spinal cord of a subject) and preventing spread of tumor cells in a subject wherein the medicament is formulated to provide the ionotropic glutamate receptor antagonist at a lower dose than that which causes direct cytotoxicity.
Patent NZ-534909-A (NZ)
Title: A method of assaying the antioxidant activity of oils and lipids using SIFT-MS technology
Inventor: SENTHILMOHAN SOMASUNTHARAM THA
IPC: H01J49/00
Filed: 2004-08-26
Abstract: The method of assaying the antioxidant activity of oils is disclosed. It comprises: a) preparing an oil in water emulsion by mixing the oil with a surfactant, b) adding an ethane generator substrate to the emulsion, c) adding an oxidative peroxyl solution, d) measuring the ethene produced by introducing an amount of the ethene produced into a stream of an inert gas containing precursor ions, e) ionizing the reactive species to form product ions of the reactive species, f) analyzing the ratio of product ions to precursor ions to provide an absolute concentration of the sample, g) analyzing each trace gas constituent, and h) measuring the amount of ethene produced by flow tube, drift tube, or atmospheric chemical ionization methodologies. The amount of ethene produced is described to be measured by Selective Ion Flow Tube Mass Spectrometry (SIFT-MS). The radical scavenging ability of the oils is determined from their Total Oxyradical Scavenging Capacity (TOSC) values; and the peroxyl radicals are generated by the thermal hydrolysis of AAPH at temperatures between 35oC- 39oC.
Patent NZ-537598-A (NZ)
Title: Injectable depot formulation comprising crystals of iloperidone
Inventor: WIECKHUSEN DIERK
IPC: A61K47/26
Filed: 2003-07-14
Abstract: An injectable depot formulation comprising crystals having Structure (I) wherein R is selected from formula a) or b) and the X50 value of the crystals is from 1 to 200 microns. Depot formulations containing crystals of iloperidone or its metabolite have the following advantages: (i) release of the crystals in plasma can be correlated with the size of the crystals; (ii) absorption of the crystals in plasma can be correlated with the size of the crystals; (iii) the particle size of the crystals can be controlled by crystal engineering and/or milling; and (iv) the crystals are stable upon storage, and stable to sterilization procedures, such as gamma irradiation.