baber/WOPTO huggingface dataset:
Patent NZ-217127-A (NZ)
Title: Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
Inventor: BINDRA J S
IPC: C07K1/00
Filed: 1986-08-07
Abstract: Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues are of the formula:wherein, for example in a preferred embodiment R is t-butyloxycarbonyl, m and n are each 0 or 1, their sum being at least 1; R is cyclohexylmethyl; R<sup>2</sup> is 2-methylpropyl, 2-methyl-2--propenyl, benzyl, 4-chlorobenzyl, 3-chlorobenzyl, 4-methylbenzyl, 4-methoxybenzyl, 3,4-dichlorobenzyl, 2-chlorobenzyl or cyclohexylmethyl; R<sup>3</sup> is hydrogen; R<sup>4</sup> is hydrogen, methyl, 4-aminobutyl, 2-carboxyethyl, 3-(ethoxycarbonyl)propyl or 3-(benzyloxycarbonyl)propyl; W is phenylalanyl, W<sup>1</sup> is histidyl and W<sup>2</sup> is lysyl.These compounds are useful for inhibiting the angiotensinogen cleaving action of the enzyme renin having particular utility in the treatment of hypertension.
Patent NZ-220998-A (NZ)
Title: Sequentially produced multicomponent polymer particles: initial polymer different from subsequent polymer: process and use
Inventor: KOWALSKI ALEXANDER
IPC: C08F285/00
Filed: 1987-07-08
Abstract: Sequentially-produced polymer particles comprising a core bearing at least two lobes may be useful in aqueous binder, coating and adhesive compositions. These sequentially-produced polymer particles may contribute sufficient film-build and ICI viscosity to the compositions such that the amount of thickener or other rheology modifier usually found in binder, coating and adhesive compositions may be reduced or eliminated.
Patent NZ-223039-A (NZ)
Title: Methods of sequencing dna using t7 dna polymerase and a kit therefor
Inventor: TABOR STANLEY
IPC: C12Q1/68
Filed: 1987-12-22
Abstract: The invention relates to methods of DNA sequencing including a method for determining the nucleotide base sequence of a DNA molecule, comprising providing the DNA molecule annealed with a primer molecule able to hybridize to the DNA molecule,   incubating the annealed mixture with a DNA polymerase, except reverse transcriptase, in the presence of four different deoxynucleoside triphosphates and a chain terminating agent which terminates DNA synthesis at a specific nucleotide base, the concentration of all four deoxynucleoside triphosphates at the start of said incubating being sufficient to allow DNA synthesis to continue until terminated by said agent. The DNA products of the incubating reaction are separated according to their size, so that at least a part of the nucleotide base sequence of the DNA molecule can be determined. In a furter embodiment the primer may be extended and labelled prior to the incubating reaction.
Patent NZ-231381-A (NZ)
Title: Chewing gum composition containing a hydrated emulsifier and method of production
Inventor: PATEL MANSUKH M
IPC: A23G/
Filed: 1989-11-14
Abstract: Methods of producing gum and the resulting compositions, containing a hydrated emulsifier, are disclosed. In the preferred embodiment, 2 parts water and 1 part lecithin are blended together to form a gel. The gel is added to the gum composition, preferably after the gum base and the majority of the bulking and sweetening agents are mixed together. The use of a hydrated emulsifier improves initial softness and results in an extended shelf life.
Patent NZ-235531-A (NZ)
Title: Sterilisation test pack includes a chemical and a biological indicator
Inventor: SZU-MIN LIN
IPC: A61L2/28
Filed: 1990-10-01
Abstract: The invention relates to a test pack having a housing defining an inner volume and an opening for communication between the inner volume and the environment outside of the housing. A divider divides the inner volume into two portions. A first portion of the inner volume has an absorber positioned therein to retard passage of the sterilization atmosphere. A chemical indicator to indicate exposure to the sterilization atmosphere may also be positioned within the first portion. The second portion defines a blind reservoir which contains a biological indicator for testing for successful completion of the sterilization procedure.
Patent NZ-241807-A (NZ)
Title: Curculin b, amino acid and dna sequences encoding it and its production.
Inventor: KURIHARA YOSHIE
IPC: A23L27/30
Filed: 1992-03-02
Abstract: Essentially pure curculin B. A process for producing curculin B, comprising: culturing a transformed cell or microorganism containing a recombinant DNA containing a base sequence encoding curculin B, whereby curculin B is produced by said transformed cell or microorganism, and isolating curculin B from said transformed cell or microorganism. A DNA encoding mature or premature curculin B. A process for producing a DNA including a base sequence encoding curculin B, comprising: separating a fraction containing a curculin B mRNA from Curculigo latifolia, preparing a single-stranded DNA from said mRNA using reverse transcriptase, preparing a double-stranded DNA from said single-stranded DNA, inserting said double-stranded DNA into a vector, transforming a host with said vector to produce a cDNA library, and isolating a cDNA encoding curculin B from said library, using one or more synthesized DNA's containing a base sequence coding for a partial amino acid sequence elucidated from curculin A purified from Curculigo latifolia, as a probe.
Patent NZ-246091-A (NZ)
Title: Intrabuccally disintegrating preparation containing an active ingredient, agar, and lactose and/or mannitol
Inventor: MASAKI KATSUHIRO
IPC: A61K9/20
Filed: 1992-12-15
Abstract: A solid preparation soluble in the buccal cavity, which is composed of a sugar comprising lactose and/or manitol and 0.1-1.2 w/w%, based on the sugar, of agar and an active ingredient and has a density of 400-1,000 mg/ml and such a strength as to withstand the handling in the manufacture thereof. It has such a sufficient practical solubility in the buccal cavity that even the aged or children having difficulty in swallowing a solid preparation, such as a tablet, can take it. It has an exceedingly high strength as compared with conventional open matrix structures and hence can withstand satisfactorily carrying and PTP packaging.
Patent NZ-322175-A (NZ)
Title: Peptides which enhance transport across tissues and methods of identifying the same
Inventor: O'MAHONY DANIEL JOSEPH
IPC: C07K14/47
Filed: 1996-11-11
Abstract: A peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in s6itu to a site in an animal, such as into the gastro-intestinal tract. At a predetermined time, the phage which is transported across a tissue barrier is harvested at a harvesting site which is separated from the site of administration by the tissue barrier to select transported phage. This transported phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the site of administration to the harvesting site. The identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.
Patent NZ-334171-A (NZ)
Title: Making printed circuits comprising demarcation with sharp edge cutting tool of different conducting paths in a dielectric film covered by a superficial conductive layer
Inventor: DROZ FRANCOIS
IPC: H01F41/04
Filed: 1996-07-18
Abstract: Disclosed is a printed circuit (21) constructed from a dielectric film (1) coated with one or more conductive metal layers (2). The method of making the circuit comprises a step of marking out the various conductive paths (8) by mechanically machining grooves (7) in said conductive layer. Machining is carried out using a sharp cutting tool (not shown) for cutting grooves between said conductive paths without removing any of the conductive material or driving it downwards. For example, a swaging punch or a cutting table controlling a blade may be used to cut grooves. The method is also suitable for making multi-layer circuits and is particularly useful for producing flexible printed circuits, connectors, etc., as well as inductance coils such as those used in smart cards.
Patent NZ-335002-A (NZ)
Title: Pharmaceutical composition comprising an HIV protease inhibitor and a long chain fatty acid
Inventor: LIPARI JOHN
IPC: A61K31/551
Filed: 1997-11-12
Abstract: A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) an HIV protease inhibiting compound or a combination of HIV protease inhibiting compounds, (b) a pharmaceutically acceptable organic solvent which comprises (i) a pharmaceutically acceptable long chain fatty acid in the amount from about 20% to about 99% by weight of the total solution or (ii) a mixture of (1) a pharmaceutically acceptable long chain fatty acid in the amount from about 20% to about 99% by weight of total solution (2) a pharmaceutically acceptable alcohol in the amount of from about 0% to about 15% by weight of the total solution and, optionally, (c) a surfactant. The composition can optionally be encapsulated in either hard gelating capsules or soft elastic capsules (SEC).
Patent NZ-337792-A (NZ)
Title: Nuclear transfer and use in cloning
Inventor: WELLS DAVID
IPC: A61P19/00
Filed: 1999-09-14
Abstract: A method of nuclear transfer in animal cells, comprising selecting and segregating G1 cells from a proliferating or non-proliferating population of diploid donor cells and transferring a nucleus from such a segregated G1 cell into an enucleated recipient cell, wherein donor cells are selected and segregated by physical picking based on individual cell identification to produce a pure G1 cell population. The method provides certainty as to the stage of the cell cycle of the donor nuclei at the time of embryo reconstruction.
Patent NZ-500451-A (NZ)
Title: Peptide constructs derived from porphyromonas gingivalis protein for use in treating periodontitis
Inventor: SLAKESKI NADA
IPC: C12P21/08
Filed: 1998-04-30
Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium  Porphyromonas gingivalis  associated with periodontal disease. The invention also relates to methods of treating or reducing the prospect of  P. gingivalis  infection.
Patent NZ-501915-A (NZ)
Title: ErbB4 receptor-specific neuregulin known as neuregulin-3 which has a EGF like domain
Inventor: GODOWSKI PAUL J
IPC: C07K19/00
Filed: 1998-06-30
Abstract: A neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds, is disclosed, as are methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain, and an ability to specifically bind ErbB4, and not ErbB2 or ErbB3. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the disclosure.
Patent NZ-506177-A (NZ)
Title: Tractor hydraulic grabbing tool
Inventor: LYDDON JOHN
IPC: B66C1/68
Filed: 1999-01-25
Abstract: An apparatus (2) for grasping one or more objects is disclosed.  The apparatus (2) comprise of a frame (14) with at least one attachment section for attaching the frame to the tractor.  A pair of jaw members (4), each member pivotally mounted on the frame (14), and having an inner clamping edge (5) configured to prevent slipping of the grasped one or more objects with respect to the clamping edge (5), are movable in a common plane to a position where the inner edges (5) are substantially adjacent.  The jaw members (4) are opened and closed by a jaw actuator assembly (24) actuated by a control connection means (26,28,30) that is connected to a tractor operator control. The tractor attachment tool (2) is capable of grasping and lifting a heavy or awkward object, moving it to a new location, and setting it down without the tractor operator leaving the tractor controls.
Patent NZ-508681-A (NZ)
Title: Benzothiepine-1, 1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use
Inventor: FRICK WENDELIN
IPC: C07K5/068
Filed: 1999-05-29
Abstract: Compounds of formula I wherein: R1 is methyl, ethyl, propyl, butyl; R2 is H, OH, NH2, NH-(C1-C6)-alkyl; R3 is a sugar radical, a disugar radical, a trisugar radical, a tetrasugar radical, each optionally being mono- or polysubstituted by a sugar protective group; R4 is methyl, ethyl, propyl, butyl; R5 is methyl, ethyl, propyl, butyl; Z is -(C=O)­-C0-C16-alkyl-, -(C=O)n-C0-C16-alkyl-NH-, -(C=O)n-C0-C16-alkyl-O-, -(C=O)n-C1-C16-alkyl-(C=O)m, a covalent bond; n is 0 or 1;and m is 0 or 1. The benzothiepine 1,1-dioxide derivatives are useful in the treatment of hyperlipidemia as well as arteriosclerosis and gallstones.
Patent NZ-508719-A (NZ)
Title: Hyperpolarized gas transport device with at least one gas chamber and a electromagnet providing a magnetic holding field
Inventor: BOGORAD PAUL L
IPC: A61K49/18
Filed: 1999-06-16
Abstract: A compact portable transport unit (10) for shipping hyperpolarized noble gases and shielding same from electromagnetic interference and/or external magnetic fields includes a means for shifting the resonance frequency of the hyperpolarized gas outside the bandwidth of typical frequencies associated with prevalent time-dependent fields produced by electrical sources. Preferably the transport unit includes a magnetic holding field which is generated from a solenoid (20) in the transport unit (10). The solenoid (20) includes a plurality of coil segments and is sized and configured to receive the gas chamber of a container (30). The gas container (30) is configured with a valve (32), a spherical body (33), and an extending capillary stem (35) between the valve and the body. The gas container (30) or hyperpolarized product container can also be formed as a resilient bag. The distribution method includes positioning a multi-bolus container within the transport unit to shield it and transporting same to a second site remote from the first site and subsequently dispensing into smaller patient sized formulations which can be transported (shielded) in another transport unit to yet another site.
Patent NZ-515496-A (NZ)
Title: Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
Inventor: WEHNER VOLKMAR
IPC: A61P29/00
Filed: 2000-05-06
Abstract: Described are spiroimidazolidine derivatives of the formula I in which E, V, W, X, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders such as arthritis, rheumatoid arthritis, polyarthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis or inflammatory disorders of the central nervous system which comprises administering to a subject in need thereof an effective amount of a composition comprising one or more compounds of the formula I. The compounds of the formula I are also inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy and prophylaxis of illnesses which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell- matrix interactions which are based on interactions of VLA- 4 receptors with their ligands play a part. Also described are processes for the preparation of the compounds of the formula I and pharmaceutical preparations which contain compounds of the formula I.
Patent NZ-515706-A (NZ)
Title: N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same
Inventor: ONO SATOSHI
IPC: C07D311/22
Filed: 2000-06-09
Abstract: An N-alkoxyalkyl-N,N-dialkylamine derivative of formula 1 wherein: the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R1 and R2 are the same or different, and are selected from hydrogen, halogen, a substituted or unsubstituted alkyl, aryl, aralkyl, alkoxy, aryloxy, alkylthio, arylthio, alkenyl, alkenyloxy, amino, alkylsulfonyl, arylsulfonyl, carbamoyl or heterocyclic group, an unprotected or protected amino, hydroxyl or carboxyl group, a nitro group and an oxo group; R3 and R4 are the same or different and represent an unsubstituted or substituted alkyl, cycloalkyl or aralkyl group; each of R5, R6, R7 and R8 are the same or different and represent a hydrogen atom or an alkyl group; m represents an integer of 1-5, and n represents an integer of 1-6, and its use in medicaments for the treatment of neurodegenerative disorders.
Patent NZ-516733-A (NZ)
Title: Pharmaceutical formulations for oral dosing that are dosage forms comprising two or more connected sub-units
Inventor: CLARKE ALLAN J
IPC: A61J3/07
Filed: 2000-07-27
Abstract: A multi-component pharmaceutical dosage form comprising a plurality of drug substance - containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance. The sub-units are connected together in the assembled dosage form by a weld between parts of the assembled dosage form. A dosage form (11) is depicted comprising three sub-units (12), (13), (14) linearly disposed in the assembled dosage form, in an arrangement comprising two end compartments (12), (14) at opposite ends of the line, and one intermediate solid sub-unit (13). The compartments (12) and (14) and the solid sub-unit (13) are substantially cylindrical. The compartments (12) and (14) are substantially tub shaped, i.e. each having a base closed by a base wall (12A), (14A), and each having side walls (2B), (4B) extending upward from the base wall (12A), (14A), and an upper open mouth. Each of the compartments (12) and (14) is made of polyvinyl alcohol polymer by injection moulding.
Patent NZ-517719-A (NZ)
Title: Carboxylic acid derivatives and drugs containing the same
Inventor: SHINODA MASANOBU
IPC: C07D209/42
Filed: 2000-09-29
Abstract: Carboxylic acid derivatives of formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient are disclosed, wherein the variables shown in formula (I) are as defined in the specification.
Patent NZ-518780-A (NZ)
Title: Use of estrogen compounds to reduce levels of amyloid-beta peptides and to treat disorders associated with amyloidosis such as Alzheimer's disease
Inventor: PETANESCA SUZANA
IPC: A61P25/24
Filed: 2000-11-03
Abstract: Methods for evaluating the ability of a test compound to reduce the level of amyloid-beta peptides or reduce the ratio the ration of A-beta-42 to A-beta-40 in vivo are described. The methods comprise treating orchidectomized non-human animals with the test compounds and comparing levels of A-beta or the ratio of A-beta-42 to A-beta-40 with control animals.
Patent NZ-519519-A (NZ)
Title: Radio system with cordless remote press to talk (PTT) transmitter for transmission in simplex mode
Inventor: DAVIES JOHN
IPC: H04B1/38
Filed: 2000-12-15
Abstract: A radio system (1,12,30,33) comprises a radio (1) which has a transmit mode, a cordless remote module (33) in which a press to talk (PTT) switch (34) and transmitter (38) of relatively short range compared with the radio and designed to transmit a signal when the PPT switch is operated, and means for establishing a learning mode process, by which process, means associated with the radio will subsequently recognise the aforementioned signal as an instruction to transmit. Means for establishing the learning process comprises means in the remote module for transmitting a code to the radio and means associated with the radio for storing and subsequently recognising that code.
Patent NZ-519523-A (NZ)
Title: A conduit for plumbing fittings
Inventor: MCCULLOCH MALCOLM GREGORY
IPC: E03C1/20
Filed: 2000-11-09
Abstract: A conduit for plumbing fittings comprising a flexible section (11), a first rigid coupling (12) extending from one end of the flexible section and a second rigid coupling (13) extending from the opposite end of the flexible section, whereby one coupling is adapted for connection to a first plumbing fitting and the other coupling is adapted for connection to a second plumbing fitting to allow passage of a fluid from the first plumbing fitting to the second plumbing fitting.
Patent NZ-522202-A (NZ)
Title: Light compression non-laminated bandage comprising a stretch fabric and optionally an adhesive layer
Inventor: EVANS JOHN CHRISTOPHER
IPC: A61F13/02
Filed: 2001-04-24
Abstract: A bandage is described comprising a weft insertion fabric, in particular a light compression bandage which is a non-laminated and/or single layer bandage comprising a weft insertion fabric or a conformable bandage that essentially consists of a weft insertion fabric. The bandage can be used for treating venous leg, lymphodoema, muscle strain and muscle sprain comprising applying such a bandage. The figure shows the basic structure of the bandage with weft inserts (4) and pillar yarns comprising a first yarn (3) and a second yarn (5).
Patent NZ-522930-A (NZ)
Title: Local anesthetic methods and kits
Inventor: WEBER ECKARD
IPC: A61K31/137
Filed: 2001-05-11
Abstract: Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
Patent NZ-525617-A (NZ)
Title: Method and device for the generation of cyclopropene compounds
Inventor: KOSTANSEK EDWARD CHARLES
IPC: A23B7/152
Filed: 2003-05-01
Abstract: A cyclopropene gas generator 10 has a vessel 12 that contains an aqueous suspension 15 of a cyclopropene/cyclodextrin molecule complex, and a sparge gas nozzle 25 through which gas, from a sparge gas generator disposed proximate the vessel, is bubbled to encourage the rapid and complete liberation of cyclopropene gas from the cyclodextrin carrier. The cyclopropene gas exits from the opening 20 in the top of the vessel. Cyclopropenes are used to inhibit the ethylene response in plants and plant products such as fruits and vegetables. This method enables the economical and efficient treatment of small volume facilities as well as large volume plant facilities such as a warehouse.