Patent SG-11201907032R-A (SG)
Title: Amino pyrimidine compounds useful as ssao inhibitors
Inventor: FAN MENGYANG
IPC: A61K31/506
Filed: 2018-02-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT omit IIl °nolo onm iflo oimIE (10) International Publication Number WO 2018/151985 Al (51) International Patent Classification: A61K 31/506 (2006.01) A61P 1/16 (2006.01) CO7D 239/47 (2006.01) (21) International Application Number: PCT/US2018/017152 (22) International Filing Date: 07 February 2018 (07.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2017/000157 14 February 2017 (14.02.2017) CN PCT/CN2017/117791 21 December 2017 (21.12.2017) CN (71) Applicant: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, Indiana 46285 (US). (71) Applicant (for MG only): LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD [CN/CN]; 780 Cailun Road, Rm. 819, Zhangjiang High Technology Park, Pudong New Area, Shanghai 20000 (CN). (72) Inventors: FAN, Mengyang; c/o Eli Lilly And Compa- ny, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). QIN, Luoheng; c/o Eli Lilly And Company, P.O. Box 6288, Indianaoplis, Indiana 46206-6288 (US). WEI, Yi; c/ o Eli Lilly And Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). ZHOU, Guoqiang; c/o Eli Lil- ly And Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). ZHOU, Jingye; c/o Eli Lilly And Com- pany, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (74) Agent: MYERS, James B. et al.; ELI LILLY AND COM- PANY, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) In (54) Title: AMINO PYRIMIDINE COMPOUNDS USEFUL AS SSAO INHIBITORS 00 1-1 NH 2 1-1 (57) : The present invention provides compounds of the formula below, pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds.