baber/WOPTO huggingface dataset:
Patent AU-723397-B2 (AU)
Title: Recombinant toxin fragments
Inventor: SHONE CLIFFORD CHARLES
IPC: C12P21/04
Filed: 1997-08-22
Granted: 2000-08-24
Abstract: A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.
Patent AU-741543-B2 (AU)
Title: Electrochemical processing of liquid such as water
Inventor: BORWICK ROBERT NORMAN
IPC: C02F1/461
Filed: 1997-09-29
Granted: 2001-12-06
Abstract: A method of electroprocessing liquid such as water comprises providing an electrolyser with cathode and anode chambers, each having respective electrodes. An electric current source is provided for the electrodes. Liquid is passed through an inlet of the cathode chamber (76) and passes from the cathode chamber at least partly to an inlet of the anode chamber (80) with the remainder passing along a further flow path to an outlet (88). Apparatus is provided for carrying out the method including a hydraulic valving arrangement to allow control of flow of liquid from cathode to anode and along the further flow path.
Patent AU-715168-B2 (AU)
Title: Novel enediyne quinone imines and methods of preparation and use thereof
Inventor: DANISHEFSKY SAMUEL J
IPC: C07D491/08
Filed: 1995-12-01
Granted: 2000-01-20
Abstract: A quinone imine enediyne possessing cytotoxic activity towards cancer cells having the general structure:   <IMAGE>   wherein R1, R2 and R3 are independently the same or different and are H, Br, Cl, F, NH2, CO2H, or OH or a linear or branched alkyl, etc.; wherein R4 is H, OH or a linear or branched alkoxy, linear or branched alkoxycarbonyl, etc.; wherein R5 is H, Br, Cl, F, O=, OH or S-SR, or a linear or branched alkyl, etc.; wherein R6 is H, Br, Cl, F, CO2H, OH or S-SR', or a linear or branched alkyl, etc; wherein R7 is H, OH or S-SR'', or a linear or branched alkyl, linear or branched alkoxycarbonyl, linear or branched alkoxy or linear or branched hydroxyalkyl group; and wherein R, R' and R'' are independently the same or different and are a linear or branched alkyl, linear or branched acyl or linear or branched alkoxyalkyl group. Also provided are conjugates of the compound with cleavable peptides and carbohydrates, monoclonal antibodies immunoreactive with cancer cells, compositions comprising the analogues and conjugates, methods of treating tumors and a method of preparing the analogues.
Patent AU-569167-B2 (AU)
Title: Transparent non-vitreous ceramic microspheres
Inventor: LANGE ROGER WAYNE
IPC: E01F9/04
Filed: 1985-07-31
Granted: 1988-01-21
Abstract: Solid, transparent, non-vitreous, ceramic particles useful as lens elements in retroreflective pavement markings characterized by having:A. at least one metal oxide phase; andB. an average minimum dimension of more than 125 micrometers.These particles are formed by various sol gel techniques, one example of which is the chemical gelation of titania sols by first mixing with glacial acetic acid. then with ammonium acetate, followed by formation of microspheres in 2-ethylhexanol. Microspheres of this ceramic composition can have relatively large diameters (e.g. over 200-1000 micrometers) making them quite useful as retroreflective lens elements in pavement marking sheet materials.
Patent AU-678376-B2 (AU)
Title: Novel enzyme granulates
Inventor: KIESSER TORSTEN W
IPC: C12N9/98
Filed: 1993-08-05
Granted: 1997-05-29
Abstract: PCT No. PCT/EP93/02081 Sec. 371 Date Apr. 14, 1995 Sec. 102(e) Date Apr. 14, 1995 PCT Filed Aug. 5, 1993 PCT Pub. No. WO94/04665 PCT Pub. Date Mar. 3, 1994Enzyme granules which comprise in their composition, in addition to the enzyme, water-soluble and water-insoluble fillers, binders and if appropriate other granulating auxiliaries, a formate of an alkali metal or alkaline earth metal and if appropriate reducing sugars being added to them to stabilize the enzyme, are described. All the enzymes customary for detergents and cleaning purposes, in particular alkaline proteases, can be processed into the enzyme granules. A process for the preparation of these enzyme granules and their use in pulverulent detergent formulations are also described.
Patent AU-581924-B2 (AU)
Title: A cell-structured, digital multiplier of semi-systolic construction
Inventor: NOLL TOBIAS
IPC: G06F7/52
Filed: 1985-09-16
Granted: 1989-03-09
Abstract: A digital multiplier which has cells arranged in a plurality of rows and columns wherein the rows are assigned to different groups of partial product bits. Sum paths and carry paths are provided which connect the individual cells to each other and at their ends emit signals from which the product bits are formed. The multiplicand bits are stored intermediately together with the sum and carry signals formed in a row and are simultaneously forwarded to the next row in accordance with a pipelining process. It is desired to obtained the least possible delay in feeding a multiplier bit into all the cells of a row so as to achieve short range transit time of the signals between the output of two consecutive rows and this is achieved with a logic link element which is used to form a partial product bit which is contained in a cell which proceeds the row and in which this partial product bit is added to sum signals and carry signals. One of the cells of the following row contains a full adder which is connected to the output of the logic link with a connection line which is provided with a shift register stage. The invention can be used for integrated circuit for digital data processing.
Patent AU-630141-B2 (AU)
Title: Fibres and material comprising same
Inventor: HANSEN ANDERS STAF
IPC: C04B40/00
Filed: 1989-12-14
Granted: 1992-10-22
Abstract: PCT No. PCT/DK89/00295 Sec. 371 Date Jun. 24, 1991 Sec. 102(e) Date Jun. 24, 1991 PCT Filed Dec. 14, 1989 PCT Pub. No. WO90/06902 PCT Pub. Date Jun. 28, 1990.A method for producing a cement material with reduced development of self-induced cracking, the method comprising: adding to a concrete, mortar or cement mix to which water has been added, an amount of 0.05 to 1% by weight, based on the cementitious materials, of synthetic fiber bundles comprising 10-10,000 filaments per bundle, the filaments consisting essentially of a polyolefin, polyolefin derivative, a polyester or a mixture of the foregoing and having a length of 1-30 mm, a mean transverse dimension of 5-30 um and an aspect ratio of 100 to 1000, the filaments in each bundle being held together by a wetting agent, the wetting agent proving the individual filaments with a surface tension which allows them to become homogeneously dispersed in a concrete, mortar or paste mix with conventional mixing in conventional concrete mixing equipment, mixing the resultant mix for a period of at least 20 seconds to obtain a concrete, mortar or cement mix in which the individual filaments are homogeneously dispersed, and casting the concrete, mortar or paste mix in a configuration.
Patent AU-587397-B2 (AU)
Title: Toothed belt transmission for playfree conversion of rotary motion to rectilinear motion
Inventor: KUSPERT MAX
IPC: F16H57/12
Filed: 1985-08-27
Granted: 1989-08-17
Abstract: A drive mechanism is provided for backlash-free conversion of a rotary motion into a linear motion with the aid of a toothed belt and of a drive gear, in particular for a quick and reproducible positioning of tools or tool tables. At least one gear rack adjustable in one direction is present. Arcuate guides are provided at the two sides of the drive gear. The arcuate guides maintain the toothed belt in such engagement with the gear rack that one section receives the load and only a short, defined section of the toothed belt is disengaged from the teeth. Furthermore, the toothed belt is provided as an endless loop.
Patent AU-754686-B2 (AU)
Title: Method for triggering apoptosis in cells
Inventor: ROTHBARTH KARSTEN
IPC: C12N15/12
Filed: 1999-06-02
Granted: 2002-11-21
Abstract: The invention relates to a method for triggering apoptosis, whereby the C1D gene in cells, more particularly, in tumor cells, is overexpressed. This occurs, for instance, by introducing corresponding expression constructs in the cells or by exogenous stimulation of the expression of the cell's own C1D gene.
Patent AU-667585-B2 (AU)
Title: Multi-layered film material
Inventor: HIRAYAMA MASAHIRO
IPC: B32B27/08
Filed: 1993-10-19
Granted: 1996-03-28
Abstract: A multi-layered film material having a structure wherein a protective layer, a composite film comprising a polyvinyl alcohol film or a film of an ethylene/vinyl acetate copolymer saponificate and a silicon oxide deposition layer formed on the former, and a heat-sealable polyolefin layer are laminated. In this case, each of the layers is transparent and the silicon oxide layer is disposed on the side of the protective layer. The protective layer and the composite film, and the composite film and the heat-sealable polyolefin layer are laminated by an adhesive layer, respectively. <IMAGE>
Patent AU-528662-B2 (AU)
Title: Addressing range expansion
Inventor: SATTLER WALTER
IPC: G06F13/00
Filed: 1979-10-19
Granted: 1983-05-05
Abstract: A method and circuit arrangement for expanding the addressing capacity of a central unit, in particular of a microprocessor, beyond the address capacity given by the address stock of an instruction counter provides for the use of at least one base address of the central unit in order to bring about the emission of additional address bits which are combined with the address bits of the base address to form an extension address. The invention may be advantageously practiced in the central unit of a teleprinter private branch exchange.
Patent AU-740550-B2 (AU)
Title: Nut for accommodating the head of a fastening element or for inserting into the same
Inventor: SCHEIWILLER FELIX
IPC: B25B13/44
Filed: 1997-11-05
Granted: 2001-11-08
Abstract: A socket and/or insert (6) for accommodating a fastener head is inserted in a screwing attachment (1). The socket and/or insert (6) comprises two jaws (4, 5) which engage in a tubular holder (3) in which they are locked against rotation. The jaws can slide in axial direction relative to the holder (3). In their one end position, the jaws (4, 5) can be forced apart in radial direction for insertion of a fastener head. Under the effect of axial force in the direction of the arrow (23), the jaws (4, 5) are pressed into the holder (3), whereby the jaws are necessarily squeezed toward each other in radial direction by virtue of the tapered camming faces (12, 13), so that the inserted fastener head becomes firmly clamped.
Patent AU-762171-B2 (AU)
Title: Tear-open spout
Inventor: BENGTSSON BENGT
IPC: B65D5/74
Filed: 2000-06-02
Granted: 2003-06-19
Abstract: A closure for a package that is adapted for mounting to a surface of the package includes a mounting flange having substantially planar upper and lower surfaces that define a thickness and define a flange plane. A spout extends from the upper surface of the flange and has an inner wall defining a dispensing opening. A membrane has a central portion and a circumferential edge region and is formed in the spout so as to extend to the inner wall to define a spout seal. The membrane is severable from the spout at the edge region. The edge region is selectively thinned and has a pair of first thickness regions and a pair of second thickness regions interposed between the first thickness regions. The second thickness regions have a thickness that is greater than a thickness of the first thickness regions.
Patent AU-623063-B2 (AU)
Title: Cosmetic sample applicator and method of construction
Inventor: WALLSCHLAEGER GUNNAR J
IPC: B32B3/30
Filed: 1990-05-09
Granted: 1992-04-30
Abstract: A cosmetic sampler comprising a base support, a coating (1) of a cosmetic composition of predetermined thickness disposed upon the base support, a cover (7, 9, 29) and a multiplicity of projections (3) extending through the coating (1) in a direction substantially transverse to the plane of said base support and cover (7, 9, 29) and having a length greater than the thickness of the coating (1). The coating composition is transferable to a user upon lifting up of the cover (7, 9, 29) in order to remove it.
Patent AU-684728-B2 (AU)
Title: Atomizer
Inventor: TAVOR ELHANAN
IPC: B05B17/06
Filed: 1994-02-08
Granted: 1998-01-08
Abstract: Atomizer comprising a liquid inlet (14), a gas inlet (12) arranged to receive a pressurized flow of gas, a liquid flowpath extending from the liquid inlet (14) to a liquid stream outlet, and a curved gas flowpath extending from the gas inlet to a location adjacent the liquid stream outlet and including a supersonic flow region adjacent the liquid stream outlet, whereby supersonic gas flow adjacent the liquid stream outlet produces a shock wave which impinges on a liquid stream passing out through the liquid stream outlet for atomizing the liquid stream. <IMAGE>
Patent AU-745975-B2 (AU)
Title: An implement for automatically milking animals, such as cows
Inventor: LELY ALEXANDER VAN DER
IPC: A01J7/00
Filed: 1999-09-03
Granted: 2002-04-11
Abstract: An apparatus for automatically milking animals, such as cows, comprising automatic milking machine and a milking robot for automatically connecting teat cups to the teats of an animal to be milked. The apparatus is further provided an enclosure having a control room which is accessible to and contains at least part of the milking machine and milking robot. The apparatus further comprises a device for cleaning or disinfecting, or both, an operator who enters the control room. This is accomplished automatically by providing adjacent to, or as part of, the door that enters the control room, a cleaning and disinfecting device which at least contacts the footwear of an operator entering the control room. The door may be turnable about a centrally disposed vertical axis which rotates to provide an entrance and exit from the control room, the bottom of the rotatable door comprising a basin which contains cleaning or disinfectant fluid or both. The enclosure may have one or two milking compartments either side by side or aligned longitudinally, a control room with access to the milking robot or robots and milking machine or machines and a cleaning and disinfecting device adjacent to, or as part of, the entry door and, as a whole, the enclosure may be movable.
Patent AU-679708-B2 (AU)
Title: Particles for binding monovalent cations, use of such particles as well as methods for scavenging and removing sodium and/or potassium ions
Inventor: NOTENBOMER ANNETTE
IPC: A23L5/20
Filed: 1993-11-25
Granted: 1997-07-10
Abstract: PCT No. PCT/NL93/00252 Sec. 371 Date May 28, 1996 Sec. 102(e) Date May 28, 1996 PCT Filed Nov. 25, 1993 PCT Pub. No. WO95/14531 PCT Pub. Date Jun. 1, 1995A method and particles for binding monovalent cations, each of the particles having a nucleus containing a cation exchange material, and applied thereon, a coating comprising a membrane being permeable for monovalent cations, in particular sodium, potassium, ammonium and hydrogen ions. The membrane is essentially not disintegrated during passage through the intestinal tract of humans or animals and wherein the membrane is more permeable for monovalent cations than for bi- or higher valent cations.
Patent AU-575481-B2 (AU)
Title: Oxymethylene copolymer compositions
Inventor: AMANN HERBERT DR
IPC: C08L59/04
Filed: 1986-05-19
Granted: 1988-07-28
Abstract: The formaldehyde emission in the thermoplastic processing of antioxidant containing oxymethylene copolymer molding compositions is reduced considerably if these molding compositions additionally contain on the surface or homogeneously mixed in a specifically defined formaldehyde binding material which contains in the molecule at least two 4,6-diamino-1,3,5-triazin-2-yl groups. In this way there are avoided deposits on the die and odor annoyance.
Patent AU-754435-B2 (AU)
Title: Modified E. coli enterotoxin II signal peptide and a microorganism expressing a fusion protein of said peptide and a heterologous protein
Inventor: KWON SE CHANG
IPC: C07K19/00
Filed: 1999-09-15
Granted: 2002-11-14
Abstract: A heterologous protein is produced by: (i) culturing a microorganism transformed with an expression vector comprising a gene encoding a modified E. coli enterotoxin II signal peptide fused with the heterologous protein to produce and secrete the heterologous protein to periplasm, the modified E. coli enterotoxin II signal peptide being obtained by replacing at least one of the 2nd, 4th, 5th, 12th, 20th, and 22nd amino acids of E. coli enterotoxin II signal peptide of the following amino acid sequence (SEQ ID NO: 1) with another amino acid, with the proviso that at least one of the 2nd and 4th amino acid of the modified peptide is lysine; and (ii) recovering the heterologous protein from the periplasm.
Patent AU-595801-B2 (AU)
Title: Oral pharmaceutical composition
Inventor: JENKINS ANTHONY WILLIAM
IPC: A61K9/26
Filed: 1986-06-03
Granted: 1990-04-12
Abstract: A sustained release, oral pharmaceutical composition in solid unit dosage form, for application to the mucosa of the oral or nasal cavity, comprises compressed, mucosa adhesive cellulose, coated granules, the granules comprising a drug, a higher aliphatic alcohol and a hydrated water soluble hydroxyalkyl cellulose. 
<??>Preferably the composition is in the form of a buccal tablet, especially a kidney shaped buccal tablet. Preferred materials are morphine as the drug, hydroxypropyl cellulose as the mucosa adhesive cellulose, cetostearyl alcohol as the aliphatic alcohol and hydroxyethyl cellulose as the water soluble cellulose. 
<??>The composition has enhanced adherent properties (to the mucosa) and prolongs the bioavailability of the drug.
Patent AU-624724-B2 (AU)
Title: Pyrrolo(2,1-b)thiazole derivatives
Inventor: SUZUKI NORIO
IPC: C07D207/24
Filed: 1990-07-11
Granted: 1992-06-18
Abstract: A novel compound represented by the following formula (I): <CHEM> wherein R1 represents a hydrogen atom, an alkyl group or a cyclic alkyl group; R2 represents a hydroxyl group, an alkoxy group which may have one to three substituents in the alkyl group moiety, an arylthio group which may have one or more substituents in the aryl group moiety, an aryloxy group which may have one or more substituents in the aryl group moiety, an amino group, an alkylamino group or a cyclic amino group which may contain other hetero atoms as ring atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom; R3 represents a hydrogen atom, an alkyl group, an aryl group which may have one or more substituents, or a hetero aryl group which may have one or more substituents; and ----- represents a single bond or a double bond; salts thereof, and pharmaceutical preparations for preventing and treating hepatic diseases containing the compound of the formula (I) or salts thereof as an active ingredient are disclosed.
Patent AU-718795-B2 (AU)
Title: Netrin receptors
Inventor: TESSIER-LAVIGNE MARC
IPC: G01N33/566
Filed: 1998-02-19
Granted: 2000-04-20
Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Patent AU-586270-B2 (AU)
Title: Method and material for prevention of surgical adhesions
Inventor: LINSKY CARY BRUCE
IPC: A61B19/00
Filed: 1986-08-22
Granted: 1989-07-06
Abstract: An absorbable fabric which effectively reduces the incidence of postoperative adhesions when used as a physical barrier at the operative site is a warp knit fabric of oxidized regenerated cellulose or other bioresorbable material. The barrier fabric is particularly characterized by having a density of 8 to 15 mg/cm<sup>2</sup> and an open area porosity of 12 to 20 percent.
Patent AU-588373-B2 (AU)
Title: Raster image memory system
Inventor: WILLEMS THEODORUS HUBERTUS MAR
IPC: G06K15/02
Filed: 1986-09-24
Granted: 1989-09-14
Abstract: Raster image memory (16) (RIM) comprising a bit-map memory (220) for the storage of the bit representation of a whole page to be printed for a raster output scanner (20) (ROS), each memory element corresponding to a position on the page, and it being possible for the raster image memory to be filled by means of a raster image processor(15) (RIP) which is connected via a synchronous raster image bus system (17) (RI bus) to the raster image memory. A logic processing unit (223) is disposed between the raster image bus (17) and the bit-map memory (220), one input of the logic processing unit (223) being connected to the data lines of the raster image bus (17), and the other input of the logic processing unit being connected to the data outputs (226) of the memory (220). A number of modification code lines (221) of the raster image bus (17) is connected to the raster image memory (16), the logic processing unit (223) being able to perform a number of logic operations on the data presented at the inputs of the logic processing unit (223) in response to the signals on the modification code lines (221).
Patent AU-696987-B2 (AU)
Title: Method for the manufacture of a strip of formable steel
Inventor: PRONK CORNELIS
IPC: B21B1/34
Filed: 1996-06-28
Granted: 1998-09-24
Abstract: PCT No. PCT/EP96/02874 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Jun. 28, 1996 PCT Pub. No. WO97/01402 PCT Pub. Date Jan. 16, 1997A method for the manufacture of a strip of formable steel comprises the steps of (i) forming liquid steel by continuous casting into a slab having a thickness of not more than 100 mm, (ii) rolling the slab in the austenitic region into an intermediate slab having a thickness in the range 5 to 20 mm, (iii) cooling the intermediate slab to below the Ar3 temperature, (iv) holding the intermediate slab in an enclosure for temperature homogenisation, (v) rolling the intermediate slab into strip, with at least one rolling pass applying a thickness reduction of more than 50%, at a temperature below Tt and above 200 DEG  C., wherein Tt is the temperature at which 75% of the steel is converted into ferrite, and (vi) coiling said strip at a temperature above 500 DEG  C. Advantages of simplicity of the method and the plant required for it are obtained.