Patent SG-11201808457P-A (SG)
Title: Icos ligand variant immunomodulatory proteins and uses thereof
Inventor: SWANSON RYAN
IPC: C07K14/705
Filed: 2017-04-14
Abstract: 19) (43) 19 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) World Intellectual Property -, Organization 111111110111101110101011111010111110111011111111011101011111101111101111011111 International Bureau ... .1 j ..... ...... (10) International Publication Number International Publication Date WO 2017/181148 A2 October 2017(19.10.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) Applicant: ALPINE (72) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 14/705 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/US2017/027811 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 14 April 2017 (14.04.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Priority Data: ZA, ZM, ZW. 62/323,608 15 April 2016 (15.04.2016) US 62/394,745 14 September 2016 (14.09.2016) US (84) Designated States (unless otherwise indicated, for every 62/410,842 20 October 2016 (20.10.2016) US kind of regional protection available): ARIPO (BW, GH, 62/472,568 16 March 2017 (16.03.2017) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/475,162 22 March 2017 (22.03.2017) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, IMMUNE SCIENCES, INC. DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [US/US]; 201 Elliott Ave. West, Suite 230, Seattle, WA LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 98119 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Inventors: SWANSON, Ryan; 201 Elliott Ave. West, GW, KM, ML, MR, NE, SN, TD, TG). Suite 230, Seattle, WA 98119 (US). KORNACKER, Mi- Declarations under Rule 4.17: chael; 201 Elliott Ave. West, Suite 230, Seattle, WA — as to the applicant's entitlement to claim the priority of the 98119 (US). earlier application (Rule 4.17(iii)) Agents: POTTER, Karen et al.; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA Published: 92130-2040 (US). — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) [Continued on next page] (74) Title: ICOS LIGAND VARIANT IMMUNOMODULATORY PROTEINS : Provided herein The immunomodulatory proteins provide therapeutic and methods for making FIG. 13A Soluble vig0 (e.g. vigD4c) Stack. Molecule for a AND USES TlITTIOr tweak's WED THEREOF .. .. dbody d Ago =Ms* (V-Mab) acids encoding such pro - oncological conditions. Com- (54) First vigt) rc Ftrg AO le Secon4 igsF First vIg0 30 Fc - Ab ei GC 7r 11 11 GC 11 IN 1-1 (57) O teins. \" positions are immunomodulatory proteins comprising and using such proteins are provided. utility ICOSL variants variety of immunological and nucleic and WO 2017/181148 A2 IMINIMOMMIDEMMOMEIM10101111MIONEEDIS — with sequence listing part of description (Rule 5.2(a))