baber/WOPTO huggingface dataset:
Patent DE-60034707-D1 (DE)
Inventor: LIN XINLI
IPC: C12N15/09
Filed: 2000-12-28
Granted: 2007-06-14
Abstract: A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The method has two key steps to unfold and then refold the proteins expressed in the inclusion bodies. The first step is to raise the pH of the protein solution in the presence of denaturing agents to pH greater than 9, preferably 10. The protein solution may be maintained at the elevated pH for a period of up to about 24 hours, or the pH immediately decreased slowly, in increments of about 0.2 pH units/24 hours, until the solution reaches a pH of about 8.0, or both steps used. In the preferred embodiment, purified inclusion bodies are dissolved in 8 M urea, 0.1 M Tris, 1 mM glycine, 1 mM EDTA, 10 mM beta-mercaptoethanol, 10 mM dithiothreitol (DTT), 1 mM redued glutathion (GSH), 0.1 mM oxidized glutathion (GSSG), pH 10. The absorbance at 280 nm (OD280) of the protein solution is 5.0. This solution is rapidly diluted into 20 volumes of 20 mM Tris base. The resulting solutin is adjusted to pH 9.0 with 1 M HCl and is kept at 4° C. for 24 hr. The pH is adjusted to pH 8.8 and the solution is kept at 4° C. for another 24 hrs. This process is repeated until the pH is adjusted to 8.0. After 24 hr at pH 8.0, the refolded proteins can be concentrated by ultrafiltration and applied to a gel filtration column for purification.
Patent DE-60036437-D1 (DE)
Inventor: BRUCE CHRISTOPHER IAN
IPC: A01N43/56
Filed: 2000-06-29
Granted: 2007-10-31
Abstract: Combinations of avermectins and milbemycins and their derivatives with bis-aryl compounds and their use in combating parasite, especially helminth, infections.
Patent DE-60038177-D1 (DE)
Inventor: SILVERBROOK KIA
IPC: G06F3/0354
Filed: 2000-06-30
Granted: 2008-04-10
Abstract: Methods and systems are disclosed which relate to online banking via interface surfaces printed with information and coded data. The coded data, encoded visibly or invisibly, may be queried by an appropriate sensing device. The sensing device communicates with a computer system. Together, the interface surfaces, sensing device and computer system are capable of effecting banking transactions over a network.
Patent DE-60039017-D1 (DE)
Inventor: NGUYEN MY T
IPC: C08K5/29
Filed: 2000-11-13
Granted: 2008-07-10
Abstract: A component to control the viscosity of phase change material formulations is made by reacting selected nucleophiles, including fatty acid/alcohol reactants with an isocyanate, is disclosed. The addition of the isocyanate and the different nucleophiles will create a viscosity modifying component of low viscosity that can be formulated with higher molecular weight polyamide resins to achieve increased toughness in phase change solid imaging materials and carrier compositions used to make phase change ink jet inks.
Patent DE-60039421-D1 (DE)
Inventor: DENSHAM DANIEL HENRY
IPC: C07K17/02
Filed: 2000-04-06
Granted: 2008-08-21
Abstract: The present invention pertains to a method for polynucleotide synthesis, comprising the steps of: (i) reacting a polynucleotide processive enzyme, e.g., a polymerase or TdT, with a nucleotide substrate under conditions suitable for enzyme activity; and (ii) modulating the conformation of the enzyme, e.g. using radiation, to allow incorporation of a predetermined nucleotide.
Patent DE-60041483-D1 (DE)
Inventor: YUEN KAYE KIT-HAN
IPC: B01J4/00
Filed: 2000-02-23
Granted: 2009-03-19
Abstract: Disclosed is a geometric lockout coupler assembly comprising a probe capable of reversibly moving between an open position and a closed position, the open position permitting fluid to pass through the probe; and a bung cup sized and configured to accept the probe. The probe further comprises a geometric configuration which cooperates with the complementarily shaped bung cup to allow fluid to flow through the probe while not permitting other probes to cooperate with the bung cup.
Patent DE-60041667-D1 (DE)
Inventor: VALLOT LAWRENCE C
IPC: G01C19/56
Filed: 2000-08-04
Granted: 2009-04-09
Abstract: The method involves obtaining high data rate vibration samples and estimating vibration power spectral density. The estimates are combined with previously determined calibration coefficient, for generating real time vibration induced error correction. Independent claims are also included for the following: (a) Recording medium; (b) Calibration coefficient providing system; (c) Vibration induced sensor error compensating system; (d) Coefficient calculating method for inertial sensor.
Patent DE-60045687-D1 (DE)
Inventor: WILSON DAVID F
IPC: G01J1/58
Filed: 2000-10-13
Granted: 2011-04-14
Abstract: A method is described for determining the effect of a drug or drugs on an attached culture of cells comprising (i) dissolving the phosphorescent compound, of known or predetermined quenching constant and lifetime at zero oxygen, in a culture medium at a selected temperature comprising an attached culture of test cells; (ii) introducing the drug(s), whose effect on the test cells is to be determined, into the culture medium; (iii) illuminating the culture medium with pulsed or modulated light at a level sufficient to cause the phosphorescent compound to emit measurable phosphorescence; (iv) measuring the emitted phosphorescence; and (v) calculating the phosphorescence lifetime and oxygen concentration gradient in the medium, thereby determining the effect of the drug on the respiration rate of the cells at the selected temperature. Apparatus for carrying out the method is also disclosed.
Patent DE-60100150-D1 (DE)
Inventor: IGARI YUTAKA
IPC: A01N25/28
Filed: 2001-01-05
Granted: 2003-05-08
Abstract: A microcapsule (or microencapsulated product) having a uniform and smooth coating film and also an excellent performance of gradually liberating the content material is produced at a good particle size distribution while suppressing the occurrence of isolated or aggregated film material, aggregated microcapsules and isolated core material. The production process includes: a first coating step of mixing a water-soluble cationic amino resin and an anionic surfactant in the presence of a hydrophobic core material dispersed in an aqueous medium to coat the dispersed core material with a coacervate of the cationic amino resin and the anionic surfactant; and a second coating step of adding an amino resin prepolymer into an aqueous dispersion liquid containing the coated dispersed core material and polycondensating the amino resin prepolymer to further coat the coated dispersed core material with a polycondensate of the amino resin prepolymer. <IMAGE>
Patent DE-60108479-D1 (DE)
Inventor: MC KINNON W
IPC: A61F2/30
Filed: 2001-03-14
Granted: 2005-02-24
Abstract: An acetabular shell liner having a variable rim surface geometry, which improves range of motion of the femoral component within the liner and decreases the incidence of dislocation and subluxation, and methods of making and using the acetabular shell liner. Prosthetic devices, more particularly hip joint prostheses, containing the acetabular shell liner having a variable rim surface geometry are also provided.
Patent DE-60108863-D1 (DE)
Inventor: RASMUSSEN T
IPC: A45C3/02
Filed: 2001-04-10
Granted: 2005-03-17
Abstract: The present invention relates to a carrying case capable of housing the computer during use. A flap arranged in the front wall of the carrying case may be opened whereby the computer is revealed and ready for use. The openable flap in the front wall is hinged to the lower part of the front wall, whereby said flap is capable of being opened to an opening angle in a range between 0 degree and 175 degree and capable of keeping said opening angle or a smaller angle when the opening force is removed. Thereby the flap cannot fall to a position behind the computer taking up extra space. Preferably the flap is provided with closing means whereby the flap will close automatically when an opening force is removed from the flap. In use the computer top part may be opened to reveal the keys and the display is arranged in the angle suitable for the actual user, whereby the flap is opened to a position having a substantially identical opening angle not falling to a table behind the computer.
Patent DE-60110349-D1 (DE)
Inventor: EWINGS PAUL FRANCIS REGINALD
IPC: B65D83/00
Filed: 2001-11-12
Granted: 2005-06-02
Abstract: A cartridge (1) for use with a dispensing gun, the cartridge (1) comprising an external rigid tube (2) having a first end, a second end and a uniform first portion (2a,102a) of substantially uniform cross-section, a nozzle connector (3) at the first end of the rigid tube (2), an internal frangible tube (10) containing material (11) to be dispensed and a piston (30) slidably mounted within the uniform portion (2a) of the rigid tube (2) and adapted to urge the material (11) towards the nozzle connector (3) in use, the uniform portion of (2a,102a) of the rigid tube (2) having an internal cross-sectional area which is greater than that of a circle having a diameter equal to the maximum internal width of the first portion (2a,102a). <IMAGE>
Patent DE-60110720-D1 (DE)
Inventor: HATTORI SHOZO
IPC: B65D6/14
Filed: 2001-10-04
Granted: 2005-06-16
Abstract: A liquid container (1) includes an outer wall (11) constituting a casing; an inner wall (12) constituting an inner bladder for accommodating liquid, the inner bladder having outer shape substantially equivalent to an inner shape of the outer wall, and the inner bladder having a flexibility and being separable from the casing; a pinch-off portion (13) where portions of the inner wall are welded to each other and are pinched by the outer wall to be supported by the outer wall; wherein the inner wall includes a thicker portion having a larger thickness than another portion of the inner wall, at both sides of the welded portion; and a cavity (20a,20b) provided between an outer surface of the thicker portion of the inner wall and an inner surface of a corresponding portion of an inner surface of the outer wall. <IMAGE>
Patent DE-60111228-D1 (DE)
Inventor: ZHANG ZAIHUI
IPC: C07D487/04
Filed: 2001-07-06
Granted: 2005-07-07
Abstract: A method of inhibiting tumor growth is provided, comprising administering an effective dose of a compound of the formula
Patent DE-60111370-D1 (DE)
Inventor: ZOOK D
IPC: C08L63/00
Filed: 2001-03-09
Granted: 2005-07-14
Abstract: A polythioether is provided of the formulawherein R1 is H, C1-6 alkyl, C1-6 alkyl alcohol, C1-6 alkyl substituted with at least one of:-NHR5 wherein R5 is a C1-6 alkyl, R2 is C2-6 alkyl, C6-8 cycloalkyl, C6-10 alkylcycloalkyl, -[-(CH2)r-Q-]s-(CH2)t-, or C1-2 alkyl substituted forms thereof, wherein r is an integer value from 2 to 8, Q is a heteroatom selected from the group consisting of: O, S, -NH- and -NCH3-, s is an integer value from 1 to 5, and t is an integer value from 2 to 10, R3 is H or C1-4 alkyl, R4 is -CH2- or R2, M is a C1-10 alkyl, C6-20 aryl, C6-20 aryl substituted with at least one C1-8 alkyl group, or a N or O heteroatom, Y is C2-20 alkyl, C6-20 cycloalkyl, C6-10 alkylcycloalkyl, or -[-(CH2)r-Q-]s(-CH2-)t-, n is an integer value from 1 to 60, m is an integer value from 1 to 60, and p is an integer value from 1 to 10, wherein the polythioether has a viscosity at 20° C. of less than 1000 poise.
Patent DE-60119959-D1 (DE)
Inventor: COATES ANTHONY ROBERT MILNES D
IPC: A61K39/285
Filed: 2001-11-16
Granted: 2006-06-29
Abstract: The invention relates to pharmaceutical compositions of an approx 60kDa polypeptide (or its encoding nucleic acid molecules) or functionally equivalent molecules or fragments thereof from  Mycobacterium tuberculosis  or related prokaryotes in the treatment of non-cancerous pathological conditions such as autoimmune and allergic disorders.
Patent DE-60122324-D1 (DE)
Inventor: HOJO HIROYUKI
IPC: A63B23/02
Filed: 2001-06-06
Granted: 2006-09-28
Abstract: A balance training apparatus, which is preferably used for training a body balance function and a locomotive function of a user, and for rehabilitation for lumbago prevention, is provided. This apparatus has a seat for the user and a driving unit for driving the seat. The driving unit comprises a drive source and a power transmission unit for converting an output of the drive source into a horse-riding motion, which is a combination of a rectilinear reciprocating motion in a forward and backward direction (X) of the seat, a first pivotal reciprocating motion (thetay) about an axis extending in a horizontal direction substantially perpendicular to the forward and backward direction, and a second pivotal reciprocating motion (thetax) about an axis extending in the forward and backward direction, and transferring the horse-riding motion to the seat.
Patent DE-60124992-D1 (DE)
Inventor: BRESCIANI EDOARDO
IPC: B22D17/14
Filed: 2001-08-16
Granted: 2007-01-18
Abstract: The invention concerns an equaliser for the forced closure of a suction valve in die-casting moulds. It consists of an external body or casing (11), a central thrust piston (16) guided axially on a guide head (17) and a multiplicity of Belleville washers (18) placed concentrically between piston and body. The Belleville washers (18') are set out in groups on several parallel levels defined by spacers, and each group of Belleville washers lies axially with one part on a collar (19) around the thrust piston and the other part on a support washer (20) in the said body. <IMAGE>
Patent DE-60128708-D1 (DE)
Inventor: EDDISON ALAN MARTYN
IPC: E21B31/00
Filed: 2001-09-04
Granted: 2007-07-12
Abstract: A method of freeing stuck objects ( 16 ) from a bore ( 14 ) comprises running a string ( 12 ) into the bore ( 14 ), the string ( 12 ) including a flow modifier, such as a valve, for producing variations in the flow of fluid through the string, and a device for location in the string and adapted to axially extend or contract in response to variations in the flow of fluid through the string. A portion of the string ( 12 ) engages the stuck object ( 16 ). Fluid is then passed through the string while applying tension to the string, whereby the tension applied to the stuck object varies in response to the operation of the flow modifier and the extending or retracting device.
Patent DE-60135069-D1 (DE)
Inventor: MURAYAMA KOUICHI
IPC: C08G63/672
Filed: 2001-07-28
Granted: 2008-09-11
Abstract: To provide a method for producing polyester polyol that can provide a simple process to produce extensively improved production efficiencies and also produce the polyester polyol of stable in quality, an apparatus for producing the polyester polyol produced by the method, a polyester polyol produced by the method, and a polyurethane foam obtained by use of the polyester polyol produced by the method, polyethylene terephthalate and raw polyol are allowed to react in a reaction vessel to produce polyester polyol and also ethylene glycol which is a by-product of the reaction is distilled off and the distillate is modified, for example by reaction with an alkylene oxide, in a modifying vessel so that it can have a predetermined hydroxyl value and then is fed to the reaction vessel again as the raw glycol, to thereby produce the polyester polyol. <IMAGE>
Patent DE-60136238-D1 (DE)
Inventor: CANGINI GIORGIO
IPC: E02F3/36
Filed: 2001-03-23
Granted: 2008-12-04
Abstract: The quick coupling device comprises a bolt element (6) acting as a locking element that is pushed constantly into the engaged condition by springs (7) and in the opposite direction by the temporary interventions of a hydraulic jack (4). The bolt element (6) is provided with two holes (6A,6B) adapted to receive, one the end of an emergency lever (3) for emergency manual disengagement and the other one a safety pin (5) which is retained in the respective hole (6B) by the thrust of a spring. The safety pin (5) can be retracted both hydraulically and manually, at a protruding hook end (5A) thereof with which a lever (11) can be engaged when necessary. <IMAGE>
Patent DE-60141030-D1 (DE)
Inventor: MCDONALD GEORGE WALLACE
IPC: B42D15/04
Filed: 2001-09-13
Granted: 2010-02-25
Abstract: The present invention provides a sheet material ( 2 ) comprising a first fold line and a second fold line, the first and second fold lines being defined by a series of at least partial perforations ( 4,8 ) in the sheet material ( 2 ), wherein there is one or fewer at least partial perforations at an intersection of the first fold line and the second fold line.
Patent DE-60202040-D1 (DE)
Inventor: FERRERO ALBERTO
IPC: B27G11/00
Filed: 2002-09-20
Granted: 2004-12-30
Abstract: The machine for assembly of bottle cork stoppers has an assembly station (12) in which the components (C1,2) to be glued together to form the stopper are fed along parallel paths (30,34) in which their radial faces are spaced. Glue applicators are provided to apply glue to oat least one radial face and the sections are brought together and removed by a discharge feed (14).
Patent DE-60227063-D1 (DE)
Inventor: VECHT ARON
IPC: C09K11/02
Filed: 2002-04-29
Granted: 2008-07-24
Abstract: A phosphor layer for an electroluminescent panel comprises a phosphor powder held in a binder. The binder comprises a mixture of two constituents, one of which is a drying oil or a semi-drying oil or a derivative and the other constituent is a sol-gel precursors. Examples of suitable oils are linseed oil, grape seed oil, sunflower oil and soybean oil. Examples of suitable sol-gel precursors are tetraethyl orthosilicate, boron iso-propoxide, aluminium sec-butoxide titanium iso-propoxide. Metal salts such as metal alkoxides, metal acetates and metal nitrates may be mixed with the sol-gel precursors.
Patent DE-60228068-D1 (DE)
Inventor: HWU PATRICK
IPC: A61K35/12
Filed: 2002-03-08
Granted: 2008-09-18
Abstract: The present invention relates to preventive, therapeutic, and diagnostic compositions and methods employing lymphocytes having T-cell receptors and chimeric receptors. In particular, the invention relates to pre-selected dual-specificity lymphocytes having endogenous T-cell receptors and chimeric T-cell receptors that recognize a strong antigen and tumor associated antigens where the pre-selected population of adoptively transferred lymphocytes is activated by in vivo immunization, thereby increasing the effectiveness of adoptive immunotherapy.
Patent DE-60231930-D1 (DE)
Inventor: KATAGIRI YOSHINOBU
IPC: B05C5/00
Filed: 2002-02-22
Granted: 2009-05-28
Abstract: In curtain coating for multiple layers consisting of a lower most layer (21a), an uppermost layer (21d) and intermediate layer (21b), using coating liquid (11b, 11c) having viscosity more than 300 mPas for one layer or more of multiple layers improves amazingly the curtain coating stability against disturbance such as passing spliced portion of running web (10). The one layer or more layers for which coating liquid (11b, 11c) having viscosity more than 300 mPas is to be used is selected from intermediate layer (21b, 21c). The curtain coating stability is further improved by combining the high viscosity coating liquid for intermediate layer with other technologies such as electrifying web, heating web upstream of coating point and/or keeping web tension higher than some specified value.
Patent DE-60234051-D1 (DE)
Inventor: COHEN MOSHE
IPC: G06F19/00
Filed: 2002-12-10
Granted: 2009-11-26
Abstract: The present invention is of a system, which features bi-directional communication for measuring and transferring medical data and for communication with medical personnel. The apparatus is preferably integrated with at least one of, but more preferably both, audio and video conferencing between an external (home and office) subject and a medical service center. The invention is particularly useful for subjects having some type of medical risk who wish to be supervised by a medical service center, as well as supervision for emergency situations.
Patent DE-60235993-D1 (DE)
Inventor: MOONEY JAMES ARTHUR
IPC: H02K5/173
Filed: 2002-07-10
Granted: 2010-05-27
Abstract: A vibratory motor for a vibratory screening machine including a housing having a main shaft mounting outer shafts at its ends with a slip connection therebetween, bearings mounted on the outer shafts, first lubricant chambers on opposite sides of each of the bearings with a conduit therebetween, eccentric weights on the opposite sides of each bearing in each of the first lubricant chambers, second lubricant chambers outwardly of the first lubricant chambers, ducts between each outermost first lubricant chamber and an adjacent second lubricant chamber, second conduits between the second lubricant chambers, and conduits including the hollow portion of the main shaft and bores in the main shaft and outer shafts for conducting lubricant from the second lubricant chambers to the bearings.
Patent DE-60238217-D1 (DE)
Inventor: RUSERT CRAIG R
IPC: B65B9/20
Filed: 2002-12-18
Granted: 2010-12-16
Abstract: A pre-prepared mesh-film web is used on a conventional vertical form-fill-seal packing machine to form a plurality of mesh-film bags.
Patent DE-60239221-D1 (DE)
Inventor: CARSON WILLIAM W
IPC: B01D71/00
Filed: 2002-11-16
Granted: 2011-03-31
Abstract: A spacer element (1) is disclosed having an integral screen for use in filled cell electrodialysis. The spacer (1) has a continuous portion (2) impermeable to flow and a screen (3) which spans a centrally-located flow treatment region that contains active treatment material, such as ion exchange beads. The screen (3) may perform a structural function, allowing operation at elevated pressure, and may also define a minimum gap between adjacent membranes and enhance mixing along the flow path and at cell boundaries. The spacer element (1) may be configured to enhance hydraulic filling of the cells, and cell architecture is readily implemented in a wide range of useful flow path geometries utilizing the screen spacer element (1).
Patent DE-60239928-D1 (DE)
Inventor: KARASIK VLADIMIR
IPC: H01H25/00
Filed: 2002-04-12
Granted: 2011-06-16
Abstract: A combined windshield front and rear washing and wiping stalk switch having a single contact substrate that is adapted to engage a front wiper carrier, a front wash carrier and a rear wipe/wash carrier. To this end, the multifunctional steering column stalk switch comprises: (i) a housing; (ii) a substrate fixed inside the housing having a first leg and a second leg defining a predetermined angle between the first leg and the second leg; (iii) a conductive trace on one surface of each leg; (iv) a first carrier moveably engaged with the first leg having an electrical contact adapted to engage the conductive trace on the first leg; (v) a second carrier moveably engaged with the second leg having an electrical contact adapted to engage the conductive trace on the second leg; (vi) a first manual input device adapted to move the first carrier with respect to the first leg; and (vii) a second manual input device adapted to move the second carrier with respect to the second leg.