baber/WOPTO huggingface dataset:
Patent CR-20150536-A (CR)
Title: Sistemas y métodos para el análisis con dispositivo móvil de ácidos nucleicos y proteínas
Inventor: GOEL ANITA
IPC: B01L3/00
Filed: 2015-10-13
Abstract: Se proporciona un sistema portátil para extraer, opcionalmente amplificar y detectar ácidos nucleicos o proteínas usando un chip integrado compacto en combinación con un sistema de dispositivo móvil para analizar las señales detectadas y comparar y distribuir los resultados por medio de una red inalámbrica. Se proporcionan sistemas y métodos relacionados.
Patent CR-20150571-A (CR)
Title: Compuestos y composiciones terapéuticos
Inventor: CIANCHETTA GIOVANNI
IPC: C07D417/12
Filed: 2015-10-15
Abstract: Se describen en la presente compuestos de fórmula general I y composiciones que comprenden compuestos de fórmula general I que modulan la piruvato quinasa. En la presente también se describen métodos para utilizar los compuestos que modulan la piruvato quinasa en el tratamiento de enfermedades.
Patent CR-20150598-A (CR)
Title: Marco de comisura flexible
Inventor: LEVI TAMIR S
IPC: A61F2/24
Filed: 2015-11-02
Abstract: Se proporcionan dispositivos protésicos y marcos para su implantación en un anillo de válvula cardíaca que incluyen un marco anular (que tiene un extremo de entrada y un extremo de salida) y una pluralidad de miembros de marcos axiales que abarca dos filas que se extienden circunferencialmente de las columnas inclinadas.
Patent CR-20160444-A (CR)
Title: Proteínas de fusión uti
Inventor: CHAMBERLAIN AARON
IPC: C07K14/81
Filed: 2015-02-23
Abstract: La presente invención provee proteínas de fusión UTI, secuencias de ADN para producir las mismas, y composiciones farmacéuticas y métodos para usar las mismas.
Patent CR-20190346-A (CR)
Inventor: GEIERSTANGER BERNHARD HUBERT
IPC: C07K16/28
Filed: 2018-02-01
Abstract: Esta solicitud describe anticuerpos anti¿CCR7, sus fragmentos de unión a antígeno y conjugados de fármaco y anticuerpo de dichos anticuerpos o fragmentos de unión a antígeno. La invención también se refiere a métodos para tratar o prevenir el cáncer usando los anticuerpos, los fragmentos de unión a antígeno y los conjugados de fármaco y anticuerpo. En el presente documento también se describen métodos para producir los anticuerpos, los fragmentos de unión a antígeno y los conjugados de fármaco y anticuerpo, y métodos para usar los anticuerpos y los fragmentos de unión a antígeno como reactivos de diagnóstico.This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
Patent CR-20210351-A (CR)
Title: Triple combination therapies for anti-aging
Inventor: LISANTI MICHAEL P
IPC: A61P35/00
Filed: 2019-12-16
Abstract: The present approach effectively eradicates senescent cells and cells carrying the hallmarks associated with aging, through inhibiting mitochondrial biogenesis during induced mitochondrial oxidative stress, without inhibiting normal cells. Embodiments may include a therapeutic agent that inhibits mitochondrial biogenesis and targets the large mitochondrial ribosome, a therapeutic agent that inhibits mitochondrial biogenesis and targets the small mitochondrial ribosome, and a therapeutic agent that behaves as a pro-oxidant or induces mitochondrial oxidative stress. Some embodiments include sub-antimicrobial antibiotic concentrations, thereby minimizing antibiotic resistance concerns.
Patent EC-SP066350-A (EC)
Inventor: GOMBERT HERVE
IPC: C09J103/02
Filed: 2006-02-07
Abstract: The composition (10-40 wt.%): further comprises an alkaline substance (0.3-5 wt.%), borax (0.01-5 wt.%) and all other chemical boron-carrying compound; and is in a dry commercial form, that is free from water components. The cereal starch and/or tubers have a ratio of 30/70-90/10 (preferably 45/55-75/25). The pea starch has an amylose content of 15-60 (preferably 30-52)%. Independent claims are included for: (1) a preparation of corrugated board; and (2) an corrugated board.
Patent EC-SP088986-A (EC)
Title: Formulaciones galénicas de alisquireno e hidroclorotiazida
Inventor: WILLMANN MATTHIAS
IPC: A61K9/20
Filed: 2008-12-17
Abstract: La presente invención se refiere a una forma de dosificación oral sólida, la cual comprende una cantidad terapéuticamente efectiva de alisquireno, o una sal farmacéuticamente aceptable del mismo, una cantidad terapéuticamente efectiva de hidroclorotiazida, y un relleno hidrofílico seleccionado a partir del grupo de un carbohidrato o combinaciones del mismo, por ejemplo azúcares, alcoholes de azúcar, y almidones, o combinaciones de los mismos.
Patent EC-SP972110-A (EC)
Title: Recipiente flexible con multiples compartimentos para drogas, y un metodo para fabricarlo y usarlo
Inventor: BARNEY WARD W
IPC: A61B19/00
Filed: 1997-05-12
Abstract: Un recipiente flexible para combinar el almacenamiento y administración del medicamento y los diluyentes para soluciones IV, el recipiente consiste de una hoja flexible trasera una hoja flexible delantera extendiéndose entre los dos lados del borde periférico y uniéndose separablemente a las hojas frontal y trasera para formar un compartimiento conteniendo el diluyente: un segundo sello pelable extendiéndose entre los dos lados del borde periférico común y uniéndose separablemente a las hojas frontal y trasera para formar allí un compartimiento de salida y un compartimiento conteniendo un medicamento, el cual es intermedio entre el compartimiento de salida y el compartimiento del diluyente: una película transparente de alta-seguridad sellada a la hoja frontal, la película laminada de alta seguridad dimensionada para cubrir todo el compartimiento del medicamento: y una película opaca protectora de alta-seguridad sellada separablemente a la película laminada transparente de alta -seguridad, la película opaca dimensionada para extenderse sobre la película laminada de alta-seguridad y el compartimiento del medicamento.
Patent FI-20012603-A (FI)
Inventor: KLEIMOLA VESA
IPC: G01N33/553
Filed: 2001-12-31
Abstract: The present invention relates to novel methods for the diagnosis of Helicobacter pylori infection. Specifically, the present invention relates to novel non-invasive methods for the detection of the presence or absence of a Helicobacter pylori antigen or a metabolite produced by the bacterium in a biological sample with a biosensor-based measurement. The present invention also related to the use of a biosensor containing specific antibodies against H. pylori or antigen-binding fragments thereof immobilized thereto together with biomolecule-repellent polymers preventing the non-specific binding. The invention also relates to test kits useful in the methods.
Patent FI-20175388-A (FI)
Title: A wireless electronic initiation device, an initiation arrangement and method for initiation
Inventor: YLISAUKKO-OJA ARTO
IPC: F42D1/04
Filed: 2017-05-03
Abstract: A wireless electronic initiation device (100) for a detonator (109) via a shock tube (108) comprises an initiation member (106) for initiation the shock tube (108) and an energy storage (105) for providing initiation energy to said initiation member (106). The initiation device (100) comprises also a wireless communication device (101) with a receiver for receiving an initiation command (206) in a wireless way (107) from an initiation arrangement (200). The initiation device (100) comprises also a controller (102), which is configured to determine said received initiation command (206) and based on said received initiation command configured to activate said initiation member (106) to ignite the detonator initiator (108) by the energy fed from the energy storage (105).
Patent FR-1415553-A (FR)
Inventor: LAMPARTER HELMUT
IPC: G10L25/00
Filed: 1964-05-26
Granted: 1965-10-29
Abstract: 1,041,948. Frequency digitizers. INTERNATIONAL BUSINESS MACHINES CORPORATION. May 26, 1965 [May 26, 1964], No. 22348/65. Heading G4H. The excitation function is produced from vocal signals by apparatus which includes means for eliminating the effects of spurious zero-crossings caused by harmonics. The signals are passed through a low-pass filter 2, Fig. 6 (not shown), to a zero-crossing detector 3. Counter 5 is continuously advanced by clock pulses and is reset by detector 3, the output of which also opens gate 6 to pass the contents of the counter to register 11. If no spurious zero crossings have occurred adder/subtractor 9 and decision circuit 10 determine that the sum of the contents of registers 11 and 12 is significantly greater than the contents of register 13 and a shift signal is produced to transfer the contents of each register to the next, register 13 feeding mean value circuit 8. If a spurious zero-crossing occurs, the sum of the contents of registers 11 and 12 is approximately the same as the contents of register 13, no shift signal is produced and the contents of 12 are replaced by the sum from 11 and 12, the next digitized value subsequently being substituted in 11. Circuit 8 includes a shift register 14 containing the last ten digitized values, a register 16 containing the sum of the last ten values (s), adder 15 deriving the new sum (s+tn-tn-10), and a divider 17 dividing the sum by 10 to obtain the mean value.
Patent FR-1551699-A (FR)
IPC: E05D15/52
Filed: 1968-01-22
Granted: 1968-12-27
Abstract: 1,205,498. Releasable hinge; multiple fastenings. A. MARGUELISCH. 23 Jan., 1968 [28 Jan., 1967], No. 3475/.68. Headings E2A and E2F. A releasable hinge, permitting hinging in either one of two mutually perpendicular directions, comprises a pin 5, which may have a ball head 4, retained in a socket 6 by a rotatable plate 9.. When the plate is rotated so that a recess 10 is above the socket, the ball escapes from the socket thus breaking the hinge connection. Four such hinges may be used to pivot a window 1, 2, along any of its sides. The rotatable plates 9 are operated simultaneously by a handle 14, a pinion 13 and a chain 12, and are arranged so that two adjacent plates have their recesses 10 above the socket 6 thus allowing the balls to escape, while the other two plates maintain their hinge connection. A window may also be pivoted using 2 such devices and a conventional universal joint.
Patent FR-1572923-A (FR)
IPC: B65D5/49
Filed: 1968-07-24
Granted: 1969-06-27
Abstract: 1,185,807. Partitions for boxes. GUSTAV STABERNACK G.m.b.H. 26 July, 1968 [29 July, 1967; 2 April, 1968], No. 35933/68. Heading B8P. A box partitioning blank has panels 15 ... 24, Fig. 2, separated by fold-lines ... 14, with incisions 15a, 17a, 19a, 2]a along the top edges of the panels 15, &c., the incisions being engaged when the partition is erected by notches 24a on the bottom edge of an interlock panel 24, the cut-lines 12a, 13a partly separating the panels 21, 22, 23 and the panel 22 having a central fold-line 22a to allow turning-over of the interlock panel 24 relatively to the rest of the blank during erection. The partition is formed by first folding the panels 15... 21, Fig. 3, perpendicular to each other. The interlock panel 24, the panel 23 and the adjacent upper panel half 22 are then folded at right-angles to each other, and the panel 22 folded along the line 22a, so that the interlock panel is horizontal. Finally, the panel 22 is straightened, and the notches 24a in the interlock panel 24 inserted into the incisions 15a, &c. of the panels 15, &c., Fig. 4. The erected partition shown fits inside a rectangular carton, Fig. 5 (not shown), having simple top and bottom flaps (2b-5b). As shown, the partition blank provides ten compartments. Alternatively, blanks having fewer or more panels 15, &c. may be erected to provide from four to thirty compartments, Fig. 6 (not shown).
Patent FR-1601065-A (FR)
Title: Resolution of dl-6-phenyl-2 3 5 6-tetrahydroimidazo 2 1-b -thiazole
IPC: C07D513/04
Filed: 1967-06-01
Granted: 1970-08-10
Abstract: Compounds 1(-)-6-phenyl-2,3,5,6-tetrahydroimidazo (2,1-b)-thiazole and its d-10-camphorsulphonate, and hydrogen halide salts and d(+)6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)-thiazole and its d-10-camphorsulphonate, and hydrogen halide salts. The laevo-isomer has been found to have anthelmintic activity, whereas the dextro-isomer is devoid of activity but is toxic. The laevo-isomer has a much greater margin of safety in animals than does the known racemic dl-compound. The compound is effective against e.g. Nematospiroides dubius, and Trichostrongylus colubriformis.
Patent FR-1604972-A (FR)
Title: Polybutene asphalt mixtures
IPC: C08L23/20
Filed: 1967-11-02
Granted: 1972-06-26
Abstract: Polybutene-1/asphalt mixture contng. 5 to 95% wt. polybutene-1 and 95 to 5% wt. asphalt to which are added up to 50% wt., pref. 15-30 % wt. of a charge such as silica, CaCO3, talc, mica, Ca silicate, BaSO4, BaCO3, MgCO3, alumina etc. The polybutene-1 is a homopolymer contng. pref. 60-95% isotatic structure. The mixtures of this invention are used for pipeline protectives, and sealing agents and have good flexibility, tensile strength, oil resistance etc. Polybutene-1 having a fusion index of 6.9 and 58% insolubles in ether and an asphalt having fusion point of 62 deg. - 73 deg.C. are mixed in a 1 : 1 ratio to give a homogeneous film which was pressed at 110 deg.C. to obtain a plaque 0.125 mm. thick. The tensile strength of this plaque was found to be 234 kg./cm2.
Patent FR-1604991-A (FR)
Title: Aminodiaryl-indolylmethane dyes esp for - acrylic fibres
IPC: C09B11/26
Filed: 1968-12-31
Granted: 1972-06-26
Abstract: The dyes, free from HSO3 and COOH gps., have formula:- (in which A and A1 and A1 = aryl gps., at least one being of the naphthalene series, R1 and R4 = H, (cyclo)alkyl, aralkyl or aryl gp., R2 = H, (cyclo)alkyl or aralkyl gp. or R1 and R2, with the N atom, = heterocyclic ring, R3 = H, alkyl, aryl, carboxylic acid ester, optionally N-substd. carboxamide or alkoxy gp., and X- = anionic radical), and may contain further substituents. They are prepared by condensing a benzoyl- or naphthoylarylamine of formula:-.
Patent GB-1051803-A (GB)
IPC: F16L25/08
Abstract: 1,051,803. Pipe coupling; bolting. LUSTRAPHONE Ltd. Feb. 12, 1965 [Feb. 21, 1964]. No. 7448/64. Headings F2G and F2H. [Also in Division E2] A pipe coupling comprises one member 1 having a tapped hole 3 containing a screw 5, a second member fitting over the first and containing an aperture formed such as to permit the entry of part of the head of the screw but preventing the head from passing through, the members being connected together by unscrewing the screw so that the head of the screw is engaged in the aperture. Preferably three equally spaced screws and apertures are provided and the tapped hole is counterbored to receive the head of the screw.
Patent GB-1051812-A (GB)
IPC: D21D1/30
Abstract: 1,051,812. Pulp refiners. D. G. PASTOR, May 14, 1965 [May 23, 1964], No. 20452/65. Heading B2A. A twin-action depulper for fibrising paper cuttings or untreated pulp has a shaft 3 with a plate 7 secured thereto, and toothed rings 8 fixed to the plate and co-acting with fixed rings 9. The depulper includes a water cooling chamber 6 for a water seal 5, a lubricating chamber 11 for the bearings of the shaft, and a cleaning trap 2.
Patent GB-1225940-A (GB)
IPC: B25C1/04
Filed: 1969-10-01
Abstract: 1,225,940. Fastener driving device. D. HAUBOLD, [trading as DIETER HAUBOLD INDUSTRIELLE NAGELGERATE]. 1 Oct., 1969 [4 Oct., 1968], No. 48276/69. Heading B4C. A pneumatically operable device for driving fasteners into a workpiece comprises a piston 5 reciprocable in a cylinder 4, and magnetic means, e.g. an annular permanent magnet, 16 for holding the piston in an initial position. A cover 14 releasably connected to the body of the device by a pin 19 has depending lugs 17 which engage an annular steel plate 13. The plate retains the magnet in position. In use depression of the trigger 11 actuates control valve 10 to allow compressed air to pass from reservoir 2 to the upper end of cylinder 4. The air pressure overcomes the magnetic attraction and the piston performs a working stroke. At the end of the working stroke air passes into chamber 21 and when the trigger is released the air in the chamber acts on the underside of the piston to return it to its initial position. The volume above the piston is open to atmosphere via the control valve and vent duct 23. Alternatively, the magnetic means may be a plurality of bar type magnets or the annular magnet may be segmented.
Patent GB-1229950-A (GB)
IPC: A47B17/00
Filed: 1968-12-11
Abstract: 1,229,950. Desks. CLAUDE R. OGDEN & CO. PTY. Ltd. 11 Dec., 1968 [22 Dec., 1967], No. 58999/68. Heading A4H. A desk has a rectangular cross-section metal tubing main frame comprising legs 1, 2 connected by top and secondary rails 3, 5, 7, and 4, 6, 8; the desk top comprises longitudinal and transverse rails 9, 10, 14 and 11, 12, 13, and a panel 15. Panel 15 is fixed to the desk top rails, and the desk top is fixed to the main frame rails 3, 5, 7 by screws 16. A drawer unit 17 is mounted between rails 12, 13 and located on lugs on brackets 18. It is secured by clamping screws 19 in rails 13 and by screws 20a passing through plates 20 on rails 6, 8. A back panel 21 is mounted in channel members 22, 23 fixed to drawer unit 17 and the back leg 1, and is secured to rails 7, 8 by screws 24. An end panel 25 is secured to legs 1 by screws 26 and angle members 27. Panel 15 may comprise plywood secured to a base compressed wood pulp. Panels 21, 25 may each comprise two sheets of plywood. The desk may have a drawer unit 17 at each end secured to respective desk top rails 13; channel 23 is fixed to the other drawer unit 17 and end panel 25 is omitted.
Patent GB-1231463-A (GB)
IPC: F21V19/00
Filed: 1968-05-08
Abstract: 1,231,463. Vehicle headlamps. SOC. ANON. POUR L'EQUIPMENT ELECTRIQUE DES VEHICULES S.E.V.-MARCHAL. 8 May, 1968 [8 May, 1967], No. 21797/68. Heading F4R. A headlamp comprises a reflector 1 having an opening through which the bulb 4 can be inserted from the rear, a rearwardly extending tubular member 10 secured to the collar 2 surrounding the opening, and a resilient locking means which extends around the tubular member and includes projections 16 which are biased inwardly towards the axis of the tubular member, the projections including, or bearing against, surfaces which are inclined to this axis so that a force is exerted on the bulb-holder 3 urging it towards the reflector. The bulb-holder can be withdrawn by pulling it rearwardly to cause outward deflection of the projections. In the embodiment shown the projections are conical studs which are carried by an open resilient ring 18 and bear directly against the rim of the bulb holder, whilst in a second embodiment (Figs. 5 and 6, not shown) the studs bear against an intermediate member (22) which is mounted on the base (5) of the bulb by means of a split skirt (23) and abuts against the bulb-holder. In a third embodiment (Figs. 7 and 8, not shown) the locking means consists of a resilient wire (46) having three inwardly directed elbows (46a) which engage inclined surfaces (45) on the intermediate member (37), and in a fourth embodiment (Figs. 9-11, not shown) the intermediate member bears on the bulb-holder flange (48) and is held in position by a spring (49). In a fifth embodiment (Figs. 12 and 13, not shown) the intermediate member (57) has a skirt (56) which projects out of the tubular member (10), and the wire (46) has only two elbows (46a).
Patent GB-1232219-A (GB)
IPC: B30B15/28
Filed: 1968-10-01
Abstract: 1,232,219. Safety devices. L. SCHULER G.m.b.H. 1 Oct., 1968 [9 May, 1968], No. 46522/68. Heading F2J. A safety device ensuring stopping of a press ram in the event of a failure of the normal control system, the press being operated by a pneumatically controlled clutch and brake, comprises a valve 6 which, in the event of failure of the ram to stop in its top dead centre poistion, is actuated by a cam 44 on the main press shaft. Actuation of the valve 6 closes a passage between a port 3 leading to the clutch and brake and a port 2 connected to the compressed air supply by way of a main control valve (not shown) and opens the port 3 to a vent port 4 so that the clutch disengages and the brake is applied by spring pressure. The cam 44 cooperates with a follower roller 30 carried by a bell crank lever 29 pivoted to a lever 31 which is pivoted at 32 to the press frame. The lever 31 engages an end of the valve 6 and is engageable by a surface 33 of the lever 29. The lever 29 is pivotally connected to a single-acting piston 41 supplied with compressed air under the control of solenoid valve 43. On depressing a start button for single stroke operation of the press, the valve 43 is actuated so that compressed air acts on the piston 41 and shifts it to the right, thereby rocking the lever 29 and removing the roller 30 from the path of the cam 44 and also actuating a switch 26 which actuates contacts causing the main control valve to operate and thus supply pressure to start the press. Rotation of the cam 44 operates a switch 46 controlling the valve 43 so that the piston 41 is returned to its initial position by spring 23 and the roller 30 is brought into the path of the cam 44. At the end of a cycle, if the ram fails to stop in its top dead centre position (illustrated) the roller 30 will be displaced by a swell 45 on further rotation of the cam and levers 29, 31 will be rocked anti-clockwise and actuate the valve 6 to vent the clutch and brake so that the clutch disengages and the brake is applied. A pawl 34 has a step 36 holding the lever 31 in its displaced position and the pawl has to be reset manually before the press can be operated again. Actuation of the valve 6 also actuates a switch 16 which switches off the entire current supply to the press.
Patent GB-1232625-A (GB)
IPC: G06M3/02
Filed: 1968-05-10
Abstract: 1,232,625. Counting-apparatus. A. O. SMITH CORP. 10 May, 1968 [24 May, 1967], No. 22367/68. Heading G4D. The numeral wheels of a pre-settable counter are made in two parts 5, 26 normally held with ratchet teeth 29, 30 engaging by a pair of springs 33, 34. The two parts can be pulled apart manually and turned to provide a fine adjustment in the direction in which the one set of teeth ride over the other. As applied to a fuel dispensing device the gallonage is set up as described in Specification tion 22366/68 by operating rods 4. The meter 13 drives the counter wheels subtractively. When all the higher denomination wheels reach zero a comb 28 releases a trigger finger 24 associated with the units wheel which rocks a crank 20 for a brief period. The crank 20 releases a catch 21 and therefore a pawl 9 to allow a spring-pressed ring 7 to make one step counter-clockwise, so half shutting the flowvalve. The trigger finger 24 is restored by a cam 27 on the units wheel until zero is attained when the pawl 9 is released again so that the ring 7 makes a further step to stop the flow.
Patent GB-1232642-A (GB)
IPC: B01D24/00
Filed: 1968-06-07
Abstract: 1,232,642. Converting cartridge filter to bed filter. ECODYNE CORP. 7 June, 1968 [13 June, 1967], No. 27247/68. Heading B1D. Cartridge-type filter (Fig. 1), comprising filter cartridges 30 is converted to bed-type filter (Fig. 2) by removing cartridges 30, screwing strainers 70 or caps 90 on to seatings 40 and extending inlet pipe 14 by means of extension 56 to a point above the top of the filter bed 68. As a result, instead of influent material entering by pipe 14, being deflected by plate 52 (Fig. 1), and passing out and through filter cartridges 30 to effluent zone 24 before leaving by pipe 16, the influent material passes by pipe 56 (Fig. 2), to a point above bed 68 before being deflected by plate 64 downwards through the bed, e.g. of ion exchange resin or crushed anthracite, and thence through strainers 10 to effluent zone 24 before leaving by pipe 16. Embodiments of strainers 70 are illustrated in Figs. 3-5 (not shown).