baber/WOPTO huggingface dataset:
Patent JP-2021503300-A (JP)
Title: 操作エクソソームの組成物及び内腔エクソソームペイロードの搭載方法
IPC: C07K16/00
Filed: 2018-11-16
Abstract: 本発明は、エクソソームの内腔で富化されることが新たに確認されたタンパク質を使用して、治療エクソソームを調製する方法に関する。具体的には、本発明は、エクソソーム中に、治療ペプチドまたはタンパク質を局在化させる方法を提供する。本方法は、高濃度のエクソソームタンパク質、エクソソームタンパク質の改変体もしくは断片、またはエクソソームタンパク質及び治療もしくはカーゴタンパク質の融合タンパク質のうちの１つ以上を含む、内腔操作エクソソームの生成を含む。【選択図】なし
Patent JP-2021503955-A (JP)
Title: トレハロースホスホリラーゼバリアントを使用するトレハロースの生産方法
IPC: C12P19/12
Filed: 2018-11-28
Abstract: 本発明は、（i）糖類原材料および少なくとも1つのリン供給源からのアルファ-D-グルコース1-リン酸中間体の生成を触媒する能力を有する、少なくとも1つのアルファ-ホスホリラーゼ、（ii）アルファ-D-グルコース1-リン酸中間体およびグルコース基質からのトレハロースの生産を触媒する能力を有し、少なくとも1つのアミノ酸位置において野生型トレハロースホスホリラーゼのアミノ酸配列とは異なるアミノ酸配列を持つトレハロースホスホリラーゼバリアントである、少なくとも1つのトレハロースホスホリラーゼ、（iii）アルファ-ホスホリラーゼの触媒作用によってアルファ-D-グルコース1-リン酸中間体と副産物とを生成する、少なくとも1つの糖類原材料、ならびに（iv）リン酸およびその無機塩からなる群より選択される少なくとも1つのリン供給源を任意の順序で混合し反応させる工程を含む、トレハロースの生産方法に関する。
Patent JP-2021508586-A (JP)
Title: Ｏｓｓインターベンショナルデバイスのアニメーション位置表示
IPC: A61B34/20
Filed: 2018-12-29
Abstract: １つ以上の光学形状センサ及び１つ以上のインターベンショナルツールの統合を含む、インターベンショナルデバイス４０のためのＯＳＳアニメーション表示システムである。ＯＳＳアニメーション表示システムは、モニタ１２１と、ＯＳＳインターベンショナルデバイス４０と物体５０との間の空間位置関係のアニメーションのモニタ１２１上のリアルタイム表示を制御するための表示コントローラ１１０とを利用する。表示コントローラ１１０は、１つ以上の光学形状センサの形状からＯＳＳインターベンショナルデバイス４０と物体５０との間の空間位置関係のアニメーションを導出する。
Patent JP-2021519851-A (JP)
Title: ポリイミド共重合体、ポリイミド共重合体の製造方法、これを利用した感光性樹脂組成物、感光性樹脂フィルムおよび光学装置
IPC: C08G73/10
Filed: 2020-03-11
Abstract: 本発明は、エポキシ化合物から合成された単量体に由来する特定構造の繰り返し単位を含むポリイミド共重合体、ポリイミド共重合体の製造方法、これを含む感光性樹脂組成物、感光性樹脂フィルムおよび光学装置に関する。
Patent JP-2021517883-A (JP)
Title: 五塩化タングステンコンディショニング及び結晶相マニピュレーション
IPC: C01G41/00
Filed: 2019-04-30
Abstract: 特有の結晶相を形成するための五塩化タングステンのコンディショニングが開示される。この特有の結晶相は、蒸着及びエッチングプロセスの間中長時間にわたって安定した蒸気圧を可能にする。【選択図】図３
Patent JP-2021522920-A (JP)
Title: ノズル及びカートリッジ組立体
IPC: B65D83/00
Filed: 2019-05-27
Abstract: スプレー装置のための組立体であって、加圧される液体を含むカートリッジ（３５；３５′；３５′′′）と、加圧された前記液体からエアゾールを生成するように構成されたマイクロノズル（５０）とを備え、該マイクロノズル（５０）は、カートリッジ（３５；３５′；３５′′′）に永久的に取り付けられている。
Patent JP-2021524428-A (JP)
Title: ガラス板を成形する方法およびそれに利用される曲げ工具
IPC: C03B23/03
Filed: 2019-05-16
Abstract: ガラスシートを成形する方法を提供する。第１のガラスシートは、第１の曲げ工具の第１の位置に配置され、第１のシートの縁部が第１のシートを第１の曲げ工具に対する第２の位置に移動させるように接触した後に成形され、および、第２のガラスシートはまた、第１の曲げ工具の第１の位置に配置され、第２のシートの縁部が第２のシートを第１の曲げ工具に対する第２の位置に移動させるように接触した後に成形される。第１のシートの第１の縁部の第２の位置は、第１の曲げ工具に対する第２のガラスシートの第１の縁部の第２の位置とは異なる。第１および第２のガラスシートは、異なるサイズのものであり得、それぞれが成形された後に共に積層され得る。
Patent JP-2022516390-A (JP)
Title: ５ｇミリメートル波システムのためのビーム追跡
IPC: H04B7/08
Filed: 2019-12-11
Abstract: ミリ波ビーム追跡およびビーム掃引の諸側面が記載される。たとえば、装置は、諸サブアレイを含むアンテナ・アレイと、アンテナ・サブアレイにおいてビームフォーミング、ビーム追跡、およびそれらの管理を実行するように構成された処理回路とを含むことができる。処理回路は、さらに、ビームフォーミング機能の実行に応答して受信された受信信号の到達角を決定し、到達角に応じて当該装置の移相器を調整するように構成されることができる。他の装置、システムおよび方法が記載される。
Patent JP-2021526763-A (JP)
Title: ネットワークを管理するための方法及びその装置
IPC: H04L45/02
Filed: 2019-07-09
Abstract: コンピュータネットワークを管理する方法が提供され、方法は、コンピュータネットワークのノードと、コンピュータネットワークの２つのノードの間の隣接関係にそれぞれ対応するエッジとを表す経路木の第１の深さレベルに対応する１つ以上のネットワークノードの集合に属するコンピュータネットワークの少なくとも１つのネットワークノードにおいてデータ収集を実行することを含み、データ収集は、コンピュータネットワークの経路木内の少なくとも１つのネットワークノードの親ノードから第１のデータ収集構成データを受信することであって、第１のデータ収集構成データは、経路木の第１の深さレベルに対応するノードにおいてデータを収集するために必要とされるリソースの推定量を含むことと、コンピュータネットワークの少なくとも１つのネットワークノードの経路木内の少なくとも１つの子ノードからデータを収集する第２のデータ収集構成データを、第１のデータ収集構成データに基づいて生成することであって、第２のデータ収集構成データは、少なくとも１つの子ノードのそれぞれからデータを収集するスケジューリングデータを含むことと、第２のデータ収集構成データに従って少なくとも１つの子ノードのそれぞれからデータを収集することとを含む。
Patent JP-2021528242-A (JP)
Title: 噴出ディスペンサの位置的制御システム及び方法
IPC: B05C11/10
Filed: 2019-06-25
Abstract: 物質をアプリケータから噴出させるアプリケータの可動部品の動きを制御するシステム及び方法が開示される。本方法は、ニードルに作動的に連結された圧電装置を、この圧電に電圧波形を提供することによって作動させてニードルが第１の定量吐出又は小出し操作において位置的経路に沿って並進するようにするステップを含む。本方法は、圧電装置に印加されるべき所要の電圧波形を決定して第２の小出し操作を実行するステップと、圧電装置に印加されるべき電圧波形を調節して所要の位置的プロフィールに合わせるステップとをさらに含む。
Patent JP-2022106008-A (JP)
Title: Land leech repellent tool
Inventor: NAKANO TAKAO
IPC: A01N25/00
Filed: 2021-01-06
Abstract: To provide a land leech repellent tool which is easily manufactured with a simple structure, is easy to be handled at the time of being worn, and has a repellent effect for a long period of time.SOLUTION: A land leech repellent tool is formed by making a sheet made of any one of: a woven fabric obtained by using a copper yarn having copper on its outer surface as a portion of at least one of a warp yarn and a weft yarn; a knitted fabric obtained by using the copper yarn as a portion; and a copper fiber nonwoven fabric obtained by papermaking copper fibers to form a web and pressure-sintering it, into a belt shape or an annular shape.SELECTED DRAWING: Figure 2
Patent JP-2022106113-A (JP)
Title: Boron nitride powder, heat-conductive resin composition, heat radiation sheet, and electronic component structure
Inventor: WADA KOSUKE
IPC: C08K3/38
Filed: 2021-01-06
Abstract: To provide a boron nitride powder for obtaining a heat radiation sheet excellent in thermal conductivity, a heat radiation sheet excellent in thermal conductivity, and a method for manufacturing the heat radiation sheet excellent in thermal conductivity.SOLUTION: A boron nitride powder contains at least aggregated boron nitride particles obtained by aggregating hexagonal boron nitride primary particles. The boron nitride powder contains a vinyl group-containing silane coupling agent, and has a ratio ((Ia/Ib)×100) of intensity Ia of an infrared absorption peak (3076 cm-1±2 cm-1) derived from a vinyl group to intensity Ib of an infrared absorption peak (1377 cm-1±2 cm-1) derived from boron nitride in the range of 0.1 to 10.SELECTED DRAWING: Figure 1
Patent JP-2022106485-A (JP)
Title: Program, information processor, game starting timing display method
Inventor: SHINOZUKA ISAO
IPC: A63F13/795
Filed: 2021-01-07
Abstract: To provide a new setup for allowing a first player who recruits participation in a game and a second player who desires to participate in the game in response to the recruitment to share information for showing timing when the game is started.SOLUTION: A program is provided, which allows an information processor in which a first player recruits participation in a game, and the first player and at least one second player who gather in response to the recruitment play the same game to function as setting reception means for receiving a setting of information for showing timing when the first player starts playing the game, and as screen control means for allowing the first player to recruit participation in the game, and for displaying information for showing timing when the game that receives a setting from the first player is started on a screen for receiving the desire to participate in the game from the second player.SELECTED DRAWING: Figure 8
Patent JP-2022111562-A (JP)
Title: Position measurement device and position measurement system
Inventor: KAGAMI SOTA
IPC: G01S5/14
Filed: 2021-01-20
Abstract: To provide a position measurement device, etc. which enable highly accurate position measurement on the basis of at least three signals.SOLUTION: A position measurement device 12 to be mounted on a device under control is provided. The position measurement device 12 comprises: a first signal reception unit 121 configured to receive first signals, each containing position information associated with a given position and data with transmission time associated therewith; an atomic clock 122; a position computation unit 123 configured to compute a position of the device under control using data contained in at least three first signals and the time measured by the atomic clock; and an output unit 125 configured to output a third signal containing the computed position information on the position of the device under control.SELECTED DRAWING: Figure 3
Patent JP-2022116853-A (JP)
Title: Vehicular air conditioner
Inventor: ENDO HIROKAZU
IPC: B60H1/00
Filed: 2021-01-29
Abstract: To close a passage in a reliable manner and maintain a desired opening of an opening of the passage even if an inclination occurs in a slide door within an air-conditioning case at a vehicular air conditioner.SOLUTION: In an air-conditioning case 14 forming a vehicular air conditioner 10, an air mix door 42 is movably provided along a guide groove 38 provided at its inner wall. Further, the air-conditioning case 14 has first and second seal walls 60, 66 which an end as seen in a slide direction of the air mix door 42 contacts and seals. In the air mix door 42, driving force from an actuator 58 is transmitted only to one end 42a side as seen in a width direction. Clearances between the first and second seal walls 60, 66 and the air mix door 42 are set so that the side of the one end 42a as seen in the width direction is longer than the side of the other end 42b as seen in the width direction of the air mix door 42.SELECTED DRAWING: Figure 2
Patent JP-2022119040-A (JP)
Title: Road area identification device, road area identification method, and program
Inventor: OGAKI SHIORI
IPC: G09B29/00
Filed: 2021-02-03
Abstract: To identify a road area precisely.SOLUTION: A road area identification device includes: a first acquisition unit for acquiring a numerical value altitude model showing altitude of the earth's surface of a predetermined geographical area and a numerical value surface layer model showing altitude of a feature surface of a geographical area; a second acquisition unit for acquiring ridge/valley line data showing a ridge line and a valley line of a geographical area; a calculation unit for calculating an inclination distribution and a feature height distribution of a geographical area on the basis of a numerical value altitude model and numerical value surface layer model; an extraction unit for extracting a road candidate area from a geographical area on the basis of an inclination distribution and a height distribution; an identification unit for identifying areas excluding areas corresponding to a ridge line and a valley line shown in ridge/valley line data from a road candidate area as road areas; and an output unit for outputting information regarding a road area.SELECTED DRAWING: Figure 6
Patent JP-2022120507-A (JP)
Title: Copolymer and method for producing the same, and film
Inventor: IMOTO SHINYA
IPC: C08F220/12
Filed: 2021-02-05
Abstract: To provide a method for producing a copolymer containing a constitutional unit derived from α-methylene lactone, and capable of improving the transparency of the produced copolymer.SOLUTION: The present invention discloses a method for producing a copolymer containing a constitutional unit derived from alkylmethacrylate, having a constitutional unit derived from α-methylene lactone and a C1-6 alkyl group. The production method includes: a first step of preparing a liquid mixture containing α-methylene lactone, alkylmethacrylate, and solvent; and a second step of heating the liquid mixture and instilling α-methylene lactone into the heated liquid mixture. Relative to the total mass of the α-methylene lactone contained in the liquid mixture in the first step and the α-methylene lactone instilled into the liquid mixture in the second step, the mass ratio of the α-methylene lactone instilled into the liquid mixture in the second step is 10-80 mass%.SELECTED DRAWING: None
Patent JP-2022121961-A (JP)
Title: Protection cover device and positioning structure of external fitment member of protection cover
Inventor: NAKAMURA ATSUSHI
IPC: F16L57/00
Filed: 2021-02-09
Abstract: To prevent an external fitment member such as a cock cover arranged at an end part of a protection cover in an external fitment state from moving to the protection cover, or from getting out of the protection cover.SOLUTION: One of a plurality of block maintenance tools D for maintaining a block state of a divided opening 1 of a long-length cylindrical protection cover C0 for accommodating a fluid pipe P therein is attached to one end part of the protection cover C0 in an axial direction, and a positioning protrusion 22a abutting on an end face of the block maintenance tool D at a depth side is formed inside divided bodies E1a, E1b of a two-divided structure cock cover E1, a positioning ring part 35 abutting on a release end face C0a of the protection cover C0 is arranged inside a sideway opening 36 of one divided body E1b having a sideway opening 34, and the cock cover E1 does not move to both sides in the axial direction with respect to the protection cover C0.SELECTED DRAWING: Figure 11
Patent JP-2022122167-A (JP)
Title: Stretchable sheet for absorbent article and method for manufacturing the same
Inventor: NIITSU TAICHI
IPC: A61F13/15
Filed: 2021-02-09
Abstract: To provide a stretchable sheet for an absorbent article having an excellent air permeability, blocking resistance and excellent storage stability, and a method for manufacturing the same.SOLUTION: A method for manufacturing a stretchable sheet for an absorbent article of the present invention comprises: a composite nonwoven fabric manufacturing step in which a plurality of melted or softened elastic filaments 3 spun from a plurality of spinning nozzles are brought into contact with one surface of an original nonwoven fabric 4 before solidification of the elastic filaments 3 to obtain a composite nonwoven fabric 5 in which the elastic filaments 3 are fused to one surface of the original nonwoven fabric 4 while being exposed; a surface roughness imparting step of forming unevenness in a non-contact portion itself with the original nonwoven fabric 4 on the surface of the elastic filament 3; and a stretching step of the composite nonwoven fabric 5.SELECTED DRAWING: Figure 5
Patent JP-2022122773-A (JP)
Title: Evaluation device and evaluation method
Inventor: HORI RYUJI
IPC: G06F11/36
Filed: 2021-02-10
Abstract: To provide an evaluation device and an evaluation method that can efficiently perform a regression test.SOLUTION: An evaluation device according to an embodiment comprises: a control unit; and a storage unit. The control unit is configured to output input data on a simulation to a simulation device causing a simulation of control to implement between an Electronic Control Unit and a simulation device simulating a control object of the Electronic Control Unit; and collect the output data serving as a result of the simulation. The storge unit is configured to store the input data and a data set serving a set of output data. The control unit is configured to, when changing a program of at least one of the Electronic Control Unit and the simulation device, implement a simulation using the input data stored in the storage unit; and implement a regression test comparing the data sets before and after changing the program thereof.SELECTED DRAWING: Figure 2
Patent JP-2022123356-A (JP)
Title: power storage device
Inventor: YONEZAWA SHO
IPC: H01G11/78
Filed: 2021-02-12
Abstract: To provide a power storage device which can prevent damage to power storage elements.SOLUTION: A power storage device 10 comprises: a plurality of power storage elements 200 each of which has a container body 220, and a lid 230 for closing the container body 220 and welded to the container body 220; a pair of end plates 400 which sandwich, in a predetermined direction, the plurality of power storage elements 200 aligned in the predetermined direction; and coupling parts which are provided to extend along the predetermined direction and are coupled to the pair of end plates. In at least one of the pair of end plates, a portion which overlaps a welding part 260 between the container body 220 and the lid 230 when viewed in the predetermined direction (an X-axis direction) serves as a first protrusion 438 protruding to the side opposite to the power storage elements 200.SELECTED DRAWING: Figure 9
Patent JP-2022131808-A (JP)
Title: Adhesive tape and bonded product
Inventor: KIDO TATSUYA
IPC: B32B27/00
Filed: 2021-02-26
Abstract: To provide an adhesive tape that has better followability to a curve or a curved surface shape than a conventional one, enhances adhesion working efficiency, reduces material waste loss, and enhances its appearance quality; and a bonded product.SOLUTION: The adhesive tape of the present invention includes at least an adhesion layer formed from a component A, and a release layer that is formed from a component B and covers one surface of the adhesion layer. A stress at the time when extensibility of the release layer is 50% is in a range of 1-25 MPa, a stress at the time when extensibility of the adhesion layer is 50% is in a range of 1-6 MPa, and a peel strength between the adhesion layer and the release layer is in a range of 0.05 N/cm to 0.5 N/cm.SELECTED DRAWING: Figure 1
Patent JP-2021099361-A (JP)
Title: System, method, and device for utilizing radar with smart device
Inventor: BRIAN SILVERSTEIN
IPC: G08B21/02
Filed: 2021-03-03
Abstract: To provide a method, a device, and a system for utilizing radar in a smart device.SOLUTION: An electronic device includes: circuit boards; a housing; a communication module coupled to the circuit board, including one or more antennas and configured to communicate with a remote device; and a radar module coupled to the circuit boards, configured to generate radar data for home environment. The radar module includes: a low power radar transmitter; and a radar receiver, The radar module includes one or more processors mounted on one of the circuit boards. The processors are configured to: manage operation of the communication module and the radar module; determine a location and/or movement of detected objects in the home environment; and detect anomalies associated with the detected objects. The electronic device further includes a power source coupled to the processors, the communication module, and the radar module.SELECTED DRAWING: Figure 1
Patent JP-2022139466-A (JP)
Title: Magnetic sensor and manufacturing method therefor
Inventor: KUROKI KOJI
IPC: H01L43/08
Filed: 2021-03-12
Abstract: To reform a magnetic sensor with a ferromagnetic film having multilayered structure.SOLUTION: A sensor chip 10 of a magnetic sensor 1 comprises: a magneto-sensitive element R1; ferromagnetic films M1, M2 which are provided on an insulating film 32 covering the magneto-sensitive element R1 and form a magnetic gap G1 overlapping the magneto-sensitive element R1: and a passivation film 33 which is provided on the ferromagnetic films M1, M2 in such a manner that the magnetic gap G1 is embedded. Each of the ferromagnetic films M1, M2 includes a lower magnetic film 41 and an upper magnetic film 42, the width of the magnetic gap G1 has a width W2 between the upper magnetic films 42 and a width W1 between the lower magnetic films 41, wherein the width W2 is larger than the width W1, and the lower magnetic film 41 is composed of material having a magnetic permeability higher than that of the material of the upper magnetic films 42. Thus, the magnetic sensor 1 has high detection sensitivity since a magnetic flux is efficiently applied to the magneto-sensitive element.SELECTED DRAWING: Figure 4
Patent JP-2022140876-A (JP)
Title: refrigerator
Inventor: ABE KO
IPC: F25B1/00
Filed: 2021-03-15
Abstract: To provide a refrigerator that can efficiently perform heat dissipation of a condenser and cooling of a compressor.SOLUTION: In a refrigerator according to the present disclosure, a compressor and a condenser constituting a refrigeration cycle, and a fan are arranged in a machine room of the refrigerator. The condenser comprises a flattened tube inside which a plurality of refrigerant flow passages are formed, an inlet side header connected to the compressor, and through which a refrigerant flows into the flattened tube, an outlet side header through which the refrigerant flows out to the outside of the flattened tube, and a fin provided between the flattened tube formed so as to be folded in a meandering shape between the inlet side header and the outlet side header. The fan is arranged between the compressor and the condenser. The inlet side header and the outlet side header are formed so as to protrude in a direction opposite to the compressor.SELECTED DRAWING: Figure 1
Patent JP-2022141389-A (JP)
Title: wireless communication system
Inventor: KOJIMA FUMIHIDE
IPC: H04W84/10
Filed: 2021-03-15
Abstract: To provide a wireless communication system capable of achieving in a short time with low power consumption, rec-connection of a once-disconnected mobile terminal to a wireless communication network.SOLUTION: In a wireless communication system 1 having nodes 3-1, 3-2 for establishing a wireless communication link with an approaching mobile terminal 4; a node for transmitting a beacon before starting wireless communication; and a mobile terminal for establishing a wireless communication link with an originating node of the received beacon. The nodes make frequencies of beacon transmission different from each other chronologically in accordance with chronological locations of the mobile terminals brought closer to or separated from each other.SELECTED DRAWING: Figure 1
Patent JP-2022143018-A (JP)
Title: Temporary fastening tool
Inventor: KIRA KAZUHIKO
IPC: B25B23/12
Filed: 2021-03-17
Abstract: To provide a temporary fastening tool which can temporarily fasten a screwing member in which a hole or the like is formed with high workability.SOLUTION: A temporary fastening tool 1 temporarily fastening a screwing member to a part screwed of a workpiece comprises: a tool body 10; a knob 20 which is arranged on the tool body 10; at least one socket 40 with a rotational axis which is rotatably supported by the tool body 10 and has a bottom face 42 contacting a head 81 of the screwing member 80; a transfer mechanism 30 which transfers rotation drive force inputted into the knob 20 to the socket 40; a socket tip end part 50 which protrudes from the bottom face 42 of the socket 40 and is inserted into a hole 84 or a groove 85 of the screwing member 80; a plurality of pins 60 which protrudes from the bottom face 42 of the socket 40 around the socket tip end part 50 and is inserted into the hole 84 or the groove 85 of the screwing member 80; and two magnets 70 which are arranged sandwiching the rotational axis and facing each other on the bottom face 42 of the socket 40.SELECTED DRAWING: Figure 1
Patent JP-2022144116-A (JP)
Title: Active noise controller
Inventor: WANG XUN
IPC: G10K11/178
Filed: 2021-03-18
Abstract: To provide an active noise controller which can reduce sound pressure of noise even if a transmission characteristic changes.SOLUTION: A coordination control unit 24 allows a booming noise control signal processing unit 20 to start feed-forward signal processing, sets a secondary path filter C^ in a narrow band noise control signal processing unit 22 after convergence when the secondary path filter C^ converges, and allows the narrow band noise control signal processing unit 22 to start feedback signal processing.SELECTED DRAWING: Figure 10
Patent JP-2022144130-A (JP)
Title: Drive circuit of high-side transistor, switching circuit, and controller of dc/dc converter
Inventor: ISHINO TSUTOMU
IPC: H03K19/0175
Filed: 2021-03-18
Abstract: To provide a drive circuit with reduced power consumption.SOLUTION: A pulse generator 410 generates a first pulse Sp1, and a second pulse Sp2 to become high for fixed time in response to a first edge and a second edge of an input signal HIN, respectively. In an open drain circuit 420, a first output node OUT1, and a second output node OUT2 become low in response to the first pulse Sp1 and a second pulse Sp2, respectively. A first current mirror circuit 430 returns first current I1 flowing to the first output node OUT1 of the open drain circuit 420. A second current mirror circuit 432 returns second current I2 flowing to the second output node OUT2 of the open drain circuit 420. A first latch circuit 440 transits states in response to third current I3 which is output of the first current mirror circuit 430, and fourth current I4 which is output of the second current mirror circuit 432.SELECTED DRAWING: Figure 2