baber/WOPTO huggingface dataset:
Patent NZ-589894-A (NZ)
Title: 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases
Inventor: RUBIO ROYO VICTOR
IPC: A61K31/425
Filed: 2009-06-15
Abstract: Disclosed is a use of a 5-sulfonyl-phenyl-thiazole compound of formula (l): wherein: R1 is selected from alkyl, cycloalkyl, aryl and heterocyclyl; R2 is selected from alkyl and cycloalkyl; and R3 is an alkyl radical, or a pharmaceutically acceptable salt, and/or solvate thereof, in the preparation of a medicament for the treatment of polyarthritis, spondiloarthropathies, glomerulonephritis, colagenopathies, tubulo-interstitial nephritis, metabolic syndrome, atherosclerosis, osteoarthritis, asthma, chronic obstructive pulmonary disease, interstitial lung disease, multiple sclerosis, demyelinating diseases, meningitis, encephalitis, meningoencephalitis, inflammatory radiculopathies and peripheral neuropathies, inflammatory bowel disease, cirrhosis, hepatitis, heart failure, ischemic disease, renal failure, inflammatory cystitis, benign prostatic hyperplasia, prostatitis, myocarditis, pericarditis, uveitis, atopic dermatitis, eccema, urticaria, psoriasis, rosacea, allergic rhinitis, sepsis, septic shock, multiorganic failure, systemic autoimmune diseases such as systemic lupus erythematosus, vasculitis, dermatomyositis, amyloidosis or sarcoidosis, organ specific autoimmune diseases such as myasthenia gravis, or insulinitis, organ transplantation, infectious ant tumor induced inflammation, TNF-alpha dependent cellular degeneration, necrosis, apoptosis, graft versus host disease, cachexia and autocrine and paracrine pathological cell growth. Also disclosed is a compound of formula (I) when R2 - cyclopentyl, R1 is alkyl, cycloalkyl, aryl and heterocyclyl, R3 = alkyl.
Patent NZ-590472-A (NZ)
Title: Ophthalmic device having therapeutic agent delivery capability and method of forming same
Inventor: THOMES BRETT E
IPC: A61F2/16
Filed: 2009-07-20
Abstract: Disclosed is an ophthalmic device, comprising; a mass of material, the mass of material including a hydrophobic component, the hydrophobic component being present in an amount sufficient that the contact angle of the material is greater than 50 degrees, the hydrophobic component being formed of at least 80 per cent by weight hydrophobic acrylate; and therapeutic agent disposed upon a peripheral surface of the mass of material wherein the therapeutic agent is hydrophobic and has a partition coefficient Log P that is at least 1.0; wherein the mass of material is configured for insertion into an eye of a human and wherein attraction of the therapeutic agent to the hydrophobic acrylate provides for sustained release of the therapeutic agent such that less than 80 per cent by weight of the therapeutic agent is released from the mass of material over a period that is at least three days when the mass is submerged in basic salt solution.
Patent NZ-595122-A (NZ)
Title: Drilling down-the-hole apparatus with gearing to make cutter orbit at greater speed than drill rotational speed
Inventor: RUPP MICHAEL D
IPC: E21B3/02
Filed: 2010-03-26
Abstract: A down-the-hole assembly includes a housing having a central axis and a mechanical gear box positioned within the housing. The mechanical gear box is coupled to the housing such that rotation of the housing at a first rotational rate provides a rotary input to the mechanical gear box. A rotary cutting bit is coupled to the mechanical gear box. The mechanical gear box is configured to rotate said rotary cutting bit at a second rotational rate in response to that rotary input from the housing. The second rotational rate is greater than the first rotational rate. The mechanical gear box is also further configured to cause the rotary cutting bit to orbit about the central axis of the housing.
Patent NZ-596171-A (NZ)
Title: Hiv vaccine based on targeting maximized gag and nef to dendritic cells
Inventor: BANCHEREAU JACQUES F
IPC: A61K39/395
Filed: 2009-07-16
Abstract: A vaccine that comprises a dendritic cell (DC)-specific antibody to which an engineered antigen comprising Cyclin D1 is attached to form an antibody-antigen complex. The Cyclin D1 has been engineered to be less susceptible to proteolytic degradation by eliminating one or more proteolytic sites.
Patent NZ-596902-A (NZ)
Title: Glycomacropeptide medical foods for nutritional management of phenylketonuria and other metabolic disorders
Inventor: NEY DENISE M
IPC: A61K38/17
Filed: 2010-06-11
Abstract: Patent No. 596902 Disclosed is a medical food for the management of a metabolic disorder, comprising glycomacropeptide (GMP) and supplemented amounts of two or more amino acids, wherein one of the supplemented amino acids is arginine and the weight ratio within the medical food of the amino acid arginine to the total protein is from about 60 to 90 milligrams arginine/gram total protein, and wherein another of the supplemented amino acids is leucine and the weight ratio within the medical food of the amino acid leucine to the total protein is from about 100 to 200 milligrams leucine/gram total protein.
Patent NZ-597390-A (NZ)
Title: Pliers for removing staples from fencing with studs which act as a fulcrum
Inventor: JOHNSTONE CHRISTOPHER HENRY
IPC: B25C11/00
Filed: 2011-12-23
Abstract: 597390 Disclosed is a pair of pliers (1) for removing staples from fence posts. The pliers have a jaw portion (2), a hinge portion (3), and a handle portion (4). The jaw portion (2) comprises a first (5) and second (6) jaw. The tip (7, 8) of each jaw portion (5, 6) is tapered to a relatively fine tip to facilitate insertion into the crook of a fence staple (10) and above the wire (11). The aperture (12) formed between the closed jaws (5, 6) accommodates the head of the staple to prevent it being cut or damaged (making removal impossible). Adjacent the tips (7, 8) are raised stud-like projections (15, 16) whose top surfaces form primary load bearing surfaces that can act as fulcrums.
Patent NZ-598767-A (NZ)
Title: User acknowledgement device in electronic utility meter
Inventor: REE BRADLEY RICHARD
IPC: G01D7/00
Filed: 2012-03-13
Abstract: An electronic utility meter is disclosed. The utility meter comprises: a metering circuit; a switch operatively coupled to the metering circuit for switching the metering circuit between different states; a cover enclosing the metering circuit and switch; and a sensor enclosed within the cover coupled to the switch, where the sensor is configured to change a state of the switch in response to user interaction with the cover. The sensor includes a microelectromechanical systems (MEMS) accelerometer programmed to sense a predetermined tapping pattern of the user on the cover and the switch includes a remote disconnect switch with an off position, an armed position, and an on position.
Patent NZ-599739-A (NZ)
Title: Wind turbine with lightning protection system having pick-up unit positioned on rotation axis of turbine
Inventor: LEWKE BASTIAN
IPC: F03D11/00
Filed: 2012-05-02
Abstract: A wind turbine (1) including a lightning protection system. The lightning protection system comprises at least one insulated high-voltage cable (12a), a pick-up unit (14) positioned on the rotation axis of the wind turbine and an additional insulated high-voltage cable (12b). The at least one insulated high-voltage cable is electrically connected to a lightning receptor and to the pick-up unit. The pick-up unit is electrically connectable to an electrically grounded member (5, 6) by means of the additional insulated high-voltage cable.
Patent NZ-599843-A (NZ)
Title: Signaling for flexible carrier aggregation
Inventor: LARSSON MAGNUS
IPC: H04L5/00
Filed: 2010-11-04
Abstract: Disclosed is a flexible carrier aggregation method for use in a radio communications system. The method includes determining a capability to communicate over a radio interface (28, 48) using multiple radio frequency component carriers. Each of the multiple component carriers is configurable with one or more control channels in a first mode of operation and with no control channels in a second mode of operation. The method also includes signalling configuration information for at least one of the multiple radio frequency component carriers indicating at least one of the component carriers is configured to operate in a selected one of the first mode of operation and the second mode of operation so that a network radio node (20) and a user equipment radio node (40) can communicate using the selected mode of operation.
Patent NZ-600976-A (NZ)
Title: Automated teller machine system
Inventor: NAMBIAR ANANT
IPC: G06Q20/18
Filed: 2010-12-02
Abstract: A system and a method for processing an Automated Teller Machine (ATM) transaction to dispense cash using a transaction card associated with a first credit line account. The system comprises a payment network having at least one debit switch. The debit switch is configured to receive a transaction request. The transaction request includes account information corresponding to a first credit line account read from the transaction card by the ATM, and a request to perform the A TM transaction. The debit switch is configured to determine whether an owner of the first credit line account has associated a second demand deposit account. The second demand deposit account is capable of processing the transaction request; and the debit switch is configured to responsive to a determination that the owner of the first account has associated a second demand deposit account capable of processing the transaction request, forward the transaction request to a financial institution network associated with the second demand deposit account.
Patent NZ-612738-A (NZ)
Title: Retail point seed treatment sytems and methods
Inventor: REINECCIUS GREG A
IPC: G06Q50/02
Filed: 2011-12-08
Abstract: An automated seed treatment system is adapted for on-site operation at a retail seed distributor. A sealed seed-treater vessel is configured to apply a plurality of chemical treatments to a batch of seed based on a seed treatment recipe. A programmable system controller is electrically coupled to a pump controller of each of a plurality of pump-stations. The programmable system controller is configured to receive a material transfer indication from each of the plurality of pump-stations and issue commands to the pump controller of each pump-station in response to the seed treatment recipe. The programmable system controller is configured to collect operational data representing at least consumption of chemical from the chemical container at each of the pump-stations based on the corresponding material transfer indication during seed treatment and to provide the operational data to a remotely hosted information system located remotely from the site of the retail seed distributor and accessible to at least one third party that is distinct from the retail seed distributor.
Patent NZ-628087-A (NZ)
Title: Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same
Inventor: LEE CHRISTOPHER A
IPC: A61P35/00
Filed: 2010-12-21
Abstract: The disclosure relates to a form 1 and form 2 polymorph of (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione. The present disclosure also relates to (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4- (1H-indol-3-yl) pyrrolidine-2, 5-dione compounds having a chiral purity greater than 99%, and methods of preparation of these compounds. Also disclosed are pharmaceutical compositions comprising these (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione compounds, which are suitable for treating a cell proliferative disorder, such as a cancer.
Patent NZ-701722-A (NZ)
Title: Delivery of respiratory therapy
Inventor: GREGORY BRUCE DAVID
IPC: A61M16/06
Filed: 2007-07-27
Abstract: A sealing arrangement for a patient interface adapted to deliver to a patient pressurized breathable gas above ambient pressure for treatment of sleep disordered breathing, the sealing arrangement comprising a sealing portion (252) being adapted to, in use, provide an effective seal with the patient’s nose, the sealing portion being configured to engage an underside of the patient’s nose to seal therewith and/or cradle and seal with the patient’s external nares. The sealing portion has a laminated or multi-layer construction.
Patent NZ-701894-A (NZ)
Title: Dimethyl-benzoic acid compounds
Inventor: VETMAN TATIANA NATALI
IPC: C07D401/04
Filed: 2013-06-20
Abstract: The present invention provides a compound of the Formula II, wherein A is one of the four substructures shown in the accompanying figure; R1 is CH3, CF3, or F; R2 is H, CH3, or F; R3 is CH3, OCH3, OH, F; R4 is OH or CH2OH; and X is CH or N; or a pharmaceutically acceptable salt thereof. These compounds are selective EP4 inhibitors and are useful for the treatment of inflammatory conditions such as arthritis.
Patent NZ-706151-A (NZ)
Title: Modulation of androgen receptor expression
Inventor: MACLEOD ROBERT
IPC: A61K31/712
Filed: 2013-10-11
Abstract: Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation. Several embodiments provided herein relate to the discovery of compounds and compositions for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting proliferation or growth of cancer cells, such as prostate, breast, ovarian, gastric or bladder cancer or cancer cells.
Patent NZ-711145-A (NZ)
Title: Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
Inventor: GOCAL GREGORY
IPC: C12N15/11
Filed: 2014-03-14
Abstract: The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms. In particular, the invention provides a method for introducing a gene repair oligonucleobase (GRON)-mediated mutation into a target DNA sequence in a plant cell, comprising delivery of a GRON and a site-specific nuclease selected from the group consisting of a zinc finger nuclease (ZFN), a TALEN and a CRISPR complex into a plant cell. The GRON hybridizes at the target DNA sequence to create a mismatched base-pair(s), which acts as a signal to attract the cell’s gene repair system to the site where the mismatched base-pair(s) is created, and is degraded after designated nucleotide(s) within the target DNA sequence is corrected by the cell’s gene repair system such that the plant cell introduces the GRON-mediated mutation into the target DNA sequence and the plant cell is non-transgenic following the introduction. The GRON comprises one or more alterations from conventional RNA and DNA nucleotides at the 5’ or 3’ end.
Patent NZ-714579-A (NZ)
Title: Sustainable method and system for treating water bodies affected by bacteria and microalgae at low cost
Inventor: FISCHMANN TORRES FERNANDO BENJAMIN
IPC: C02F1/68
Filed: 2011-09-12
Abstract: Disclosed is a system for treating and maintaining a body of water affected by bacteria and microalgae at low cost by filtering a small fraction of the total volume of the body of water, the system comprising: - at least one inlet line for feeding water to at least one containing means; - at least one containing means comprising a receiving means for settled particles that is fixed to a bottom surface of said containing means, wherein the containing means has a volume of at least 15,000 m3; - at least one chemical application means; - at least one non-intrusive mobile suction means for moving along the bottom of said at least one containing means and suctioning water containing settled particles; - at least one propelling means for moving at least one non-intrusive mobile suction means along the bottom of said at least one containing means; - at least one coupling means that connects said at least one propelling means to said at least one suction means; - at least one filtration means for filtering water containing settled particles; - at least one collecting line coupled between said at least one mobile suction means and said at least one filtration means; - at least one return line from said at least one filtration means to said at least one containing means; and - at least one coordination means, wherein the coordination means is capable of receiving information regarding water quality parameters, processing that information, and activating non-intrusive mobile suction means and filtration means to adjust parameters of the water within predetermined limits.
Patent NZ-717998-A (NZ)
Title: Improved process for the humanization of animal skim milk
Inventor: VERDURMEN RUDOLPH EDUARDUS MARIA
IPC: A23C9/142
Filed: 2014-09-19
Abstract: Claimed is the preparation of an infant formula base product, comprising: (a) microfiltration (ME) of animal skim milk over a membrane having a porosity of 0.10 - 0.35 micrometer and operating with a volume concentration factor of 1.5 - 8, resulting in a retentate (MFR) and a permeate (MFP); (b) ultrafiltration (UF) of the MEP originating from step (a) over a membrane having a molecular weight cut-off of at most 25 kDa and operating with a volume concentration factor of 1.5 - 8, resulting in a retentate (UFR) and a permeate fUEP); (c) combining the MFR from step (a) and the UFR from step (b), to obtain a defined casein/whey ratio. Alternatively, the product of step (a) is used as a protein source. Claimed is also a composition comprising 40 - 50 g casein, 30 - 40 g lactose and 5 - 16 g ash per 100 g dry weight.
Patent NZ-729632-A (NZ)
Title: Apparatus for treating animals
Inventor: KELLY MARK
IPC: E04H1/12
Filed: 2015-08-06
Abstract: An animal treatment apparatus comprising a chamber defining an enclosure within which one or more animals may be housed during treatment with a treatment liquid, a plurality of spray nozzles being provided within the enclosure, said spray nozzles communicating with a reservoir containing a treatment liquid, a pump being provided for pumping said liquid from the reservoir to said spray nozzles to drench the one or more animals located within said chamber with said treatment liquid. The apparatus prevents external contamination by the treatment liquid.
Patent NZ-735684-A (NZ)
Title: Materials and methods for respiratory disease control in canines
Inventor: CRAWFORD PATTI C
IPC: C12N7/00
Filed: 2006-10-19
Abstract: Disclosed is a isolated influenza virus that is capable of infecting a canid animal, wherein said influenza virus comprises a polynucleotide which encodes a polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 64, 66, 68, 70, 72, 74, or 76, or a functional and/or immunogenic fragment thereof, or said polynucleotide encodes a polypeptide having 99% or greater sequence identity with the amino acid sequence shown in any of SEQ ID NOs: 66, 68, 70, 72, or 74; or wherein said influenza virus comprises a polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 64, 66, 68, 70, 72, 74, or 76, or a functional and/or immunogenic fragment thereof, or a polypeptide having 99% or greater sequence identity with the amino acid sequence shown in any of SEQ ID NOs: 66, 68, 70, 72, or 74. Also disclosed are canine influenza vaccines, wherein the vaccine comprises a therapeutically effective amount of an influenza virus as defined herein. Further disclosed are cells expressing said virus and uses thereof.
Patent NZ-738636-A (NZ)
Title: Method and compositions for cellular immunotherapy
Inventor: JENSEN MICHAEL
IPC: C12N15/62
Filed: 2013-08-20
Abstract: The invention relates to a nucleic acid encoding a chimeric receptor, the chimeric receptor comprising: (a) an extracellular domain consisting of: an extracellular ligand binding domain consisting of a single chain variable fragment (scFv) that binds to a CD19, wherein the scFv comprises a variable light chain (VL) domain comprising a CDRL1, a CDRL2, and a CDRL3 of the amino acid sequence encoded by SEQ ID NO:3, and a variable heavy chain (VH) domain comprising a CDRH1, a CDRH2, and a CDRH3 of the amino acid sequence encoded by SEQ ID NO:3; and an extracellular polypeptide spacer that is about 15 amino acids or less in length and comprises an amino acid sequence of X1PPX2P, wherein X1 is a cysteine, glycine, or arginine and X2 is a cysteine or a threonine (SEQ ID NO:1); (b) a transmembrane domain; and (c) an intracellular signaling domain that comprises a CD3ζ signaling domain and a costimulatory domain. Also provided is a nucleic acid encoding a chimeric receptor, the nucleic acid comprising: (a) a polynucleotide encoding a single chain variable fragment (scFv) that binds to CD19, wherein the scFv comprises: a variable light chain (VL) domain comprising a VL domain present in the amino acid sequence encoded by SEQ ID NO:3, and a variable heavy chain (VH) domain comprising a VH domain present in the amino acid sequence encoded by SEQ ID NO:3; or the amino acid sequence encoded by SEQ ID NO:3; (b) a polynucleotide encoding a transmembrane domain; (c) a polynucleotide encoding a polypeptide spacer located between the scFv and the transmembrane domain, wherein the polypeptide spacer is about 15 amino acids or less in length and comprises an amino acid sequence of X1PPX2P, wherein X1 is a cysteine, glycine, or arginine and X2 is a cysteine or a threonine (SEQ ID NO:1); and (d) a polynucleotide encoding an intracellular signaling domain that comprises a CD3ζ signaling domain and a costimulatory domain. Also provided are vectors that include the nucleic acids and methods of using the nucleic acids and vectors.
Patent NZ-740900-A (NZ)
Title: Mice that make binding proteins comprising vl domains
Inventor: MACDONALD LYNN
IPC: C12N15/85
Filed: 2011-08-02
Abstract: Disclosed are targeting vectors comprising a first and second targeting arm directing the targeting vector to an endogenous mouse immunoglobulin heavy chain gene locus, and a contiguous sequence comprising unrearranged human VL gene segments, optionally with an unrearranged human JL gene segment; wherein homologous recombination with the targeting vector creates a hybrid immunoglobulin gene locus comprising the unrearranged human VL and optionally JL gene segments operably linked with an endogenous mouse immunoglobulin heavy chain gene locus. Further disclosed are isolated host cells comprising said targeting vectors and methods for making a genetically modified mouse using said targeting vectors.
Patent NZ-744845-A (NZ)
Title: Cancer treatment
Inventor: KENYON JULIAN
IPC: A61K38/43
Filed: 2017-01-27
Abstract: The present invention relates to compositions, methods, uses and kits for treating cancer. The present invention relates to methods for minimising the progression of cancer in a subject, the method comprising administering to the subject therapeutically effective amounts of chymotrypsinogen and trypsinogen, thereby minimising the progression of cancer in the subject. In particular, the methods provide a means for treating cancer by reducing the number of cancer stem cells in the subject.