Patent SG-11201808270P-A (SG)
Title: Substituted indoline derivatives as dengue viral replication inhibitors
Inventor: BARDIOT DOROTHÉE ALICE MARIE-EVE
IPC: C07D209/26
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010 11111 0111011110011111B1011001111101111011 1111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/167953 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 209/26 (2006.01) A61P 31/12 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/404 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/057663 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 31 March 2017 (31.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 16163281.5 31 March 2016 (31.03.2016) EP (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: JANSSEN PHARMACEUTICALS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, New Jersey 08560 (US). KATHOLIEKE UNI- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 3000 Leuven (BE). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: BARDIOT, Dorothee Alice Marie-Eve; c/o SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, — Cistim Leuven vzw, Gaston Geenslaan 2, 3001 Leuven GW, KM, ML, MR, NE, SN, TD, TG). — (Heverlee) (BE). BONFANTI, Jean-Francois; c/o Declarations under Rule 4.17: _ Janssen-Cilag, 1 rue Camille Desmoulins, TSA 91003, — as to applicant's entitlement to apply for and be granted a 92787 Issy-les-Moulineaux Cedex 9 (FR). KESTELEYN, 4.1700) = patent (Rule c/o Janssen Bart Rudolf Romanie; Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse MARCHAND, Published: (BE). Arnaud Didier M; Cistim Leuven Gaston Geens- c/o vzw, - with international search report (Art. 21(3)) laan 2, 3001 Leuven RABOISSON, = (Heverlee) (BE). Pierre Jean-Marie Bernard; c/o Janssen Pharmaceutica — with sequence listing part of description (Rule 5.2(a)) NV, Turnhoutseweg 30, 2340 Beerse (BE). (74) Agent: VERBERCKMOES, Filip; J&J Patent Law De- = partment, Turnhoutseweg 30, 2340 Beerse (BE). = = = = = = = = 1-1 M kr) 0\ IN 1-1 (54) Title: SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS 1-1 C (57) : The present invention concerns substituted indoline compounds, methods to prevent or treat dengue viral infections ei by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or 0 prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara- tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.