Patent EP-1649849-A2 (EP)
Inventor: BENAVIDES JESUS
IPC: A61K31/4427
Filed: 2002-08-28
Abstract: Composition comprise: (a) products that activate dopaminergic neurotransmission in the brain; and (b) azetidine CB1 antagonist (I) - (IV), their optical isomers or salts. Composition comprise: (a) products that activate dopaminergic neurotransmission in the brain; and (b) azetidine CB1 antagonist of formula (I) - (IV), their optical isomers or salts. [Image] In (I) and (II): R 1H, alkyl, -NH-R 1 5, CN, -S-alk-NR 1 6R 1 7, -CH 2-NR 1 8R 1 9 or -NR 2 0R 2 1; R 2-C(R 8)(R 9)(R 1 0), -C(R 8)(R 1 1)(R 1 2), -CO-NR 1 3R 1 4, -CH 2-CO-R 6, -COR 6, -CO-cycloalkyl, -SOR 6, -C(OH)(R 6)(alkyl), -C(=NOalk)R 6, -C(=NO-CH 2-CH=CH 2)R 6, -CH 2-CH(R 6)NR 3 1R 3 2, -CH(R 6)NHSO 2-alk, -CH(R 6)NHCONH-alk or -CH(R 6)NHCO-alk; R 3, R 4(cyclo)alkyl, phenyl, naphthyl, indenyl (optionally substituted os by T 1, formyl, -CO-alk, -COOH, -CONR 2 2R 2 3 -CONH-NR 2 4R 2 5 or alk-NR 2 4R 2 5), or heteroaromatic (os by T 1, -COOH or -CONHNR 2 4R 2 5); T 1halogen, (hydroxy)alkyl, alkoxy, OH, CF 3, CF 3O-, CN, -COOalkyl, alkylsulfanyl(alkyl), alkylsulfinyl(alkyl) or alkylsulfonyl(alkyl); R 5, R 8, R 13, R 18H or alkyl; R 6, R 10Ar 1 or Het 1; R 7(hetero)cycloalkyl, or heterocyclalkenyl os by -CSO-phenyl; R 9-CO-NR 2 6R 2 7, -COOH, -COOalk, -CH 2OH, -NH-CO-NH-alk, -CH 2-NHR 2 8, or -NHCOOalk; R 1 1-SO 2-alk, -SO 2-Ar 1, or -SO 2-Het 1; R 1 2H, Ar 1 or Het 1; R 1 4Ar 1, Het 1, -alk-Ar 1 or -alk-Het 1; R 1 5(cyclo)alkyl, or alk-NR 2 9R 3 0; R 1 6, R 1 7H or alkyl; or NR 1 6R 1 7T 2; T 2mono or bicyclic (un)saturated 3 - 10 membered heterocycle which may contain heteroatoms (O, N, S) and may be os by alkyl; R 1 9H, (cycloalkyl), cycloalkylalkyl, cycloalkylcarbonyl, -SO 2-alk, -CONH-alk, or -COO-alk; or NR 1 8R 1 9, NR 2 2R 2 3T 2; NR 2 0R 2 1T 3; T 3= a monocyclic (un)saturated 3 - 8 membered heterocycle which may contain heteroatoms (O, N, S); R 2 4, R 2 5= H, -COO-alk, (cyclo)alkyl, alkylcycloalkyl, -alk-O-alk, hydroxyalkyl; or NR 2 4R 2 5T 3 (os by (hydroxy)alkyl, -CO-alk, -COO-alk, -CO-NH-alk, -CS-NH-alk, oxo, -alk-O-alk-, or -CONH 2); R 2 6, R 2 7H, (hydroxy)alkyl, cycloalkyl(alkyl), -alk-COOalk, -alk-Ar 1, alk-het 1, Het 1, -alk-N(alk) 2; or NR 2 6R 2 7T 3 (os by alkyl, alkoxy or halogen); R 2 8-CH 2-alk, benzyl, -SO 2-alk, -CONH-alk, -CO-alk, cycloalkyl(alkyl)carbonyl, or -CO-(CH 2) n-OH; n : 1 - 3; R 2 9, R 3 0H or alkyl; or NR 2 9R 3 0T 2; R 3 1, R 3 2H, alkyl, Ar 1, or alk-Ar 1; or NR 3 1R 3 2aziridinyl, pyrrolidinyl or piperidinyl; Ar 1= phenyl or naphthyl, os by halogen, (hydroxy)alkyl, alkoxy, -CO-alk, CN, -COOH, -COO-alk, -CONR 2 2R 2 3, -CONH-NR 2 4R 2 5, alkylsulfanyl(alkyl), alkylsulfinyl(alkyl), alkylsulfonyl(alkyl), -alk-NR 2 4, -NR 2 4R 2 5, alkylthioalkyl, formyl, OH, CF 3, OCF 3, Het 1, -O-alk-NH-cycloalkyl or -SO 2NH 2; Het 1T 3 os by (hydroxy)alkyl, halogen, alkoxy(carbonyl), -CONR 2 2R 2 3, O, oxo or -SO 2NH 2; alk : alkyl or alkylene; and provided that when R 1 is H, then R 2 is -C(R 8)(R 9)(R 1 0), -C(R 8)(R 1 1)(R 1 2), -CO-NR 1 3R 1 4, -CH 2-CO-R 6, -COR 6, -CO-cycloalkyl, -SOR 6, -C(OH)(R 6)(alkyl), -C(=NOalk)R 6, -C(=NO-CH 2-CH=CH 2)R 6, -CH 2-CH(R 6)NR 3 1R 3 2, -CH(R 6)NHSO 2-alk, -CH(R 6)NHCONH-alk, or -CH(R 6)NHCO-alk, or when R 1 is alkyl, -NH-R 1 5, CN, -S-alk-NR 1 6R 1 7, -CH 2-NR 1 8R 1 9 or -NR 2 0R 2 1, then R 2 is -C(R 8)(R 1 1)(R 1 2). N.B. R 7 is defined but does not appear in formulae or list of definitions. In (III): R 3 3-NHCOR 3 4, or -N(R 3 5)-Y-R 3 6; Y : CO or SO 2; R 3, R 4phenyl, naphthyl, indenyl (os by T 1 (except halogen), formyl, -CO-alk, -COOH, -CONR 3 7R 3 8, -CONHR 3 9R 4 0 or alk-NR 3 7R 3 8), heteroaromatic os by T 1 (except halogen) -COOH or -CONHNR 2 4R 2 5; R 3 4-alk-SO 2-R 4 1, alk-SO 2-CH=CH-R 4 1, Het 2 substituted by -SO 2-R 4 1 or -alk-SO 2-R 4 1; R 3 5H or alkyl; R 3 6phenylalkyl, Ar 2 or Het 2; R 3 7, R 3 8H or alkyl; or NR 3 7R 3 8T 2; R 3 9, R 4 0H, -COOalk, (cyclo)alkyl, alkylcycloalkyl, alk-O-alk or hydroxyalkyl; or NR 3 9R 4 0T 3 os by (hydroxy)alkyl, -CO-alk, -COO-alk, -CONH-alk, -CS-NH-alk, oxo, -alk-O-alk, or CONH 2; R 4 1alkyl, Ar 2, or Het 2; Ar 2phenyl, naphthyl or indenyl, os by T 1 (except OH) -CO-alk, -COOH, -CONR 4 2R 4 3, -CONH-NR 4 4R 4 5, Het 2, -O-alk-NH-cycloalkyl, -NH-CO-alk, -SO 2-NH 2, -NH-COCH 3, -NH-COO-alk, or two adjacent C atoms may be linked by dioxymethylene; Het 2T 3 os by alkyl, vinyl, halogen, alkoxy(carbonyl), oxo, OH, OCF 3 or CF 3, and their N-oxides; R 4 2, R 4 3H or alkyl; or NR 4 2R 4 3T 2; R 4 4, R 4 5H, -COO-alk, (cyclo)alkyl, alkylcycloalkyl, -alk-O-alk or hydroxyalkyl; or NR 4 4R 4 5T 3 os by (hydroxy)alkyl, -CO-alk, -COO-alk, -CONH-alk, -CS-NH-alk, oxo, -alk-O-alk, or CONH 2. In (IV): R 4 6-N(R 4 7)(R 4 8), -N(R 4 7)CO(R 4 8), or -N(R 4 7)-SO 2(R 4 9); R 3, R 4phenyl, naphthyl, indenyl (os by T 1, formyl, -CO-alk, -COOH, -CONR 3 7R 3 8, -CONHR 3 9R 4 0 or alk-NR 3 7R 3 8), heteroaromatic os by -COOH, -CONHNR 5 2R 5 3, -CONR 5 0R 5 1 or -alk-NR 5 2R 5 3; R 4 7-C(R 5 4)(R 5 5)-Het 3, Het 3, - C(R 5 4)(R 5 5)-Ar 3, Ar 3, cycloalkyl or norbornyl; R 4 8, R 4 9H, hydroxyalkyl, -alk-COO-alk, -alk-CONR 5 0R 5 1, alkoxy, Ar 3, Het 3, -CH 2-Het 3 or (halo)alkyl; R 5 0, R 5 1H or alkyl; or NR 5 0R 5 1T 2; R 5 2, R 5 3H, -COOalk, (cyclo)alkyl, alkylcycloalkyl, -alk-O-alk or hydroxyalkyl; or NR 5 2R 5 3T 3 os by (hydroxy)alkyl, -CO-alk, -COO-alk, -CONH-alk, -CS-NH-alk, oxo, -alk-O-alk, or CONH 2; R 5 4H, hydroxyalkyl, -alk-COO-alk, -alk-CONR 5 0R 5 1, alk-NR 5 0R 5 1, alkoxyalkyl, Ar 3, Het 3, -CH 2Ar 3, -CH 2-Het 3 or (halo)alkyl; R 5 5H, hydroxyalkyl, -alk-COO-alk, -alk-CONR 5 0R 5 1, -alk-NR 5 0R 5 1, alkoxyalkyl, alkyl (os by halogens), or T 2; Ar 3phenyl, naphthyl or indenyl, os by halogen, (hydroxy)alkyl, alkoxy, -CO-alk, CN, -COOH, -COO-alk, -CONR 5 6R 5 7, -CONH-NR 5 8R 5 9, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, alk-NR 5 8R 5 9, NR 5 8R 5 9, alkylthioalkyl, formyl, OCF 3, CF 3, Het 3, -O-alk-NH-cycloalkyl, SO 2NH 2, OH, -NH-CO-alk, -NH-COO-alk, or two adjacent C atoms may be linked by dioxymethylene; Het 3T 3 os by alkyl, halogen, alkoxy(carbonyl), oxo, or OH, and their N-oxides; and R 5 6, R 5 7, or R 5 8, R 5 9H; or NR 5 6R 5 7, NR 5 8R 5 9T 2; Alkyl, alkoxy and alkylene groups have 1-6C atoms, and cycloalkyl groups have 3-10C atoms. ACTIVITY : Antiparkinsonian. MECHANISM OF ACTION : CB1 receptor antagonist; Dopaminergic neurotransmission activator.