baber/WOPTO huggingface dataset:
Patent DK-47389-D0 (DK)
Inventor: ANDERSON LESLIE D
IPC: A61K51/10
Filed: 1989-02-02
Abstract: The present invention discloses a method for modifying the pharmacokinetics of a hapten which is useful as an in vivo radioimaging or radiotherapeutic agent. Compositions comprising a derivatized hapten of the invention are provided for in vivo imaging and therapy. A compound of Formula (I):  p-R1-C6H4-CH2-EDTA-M      (I)    wherein R1is -NH- @-NH-R2,    - @-NH-R2,  -NH- @-CH2-R2, -NH- @-CH2-NH-R2,    -NH-R2, -NH- @-NH-R2    or -NH- @-CH2-S-R2; R2 is hydrogen, an amino group, -OC @Y), -p-phenyl-CH2-Y, an unsubstituted C1 to C30 branched or straight chain alkyl group; a substituted C1 to C30 branched or straight chain alkyl, cycloalkyl, aryl or arylalkyl group, in which the substituents are one or more of any of:  hydroxy, carboxy, =O, =S,  - @=O, - @=S   -S-, -SR4, fluoro, chloro, bromo, iodo, amino, nitro, -SO3H, -NHR3, -NHR4, -N(R3)2, -CONHR3, -COOR3, -SO4, -PO4, phenyl, benzyl, imidazolo, or a group of the formulae:  -NH- @@NH-R3, -NH- @-NH-R3    or NH- @-NH-R3;  wherein  R3 is hydrogen, a C1 to C30 straight or branched chain alkyl group,  -p-phenyl-CH2-Y,  - @-CH3,    or a non-reactive functional group;  Y is EDTA, DTPA, DOTA, HETA, TRITA or TETA;  R4 is H or -CH2- @-NHR3;    and, M is a metal ion, or a pharmaceutically-acceptable salt thereof.
Patent HU-910362-D0 (HU)
Title: Process for manufacturing reservoirs provided with cracking-off lock
Inventor: FLORK JEAN-LOUIS
IPC: B65D17/40
Filed: 1991-02-01
Abstract: Method of manufacturing a container comprising a body having an opening, a bead of heat-weldable material arranged in the proximity of the opening and a lid sealed to the bead. The heat-weldable bead (6) is injected in the proximity of the opening during the production of the body of the container (1) or during the operation of sealing the lid. <IMAGE>
Patent DK-109486-D0 (DK)
Inventor: SEEBACH DIETER
IPC: A61P29/00
Filed: 1986-03-10
Abstract: Cyclosporins e.g. of formula IIin whichX is -MeBmt- or -dihydro-MeBmt- andY is -aAbu-, Thr-, -Val- or -Nva-, wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, a-N-methylated a-aminoacid residue of the (D)-configuration, possess pharmaceutical, in particular immunosuppressive, anti-inflammatory and anti-parasitic activity. Intermediate cyclosporin poly-anions having a de-protonated sarcosyl residue at the 3-position, e.g. polyanions of cyclosporins of formula II above wherein X and Y have the meanings given above and Z is -Sar<sub>-</sub>, in which the said residue Z is de-protonated, are also novel and part of the invention.
Patent DK-155386-D0 (DK)
Inventor: KOOB KUNIBERT
IPC: E04B1/68
Filed: 1986-04-04
Abstract: An injection hose for construction joints in concrete structures includes an essentially liquid-impermeable base structure of flexible material such as rubber or synthetic material and defining a passage duct. The base structure has along its length radial openings for the escape of injection liquid from the passage duct and, along its length in the area of the radial openings, at least one longitudinal depression for receiving a strip of a material which is compressible under the pressure of the injection liquid and which covers the openings. A hose of liquid-permeable material surrounds the base structure and strip. A plurality of radial openings are provided in the base structure, and the associated depressions and strips are distributed around the circumference of the base structure angularly symmetrically in relation to the central longitudinal axis.
Patent DK-214187-D0 (DK)
Inventor: BYERS MICHAEL JOE
IPC: C12N5/00
Filed: 1987-04-27
Abstract: Nonanchorage-dependent cells are immobilized for cell culturing or the production of cell products, by contacting a medium comprising the cells with floc formed by the combination of positively and negatively charged ion exchange resins having an average particle size ranging from about 0.01 to about 1.5 micrometers. The flocs may be formed either prior to contact with the cells or may be formed in-situ in the cell-containing medium upon separate addition of the resins, preferably by first adding the positively charged resin followed by the negatively charged resin. The resin floc operates as a microcarrier for the cells and the immobilized nonanchorage-dependent cells may be cultured in suspension and maintained in perfusion culture with substantially reduced cell loss and without the need for specialized filters or other equipment.
Patent DK-402187-D0 (DK)
Inventor: BON CHARLES K
IPC: C25B3/25
Filed: 1987-07-31
Abstract: Nickel alloy anodes are suitable for electrochemical cells that are used for the selective replacement of chlorine in organochlorine compounds with hydrogen and are resistant to corrosion. Electrochemical cells containing Hastalloy C-276 anodes and silver cathodes, for example, are used to convert tetrachloropicolinic acid to 3,6-dichloropicolinic acid.
Patent DK-542683-D0 (DK)
Inventor: MEETH ERNST JOSEF
IPC: E05D7/082
Filed: 1983-11-28
Abstract: 1. Swivel bearing for roof surface windows or the like, consisting of a bearing base body (1) having a circular-ring-segment-shaped guide groove (2) in which a slider (3) is displaceably guided, characterised in that the circular-ring-segment-shaped slider (3) has a greater length than the guide groove (2) and in that the cross-section of the guide groove and of the slider widens towards the groove bottom.
Patent HU-9202751-D0 (HU)
Title: Method for controlling and regulating formation of primary seed crystals iniron melts
Inventor: BACKERUD STIG LENNART
IPC: C21C1/10
Filed: 1991-02-25
Abstract: PCT No. PCT/SE91/00144 Sec. 371 Date Oct. 22, 1992 Sec. 102(e) Date Oct. 22, 1992 PCT Filed Feb. 25, 1991 PCT Pub. No. W091/13176 PCT Pub. Date Sep. 5, 1991.A melt sample is taken in a sampling vessel which is in thermic equilibrium with the sample quantity prior to solidification commencing, the sampling vessel having been provided with at least one thermoelement and containing a determined and calibrated quantity of inoculating agent based on FeSi and sufficient to produce a maximum inoculating effect. The sample melt is allowed to solidify while temperature changes per unit of time are recorded. The difference between the minimum temperature in the undercooling phase, the maximum temperature in the eutectic reaction phase, and the eutectic equilibrium temperature Te, are determined. To the base melt are added thermodynamically stable particles of the type spinels, oxides or oxysulphides of elements such as magnesium, aluminium, potassium, zirconium, strontium, titanium and rare earth metals when the difference between eutectic equilibrium temperature Te and the minimum temperature in the undercooling phase exceeds 10 DEG  K. and when the difference between Te and the maximum temperature in the eutectic reaction phase exceeds 5 DEG  K. If found suitable, these method steps are repeated until those differences fall beneath 10 DEG  K. and 5 DEG  K., respectively.
Patent IT-8905118-D0 (IT)
Inventor: STRATHMANN HEINZ
IPC: F16J15/3284
Filed: 1989-02-20
Abstract: A seal for sealing between outer and inner parts, having a fixing portion and a sealing portion with at least one sealing lip, has its fixing portion and/or its sealing portion provided with a magnetised material so as to be magnetically attracted to the part it engages. Preferred embodiments are main seals 20 or secondary seals 19 for the journals and bearing cups of Hookes universal joints. <IMAGE>
Patent IT-8009323-D0 (IT)
Inventor: ATHOS NOVELLI GIOVANNI RINALDI
IPC: B22C1/02
Filed: 1980-01-21
Abstract: The invention refers to a granulated material for preparation of foundry molding sand, to be added to them to improve their composition, reduce pollution and handling problems, which consists of a refractory framework in the form of granules the size of which ranges from 0.1 to 0.4 mm and an external coating on said refractory framework which in turn consists of a fit material for providing lustrous carbon. The refractory framework is formed by a zircon sand, chamotte, chromite, olivine, sillimenite, mullite or mixtures thereof, with a free silice content not greater than 3 %. The invention also relates to a hot-process and a cold-process for production of said granulated material.
Patent NO-881990-D0 (NO)
Inventor: MILES RICHARD
IPC: C10L1/16
Filed: 1988-05-06
Abstract: Improved gasoline compositions containing a minor amount of a polyalphaolefin having a viscosity at 100 DEG C from 2 to 20 centistokes, and optionally also an aliphatic polyamine, an alkali or alkaline earth metal salt of a succinic acid derivative, and/or a polyolefin; together with a concentrate for the production of such gasoline composition and a method of operating a spark-ignition engine using such gasoline composition.
Patent NO-891506-D0 (NO)
Inventor: RICHTER JOHAN C F C
IPC: D21C9/18
Filed: 1989-04-12
Abstract: A pressure diffuser (10) for paper pulp includes a vertical pressurizable liquid-tight vessel (11) having a pulp inlet (12) at the bottom and a pulp outlet (13) at the top. One or more ring shaped screen elements (15), providing first and second concentric screen surfaces (16), are vertically mounted within the vessel. A number of radially extending header arms (18) mount the screen elements for movement in the vessel and in fluid communication with it. A first linear actuator (37) effects reciprocation of the arms. A cylinder (35), open at both ends, is affixed to the arms and extends both above and below them, and a piston (39) is disposed within the cylinder, below the arms. A second linear actuator (40) is operatively connected to the piston to effect reciprocation of the piston in the cylinder. A guiding conduit (46) surrounds the open end of the cylinder above the arms and guides reciprocation of the cylinder and transports liquid from the arms to an effluent outlet. A perforated jacket (57) surrounding the guiding conduit, nozzles (61) at the vessel wall, and the like introduce liquid into the vessel for treatment of the pulp. The ring shaped screen element is connected to the arms in a manner to allow the best liquid communication between them. In this way pulp can be effectively treated in a pressurized vessel while the screens for treating the pulp are periodically backflushed without causing a surge within the vessel.
Patent NO-903417-D0 (NO)
Inventor: KESKES NAAMEN
IPC: G01V1/30
Filed: 1990-08-03
Abstract: Method of processing seismic recordings for obtaining improved seismic seismic cross-sections by taking into account, during the summation, the actual geometrical configuration of the signal alignments over the individual recording acquisition points before summing. 
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Patent NO-915069-D0 (NO)
Inventor: CULLY JAN
IPC: A23L5/20
Filed: 1991-12-20
Abstract: To remove cyclodextrin residues from fats and oils, the latter are emulsified in water and the cyclodextrin is enzymatically degraded with the aid of at least one  alpha -amylase selected from the  alpha -amylases produced by microorganisms of the group Aspergillus niger, Aspergillus oryzae, Bacillus polymyxa, porcine pancreatic amylase, Bacillus coagulans and Flavobacterium, and/or of preferably a CTGase selected from the CTGases produced by bacteria of the group Bacillus, Klebsiella, Micrococcus and alkalophilic bacteria.
Patent NO-930670-D0 (NO)
Inventor: ORJALES-VENERO D AURELIO
IPC: A61K31/7048
Filed: 1993-02-25
Abstract: The diosmin heptakis (hydrogensulfate) aluminium complex is described, as well as its preparation procedure, characterized by reacting one mole of diosmin with seven moles of a sulfating agent in a dry medium and treatment with an aqueous aluminium hydroxycloride solution of the diosmin heptakis (hydrogensulfate) sodium salt thus obtained. A description of pharmacological assays carried out to confirm the citoprotective action of the product is included.
Patent NO-941766-D0 (NO)
Inventor: BYSTROM STEVEN R
IPC: B05B11/00
Filed: 1994-05-11
Abstract: A fluid dispensing system for delivering sterile preservative free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are positive acting, normally closed duckbill valves which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.
Patent NO-941936-D0 (NO)
Inventor: BULUSU A R C MURTY
IPC: C07D498/16
Filed: 1994-05-25
Abstract: The invention concerns the compounds of formula I <CHEM> wherein the substituents have various significances, in free form and, where such forms exist, in salt form. They can be prepared by various processes, e.g. by irradiation; oxidation; elimination; reduction; conversion by e.g. halogenation or acylation; deprotection of protected hydroxy groups; protection of free hydroxy groups; and separation of stereoisomeric mixtures into individual isomers. They are indicated for use as pharmaceuticals, especially as antiinflammatory, and as antiproliferative and antiinflammatory agents.
Patent NO-953065-D0 (NO)
Inventor: JONKERS GODEFRIDUS HUBERTUS JO
IPC: B65D43/02
Filed: 1995-08-04
Abstract: PCT No. PCT/NL94/00298 Sec. 371 Date Sep. 19, 1995 Sec. 102(e) Date Sep. 19, 1995 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15914 PCT Pub. Date Jun. 15, 1995A device for closing a cover onto a container, wherein the cover and the container each have a protruding flanged edge which come to lie against each other in the closing position and wherein a hook-shaped cam connected to the cover co-acts with a counter-cam connected to the container for the purpose of locking the cover onto the container, wherein both flanged edges have continuous slotted holes in a corresponding pattern, wherein a wedge-shaped hand-tool can be placed into two mutually registering holes in the flanged edges to turn the cover in relation to the container, such that the hook-shaped cam connected to the cover comes into engagement with the counter-cam, whereby with a simple tool all locks are placed simultaneously in or out of engagement during closing or release of the cover.
Patent NO-953555-D0 (NO)
Inventor: KLEEMANN HEINZ-WERNER
IPC: C07D215/60
Filed: 1995-09-08
Abstract: Benzoyl guanidine derivs. of formula (I) and their salts are new: one of R1-R3 = Het (linked by C or N), SR10, OR10, NR10R11 or CR10R11R12; and the other two of R1-R3 = H, halo, CN, X(CH2)p(CqF2q+1), SOuR22, CONR23R24, COR25, SO2NR26R27, 1-8C alkyl, 2-8C alkenyl, CmH2mR14, OR35 or NR35R36; R4, R5 = H, 1-4C alkyl, Fl, Cl, OR32, NR33R34 or CrF2r+1; R10 = CnH2n-Het; Het = 1-9C heteroaryl-N-oxide (opt. substd. by 1-3 F, Cl, CF3, OMe, OH, NH2, NHMe or NMe2); R11, R12 = as R10, H or 1-4C alkyl; R14 = 3-9C cycloalkyl or phenyl (opt. by 1-3 F, Cl, CF3, Me, OMe, NH2, NHMe or NMe2); R11, R12 = as R10, H or 1-4C alkyl; R14 = 3-8C cycloalkyl or phenyl (opt. substd. by 1-3 F, Cl, CF3, Me, OMe, NH2, NHMe or NMe2); X = a bond, O, S or NR28; R22 = 1-8C alkyl, 2-6C alkenyl, CmH2mR29 or CF3; R23, R25, R26 = H or as R22; R24, R27 = H or 1-4C alkyl; or R23 + R24, R26 + R27 = (CH2)4 or (CH2)5 (both opt. with a CH2 replaced by O, S, NH, NMe or N-benzyl); R28 = H or 1-3C alkyl; R29 = 3-7C cycloalkyl or phenyl (opt. mono- or tri-substd. by F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35 + R36 = (CH2)y (opt with a CH2 replaced by O, S, NH, NMe or N-benzyl); R32-R34 = H or 1-3C alkyl; n, p, u = 0-2; m = 0-4; r = 1-4; q = 0-6; y = 4-7. Also claimed are cpds. of formula (IIIA); A = Cl, OR45, OH, OM or imidazol-1-yl; M = alkali or alkaline earth metal ion; and R45 = 1-8C alkyl or 1-4C alkylphenyl.
Patent NO-954161-D0 (NO)
Inventor: PFISTER JURG ROLAND
IPC: C07D213/65
Filed: 1995-10-18
Abstract: 10,11-Methanodibenzosuberane derivatives, i.e., the compounds of Formula I: <CHEM>  wherein:   A is -CH2-CH2-, -CH2-CHR<a>-CH2-, where R<a> is H, OH or lower acyloxy of the formula -O-C(=O)-R', wherein R' is a cyclic, branched or straight chain monovalent alkyl radical of 1-6 carbon atoms, or -CH2-CHR<a>-CHR<b>-CH2-, where one of R<a> or R<b> is H, OH, or lower acyloxy of the formula -O-C(=O)-R', wherein R' is a cyclic, branched or straight chain monovalent alkyl radical of 1-6 carbon atoms, and the other is H;   R<1> is H, F, Cl or Br;   R<2> is H, F, Cl or Br; and R<3> is heteroaryl excluding heteroaryl with 2 condensed rings and 1 to 3 heteroatoms selected from the group consisting of N, O and S; or phenyl optionally substituted with F, Cl, Br, CF3, CN, NO2 or OCHF2; and the pharmaceutically acceptable salts thereof, are useful chemosensitizing agents, e.g., for cancer chemotherapy, particularly for treating multidrug resistance.
Patent NO-962362-D0 (NO)
Inventor: LINDEN ERKKI OLAVI
IPC: B29C70/76
Filed: 1996-06-06
Abstract: A lopper (10) of the type having an anvil (22) cooperable with a blade (40) actuated by a pair of elongated members (12,14) made of moldable material, the first member (12) being unitary and comprising a first handle (18) merging into a first gear segment (20) having a central post (32) integral therewith, the first member (12) terminating at a distal end by the anvil (22), the second elongated member (14) comprising a second handle (24) merging into a second gear segment (26) at one end of the member, the second gear segment (26) having a second post (34) integral therewith, the first and second members (12,14) being pivotally connected to a metal plate (38) at the central and second posts. The moldable material is most preferably a plastic, but other moldable substances could be employed. <IMAGE>
Patent NO-970385-D0 (NO)
Inventor: LIOTTA DENNIS C
IPC: C07H19/06
Filed: 1997-01-29
Abstract: The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, ²-BCH-189 and related compounds. Furthermore, the stereochemistry at the nucleoside 4'-position can be controlled to produce enantiomerically-enriched ²-BCH-189 and its analogues.
Patent NO-971386-D0 (NO)
Inventor: RODUIT JEAN-PAUL
IPC: C07D241/24
Filed: 1997-03-24
Abstract: Production of amides of formula Q-CO-NR6R7 (I) comprises reacting Q-X with CO and HNR6R7 in the presence of a base and a palladium complex of a diphosphine of formula R8R9P(CH2)nPR10R11; Q = a 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl or 1,3,5-triazin-2-yl group with one C atom substituted by OR and the other C atoms optionally substituted by 1-4C alkyl or aryl; R = optionally substituted aryl or heteroaryl; X = Cl, Br or I; R6 = H or 1-4C alkyl; R7 = optionally substituted aryl or heteroaryl; R8-R11 = optionally substituted phenyl; n = 3 or 4. Also claimed is a process as above where Q-X is prepared by reacting Q'-X with ROH, where Q' = a 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl or 1,3,5-triazin-2-yl group with one C atom substituted by Cl, Br or I and the other C atoms optionally substituted by 1-4C alkyl or aryl.
Patent NO-973142-D0 (NO)
Inventor: HELLAND PER
IPC: A61B17/60
Filed: 1997-07-07
Abstract: The invention relates to a distraction apparatus for holding a fracture during the healing process. The apparatus includes screws or pins for insertion into a bone at points proximal and distal relative to a fracture site, and a pair of springs which can be connected externally between the screws or pins at spaced positions thereon. The springs act as an extension spring and a compression spring respectively between the screws or pins. The invention is characterized in that the springs are connected at the spaced positions at such distances relative to the bone that the springs will exert moments of force in order to obtain a desired torque load at the fracture site.
Patent NO-982249-D0 (NO)
Inventor: SCARBOROUGH ROBERT
IPC: C12N15/09
Filed: 1998-05-15
Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R<1>2 N(CH2)4CHNHCO- wherein each R<1> is independently H, alkyl(1-6C) or at most one R<1> is R<2>-C=NR<3> wherein R<2> is H, alkyl(1-6C), phenyl or benzyl, or is NR<4>2 in which each R<4> is independently H or alkyl(1-6C) and R<3> is H, alkyl(1-6C), phenyl or benzyl, or R<2>-C=NR<3> is a radical selected from the group consisting of: <CHEM> where m is an integer of 2-3, and each R<5> is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
Patent NO-983381-D0 (NO)
Inventor: LIED KJERSTI B
IPC: A47D5/00
Filed: 1998-07-22
Abstract: An adjustable supporting device for a premature infant, comprising an inflatable base (1) consisting of two superimposed air and gas impermeable layers (5, 6), divided into at least two flat sections (2, 3), and running along the perephery of the base an inflatable wall (4), optionally also divided into two sections, wherein all base sections (2, 3) and wall (4) or wall sections are inflatable and pressure-adjustable independent of one another.
Patent NO-983520-D0 (NO)
Inventor: YESAIR DAVID W
IPC: C12N9/16
Filed: 1998-07-31
Abstract: Methods for making lysophosphatidylcholine are provided, comprising hydrolysis of a mixture of phosphatidylcholine and an agent with phospholipase A2. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid.
Patent NO-983674-D0 (NO)
Inventor: ALBERTINI CARLO
IPC: G01N3/00
Filed: 1998-08-11
Abstract: FIGURE 2 shows compression wave generation apparatus 101 to the left of split Hopkinson pressure bar 102 including input bar 103 connected via test specimen 104 to output bar 105. Compression wave 106,107 is generated by initially placing impactor bar 109 under a pre-load force by hydraulic actuator 108 (in the direction of arrow A) until fragile component 110 ruptures causing end 109a to impact input end 103a of the input bar 103. End 109a is guided and held adjacent end 103a by collar 111 welded to end 109a prevented from movement to the left by blocking system 112. <IMAGE>
Patent NO-993343-D0 (NO)
Inventor: VALIENTE MANUEL MALMAGRO
IPC: A61K6/884
Filed: 1999-07-06
Abstract: Together with other accessory products, includes a mixture of ion-exchange resins, cationic and anionic, charged with Ca<2+>, F<-> and PO4<3-> ions, in an approximate molar ratio of 2:1:1, respectively. Particularly preferred is a material in which the resins also have a charge of Zn<2+> ions representing a proportion of less than 1%, preferably close to 0.2% of the dry weight of the resin. The preferred resins are those whose base is cross-linked polystyrene with 2-14% divinylbenzene. The material is useful as first filler in the treatment of caries, especially deep caries, leading to remineralization of the dentin with a composition very close to the original composition, together with high microhardness. It is also useful as a component of dentifrice products such as pastes, elixirs and dental floss.