Patent SG-11201907917X-A (SG)
Title: Pm21 particles to improve bone marrow homing of nk cells
Inventor: COPIK ALICJA
IPC: C12N5/00
Filed: 2018-02-28
Abstract: PMg/injection) PM21 (14/injection) .2 , 0,000 .50,000 Lung r, 60,000 .E 40,000 S 20 , 000 Liver o P=0.0003 o 0 0 o o 0 o° = —41 - o 0 0 o 0 800 0 800 PM21 (µg/injection) PM21 (µg/injection) 4;120% - P=0.012 ••\"100% +- 100% 80%-e 80% 60% _O R s . E 60% s ÷: 40%-o - o ( !1, 161 ig 40% 20 0% -1 30 % o 4tiSt 421t, 20%-g 0%- azt, sca, O 800 0 800 0 o ° o 0 P=0.035 00 1 -o P=0.015 0 120%- P=0.018 1 + -1oo: : '4 1 80% - LI g 40%- oo h o o c, 20% Eb?, 0% - e lm imok 0 800 PM21 (µg/injection) PM21 (vg/injection) PM21 (µg/injection) FIG. 5 - 100% 80% ' 4 ,2 - 60% '4, 40% • 20% 0% 0 0 otio PM21 (µg/injection) 80,000 460,000 .E 40,000 20,000 o Spleen Brain 0 0 800 PM21 (µg/injection) 0 800 PM21 (11g/injection) 120%- + 100% 80% a 60% • 40% c, 20% 0% D iz.xc 800 - 0 4E4 800 la 10,000 1 5,000 4 ' 000 f 2 •, 2,000 Bone marrow P=0.044 00 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT 011101010 0111 °nolo omiooliolioomll ono voimIE (10) International Publication Number WO 2018/160673 Al (51) International Patent Classification: A61K 35/17 (2015.01) Cl 2N 5/00 (2006.01) A61K 38/20 (2006.01) (21) International Application Number: PCT/US2018/020187 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,747 28 February 2017 (28.02.2017) US (71) Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 12201 Research Parkway, Ste 501, Orlando, Florida 32826 (US). RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL [US/US]; 700 Children's Dri- ve, Columbus, Ohio 43205 (US). (72) Inventors: COPIK, Alicia; 196 Paul McClure Ct., Cassel- berry, Florida 23707 (US). OYER, Jeremiah; 609 Albany Ct., Longwood, Florida 32779 (US). CHAKRAVARTI, Nitin; 2801 River Park Drive, Columbus, Ohio 43220 (US). LEE, Dean Anthony; 2561 Sitterly Road, Canal Winches- ter, Ohio 43110 (US). (74) Agent: LANIER, Gibson, J. et al.; Meunier Carlin & Curf- man LLC, 999 Peachtree Street, NE, Suite 1300, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS © (57) : Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles. C [Continued on next page] WO 2018/160673 Al MIDEDIMOMMIDIRE1013 0111 VIII 1101 INEHOMOVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))