Patent GB-1105987-A (GB)
Title: New azepine derivatives, processes for their production and compositions containingsame
IPC: C07D403/12
Filed: 1966-11-23
Abstract: Novel compounds of the general formula <FORM:1105987/C2/1> wherein X is an ethylene, propylene, vinylene or methylvinylene radical; Y1 is hydrogen, halogen, C1-C3 alkanoyl, alkyl or alkoxy or trifluoro-methyl; Y2 is hydrogen or the same halogen atom as Y1; Z is O or S; A1 is an ethylene, propylene or trimethylene radical; A2 is an alkylene radical having 2-5 carbon atoms in a straight or branched chain whereby the straight chain contains 2-4 carbon atoms; A3 is a vinylene radical or a direct bond and R1, R2 and R3 independently represent hydrogen or C1-C3 alkoxy groups; R1 can also represent a methylene dioxy group when R2 and R3 are hydrogen, and their addition salts with inorganic and organic acids are prepared by reacting a compound of the general formula <FORM:1105987/C2/2> with a reactive derivative of a carboxylic acid of the general formula <FORM:1105987/C2/3> or a reactive ester of an alcoholic compound of the above general formula is reacted with a salt of the above carboxylic acid; or a compound of the general formula <FORM:1105987/C2/4> may be reacted with a reactive ester of a compound of the general formula <FORM:1105987/C2/5> in the presence of an acid binding agent; or a halide of the general formula <FORM:1105987/C2/6> is reacted with a compound of the general formula <FORM:1105987/C2/7> or lastly compounds of the general formula <FORM:1105987/C2/8> are reacted with halides of the general formula <FORM:1105987/C2/9> where in Formulae VI and IX, Hal represents a chlorine or bromine atom.  Starting materials of the general Formulae II and IV are prepared by reacting a compound of the general Formula VI with a 1-(hydroxyalkyl) - piperazine, -2 - methyl - piperazine, -3 - methyl - piperazine or -hexahydro - 1H-1,4-diazepine or piperazine, 2-methyl-piperazine or hexahydro - 1H - 1,4 - diazepine.  Starting materials of the general Formula VII may be obtained by reacting reactive esters of compounds of the general Formula V with piperazine, 2-methyl-piperazine or homopiperazine. Halides of the general Formula IX are formed by the action of phosgene, thiophosgene or carbonic acid on compounds of general Formula VII or analogous compounds substituted in the 4-position of the piperazine or 1,4-diazepine ring by a methyl or benzyl group.  The starting material hexahydro - 1H - 1,4 - diazepine - 1 -ethanol is prepared by treating hexahydro-1H-1,4-diazepine with ethylene oxide in methanol and 1 - (2 - chloroethyl) - 4 - (5H - dibenz[b,f] azepine - 5 - carbonyl) - piperazine is prepared by treating the corresponding piperazinoethanol with thionyl chloride.  3,4,5-Trimethoxybenzoic acid-3-chloroproyl ester is prepared by treating 3 - chloro - 1 - propanol with 3,4,5-trimethoxybenzoyl chloride and potassium carbonate in benzene.  Pharmaceutical compositions contain as active ingredient compounds of the general Formula I or its non-toxic acid addition salts and at least one inert pharmaceutical carrier. Starches, cellulose derivatives or gelatines and lubricant may be used to form tablets or dragee cores which may be coated.  The compositions may be administered orally, rectally or parenterally and are stated to have an intense, protracted dilatory effect on the coronary vessels.