Patent SG-11201907922P-A (SG)
Title: Cd19 compositions and methods for immunotherapy
Inventor: SURI VIPIN
IPC: A61K38/17
Filed: 2018-03-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT ill~~~~~~~~ 011101010VIIIOH olo mu olo mum° oimIE (10) International Publication Number WO 2018/161017 Al (51) International Patent Classification: C07K 14/505 (2006.01) C07K 16/30 C07K 14/705 (2006.01) C07K 16/46 C07K 14/725 (2006.01) A61K 38/17 C07K 16/18 (2006.01) A61K 38/43 C07K 16/28 (2006.01) A61K 35/14 (21) International Application Number: PCT/US2018/020741 (22) International Filing Date: 02 March 2018 (02.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/466,601 03 March 2017 (03.03.2017) US 62/484,052 11 April 2017 (11.04.2017) US (71) Applicant: OBSIDIAN THERAPEUTICS, INC. [US/US]; 1030 Massachusetts Avenue, Fourth Floor, Cam- bridge, Massachusetts 02138 (US). = (72) Inventors: SURI, Vipin; 3 Coolidge Road, Belmont, Massachusetts 02478 (US). BRISKIN, Michael Joseph; 28 Harbell Street, Lexington, Massachusetts 02421 (US). DOLINSKI, Brian; 1030 Massachusetts Avenue, Fourth Floor, Cambridge, Massachusetts 02138 (US). ELPEK, Kutlu Goksu; 5 Florence Terrace, Arlington, Massachu- setts 02476 (US). LI, Dan Jun; 1030 Massachusetts Av- enue, Fourth Floor, Cambridge, Massachusetts 02138 (US). HELLER, Scott Francis; 559 Plain St., Stoughton, Mass- achusetts 02072 (US). OLS, Michelle Lynn; 65 Oak Av- enue, Northborough, Massachusetts 01532 (US). SUN, Dexue; 1030 Massachusetts Avenue, Fourth Floor, Cam- bridge, Massachusetts 02138 (US). KOSMIDER, Nicole; 1030 Massachusetts Avenue, Fourth Floor, Cambridge, Massachusetts 02138 (US). KULKARNI, Abhishek; 360 Tappan Street #3, Brookline, Massachusetts 02445 (US). BALAKRISHNAN, Vijaya; 142A Main Street, Groton, Massachusetts 01450 (US). EZELL, Tucker; 1030 Mass- achusetts Avenue, Fourth Floor, Cambridge, Massachusetts 02138 (US). (74) Agent: WARD, Donna, T. et al.; DT Ward, P.C., 142A Main Street, Groton, Massachusetts 01450 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (2006.01) (2006.01) (2006.01) (2006.01) (2015.01) — (54) Title: CD19 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY Figure 28A Unstimulated +11-2, no 1L-12 4E3 Unstimulated + IL-2 + 10Ong/ml 11-12 seD3/CD28 no IL-2, nolL-12 -ts sCD3/CD28 no 1L-2 100ng/mLIL-12 sCD3/CO28 + IL-2, no IL-12 -G sCD3ICD28 + 1L-2 + 10Ong/rnLIL-12 -o- Dynabeads +1L-2, no 1L-12 O Dynabeads + IL-2 + 100 /mit. IL-12 Day 111•1111K Stirn Cvtokines 1-1 (57) : The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Meth- C ods for inducing anti-cancer immune responses in a subject are also provided. [Continued on next page] WO 2018/161017 Al O II HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))