Patent SG-11201900422T-A (SG)
Title: Human lymphoid tissue-on-chip
Inventor: GOYAL GIRIJA
IPC: C12N5/07
Filed: 2017-07-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111 011101010111110111110100111111010111100111111111111110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/017605 Al 25 January 2018 (25.01.2018) W I P0 I P C T (51) International Patent Classification: (74) Agent: RESNICK, David, S. et al.; Nixon Peabody A61K 35/28 (2015.01) A61P 35/00 (2006.01) LLP, 70 W. Madison St., Suite 3500, Chicago, Illinois A61P 7/00 (2006.01) Cl 2N 5/07 (2010.01) 60602-4224 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/042657 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 18 July 2017 (18.07.2017) CA, DZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, MG, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/363,579 18 July 2016 (18.07.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/398,646 23 September 2016 (23.09.2016) US TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: PRESIDENT AND FELLOWS OF HAR- (84) Designated States (unless otherwise indicated, for every VARD COLLEGE [US/US]; 17 Quincy Street, Cam- kind of regional protection available): ARIPO (BW, GH, bridge, Massachusetts 02138 (US). GM, UG, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: GOYAL, Girija; 2 Chestnut St., Apt. 21, Cam-TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — bridge, Massachusetts 02139 (US). INGBER, Donald, E.; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 162 W. Canton St., Boston, Massachusetts 02118 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, — = (54) Title: HUMAN LYMPHOID TISSUE-ON-CHIP = = = 100 ( = = 112 104 110 102a = = = — 102b WIIII44,.\3 = 108 OP 0 / = pP , 102 108 I = = 114 1-1 ir) © FIG. I IN ,-1 © ---- (57) : An organ-on-a-chip microfluidic device is disclosed that mimics a human lymph node and/or human lymphoid tissue. GC ,_ 1 The device can include cells from human blood and lymphatic tissue, include an extracellular matrix for the development of immune 0 system components, and provide for the perfusion of fluids and solids resembling blood and lymphatic fluid within micrometer sized N channels. C [Continued on next page] WO 2018/017605 Al IMEDIMOM0101011MERI00 IIMOINIHINIMODEVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))