baber/WOPTO huggingface dataset:
Patent UA-56420-A (UA)
Title: Method of producing a protein stabilizer from pigskin and a set of equipment for heat treatment of the raw material
Inventor: BORODAI VALENTYNA DMYTRIVNA
Filed: 2002-04-12
Abstract: A method of producing a protein stabilizer from pigskin includes the subsequent raw material grinding up to finely destructed mass with the simultaneous in-flow heating, fat and moisture removal using a mechanical method, carrying out sterilizing and boiling soft the raw material. A unit of equipment for double dehydration and defatting, heat in-flow treatment of the raw material while producing the food protein stabilizer of pigskin contains a fine-destructing centrifugal machine with heating, a horizontal screw centrifuge, a screw press-extruder.
Patent UA-52519-A (UA)
Title: Method for bed processing
Inventor: Kovalko Mykhailo Petrovych
Filed: 2002-08-13
Abstract: Method for bed processing includes bringing in acid, surface active substance, oil, gas condensate of diesel fuel to the well. As acid bromide-hydrogen one is used, this is brought in as powder mix with activated coal. In the mix bromide-hydrogen acid and activated coal are used preliminarily mixed with obtaining gel mass, with drying at temperature 30°С and bringing to condition or bulk material.
Patent UA-58086-A (UA)
Title: Method for diagnosing critical ischemia of lower limb
Inventor: SUKHARIEV IVAN IVANOVYCH
Filed: 2002-09-27
Abstract: The method for diagnosing the critical ischemia of the lower limb consists in transcutaneous measurement of the partial pressure of the oxygen. Furthermore, the perfusion of the skin is measured employing laser dopplerometry, the reactive hyperemia test is performed and the ratio between the time required for attaining the maximal partial pressure of the oxygen and the time required for attaining the maximal perfusion of the tissues is calculated. The critical ischemia is diagnosed if this ration is less than 2.3.
Patent AP-1681-A (AP)
Title: Assaying method.
Inventor: COWAN GEORGE MICHAEL
IPC: G01N33/20
Filed: 2001-07-12
Granted: 2006-11-27
Abstract: The invention provides a method of assaying a mineral sample for determining the concentration of selected metals in a sample comprising the steps of providing a comminuted mineral sample; mixing such sample with a flux; preheating a reaction vessel to a temperature which approximates the melting point of the flux; introducing the mixture of the mineral sample and flux into the crucible, whereby the mixture is transformed to a molten state to capture the metal to be assayed in a collector material; and separating slag from the collector material.
Patent DO-P2006000270-A (DO)
Title: Method of generating energetic particles using nanotubes and articles thereof (métodos de generar partículas energéticas utilizando nanotubos y artículos de los mismos)
Inventor: COOPER CHRISTOPHER H
IPC: G21G1/00
Filed: 2006-12-05
Abstract: Se divulga un metodo de generar particulas energeticas, que comprende contactar nanotubos con una fuente de isotopos de hidrogeno, tal como D20, y aplicar energia de activation a los nanotubos. En una realization, los isotopos de hidrogeno comprenden protio, deuterio, tritio y combinaciones de los mismos. Tambien se divulga un metodo de transmutar materia que se basa en la probabilidad incrementada de una interaction nuclear de atomos confinados en las dimensiones limitadas de una estructura de nanotubos, que genera suficientes particulas energeticas para transmutar materia y exponer la misma a ser transmutada a estas particulas.
Patent DO-P2007000040-A (DO)
Title: Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas.
Inventor: BIOREC B V
IPC: A61K33/243
Filed: 2007-02-23
Abstract: La presente invención se relaciona con una combinación farmacéutica que incluye un inhibidor de la fosforilación de la Caseína Kinasa 2 (denominado P15) y los citostáticos usados en la quimioterapia del cáncer los cuales son administrados simultáneos, separados o secuencialmente. Los citostáticos preferidos son los platinos, taxanos, alcaloides de la Vinca, 5-fluorouracilo, doxorubicina, ciclofosfamida, etoposide, mitomicina C, imatinib, iressa y el velcade (vortezomib). La sinergia entre el péptido P15 y los compuestos químicos anticancerígenos, hace que la concentración eficaz de cada citostático en la combinación sea entre uno y dos órdenes de magnitud menor que la correspondiente a los citostaticos sólos. Consecuentemente, la combinación descrita en la invención tiene una toxicidad mucho menor que la reportada para los citostaticos anticancerígenos lo cual representa una ventaja crucial para su uso en el tratamiento del cáncer. Adicionalmente, la combinación administrada de manera secuencial produce la quimiosensibilización de tumores refractarios a los citostáticos mencionados mediante el pretratamiento con el péptido P15.
Patent DO-P2014000142-A (DO)
Title: Anillo vaginal que comprende meloxicam y un agente modulador de la liberación del principio activo, útil como anticonceptivo de uso continuo en mujeres
Inventor: CHEN SHU-CHEN
IPC: A61F6/06
Filed: 2014-06-18
Abstract: Anillo vaginal de liberación sostenida que comprende meloxicam y un agente modulador de la liberación del principio activo, tal como polivinilpirrolidona K-30, que libera el principio activo por al menos 90 días, útil como anticonceptivo de uso continuo en mujeres. El anillo vaginal comprende preferentemente 5% a 30% en peso de meloxicam, en relación al peso total de la formulación.
Patent DO-P2019000257-A (DO)
Title: Combinación farmacéutica que comprende ponesimod
Inventor: LAETITIA POUZOL
IPC: A61P37/06
Filed: 2019-10-08
Abstract: La presente invención se relaciona con una combinación farmacéutica que comprende un primer ingrediente activo que es ponesimod y un segundo ingrediente activo que se selecciona del grupo que consiste en teriflunomida y leflunomida.
Patent EC-SP10010145-A (EC)
Title: Uso de 3,11b-cis-dihidrotetrabenazina en el tratamiento de la esclerosis múltiple y la mielitis autoinmunitaria
Inventor: DUFFIELD ANDREW JOHN
IPC: A61K31/4745
Filed: 2010-04-29
Abstract: La invención estipula un compuesto para usar en el tratamiento de la esclerosis múltiple donde el compuesto es una 3, 11b-cis-dihidrotetrabenazina de fórmula (Ia): (Ia) o una de sus sales farmacéuticamente aceptables.
Patent EC-SP10010666-A (EC)
Title: Dronedarona para la prevención de la fibrilación auricular permanente
Inventor: GAUDIN CHRISTOPHE
Filed: 2010-12-08
Abstract: Uso de dronedarona para la preparación de un medicamento para uso en la prevención de la fibrilación auricular permanente.
Patent EC-SP11010812-A (EC)
Title: Complejo de mineral-aminoácido polisacárido
Inventor: RABOVSKY ALEXANDRE B
IPC: A23L33/15
Filed: 2011-02-07
Abstract: Este documento proporciona complejos que comprenden a un compuesto mineral-aminoácido y un polisacárido. Por ejemplo, el documento contiene composiciones que contienen tales complejos y métodos de fabricación y uso de tales complejos.
Patent EC-SP13012540-A (EC)
Title: Compuestos y composiciones novedosos para la inhibición de nampt
Inventor: REYNOLDS DOMINIC
IPC: C07D495/04
Filed: 2013-04-03
Abstract: La presente invención se refiere a compuestos y a composiciones para la inhibición de NAMPT, a sus síntesis, aplicaciones y antídotos. A continuación se muestra un compuesto ilustrativo de la invención.
Patent EE-200200036-A (EE)
Inventor: STEINMEYER ANDREAS
IPC: C07D333/22
Filed: 2000-07-24
Abstract: Vitamin D derivatives (I), having a cyclic substituent in the side-chain, are new. Also new are perhydroindane derivative intermediates (A) ands (B).  Vitamin D derivatives of formula (I), including all possible epimers, diastereomers and their mixtures, are new. Y1, Y2  =  H or -C(O)R5;  Y3 (in alpha- or beta-configuration)  =  H, OH, halo, OC(O)R5 or OR5;  R5  =  5-12C aromatic residue; or 1-12C optionally unsaturated alkyl (optionally interrupted by 1 or 2 O, 1 or 2 S and/or 1 or 2 NH; and optionally substituted by 1 or 2 OH, 1 or 2 NH2, 1 or 2 SH, 1 or 2 COOH and/or 1 or 2 COOH);  R1, R2  =  H or together form exocyclic =CH2;  R3, R4  =  H, F, Cl, Br or 1-4C alkyl;  or CR3R4  =  -C(=CH2)- or a 3-7 membered saturated or unsaturated carbocyclic ring;  Q  =  1-5C n-alkylene;  X1, X2  =  H, OH, OC(O)R5, F, Cl or Br (but not both OH or both -OC(O)R5);  or CX1X2  =  C=O;  Z'  =  carbocyclic or heterocyclic (including aromatic or heteroaromatic) ring system comprising a 5- or 6-membered ring optionally fused with a 6-membered ring (optionally substituted by one or more of each of halo, OH, COOR6 or 1-5C alkyl (itself optionally substituted by one or more of halo, 1-6C alkoxy and/or COOR6));  R6  =  1-6C alkyl, benzyl or phenyl. Independent claims are included for: (1) new perhydroindane derivative intermediates of formulae (A) and (B); (2) preparation of perhydroindane derivative intermediates of formula (XIIIa) by: (a) reacting a perhydroindane derivative of formula (A; T replaced by L) with protected, deprotonated propargyl alcohol to give (A; T = -CC-CH2OY5), (b) hydrogenating and deprotecting to give (A; T = -(CH2)3OH), (c) oxidizing to give (A; T = -CH2CH2CHO) and (d) reacting with a nucleophile Nu, cleaving Y4 and oxidizing the free OH group; and (3) preparation of vitamin D compounds of formula (IIa) by: (a) reacting a ketone of formula (XIIIb) with a trimethylsilyl acetoacetate ester in presence of a base or with a Wittig reagent in an aprotic solvent to give (B; U = COOR6), (b) reducing to give (B; U = CH2OH), (c) converting into (B; U replaced by L), (d) converting into the Wittig reagent (B; U = CH2P(O)(G)2) and (e) reacting with a ketone of formula (XXXIII) and optionally deprotecting the product.  T  =  -CC-CH2OY5, -(CH2)3OH or -CH2CH2CHO;  Y4  =  trialkylsilyl, mixed aryl-alkyl substituted silyl, tetrahydropyranyl or tetrahydrofuranyl protective group;  Y5  =  tetrahydropyranyl or benzyl;  E  =  side-chain, in which any keto and/or hydroxy groups are protected;  U  =  COOR6, CH2OH or CH2P(O)(G)2;  Y6  =  1-6C alkyl, benzyl or phenyl;  G  =  1-10C alkyl, 1-10C alkoxy, Ph or OPh;  L  =  leaving group;  Nu  =  nucleophile;  R7, R8  =  H or Me; or together form exocyclic =CH2 or a cyclopropane ring;  Y6  =  F, (CH2)nOH or (CH2)nOCOR5;  n  =  0-4;  Y'1  =  hydroxy-protecting group;  Y'3  =  H, halo or as Y'1.
Patent EE-200200469-A (EE)
Inventor: PARADISI GIANFRANCO
IPC: B01J20/281
Filed: 2001-01-22
Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC.  The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained from the process is particularly high, amounting to about 25.000 IU/mg.
Patent GB-189403640-A (GB)
Title: Apparatus for Removing Refuse from Vessels.
Inventor: MCDOUGALL ALEXANDER
Filed: 1894-02-20
Granted: 1895-02-16
Abstract: 3640. McDougall, A. Feb. 20. Ships'ashes, discharging.-The ashes are placed in a box B with grating C which may be Hooded with water through a pipe D with valve E. The mixture of ashes and water is delivered by a rotary pump through a pipe G into the sea. In a modification, the box B is fitted, to utilize space, below the hold floor A and the pump is placed in it. The driving-engine may be covered in.
Patent GB-189701669-A (GB)
Title: Improvements in and connected with Pneumatic Tyres for Bicycles, Tricycles, and other Road Vehicles.
Inventor: REEVES EDWARD AYEARST
Filed: 1897-01-21
Granted: 1897-12-24
Abstract: 1669. Reeves, E. A. Jan. 21. Wheels with aircompressing appliances; tyres, pneumatic.-Between the ordinary thickened air tube g and the rim z lies a second thin air tube i into which air can be drawn through the air filter k and valve m, and forced, by the compression of the tube i caused by the weight of the rider as the wheel revolves, along the tube i through the valve h and tube g<1> into the ordinary air tube g. The tube i may go only partly round the wheel, and may be replaced by two or more tubes. The air tube g is thickened and reinforced by bands of metal or. celluloid along the line of contact with the tube i.
Patent GB-189703198-A (GB)
Title: Improved Process for Making Bicycle Frames.
Inventor: WEGENER CARL
Filed: 1897-02-06
Granted: 1897-03-20
Abstract: 3198. Wegener, C. Feb. 6. Casting.-Bicycle frames are formed by casting the connecting lugs or pieces on to the ends of the tubes. The ends of the tubes c, c<1> are increased in thickness, and inserted in suitably-shaped moulds a, provided with cores b<1>. Molten metal is run through the moulds by means of inlet and outlet tubes d, until the ends of the tubes are fused to form a part of the lug being cast. Fig. 1 s how s a mould for casting the steering-socket. Moulds for casting bottom brackets, fork ends, and seat pillar lugs are also shown.
Patent GB-189707294-A (GB)
Title: Improved Water Meter.
Inventor: GUILBAUD AUGUSTE
Filed: 1897-03-20
Granted: 1898-02-19
Abstract: 7294. Guilbaud, A. March 20. Liquid meters.- The meter is fitted to the water pipe, and consists of a hollow cylinder E rotated by the water passing through an internal screw. The rotations actuate index mechanism in the casing O. A narrow pipe b drains this casing to the delivery pipe.
Patent GB-189711376-A (GB)
Title: An Improvement in Adjustable Baby Chairs and other Rocking Chairs.
Inventor: MCPHUN JOHN POLLOCK
Filed: 1897-05-07
Granted: 1898-03-05
Abstract: 11,376. McPhun, J. P. May 7. Chairs.-Frames B, B' fixed to the underside of an ordinary nursery chair are connected to the ordinary frame C by a pair of links D pivoted at d, d'. The dotted positions show how the chair locks or swings. To lock the chair in a fixed position, a catch F pivoted to the frame C drops into a slot E in the frame B<1>.
Patent GB-189714868-A (GB)
Title: Improvements in the Treatment of Rhea Grass and Fibrous Plants, and in Apparatus therefor.
Inventor: MACDONALD JOHN MALCOLM
Filed: 1897-06-19
Granted: 1898-06-18
Abstract: 14,868. Macdonald, J. M., and Boyle, H. H. June 19. Retting; processes.-Rhea &c. is boiled first in a stronger and afterwards in a weaker solution containing hydrate of soda and silicate of soda, and steeped successively in solutions of permanganate of potash, a mixture of hyposulphite of soda and hydrochloric acid, hydrochloric acid alone, and a solution containing olive oil and soap. After each of the above operations the material is washed, and is finally passed through squeezing- rollers and dried. The apparatus comprises a series of tanks, which may be duplicated, with washing-tables between, and a set of squeezing- rollers at one end. The liquid in the first two tanks is boiled by steam or other suitable means, and the remaining tanks are at the ordinary temperature. Fig. 3 shows a pair of tanks C<2>, C<3>. They are fitted with perforated false bottoms G, below which the liquid is admitted from an elevated reservoir A, the excess of liquid overflowing into a gutter G<1> which communicates with a tank G<2>, from which the liquid is forced by a pump G<3> back into the tank A. The material is placed in a cage F, and raised and lowered as required by means of an overhead carrier H.
Patent GB-189714978-A (GB)
Title: Improvements in Machines for Washing Bottles and the like.
Inventor: DONALLY MELVIN
Filed: 1897-06-21
Granted: 1897-07-31
Abstract: 14,978. Donally, M. June 21. Cleaning bottles, jars. &c. -Relates to a machine for cleaning bottles, jars, and the like in which the bottles &c. are partly filled with shot and water and are agitated in a suitable holder. Fig. 1 shows a side view. The bottles are placed in a rotating carrier J, where they are held by spring- pressed caps h<1>. Water from the flexible hose k<1> and shot from the holders k<7> are run into the bottles. The carrier J is supported in the frame E, which receives a reciprocating motion from connecting- rods b<2> attached to eccentrics B<1> at each side of the machine. As the frame E moves to and fro, studs on the wheel G<1> meet arms g<1>, g<2> on the side frame A, which cause the wheel G<1> to rotate and with it the carrier J. Suitable means are described for controlling the machinery and the water supply.
Patent GB-189715204-A (GB)
Title: Improvements in Stockings and Socks.
Inventor: LINDEMUTH GOTTHARD
Filed: 1897-06-25
Granted: 1897-08-07
Abstract: 15,204. Lindemuth, G. June 25. Stockings a n d socks are made up of two stockings or socks E, F, one within the other, each being knitted independently, and connected together in parts and to an upper band A.
Patent GB-189721281-A (GB)
Title: An Improved Tool for Holding and Guiding Nails during the Insertion of the same into any Material.
Inventor: HUSTEDT CARL
Filed: 1897-09-16
Granted: 1897-10-16
Abstract: 21,281. Hustedt, C. Sept. 16. Nailing, hand tools for; pliers.-The tools are for holding nails while they are being driven in the manufacture of boxes &c. Two levers A, B are pivoted at C and pressed apart by a spring F. The nails are held in notches f, the lines g serving to determine their position in the work accurately.
Patent GB-189725178-A (GB)
Title: Improvements in Navigational Sounding Machines.
Inventor: LARGS WILLIAM THOMSON BARON KE
Filed: 1897-10-30
Granted: 1898-09-03
Abstract: 25,178. Kelvin of Largs, W. Thomson, Baron. Oct. 30. Sounding-apparatus. - Relates to improvements in the machine described in Specications No. 5675, A.D. 1883, and No. 12,240, A.D. 1885. The winch D runs freely on its spindle B, the plate d<1> carrying a tubular collar lined with lignum vitae, and is controlled when the line is running out by lignum-vitµ rubbing-pieces e, e, f, f, the former carried by a plate E fixed to the spindle, and the latter by a plate F working on a screw b on the spindle. These rubbing - pieces are pressed against the winch by springs H regulated by nuts I. When it is desired to clutch the winch to its spindle, a catch G is engaged with one of a series of teeth f<1> on the plate F so as to prevent the latter from turning. If the spindle B be now turned in the right direction, the plate F will move to the right and the winch be jammed against the plate E so as to couple it. The sounder, Fig. 5. has a piston N working practically water - tight in a tube M against the action of a spring O. A projection o moves the spring pointer P in a graduated slot in the casing while the pressure is increasing, leaving it held at the maximum point by its spring grip on the edges of the slot when the instrument is being drawn up. m is a stop to prevent the piston N from rising further than is intended in extreme depths. A screw valve Q is provided for emptying out any water that may force its way past the piston.
Patent GB-189730073-A (GB)
Title: Improvements in Friction Clutches for Transmitting Rotary Motion.
Inventor: MACKENZIE HUGH WATSON
Filed: 1897-12-20
Granted: 1898-10-22
Abstract: 30,073. Mackenzie, H. W., and Robertson, A. O. Dec. 20. Clutches.-A ring n, fixed to one member b of the clutch, is placed between the flange e and an internally threaded ring j upon the screwed body of the other clutch member d. The ring is rotated, to clamp the ring n, by means of the hand-lever s and a ring k formed with two sets of inclined slots, one set to engage pins l on a ring f, fixed upon the part d, and the other the pins m on the ring j. Copper rings o, p are placed at the sides of the ring n. In a modification, the ring k is moved by a rack and pinion.
Patent GB-189806098-A (GB)
Title: Improved Machine for Boring Rock, Dressing and Breaking Stone, Riveting and for other like Purposes.
Inventor: CATTANACH ALEXANDER
Filed: 1898-03-12
Granted: 1899-03-11
Abstract: 6098. Cattanach, A. March 12. Mills and apparatus. -Relates to machines applicable for boring rock, dressing and breaking stone, riveting, &c. Fig. 1 shows a form of machine adapted for boring rock. The jumper or drill H is struck by a hammer d mounted in a pivoted frame C and operated by links f from treadles or crank gear. A saddle G may be attached to the framework. The hammer is adjustably mounted in the frame C by a screw and hand-wheel k, to allow for variations in height of the drill, or this adjustment may be made automatic by ratchet gear. A pick or dressing-tool may be substituted for the hammer head, and the frame &c. may be modified to suit the various purposes mentioned.
Patent GB-189807909-A (GB)
Title: Improvements in the Construction and Principles of Sterilizers for Surgical Instruments, Surgical Dressings, Milk, and other articles.
Inventor: WHITE GEORGE BURBIDGE
Filed: 1898-04-02
Granted: 1899-04-01
Abstract: 7909. White, G. B. April 2. Disinfecting.-Relates to apparatus for sterilizing surgical instruments and dressings, milk, &c. The article &c. to be sterilized is placed in a chamber B which rests on a grating P in a tube A as shown. The space between the grating P and a partition W in the tube A contains water which is heated by means of a lamp G so as to envelope the chamber B in a steam jacket. The chamber is closed at its upper end by a plug consisting of flax, wool, hair, &c. which allows steam &c. to enter, but, owing to the pressure on its outer side, prevents condensed moisture from escaping. A thermometer T, inserted in a tube T<1> which passes through the plug T, indicates the temperature. The tube A may be closed by a suitably-perforated cap L.
Patent GB-189808909-A (GB)
Title: Improvements in Coats and like Garments.
Inventor: YOUNG DAVID
Filed: 1898-04-16
Granted: 1899-02-18
Abstract: 8909. Young, D., [Chisholm, J.]. April 16. Coats and jackets waterproof coats; collars.- Relates to the collars of coats and other garments, and particularly to the collars of waterproof coats, and consists in attaching the collar to the garment by means of the piece of fabric C, Fig. 1, shaped as shown. This piece C is sewn to the collar B as shown in Fig. 4, and is then sewn or cemented into the garment A, Fig. 5, to which also the ends of the collar B are sewn or cemented.
Patent GB-189810499-A (GB)
Title: Improvements in or connected with Battens for Weaving Looms.
Inventor: POYSER JOHN
Filed: 1898-05-07
Granted: 1899-01-07
Abstract: 10,499. Poyser, J. May 7. Loom lays; reeds; beat-up motions.-Relates to improvements whereby the spring used with the battens and described in Specification No. 144, A.D. 1895, is dispensed with. In one arrangement, shown in Fig. 2, two cams c and i directly operate the two parts a and e of the batten, respectively, the two cams being so arranged that the part e of the batten remains at rest until the other part a moves up to it, both parts then moving together to beat up the weft, and then the part e coming to rest before the part a, which continues to move back to separate the two parts of the batten. In another arrangement, shown in Figs. 6 and 5, the part a of the batten is driven by a cam, the part e of the batten being driven by the part a through the medium of a connecting-piece m, slots k, l being formed in the parts a and e of the batten respectively and the connecting-piece m pivoted to the machine supporting a pin n bearing rollers in the slots k, l respectively.
Patent GB-189811420-A (GB)
Title: Improvements in the Preparation of Argentiferous Sensitive Surfaces for Photographic Purposes.
Inventor: MERCIER PIERRE
Filed: 1898-05-19
Granted: 1899-04-29
Abstract: 11,420. Mercier, P. May 19. Sensitized plates and films; developing.-Relates to the preparation and treatment of plates and films to render them capable of standing over-exposure. The plates are treated before or after exposure with solutions of antimonial salts, or morphia, codein, or the like, and then developed, preferably with hydroquinone. Developing-substances such as amidol, hydroquinone, &c. may be used for the same purpose. These substances may be mixed with the emulsion in the preparation of the plates, and are kept in their normal unoxidized condition by the addition of a little acid or alkali.