baber/WOPTO huggingface dataset:
Patent CR-20110471-A (CR)
Title: Proteínas de unión específicas y sus usos
Inventor: OLD LLOYD J
IPC: A61K39/395
Filed: 2011-09-01
Abstract: Proteínas de unión a IL-17 y/o IL-17F, su uso en composiciones y métodos para el tratamiento, prevención, y diagnóstico de enfermedades relacionadas con IL-17 y para detectar IL-17 en células, tejidos, muestras y composiciones.
Patent CR-20120415-A (CR)
Title: Polipéptidos agonistas que se enlazan a dr5
Inventor: CROMIE KAREN
IPC: A61K39/395
Filed: 2012-08-10
Abstract: La presente invención se refiere a las secuencias de aminoácidos que se dirigen contra el receptor de superficie celular 2 de TRAIL (en la presente también "DR5"), así como a los compuestos o construcciones de las mismas, y en particular a las proteínas y los polipéptidos y los nucleótidos que las codifican (referidos en la presente en su totalidad como "agentes NB"), y a los fragmentos de las mismas, y a las variantes farmacéuticamente efectivas de las mismas, y a su uso en el diagnóstico y el tratamiento de las enfermedades y los trastornos asociados con el DR5.
Patent CR-20130387-A (CR)
Title: Caja
Inventor: ORGELDINGER WOLFGANG
IPC: B65D6/18
Filed: 2013-08-09
Abstract: Una caja abarca un fondo (10) y por lo menos dos pares de paredes laterales opuestas entre sí que se extienden desde el fondo (10) en dirección vertical hacia arriba. Las paredes laterales están dispuestas de manera rebatible con respecto al fondo (10), y en su posición desplegada pueden bloquearse entre sí. Por lo menos una de las paredes laterales (12) abarca un mecanismo de desbloqueo (38), que puede moverse entre una posición de descanso y una posición de desbloqueo en la que el bloqueo (28, 30) de las paredes laterales está anulado.
Patent CR-20140549-A (CR)
Title: Formas cristalinas de un modulador del receptor androgénico
Inventor: SMITH NICHOLAS D
IPC: C07D401/04
Filed: 2014-12-01
Abstract: En la presente descripción se describe formas amorfas y cristalinas del modulador del receptor androgénico 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaspiro[3.4]oct-5-il]-2-fluoro-N-metilbenzamida.
Patent CR-20150106-A (CR)
Title: Solución nbpt para la preparación de inhibidor de ureasa para fertilizantes de urea a base de amino alcoholes n-alquil; n, n-alquil; y n-alquil-n-alcoxi
Inventor: WHITEHURST BROOKS
IPC: C05G3/90
Filed: 2015-02-27
Abstract: Se preparan soluciones al disolver Triamida N-(n-butil) tiofosfórica (NBPT) en uno o más N-alquil amino alcoholes, N, N-dialquil amino alcoholes, N-alquil-N-alcoxi amino alcoholes, y una mezcla de los mismos. Las soluciones pueden utilizarse en fertilizantes de urea para reducir la volatilización del nitrógeno, o para reducir los olores de desechos animales. También se describen métodos para preparar fertilizantes de urea y los productos que resulten de estos métodos.
Patent CR-20150107-A (CR)
Title: Métodos para el tratamiento de infecciones de hepatitis b y hepatitis d
Inventor: BAZINET MICHEL
IPC: A61P31/14
Filed: 2015-02-27
Abstract: Se describe un método para el tratamiento de la infección por HBV o de la coinfección por HBV/HDV, el cual método comprende la administración a un sujeto que necesita el tratamiento de un primer agente farmacéuticamente aceptable que retira el antígeno de superficie de hepatitis B de la sangre y un segundo agente farmacéuticamente aceptable que estimula la función inmunitaria.
Patent CR-20230402-A (CR)
Title: Pharmaceutical combinations of sos1 inhibitors for treating and/or preventing cancer
Inventor: KAMBOJ RAJENDER KUMAR
IPC: A61K31/337
Filed: 2022-01-19
Abstract: This disclosure relates to pharmaceutical combinations for treating and/or preventing cancer and methods and uses thereof. More particularly, provided is a pharmaceutical combination comprising a SOS1 Inhibitor and an additional active ingredient selected from a KRAS inhibitor such as a KRAS G12C inhibitor and a KRAS G12D inhibitor, KRAS G13C inhibitor, and pan KRAS inhibitor; an EGFR inhibitor; an ERK1/2 inhibitor; a BRAF inhibitor; a pan-RAF inhibitor; a MEK inhibitor; a AKT inhibitor; a SHP2 inhibitor; protein arginine methyltransferases (PRMTs) inhibitor such as a PRMTS inhibitor and Type 1 PRMT inhibitor; a PI3K inhibitor; a cyclin -dependent kinase (CDK) inhibitor such as CDK4/6 inhibitor; a FGFR inhibitor; a c-Met inhibitor; a RTK inhibitor; a non-receptor tyrosine kinase inhibitor; a histone methyltransferases (HMTs) inhibitor; a DNA methyltransferases (DNMTs) inhibitor; a Focal Adhesion Kinase (FAK) inhibitor; a Bcr-Abl tyrosine kinase inhibitor; a mTOR inhibitor; a PD1 inhibitor; a PD-L1 inhibitor; CTLA4 inhibitor; and chemotherapeutic agents such as gemcitabine, doxorubicin, cisplatin, carboplatin, paclitaxel, docetaxel, topotecan, irinotecan and temozolomide.
Patent EC-SP003763-A (EC)
Title: Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
Inventor: HESTER JACKSON B
IPC: A61K31/42
Filed: 2000-11-13
Abstract: La presente invención provee un compuesto de la fórmula I Que tiene potente actividad contra las bacterias grampositivas y gramnegativas.
Patent EC-SP034771-A (EC)
Title: Dispositivo automatico-manual para controlar la salida de agua y cualquier fluido; de funcionamiento mecanico y de facil instalacion
Inventor: SOSA RAFAEL
IPC: F16K21/18
Filed: 2003-09-16
Abstract: La presente invención se refiere a un dispositivo automático-manual para controlar la salida de agua y cualquier fluido; de funcionamiento mecánico y fácil instalación. El cual presenta una boquilla de admisión roscable de entrada de agua y cualquier fluido, la cual puede ser girada direccional dicho dispositivo según convenga, también consta en su interior de dos imanes con polaridad inversa, un resorte, dos membranas de hule con orificios, una membrana de hule sin orificio, dos soportes para dichas membranas, una cámara de aire, un anillo de metal accionado a voluntad, un mecanismo de funcionamiento con las siguientes posiciones: no - off, un tubo doble de cobre que se sumerge en el recipiente a llenar, una manguera de hule que conecta el tubo doble de cobre con la cámara de aire, un mecanismo de accionamiento en las posiciones manual y automático para el funcionamientote dicho dispositivo. El funcionamiento de la presente invención es provisto y tiene por objeto si cerrar el paso de agua y cualquier fluido al estar lleno el recipiente, cisterna, pila, tonel, tina, bañera, inodoro, piscina y otros depósitos por medio de la presión hidrostática que ejerce el mismo deposito de agua por medio del tubo de cobre conectada por la mangueras de hule a la cámara de aire que ejerce la presión necesaria para separar los imanes y así cerrar el orificio de paso del fluido.
Patent EC-SP034880-A (EC)
Title: Dispositivo de control hidráulico
Inventor: BATEMAN IAN ROGER
IPC: F16L55/165
Filed: 2003-12-08
Abstract: Un dispositivo de control hidráulico (66) en conjunto con una máquina de renovación del revestimiento interno de tubos (1,2), que incluye líneas de suministro de presión de fluido y de retorno (4,5), un controlador de motor (80) para controlar a un motor (67) y un controlador de posición radial. El controlador de posición radial provee fluido bajo presión a una instalación de posicionamiento radial (46) para establecer el diámetro de un tubo reacondicionado. El controlador de posición radial tiene una primera válvula normalmente cerrada (83) que provee fluido bajo presión a la instalación de posicionamiento radial y una segunda válvula normalmente abierta (84) que permite que el fluido sea extraído desde la instalación de posicionamiento radial. La instalación permite que la máquina de renovación del revestimiento interno de tubos sea extraída en la eventualidad de una falla.
Patent EC-SP045159-A (EC)
Title: "antagonistas nk1"
Inventor: PALANI ANANDAN
IPC: A61K31/437
Filed: 2004-06-17
Abstract: Un antagonista NK, que posee la fórmula (I) donde Ar1 Ar2 son fenilo ó heteroarilo opcionalmente sustituidos, X1 es una unión éter, tio ó imino, R4 y R5 no son H ni alquilo, y las variables restantes son según se las definió en la especificación, útil para tratar una cantidad de trastornos, incluyendo emesis, depresión, ansiedad, y tos. Composiciones farmacéuticas. También se detallan los métodos de tratamiento y combinaciones con otros agentes.
Patent EC-SP992826-A (EC)
Title: Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
Inventor: HERBERT JEAN-MARC
IPC: C08B37/00
Filed: 1999-01-13
Abstract: La presente invención se refiere a polisacáridos de sintesis en forma ácida y sus sales farmacéuticamente aceptables, cuya forma amiónica responde a una de las fórmulas (I) a (V) definidas en la reinvindicación 1. Esos polisacáridos son utilizables en el tratamiento de patologias dependientes de una disfución de la coagulación.
Patent FI-20075368-A (FI)
Inventor: LINDEN OLAVI
IPC: A01G3/025
Filed: 2007-05-22
Abstract: The invention relates to pruning shears comprising a cutting head (12) with a spring-loaded blade (18) acting in cooperation with a counter blade (20), a drive mechanism (16) connected to the cutting head (12), and an elongated handle (14) connected to the drive mechanism (16). The drive mechanism comprises a first and a second counterpart (32, 34), optionally rotating with respect to one another about an axis (36), allowing the cutting head (12) to be adjusted with respect to the elongated handle (14), and an upper line arrangement allowing the blade (18) to be turned about a hinge point (19) and the cutting head to be adjusted in such a manner that the blade (18) does not rotate about the hinge point (19).
Patent FR-1601680-A (FR)
Title: Automatic fruit piercer for syrup penetra- - tion in crystallised fruits manufacture
IPC: A23B7/08
Filed: 1968-12-23
Granted: 1970-09-07
Abstract: Fruit passing through an inclined chamber is stabbed by reciprocating multiple needles driven in from opposite sides simultaneously. Specifically the needles may be carried in crossheads reciprocated by connecting rods from an opposed-arm rocker pivoted on the side of the chamber. The rocker in turn is oscillated by a connecting rod from a continuously rotated crank. The needles may be of stainless steel and spring-loaded within tubes screwed into the cross-heads.
Patent FR-1604161-A (FR)
IPC: B60R19/44
Filed: 1968-08-27
Granted: 1971-07-26
Abstract: 1,244,660. Vehicle bumpers. PEBRA G.m.b.H. PAUL BRAUN. 22 Aug., 1968 [1 Sept., 1967], No. 40300/68. Heading B7J. A decorative and protective fender for a vehicle body comprises an elongated metal rail 1 of channel cross-section adapted to be fitted to the vehicle body with the mouth of the channel opening towards the body, the rail having a longitudinal groove 3 of dove-tail cross-section formed in its base portion to open outwardly of the vehicle body in which groove is anchored an edge portion 4 of a resilient member 2 of rubber or flexible plastics, the member 2 extending from the edge portion 4 around the side of the metal rail that is lower in use and across the mouth of the channel. A projecting fillet 8 of member 2 embraces the lower one, in use, of a pair of substantially coplanar flanges 6, 7 formed on the longitudinal side walls of the metal rail, and extending across the mouth of the channel, and a bulge 9 on member 2 adjacent the edge portion 4 gives added protection against impact. An end cap extends obliquely across each end of the protective rail and is formed of a plate 10 shaped to correspond with the shape of the end of the rail and having flanges 11 and 12 and a rib 13 for engaging the interior of the metal rail 1. Part of the rail is cut away to accommodate the flange 11.
Patent GB-1051560-A (GB)
Abstract: 1,051,560. Calculating apparatus. F. W. RUIJS. April 20, 1964 [April 24, 1963], No. 16214/64. Heading G4B. In a setting means for a ten-key calculating machine or the like, a single gear rack mechanism serves all ten keys. Depression of a key 32 couples a shaft 10 to a continuously running motor 9 to move a gear rack 4 or 5 a distance determined by a series of plates 35 with slots 35a of depth dependent on the key depressed and then returns the gear rack to its initial position. The gear rack 4 or 5 operates a pinion 1 to rotate setting and total wheels 36, 37. The key 32 has a nose 33 for co-operating with either rod 29 or 31 such that a link 27 may be raised or lowered to permit engagement of one of pins 22, 23 in a slot in a plate 29 and hence engagement of pinion 1 with one of gear racks 4, 5. A wedge 34 on the key stem 32 moves the plates 35 to the left or right to provide a slot of the appropriate depth. Release of a finger 41 by a hook 42 permits a spring 39 to couple member 38 to 44 and the motor 9. Rotation of the shaft 10 causes finger 41 to contact an extension 47 and the coupling 38, 44 is disengaged. During the first half revolution the rack frame 6 is moved up or down to contact the pinion 1 and then laterally by a spring 14 until a projection 16 is stopped by a plate 35. During the second half revolution the gear rack 6 is brought into a free position and returned by a cam 11.
Patent GB-1227428-A (GB)
IPC: C07F7/18
Filed: 1968-04-08
Abstract: 1,227,428. Organo-siloxy-cyano compounds. INSTITUT FUR SILIKON UND FLUORKARBON-CHEMIE. 8 April, 1968, No. 16748/68. Heading C3S. Organo-siloxy-cyano compounds of the general formulµ where n is 1 or 2, R is alkyl, alkenyl or aryl, R and R<SP>11</SP> are hydrogen or unsubstituted or substituted alkyl, alkenyl, aryl, alkaryl, aralkyl or cycloalkyl or together with the carbon atom to which they are attached form an aliphatic ring, X is a direct bond or an alkylene, arylene or alkenylene radical and C<SP>1</SP> and C<SP>2</SP> can be parts of an aliphatic ring system, are prepared by reacting a cyanosilane R 4-n Si(CN) n , with a carbonyl compound R<SP>1</SP>COR<SP>11</SP> or a dicarbonyl compound R<SP>1</SP>C<SP>1</SP>(O )XC<SP>2</SP>(O)R<SP>11</SP> respectively. Compounds of Formula I in which R<SP>1</SP> and R<SP>11</SP> are not both methyl and the compounds of Formula II are novel.
Patent GB-1228066-A (GB)
IPC: G01N30/96
Filed: 1969-03-31
Abstract: 1,228,066. Agarose derivatives. INSTITUTUL DE BIOCHIMIE AL ACADEMIEI RSR. 31 March, 1969 [30 March, 1968, No. 16705/69. Heading C3U. Novel triethylaminoethyl derivatives of agarose, or of agarose cross-linked with glyceric bridges, are prepared by treating the corresponding diethylaminoethyl derivatives with a boiling ethanolic medium containing ethyl bromide.
Patent GB-1230207-A (GB)
IPC: D01D4/08
Filed: 1968-11-14
Abstract: 1,230,207. Detachable melt-spinning nozzle assemblies. ERSTE MASCHINENFABRIK KARL MARX STADT. VEB. 14 Nov., 1968, No. 54015/68. Heading B5B. A device for facilitating the insertion and withdrawal of spinning nozzle assemblies in melt-spinning apparatus as shown in the drawing (which represents a cross-section of the spinning beam of a melt-spinning apparatus) comprises a lever 4 which is provided with a recess to accommodate a spinning nozzle assembly 7 and can be inserted in the recess 2 of the spinning beam 1. The recess 2 is delimited at the bottom by a plate 3 which at the same time provides a sliding surface when the lever 4 is being inserted in or withdrawn from the recess 2. To define the distance which the lever 4 carrying the assembly 7 must be inserted in the recess 2 a transverse pin or bar 8 is fixedly mounted on the plate 3 at the inner end of the aperture 2 and functions as a combined stop and fulcrum of the lever 4. A vertical guide pin 9 is fixedly mounted in the transverse bar 8 and is a close sliding fit in an open-ended slot at the inner end of the lever 4. It thus serves as a means by which the spinneret assembly 7 is guided into its operative position underneath the outlet of the melt feed duct 10 of the spinning beam 1. A bolt 5 pivotally mounted on the beam 1 and provided with a nut 6, serves to enable the inlet of the polymer melt duct in the spinneret assembly 7 accommodated by lever 4 to be urged against and into liquid-tight engagement with the outlet and of the feed duct 10. To connect the swing bolt 5 with the lever 4 the latter is provided with a fork-shaped recess at the end which projects from the recess 2. The melt inlet of the spinneret assembly 7 is provided with a sealing ring 11 and its lateral bearing surfaces of the assembly are cambered in order to ensure that the plane of the sealing ring 11 is parallel and in alignment with the outlet of the feed duct 10. Alternatively, the walls of the recess in the arm 4 in which the assembly 7 is located may be cambered, the walls of the assembly being straight. The plate 3 is provided with an aperture 12 through which the melt spun filaments can travel. In order to insert the spinneret assembly 7 into its operating position in the recess 2, the assembly 7 is inserted into its seat in the lever 4 and the lever 4 inserted lengthwise in the recess 2 by sliding it over the plate 3 until it engages the transverse bar or pin. The swing bolt 5 is then guided into the forked outer end of the lever 4 and the melt inlet of the assembly 7 with its sealing ring forced into liquid tight engagement against the outlet of the feed duct 10.
Patent GB-1231346-A (GB)
IPC: B23H1/02
Filed: 1969-05-27
Abstract: 1,231,346. Spark-erosion. MITSUBISHI DENKI K.K. 27 May, 1969 [27 May, 1968], No. 26643/69. Heading B3V. [Also in Division H2] Undesirable arcing between the electrodes of an electro-erosion machine is ascertained by detecting the absence of a voltage across the gap higher than the arc voltage within a predetermined reference time. In one embodiment, during normal operation a Zener diode 46 is conductive when a high no-load voltage portion 62 of each pulse 60 occurs across the gap 16-18. A transistor 48 is triggered by the diode 46 causing a capacitor 50, charged from a source 54, to be short circuited. The diode 46 is non- conductive during a lower arc voltage portion 64 of each pulse 60 and during each pause period T 2  so that the capacitor 50 continues to be charged. If a no-load voltage portion 62 of each pulse 60 has not occurred by the time the capacitor 50 has been charged to voltage E 0 , a device 56 is operated to stop the pulse generator 40 or to operate an electrode feed mechanism. The time taken for the capacitor 50 to be charged to voltage Eg is equivalent to at least 10 pulses. The protective circuit may be used in conjunction with a capacitor discharge electro-erosion machine (Fig. 1, not shown).
Patent GB-1234471-A (GB)
IPC: C25D3/66
Filed: 1968-06-11
Abstract: 1,234,471. Lithiding metal compositions. GENERAL ELECTRIC CO. June 11, 1968 [July 3, 1967 No.27656/68. Heading C7B. A method of forming a lithide coating on a metal composition, the metal composition having a melting point of at least 600 C., at least 1 mole per cent of said metal composition being a metal in which lithium is soluble, which method comprises (1) forming an electric cell containing said metal composition as the cathode, joined through an external electrical circuit to a carbon or lithium anode, and a fused salt electrolyte composed of a member of the class consisting of lithium fluoride, mixtures thereof with one or more of the remaining alkali metal fluorides and mixtures of lithium fluoride with one or more of the alkaline earth metal fluorides, said electrolyte being in the substantial absence of oxygen and being maintained at a temperature of at least 500 C. but below the melting point of said metal composition, (2) optionally applying e.m.f. not exceeding 1À0 volt to the cell from a source external to the cell when using a lithium anode and essentially applying e.m.f. not exceeding 4À0 volts from such external source when using a carbon anode; and (3) the current flowing in said electric cell being such that the current density of the cathode does not exceed 10 amperes/dm<SP>2</SP> during the formation of the lithide coating. The term "lithide" designates any solid solution or alloy or intermetallic compound of Li. The metal composition which is lithided may be Cr, Co, Ni, Cu, Fe, Mn, Pd, Ag, Pt, Au or alloys of these metals which each other or alloys containing at least 1 mole per cent of these metals. The electrolyte may be pure LiF or the following eutectic mixtures (i) LiF, NaF, (ii) LiF, KF or (iii) LiF, NaF, KF. By "substantial absence of oxygen" it is meant that neither atmospheric oxygen nor oxides of metals are present in the fused salt bath. Reagent grade salts may be used under vacuum or in an atmosphere of N 2 , Ar, He, Ne, Kr or Xe. Prior to the lithiding, the reagent grade salts may be purified electrolytically. When using a Li metal anode, it is in liquid form and is contained on the surface of the fused salt bath by a tubular container. When using a carbon anode, tetrafluoromethane is produced as a by-product at the anode.
Patent GB-1251433-A (GB)
IPC: C08B31/00
Filed: 1969-01-14
Abstract: 1,251,433. Determination of endohydrolases. PHARMACIA A.B. 14 Jan., 1969 [15 Jan., 1968], No. 2109/69. Heading B1X. [Also in Division C3] A method for determining endohydrolases capable of hydrolysing polysaccharides, in aqueous samples, comprises contacting the sample with a water-insoluble, hydrophilic, swellable, enzymatically hydrolysable, three dimensional network of molecules of a polysaccharide or enzymatically hydrolysable derivatives thereof, the molecules being crosslinked by bridges with bonds of a covalent character, in which network there is also present indicatable groups or atoms (as defined) bound by means of bonds of a covalent character, a reaction taking place between the enzyme and reagent to release water-soluble fragments of the reagent and subsequent to the enzyme having reacted upon the reagent for a determined length of time, separating undissolved reagent from the liquid with the water-soluble fragments of the reagent dissolved therein, and then determining the indicatable groups or atoms in the liquid or undissolved reagent as a measure of enzyme activity. Specified enzymes are alpha-amylase and endodextranase. The indicatable groups or atoms may be colour-producing groups, fluorescent groups or radioactive isotope atoms or groups containing radioactive isotopes. The reagent can be mixed with paper pulp to form a reagent-containing paper.
Patent GB-1257689-A (GB)
IPC: G05D23/20
Filed: 1969-12-09
Abstract: 1,257,689. Automatic temperature control systems. HITACHI HEATING APPLIANCES CO. Ltd. Dec.9, 1969 [March 7, 1969], No.60131/69. Heading G3R. In an electric blanket of the type having a heating wire 4 surrounded by a signal wire 6 and separated therefrom by a dielectric material whose characteristics change with temperature, the capacity of the dielectric increases and the specific resistance decreases with temperature so that within a temperature rise to a determined value the electric charge in the dielectric retards the firing point of a thyristor 8 progressively, but beyond this point the capacitance changes sharply so that the gate/cathode voltage is insufficient to fire a neon indicator 5 and hence the thyristor 8 is not triggered into conduction. A variable resistor 10 sets the temperature range. The dielectric material is a heat sensitive polyamide composition containing a surface activator, suitable ingredients for which are given in the Specification.