Patent SG-11201811321T-A (SG)
Title: Carbamoyloxymethyl triazole cyclohexyl acids as lpa antagonists
Inventor: CHENG PETER
IPC: A61K31/4192
Filed: 2017-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111 IOU 0 1101 010 1111 010 1111 0 01 011 0111 100 1111 011 11 1110 111 011111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/223016 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: avel; SYNGENE INTERNATIONAL LIMITED, Biocon CO7D 401/14 (2006.01) A61K 31/4439 (2006.01) Special Economic Zone, Biocon Park, Plot No. 2 & 3, Born- CO7D 401/04 (2006.01) A61P 11/06 (2006.01) masandra Industrial Area IV Phase, Jigani Link Road Bom- C07D 249/06 (2006.01) A61P 35/00 (2006.01) masandra, Bangalore Karnataka 560 099 (IN). REDDI- A61K 31/4192 (2006.01) GUNTA, Ramesh Babu; #26 Iruvaram Village and Post, (21) International Application Number: Chittoor District, Andhra Pradesh, Indha Pin 517128 (IN). PCT/US2017/038216 WALKER, Steven J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (22) International Filing Date: (US). KENNEDY, Lawrence J.; c/o Bristol-Myers Squibb 20 June 2017 (20.06.2017) Company, 350 Carter Road, Hopewell, New Jersey 08540 (US). CORTE, James R.; c/o Bristol-Myers Squibb Com- (25) Filing Language: English pany, 350 Carter Road, Hopewell, New Jersey 08540 (US). (26) Publication Language: English FANG, Tianan; c/o Bristol-Myers Squibb Company, 350 (30) Priority Data: Carter Road, Hopewell, New Jersey 08540 (US). JUSUF, Sutjano; c/o Bristol-Myers Squibb Company, 350 Carter 62/352,792 21 June 2016 (21.06.2016) US Road, Hopewell, New Jersey 08540 (US). (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY (74) Agent: FARQUHARSON TORRES, Serena et al.; Bris- [US/US]; Route 206 and Province Line Road, Princeton, tol-Myers Squibb Company, Route 206 & Province Line New Jersey 08543 (US). Road, Princeton, New Jersey 08543 (US). (72) Inventors: CHENG, Peter, Tai, Wah; c/o Bristol-Myers (81) Designated States (unless otherwise indicated, for every Squibb Company, 350 Carter Road, Hopewell, New Jersey of national protection available): AE, AG, AL, AM, 08540 (US). KALTENBACH, Robert, F., III; c/o Bris- AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, tol-Myers Squibb Company, 350 Carter Road, Hopewell, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, New Jersey 08540 (US). LI, Jun; c/o Bristol-Myers Squibb DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Company, 350 Carter Road, Hopewell, New Jersey 08540 HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (US). SHI, Jun; c/o Bristol-Myers Squibb Company, 350 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, Carter Road, Hopewell, New Jersey 08540 (US). SHI, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, Yan; c/o Bristol-Myers Squibb Company, 350 Carter Road, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Hopewell, New Jersey 08540 (US). TAO, Shiwei; c/o Brs- i SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, tol-Myers Squibb Company, 350 Carter Road, Hopewell, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. New Jersey 08540 (US). ZHANG, Hao; c/o Bristol-My- —kind = — = — =_ ers Squibb Company, 350 Carter Road, Hopewell, New Jer- (84) Designated States (unless otherwise indicated, for every sey 08540 (US). DHANUSU, Suresh; SYNGENE INTER- kind of regional protection available): ARIPO (BW, GH, NATIONAL LIMITED, Biocon Special Economic Zone, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = Biocon Park, Plot No. 2 & 3, Bommasandra Industrial UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Area IV Phase, Jigani Link Road Bommasandra, Banga- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, lore Karnataka 560 099 (IN). SELVAKUMAR, Kumar- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = = = (54) Title: CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS = = (57) : The present invention provides compounds of Formula (I), or R 6 / stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or pro- = 0 Formula (1) drugs thereof, wherein all the variables are as defined herein. These com- pounds are selective LPA receptor inhibitors. ----__ 2 — ,-, X1 \ A X4 X3 / V::+ R 13 0 11 ..,,,, R 4 ei en ' .... \"•••• n0 N N I N% N ....--N \ R3 IN R 2 11 © N C [Continued on next page] WO 2017/223016 Al MIDEDIMOHNIIMMEMODIMOIIIIMIROIROMEHOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))