baber/WOPTO huggingface dataset:
Patent EP-2392574-B1 (EP)
Inventor: WESTLUND NEIL
IPC: A61K31/437
Filed: 2008-06-19
Granted: 2013-12-18
Abstract: The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention.   
where U is:
Patent EP-2381722-B1 (EP)
Inventor: THUBERT PASCAL
IPC: H04L12/56
Filed: 2005-05-31
Granted: 2017-05-24
Abstract: Mobile routers establish a tree-based network topology in an ad hoc mobile network, the tree-based network topology having a single clusterhead and attached mobile routers. Each attached mobile router has a default egress interface configured for sending messages toward the clusterhead, and ingress interfaces configured for receiving messages from attached network nodes that are away from the clusterhead. A neighbor advertisement message received from an ingress interface away from a clusterhead is used by the attached mobile router to identify specified network prefixes that are reachable via the source of the neighbor advertisement message. The attached mobile router outputs on its default upstream interface a second neighbor advertisement message that specifies the network prefix used by the attached mobile router, and the specified network prefixes from the neighbor advertisement message received on the ingress interface. Hence, connectivity is established with minimal routing overhead.
Patent EP-2392298-B1 (EP)
Inventor: COLLINS KENNETH A
IPC: A61F7/00
Filed: 2006-03-20
Granted: 2016-07-13
Abstract: A system for exchanging heat with primary coolant flowing through an intravascular catheter (12) or externally-applied pad (18) to warm or cool a patient. A secondary heat transfer element (24) can be engaged with a primary heat transfer element (22) and is not grounded when the primary heat transfer element (22) is fully engaged with the secondary heat transfer element (24) during operation. In contrast, the secondary heat transfer element (24) is grounded when the primary heat transfer element (22) is at a predetermined disengaged position relative to the secondary heat transfer element (24).
Patent EP-2402588-B1 (EP)
Inventor: BOLTZ JOACHIM
IPC: F15B3/00
Filed: 2008-01-24
Granted: 2015-07-01
Abstract: The fuel injection system (1) comprises a high-pressure fuel pump (5), which supplies a fuel to a high-pressure fuel accumulator (7). The high-pressure fuel accumulator comprises multiple injectors (8) and a central pressure boosting device (6). The pressure boosting device is provided in a fuel supply direction between the high-pressure fuel pump and the high-pressure fuel accumulator. An independent claim is also included for a pressure boosting device for a fuel injection system.
Patent EP-2902406-B1 (EP)
Inventor: MCSWIGGEN JAMES
IPC: A61P21/00
Filed: 2003-02-20
Granted: 2018-01-31
Abstract: The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
Patent EP-0013393-B1 (EP)
IPC: F16L37/22
Filed: 1979-12-19
Granted: 1983-11-23
Abstract: PCT No. PCT/CH79/00158 Sec. 371 Date Aug. 20, 1980 Sec. 102(e) Date Aug. 14, 1980 PCT Filed Dec. 11, 1979 PCT Pub. No. WO80/01311 PCT Pub. Date Jun. 26, 1980.The pipe-coupling comprises a socket member adapted to receive a nipple for connecting a compressed air hose to a fixed supply conduit, for example. The nipple can be inserted manually without any additional actuation of the socket member, since locking is effected by spring-loaded locking members which engage in a circumferential groove in the nipple. When the nipple is fully engaged, a valve arranged in the socket member is open, counter to the pressure of a spring. Release of the coupling is effected by two sliding movements, in opposite directions, of a sliding sleeve enclosing the socket member, the first sliding movement releasing the spring-loaded locking members and the second sliding movement releasing further locking members. Between the two unlocking stages, the nipple executes a short axial movement which results in closure of the valve and release of the compressed air present in the hose, so that after the further locking means have been released, the hose with nipple can be removed from the socket member without any danger. A resilient latch member prevents accidental movement of the sliding sleeve back and forth.
Patent EP-0026244-B1 (EP)
IPC: C07C51/27
Filed: 1979-09-26
Granted: 1983-10-19
Abstract: A process for preparing a mixture of polycyclic aromatic polycarboxylic acids that is substantially soluble in acetone but substantially insoluble in water which comprises subjecting a slurry containing coal to reaction with aqueous nitric acid in an atmosphere containing molecular oxygen, mechanically separating the solids in the resulting slurry, extracting the resulting solids with a polar solvent to separate therefrom a mixture of polycyclic aromatic polycarboxylic acids substantially soluble in acetone but substantially insoluble in water and a mixture of polycyclic aromatic polycarboxylic acids substantially insoluble in acetone and substantially insoluble in water.
Patent EP-0016093-B1 (EP)
IPC: E04C2/06
Filed: 1980-02-25
Granted: 1983-01-19
Abstract: PCT No. PCT/CH79/00104 Sec. 371 Date Mar. 21, 1980 Sec. 102(e) Date Mar. 20, 1980 PCT Filed Jul. 18, 1979 PCT Pub. No. WO80/00249 PCT Pub. Date Feb. 21, 1980.In the production of a body of filled plastics material, it is started from a self-supported article with open pores which can be obtained in the conventional manner. A reaction material is placed in the pores of the molded article. The pores of the molded article are sealed prior to final hardening. This can be done by means of an ultraviolet radiation source. Prior to sealing, the molded articles, without the danger of leakage of the reaction material, can be temporarily placed in a glycol/glycerol bath. The polyester resin of the coating is irradiated with UV through the glycol or glycerol bath.
Patent EP-0014981-B1 (EP)
IPC: A61K31/53
Filed: 1980-02-18
Granted: 1982-02-24
Abstract: A therapeutic composition with cytostatic action comprising an isocyanurate having the formula I   <IMAGE> in which R, R', and R'' which may be the same or different represent hydrogen or alkyl having from 1 to 4 carbon atoms, preferably hydrogen or methyl in an inert pharmaceutically acceptable diluent, carrier or vehicle. The compositions may also contain other alkylating substances such as derivatives of nitrogen mustard or fluoruracil.
Patent EP-0015531-B1 (EP)
IPC: G01N1/10
Filed: 1980-03-03
Granted: 1983-10-19
Abstract: A system for recording data is disclosed, which relate to lots to be collected, particularly to milk lots to be delivered to a central collecting station. A recorder installed on the collecting vehicle comprises the normally existing data memory and closely adjacent thereto a second memory, which has preferably the same structure and serves to store those data which are required in an analytical laboratory for an analysis of samples taken from the lots as they were collected. These data are recorded in the second memory under the control of a selector. By means of the second memory, a separate data carrier is provided, which is delivered to the analytical laboratory, in which data representing the result of the various analyses are recorded on said data carrier so as to supplement the data originally recorded thereon. In this way the data can be fully automatically collected and processed, uniform technology can be used in the system required for this purpose and, as a result, the equipment used on the collecting vehicle and in the analytical laboratory can be simplified and the overall functional reliability can be improved.
Patent EP-0019935-B1 (EP)
IPC: A63B69/06
Filed: 1980-06-03
Granted: 1983-07-20
Abstract: An exercising machine in which a belt is movable by a user against a minimum resistance has a user operated control to enable a user to increase that resistance. The belt passes round a series of rollers one or more of which can be locked against rotation by a system of pawls and ratchets or by resilient bushes. A single operating control may be used to actuate the pawls, the position of the control determining the number of rollers that are locked. For certain kinds of exercising machine, the rollers are locked against rotation in one direction only and are freely movable in the other direction. For other kinds of machine, the rollers are locked against movement in both directions.
Patent EP-0026129-B1 (EP)
Title: Device for projecting colour pictures on a screen and display system comprising such a device
IPC: H04N5/74
Filed: 1980-09-09
Granted: 1983-07-27
Abstract: 1. Device for projecting of pictures in color upon a screen (109, 309) of the type comprising a visualizing cell (101) permitting to show pictures in form of a plurality of rasters formed of parallel interlaced lines, a source of polychromatic light (102) permitting to illuminate said cell, and means (108, 308) permitting to project the picture of said cell upon a screen, the lines of the cell being grouped in a units of lines, each line of a unit permitting to visualize, corresponding to a field of grey going from black to white, the information corresponding to a determined distinct color, the device comprising additionally a color filter (106) permitting to filter the light passing by each line of the cell to obtain the corresponding determined color ; the projecting means comprising focalizing means (105) for the polychromatic radiation emitted by said source and a diaphragm (107) realizing a spatial filtration at the point of convergence of said radiation, in order to form a schlieren optique ; characterized in that said color filter (106) being exterior of said visualizing cell (101) and optically associated to it by being situated between the light source (102) and the projecting screen (109, 309).
Patent EP-0030242-B1 (EP)
IPC: A47C5/10
Filed: 1980-12-30
Granted: 1983-09-28
Abstract: A stacking chair and a metal chair frame therefor. One frame member has an U-shaped, horizontal portion and a pair of vertical front legs. The horizontal portion comprises a lateral rear portion and horizontal side portions that lie generally parallel to each other, but diverge somewhat from rear to front. Each of two flanged frame juncture members has a horizontal top and a pair of vertical side flanges; the top has a pair of horizontal edges and each side has a pair of vertical edges. One horizontal edge and two vertical edges of each are welded to the frame side portions adjacent the rear lateral portion. Rear legs with integral back-support portions are welded to the other horizontal and vertical edges, so that they are spaced apart from each other farther than are the front legs. The rear legs may be two separate members or there may be a single continuous member including both legs and joined at the top. A seat (preferably non-rigid, resilient) bridges and is secured to the frame side portions and urges them toward a truly parallel relationship, and a similar back bridges and is secured to the back-support portions and, if they diverge, urges them toward a truly parallel relationship.
Patent EP-0048421-B1 (EP)
IPC: A47K5/12
Filed: 1981-09-14
Granted: 1983-11-16
Abstract: This invention is directed to a dispenser for viscous fluids. More particularly, this invention is directed to a dispensing container comprising a container body provided at one end with a resiliently compressible portion including a mouthpiece; a storage chamber to hold material to be dispensed; piston member arranged at the other end of said container to define a boundary of the storage chamber, the piston member being movable towards and restrained from movement away from said compressible portion; a top surface to define another boundary of the storage chamber; and an elastically compressible pump having an inlet valve in the top surface, an outlet valve, and a pump chamber between the valves, said inlet valve comprising an annular slot extending circularly in the top surface symmetrically to the longitudinal axis of the container and a circular cover ring hold sealingly in front of the annular slot and elastically under constant stress, the cover ring being held by three or more spokes radiating from a hub positioned in the center of the top surface.
Patent EP-0049125-B1 (EP)
IPC: F42B8/02
Filed: 1981-09-25
Granted: 1984-08-08
Abstract: A round of ammunition comprises a casing (11) having external dimensions and shape conforming to a small arms cartridge. An axial passageway (14) in the casing (11) locates an airgun pellet (22) and a primer cap (23) which upon detonation propels the pellet (22) from a nose opening (16) of the passageway. The round is assembled by inserting the pellet (22) through a base opening (15) of the passageway (14) and then inserting the primer cap (23) into the base opening (15). The diameter of the passageway so reduces in a rearward portion (18) of the passageway as to engage and restrain the pellet at a predetermined firing position along the passageway (14).
Patent EP-0065284-B1 (EP)
IPC: E21B10/32
Filed: 1982-05-13
Granted: 1985-08-07
Abstract: A bore hole wall undercutting or reaming device in which a rotatable tubular support housing (1) (61) is adapted for rotation by drive means, has at least one circumferential guide slot in its side wall for receiving and guidingly supporting a cutting tool (4) (60) for movement outwardly to and inwardly from a cutting position. The cutting tool may comprise either a rigid and/or resilient slide or pivot lever (9) having a trailing end portion supporting a cutting member (10) thereon and a leading end portion connected to the housing by a single rigid, or pivotal pull type connection by which the housing tensions and pulls the cutting tool (4) around during a cutting operation. Adjustable cutting tool positioning means are provided which include an axially displaceable feed control rod (6) (63) with at least one camming surface thereon adapted to engage and displace the slide or pivot lever (9) relative to the housing and actuated by either one of a pair of relatively adjustable threaded members (26) (27) rotatably mounted on the housing or a tubular body (68) slidably mounted on the support housing and operable from a portion of the housing outside the bore hole.
Patent EP-0077888-B1 (EP)
IPC: G03F1/88
Filed: 1982-08-05
Granted: 1985-10-02
Abstract: A method and apparatus for generating exposure masks is disclosed which markedly reduces the number of required process steps. A plurality of recording originals are successively reproduced in reduced form on a photosensitive recording substrate. These reduced size images are adjusted and placed in registry with respect to one another by means of a computer. In order to achieve this desired result, the computer calculates from the prescribed desired coordinate values and the measured actual coordinate values of index marks included on the recording original, an angle  DELTA  phi through which the recording original must be rotated to achieve the desired orientation. The computer then acts to determine the corrected actual coordinate values of the diagonal intersection point and from these the coordinate values at which the recording substrate is to be positioned to achieve the desired in registry reproduction of the reduced size image of the recording original. This process is repeated for a number of recording originals, reduced size images of which are successively reproduced on the recording substrate, which is in each case appropriately positioned by means of the computer. The recording substrate is then developed, and the desired exposure mask is produced by photolithographic techniques.
Patent EP-0086917-B1 (EP)
IPC: C07D249/08
Filed: 1982-12-08
Granted: 1986-08-27
Abstract: Compounds of formula: 
<CHEM>
 wherein Y is -CH= or =N-, R<1> is alkyl, cycloalkyl or optionally-substituted phenyl and R<2> and R<3>, which may be the same or different, are hydrogen, alkyl, cycloalkyl, phenyl, or benzyl or together form an alkylene bridging group; and acid addition salts, metal complexes and stereoisomers thereof. The compounds have fungicidal activity.
Patent EP-0084755-B1 (EP)
IPC: A61B17/42
Filed: 1982-12-09
Granted: 1986-02-19
Abstract: 1. Pessary usable in particular for the treatment of cervico-isthmic insufficiency during pregnancy, formed by a substantially trapezoidal shaped plate, defined by two lateral sides (1, 2), a concave front side (3) and a rear side (4) also concave but longer than the front side and having, on the one hand, a circular orifice (7) for receiving the cervix of the uterus and, on the other hand, bores (13, 14, 15) for the flow of the vaginal secretions, characterized in that the two lateral sides are of convex shape.
Patent EP-0071581-B1 (EP)
IPC: G01L9/10
Filed: 1982-06-23
Granted: 1986-05-07
Abstract: An electronic transmitter for transmitting pressure values of industrial process fluids comprising an inductive sensor employing a measuring diaphragm (M) movable as a function of the pressure changes in the process fluids, so as .to produce corresponding changes in inductance and therefore corresponding signals which are suitably processed in an associated electronic circuit. The measuring diaphragm is provided with a rigid center (N) forming or carrying one or more elements (38,40) of a material exhibiting high magnetic permeability.
Patent EP-0090267-B1 (EP)
IPC: G10K11/34
Filed: 1983-03-16
Granted: 1987-02-04
Abstract: 1. An ultrasonic applicator comprising an acoustic head which has finely divided transducer elements (2), a plurality of which are electrically combined to form groups (3) by contact sheets which are placed onto the counter-surfaces (6) of the transducer elements (2), which are opposite the reflecting surfaces (5), characterised in that the contact sheets have the shape of a longitudinal strip (20; 22) which extends in the region between the ends of the transducer elements (2) at right angles to the counter-surfaces (6), that the strip (20; 22) is designed as a comb (7) with a plurality of electrical contact lugs (8) and a plurality of consecutive recesses (9; 21), where the recesses are open at the strip edge which faces away from the counter-surfaces (6) of the transducer elements (2) and where their depth of cut (h, h') in the direction of the counter-surfaces (6) of the transducer elements (2) is smaller than the overall height (H) of the strip (20; 22), that in the region of each recess (9; 21) the strip (20, 22) is provided with at least one slot (12) which extends through the strip ridge (10) from the recess (9; 21) to a gap (14) between two adjacent transducer elements (2), and thereby separates two adjacent transducer elements (2), and that the base width (c) of the recess (9, 21) is essentially greater than the width (s) of the slot (12).
Patent EP-0092209-B1 (EP)
IPC: A61C8/00
Filed: 1983-04-16
Granted: 1987-06-24
Abstract: 1. Oral implant post (1) consisting of metal, metal alloy or ceramic with a base portion (2) to be inserted into the bone which extends, by way of a glazed portion (9) of the neck zone (5), the glaze being formed from prefritted glass particles, into a mounting portion (6) for the replacement tooth, characterized in that the prefritted glass particles contain bonded particles of colouring pigment and the glaze (9) is applied only in the neck zone (5).
Patent EP-0110024-B1 (EP)
IPC: F15B11/02
Filed: 1983-09-02
Granted: 1987-06-03
Abstract: A force transmitting fluid actuator for use with a control device wherein an actuator member, movable within an actuator housing, actuates the control device due to the urging force of a plurality of pistons which can be selectively pressurized in unitary increments. The plurality of pistons are disposed within pressure chambers formed in the actuator housing in a symmetrical ring-shaped arrangement concentric to a single pressure chamber disposed on the vertical axis of the housing. A number of passageways interconnect the plurality of pressure chambers to form groupings of pressure chambers which act simultaneously in response to operation of a solenoid valve associated with each passageway. In addition to the symmetrical arrangement of the pressure chambers, the valve and passageway arrangement provide for a symmetric pressurization of the pressure chambers thereby resulting in a balanced force being exerted on the actuator. The amount of force each piston can exert on the actuator is limited by a piston stop designed to contact a portion of the housing while the actual piston force is transmitted by a spring disposed between each piston and the actuator. In this manner, fluctuations in the pressurizing force are not transmitted from the piston to the actuator.
Patent EP-0111733-B1 (EP)
IPC: G01N27/12
Filed: 1983-11-11
Granted: 1988-03-09
Abstract: 1. Fluid sensitive element, consisting of a coated, laminar and, in comparison with this coating, thick insulating material plate (1) with an upper side and an underside, in which applied to the upper side are two comblike electrodes (5, 6) each with a longitudinal electrode (5) running parallel to the side margins of the insulating material plate (1) and a plurality of prongs (6) at right angles to it, such that the prongs (6) extending alternately from the two side margins interlock, but adjacent prongs (6) are electrically separate from one another, and in which there is also applied to the insulating material plate (1), in addition to the electrodes (5, 6), a large-area resistance heating layer (3) with its connection strip conductors (2), characterized in that the resistance heating layer (3) extends in a laminar manner in the area between the electrode arrangement (5, 6) and the insulating material plate (1), and that the resistance heating layer (3) is separated from all the electrodes (5, 6) only by an insulating layer (4), which is thin in comparison with the insulating material plate (1), and into which the electrodes (5, 6) are embedded.
Patent EP-0095801-B1 (EP)
IPC: E02D7/10
Filed: 1983-05-18
Granted: 1986-08-27
Abstract: The invention relates to a hydraulic pile driver including a housing having an impact weight mounted therein for reciprocating movement, said impact weight being fastened to a piston movable in a cylinder, a supply source for liquid under pressure, a supply conduit communicating with said supply source, a liquid discharge conduit, means for alternatively connecting the said supply and discharge conduits to a cylinder chamber at one side of the piston, whereby said piston can be moved by the liquid under pressure in a direction opposite to the direction of movement of the impact weight during the work stroke, the said cylinder chamber during the work stroke of the impact weight being connected to the liquid discharge conduit. According to the invention the piston at the side remote from the said cylinder chamber is loaded by a second pressure medium, the overpressure of said second pressure medium being low with respect to the liquid pressure in the said cylinder chamber prior to the working stroke, said overpressure being independent of said liquid pressure.