baber/WOPTO huggingface dataset:
Patent BR-112023020193-A2 (BR)
Title: Proteína de ligação biespecífica, composição farmacêutica, ácido nucleico, vetor, célula hospedeira, anticorpo biespecífico, métodos para tratamento ou prevenção de câncer e para intensificar uma resposta imunológica, e, usos de uma proteína de ligação biespecífica e de um ácido nucleico
Inventor: MALHOTRA DEEPALI
IPC: A61K39/395
Filed: 2022-04-29
Abstract: proteína de ligação biespecífica, composição farmacêutica, ácido nucleico, vetor, célula hospedeira, anticorpo biespecífico, métodos para tratamento ou prevenção de câncer e para intensificar uma resposta imunológica, e, usos de uma proteína de ligação biespecífica e de um ácido nucleico.  a revelação se refere a proteínas de ligação, incluindo anticorpos, que se ligam à proteína de morte programada (pd-1 - programmed death-1) e ao imunorreceptor de células t com domínios ig e itim (tigit). a revelação fornece também composições que compreendem tais proteínas de ligação, e moléculas de ácido nucleico que codificam tais proteínas de ligação. a revelação se refere adicionalmente a métodos para o tratamento de um distúrbio ou condição com o uso de tais proteínas de ligação.
Patent CZ-38797-A3 (CZ)
Title: Process for preparing diisopinocampheylchlorobornane
Inventor: KING ANTHONY ON-PING
IPC: C07D215/18
Filed: 1995-08-07
Abstract: The present invention relates to an improved process for the in situ preparation of diisopinocampheylchloroborane which comprises reacting sodium borohydride and boron trichloride with  alpha -pinene. The diisopinocampheylchloroborane thus obtained may be used, without isolation, to reduce prochiral ketones to their corresponding alcohols in high optical purity.
Patent CZ-44595-A3 (CZ)
Inventor: HRANAC KAREL
IPC: G01B3/20
Filed: 1995-02-21
Abstract: Představuje rozšířené využití pro přesná obkročná
měření, vnitřní měření a měření
vnitřních osazení a hromadné, přesné zjišťování
odchylek. V měřidle je uložena ozubená
dělicí tyč (4) do níž při posunu pohyblivého
šoupátka (10) zaskakuje ručně ovládaná ozubená
záskočka (5) s blokační pojistkou (6),
přesně suvně uložená v pohyblivém šoupátku
(10), které je na celých délkových jednotkách
přerušovaně zajišťováno. Naměřená hodnota
je v celých jednotkách odečitatelná ze stupnice
měřítka a přesné, dílčí hodnoty z číselníkového
snímače (23). Měřidloje vybaveno příslušenstvím,
které tvoří výměnná dotyková ramena
pro vnitřní měření a měření vnitřních osazení
s vyměnitelnými dotyky
Patent SK-50098-A3 (SK)
Title: Method and device for producing ammonia
Inventor: GAM ERIC ANDREAS
IPC: C01C1/04
Filed: 1998-04-17
Abstract: Process for the preparation of ammonia at elevated pressure and temperature in an ammonia reactor, comprising passing a process stream of ammonia synthesis gas successively through at least three catalyst beds and reacting the synthesis gas in the beds;   intermediately cooling of partially reacted synthesis gas leaving the catalyst beds by heat exchange in heat exchangers arranged between each catalyst bed and withdrawing a product effluent being rich in ammonia, wherein the process stream is obtained by combining prior to introduction into a first catalyst bed, a first feed stream of synthesis gas having been preheated through indirect heat exchange during the intermediate cooling of the partially converted synthesis gas, a second feed stream of synthesis gas having been preheated by indirect heat exchange with the product effluent, and a third feed stream of synthesis gas for adjustment of temperature of the process stream and wherein the first feed stream is passed successively through the interbed heat exchangers for cooling the partially converted synthesis gas.
Patent SK-57793-A3 (SK)
Title: Benzimidazole derivatives process for their preparation and their pharmaceutical compositions
Inventor: MEDERSKI WERNER
IPC: A61P9/12
Filed: 1993-06-08
Abstract: Novel benzimidazole derivatives of the formula I <IMAGE> in which R<1>, R<2>, R<3> and Y have the meanings indicated in Patent Claim 1, and their salts exhibit angiotensin II-antagonistic properties and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure as well as of disorders of the central nervous system.
Patent CH-629930G-A3 (CH)
Title: Apparatus for setting the descent angle of an oscillating system of a balance
IPC: G04D7/12
Filed: 1980-04-02
Abstract: All the movable members (12 to 16) are actuated by cam discs (7 to 11) which detect rotational movements of ellipse (24), spiral spring (21) and degree-of-angle pulse transmitter (28) by optoelectronic sensors (25 to 27). Program sequence:   a) Clamping the discharging roller (23) and balance (22) by means of jaws (14, 15) or a claw (16); lowering of the spiral sensor (26) relative to the spiral spring and of the collet key (17) on to the collet (20). b) Turning the key (17) by means of the motor (18); engaging the key/collet; the latter now slips on its shaft (19) until the sensor (26) detects the end of the spiral spring. c) The jaws (14, 15) and claw (16) rise, and the entire oscillating system (19 to 24) now rotates, this being monitored by sensors (25 to 27). d) The number of degree pulses between the ellipse signal and spiral signal corresponds to the actual angle, electronic comparison with a previously stored desired descent angle results in the necessary angle correction. e) Second clamping of the discharging roller (23) and balance (22); making the correction by means of the motor (18) and key (17) on the collet (20) under the control of the degree-of-angle pulse transmitter (27, 28); all the members (12 to 16) rise; extraction of the oscillating system with a correct descent.   <IMAGE>
Patent CH-681129G-A3 (CH)
IPC: G04B37/11
Filed: 1991-09-09
Abstract: A plastic shell has in its bottom (14) a conical opening (15) for exchanging the battery. For sealing this opening (15), an armed closure piece (1) made of a flexible, elastic plastic is used, having at its center an axially cast truncated cone (3). The truncated cone (3) receives and secures in the axial direction a chrome steel ring (4). The chrome steel ring (4) ensures the dimensional stability of the armed closure piece (1) in the pressure contact zone (13).
Patent CZ-111991-A3 (CZ)
Inventor: UHER JAROMIR ING
IPC: E06B5/14
Filed: 1991-04-19
Abstract: Bezpečnostně dveře sú vhodné, najma pre bytové a kance-
* lárske priestory, proti násilnému vniknutiu do týchto pri-
’ estorov a zároveň poskytujú zvýšenú protipožiarnu
ochranu. Pozostávajú z dveřového křídla (1), otočné uchýleného
pomocou závesov (201, 202) na záruhni (3) a z tvarovaného
prahu. Dveřové křídlo (1) je z vonkajšej strany
tvořené tvarovaným krycím oceíovým plechom (101), ktorý
je vystužený oceíovým roštom z tenkostenných uholníkov
(102) a U profilov (103) alebo širokým ohýbaným profilom
(112). Na výstuž je vrutmi (110) upevněná tepelne a zvukovoizolačná
vrstva (108) s protipožiamou speniteínou fóliou
(107) a doska (109) s povrchovou vrstvou (111). Zárubňa
(3) je zostavená z dvoch paralelné usporiadaných rámov z
tvarovaných ohýbaných profilov (301, 302), ktoré sú vzájomne
spojené výstuhami (303, 304) a skrutkou (305) s
dištančnou vložkou (306)
Patent CS-172591-A3 (CS)
Title: Radicicol derivatives, process of their preparation and use
Inventor: SUGIMURA YUKIO
IPC: C07D493/04
Filed: 1991-06-06
Abstract: Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.
Patent CZ-213392-A3 (CZ)
Inventor: SPICKA JAROMIR ING
IPC: A23N12/10
Filed: 1992-07-09
Abstract: Vynález se týká stroje k pražení kávy a řeší uložení rotačního
bubnu tohoto stroje. Uložení bubnuje tvořeno hřídelem
(1), který prochází bubnem (5) a vnč bubnu (5) je uspořádán
ve valivých ložiskách (6). Podstata řešení je v tom, že
hřídel (1) je v místech výstupu z bubnu (5) opatřen rozpernými
vložkami (2) uspořádanými v trubce (3), která s
vůlí obklopuje hřídel (1). V rozpčrných vložkách (2) jsou
vytvořeny průduchy (4).
Patent CZ-225689-A3 (CZ)
Title: Anti-tumorous antibiotic called cedarcidine
Inventor: HOFSTEAD SANDRA JUNE
IPC: C07K14/41
Filed: 1989-04-12
Abstract: New antibiotic kedarcidin (I) is characterised by its physico-chemical properties. It comprises a non-protein chromophore and a single-chain polypeptide, of which 3 variants are present. The main variant has defined 114 aminoacid sequence; one minor variant lacks the N-terminal Ala; the other minor variant lacks the N-terminal Ala-Ser. Pref. (I) is produced by culturing the new Streptoalloteichus strain L585-6 (ATCC 53650) in a medium contg. assimilable C and N sources under submerged aerobic conditions.
Patent CZ-280491-A3 (CZ)
Inventor: TERK LUDWIG MUDR
IPC: A61C8/00
Filed: 1991-09-12
Abstract: Zubní implantát sestává z těla (1) implantátu a z pilíře (2)
implantátu. Povrchové přímky pilíře (2) implantátu svírají
souměrně k ose (3) pilíře (2) implantátu úhel (a). Pilíř (2)
implantátu je ve vzdálenosti (A) od vnější povrchové přímky
(4) těla (1) implantátu vyhnut o úhel (β) a po celé délce
vyhnutí je konstantní tlouštky (T).
Patent CS-331791-A3 (CS)
Title: Process for preparing 6-(3-dimethylaminopropionyl)forskolin
Inventor: MASHIBA AKIHIRO
IPC: A61P9/00
Filed: 1991-11-01
Abstract: Disclosed in a process for producing 6-(3-dimethylaminopropionyl)forskolin, comprising the sequential steps of:   (1) acetylating hydroxy groups in the 1-position and 7-position of a compound represented by the formula (III): <CHEM> to prepare 1-acetyl-6-(3-dimethylaminopropionyl)forskolin represented by the formula (II): <CHEM>  (wherein Ac represents acetyl group), and (2) selectively removing the acetyl group in the 1-position of the compound represented by the formula (II) in the presence of an amine represented by the formula (IV): <CHEM> (wherein R1 represents hydrogen atom or lower alkyl group having 1-6 carbon atoms, and R2 represents lower alkyl group having 1-6 carbon atoms, alkoxyalkyl group, aminoalkyl group or benzyl group) in a solvent to prepare 6-(3-dimethylaminopropionyl)forskolin represented by the formula (I): <CHEM>  (wherein Ac represents the same as defined in the formula (II)).   The compound (I) is promising as a therapeutic agent for cardiac failure.
Patent CS-488088-A3 (CS)
Title: Transdermal therapeutic system
Inventor: BECHER FRANK
IPC: A61K9/70
Filed: 1988-07-05
Abstract: PCT No. PCT/DE88/00370 Sec. 371 Date Apr. 3, 1989 Sec. 102(e) Date Apr. 3, 1989 PCT Filed Jun. 21, 1988 PCT Pub. No. WO89/00437 PCT Pub. Date Jan. 26, 1989.The invention relates to a transdermal therapeutic system for administering or applying active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control means controlling the delivery of the active substance through the system and a contact adhesive means for fixing the therapeutic system to the skin, in which the active substance depot is a multichamber system, in which discreet chambers contain one or more active substances.
Patent CZ-103195-A3 (CZ)
Title: Process and apparatus for separating gaseous mixture by cryogenic distillation
Inventor: RIETH NORBERT
IPC: B01D53/02
Filed: 1995-04-21
Abstract: In order to increase the prodn. of an air distn. plant (15), contg. structured packing, to a value above the nominal prodn. rate, an air blower (1) is installed before the inlet air compressor and the plant is operated at a higher pressure. Heat exchange units are varied to suit the increased mass flow rate and the cycle time for adsorptive purifiers is decreased. <IMAGE>
Patent CZ-105197-A3 (CZ)
Title: Arrangement of auxiliary heating body
Inventor: BAUER DIETER
IPC: F28D1/04
Filed: 1995-09-29
Abstract: The invention relates to the arrangement of an additional heater for the coolant circuit in an internal combustion engine of a motor vehicle consisting of a coolant circuit including the coolant/air radiator and a heating circuit including the coolant/air heat exchanger for heating the passenger compartment. The technical problem in coolant circuits in modern, especially diesel, engines lies in the fact there is too little heat available for the heating system; thus additional heaters, e.g. using fuel, are in use. It is proposed that the additional heater using fuel and consisting of a burner and a heat exchanger be fitted directly on the coolant/air radiator of the vehicle or be integrated into the radiator. This arrangement has the advantage that the burner with its fuel and exhaust pipes is outside the passenger compartment and thus does not adversely affect comfort and safety therein. In addition, the inclusion of the additional heater in the flow of the coolant circuit is simpler and more economical.
Patent CZ-105695-A3 (CZ)
Title: Needle felt with a pattern as a floor covering
Inventor: HAIBER GERD
IPC: D04H1/52
Filed: 1995-04-25
Abstract: A patterned needle felt floor covering comprises a needle felt into which a flat, at least partially coloured and/or patterned yarn system has been needle punched. Also claimed is the process of placing a coloured and/or patterned flat yarn system on a non-woven fibre batt or between two fibre batts and needle punching them together simultaneously or sequentially.
Patent CZ-135293-A3 (CZ)
Title: Device for arranging full non-circular sliver cans
Inventor: JEZEK JAN ING
IPC: D01H9/00
Filed: 1993-07-02
Abstract: This device for planning cans (4) on a output walking conveyer (2) contains a basic frame (21) with a front bearing area (211) and a rear bearing area (212) between which there is an adjusting mechanism (22) containing a height and length adjustable platform (222) on the front side (225) of which there is at least one stop unit (226) extending above the upper area of the platform (222). The rear bearing area (212) of the basic frame (21) is coupled to the stop unit (5) on the beginning of which there is a leading area (51).<IMAGE>
Patent CZ-136794-A3 (CZ)
Title: Process for producing cast jewels
Inventor: MULLER MANFRED
IPC: B22D25/02
Filed: 1992-12-03
Abstract: In order to produce pieces of jewellery with one or several set stones, a master pattern with settings for the stones is produced, a master mould is produced by moulding from the master pattern, a model is produced in the master mould with a castable or injection mouldable modelling mass that can be ejected by heating from the master mould, the stones are inserted into the model and set by deformation of the setting, a casting mould is produced by embedding the model in a fire-resistant moulding mass and by ejecting the modelling mass from the casting mould, metal is cast into the casting mould by a spin casting or vacuum moulding process and the piece of jewellery is removed from the mould once the metal has cooled down.
Patent CZ-141599-A3 (CZ)
Title: Process for preparing esters of [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
Inventor: LERMAN ORI
IPC: C07D241/04
Filed: 1999-04-21
Abstract: The invention provides a process for the preparation of esters Ä2-Ä4-Ä(4-chlorophenyl)phenylmethylÜ-1-piperazinylÜethoxyÜacetic acid, of the formula (I) <CHEM> wherein X represents a halogen atom and R represents a lower alkyl group comprising reacting:     (a) a compound of the formula (II) <CHEM>     (b) a compound of the formula (III) <CHEM>  and   (c) a tertiary amine as a solvent and as an acid scavenger at a temperature of at least 100 DEG C, wherein X is a halogen atom, X' is selected from the group consisting of bromine and chlorine and R is a lower alkyl group.
Patent CZ-200731-A3 (CZ)
Inventor: KLOFAT PETR
IPC: A47J44/00
Filed: 2007-01-11
Abstract: Kuchynský strojek s váhou obsahuje alespon zpracovací ústrojí s nádobou na zpracovávaný materiál a vážící zarízení, pricemž nádoba na zpracovávaný materiál je provedena jako vážící mísa (11), která je stále nebo volitelne oprena o alespon jeden vážící snímac (12), uložený v kuchynském strojku (10).
Patent CZ-276694-A3 (CZ)
Title: Process for preparing diphenyl derivative
Inventor: BAKER STEPHEN RICHARD
IPC: C07C69/736
Filed: 1992-11-23
Abstract: Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists.
Patent CZ-318895-A3 (CZ)
Title: Absorption article with a barrier cuff folded in "z" shape
Inventor: FEIST BARRY ROBERT
IPC: A61F5/44
Filed: 1994-05-23
Abstract: A Z-folded barrier cuff is provided to allow both sufficient lateral spacing of the barrier cuffs for the genitals in the front and for BM containment in the back as well as sufficient cuff height in the crotch area for good fit into the leg crease and good containment of body exudates. The barrier cuff is Z-folded by folding a first portion back upon itself such that a first segment and a second segment is formed. A second portion is folded laterally inwardly back upon itself such that a third segment is formed. Thus, the Z-folded barrier cuffs are properly laterally spaced in the crotch area and near the end edges while providing sufficient height to properly contain body exudates.
Patent CZ-321299-A3 (CZ)
Title: Paper glued with gluing agent based on 2-oxetaton prepared from normal and branched fatty acids
Inventor: MALMSTROEM OLOF
IPC: D21H17/17
Filed: 1998-03-11
Abstract: The present invention relates to a method of manufacturing a paper grade containing precipitated calcium carbonate as filler. According to the invention, the ink-jet printability of said paper grade is advantageously improved by using a 2-oxetanone size, which is made starting from non-branched and branched-chain fatty acids having main chain comprising 6-22 carbons linked with each other by saturated bonds.
Patent CZ-9903279-A3 (CZ)
Title: Fractionalization process of amaranth flour and apparatus for making the same
Inventor: JELINEK MILOS ING CSC
IPC: A23L19/10
Filed: 1999-09-16
Abstract: Disclosed is fractionalization process of amaranth flour that is characterized in that the amaranth flour is mixed with water and let to settle. Subsequently separation of solid and liquid phases is carried out. The liquid phase is then cooled down, stirred and neutralized below isoelectric point. Precipitate of proteins is then thickened and dried under temperature mode that does not cause denaturation and damage of proteins. Prior mixing with water the amaranth flour is subjected to fat separation. After separation of proteins, the solid phase is subjected to mechanical treatment, during which starch is squeezed out of fibrous matter and after stoppage of the mechanical action, the fibrous matter is let to settle, starch is separated and precipitated by acidification thereof. The remaining settled fibrous matter is washed, subjected to a repeated settling and centrifugally separated through a filter cloth (10). Apparatus for carrying out the process comprises a reaction vessel (1) for separation of protein. Said  reaction vessel (1) is interconnected with another reaction vessel (2) intended for precipitation of protein. Said protein precipitation vessel (2) is followed up with a centrifuge (22) and a rotary vacuum evaporator (11). Said reaction vessel (1) for separation of protein is interconnected with another reaction vessel (3) for separation of starch. This starch separation vessel (3) being provided with a pressure element (7) is connected to a reaction vessel (4) for starch precipitation, which is in turn followed up with the rotary vacuum evaporator (11). Separated fibrous matter is conducted from said starch separation vessel (3) in a centrifuge (9) being provided with a filter cloth  (10) and further in a hot-air drier (12).
Patent CZ-9903578-A3 (CZ)
Title: Blower of heating unit combustion air, particularly for motor vehicles
Inventor: LINKA PETR ING
IPC: B60H3/00
Filed: 1999-10-08
Abstract: The present invention relates to a heating unit combustion air blower, particularly for motor vehicles, wherein the unit generates heat by combustion of Diesel oil products, the heating unit comprising a rotor (41) having the form of a disk with radial blades (412) arranged within a ring-shaped cavity (411) being performed in the rotor (41) front end peripheral region. The shape of the ring-shaped cavity (411) is approximately half-round and the rotor (41) is turned by its inner face toward inner face of a blower housing (42) with a side channel (423) performed in mirror-like manner and having the shape of the ring-shaped cavity being interrupted by a radial partition wall (424). On one side of said radial partition wall (424), there is performed at the beginning of the side channel (423) a combustion air radial inlet channel (425) and on the other side thereof there is performed at the end of the side channel (423) a substantially tangential outlet channel (426) entering on the other side an internal cavity (427) performed in the blower housing (42) external face. In central portion of the blower (4) housing (42) internal face, there is performed coaxial to said ring-shaped side channel (423) an outlet hole (428) interconnecting the cavity (427) on the housing (42) external face with a space turned toward the housing (42) internal face (42) and opposite to said hole, there are arranged axial blades (414) performed in the rotor (41) central region in annular space extending between the rotor (41) hub (413) and inner peripheral wall (429) of the rotor (41) ring-shaped cavity (411).
Patent ES-8800879-A3 (ES)
Title: Apparatus for supplying sheets individually
IPC: B65H3/06
Filed: 1985-12-30
Abstract: Apparatus for separating, counting and stacking sheets, which includes a feed roller and an interacting pull-out shoe for allowing the passage of only one sheet between them, said sheets advancing along a curved path defined by a guide plate which interacts with the feed roller when the sheet emerges from the region between the pull out shoe and the feed roller. The front edge of the sheet which advances along said curved path enters a contact line between an acceleration roller and an idle acceleration roller mounted on a common shaft with the feed roller in order suddenly to accelerate the sheet and to carry it to a stacking wheel which distributes the sheet to an output stacker. The feed roller has a plurality of surfaces with different coefficients of sliding friction in order to facilitate separation of the sheets.
Patent ES-8802056-A3 (ES)
Title: Ribofuranosyl triazole carboxylic acid ester prepn.
IPC: A61K31/70
Filed: 1986-10-31
Abstract: The methyl ester of 1-(beta-D-ribofuranosyl) 1,2,4-triazole 3-carboxylic acid, for use as an anti-tumour agent, is made by (a) reacting suitable molar amounts of the methyl ester of 1-(2,3,5-tri-O-benzoyl beta-D-ribofuranosyl) 1,2,4-triazole 3-carboxylic acid with sodium methoxide in methanol (b) refluxing the soln. for 45 mins. (c) neutralising with 'Biarad AG50-X2(K) (d) filtering (e) evaporating the soln. in a rotary evaporator at 35 deg.C under reduced pressure to form a syrup and (f) crystallising from methanol/ethyl acetate.