Patent SG-11201811408P-A (SG)
Title: Adoptive cell transfer and oncolytic virus combination therapy
Inventor: WAN YONGHONG
IPC: A61P35/00
Filed: 2017-06-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1#11101111 0 11101 HOE 010 1111 1 0 013 OH 11111 3100110111110 1111 011 International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/219150 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 39/00 (2006.01) A61P 37/02 (2006.01) A61K 35/66 (2015.01) CO7K 16/28 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 35/768 (2015.01) Cl 2N 5/0783 (2010.01) A61P 35/00 (2006.01) Cl 2N 7/01 (2006.01) A61P 35/04 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/CA2017/050772 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 23 June 2017 (23.06.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/354,506 24 June 2016 (24.06.2016) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant: MCMASTER UNIVERSITY [CA/CA]; 1280 KM, ML, MR, NE, SN, TD, TG). Main Street West, Hamilton, Ontario L8S 4K1 (CA). (72) Inventors: WAN, Yonghong; c/o McMaster University, Published: 1280 Main Street West, Hamilton, Ontario L8S 4K1 (CA). — with international search report (Art. 21(3)) — WALSH, Scott; c/o McMaster University, 1280 Main — with sequence listing part of description (Rule 5.2(a)) = Street West, Hamilton, Ontario L8S 4K1 (CA). CHEN, Lan; c/o McMaster University, 1280 Main Street West, =_ Hamilton, Ontario L8S 4K1 (CA). SALEM, Omar; c/o Mc- = Master University, 1280 Main Street West, Hamilton, On- = tario L8S 4K1 (CA). SIMOVIC, Boris; c/o McMaster Uni- = _ versity, 1280 Main Street West, Hamilton, Ontario L8S 4K1 = — (CA). Agent: NAUMAN, David et al.; Borden Ladner Gervais (74) LLP, World Exchange Plaza, 100 Queen Street, Suite 1300, Ottawa, Ontario KIP 1J9 (CA). = = = Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, = = Title: ADOPTIVE CELL TRANSFER AND ONCOLYTIC VIRUS COMBINATION THERAPY (54) = = FIGURE 5 = 40 n fidpi = 12dp1 8 90 + 1-1 20 1 l .4 U. 10 0 ki) R Il 0 01 / Il ei IN AcP ,0 ,f , ...tb 4 4 I , kc' N.b` 1-1 f's / 0 ei (57) : The present invention describes a method for treating cancer comprising adoptive transfer of tumor antigen specific ..) CD8+ T cells and an oncolytic virus vaccine targeting the same antigen.