Patent SG-11201803975S-A (SG)
Title: Improved tnf binders
Inventor: BUYSE MARIE-ANGE
IPC: C07K16/24
Filed: 2016-11-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date .... .crs..1 18 May 2017 (18.05.2017) WIPO I PCT (10) WO International Publication Number 111111111111311111111111111111111111111111111111111111111111111111111311111111111111111 2017/081320 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/18 (2006.01) C07K 16/24 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/EP2016/077595 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 14 November 2016 (14.11.2016) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 62/254,375 12 November 2015 (12.11.2015) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: ABLYNX NV [BE/BE]; Technologiepark 21, kind of regional protection available): ARIPO (BW, GH, 9052 Ghent-Zwijnaarde (BE). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: BUYSE, Marie-Ange; Burgemeester Edmond TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Ronsestraat 23, 9820 Merelbeke (13E). BOUCNEAU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Joachim; Elsbos 41, 9840 De Pinte (BE). CASTEELS, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Peter; Lindekouter 20, 9420 Erpe-Mere (BE). VAN LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, HEEKE, Gino; Omloop 35 #203, 9700 Eine (BE). SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (74) Agents: STEFFERL, Andreas et al.; HOFFMANN Published: EITLE Patent- and Rechtsanwalte PartmbB, ArabellastraBe 30, 81925 Munich (DE). — with international search report (Art 21(3)) [Continued on next page] Title: IMPROVED TNF BINDERS (54) Figure 2 10 20 30 40 SEQ ID NO: 58 QVQLVESGGGLVQAGGSLRLSCTASGQTSSTADMGWFRQP - 5 , - q , SEQ ID NO: 1 E P A SEQ ID NO: 59 E V P F F . A 50 60 70 80 SEQ ID NO: 58 PGKGREFVARISGIDGTTYYDEPVKGRFTTSRDKAQNTVYL SEQ ID NO: 1 S N.K..1... SEQ ID NO: 59 S N.K..L.. I'l .4t 90 100 110 -- abc -- : ---- 1 ---- ---- : labcd ---- ---- : 1 ---- o ei SEQ ID NO: 58 QMDSLKPEDTAVYYCRSPRYADQMSAYDYWGQGTQVTVSS - en SEQ ID NO: 1 N.. L L Il SEQ ID NO: 59 N. k L L Ge C —..„ It-- 1-1 (57) : The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor N alpha (\"TNF\" or \"TNF-alpha\"). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as \"ISV's\" or \"ISVDs\") binding to tumor necrosis factor alpha, as well as to proteins, polypeptides C and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein. WO 2017/081320 Al MIDEDIMO1101010111010101011EIMM10010101101110VOIMIE — before the expiration of the time limit for amending the — with sequence listing part of description (Rule 5.2(a)) claims and amendments to be (Rule republished 48.2(h)) in the event of receipt of