baber/WOPTO huggingface dataset:
Patent NZ-219338-A (NZ)
Title: Monoclonal antibody to non-small cell lung carcinoma, its use, production and antigen
Inventor: HELLSTROM KARL ERIK
IPC: C07K16/00
Filed: 1987-02-19
Abstract: The present invention is concerned with novel monoclonal antibodies which bind strongly to a protein antigen associated with human non-small cell lung carcinomas ("NSCLC") human small cell lung carcinomas and certain other human carcinomas including many carcinomas of the colon and breast. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use both in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods for treatment of human in NSCLC and certain other human carcinomas. Also disclosed is a novel 110,000 dalton glycoprotein antigen found on the cell surface of human non-small lung carcinoma tumor cells and on cells from certain other human cancers. The amino terminal amino acid sequence of this antigen is:  <IMAGE> +TR  <IMAGE>  in which X represents an unidentified amino acid.
Patent NZ-237168-A (NZ)
Title: Substituted imidazole derivatives and pharmaceutical compositions
Inventor: COZZI PAOLO
IPC: A61P15/00
Filed: 1991-02-20
Abstract: PCT No. PCT/EP91/00351 Sec. 371 Date Oct. 25, 1991 Sec. 102(e) Date Oct. 25, 1991 PCT Filed Feb. 26, 1991 PCT Pub. No. WO91/13062 PCT Pub. Date Sep. 5, 1991.1-(Alkoxy-iminoalkyl)imidazole derivatives of formula  (* CHEMICAL STRUCTURE *) (I) wherein R is hydrogen or C1-C4 alkyl; A is C1-C4 alkylene optionally substituted by phenyl optionally substituted by halogen or trifluoromethyl; R is (a) hydrogen or a C1-C10 hydrocarbon radical; (b) an aryl or aryl-C1-C4 alkyl group wherein the said aryl is optionally substituted either by halogen, trihalo-methyl, C1-C4 alkyl, C2-C3 alkenyl, C2-C6 alkynyl, C1-C4 alkoxy, C1-C4 alkylthio or C1-C4 alkylsulfonyl or by C5-C8 alkyl, C4-C8 alkenyl, C5-C8 alkoxy, C5-C8 alkylthio or phenyl optionally substituted by halogen, trihalomethyl or C1-C4 alkyl; or (c) a C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C4 alkyl group, wherein the said cycloalkyl is optionally substituted by C1-C4 alkyl; T is a C1-C6 hydrocarbon chain or phenylene; X is a bond, -O-CH2-, -C(R' R")-, Si(R' R")-, vinylene or isopropenylene, each R' and R" being hydrogen, fluorine or C1-C4 alkyl; and R2 is -OR3 or -N(R3R4), each R3 and R4 being hydrogen, C1-C6 alkyl, phenyl or benzyl; and the pharmaceutically acceptable salts thereof; are useful in the treatment of a disease state related to enhancement of thromboxane A2 (TxA2) synthesis.
Patent NZ-240282-A (NZ)
Title: Phenyl pyrazole derivatives; herbicidal compositions and use, and preparatory processes
Inventor: DUTRA GERARD ANTHONY
IPC: C07D409/04
Filed: 1991-10-18
Abstract: The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.
Patent NZ-240397-A (NZ)
Title: Botanic seed analogs comprising plant tissue encapsulated in oxygenated hydrated gel and their use in germinating plant tissue
Inventor: CARLSON WILLIAM C
IPC: A01H4/00
Filed: 1991-10-29
Abstract: A manufactured seed is disclosed which comprises a plant embryo preferably encapsulated, or at least in contact with, a hydrated oxygenated gel. The gel can be oxygenated by passing oxygen gas through a gel solution before curing the gel or by exposing the gel to oxygen gas after curing. The gel is preferably oxygenated by adding to an uncured gel solution a suitably stabilized emulsion of a perfluorocarbon compound or a silicone oil, which compounds are capable of absorbing large amounts of oxygen, and are non-toxic and inert. The seed analog can further comprise an outer shell at least partially surrounding the gel and embryo, thereby forming a capsule. The outer shell preferably is shaped to aid the radical of a germinating embryo in protrusively rupturing the capsule, thereby facilitating successful germination and minimizing incidence of seedling malformation. Other shell materials are selected to provide requisite rigidity to the capsule while imparting minimal restriction to successful germination. In a preferred embodiment for germinating embryos having cotyledon(s), at least the cotyledons are enclosed in a porous material resistant to penetration by the growing cotyledon(s), and the embryo and porous enclosure are encapsulated in a hydrated gel.
Patent NZ-245969-A (NZ)
Title: Digitally controlled waveform generator for iontophoresis: inductor discharge
Inventor: TEILLAUD ERIC
IPC: H02M3/157
Filed: 1993-02-23
Abstract: The device comprises a switched mode power supply (1) equipped with an electronic switching element (T1), the closing of which supplies an inductor (L1) which discharges, on reopening the element, into a capacitor (C1) across whose terminals the output voltage of the device appears, characterised in that it comprises (a) memory means for recording a series of numbers reflecting successive segments of the predetermined waveform, (b) a clocked digital counter (2), and (c) means (3) for successively loading this counter (2) with each of the numbers of the series as a bound for the counting effected by the counter (2), the latter cyclically closing the switching unit (T1) for a predetermined time interval whenever the counting effected attains the bound thus fixed. <IMAGE>
Patent NZ-247044-A (NZ)
Title: Use of ranolazine and related piperazine derivatives to treat tissue affected by muscle and neuronal damage, including transplant tissue
Inventor: DOW ROBERT JAMES
IPC: A01N1/02
Filed: 1990-06-21
Abstract: Piperazine derivatives, particularly ranolazine, are useful for treatment of tissues experiencing a physical or chemical insult, and specifically for treating shock conditions.
Patent NZ-259596-A (NZ)
Title: Sugar-substituted glucocorticosteroid and use in medicaments specific to the colon or ileum
Inventor: BRATTSAND RALPH LENNART
IPC: C07J71/00
Filed: 1993-12-17
Abstract: Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula GCS1-O-Sugar1 for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their preparation, pharmaceutical preparations containing the compounds and the use of said compounds in therapy.
Patent NZ-266014-A (NZ)
Title: Genes encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
Inventor: DENOYA CLAUDIO D
IPC: C12N/
Filed: 1994-05-30
Abstract: The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin and of producing novel avermectin through fermentation.
Patent NZ-278676-A (NZ)
Title: A medicinal plant-derived antiviral powder
Inventor: KADONO TOSHIKO
IPC: A61K36/00
Filed: 1995-01-20
Abstract: An antiviral powder originating in a medicinal plant having an antiviral activity is prepared by rapidly heating the plant immediately after being harvested to deprive the same of the enzymatic activity, drying the deactivated plant at low temperature, and pulverizing the same after the rapid heating or low-temperature drying. An antiviral extract is prepared by extracting the powder with hot water or a lower alcohol. A pharmaceutical preparation containing the powder and the extract each in an effective dose is utilized especially as a powder. Examples of the medicinal plant include young leaves of lacquer tree and flowers of Japanese elm.
Patent NZ-301463-A (NZ)
Title: Skin irritation inhibition compositions containing aqueous-soluble divalent strontium cation
Inventor: HAHN GARY SCOTT
IPC: A61K33/00
Filed: 1995-12-21
Abstract: A composition for topical application to an animal subject comprising: a topical vehicle; an irritant ingredient  capable of inducing skin irritation in a subject; and at least 50mM of an aqueous divalent strontium cation (Sr2+).
Patent NZ-311087-A (NZ)
Title: Valve bearing replacement
Inventor: STOCKTON ROY
IPC: F16K43/00
Filed: 1996-06-20
Abstract: PCT No. PCT/GB96/01456 Sec. 371 Date Aug. 7, 1998 Sec. 102(e) Date Aug. 7, 1998 PCT Filed Jun. 20, 1996 PCT Pub. No. WO97/01056 PCT Pub. Date Jan. 9, 1997A method of removing or replacing a trunnion bearing of a rotary valve having a downstream side with a downstream connection and having an upstream side with an upstream connection to a high pressure penstock, the rotary valve including a valve rotor inside a valve body, the valve rotor having a trunnion within a trunnion bearing. The method includes the steps of closing the valve; separating the valve from its downstream connection; offering up a support tool to the valve body to support the valve rotor on its downstream side; connecting a pressure-retaining closure tool to the valve body on the downstream side of the valve body and in so doing forming a space between the closure tool and the support tool; pressurizing the space between the support tool and the pressure-retaining closure tool to balance a load due to a pressure at the upstream side acting on the valve rotor; adjusting the position of the support tool in order to support the valve rotor against the upstream load and to bring the rotor and its trunnion in a location enabling its bearing to be removed; securing the valve rotor in its bearing removal location by a mechanical locking structure; reducing the pressure in the space between the support tool and the pressure-retaining closure tool; and removing the trunnion bearing.
Patent NZ-313667-A (NZ)
Title: a DNA sequence for encoding mutated 5-enol pyruvylshikimate-3-phosphate synthase, the protein and transformed plants containing said DNAne
Inventor: LEBRUN MICHEL
IPC: C12N15/54
Filed: 1996-07-18
Abstract: DNA sequence coding for a mutated 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), characterised in that the EPSPS is from maize and comprises a first mutation consisting in a substitution of  threonine 102 to isoleucine and a second mutation consisting in a substitution of proline 106 by serine. Also included is the method for the production of producing glyphosate-resistant transformed plants with improved tolerance to herbicides having EPSP synthase as its target.
Patent NZ-324314-A (NZ)
Title: Process for the diagnosis and treatment of squamous cell carcinomas based on the expression of the variable exon v6 of the CD44 gene
Inventor: HEIDER KARL-HEINZ
IPC: A61K31/00
Filed: 1996-12-05
Abstract: The invention concerns a method of diagnosing and treating squamous cell carcinomas, the method being based on the expression of the variant exon v6 of the CD44 gene as the molecular target. In a preferred embodiment, v6-specific antibody molecules, in particular the monoclonal antibody BIWA-1 (VFF-18), are used for this purpose.  The preferred processes are those characterised in that an antibody molecule is used which recognises the amino acid sequence QWFGNRWHEGYRQT, more preferably the amino acid sequence WFGNRWHEGYR.
Patent NZ-333108-A (NZ)
Title: The use of L-lysine in the manufacture of a medicament for the treatment of hair loss
Inventor: RUSHTON DAVID HUGH
IPC: A61K8/00
Filed: 1997-06-06
Abstract: The use of L-lysine in the manufacture of a medicament for the prophylaxis and treatment of hair loss in humans is claimed provided that the L-lysine is not in the form of a complex with a transition metal and the medicament does not contain one or more of the following: a) a combination of trigonelline and vitamin B6; b) pantothenic acid either alone or in combination with a divalent iron and methionine; c) garlic oil or garlic extract or d) oestrogenic hormone or derivatives thereof. A pharmaceutical composition for the prophylaxis and treatment of telogen effluvium in humans is claimed containing 200 to 200 mg  of L-lysine and one or more of the following: e) an iron compound such that the amount of elemental iron is 14-300 mg and is selected from iron (II) sulphate, iron (II) fumarate, iron (II) gluconate, iron (II) succinate, iron (II) glycine sulphate or another chelated iron compound; f) from 14-300 mg vitamin C and g) from 3mg to 24mg of vitamin B12.
Patent NZ-333575-A (NZ)
Title: Electricity line support, made from inorganic fibres bound by inorganic cements
Inventor: STANLEY EARL K
IPC: E04H12/02
Filed: 1997-06-26
Abstract: Supports (4) for power transmission lines are made of inductively transparent, inorganic cement composite materials. Separate parts of the structure are provided with mating surfaces and are secured together by expanding grout. When the structure is in the form of a pole (4), the bottom of the pole can be attached to a base (28) by sleeves (24) secured to the pole (4).
Patent NZ-334776-A (NZ)
Title: Hot dieless foiling by applying and curing adhesive on substrate, heating to make adhesive tacky, and transferring pigmented or metallic layer from foil to substrate
Inventor: BRADBURY-HARRIS GRAEME WILLIAM
IPC: B41F19/06
Filed: 1999-03-19
Abstract: Apparatus and methods are disclosed for a "hot" dieless forming technique that is stated to overcome  problems in adapting dieless forming to existing printing apparatus having a turner roller (that would otherwise prevent dieless forming).
Patent NZ-335438-A (NZ)
Title: Apparatus for attaching a casing to a drill bit in overburden drilling equipment
Inventor: SPEDALE ANGELO LEE
IPC: E21B17/046
Filed: 1997-11-05
Abstract: Provided is an overburden drilling device which includes a drill bit body, a percussion element for applying impacts to the body, and a casing attached to the body. The casing is connected to the drill bit body by a casing shoe which comprises semi-cylindrical halves which are held together by a circular ring that is welded to the halves. The casing shoe and the drill bit body are interconnected by radially overlapping walls so that the drill bit body pulls the casing along during a drilling operation.
Patent NZ-337178-A (NZ)
Title: Substituted succinic acid surfactants and their use as thickeners in personal care compositions
Inventor: CARPENTER NEIL MICHAEL
IPC: C09K23/42
Filed: 1998-02-24
Abstract: Compounds of the formula R2.[(AO)n.R3]m, where R2 is a residue of a group having at least m active hydrogen atoms derived from hydroxyl and/or amino and/or amido groups, AO is alkyleneoxy, n is 2 to 200; R3 includes residue(s) of alkenyl succinic acids and optionally other acids, and m is 2 to 10, but when m is 2 there are other restrictions in the definitions, are disclosed as useful thickeners and/or dispersants in aqueous systems. The use of such materials as thickeners is also disclosed.
Patent NZ-506137-A (NZ)
Title: Screw drum type filtration device
Inventor: KATABE TOYOKAZU
IPC: B01D33/11
Filed: 1999-11-18
Abstract: An arrangement comprising a filter cylinder (1) composed of an approximately horizontally extending alternately superposed array of fixed plates (8) having circular or approximately circular openings, and annular floating plates (9) having geometrically similar openings (13) slightly larger in diameter than the openings in the fixed plates and also having circular outer peripheries, with small filtration clearances defined, the row of openings in the fixed plates defining a cylindrical space having a fixed inner peripheral contour (3), it being arranged that when the row of openings in the floating plates is positioned outside the cylindrical space, at least two equi-level regions in the lower portion of the outer periphery of the floating plate are exposed beyond the outer edge of the fixed plate, a screw (2) extending through the cylindrical space, and eccentric shafts (12) contact-wise supporting the exposed outer peripheral portions of the floating plates and eccentrically rotated, so as to swing the floating plates.
Patent NZ-508154-A (NZ)
Title: N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
Inventor: ALLEN DOUGLAS JOHN MELDRUM
IPC: A61P35/00
Filed: 1999-04-08
Abstract: A compound selected from the anhydrous and hydrate forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate. Also described is the use of the above compound in the manufacture of medicaments for treating hyperproliferative diseases.
Patent NZ-510996-A (NZ)
Title: A winder with improved winding and cutting assembly for a strapping machine for placing a strap around a load
Inventor: HABERSTROH JAMES A
IPC: B65B13/18
Filed: 2001-04-06
Abstract: A winder (28) for a strapping machine that positions a strap material around a load and tensions the strap material around the load comprises a rotating head having a stationery element and a pivotal element.  The stationery (30) and pivotal elements (32) each define an outer surface around which the strap material is wound and defines a slot therebetween for receiving the strap material.  The stationery and pivotal elements each define a gripping portion (44, 46) at the respective ends opposingly facing one another.  The pivotal element is pivotal between an open position in which the gripping portions are spaced from one another and a close position in which the gripping portions co-operate with one another to engage and secure the strap material therebetween. The winder rotates from a home position in which a winder is in the open position and an other position than the home position in which the winder is in the closed position.
Patent NZ-512000-A (NZ)
Title: New amidino derivatives and their use as thrombin inhibitors
Inventor: INGHARDT TORD
IPC: C07D207/16
Filed: 1999-12-10
Abstract: Compounds of formula I are described, wherein the variables are defined herein. The compounds are used in the manufacture of medicaments for the treatment of conditions for which inhibition of thrombin is required.
Patent NZ-513188-A (NZ)
Title: Insulator
Inventor: TAN VICTOR WONG
IPC: H01B17/14
Filed: 1999-11-12
Abstract: An insulator including a mounting portion for mounting the insulator to a surface, and a securing portion for securing a length of material relative to the insulator, and a securing portion capable of being moved to release the length of material with respect to the insulator, the insulator characterised in that the movement of the securing portion to allow release of the length of material is contained within the insulator
Patent NZ-515110-A (NZ)
Title: Promoter
Inventor: DONALDSON IAIN ALASDAIR
IPC: C12N9/10
Filed: 2000-06-15
Abstract: A promoter is described. The promoter comprises a nucleotide sequence corresponding to that shown as SEQ ID No. 1 or a functional variant, homologue or derivative thereof, and an Escherichia coli strain containing said nucleotide sequence deposited as NCIMB 41011
Patent NZ-515178-A (NZ)
Title: Modulating prolactin receptors to affect a physiological response
Inventor: NIXON ALLAN
IPC: A61K38/22
Filed: 2001-11-23
Abstract: A method for affecting a physiological response of a non-human animal to circulating levels of prolactin and/or prolactin mimetics. The method is characterized by modulating prolactin receptors by effectively signaling a sustained increase in the circulating level of prolactin and/or prolactin mimetics, followed by a decrease back to normal or low levels. The levels of circulating prolactin may also be increased by incorporating into a non-human animal's genome an inducible recombinant nucleotide sequence encoding biologically active prolactin.
Patent NZ-517666-A (NZ)
Title: Transgenically produced fusion proteins
Inventor: EDGE MICHAEL D
IPC: A01K67/027
Filed: 2000-09-18
Abstract: A method of making a transgenic fusion protein comprising providing a transgenic non-human animal which includes a transgene which provides for the expression of a functional or biologically active fusion protein; allowing the transgene to be expressed; and recovering the fusion protein from the milk of the transgenic animal.
Patent NZ-518901-A (NZ)
Title: A levetiracetam alone or in combination with a compound inducing neural inhibition mediated by the GABA receptors for treatment of chronic pain, bipolar disorder, mania and migraine
Inventor: LAMBERTY YVES
IPC: A61K31/197
Filed: 2000-11-27
Abstract: Levetiracetam is used in the manufacture of a medicament for the treatment of bipolar disorders, mania, migraine and chronic or neuropathic pain. Also described is a pharmaceutical composition comprising levetiracetam and at least one compound inducing neural inhibition mediated by the GABAA receptor. Preferably the compound is selected from benzodiazepines, 1,4 benzodiazepines, 1,5 benzodiazepines, barbiturates, steroids, valporate, vigabatrin and tiagabine. The composition can be used in the manufacture of a medicament for the treatment of epilepsy, alcohol withdrawal, tremor, bipolar disorder, mania, obsessive compulsive disorder, panic disorder, anxiety, anxiety disorders, depression, migraine, headache, pain disorders, ischemia and head trauma.
Patent NZ-522351-A (NZ)
Title: Berley dispenser
Inventor: POTTS BEVAN RICHARD
IPC: A01K97/02
Filed: 2002-11-04
Abstract: A berley dispenser consisting of a heavy frame element (1) provides support for a mesh over-bag (2). The bag has an opening at at least one end allowing berley to be positioned within the hollow interior of the frame element, which may take the shape of a coil. A drawstring closure (3), attachable to the support line, may be provided to effect closure of the bag opening. The dispenser has an open structure which resists the influence of current on the dispenser.
Patent NZ-523762-A (NZ)
Title: A method of constructing a rail track on a track- receiving concrete slab
Inventor: ERSHAM JEAN
IPC: E01B9/62
Filed: 2003-01-22
Abstract: A method of constructing a rail track on a track- receiving concrete slab (1) that is provided with channels (4) serving to receive the rails (2) of the rail track, said method being characterized in that after the concrete forming the slab (1) has set, the following steps are conducted: the stretches of rail (2) are put in place above the channels (4) in the slab (1), each rail having a foot (P) coated with a casing (3) of resilient material whose thickness is such that the foot (P) as coated with its casing (3) is slightly wider than the channel (4); the foot (P) as coated with its casing (3) is inserted into the channel (4) by force, the shape of the channel (4) being suitable for reacting to the compression forces from the resilient material of the casing (3) with a reactive force tending to hold the rail (2) at the bottom of the channel (4); the empty volume situated in the top portion of the channel (4) on either side of the rail (2) is filled with resin (5) that seals the installation.
Patent NZ-525555-A (NZ)
Title: Pyrimidine derivatives used as Neurokinin 1 (NK1) receptor antagonists
Inventor: STADLER HEINZ
IPC: A61P35/00
Filed: 2001-11-13
Abstract: Pyrimidine derivative compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof are disclosed, wherein R1 is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, -S-lower alkyl, -S(O)2-lower alkyl, -N(R)-(CH2)n-N(R)2, -O-(CH2)n-N(R)2, -N(R)2, or a cyclic tertiary amine which may contain one additional heteroatom, selected from N, O or S, and wherein this group may be connected with the pyrimidine ring via the linker -O(CH2)n-; R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R3 and R3' are independently from each other, hydrogen or lower alkyl; R4 is independently from each other halogen, trifluoromethyl or lower alkoxy; X is-C(O)N(R) or -N(R)C(O)-; Y is -O-, -S-, -SO2-, or -N(R)-; n is 1, 2, 3 or 4; and m is 0, 1 or 2. These pyrimidine derivatives have a good affinity to the NK1 receptor and are suitable in the treatment of diseases, related to this receptor.