baber/WOPTO huggingface dataset:
Patent WO-2020163685-A1 (WO)
Title: Méthodes de traitement d'hémorragie intracrânienne et d'évaluation d'efficacité
Inventor: YUE PATRICK
IPC: C12N9/64
Filed: 2020-02-07
Abstract: La présente invention concerne des compositions et des méthodes utiles pour évaluer l'efficacité hémostatique chez un patient ayant souffert d'une hémorragie intracrânienne alors qu'il suit un traitement anticoagulant par un inhibiteur du facteur Xa (fXa). La méthode peut consister à administrer au patient un dérivé de fXa qui a une activité catalytique réduite par comparaison avec la protéine fXa de type sauvage, qui est apte à se lier à l'inhibiteur du facteur Xa et ne peut pas s'assembler en un complexe de prothrombinase; la méthode consiste également à obtenir un échantillon de sang à partir du patient suite à l'administration; et à mesurer une activité anti-fXa dans l'échantillon, l'activité anti-fXa reflétant l'efficacité hémostatique chez le patient. Une fois l'évaluation effectuée, des interventions médicales appropriées peuvent être mises en œuvre.
Patent WO-2020172360-A1 (WO)
Inventor: TEMPLIN JONATHAN
IPC: G16H10/60
Filed: 2020-02-20
Abstract: Cette invention concerne des procédés, des systèmes et des dispositifs pour l'évaluation diagnostique d'un répondant. Les techniques d'évaluation diagnostique peuvent utiliser un modèle de classification pour caractériser de multiples dimensions du répondant. Le modèle de classification peut caractériser le répondant comme ayant un attribut (par exemple, une variable non observée) qui est mesuré par un ou plusieurs résultats (par exemple, des variables observées). Les résultats peuvent être basés sur des réponses reçues en provenance du répondant sur des éléments sur une évaluation. Le modèle de classification peut également caractériser un ou plusieurs paramètres d'élément associés aux éléments de l'évaluation.
Patent WO-2020172423-A1 (WO)
Title: Stable anhydrous foaming and gelling hand soap concentrate and method of making same
Inventor: NAQVI SYED HUMZA
IPC: C11D3/10
Filed: 2020-02-20
Abstract: The invention relates to stable, anhydrous foaming hand soap concentrated formulation in solid forms.
Patent WO-2020176521-A1 (WO)
Title: Fibres à deux composants fibrillées et leurs procédés de préparation et d'utilisation
Inventor: POURDEYHIMI BEHNAM
IPC: D02G3/38
Filed: 2020-02-25
Abstract: La présente invention concerne de manière générale des tissus à microdeniers comprenant des fibres à deux composants fibrillées. Les fibres à deux composants peuvent être fibrillées mécaniquement par hydroenchevêtrement, l'énergie d'hydroenchevêtrement étant suffisante pour la fibrillation ainsi que l'enchevêtrement ou la liaison des fibres. Les fibres à deux composants peuvent avoir une configuration de type île-en-mer. Les tissus à microdeniers peuvent être tissés, tricotés ou non tissés. Un tissu non tissé fabriqué à partir des fibres à deux composants peut être formé soit par liage par filage, soit par l'utilisation de fibres discontinues à deux composants formées en une bande par l'un quelconque parmi plusieurs moyens et liées de manière similaire à celles utilisées pour les bandes de filaments filés-liés.
Patent WO-2020180727-A1 (WO)
Inventor: LIOT CAROLINE
IPC: A61K39/395
Filed: 2020-02-28
Abstract: L'invention concerne des méthodes de traitement ou d'inhibition de la croissance d'une tumeur, les méthodes comprenant la sélection et l'administration à un sujet en ayant besoin d'une quantité thérapeutiquement efficace d'un inhibiteur de la voie de l'IL-4/IL-13 et d'une quantité thérapeutiquement efficace d'un inhibiteur de mort programmée 1 (PD-1). Dans certains modes de réalisation, l'inhibiteur de la voie IL-4/IL-13 améliore l'efficacité antitumorale du blocage de PD-1.
Patent WO-2020185744-A1 (WO)
Title: Electrostatic chuck heater resistance measurement to approximate temperature
Inventor: JING CHANGYOU
IPC: G01R19/10
Filed: 2020-03-10
Abstract: A controller including a voltage sensor coupled to a heater trace integrated in an electrostatic chuck, the voltage sensor configured to sense a voltage difference across the heater trace, wherein the heater trace is associated with a heater zone. The controller including a current sensor coupled to the heater trace and configured to sense a current in the heater trace. The controller including a resistance identifier configured to identify a resistance of the heater trace based on the voltage difference and the current that is sensed. The controller including a temperature correlator configured to approximate a temperature of the heater zone based on the resistance and a correlation function of the heater trace. The correlation function uses a temperature coefficient of resistance of the heater trace.
Patent WO-2020191241-A1 (WO)
Inventor: LIU DAVID
IPC: C12N9/22
Filed: 2020-03-19
Abstract: The present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The nucleotide change can include a single-nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to a strand of the targeted endogenous DNA sequence to be edited, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incoporated into the target DNA molecule. Also disclosed herein are various methods that leverage prime editing, including treating trinucleotide repeat contraction diseases, installing targeted peptide tags, treating prion disease through the intallation of protection mutations, manipulating RNA-encoding genes for the installation of RNA tags for controlling the function and expression of RNA, using prime editing to construct sophisticated gene libraries, using prime editing to insert immunoepitopes into proteins, use of prime editing to insert inducible dimerization domains into protein targets, and delivery methods, among others.
Patent WO-2020205608-A1 (WO)
Title: Uses of androgen receptor antagonists and jnk pathway inhibitors, and pharmaceutical compositions related thereto
Inventor: MORENO CARLOS SANCHEZ
IPC: A61K31/4375
Filed: 2020-03-27
Abstract: This disclosure relates to methods of treating or preventing cancer and pharmaceutical compositions related thereto. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an androgen deprivation therapy in combination with a JNK pathway inhibitor to a subject in need thereof. In certain embodiments, androgen receptor antagonist is enzalutamide. In certain embodiments, the JNK pathway inhibitor is bentamapimod. In certain embodiments, the cancer is prostate cancer.
Patent WO-2020210149-A1 (WO)
Title: Broad and long-lasting influenza vaccine
Inventor: ROBERTS SCOT
IPC: C12N15/44
Filed: 2020-04-06
Abstract: Provided herein are monovalent pharmaceutical compositions (vaccine compositions) and methods for inducing a multi-arm (mucosal, humoral and cell-mediated) immune response and extended seroprotection of at least 12 months post vaccination against influenza virus.
Patent WO-2020210419-A1 (WO)
Inventor: SULLIVAN SCOTT
IPC: B05C17/06
Filed: 2020-04-09
Abstract: A stencil and method of using the stencil made of a heat and flame resistant material and which includes an opening or openings defining an artwork image. The stencil is used in conjunction with a heat source such as from a flame of a torch to burn or char the artwork image defined by the stencil onto a substrate, and without degradation of the stencil.
Patent WO-2020223025-A1 (WO)
Title: Polymer oil blend
Inventor: QI LUQING
IPC: A61K8/92
Filed: 2020-04-16
Abstract: A polymer oil blend is provided comprising (a) a cosmetically acceptable long chain hydrophobic ester oil, wherein the cosmetically acceptable long chain hydrophobic ester oil comprises aliphatic C >12-24  alkyl triglycerides; (b) a thickening polymer powder, wherein the thickening polymer powder comprises: (i) 96 to 99.9 wt%, based on weight of the thickening polymer powder, of structural units of C 4-8  alkyl (meth) acrylate monomer; (ii) 0.1 to 2 wt%, based on weight of the thickening polymer powder, of structural units of (meth)acrylic acid monomer; (iii) 0 to 2 wt%, based on weight of the thickening polymer powder, of structural units of multi-ethylenically unsaturated crosslinking monomer; and (c) a silica powder; and wherein the weight ratio of silica powder/thickening polymer powder is ≥ 0.25. Also provided are personal care compositions containing same and methods of using same.
Patent WO-2020226884-A1 (WO)
Inventor: HUANG FENG
IPC: H04L9/32
Filed: 2020-04-20
Abstract: Described embodiments provide systems and methods for securing offline data for shared accounts of a shared computing device. Cache files can be generated for a plurality of users of an application executable on the device to store user data corresponding to individual users of the application. An encryption key can be generated for one or more of the cache files and the encryption key can be associated with at least one user of the application. The encryption key can be associated with a user identifier so that the encryption key is not accessible by other users of the computing device. The user data can be encrypted in one of the cache files with the encryption key. The encrypted user data can be presented to a user via the shared computing device based on receipt of a user identifier that enables access to the encryption key.
Patent WO-2020219565-A1 (WO)
Title: Selectively openable closure for a container
Inventor: FRENCH JORDAN
IPC: B65D43/26
Filed: 2020-04-22
Abstract: A closure for a container, and more specifically a closure that is selectively openable and/or lockable providing, for example, one or more child resistant opening features is disclosed.
Patent WO-2020219995-A1 (WO)
Title: System and method for solar cell array diagnostics in high altitude long endurance aircraft
Inventor: LOTFY NADER
IPC: G05F1/67
Filed: 2020-04-24
Abstract: In one embodiment a solar array circuit is provided capable of being utilized in a high altitude long endurance aircraft. The solar array circuit includes a solar array string having a plurality of solar cells connected in series. Multiple solar array strings are connected in parallel to form a solar array channel. A plurality of MOSFET switches are provided, each being connected in series to an output of the plurality of solar cells of a solar array string so as to allow each of the plurality of solar strings within the solar array channel to be independently disconnected and connected within the solar array channel.
Patent WO-2020226971-A1 (WO)
Inventor: LIN YE
IPC: H01M4/86
Filed: 2020-04-29
Abstract: A method for determining the oxygen surface exchange property of a material in a solid oxide fuel cell. The method begins by first receiving a data stream comprising of continuous weight measurements of the material and time measurements of when the continuous weight measurements of the material are taken. While receiving the data stream an oxygen concentration test is performed which involves: flowing a primary gas flow onto the material while simultaneously increasing the temperature of the primary gas flow to a set temperature, flowing the primary gas flow onto the material at the set temperature, and stopping the primary gas flow and starting a secondary gas flow at the set temperature. This data stream is then displayed analyzing the weight change of the material over time.
Patent WO-2020242913-A1 (WO)
Inventor: MYKKANNEN JENNI
IPC: C12Q1/70
Filed: 2020-05-22
Abstract: During manufacture of replication-deficient viral gene therapy vector, random mutation or other events may produce undesirable replication-competent virus ("RCV"). Viral gene therapy vector manufacturers thus assay for the presence of contaminating RCV by assaying for serial infection, i.e., transducing target cells with the viral vector, and then lysing the transduced cells, and then mixing the lysate with live assay cells, and then microscopically observing the assay cells to visually determine whether they have been infected with virus. We have tested various alternative approaches, and surprisingly found that droplet digital PCR is not only faster than the prior art approach, but is also over an order of magnitude more sensitive, able to detect, for example, in 3 x 1010 assay cells, as few as seven (7) replication competent adenoviruses ("RC").
Patent WO-2020243264-A1 (WO)
Inventor: Boluriaan Said
IPC: H04R1/08
Filed: 2020-05-28
Abstract: Certain aspects of the present disclosure provide an apparatus. The apparatus comprises a support structure comprising at least one microphone sensor, and a first material layer disposed adjacent to the support structure, wherein a first layer of air is formed between the first material layer and the support structure, the first layer of air being adjacent to the microphone sensor. In certain aspects, multiple material layers may be used, each of the material layers forming a layer of air. For instance, the apparatus may also include a second material layer disposed adjacent to the first material layer, wherein a second layer of air is formed between the first material layer and the second material layer.
Patent WO-2020243479-A1 (WO)
Inventor: SPANGLER JAMIE
IPC: C12N15/63
Filed: 2020-05-29
Abstract: L'invention concerne de nouveaux agents de liaison bispécifiques et des procédés de construction et d'expression de ceux-ci. Les procédés de construction de l'agent de liaison bispécifique décrivent généralement une combinaison d'une stratégie d'assemblage de boutons dans des trous et d'une approche d'expression de Fab à chaîne unique pour générer une plateforme de liaison bispécifique modulaire.
Patent WO-2020247644-A1 (WO)
Inventor: CHOU JOEY
IPC: H04W24/02
Filed: 2020-06-04
Abstract: Systems, devices, and techniques for self-organizing networks (SON) including automatic neighbor relation (ANR) management and physical cell identifier (PCI) configuration aspects are described. A described ANR technique includes enabling, by an ANR management function, a distributed ANR function at a node such as a gNB; receiving, by the ANR management function, a notification from the distributed ANR function indicating a change of a neighbor cell relation in a cell; and performing, by the ANR management function, an action based on the notification. Performing the action can include setting a blacklist of one or more neighbor cell relations, setting a whitelist of one or more neighbor cell relations, or changing one or more attributes of one or more neighbor cell relations.
Patent WO-2020263567-A1 (WO)
Inventor: SEGUIN KATHERINE
IPC: C12N15/31
Filed: 2020-06-10
Abstract: Novel insecticidal proteins that are toxic to lepidopteran pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms to express the insecticidal proteins. The recombinant organisms or compositions containing the recombinant organisms or the insecticidal proteins alone or in combination with an appropriate agricultural carrier can be used to control lepidopteran pests in various environments.
Patent WO-2021003025-A1 (WO)
Inventor: NIKULIN ILIA ANDREYEVICH
IPC: C03B17/06
Filed: 2020-06-18
Abstract: Glass forming devices can comprise a first outer surface of a first wall, a second outer surface of a second wall, and a heater. Glass forming methods can comprise flowing a first stream of molten material over a first outer surface of the first wall and flowing a second stream of molten material over a second outer surface of the second wall. Methods can further comprise drawing a glass ribbon. Methods can also comprise heating the first wall with the heater to heat an inner portion of the first stream of molten material contacting the first outer surface of the first wall to maintain a viscosity of the inner portion of the first stream of molten material below the liquidus viscosity of the first stream of molten material.
Patent WO-2021055062-A1 (WO)
Title: Printers with transparent displays
Inventor: MALLESHAPPA RANGANATH
IPC: B41L39/02
Filed: 2020-06-22
Abstract: An example printer includes a housing and a print mechanism disposed within the housing. The print mechanism is to print a document to a print medium. The example printer further includes a transparent display positioned at the housing. The transparent display is to display information related to operation of the print mechanism. The transparent display is positioned to allow viewing of the print mechanism from outside the housing.
Patent WO-2020264318-A1 (WO)
Inventor: SPANGLER JAMIE
IPC: A61K39/395
Filed: 2020-06-26
Abstract: This document relates to methods and materials for targeted expansion of regulatory T cells (T RegS ). For example, one or more single-chain antibody/cytokine fusion proteins (immunocytokines) that can bind to a heterotrimeric receptor including an interleukin-2 receptor-α (IL-2Rα) polypeptide, an interleukin-2 receptor-β (IL-2Rβ) polypeptide, and a common gamma chain (γc) polypeptide ( e.g. , an IL-2Rα/IL-2Rβ/γc polypeptide complex) can be administered to a mammal to stimulate T RegS  within the mammal to reduce or eliminate an immune response in that mammal. In some cases, methods and materials that can be used to treat a mammal having a condition that can benefit from reducing or eliminating an immune response within the mammal are provided. For example, one or more single-chain immunocytokines that can bind to an ΙL-2Rα/ΙL-2Rβ/γc polypeptide complex can be administered to a mammal having a condition that can benefit from reducing or eliminating an immune response to treat the mammal.
Patent WO-2021015988-A1 (WO)
Title: Multi-tenant wireless network management based on traffic monitoring
Inventor: SOROND MARIAM
IPC: H04L12/24
Filed: 2020-07-14
Abstract: Arrangements involving a multi-tenant network management system are presented. A first virtual wireless network can be operated as part of a wireless network. The first virtual wireless network can be mapped to a first set of operating level-of-service parameters. A second virtual wireless network can also be operated as part of the wireless network on behalf of a third entity. The second virtual wireless network can be mapped to a second set of level-of-service operating parameters. A traffic monitoring system may be present that monitors and compiles traffic-related statistics for the first virtual wireless network and the second virtual wireless network separately. A virtual network management system can use a machine learning arrangement to determine how to modify properties of the first virtual wireless network to satisfy the first set of level-of-service operating parameters.
Patent WO-2021045942-A1 (WO)
Inventor: AZHAKANADAM KASIMALAI
IPC: C12N15/32
Filed: 2020-08-26
Abstract: La présente invention concerne des promoteurs ayant une utilité particulière pour entraîner l'expression, spécifique des racines, de gènes hétérologues qui confèrent des caractéristiques agronomiques, horticoles et/ou pesticides améliorées à une plante transgénique donnée. La présente invention concerne également des molécules d'ADN comprenant les promoteurs de l'invention et des tissus végétaux transformés contenant des molécules d'ADN comprenant un promoteur de l'invention fonctionnellement lié à un gène ou à des gènes hétérologues, et des semences correspondantes.
Patent WO-2021041514-A1 (WO)
Title: Procédés de fabrication de membranes et de films polymères
Inventor: FREEMAN BENNY
IPC: B01D39/14
Filed: 2020-08-26
Abstract: L'invention concerne des procédés de dépôt de film induit par non-solvant pour la fabrication de films polymères, de membranes à matrice mixte et de revêtements, intermédiaires, stratifiés et membranes composites associés. Des nanoparticules, telles que des nanoparticules à structure organométallique, peuvent être dispersées dans les films polymères. L'invention concerne également des systèmes de film et des membranes polymères pour des procédés de transport ou de séparation de ressources, de minéraux et d'ions contenus dans des gaz et de liquides.
Patent WO-2021050598-A1 (WO)
Title: Positional synchronization of virtual and physical cameras
Inventor: KERR JOEL
IPC: G06F3/01
Filed: 2020-09-09
Abstract: A device for positional synchronization of virtual and physical cameras may include a processor configured to determine a first position of a physical camera relative to another electronic device in a physical environment. The processor may be configured to initiate positioning of a virtual camera in a second position within a computer-generated environment, wherein the second position relative to a representation of the person in the computer-generated environment coincides with the first position. The processor may be configured to receive an image frame captured by the physical camera and a virtual image frame generated by the virtual camera. The processor may be configured to generate a computer-generated reality image frame that includes at least a portion of the image frame composited with at least a portion of the virtual image frame.
Patent WO-2022046125-A1 (WO)
Inventor: BIGGS NATHANIEL MARC
IPC: H04N21/854
Filed: 2020-09-10
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating variants/versions of an audio digital component and providing a particular variant for displaying/playing on a client device. Methods can include receiving a request to generate a template for an audio digital component. Based on information in the request, the template can be generated. A first set of media data items can be linked to static media data blocks in the template. Based on the template, variants of the audio digital component can be generated and for each, media data items can be linked to the dynamic media data blocks. A request for the audio digital component can be received from a client device. A set of signals can be obtained from the client device, based on which, a particular variant of the audio digital component can be provided for display on the device.
Patent WO-2021055285-A1 (WO)
Title: Clamp for telecommunications cable
Inventor: DE ZITTER SAMORY
IPC: H01B11/00
Filed: 2020-09-14
Abstract: Cable clamp for a telecommunications cable. The cable clamp includes a band that includes a generally looped portion that can be wrapped around a portion of a telecommunications cable and another structure, and a pair of tail portions extending from the generally looped portion. One of the tail portions is fixed to a worm screw housing and the other tail portion is configured to advance relative to the worm screw housing upon rotation of the worm screw.
Patent WO-2021080879-A1 (WO)
Title: Methods and systems for controlling tintable windows with cloud detection
Inventor: BROWN STEPHEN CLARK
IPC: G01J1/02
Filed: 2020-10-16
Abstract: Methods and systems for controlling tintable windows based on cloud detection.