baber/WOPTO huggingface dataset:
Patent CR-20170383-A (CR)
Title: Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123
Inventor: BARRIERE CÉDRIC
IPC: C07K16/28
Filed: 2016-01-22
Abstract: La presente invención se refiere a una proteína de unión semejante a anticuerpo que se une específicamente a CD3 y que se une específicamente al menos a un antígeno adicional, por ejemplo CD123. La presente invención también se refiere a una proteína de unión semejante a anticuerpo que se une específicamente a CD123 y que se une específicamente al menos a un antígeno adicional. La invención se refiere además a anticuerpos anti-CD3 y anticuerpos anti-CD123.
Patent CR-20170559-A (CR)
Title: Peptidos lipidados resistentes a proteasas.
Inventor: BEDNAREK MARIA A;
IPC: C12Q1/37
Filed: 2016-06-09
Abstract: La presente invención proporciona péptidos resistentes a proteasas, métodos de preparación de tales péptidos, así como composiciones que comprenden péptidos resistentes a proteasas y métodos de tratamiento que utilizan tales péptidos. Una combinación de lipidación de determinados residuos de aminoácidos y sustitución de aminoácidos funcionalizados con alfa-metilo en lugar de aminoácidos naturales para producir péptidos resistentes a proteasas.
Patent CR-20210285-A (CR)
Title: Arylsulfonylpyrolecarboxamide derivatives as kv3 potassium channel activators
Inventor: RASMUSSEN LARS KYHN
IPC: C07D417/12
Filed: 2019-10-30
Abstract: The present invention provides novel compounds which activate the Kv3 potassium channels. The compounds have the structure (Formula I), Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and use of the compounds to treat disorders responsive to the activation of Kv3 potassium channels.
Patent EC-SP003685-A (EC)
Title: Formulaciones orales de liberacion controlada
Inventor: LEDERGERBER DOROTHEA
IPC: A61K9/20
Filed: 2000-09-28
Abstract: Una composición farmacéutica capaz de liberar una dosis terapéuticamente efectiva del agente activo, por ejemplo rivastigmina, de una manera controlada en el tiempo.
Patent EC-SP003742-A (EC)
Title: Cristales de inhibidor del intercambiador de sodio-hidrogeno tipo i
Inventor: BROSTROM LYLE R
IPC: C07D403/04
Filed: 2000-10-27
Abstract: Cristales inhibidores del NHE-1, procedimientos de uso de tales cristales inhibidores del NHE-1 y composiciones farmacéuticas que contienen tales cristales inhibidores del NHE-1. Los cristales inhibidores del NHE-1 son útiles para reducir la lesión en los tejidos originada por una isquemia en los tejidos.
Patent EC-SP045092-A (EC)
Title: Amidas de acido antranilico y su uso como inhibidores de tirosina-cinasa del receptor de vegf
IPC: A61K31/44
Filed: 2004-05-03
Abstract: La invención se refiere a derivados de amida de ácido antranílico de la fórmula (I), en donde R1 representa H o alquilo inferior, R2 representa H o alquilo inferior, R3 representa perfluoroalquilo inferior, y X es O u S, o un N-óxido o su tautómero, a sales de dichas amidas de ácido antranílico, sus N-óxidos y sus tautómeros; a procesos para su preparación, su aplicación para el tratamiento del cuerpo del ser humano o animal, su uso - solos o en combinación con uno o más de otros compuestos farmacéuticamente activos - para especialmente el tratamiento de una enfermedad neoplástica, tal como una enfermedad tumoral, de retinopatía o degeneración macular relacionada con la edad; a un método para el tratamiento de dicha enfermedad en animales, especialmente seres humanos, y al uso de dichos compuestos - solos o en combinación con uno o más de otros compuestos farmacéuticamente activos - para la fabricación de una preparación farmacéutica para el tratamiento de una enfermedad neoplástica, de retinopatía o degeneración macular relacionada con la edad.
Patent EC-SP055917-A (EC)
Title: Derivados de diazepanes útiles como inhibidores de lfa
Inventor: OBERHAUSER BERNDT
IPC: C07D401/14
Filed: 2005-07-15
Abstract: Se describen diazepanes farmacéuticamente activos, por ejemplo, útiles para el tratamiento de trastornos o enfermedades mediadas por interacciones de LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/CAM-3 o LFA-1/JAM-1.
Patent EC-SP066384-A (EC)
Title: Proceso para la preparación de 4-amino - 3- quinolincarbonitrilos
Inventor: BOSCHELLI DIANE HARRIS
IPC: C07D495/04
Filed: 2006-02-17
Abstract: Esta invención describe un proceso para la preparación de 4-amino-3-quinolincarbonitrilo, que comprende combinar un compuesto de amina con un ácido cianoacético y un catalizador ácido, para producir una cianoacetamida; condensar la cianoacetamida con una anilina opcionalmente hasta tetra-sustituida, en un solvente alcohólico y un ortoformiato de trialquilo, para producir una 2-amino-2-cianoacrilamida; combinar la 3-amino-2-cianoacrilamida con oxicloruro de fósforo en acetonitrilo, butironitrilo, tolueno o xileno, opcionalmente en presencia de un catalizador, para producir el 4-amino-3-quinolincarbonitrilo, y también describe un proceso para la preparación del 7-amino-tieno[3,2-b]piridin-6-carbonitrilo, que comprende combinar un 3-amino-tiofeno con un cianoacetamida y ortoformiato de trialquilo en un solvente alcohólico, para obtener una 3-amino-2-cianoacrilamida; y combinar la 3-amino-2-cianoacrilamida con oxicloruro de fósforo y acetonitrilo, butironitrilo, tolueno o xileno, opcionalmente en presencia de un catalizador, para producir el 7-amino-tieno[3,2-b]piridin-6-carbonitrilo; y también describe un proceso para la preparación del 4-amino-3-quinolincarbonitrilo que comprende: combinar un compuesto de amina con ácido cianoacético con un reactivo de acoplamiento de péptidos, para obtener una suspensión; se filtra la suspensión; para producir la cianoacetamida; se condensa la cianoacetamida con una anilina opcionalmente hasta tetra-sustituida, con un solvente alcohólico para producir un 4-amino-3-quinolincarbonitrilo; y la invención describe un proceso para obtener una cianoacetamida.
Patent EC-SP066541-A (EC)
Title: Nuevos derivados de piridazin-3(2h)-ona
Inventor: DAL PIAZ VITTORIO
IPC: C07D413/04
Filed: 2006-05-03
Abstract: La presente invención se refiere a nuevos derivados de pirazidin-3(2H)-ONA, que tienen la estructura química de la fórmula general (I); así como procedimientos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapéutico como inhibidores de fosfodiesterasa 4.
Patent EC-SP077978-A (EC)
Title: Anticuerpos monoclonales anti-trkb y usos de los mismos
Inventor: GILL DAVINDER S
IPC: C07K16/28
Filed: 2007-12-03
Abstract: La presente invención proporciona anticuerpos monoclonales para el TrkB humano. En algunas modalidades los anticuerpos de la invención se unen y activan el TrkB humano. En algunas modalidades de la invención los anticuerpos son selectivos para el TrkB humano ya que no se unen (ni activan) el TrkA humano o el TrkC humano. En algunas modalidades los anticuerpos monoclonales presentan reactividad cruzada con TrkB murina. Versiones humanizadas o figuradas de los anticuerpos también son consideradas. Las composiciones farmacéuticas que comprenden los anticuerpos de la invención son proporcionados como métodos para preparar los anticuerpos y métodos de la invención para utilizar los mismos con propósitos de tratamiento, detección y purificación.
Patent EC-SP930897-A (EC)
Inventor: RODRIGUEZ FERRE JOSE MANUEL
IPC: A63H3/36
Filed: 1993-01-07
Abstract: The articulated structure for dolls or puppet bodies of the invention consists of a structure or skeleton-like framework in which the various elements and members which comprise it are connected with one another at their ends by means of link connections (8,9) which in combination with the structure of the referenced ends constitute ball and socket articulations. The link connections are formed by two spheres 8a connected by a radial appendix 8b, over which is injected the integrating material making up the semispherical catches 9, constructed in the ends of the elements or members of the skeleton-like framework. The improvements are applicable in the manfuacture of articulated structures for dolls which permit stable and voluntary positioning of their members or connecting parts. <IMAGE>
Patent EC-SP961783-A (EC)
Title: Derivados de pirimidindiona pirimidintriona triacindiona tetrahidro- quinazolindion como antagonistas adrenoceptores case ran 4013/26
Inventor: MORGANS DAVID
IPC: C07D403/10
Filed: 1996-06-06
Abstract: El invento se refiere a nuevos antagonistas 1-adrenoceptores de la fórmula I (gráfico), en donde: R1 es acetilamino, amino, ciano, trifluoroacetilamino, halo, hidro, hidroxilo, nitro, metilsulfonilamino, 2-propiniloxilo, un grupo elegido entre (C1-6) alquilo, (C3-6) cicloalquilo, (C3-6)-cicloalquil (C1-4) alquilo, (C1-6) alquiloxilo, (C3-6) cicloalquil-oxilo, (C3-6) cicloalquil (C1-4) alquiloxilo y (C1-4) alquiltio (cuyo grupo está opcionalmente sustituido adicionalmente por uno a tres tomos de halo) o un grupo elegido entre arilo, aril-(C1-4) alquilo, heteroarilo, heteroaril(C1-4)= alquilo, ariloxi, aril (C1-4)-alquiloxilo, heteroariloxilo y heteroaril (C1-4)-alquiloxilo (cuyo arilo y heteroarilo están opcionalmente sustituidos adicionalmente por uno a dos radicales elegidos independientemente entre halo y ciano); R2 es ciano, halo, hidro, hidroxilo, o un grupo elegido entre (C1-6) alquilo y (C1-6) alquiloxilo (cuyo grupo está opcionalmente sustituido adicionalmente por uno a tres tomos de halógeno); R3 y R4 son ambos hidro o metilo o juntos son etileno y R5 es un grupo elegido de las fórmulas (a), (b), (c) y (d) (gráfico), en donde X es C(O), CH2 o CH(Oh); Y es CH2 O CH(OH); Z es N o C(R), en donde R9 es hidro, (C1-6) alquilo o hidroxilo R6 es hidro, un grupo elegido entre (C1-6) alquilo, (C3-6) cicloalquilo, (C3-6) cicloalquil (C1-4) alquilo (cuyo grupo está opcionalmente sustituido adicionalmente por uno o tres tomos de halo) o un grupo elegido entre arrilo, heteroarilo, aril (C1-4) alquilo y heteroaril (C1-4) alquilo (cuyo arilo y heteroarilo están opcionalmente sustituidos adicionalmente por uno o tres radicales elegidos entre halo, ciano, (C1-6) alquiloxilo, (C1-6)-alquilo y arilo; R7 es (C1-6) alcanoilo, carbamoilo, ciano, di(C1-6)alquilamino, halo, hidro, hidroxilo, hidroximinometilo, (C1-6) alquil-sulfonilo (C1-4) alquiltio, un grupo elegido entre (C1-6) alquilo (C3-6) cicloalquilo, (C1-6) alquiloxilo y (C1-6) alquil-oxi (C1-4) alquilo (cuyo grupo está opcionalmente sustituido adicionlmente por uno a tres radicales elegidos entre halo, hidroxilo o (C1-6) alquiloxilo o un grupo elegido entre arilo, heteroarilo, aril(C1-4) alquilo y heteroaril (C1-4) alquilo cuyo arilo y heteroarilo están opcionalmente sustituidos adicionalmente por uno a tres radicales elegidos entre halo, ciano (C1-6) alquiloxilo, (C1-6)alquilo y arilo o R7 y R9 juntos son tetrametileno; y cada R8 es independientemente hidro, hidroxilo, metilo, etilo; y sus sales farmacéuticamente aceptables y N-óxidos.
Patent EC-SP993009-A (EC)
Title: Procedimiento mejorado para la preparacion de aductos de bases de schiff de aminas con o-hidroxialdehidos y composiciones de materia basadas en los mismos
Inventor: CLARK MICHAEL THOMAS
IPC: C07D213/66
Filed: 1999-06-08
Abstract: Se describe un procedimiento mejorado para la preparación de productos finales aductos de condensación de bases 5 de Schiff cuyos componentes incluyen una proteína que tiene una actividad beneficiosa en animales y un o-hidroxi aldehido aromático, el cual comprende la puesta en contacto de los componentes anteriormente mencionados en un entorno acuoso a un pH de 7,0 o superior para formar una mezcla de 10 reacción en condiciones eficaces para llevar dicha reacción de condensación sustancialmente hasta su finalización, eliminando entre aproximadamente 97,0% y aproximadamente 99,9% en peso, preferentemente entre aproximadamente 98,0% y aproximadamente 99,0% en peso del agua presente durante 15 dicha reacción de condensación, siendo compatible con el mantenimiento de la integridad de los reactivos de condensación y del producto final aducto, y para asegurar un porcentaje de conversión en dicho producto final aducto de condensación, es decir con un rendimiento resultante de 20 dicho producto final aducto de condensación igual o superior al 98,5% en peso, preferentemente igual o superior al 99,5% en peso respecto al peso de los reactivos. Los o-hidroxi aldehídos aromáticos preferidos incluyen: o-vainillina, aldehído salicílico 2,3-dihidroxibenzaldehído, 25 2,6-dihidroxibenzaldehído, hidroxi-3-etoxibenzaldehido o piridoxal. Se pueden utilizar una amplia gama de proteinas. El procedimiento proporciona unos rendimientos superiores al 90% y la conversión sustancilamente cuantitativa del aldehído y la proteína en el aducto de condensación.
Patent FI-20022157-A (FI)
Inventor: HEIKKILAE SIMO
IPC: E04F13/08
Filed: 2002-12-05
Abstract: The invention relates to wall or ceiling panels of buildings, comprising a metallic outer surface plate (3a) and a metallic inner surface plate (3b), and heat insulation (6) provided therebetween. The groove (7) of the tongue and groove joint comprises folds (4a, 4b) extending inwards from the surface plates at the panel edge, as outwardly extensions thereof first bends (9a, 9b) and further inwardly first inner flanges (11a, 11b). The tongue (8) comprises bead strips (5a, 5b) extending outwards from the surface plates at the panel edge, as extensions thereof in the inward direction second bends (10a, 10b) and further in the outward direction second inner flanges (12a, 12b). <IMAGE>
Patent FR-1066148-A (FR)
Inventor: WOLFSON HENRY
IPC: H01L21/60
Filed: 1952-06-06
Granted: 1954-06-02
Abstract: 914,592. Semi-conductor devices. STANDARD TELEPHONES & CABLES Ltd. April 17, 1959 [April 23, 1958], No. 13142/59. Class 37. [Also in Group XXII] A semi-conductor element is mounted in a casing comprising a metal part including a rim fitting into a channel in another metal part of different hardness. After assembling the parts with the rim in the channel, the housing is sealed by plastic deformation in the cold of one of the parts. In one embodiment the softer part is a threaded copper bolt 4 with an annular channel 3. Sealing is effected by deforming the edges of the channel over the flanged edge of steel cylinder 6. External connection to the upper face of the semi-conductor element is provided by a stranded copper or silver wire (Fig. 4) with a conical solid end engaging the element. The wire leaves the housing through a metal tubule 8 in a sintered glass bead 7. The wire, which is deformed and solid where it passes through the tubule, is pinch sealed therein in vacuo or in an inert atmosphere, the abutting surfaces of the wire and tube being coated with a low-melting metal, e.g., tin, to facilitate sealing. In an alternative arrangement, the wire consists of a solid-headed part 11b of silver and an upper part 11a of tinned copper, the abutting solid ends 13a, 13b having the cross-sections shown to facilitate evacuation of the housing prior to sealing. During the pinch sealing process, the two parts of the wire are joined and sealed within the tube. In a modification of the above device, the copper base is internally threaded for mounting on a cooling block and silverplated to allow etching of the mounted semiconductor element without copper contamination of the etchant. A transistor is also described, comprising two sub-assemblies 5, 6, 7, 8 of the construction shown in Fig. 1, sealed in annular grooves on opposite faces of an apertured plate carrying the semi-conductor element. In another arrangement (Fig. 3) comprising copper base-plate 4 and steel cap 2, connections are sealed through the base-plate by glass-metal seals, as shown in Fig. 3a, the edges of apertures 10 being deformed in the cold state to fix the seals.
Patent GB-1024473-A (GB)
Abstract: 1,024,473. Photo-electric measuring devices. ZAVODY V. I. LENINA PLZEN NARODNI PODNIK. Oct. 22, 1962 [Oct. 20, 1961], No. 39831/62. Heading G1A. The dimension or position of an object 2 in a direction parallel to a diffuse planar light source 1 of greater area than the object and emitting light of a specific wavelength is given by the output from a photo-electric cell 3a as modified by the interposition of the object 2 between the cell 3a and the source 1, the cell 3a being responsive only to light of said specific wavelength. As shown light from the source 1 is focused on to the cell 3a by an optical system comprising a lens 3b and filter 3c and the photo-cell 3a forms part of a bridge circuit 4 whose output controls a servo motor 7 which adjusts the position of the combined photo-cell and optical system unit 3 in a direction parallel to the surface of the source 1 to reduce the output from the bridge circuit to zero, the resultant position of the unit 3 as given by a remote indicator coupled to the servo motor 7 by a selsyn 5 giving the required object data. Alternatively the position of the unit 3 may be adjusted manually or the unit 3 may be stationary, the required data being then given by the output from the bridge circuit 4.
Patent GB-1050312-A (GB)
IPC: C07C51/487
Abstract: 1,050,312. Purifying terephthalic acid. INSTITUT FRANCAIS DU PETROLE, DES CARBURANTS ET LUBRIFIANTS. May 12, 1966 [May 13, 1964], No. 20092/65. Heading C2C. Terephthalic acid is purified by forming an aqueous solution of the dialkali or diammonium salt, treating with an oxidizing agent and evaporating at least 1% by volume of the water present, followed by acidification.
Patent GB-1052843-A (GB)
IPC: C08L61/20
Abstract: 1,052,843. Coated paper. ARAKAWA RINSAN KAGAKU KOGYO KABUSHIKI KAISHA. Aug. 9, 1963 [Aug. 16, 1962], No. 31571/63. Heading B2E. [Also in Divisions B5, C3 and D2] As a surface coating agent for paper there may be used a composition comprising (a) starch, (b) a water-soluble co-condensate of 1 mol of acetone and 0.1-06 mol of urea or ethylene urea or melamine, or a mixture of these, with formaldehyde, prepared i.p.o. an alkaline catalyst below 70‹C., and optionally (c) a salt of a vinyl acetate/maleic anhydride copolymer and an alkaline substance. Preferably there are 0.25-5 p.b.w. each of (b) and (c) per 100 p.b.w. of starch (see Division C3).
Patent GB-1110156-A (GB)
Abstract: 1,110,156. Vibration testing. TEXTRON ELECTRONICS Inc. 2 June, 1966 [21 June, 1965], No. 24721/66. Heading H4D. In a vibration testing system in which the exciter 22 (Fig. 1) is driven by a signal produced by combining the outputs of a bank of AGC amplifiers 16 fed from respective ones of a bank of bandpass filters 15 supplied from an audio frequency random noise generator 10 and the gains of the amplifiers 16 controlled by the outputs of respective ones of a further bank of bandpass filters 30 (similar to 15) supplied with input signals derived from an accelerometer 24 coupled to the exciter 22 to control the acceleration spectral density characteristic so that it is independent of resonance effects in the system or specimen as described in Specification 927,195, compensation for the effect of the mechanical impedance of the specimen under test is effected by additionally controlling the gains of the amplifiers 16 by signals derived from a force transducer 35 mounted on the exciter 22. The signals from the latter are converted to the same frequency range as utilized for the forward exciter drive signals and the control signals from the accelerometer by means of a balanced modulator 38 fed from the local oscillator 13 the output of the latter being supplied via a bank of adjustable phase shifters 40 and a bank of adjustable attenuators 42 and thence via respective ones of a bank of summing amplifiers 29 together with the signals derived from the accelerometer to the bank of band-pass filters 30.
Patent GB-1225497-A (GB)
IPC: B44B3/00
Filed: 1967-06-23
Abstract: 1,225,497. Milling screwthreads; grinding; turning. S. J. ROYLE. 10 June, 1968 [23 June, 1967], No. 29183/67. Headings B3D, B3K and B3T. Mechanism for adjustable-rate axial feed of a rotary spindle B comprises an angularly adjustable setting rod F which lies in a plane intersecting the spindle axis at a variable angle depending on the setting of the rod, the spindle B being axially fed at a rate determined by the setting of the rod F by means wherein relative motion between the rod F and a bearing member E slidable therealong causes displacement of the spindle. As shown, the spindle B is rotatably and slidably supported in a bearing A on a base K which is attached to a surface grinding or milling machine table to enable a screwthread to be cut on a workpiece J by a rotating cutter or grinding wheel G. The spindle B is driven through bevel gears H from a drive spindle C mounted in a U-bracket M carried by the spindle B, the setting rod F is pivoted at the centre of curvature of an arcuate scale D1 on a quadrant member D which includes a bar D2 slidable in the U-bracket M and has a nut portion engaging screwthreads on the drive spindle C, and the bearing member E is releasably positioned in an arcuate slot E1 in the base K to allow the rod F to be positioned anywhere on the scale D1 by means of a clamp D3. When the drive spindle C is rotated by means of a star wheel C1 the spindle B and workpiece are rotated and the nut advances along the spindle C to displace the quadrant member D transversely of the spindle B so that the bar F slides through the bearing member E to displace the quadrant member D, bracket M and spindle B together with the workpiece J longitudinally of the spindle axis. In Fig. 2 (not shown), the drive spindle C is driven by an electric motor through a belt drive. The setting rod F and bearing member E may be curved so that threads of varying pitch can be produced. In another embodiment, Fig. 3 (not shown), two setting rods permit selective movement of the spindle in either axial direction, and there is provided a scroll-cutting attachment comprising a turntable which is driven through bevel gears from the spindle and moves with the spindle in relation to a fixed tool. In a further embodiment, Fig. 4 (not shown), the setting bar is carried by a graduated turn-table connected by pivot means to a fixed base.
Patent GB-1225676-A (GB)
IPC: H05K3/07
Filed: 1968-04-05
Abstract: 1,225,676. Spark - erosion. INTERNATIONAL COMPUTERS Ltd. 2 April, 1969 [5 April, 1968], No. 16445/68. Heading B3V. [Also in Divisions C7 and H1] In removing, by electrolysis or by spark erosion, parts of a layer of electrically conductive material from an electrically insulating substrate so as to manufacture circuit components comprising a pattern of the conductive material, a group of electrodes is relatively moved across the layer and the electrodes are selectively energized during the movement to produce the pattern. The Figures illustrate removing copper 11B from an electrically insulating substrate 11A within a tank 10 by means of electrodes 25 supported in a line in a block 16. The electrode block is moved across the substrate by a drive 19 and the electrodes are selectively energized, e.g. under control from a computer. Liquid is pumped between the electrodes and substrate, by means of a pump 13 and slotted pipe 24, and is recirculated to the pump by a pipe 15. The pipe 15 may collect liquid from a slot (not shown) in the tank bottom or may drain liquid which overflows a weir (not shown. The electrodes 25 are insulated at 26 and are spaced from one another. Fig. 3 (not shown) illustrates an embodiment where electrodes (25A) in a second line span the spaces between the electrodes 25. In an alternative form of the apparatus, the electrode block 16 is fixed and the tank 10 moved beneath it. In electrolytic removal, an electrolyte and unidirectional current are used. In spark erosion, a dielectric liquid and a pulsating current are used.