Patent SG-11201909311T-A (SG)
Title: Triterpene saponin synthesis, intermediates and adjuvant combinations
Inventor: CHAN AMANDA
IPC: C07H15/256
Filed: 2018-04-13
Abstract: AcylChain Trtferpene (Ouillaic Acid) erori•oherf Tritocritarkte OH Me HO O MG H HO HO OHHO 0 HO Ma f+4 Hall t4e e Linear relras.ssucheride 11S-21.Api f (-6510 CIS4141 (-36%) HO wog FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PCT omit IIl °nolo mu °mu Imo oimIE (10) International Publication Number WO 2018/191598 Al C (51) International Patent Classification: A61K 31/704 (2006.01) CO7H 1/08 (2006.01) A61K 39/39 (2006.01) CO7H 15/256 (2006.01) (21) International Application Number: PCT/US2018/027462 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/485,260 13 April 2017 (13.04.2017) US 62/488,287 21 April 2017 (21.04.2017) US 62/489,546 25 April 2017 (25.04.2017) US (71) Applicant: ADJUVANCE TECHNOLOGIES, INC. [US/US]; 16 West 22nd Street, 6th Floor, New York, NY 10010 (US). (72) Inventor: GIN, David, Y. (deceased). (72) Inventors: CHAN, Amanda; 40 Rainbow Crest, Hopewell Junction, NY 12533 (US). GARDNER, Jeffrey; 116 W22nd St, Apt 1, New York, NY 10011 (US). NORDSTROEM, Lars; 450 West 152nd St. #52, New York, NY 10031 (US). WALKOWICZ, William; 684 Lin- coln PI, Apt 1, Brooklyn, NY 11216 (US). MARTIN, J., Tyler; 5200 Quarry Ledge Road, Roca, NE 68430 (US). (74) Agent: STRAIN, Paul, D.; Strain & Strain PLLC, 1455 Pennsylvania Ave, NM., Suite 400, Washington, DC 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — (54) Title: TRITERPENE SAPONIN SYNTHESIS, INTERMEDIATES AND ADJUVANT COMBINATIONS 1-1 (57) : The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates © thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.