Patent SG-11201903414S-A (SG)
Title: Crystalline form of (1r,2r)-2-[4-(3-methy1-1h-pyrazol-5-yl)benzoyl]-n-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexanecarboxamide
Inventor: PETTERSEN ANNA
IPC: C07D231/50
Filed: 2017-10-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111H11110111011101111111111011110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/078097 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: (74) Agent: LEESE, Mathew, Paul; Milstein Building, Granta A61K 31/4155 (2006.01) CO7D 417/12 (2006.01) Park, Cambridge Cambridgeshire CB21 6GH (GB). C07D 231/40 (2006.01) C07D 487/04 (2006.01) C07D 231/44 (2006.01) CO7D 498/04 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7D 231/50 (2006.01) A61P 9/00 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 413/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/EP2017/077602 HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 27 October 2017 (27.10.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/414,109 28 October 2016 (28.10.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Sodertalje (SE). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fk FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventor: PETERSEN, Matilda, Angelica; AstraZeneca MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Pepparedsleden 1, 43183 Molndal (SE). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — KM, ML, MR, NE, SN, TD, TG). = = (54) Title: CRYSTALLINE FORM OF (1R,2R)-2-[4-(3-METHY1-1H-PYRAZOL-5-YL)BENZOYI]-N-(4-0X0-4,5,6,7- - TETRAHYDROPYRAZOLO[1,5-A]PYRAZIN-3-YL)CYCLOHEXANECARBOXAMIDE = = Fig ure 0.5 - -- .. = = = _ 0.0 1 = = = ..., -0.5 = = = -1.0 1-1 - 1 3 IN 01 0 GC -2.0 ' , T , , IN 0 0 50 100 150 200 250 300 Exo up Temperature :(\"C) Universal V4.5A 00 1-1 0 (57) : A crystalline form of (1R,2R)-244-(3-Methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5- ei a]pyrazin-3-yl)cyclohexanecarboxamide, pharmaceutical compositions containing it and its use in therapy. [Continued on next page] WO 2018/078097 Al MIDEDIMOMMIDIREIEHMONIMIEHMEMOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply patent (Rule 4.17(H)) for and be granted a Published: — with international search report (Art. 21(3))