baber/WOPTO huggingface dataset:
Patent PT-644944-E (PT)
Inventor: CARTER BARRIE J
IPC: A61K38/00
Filed: 1993-06-02
Abstract: Described herein are constructions of recombinant DNA comprising modified adeno-associated virus (AAV) DNA sequences capable of functioning as a eukaryotic expression vector for expressing foreign DNA sequences using a novel transcription promoter comprising the termini of AAV DNA. It is shown that expression of a test reporter gene can be obtained from this vector in mammalian cells. It is further shown that this combination of vector and promoter can be used to introduce and express a human gene and correct a genetic defect in human cells resulting from malfunction of the mutant endogenous gene. Further, the vector can be used to correct the genetic defect by expressing a modified version of the human gene consisting of a fusion of part of the said gene and a synthetic sequence contained in the vector. <IMAGE>
Patent PT-852580-E (PT)
Inventor: MCGARRITY JOHN
IPC: C12R1/01
Filed: 1996-08-30
Abstract: A process for the preparation of dihydroxypyrimidine derivatives of the general formula:in which R1 and R2 are identical or different and are a hydrogen atom, aryl group, or a C1-C4-alkyl group or an aryl group, starting from a compound of the general formula:in which R2 has the meaning mentioned above and R3 is -CN or COOR4, in which R4 is a C1-C4-alkyl group.
Patent PT-916646-E (PT)
Inventor: ZHAO CHEN
IPC: C07D209/44
Filed: 1994-09-26
Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof. <CHEM>   <CHEM>   <CHEM>
Patent PT-943730-E (PT)
Inventor: WIEBE KURT
IPC: D21F7/08
Filed: 1999-03-11
Abstract: A multilayer porous fabric which comprises a porous core fabric (10) provided with hook means (11), and at least one layer of pre-needled nonwoven fibrous batt (12A,12B) attached by entanglement onto the hook means (11) by pressing the core fabric and batt together. The entanglement is sufficient to anchor the batt reliably to the core fabric, so that the multilayer fabric is ready for use without further processing. The porous core fabric may be formed by weaving or as an extruded sheet, with a plurality of suitably located hook means structures on at least one of its surfaces. The hook structures engage with and entangle sufficient fibers from the pre-needled nonwoven batt to provide adequate attachment preventing the batt from separating from the core fabric enabling the multilayer fabric to be handled before use, for example for installation in a papermaking machine press section. The batt is pre-needled to a desired density before attachment to the core fabric. In many circumstances, compressive loads applied to the porous fabric serve to enhance and improve the level of entanglement of the batt onto the hook means. <IMAGE>
Patent SG-68889-G (SG)
Title: Divisible polyacrylate-based tablet
IPC: A61K9/26
Filed: 1989-10-11
Abstract: A novel divisible delayed release pharmaceutical tablet, wherein the rate of release of active ingredient is independent of the size and nature of the total surface area, and the fragments of which have the same characteristics of release of active ingredient as the undivided tablet.
Patent IE-850192-L (IE)
Title: Tumor specific monoclonal antibodies.
IPC: C07K16/00
Filed: 1985-01-25
Abstract: This invention relates to monoclonal antibodies produced by hybridoma or transformed B-cell lines derived from B-cells of cancer patients actively immunized with autologous tumor antigen. These monoclonal antibodies can be used in both diagnostic procedures and therapy for human cancers. This invention also relates to diagnostic procedures and therapeutic approaches using these monoclonal antibodies.
Patent IE-860205-L (IE)
Title: Preparation of 4,4-dialkyl-2-azetidinones.
IPC: C07D309/12
Filed: 1986-01-24
Abstract: Pharmaceutically acceptable salts of [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfoox y)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy] acetic acid and a process useful in the preparation of such salts are disclosed herein.
[US4638061A]
Patent IE-840238-L (IE)
Title: Liquid cleansing compositions
IPC: C11D3/06
Filed: 1984-02-01
Abstract: Hair or body shampoo compositions having an upper aqueous layer and a lower aqueous layer which are temporarily dispersible one in the other upon agitation of the composition and wherein each layer is miscible with water in substantially all proportions. The upper layer has dissolved therein at least one detergent. The lower layer contains sodium hexametaphosphate dissolved therein. The compositions have cleansing properties and impart a conditioning effect.
Patent IE-900279-L (IE)
Title: Fire isolation device
IPC: A62C2/06
Filed: 1990-01-25
Abstract: A fire isolation device having a valve designed to close after a given temperature has been reached by a fusible nose member in the form of a sleeve of fusible material. The device has a passageway therethrough and a self-closing valve member having a poppet and a seat disposed in the passageway with the poppet being biased toward the seat to a valve closed position. At least one aperture through the nose member provides for continuous fluid flow through the device around the poppet and the seat. The nose member is positioned to hold the valve in an open position against the bias on the poppet. The seat has a flow path on its outer end dimensioned to fit the nose member and a flow path towards its inner end larger in diameter than the nose member in an area occupied by the aperture to permit flow therethrough when the nose member holds the valve in an open position. The nose member is made of a material designed to melt in the neighborhood of 700 DEG  F. when the fire isolation device is exposed to 2000 DEG  F. for 15 minutes, for example, after which it will collapse into the larger diameter permitting the bias to close the valve. The nosse member is designed to melt prior to an attached component in order to prevent fluid leakage at the component. The remainder of the parts of the device are made of a higher temperature resistant material. In a second embodiment a bi-directional device is provided in which valve and nose members are positioned in both ends thereof.
Patent IE-810321-L (IE)
Title: Pyrrolidines for stabilization of polyolefins
IPC: C08L23/18
Filed: 1981-02-18
Abstract: A stabilized polyolefine-based polymeric composition is disclosed characterized in that it contains as stabilizer an organic polyamine having the general formula: <IMAGE> (I) wherein R1, R2, R3 and R4 are equal to or different from each other and are an alkyl group having from 1 to 4 carbon atoms; R5 is hydrogen or an alkyl group having from 1 to 4 carbon atoms; A is an alkylene group having from 2 to 10 carbon atoms; B is a divalent aliphatic, cycloaliphatic, aromatic or alkylaromatic radical, which can contain hetero atoms such as O, S, N and P either in the chain or as side substituents; and N IS A WHOLE NUMBER BETWEEN 2 AND 1000. The organic polyamine has an inherent viscosity of between 0.01 and 1 dl/g, and is employed in an amount equal to or less than 5% by weight. The stabilized polymeric composition may be in the form of fibers, filaments, films or other shaped articles. The organic polyamines themselves are novel, as are certain difunctional amine intermediates. Processes for preparing same are also disclosed.
[US4104248A]
Patent IE-45117-L (IE)
Title: Fluid machine for generating rotary motion
IPC: F03C1/30
Filed: 1977-02-21
Abstract: A machine for generating motion is constructed like an epicyclic gear, with the intermediate gears mounted on a cylindrical core between the inner and outer gears. The intermediate gears are alternately axially offset and the core provides circumferential undulating guides for pistons that slide in the inner and outer gear teeth so that they pass over and under the intermediate gears. The pistons and intermediate gears divide the space between inner and outer gears into separate chambers to which pressure fluid can be selectively admitted to achieve rotation.
[US4102614A]
Patent IE-42304-L (IE)
Title: Fluid flow control valves
IPC: F16K7/12
Filed: 1976-02-26
Abstract: 1509552 Valves SAUNDERS VALVE CO Ltd 25 Feb 1976 [6 March 1975] 9452/75 Heading F2V In a fluid-flow control valve, e.g. a diaphragm valve, comprising an axially-movable operating spindle 13, that part of the spindle which lies externally of the valve casing is protected from grit, water, &c. by a pair of telescoped sleeves 18, 23 having sealing means 24 therebetween. The annular space defined between the spindle and the sleeve 18 is packed with grease for lubricating the spindle, the grease pack being covered by a felt washer 21 which also functions to wipe surplus grease off the spindle when it moves in the valve-opening direction. The sleeve 18 is of plastics material and may be brightly coloured to readily indicate the position of the valve closure element.
[GB1509552A]
Patent IE-800532-L (IE)
Title: Insulation of pipes
IPC: B29C48/09
Filed: 1980-03-14
Abstract: Metal e.g. steel pipe insulated with foamed polyurethane plastic is made in a multi-stage continuous process in which an inner layer of polyurethane plastic is foamed on the pipe and at least partially cured to form low-density foam having high heat insulating capacity, and an outer layer of polyurethane plastic is foamed on the inner layer to provide a foam layer of higher density, the outer layer having a density at least 25% greater than that of the adjacent inner layer, the thickness of the outer layer being 5 to 30% of the total thickness of the foamed insulation. The inner layer may be subdivided into two or more layers having different physical properties. A common protective layer e.g. polythene/butyl adhesive tape, epoxy, heat actuated adhesive or asphalt may be first applied to the pipe. An outer protective layer of paper, butuminous inactive or plastic e.g. polythene, polypropylene or epoxy may be applied. The plastic may be heat shrinkable.
[GB2046865A]
Patent IE-870681-L (IE)
Title: N-benzoyl-n-(heterocyclylphenyl) ureas
IPC: C07D231/14
Filed: 1987-03-16
Abstract: Novel substituted N-(heterocyclic-substituted phenyl)-N min -benzoylureas, processes for producing these compounds, compositions thereof and the use of the compounds for the control of pests.
Patent IE-820752-L (IE)
Title: Computer control system
IPC: G06F11/20
Filed: 1982-03-29
Abstract: A processor control system for controlling items of hardware includes pairs of processors associated with the hardware items. One processor of each pair operates the process or processes for controlling the associated hardware, while the other processor of each pair operates other processes. In the event of a fault in one processor the processes on that processor are transferred to spare processors and the hardware control process is transferred to the other processor of the pair. This arrangement makes more effective use of standby processing capacity.
[US4628508A]
Patent IE-44943-L (IE)
Title: Tumour antigens.
IPC: C07F9/10
Filed: 1977-05-03
Abstract: TUMOR ANTIGEN AND PROCESS FOR THE PREPARATION THEREOF of the disclosure: The present invention relates to tumor antigens which can be obtained from tumor cells by treating tumor cells with a short chain synthetic lysolecithin analog, separating the cell residue and recovering the supernatant; the invention relates furthermore to immunotherapeutic medicaments against tumor affections which consist of or contain the tumor antigens obtained according to the above process.
[CA1077840A]
Patent FI-822338-L (FI)
Inventor: MONTABERT ROGER
IPC: B25D9/12
Filed: 1982-06-30
Abstract: A power cylinder of a hydraulic percussion implement, in whose bore a ram with an enlarged piston head is vertically reciprocable to strike a tool at the lower end of the bore, has a control chamber above the piston head alternately communicating with the high-pressure side and the low-pressure side of a source of hydraulic fluid, an annular recess in the bore being permanently or intermittently connected to high pressure acting upon the underside of the piston head. An annular drainage chamber formed by the bore at a lower level, disposed above an oil seal, collects liquid leaking down from that recess and returns it to the source. A pneumatic buffer lies in or communicates with that drainage chamber for absorbing hydraulic shocks generated when the ram strikes the tool.
Patent FI-831971-L (FI)
Inventor: TSAU JOSEF HENG-KO
IPC: C07K5/075
Filed: 1983-06-01
Abstract: Aspartyl dipeptide sweetener sulfate and alkyl sulfonate salts are described which have high thermal stability and a fast rate of dissolution in aqueous media. These salts can be almost universally substituted in place of sugar and are effective in baking and cold drink applications.
Patent IE-34445-L (IE)
Title: Phenylsulphonyl - 2 - imino - imidazolidines
IPC: C07D233/46
Filed: 1970-08-07
Abstract: 1-(P-Ureidoalkylphenylsulfonyl)-2-imino-imidazolidines and 1-(p-thioureidoalkylphenylsulfonyl)-2-imino-imidazolidines being substituted at the imidazolidine and at the 3-position of the ureido moieties are prepared; these compounds and the pharmaceutically acceptable acid addition salts thereof have hypoglycemic activity; pharmaceutical compositions comprising said compounds and methods of producing hypoglycemic effects in mammals are provided; an illustrative embodiment is 1-[p-(2-(3-n-butyl-2-thioureido)-ethyl)-phenylsulfonyl]-2-imino-3-n-bu tyl-imidazolidine.
[US3725430A]
Patent IE-39511-L (IE)
Title: Aminomethanephosphonic acid derivatives as plant growth¹regulators.
IPC: A01N57/20
Filed: 1974-06-18
Abstract: 1471754 Plant-growth regulant BAYER AG 18 June 1974 [19 June 1973] 26945/74 Heading C1B [Also in Division C2] A plant-growth-regulating composition contains, as active ingredient, an aminomethanephosphonic acid derivative of the general Formula (I) in which R is an NH 2 group or an -#NH 3 X<SP>(-)</SP> radical wherein X<SP>(-)</SP> is one equivalent of an anion of an organic or inorganic acid, and (i), if R is NH 2 , then each of R<SP>1</SP> and R<SP>11</SP>, which may be identical or different, is one equivalent of a protonized nitrogen base, the base being selected from isopropylamine, diethylamine, triethylamine, butylamine, ethylenediamine, pyrrolidine, imidazole, piperidine and morpholine, or of a compound which is formed by protonization of glycine or glycine ethyl ester, or hydrogen, provided that R<SP>1</SP> and R<SP>11</SP> cannot simultaneously be hydrogen, or (ii), if R is an -#NH 3 X<SP>(-)</SP> radical, R<SP>1</SP> and R<SP>11</SP> are both hydrogen, in admixture with a solid or liquefied gaseous diluent or carrier or in admixture with a liquid diluent or carrier containing a surface active agent. Specified anions X<SP>(-)</SP> are the chloride, bromide, sulphate, methylsulphonate, nitrate, acetate, dichloroacetate and trichloroacetate anions. The compositions may also contain other active agents and the active ingredients I may also be applied to a plant or plant habitat either alone or in admixture with a diluent or carrier to regulate the growth of the plants. Specification 1,437,952 is referred to.
[GB1471754A]
Patent IE-811335-L (IE)
Title: Pour-on antihelminth composition
IPC: A61K9/06
Filed: 1981-06-16
Abstract: The present invention relates to non-aggressive pour-on composition for combating helminthic infestations in a non-human animal, said composition comprising an anthelminthic amount of tetramisole and/or levamisole, a carboxylic acid and a di(lower alkyl) ester of a dicarboxylic acid.
Patent IE-39611-L (IE)
Title: Charge coupled device
IPC: H01L29/10
Filed: 1974-07-15
Abstract: A two-phase ion implantation process to form a charge coupled device comprising forming an electrically insulating layer on a semiconductor substrate, forming a metal layer on said insulating layer, forming a photo-resist layer on said metal layer, selectively etching areas of the photo-resist layer and the metal layer therebelow to provide spaced electrodes, subjecting the gaps between the electrodes to an ion implantation beam directed at one corner of each gap at a relatively small angle to the plane of the substrate to cause ions to be implanted below one edge region of each electrode, subjecting the gaps to a second ion implantation beam directed at an oblique angle to the substrate which is larger than the angle of said first ion beam to cause ions to be implanted in the substrate beneath each gap but spaced from the edge of the gap which lies opposite to the said one edge, removing the photo-resist layer, forming a second electric insulating layer over the said electrodes and over the bottom and sides of the gaps, forming a second group of electrodes on the second insulating layer over each gap between adjacent electrodes. The ions of the first ion beam are of the same type as are contained in the substrate. The ions of the second beam are of the opposite type to those contained in the substrate. In a preferred embodiment, the ions of the first beam are phosphorus ions, the ions of the second beam are boron ions, and the semiconductor substrate is silicon. (From US3914857 A) [FR2246068A1]
Patent IE-891588-L (IE)
Title: Method of and compositions for reducing wear on surfaces¹subjected to frictional forces
IPC: C10M173/00
Filed: 1989-05-17
Abstract: A method and composition for reducing wear on surfaces subjected to frictional forces. The lubricating compositions can be applied in a carrier which may be organic or inorganic in nature. They function by providing a regime in which multimolecular layers are adsorbed onto the surfaces to be protected, thus enabling comparatively thick protective films to be built up on the surfaces subjected to frictional wear. The molecules having this property are essentially single or condensed unsaturated ring systems which comprise at least one six-membered unsaturated heterocyclic ring comprising at least one heterocyclic moiety which acts as a hydrogen acceptor and a hydrogen donor moiety. If substituents are present they should not create steric hindrance and/or render the molecule so basic or acidic as to alter the steric geometry of the molecule as to prevent the interaction of the active groups.
[WO8911518A2]
Patent IE-801628-L (IE)
Title: Safety belt stop
IPC: A44B11/08
Filed: 1980-08-05
Abstract: A stop (9) for an inertia-reel safety belt is clamped on the diagonal run (6) of the safety belt adjacent to the upper guide (4) and transmits the self-reeling force of the safety belt to an upper anchorage thus relieving pressure upon a user's chest. The stop comprises a body (10) in which a slide (30), carrying a knurled roller (50) is slidable between a clamped position in which the roller engages the run (6) of the belt thus clamping the stop (9) to the belt, and a released position in which the roller (50) is free to rotate and the stop (9) is therefore slidable along the run (6) of the belt.
Patent IE-38256-L (IE)
Title: Vinylphosphoric acid diester amides
IPC: A01N57/30
Filed: 1973-09-18
Abstract: O-(1-halophenyl-2-chloro)-vinyl-phosphoric acid diester-amides of the formula IN WHICH R is alkyl of 1 to 12 carbon atoms, haloalkyl of 1 to 4 carbon atoms, alkoxyalkyl of 1 to 6 carbon atoms in each alkyl or alkoxy moiety, alkenyl of 2 to 6 carbon atoms, or phenyl, phenylalkyl, cycloalkyl, cycloalkenyl or cycloalkenalkyl optionally substituted by halogen or alkyl of 1 to 4 carbon atoms, R' and R'' each independently is hydrogen, lower alkyl, alkenyl or phenylalkyl, or R' and R'' together with the nitrogen atom form a heterocyclic ring, Hal is chlorine or bromine, and N IS AN INTEGER FROM 1 TO 5, WHICH POSSESS INSECTICIDAL, ACARICIDAL, FUNGICIDAL AND BACTERICIDAL PROPERTIES.
[US3878269A]
Patent IE-791971-L (IE)
Title: Organic diamine compounds
IPC: A61P3/10
Filed: 1979-10-17
Abstract: The compounds for use as oral hypoglycemic agents are of the formulae: …<CHEM>… …<CHEM>… …<CHEM>… …<CHEM>… …<CHEM>… or …<CHEM>… wherein X is hydrogen, fluorine, chlorine, bromine, nitro, cyano, lower alkyl or lower alkoxy, X being other than hydrogen in formula (I);… Y and Y min are each amino, lower N-monoalkylamino, lower N,N-dialkylamino, pyridylamino, pyrrolidino, piperidino, homopiperidino, morpholino, thiomorpholino, 2,3-dihydroisoindolyl and 1,2,3,4-tetrahydroisoquinolyl; and… Z is oxygen or sulfur. Several methods for the preparation of these compounds are described; e.g. alpha , alpha min -dibromo-o-xylene by reaction with piperidine gives 1,1 min -[1,2-phenylene-bis-(methylene)]bispiperidine. …<??>Novel compounds claimed are: those of formula (I) wherein X is other than hydrogen or methyl, or wherein Y is pyridylamino and Y min is other than pyridylamino; and the compounds of formulae (IV) and (VI). Compositions claimed comprise an effective blood sugar lowering amount of a compound of formulae (I) to (VI) and a carrier material. 
[EP0010896A1]
Patent IE-40249-L (IE)
Title: Calcining calcium sulphate dihydrate
IPC: C04B11/02
Filed: 1974-11-06
Abstract: 1488665 CaSO 4 .2H 2 O calcination; gypsum kettles BPB INDUSTRIES Ltd 31 Oct 1974 [27 Nov 1973] 54940/73 Heading ClA Calcium sulphate dihydrate is calcined by supplying heat to the calcination vessel, both indirectly through the external walls, and directly via the introduction of non-reactive hot gases into the interior of the calcining mass through a tube extending generally downwardly from the top of the vessel, which tube is provided with at least one opening in its lower part immersed in the calcining mass. The hot gas introduced into the sulphate charge is preferably generated by combustion of a fuel, A typical apparatus of the invention is shown in Fig. 3; tubes 29 and 31 respectively carry the dihydrate into, and the hemihydrate out of, the calcination vessel, hot gas being supplied via (4), and leaving via (33) which leads to a cyclone or other dust collection apparatus (not shown); the solids collected at the cyclone &c., are returned to the calcination vessel via tube 36. If desired the injection of hot gas may be via a plurality of holes along a hollow stirrer shaft (38), or via a separate gas inlet tube (4) arranged concentrically around the stirrer shaft.
[GB1488665A]
Patent IE-872365-L (IE)
Title: 2-thiocycloalkyl-penems
IPC: A61P31/04
Filed: 1987-09-03
Abstract: Certain 2-(1-oxo-1-imino-1-thiacycloalkyl)thiopenem derivatives possessing broad, potent antibacterial activity are disclosed.
Patent IE-892539-L (IE)
Title: New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives¹thereof, a process for the preparation thereof, the use¹thereof as medicinal agents, pharmaceutical products and¹intermediates
IPC: C07D213/48
Filed: 1989-08-04
Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.