Patent SG-11202000132W-A (SG)
Title: Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment
Inventor: CANTLEY LEWIS C
IPC: A61K31/00
Filed: 2018-07-10
Abstract: International Patent Classification: C12Q 1/6886 (2018.01) A61K 31/00 (2006.01) (21) International Application Number: PCT/US2018/041480 (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/530,661 (72) Inventors; and (71) Applicants: CANTLEY, Lewis C. [US/US]; 43 Larch Road, Cambridge, Massachusetts 02138 (US). NGO, Bryan [US/US]; 418 E. 71st Street, Suite 61, New York, New York 10021 (US). BAKHOUM, Samuel F. [US/US]; 418 E. 71st Street, Suite 61, New York, New York 10021 (US). 10 July 2018 (10.07.2018) English English 10 July 2017 (10.07.2017) US (74) Agent: PERDOK, Monique M. et al.; Schwegman, Lund- berg & Woessner, P.A., P.O. Box 2938, Minneapolis, Min- nesota 55402 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: TARGETING CHROMOSOMAL INSTABILITY AND DOWNSTREAM CYTOSOLIC DNA SIGNALING FOR CAN- CER TREATMENT MDA-MB-231 80 p <0.01 H2030 80 re-- 60 E C 0 ° Q2 9) 40 w 20 cal 0 FIG, 2B®1 FIG. 2B-1 (57) : As described herein, chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combinations there- of are indicative of metastatic cancer. Methods and compositions are described herein that are useful for detection and treatment of patients with chromosomal instabilities such as chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combi- nations thereof. For example, some of the methods and compositions include use of kinesin-13 proteins such as Kif2b, MCAK/Kif2c, or KIF13A. The methods and compositions can also include inhibitors of STING, ENPP1, cGAS, NF-kB transcription factor p52, NF- kB transcription factor Re1B, or any combination thereof. Methods are also described for identifying compounds that are effective for treatment of cancer, including metastatic cancer. 60 20 0 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) v1E11111111111 viiliololoillEvivitivivitinuom (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/014246 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT [Continued on next page] WO 2019/014246 Al MIDEDIMOREHIHEIHNIIMMEMEIMEHHIME TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))