baber/WOPTO huggingface dataset:
Patent AU-2020325750-A1 (AU)
Title: Donor pigs for xenotransplantation
Inventor: TAN PAUL LIP JIN
IPC: A01K67/02
Filed: 2020-07-31
Abstract: The present invention relates to novel strains of pig that are highly suitable for xenotransplantation. The first novel pig strain lacks functional porcine endogenous retroviruses so is suitable as a donor for tissue and/or cell xenotransplantation into a human recipient. These pigs can also be used as a foundation pig for further manipulation, for example, by gene editing of xenoantigens to produce a second novel strain of pig that is not only free of infectious porcine retroviruses but is also free of the main xenoantigens responsible for hyperacute organ rejection. These pigs can be used for whole organ, tissue and/or cell transplantation into a human recipient. The present invention also relates to methods for selecting pigs that lack infectious porcine endogenous retroviruses, and their use for tissue and/or cell xenotransplantation into humans, and to methods of gene editing of xenoantigens of the selected pigs to further enhance the immunological quality of the donor organs, tissues and/or cells to avoid xenotransplant rejection.
Patent AU-2020326289-A1 (AU)
Title: Modified human variable domains
Inventor: SILVERMAN PETER BRIAN
IPC: C07K16/00
Filed: 2020-08-04
Abstract: The present invention provides polypeptides comprising modified human, humanized, or chimeric immunoglobulin heavy chain variable domains. Corresponding antibodies, variants, fragments, nucleic acids, vectors, phages, libraries, methods and kits are also provided.
Patent AU-2020349558-A1 (AU)
Title: Tensioned screen assembly
Inventor: COLGROVE JAMES R
IPC: B01D29/01
Filed: 2020-09-18
Abstract: A disclosed screen assembly (500) includes a frame (504) and a tensioned molded polyurethane screen (400a, 502) attached to the frame. The polyurethane screen has openings having a smallest length in a range from approximately 0.044 mm to approximately 4.0 mm. The screen assembly is configured to be removably attachable to an attrition screening apparatus. The frame has a perimeter that is a circle, square, rectangle, triangle, pentagon, hexagon, or other multi-sided polygon, and the screen may have similarly shaped apertures. The frame includes a support grid structure bounded by the perimeter and the screen may either be attached only to the perimeter of the frame, or may be attached to the perimeter of the frame and to one or more locations of the support grid structure. The screen includes uniaxial or biaxial reinforcement members (404a) that are integrally molded with the screen, and the tensioned screen may include tension along a direction that is parallel to, or perpendicular to, a direction of the reinforcement members. A disclosed method includes applying tension to a molded polyurethane screen and attaching the tensioned molded polyurethane screen to the frame.
Patent AU-2020372868-A1 (AU)
Title: High-resolution index (HRI) detector modules including capacitive sensors and related systems
Inventor: PROFETA JR JOSEPH ANTHONY
IPC: G01D4/02
Filed: 2020-10-26
Abstract: A high-resolution index (HRI) detector module for use with a meter including an HRI wheel therein having a modulator thereon is provided. The HRI detector module includes a plurality of capacitive sensors positioned on a printed circuit board (PCB). The plurality of capacitive sensors is configured to detect a change in capacitance caused by the modulator of the HRI wheel when the modulator enters into an electric field generated by the plurality of capacitive sensors. Related systems are also provided.
Patent AU-2020372912-A1 (AU)
Title: Dosing regimen of anti-CD27 antibodies for treatment of cancer
Inventor: CHARTASH ELLIOTT K
IPC: C07K16/28
Filed: 2020-10-29
Abstract: The present invention relates to methods of treating cancer by administering an anti-CD27 antibody as a monotherapy or as a part of a combination thereof.
Patent AU-2020387259-A1 (AU)
Title: Method for freezing neural cells
Inventor: HIRAMATSU SATOE
IPC: C12N1/04
Filed: 2020-11-19
Abstract: Provided is a method for freezing a cell aggregate that includes neural cells. Provided is a method for freezing a cell aggregate that includes neural cells having a three-dimensional structure, said method including the following step (1) and step (2): (1) a step in which, prior to freezing, the cell aggregate that includes the neural cells having the three-dimensional structure is brought into contact with a preservation liquid at 0°C to 30°C, and a preservation liquid-soaked cell aggregate is prepared; and (2) a step in which the preservation liquid-soaked cell aggregate that was obtained in step (1) is cooled at an average temperature reduction speed of 2-7°C/min, at least from a temperature that is approximately 5°C above the freezing point of the preservation liquid to a temperature that is approximately 5°C below said freezing point, and is thus made to freeze.
Patent AU-2020401135-A1 (AU)
Title: Combined extracorporeal and drug delivery system and method
Inventor: ZACHARIA JOHN RAMEZ
IPC: A61M1/16
Filed: 2020-12-09
Abstract: An extracorporeal and drug delivery system includes (i) a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including (a) an effluent pump for pumping effluent from the blood filter at an effluent flowrate, and at least one of (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, (c) a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or (d) a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; (ii) an infusion pump operable to deliver an intravenous ("IV") drug to the patient at an IV drug flowrate; and (iii) a coordinating logic implementor configured to adjust the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate.
Patent AU-2020408395-A1 (AU)
Title: Crystalline hydrobromide salt of a EZH2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer
Inventor: VERWIJS MARINUS JACOBUS
IPC: A61K31/5377
Filed: 2020-12-18
Abstract: The application relates to a crystalline form of N-((4,6-dimethyl-2- oxo-l,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H- pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3- carboxamide (Tazemetostat) hydrobromide, to methods for its preparation, and to pharmaceutical compositions comprising it. The compound is known to be an effective inhibitor of EZH2 (Enhancer of Zeste homologue 2) useful for the treatment of cancer.
Patent WO-2021232095-A1 (WO)
Title: A thermography inspection system and method of use thereof
Inventor: ERICHSEN JEFF
IPC: F16M11/12
Filed: 2021-05-19
Abstract: The present invention relates to a thermography inspection system and method of use thereof for remotely capturing thermal images of subjects or structures. The system includes at least one thermal image capturing device; at least one moveable mount for mounting the thermal image capturing device relative to a subject or structure and moving the thermal image capturing device relative to the subject or structure; and a remote controller operatively connected to the image capturing device and the moveable mount for at least receiving imaging data from the image capturing device and for remotely controlling operation of the image capturing device and the moveable mount.
Patent AU-2021200056-A1 (AU)
Title: Drive assembly
Inventor: JONES SIMON
IPC: F15B15/22
Filed: 2021-01-06
Abstract: A drive assembly comprising: an actuator including a housing having a first pressure 
chamber and a second pressure chamber; and a sleeve connector being connectable to the 
5 actuator and a conduit for discharging flowable material such that the actuator is configured 
to rotate the sleeve connector to control the direction of the conduit when discharging the 
flowable material; wherein a is slidably retained in the housing is configured to engage with 
the sleeve connector such that translation of the piston in a first direction between the first 
and second pressure chambers rotates the sleeve connector.
1/6 
00 
oo 
C'4 
Figure 1 
12001342_1I(GHMatters) P112171.AU
Patent AU-2021200256-A1 (AU)
Title: Sulfated Glycosaminoglycan Biomaterials as Proteoglycan Mimics
Inventor: JOZEFIAK THOMAS H
IPC: C08B37/00
Filed: 2021-01-15
Abstract: Polymer conjugates are provided that are capable of mimicking functions of natural 
proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates 
of the invention have utility in treating a subject suffering soft tissue conditions. Also 
provided are simple and scalable chemical processes for the preparation of the polymer 
conjugates of the invention.
Patent AU-2021201707-A1 (AU)
Title: Vibration Damping Device, Vibration Damping Method and Long-Span Bridge
Inventor: WANG ZHENGXING
IPC: E01D19/00
Filed: 2021-03-18
Abstract: The invention relates to the technical field of bridge vibration 
damping, and discloses a vibration damping device, a vibration damping 
method and a long-span bridge. The long-span bridge comprises: a 
plurality of piers arranged at intervals, each of which is provided with a 
cross beam; and a main beam, which is arranged on all the cross beams; 
wherein each pier is provided with one vibration damping device or two 
symmetrically arranged vibration damping devices. Each main beam 
vibration damping device comprises: a dowel bar, one end of which is 
rotatably connected with the bottom of the main beam outside the pier; an 
amplifying rod, whose middle part is rotatably arranged on the cross 
beam or the pier, comprising a connecting end and an amplifying end, 
and the connecting end is rotatably connected with the other end of the 
dowel bar; and a damper, one end of which is relatively rotatably 
arranged on the cross beam or the pier, and the other end is rotatably 
connected with the amplifying end. The vibration damping device can 
solve the problems of wind vibration and vehicle vibration, including 
vortex-induced vibration, of long-span bridges in the prior art under 
specific wind speed.  
(Fig 1.)
1/3 
A 
D 
E5 
Fig. 1 
A 
Eig- 2 
Fig. 2
Patent AU-2021203850-A1 (AU)
Title: A gaming machine and method for providing a feature game
Inventor: OLIVE SCOTT CHRISTOPHER
IPC: A63F13/55
Filed: 2021-06-10
Abstract: A gaming machine comprises a credit input mechanism configured to receive a physical item 
representing a monetary value for establishing a credit balance, the credit balance being increasable and 
decreasable based at least on wagering activity, a credit meter configured to monitor the credit balance, 
a manually operable player interface configured to, in accord with the wagering activity, initiate play of a 
base game, an electronic display having a display area, said display area having a plurality of display 
positions, memory storing data indicative of a set of symbols including a plurality of symbols having a 
particular characteristic, an evaluator configured to monitor the occurrence of a trigger event, and to 
trigger a feature game in response to the occurrence of a trigger event, said feature game comprising a 
variable number of free games, a free game counter configured to generate a count representing a 
number of free games remaining to be played, and wherein said evaluator is configured to revise said 
free game counter upon the occurrence of a defined outcome of a free game and to end the feature 
game when said count reaches a predetermined end count. During the feature game, the symbol 
selector is configured for each free game to: 1) hold at least some of the displayed symbols having the 
particular characteristic appearing on the display; 2) remove at least one of the displayed symbols 
without the particular characteristic from the display; 3) select randomly a replacement symbol from the 
set of symbols to replace a removed symbol without the particular characteristic; and 4) replace the 
removed said one of the displayed symbols without the particular characteristic with the selected 
replacement symbol. The outcome evaluator is configured to make an award upon a matrix of display 
positions being filled by symbols having the particular characteristic.
Patent AU-2021221607-A1 (AU)
Title: Tubes for medical systems
Inventor: STOKS ELMO BENSON
IPC: A61M16/08
Filed: 2021-08-25
Abstract: OF THE DISCLOSURE 
A medical tube transports gases to and/or from a patient. The medical tube has an 
elongate film spirally wrapped with an elongate reinforcing member, which bond to form a 
lumen. The elongate film has a profile such that the elongate film does not protrude into the 
lumen of the medical tube upon bending of the medical tube. The elongate reinforcing 
member can have a D-shaped cross section that can contribute to beneficial characteristics of 
the medical tube. The elongate reinforcing member can also have a circular cross section.  
-25-
Patent AU-2021233745-A1 (AU)
Title: Composition for anti-diabetes and anti-obesity comprising novel compound
Inventor: KIM JAE IL
IPC: A61Q19/06
Filed: 2021-03-11
Abstract: The present invention relates to a novel compound and a composition for an anti-diabetes and anti-obesity comprising same as an active ingredient. The compound according to the present invention or a pharmaceutically acceptable salt thereof selectively and specifically acts as an agonist of GPR39, activates the mechanism of glucose-dependent insulin secretion in pancreatic beta cells, and significantly increases glucose tolerance and an antidiabetic effect, and therefore can be used as a composition for improving, preventing, or treating diabetes. In addition, the compound according to the present invention or a pharmaceutically acceptable salt thereof acts on GPR39 so as to have lipolytic ability in adipocytes and adipose tissue, and therefore can be utilized as a composition for improving, preventing, or treating obesity.
Patent AU-2021244352-A1 (AU)
Title: Mill to whipstock connection system
Inventor: NGUYEN TUAN
IPC: E21B7/06
Filed: 2021-03-23
Abstract: A window cutting system includes a whipstock connector including an inner surface having at least one projection. A window mill is connected to the whipstock connector. The window mill includes a body having a connector member, a tip portion, a recess formed on an outer surface of the body, an axial passage extending from the connector member toward the tip portion and a radial passage extending outwardly from the axial passage. A pin is arranged in the radial passage and selectively extending into the recess.
Patent AU-2021276925-A1 (AU)
Title: Apparatus and method for non-invasive fractional treatment of skin tissue
Inventor: GERSHONOWITZ AMIKAM
IPC: A61B18/00
Filed: 2021-05-19
Abstract: The present invention relates to an apparatus for fractional treatment of skin tissue of a patient comprising a handpiece, at least one first electrode and at least one second electrode, arranged on a base plate for applying radio frequency energy, to at least one layer of the skin, wherein the apparatus is adapted to apply electrical energy to the skin tissue with a first pulse and a second pulse following the first pulse, with the first pulse being a low energy level pulse and the second pulse being a high energy level pulse having a higher energy level than the low energy level pulse.
Patent AU-2021326569-A1 (AU)
Title: Demand and supply planning method and demand and supply planning apparatus
Inventor: HAMAGUCHI KENICHI
IPC: H02J13/00
Filed: 2021-07-08
Abstract: This demand and supply planning method involves formulating a supply and demand plan that includes information identifying the operation, at every unit time, of energy generation units for generating energy while consuming fuel in a microgrid that is connected to an external energy supply system and that has the energy generation units, an energy storage unit, and a load unit, the method comprising: calculating an optimization problem relating to an objective function which includes a term relating to the fuel consumption in the microgrid and a term relating to energy transfer in the microgrid from the external energy supply system, by using restricting conditions on the relation between information relating to continuous operation time in at least one of the energy generation units at a starting clock time for formulating the supply and demand plan and a minimum operation time restriction on the energy generation unit; and outputting a supply and demand plan on the basis of the calculation result of the optimization problem.
Patent AU-2021328475-A1 (AU)
Title: Adeno-associated virus vectors for treatment of Rett syndrome
Inventor: O'BANION COLIN
IPC: C12N7/00
Filed: 2021-08-19
Abstract: The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in the
Patent AU-2021341903-A1 (AU)
Title: Valve for adjusting a fluid flow
Inventor: BUGATTI ANGELO
IPC: F16K5/10
Filed: 2021-09-13
Abstract: A valve (1) for adjusting a fluid flow comprises a valve body (10) and a flow adjustment assembly (18) sealingly housed in the valve body. The flow adjustment assembly comprises an external adjustment member (22, 26), which is operable for rotating between a valve opening position, in which it allows the fluid to pass from the inlet conduit (12) to the outlet conduit (14), and a valve closing position, in which it prevents the fluid from passing from the inlet conduit (12) and the outlet conduit (14) and an internal adjustment member (24), housed inside the external adjustment member (22, 26) and which is independently operable from the external adjustment member (22, 26) for adjusting the fluid passage port through the external adjustment member (22, 26).
Patent AU-2021343870-A1 (AU)
Title: Molten salts reactor systems for methane pyrolysis
Inventor: SPANU LEONARDO
IPC: B01J19/24
Filed: 2021-09-15
Abstract: A reactor system, which is active in pyrolyzing methane at effective conditions, comprising a molten salt medium and a reaction vessel, the molten salt being contained within the reaction vessel using various methods of catalyst distribution within the vessel such that when methane passes through the vessel, it comes into contact with said catalyst causing a pyrolysis reaction thereby producing molecular hydrogen with reduced carbon dioxide emissions. The catalyst may be placed within the reaction vessel either as suspended particles or in a structured packed form.
Patent AU-2021358110-A1 (AU)
Title: Engineered ipsc and armed immune effector cells
Inventor: LU DAN
IPC: C07K14/725
Filed: 2021-10-08
Abstract: Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The iPSC-derived cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the use thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
Patent AU-2021386149-A1 (AU)
Title: Tricyclic carboxamide derivatives as prmt5 inhibitors
Inventor: AMEGADZIE ALBERT
IPC: C07D498/04
Filed: 2021-11-22
Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formule (I).
Patent AU-2021417519-A1 (AU)
Title: Focused ultrasound device and method for setting order of focused ultrasound treatment thereof
Inventor: SON KEON HO
IPC: A61N7/02
Filed: 2021-02-24
Abstract: Disclosed are a focused ultrasound device and a method for setting an order of focused ultrasound treatment thereof. When using an ultrasound treatment method using mechanical energy, the focused ultrasound device according to an embodiment determines a next focal point position in consideration of at least one previous focal point position of focused ultrasound and thus can minimize thermal increase of an affected area and maximally utilize the mechanical energy.
Patent AU-2021418092-A1 (AU)
Title: Water path integrated structure and refrigerator having same
Inventor: YANG JUN
IPC: F25C1/00
Filed: 2021-11-23
Abstract: A water path integrated structure, comprising a filter (100), a water valve (200) and a kettle (300), which are in sequential communication with each other. The water valve (200) is in selective communication with the kettle (300) by means of a kettle water intake assembly (400). The kettle water intake assembly (400) comprises a water intake sleeve (410) and a water intake plug (420) rotatably inserted into the water intake sleeve (410), the water intake plug (420) and the water intake sleeve (410) are internally provided with water intake flow channels which can be in communication with each other. The water intake plug (420) is provided with a water intake limiting protrusion (421). The water intake sleeve (410) comprises a water intake cylindrical body (411), a water intake socket (412) provided in the water intake cylindrical body (411), and a water intake limiting hole (413) provided in a circumferential direction of the water intake cylindrical body (411). The water intake sleeve (410) is further provided with a water intake guide groove (414), and the water intake guide groove (414) extends in an axial direction of the water intake sleeve (410) from the water intake socket (412) and is in communication with the end of the water intake limiting hole (413). In the circumferential direction of the water intake cylinder body (411), the water intake limiting hole (413) is larger than the water intake guide groove (414) in terms of size. By means of the water path integrated structure, no water pipe needs to be arranged between the kettle (300) and the water valve (200), and the problems of a water pipe being difficult to maintain and water leakage due to bending damage are solved.
Patent AU-2022200323-A1 (AU)
Title: Anti-cd40l antibodies and methods for treating cd40l-related diseases or disorders
Inventor: LINCECUM JOHN M
IPC: C07K16/18
Filed: 2022-01-19
Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and 
methods for treating patients having a CD40L-associated disease.  
23