Patent SG-11201807868V-A (SG)
Title: Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
Inventor: ALTEN LEONIE
IPC: C12N15/10
Filed: 2017-03-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M1111101110101011111 HO 11111 0111310111111101011111001111101111 III N International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/158103 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 14/435 (2006.01) C12N 15/09 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 35/12 (2015.01) C12N 15/10 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 35/66 (2015.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/EP2017/056260 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 16 March 2017 (16.03.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 1604492.7 16 March 2016 (16.03.2016) GB kind of regional protection available): ARIPO (BW, GH, 62/308,975 16 March 2016 (16.03.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [DE/DE]; Paul-Ehrlich-StraBe 15, 72076 Tiibingen (DE). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: ALTEN, Leonie; WeiBdornweg 14, App. 161, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 72076 Tubingen (DE). MAURER, Dominik; Fleinerweg SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, _ 7, 72116 Moessingen (DE). BUNK, Sebastian; Staeudach GW, KM, ML, MR, NE, SN, TD, TG). — 182, 72074 Tiibingen (DE). Published: _ (74) Agent: BOEHMERT & BOEHMERT; Jan B. KRAUSS, — with international search report (Art. 21(3)) = Pettenkoferstrasse 20 - 22, 80336 Munich (DE). — with sequence listing of description (Rule 5.2(a)) part = = = = = = = = = = 1-1 M (54) Title: TRANSFECTED T-CELLS AND T-CELL RECEPTORS FOR USE IN IMMUNOTHERAPY AGAINST CANCERS 0 1-1 (57) : The present description relates to T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting GC cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. In particular, the L i ) present description relates to TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as MAG-003 S have the amino acid sequence of KVLEHVVRV (SEQ ID NO:1). The present description further relates to peptides, proteins, nude- IL— is acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of can- 1-1 c:::: ) cer. The present description furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other to - N mor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate an - 0 ti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histo - compatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding mo - 5. lecules.