baber/WOPTO huggingface dataset:
Patent EP-3898667-A2 (EP)
Inventor: LAZAR GREGORY A
IPC: C07K16/40
Filed: 2019-12-19
Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.
Patent EP-3703007-A2 (EP)
Inventor: LOU BIN
IPC: G06T7/174
Filed: 2020-02-26
Abstract: Brain tumor or other tissue classification and/or segmentation is provided based on from multi-parametric MRI. MRI spectroscopy, such as in combination with structural and/or diffusion MRI measurements, are used to classify. A machine-learned model or classifier distinguishes between the types of tissue in response to input of the multi-parametric MRI. To deal with limited training data for tumors, a patch-based system may be used. To better assist physicians in interpreting results, a confidence map may be generated using the machine-learned classifier.
Patent EP-4084821-A2 (EP)
Inventor: KATRAGADDA MADAN
IPC: A61P35/00
Filed: 2020-12-30
Abstract: L'invention concerne des molécules multifonctionnelles qui comprennent i) un domaine de liaison à l'antigène qui se lie à CD33 ; et l'un ou les deux d'un dispositif de mise en prise de cellule immunitaire (choisi, par exemple, parmi un dispositif de mise en prise de lymphocyte T, un dispositif de mise en prise de cellule NK, un dispositif de mise en prise de cellule B, un dispositif de mise en prise de cellule dendritique ou un dispositif de mise en prise de cellule macrophage) ou d'une molécule de cytokine. L'invention concerne également des acides nucléiques codant pour ceux-ci, des procédés de production des molécules précitées et des méthodes de traitement d'un cancer utilisant lesdites molécules.
Patent EP-3959981-A2 (EP)
Title: Fungicidal combinations
Inventor: FABRI CARLOS EDUARDO
IPC: A01P3/00
Filed: 2017-10-30
Abstract: A combination comprising a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol biosynthesis inhibitor fungicide or a quinone outside inhibitor fungicide.
Patent EP-4039688-A2 (EP)
Inventor: QIAN YIMIN
IPC: C07D487/04
Filed: 2022-02-02
Abstract: The present disclosure relates to novel compounds that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.
Patent EP-4086249-A2 (EP)
Inventor: SPEERSCHNEIDER AIMEE CROMBIE
IPC: A61K31/445
Filed: 2016-08-30
Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
Patent EP-4064443-A2 (EP)
Title: Lithium ion battery using crosslinkable separator
Inventor: ZHANG XUN
IPC: H01M50/494
Filed: 2019-10-11
Abstract: A separator for an electricity storage device, comprising 5 to 40 weight% of a silane-modified polyolefin and 60 to 95 weight% of a polyolefin other than the silane-modified polyolefin, wherein the storage modulus change ratio (R<sub>ΔE'</sub>) is 1.5 to 20, as defined by the following formula (1): RΔE′=E′S/E′j where E'j is the storage modulus measured at 160°C to 220°C for the separator for an electricity storage device before crosslinking reaction of the silane-modified polyolefin, E'<sub>S</sub> is the storage modulus measured at 160°C to 220°C for the separator for an electricity storage device after crosslinking reaction of the silane-modified polyolefin, and the measuring conditions for the storage modulus E' (E'j or E'<sub>S</sub>) are specified by the following (i) to (iv):(i) the dynamic viscoelasticity measurement is carried out under the following conditions:• Measuring apparatus: RSA-G2 (TA Instruments)• Sample thickness: from 5 µm to 50 µm• Measuring temperature range: -50 to 225°C• Temperature-elevating rate: 10°C/min• Measuring frequency: 1 Hz• Transform mode: sine wave tension mode (linear tension)• Initial static tensile load: 0.5 N• Initial gap distance (at 25°C): 25 mm• Auto strain adjustment: Enabled (range: 0.05 to 25% amplitude, 0.02 to 5 N sine wave load);(ii) the static tensile load is the median value of the maximum stress and minimum stress for each periodic motion, and the sine wave load is the vibrational stress centered on the static tensile load;(iii) the sine wave tension mode is measurement of the vibrational stress while carrying out periodic motion at a fixed amplitude of 0.2%, wherein in sine wave tension mode, the vibrational stress is measured while varying the gap distance and static tensile load so that the difference between the static tensile load and the sine wave load is within 20%, and when the sine wave load is 0.02 N or lower, the vibrational stress is measured while amplifying the amplitude value so that the sine wave load is no greater than 5 N and the increase in the amplitude value is no greater than 25%; and(iv) the storage modulus E'is calculated from the relationship between the obtained sine wave load and amplitude value, and the following formulas: σ*=σ0⋅Expiωt+δ,ε*=ε0⋅Expiωt,σ*=E*⋅ε*E*=E′+iE" where σ <sup>∗</sup> : vibrational stress, ε <sup>∗</sup>: strain, i: imaginary number unit, ω: angular frequency, t: time, δ: phase difference between vibrational stress and strain, E <sup>∗</sup>: complex modulus, E': storage modulus, E": loss modulus,vibrational stress: sine wave load/initial cross-sectional areastatic tensile load: load at minimum point of vibrational stress for each period (minimum point of gap distance for each period), andsine wave load: difference between measured vibrational stress and static tensile load.
Patent EP-4173740-A2 (EP)
Title: Light recycling for additive manufacturing optimization
Inventor: DEMUTH JAMES A
IPC: G02B27/10
Filed: 2016-10-28
Abstract: A method and an apparatus pertaining to recycling and reuse of unwanted light in additive manufacturing can multiplex multiple beams of light including at least one or more beams of light from one or more light sources. The multiple beams of light may be reshaped and blended to provide a first beam of light. A spatial polarization pattern may be applied on the first beam of light to provide a second beam of light. Polarization states of the second beam of light may be split to reflect a third beam of light, which may be reshaped into a fourth beam of light. The fourth beam of light may be introduced as one of the multiple beams of light to result in a fifth beam of light.
Patent EP-4305766-A2 (EP)
Inventor: HINDY AHMED
IPC: H04B7/06
Filed: 2022-04-13
Abstract: Apparatuses, methods, and systems are disclosed for parameter feedback for reciprocity-based Type-II codebook. One method (800) includes receiving (805), from a RAN, a codebook configuration corresponding to a port-selection codebook and receiving (810) a set of CSI reference signals. The method (800) includes identifying (815) a set of ports based on the CSI reference signals and generating (820) a set of coefficient indicators corresponding to the identified set of ports, where the port-selection codebook comprises a first bitmap that identifies a subset of the coefficient indicators assigned a non-zero amplitude value. The method (800) includes generating (825) a CSI report based the set of CSI reference signals and transmitting (830) the CSI report to the RAN, where the first bitmap is selectively included in the CSI report based on a size of the subset of coefficient indicators.
Patent EP-4223523-A2 (EP)
Inventor: GÜMMER ANDREAS
IPC: B32B37/08
Filed: 2023-01-10
Abstract: Die Erfindung betrifft Verfahren zum Laminieren eines aus mehreren Substratschichten (12) bestehenden Stapels (14) zu einem Verbundkörper (15), bei dem der Stapel (14) aus mehreren Substratschichten (12) in einer Laminierposition in einer Laminiervorrichtung (11) positioniert wird, bei dem mit einem Niederhalter (24) und/oder Laminierblech (28, 36) der Stapel (14) in der Laminierposition fixiert wird, bei dem zumindest eine Heizeinrichtung (31) in eine Arbeitsposition (35) zum Stapel (14) übergeführt und der Stapel (14) mit der zumindest einen Heizeinrichtung (31) auf eine Laminiertemperatur aufgeheizt und die Substratschichten (12) zu dem Verbundkörper (15) laminiert wird, bei dem darauffolgend die zumindest eine Heizeinrichtung (31) aus der Arbeitsposition (35) herausgeführt und zumindest eine Kühleinrichtung (32) in eine Kühlposition (34) zum Kühlen des Verbundkörpers (15) übergeführt wird, wobei die zumindest eine Kühleinrichtung (32) auf eine Starttemperatur zum Kühlen des Verbundkörpers (15) aufgewärmt wird, die niedriger als die Laminiertemperatur der Substratschichten (12) des Stapels (14) und höher als eine Kühltemperatur der Kühleinrichtung (32) am Ende des Kühlzyklus ist, wobei die mit der Starttemperatur aufgewärmte zumindest eine Kühleinrichtung (32) in die Kühlposition (34) zur Anlage an dem Niederhalter (24) und/oder Laminierblech (28, 36) übergeführt wird, und wobei nach der Einnahme der Kühlposition (34) durch die zumindest eine Kühleinrichtung (32) ein Absenken der Starttemperatur auf die Kühltemperatur der Kühleinrichtung (32) angesteuert wird.
Patent EP-4254426-A2 (EP)
Inventor: PENG YU
IPC: G16H50/30
Filed: 2020-05-28
Abstract: A computer-implemented method and system for selecting one or more regions of interest (ROIs) in an image. The method comprises: identifying one or more objects of interest that have been segmented from the image; identifying predefined landmarks of the objects; determining reference morphometries pertaining to the objects by performing morphometrics on the objects by reference to the landmarks; selecting one or more ROls from the objects according to the reference morphometrics, comprises identifying the location of the ROIs relative to the reference morphometries; and outputting the selected one or more ROls.
Patent EP-4316501-A2 (EP)
Inventor: LI WEN-HWA
IPC: A61K36/185
Filed: 2019-07-24
Abstract: Provided are botanical or bacterial extracts and methods of treating skin and other tissues by applying certain botanical or bacterial extracts, such as from Acronychia acidula, Licaria vernicosa, Calendula officinalis, Trigonella foenum-graecum or Actimomyces bacteria, to the skin or other tissue.
Patent EP-0013834-A2 (EP)
Inventor: THOMPSON JOHN ARTHUR
IPC: B01D71/10
Filed: 1979-12-28
Abstract: A hydrophilic, water-containing regenerated cellulose membrane is sequentially permeated under differential pressure with solvents of decreasing polarity so as initially to displace water in the membrane with a first solvent, and the or each other solvent in the sequence displacing the previous solvent. Each solvent has bulk liquid-liquid miscibility with the adjacent soivent(s) in the sequence, and the final solvents of the sequence exhibits bulk liquid-liquid miscibility with a material ultimately desired to be selectively permeated through the membrane. The first solvent is a lower (C,-C 4 ) alcohol or acetone. The resulting membrane is particularly suitable for at least partially separating, by permeation, a solvent used in dewaxing a waxy hydrocarbon oil from a solution of the oil and solvent.
Patent EP-0032593-A2 (EP)
Inventor: STADELMAYR HANS GUNTHER
IPC: G08B13/19
Filed: 1980-12-29
Abstract: Eine Alarm-, Sicherungs- und Überwachungsanlage enthält in einem Raum zumindest drei Sensoren (27 bis 31), die auf unterschiedliche, aber bei jedem Alarmereignis unvermeidlich auftretende physikalische Erscheinungen ansprechen bzw. auf die gleiche physikalische Erscheinung unterschiedlich bzw. auf zwei oder mehr verschiedene Weisen reagieren. Die Sensoren (27 bis 31) erfassen die gleiche Überwachungszone (25) und sind nach dem Majoritätsprinzip zusammengeschaltet (M).
Patent EP-0038546-A2 (EP)
Inventor: HABER EDGAR
IPC: A61K51/10
Filed: 1981-04-16
Abstract: Protein molecules are covalently bonded to a chelating agent which in turn binds a radioactive molecule. Prior to binding, the radioactive molecule is reduced with dithionite ion and then mixed with protein at a pH of 7.0 to about 8.0.
Patent EP-0045469-A2 (EP)
Inventor: ADAM FRITZ GUNTER DR RER NAT D
IPC: G11C17/00
Filed: 1981-07-28
Abstract: Es wird eine nichtflüchtige, elektrisch programmierbare Speicherzelle mit einer potentialmäßig schwebenden Gate-Elektrode (Fg) eines Lese-IGFETS (Tr) beschrieben, welche Elektrode (Fg) kapazitiv an eine Schreibelektrode (1) und eine Löschelektrode (2), die in Form von planaren Zonen des ersten Leitungstyps in einem halbleitenden Substrat (3) des zweiten Leitungstyps angeordnet sind, über Flächenteile einer Isolierschicht in einer das Überspringen von heißen Ladungsträger erlaubenden Dicke angekoppelt ist. Neben der Schreibelektrode (1), deren Flächenteil an der Gate-Elektrode (Fg) größer ist als der Flächenteil an der Löschelektrode (2), ist im geringen Abstand davon ein Diffusionsbereich (4) kleinerer Flächenausdehnung als die der Schreibelektrode (1)vom gleichen Leitungstyp wie der des Substrats (3) angeordnet. Die Speicherzelle wird durch Aufladen der Gate-Elektrode (Fg) mittels heißer Minoritätsladungsträger des Substrats (3) über die weitere Zone (4) geschrieben und mittels heißer Ladungsträger aus der Löschelektrode (2) gelöscht.
Patent EP-0056093-A2 (EP)
Title: Process for producing a printed circuit board
Inventor: TAKAHASHI KATSUHIRO
IPC: H05K3/42
Filed: 1981-10-27
Abstract: Disclosed is an improvement of a process for producing a printed circuit board by the so-called photo-forming method, comprising (A) a step of providing an adhesive layer on one side or both sides of an insulating substrates, (B) a step of roughening, and imparting a hydrophilic property to, the surface of said adhesive layer by a physical or chemical method, (D) a step of forming on the substrate a light sensitive material layer containing a metal in a reducible oxidized state capable of forming catalytic nuclei for non-electrolytic plating, and a light sensitive reducing agent, (E) a step of reductively precipitating metal particles constituting catalytic nuclei by selectively exposing said light sensitive material layer, and (F) a step of forming a conductor circuit layer by non-electrolytic plating after removing non-exposed portions of said light sensitive material layer; wherein the improvement comprises providing between the step (B) and the step (D), a step (C) of depositing fine particles of a light sensitive metal oxide semiconductor at least on the inner wall surface of a through hole.
Patent EP-0035407-A2 (EP)
Inventor: MITANI TATEKI
IPC: G05D23/24
Filed: 1981-03-03
Abstract: The invention relates to a glow plug control system which comprises a controller (14) connected to a vehicle battery (10) to an ignition switch (10), an indicator lamp (26) and a relay (28) for applying heating current to the glow plugs (36). A constant current source (40) within the controller (14) applies a quiescent current to the glow plugs (36) and the voltage developed across the glow plugs (36) is sensed by a comparator 24 to determine the actual temperature of the glow plugs (36). The relay (28) is operated intermittently by the output circuit (22) of the controller (14) the time of conduction being proportional to the difference between the desired and the actual temperatures of the glow plugs (36).
Patent EP-0042279-A2 (EP)
Inventor: RASMUSSEN CHRIS ROYCE
IPC: C07D243/04
Filed: 1981-06-15
Abstract: N-(substituted phenyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl) or (4,5,6,7-tetrahydro-1-H-1,3-diazepin-2-yl) ureas and pharmaceutically-acceptable salts thereof are disclosed to be useful in relieving the symptoms associated with irritable bowel syndrome, and as anti-diarrheal agents and as antihypertensives.
Patent EP-0043727-A2 (EP)
Inventor: BARNETT ROGER
IPC: B24D9/00
Filed: 1981-07-06
Abstract: A shoe 1 for supporting a belt, e.g. a sanding belt has a belt supporting surface 2 non-linear in cross-section perpendicular to the direction of belt extension and shaped such that a belt may bend sharply around the surface 2 in its direction of extension whilst conforming to the surface 2 without stretching. A sanding wheel comprises a plurality of such shoes 1 arranged as spokes of the wheel, which may be unitary in construction, and having a sanding belt extending around the wheel.
Patent EP-0051930-A2 (EP)
Inventor: SGHIBARTZ CRISTIAN MARIUS
IPC: C09D5/16
Filed: 1981-10-19
Abstract: A marine paint capable of becoming smoother in relatively moving sea water and having no or a low content of organotin comprises a film-forming acrylic polymer and a metalliferous pigment which is sparingly soluble in seawater. The acrylic polymer comprises 20-100 per cent by weight of monomer units (A) selected from methyl acrylate and ethyl acrylate units, 0-45 per cent by weight of monomer units (B) of a triorganotin salt of an olefinically unsaturated carboxylic acid and 0-80 per cent by weight of monomer units (C) which are alkyl methacrylate units having 1-4 carbon atoms in the alkyl group or styrene units. Monomer units (A), (B) and (C) form at least 80 per cent by weight of the acrylic polymer; the balance of the polymer if any comprises units of at least one other olefinically unsaturated comonomer.
Patent EP-0055101-A2 (EP)
Inventor: KELLY JOHN WILLIAM
IPC: B21D39/06
Filed: 1981-12-18
Abstract: A hydraulic swaging mandrel (10) with a cyiindrical body (12) is inserted in the end portion of a steam generator tube (16) positioned in a bore in a tube sheet (18). To define the ends of an internal volume (24) between the mandrel body (12) and the tube (16), 0-ring seal members (26) and (28) carried by the mandrel body (12) fit within the tube (16). To reducefric- tional resistance by the seal members (26, 28) to insertion of the body (12) into the tube (16), the body (12) has conical ramp sections (34) and (36) tapering towards each other so that the seal members (26, 28) can lodge at the smaller diameter ends of these ramp sections (34, 36) while the body (12) is being inserted. One seal member (26) is driven to the smaller end of the section (34) by the frictional forces during insertion, and a spring (52) is provided on the body (12) to drive the other seal member (28) to the smaller end of the other section (36). When the mandrel body (12) is fully inserted, pressurised hydraulic fluid is forced into the annular space (24) between the seal members (26, 28) which are thereby driven back up the respective ramp sections (34,36) to fixed positions defining the ends of the volume (24) to be expanded by radially outward deformation of the tube (16) into sealing contact with the surface of the bore in the tube sheet (18).
Patent EP-0057913-A2 (EP)
Inventor: KLIPPERT HEINZ DR
IPC: C08F14/06
Filed: 1982-02-04
Abstract: A novel process for the preparation of homopolymers, copolymers or graft polymers of vinyl chloride in an aqueous suspension in the presence of small amounts of gaseous oxygen, a particular suspending agent combination and further conventional polymerisation assistants employs at least three water-soluble suspending agents which differ in their dynamic interfacial tension, measured by the Traube method, as follows:  suspending agent A = 1.0 to 6.0 mN/m,  suspending agent B = 6.1 to 16.0 mN/m and  suspending agent C = 16.1 to 29.0 mN/m. The polymers prepared in this way have particularly high bulk densities, good residual monomer-removal properties, favourable particle size distribution, good miscibility with plasticisers at elevated temperatures and good initial colour as well as good processing properties as thermoplastics. Polymers grafted onto elastomers can be converted at high extruder output into mouldings of good surface quality and high impact strength.
Patent EP-0064185-A2 (EP)
Inventor: AKAZAWA TOSHITADA C O HODOGAYA
IPC: C25B9/17
Filed: 1982-04-14
Abstract: Disclosed is an improved process for electrolytically producing alkaline chlorate, carried out at an increased temperature by using an apparatus of a column type. The apparatus has a lower electrolysis zone, an intermediate reaction zone and an upper hydrogen-separation zone. The reaction zone has a central hollow section and a circumferential hollow section surrounding the central section. A solution to be electrolyzed is forced to circulate through the three zones by hydrogen gas generated so that the solution is allowed to flow down through the circumferential hollow section in a piston-flow manner after the hydrogen gas is separated from the solution. While the solution is passing through the circumferential section, effective auto-oxidation of hypochlorous acid is attained thereby causing the current efficiency of the electrolysis to be improved.
Patent EP-0065674-A2 (EP)
Title: Plaster fillet for the realization of flat sub-plasters
Inventor: MAISCH WALTER SR
IPC: E04F21/04
Filed: 1982-05-05
Abstract: 1. Plaster profile strip, intended for the production of planar underplasters, with a profile edge formed as offtake edge and two expanded metal fields, which extend away therefrom while including an acute angle, as fastening limbs for mounting at a wall to be plastered, characterised by the use for the production of planar insulating plasters of great thickness as rail as thereby, that the expanded metal fields (14, 15) display large mesh size and extend on the sides remote from the profile edge (11) away directly from narrow strip bands (12, 13), which are arranged in V-shape and form the profile edge, in respective planes defined by them.
Patent EP-0057567-A2 (EP)
Inventor: HIRATA HIDETOSHI
IPC: H05B6/80
Filed: 1982-01-27
Abstract: Disclosed is a cooking apparatus having operating keys for selecting a cooking menu, a display device having a number of display cards each inscribed with a cooking menu, and a rotatable member having the display cards swingingly secured along its periphery. The display cards are successively turned to successively change the displayed menu according to the rotation of the rotatable member. The cooking apparatus further has drive means for rotating the rotatable member, control means for controlling the drive means to rotate to the position determined by the signal from the operating keys. The apparatus further comprises heating device for heating items to be cooked, and means for operating the heating device according to a sequence corresponding to the cooking menu displayed on the displaying device by the signal from the operating keys.
Patent EP-0089056-A2 (EP)
Inventor: OSWALD GUNTER
IPC: A23L33/22
Filed: 1983-03-15
Abstract: 1. A process for preparing a dietetic agent having a cholesterol-lowering activity from apple marc, characterized in that dried apple marc after drying is a) extracted with water or diluted aqueous alcohol or with aqueous alcohol containing an acid, b) digested with a physiologically acceptable inorganic or organic acid at a pH value of less than 3, c) neutralized and d) either ground with admixed ascorbic acid when wet, pelletized and dried with hot air below 100 degrees C or dried with hot air below 100 degrees C, ground when dry, mixed with ascorbic acid and agglomerated by renewed addition of water and/or diluted alcohol.