Patent SG-11201407660S-A (SG)
Title: Systems and methods for detection of particles in a beneficial agent
Inventor: MATAYOSHI EDMUND
IPC: G01N21/95
Filed: 2013-05-23
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177434 A3 (51) International Patent Classification: G01N15/02 (2006.01) G01N21/64 (2006.01) G01N15/06 (2006.01) G01N21/90 (2006.01) G01N 21/51 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/042481 23 May 2013 (23.05.2013) English (30) Priority Data: 61/651,211 13/841,143 24 May 2012 (24.05.2012) 15 March 2013 (15.03.2013) English US US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, IL 60064 (US). (72) Inventors: MATAYOSHI, Edmund; 4410 Squires Green, Richmond, IL 60071 (US). WANG, Jie; 12889 W. Sanctu­ ary Lane, Bluff, IL 60044 (US). (74) Agents: HULSEBERG, Daniel J. et al.; Baker Botts LLP, 30 Rockefeller Plaza, New York, NY 10112-4498 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date publication of of the international search report: 30 January 2014 (54) Title: SYSTEMS AND METHODS FOR DETECTION OF PARTICLES IN A BENEFICIAL AGENT 200 Lasefbeam ~ C |inder y lens 206 Pre—filled Syringe •t •t i> i> CCD Camera _^-202 CCD Camera Lens CCD Camera Prcessor —501 \irx r r ^ i 208 Cylinder lens Indicator -210 • FIG. 13 i-H o CJ o & (57) Abstract: Detection particles of in a liquid beneficial agent contained within container a (206) includes selectively illuminating at least a portion of the liquid beneficial agent, obtaining an image from the illuminated portion of the liquid beneficial agent, ana - lyzing image data representing the image, using data a processor (501), to obtain a particle concentration, measuring an image in­ tensity value of the image data using the data processor (501), and determining quality level of a the liquid beneficial agent using the data processor (501) based on the particle concentration and the measured image intensity value. The liquid beneficial agent can be biologies, small molecule pharmaceuticals, nutritional products, or combinations thereof. The container may be a syringe (206).