baber/WOPTO huggingface dataset:
Patent WO-2021066840-A1 (WO)
Title: Anti-cd25 antibody-maytansine conjugates and methods of use thereof
Inventor: RABUKA DAVID
IPC: A61K47/64
Filed: 2019-10-04
Abstract: The present disclosure provides anti-CD25 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
Patent WO-2020081767-A1 (WO)
Title: Diagnostic and therapeutic methods for sarcomatoid kidney cancer
Inventor: SCHIFF CHRISTINA
IPC: A61K39/00
Filed: 2019-10-17
Abstract: The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of cancer (e.g., kidney cancer (e.g., renal cell carcinoma (RCC)). The invention is based, at least in part, on the discovery that expression levels of one or more biomarkers described herein in a sample from an individual having cancer can be used in methods of predicting the therapeutic efficacy of treatment with a VEGF antagonist (e.g., an anti-VEGF antibody, (e.g., bevacizumab) or a VEGFR inhibitor (e.g., a multi-targeted tyrosine kinase inhibitor (e.g., sunitinib, axitinib, pazopanib, or cabozantinib))) and a PD-L1 axis binding antagonist (e.g., a PD-L1 binding antagonist (e.g., anti-PD-L1 antibody, e.g., atezolizumab (MPDL3280A)) or a PD-1 binding antagonist (e.g., anti-PD-1 antibody)), or with an angiogenesis inhibitor (e.g., a VEGF antagonist (e.g., a VEGFR inhibitor, (e.g., a multi-targeted tyrosine kinase inhibitor (e.g., sunitinib, axitinib, pazopanib, or cabozantinib)))).
Patent WO-2020086753-A1 (WO)
Title: Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields
Inventor: WARDAK MIRWAIS
IPC: A61N1/32
Filed: 2019-10-23
Abstract: In the context of a stem cell-based therapy in which differentiated cells are derived from pluripotent stem cells, this application discloses approaches for eliminating residual pluripotent stem cells that may remain in a batch of differentiated progeny cells. This advantageously prevents the formation of teratoma tumors when the differentiated cells are eventually used for the therapy. This can be accomplished by exposing the batch of differentiated progeny cells and the residual pluripotent stem cells to an alternating electric field for a period of time. The frequency and field strength of the alternating electric field are such that the pluripotent stem cells die off as a result of exposure to the alternating electric fields, while the differentiated cells remain substantially unharmed. This results in a purified batch of differentiated progeny cells that is rendered safe for use in the stem cell-based therapy.
Patent WO-2021086315-A1 (WO)
Inventor: STANCIL CHARLES
IPC: G06F21/50
Filed: 2019-10-29
Abstract: An example computing device includes a tracking device, an interface, a processor, and a controller. The interface including a power pin, a data pin, and a clock pin, where the interface is to couple the tracking device to the computing device via the power pin and the data pin, and the clock pin is disconnected from the tracking device. The controller is communicatively coupled to the processor and the interface, the controller is to control an operation of the tracking device via the data pin.
Patent WO-2020097249-A1 (WO)
Title: Headphone acoustic transformer
Inventor: TISCARENO VICTOR MANUEL
IPC: H04R1/28
Filed: 2019-11-06
Abstract: An acoustic transformer for use in a headphone to enhance an auditory experience of a listener, includes a disc or plate with acoustic apertures or aperture regions that is located in front of an acoustic driver in an ear cup of the headphone. In an example configuration, one side or area of the acoustic transformer includes multiple, smaller apertures and an opposite side or area of the acoustic transformer includes a lesser number of larger apertures, or a single larger aperture. When the headphone is over the listener's ear the acoustic transformer is juxtaposed between the acoustic driver and the listener, and in an example configuration the smaller apertures are located toward the front of the listener's ear, and the larger aperture is located toward the back of the listener's ear.
Patent WO-2020102222-A1 (WO)
Title: Automated teaching of pick and place workflow locations on an automated programming system
Inventor: WHITE WILLIAM H
IPC: G05B19/042
Filed: 2019-11-12
Abstract: The operator may first place a blank device in a first socket in a first site. The APS may self-teach the position and orientation of that first socket by removing and replacing the device in the socket one or more times, and by detecting the position of the device in the socket or by monitoring a change in position of the device as it is placed into the socket. The APS then picks the device from the first socket (or from the input tray) and moves it in succession through the rest of the sockets to establish position and orientation of each socket. After all sockets are taught, the APS loads all sockets with blank devices, and programming begins. Alternatively, the programming job begins as each site is taught and before the remaining sites are taught so that production output can begin "immediately."
Patent WO-2020102507-A1 (WO)
Inventor: ANDREWS RICHARD
IPC: C12N1/12
Filed: 2019-11-14
Abstract: The present disclosure provides recombinant  Staphylococcus  bacterium ( e.g. 
 S. epidermidis ) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant  Staphylococcus  bacterium comprising two inactivated alanine racemase genes (Δalr1 Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant  Staphylococcus  bacterium. In another aspect, the disclosure features a method of treating or preventing a rash in a subject, comprising administering to the subject a population of the recombinant  Staphylococcus  bacterium of any one of the aspects or embodiments described herein, in an effective amount to treat or prevent the rash in the subject.
Patent WO-2020112589-A1 (WO)
Inventor: COOK CAITLYN
IPC: G02F1/1334
Filed: 2019-11-25
Abstract: According to one aspect of an inventive concept, a pre-polymer matrix formulation for a polymer dispersed liquid crystal (PDLC) display includes a monofunctional monomer, a trifunctional oligomer, and a trifunctional monomer. According to another aspect of an inventive concept, a product includes a PDLC display formulation comprising a polymer matrix having a plurality of liquid crystal (LC) domains dispersed therein, wherein the polymer matrix comprises a polymerized product of a monofunctional monomer, a trifunctional oligomer, and a trifunctional monomer, and a pair of electrodes having the PDLC display formulation positioned therebetween. The PDLC display formulation is characterized as having a substantially constant optical transparency during application of a low power direct current (DC) electromagnetic field between the electrodes for a predefined duration of time.
Patent WO-2020113076-A1 (WO)
Inventor: COBB JOSHUA MONROE
IPC: C12M1/34
Filed: 2019-11-27
Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.
Patent WO-2020123451-A1 (WO)
Title: Amélioration de l'extraction de photons avec des nanoparticules sur des nanostructures semi-conductrices
Inventor: GREER HAROLD FRANK
IPC: H01L21/02
Filed: 2019-12-10
Abstract: Des nanoparticules déposées sur une structure semi-conductrice permettent de commander la rugosité de surface par gravure, l'indice de réfraction par sélection d'une fraction de remplissage de nanoparticules à l'air, et de commander la rugosité efficace en jouant le rôle de centres de diffusion pour les photons.
Patent WO-2020132431-A1 (WO)
Inventor: CHAN BRIAN
IPC: A63F9/24
Filed: 2019-12-20
Abstract: La présente invention concerne, selon des modes de réalisation, l'adaptation d'actifs pour un jeu vidéo sur la base d'une interaction avec des réseaux sociaux. Des instructions sont envoyées à un dispositif informatique associé à une plate-forme de réseau social pour créer un message de réseau social comprenant au moins un élément de contenu multimédia relatif à un jeu vidéo, ledit élément de contenu multimédia étant produit par un joueur du jeu vidéo. Des données sont reçues en provenance du dispositif informatique, indiquant une ou plusieurs indications d'interaction utilisateur avec le message de réseau social. Un score est déterminé pour le joueur sur la base, au moins en partie, des données reçues indiquant les une ou plusieurs indications de l'interaction utilisateur concernant le message de réseau social. Un ou plusieurs actifs du jeu vidéo sont adaptés au joueur sur la base, au moins en partie, du score déterminé pour le joueur.
Patent WO-2020146379-A1 (WO)
Title: Gas vesicle expression systems, gas vesicle constructs and related genetic circuits, vectors, mammalian cells, hosts, compositions, methods and systems
Inventor: FARHADI Arash
IPC: C07K14/195
Filed: 2020-01-07
Abstract: Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
Patent WO-2020167393-A1 (WO)
Title: Contact de grille sur processus actifs
Inventor: THAREJA GAURAV
IPC: H01L29/417
Filed: 2020-01-09
Abstract: Processus de fabrication de dispositif semi-conducteur consistant à former des grilles sur un substrat ayant une pluralité d'ouvertures, chaque grille ayant une couche conductrice d'un premier métal et d'une couche diélectrique de grille d'un premier matériau diélectrique, à remplir partiellement les ouvertures d'un deuxième matériau diélectrique, à former une première structure sur le substrat dans un système de traitement sans casser le vide, à déposer un troisième matériau diélectrique sur la première structure, et à former une surface planarisée des grilles et une surface du troisième matériau diélectrique qui est disposé sur la première structure. La formation de la première structure consiste à former des tranchées par élimination de secondes parties du deuxième matériau diélectrique dans chaque ouverture, à former des régions actives évidées dans les tranchées par remplissage partiel des tranchées avec un second métal, à former un revêtement sur chaque région active évidée, et à former une couche de protection métallique sur chaque revêtement.
Patent WO-2021118610-A1 (WO)
Inventor: TARGALI YOUSIF
IPC: H04W12/00
Filed: 2020-01-15
Abstract: Systems and methods for provisioning user privacy parameters necessary for network security in 5G telecommunication networks are provided, such as the subscriber permanent identifier (SUPI), the routing indicator, the protection scheme identifier, or the home network key. In order to protect the user privacy parameters, the techniques disclosed herein use private and public key encryption, as well as integrity protection offered by 5G telecommunications protocols. Such techniques use registration response messages, update location requests, or update notification request messages to provide end-to-end or end-to-middle security in the provisioning process. Unlike existing over- the- air (OTA) techniques, the techniques described herein provision user privacy parameters or other similar data in a secure and verifiable manner.
Patent WO-2020163715-A1 (WO)
Title: Méthodes, compositions et kits pour traiter une maladie inflammatoire ciblant il18r1
Inventor: BILSBOROUGH JANINE
IPC: C12Q1/68
Filed: 2020-02-07
Abstract: L'invention concerne des méthodes, des systèmes, des compositions et des kits utiles pour le diagnostic et/ou le traitement d'une maladie ou d'une pathologie chez un sujet. La présente invention concerne des méthodes et des systèmes permettant l'identification et la stratification de patients appropriés pour un traitement avec des modulateurs de IL18R1 tels que décrits dans la description.
Patent WO-2020222890-A1 (WO)
Inventor: VON GYNZ-REKOWSKI GUNTHER
IPC: E21B4/14
Filed: 2020-02-13
Abstract: A vibration assembly includes a valve above a rotor and stator. The rotor rotates within the stator as fluid flows therethrough. The valve includes a rotating valve segment, which rotates with the rotor, and a non-rotating valve segment each including at least one fluid passage. In an open position, the fluid passages of the valve segments are aligned and a fluid flows through the valve. In a restricted position, the fluid passages of the valve segments are partially or completely unaligned, thereby creating a pressure pulse that is transmitted through the drill string or coiled tubing above the valve. The valve may further include an inner sleeve and an outer sleeve surrounding the non-rotating valve segment. The inner and outer sleeves allow axial sliding but prevent rotation of the non-rotating valve segment. The assembly may further include a lower thrust bearing at a lower end of the rotor.
Patent WO-2020172590-A1 (WO)
Title: Synthesis of biomimetic cell wall structure
Inventor: WANG YONG
IPC: B01D71/06
Filed: 2020-02-21
Abstract: The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.
Patent WO-2020176616-A1 (WO)
Inventor: MOHANTY PRAVANSU S
IPC: B22F7/00
Filed: 2020-02-26
Abstract: Provided are methods and devices for forming high nitrogen steel. The processes include heating a steel precursor to a temperature that transforms the steel into an austenite of FCC wherein the heating is in a nitrogen containing atmosphere. After an optional nitrogen uptake time, the precursor is further heated to a temperature above the T γN  of the steel yet below the melting point of the steel thereby preserving a solid and creating a solid solution of nitrogen. The second temperature is optionally maintained for a nitride conversion time, optionally wherein the nitride conversion time is too short to result in sintering of the steel. The process further includes rapid quenching of the precursor powder to maintain the nitrogen solid solution and prevent nitride formation thereby forming a high nitrogen steel with little to no nitride content and including nitrogen in solid solution.
Patent WO-2020205684-A1 (WO)
Title: Automated signal compliance monitoring and alerting system
Inventor: JORDAN LAWRENCE B
IPC: G07C5/00
Filed: 2020-03-29
Abstract: A data acquisition and recording system (DARS) for mobile assets that includes a data recorder and an automated signal monitoring and alerting system. The data recorder includes a data encoder, an onboard data manager, a vehicle event detector, at least one local memory component, and a queueing repository. DARS processes data from at least one input sensor and stores a compressed record of the data at least once per second in the local memory module. DARS is designed to run in near real-time mode, storing a full record comprising five minutes of data to a remote memory module every five minutes, and in real-time mode, streaming data to the remote memory module by uploading a record of data at least once per second and up to once every tenth of a second. Remotely located users can view video, audio, and data acquired by DARS through a web browser, which provides for quicker emergency response, validate the effectiveness of repairs and rerouting, and monitor crew performance and safety, and receive signal compliance and signal violations in real-time.
Patent WO-2020222986-A1 (WO)
Inventor: SAZAN DAVID
IPC: G06Q30/06
Filed: 2020-04-08
Abstract: A method of analyzing images by a computing device to generate an e-commerce interface, comprising receiving, from a computing device associated with a first human user, a list of items associated with the first human user; receiving, from a computing device associated with a merchant, purchasing information for each item of the list of items; receiving, from a second human user, one or more images depicting the first human user using one or more items from the list of items; automatically analyzing the one or more images to identify the one or more items; and generating a user interface comprising at least one of the one or more images, links to a computing system of the merchant from which the second human user may obtain the one or more items identified.
Patent WO-2020220013-A1 (WO)
Inventor: GREEN ALEXANDER
IPC: C12N15/66
Filed: 2020-04-27
Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of molecular analytes such as antibodies, proteins, and small molecules using protein-driven nucleic acid assemblies to activate CRISPR-Cas nucleases. Also provided herein are uses of the sensitive analyte detection methods in an analyte detection platform and in convenient low-cost diagnostic assays such as lateral flow devices for point-of-care use.
Patent WO-2021158249-A1 (WO)
Title: Power management for multi-plane read operations
Inventor: LIEN YU-CHUNG
IPC: G11C8/08
Filed: 2020-05-28
Abstract: Apparatuses and techniques are described for managing power consumption in a memory device. When a multi -plane read command is received, a control circuit determines whether the blocks identified by the read command are fully or partially programmed. If they are fully programmed, the read command is executed while applying a common read pass voltage to the unprogrammed word lines of the respective blocks. If the blocks are not all fully programmed, the control circuit determines a last-programmed word line. If the last-programmed word lines are not equal in each block, the read command is executed while applying a base read pass voltage to the unprogrammed word lines of one or more higher-programmed blocks and a lower read pass voltage to the unprogrammed word lines of one or more lower-programmed blocks.
Patent WO-2020247422-A1 (WO)
Inventor: MARANHAO JASON
IPC: A61L2/03
Filed: 2020-06-03
Abstract: A method and apparatus to autonomously analyze the surface area and alloy composition ratios of a metallic implant, such as an orthopedic implant, so that an optimal voltage for biofilm disruption can be selected and make treatment easier based at least in part upon the autonomous detection of a hydrogen evolution reaction threshold.
Patent WO-2020252010-A1 (WO)
Inventor: VETHAKE THILO
IPC: H01S5/024
Filed: 2020-06-10
Abstract: A laser diode heat sink including: a main body portion formed of metal; an electrically insulating layer on a principal surface of the main body portion, in which an interface between the main body portion and the electrically insulating layer includes multiple interlocking structures; and a metal mounting layer for mounting a laser diode on the electrically insulating layer.
Patent WO-2021034381-A1 (WO)
Title: Multi-layer document structural info extraction framework
Inventor: LI ZILIU
IPC: G06F40/279
Filed: 2020-06-11
Abstract: Configurations herein comprise a multi-layer framework to extract document structural data. The framework extracts structural data from raw, unstructured, electronic documents, for example,.pdf documents. Structural data refers to the semantic elements, for example, paragraphs, lists, tables, titles etc. that may be visible in the displayed document but not described in electronic data.
Patent WO-2020252153-A1 (WO)
Title: Systems, methods, and apparatus for real-time dictation and transcription with multiple remote endpoints
Inventor: MONDRAGON DAVID
IPC: G10L15/00
Filed: 2020-06-11
Abstract: A method to allow for real-time dictation and transcription with multiple remote endpoints is provided. The method comprises evoking a primary application and a client device APP (or APP) to work with a remote hosted application to process audio for the primary application. The APP connects to the hosted application, and the hosted application receives and processes the audio. The hosted application returns the text to the client device, which text populates the primary application. The APP and/or the hosted application also transmits the text to a remote endpoint, such as, for example, a desktop computer or a laptop computer where the user can interact with the primary application and the text returned by the hosted application.
Patent WO-2020257107-A1 (WO)
Title: Sensibilisation à la circulation cellulaire à faible latence et à largeur de bande élevée
Inventor: ZHU XIPENG
IPC: H04L29/08
Filed: 2020-06-15
Abstract: L'invention concerne des techniques de communication sans fil. Selon un aspect, un nœud de réseau configure un profil de qualité de service (QoS) comprenant un ou plusieurs paramètres de QoS de niveau de fichier, le profil de QoS s'appliquant à un ou plusieurs fichiers associés à un flux de service associé à un équipement utilisateur (UE), chaque fichier du ou des fichiers comprenant une ou plusieurs unités de données de protocole (PDU) et un en-tête de chaque PDU de la ou des PDU du fichier comprenant un identifiant de fichier et un type de fichier du fichier et met en application le profil de QoS sur le ou les fichiers.
Patent WO-2020257627-A1 (WO)
Inventor: CHUNG TZE-CHIANG
IPC: C08F212/08
Filed: 2020-06-19
Abstract: A process for preparing long-chain branched isotactic polypropylene (LCB-PP) is provided. The process includes copolymerizing propylene with an asymmetric diene of formula I using a heterogeneous iso-specific MgCl 2 -supported Ziegler-Natta catalyst. The copolymerization results in an isotactic polypropylene-styrene (PP-St) copolymer of formula II. The process includes pelletizing the PP-co-BSt copolymer in an extruder to produce the LCB-PP. n is an integer from 1 to 4, x is an integer between 500 and 10,000, and y is an integer between 1 and 10.
Patent WO-2021011252-A1 (WO)
Inventor: CHEN LIANG
IPC: B01J8/18
Filed: 2020-07-08
Abstract: Apparatus and processes herein provide for converting hydrocarbon feeds to light olefins and other hydrocarbons. The processes and apparatus include, in some embodiments, feeding a hydrocarbon, a first catalyst and a second catalyst to a reactor, wherein the first catalyst has a smaller average particle size and is less dense than the second catalyst. A first portion of the second catalyst may be recovered as a bottoms product from the reactor, and a cracked hydrocarbon effluent, a second portion of the second catalyst, and the first catalyst may be recovered as an overhead product from the reactor. The second portion of the second catalyst may be separated from the overhead product, providing a first stream comprising the first catalyst and the hydrocarbon effluent and a second stream comprising the separated second catalyst, allowing return of the separated second catalyst in the second stream to the reactor.
Patent WO-2021022028-A1 (WO)
Inventor: KHAN ZESHAN ALI
IPC: A61B8/10
Filed: 2020-07-30
Abstract: A modular, headset for performing ophthalmic tests on a patient comprises a removable optical module that can be replaced based on ophthalmic testing need. A miniaturized fundus camera is provided and can be movably mounted within the headset, including to the optical module. The fundus camera position can be automatically adjusted to align the camera with a headset wearer's eye. Software controls image capture and captured images are combined assembled and combined to provide a wide field retinal image. The optical module can have replaceable sub-components allowing configuration for different ophthalmic tests, such as visual field testing and optical coherence tomography.