Patent SG-11201909153U-A (SG)
Title: Peptides and combination thereof for use in the immunotherapy against cancers
Inventor: DI MARCO MORENO
IPC: C07K14/47
Filed: 2018-04-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPO I PCT onion °nolo OH 1101 DID mil Imo oimIE (10) International Publication Number WO 2018/189148 Al (51) International Patent Classification: A61K 39/00 (2006.01) GO1N 33/50 (2006.01) C07K 14/47 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2018/059109 (22) International Filing Date: 10 April 2018 (10.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10 2017 107 697.2 10 April 2017 (10.04.2017) DE 62/483,702 10 April 2017 (10.04.2017) US (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-Strasse 15, 72076 Tuebingen (DE). (72) Inventors: DI MARCO, Moreno; Memminger- strasse 18/1, 72072 Tiibingen (DE). HAEN, Se- bastian; Brombergstrasse 15, 72070 Tiibingen (DE). KOWALEWSKI, Daniel; Denzenbergstrasse 29, 72074 Tiibingen (DE). DUELER, Markus; Sandgrabenstrasse 20, 72119 Ammerbuch (DE). NELDE, Annika; Vik- tor-Renner-StraBe 27, 72074 Tiibingen (DE). RAM- MENSEE, Hans-Georg; Sommerhalde 3, 72070 Un- terjesingen (DE). STEVANOVIC, Stefan; Auf der Burg 3, 72074 Tilbingen (DE). TRAUTWEIN, Nico; Pelargusstrasse 2, 70180 Stuttgart (DE). WALZ, Juliane Sarah; Gartenstrasse 71, 72076 Tiibingen (DE). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (74) Agent: KRAUSS, Jan, B.; Boehmert & Boehmert, Pet- tenkoferstrasse 20 - 22, 80336 Munich (DE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: PEPTIDES AND COMBINATION THEREOF FOR USE IN THE IMMUNOTHERAPY AGAINST CANCERS (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules. 1-1 00 71. 1-1 00 1-1 00 1-1 O C