Patent SG-11201804413X-A (SG)
Title: Recombinant serine proteases
Inventor: VERHOEF DANIËL
IPC: C12N9/74
Filed: 2016-11-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIIIII Hit II EH DID IIIII DEEM II III 1111111111 DID 11111111D It RID IIII (10) International Publication Number WO 2017/091074 Al WIPO I PCT (43) International Publication Date 1 June 2017 (01.06.2017) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (51) International Patent Classification: C12N 9/64 (2006.01) C12N 9/72 (2006.01) C12N 9/74 (2006.01) (21) International Application Number: PCT/NL2016/050833 (22) International Filing Date: 25 November 2016 (25.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15196291.7 25 November 2015 (25.11.2015) EP (71) Applicant: ACADEMISCH ZIEKENHUIS LEIDEN [NL/NL]; Albinusdreef 2, 2333 ZA Leiden (NL). (72) Inventors: VERHOEF, Daniel; c/o Einthoven Laboratory of Experimental, Vascular Medicine, Department of Trom- bosis and Hemostasis, LUMC, Albinusdreef 2, 2333 ZA Leiden (NL). REITSMA, Pieter H.; c/o Einthoven Labor- atory of Experimental, Vascular Medicine, Department of Trombosis and Hemostasis, LUMC, Albinusdreef 2, 2333 ZA Leiden (NL). BOS, Mettine H.A.; c/o Einthoven Laboratory of Experimental, Vascular Medicine, Depart- ment of Trombosis and Hemostasis, LUMC, Albinusdreef 2, 2333 ZA Leiden (NL). (74) Agent: JANSEN, C.M.; V.O., Carnegieplein 5, 2517 KJ Den Haag (NL). W O 20 17 /09 107 4 Al (54) Title: RECOMBINANT SERINE PROTEASES (57) : The present invention relates to recombinant proteins comprising serine protease polypeptides that have serine pro - tease activity in the presence of a serine protease inhibitor and that are able to completely or partially reverse a serine protease inhib - itor effect, for example in a subject treated with a serine protease inhibitor. More specifically, described herein are recombinant pro - teins and methods for completely or partially reversing an anti-coagulant effect of a coagulation inhibitor.