Patent SG-11201806110Q-A (SG)
Title: Treatment of cancer with combinations of immunoregulatory agents
Inventor: WILLINGHAM STEPHEN
IPC: C07K16/46
Filed: 2017-01-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/127707 Al 27 July 2017 (27.07.2017) WIPO I PCT 1111111111111101110101011111010111110111011101011101110111111111111111111110111111 International Patent Classification: C07K 16/46 (2006.01) C07K 16/28 (2006.01) International Application Number: PCT/US2017/014375 International Filing Date: 20 January 2017 (20.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/281,571 21 January 2016 (21.01.2016) US 62/301,981 1 March 2016 (01.03.2016) US (71) Applicant: THE BOARD OF TRUSTEES OF THE LE- LAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel, Building 170, 3rd Floor, Main Quad, P.O. Box 20386, Stanford, California 94305- 2038 (US). (72) Inventors: WILLINGHAM, Stephen; 1317 Victoria Ter- race, Sunnyvale, California 94087 (US). HO, Doris Po Yi; 139 MacDonald Avenue, Daly City, California 94014 (US). MCKENNA, Kelly Marie; 4192 Maybell Way, Palo Alto, California 94306 (US). WEISSMAN, Irving L.; 747 Santa Ynez Street, Stanford, California 94305 (US). VOLKMER, Jens-Peter; 12 Coleman Place, Apt. 2, Menlo Park, California 94025 (US). CHAO, Mark P.; 2001 Showers Drive, Mountain View, California 94040 (US). MAJETI, Ravindra; 861 Newell Place, Palo Alto, California 94303 (US). MCCRACKEN, Melissa N.; 910 Rich Avenue, Apt. 7, Mountain View, California 94040 (US). (74) Agent: SHERWOOD, Pamela J.; 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 171277 / 07 Al (54) Title: TREATMENT OF CANCER WITH COMBINATIONS OF IMMUNOREGULATORY AGENTS (57) : Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen com- prising contacting the targeted cells with a combination of immunoregulatory agents. The level of depletion of the targeted cell is en- hanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.