Patent SG-11201408347U-A (SG)
Title: Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides
Inventor: SUN YING
IPC: A61K47/48
Filed: 2013-06-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188740 A1 (51) International Patent Classification: A61K 47/48 (2006.01) C07K16/30 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/045834 14 June 2013 (14.06.2013) English English (30) Priority Data: 61/659,937 61/766,564 61/806,338 14 June 2012 (14.06.2012) US 19 February 2013 (19.02.2013) US 28 March 2013 (28.03.2013) US (71) Applicant: AMBRX, INC. [US/US]; 10975 North Torrey Pines Road, Suite 100, La Jolla, CA 92037 (US). (72) Inventors: SUN, Ying; 14972 Avenida Venusto #65, San Diego, CA 92128 (US). ZOU, Ning; 9829 Fieldthorn Street, San Diego, CA 92127 (US). HEWET, Amha; 1170 La Vida Court, Chula Vista, CA 91915 (US). PINK- STAFF, Jason, K.; 2095 Wandering Road, Encinitas, CA 92024 (US). SRINAGESH, Shailaja; 3877 Pell Place, Unit 104, San Diego, CA 92130 (US). BARNETT, Richard, S.; 306 Belmont Court, San Marcos, CA 92069 (US). TIAN, Feng; 8374 Orange Haven Place, San Diego, CA 92129 (US). PUTNAM, Anna-Maria, A. Hays; 11522 Cesped Drive, San Diego, CA 92124 (US). GYM- NOPOULOS, Marco; 3620 3rd Avenue, San Diego, CA 92103 (US). KNUDSEN, Nick; 1916 Rohn Road, Escon- dido, CA 92025 (US). BECK, Andrew; 4732 Kansas Street, Apt. 2, San Diego, CA 92116 (US). (74) Agent: WALLEN, III, John W.; 10975 North Torrey Pines Road, Suite 100, La Jolla, California 92037 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) © •t l> 00 00 i-H o CJ (54) Title: ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES (57) Abstract: This invention relates anti-prostate-specific membrane antigen antibodies to (aPSMA) and aPSMA antibody • ar receptor ligand (NRL) conjugates comprising at least one non-naturally-encoded amino acid. nucle -