baber/WOPTO huggingface dataset:
Patent EC-SP077185-A (EC)
Title: Derivados de piridina
Inventor: RAWSON DAVID JAMES
IPC: C07D213/81
Filed: 2007-01-19
Abstract: La presente invención se refiere a compuestos de la fórmula: (consta gráfico) y sales y solvatos farmacéuticamente aceptables de los mismos, a procedimientos para la preparación de , intermedios usados en la preparación de, y composiciones que contienen tales compuestos y los usos de tales compuestos para el tratamiento de dolor.
Patent EC-SP077306-A (EC)
Title: Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparación y su uso como antiinflamatorios
Inventor: SKUBALLA WERNER
IPC: C07F5/02
Filed: 2007-03-08
Abstract: La presente invención se refiere a derivados de alquiliden-tetrahidronaftaleno de la fórmula general I, procedimiento para su preparación y su uso como antiin-flamatorios.
Patent EC-SP088817-A (EC)
Title: Métodos para usar el receptor gpr119 en la identificación de compuestos útiles para aumentar la masa ósea en un individuo
Inventor: CHU ZHI-LIANG
IPC: C12Q1/68
Filed: 2008-10-09
Abstract: La presente invención está relacionada con métodos para usar el receptor GPR119 con el fin de identificar compuestos útiles para aumentar la masa ósea en un individuo. Los agonistas del receptor GPR119 son útiles como agentes terapéuticos para tratar o prevenir una afección caracterizada por masa ósea baja, como la osteoporosis, y para aumentar la masa ósea en un individuo. Los agonistas del receptor GPR119 promueven la formación de hueso en un individuo.
Patent EC-SP951557-A (EC)
Title: Analogos composiciones y procedimientos de uso de peptidos insulinotropicos similares al glucagon
Inventor: DIMARCHI RICHARD DENNIS
Filed: 1995-10-17
Abstract: El invento se refiere a análogos y derivados de péptidos insulinotrópicos similares al glucagón (GLP-(7-37). Los análogos incluyen sustituciones de aminoácidos, modificaciones del terminal amino y carboxilo y acilaciones de C6-C10. Los compuestos reivindicados estimulan la secreción o biosintesis de insulina en células beta con baja acción y son por lo tanto útiles en el tratamiento de los diabéticos tipo II.
Patent EC-SP951590-A (EC)
Title: Nuevas sulfonamidas case ran 4019/131
Inventor: NEIDHART WERNER
IPC: A61K31/505
Filed: 1995-11-22
Abstract: Compuestos de fórmula I.en donde R1 es heterociclilo;R2 es hidrógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, alcoxilo inferior-alquilo inferior, alquilsulfonilo inferior-alcoxilo inferior, fenilo alquilo inferior-fenilo, alcoxilo inferior-fenilo, alquileno inferior-dioxifenilo, fenilo alquilo inferior, alquilo inferior-fenilo-alquilo inferior, alcoxilo inferior-fenilo-alquilo inferior, alquileno inferior- dioxifenilo-alquilo inferior, heterociclilo o heterociclilo-alquilo inferior; R3 es alquilo inferior, alcoxilo inferior, formilo, haloalquilo inferior, hidroxilo-alquilo inferior, amino-alquilo inferior o un radical -CH2 O-A-alquilo inferior,-(CH2 )m -O-(CRa Rb )n OH, -(CH2 )m -O-(CRa Rb )n OR9 , -(CH2 )m -O-(CRa Rb )n NH2 ó -(CH2 )m -O-(CRa Rb )n - B-R9 ; R4 - R8 son hidrógeno, alcoxilo inferior o halógeno; R9 significa heterociclilo; fenilo o fenilo substituido con alquilo inferior, alcoxilo inferior y/o halógeno o alquilo inferior;Ra y Rb significan hidrógenoo alquilo inferior; A significa un grupo 1,2-dihidroxi-etileno cetalizado; B significa -OC(O)O-, -O(C(O)NH-, -NH(C(O)NH- ó -NHC(O)O-; n es 2, 3 o 4; y m es 0 ó 1".
Patent EC-SP982629-A (EC)
Title: Proteinas de fusion, proteina que proporciona epitopos auxiliares de t un antigeno de virus de papiloma humano
Inventor: BRUCK CLAUDINE
IPC: C07K14/025
Filed: 1998-08-17
Abstract: La presente invención proporciona proteínas de fusión del virus de papiloma humano (HPV), lígados a un acompañante de fusión inmunológico que proporciona etiopos auxiliares de T al antígeno de HPV. Se prueba que las formulaciones de las vacunas son útiles en el tratamiento o profilaxis de lesiones inducidas por HPV.
Patent FR-1603486-A (FR)
Title: Acrylic amide copolymer pressure sensitive - adhesive compositions
IPC: C09J7/38
Filed: 1968-12-02
Granted: 1971-04-19
Abstract: A pressure-sensitive adhesive comprising a copolymer of (a) 0.5-20 wt.% of N-(1,1-dimethyl-3-oxobutyl) substd. unsatd. carboxylic amide and (b) 99.5-80 wt.% of alpha-olefinic monomer. Preferably (a) is above substd. (meth)acrylamide and is present 1-10 wt.% of copolymer. The copolymer above may include 1-20C pref. 4-12C alkyl ester of acrylic acid in amts. >35 wt.% of copolymer or vinyl ester esp. vinyl acetate in amts. 10-60 wt.% of the total wt. of copolymer. The adhesive has high cohesive strength and improved strength retention.
Patent GB-1047359-A (GB)
IPC: F16K17/04
Abstract: 1,047,359. Valves. H. & H. BISHOP Ltd. Oct. 14, 1965, No. 43546/65. Heading F2V. A relief valve for a pit prop has a resilient valve member 34 housed in a recess in a bobbin 13. A support 39 prevents extrusion of the valve member into the seat opening 9. In closed position the bobbin engages over a spigot 8 on the seat and the valve member 34 is deformed into sealing engagement with a conical surface on this spigot. A surface 40 of the support and the end surface of the spigot which it engages are preferably etched so that sealing does not occur at these surfaces. The support has a projecting pin 37 with a head 38 which is inserted into the valve member 34 to retain the support. A spring retaining plate 20 engages notches in an adjustable sleeve 16 for varying the tension. The valve may also be opened by a lift rod connected to a stirrup 32. By pushing down the stirrup to engage notches 18 in screwed sleeve 16, the spring loading may be adjusted.
Patent GB-1050938-A (GB)
IPC: F16D13/68
Abstract: 1,050,938. Resilient couplings. W. V. THELANDER. Jan. 26, 1965 [Feb. 17, 1964], No. 3399/65. Heading F2U. A clutch plate 16 is circumferentially yieldably connected to a hub 7 by a number of torsion bars 11 having one end secured to the hub and the other end fast with a lever 13 (or 54) pivoted to the plate 16. In Fig. 1 the torsion bar 11 and lever 13 are formed integrally by a bent wire having one end 10 secured in a hole 9 of the hub 7 and the other end 14 passing through a hole 15<SP>1</SP> in the plate 16. A flange 8 welded to the hub 7 carries rivets 17 with which pass through slots 20 in the plate 16 which limits the circumferential yielding of the clutch plate. The plate 16 is frictionally held between a plate 23 and the flange 8 by spring washers 26 to provide friction damping. Alternate holes 15<SP>1</SP> may be elongated in the overrun and/or drive direction to provide a progressive spring characteristic. In Fig. 3 (not shown) the torsion bar 11a and levers 12a are formed as separate elements which are secured together and the inner circumference of the plate is held against a shoulder 43 of the hub by a spring washer 44. A nylon washer 46 may be interposed between the shoulder and plate to prevent noise. In Fig. 4 (not shown) the torsion bar 11b is arranged radially and has integral axially directed levers 47, 54 the former of which engages a groove 48 in the hub 7b whilst the latter 54 passes through holes 55 in the clutch disc 16b. The torsion bar passes through holes 49 in a plate 50 welded to the hub 7b to prevent lateral movement of the torsion bar. Rivets 56 between the plate 50 and a plate 57 pass through slots 20b in the plate 16 to limit the circumferential yielding of the plate. A spring washer 59 holds the plate 16b against a disc 58 of friction material to provide friction damping. In Fig. 5 (not shown) a radially outward extension 60 of the lever 54 passes through holes 61 in axially directed lugs 62 on the disc 16c so that the lever 54 provides additional torsion bar action.
Patent GB-1051373-A (GB)
IPC: G04R40/06
Abstract: 1,051,373. Synchronizing remotely positioned timing devices. Mc DONNELL AIRCRAFT CORPORATION. Sept.14, 1964, No.37528/64. Heading G3T. In a system for synchronizing a number of remotely positioned timing devices, for use, e.g. in satellites, in aircraft collision avoidance systems, or for navigation, the timing devices are of the kind such as those using a crystal oscillator or the like and capable of keeping time in very precise small increments. The system comprises means for assigning a different distinct group of increments to each timing device for synchronizing purposes, means for comparing the time of occurence of the assigned group of increments of each timing device with the time of occurence of the same increment group at another timing device to see if the compared groups occur simultaneously, and means for shifting the time of occurence of one of said compared groups at one of the timing devices relative to the time of occurence of the same corresponding increment groups at the other timing device in a direction to make similar later occurences of the same corresponding increment groups take place simultaneously at both of the timing devices. In one system for use between aircraft and a ground station and using a return signal, the aircraft carries a count-up counter 28, Fig. 1 (not shown) and the ground station carries both a count-up counter 28 and a count-down counter 30. When the countdown counter reaches the same count as that which was in its count-up counter on receipt of a signal, it transmits the return signal. This will be received displaced from the synchronization time by 2#T, where #T is the actual phase error. The propagation time between the aircraft and ground is automatically cancelled Figs.2 to 4, (not shown). Alternatively, count-up counters only may be used, that in the ground station being allowed to count up to a predetermined number of increments before a return signal is sent. Circuit means utilizing known devices, for performing the synchronization in the respective cases where both count-up and count-down counters are used or where count-up counters only are used, are disclosed, Figs. 5 and 9 (not shown). Particular groups of increments or "message slots" may be alloted to particular aircraft. There may e.g. be three thousand message slots in a three second period, so that each aircraft, up to a total number of three thousand, is synchronized once every three seconds.
Patent GB-1052568-A (GB)
IPC: B65B11/04
Abstract: 1,052,568. Packing columns of articles. RESTELLO A.B. Oct. 18, 1965 [Nov. 7, 1964; June 17, 1965; July 9, 1965], No. 44032/65. Heading B8C. A package 1, Fig. 3 (not shown), consisting of a stack of coins, or the like, is wrapped in a film 2 of heat shrinkable material. The film is wrapped so that it overlaps in a narrow helically shaped zone. When the film is heated, it shrinks and holds the coins &c. together. The portions of the film which protrude over the ends of the body 1 shrink and close the ends of the body. To facilitate opening of the package, a non-shrinkable strip 3a may be provided under the film 2, or the terminal end of the strip may be heated more than the rest of the film to form a tab 3, Fig. 2 (not shown). If a coloured plastics film is used, the overheated portion turns a darker shade. The package may be heated in two separate operations for this purpose. If the objects are wrapped in a trapezoidal film 2b, Fig. 4 (not shown), a tip 3b of the film serves as a tongue. The package is formed by apparatus comprising a supply roll 18, Fig. 5 (not shown), of heat-shrinkable film which is wrapped around the stack by three rollers 10, 11, 12. The coins are fed down a groove 4, Fig. 6 (not shown), and are stacked in a tube 5 on a plate 6. Two felt-covered rollers 10, 11 are pivoted about an axis A and press resiliently against the tube 5. A third feltcovered roller 12 is pivoted about an axis B and also resiliently presses against the tube 5. The rollers 10, 11, 12 are driven by geared wheels 16, 17. When the tube 5 is full of coins, it is retracted to a position 5<SP>1</SP> and the rollers 10, 11, 12 contact and hold the stack of coins. The heatshrinkable film is then fed by air nozzles 20, 21 and a guide 19 between the stack and the rollers. The guide 19 moves along the axis of the stack as the film is fed, to form a helical wrapping. The film is cut by a heated wire 22 and heated by a wire 23. The package is then pushed out by any suitable means.
Patent GB-1084248-A (GB)
IPC: B61C15/04
Abstract: 1,084,248. Railway vehicle undercarriages. ENGLISH ELECTRIC CO. Ltd. Sept. 10, 1964 [Sept. 13, 1963], No. 36159/63. Heading B7L. A locomotive having two or more bogies, e.g. 10, 11, Fig. 1, with driven axles includes airoperated piston means, e.g. 16, for exerting a desired upward pulling force on the trailing end of at least that bogie, e.g. 10, which is, or will be, leading relative to the direction of travel of the locomotive whereby to obtain a desired distribution of loading of the locomotive axles 12 to 15. In the two bogie locomotive shown the main frame 20 has mounted thereon on air-operated piston means 16, 17, 18 and 19, the pistons of the means acting on the bogies. When the locomotive is moving to the left only the means 16 and 17 are operative to exert a pull on the trailing end of the bogie 10 and a downward push on the leading end of the trailing bogie 11. If the locomotive travels to the right then only the means 18 and 19 are operative. As shown, each associated pair of piston means is connected to an air reservoir 22 supplied from an air line 23 via an isolating cock 24, pressure control valve 25 and a solenoid operated valve 26. The valves are in a controller 30, associated one with each pair of piston means. The valve 26 either connects the reservoir to the air line or to atmosphere. The controller is automatically operative according to the load on the electric traction motors and is rendered inoperative when the locomotive is coasting or braking.
Patent GB-1095587-A (GB)
IPC: C30B15/14
Abstract: 1,095,587. Crystal-pulling. SIEMENS & HALSKE A.G. Sept. 26, 1966 [Sept. 24, 1965], No. 42809/66. Heading B1S A monocrystalline silicon rod is pulled from a melt 4 in a quartz-lined graphite crucible 1 which is heated by radiation inwards from a resistance heated graphite cylinder 5 and upwards from a resistance heated graphite disc 8, the heating power of the two heating means being separately adjustable to maintain the diameter of the rod constant. The heating power of the cylinder may be maintained constant while that of the disc is increased or decreased as required. The disc and cylinder may be slotted from either side alternatively (Fig. 3) or spirally. The disc may have an upper convex surface (Fig. 2). The distance between the disc and the base of the crucible may be equal a quarter of the crucible diameter. The distance between the disc and the cylinder may equal the maximum thickness of the disc. The melt and/or rod may be rotated. A rotary shaft 3 may pass axially through the disc.
Patent GB-1225892-A (GB)
IPC: C07C67/00
Filed: 1969-01-30
Abstract: 1,225,892. Process for isolating acetylenic alcohols. RHONE-POULENC S.A. 30 Jan., 1969 [31 Jan., 1968], No. 47057/70. Divided out of 1,225,891. Heading C2C. Separation process for dehydrolinalool (I) and N - methylpyrrolidone comprises distilling a mixture of these and water with the aid of a column, washing the vapours at the column head with water, condensing the vapours and separating the liquid organic layer rich in I.
Patent GB-1226353-A (GB)
IPC: H02H7/00
Filed: 1968-03-27
Abstract: 1,226,353. Transistor switching circuits. W. H. JOENS & CO. G.m.b.H. 27 March, 1968 [12 April, 1967], No. 14722/68. Heading H3T. [Also in Divisions G3 and H2] To protect against incorrect operation due to open-circuit conditions in a control system having a signal generator 10 which presents a variable resistance to an amplifier, a shorting circuit 18 provides a low-resistance path when an open circuit occurs. When the resistance of the signal generator 10 falls below a predetermined value, a transistor 24 is rendered conducting which causes a transistor 26 to cease conducting so that a relay 14 is de-energized, e.g. to switch off a heating system when the temperature sensed by the signal generator 10 reaches a predetermined value. A short circuit on the conductors 16 leading to the signal generator 10 produces the same result. If an open circuit occurs in the conductors 16, the resulting increased voltage across a Zener diode 42 causes the diode to conduct and apply a triggering pulse to a transistor 46 which short-circuits the conductors 16 and causes the de-energizing of the relay 14.
Patent GB-1226500-A (GB)
IPC: C01B3/38
Filed: 1969-10-13
Abstract: 1,226,500. Oxo process. RUHRCHEMIE A.G. 13 Oct., 1969 [19 Nov., 1968], No. 50117/69. Heading C2C. [Also in Division C5] In an oxo process a carbonaceous by-product and/or a waste product of the process is reacted with water vapour and CO 2  over a nickel catalyst at a temperature in the range 600‹ to 900‹ C. to produce a gas mixture containing H 2  and CO for oxo synthesis. By-products and waste products referred to include isoaldehydes and distillation residues obtained by working up hydroformylation products, e.g. higher alcohols, acetals, aldols and esters, specifically isobutyraldehyde and the residues from the hydroformylation of propylene and ethylene.
Patent GB-1228570-A (GB)
IPC: C07H15/252
Filed: 1969-07-14
Abstract: 1,228,570. Esters of daunorubicin aglycone. RHONE-POULENC S.A. 14 July, 1969 [15 July, 1968; 2 June, 1969], No. 35425/69. Heading C2A. Novel esters of the aglycone of daunorubicin having the Formula (I) wherein R is (1) a cyclohexyl group substituted by aminomethyl or at least one amino, C 1 -C 5  mono- or di-alkylamino or sulphomethylamino group, and optionally substituted by at least one hydroxy or C 1 -C 5  alkanoyloxy group; or (2) a phenylalkyl group wherein the alkyl radical is C 1 -C 4  and is substituted by a bis(2- chloroethyl)amino group; or (3) a piperidyl group; and salts thereof, are prepared by reacting daunorubicin aglycone with an acid of formula R-COOH or an ester-forming derivative thereof, or when R is a sulphomethylamino. substituted cyclohexyl group by reacting a corresponding amino - substituted cyclohexyl compound of Formula (I) with formaldehyde and sodium metabisulphite. The ester-forming derivative of the acid is preferably the anhydride of which any amino groups are protected, e.g. by tort.-butyloxy-carbonyl, benzyloxycarbonyl or p-methoxybenzyloxy-carbonyl groups, which are subsequently hydrolysed off with dilute acid. When the acid contains -OH groups, these are protected by conversion to 2- tetrahydropyranyloxy groups, and subsequently restored to -OH by acid hydrolysis. The daunorubicin aglycone starting material is prepared by acid hydrolysis of daunorubicin at 100 C. and purified chromatographically. Pharmaceutical compositions having antitumour activity, comprise the compounds of Formula (I) or their non-toxic salts together with a pharmaceutically acceptable carrier or coating or the dry sterile compound in an ampoule for reconstitution for injection.
Patent GB-1231906-A (GB)
IPC: H01L31/02
Filed: 1969-03-31
Abstract: 1,231,906. Photo-detector. COMPAGNIE GENERALE D'ELECTRICITE. March 31, 1969 [March 29, 1968], No.16845/69. Heading G1A. [Also in Division H1] In a radiation detecting arrangement comprising an inversely biased photo-sensitive diode adapted to operate on the avalanche effect when it receives the raditation to be detected, a reference diode having a thermal sensitivity similar to that of the detecting diode is thermally coupled to the detection diode and its output is applied to control the supply voltage to the detection diode to effect temperature compensation. The diode may be PN, PIN or P#PN and a number of materials are exemplified. The diodes may be assembled on a single wafer with the reference diode larger than the detection diode and the pair may form part of a matrix. The bias voltage may be a pulsed source or the circuit may employ a modulator 22, Fig.6. Control is effected by a regulator 16 in response to a comparison in transistors 19, 20 and differential amplifier 18 of the voltage across diode 7 at K with that supplied to diode 6 at L. An explanation of the maintenance of constant multiplication is given with reference to Figs.1 2, 5, and 7 (not shown) application of the invention to a laser telemeter system and to guiding and tracking space craft is referred to.
Patent GB-1233905-A (GB)
IPC: B65B1/34
Filed: 1967-11-08
Abstract: 1,233,905. Weighing apparatus. C. H. BANKS. Oct. 29, 1968, [Nov. 8, 1967], No.50772/67. Heading G1W. [Also in Division B8] A machine for weighing out articles from a conveyer 9, e.g. potatoes, into sacks 19, fills them alternately at ducts 17, 18 under the control of a diverter 23, and when a sack is nearly full its supply from the main part 14 of the conveyer is diverted away, and it is topped up to weight by a smaller flow from an auxiliary zone 15 of the conveyer as regulated by rotors 12. Potatoes from a hopper 2 are sorted by size, e. g. by rollers 3, 4, 5, the small ones falling outside a barrier 10 so that they are guided to the side zones 15 of the conveyer. The larger potatoes are directed via chute 16 to chutes 17a, 17b, 18a, 18b which are sequentially fed by means of diverters 22, 23 to fill four sacks in succession. The sacks stand on weighing machines 25 which control the diverters so that when a sack is, say, 90% full, it is made up to weight by small potatoes from a zone 15 fed one-at-a-time by rotors 12 to exact weight. (For Figures see next page)
Patent GB-1238597-A (GB)
IPC: A61K31/785
Filed: 1969-06-12
Abstract: 1,238,597. Antihypercholesteroleamics. UPJOHN CO. 12 June, 1969 [17 June, 1968], No. 29884/69. Heading A5B. [Also in Division C3] A pharmaceutical composition for treating hypercholesteremia comprises a polymeric reaction product of a polyethyleneimine of formula NH 2 -(CH 2 CH 2 NH) n -H, where n is from 4 to 1,000, with epichlorohydrin, glycerol- 1,3-dichlorohydrin, 1,2:3,4-diepoxybutane, bisepoxypropyl ether, ethylene glycol bis-epoxypropyl ether, 1,4-butane diol bis-epoxypropyl ether or an epoxide of formula where R is a hydrogen atom or an alkyl or phenyl group, or an acid addition salt of such reaction product, and a compatible edible oral carrier. In examples tetraethylene pentamine is reacted with epichlorohydrin and with 1,2:3,4- diepoxybutane, polyethyleneimines are reacted with epichlorohydrin, glycidol and ethylene oxide, and pentaethylene hexamine is reacted with 1,2:3,4-diepoxybutane; the reaction products are added to foodstuffs, mixed with talc and magnesium stearate and filled into gelatin capsules, mixed with soybean oil and linseed oil gelled with aluminium monostearate, and made into an aqueous suspension with pectin and deionized water. Other ingredients which may be added are mentioned.
Patent GB-1256998-A (GB)
IPC: C07F7/12
Filed: 1970-06-02
Abstract: 1,256,998. Androgen-depressant compositions. DOW CORNING CORP. 2 June, 1970 [23 July, 1969], No. 26520/70. Heading A5B. [Also in Division C3] An androgen-depressant composition suitable for oral administration comprises a cyclotrisiloxane of the formula: admixed with sesame oil.