Patent SG-11201805913Q-A (SG)
Title: New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them
Inventor: PACZAL ATTILA
IPC: C07F9/6561
Filed: 2016-12-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111011101110110111 HO HAIM III International Bureau ... ...... .Y1 j (10) International Publication Number (43) International Publication Date ..... ...,/ WO 2017/125224 Al 27 July 2017 (27.07.2017) WIPO I PCT (51) International Patent Classification: BALINT, Balizs; Lehel utca 18, 2151 Hit (HU). SIPOS, C07F 9/6561 (2006.01) A61K 31/519 (2006.01) Szabolcs; Roppentyil utca 21-23., A epillet 3/10, H-1139 A61P 35/00 (2006.01) C07D 495/04 (2006.01) Budapest (HU). A61K 31/661 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2016/081688 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, 19 December 2016 (19.12.2016) HN, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 16/50411 19 January 2016 (19.01.2016) FR TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicants: LES LABORATOIRES SERVIER [FR/FR]; 35 me de Verdun, 92284 Suresnes (FR). VER- (84) Designated States (unless otherwise indicated, for every NALIS (R&D) LIMITED [GB/GB]; 100 Berkshire Place, kind of regional protection available): ARIPO (BW, GH, Wharfedale Road, Berkshire, Winnersh Berkshire RG41 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 5RD (GB). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — (72) Inventors: PACZAL, Attila; Orjarat utca 95., H-1158 DK, EE, ES, FI, FR, GB, GR, HR, HU, IF, IS, IT, LT, LU, — _ Budapest (HU). SZLAVIK, Zoltan; Kolto utca 2-4 D/2, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = 1121 Budapest (HU). KOTSCHY, Andras; Almos Vezer SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, u.4, 2045 Torokbalint (HU). CHANRION, Maya; 14 rue GW, KM, ML, MR, NE, SN, TD, TG). = de la Galiote, Apt D441, 92130 Issy Les Moulineaux (FR). MARAGNO, Ana Leticia; 4, Allee Anastasi, 78290 Published: Croissy-sur-Seine (FR). GENESTE, Olivier; Batiment A, — with international search report (Art. 21(3)) = 17, rue Crevel Duval, 92500 Rueil Malmaison (FR). DE- = MARLES, Didier; 21 me du Lievre, 45430 Checy (FR). = (54) Title: NEW AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COM- _ = POSITIONS CONTAINING THEM = = H 3 C, , 0 N ---.-- \"* . = = I N i -: \" . '\"--,, = 1 0 = 0 - e ll R 3 R Z (I) 11 O R 4 • ii- ei ei kin ei ,-1 Y O Rl • IN ,-1 0 (57) : Compounds of formula (I): wherein R I , R, R 2 3 , R 4 , R 5 , R 6 and ei Y are as defined in the description. Medicaments. 0