baber/WOPTO huggingface dataset:
Patent AU-2013316100-B8 (AU)
Title: Antibody evolution immunogens
Inventor: HAYNES BARTON F
IPC: A61K39/12
Filed: 2013-09-12
Granted: 2018-03-08
Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
Patent BR-112013012784-B8 (BR)
Title: Método de produção de linhagem/variedade de cana-de-açúcar que apresenta teor elevado de açúcar no talo
Inventor: HIROYUKI ENOKI
IPC: A01H5/04
Filed: 2011-11-30
Abstract: MARCADOR RELACIONADO COM TEOR DE AÇÚCAR NO TALO DE CANA-DE-AÇÚCAR E USO DO MESMO. A presente invenção refere-se a um marcador relacionado com teor de açúcar no talo de cana-de-açúcar ligado a uma característica quantitativa da cana-de-açúcar. Tal marcador é relacionado com teor de açúcar no talo da cana-de-açúcar, o qual compreende uma região contínua de ácido nucleico existente em uma região tipo intercalada entre a sequência de nucleotídeo mostrada em ID SEQ NO: 1 e a sequência de nucleotídeo mostrada em ID SEQ NO: 8 ou uma região tipo intercalada entre a sequência de nucleotídeo mostrada em ID SEQ NO: 9 e a sequência de nucleotídeo mostrada em ID SEQ NO: 16.
Patent BR-112013021066-B8 (BR)
Title: Método para produzir uma composição de borracha, composição de borracha, e, pneu
Inventor: TAKESHI YUASA
IPC: C08K3/36
Filed: 2012-02-15
Abstract: MÉTODO PARA PRODUZIR UMA COMPOSIÇÃO DE BORRACHA, COMPOSIÇÃO DE BORRACHA, E, PNEU. O propósito desta invenção é fornecer uma composição de borracha com a qual um corpo elástico de borracha tendo baixa resistência ao rolamento e excelente elasticidade no impacto pode ser obtida, e um método de produção para tal. Além disso, um pneu tendo baixa resistência ao rolamento e excelente elasticidade no impacto também é divulgado. A composição de borracha de acordo com a presente invenção é obtida pela de um produto com base em dieno conjugado (A) tendo um grupo com reatividade de ligação de sílica em apenas um sítio de uma única molécula, Um polímero (B) tendo um grupo com reatividade de ligação de sílica em vários sítios de uma única molécula, e um enchedor que contenha sílica (C).
Patent BR-112015023483-B8 (BR)
Title: Uso de um inibidor de b-raf e um inibidor de mek 1/2"
Inventor: GIORDANO CAPONIGRO
IPC: A61K31/5377
Filed: 2014-03-19
Abstract: COMBINAÇÕES DE FÁRMACOS COMPREENDENDO UM INIBIDOR DE B-RAF E UM SEGUNDO INIBIDOR, SEUS USOS, E KIT DIAGNÓSTICO. A presente invenção refere-se à reversão da resistência a um inibidor de B-Raf para o tratamento de uma doença proliferativa, obtendo uma amostra do tumor do paciente e testando-a para alterações genéticas em um painel de genes compreendendo BRAF, CRAF, CCND1, CDK4, HER2, IGF-1R, cMET, FGFR1, FGFR2, FGFR3 EGFR, MAP2K1, MAP2K2, NRAS, KRAS HRAS, PTEN, PIK3CA, e P16 e administração de uma terapia de combinação de medicamentos que compreende o inibidor de B-Raf e um segundo inibidor que supera a resistência ao inibidor de B-Raf, na qual o segundo inibidor é selecionado com base em alterações genéticas, descobertas na amostra do tumor.
Patent EP-1656171-B9 (EP)
Inventor: BENNETT BRYSON
IPC: A61M11/04
Filed: 2004-08-04
Granted: 2010-10-20
Abstract: An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.
Patent EA-028755-B9 (EA)
Title: Companding system and method to reduce quantization noise using advanced spectral extension
Inventor: HEDELIN PER
IPC: H04B1/64
Filed: 2014-04-01
Abstract: Embodiments are directed to a companding method and system for reducing coding noise in an audio codec. A compression process reduces an original dynamic range of an initial audio signal through a compression process that divides the initial audio signal into a plurality of segments using a defined window shape, calculates a wideband gain in the frequency domain using a non-energy based average of frequency domain samples of the initial audio signal, and applies individual gain values to amplify segments of relatively low intensity and attenuate segments of relatively high intensity. The compressed audio signal is then expanded back to substantially the original dynamic range that applies inverse gain values to amplify segments of relatively high intensity and attenuating segments of relatively low intensity. A QMF filterbank is used to analyze the initial audio signal to obtain a frequency domain representation.
Patent AU-2001241670-B9 (AU)
Title: Automatically retraining a speech recognition system
Inventor: FANTY MARK
IPC: G10L15/07
Filed: 2001-02-23
Granted: 2001-09-03
Abstract: A telephone-based interactive speech recognition system is retrained using variable weighting and incremental retraining. Variable weighting involves changing the relative influence of particular measurement data to be reflected in a statistical model. Statistical model data is determined based upon an initial set of measurement data determined from an initial set of speech utterances. When new statistical model data is to be generated to reflect new measurement data determined from new speech utterances, a weighting factor is applied to the new measurement data to generate weighted new measurement data. The new statistical model data is then determined based upon the initial set of measurement data and the weighted new measurement data. Incremental retraining involves generating new statistical model data using prior statistical model data to reduce the amount of prior measurement data that must be maintained and processed. When prior statistical model data needs to be updated to reflect characteristics and attributes of new speech utterances, statistical model data is generated for the new speech utterances. Then the prior statistical model data and the statistical model data for the new measurement data are processed to generate the new statistical model data.
Patent AU-2015317622-B9 (AU)
Title: Multifunctional protein molecular weight ladders
Inventor: PADHYE NISHA
IPC: G01N33/53
Filed: 2015-09-17
Granted: 2021-04-01
Abstract: Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of Formula I (e.g., mono acetylated MP-1 1 NHS ester) that may be used to label purified proteins of the protein ladder. The MP-1 1 label protein ladder can be detected on a blotting membrane by exposing the microperoxidase to a suitable substrate, such as a chromogenic substrate or a chemiluminescent substrate.
Patent AU-2018363611-B9 (AU)
Title: Method and kit for sample preparation and endotoxin determination
Inventor: BUCHBERGER ANDREAS
IPC: G01N33/579
Filed: 2018-11-02
Granted: 2021-11-25
Abstract: The invention relates to a method for preparation of a sample (10) of a formulation (11) for subsequent endotoxin determination, the formulation (11) suspected of comprising an endotoxin, the formulation (11) preferentially being a pharmaceutical formulation. The method comprises the following steps: application of the sample (10) to an endotoxin-free centrifugation column (2) containing a size exclusion chromatography matrix (5) that has been equilibrated with a suitable equilibration buffer (6) and elution of a flow through (15) of the sample by centrifugation, which flow through (15) can then be used for endotoxin determination. The equilibration buffer (6) is selected according to a subsequently used method of endotoxin determination, the equilibration buffer (6) only containing components not interfering with subsequently used method of endotoxin determination. Furthermore, the invention relates to a kit (20) for preparation of a sample (10).
Patent BR-PI0316895-C1 (BR)
Inventor: RAMA SASTRI KAMBHAMPATI
IPC: C07D513/04
Filed: 2003-12-16
Abstract: Tetracyclic 3-substituted indoles having serotonin receptor affinity and pharmaceutically acceptable salts thereof.
Patent BR-9606486-C1 (BR)
Title: Aperfeiçoamento em aparelho salva-vidas equipado com um dispositivo de lançamento.
Inventor: REAL JOSEP ANTONI BAUTISTA
IPC: B63C9/18
Filed: 1996-03-01
Abstract: "APERFEIçOAMENTOS EM APARELHO SALVA-VIDAS EQUIPADO COM UM DISPOSITIVO DE LANçAMENTO". O objetivo da presente invenção são os aperfeiçoamentos introduzidos em um aparelho salva-vidas equipado com um lançador que oferece a possibilidade de imediata inflação da bóia salva-vidas, de controlar a distância à qual o mesmo deve ser lançado graças a recursos afixados ao lançador, os recursos sendo uma tabela de distâncias métricas (28) e de uma mira telemétrica (27), sendo afixada à bóia (1) e ao dispositivo lançador por intermédio de um sistema de linhas (21) e (23) que oferece a possibilidade de ligar a bóia (1) com a gaiola porta rolo de linhas (25) do lançador, no interior do bocal (13) do qual a bóia (1) é inserida.
Patent DE-3320052-C1 (DE)
Title: Multiple-link accelerator pedal for vehicles
Inventor: PAPENHAGEN DIETER
IPC: B60K26/02
Filed: 1983-06-03
Granted: 1984-10-04
Abstract: The invention relates to a multiple link accelerator pedal for vehicles, the bottom end of which is connected by way of a connecting part to the splash wall of the vehicle. The connecting part is designed as a strip of links which has transverse impressions regularly distributed over its length. The accelerator pedal and the connecting part are not supported on the floor defining the footwell.
Patent DE-3406859-C1 (DE)
Title: Device for very deep freezing of objects
Inventor: SEIDEL ALBERT DIPL-ING
IPC: F17C3/08
Filed: 1984-02-25
Granted: 1985-04-04
Abstract: A device 1 for the very deep freezing of objects with superfluid helium II as a refrigerating agent, in which the storage container 2 for the helium II is surrounded by radiation shields 3, 4 and 5 cooled by waste gas and a vacuum shell 6, is intended to work in autonomous operation for a limited time without vacuum pump. To this end, there is installed additionally on or in the innermost radiation shield 3 an additional tank 3 which surrounds the storage container 2 and is filled with normal liquid helium I. <IMAGE>
Patent DE-3413917-C1 (DE)
Inventor: KORDAS FRIEDEL
IPC: B01D46/02
Filed: 1984-04-13
Granted: 1985-06-20
Abstract: 1. Apparatus for dissolving layers of dust (56) on the inside of the walls (17) of cylindrical and conical filter housings (10, 18) by blasting with compressed gas (50) or compressed gas mixture in the case of dust filters with filter elements (14) which are open at the top, are secured with their open end (15) to a separating base (13) between the dust gas and the clean gas chamber and disposed on a circular surface, the encompassing diameter of which is smaller than the inner diameter of the filter housing (10), characterised in that a mounting frame (30) is rotatably mounted about the middle axis of the filter housing (10) between the filter elements (14) and the inside of the housing wall (17), the mounting frame (30) being composed in the axial direction of straight and in the circumferential direction of conically bowed hollow profiles, such as tubes (31, 32) for example, whereby at least two of the straight tubes (31) are connected to their lower ends with at least one bow-shaped tube (35) parallel to and at a distance from the conical housing wall (18), at least one of the tubes (31) which extend in the axial direction of the filter housing (10) and at least one leg of the bow-shaped tube (35) being passed through by compressed gas (50) and being provided with nozzle-shaped blowing apertures (33) for the compressed gas (50) directed towards the inside of the housing walls (17, 18).
Patent DE-3603475-C1 (DE)
Title: Fillable toothbrush
Inventor: HERTRAMPF MICHAEL DR
IPC: A46B11/00
Filed: 1986-02-05
Granted: 1987-07-02
Abstract: A fillable toothbrush has a handle containing a chamber for a tooth cleaning agent and a stem on one end. A channel extends through the stem from the chamber to an outlet opening in the region of bristles located at the free stem end. The other end of the handle is provided with an actuation member for actuation of a pump unit located between the chamber and the channel, the pump unit having a valve facing the supply chamber in the closing direction. The chamber for a tooth cleaning agent contains a holder whose volume can be changed slightly and which has an opening whose edge is tightly connected to an inner wall of the chamber. A venting orifice extends from this chamber into the environment. The holder may be, for example, of bellows shape. It prevents the tooth cleaning agent from drying out or escaping through the venting orifice (drawing). <IMAGE>
Patent DE-3632104-C1 (DE)
Title: Self-locking differential, particularly for motor vehicles
Inventor: F SCHMID LEOPOLD
IPC: F16H48/29
Filed: 1986-09-20
Granted: 1988-01-21
Abstract: Since, with the present state of the art, there is as yet no self-locking differential which, when installed in the front axle of a passenger vehicle with front-wheel drive, does not impair the ease of steering, the invention proposes an embodiment which is free from all disadvantageous effects on the ease of steering. It is characterised by the combination of a nowadays customary bevel-gear differential with parts of a likewise already known lock-up device, this combination being effected by means of worms and worm wheels, thereby achieving a new and hitherto unknown mode of action.
Patent DE-3717735-C1 (DE)
Title: Non-return valve for a plastication screw
Inventor: EICHLSEDER MARTIN
IPC: B29C45/52
Filed: 1987-05-26
Granted: 1988-02-18
Abstract: In the case of a non-return valve for the plastication screw of a plastics injection moulding machine, there is the problem that the spacers provided for maintaining a predetermined clearance between a locking ring (9) guided in the barrel (1) and the screw head (3) are subject to wear and therefore have to be frequently exchanged. To be able to avoid the exchange of the spacers, in particular balls (14), as far as possible, the spacers consist of ceramic, preferably surface-polished material, which is largely wear-resistant. <IMAGE>
Patent DE-3807674-C1 (DE)
IPC: E04H4/12
Filed: 1988-03-09
Granted: 1989-04-06
Abstract: The invention relates to an outlet for perimeter gutters of swimming pools or the like, consisting of an outlet opening (5) which is located inside the perimeter gutter (2) and to which an intermediate pipe (6), connectable to an outlet conduit (12), is sealingly connected. In order to provide an outlet for perimeter gutters of swimming pools or the like in which gurgling noises no longer arise and the occurrence of jets of water is eliminated, an outlet box (11) is arranged between the intermediate pipe (6) and the outlet conduit (12), and the outlet box (11) is connected to the perimeter gutter (2) by a ventilation channel (8) which leads into the perimeter gutter (2) above the outlet opening (5). <IMAGE>
Patent DE-3815745-C1 (DE)
Title: Gas-insulated metal-encapsulated switching installation
IPC: H02B5/06
Filed: 1988-05-09
Granted: 1989-06-08
Abstract: Gas-insulated metal-encapsulated switching installation are intended to be designed so that they need the smallest possible installation area. An improvement can be achieved by arranging the busbar 3 in two planes. In this case, the busbar sections 10, 20, 30... lie alternately, on the one hand, on the lower plane 2 and, on the other hand, on the upper plane 1. Horizontal connections 3'' and/or vertical connections 3''' join these busbar sections together. The vertical connections 3' and/or the horizontal connections 3'' or 3''' respectively are employed for accommodating sectionalising switch disconnectors 5 and other electrical equipment 7. Longitudinal sections for accommodating the electrical equipment could in this way be saved or designed, such that the constructional length of the arrangement could be substantially shortened in comparison with known arrangements. <IMAGE>
Patent DE-3835142-C1 (DE)
Title: Anti-theft protection for motor vehicles, in particular for passenger cars
IPC: B60R25/04
Filed: 1988-10-15
Granted: 1990-03-15
Abstract: An anti-theft protection for passenger cars has an ignition lock (1) which is connected via a battery line (2) to the battery (6) of the motor vehicle and via a starting line (3) to the starter (9) of the motor vehicle. The starting line (3) is connected to the battery line (2) in the ignition lock (1) when an ignition key is turned to a predetermined position in a lock switch (18) of the ignition lock (1). An electric circuit (20) in the ignition lock (1) has an encoder (20). A decoder (25) with a relay switch (19) is arranged in the vicinity of the starter (9). The encoder (20) is connected to the decoder (25) by a security line (4). The relay switch (19) is connected in series with the lock switch (18) in the starter circuit. When the ignition key assumes the predetermined position in the lock switch (18), a pulse sequence occurs at the output (23) of the encoder (20) which is connected to the security line (4). The decoder (25) then closes the starter circuit, interrupted by the open relay switch (19), for a predetermined time when the predetermined pulse sequence is present at the input (26) of the decoder (25). <IMAGE>
Patent DE-3906576-C1 (DE)
IPC: B62D1/06
Filed: 1989-03-02
Granted: 1990-06-13
Abstract: The invention relates to a steering wheel with electrical heating and a process for its manufacture. In a first embodiment of the invention, a heating conductor of spring wire (7) is used which is embedded in an external region of the steering wheel jacket with outwardly directed spring force and is wound in such a way that it has continuous, clip-like open windings (8). As a result of this design of the spring wire (7), it rests during the foaming process against the inside of the torus-shaped foam ring (5) during manufacture in such a way that it is thus held in the desired position and does not have to be wound about the steering wheel core (6) with individual windings. In a further embodiment, the heating conductor is formed by the jacket consisting of foamed material into which conductor particles are introduced in a suitable amount. 
<IMAGE>
Patent DE-3927996-C1 (DE)
IPC: B65B3/16
Filed: 1989-08-24
Granted: 1991-01-24
Abstract: Small quantities of prepared ointments or of corresponding pasty masses (10) are mostly filled into ointment tubs, in which the durability of the ointment is only relatively short, or into tubes (1). Filling into a tube takes place with a filling device which has to be cleaned, or with a plastic apron (3) intended for a single use, the ointment moistening, however, the inner, still open bottom end (2) of the tube and the squeezing together of this end requiring skill. Also with this device, tubes which have a latex ring cannot advantageously be used. An ointment is filled into a thin plastic apron (3) intended for a single use and is introduced by means of the same into the tube (10), a part of the plastic apron which has not been moistened by the ointment being brought, during its introduction, over the inner region of the bottom end so that this region is protected against moistening with the ointment. Manual filling of tubes with a pasty mass, in particular in dispensing. <IMAGE>
Patent DE-4038075-C1 (DE)
Title: Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
IPC: A61K9/127
Filed: 1990-11-29
Granted: 1992-03-19
Abstract: Process for encapsulating solid or liq. lipophilic agents (I) in a hydrating medium in phospholipid liposomes comprises mixing 1/2 - 3/4 of the amount of the hydration medium with the phospholipid (mixt.) with stirring to disperse the phospholipid; raising the temp. to above the phase change temp. of the soln. where the (I) is added to the dispersion, and the remaining hydration medium is added; and continuing to stir the mixt. at this temp. until no more free (I) can be detected in the hydration medium. The process is carried out in an inert atmos. The hydration medium is free of organic solvent and detergent. After the first step is complete, the liposomes are adjusted to the required size. Pref. the phospholipid is phosphatidytcholine, ethanolamine etc. and the active agent is an antibiotic, hormone, tranquiliser etc.
Patent DE-4302549-C1 (DE)
Title: Folding headrest for car rear seat - has height-adjustable bar detachable from guide in lowermost position for folding into rest position
Inventor: GEISEL THOMAS DIPL ING
IPC: B60N2/48
Filed: 1993-01-29
Granted: 1994-02-17
Abstract: The headrest cushion is secured to a bar sliding in a guide for height adjustment. In its lowermost position, the bar (3) is detachable from the guide (7) to allow folding into the rest position. In this position it can fit detachably in a bearing fixed to the car bodywork. Adjustment can be by a rack (9) engaging with the bar and clear of th bearing, and which also causes the bar to pivot. The bar can be spring-loaded into the rest position by a spring (16) acting between it and th rack. ADVANTAGE - Wide range of height adjustment, while occupying minimum amount of space in rest position.
Patent DE-4322075-C1 (DE)
Title: Detachable ventilation means for a vehicle
Inventor: KARUTZ STEPHAN DR
IPC: B60J1/20
Filed: 1993-07-02
Granted: 1995-03-16
Abstract: In hot weather camping vehicles, such as motor homes (mobile homes) or caravans (recreational trailers) are sufficiently ventilated only if the wind strikes against a window opening, i.e. against the side of the vehicle. Should the wind blow past the side of the vehicle the interior is not adequately ventilated. The detachable ventilation means for a vehicle makes it possible, in this case, for the vehicle interior to be well ventilated. The detachable ventilating means for a vehicle comprises a dome-shaped fabric casing which is open at the front and at the base and is held in shape by means of a linkage of rods. This is fastened in such a manner to a window opening of the vehicle that its open front faces the wind and its open base lies over the window opening. The wind is then trapped by the dome of the detachable ventilating means and diverted into the interior of the vehicle. The detachable ventilating means for a vehicle can be folded up particularly small because of its construction. Ventilation of vehicles, in particular camping vehicles.
Patent DE-4327525-C1 (DE)
Title: Optical connector and method for the production of an optical connector
Inventor: KUCHENBECKER THOMAS DIPL ING
IPC: G02B6/38
Filed: 1993-08-11
Granted: 1994-09-15
Abstract: In a separate front part (25), coupling end pieces (20, 21) having axial holes (22, 23) are mounted. A cable end (3) having two optical fibres (8, 9) is fixed in a main part (1), the ends (10, 11) of which optical fibres (8, 9) project on the side of the front part and are arranged, with their axes parallel, at the distance (29) of the axial holes (22, 23). The front part (25) can be displaced perpendicularly to the fibre ends (10, 11) for the purpose of orienting the axial holes (22, 23) and the fibre ends (10, 11) so that they align. <IMAGE>