Patent SG-11201804496U-A (SG)
Title: Recombinant zika vaccines
Inventor: TAUBER ERICH
IPC: C07K14/005
Filed: 2016-12-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date ..... ...sr ,„,„1 29 June 2017(29.06.2017) WIPO I PCT ID Hit (10) 111111111111111111Ill WO International IIIII 2017/109222 Publication 1111111111111111111111111111111 Al Number RIO IIII IIIIIIII (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 39/12 (2006.01) C07K 14/005 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/EP2016/082659 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 23 December 2016 (23.12.2016) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 15202480.8 23 December 2015 (23.12.2015) EP kind of regional protection available): ARIPO (BW, GH, 16162688.2 29 March 2016 (29.03.2016) EP GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: THEMIS BIOSCIENCE GMBH [AT/AT]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Muthgasse 11/2, 1190 Vienna (AT). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: TAUBER, Erich; Tullner Strasse 16, 3426 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Muckendorf (AT). SCHRAUF, Sabrina; Weingartenweg GW, KM, ML, MR, NE, SN, TD, TG). 1, 7072 Morbisch Am See (AT). MULLNER, Matthias; RehstraBe 9, 3441 Pixendorf (AT). RAMSAUER, Katrin; Declarations under Rule 4.17: Loimerweg 10A/2, 1220 Vienna (AT). IRMLER, An- of inventorship (Rule 4.17(iv)) gelika; Carabelligasse 8, 1210 Vienna (AT). CSAR, Published: Patrick; Rieslinggasse 10, 3433 Konigstetten (AT). (74) Agent: EISENFUHR SPEISER PATENTANWALTE — with international search report (Art 21 ( 3 )) RECHTSANWALTE PARTGMBH; P.O. Box 31 02 60, _ with sequence listing part of description (Rule 5.2(a)) 80102 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, Il .4t N N (54) Title: RECOMBINANT ZIKA VACCINES CT\ 0 (57) : The present invention relates to the provision of immunogenic or vaccine compositions comprising at least one 11 ---- re- combinant Zika virus antigen, wherein the at least one recombinant Zika virus antigen is encoded by at least one nucleic acid se - L -- quence encoding at least one E-protein of a Zika virus or a functional fragment thereof. Further provided are nucleic acid molecules ::::, and a recombinant chimeric virus encoding and/or comprising selected antigens from a Zika virus, which are suitable as vaccine ei compositions. Preferably, the sequences encoding at least one Zika virus antigens suitable for eliciting an immune response are oper- 0 ably linked to a non-flavivirus derived vector backbone. Further provided are methods for purifying the recombinant chimeric virus particles or the immunogenic composition. Finally, there is provided an immunogenic/vaccinecomposition for use in a method of preventing or treating a Zika virus disease.