baber/WOPTO huggingface dataset:
Patent MX-2021005924-A (MX)
Title: Compounds and methods of use thereof for treatment of cancer.
Inventor: LIU YUAN
IPC: C07D487/10
Filed: 2019-11-27
Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein A, B, R<sup>1</sup>, R<sup>3</sup>, L<sup>1</sup>, L<sup>2</sup>, L<sup>3</sup>, E, A<sup>1</sup>, A<sup>2</sup>, A<sup>3</sup>, A<sup>4</sup>, G<sup>1</sup>, G<sup>2</sup>,W, X, Y, Z, m1, m2, n1, and n2 are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
Patent MX-2021009803-A (MX)
Title: Evaporator assembly for ice-making apparatus and method.
Inventor: ROTH KEITH H
IPC: F25C1/04
Filed: 2017-04-19
Abstract: Evaporator assembly for an ice-making apparatus having a vertical, substantially flat freeze surface, a refrigerant circuit, and a freeze template. The freeze template is thermally coupled between the freeze surface and the refrigerant circuit, and is formed of regions arranged in a plane and interconnected by strips having a smaller dimension in the plane than the regions. Interface locations between the freeze template and the freeze surface define where on the freeze surface ice is formed. During a freeze cycle, expanded refrigerant is passed through the refrigerant circuit, and water is run over the freeze surface. During a harvest cycle, compressed refrigerant is passed through the refrigerant circuit, wherein heat transfers from the refrigerant circuit to the freeze surface until the freeze surface is warmed to a temperature sufficient to allow ice formed on the freeze surface to fall from the freeze surface by a force of gravity.
Patent MX-2021014054-A (MX)
Title: Methods and cells for production of phytocannabinoids and phytocannabinoid precursors.
Inventor: MOOKERJEE SHOHAM
IPC: C12N15/54
Filed: 2020-05-21
Abstract: The present disclosure relates generally to methods and cell lines for the production of phytocannabinoids, phytocannabinoid precursors or intermediates, or phytocannabinoid analogue. Methods for transformation of host cells, such as yeast cells, are described. Cells may be transformed, for example, with a polynucleotide encoding a polyketide synthase (PKS) enzyme, a polynucleotide encoding an olivetolic acid cyclase (OAC) enzyme, and/or a polynucleotide encoding a prenyltransferase (PT) enzyme; and optionally a polynucleotide encoding an acyl-CoA synthase (Alk) enzyme; a polynucleotide encoding a fatty acyl CoA activating (CsAAE) enzyme; and/or a polynucleotide encoding a THCa synthase (OXC) enzyme.
Patent MX-2021015302-A (MX)
Title: Antibody purification methods and compositions thereof.
Inventor: DOLAN MICHAEL E
IPC: G01N33/00
Filed: 2020-06-10
Abstract: Methods of purifying a humanized Î±4Î²7 antibody, such as vedolizumab, produced in a mammalian cell culture are described herein, as are compositions resulting from said purification processes.
Patent MX-2022000052-A (MX)
Title: System for enhancing therapeutic compliance of the anti-cancer compound e7766.
Inventor: JIANG RONGRONG
IPC: A61K31/7084
Filed: 2020-07-01
Abstract: Systems for reducing medication error and enhancing therapeutic compliance of an individual suffering from cancer are reported. Embodiments provide information on drug-drug interaction for dosage of anti-cancer therapeutic Compound 1 (E7766) in possible combination with an OATP inhibitor.
Patent MX-2022000384-A (MX)
Title: Beverage dispenser with beverage-level indicator.
Inventor: MOSKOWITZ STEVEN PHILIP
IPC: G01F23/22
Filed: 2020-06-25
Abstract: A beverage dispenser having a beverage-level indicating system. The beverage dispenser includes a housing and a dispensing head arranged on the housing for dispensing a beverage into a beverage container. The beverage dispenser further includes a beverage-level sensor arranged on the housing and which determines a beverage level within the beverage container without contacting the beverage within the beverage container, a beverage-level indicator that provides a visual indication of the beverage level within the beverage container, and a control unit that causes the beverage-level indicator to indicate the beverage level within the beverage container based on the beverage level as determined by the beverage-level sensor.
Patent MX-2022002206-A (MX)
Title: Signal allocation in a carrier.
Inventor: Wallén Anders
IPC: H04L5/00
Filed: 2020-08-20
Abstract: The disclosure relates to configuring of at least two signals. Each of the two signals have a frequency bandwidth which is less than a system frequency bandwidth available to the network node for wireless transmissions. The method comprises allocating a first signal of the two signals on a first time and frequency resource based on a configuration in which the first signal is included, allocating a second signal of the two signals on a second time and frequency resource based on the configuration, wherein frequency use of the second time and frequency resource is at least partly different from frequency use of the first time and frequency resource, and providing signalling for a wireless communication device enabling the wireless communication device to derive the first and second time and frequency resources. The allocating of the first and second signals includes allocating another time and frequency resource adjacent in time or frequency to at least one of the first and the second signals. The another time and frequency resource is allocated closer to a boundary of the system frequency bandwidth than the first and second time and frequency resources.
Patent MX-2022002639-A (MX)
Title: System and method to efficiently clean a blood filter.
Inventor: ROHDE JUSTIN
IPC: A61M1/16
Filed: 2015-07-07
Abstract: A method for cleaning a blood filter includes: (i) pumping a physiologically safe fluid back and fourth through the insides and/or the outsides of a plurality of hollow fiber membranes of the blood filter to remove or loosen blood residuals, such as blood clots, proteins and/or biological fluid; (ii) injecting air into the physiologically safe fluid to form an air/fluid mixture; (iii) pumping the air fluid mixture through the insides and/or outsides of the plurality of the hollow fiber membranes of the blood filter to further or remove or loosen blood residuals therefrom; and (iv) removing the air/physiologically safe fluid mixture along with the removed or loosened blood residuals to drain.
Patent MX-2022005500-A (MX)
Title: Mobility optimization method and related apparatus.
Inventor: ZHANG HONGPING
IPC: H04W36/08
Filed: 2020-02-20
Abstract: Embodiments of the present application disclose a mobility optimization method and a related apparatus. The method comprises: in a mobility enhancement scenario or an MCG RLF in a dual connectivity scenario, a terminal device reporting connection failure information to a network side, wherein the connection failure information is used to indicate an RLF or a handover failure; upon receipt of the connection failure information, a network device on the network side determining that the type of the connection failure of the terminal device is too late handover, too early handover or handover to a wrong cell. After the network device on the network side determines the type of the connection failure of the terminal device, mobility parameter optimization can be performed. By means of the embodiments of the present application, in mobility enhancement and/or MR-DC, too late handover, too early handover or handover to a wrong cell can be determined, realizing mobility parameter optimization, thereby optimizing mobility robustness.
Patent MX-2022007615-A (MX)
Title: Polyester composition.
Inventor: VENDERBOSCH ROBERT WALTER
IPC: C08L67/02
Filed: 2020-12-17
Abstract: The invention relates to a composition comprising A) a polyester, B) a polyolefin and C) a compatibilizer, wherein C) is a functionalized polyolefin containing hydroxyl functional groups or a reaction product of the functionalized polyolefin and a polyester, wherein the total amount of A) and B) with respect to the total composition is at least 77 wt% and the amount of C) with respect to the total composition is 0.1 to 23 wt%.
Patent MX-2022009353-A (MX)
Title: Structural optimization method to improve the theranostic performance of peptide receptor-targeted radionuclide therapy for cancers.
Inventor: Lee Dongyoul
IPC: A61K51/08
Filed: 2021-01-28
Abstract: The present invention provides in certain embodiments a carcinoma-targeting conjugate comprising Formula I wherein T is a SST2R targeting ligand, L is a linker, and X is a chelator, for the therapeutic treatment of cancer, and methods of use thereof.
Patent MX-2022009354-A (MX)
Title: Coil-in-coil springs with non-linear loading responses and mattresses including the same.
Inventor: THOMAS DARIN T
IPC: A47C27/06
Filed: 2018-07-20
Abstract: A coil-in-coil spring is provided that exhibits a variable and non-linear loading response. The spring includes a first spring portion having a first spring constant, a second spring portion having a second spring constant less than the first spring constant, and a third spring portion having a third spring constant less than the first spring constant and less than the second spring constant. The first spring portion forms an outer coil of the coil-in-coil spring and the second spring portion, the third spring portion, or both the second spring portion and the third spring portion are positioned within the first spring portion and form an inner coil of the coil-in-coil spring. A multi-coil spring is also provided that includes an outer coil, an intermediate coil positioned within the outer coil, and an inner coil positioned with the intermediate coil.
Patent MX-2022010044-A (MX)
Title: Pharmaceutical composition comprising sustained-release microspheres including glp-1 analogue or pharmaceutically acceptable salt thereof.
Inventor: LEE HEEYONG
IPC: A61K9/16
Filed: 2021-02-15
Abstract: The present invention relates to a pharmaceutical composition that can effectively suppress fatal side effects by preventing rapid initial bursting of a drug by including sustained-release microspheres containing semaglutide, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and can minimize the pain and inflammatory reaction of a patient, which may occur during administration, by containing a high amount of drug relative to the particle size, and thus can be useful in the prevention or treatment of diabetes, beta-cell function preservation, hypertension, hyperlipidemia, obesity, nonalcoholic steatohepatitis, or neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
Patent MX-2022011309-A (MX)
Title: T cell receptors.
Inventor: TRIBBLE NICHOLAS
IPC: C07K14/725
Filed: 2018-10-05
Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.
Patent MX-2022013288-A (MX)
Title: Compositions and methods for the treatment of tdp-43 proteinopathies.
Inventor: KOYA KEIZO
IPC: C07K14/47
Filed: 2021-04-27
Abstract: A novel class of fusion proteins to recruit a cell's innate chaperone mechanism, specifically the Hsp70-mediated system, to specifically reduce TDP-43-mediated protein aggregation and associated proteopathies is disclosed.
Patent MX-PA00007843-A (MX)
Title: Hollow camshaft for internal combustion engines.
Inventor: EUGENIO GARCIA MARTINEZ
IPC: F01L1/047
Filed: 2000-08-10
Abstract: A hollow camshaft is produced which is reduced in mass and weight at least 30% less than a solid camshaft. The hollow camshaft is made as a single piece, offering the same function and meeting all the specification of a solid camshaft. The cast hollow camshaft is produced by lost foam, no bake, green sand, shell sand or any other molding system. This design also meets all OEM specifications for a camshaft and its required supporting stresses and torsional loads. The hollow camshaft has a minimum wall thickness of five millimetres which can heat treatment, by flame or induction heat.
Patent MX-PA01002185-A (MX)
Title: Electrically conductive pipe clip or cable clip.
Inventor: DAUME BRITTA
IPC: H01R4/66
Filed: 1999-09-13
Abstract: The invention relates to a device (2) for contacting a pipe or -able in an electrically conductive manner. The inventive device comprises a base body (4) for placing on the body (42) to be contacted, and has a contact element (40) which is held on a side of the base body (4) that, when assembled, faces the body to be contacted. Said contact element is provided for producing an electrically conductive connection with the body (42) to be contacted. According to the invention, adjusting means are provided for adjusting the position of the contact element (40) with regard to the edges of the base body (4).
Patent MX-PA01002780-A (MX)
Title: Method of manufacturing a battery.
Inventor: TSUYOSHI SUGIYAMA
IPC: H01M50/618
Filed: 2001-03-16
Abstract: To provide a method of manufacturing a battery capable of enhancing productivity and preventing deterioration of the battery performance. After attaching a positive electrode terminal to a belt-shaped electrode, electrolyte layers are formed. This can decrease the number of manufacturing processes after forming electrolyte layers, which effectively prevents that solvents in the electrolyte evaporates or the electrolyte layers are absorbed the water. Thereby, manufacturing yields of the battery can be enhanced, Additionally, a battery excellent in discharge capabilities and stable in voltage can be attained.
Patent MX-PA01006329-A (MX)
Title: Active oxygen scavenger packaging.
Inventor: CAHILL PAUL J
IPC: C08G69/46
Filed: 1999-11-16
Abstract: Improved active oxygen scavenging packaging articles optionally further comprising SiO2 and/or EAA coatings are disclosed. Also improved active oxygen scavenging copolycondensates and their use in packaging articles are disclosed. Specifically disclosed are (1) the use of an oxidation moderator or controller (anti-oxidant) along with the copolycondensate scavenger and (2) post polymerization treatment of the copolycondensate substantially in the absence of oxygen. The improvements lead to increased oxygen consumption by the active oxygen scavenger and improved packaging characteristics for the active oxygen scavenging copolycondensates.
Patent MX-PA01008275-A (MX)
Title: Adjustable angle spindle.
Inventor: SOMPPI KERRY ARNE
IPC: G01M17/02
Filed: 1999-02-18
Abstract: An apparatus and method for making possible an infinite variation in the adjustment angle of a spindle assembly makes possible a rapid changeover for testing the dynamic properties of elastomeric objects. In spindle assembly (10), wedge rings (18, 20) having wider portions (22, 22a) and narrower portions (24, 24a) interposed between a spindle (12) and an axle assembly (17), whereby the relative placement of the wider portions (22, 22a) and the narrower portions (24, 24a) determine the angle of the spindle (12) relative to axle assembly (17). Indicia (48, 48a) on the wedge rings (18, 20) make possible quick determination of the exact angle. Means (50, 50a, 67) may be provided to make easier rotation of the wedge rings (18, 20).
Patent MX-PA01012654-A (MX)
Title: Method and apparatus for using frame energy metrics to improve rate determination.
Inventor: LEVIN JEFFREY A
IPC: H04L25/02
Filed: 2000-06-09
Abstract: A Wireless Code Division Multiple Access method and apparatus for determining the transmitted rate of a voice/data signal from a mobile station to a Base Station. Variable rate vocoders transmit voice at one of several predetermined frame rates. The receiver determines the transmitted rate based on one of several frame parameters. One of the parameters is received frame energy. The received frame energy is measured over the length of the relevant portion of the frame. Energy is measured over the half of the frame that can only contain energy if a full rate frame is sent. If the energy measured exceeds a threshold, then full rate is indicated. Else, energy is measured over the fourth of a frame that can only contain energy if a half rate frame is sent. If the energy exceeds a threshold, then half rate is indicated. The procedure is repeated for quarter and eighth
Patent MX-PA02001336-A (MX)
Title: A dispensing device comprising a reservoir and attachment means provided with protected piercing means.
Inventor: RICCI PATRIZIO
IPC: B05B15/00
Filed: 2000-07-28
Abstract: The present invention is directed to a device comprising an appliance, and a reservoir suitable for being removably connected to said appliance, said appliance comprising at least one piercing means and said reservoir comprising one pierceable means, said appliance comprising a releasable protecting means for preventing access to said piercing means when said reservoir is not connected to said appliance. The present invention is further directed to said appliance, and also to said reservoir. In a preferred embodiment of the invention, the appliance comprises an actuation trigger to release said protecting means and give access to said piercing means, and said reservoir comprises a releasing means to cooperate with said actuation trigger in releasing said protecting means. Also preferably, said appliance and said reservoir are provided with cooperating securing means, so as to ensure that said reservoir is secured into said appliance, ones connected thereinto.
Patent MX-PA02001556-A (MX)
Title: Adjustable-backset latch system for locksets, and method.
Inventor: WINARDI MICHAEL
IPC: E05B55/00
Filed: 2000-08-11
Abstract: An adjustable-backset latch system for a lockset includes three main subsystems; a bolt retraction system (12), a backset-adjustment system (14), and a deadlatching system (16). By virtue of thesimplicity of the design of the backset adjustment subsystem, theuser can change the backset from 2-3/8'' to 2-3/4'', and vice-versawith one hand. A pin (76) is simply moved through a "U"-shaped slot (68) formed in a housing (34) and the housing and bolt actuation components are extended simultaneously by the desired backset increment. The bolt retraction system of the present invention uses a cam (40) in which the distance from a point (42) about whichthe cam rotates and the end of the cam, and the distance to a smaller cam pin (46), are selected to multiply the relatively small angular distance transversed during a half-round rotation of the knob or handle into the desired retraction distance of a main bolt. The deadlatching system uses two springs (52, 54), one of which not only biases an auxiliary bolt (20) to its extended position, but also biases a deadlocking dog (118) so as to pivot into a blocking position preventing the main bolt from being retracted completely, in the event an intruder attempts to move the bolt.
Patent MX-PA02003459-A (MX)
Title: Chromium histidine complexes as nutrient supplements.
Inventor: ANDERSON RICHARD A
IPC: A23K20/195
Filed: 2000-10-06
Abstract: Chromium is an essential element which has been shown to have beneficial effects on carbohydrate and lipid metabolism. Often, dietary intake is suboptimal, and nutritional supplements may not be effective due to poor absorption in the gastrointestinal tract. A novel chromium histidine complex has been prepared which significantly improves absorption capability over current available chromium nutritional supplements. The complex is safe, easily prepared and may be combined with an ingestible carrier for consumption as a tablet, capsule, aqueous solution, food or food product.
Patent MX-PA02007718-A (MX)
Title: High pressure low volume pump.
Inventor: DE TALHOUET PHILIPPE
IPC: G01N30/32
Filed: 2001-11-30
Abstract: A piston carrier (46) supports an elongated, slender piston rod (2) for reciprocation in a pump cylinder (30) to pump fluid into and out of the cylinder (30). The piston rod (12) is made of a material such as sapphire or zircon and has a diameter less than about ten millimeters, and the pump can provide flows of from about 50 nanoliters to about 250 microliters per minute at pressures of several hundred bars. A drive motor (18) rotates a threaded screw (58) and a drive nut (70) of a drive system (26) applies a linear drive force to the piston carrier (46). A ball and socket connection (74) between the drive system (26) and the piston carrier (46) avoids the need for precise alignment to prevent breakage of the fragile piston (12). A magnet (80) in the socket (78) holds the ball (76) in place and avoids the need for a spring or other mechanical holder. The socket (78) also includes a ring (88) of a low reluctance material surrounding the ball (76) to increase the magnetic retention force.
Patent MX-PA02008687-A (MX)
Title: Apparatus for transferring a discrete portion of a first web onto a second web.
Inventor: HILT RONALD ALEX
IPC: B65C9/22
Filed: 2001-03-02
Abstract: This invention relates to an apparatus for transferring a discrete portion of a first web traveling at a first speed onto a second web traveling a second speed. The apparatus includes a converting mechanism capable of forming at least one discrete portion out of the first web. An anvil roll is positioned in close proximity to the converting mechanism and can travel at a rotational speed equal to the first speed. The anvil roll is a vacuum roll that is capable of directing the discrete portion away from the converting mechanism. A transfer roll is arranged in close proximity to the anvil roll and initially travels at a rotational speed equal to the first speed. The transfer roll forms a gap with the anvil roll through which the discrete portion can pass. The transfer roll is also a vacuum roll that is capable of directing the discrete portion away from the anvil roll. The transfer roll is capable of changing rotational speed to match the second speed during a single revolution. A backing roll is arranged in close proximity to the transfer roll and travels at a rotational speed equal to the second speed. The backing roll cooperates with the transfer roll to combine the discrete portion with the second web.
Patent MX-PA02009726-A (MX)
Title: Pre-filled syringe.
Inventor: HENDERSON MALCOLM JOHN
IPC: A61M5/28
Filed: 2001-03-28
Abstract: A pre-filled syringe comprising a glass barrel (1), a sealing member (5) fitted in a medical liquid discharge port (11) of the barrel (1), a tip member (2) mounted around the sealing member (5) on the medical liquid discharge port (11) of the barrel (1), a closing member (4), a cap member (3), and a holding member (6); the sealing member (5) having a through-hole (51) formed in the axial direction; the tip member (2) including a skirt (24) provided with an engagement pawl (25) on the inner wall of a lower end thereof, a top wall (23), a needle mounting portion (21), and a medical liquid deriving portion (22), and being provided with a medical liquid passage (28); the closing member (4) being inserted into the medical liquid passage (28) and the through-hole (51) to close the through-hole (51) and so prevent oxygen contamination and deterioration of the medical liquid.