Patent SG-11201910173Y-A (SG)
Title: Device and method for microfluidics-based 3d bioprinting
IPC: A61L27/00
Filed: 2018-03-29
Abstract: A) lP ftioshattr . trRRA: : : Mifferent cell types :. n: celE culture mttia Region for mixing of peptide and cells Region for mixing of phosphate buffer solution to induce gelation of the peptide ..\"\" • Peptide hydrogei thread coming out from the nozzle and ready for bioprinting (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ~~~~~ 11111111011101010VIIIOH olo oitimmoimilmnio oimIE (10) International Publication Number WO 2018/207037 Al (51) International Patent Classification: C12M 1/26 (2006.01) B33Y 70/00 (2015.01) A61L 27/00 (2006.01) B33Y 30/00 (2015.01) (21) International Application Number: PCT/IB2018/052189 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,959 11 May 2017 (11.05.2017) US (71) Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY [SA/SA]; 4700 King Abdullah University of Science and Technology, Thuwal, 23955-6900 (SA). (72) Inventors: HAUSER, Charlotte A.E.; King Abdullah University of Science and Technology, Division of Biolog- ical & Environmental Science & Engineering, Laborato- ry for Nanomedicine, Al-Haytham Building (Bldg. 2), Of- fice 4217, Thuwal, 23955-6900 (SA). RAUF, Sakandar; King Abdullah University of Science and Technology, Di- vision of Biological & Environmental Science & Engineer- ing, Laboratory for Nanomedicine, Al-Haytham Building (Bldg. 2), Office 4217, Thuwal, 23955-6900 (SA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE = (54) Title: DEVICE AND METHOD FOR MICROFLUIDICS-BASED 3D BIOPRINTING Figure 1 A (57) : The present invention relates to a device and a method for building a 3D object by mixing a bioink solution, a buffer el solution capable of inducing gelation of the bioink solution and a dispersion containing micro and/or nanoparticles, and ejecting the 0 formed hydrogel out of a nozzle. The present invention further relates to a method of obtaining a hydrogel.