baber/WOPTO huggingface dataset:
Patent NZ-582713-A (NZ)
Title: Liposomes enclosing a radionuclide and a cytotoxic agent for combination therapy
Inventor: LARSEN ROY
IPC: A61K47/48
Filed: 2005-10-21
Abstract: Provided is a cytotoxic agent comprising liposomes wherein said liposomes enclose a solution comprising at least one direct alpha emitting radionuclide selected from 211At, 212Bi, 213Bi, 223Ra, 224Ra, 225Ac and 227Th, or the indirect alpha-emitter 212Pb, and at least one other therapeutic agent, wherein said therapeutic agent is a chemotherapeutic agent. The compositions can be used in medicaments for treating hyperplastic or neoplastic diseases.
Patent NZ-583072-A (NZ)
Title: Shoe insole for arthritic or diabetic patients with a foot shaped bottom layer a rubber middle layer and a fabric upper layer
Inventor: SULAK DUANE M
IPC: A43B1/00
Filed: 2008-11-21
Abstract: Disclosed is an insole especially advantageous for arthritic or diabetic patients. The insole comprises three layers and is shaped in a form which provides an arch support (34) and an integral heel receiving area (35). It is made from a generally foot-shaped bottom layer (3) having a length extending from a heel area to a toe area, a top surface and a bottom surface. The bottom surface of the bottom layer preferably further comprises one to three indentations formed integrally therein. Insert layers are secured to each of the indentations. Preferably, the bottom layer is made from Ethylene Vinyl Acetate (EVA) foam. A middle layer (2) having a first and second side is secured to the top surface of the bottom layer adjacent the middle layer's second side. The middle layer is preferably made of a synthetic rubber layer. The middle layer takes the shape of the bottom layer. A top layer (1) is coextensive with and secured to the first side of the synthetic rubber layer. The top layer composition is selected according to the intended use. In use, the foot of the wearer, with or without a sock or stocking thereon, rests upon the top layer in the foot-receiving compartment of the shoe.
Patent NZ-584385-A (NZ)
Title: Ststem and method for protection of scr catalyst and control of multiple emissions
Inventor: GADGILL MANDAR R
IPC: B01D53/64
Filed: 2010-03-31
Abstract: A method for increasing the active life of an SCR catalyst is disclosed, wherein the method comprising the steps of: (a) providing at least one iron-bearing compound to a combustion zone or flue gas stream of a furnace, or boiler, prior to entry of the flue gas into an SCR system; and (b) permitting the at least one iron-bearing compound to react with any gaseous phosphorus compounds, or phosphorus-containing compounds, present in the combustion zone or flue gas prior to the entry of the flue gas into the SCR system. Preferably the iron-bearing compound is selected from one or more iron (II) halides, iron (Ill) halides, iron (Ill) iodate, iron (III) oxide, iron (II) carbonate, or mixtures of two or more thereof. The disclosure also relates to a method for sequestering one or more phosphorus compounds, or phosphorus-containing compounds, in the form of one or more less reactive iron-phosphorus-containing compounds, the method comprising the steps of: (A) providing at least one iron-bearing compound to a combustion zone or flue gas stream of a furnace, or boiler; and (B) permitting the at least one iron-bearing compound to react with any gaseous phosphorus compounds, or phosphorus-containing compounds, present in the combustion zone or flue gas to form one or more less reactive iron-phosphorus-containing compounds.
Patent NZ-585001-A (NZ)
Title: Antisense modulation of insulin-like growth factor binding protein 5 expression
Inventor: FREIER SUSAN M
IPC: A61K38/00
Filed: 2002-10-07
Abstract: Provided is an antisense oligonucleotide 8 to 50 nucleobases in length targeted to nucleobases 197 through 216 of a nucleic acid molecule (SEQ ID NO: 12) encoding insulin-like growth factor binding protein, wherein said oligonucleotide specifically hybridizes with one of said regions and inhibits the expression of insulin-like growth factor binding protein 5 when the antisense molecule has at least a 70% complementary sequence to the said targeted nucleobases. The antisense oligonucleotide can be used to treat diseases responsive to inhibition of insulin-like growth factor binding protein 5, including various cancers.
Patent NZ-587416-A (NZ)
Title: Two part line stripper, with one on either side of the line and with each part having elements of a line guide, a stripping element and a material guide
Inventor: GEORGE NIGEL HAMISH
IPC: A01G17/02
Filed: 2010-08-17
Abstract: 587416 A apparatus 20 for use in stripping irregular material from a line 3,4 during relative movement between the apparatus 20 and line 3,4 , the apparatus 20 including a material guide, stripping mechanism and line guide, the material guide being configured to guide the irregular material on the line 3,4 into engagement with the stripping mechanism during the relative movement, the material guide including first and second driven material guide elements 50a, 50b respectively rotatable about first and second material guide rotation axes, the stripping mechanism including first and second driven stripping elements respectively rotatable about first and second stripping element rotation axes, and the line guide including first and second line guide elements 30a, 30b. The first line guide element 30a, first stripping element 41a and first material guide element 50a collectively form a first stripping assembly and the second line guide element 30b, second stripping element 41b and second material guide element 50b collectively form a second stripping assembly. The line 3, 4 pass between the stripping assemblies during the stripping. The stripping assemblies are orientated during the stripping such that the first material guide rotation axis, first line guide element 30a and the first stripping element rotation axis are on a first lateral side of the line 3, 4 and the second material guide rotation axis, second line guide element 30b and the second stripping element rotation axis are on a second lateral side of the line 3, 4.
Patent NZ-587693-A (NZ)
Title: Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
Inventor: TRAN THUY-ANH
IPC: A61K31/17
Filed: 2009-03-17
Abstract: The disclosure relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. These compounds are useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Patent NZ-589627-A (NZ)
Title: Pharmaceutical compositions comprising an opioid and a 4-(2-furanyl)thiazole compound for suppressing undesirable effects of opioids
Inventor: OUCHI JUN
IPC: C07D417/14
Filed: 2009-05-29
Abstract: Disclosed are pharmaceutical compositions comprising: (i) a furan-containing or thiazole-containing compound of formulae (I) to (VIII) or salt thereof, having adenosine A2A receptor antagonistic activity and (ii) an opioid. Also disclosed is the use of compounds of formulae (I) to (VIII) to reduce the side-effects of opioids such as analgesic tolerance, hyperalgesia, constipation, dependence and drowsiness. Suitable opioids include anileridine, opium, ampromide, allylprodine, alphaprodine, alfentanil, isomethadone, ethylmethylthiambutene, ethylmorphine, ethoheptazine, etonitazene, eptazocine, endorphin, enkephalin, oxycodone, oxymorphone, clonitazene, ketobemidone, cocaine, codeine, cylmorphan, diamorphone, dioxaphetylbutyrate, didezocine, dinorphine, dihydrocodeine, dihydromorphine, dipipanone, dimethylthiambutene, dimenoxadol, dimepheptanol, sufentanil, tilidine, dextromoramide, desomorphine, tramadol, narceine, nalorphine, nalbuphene, nicomorphine, norlevorphanol, normethadone, normorphine, norpipanone, papaveretum, hydrocodone, hydroxypethidine, hydromorphone, piminodine, piritramide, fentanyl, phenazocine, phenadoxone, phenoperidine, phenomorphan, butorphanol, buprenorphine, properidine, propoxyphene, propheptazine, promedol, heroin, bezitramide, berzylmorphine, pentazocine, myrophine, methadone, metazocine, metopon, meptazinol, meperidine, morphine, levallorphan, levophenalofentanil, levorphanol, and remifentanil.
Patent NZ-592748-A (NZ)
Title: 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators
Inventor: GILL GURMIT S
IPC: C07C225/16
Filed: 2009-10-19
Abstract: Disclosed are 2-amino-(oxadiazol-3-yl)-benzofuran derivatives as represented by the general formula (I), wherein each of the dotted lines ---- independently is a bond or absent; a, b and c are independently selected from C, O, N and S to provide a five membered heterocyclic ring, G represents an amine containing organic substituent; A represents one or more ring atoms selected from C and N; X is a monocyclic or bicyclic aryl or heteroaryl ring; and wherein J, m and D separately, or in any combination, are selected from hydrogen, deuterium, alkoxy, alkylamino, halogen, amino, hydroxy, oxo (=O), imino (=NR), cyano, aryl, heterocycle, carbocycle, or an alkyl chain said alkyl chain optionally containing carbon-carbon multiple bond, carbon-hetero atom multiple bond and wherein one or more carbon atoms of said alkyl chain can be independently replaced with oxygen, sulphur, SO, SO2, NR' (wherein R' is selected from alkyl, cycloalkyl, aryl, heterocycle), carbocycle and heterocycle; or J, m and D are linked together to form a ring with X; or the group m is a substituent attached to either one of J or D. Representative compounds include 2-amino-2-(5-(5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol, 2-amino-2-(5-(5-(4-bromo-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol, 2-amino-2-(5-(5-(3-chloro-4-(thiophen-3-yl)phenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol, 2-amino-2-(6-chloro-5-(5-(4-propylphenyl)-1,2,4-oxad iazol-3-yl)benzofuran-2-yl)propane-1,3-diol and 5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-propoxybenzonitrile. Further disclosed is a pharmaceutical preparation, which comprises at least one compound as defined above in any of its stereoisomeric and/or isotopic forms and/or physiologically tolerable and/or therapeutically effective salts or mixtures thereof in any ratio together with a pharmaceutically acceptable carrier( s) or excipient( s), for the treatment and/or immunotherapy of cancer, solid tumours, haematological disorders, infections, immunological and immune mediated disorders, pain, vascular, cardiovascular, liver disease/injury, lung pathologies/injury, hypoxia and/or allograft or autograft rejection.
Patent NZ-594453-A (NZ)
Title: Phosphate surfactants
Inventor: PENG SHENG
IPC: C09K23/00
Filed: 2010-03-18
Abstract: Abstract 594453 Disclosed is a compound of Formula 1 Rf A-OP(O)(O-M+(OROH) Formula 1 wherein Rf is a C2 to C6 linear or branched perfluoroalkyl optionally interrupted by one, two or three ether oxygen atoms; A is (CH2CF2)m(CH2)n-, (CH2)OSO2N(CH3)(CH2)p-, 0(CF2)q(CH2)r-, or OCHFCF2OE-; m is O to 4; n, o, p, and r are each independently 2 to 20; q is 2; E is a C2 to C20 linear or branched alkyl group optionally interrupted by oxygen, sulfur, or nitrogen atoms; a cyclic alkyl group, or a C6 to C10 aryl group; M is H or a Group I metal or an ammonium cation (NHxR2y)+ wherein R2 is a C1 to C4 alkyl, x is O to 4, y is O to 4 and x + y is 4; and R is a C2 to C60 linear or branched alkyl group optionally interrupted by hetero atoms selected from the group consisting of an oxygen, sulfur, or nitrogen atom; a cyclic alkyl; or a C6 to C10 aryl; provided that when R is greater than 8 carbons, the ratio of hetero atoms to carbon atoms is at least 1:2.Disclosed uses for such compounds includes: a coating composition, latex, polymer, floor finish, ink, emulsifying agent, foaming agent, release agent, repellency agent, flow modifier, film evaporation inhibitor, wetting agent, penetrating agent, cleaner, grinding agent, electroplating agent, corrosion inhibitor, etchant solution, soldering agent, dispersion aid, microbial agent, pulping aid, rinsing aid, polishing agent, personal care composition, drying agent, antistatic agent, bonding agent, acid, base, or brine.
Patent NZ-602898-A (NZ)
Title: Electrochemical cell stack
Inventor: MARCHAL FREDERIC ANDRE
IPC: H01M8/24
Filed: 2011-04-18
Abstract: 602898 A cell stack is disclosed comprising an electrochemical cell, or a plurality of axially arranged cells, with an end plate (5) at each end of the stack. Each cell comprises an active area surrounded by a peripheral area. The active area comprises the membrane electrode assembly, and the peripheral area includes one or more channels for the reactants. The stack comprises means (6) for applying pressure axially to the active area and separate means (1) for applying pressure axially to the peripheral area. The arrangement provides a more consistent, adjustable pressure to the active area while maintaining pressure on the peripheral area. Maintenance and disassembly of the stack is also simplified.
Patent NZ-608256-A (NZ)
Title: A structure for preventing rockfall, a rockfall prevention method, and a method for designing said structure
Inventor: NOMURA TOSHIMITSU
IPC: E01F7/04
Filed: 2009-02-27
Abstract: A rock fall prevention method is disclosed capable of preventing the collapse of a surface layer and preventing the falling of identified rock masses (22). The slope is covered with a net assembly (2) constructed of rope materials (3) and anchored into slope using anchors (6). The anchors (6) are inserted into slope to stabilize a surface layer, giving the anchors (6) and the net assembly (2) enough strength to suppress the movement of identified rock masses (22). The spacing and selection of the anchors (6) is determined based on slope and geology data for blocks in a grid defined by the positioning of the anchors (6).
Patent NZ-610206-A (NZ)
Title: Method for securing a surface material to a substrate material
Inventor: GONG YONGPING
IPC: F16B25/10
Filed: 2008-11-25
Abstract: A method of securing a surface material (20) to a substrate (30) using a threaded screw fastener is disclosed. The faster has a point (5), a shank (4) and a head (2). The shank comprises an unthreaded linear travel area (6) adjacent to the point and a double lead threaded area) between the linear travel area (6) and the head (2). The threaded area comprises a first threaded portion (7) extending from the head (2) towards the point and a second threaded portion (8) between the first threaded portion (7) and the unthreaded linear travel area (6). The thread height in the second threaded portion (8) is less than in the first threaded portion (7). The fastener is non-rotatably driven into the surface (20) and substrate (30) (B) and then rotatably driven so that the threaded area engages the substrate (30) (C) until the head (2) is about flush with the surface (D).
Patent NZ-614347-A (NZ)
Title: Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2-6-dione in treatment of immune-related and inflammatory diseases
Inventor: GANDHI ANITA
IPC: C07D239/88
Filed: 2012-03-09
Abstract: Disclosed herein are methods of using 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (compound 1) for modulating lymphocytic activity, including activity of B cells and/or T cells, and in immune-related diseases or inflammatory diseases, including systemic lupus erythematosus and scleroderma. Disclosed are pharmaceutical compositions and dosing regimens for use in the methods provided.
Patent NZ-618893-A (NZ)
Title: Fiber termination enclosure with modular plate assemblies
Inventor: COAN JONATHAN WALTER
IPC: G02B6/46
Filed: 2012-06-22
Abstract: Disclosed is an optical fibre termination enclosure system. The enclosure housing includes a top wall, a bottom wall, a first side wall, a second side wall, and a rear wall defining an interior having an open front with a door for selectively covering the open front. The enclosure includes a plurality of modular plate assemblies that are each configured to be selectively mounted within the interior of the enclosure housing. Each modular plate assembly includes a mounting plate that is configured to be coupled to the rear wall of the enclosure housing. The plurality of modular plate assemblies includes: a termination panel plate assembly including a plurality of termination adapters coupled to the respective mounting plate; a splice tray plate assembly including at least one splice tray disposed on the respective mounting plate; a cable spool plate assembly including a cable spool disposed on the respective mounting plate, the cable spool being configured to rotate relative to the enclosure housing; and a drop-in plate assembly including at least one termination adapter disposed on a horizontally extending drop-in plate disposed on the respective mounting plate.
Patent NZ-620177-A (NZ)
Title: Novel fxr (nr1h4) binding and activity modulating compounds
Inventor: KINZEL OLAF
IPC: C07D413/14
Filed: 2012-07-12
Abstract: Disclosed herein are compounds of formula 1 where the substituents are as defined herein. The compounds have activity as FXR binding and activity modulating compounds and are therefore intended for use in the treatment of conditions such as liver diseases, inflammatory bowel diseases, diabetes, obesity, myocardial infarction, stroke and hyperproliferative disorders.
Patent NZ-624819-A (NZ)
Title: Acc inhibitors and uses thereof
Inventor: HARRIMAN GERALDINE C
IPC: C07D495/04
Filed: 2012-11-09
Abstract: The present disclosure provides compounds, specifically thienopyrimidine derivatives, useful as inhibitors of Acetyl CoA Carboxylase (ACC), pharmaceutical compositions thereof, and methods of using the same for treating ACC-mediated disorders such as obesity, dyslipidemia, hyperiipidemia, fungal, parasitic or bacterial infections in a subject. The disclosure further provides a method of inhibiting ACC in a plant comprising contacting the plant with the inhibitor compound.
Patent NZ-702749-A (NZ)
Title: Neprilysin inhibitors
Inventor: FLEURY MELISSA
IPC: C07D405/12
Filed: 2013-06-06
Abstract: In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Patent NZ-709235-A (NZ)
Title: Compounds and their use as bace inhibitors
Inventor: CSJERNYIK GABOR
IPC: C07D401/04
Filed: 2011-12-21
Abstract: Disclosed is a process for the synthesis of lanabecestat ((1r,1’R,4R)-4-methoxy-5’’-methyl-6’-(5-prop-1-yn-1-ylpyridin-3-yl)-3’H-dispiro[cyclohexane-1,2’-indene-1’,2’’-imidazol]-4’’-amine), or a pharmaceutically acceptable salt thereof, wherein the process comprises a Suzuki coupling reaction of 5-(prop-1-ynyl)pyridin-3-ylboronic acid with (1r,4r)-6’-bromo-4-methoxy-5’’-methyl-3’H-dispiro[cyclohexane-1,2’-indene-1’,2’’-imidazol]-4’’-amine, in the presence of a transition metal catalyst such as [1,1’-bis(diphenylphosphino)ferrocene]palladium(II) chloride or sodium tetrachloropalladate (II), and a base (e.g. potassium carbonate). The process can also be extended to utilise as starting materials compounds including (1r,4r)-6’-bromo-4-methoxy-5’’-methyl-3’H-dispiro[cyclohexane-1,2’-indene-1’,2’’-imidazole]-4’’(3’’H)-thione, (1r,4r)-6’-bromo-4-methoxyspiro[cyclohexane-1,2’-inden]-1’(3’H)-imine hydrochloride, 2-oxopropanethioamide, N-((1r,4r)-5’-bromo-4-methoxyspiro[cyclohexane-1,2’-indene]-3’(1’H)-ylidene)-2-methylpropane-2-sulfinamide, (1r,4r)-6’-bromo-4-methoxyspiro[cyclohexane-1,2’-inden]-1’(3’H)-one, (1r,4r)-6’-bromo-4-hydroxyspiro[cyclohexane-1,2’-5 inden]-1’(3’H)-one, 6’-bromospiro[cyclohexane-1,2’-indene]-1’,4(3’H)-dione and 6-bromo-2,3-dihydro-1H-inden-1-one.
Patent NZ-713404-A (NZ)
Title: Rotor blade of a wind turbine
Inventor: PAWIS TORSTEN
IPC: F03D1/06
Filed: 2014-04-09
Abstract: During operation, rotor blades of wind turbines are exposed to the wind and weather conditions which may result in ice depositing on the rotor blade. Such ice deposits affect the optimum operation of the rotor blade and therefore wind turbine. In order to address this problem, the present invention relates to a rotor blade of a wind turbine, having - a rotor blade nose, - a rotor blade rear edge, - a rotor blade root region for attaching the rotor blade to a hub of the wind turbine, - a rotor blade tip, - wherein the rotor blade extends from the rotor blade root region along a longitudinal direction to the rotor blade tip and - the rotor blade internally comprises at least - a first cavity adjacent the blade nose and - a second cavity adjacent the rotor blade rear edge, and - the first cavity is heated by a first heating means and the second cavity is heated by a second heating means, in order to heat the rotor blade nose or the rotor blade rear edge respectively.
Patent NZ-717449-A (NZ)
Title: Antimicrobial compositions
Inventor: LEIBOWITZ SARAH
IPC: A61K31/19
Filed: 2014-10-22
Abstract: Antimicrobial compositions and related methods are disclosed. The antimicrobial compositions include glycolic acid, an anionic surfactant, and at least one additional surfactant selected from anionic and nonionic surfactants. The antimicrobial compositions may be formulated as a teat dip for controlling or preventing bovine mastitis.
Patent NZ-720482-A (NZ)
Title: Methods of microbiological control in beet sugar and other sugar-containing plant material processing
Inventor: VAN HAUTE EDDIE
IPC: A01N33/14
Filed: 2014-12-02
Abstract: Methods are described for producing sugar from sugar-containing plant material with microbiological control, which includes treating a sugar-containing plant raw material and/or a component derived therefrom, and/or a medium containing the plant raw material and/or the component, with monochloramine. Monochloramine usage in the method can reduce loss of sugar from bacterial consumptions in the processing of sugar-containing plant materials, such as sugar beets, without causing adverse effects on the sugar product, such as the brightness of white sugar.