baber/WOPTO huggingface dataset:
Patent EP-4210761-A1 (EP)
Title: Conjugué de saponine à base de semicarbazone
Inventor: HERMANS GUY
IPC: A61K47/54
Filed: 2021-09-09
Abstract: L'invention concerne un dérivé de saponine à base d'une saponine comprenant un aglycone de triterpène et au moins l'une d'une première chaîne de saccharide et d'une seconde chaîne de saccharide liées à la structure de noyau d'aglycone, le dérivé de saponine comprenant une structure de noyau d'aglycone comprenant un groupe fonctionnel aldéhyde qui a été transformé en un groupe fonctionnel de semicarbazone. L'invention concerne également une première composition pharmaceutique comprenant le dérivé de saponine selon l'invention. De plus, l'invention concerne une combinaison pharmaceutique comprenant la première composition pharmaceutique selon l'invention et une seconde composition pharmaceutique comprenant par exemple un ADC ou un conjugué GalNAc-oligonucléotide. L'invention concerne également la première composition pharmaceutique ou la combinaison pharmaceutique selon l'invention, pour une utilisation en tant que médicament, ou une utilisation dans le traitement ou la prophylaxie d'un cancer ou d'une maladie auto-immune, d'une maladie cardiovasculaire ou de l'hypercholestérolémie, ou dans un procédé pour abaisser le cholestérol LDL dans la circulation d'un sujet. L'invention concerne également un conjugué de saponine comprenant une molécule protéique, capable de se lier à une cellule, et comprenant éventuellement une fraction effectrice telle qu'un oligonucléotide. L'invention concerne également un conjugué de saponine comprenant GalNAc et un oligonucléotide.
Patent EP-4144277-A1 (EP)
Title: Method and apparatus for controlling dishwasher
Inventor: HUANG LONGZHONG
IPC: A47L15/00
Filed: 2021-04-22
Abstract: Disclosed is a method for controlling a dishwasher, the method comprising: triggering a water-softening apparatus to be in a softening working state during a water intake stage of a working stage during which soft water is needed for washing, so as to introduce water produced when the water-softening apparatus is in the softening working state into a washing cavity of a dishwasher; and after the water-softening apparatus is in the softening working state during the working stage, if at least one of the number of instances and duration of the water-softening apparatus being in the softening working state and the amount of water produced by the water-softening apparatus in the softening working state reaches a corresponding preset value, the water-softening apparatus being in a recycling working state before the water intake stage of the next working stage during which the soft water is needed for washing. The water-softening apparatus comprises several first electrodes and several second electrodes, which are arranged in a stacked manner, wherein the first electrodes and the second electrodes are arranged alternately, and the polarities thereof are opposite. A water flow channel is formed between the first electrode and the second electrode adjacent thereto, wherein the side of one of the two electrodes that faces the channel is provided with an adsorption layer which is used for adsorbing target cations. The water-softening apparatus implements the switching of a softening function and a recycling function by means of converting the polarity of the first electrode and the polarity of the second electrode.
Patent EP-4231882-A1 (EP)
Title: Getränkezubereitungsmaschine mit einem silikonabtropfgitter
Inventor: ERDWIENS ALEXANDER
IPC: A47J31/44
Filed: 2021-10-20
Abstract: Die Erfindung betrifft eine Getränkezubereitungsmaschine (1), die einen Auslauf (14) zur Abgabe eines zubereiteten Getränkes, einen Aufnahmebereich (15) zur Aufnahme eines Gefässes zur Aufnahme des zubereiteten Getränkes, sowie ein Abstellelement (21), das den Aufnahmebereich (15) in die dem Auslauf (14) gegenüberliegende Seite begrenzt und auf dem das Gefäss während der Getränkezubereitung abstellbar ist, umfasst. Das Abstellelement (21) ist zumindest teilweise aus einem Elastomer gefertigt.
Patent EP-4217817-A1 (EP)
Inventor: MANIYAR SHYAMSUNDAR N
IPC: G06F/
Filed: 2021-09-21
Abstract: In one embodiment, dynamic user private networks are virtually segmented within a shared virtual network. A network control system maintains the dynamic logical segmentation of the shared virtual network. User entities (e.g., user devices and/or services) are communicatively coupled to respective personal virtual networks via endpoints of access devices. Each of these endpoints is associated with a corresponding user private network. Responsive in real-time to automated processing of a received electronic particular user request, the network control system automatically modifies the dynamic logical segmentation of the shared virtual network to move a particular user entity on the shared virtual network to newly being on the first dynamic user private network without being disconnected from the shared virtual network. One embodiment uses different user private network identifiers (UPN-IDs) associated with endpoints and received packets to identify their respective user private network.
Patent EP-4146422-A1 (EP)
Inventor: MANCUSO DOMINICK
IPC: B23B31/00
Filed: 2021-04-30
Abstract: A coupling mechanism for securing a tool to a tool arm may include a housing and an engaging lock. The engaging lock may be arranged within the housing and configured for rotation by the tool arm. Rotation of the engaging lock may drive locking mechanisms partially through the housing to establish a longitudinally secured connection.
Patent EP-4221585-A1 (EP)
Inventor: BENNETT NATHAN H
IPC: A61B5/06
Filed: 2021-09-29
Abstract: At least some aspects of the present disclosure is directed to a system for processing cardiac information. The system comprises a processing unit configured to: receive an activation waveform comprising a set of activation waveform data of a plurality of signal sections collected at a plurality of locations; receive a range of window size. The processing unit is further configured to: for each signal section of the plurality of signal sections, determine a set of confidence values, each confidence value corresponding to a window size, by iterating through a plurality of window sizes in the range of window size. The processing unit is further configured to determine one of a plurality of local cycle lengths for the each of the plurality of signal sections based on the selected window size and generate a local cycle length histogram based on the plurality of local cycle lengths.
Patent EP-4240194-A1 (EP)
Inventor: KUSHNIROV AVRAM
IPC: A42B3/04
Filed: 2021-11-04
Abstract: A fastening device 100 for releasably fastening a functional unit 102 in a connection direction to a receiving unit 104. Said functional unit 102 and said receiving unit 104 each have a longitudinal direction L, a transverse direction T and a height direction H. Said fastening device 100 comprises at least one pair of magnets 110, at least one functional unit magnet 112 being allocated at or close to a functional unit abutment surface 106, and at least one receiving unit magnet 114 being allocated at or close to a receiving unit abutment surface 108. Said magnets 112, 114 of said at least one pair of magnets 110 exert an attractive force to each other. According to further aspects, a combination of such a fastening device 100 with a functional unit 102 and a receiving unit 104, as well as a combination of a head protective gear and a fastening unit 100 according are provided.
Patent EP-4150053-A1 (EP)
Inventor: ALLEN-HOFFMANN B LYNN
IPC: C12N5/071
Filed: 2021-05-13
Abstract: The present disclosure is directed to viable bioengineered skin constructs.
Patent EP-4229835-A1 (EP)
Inventor: MAYFIELD ROSS DOUGLAS
IPC: H04L12/18
Filed: 2021-10-07
Abstract: System and methods for recording conference application activity associated with a network conference. In an embodiment, a method is provided for recording conference application activity associated with a network conference. The method includes activating a client application, activating a recording of conference application activity, selecting a conference application from a plurality of conference applications, and running the conference application from the client application. The conference application is run during at least one of before, during, and after a network conference so that conference application activity is recorded. The method also includes exiting the network conference, and completing the recording of the conference application activity.
Patent EP-4159092-A1 (EP)
Inventor: TSURUMI KAZUHIRO
IPC: B60N2/68
Filed: 2021-05-26
Abstract: This cushion support member 110 comprises, apparent on the surface of a junction 120, a first junction line 201 indicating a junction location between a first reinforcement part 121 and a second reinforcement part 122, and a second junction line 202 indicating a junction location between the second reinforcement part 122 and a third reinforcement part 123. The first junction line 201 and the second junction line 202 are each constituted by a curved line, curving in the thickness direction of the cushion support member 110 from one side to the other side thereof. One end of the first junction line 201 and one end of the second junction line 202 meet at the same position 200 on the one side in the thickness direction. This vehicle seat S1 is in a state of being fixed to a base plate 10 via a hook part 16 which has been passed through and hooked to a hole 23, and a fixing material 25 which has been driven, through an end part 21, into the base plate 10. The hook 16 and the fixing material 25 are disposed so as not to overlap in the direction in which the end part 21 from a covering material 20 is pulled.
Patent EP-4157248-A1 (EP)
Inventor: REDDY PREMKUMAR
IPC: A61K31/18
Filed: 2021-05-28
Abstract: Provided herein are methods for treating a virus (e.g,. an RNA virus, such as a SARS-CoV-2) infection or a disease associated therewith (e.g., COVID-19) comprising administering Rigosertib or a composition thereof to a subject (e.g., a human subject).
Patent EP-4249125-A1 (EP)
Inventor: LEE CHANG MIN
IPC: B03C3/74
Filed: 2021-11-12
Abstract: The present invention relates to an air purifier, and more specifically, to an air purifier that is capable of removing hazardous substances and viruses from air. According to the present invention, the air purifier includes: a body having an air inlet formed on a lower end thereof, an air outlet formed on an upper end thereof, and a flow path formed therein to move air upward; a pre-filter disposed in the flow path of the body; a box-shaped cell type discharge device disposed in the flow path of the body to generate active species; a dust collection device in the flow path of the body and having a discharge part with a linear discharge electrode and a dust collection part for collecting the dust charged through the discharge part; an ozone removal device in the flow path of the body to remove ozone generated from the discharge device and/or the dust collection device; and an air fan disposed in the flow path of the body.
Patent EP-4175855-A1 (EP)
Title: Appareil pour véhicule
Inventor: PRAAT CHRISTOPHER WALKER
IPC: B60R9/06
Filed: 2021-11-12
Abstract: L'invention concerne un appareil (2) pour un véhicule (1), l'appareil comprenant un coffre de toit (10) destiné à s'adapter à un toit du véhicule avec une longueur du coffre de toit orientée parallèlement à une longueur du véhicule et un coffre arrière (20) destiné à s'adapter à une partie arrière du véhicule avec une hauteur du coffre arrière orientée parallèlement à une hauteur du véhicule. Le coffre de toit et le coffre arrière butent de préférence l'un contre l'autre le long d'une interface de liaison (25) qui s'étend vers l'arrière et vers le haut à partir d'un fond du coffre de toit.
Patent EP-4256288-A1 (EP)
Inventor: OTTER GERARD CHRISTIAAN JURJEN
IPC: G01J1/42
Filed: 2021-12-06
Abstract: A method and device (10) for making a calibrated measurement of light from an object (E). In a first measurement window (W1), object light (L E ) is received from the object (E) onto a beam splitter (11) which splits the light into a signal path (Ps) and a reference path (Pr). A first signal (S1=T⋅L E ⋅Hs) is measured by a signal detection element (15s) in the signal path (Ps). A second signal (S2=R⋅L E ⋅Hr) is measured by a reference detection element (15r) in the reference path (Pr). In a second measurement window (W2), calibration light (L C ) is received onto the beam splitter (11). A third signal (S3=R⋅L C ⋅Hs) is measured by the signal detection element (15s) in the signal path (Ps). A fourth signal (S4=T⋅L C ⋅Hr) is measured by the reference detection element (15r) in the reference path (Pr). A measurement value of the object light (L E ) is determined based on the measured signals (S1,S2,S3,S4).
Patent EP-4251814-A1 (EP)
Inventor: HARTWELL ERIK KARL
IPC: E03F5/14
Filed: 2021-11-12
Abstract: The embodiments of the present disclosure provide a system for removing particulates from liquid. The system may comprise a base 210, a tubular body 480 extending upwardly from the base, a liquid quality device 100 located above the base, a sump region 240 located between the base and the liquid quality device, and a plurality of drag-inducing portions 450 positioned in the sump region and projecting inwardly toward a central axis of the sump region. The tubular body may comprise an inlet and an outlet. The plurality of drag-inducing portions may comprise a first set of drag-inducing portions 450a, a second set of drag-inducing portions 450b, a third set of drag-inducing portions 450c, and a fourth set of drag-inducing portions. The first, second, third, and fourth sets of drag-inducing portions may be positioned equidistant from each other and at a same height around a perimeter of the sump region.
Patent EP-4167995-A1 (EP)
Inventor: CHEN JAMES KENNETH
IPC: A61K31/41
Filed: 2021-06-16
Abstract: Compounds and methods are provided for inhibiting an aldehyde dehydrogenase (ALDH). Methods of treating cancer are also provided. The ALDH-inhibitor can be a compound that is based on a cyclic guanidine, or an imidazolium core. In certain embodiments, the ALDH-inhibitor compound is a substituted cyclic guanidine, or a substituted imidazolium compound. Aspects of the methods include methods of selectively inhibiting a particular ALDH family member. In some cases, the subject compounds are ALDH1 B1-selective inhibitors. In some cases, the subject compounds are ALDH1A3-selective inhibitors.
Patent EP-4053908-A1 (EP)
Inventor: LIU CONG
IPC: H01L27/32
Filed: 2021-05-18
Abstract: A display substrate and a display device. The display substrate (1) comprises a first side (S1) for display and a second side (S2), and comprises: a base substrate (100); a display region comprising a first display region (10) and a second display region (20), the first display region (10) comprising multiple pixel unit groups (PI), each of the multiple pixel unit groups (P1) comprising multiple first pixel units (P0), and each of the multiple first pixel units (P0) comprising a pixel region (A11) and an aperture region (A12); multiple first power supply lines (VDD1) located in the pixel region (A11); and a shielding layer (LS) comprising a hollowed-out region (LS2) and a shielding region (LS1). For each of the pixel unit groups (PI), the aperture region (A12) of each of the first pixel units (P0) and the shielding region (LS1) of the shielding layer at least partially overlap. The aperture region (A12) of at least one of the first pixel units (P0) comprises a first shield connection portion (SP1) at least partially overlapping with the shielding region (LS1) of the shielding layer (LS). The shielding layer (LS) is connected to at least one of the first power supply lines (VDD1) by means of the first shield connection portion (SP1). The display substrate connects the shielding layer to a direct current signal without reducing the pixel density, and prevents the shielding layer from being in a floating state.
Patent EP-4176893-A1 (EP)
Title: Construction and application of fusion protein vaccine platform
Inventor: FU YANGXIN
IPC: A61K39/395
Filed: 2021-07-01
Abstract: The present invention relates to the construction and application of a fusion protein vaccine platform. The present invention provides a vaccine, comprising a fusion protein containing an interferon-target antigen-immunoglobulin Fc region (or antibody) and a Th cell helper epitope. The present invention also relates to use of a fusion protein containing an interferon-target antigen-immunoglobulin Fc region (or antibody) and a Th cell helper epitope in the preparation of prophylactic or therapeutic compositions. The vaccine of the present invention can be produced by eukaryotic cell expression systems to prepare wild-type and various mutant antigen vaccines, and vaccination by means of subcutaneous/muscular or nasal or other routes can lead to a strong immune response to a body. The vaccine of the present invention can be used as a prophylactic or therapeutic vaccine.
Patent EP-4176862-A1 (EP)
Inventor: KIM JUN HO
IPC: A61J7/00
Filed: 2021-06-15
Abstract: A medicine information marking device according to an embodiment of the present invention is used in a medicine packaging apparatus which dispenses medicines from a medicine storage unit, in which the medicines are stored, on the basis of a medicine discharging request and then packages the dispensed medicines in a medicine packing paper so that the medicines are divided into single doses and dispensed in one-dose packages, wherein one of multiple information marking parts is selectively pressed and moved so as to mark predetermined information.
Patent EP-4267874-A1 (EP)
Inventor: THOMAS PIERRE-ARMAND
IPC: F16L9/22
Filed: 2021-12-14
Abstract: The invention relates to a device for pumping water from a great depth, comprising a plurality of longitudinal elements (8) assembled together to form a pipe, inside which flows the water pumped from a great depth, wherein each longitudinal element (8) comprises a wall (10), for example of thickness less than or equal to 5 cm, forming a section of the pipe, the wall (10) being prestressed in tension, for example longitudinally and/or circumferentially, when water is not pumped in the pipe.
Patent EP-4084714-A1 (EP)
Title: Electrosurgical instrument system with parasitic energy loss monitor
Inventor: SHELTON IV FREDERICK E
IPC: A61B18/12
Filed: 2021-12-29
Abstract: A method of performing an electrosurgical procedure includes activating an electrode of a surgical instrument by applying an output power signal with a first energy output profile from a generator to the electrode. An induced electrical parameter of a conductive component is monitored via one or more sensors, the induced electrical parameter being associated with a predetermined electrical parameter threshold. The induced electrical parameter includes a parasitic energy loss. When the induced electrical parameter measured from a conductive component of the surgical instrument meets or exceeds the predetermined electrical parameter threshold during the operation, the output power signal of the generator is adjusted from a first energy output profile to a second energy output profile. The adjustment is operable to reduce the induced electrical parameter measured from the conductive component of the surgical instrument; and to reduce the parasitic energy loss without ceasing delivery of energy to the electrode.
Patent EP-4259146-A1 (EP)
Inventor: EVANGELISTA MARIE
IPC: A61K31/506
Filed: 2021-12-06
Abstract: L'invention concerne des polythérapies comprenant un inhibiteur de KRasG12C (par exemple le composé 1) et un inhibiteur d'EGFR et des méthodes d'utilisation de telles polythérapies.
Patent EP-4259916-A1 (EP)
Inventor: DE CARNÉ-CARNAVALET VINCENT MARIE JACQUES RÉMI
IPC: F02C7/14
Filed: 2021-12-02
Abstract: The invention relates to a turbine engine (1) extending along an axis (X), comprising a flow path (2) of a primary flow (F1) comprising a compressor, a combustion chamber and a turbine, an outflow region (3) of a secondary flow (F2), surrounding the primary path (2), a blower (6) or a propeller located upstream of the primary path (2) and the outflow region (3) of the secondary flow (F2), at least one arm (7) extending radially through the primary path (2), at least one fluid circulation pipe extending inside the arm (7), characterised in that the arm (7) comprises an inlet for air from the primary path so as to cool the fluid circulating in the pipe.
Patent EP-4255570-A1 (EP)
Title: Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms
Inventor: SIMONS EMMANUEL JOHN
IPC: A61P27/16
Filed: 2021-11-30
Abstract: The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.
Patent EP-4200132-A1 (EP)
Inventor: SCHWARZ RICHARD
IPC: B32B27/36
Filed: 2021-12-10
Abstract: ln an embodiment, the invention comprises a packaging structure comprising a cap layer which comprises post-consumer resin, at least one additional layer adjacent the first layer which comprises an alloy of: polyethylene terephthalate; a polyolefin; and at least one compatibilizer; a barrier coating adjacent the at least one additional layer and opposite the cap layer, wherein the barrier coating comprises a matrix of polyethyleneimine and polyvinyl alcohol and an overlacquer about the barrier coating. The methods of the invention may include co-extruding the cap layer and an alloy layer to form a co-extrudate; optionally, melt adhering the co-extrudate to another alloy layer to form a melt-adhered sheet; intermixing a solution of polyethyleneimine, polyvinyl alcohol, and water to form a coating; applying the coating to the outermost alloy layer opposite the cap layer; drying the applied coating; applying an overlacquer about the coating; and drying the overlacquer.
Patent EP-4267087-A1 (EP)
Title: Composition de maquillage avec tenue de la matité
Inventor: CHAMPREDONDE ELODIE
IPC: A61K8/25
Filed: 2021-12-23
Abstract: La présente invention concerne une composition cosmétique de soin et/ou de maquillage des matières kératiniques, en particulier des lèvres, comprenant, dans un milieu physiologiquement acceptable : a) Un polymère silicone-polyuréthane en une teneur en matière active d'au moins 17,5% en poids par rapport au poids total de la composition, b) Un ou plusieurs alcanes linéaires ou ramifiés en C8-C19, c) Une poudre de silice, de préférence traitée hydrophobe, et d) Eventuellement des pigments.
Patent EP-4197183-A1 (EP)
Inventor: CHEN CHEN
IPC: H04L65/1104
Filed: 2021-02-13
Abstract: Embodiments include systems and methods for wireless device signaling a network regarding customized ringing signal (CRS) capability and use of such information by the network. Various embodiments may receiving from the network an INVITE message notifying the wireless device of an incoming call, determining whether the INVITE message indicates that the network provides CRS service if the wireless device supports a CRS function, and including an indication in a response to the INVITE that the wireless device supports the CRS function in response to determining that the INVITE message includes an alert information header field indicating that the network provides CRS service. Various embodiments include a network computing device receiving such information and performing negotiations for CRS service with the wireless device only if the wireless device indicates CRS functional capability.