Patent SG-11201805423T-A (SG)
Title: Indolinones compounds and their use in the treatment of fibrotic diseases
Inventor: WALTERS IAIN
IPC: C07D413/12
Filed: 2016-12-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1101111 0 11101 HOE HO 11111 0 111 010 1101H Ell 011100111E HOED International Bureau 0.. .... .. (10) International Publication Number ...... ... (43) International Publication Date WO 2017/109513 Al 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: ited, 50-100 Holmers Farm Way, High Wycombe Bucking- CO7D 403/12 (2006.01) A61K 31/497 (2006.01) hamshire HP12 4EG (GB). CO7D 413/12 (2006.01) A61P 11/00 (2006.01) (74) Agents: TEUTEN, Andrew et al.; Three Globeside, Field- C07D 209/34 (2006.01) C07C 205/57 (2006.01) A61K 31/404 (2006.01) house Lane, Marlow, Buckinghamshire SL7 1HZ (GB). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/GB2016/054069 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 23 December 2016 (23.12.2016) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 15202764.5 24 December 2015 (24.12.2015) EP TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: RESPIVERT LIMITED [GB/GB]; 50-100 ZA, ZM, ZW. Holmers Farm Way, High Wycombe Buckinghamshire (84) Designated States (unless otherwise indicated, for every HP12 4EG (GB). kind of regional protection available): ARIPO (BW, GH, (72) Inventors: WALTERS, lain; c/o Sygnature Discovery GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Ltd, Biocity Nottingham, Pennyfoot Street, Nottingham TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Nottinghamshire NG1 1GF (GB). BIRCH, Louise; c/o TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Sygnature Discovery Ltd, Biocity Nottingham, Pennyfoot DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Street, Nottingham Nottinghamshire NG1 1GF (GB). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, HILL-COUSINS, Joseph; c/o Sygnature Discovery Ltd, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Biocity Nottingham, Pennyfoot Street, Nottingham Not- GW, KM, ML, MR, NE, SN, TD, TG). tinghamshire NG1 1GF (GB). COLLINGWOOD, Steph- Published: — _ en, Paul; c/o RespiVert Limited, 50-100 Holmers Farm = with international search report (Art. 21(3)) Way, High Wycombe Buckinghamshire HP12 4EG (GB). — STEVENSON, Christopher, Scott; c/o RespiVert Lim- _ = = = = = Title: INDOLINONES COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES (54) = = Z, R3 (I) = O . 1-1 NH R 1 i M 11 4 11 kf) C:r © 11 IN 1-1 (57) : The present invention relates inter alia to a compound of formula (I) Wherein R I , R 2 , R 3 and Z are as defined in the 0 specification and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in \" treatment, for example in the treatment of fibrotic diseases or interstitial lung diseases, in particular idiopathic pulmonary fibrosis.