baber/WOPTO huggingface dataset:
Patent UY-25573-A1 (UY)
Title: Procedimiento para preparar derivados de 2''-desoxi higromicina a
Inventor: LINDE II ROBERT GERALD
IPC: A61P33/02
Filed: 1999-06-18
Abstract: Esta invención se refiere a derivados de 2"-desoxi higromicina A de fórmula (I), en la que: R1 es H y R2 es -NR3R4, -NR4C(O)R3, -OC(O)NR3R4 u -OR3; o R1 y R2 se toman conjuntamente para formar =O, =N-, -OR3, =CR4R3, =CR4C(O)R3, =CR4C(O)OR3 o =CR4C(O)NR3R4; cada R3 se selecciona independientemente entre H, alquilo, alquenilo, -(CH2)t(cicloalquilo), -(CH2)(arilo) y -(CH2)t(heterociclo), donde t es de 0 a 5; cada R4 es independientemente H o alquilo; y a sales farmacéuticamente aceptables, profármacos y solvatos de los mismos. Dichos compuestos son útiles como agentes antibacterianos y antiprotozoarios en mamíferos, incluyendo el ser humano, así como en peces y aves. Ej. no limitante: 5-desoxi-5-[[3-[4-[(2,6-didesoxi-beta-D-eritro-hexofuranos-5-ulos-1-il)oxi]-3-hidroxifenil]-2-metil-1-oxo-2-(E)-propenil]amino]-1,2-O-metileno-D-neo-inositol, (Z)-O-[(3-fluorofenil)metil]oxima
Patent UY-26079-A1 (UY)
Title: Nuevos derivados de morfolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
Inventor: DUCOUX JEAN PHILIPPE
IPC: C07D265/30
Filed: 2000-03-27
Abstract: La invención se refiere a los compuestos de la fórmula I así como sus sales con ácidos minerales u orgánicos, sus solvatos y/o sus hidratos, que presentan una fuerte afinidad y una gran selectividad para con los receptores NK1 humanos de la Substancia P. La invención se refiere también a su procedimiento de preparación, sus compuestos intermediarios de fórmula (IV), (VI) y (VIII) útiles para su preparación, a las composiciones farmacéuticas que los contienen y a su utilización para la fabricación de medicamentos destinados a tratar cualquier patología donde están implicados la Substancia P y/o los receptores NK1 humanos.
Patent UY-26342-A1 (UY)
Title: Vectores adenovirales recombinantes y su utilidad en el tratamiento de diversos tipos de fibrosis hepática, renal, pulmonar y cicatrices hipertróficas
Inventor: BORUNDA JUAN ARMENDARIZ
Filed: 2000-09-15
Abstract: Se propone el uso de terapia génica para su aplicación en el tratamiento de diversas fibrosis en humanos. El objetivo es la utilización de genes "terapéuticos" específicamente dirigidos a órganos blanco para revertir y/o prevenir el desarrollo del proceso que cursa con fibrosis. La potencial aplicación de terapia génica a pacientes con fibrosis y/o cirrosis dependerá en buena parte del envío exitoso de genes que codifiquen para proteínas terapéuticas a hígados con fibrosis extensa y que estos genes que codifiquen para proteínas MMP-8 latente y activa, MMP-1, MMP-2, MMP-9 y MMP-13; uPA silvestre y/o modificado (o su versión truncada); receptor truncado tipo II de TGF-beta y Smad7 sean dirigidos por adenovirus y/o otros vectores recombinantes que no transduzcan (infecten) otros órganos de la economía. Los adenovirus recombinantes (AdR) son vectores altamente eficientes para la transducción de genes terapéuticos a diversas células blanco. Hemos probado que se pueden llevar genes a hígados cirróticos. El envío de genes terapéuticos mediante dichos vectores adenovirales y otros vectores recombinantes se podrá realizar utilizando liposomas (DOTMA) catiónicos y aniónicos. Asimismo, proponemos el uso de esta patente para que de igual manera sea aplicada a: *Fibrosis renal, *Fibrosis pulmonar, *Cicatrices hipertróficas y keloides (Fibrosis de la piel) y * Otros tipos de fibrosis.
Patent UY-26343-A1 (UY)
Title: Nuevos derivados de benicimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopamina
Inventor: CEREDA ENZO DR
Filed: 2000-09-19
Abstract: El presente invento se refiere a compuestos de la fórmula general (i) en la que R1, R2, R3, R4 significan hidrógeno o hidróxi, con la condición de que R1, R2, R3 y R4 no pueden representar simultáneamente hidrógeno, a procedimientos para su preparación y a su uso como compuestos farmacéuticos.
Patent UY-27443-A1 (UY)
Title: Sales de ácidos salicílicos, procedimientos para su preparación, y su uso como medicamentos
Inventor: LINZ GUENTER
IPC: A61P15/06
Filed: 2002-09-11
Abstract: La presente invención se refriere a nuevas sales de ácidos salicílicos sustituidos y salmeterol, a procedimientos para su preparación, y a su uso como medicamentos.
Patent UY-28666-A1 (UY)
Title: Compuesto medicinal para tratamiento del cancer
Inventor: MORAES JOSE LEONEL CHAVES
IPC: A61P35/00
Filed: 2004-12-10
Abstract: La presente invención provee una composición que comprende una mezcla de tinturas de bacharis trimera, vernonia nudiflora y plántago major útil para el tratamiento del cáncer provee también un procedimiento para su preparación.
Patent UY-29337-A1 (UY)
Title: N-aminometilensulfonamidas sustituidas, su preparación y su uso como medicamentos.
Inventor: PETRY DR STEFAN
IPC: A61K31/095
Filed: 2006-01-17
Abstract: La invención se refiere a compuestos de la fórmula general (I), en la que la definición de los sustituyentes R1 a R5, A y X se enumeran en la Memoria Descriptiva y en las Reivindicaciones, así como sus sales fisiológicamente tolerables, procedimientos para la preparación de este compuesto y su uso como medicamento. Estos compuestos son inhibidores de la lipasa sensible a hormonas (HSL).
Patent UY-30611-A1 (UY)
Title: Evento de soja 3560.4.3.5 y composiciones y métodos de identificacion y/o deteccion del mismo
Inventor: ZHONG CATHY XIAOYAN
IPC: C12N5/14
Filed: 2007-09-26
Abstract: Composiciones y métodos relacionados con plantas de soja transgénicas con tolerancia a glifosato/inhibidores de la ALS. Específicamente, se proporcionan plantas de soja que tienen un evento 3560.4.3.5, que imparte tolerancia a glifosfato, y al menos un herbicida inhibidos de la ALS. La planta de soja que aloja el evento 3560.4.3.5 en la localizacion cromosomica mencionada comprende uniones genomicas que tienen al menos la secuencia de polinucleotidos de SEQ ID Ns 10 y/u 11.
Patent AT-516861-A1 (AT)
Title: Absorbervorrichtung
Inventor: SIEBEL LOTHAR DR ING
IPC: G10K11/172
Filed: 2015-01-30
Abstract: Absorbervorrichtung (1), insbesondere Absorberkörper, zur Schallabsorption, insbesondere in Gebäuden, wobei die Absorbervorrichtung (1) zumindest einen Hohlraum (2) aufweist, welcher zumindest bereichsweise von Außenwänden (3) der Absorbervorrichtung (1) begrenzt ist, wobei zumindest eine der Außenwände (3) zumindest bereichsweise durch zumindest eine aufgespannte, zumindest teilweise schalldurchlässige Membran (4) ausgebildet ist und die Absorbervorrichtung (1) zumindest eine platten- oder wandförmige Resonatormasse (5) aufweist, welche in voneinander distanzierten Bereichen verschieden weit von der Membran (4) entfernt angeordnet ist.
Patent ES-154688-A1 (ES)
Title: Procedimiento para la eliminacion de impurezas de naturaleza organica de liquidos acuosos, especialmente de soluciones de azucar
Filed: 1941-10-17
Abstract: Procedimiento para la eliminación de impurezas de naturaleza orgánica de líquidos acuososen especial de disoluciones de azúcarcaracterizado porque los líquidos acuosos son tratados con resinas sintéticas o naturales insolubles en el aguaque poseen una gran capacidad de absorción de estas impurezaspreferentemente con resinas insolubles en el agua precipitadas que no han sido sometidas a ningún o casi ningún tratamiento ulterior por secado.
Patent ES-177224-A1 (ES)
Title: Mejoras en o relativas a cables para comunicaciones eléctricas
IPC: H01B11/18
Filed: 1947-03-13
Abstract: Mejoras en cables de espacio de aire cuyo aislamiento comprende una más cuerdas aislantes de formación compuesta consistente de un núcleo central de material aislante fibroso que es flexible pero no estirable circundado por una cubierta de material aislante que normalmente es estirable.
Patent ES-261071-A1 (ES)
Title: Paints
IPC: C09D133/10
Filed: 1960-09-16
Abstract: A combined rust remover and primer comprises at least 20% by weight of extremely divided (atomized) metallic lead in a nonoxidized condition with at least 15% by weight of phosphoric acid in a solution of a thermoplastic film-forming resin, e.g. poly-2-ethoxyethyl methacrylate or polyvinyl acetate. The phosphoric acid may be used in its ortho, pyro or meta form. A suitable solvent for the methacrylate resin is a 3:1 mixture of ethanol and isopropanol containing 3 to 5% of water, and for polyvinyl acetate is ethanol. The methacrylate may have added thereto up to 20% of plasticizer ,e.g. trixylenyl phosphate or chlorinated diphenyl. Also present in the composition may be bentonite, mica, alkyl ammonium montmorillonite and titanium dioxide.
Patent ES-304559-A1 (ES)
Title: Inflatable buoy
IPC: B60T13/26
Filed: 1964-09-30
Abstract: An inflatable life-buoy comprises a frame of which at least some parts are tubular and provided with perforations 2, said frame extending e.g. round the neck of the wearer at least two inflatable sleeves 3 disposed around the frame and a coupling element 4 permitting respectively the gas-tight mounting of each sleeve 3 around the frame and the communication of the tubular parts of the frame with one or more sources of gas under pressure. As shown, the frame comprises tubes 1 having perforations 2. The tubes are surrounded by sleeves 3, both sleeves and tubes are attached at one end to either coupling element 8 or 9 which are a bayonet fit one with another and at the opposite end to a coupling element 4. Screwed into element 4 at 13 are bottles 5 containing gas, e.g. carbon dioxide under pressure. Levers 6 pivoted on pins 14 operate shells 7 which in turn open valves in the bottles 5. Gas escaping from the bottles passes through bore 12, tubes 1 and perforations 2 to inflate sleeves 3. A flexible tube (Fig. 3, not shown) may replace a bottle 5 so that the sleeves may be inflated by mouth. Fig. 2 (not shown) illustrates a frame having telescoping elements and two coupling elements.
Patent ES-315032-A1 (ES)
Title: Automatic frequency control systems
IPC: H03L7/183
Filed: 1965-07-07
Abstract: An automatic frequency control system wherein an oscillator 11, Fig. 1, feeds a divider 12 to provide an input to discriminator 13 at the same frequency as a reference oscillator 15, is characterized in that the division ratio of divider 12 is set by electronic switches which may be controlled by a digital input signal. This input signal may be fed via a series-parallel converter (25, Fig. 2, not shown) to control three triggers (241-243) which in turn control three electronic changeover switches (221-223) controlling a three-stage binary counter (211- 213) and a re-setting AND gate (23). The A.F.C. loop may include a search oscillator 17 acting on the variable reactance 14 controlling the frequency of oscillator 11.
Patent ES-315403-A1 (ES)
Title: Synergistic insecticidal compositions
IPC: A01N43/30
Filed: 1965-07-16
Abstract: Compounds having the general formula <FORM:1046209/A5-A6/1> wherein X represents halogen, cyano, cyanomethyl, hydroxymethyl, mercaptomethyl, thioamide <FORM:1046209/A5-A6/2> (R is an alkylcarbonyl group) -CH = CH - R1 (R1 is a pyridyl group) or - CCH and Y represents H or halogen are used as synergists in insecticidal compositions containing organophosphorus or carbamate type insecticides. Many examples of compounds having the above formula are specified and the preferred insecticides are Bidrin [Trade Mark, 3-dimethoxyphosphinyloxy -N,N-dimethyl-cis-crotonamide], 2-chloro-1-(2, 4-dichlorophenyl) vinyl diethyl phosphate, DDVP (dimethyldichlorovinyl phosphate) and 3, 4, 5-trimethylphenyl-N-methyl carbamate. The compositions also comprise a carrier and/or a surface active agent and may be in the form of a dust, wettable powder, granule, concentrate, solution emulsifiable concentrate, emulsion or aerosol. The weight ratio of synergist to insecticide is preferably 0.3 : 1 to 10 : 1.
Patent ES-317776-A1 (ES)
Title: Propulsion system for earth working vehicle
IPC: E02F9/02
Filed: 1965-09-24
Abstract: An earth working vehicle chassis is in two parts 1, 2 connected together by a telescopic device 2a provided with locating splines. Each chassis part has a pair of supporting wheels and a ground-engaging hydraulic jack provided with teeth 10. The chassis parts may be moved relatively to one another by an hydraulic ram, 8, 9 for locomotion under conditions where the driving wheels slip, one ground-engaging jack holding one chassis part stationary while the other chassis part moves. In a modification, the ground-engaging jacks have groundengaging spikes and are pivoted to the chassis so as to meet the ground at an angle, and so as to be pivotable in a vertical plane.
Patent ES-334164-A1 (ES)
Title: Antibiotic sl 2052
IPC: C12P1/02
Filed: 1966-12-05
Abstract: The invention relates to an antifungal antibiotic SL 2052 which is a colourless, crystalline neutral compound of formula C 23 H 24 O 8 melting point 237-238 C., specific rotation [[alpha]]20 D = +84 (C=0À54 in chloroform) having an ultraviolet spectrum with maxima at 256 mÁ (log #= 4À01) and 291À5 mÁ (log #=3À82) and shoulder at 360 mÁ (log #=1À86) in ethanol (Fig. 1, not shown), and infra-red spectrum according to Fig. 2 molecular weight 428 elementary analysis C=64À5%, H=5À6%, 0=29À9%. The antibiotic is produced by culturing strain NRRL 3195 of the fungus species Myrothecium roridum Tode ex Fries in a liquid nutrient medium under surface or submerged aerobic culture. In the example, a clarified broth of pH 4 to 5 is extracted with ethyl acetate and the solvent removed after washing with water. The residue is chromatographed on silica gel and eluted with chloroform/methanol (99: 1). The residue from selected fractions is crystallized from methanol/ether.
Patent ES-335493-A1 (ES)
Title: Polyamides stabilized with potassium or sodium cyanocuprates
IPC: C08K3/28
Filed: 1967-01-11
Abstract: Polyamides are heat-stabilized by incorporating a compound M y [Cu(CN) x ], where M is an alkali or alkaline earth metal, x is 2 to 6 and y is (x - 1)/valency of M, in amounts providing 0.0001 to 0.2 wt. per cent of copper, optionally in conjunction with iodine and/or phosphorus compounds, e.g. alkali metal or organic base iodides, alkyl or aryl iodides, phosphites and phosphines. The polyamides may also contain conventional additives such as pigments, especially cadmium pigments, dyes, light stabilizers, fillers such as glass or asbestos fibres, lubricants and mould release agents, and crystallization promoters and may be used for industrial fibres for fishing nets, drive belts, conveyer bands and tyre cords. In examples, Na 3 [Cu(CN) 4 ], K 3 [Cu(CN) 4 ] or K[Cu(CN) 2 ], with or without KI, triphenyl phosphine or tri-decyl phosphite is incorporated in nylon 6 (R.V. 3À12) with or without cadmium sulphide during or after its preparation.
Patent ES-337194-A1 (ES)
Title: Crank assembly for power steering
IPC: B62D5/10
Filed: 1967-02-23
Abstract: In power-assisted steering mechanism for a motor vehicle including a pin 48 connecting a rocker shaft lever 43 to a connecting rod 41 coupled to an hydraulic piston 42, a circlip 46 located in a groove in the connecting pin bore provided in the connecting rod 41 acts as a stop for the pin 48 when the pin is inserted through an access opening 49 in the housing 1, and an undercut conical spigot 50 on the pin 48 facilitates withdrawal of the pin through the opening 49. A second circlip 47 retains the pin 48 in the bore. A detachable cover plate 2 seals the access opening 49.
Patent ES-340631-A1 (ES)
Title: Abrasive scouring cleanser
IPC: C09K3/14
Filed: 1967-05-17
Abstract: An abrasive scouring cleanser composition in the form of a dry powder comprises at least 60% of a water-insoluble inorganic siliceous abrasive material having a particle size of less than 0-5 mm., 0À1-20% of an alkali metal monopersulphate, 0À5-15% of a water-soluble organic detergent stable in the presence of the monopersulphate and 0À1-10% of a watersoluble inorganic bromide. Suitably the alkali metal monopersulphate is the potassium or sodium salt or the triple salt 2KH50 5 , KHSO 4 , K 2 50 4 and the bromide is the sodium, potassium, lithium, magnesium or strontium salt. Suitable organic detergents are anionic, cationic, amphoteric or non-ionic in character and examples of each class are given. The abrasive material may be silica, feldspar, pumice, volcanic ash, diatomaceous earth, bentonite, talc or mixtures thereof. The cleanser composition may contain additional ingredients such as inorganic builder salts, sequestering agents (e.g. nitrilotriacetic acid, ethylenediamine tetra-acetic acid, diethylenetriamine penta-acetic acid and their salts), fillers (e.g. wood pulp, sawdust, magnesite or whiting), sodium carboxymethylcellulose, anticaking agents and optical brighteners.
Patent ES-343838-A1 (ES)
Title: Hydroxy-phenyl-acetic acid-delta3-piperideide
IPC: C07D295/185
Filed: 1967-08-04
Abstract: Novel derivatives of o-hydroxy phenylacetic acid of the general formula wherein R 1 is one or more hydrogen atoms, or one or more hydroxyl groups R 2 is alkyl, alkenyl or methylene-carboxylic acid alkyl ester group R 3 is identical with R 2 and R 2 and R 3 together with the nitrogen atom form a heterocyclic ring, which is optionally substituted by at least one alkyl group and/or at least one carboalkoxy group, are prepared by reacting the appropriately substituted o-hydroxyphenylacetic acid lactone with the corresponding amine of the formula NH(R 2 )R 3 in the presence of a solvent at between - 50 C. and + 150 C.
Patent ES-344303-A1 (ES)
Title: Apparatus for controlling glass temperatures
IPC: G01J5/04
Filed: 1967-08-21
Abstract: Glass sheets R are continuously annealed by passing through a lehr on rollers 27 and the temperature differential across the sheet is sensed by an infra-red detector 35 reciprocates transversely of the motion of the sheet by a reversible motor through gears 31 and controlled by abutments 112, 113 engaging limit switches. The results of the scanning are presented on a pen recorder 147 and are used to control the temperature differential across the sheet to give the required stress differential therein. The detector 35 lies in a fluid-filled trough in order to keep it cool and thus stabilize it.
Patent ES-345580-A1 (ES)
Title: Method for preparing methylene bis (thiocyanate)
IPC: C07C331/04
Filed: 1967-09-29
Abstract: Methylene bis(thiocyanate) is prepared by reacting a dihalomethane with an alkaline earth or alkali-metal thiocyanate at a temperature below 85 C. in an aqueous medium for a time sufficient to produce said methylene bis- (thiocyanate), the ratio of moles of thiocyanate radical to moles of dihalomethane being at least 2: 1. The dihalomethane preferably has at least one bromine or iodine atom, methylene bromide and chlorobromomethane being particularly preferred. An alkali metal thiocyanate such as NaSCN or KSCN is most suitably used. The impure product obtained from CH 2 ClBr may be purified by treating the crystals with a warm solution of a water-miscible organic solvent, e.g. isopropanol, and water to dissolve the pure methylene bis(thiocyanate) and crystallizing the pure product from this solution.
Patent ES-345695-A1 (ES)
Title: A method and device for selecting pulses
IPC: H03K5/02
Filed: 1967-10-03
Abstract: A method of selecting wanted pulses u having a long time constant fall time from spurious pulses P having a shorter time constant fall time comprises amplitude limiting and integrating the pulses so that the wanted pulses u are of greater amplitude than the spurious pulses P, then selecting the pulses u by means of an amplitude discriminator. The invention is applicable to separating wanted pulses u from a photo-multiplier from spurious pulses P which may be due to thermal agitation, ionization of gas or cosmic radiation. Pulses from a low resistance anode load, Fig. 8 (not shown) of a photo-multiplier are amplified by a cascode transistor amplifier, Fig. 9 (not shown) having an inductive collector load and passed via further transistor amplifiers (such as 44) to a clipping transistor 46, operating with grounded base and arranged so as to reduce the amplitude to one half in the case of the smallest amplitude pulses. The output of transistor 46 is amplified at 16 and fed to an integrator, Fig. 11 (not shown) the output of which is coupled by a further transistor amplifier to an amplitude discriminatior of unspecified type. It is stated that the invention can provide pulses to the amplitude discriminator in the ratio of 3:1 from initial pulses having an amplitude ratio of 1:15 and fall time constant ratio of 0À1:1.
Patent ES-346150-A1 (ES)
Title: Piston-cylinder assembly with seal means and corrosion preventing means therefor
IPC: F16D65/18
Filed: 1967-10-17
Abstract: To prevent the leading edge of a piston 2 from damaging the cylinder bore when heavy braking torque on a disc 4 tends to twist the piston from its axis, the end portions of the bore and piston are of enlarged and reduced diameter respectively, the sealing ring 9 being positioned never to communicate with the enlarged portion of the cylinder, and the step (14a, Fig. 2, not shown) between the two piston portions always lying in the enlarged cylinder portion for all positions of the piston. The sealing ring may be mounted in the cylinder, or on the piston (Fig. 3, not shown) and the length of the bore (a) between the ring and the enlarged portion is of the same order of size as the difference (D-d) in the diameters. The piston is chromium plated, and the cylinder cadmium plated.
Patent ES-347907-A1 (ES)
Title: Alkyl 2-methylpropenyl ketoxime carbamates
IPC: A01N47/24
Filed: 1967-12-02
Abstract: Insecticidal compositions comprise as active ingredient a compound of (formula wherein R is H or C 1-6 alkyl and R 1 is C 1-3 alkyl (see Division C2). The compositions may be dusts, wettable powders, emulsifiable concentrates, aqueous dispersions, solutions and flowable creams cantaining usual ingredients including other insecticides. The compositions may be used against boll weevil, confused flour beetle, house crickets, German cockroach, house flies, Mexican bean beetle, melon aphid, yellow mealworm and flesh flies. Synergists such as piperonyl butoxide, sesamex (Sesoxane), propyl isome (isosafrole condensation product with n-propyl maleate), n-octyl sulfoxide of isosafrole, sesame oil extracts and octachlorodipropyl ether, may be used.
Patent ES-351687-A1 (ES)
Title: Composite flexible shaft casing
IPC: F16C1/26
Filed: 1968-03-16
Abstract: A tubular casing for use with a flexible shaft comprises an inner liner 26, made, e.g. of nylon, a wire braid, consisting, e.g. of a plurality of low-carbon steel wires 30, wound upon the liner 26, preferably with successive wires 30 wound in opposite directions, and an outer cover 32 formed, e.g. by extruding polypropylene, the liner having integral resilient ribs 36 which extend longitudinally along the liner surface and which are intersected by the wires of the braid to prevent shifting of the braid in relation to the liner. The braid wires may consist of twisted strands wound at a pitch of less than 2 in. for wires between 0À01 and 0À02, and with an over and under weave, the ribs 36 having a height which approximates the diameter of the braid wires 30 which locally depress the apices of the ribs 36. In a modification, the inner liner 26 has a polygonal longitudinally extending - outer surface the apices of adjacent sides defining the resilient ribs.