baber/WOPTO huggingface dataset:
Patent EP-3923987-A1 (EP)
Inventor: MANENTI STÉPHANE
IPC: A61K45/00
Filed: 2020-02-13
Abstract: Resistance of acute myeloid leukemia (AML) cells to DNA damaging therapeutic agents is dependent on CHK1 protein levels. Here, the inventors demonstrate that in AML, CHK1 protein stability relies on the expression and activity of Ubiquitin Specific Protease 7 (USP7). CHK1 and USP7 levels are positively correlated in AML cell lines and primary patient specimens with high CHK1 protein levels. USP7 associates with CHK1, leading to its stabilization by deubiquitinylation, and this association is enhanced in response to cytarabine treatment. Pharmacological or RNA interference-mediated inhibition of USP7 significantly reduced AML proliferation  in vitro  and  in vivo , and increased AML cell death. It is important to note that USP7 inhibition synergized with cytarabine to kill AML cell lines. This is also the case in primary patient specimens with high CHK1 levels. Transcriptomic dataset analyses revealed that a USP7 gene signature is highly enriched in cells from AML patients at relapse, as well as in residual blasts from Patient Derived Xenograft (PDX) models treated with clinically relevant doses of cytarabine, strongly suggesting a relationship between USP7 expression and resistance to therapy. Finally, single cell analysis from AML patient at relapse  versus  diagnosis showed that a gene signature of the pre-existing subpopulation responsible for relapse is enriched in transcriptomes of patients with high USP7 level. Altogether, these data demonstrate that USP7 is a master regulator of CHK1 protein kinase in AML cells, and represents both a marker of resistance to chemotherapeutic treatments, as well as a potential therapeutic target to overcome treatment resistance.
Patent EP-3924287-A1 (EP)
Title: Rig, corner unit
Inventor: CLIVE-SMITH MARTIN
IPC: B65D90/00
Filed: 2020-02-11
Abstract: A rig for connecting or disconnecting container couplers to or from the four lower corner fittings of a shipping container, the rig has two pairs of corner units held in the required transverse special relationship by a structure extending between the two corner units of each pair to form two operating end modules. A base member has sockets and/or other connectors to secure the operating end modules in a plurality of longitudinal special relationships to enable the corner units of the modules to simultaneously engage all the four lower corner fittings of a range of containers of different lengths or using different types of couplers. Each corner unit includes an indexing means for engaging and manipulating an associated coupling to connect or disconnect the coupling to or from its associated container corner fitting.
Patent EP-3925334-A1 (EP)
Inventor: FISCHER SVEN
IPC: H04W64/00
Filed: 2020-02-14
Abstract: A Location Management Component (LMC) may be included in a gNB and connected to a gNB Central Unit (gNB-CU). The gNB-CU receives location related messages from any of (i) a UE via a gNB Distributed Units (gNB-DU), (ii) another gNB via an Xn interface, or (iii) a core network entity (e.g. AMF) via an NG interface. These messages can be transported in container messages (e.g., an RRC container for LPP messages sent to or received from a UE; an NG-AP container for messages sent to or received from an AMF, or an Xn-AP container for messages sent to or received from another gNB). The gNB-CU removes the location related messages from the container messages and forwards them to an LMC using F1-AP container messages. Location related messages sent from an LMC to other entities are transported in a reverse manner through a gNB-CU using corresponding container messages.
Patent EP-3942694-A1 (EP)
Inventor: ALHO TIMO
IPC: H03K4/56
Filed: 2020-03-18
Abstract: A digitally controlled oscillator (100), a synthesizer module (200), a synthesizer (300), and a method for producing an electrical audio signal are presented. The oscillator (100) comprises a digital processing unit (10) configured to generate a first pulse wave at a first output (PulseUp) of the processing unit (10), wherein the first pulse wave is arranged to include pulses at at least two different frequencies. The oscillator (100) further comprises a summing circuit (30) and a linear wave shaper (20). The output (PulseUp) of the processing unit (10) is connected to the summing circuit (30) which is arranged to produce a resultant signal based on at least the first pulse wave. The resultant signal is arranged to be fed into the linear wave shaper (20) which is arranged to produce an output signal at the output (OUT) of the oscillator (100) based on modifying the resultant signal.
Patent EP-3948232-A1 (EP)
Inventor: MEINERT TOBIAS
IPC: G01N21/41
Filed: 2020-03-12
Abstract: Die Erfindung betrifft ein Refraktometer zur Bestimmung des Brechungsindex eines Prozessmediums (PM), aufweisend zumindest einen optischen Lichtleiter (3,31,…) zur Herstellung einer optischen Verbindung zwischen einer Betriebseinheit (1) und einer Sondeneinheit (5) des Refraktometers. Ferner betrifft die Erfindung ein Verfahren zur Bestimmung des Brechungsindex eines Prozessmediums (PM) mit einem erfindungsgemäßen Refraktometer.
Patent EP-3956530-A1 (EP)
Inventor: SEMBELY XAVIER
IPC: E06B7/08
Filed: 2020-04-17
Abstract: L'invention concerne une lame (100, 100') de dispositif brise-soleil, remarquable en ce qu'elle est réalisée en une seule pièce comprenant : - des lamelles pleines (120, 120') sensiblement planes allongées, disjointes et parallèles, - des évidements discontinus (110, 110') séparant les lamelles pleines (120, 120'), - des entretoises de liaison (130, 130') assurant la liaison et l'entretoisement entre lamelles pleines (120, 120'), lesdits évidements (110, 110') étant encadrés par les bords des lamelles (120, 120') et les bords des entretoises de liaison (130, 130'). L'invention concerne également un procédé et un dispositif de fabrication d'une telle lame.
Patent EP-3953207-A1 (EP)
Title: Selbstkompensierte primäre induktionsspule
Inventor: MEINS JÜRGEN
IPC: B60L53/12
Filed: 2020-04-02
Abstract: Die Erfindung betrifft einen Spulenkörper (2) zum Erzeugen eines Magnetfelds für eine Spule. Der Spulenkörper ist um einen Kern, insbesondere einen Ferritkern (13), der Spule wickelbar und weist eine Bandschichtanordnung (3) mit einer ersten Leiterschicht (4), einer ersten elektrischen Isolationsschicht (5), einer zweiten Leiterschicht (6) und einer zweiten elektrischen Isolationsschicht (7) auf, wobei die Schichten aufeinander angeordnet sind. Die erste Leiterschicht (4) und die zweite Leiterschicht (6) weisen jeweils mindestens einen Abschnitt auf, der sich mit mindestens einem Abschnitt der anderen Leiterschicht zumindest teilweise überdeckt. Ebenso betrifft die Erfindung eine Primärvorrichtung (1) zum Erzeugen eines Magnetfelds für ein induktives Ladesystem, wobei die Vorrichtung mit mindestens einem derartigen Spulenkörper (2) und einem Spulenkern (13) ausgestattet ist.
Patent EP-3939113-A1 (EP)
Inventor: HOOPER JOEL
IPC: H01M10/643
Filed: 2020-03-13
Abstract: A battery module includes features to optimize cooling while providing electrical isolation and cell gas-venting channels. The battery module can include the integration of a heatsink in order to improve thermal performance. Thermally conductive pads can be provided to create an electrically isolated interface between a plurality of series-connected battery-cell lead plates, at different potentials, and the heatsink. Optimization, by stacking thin and thick thermally conductive pads, allows for creation of gas-venting channels along the positive cell terminal locations. In some arrangements, a plurality of fluid paths are disposed between the inlet and the outlet of the battery module to provide heat convective airflow through the battery module.
Patent EP-3946039-A1 (EP)
Inventor: GEORGIOU JULIUS
IPC: A61B10/00
Filed: 2020-04-03
Abstract: Devices, systems and related methods for direct and in-vivo monitoring and stimulation of the endometrial cavity include a plurality of sensing modalities incorporated on a set of flexible conductive filaments that allows its insertion in an endometrial cavity through the vagina. The flexible set of conductive filaments is in direct contact with the endometrium to maximize recording sensitivity and acquire direct readings, which correspond to the functionality of the endometrium and/or electrically stimulate endometrial peristalsis in a controlled manner. The same electrodes can be used for a controlled stimulation to strengthen weakened muscle tissue before and after medical and surgical interventions on the uterus, to reset to normal contractility. The methods and systems disclosed herein can be used to improve the chances of success for artificial insemination, including in-vitro fertilization, embryo transfer, and intrauterine insemination, diagnostic tests, and may further improve the overall understanding of endometrial functionality.
Patent EP-4107621-A1 (EP)
Title: Virtualized hardware and methods for leveraging virtualized hardware with munition support software
Inventor: WALKER BRAD A
IPC: G06F11/26
Filed: 2020-03-17
Abstract: An apparatus includes at least one memory (604, 610, 612) configured to store a virtualization associated with a programming and test platform (100, 200) and a munition (102). The virtualization includes a virtual machine (304, 404) containing first software or firmware instructions (310, 410) associated with the programming and test platform and second software or firmware instructions (308, 408) that control behavior of the programming and test platform relative to the munition. The virtualization also includes a virtual representation (312, 418) of the munition. The virtualization further includes one or more virtual communication channels (316, 416) configured to communicatively couple the virtual machine and the virtual representation of the munition. The apparatus also includes at least one processor (602) configured to execute the virtualization and simulate the programming and test platform and the munition on the apparatus.
Patent EP-3967062-A1 (EP)
Inventor: BERGGREN ANDERS
IPC: H04W72/04
Filed: 2020-04-09
Abstract: A method of operating a UE includes receiving a configuration of multiple bandwidth parts. Each bandwidth part of the multiple bandwidth parts is associated with a respective access node of multiple access nodes. The method also includes receiving positioning signals on each bandwidth part of the multiple bandwidth part from the respectively associate access node of the multiple access nodes. Said receiving is in accordance with the configuration. The method also includes participating in positioning of the UW based on said receiving of the positioning signals.
Patent EP-3970239-A1 (EP)
Title: Élément de contact enfichable, produit semi-fini pour la fabrication d'un élément de contact enfichable et procédé pour la fabrication d'un élément de contact enfichable
Inventor: ECKSTEIN MARCEL
IPC: H01R13/04
Filed: 2020-05-14
Abstract: L'invention concerne un élément de contact enfichable (100) pour établir une connexion électriquement conductrice, comprenant une section de sertissage pour établir une connexion électriquement conductrice avec une ligne et au moins un mandrin de contact enfichable (90) pour établir une connexion électriquement conductrice détachable avec une boîte de contact (70). L'élément de contact enfichable (100) est constitué d'une seule pièce et le mandrin de contact enfichable (90) présente une languette (91) qui se trouve au moins partiellement à l'intérieur et qui est entourée au moins partiellement par la zone extérieure de la lame de contact (92), de sorte qu'il se forme au moins partiellement un pliage en sandwich du mandrin de contact enfichable (90) avec une construction en matériau au moins en deux couches. En outre, l'invention concerne un produit semi-fini en forme d'arc (100') pour la fabrication de l'élément de contact enfichable (100) selon l'invention, ainsi que le procédé de fabrication de l'élément de contact enfichable.
Patent EP-3939288-A1 (EP)
Inventor: JOHN SAM
IPC: H04N19/179
Filed: 2020-05-19
Abstract: A learning model is trained for rate-distortion behavior prediction against a corpus of a video hosting platform and used to determine optimal bitrate allocations for video data given video content complexity across the corpus of the video hosting platform. Complexity features of the video data are processed using the learning model to determine a rate-distortion cluster prediction for the video data, and transcoding parameters for transcoding the video data are selected based on that prediction. The rate-distortion clusters are modeled during the training of the learning model, such as based on rate-distortion curves of video data of the corpus of the video hosting platform and based on classifications of such video data. This approach minimizes total corpus egress and/or storage while further maintaining uniformity in the delivered quality of videos by the video hosting platform.
Patent EP-3982718-A1 (EP)
Inventor: ASHKENAZI VARDA
IPC: A01H6/82
Filed: 2020-06-12
Abstract: The invention relates to a Solanum lycopersicum plant resistant to Tomato Brown Rugose Fruit virus comprising in its genome the combination of the Tm-1 resistance gene on chromosome 2, and at least one quantitative trait locus (QTL) chosen from QTL3 on chromosome 11, QTL1 on chromosome 6 and QTL2 on chromosome 9, that independently confer to the plant foliar and/or fruit tolerance to TBRFV, wherein said QTLs are present in the genome of a plant of the seeds HAZTBRFVRES1 NCIMB accession number 42758. The combination of at least one of these QTLs with the Tm-1 gene delays, reduces or inhibits the replication or multiplication of the virus in the plants of the invention. The invention is also directed to parts of these plants with TBRFV resistance phenotype, as well as progeny, to the use of these plants for introgressing the resistance in another genetic background, as well as to different methods for obtaining tomato plants or seeds with increased resistance to Tomato Brown Rugose Fruit virus.
Patent EP-3973487-A1 (EP)
Inventor: TARRANT DECLAN
IPC: G06Q10/08
Filed: 2020-05-20
Abstract: Aspects of the present disclosure provide streamline techniques to alert sales personal/associate of an item in need of replenishment on the sales floor or in the stock room, and provide real-time data indicating units of an item within a retail location. The present disclosure provides a method, system and computer readable medium for inventory management utilizing radio-frequency identification (RFID) technology. The method may include detecting a first signal from an electronic product code (EPC) tag at a first location; generating a value of an inventory count based on the first signal; detecting a second signal from the EPC tag at a second location; updating the value of the inventory count based on the second signal; comparing the updated value to a threshold value, and when the updated value meets the threshold; and sending a notification of a task to a mobile device.
Patent EP-3975681-A1 (EP)
Inventor: FOGELIN JONAS
IPC: A01B63/111
Filed: 2020-05-28
Abstract: The document discloses an agricultural implement, comprising a main frame (11), which carries a plurality of soil working tools (32), a first support frame (12a), which is pivotally connected to the main frame (11) via a first support frame joint (21a) and which carries at least one first rolling ground support (31a), such as a wheel or a roller, a control lever (13) rotatably connected to the main frame (11) via a control lever joint (22), a support frame control link (14) rotatably connected to the control lever via a first support frame control link joint (23a) and which is pivotally connected to the support frame (12) via a second support frame control link joint (23b) so that rotation (V1) of the control lever (13) around the control lever (22) provides rotation (V2) of the first support frame (12a) relative to the main frame (11), wherein the control lever (13) is rotatable in a first direction of rotation (V1) so that the first support frame control link joint (23a) can pass a line (C1 ) through rotation centers of the control lever joint (22) and the second support frame control link joint (23b) and wherein the first support frame (12a), when the first support frame control link joint (23a) passes the line (C1), changes direction of rotation (-V2).
Patent EP-4038436-A1 (EP)
Inventor: TAMMELA SIMO KAARLO
IPC: G02B27/01
Filed: 2020-06-17
Abstract: L'invention concerne des dispositifs, tels que des dispositifs de réalité augmentée et/ou de réalité virtuelle qui utilisent des guides d'ondes optiques. Par exemple, un premier guide d'ondes optique est configuré pour recevoir de la lumière selon un angle d'incidence et un second guide d'ondes optique positionné dans une relation non parallèle au premier guide d'ondes optique. Le second guide d'ondes optique peut être configuré pour recevoir la lumière à travers le premier guide d'ondes optique à un premier emplacement au niveau de l'angle d'incidence, transmettre la lumière à l'intérieur du second guide d'ondes optique, et délivrer la lumière à partir d'un second emplacement en retour vers le premier guide d'ondes optique au niveau de l'angle d'incidence.
Patent EP-3742733-A1 (EP)
Inventor: PALURI SEETHAL
IPC: H04N19/58
Filed: 2020-01-02
Abstract: Embodiments of the disclosure provide methods and devices for decoding video signals using inter prediction. According to an embodiment of the disclosure, a method for processing a video signal comprises constructing a reference picture list of a current picture in the video signal and performing a prediction for a current picture by using the reference picture list, wherein constructing the reference picture list comprising, if a first entry of the reference picture list corresponds to a short-term reference picture (STRP), obtaining a picture order count (POC) difference between a picture related to the first entry and another picture, and if a second entry of the reference picture list corresponds to a long-term reference picture (LTRP), obtaining a POC modulo value of a picture related to the second entry. A reference picture list for identifying a picture may be generated in a simplified and effective manner. Thus, the compression performance may be increased, and the computation time may be decreased.
Patent EP-3987825-A1 (EP)
Inventor: YANG ZIYU
IPC: H04S7/00
Filed: 2020-06-17
Abstract: An audio renderer for rendering a multi-channel audio signal having M channels to a portable device having S independent speakers, comprising a first matrix application module for applying a primary rendering matrix to the input audio signal to provide a first pre-rendered signal suitable for playback on the multiple independent speakers, a second matrix application module for applying a secondary rendering matrix to the input audio signal to provide a second pre-rendered signal suitable for playback on the multiple independent speakers, a channel analysis module configured to calculate mixing gain according to a time-varying channel distribution, and a mixing module configured to produce a rendered output signal by mixing the first and second pre-rendered signals based on the mixing gain.
Patent EP-3914067-A1 (EP)
Inventor: DICKER STEPHEN MICHAEL
IPC: C12N7/04
Filed: 2020-01-22
Abstract: L'invention concerne des procédés et des systèmes de fabrication de vecteurs viraux (par exemple, des vecteurs lentiviraux) à l'aide d'un dispositif de diffusion de lumière statique en ligne avec un procédé de fabrication.
Patent EP-3919189-A1 (EP)
Inventor: FAN SHIGANG
IPC: B05D7/24
Filed: 2020-01-14
Abstract: The present disclosure relates to a wood article and a process for preparing the wood article. In particular, the present disclosure relates to a wood article comprising a wood substrate comprising acidic substances and having at least one major surface; an adhesion promoting layer directly applied on the major surface of the wood substrate; and a Michael Addition curing coating applied on the adhesion promoting layer, wherein the adhesion promoting layer is formed by a composition comprising a functional silane comprising amino and/or imino functional groups; and wherein the Michael Addition curing coating is formed from a two-component curable coating composition.
Patent EP-4003584-A1 (EP)
Inventor: BRENNOM STEPHEN
IPC: B01J19/30
Filed: 2020-07-31
Abstract: Selon des modes de réalisation, un appareil de distribution de particules solides dans un tube comprend un élément central et une pluralité d'éléments amortisseurs reliés à l'élément central. Chaque élément amortisseur comprend une boucle s'étendant à l'opposé de l'élément central. Chaque boucle est disposée sur l'élément central s'étendant d'une première position sur l'élément central à une seconde position sur l'élément central différente de la première position dans une direction longitudinale de l'élément central.
Patent EP-4013975-A1 (EP)
Title: Elastisches lager
Inventor: Zäch Martin
IPC: F16F1/38
Filed: 2020-07-22
Abstract: Die Erfindung betrifft ein elastisches Lager mit einem Innenkörper (IR1, IR2), einem Außenkörper (AR1, AR2) und mit einer elastischen Schicht (GUM1, GUM2). Der Außenkörper (AR1, AR2) umfasst den Innenkörper (IR1, IR2), so dass der Außenkörper (AR1, AR2) und der Innenkörper (IR1, IR2) eine gemeinsame Längsachse (x) aufweisen, die die Lager-Längsachse (LA1, LA2) als erste Raumachse eines räumlichen Koordinatensystems bildet. Die elastische Schicht (GUM1, GUM2) ist zwischen dem Außenkörper (AR1, AR2) und dem Innenkörper (IR1, IR2) positioniert. In Richtung einer zweiten Raumachse (z) weisen der Außenkörper (AR1, AR2) und der Innenkörper (IR1, IR2) zueinander einen minimalen Abstand auf, der frei von der elastischen Schicht (GUM1, GUM2) ist. In Richtung einer dritten Raumachse (y) weisen der Außenkörper (AR1, AR2) und der Innenkörper (IR1, IR2) zueinander einen gleichen Abstand auf, in dem die elastische Schicht (GUM1, GUM2) angeordnet ist, um den gleichen Abstand aufzufüllen.
Patent EP-3923981-A1 (EP)
Inventor: TUOHY VINCENT KEVIN
IPC: A61K39/00
Filed: 2020-02-13
Abstract: Compositions comprising an antigen, a carbohydrate, and a metabolizable oil, methods of administering such compositions to a subject, methods of making such compounds, and related compositions, methods, and uses.
Patent EP-4013666-A1 (EP)
Inventor: BERTH STEPHANE
IPC: B62D35/02
Filed: 2020-08-10
Abstract: A rear deflector (DR) is fitted to a wheeled vehicle comprising a structure (SV), having a rear panel provided with N first fastening tabs, and a rear bumper (PCR) comprising N second fastening tabs (PF2). This rear deflector (DR) comprises a rear edge (BR) having N regions against which there bear, on an underside (FI), the N second fastening tabs (PF2) and which are provided with N holes which, just like the first and second (PF2) fastening tabs, are traversed by N screws securely fixing the rear bumper (PCR) to the rear deflector (DR) and the latter to the rear panel. This rear edge (BR) also comprises on its underside (FI), in each of the N regions, a housing (LP) comprising a hole and guiding the positioning of, and housing, one of the second fastening tabs (PF2).
Patent EP-3928285-A1 (EP)
Inventor: XIE YIBIN
IPC: G06T5/00
Filed: 2020-02-18
Abstract: A method of analyzing computed tomography (CT) images comprises receiving an initial CT image of an object, identifying calcium-free regions and a calcified region in the initial CT image of the object, generating a calcium-free image patch, and applying the calcium-free image patch to the initial CT image patch to produce a final CT image. The initial CT image shows a calcium deposit and a target structure in the object. The calcified region in the initial CT image shows the calcium deposit in the object obscuring a portion of the target structure. The calcium-free regions show the remaining portions of the target structure. The calcium-free image patch corresponds to the calcified region in the initial CT image. The final CT image shows the calcium-free image patch and the calcium-free region from the initial CT image. The calcium-free image patch is generated and applied using a convolutional neural network.