Patent SG-11201901548S-A (SG)
Title: Anti-tim-3 antibodies and use thereof
Inventor: XUE LIU
IPC: C07K16/28
Filed: 2017-08-25
Abstract: 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT 0111111010 0111 °nolo III 011101110111 O II oimIE (10) International Publication Number WO 2018/036561 Al (51) International Patent Classification: CO7K 16/28 (2006.01) A61P 35/00 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/CN2017/099098 (22) International Filing Date: 25 August 2017 (25.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2016/096924 26 August 2016 (26.08.2016) CN (71) Applicant: BEIGENE, LTD.; c/o Mourant Ozannes Cor- porate Services (Cayman) Limited, 94 Solaris Avenue, Ca- mana Bay, Grand Cayman KY1-1108 (KY). (72) Inventor; and (71) Applicant (for SC only): ZHANG, Tong [CN/CN]; No.30 Science Park Road, Zhongguancun Life Science Park, Changping, Beijing 102206 (CN). (72) Inventors: XUE, Liu; No.30 Science Park Road, Zhong- guancun Life Science Park, Changping, Beijing 102206 (CN). LIU, Qi; No.30 Science Park Road, Zhongguan- cun Life Science Park, Changping, Beijing 102206 (CN). PENG, Hao; No.30 Science Park Road, Zhongguancun Life Science Park, Changping, Beijing 102206 (CN). WEI, Min; No.30 Science Park Road, Zhongguancun Life Science Park, Changping, Beijing 102206 (CN). LI, Kang; No.30 Science Park Road, Zhongguancun Life Science Park, Changping, Beijing 102206 (CN). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) = (74) Agent: WU, FENG & ZHANG CO.; Room 305, Tower B, Beijing Aerospace Cpmiec Building, Beijing 100080 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: ANTI-TIM-3 ANTIBODIES AND USE THEREOF 0 (57) : Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The \" anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders 0 that may be modulated by Tim-3-mediated functions.