Patent SG-11201804896Q-A (SG)
Title: Novel dosing regimens of celgosivir for the prevention of dengue
Inventor: VASUDEVAN SUBHASH
IPC: C07D471/00
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 111110111010111011111100111110 111110111011# 11 International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/100505 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: LOW, Jenny; c/o Singapore Health Services PTE Ltd., 31 CO7D 471/00 (2006.01) A61P 31/12 (2006.01) Third Hospital Avenue, #03-03 Bowyer Block C, 168753 A61K 31/437 (2006.01) (SG). CHAN, Kitti Wing Ki; c/o National University of Singapore, 21 Lower Kent Ridge Road, 119077 (SG). (21) International Application Number: PCT/US2016/065719 (74) Agents: DUNSTON, Erin M. et al.; Buchanan Ingersoll & Rooney PC, P. 0. Box 1404, Alexandria, Virginia 22313- (22) International Filing Date: 1404 (US). 9 December 2016 (09.12.2016) (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (30) Priority Data: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 62/266,119 11 December 2015 (11.12.2015) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (71) Applicants: 60° PHARMACEUTICALS LLC [US/US]; KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 1025 Connecticut Avenue NW, Washington, District of MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Columbia 20036 (US). NATIONAL UNIVERSITY OF NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 119077 (SG). SINGAPORE HEALTH SERVICES PTE TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, LTD. [SG/SG]; 31 Third Hospital Avenue, #03-03 Bowyer ZA, ZM, ZW. Block C, 168753 (SG). (84) Designated States (unless otherwise indicated, for every (72) Inventors: VASUDEVAN, Subhash; c/o National Univer- kind of regional protection available): ARIPO (BW, GH, sity of Singapore, 21 Lower Kent Ridge Road, 119077 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (SG). DOW, Geoffrey S.; c/o 60° Pharmaceuticals LLC, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, = 1025 Connecticut Avenue NW, Washington, District of TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Columbia 20036 (US). WATANABE, Satoru; c/1 Nation- al University of Singapore, 21 Lower Kent Ridge Road, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 119077 (SG). 001, Eng Eong; c/o National University of SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = Singapore, 21 Lower Kent Ridge Road, 119077 (SG). GW, KM, ML, MR, NE, SN, TD, TG). = [Continued on next page] = (54) Title: NOVEL DOSING REGIMENS OF CELGOSWIR = = = _ = = = = Fig. 1 = A EDEN1 (7 x 10 7 pfu) 100 100 FOR THE PREVENTION OF DENGUE OR' - (1 x 10 8 EDEN2 OH (0 S221 pfu) (2 x 10 4 pfu) 11 80 60 40 111 ) 20 © ici 80 -EF Virus • • 60 DI• Virus (+ 60og AO) 0 20 100 80 -e-Virus 60 -0. Virus (+ 5Ong Ab) 40 20 - t 0r• Virus ... Virus (+ 10og Ab) 0 0 0 111) 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 © Days post infection Days post infection Days post infection © 11 IN Il (57) : Methods of preventing a disease resulting from a dengue virus (DENY) infection in a human subject, comprising ad - 0 ministering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I); \" a compound of Formula (I) can be first administered to an asymptomatic human subject followed by subsequent doses administered C at least once daily. The methods of the invention can be used to prevent a disease resulting from primary and secondary DENY 1-4 viral infections. WO 2017/100505 Al MIDEDIMOMOIDEIR01013010111MINIMMOVOIMIE Declarations under Rule 4.17: Published: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) — with international search report (Art. 21(3)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii))