baber/WOPTO huggingface dataset:
Patent UA-125510-C2 (UA)
Title: Process for the preparation of pegylated drug-linkers and intermediates thereof
Inventor: MAO YUNYU
Filed: 2017-03-24
Abstract: The present invention provides improved processes tor the preparation of auristatin drug-linkers with a PEG unit, as well as intermediates thereof.
Patent UA-123455-C2 (UA)
Title: N-(3,4-ДИХЛОРФЕНІЛ)-N<sup>1</sup>-(4<sup>1</sup>-ЕТИЛФЕНІЛ)-6-МОРФОЛІН-4-ІЛ-[1,3,5]-ТРИАЗИН-2,4-ДІАМІН, ЩО ПРОЯВЛЯЄ АНТИВІРУСНУ АКТИВНІСТЬ ЩОДО ВІРУСУ MIDDLE EAST CORONAVIRUS (HCOV-EMC)
Filed: 2018-12-27
Abstract: N-(3,4-дихлорфеніл)-N1-(41-етилфеніл)-6-морфолін-4-іл-[1,3,5]триазин-2,4-діамін, що проявляє антивірусну активність щодо вірусу Middle East Coronavirus (HCoV-EMC). Винахід належить до фармацевтичної хімії та медицини, а саме, до фармакологічно активних речовин, що проявляють антивірусну активність, конкретно до N-(3,4-дихлорфеніл)-N1-(41-етилфеніл)-6-морфолін-4-іл-[1,3,5]триазин-2,4-діаміну. Експериментальне визначення противірусної активності було проведено в рамках скринінгової програми Національного Інституту Здоров'я США (NIH/NIAID) у Південному дослідному інституті США (Southern Research Institute-SRI, Birmingham, Alabama) під керівництвом проф. Дейла Бернарда з університету штату Юта (Dale Barnard, Utah State University). Антивірусну активність синтезованого діаміну щодо вірусу Middle East Coronavirus (HCoV-EMC) оцінювали за барвником нейтральним червоним і за візуальною методикою оцінки. Ефективність зазначеної сполуки виражали показниками ЕС50, ІС50 та SI, які визначали в дослідах in vitro. Показано, що пригнічення вірусу Middle East Coronavirus (HCoV-EMC) сполукою N-(3,4-дихлорфеніл)-N1-(41-етилфеніл)-6-морфолін-4-іл-[1,3,5]триазин-2,4-діамін у пробі за нейтральним червоним ЕС50 становить 0.32 мкг/мл, а візуальною методикою оцінки ЕС50=0,56 мг/мл, індекси селективності досліджуваної речовини становлять відповідно SI=27 тa SI=12.
Patent UA-126397-C2 (UA)
Title: Aerosol-generating device and aerosol-generating system with inductive heating system with efficient power control
Inventor: STURA ENRICO
IPC: A24F40/465
Filed: 2018-06-27
Abstract: There is provided an efficient system for providing power to an inductor and susceptor in an inductively heated aerosol-generating device. The aerosol-generating device comprises: one or more DC power sources; a load network comprising an inductor and a capacitor connected in series; first drive circuitry connected to the one or more DC power sources and connected across the load network and configured to provide a first voltage drop across the load network; second drive circuitry connected to the one or more DC power sources and connected across the load network and configured to provide a second voltage drop across the load network, the second voltage drop being in an opposite direction to the first voltage drop; and a controller connected to the first and second drive circuitry and configured to control the first and second drive circuitry so that both the first and second voltage drops are provided across the load network periodically and so that the second voltage drop is not provided across the load circuit simultaneously with the first voltage drop. The arrangement of first and second drive circuitry alternately supplying voltage drops in different directions provides a time varying voltage and allows for efficient use of power supplied by the power source or sources.
Patent UA-125840-C2 (UA)
Title: Біозахисна композиція на основі метаболітів ґрунтових стрептоміцетів та асоціації ентомопатогенних бактерій з біозахисними і імунопротекторними властивостями
Filed: 2020-12-18
Abstract: Винахід належить до сільськогосподарської біотехнології, а саме стосується способу використання метаболітів ґрунтових стрептоміцетів, продуктів їх життєдіяльності, що містять широкий спектр біологічно активних сполук, та асоціації в біозахисній композиції ентомопатогенних бактерій, а саме біозахисної композиції для обробки рослин на основі метаболітів ґрунтових стрептоміцетів, зокрема етанольного екстракту біомаси штаму Streptomyces avermitilis IMB Ас-5015 з концентрацією авермектинів 100 мкг/мл та супернатант культуральної рідини зазначеного вище штаму у співвідношенні 1:1, яка додатково містить у своєму складі високоактивну асоціацію ентомопатогенних бактерій Bacillus thuringiensis Mbt-6 IMB В-7804 і Bacillus thuringiensis Mbt-8 1MB B-7805 у співвідношенні 1:35.
Patent UA-78275-C2 (UA)
Title: Oxa- and thiadiasols and their use as inhibitors of matrix metalloproteinases
Inventor: ASCOW ADREW PAUL
IPC: A61P19/02
Filed: 2003-02-20
Abstract: Compounds formula (IA) or (IB), wherein W represents HO(C=O)-, HONH(C=O)- or H(C=O)N(OH)-; X represents -O- or -S-; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12. (IA) (IB)
Patent DE-10119069-C5 (DE)
Title: Klappverdeck für ein Cabriolet-Fahrzeug
Inventor: OBENDIEK KLAUS
IPC: B60J7/02
Filed: 2001-04-18
Granted: 2005-09-22
Abstract: Klappverdeck
für ein
Cabriolet-Fahrzeug, umfassend  ein vorderes Dachteil (1 ),  ein
mittleres Dachteil (2) und  ein hinteres Dachteil (3),  wobei
das vordere Dachteil (1), das mittlere Dachteil (2) und das hintere
Dachteil (3) gleichsinnig übereinander
verlagerbar sind,  wobei das vordere Dachteil (1), das mittlere
Dachteil (2) und das hintere Dachteil (3) gemeinsam in eine Ablageposition
in einem Heckbereich des Cabriolet-Fahrzeugs verschwenkbar sind,  wobei
an zumindest einem der Dachteile (1, 2, 3) eine Linearführung (2a,
3b) vorgesehen ist, wobei ein Viergelenk (11, 12) mit seiner Basis
(11d, 12d) entlang der Linearführung
(2a, 3b) beweglich aufgenommen ist und die Koppel (11a, 12a) des
Viergelenks mit einem anderen der Dachteile (1, 2, 3) verbunden
ist, und   wobei das mittlere Dachteil (2) in der Ablageposition
unter dem hinteren Dachteil (3) zu liegen kommt.
Patent DE-112007000013-C5 (DE)
Title: Dampfgenerator zum Einbau in eine Waschmaschine
Inventor: KIM JAE MUN
IPC: D06F39/04
Filed: 2007-01-23
Granted: 2014-01-30
Abstract: Dampfgenerator zur Montage in einer Waschmaschine oder einen Trockner, der Dampf verwendet, umfassend: eine Wasserkammer (W) zum tatsächlichen Aufnehmen von Wasser, an der ein Heizer (200) zum Erwärmen des Wassers angebracht ist; und eine Dampfkammer (S) zum Aufnehmen von Dampf, der beim tatsächlichen Erwärmen des Wassers erzeugt wird, wobei der Dampf zur Zuführung in eine Trommel der Waschmaschine bzw. des Trockners vorgesehen ist, wobei die Wasserkammer (W) eine Länge in der vertikalen Richtung (vertikale Länge) aufweist, die relativ größer als eine Länge in der horizontalen Richtung (horizontale Länge) ist.
Patent RU-2670831-C9 (RU)
Inventor: Stareeva Anna Mikhajlovna
IPC: B05B1/34
Filed: 2015-09-25
Granted: 2018-11-29
Abstract: Изобретение относится к средствам распыливания жидкостей, растворов. Вихревая форсунка содержит корпус с камерой завихрения и сопло. Корпус выполнен в виде подводящего штуцера с центральным отверстием и жестко соединенной с ним и соосной цилиндрической гильзой с внутренней резьбой и расширительной камерой, соосной корпусу. Соосно корпусу в его нижней части подсоединено к гильзе посредством резьбы сопло, выполненное в виде перевернутого стакана. В днище стакана выполнен турбулентный завихритель потока жидкости с по крайней мере двумя наклонными к оси сопла вводами в виде цилиндрических отверстий, расположенных в торцевой поверхности сопла, где также выполнено центральное цилиндрическое дроссельное отверстие, соединенное со смесительной камерой сопла, последовательно соединенной с диффузорной выходной камерой. В диффузорной выходной камере установлен рассекатель, выполненный в виде по крайней мере трех спиц. Каждая из спиц одним концом закреплена на внешней поверхности диффузорной выходной камеры перпендикулярно образующим ее поверхности, а другим - в поверхности тела вращения в виде шара, ось которого совпадает с осью диффузорной выходной камеры. Тело вращения расположено в нижней части за срезом диффузорной выходной камеры. К торцевой поверхности цилиндрической гильзы, соосной с корпусом, соосно диффузорной камере прикреплен диффузор, поверхность которого лежит в плоскости, находящейся ниже поверхности тела вращения рассекателя. Поверхность тела вращения, выполненного в виде шара, установленного на оси с возможностью вращения, выполнена перфорированной. На оси с возможностью вращения установлены элементы, осуществляющие его вращение, в виде отрезков винтовых лопастей. Техническим результатом изобретения является повышение эффективности распыления путем увеличения факела распыла. 1 ил.
Patent DK-97584-D0 (DK)
Inventor: GOUGH PETER ROBERT
IPC: B21C43/04
Filed: 1984-02-24
Abstract: The invention provides for surface cleaning of wire rod and the like by holding the wire (10) under tension while passed through a die system (16) and vibrating the wire (10) transversely so that it is abraded by the surface. Cleaning liquid flushes the die bore.
Patent DK-113186-D0 (DK)
Inventor: BRUECKNER HERMANN
IPC: F22G5/12
Filed: 1986-03-12
Abstract: 1. Steam generator having a temperature-regulated parallel pipe system with injection coolers (12, 13) which are connected upstream of the end heating surfaces (7, 8, 9, 10) of the individual lines (3, 4, 5, 6) of the parallel pipe system, having a measuring sensor (39) for the temperature of the mixed steam downstream of the parallel pipe system, said sensor being connected to the steam collecting line (11) which accomodates the individual lines, and having a regulating device for the injection coolers, which device is controlled by the measuring sensor and a desired value input, there being associated with each of the lines (3 to 6) which are connected in parallel a separate temperature measuring sensor (37, 38) for the steam temperature, said temperature measuring sensors being connected to a temperature regulator (40) which controllably opens the injection cooler (12, 13) of the line with the highest steam temperature and controllably closes the injection cooler (12, 13) of the line with the lowest steam temperature, there being associated with the hot ends of the individual parallel pipes (17 to 26) of each line (3 to 6) separate temperature measuring sensors (27 to 36) which are connected to a monitoring logic system (42, 43) which determines the measured value with the highest temperature and compares it with a fixedly preset reference value (44, 45) for the temperature and controllably opens the associated injection cooler (12, 13) when the reference value is exceeded, with priority over other control commands.
Patent DK-122591-D0 (DK)
Inventor: GOULD COLIN ANTHONY
IPC: G02B6/38
Filed: 1991-06-21
Abstract: PCT No. PCT/GB89/01494 Sec. 371 Date Jul. 23, 1991 Sec. 102(e) Date Jul. 23, 1991 PCT Filed Dec. 13, 1989 PCT Pub. No. WO90/07139 PCT Pub. Date Jun. 28, 1990.An optical cable is terminated onto a ferrule which is secured to the tensile element of the cable. The components of the cable are clamped in order to a tail-piece of the ferrule. This prevents relative displacement of cable elements. The termination can be standardised for different cables which can then be connected by securing the tail-pieces of their terminations in a connector tube. The joint is particularly suitable for use with submarine cables.
Patent DK-154290-D0 (DK)
Inventor: GODDWIN ROSS P
IPC: H04B1/38
Filed: 1990-06-26
Abstract: A battery housing (105) with an integral latch (201) and a cantilevered spring finger positive displacement mechanism (320, 321) is disclosed. The slide-on battery is captivated by guide rails (307-312) on each side of the mating surface of the battery housing. When the battery is properly located, a torsion bar latch (201) locks the battery in place. When the latch is activated by the user to remove the battery, cantilevered spring fingers (320, 321) force the battery housing away from its locked position. <MATH>
Patent DK-197685-D0 (DK)
Inventor: KADIN SAUL BERNARD
IPC: C07D491/04
Filed: 1985-05-02
Abstract: 2-Oxindole-1-carboxamide intermediates of the formula: <CHEM>  wherein X and Y are each hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl or 6-trifluoromethyl, provided that X and Y are not both hydrogen; and R is alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl or a group of the formula <CHEM> wherein R<1> and R<2> are each hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons or trifluoromethyl.
Patent DK-212688-D0 (DK)
Inventor: WARRIN GEORGE E
IPC: A61C3/025
Filed: 1988-04-19
Abstract: A single handpiece that can be used in multiple dental treatments is provided. The handpiece comprises a housing having a coil for producing an electromagnetic or electrostrictive field in the housing, and a number of inserts that react with the electromagnetic or electrostrictive field and can be used with the housing to complete the handpiece. A switching system used with the handpiece, which electrically recognizes the particular insert used with the housing provide for automatically controlling circuitry that determines which of a number of materials and medicaments are to be delivered to the handpiece for use with a particular insert. Circuitry which provides better control of the ultrasonic insert in the handpiece is also provided.
Patent DK-234787-D0 (DK)
Inventor: WEGNER GERHARD
IPC: B05D1/20
Filed: 1987-05-08
Abstract: This invention relates to a process, which comprises spreading a metallomacrocyclic polymer dissolved in an organic, water-immiscible solvent on a water surface, removing the solvent to form a monomolecular, uniformly oriented film of said polymer on the surface of the water, immersing a substrate in the water, and withdrawing the substrate from the water, whereby said polymer film is transferred from the water surface to the substrate.
Patent DK-253583-D0 (DK)
Inventor: LAFON LOUIS
IPC: A61K31/535
Filed: 1983-06-03
Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A novel benzhydrylsulfinylacetamide derivative characterized in that it is selected from the group consisting of compounds of the general formula :  see diagramm : EP0097071,P21,F1  wherein - X1  and X2 , which may be identical or different each represent H, Cl or F, - Z1  represents CH3 , CH2 CH3 , CH(CH3 )2  or C(CH3 )3 , Z1  may represent the hydrogen atom when at least one of X1 and X2  is different from H, - Z2  represents H ; NZ1 Z2  considered together may represent a piperidino or morpholino group. For the contracting state AT 1. A method for the preparation of a novel benzhydrylsulfinylacetamide derivative of the general formula :  see diagramm : EP0097071,P22,F1  wherein : - X1  and X2  which may be identical or different each represent H, Cl or F, - Z1  represents CH3 , CH2 CH3 , CH(CH3 )2  or C(CH3 )3 , Z1  may represent the hydrogen atom when at least one of X1 and X2  is different from H, - Z2  represents H ; NZ1 Z2  considered together may represent a piperidino or morpholino group, characterized in that an acid chloride of general formula  see diagramm : EP0097071,P22,F2  wherein X1  and X2  are as defined above, is reacted with an amine of general formula HNZ1 Z2 wherein Z1  and Z2  have the above definition, to a benzhydrythiocetamide derivative of general formula  see diagramm : EP0097071,P22,F3  wherein X1 , X2 , Z1  and Z2  are as defined above, and the obtained benzhydrylthiocetamide derivative of formula (IV) is oxidized.
Patent DK-285783-D0 (DK)
Inventor: HEMINGWAY REGINALD GORDON
IPC: A61M31/00
Filed: 1983-06-21
Abstract: The device comprises a core (1) containing nutrient and/or therapeutic material and an insoluble rigid skin (2) enclosing the core (1). The skin (2) is thin and brittle and requires the support of the core to maintain its integrity.For use, prior to introduction of the device in an animal's digestive tract a portion of the skin is removed (3A or 3B and possibly 3C or 3D) (if one end of the core had not been left exposed during manufacture) exposing a portion or portions of the core (1). As the exposed portion dissolves within the animal support is locally removed from the skin (2), the unsupported portion of the skin then disintegrating so that no hindrance is placed in the way of further dissolution of the core.
Patent DK-289988-D0 (DK)
Inventor: MURRAY WILLIAM V
IPC: C07C313/00
Filed: 1988-05-27
Abstract: 2- and 3-substituted (1 min ,5 min -diaryl-3 min -pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.
Patent DK-314485-D0 (DK)
Inventor: ITOH SEIGA
IPC: C12N15/00
Filed: 1985-07-10
Abstract: Disclosed is a novel derivative of human IFN- gamma  polypeptide wherein certain amino acids of human IFN- gamma  polypeptide are removed and certain amino acids other than said amino acids are replaced with other amino acids. The derivatives have high IFN- gamma activity and are expected to be useful as drugs such as anti-viral and anti-tumor agents.
Patent DK-425288-D0 (DK)
Inventor: SCHRINNER ELMAR
IPC: C07D473/06
Filed: 1988-07-29
Abstract: The preparation contains or consists of
 a) at least one sulphated polysaccharide and
 b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.
Patent DK-444888-D0 (DK)
Inventor: DWIVEDI RATNESH K
IPC: C04B35/65
Filed: 1988-08-09
Abstract: A method is provided for producing a self-supporting ceramic composite body having a plurality of spaced apart wall members, each wall member having a bounded cross-section for defining substantially continuous, fluid passageways. The wall members generally inversely replicate in opposed directios the geometry of a positive pattern. Each of the wall members, which are axially aligned, comprises a ceramic matrix having a filler embedded therein, and is obtained by the oxidation reaction of a parent metal to form a polycrystalline material which consists essentially of the oxidation reaction product of the parent metal with an oxidant and, optionally, one or more metals, e.g. nonoxidized constituents of the parent metal.
Patent DK-457885-D0 (DK)
Inventor: LESUER WILLIAM MONROE
IPC: C10M129/95
Filed: 1985-10-08
Abstract: An improvement in known processes for preparing substituted carboxylic acids useful as acylating agents which comprise reacting (A) at least one aliphatic polymer of one or more lower olefins with (B) an acid reactant selected from the group consisting of fumaric acid, itaconic acid, maleic acid, and the corresponding anhydrides, lower alkyl esters, acyl chlorides and acyl bromides, in the presence of chlorine can be improved by the steps of (i) reacting at a temperature of about 100<o>-200<o>C, a mixture of (A) and (B) in the presence of about 0.05 to 0.15 equivalent of chlorine per equivalent of (A) until of the chlorine has reacted to provide a first intermediate product, (ii) continuing the reaction in the absence of chlorine at a temperature of from about 180<o>-250<o>C until a conversion of 0.4 to 1.1 equivalents of (B) per equivalent of (A) is attained to provide a second intermediate product, and (iii) reacting said second intermediate with about 0.2 to 1.5 equivalents of chlorine per equivalent of (A) used in step (i) at a temperature of about 180<o>-225<o>C. The carboxylic acids produced by this improved process can be used, per se, in lubricants and fuels and as acylating agents in reactions with amines, alcohols, reactive metals or reactive metal compounds to form derivative products which are useful, for example, as additives for lubricants and normally liquid fuels.
Patent DK-579489-D0 (DK)
Inventor: PIERACCIOLI DANIELE
IPC: C07D211/90
Filed: 1989-11-17
Abstract: A process for the preparation of compounds of formula (I) <CHEM> in which R1 and R4 independently represent a C1-4 alkyl group, R2 and R3 independently represent a straight or branched C1-6 alkyl chain optionally interrupted by an oxygen atom; and R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group optionally substituted by C1-3 alkyl; which comprises esterification of an acid of formula (II) wherein the groups R1, R2, R3 and R4 have the meanings given above in formula (I) by reaction with an amide acetal capable of introducing the group R5.
Patent DK-691188-D0 (DK)
Inventor: DILCHER DIETMAR
IPC: B60J5/06
Filed: 1988-12-12
Abstract: A hinged sliding door for passenger-conveying vehicles, in particular rail vehicles, whose door leaf (1) can be slid in its longitudinal direction on a guide element (3), the guide element being swivellable transversely to the plane of the door leaf by means of cranks (4, 5) with vertical crankshafts (8, 9). The cranks (4, 5) form, together with this guide element (3) and the door frame (17), a four-bar linkage with opposing cranks. As a result, it is achieved that the door leaf (1) assumes a highly inclined position when the guide element (3) swivels, by means of which position the leading edge of the door leaf is lifted out of the door opening. The cranks (4, 5) are expediently of the same length. In order to coordinate the sliding and swivel movement, the door leaf is guided at its upper and lower end by guide rails (10). 
<IMAGE>
Patent HU-912916-D0 (HU)
Title: Hinge structure for bus with flexible suspension and low undercarriage
Inventor: KRAUSE FRITZ
IPC: B62D47/02
Filed: 1991-09-10
Abstract: In a low-floor articulated omnibus, a central articulated connection (30) is arranged between the front vehicle (1) and the rear vehicle (2). The forces which act on the articulated connection (30) during operation are to be absorbed without risk of damage to the frame or to the mounting on the live ring (12). For this purpose, it is provided that the frames (14, 15) of the front and rear vehicles (1, 2) are elastically mounted on the central articulated connection (30). <IMAGE>
Patent HU-905201-D0 (HU)
Title: Apparatus for separating light liquids
Inventor: HAMMERSCHMITT NIKOLAUS
IPC: B01D17/02
Filed: 1990-06-05
Abstract: PCT No. PCT/DE90/00429 Sec. 371 Date Mar. 27, 1991 Sec. 102(e) Date Mar. 27, 1991 PCT Filed Jun. 5, 1990 PCT Pub. No. WO90/14874 PCT Pub. Date Dec. 13, 1990.The present invention is directed to a light-liquid separator with an inlet for a light liquid/heavy liquid mixture at least one separator chamber for the light liquid from the heavy liquid located behind the inlet, a heavy liquid outlet located behind the separator chamber, an overflow edge being located in front of the heavy liquid outlet, a light liquid outlet including a light liquid balance room, a dip tube extending from a point below the overflow edge of the separator chamber downwardly into the light liquid balance room, and a light liquid discharge tube extending from the light liquid balance room upwardly, as well as a light liquid reservoir with which the light liquid discharge tube is in communication.
Patent NO-870077-D0 (NO)
Inventor: WISSMANN HANS
IPC: C07C67/00
Filed: 1987-01-08
Abstract: The invention relates to new thyronine derivatives of the formula <IMAGE>  (I)  in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R1 and R2 are identical or different and denote iodine or hydrogen, and R3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.