Patent SG-11201811712Q-A (SG)
Title: 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
Inventor: ZHANG LEI
IPC: A61P25/16
Filed: 2017-06-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 MI 11111 0 11101 010 11111 01 110 1 0 011101 1101 010 11111 100 110 11110 MAMIE Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/002760 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C07D 471/04 (2006.01) A61P 25/16 (2006.01) kind of regional protection available): ARIPO (BW, GH, A61K 31/437 (2006.01) A61P 25/18 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, A61P 25/00 (2006.01) A61P 25/28 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (21) International Application Number: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, PCT/IB2017/053565 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 15 June 2017 (15.06.2017) KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: English Declarations under Rule 4.17: (26) Publication Language: English — as to the identity of the inventor (Rule 4.17(i) — as to applicant's entitlement to apply for and be granted a (30) Priority Data: patent (Rule 4.17(ii)) 62/357,624 01 July 2016 (01.07.2016) US — as to the applicant's entitlement to claim the priority of the 62/372,421 09 August 2016 (09.08.2016) US earlier application (Rule 4.17(iii)) (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, Published: New York, NY 10017 (US). — with international search report (Art. 21(3)) (72) Inventors: ZHANG, Lei; 75 Bourne Street, Auburndale, MA 02466 (US). BUTLER, Christopher Ryan; 121 Spring Lane, Canton, MA 02021 (US). BECK, Elizabeth Mary; 27A Botley Road, Oxford, Oxfordshire OX2 OBN (GB). BRODNEY, Michael Aaron; 100 Upland Ave., Newton, MA 02461 (US). BROWN, Matthew Frank; 443 Wheeler Road, Stonington, CT 06378 (US). MCAL- LISTER, Laura Ann; 428 Massachusetts Ave., Apt. 6, Ar- lington, MA 02474 (US). LACHAPELLE, Erik Alphie; 69 Richard Brown Drive, Uncasville, CT 06382 (US). GIL- BERT, Adam Matthew; 178 Denison Drive, Guilford, CT 06437 (US). Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd (74) Street, MS 235/9/S20, New York, NY 10017 (US). Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Il ..! (54) Title: 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGEN- ERATWE DISEASES SO (57) : The present invention provides, in part, compounds of Formula N (R), (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound 0 \ 0 ...„, -.....------Y (R 2 )b 0 \......... or the N- oxide, wherein: R 1 , R 2 , L, A, and E are as described herein; process- --.... 1 \N (I) es for the preparation of; intermediates used in the preparation of; and composi- tions containing such compounds, N-oxides, or salts, and their uses for treating 0 C: N N -----'-1 M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, L—A—E schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.