baber/WOPTO huggingface dataset:
Patent DE-69412534-D1 (DE)
Inventor: YAMAMOTO KENJIRO
IPC: A61K31/4015
Filed: 1994-05-13
Granted: 1998-09-24
Abstract: A compound represented by formula (I): <CHEM> wherein Q represents an aryl group, a heterocyclic group, a diarylmethyl group, an aralkyl group composed of an aryl group and an alkylene group, an alkyl group or a cycloalkyl group, in which the aryl group, heterocyclic group, and the aryl moiety of the diarylmethyl group and aralkyl group may be substituted with one or more substituents; R represents a bicyclic, substituted, nitrogen-containing heterocyclic group or a substituted phenyl group, in which the nitrogen-containing heterocyclic group is composed of a 5-membered, substituted, aromatic or saturated ring containing one or two nitrogen atoms and a 6-membered ring; and Z represents an alkylene group, an alkenylene group, an alkylene group, a carbonyl group, an alkylene group containing a carbonyl group or an oxalyl group, or a salt thereof. The compound has calmodulin inhibitory activity and is useful as a treating agent for diseases in the circulatory organs or in the cerebral region which are caused by excessive activation of calmodulin.
Patent DE-69428521-D1 (DE)
Inventor: MCGREGOR COURTNEY
IPC: A61P31/04
Filed: 1994-02-02
Granted: 2001-11-08
Abstract: Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.
Patent DE-69431050-D1 (DE)
Inventor: MCCABE R TYLER
IPC: A61P25/28
Filed: 1994-04-05
Granted: 2002-08-29
Abstract: Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described. <IMAGE>
Patent DE-69505362-D1 (DE)
Inventor: GASTER LARAMIE
IPC: A61P25/26
Filed: 1995-03-09
Granted: 1998-11-19
Abstract: Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R<1> is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxy C1-6alkoxy, acyl, nitro, trifluoromethyl, cyano, SR<9>, SOR<9>, SO2R<9>, SO2NR<10>R<11>, CO2R<10>, CONR<10>R<11>, CO2NR<10>R<11>, CONR<10>(CH2)pCO2R<11>, (CH2)pNR<10>R<11>, (CH2)pCONR<10>R<11>, (CH2)pCO2C1-6alkyl, NR<10>R<11>, NR<10>CO2R<11>, NR<10>CONR<10>R<11>, CR<10>=NOR<11>, CNR<10>=NOR<11>, where R<10> and R<11> are independently hydrogen or C1-6alkyl and p is 1 to 3; R<2> and R<3> are independently hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-6alkoxy, acyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R<10>, CONR<10>R<11>, NR<10>R<11> where R<10> and R<11> are independently hydrogen or C1-6alkyl; R<4> and R<5> are independently hydrogen or C1-6alkyl; R<6> is hydrogen, halogen, hydroxy, C1-6alkyl or C1-6alkoxy; R<7> and R<8> are independently hydrogen, C1-6alkyl, aralkyl, or together with the nitrogen atom to which they are attached form an optionally substituted 5-7-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, nitrogen or sulphur; A is CONH or NHCO; B is oxygen, S(O)p where p is 0, 1 or 2, or B is NR<12> where R<12 is hydrogen or C>1-6<alkyl; m is 2 to 4; and n is 1 or 2.
Patent DE-69510802-D1 (DE)
Inventor: ITO FUMITAKA
IPC: C07D409/12
Filed: 1995-05-18
Granted: 1999-08-19
Abstract: PCT No. PCT/IB95/00374 Sec. 371 Date Apr. 17, 1997 Sec. 102(e) Date Apr. 17, 1997 PCT Filed May 18, 1995 PCT Pub. No. WO96/06077 PCT Pub. Date Feb. 29, 1996A compound of formula (I):    <IMAGE>  (I)  and its pharmaceutically acceptable salt, wherein R is hydrogen or hydroxy; Ar is unsubstituted or substituted phenyl; X is unsubstituted or substituted phenyl or heterocyclic, mono-, di- or trihalomethyl, cyano, or the like; and X2 is phenyl, naphthyl, furyl, thienyl, pyridyl, thiazolyl, benzofuryl or benzothienyl, each of which may either be unsubstituted or substituted. These compounds have agonist activity toward opioid kappa receptors and are thus useful as analgesic, anti-inflammatory, diuretic and neuroprotective agents.
Patent DE-69512390-D1 (DE)
Inventor: BLASBAND ANDREW
IPC: G01N27/447
Filed: 1995-02-23
Granted: 1999-10-28
Abstract: The present invention is directed to improved side spacers for use in slab gel electrophoresis that prevent the formation of channels between the electrophoresis gel and the side spacer and methods employing the side spacer. The improvement consists of forming the side spacer with one or more notches cut into the edge of the side spacer in contact with the gel, such that, when the gel hardens, the side spacer is anchored into the gel, thereby preventing the formation of channels between the side spacer and the gel.
Patent DE-69512701-D1 (DE)
Inventor: PASQUETTI ORNELLA
IPC: A44C9/00
Filed: 1995-05-18
Granted: 1999-11-18
Abstract: The multiple ring is made up of a number of rings (1-3) which are joined together when worn, e.g. so that diamonds or other stones set in them are aligned symmetrically. All of the rings are hollow, and one of them, e.g. the central ring (1) of three, has an internal spring-loaded coupling (7), held in place by two screws (12) and engaging with hooks (5) projecting into the central ring from the outer ones through slots (6). The coupling is in the form of a curved insert with its two ends fixed by the screws and with its curved section made with supports for a spring wire (14) to engage with the hook(s). The rings can be dismantled by rotating them through 90 degrees relative to one another.
Patent DE-69517191-D1 (DE)
Inventor: IMBERT THIERRY
IPC: A61K31/7042
Filed: 1995-10-20
Granted: 2000-06-29
Abstract: PCT No. PCT/FR95/01388 Sec. 371 Date Apr. 21, 1997 Sec. 102(e) Date Apr. 21, 1997 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/12727 PCT Pub. Date May 2, 1996Water-soluble derivatives of epipodophyllotoxin, process for their preparation and their use for the treatment of rheumatoid arthritis, complaints caused by human papilloma virus and cancer.
Patent DE-69520468-D1 (DE)
Inventor: BASTIOLI CATIA
IPC: C08L3/02
Filed: 1995-08-03
Granted: 2001-05-03
Abstract: Biodegradable foamed articles having density comprised from 5 to 300 kg/m³ obtained by agglomeration of foamed particles having composition comprising a thermoplastic starchy material or a thermoplastic natural polymer capable of absorbing water when converted into the thermoplastic state, a thermoplastic polymer, and water.
Patent DE-69527202-D1 (DE)
Inventor: GAJEWCZYK M
IPC: A61K39/39
Filed: 1995-06-08
Granted: 2002-08-01
Abstract: A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.
Patent DE-69601336-D1 (DE)
Inventor: RATTINK WILLEM MARINUS
IPC: E05D15/06
Filed: 1996-09-09
Granted: 1999-02-25
Abstract: A process for manufacturing a cantilever gate, which gate (1) comprises a supporting beam (3) and an upper structure (4) mounted on the supporting beam (3), which supporting beam (3) is brought into a bent state before the mounting of the upper structure (4). The resulting curve is fixed by means of at least one stiffening member (14,15) rigidly connected with the supporting beam (3) over a substantial part of the length of the supporting beam (3). The supporting beam (3) is then completed to a cantilever gate (1) of which the upper structure (4) is mounted on the concave side of the curved supporting beam (3). The supporting beam (3) has a tubular section with longitudinal flanges between which a stiffening member (14,15) can be arranged.
Patent DE-69601804-D1 (DE)
Inventor: TERRONI SERGE
IPC: C22F1/04
Filed: 1996-08-29
Granted: 1999-04-22
Abstract: The invention relates to a method for improving the reflectivity of an aluminium or aluminium alloy sheet or web. It comprises the irradiation of the surface of the sheet or web by means of a ray emitted by an excimer laser, in an homogeneous way on the treated surface and perpendicularly to the latter, with one or a plurality of pulses having an energy density comprised between 2 and 8 J/cm<2> (for a wavelength of a laser beam of 308 nm). The mean roughness of the surface is reduced by at least 50 % and the reflectivity is increased by at least 25 %.
Patent DE-69604669-D1 (DE)
Inventor: FLEURY ANNETTE
IPC: G07F11/68
Filed: 1996-07-15
Granted: 1999-11-18
Abstract: An apparatus for automatically dispensing a sheet material from a supply roll of gift-wrapping paper, comprising means for supporting the roll from which a sheet may be unrolled, sheet feeding means and means for cutting the unrolled sheet. The apparatus further includes means for rewinding the unrolled sheet, said means being arranged to enable each cut sheet to be rolled into an output roll having a selected length.
Patent DE-69604852-D1 (DE)
Inventor: HERBELIN JEAN-MARC
IPC: C22C38/28
Filed: 1996-03-25
Granted: 1999-12-02
Abstract: A ferritic steel alloy, used as a catalyst support in a car exhaust filter, comprises 12-25% Cr, 4-7% Al, less than 0.08% in total of one or more of Ce, La, Nd, Pr and Y, pref. less than 0.3% in total of Zr and/or Nb and less than the following of other constituents 0.03% C, 0.02% N, 0.22% Ni, 0.002% S, 0.6% Si and 0.4% Mn. The actual amounts of Zr and/or Nb are defined mathematically in terms of the C and N levels.
Patent DE-69609099-D1 (DE)
Inventor: MORIYA TAKEHIRO
IPC: G10L19/038
Filed: 1996-03-07
Granted: 2000-08-10
Abstract: In a CELP coding scheme, p-order LPC coefficients of an input signal are transformed into n-order LPC cepctrum coefficients cj (S2), which are modified into n-order modified LPC cepstrum coefficients cj' (S3). Log power spectral envelopes of the input signal and a masking function suited thereto are calculated (Figs. 3B, C), then they are subjected to inverse Fourier transform to obtain n-order LPC cepstrum coefficients, respectively, (Figs. 3D, E), then the relationship between each corresponding orders of the both LPC cepstrum coefficients is calculated, and the modification in step S3 is carried out on the basis of the relationship. The modified coefficients cj are inversely transformed by the method of least squares into m-order LPC coefficients for use as filter coefficients of a perceptual weighting filter. This concept is applicable to a postfilter as well. <IMAGE>
Patent DE-69609848-D1 (DE)
Inventor: POSCHENRIEDER L
IPC: H01L21/027
Filed: 1996-09-03
Granted: 2000-09-21
Abstract: A system and method of avoiding pattern shortening without resorting to generating a mask with a bias solve the direction dependent differences in exposure behavior in photolithography processes in the manufacture of semiconductor devices. Instead of designing a biased mask to solve the exposure problem, the pattern shortening effect is avoided by influencing the exposure process itself. By using an off axis illumination technique, the exposure is separated into different directions. In one embodiment, off axis illumination is applied in combination with special dipole apertures (i.e., two openings). The exposure is done in two or more parts, whereby the aperture is twisted between exposures. In another embodiment, off axis illumination is used in combination with special polarizer apertures. As with the first embodiment, the exposure is done in two or more parts, but in this case with differently polarized light.
Patent DE-69614813-D1 (DE)
Inventor: GUEGNAUD HERVE
IPC: H03D7/18
Filed: 1996-12-12
Granted: 2001-10-04
Abstract: The mixer receives a first input signal (X) which is mixed (12,14) with signals at a frequency f0, from a local oscillator. A second input signal is mixed with signals (X1,X2) in quadrature with the LO signals. A summer (22) produces a sum (X3) of the first (X1) and second (X2) quadrature signals and a phase-shifting filter (24) with a transfer function A(f) produces a signal (X3') which provides a delay of 45 degrees at the intermediate frequency, f1. A transfer function B(f) is applied to either the first or second signal to generate a fourth signal (X4). The ratio A(f1)/B(f1) has a modulus equal to the inverse square root of 2 and an argument equal to plus or minus 45 degrees or plus or minus 135 degrees . A second summer (18) produces an output (Y) at the intermediate frequency with a phase representative of the input signal at a communication frequency (fo+ f1) or (f0-f1).
Patent DE-69618356-D1 (DE)
Inventor: LILJEVALL HANS
IPC: G07B1/00
Filed: 1996-05-02
Granted: 2002-02-07
Abstract: An apparatus for selectable processing of an information carrier in the form of a sheet or in the form of a strip, comprising: a housing (2); guide track members (1, 3) mounted in the housing (2) for delimiting a first guide track and a second guide track designed for controlling an information carrier. The apparatus according to the invention is characterized in that the guide track members (5) delimit a processing track (8) which is open or can be opened in the guide direction and which is designed for selectable processing of an information carrier in the form of a sheet of undefined length and in the form of a strip of undefined length.
Patent DE-69623282-D1 (DE)
Inventor: CAMILLUS C
IPC: G06K15/12
Filed: 1996-06-03
Granted: 2002-10-02
Abstract: A printer (10) housed in an accessible drive bay of a computer. The computer including media access (12) for inserting media to be printed into the printer, a communication link for receiving image data, a printhead for printing on the media, and means for mounting the printer in the bay. Also, a personal computer includes a housing, an accessible drive bay in the housing, a central processing unit, memory, a data retrieval and storage device, at least one connection for an input/output device, a power supply, and a printer, wherein the printer is housed within the drive bay.
Patent DE-69624137-D1 (DE)
Inventor: KONDO TOMOYUKI
IPC: C09K19/40
Filed: 1996-07-26
Granted: 2002-11-07
Abstract: An object of the present invention is to provide organosilicon compounds having an excellent miscibility with other liquid crystal materials, low viscosity, and improved threshold voltage; to provide liquid crystal compositions comprising the organosilicon compound; and to provide liquid crystal display devices comprising the liquid crystal composition. The organosilicon compounds are expressed by the general formula (1) <CHEM> wherein at least one of Ra, Rb, Z1, Z2, and Z3 has -SiH2-; Ra represents hydrogen atom or an alkyl grouop having 1 to 20 carbon atoms; at least one -CH2- in the alkyl group may be replaced by -SiH2-, -O-, -S-, -CO-, -CH=CH-, -C IDENTICAL C-, or 1,3-cyclobutylene; Rb represents a group selected from Ra, a halogen atom, or CN; each of A, A1, A2, and A3 represents a divalent cyclic group; Z1, Z2 and Z3 independently represent a covalent bond or -(CH2)p-; at least one -CH2- in the (CH2)p- may be replaced by -SiH2-, -O-, -S-, -CO-, -CH=CH-, or -C IDENTICAL C-; p is an integer of 1 to 4; and m, n, and o are independently 0 or 1.
Patent DE-69624365-D1 (DE)
Inventor: OSHIMA MASAHIRO
IPC: A61K38/00
Filed: 1996-07-19
Granted: 2002-11-21
Abstract: Compounds represented by the general formula (I) wherein n represents 1 or 2; R<1> represents, for example, a C1-C10 alkyl group which may be substituted with a C3-C10 cycloalkyl group or carboxyl group; R<2> represents hydrogen atom, a C1-C10 alkyl group or other; and R<3> represents amino group or amidino group, whose example include trans-4-amino-Ä(S)-N-Ä(S)-2-propoxycarbonylamino-3-isopropylthio-3-met hyl-butanoylÜprolylÜaminomethylcyclohexane The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants. <CHEM>
Patent DE-69632466-D1 (DE)
Inventor: CHOMCZYNSKI PIOTR
IPC: C07K1/00
Filed: 1996-07-18
Granted: 2004-06-17
Abstract: Solutions and methods are disclosed for the effective, simple isolation/extraction of DNA, RNA and proteins from a single biological material sample, such as cells, tissues and biological fluids. The preferred solutions include effective amounts of a chaotropic agent(s), buffer, reducing agent, and may or may not include an organic solvent. Genomic DNA and total RNA can be isolated utilizing the solutions and methods of the invention in as little as 20 minutes, and proteins in as little as 30 minutes.
Patent DE-69637723-D1 (DE)
Inventor: SAMULSKI RICHARD J
IPC: C12P21/02
Filed: 1996-05-14
Granted: 2008-12-04
Abstract: The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated viral (AAV) capsid proteins. The invention provides an means of obtaining recombinant viral stocks that may be used to treat patients suffering from genetic diseases.
Patent DE-69722226-D1 (DE)
Inventor: GUSTAVSSON SOEREN
IPC: D21C3/00
Filed: 1997-09-25
Granted: 2003-06-26
Abstract: The invention relates to a process for producing chemical pulp from comminuted cellulose-containing material without using sulphur-containing cooking liquids, thereby removing the problems, for example smell problems, which are associated with sulphur-containing liquids. The process comprises at least one impregnation stage followed by at least one cooking stage, with a delignification-accelerating compound being supplied to at least one of the said stages. In the process, a first cooking liquid, which has been extracted from a position downstream of the impregnation stage, which liquid primarily contains OH<-> ions as the active substance, is supplied to the impregnation stage. This makes it possible to achieve a higher concentration of OH<-> ions than in the case of conventional soda-anthraquinone cooking and to use a lower process temperature. The process is suitable for producing chemical pulp from essentially all generally available raw materials for cellulose production and also for producing pulp from non-Scandinavian raw materials as well as for producing pulp from alternative fibrous raw materials. The process is suitable both for producing pulp which is intended for ECF bleaching or TCF bleaching and for producing unbleached high-yield pulp.
Patent DE-69724608-D1 (DE)
Inventor: ROBINSON NEIL
IPC: H04W40/02
Filed: 1997-04-10
Granted: 2003-10-09
Abstract: The traffic load between a busy cell and adjacent cells with spare capacity is optimized by allocating the transmission of delay unconstrained packet data, such as e-mail, to an adjacent cell. To maintain C/I ratio for the call, the transmitting terminal increases the energy per bit by, for example, reducing modulation rate (ie data rate), using modulation with fewer levels (such as 16 QAM to QPSK), increasing FEC overhead and/or spectrum spreading factor (increased redundancy), or increasing the interleaving depth (spreading interference more widely). As the nominal edge of cell will have been effectively extended, the mobile terminals transmitting data may be closer than normal to a remote cell which is re-using the same frequency. The terminal transmitting data therefore maintains or reduces power to avoid co-channel interference. Reducing power requires the addition of still further reduction in data rate in order to maintain the required energy per bit/symbol at the serving base station.
Patent DE-69732230-D1 (DE)
Inventor: AONO KATSUTOSHI
IPC: C07D233/84
Filed: 1997-03-14
Granted: 2005-02-17
Abstract: A compound of the formula (I): <CHEM>  wherein X, Y, Z and R are as defined above, salt thereof, or hydrate thereof which effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high concentration is provided.
Patent DE-69738830-D1 (DE)
Inventor: SEIDEL RANDY R
IPC: B65H29/18
Filed: 1997-04-14
Granted: 2008-08-21
Abstract: The present invention relates to a transfer device for successively feeding a plurality of generally planar elements (40) to a receiver (23).
Patent DE-69804640-D1 (DE)
Inventor: TEMPLE STEPHEN
IPC: H04N1/034
Filed: 1998-09-07
Granted: 2002-05-08
Abstract: A drop-on-demand multi-tone printing apparatus has a series of channels arranged to receive ink from a source. Each channel has a respective ink outlet. Each adjacent pair of the channels is separated by a respective dividing wall, and each dividing wall is movable in response to a respective pulsed electrical signal to apply pressure pulses to the respective pair of the channels, whereby ink can be ejected from the outlets and deposited onto a recording medium. A respective pulsed electrical signal is developed for each channel in dependence upon whether ink is to be ejected from that channel, the signals for adjacent pairs of the channels temporally overlapping each other and not being in phase with each other.
Patent DE-69805213-D1 (DE)
Inventor: UBINANA FELIX JOSE LUIS
IPC: E04G25/06
Filed: 1998-01-12
Granted: 2002-06-13
Abstract: The outer and inner tubes (1,2) of a telescopic prop are connected by a thread (17) engaged to an outer adjustment nut (3) with handles (26,27). A sliding sleeve (15) on the upper tube (2) bears on the collar (25) of the nut (3) and includes diametrically opposite notches (5) with intermediate inclined steps (9). An axial travel limit pin (10) through the upper tube rests on the inclined steps when the prop is extended and load carrying. In this situation the notches (8) are closed by tongues (12) on a sliding collar (11). For quick release, the collar is lifted by a handle (14) and the sleeve tapped round to allow the pin to drop into the notches.
Patent DE-69809930-D1 (DE)
Inventor: GURE O
IPC: C12N15/12
Filed: 1998-02-25
Granted: 2003-01-16
Abstract: The invention relates to members of the SSX family of genes, as well as their uses.
Patent DE-69810579-D1 (DE)
Inventor: TSUCHIYA OSAMU
IPC: C21B13/10
Filed: 1998-10-30
Granted: 2003-02-13
Abstract: A method for producing an iron oxide pellet including the steps of adding water to a raw material mixture comprising iron oxide which serves as a primary component, a carbonaceous material in an amount sufficient for reducing the iron oxide, an organic binder (e.g. wheat flour) in an amount sufficient for binding the iron oxide and the carbonaceous material, and an inorganic coagulant (bentonite) in an amount of not less than 0.05 mass% and less than 1 mass%; pelletizing the resultant mixture to thereby obtain a green pellet; and drying the green pellet until the moisture content is reduced to equal to or less than 1.0 mass%. The thus-produced iron oxide pellet is charged in a (rotary hearth) reducing furnace for reduction to thereby obtain a reduced iron pellet.
Patent DE-69811911-D1 (DE)
Inventor: MACKEY JACK
IPC: F25C3/04
Filed: 1998-08-17
Granted: 2003-04-10
Abstract: A moldable composition and method of making the same, the composition including a binding mixture and filler in the form of crystalline, irregular, approximately polygonally shaped particles. The binding mixture preferably includes polyvinyl-based binders such as polyvinyl alcohol, water, a cross-linking agent such as borax, and a humectant such as propylene glycol. Furthermore, a cellulose-based thickener may be added to the binding mixture, as may a pH-adjusting compound such as sodium carbonate. The crystalline particles preferably are ground styrene having a maximum dimension ranging from one-half to three millimeters.