Patent SG-11201806945S-A (SG)
Title: Cancer epigenetic profiling
Inventor: TAN PATRICK
IPC: C12Q1/68
Filed: 2017-02-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101111101011111111111101111101111011111 International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/142485 Al 24 August 2017 (24.08.2017) WI P0 I P CT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C12Q 1/68 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/SG2017/050073 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 16 February 2017 (16.02.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 10201601141X 16 February 2016 (16.02.2016) SG kind of regional protection available): ARIPO (BW, GH, 10201606828P 16 August 2016 (16.08.2016) SG GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: AGENCY FOR SCIENCE, TECHNOLOGY TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Connexis North Tower, Singapore 138632 (SG). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, (72) Inventors: TAN, Patrick; c/o Genome Institute of Singa- pore, 60 Biopolis Street, Genome, #02-01, Singapore GW, KM, ML, MR, NE, SN, TD, TG). 138672 (SG). 001, Wen Fong; c/o Genome Institute of Declarations under Rule 4.17: _ Singapore, 60 Biopolis Street Genome, #02-01, Singapore — of inventorship (Rule 4.17(N)) 138672 (SG). Published: (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; — international 21(3)) = P.O. Box 1531, Robinson Road Post Office, Singapore with search report (Art. 903031 (SG). — with sequence listing part of description (Rule 5.2(a)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, = = = = = = = = = = = 1-1 kin cc ii- ei - ii 1-1 (54) Title: CANCER EPIGENETIC PROFILING I N (57) : The present invention relates to a method for determining the presence or absence of at least one super-enhancer in a 1-1 C cancerous biological sample based on signal intensity of the histone modification H3K27ac. The present invention also relates to a N method for determining the prognosis of cancer in a subject, a method of determining the susceptibility of a subject to cancer or a O gastrointestinal disease and a method of predicting cancer cell survival or cancer cell viability by determining the presence or ab - ,..1: sence of at least one super-enhancer. The present invention also relates to inhibitors of CDX2 and/or HNF4a, such as metformin, and use thereof for modulating the activity of a super-enhancer.