baber/WOPTO huggingface dataset:
Patent DE-69530283-T2 (DE)
Inventor: HOFMANN GUNTER A
IPC: A61M31/00
Filed: 1995-01-20
Granted: 2004-01-29
Abstract: A catheter device having a plurality of axially extending, circumferentially spaced electrodes carried thereby, infusion means for infusion of fluid medium for carrying genes and drugs, and expandable sealing means at each end of the electrodes for sealing off and confining the therapeutic medium to the area to be treated is inserted into a selected blood vessel of a patient and advanced to a preselected location within the blood vessel where cells on or near the wall of the vessel are to be treated. Once in place, the catheter device is expanded so that the plurality of axially extending, circumferentially spaced electrodes carried thereby are in contact with the inner wall of the blood vessel and seals at each end of the electrodes expand and seal the catheter device in the preselected location. A quantity of therapeutic genes or drugs is infused into the area of the electrodes via a tube and a conventional pump. A power pack connected to the electrodes is energized subjecting the cells to electric fields of predetermined amplitude and duration making the walls of the cells transiently permeable to enabling therapeutic genes or drugs carried by the fluid medium to enter the cells without killing them.
Patent DE-69532968-T2 (DE)
Inventor: FOSTER C
IPC: C12R1/865
Filed: 1995-11-15
Granted: 2004-10-21
Abstract: DNA constructs useful in the production of thrombopoietin are disclosed. In general, the DNA constructs comprise a first DNA segment encoding a fusion of an amino-terminal secretory peptide joined to a thrombopoietin polypeptide and one or more additional DNA segments that provide for the transcription of the first segment. The secretory peptide is a native mammalian t-PA secretory peptide or may be modified to enhance proteolytic cleavage of the fusion. Also disclosed are cultured eukaryotic cells containing these DNA constructs and methods for producing thrombopoietin polypeptides through the use of the DNA constructs and cultured eukaryotic cells.
Patent DE-69608000-T2 (DE)
Inventor: BOUSQUET JEAN-CLAUDE
IPC: B65D90/14
Filed: 1996-01-26
Granted: 2000-12-21
Abstract: A removable carriage (10) comprises a horizontal chassis (2) with two guide wheel (3) mounted under it. The wheels are connected by two vertical rotating shafts located in two transversely separated positions with a vertical pivot (4) mounted between them. A coupling synchronises rotation of the vertical shafts on the pivot. A steering shaft (6) which is pivoted about a horizontal trunnion (26) can be temporarily locked in a given configuration on the pivot. A transverse vertical panel (8) which slides vertically in the chassis front has a vertical actuator (9) interposed between panel top (43) and the chassis lower part (41). Two coupling fingers (10) are pivoted to the front panel about horizontal coaxial transverse trunnions. Removable locks lock these fingers in each of two different configurations of inclination about these trunnions. Two coupling fixed to the end of the load simultaneously engage the fingers in one of their working configurations.
Patent DE-69628408-T2 (DE)
Inventor: OWEN RONALD
IPC: A61L31/04
Filed: 1996-01-19
Granted: 2004-03-11
Abstract: A method for joining tissue comprising aligning and abutting edges of the tissue to be joined applying a biodegradable, biological solder or an analogue thereof, across the edges and exposing the solder to an energy source under conditions which provide transfer of energy from the source to the solder to cause the solder to bond to the tissue surface adjacent the edges to provide a weld holding the edges together.
Patent DE-69629367-T2 (DE)
Inventor: MEINGASSNER GOTTFRIED
IPC: A61P31/04
Filed: 1996-05-10
Granted: 2004-06-09
Abstract: PCT No. PCT/EP96/02022 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed May 10, 1996 PCT Pub. No. WO96/35423 PCT Pub. Date Nov. 14, 1996Use of a combination of the squalene epoxidase inhibitor terbinafine and an azole 14-alpha-methyldemethylase inhibitor (fluconazole or itraconazole) in mycotic infections caused by azole-resistant fungal strains, and corresponding pharmaceutical compositions, process and method.
Patent DE-69634259-T2 (DE)
Inventor: PAN PAULINE
IPC: A61K/
Filed: 1996-10-10
Granted: 2006-01-19
Abstract: An antimicrobial composition containing an alcohol having 3 to 6 carbon atoms which effectively increases antimicrobial activity and particularly a mouthwash composition that is useful in the prevention and reduction of bad breath, plaque and related gum diseases having an antimicrobially effective amount of one or more active essential oils; from about 0.01 % to about 30.0 % v/v of an alcohol having 3 to 6 carbon atoms; optionally, ethanol; at least one surfactant; and water. The actives not only provide enhanced efficacy but are completely solubilized, thus providing an aesthetically appealing product.
Patent DE-69700744-T2 (DE)
Inventor: DITTRICH DAVID
IPC: A24D3/10
Filed: 1997-01-08
Granted: 2000-04-27
Abstract: A cigarette is provided with a filter comprising a filter element of water-disintegratable paper. The paper is water swellable and/or the filter element comprises a water swellable agent. Tipping which interattaches the filter to the tobacco rod of the cigarette is anchored by means of water susceptible adhesive. Thus when the cigarette comes into contact with sufficient water, the filter element swells and the tipping opens away from the filter. This facilitates disintegration of the water-disintegratable paper.
Patent DE-69701791-T2 (DE)
Inventor: ROLLE JEAN-CLAUDE
IPC: C08J9/04
Filed: 1997-01-31
Granted: 2000-12-28
Abstract: The invention relates to a thermoformable sheeting consisting of a foam material or containing at least one layer of a foam material. The inventive sheeting is particularly applicable for thermoforming cups or trays for packaging and/or consuming food stuffs, by drawing or deep drawing the sheeting and expanding the foam material. The foam material of the inventive sheeting consists of a polypropylene blend containing between 50 and 100% of high melt strength polypropylene, has a density of 0.1 to 0.7 g/cm3, preferably between 0.25 and 0.5 g/cm3, and a cell number of from greater than 300 to 3000 cells per mm3, preferably between 800 and 2500 cells per mm3. The inventive sheeting can be drawn with a high drawing ration (e.g. 1.5) and expanded to be formed into containers even with difficult shapes, whereby no drawing problems arise and the containers produced show a homogeneous opaqueness.
Patent DE-69708830-T2 (DE)
Inventor: DUBIEF CLAUDE
IPC: A61K8/68
Filed: 1997-12-05
Granted: 2002-04-18
Abstract: Cosmetic hair composition comprises a ceramide type compound (I) and at least one UV filter (II) which contains at least one sulphonic acid group. (II) is preferably a 2-benzylidene-2-camphor compound (preferably 2-phenylbenzimidazole-5-sulphonic acid, benzene-1,4-di(benzamidazol-2-yl) 5-sulphonic acid or benzene 1,4-di(benzoxazol-2-yl)-5-sulphonic acid) and (I) is preferably 2-N-linoleoylamino-octadecane-1,3-diol, 2-N-oleoylamino-octadecane-1,3-diol, 2-N-palmitoylamino-octadecane-1,3-diol, 2-N-stearoylamino-octadecane-1,3-diol, 2-N-behenoylamino-octadecane-1,3-diol, 2-N-Ä2-hydroxypalmitoylÜamino-octadecane-1,3-diol, 2-N-stearoylamino-octadecane-1,3,4-triol and/or 2-N-palmitoylamino-hexadecane-1,3-diol or bis-(N-hydroxyethyl-N-cetyl)malonamide, N-(2-hydroxyethyl)-N-(3-cetyloxy-2-hydroxypropyl) amide of cetyl alcohol or N-docosanoyl-N-methyl-D-glucamine).
Patent DE-69712108-T2 (DE)
Inventor: ILLUM LISBETH
IPC: A61K47/48
Filed: 1997-07-10
Granted: 2002-12-12
Abstract: A composition comprising biodegradable microspheres that act as carriers for the delivery of DNA to the endothelial cells of a vascular bed, wherein the microspheres carry a net negative charge and to which is adsorbed positively charged particles of a smaller size, wherein such positively charged particles comprise a conjugate of DNA and a cationic compacting agent.
Patent DE-69712635-T2 (DE)
Inventor: NACHENBERG S
IPC: G06F21/00
Filed: 1997-11-17
Granted: 2003-01-30
Abstract: A computer-implemented method for executing a computer file in a CPU emulator (154) to detect a computer virus. The method includes simulating (302) the execution of a predetermined number of instructions of the computer file in the CPU emulator (154), suspending (303) the execution, constructing (304) a state record, temporarily storing (305) the state record in memory, comparing (306) the constructed state record to state records stored in a state cache (158), and indicating (308) that the file is virus free when the constructed state record matches one of the stored state records.
Patent DE-69718612-T2 (DE)
Inventor: SENE CLAUDE
IPC: A61K35/76
Filed: 1997-07-15
Granted: 2003-11-06
Abstract: The present invention provides a novel method for preserving infectious recombinant viruses in frozen or liquid form, in which infectious viruses are preserved in an aqueous solution. The recombinant virus suspension comprises an aqueous sucrose solution at a concentration of 0.75 M or above, preferably between 0.75 M and 1.5 M, or more preferably at a concentration of 1 M. The preserved aqueous viral suspension further provides a medicament that can be used therapeutically or prophylactically for the treatment of a human or animal body by gene therapy.
Patent DE-69719801-T2 (DE)
Inventor: HULTMARK GOERAN
IPC: F24J2/48
Filed: 1997-09-15
Granted: 2003-12-18
Abstract: A spectral selective absorbing surface on solar collector elements has a very high solar absorbing ability, in the range of 96% to 97% and a low thermal emittance, in the order of 10%, and can be produced with high capacity in industrial scale. A reactive gas in an amount of 1 to 50 cm 3/min kW, preferably 10 cm 3/min kW, distributed in the coating zone provides that the metal layer deposed onto the receiving material partly oxidizes during the deposition, whereby a layer is obtained that comprises a grain mixture of metallic material and metal oxide, whereby 40% to 80%, preferably about 50%, of metallic material is embedded into the metal oxide closest to the receiving material. The metallic material is successively decreased to about zero at the surface of the layer by increasing the addition of oxygen at the end of the coating zone. The metal is selected from the group consisting of nickel, chromium, cobalt, molybdenum, or the similar, or a mixture thereof, preferably a nickel-chromium-alloy where the ratio of chromium is 4 to 30%, preferably about 20%, and the grain size is <0.005 mm, preferably 0.001 mm.
Patent DE-69730335-T2 (DE)
Inventor: WANG YAO-TING
IPC: G03F1/00
Filed: 1997-09-18
Granted: 2004-12-30
Abstract: A method and apparatus for creating a phase shifting mask and a structure mask for shrinking integrated circuit designs. One embodiment of the invention includes using a two mask process. The first mask is a phase shift mask and the second mask is a single phase structure mask. The phase shift mask primarily defines regions requiring phase shifting. The single phase structure mask primarily defines regions not requiring phase shifting. The single phase structure mask also prevents the erasure of the phase shifting regions and prevents the creation of undesirable artifact regions that would otherwise be created by the phase shift mask. Both masks are derived from a set of masks used in a larger minimum dimension process technology.
Patent DE-69733432-T2 (DE)
Inventor: WU JING
IPC: C07D213/40
Filed: 1997-11-21
Granted: 2006-05-04
Abstract: Disclosed are compounds which inhibit  beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits  beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.
Patent DE-69803271-T2 (DE)
Inventor: BERNARDON JEAN-MICHEL
IPC: A61K8/00
Filed: 1998-08-21
Granted: 2002-08-08
Abstract: Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R<SUB>2 </SUB>and R<SUB>3 </SUB>represent, in particular, H or alkyl, or R<SUB>2 </SUB>and R<SUB>3</SUB>, taken together, form a 5- or 6-membered ring, R<SUB>4 </SUB>and R<SUB>5 </SUB>represent, in particular, H or halogen, R<SUB>6 </SUB>represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.
Patent DE-69806890-T2 (DE)
Inventor: FELDMAN MOSHE
IPC: A01H1/04
Filed: 1998-05-14
Granted: 2003-03-27
Abstract: The present invention provides a method for the production of hybrid wheat based on the ability to stably maintaining a genic male-sterile female parental line of common and durum wheat It also provides a male-sterile female line homozygous for a recessive male-sterility allele and for a dominant pollen-killing allele, and a maintainer line which is readily and stably propagated. The maintainer line is isogenic to the female line but has an alien engineered chromosome carrying a dominant male-fertility allele that restores fertility to the maintainer line, a recessive pollen-killing allele that is susceptible to the killing effect of the native pollen killer thus preventing transmission of this chromosome to the female line, and one or more selectable markers that facilitate the maintenance of the maintainer itself. The invention also provides procedures for converting any desired cultivar into male-sterile female line and into a maintainer line.
Patent DE-69814343-T2 (DE)
Inventor: PAGEAT PATRICK
IPC: A61K35/24
Filed: 1998-01-21
Granted: 2003-12-24
Abstract: A composition comprising a mixture of fatty acids such as linoleic, oleic and palmitic acids or derivatives thereof derived from secretions of mammalian mammary glands. This composition can be utilized to decrease stress, anxiety and aggressiveness in mammals.
Patent DE-69827042-T2 (DE)
Inventor: VILLA MARCO
IPC: C07D249/08
Filed: 1998-11-20
Granted: 2005-12-01
Abstract: Process for the preparation of a compound of formula (VII) wherein R1 is Cl, F or CF3; R2 is H, Cl, F or CF3; and R3 is C1-4 alkyl; characterized in that an olefin of formula (II) is epoxidized to give an oxirane of formula (III) which treated with alkyl-magnesium halide gives a triol of formula (IV) which is turned into an epoxide of formula (V), then treated with 1,2,4-triazole. The compounds (VII) are useful for preparing azole derivatives active as antifungal agent.
Patent DE-69827676-T2 (DE)
Inventor: WILSON A
IPC: B01D53/04
Filed: 1998-10-26
Granted: 2005-12-08
Abstract: An electrically regenerable gas filter system includes a carbon fiber composite molecular sieve (CFCMS) filter medium (7) for separation and purification, or catalytic processing of fluids. Filter medium (7) is made of carbon fibers rigidly bonded to form an open, permeable, rigid monolith capable of being formed to near-net-shape. A separate medium-efficiency pre-filter (5) removes particulate from a supply airstream before the airstream passes through the CFCMS filter (7) to sorb gaseous air polutants. The airstream is then recirculated to a space. When saturated, CFCMS media (7) is regenerated utilizing a low-voltage current from power supply (22) that is caused to pass through filter media (7).
Patent DE-69832375-T2 (DE)
Inventor: PRICHARD K
IPC: A61K31/475
Filed: 1998-04-29
Granted: 2006-06-01
Abstract: This invention describes methods for increasing the toxicity of a cytostatic hydrophobic chemotherapeutic agent against resistant tumor cells in mammals which comprise administering a multidrug resistant reversing agent to the mammal in connection with the administration of the cytostatic hydrophobic chemotherapeutic agent in an amount effective to increase the toxicity of the chemotherapeutic agent, wherein the multidrug resistant reversing agent is a macrocyclic lactone compound. Examples of the macrocyclic lactone compounds useful in the present invention include, but are not limited to, the LL-F28249 alpha - lambda  series of compounds, the 23-oxo or 23-imino derivative thereof, the avermectins, the 22,23-dihydro derivatives thereof and the milbemycins. Compositions comprising the macrocyclic lactone compounds and the chemotherapeutic agents are also described herein.
Patent DE-69837719-T2 (DE)
Inventor: SVANBORG CATHARINA
IPC: A61K38/00
Filed: 1998-11-23
Granted: 2008-01-31
Abstract: A method for producing an oligomeric form of alpha-lactalbumin which is in the molten globule-like state is described. The method suitably comprises exposing a source of alpha-lactalbumin in which the alpha-lactalbumin is preferably in the molten globule-like state, to an ion exchange medium which has been pre-treated with casein or an active component thereof, such as oleic acid, and recovering alpha-lactalbumin in an oligomeric form therefrom. Pre-treatment of the ion exchange medium, particularly with casein derived from human milk, has been found to significantly improve yields of the oligomeric form of alpha-lactalbumin and mean that it can readily isolated from readily available sources such as bovine alpha-lactalbumin. This form of alpha-lactalbumin is useful therapeutically, in particular as an antibacterial agent and also as an anti-cancer therapeutic.
Patent DE-69902249-T2 (DE)
Inventor: WRIGHT DOMINIC
IPC: C22C1/04
Filed: 1999-04-08
Granted: 2003-02-27
Abstract: Disclosed is a process for the production of Zintl compounds by thermal decomposition of heterometallic phosphinidene complexes. The heterometallic phosphinidene complex typically comprises at least two metals, at least one of which is selected from a Group I metal, M1, and another being a metal M2, selected from Group 13, 14 or 15 of the Periodic Table. The heterometallic phosphinidene complex further comprises one or more phosphinidene ligands, [PR], wherein R is typically a substituted or unsubstituted hydrocarbyl group, and a Lewis base stabilizing ligand. Thermal decomposition of the heterometallic phosphinidene complexes in accordance with the invention forms a Zintl compound comprising metals M1 and M2 coordinated to Lewis base stabilizing ligands, Lg. The invention further provides a process for removal of the stabilizing ligand from the Zintl compounds to form an intermetallic compound. Intermetallic compounds having photoactive characteristics may be formed by this process, and are useful in the production of photoactive layers in electronic devices.
Patent DE-69903725-T2 (DE)
Inventor: GUIDOROSSI ACHILLE
IPC: E02F9/20
Filed: 1999-06-09
Granted: 2003-06-12
Abstract: A duplicate layout of sets (11-12) of control levers of a distributor (10) of hydraulic equipment for trucks, particularly hydraulic cranes, wherein a direct control set (11) is provided with levers (110a-e) whose respective arms are axially aligned with first forks (13'a-e) for the articulation of the ends of corresponding transmission rods (14a-e) and the other duplicate control set (12) is provided with levers (120a-e) whose arms are axially offset with respect to second forks (13''a-e) for the articulation of the other ends of the transmission rods (14a-e), each one of the axially offset arms being connected to the corresponding second forks (13''a-e) by means of its own arm portion (121a-e) which is folded substantially at right angles and runs parallel to the axis of the pivoting shaft (15) of the second articulation forks (13''a-e).
Patent DE-69903945-T2 (DE)
Inventor: PAVESIO ALESSANDRA
IPC: D04H1/42
Filed: 1999-05-25
Granted: 2003-07-17
Abstract: Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
Patent DE-69907673-T2 (DE)
Inventor: LUDTKE A
IPC: H04N5/445
Filed: 1999-06-15
Granted: 2004-03-25
Abstract: On-screen-display graphics data is transmitted from a source device to a display device over an IEEE 1394-1995 serial bus network utilizing an isochronous data format. The on-screen-display graphics data is generated by the source device and transmitted to a display device, as a stream of isochronous data, separate from video data. Each packet of isochronous data within the stream of on-screen-display graphics data includes an address value corresponding to a memory address within the display device forming a buffer. When received by the display device the on-screen-display graphics data is loaded into the appropriate memory locations within the buffer corresponding to the address values. At the display device, an embedded stream processor is utilized to strip the header information from each packet and determine the appropriate memory location that the data is to be stored. A trigger packet is sent at the end of the data stream for a screen of on-screen-display graphics. The trigger packet includes a presentation time value corresponding to a display time for the screen of on-screen-display graphics. When the trigger packet is received, the display device transfers the data stored in the buffer to a VRAM circuit for display at the specified presentation time. The on-screen-display graphics data can be overlaid on video data for display and also displayed separately. Differential encoding is used when transferring frames of data wherein only a portion of data changes from the previous frame.
Patent DE-69914084-T2 (DE)
Inventor: BURZYNSKI STANISLAW R
IPC: A61K31/192
Filed: 1999-07-02
Granted: 2004-10-28
Abstract: Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. In a further embodiment, herein is also disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetate and (phenylacetylglutamine or phenylacetylisoglutamine) in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. Herein are also disclosed the pharmaceutical compositions used in the above methods.