baber/WOPTO huggingface dataset:
Patent DE-60044490-D1 (DE)
Inventor: BURD MEHTA TAMMY
IPC: C40B60/14
Filed: 2000-02-22
Granted: 2010-07-15
Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. 
The application particularly focusses on methods of performing a plurality of chemical reactions, for instance nucleic acid synthesis and sequencing reactions, in said microfluidic devices.
Patent DE-60102559-D1 (DE)
Inventor: ELNAGAR Y
IPC: B01J2/22
Filed: 2001-01-17
Granted: 2004-05-06
Abstract: Among the enhanced properties of the 1,3-dibromo-5,5-dimethylhydantoins described are their larger average particle sizes, their compactibility even though devoid of a binder, their excellent free-flowing and low-dust properties, and their more appealing aesthetic qualities, as compared to previously known 1,3-dibromo-5,5-dimethylhydantoins. These novel 1,3-dibromo-5,5-dimethylhydantoins can be produced, for example, by concurrently feeding (i) an aqueous solution or slurry formed from an inorganic base and 5,5-dimethylhydantoin, and (ii) a brominating agent, in proportions such that each nitrogen atom is substituted by a bromine atom, thereby forming product which precipitates in an aqueous reaction mixture. The pH of the reaction mixture is maintained in the range of about 5.5 to about 8.5.
Patent DE-60105848-D1 (DE)
Inventor: ICHINOSE HIDEHITO
IPC: A61L9/014
Filed: 2001-07-19
Granted: 2004-10-28
Abstract: The present invention provides a deodorizing article which can suppress the odor level to a predetermined level or lower and which can be used semi-permanently. The deodorizing article is produced by dispersing in gypsum series a clay mineral having a tunnel-like micro-structure, adding an optional mineral having a pore size greater than the gypsum series to the resultant mixture, and shaping the mixture. <IMAGE>
Patent DE-60111863-D1 (DE)
Inventor: DIJKEN K
IPC: B23K26/60
Filed: 2001-12-07
Granted: 2005-08-11
Abstract: Method of laser welding which comprises at least two steps: a first step wherein the laser (10) is operated for some time T1 at low intensity in order to create a melt (31) in one part (12) with little or no evaporation of matter, thereby reducing product contamination, and a further step wherein the laser is operated for a shorter time T2 at high intensity in order to push said melt (31) towards a further part (13), whereby large gaps between said parts can be bridged, yet further reducing product contamination thanks to the low laser energy needed to proceed with the further step. Optionally, a third step is performed during a third period of time (T3) in which the weld is post-heated.
Patent DE-60113648-D1 (DE)
Inventor: HJALTASON BALDUR
IPC: A23K1/18
Filed: 2001-01-15
Granted: 2005-11-03
Abstract: A method of rearing aquatic species is provided, comprising feeding the aquatic species during at least part of the larval and/or post-larval state with prey organisms, such as Artemia or rotifers, having in their total lipid content a DHA content of at least 12 wt %. The method is suitable for the rearing of fish species such as halibut, turbot, bass, bream and flounder. The total lipid content of the prey organisms further including highly unsaturated fatty acids comprising 18:3, 18:4, 20:4, 20:5 (EPA) and 22:5 fatty acids. Also the prey organisms include 5 to 35 wt % phospholipids of the total lipid content, wherein the total lipid content is at least 20 wt % on a dry weight basis.
Patent DE-60114442-D1 (DE)
Inventor: PFAENDNER RUDOLF
IPC: C08F2/38
Filed: 2001-11-06
Granted: 2005-12-01
Abstract: The present invention pertains to a process for controlled free radical polymerization or copolymerization of vinyl chloride at a temperature between 40° C. and 95° C., at a pressure between 5 and 30 bar in the presence of a stable free nitroxyl radical.
Patent DE-60117569-D1 (DE)
Inventor: CHERON VIRGINIE
IPC: C08F4/622
Filed: 2001-08-02
Granted: 2006-04-27
Abstract: The invention concerns ligands with at least a fluorosilicone substituent of general formulae (I) and (II); a method for preparing them and their use for producing catalysts useful for olefin polymerisation
Patent DE-60120104-D1 (DE)
Inventor: SELVE NORMA DR
IPC: A61P29/00
Filed: 2001-03-20
Granted: 2006-07-06
Abstract: The present invention concerns the use of compounds of the Formula (I): <CHEM> for treating different types and symptoms of acute and chronic pain, especially non neuropathic inflammatory pain in mammals. The pain to be treated may be e.g. chronic inflammatory pain, rheumatoid arthritis pain and/or secondary inflammatory osteoarthritic pain. The compounds show an antinociceptive profile and differ from classical analgesics like opioids and non-steroidal anti-inflammatory drugs (NSAIDS) and are useful as specific analgesics.
Patent DE-60121312-D1 (DE)
Inventor: MACCARRONE MAURO
IPC: C12Q1/6883
Filed: 2001-04-17
Granted: 2006-08-17
Abstract: The present invention relates to a method for the diagnosis of miscarriage in female human beings based on the detection of the presence of the enzyme anandamide hydrolase (FAAH) active in blood cells and in particular in lymphocytes, and a diagnosis kit useful in the performance of said method. <IMAGE>
Patent DE-60122348-D1 (DE)
Inventor: ALLEN JOHN
IPC: F04D29/04
Filed: 2001-09-10
Granted: 2006-09-28
Abstract: A turbocharger having an electric motor for assisting spin up of the rotor employs a shaft carrying the turbine and compressor impeller with a unitary pinned semi-floating bearing supporting the shaft and a spacer collar carrying the electric motor magnet. The unitary bearing has integral thrust faces engaging a hub of the turbine wheel and the spacer collar. A reduced diameter of the shaft received in the spacer collar allows the collar to engage a greater diameter bearing land allowing the attachment of the compressor impeller with a nut on the shaft extending through a bore in the impeller to firmly engage the impeller, spacer collar and bearing land of the shaft to fix the rotor length. The pinned semi-floating bearing with integral thrust faces provides enhanced reaction moments for negative spring forces created by the electric motor in operation and the additional length of the rotor created by the motor.
Patent DE-60127876-D1 (DE)
Inventor: JENKINS THOMAS R
IPC: A61B5/296
Filed: 2001-10-23
Granted: 2007-05-24
Abstract: A probe that includes an elongate body (12) and a steerable loop structure (30, 74) that supports electrodes (20) or other operative elements against the body tissue. <IMAGE>
Patent DE-60128505-D1 (DE)
Inventor: HOUSER KEVIN L
IPC: A61B17/32
Filed: 2001-03-30
Granted: 2007-07-05
Abstract: The present invention is directed to an ultrasonic surgical blade including a top surface, a bottom surface and a cutting-edge.The cutting-edge is defined by a cutting-surface intermediate the top surface and the bottom surface, and the top surface has a width greater than the width of the bottom surface. ., The blade may be straight or curved In one embodiment of the invention, at least a portion of the cutting-surface is substantially parallel to at least a portion of the top surface. In still another embodiment of the invention first and second side-walls intersect the top surface to form first and second cutting-edges that may be sharp or blunt. Alternately, a second cutting-edge may be defined by a second cutting surface intermediate the top and bottom surfaces. Depending on the angle between the intermediate cutting-surface and the top surface, the cutting-edge may be sharp or blunt. In yet another embodiment of the present invention, a central ridge is provided on the bottom surface of the blade to eliminate blade burrowing and improve precision during coagulation. The cutting-edge is optimized to increase cutting speed of the blade while providing desirable hemostasis. The invention is of particular benefit for breast surgery, due to its cutting and coagulation characteristics. <IMAGE>
Patent DE-60138709-D1 (DE)
Inventor: DE BELIN JACKIE Y
IPC: C07D405/06
Filed: 2001-06-05
Granted: 2009-06-25
Abstract: This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1$g(a) and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer.
Patent DE-60142965-D1 (DE)
Inventor: YAO HONG
IPC: C09J175/04
Filed: 2001-06-01
Granted: 2010-10-14
Abstract: A method is provided for adhering a polyurethane-based sealant or adhesive to a substrate. The method comprises: i) applying an aqueous primer solution onto a substrate, the primer solution comprising water, an aminotitanate compound, and preferably an epoxysilane compound having at least one epoxy group and at least two alkoxy groups; ii) applying a polyurethane adhesive or sealant to the primer-treated substrate; and iii) forming a reaction product of the primer and the polyurethane. Also provided are a substrate having a layer of a polyurethane adhesive or sealant, and a stabilized aqueous primer solution containing an epoxysilane compound and an aminotitanate compound.
Patent DE-60144511-D1 (DE)
Inventor: BULLOCK JAMES BLAKE
IPC: G08G1/0969
Filed: 2001-12-27
Granted: 2011-06-09
Abstract: A method of navigation guidance includes providing a communications node (104, 106), and a remote communications node (108). The remote communications node (108) requests a navigation route (201, 301) from communications node (102, 104, 106). The navigation route (201, 301) is from a location (202) to a destination location (204). The navigation route (201, 301) is transmitted to remote communications node (108), where the navigation route (201, 301) includes a plurality of route segments (207, 210, 211,212, 213, 254) based on location (202). The plurality of route segments include a set of multiple route threads from location (202) to destination location (204).
Patent DE-60202037-D1 (DE)
Inventor: COUGHLIN MICHAEL JOHN
IPC: A61B17/58
Filed: 2002-09-24
Granted: 2004-12-30
Abstract: The fixing plate (1) includes the proximal and distal sections (2,3) defining respective axes of symmetry (S1,S2). The projections of the axis of symmetry of the distal section to the horizontal and vertical planes inclines at the corresponding angles relative to the projection of the axis of symmetry of the proximal portion, such that the projections of the axis of symmetry intersect at a point (A1).
Patent DE-60204336-D1 (DE)
Inventor: HAMPTON R
IPC: A61B5/083
Filed: 2002-10-15
Granted: 2005-06-30
Abstract: The invention presents techniques for identifying and guiding treatment for medical conditions, based upon the carbon dioxide concentration in the patient's breath. In an exemplary application, the techniques of the invention may be used to distinguish obstructive lung disease from restrictive lung disease, even though the symptoms of the conditions are similar. The techniques of the invention may further be used to monitor the effectiveness of the treatment.
Patent DE-60205341-D1 (DE)
Inventor: MAVIN GERRY
IPC: B65D41/04
Filed: 2002-02-11
Granted: 2005-09-08
Abstract: There is described a container in combination with a closure. The container has a profile defining an opening and the closure has a profile and overlies the opening so as to provide resealable access to the contents of the container via said opening. At least part of the closure is permanently adhered to the container by means of a sealing medium interposed between the container and the closure part. The profile of the container and the profile of the closure cooperate to define a space for the containment of the sealing medium which does not communicate with the opening.
Patent DE-60206009-D1 (DE)
Inventor: ELGAARD TROELS
IPC: A23K20/28
Filed: 2002-12-20
Granted: 2005-10-13
Abstract: A natural feed additive based on plants and including tannins from Aesculus, Castanea, Quercus, Juglans, Ceratonia, Quillaja, Vitis and/or Camellia as well as a flavonoide-containing active substance from citrus fruits or grapes. The feed additive turned out to be an efficient addition to animal feed in connection with breeding of farm animals, and it is a suitable substitute for conventional growth-promoters, which are not subject to a phasing out.
Patent DE-60207176-D1 (DE)
Inventor: SHEPHERD MARTIN J
IPC: A47J27/21
Filed: 2002-11-08
Granted: 2005-12-15
Abstract: A steam-responsive switch for use in an electrical water boiling appliance comprises a main body (12) from which extends a tubular portion (13) having at or near its leading end a heat responsive bimetal (16) extending across the mouth thereof which changes shape above a predetermined temperature defining a chamber behind the member and at the opposite face of the main body (12) an electrical contact pair, the bimetal (16) engaging on its rear face a slidable pushrod (20) which extends through the main body (12) in a sealed manner to act on the electrical contact pair, the tubular portion having a steam/air vent (64) at one side thereof adjacent the rear face of the bimetal (16). <IMAGE>
Patent DE-60212881-D1 (DE)
Inventor: D EREDITA RICCARDO
IPC: A61L27/58
Filed: 2002-12-16
Granted: 2006-08-10
Abstract: A biodegradable auricular prosthetic device is described, particularly but not exclusively devised for the treatment of otitis media, comprising a tubular body having axially opposed ends and flanged at least at one of the opposed ends and at least a portion of which is produced from a material subject to biological degradation in the presence of organic liquids, wherein at least the portion made of material subject to biological degradation is produced from a polymeric material selected from the group of polyphosphazenes.
Patent DE-60215827-D1 (DE)
Inventor: YAKABE M
IPC: H04R3/06
Filed: 2002-09-06
Granted: 2006-12-14
Abstract: An electrostatic capacitance detection circuit 10 comprises an AC voltage generator 11, an operational amplifier 14 of which non-inverting input terminal is connected to specific potential (a ground in this example), an impedance converter 16, a resistance (R1) 12 connected between the AC voltage generator 11 and an inverting input terminal of the operational amplifier 14, a resistance (R2) 13 connected between the inverting input terminal of the operational amplifier 14 and an output terminal of the impedance converter 16, and an impedance element (a capacitor) 15 connected between an output terminal of the operational amplifier 14 and an input terminal of the impedance converter 16. A capacitor to be detected 17 is connected between the input terminal of the impedance converter 16 and the specific potential. <IMAGE>
Patent DE-60219480-D1 (DE)
Inventor: SMAHL JARMO
IPC: F16L23/04
Filed: 2002-07-05
Granted: 2007-05-24
Abstract: The invention relates to a branch piece for a pipework, comprising a body ( 1 ) including at least one branch fitting ( 2 ). A connecting piece ( 3 ) is arrangeable in the branch fitting ( 2 ). The branch piece includes a locking means made up of one or more parts for locking the connecting piece ( 3 ) in place.
Patent DE-60221806-D1 (DE)
Inventor: DAMBMANN CLAUS
IPC: A23C19/04
Filed: 2002-03-21
Granted: 2007-09-27
Abstract: The present invention describes a process for making cheese, comprising: a) adding to milk a carbohydrase selected from the group consisting of alpha-galactosidase, N-acetyl-galactosaminidase and neuraminidase, b) incubating so as to partially deglycosylate kappa-casein in the milk, and c) during or after step b) conditions causing clotting of the milk.
Patent DE-60223936-D1 (DE)
Inventor: OWA TAKASHI
IPC: A61K31/427
Filed: 2002-09-05
Granted: 2008-01-17
Abstract: An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): <CHEM> wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or -CH=CH-, X represents -N(R<1>)- or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents -N(R<2>)- or a nitrogen atom, and R<1> and R<2> may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.
Patent DE-60225011-D1 (DE)
Inventor: RIEPING MECHTHILD
IPC: C12N15/74
Filed: 2002-07-03
Granted: 2008-03-27
Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: 
a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which at least one or more of the genes chosen from the group consisting of rseA and rseC, or nucleotide sequences which code for these, is or are enhanced, in particular over-expressed, 
b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and 
c) isolation of the desired L-amino acid.
Patent DE-60227367-D1 (DE)
Inventor: CARR FRANCIS J
IPC: G16B15/20
Filed: 2002-02-05
Granted: 2008-08-14
Abstract: A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more potential T-cell epitopes within the amino acid sequence of human G-CSF (SEQ ID NO: 1 ); (ii) designing at least one sequence variant of at least one potential T-cell epitope identified in step (i), wherein the sequence variant eliminates or substantially reduces the MHC class II binding activity of the potential T-cell epitope; (iii) preparing, by recombinant DNA techniques, at least one modified G-CSF protein including a sequence variant designed in step (ii); (iv) evaluating at least one modified G-CSF protein prepared in step (iii) for G-CSF activity and immunogenicity; and (v) selecting a modified G-CSF protein evaluated in step (iv) that has substantially the same therapeutic G-CSF biological activity as, but substantially less immunogenicity than, human G-CSF.
Patent DE-60228648-D1 (DE)
Inventor: VERNIA MARCO
IPC: F16K31/122
Filed: 2002-05-15
Granted: 2011-03-03
Abstract: A pneumatically-actuated membrane valve (1) for fluid branching ducts (2) comprises an internally hollow cylinder (11) associable with an end (2b) of the duct (2) that is substantially coaxial thereto and inside which a plunger (12) is slidingly accommodated, the head of the plunger (12) being adapted to interact with a circular membrane (13) for closing the end (2b) of the duct (2). The plunger (12) is actuated pneumatically between a closed or open configuration, and an open or closed configuration of the end (2b) of the branching duct (2), at least one abutment (19) for stopping the stroke of said plunger (12) being formed inside the cylinder (11). <IMAGE>
Patent DE-60232318-D1 (DE)
Inventor: WEISGRABER KARL W
IPC: C12N15/74
Filed: 2002-03-14
Granted: 2009-06-25
Abstract: The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
Patent DE-60234108-D1 (DE)
Title: Gen
Inventor: MOLENAAR THOMAS JACOBUS
IPC: C07K14/705
Filed: 2002-08-28
Granted: 2009-12-03
Abstract: The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XAxA3A1A2A1Y, or a functional equivalent of said peptide. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to nucleic acids encoding for proteinaceous materials comprising the amino acid sequences of said compounds, to gene delivery vehicles comprising such nucleic acids, to binding molecules binding to said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.
Patent DE-60234336-D1 (DE)
Inventor: REIS KUNO
IPC: G06K19/077
Filed: 2002-04-11
Granted: 2009-12-24
Abstract: A data carrier (1) comprises an integrated circuit (3), which integrated circuit (3) comprises a tolerance-defined main capacitor (35) which is connected to a coil (4) of the data carrier (1), and which integrated circuit (3) comprises at least one integrated additional capacitor (32) which is optionally connectable to the coil (4) of the data carrier (1) so that a parallel switching configuration of the main capacitor (35) with the at least one additional capacitor (32) is achievable. The optional parallel arrangement of the at least one additional capacitor (32) leads to a reduction of the tolerance range of the nominal capacitance of the main capacitor (35) when the effectively realized capacitance of the main capacitor (35) is reduced by a factor F and the at least one additional capacitor (32) has a fraction K of the nominal capacitance of the main capacitor (35).
Patent DE-60237419-D1 (DE)
Inventor: LAMONT JOHN VICTOR
IPC: G01N33/94
Filed: 2002-12-20
Granted: 2010-10-07
Abstract: Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III <CHEM> wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.
Patent DE-60239524-D1 (DE)
Inventor: DEBUISSCHERT QUENTIN
IPC: C10G67/06
Filed: 2002-01-29
Granted: 2011-05-05
Abstract: The invention relates to a method for producing low-sulphur petrol comprising at least one sulphur compound transformation step consisting of the alkylation or adsorption of the sulphur compounds and/or in increasing the weight of the light sulphur compounds; at least one step involving treatment in the presence of an acid catalyst; and at least one step consisting in desulphurising at least one part of the petrol.  According to the invention, the method can also optionally comprise at least one step involving the selective hydrogenation of diolefins and, optionally, at least one fractionation of the petrol obtained into at least two fractions: light petrol and heavy petrol.
Patent DE-60302063-D1 (DE)
Inventor: CULL A
IPC: G09B9/30
Filed: 2003-05-14
Granted: 2005-12-01
Abstract: Control panels of a simulated complex system are displayed as a texture mask over a three-dimensional visual representation of an environment in which the complex system is operating. The three-dimensional visual representation is displayed in an inactive window to a user practicing or training on the simulated system. An active window underlying the visual display is used to track user inputs to the control panels. Smart graphics translate the user inputs into data elements that are sent to a full-scope simulation, and simulation conditions are returned and used to update the display of the control panels and the visual representation of the environment.