baber/WOPTO huggingface dataset:
Patent FI-20115870-A0 (FI)
Inventor: ARUMAEE URMAS
IPC: C07K/
Filed: 2011-09-05
Abstract: The present invention relates to the fields of bioactive peptides and cell-penetrating peptides as well as to the field of neurotrophic factors, i.e. growth factors for neural cells. The present invention provides peptides with length of 4 to 40 amino acids comprising the sequence CKGC (SEQ ID NO:1 ) or CRAC (SEQ ID NO:2). Pharmaceutical compositions comprising said peptides are also provided as well as the peptides for use in the treatment of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, peripheral neuropathy, epilepsy, diabetes or drug addiction. The invention is also directed to a method for promoting survival of dopaminergic neurons. In addition, peptides with length of 4 to 40 amino acids comprising the sequence CXXC (SEQ ID NO: 5) for use in the above mentioned diseases are also provided.
Patent IL-100338-A0 (IL)
Title: Methylenebisphosphonic acid derivatives
IPC: A61P19/08
Filed: 1991-12-11
Abstract: Bisphosphonic acid derivs. of formula (I) and their geometrical, optically active isomers and salts are new. In (I), R1, R2, R3 and R4 = opt. branched, opt. unsatd. 1-10C alkyl, opt. unsatd. 3-10C cycloalkyl, aryl, aralkyl, silyl, SiR3 or H, where at least one or R1, R2, R3 and R4 is H, and at least one is not H; Q1 = H, OH, halo, NH2 or OR1; R1 = 1-4C lower alkyl or acyl; Q2 = opt. branched, opt. unsatd. 1-10C alkyl, hydroxyalkyl, aminoalkyl where the O is opt. substd. by one gp.; and N is opt. substd. by 2 gps. from 1-4C lower alkyl or acyl or two gp. on N form opt. saturated or aromatic heterocylic ring or Q2 is opt. substd., opt. partially unsatd. 3-10C cycloalkyl, opt. bonded to opt. branched 1-4C alkylene gp. Specifically claimed are 21 cpds. including (1-hydroxyethylidene) bisphosphonic acid monomethyl (Ia) and monoethyl ester.
Patent IL-108501-A0 (IL)
Title: Novel antibodies and pharmaceutical compositions containing them
IPC: C12N15/00
Filed: 1994-01-31
Abstract: A monoclonal antibody having immuno-stimulatory effects, binds specifically to B lymphoblastoid cells and induces proliferation and activation of peripheral blood lymphocytes, and when injected into tumor-bearing animals elicts an anti-tumor effect.
Patent IL-110754-A0 (IL)
Title: Cell compositions preparation and therapeutic uses
IPC: A61P35/00
Filed: 1994-08-23
Abstract: Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed.
Patent IL-123326-A0 (IL)
Title: Selective membrane and process for its preparation
IPC: B01D67/00
Filed: 1998-02-16
Abstract: A process for preparing a selective composite membrane, having many practical applications, comprises synthetically impregnating at least some pores, of the upper layer containing the relatively smaller pores, in an asymmetric base membrane, with a filling material comprising an ordered macromolecular structure, by applying under superatmospheric pressure to the asymmetric base membrane, a solution of reactants adapted to interact with the formation of covalent bonds in the ordered macromolecular structure, wherein the dilution of said reactants is sufficiently low, and the pressure is sufficiently high and of such duration, so that formation of covalent bonds is initiated in pores of the upper layer as microreaction vessels and progresses within the pores of the upper layer, the reaction forming such covalent bonds being quenched at any desired stage.
Patent IL-127583-A0 (IL)
Title: Method for the production of polypeptides
IPC: C12N15/81
Filed: 1997-07-04
Abstract: The present invention relates to a novel method for the production of short chain polypeptides, including polypeptides having up to 3 disulfide bonds and/or structures rich in basic amino acid residues, and open structured short chain polypeptides, e.g. glucagon, glucagon like peptides and their functional analogues, in genetically modified yeast cells having reduced activity of YAP3 protease. The invention further comprises genetically modified yeast cells, and a method for the preparation of said yeast cells.
Patent IL-129558-A0 (IL)
Title: Epothilones C D E and F process for their preparation and compositions containing the same
IPC: A61P35/00
Filed: 1997-11-18
Abstract: Epothilone derivatives are obtained by: (1) cultivation of Sorangium cellulosum DSM 6773 in the presence of an absorption resin; (2) separation of the resin and culture followed by washing with aqueous methanol; (3) eluting the washed resin with methanol and reducing the extract; (4) partitioning the extract between methanol and hexane; (5) reducing the methanolic phase and fractionating it on a Sephadex column, and (6) isolation of the epothilones by chromatography using a methanol/water mixture. Epothilone A is followed by epothilone B, and two further fractions.
Patent IL-132324-A0 (IL)
Title: Method for treating dicotyledon seeds to recuperate therefrom an endosperm fraction and resulting fraction
IPC: B02B3/00
Filed: 1998-04-20
Abstract: The invention concerns a method for treating dicotyledon seeds containing guar gum, which consists in an abrading step wherein the cotyledons are superficially abraded to eliminate therefrom an amount of matter not less than 2 %, advantageously 4 %, preferably 5 %, and not more than about 40 %, advantageously about 30 %, preferably about 20 % of the total volume of dicotyledons. The invention is applicable to hydrocolloids.
Patent IL-143055-A0 (IL)
Title: Compositions and methods for the treatment of tumor
IPC: C07K14/52
Filed: 2000-01-19
Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
Patent IL-143770-A0 (IL)
Title: Penetration-resistant material comprising fabric with high linear density ratio of two sets of threads
IPC: D06M17/00
Filed: 2000-01-12
Abstract: The invention pertains to a penetration-resistant material having at least a double layer of fabric composed of two layers of woven fabric which are cross-plied at an angle, characterized in that the fabric is composed of a first set of threads having 3.5 to 20 threads/cm and having a linear density of at least 420 dtex, and a second set of threads having 0.5 to 8 threads/cm and having a linear density of at least 50 dtex, with the second set of threads being transverse to the first set of threads, and wherein the ratio of the linear density of the first set of threads to the linear density of the second set of threads is >4.2, more preferably >7.5. In a preferred embodiment, the first set of threads is warp threads made of p-aramid yarn and the second set of threads is weft threads of polyester yarn, and the ratio of the number of threads/cm of the first set to that of the second set is >1.
Patent IL-146689-A0 (IL)
Title: Methods and apparatus for improved sub-band adaptive filtering in echo cancellation systems
IPC: H04M1/60
Filed: 2000-05-29
Abstract: In methods and apparatus for echo cancellation using sub-band adaptive filtering, the bandwidth of each of a number of sub-band analysis filters, as well as the bandwidth of each of a number of synthesis filters, is increased as compared to a corresponding bandwidth in a conventional system. More specifically, the -3 dB bandwidths of adjacent filters in an analysis or synthesis filter bank according to the invention are designed to overlap one another. For example, each of M (an integer) sub-band filters in an analysis or synthesis filter bank according to the invention can include a -3 dB bandwidth somewhat greater than 1/M times a total bandwidth of interest. The increase in bandwidth tends to cancel aliasing effects resulting from sub-band down-sampling, and an echo canceling device according to the invention can therefore provide superior output signal reconstruction as compared to conventional devices.
Patent IL-178373-A0 (IL)
Title: Process for the preparation of alkoxycarbonylmethoxy cyclopentanes
IPC: C07D317/72
Filed: 2006-09-28
Abstract: The present invention provides a process for the preparation of a compound of formula (I): wherein R<SUP>1 </SUP>is C<SUB>1-6 </SUB>alkyl; R<SUP>2 </SUP>and R<SUP>3 </SUP>are, independently, C<SUB>1-6 </SUB>alkyl; and R<SUP>4 </SUP>is C<SUB>1-6 </SUB>alkyl or benzyl (wherein the phenyl ring of benzyl is optionally substituted by nitro, S(O)<SUB>2</SUB>(C<SUB>1-4 </SUB>alkyl), cyano, C<SUB>1-4 </SUB>alkyl, C<SUB>1-4 </SUB>alkoxy, C(O)(C<SUB>1-4 </SUB>alkyl), N(C<SUB>1-6 </SUB>alkyl)<SUB>2</SUB>, CF<SUB>3 </SUB>or OCF<SUB>3</SUB>); the process comprising reacting a compound of formula (II): wherein R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as defined above, with a suitable base; and reacting the product so formed with R<SUP>1</SUP>OC(O)CH<SUB>2</SUB>X, wherein R<SUP>1 </SUP>is as defined above and X is chloro, bromo or iodo; wherein the process is carried out in a suitable solvent at a temperature in the range -40° C. to -5° C.; and wherein at least 0.2 moles of the compound of formula (II) are used in the process.
Patent IL-185904-A0 (IL)
Title: Mechanical locking system for floor panels and a method to disconnect floor panels
Filed: 2007-09-11
Abstract: Building panels (1, 1') are shown, which are provided with a mechanical snap locking system with flexible tongue (30) made of a separate material in order to reduce snapping resistance and/or increase locking strength.
Patent RO-126641-A0 (RO)
Title: Process for preparing anti-fetal goat- and sheep-serum
Inventor: ZAMFIRESCU STELA FILOFTEIA
IPC: A61K39/00
Filed: 2010-12-10
Abstract: The invention relates to a process for preparing an anti-fetal goat- and sheep-serum meant to be employed in veterinary medicine and stock raising for early prediction of pregnancy in ruminants. According to the invention, the process consists in collecting in sterile drops of PBS medium with 4% BSA the preimplanted embryos of 14 and 15 day and passing them by 8...10 successive baths of sterile medium, followed by separately homogenizing the goat and sheep embryos to obtain a homogenized fetal antigen which is mixed in a ratio of 1/1 with a Freund adjuvant, distributing it separately and then injecting it to rabbits for an immunization period of 15 days, after which the rabbit anti-fetal sheep- and/or goat-serum is collected, centrifuged to obtain the anti-pregnancy-protein serum which is subjected to a hemagglutination assay, where the presence of such a reaction indicates the pregnancy.
Patent RO-127239-A0 (RO)
Title: Safety ball seal
Inventor: PREDA CONSTANTIN
IPC: G09F3/03
Filed: 2011-02-10
Abstract: The invention relates to a safety ball seal meant to ensure the integrity of an enclosure content. According to the invention, the seal consists of a parallelepipedal body () wherein there is fixed one of the ends of the sealing cable (), by means of a lug boss (), the body () having a cylindrical hole on the upper wall and one on the lower wall, said holes being coaxial, through which the free end of the sealing cable () passes, the body () having on the inside a longitudinal taper groove () wherein there slides a latch () having on its upper edge a semicylindrical recess () meant to accommodate a ball () which blocks the free end of the sealing cable () with a central cylindrical orifice () cut in the upper wall of the body (), having the axis perpendicular on the advance direction of the latch ().
Patent RO-129101-A0 (RO)
Title: Rotary equipment for filter launching
Inventor: MIHALACHIOIU NICOLAE EDDMON
IPC: E21B43/10
Filed: 2013-07-11
Abstract: The invention relates to a rotary equipment for launching a sand filter and for sealing a production casing column used within a slanting well, horizontal wells included, through which an oil deposit is exploited. According to the invention, the equipment consists of a rotary packer (A) and a recovering launcher (B), their advance into a production casing column taking place due to the rotation moment transmitted by some wedges (30) of the recovering launcher (B) which enter some grooves (a) cut into the packer (A), the release of the launcher (B) being achieved by launching from the ground surface a ball (29) which, due to its sealing against a truncated cone-shaped surface (h') of a seat (26), creates a pressure inside a launching string, leading to the shearing of some pins (24) which allows the recovering launcher (B) to be released from the rotary packer (A), the ring-shaped space being sealed by pressing some corrugated surfaces (h') of some expanding cutters (14) onto a resting surface (s) of an upper body (8) which achieves the compression of a sealing gasket (5) which is still maintained in the compressed state after the removal of the pressing force by a blocking system consisting of a cut resilient ring (7) and a blocking bush (6).
Patent AP-2000001728-A0 (AP)
Title: Novel composition.
Inventor: CUMMINGS PAUL JOHN
IPC: A61P25/06
Filed: 1998-07-07
Abstract: Pharmaceutical composition comprising an SSRI in quick-release form and a ?-blocker in sustained-release form
Patent LU-87304-A1 (LU)
Inventor: JEAN MAIGNAN
IPC: C07H13/12
Filed: 1988-07-29
Abstract: Compound corresponding to the formula: <IMAGE> in which: R3 and R4 which are identical or different, denote hydrogen, alkyl, alkenyl, cycloalkyl, aryl or aralkyl or a heterocyclic ring; R1 and/or R2, independently of each other, denote hydrogen, a carbamoyl group, of formula: <IMAGE> provided, however, that R1 and R2 do not simultaneously denote a hydrogen atom; R7 and/or R8, independently of each other, denote hydrogen, alkyl, cycloalkyl, aryl or aralkyl which are substituted by a hydroxyl, amino and/or carboxylic group, a sugar residue or a heterocyclic ring.
Patent MA-19837-A1 (MA)
Inventor: JACQUES MARONGIU
IPC: C08L13/02
Filed: 1983-07-05
Abstract: Aqueous dispersions containing a mixture of 20 to 80% by weight of a latex of a copolymer A of butadiene, styrene and at least one unsaturated carboxylic acid, and 80 to 20% by weight of latex of a copolymer B of styrene, an alkyl acrylate and, if appropriate, at least one unsaturated carboxylic acid. The dispersions can be used as binders for the preparation of adhesive compositions suitable for joining or gluing two or more elements, and particularly suitable when at least one of the elements consists of a material which is difficult to glue, such as polyvinyl chloride.
Patent MA-37960-A1 (MA)
Inventor: VOERSTE ARND
IPC: C07D231/56
Filed: 2013-09-30
Abstract: (heterocyclic compounds) يتعلق التطبيق الحالي باستخدام مركبات دائرية مغايرة بما في دلك المفصليات (animal pests) من أجل مقاومة الآفات الحيوانية ، بمركبات (nematodes) و الديدان الخيطية (insects) ، الحشرات (arthropods) دائرية مغايرة جديدة، بعمليات لتحضيرها و بمركبات وسطية لتحضير المركبات الدائرية المغايرة
Patent MA-38344-A1 (MA)
Title: Composition dermatologique antimicrobienne topique
Inventor: LEFEVRE JEAN-MARIE
IPC: A61P31/00
Filed: 2014-02-24
Abstract: L'invention concerne une composition utilisable en dermatologie. La composition dermatologique antimicrobienne topique pour utilisation en médecine humaine et vétérinaire, comprend en association au moins un peptide antimicrobien cationique et de l'acide hyaluronique de poids moléculaire moyen ou un de ses sels application au traitement des infections microbiennes cutanées, phanériennes ou muqueuses.
Patent MA-44921-A1 (MA)
Title: Procédé d'étude ontologique non supervisée automatisée d'aspects structuraux dans des micrographes électroniques
Inventor: RYNER MARTIN
IPC: G06K9/62
Filed: 2018-07-02
Abstract: Le procédé consiste à diviser des objets sombres (102, 122, 123, 126), des sous-structures et un arrière-plan d'une image provenant d'un microscope électronique (304) en segments (128, 142, 150) par une analyse de valeurs de pixel. Les segments sont transformés et alignés de sorte que les objets, les sous-structures et l'arrière-plan transformés soient comparables de manière significative. Les segments transformés (128', 142', 150') sont regroupés en classes qui servent à une étude ontologique d'échantill
Patent MA-54781-A1 (MA)
Title: Règles d'omission de csi permettant un bilan de csi de type ii amélioré
Inventor: FAXÉR SEBASTIAN
IPC: H04B7/06
Filed: 2020-04-27
Abstract: L'invention concerne des systèmes et des procédés d'omission d'informations d'état de canal (csi) permettant un bilan de csi de type ii amélioré. Dans un mode de réalisation, un procédé mis en œuvre par un dispositif sans fil de bilan de csi dans un système de communication cellulaire consiste à effectuer une procédure d'omission de csi permettant d'omettre une partie déterministe d'informations de commande de liaison montante (uci) pour un bilan de csi et de fournir ainsi un bilan de csi de taille réduite. La réalisation de la procédure d'omission de csi consiste à diviser une pluralité de coefficients de combinaison linéaire (lc) en au moins deux groupes d'omission de csi présentant des niveaux de priorité associés et, en fonction des niveaux de priorité desdits groupes d'omission de csi, à omettre des coefficients de lc compris dans au moins un desdits groupes d'omission de csi du bilan de csi de taille réduite. Le procédé consiste en outre à transmettre le bilan de csi de taille réduite. Ainsi, une partie déterministe des uci est omise afin de fournir le bilan de csi de taille réduite.
Patent UY-23455-A1 (UY)
Title: Contacto aprisionador tubular de filo cortante.-
Inventor: GERKE DIETER
IPC: H01R4/24
Filed: 1992-08-06
Abstract: El invento se refiere a un contacto aprisionador tubular de filo cortante, utilizado para contactar el conductor de un cable perpendicularmente al eje del cuerpo tubular, pensado especialemente para conductores de cables destinado a la técnica de telecomunicaciones, consistente en una envolvente tubular (15) provista de una ranura aprisionadora (3) para el conductor aislado (5), y de una ranura de contacto aprisionada de filo cortante (2) en el interior del cuerpo tubular (12) para la conexión sin aislamiento del conductor (5). Para mejorar el contacto aprisionador tubular de filo cortante en el sentido de que la ranura de contacto (2) quede libre de las influencias de los movimientos en la ranura aprisionadora (3) y con objeto de permitir ajustarse a tolerancias exactas, de acuerdo con el invento se prevé que una parte (13) de la envolvente tubular (15) sea doblada radialmente hacia el interior del cuerpo tubular (12), que esté provista de una ranura de contacto aprisionadora de filo cortante (2), y que la ranura aprisionadora (3) situada en frente de la ranura de contacto aprisionadora de filo cortante (2) esté recortada en la envolvente tubular (15). La figura 1 ilustra el objeto de la invención visto de arriba.
Patent UY-27906-A1 (UY)
Title: Inhibidores de quinasas
Inventor: CONNOLLY CLEO J CHIVIKAS
IPC: A61P11/00
Filed: 2003-07-24
Abstract: Esta invención proporciona pirimidopirimidinas, dihidropirimidopirimidinas, piridopirimidinas, naftiridinas y piridopirazinas fenil sustituidas de fórmula general :que inhiben las enzimas quinasa y tirosinaquinasa dependientes de la ciclina, los procedimientos y compuestos intemedios para su síntesis, así como composiciones farmacéuticas y procedimientos para su uso en tratamiento, inhibición o prevención de enfermedades asociadas con trastornos de proliferación celular, que incluyen angiogénesis, aterosclerosis, reestenosis y cáncer.
Patent UY-30761-A1 (UY)
Title: Derivados de 2.3-dihidroimidazo(1,2-c) quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogénesis
Inventor: SCOTT ROBERT WILLIAM
IPC: C07D487/04
Filed: 2007-12-04
Abstract: RESUMEN Esta invencion se refiere a nuevos compuestos de 2,3-dihidroimodazo [1,2-c]quinazolina, a composiciones farmacéuticas que contienen dichos compuestos y a la utilizacion de esos compuestos o composiciones para la inhibicion de fosfotidilinositol-3-quinasa (P13K), y para el tratamiento de enfermedades asociadas con la actividad del fosfotidilinositol-3-quinasa (P13K) en particular para el tratamiento de transtornos de angiogénesis y/o hiper-proliferativos, como un agente unico o en combinacion con otros ingredientes activos.
Patent UY-30915-A1 (UY)
Title: Método de tratamiento de canceres
Inventor: ERICKSON-MILLER CONNIE L
IPC: A61K31/41
Filed: 2008-02-13
Abstract: Se inventa un método para tratar cánceres y síndromes precancerosos en un mamífero, incluyendo un ser humano, que lo necesita, que comprende la administracion de una cantidad terapéuticamente eficaz de un agonista no peptídico del receptor de TPO a dicho mamífero.
Patent UY-31514-A1 (UY)
Title: Una ciano piperidinil-fenil-oxazolidinona y uso de la misma
Inventor: CANO MONSERRAT
IPC: A61K31/4523
Filed: 2008-12-05
Abstract: La invencion proporciona un compuesto de formula (I), o cualquiera de sus enantiomeros o mezclas de los mismos, o sus sales farmacéuticamente aceptables o solvatos, para uso como un medicamento. El compuesto de formula (I) es activo contra patogenos humanos y veterinarios Gram-positivos y algunos Gram-negativos con una actividad inhibidora débil de la monoamina oxidasa (MAO). Son utiles para el tratamiento de infecciones bacterianas. La invencion también describe formas del compuesto (S)-N.[3-[4-4-ciano-piperidin-1-il)-3-fluoro-fenil]-2-oxo-oxazolidin-5-ilmetil}-acetamida.
Patent ES-172073-A1 (ES)
Title: PROCEDIMIENTO PARA LA OBTENCIoN DE NUEVOS COMPUESTOS HETEROCiCLICOS
Filed: 1946-01-08
Abstract: Procedimiento para la obtención de nuevos compuestos heterocíclicos especialmente de nuevos derivados de quinolina y de quinazolina que llevan en la posición-2 un grupo arilamino exento de sustitutivos ácidos y en la posición-4 un grupo básico de la fórmula **(ver fórmula)** en la que R" representa hidrógeno o un alquilo o sencillamente un grupo alquilo sustituido A un grupo de enlace que es alifático o alicíclico o alifático-carbocíclico y está exento de sustitutivos ácidos y NRR' es un amino enérgicamente básico o un grupo amino sustituido o un grupo amino primario o secundario acilado y que puede opcionalmente llevar en las otras posiciones nucleares uno o más sustitutivos no ácidos caracterizándose porque consiste en hacer reaccionar una arilamina adecuada exenta de sustitutivos ácidos con una quinolina o quinazolina que lleva en la posición-4 el grupo básico **(ver fórmula)** y en la posición -2 un grupo lábil tal como un átomo de halógeno o un radical hidrocarburo que va unido por una cadena de éter o tioéter.
Patent ES-179000-A1 (ES)
Title: PROCEDIMIENTO DE ESTAMPACIoN SOBRE TEJIDOS PREVIAMENTE PREPARADOS CON MEZCLAS DE NITROCELULOSA
Filed: 1947-07-21
Abstract: Procedimiento de estampación sobre tejidos previamente preparados con mezclas de acetato de nitrocelulosa caracterizado porque la estampación se efectúa por medios como el de bach aerograf lionesa o por medio de máquinas de estampar o litografiar sobre telas que previamente se han impregnado o pintado a cuyo efecto la preparación se compone de una mezcla de acetato de celulosa nitrocelulosa o aceites vegetales que disueltos por maceración con disolventes apropiados tales como por ejemplo la acetona el alcohol metílico o butílico rebajados con benzol u otros como disolventes de dichas materias se plastifican con cualquier plastificante de los usuales como por ejemplo el aceite de ricino el ftalato de dibutilo el sulfato de triclecilo y se añaden cargas de carbonato de cal litopones oxidos de zinc o análogos con sus colorantes si se desea un acabado coloreado formando dichos componentes un barniz o pintura que se aplica por medio de máquinas de las conocidas de pintar de cuchilla o raclillo y que extendidas las capas sucesivamente pasan por unas placas calentadas o que se secan por varios procedimientos sea por estufas o simplemente extendidas las telas asi barnizadas.