baber/WOPTO huggingface dataset:
Patent JP-2001513196-A (JP)
Title: 通信システムにおいて遠隔装置が送信した信号の到達角度を判定する方法および装置
IPC: G01S3/30
Filed: 1998-01-08
Abstract: (57)【要約】
振幅差に基づく到達角度推定（ＡＤ−ＡＯＡ）を利用することによって、ワイヤレス通信システム内における遠隔装置の位置を判定する。即ち、マルチパス散乱を生じた信号（１１７）のプロンプト・レイ（４０１）を多数のアンテナ（１０３，１０５）において受信する。信号コンバイナ／平均計算部（３０７）によって、各アンテナにおいて受信したプロンプト・レイ（４０１）を結合する。次に、信号コンバイナ／平均計算部（３０７）は、多数のパワー制御群にわたって合計したプロンプト・レイのエネルギの平均を取り、合計プロンプト・レイに対して高精度のエネルギ・レベルを判定する。次に、他のセクタにおいて合計したプロンプト・レイの平均エネルギ値と共に、この合計したプロンプト・レイの平均エネルギ値をＡＯＡ計算部（３０９）に出力する。各セクタから受信した合計プロンプト・レイのエネルギ値を分析し、適切な到達角度を判定する。
Patent JP-2000508510-A (JP)
Title: 電流制御方法
IPC: G05F1/46
Filed: 1997-04-10
Abstract: (57)【要約】
誘導性負荷（４）、特に電磁式圧力調整器の電流制御のために、電流実際値の検出を電流調整器（２）の出力信号に対して時間的に遅らせて同期して行う方法を提案する。こうすることによって電流実際値に過渡状態が重なって検出されるという事態を回避することができる。
Patent JP-H11504725-A (JP)
Title: マイクロエレクトロニクスばね接触部品
IPC: H01L21/66
Filed: 1997-05-15
Abstract: (57)【要約】
ばね接触部品は、能動半導体デバイスのような電子部品とすることが可能な基板表面上に、堆積されたマスク層により画定された開口の中に少なくとも１層の金属材料を堆積させて組立てられる。それぞれのばね接触部品は、底部端及び接点端、本体部分を有する。接点端は、ｚ軸（異なる高さで）に段をなし、かつ底部端からｘ又はｙ方向の少なくとも１方向に段をなす。この方法によれば、複数のばね接触部品が、基板上の他のものと規定された空間の関係をもって組立てられる。ばね接触部品は、それらの間で電気接続をもたらすように、他の電子部品の端子と一時的の（すなわち、圧力）又は不変の（例えば、半田付け又はろう付け又は導電性粘着物により結合される）接続を形成する。実施例では、半導体デバイスをバーンイン及び／又はテストするために、一時的の接続が半導体デバイスに使用することが可能なように、ばね接触部品が半導体ウエハに存在する半導体デバイス上に配置される。
Patent JP-2002514109-A (JP)
Title: シリコーン材料を利用した改良型多層ゴルフボール
IPC: A63B37/04
Filed: 1998-03-27
Abstract: (57)【要約】
本発明は、コア(10)、内側カバー層（14）、および外側カバー層(16)を備える、改良型多層ゴルフボール(5)を目的とする。内側カバー層（14）は、高酸アイオノマーまたはアイオノマーブレンドから構成される。外側カバー層(16)は、軟質の、極めて低弾性率のアイオノマーまたはアイオノマーブレンド、もしくは、ポリウレタン、ポリエステル、またはポリエステルアミドなどの非アイオノマー熱可塑性エラストマーから構成される。ゴルフボールは、少なくとも１つの内部層、および／または、シリコーン材料を含むコアを更に備える。
Patent JP-2001524956-A (JP)
Title: 迅速溶解性の頑丈な投与形態物
IPC: A61K9/00
Filed: 1998-04-13
Abstract: (57)【要約】
本発明は、ばらで保管し、パッケージ化しかつ処理することができる硬質タブレットに関する。タブレットは粗粉を最小にした状態で患者の口内で素早く溶解する。タブレットは、非直接圧縮充填剤と比較的高含量量の滑剤とのマトリックスに混合した活性成分から形成される。
Patent JP-2001519035-A (JP)
Title: 超音波による境界面領域の検査装置
IPC: G01S7/52
Filed: 1998-03-06
Abstract: (57)【要約】
少なくとも１つの送信ユニット（５）と、受信ユニット（１７）と、加算素子を備えた評価ユニット（２７）とを有する、超音波により境界面領域を検査する装置であって、前記送信ユニットにより振幅の調整可能な送信信号が少なくとも１つの基本周波数において形成可能であり、前記受信ユニットにより、少なくとも１つの基本周波数、並びに送信信号の少なくとも１つの基本周波数に所属の高調波のうち少なくとも最低のものがその周波数振幅について受信信号として検出され、前記評価ユニットでは、受信信号の周波数振幅が測定値に結合される、形式の装置において、測定値が基本周波数の単純な周波数振幅と、基本周波数の２倍において所属の第２高調波の周波数振幅の少なくとも２倍の負の値を有する。このことにより、被検境界面領域（１４）における結合力の絶対測定が行われる。
Patent JP-2002513287-A (JP)
IPC: A61K39/02
Filed: 1997-12-11
Abstract: The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to eukaryotic cells cultured in vitro or to cells in vivo, such as by oral administration of the attenuated Salmonella comprising the eukaryotic expression vector.
Patent JP-2001507771-A (JP)
Title: 管状連結部用応力低減溝
IPC: E21B17/042
Filed: 1998-05-20
Abstract: (57)【要約】
本発明は、ねじ付きパイプ連結部に関し、かつボックス部材、ピン部材および部材のいずれかのねじに形成された連続した溝を含む管状連結部用応力低減溝である。ボックス部材は、スタブフランク、ロードフランク、谷底および山の頂を有する一般的にあり型でテーパ型の雌ねじを有する。雌ねじは、始点および終点を有し、一方向に幅が広くなっている。ピン部材もまた、スタブフランク、ロードフランク、谷底および山の頂を有する一般的にあり型でテーパ型の雄ねじを有する。雄ねじは、他方向に幅が広くなっており、これにより各ねじの相補形のフランクが、連結部の回転組立て中に嵌合し、かつ連結部の回転組立て時にはねじ間の流体の流れを抑えるシール面を形成する。雌ねじおよび雄ねじのいずれかの部分は、その谷底に形成された連続した溝を有する。溝は、一方のねじの始点および終点のいずれかからこのねじの始点と終点の間の点まで続いており、これにより回転組立て中にシール面の間に蓄積された、ねじに適用されているねじ潤滑剤の圧力を低減する。
Patent MX-145056-A (MX)
Inventor: KOOPMAN NICHOLAS G
IPC: H01L23/34
Filed: 1977-09-02
Abstract: A method for making a circuit package which exhibits an excellent heat transfer path from a semiconductor chip or other heat generating device to the heat sink can or cover of the package. A heat conducting pad is placed in proximate relationship to either the heat sink or to a surface of the chip and is metallurgically bonded to the other. In one of the preferred embodiments a low melting point solder, such as indium or an alloy thereof, is metallurgically bonded to the inside of the heat sink cover in a limited central region thereof. The solder is then positioned adjacent the chip and reflowed to substantially fill in the gap between the solder and the chip, but with no stress between the chip and the solder. The assembly exhibits excellent heat transfer from the chip to the cover and any associated heat dissipating structures. The preferred method involves the reflow of a mass of solder against the back side of the chip, which has previously been solder-bonded on the front side to conductors on the surface of an alumina substrate.
Patent MX-151346-A (MX)
Inventor: GUPTE ARUN RAJARAM
IPC: G01F11/28
Filed: 1980-11-06
Abstract: The invention is directed to an apparatus for drawing off powder in metered quantities of from about 0.5 to 10 mg, comprising a tubular member having a dosing chamber at one end, the chamber having walls consisting of porous material and the outer end of the chamber walls being air-tight, and being provided at the other end with a means for connecting the tubular member to vacuum and/or compressed air sources. The invention is also directed to a method of using such an apparatus.
Patent MX-156752-A (MX)
Inventor: HUENNINGER EDWARD A
IPC: F28F9/02
Filed: 1983-09-23
Abstract: A waterbox for a shell and tube heat exchanger is disclosed. The waterbox is attached at one end of the heat exchanger to a tube sheet through which heat exchange tubes extend. Nozzle connections are made to the waterbox through a top member having an access opening which projects onto an area of the tube sheet through which the heat exchange tubes extend. The openings of the nozzles project onto areas on the tube sheet through which no heat exchange tubes extend. A removable cover is positioned over the access opening in the top member so that, when fluid flow conduits are connected to the nozzles on the top member, the conduits and removable cover are positioned relative to each other to allow removal of the cover without disturbing the connections between the conduits and the nozzles. In an alternative embodiment, the conduit connections are made through the back wall of the tube sheet rather than through the top member. This allows use of a waterbox with a removable top member having no nozzles.
Patent NZ-208972-A (NZ)
Title: N-aminomethyl-3-phenyl-4-cyanopyrrole derivatives and microbicidal compositions
Inventor: NYFELER R
IPC: C07D207/34
Filed: 1984-07-20
Abstract: The invention relates to novel N-aminomethyl-3-phenyl-4-cyanopyrrole derivatives of the formula I    <IMAGE>  (I)  wherein R1 and R2 are each independently hydrogen, halogen, methoxy or methylthio, Z is a group    <IMAGE> (a)   <IMAGE> (b)   <IMAGE> (c)   wherein R3 and R4 are each independently hydrogen, C1-C6alkyl which is unsubstituted or substituted by cyano, C1-C6alkoxy or C1-C6alkoxycarbonyl; or are C3-C6alkenyl, C3-C6alkynyl, C3-C7cycloalkyl, benzyl or benzyl which is substituted by halogen, C1-C6alkyl, C1-C6haloalkyl and/or C1-C6alkoxy, or phenyl or phenyl which is substituted by halogen, C1-C6alkyl, C1-C6haloalkyl and/or C1-C6alkoxy, with the proviso that only one of R3 or R4 can be hydrogen, R5 and R6 are each independently hydrogen, C1-C6alkyl, C1-C6alkoxycarbonyl, or both taken together form a fused aromatic ring, n is 4 or 5, X is oxygen, sulfur, >C=O or >N-R, R7 and R8 are each independently hydrogen, C1-C6alkyl or C1-C6alkoxycarbonyl, and R9 is hydrogen, C1-C6alkyl, formyl, C1-C6alkanoyl or C1-C6alkoxycarbonyl. The invention further relates to the preparation of the compounds of formula I and to microbicidal compositions which contain at least one of said compounds. Also disclosed is a method of controlling phytopathogenic micro-organisms, which comprises the use of the novel compounds or compositions.
Patent NZ-215766-A (NZ)
Title: Production of alcohols and/or esters by catalytic hydrogenation of carboxylic acids and catalyst therefor
Inventor: KITSON M
IPC: C07C69/24
Filed: 1986-04-09
Abstract: Ethanol is produced from acetic acid or propanol is produced from propionic acid by contacting either acetic acid or propionic acid in the vapour phase with hydrogen at elevated temperature and a pressure in the range from 1 to 150 bar in the presence of a catalyst comprising as essential components (i) a noble metal of Group VIII of the Periodic Table of the Elements, and (ii) rhenium, optionally on a support, for example a high surface area graphitised carbon.
Patent NZ-233785-A (NZ)
Title: N-phenylalkyl substituted alpha-amino carboxamide derivatives and pharmaceutical compositions
Inventor: DOSTERT PHILIPPE
IPC: A61K31/34
Filed: 1990-05-23
Abstract: N-phenylalkyl substituted  alpha -amino carboxamide derivatives of formula (I) <CHEM> wherein R is C1-C8 alkyl, C3-C8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a -(CH2)m- or -(CH2)p-X-(CH2)q- group wherein X is -O-, -S- or -NR4-; R1, R2, R3, R min 3, R4, n, m, p and q are as herein defined; and each of R5 and R6 is independently hydrogen or C1-C6 alkyl, and the pharmaceutically acceptable salts thereof, are active on the central nervous system and can be used as anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and/or hypnotic agents in mammals.
Patent NZ-234151-A (NZ)
Title: Esters of a non-reducing sugar and one or more fatty acids and process for their purification and extraction
Inventor: KOERTS KEES
IPC: C07H13/06
Filed: 1990-06-20
Abstract: The invention relates to a process for purifying crude products containing esters of a non-reducing sugar like sucrose, and one or more fatty acids such as palmitic acid, stearic acid etc. by subjecting said crude esterification products to an extraction treatment with supercritical carbon dioxide. After carrying out this extraction treatment a residue comprising the fatty acid esters of non-reducing sugars, the unreacted sugar and the salts as well as an extract comprising the fatty acids, fatty acid alkyl esters and also any solvents, if present, are obtained. The unreacted sugar and salts, present in the obtained residue, can be removed from said residue by, for example, a washing operation resulting in a final product of pure esters of the non-reducing sugar and one or more fatty acids. This last removal step concerning the unreacted sugar and salts may also be carried out before the application of the above indicated extraction treatment with supercritical carbon dioxide.
Patent NZ-234487-A (NZ)
Title: Substituted 2-imino-3-alkylbenzothiazolines, preparation and pharmaceutical compositions thereof
Inventor: JIMONET PATRICK
IPC: A61K31/425
Filed: 1990-07-12
Abstract: Compounds of formula: <IMAGE> in which R1 denotes a substituted 1-piperazinyl, substituted 1,2,3,6-tetrahydro-1-pyridyl or substituted piperidino radical, R2 denotes a polyfluoroalkoxy radical and n is equal to 2 or 3, salts of these compounds with an acid, processes for their preparation and medications containing them.
Patent NZ-238783-A (NZ)
Title: Carrier; pharmaceutical powder between fibres of a velvet or velour-like material
Inventor: GUPTE ARUN R
IPC: A61J3/00
Filed: 1991-06-28
Abstract: In order to produce an aerosol, a velvety or velours-like material charged with a powder is brought into an air current.
Patent NZ-243183-A (NZ)
Title: Contact lens: corrugations on peripheral zone aid lens orientation
Inventor: NEWMAN STEVE
IPC: G02C7/04
Filed: 1992-06-17
Abstract: PCT No. PCT/AU92/00290 Sec. 371 Date Jan. 18, 1994 Sec. 102(e) Date Jan. 18, 1994 PCT Filed Jun. 16, 1992 PCT Pub. No. WO92/22845 PCT Pub. Date Dec. 23, 1992.An improved contact lens (1) having an optic zone (4) and a radial planar zone (5) such that the radial planar zone has an array of contours which are defined by a waveform or waveforms (2, 3) comprising crests and troughs on the back and/or front surface of the lens. The waveform(s) provide(s) means to enable proper location and orientation of the lens on the eye of a wearer by interaction between the lens, the eye and an eyelid and facilitating increased gas transmission through the lens.
Patent NZ-256755-A (NZ)
Title: Waste treatment; material is mixed with liquid to form a slurry which is pressurised and heated, the pressure then being reduced and temperature further raised
Inventor: BASKIS PAUL T
IPC: C10B47/26
Filed: 1993-09-15
Abstract: This disclosure relates to a processor comprising means for mixing a process material with a process liquid (such as water) and forming an emulsion or slurry. Means is provided for pressuring and heating the slurry, and the slurry is then fed to means for quickly reducing the pressure to a relatively low value and further increasing the temperature. The rapid drop in pressure and increase in temperature causes components of the slurry to convert to volatile gases and separate from the remainder of the slurry which is removed from the processor in the form of solids. The gas is fed to one or more condensers which separate the gas into useful liquids such as various grades of oil.
Patent NZ-262372-A (NZ)
Title: Oxa (or thia) diazole-subststituted 1-azabicyclo derivatives
Inventor: SAUERBERG PER
IPC: A61P25/28
Filed: 1994-03-04
Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Patent NZ-264271-A (NZ)
Title: Tyre buffing machine chevron rasp blade with working edges part of an ellipse
Inventor: JENSEN WAYNE
IPC: B29D30/54
Filed: 1994-08-19
Abstract: A tire rasp blade for use in a tire buffing machine having a rotating hub. A set of rasp blades (10) is arranged in a plurality of circumferential rows. Each of the blades has a non-planar elongated body (12) with generally planar portions (14,16), and an arcuate working edge (20) having teeth (22) which extend in a direction generally parallel to the direction of hub rotation. The working edge includes two elliptical-shaped segments (24,26). <IMAGE>
Patent NZ-278526-A (NZ)
Title: Use of polyalkylene oxide-modified siloxanes for cleaning contact lenses
Inventor: DESAI NAYAN NARAYAN
IPC: C11D1/82
Filed: 1994-12-19
Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.
Patent NZ-281431-A (NZ)
Title: Alkylamide-substituted indole derivatives
Inventor: BITONTI ALAN JOSEPH
IPC: A61K31/40
Filed: 1995-01-31
Abstract: The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.
Patent NZ-295278-A (NZ)
Title: Cleaning chemical reactor using solvent, periodically passing solvent through adsorbent
Inventor: KARLSSON PATRIK
IPC: B08B9/027
Filed: 1995-10-20
Abstract: The present invention relates to a method for cleaning a container (30) and conduits (32, 33, 36) associated with said container by adding a cleaning solvent to the container and circulating said solvent through said conduits back to said container. In accordance with the invention the cleaning solvent additionally is forced intermittently through a filter unit (1) containing an absorbent material, preferably active carbon (3), and then is allowed to flow through said conduits to said container, said container and conduits thus intermittently being flushed with clean solvent. The container may be a reaction vessel for chemical processes.
Patent NZ-295327-A (NZ)
Title: Spark gap ignition arrangement
Inventor: GUMLEY RICHARD JOHN
IPC: H02H9/06
Filed: 1995-11-17
Abstract: The application is predicated on the concept of increasing or amplifying the voltage across the spark gap in order to ignite the gap when required thus enabling ignition of the spark gap when required.  The incremental voltage to obtain gap ignition is additive to any voltage already across the gap, and is additive irrespective of polarity.  That is if a positive over-voltage pulse arrives, the main gap has an increased positive voltage  If a negative over-voltage pulse arrives, the main gap has an increased negative voltage applied.
Patent NZ-295837-A (NZ)
Title: Polyolefin compositions exhibiting heat resistivity, low hexane-extractives and controlled modulus
Inventor: DEGROOT JACQUELYN A
IPC: B29C48/10
Filed: 1995-10-04
Abstract: The subject invention provides a polymer mixture having high heat resistivity, low hexane extractive and controllably lower or higher modulus. The mixture is comprised of at least one first substantially linear ethylene polymer, Component (A), and at least one second ethylene polymer which is a homogeneously branched polymer, heterogeneously branched linear polymer or a non-short chain branched linear polymer. When fabricated into film, the mixture is characterized by a heat seal initiation temperature which is substantially lower than its Vicat softening point as well as a high ultimate hot tack strength. When fabricated as a molded article, the mixture is characterized by high microwave warp distortion while maintaining a lower modulus. The polymer mixture is particularly well-suited for use in multilayer film structures as a sealant layer for such applications as cook-in packages, hot-fill packages, and barrier shrink films. In molding applications, the mixture is well-suited as freezer-to-microwave food storage containers and lids which maintain good flexibility at low temperature to allow easy openability of such containers.
Patent NZ-306734-A (NZ)
Inventor: CHAN MING FAI
IPC: A61P15/00
Filed: 1996-04-04
Abstract: light polarising panel comprises a plurality of layers of translucent material.  At least one gap is provided between a pair of adjacent layers and at least one of the layers is a polarising layer formed of cellular material with layered elliptical cells.  The polarising layer is formed firstly by a hot roll calendering process such that the cells become substantially elliptical.  The material is then placed under tension and heated and passed to a pair of heated laminating rolls. The effect is to produce material which is glassified on its outer surfaces.  Divisional filed as 500282
Patent NZ-333837-A (NZ)
Title: estrene steroids for inducing hypothalamic effects
Inventor: BERLINER DAVID L
IPC: C07J13/00
Filed: 1995-05-29
Abstract: A compound of formula I is claimed wherein: R1 is one or two hydrogens, methyl or one or two halogens R2 is absent or is hydrogen or methyl; R3 is oxo, hydroxy, alkoxy, acyloxy, benzoyl, cypionyl, glucuronide or sulphonyl; R4 is hydrogen, hydroxy, alkoxy, acyloxy, oxo or halogen; R5 is absent or is hydrogen, hydroxy, alkoxy or acyloxy; R6 is hydrogen or halogen; a is an optional aromatic unsaturation of the ring A of the steroid or b, c and d are each optional double bonds; b, e, f, g, h, i and j are each optional double bonds limited by the provisos as listed in the specification.
Patent NZ-333840-A (NZ)
Title: Absorbents containing activated carbons and water-swellable bentonite-containing material for use in animal litter boxes
Inventor: MAXWELL JASON R
IPC: B01J20/20
Filed: 1997-08-05
Abstract: Absorbents containing effective odor absorbing amounts of activated carbon. The activated carbon-containing absorbents may also be formed in conjunction with a wide variety of adsorbent materials including bentonite, opaline silica and the like and are suitable for use as absorbents in a wide variety of absorbent application and are particularly well suited for use as animal litters. Such absorbent may also contain fluoropolymer dedusting agents and bactericides to form unique absorbent compositions with diverse properties and uses.
Patent NZ-335069-A (NZ)
Title: Method and device for synchronously impact milling of material
Inventor: ZANDEN JOHANNES PETRUS ANDREAS VAN DER
IPC: B02C13/18
Filed: 1997-10-10
Abstract: Disclosed is a method for directly and multiply making material collide in an essentially deterministic manner, the material being guided, by a rotating guide member (8) from a central feed, along a guide face (not shown) and to a delivery end (19), in such a guide manner, that the material leaves the guide member, from an essentially predetermined take-off location, at an essentially predetermined take-off angle and at a take-off velocity which can be selected with the aid of the angular velocity, with the instantaneous angle () between the radial line (48) on which the delivery is situated and the radial line (49) on which is situated the location where the spiral stream and the path of the rotating impact member (14) intersect one another being synchronised in such a way that the impact takes place at an essentially predetermined location, at an essentially predetermined impact angle and at an impact velocity which can be selected with the aid of the angular velocity, whereupon the material, when it comes off the impact face, collides with a collision face of a stationary impact member at a collision velocity which is at least as great as the impact velocity.
Patent NZ-503636-A (NZ)
Title: Vaccines for the prevention of clostridial diseases of sheep that provide effective immunity for up to a year or more from a single dose
Inventor: BUCHTA RICHARD
IPC: A61K47/44
Filed: 1998-10-16
Abstract: Described are vaccines suitable for the prevention of Clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single injection or dose. The sheep vaccine composition comprises: an oily adjuvant acceptable for veterinary purposes comprising: i) a white mineral oil having a molecular weight of about 250 to 300 and ii) a mannitol oleate emulsifier and an aqueous phase comprising one or more Clostridial antigens selected from the group consisting of Clostridium periiringens type A, B, C and D, Clostridium septicum, Clostridium tetani, Clostridium chauvoei, Clostridium novyi type B, Clostridium sordelli, Clostridium haemolyticum and Clostridium botulinium C and D.
Patent NZ-507627-A (NZ)
Title: Amidino and guanidino azetidinone derivatives useful as tryptase inhibitors
Inventor: BISACCHI GREGORY
IPC: C07D403/12
Filed: 1999-06-18
Abstract: A beta lactam compounds of formulas (I), (IV) and (V) for use as inhibitors of various enzyme systems including tryptase, thrombin, trypsin, Factor Xa, Factor VIIa and urokinase type-plasminogen activator.
Patent NZ-509299-A (NZ)
Title: 2-substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists
Inventor: ITO FUMITAKA
IPC: C07D401/04
Filed: 1999-07-05
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is unsubstituted, mono-, di- or tri-substituted (C3-C11)cycloalkyl or (C3-C11)cycloalkenyl or the like; A is unsubstituted (C1-C7)alkyl or (C2-C5 )alkenyl, or unsubstituted, mono-, di- or tri-substituted aryl, or aromatic-heterocyclic or the like; Y is hydrogen, halo, amino or mercapto, or unsubstituted, mono-, di- or tri- substituted (C1-C10)alkyl-M-, (C3-C7)cycloalkyl-M-, (C2-C6)alkenyl-M-, (C1-C4)alkyl-NH-(( C1- C4)alkyl)-M-, di(C1-C4)alkyl-N-(( C1- C4)alkyl)-M-, aryl-M-, aromatic or non-aromatic heterocyclic-M-, aryl-( C1- C5)alkyl-M- or aromatic non-aromatic heterocyclic-( C1- C5)alkyl-M-, wherein M is a covalent bond O, S, NH or the like, or the like; Z1, Z2, Z3 and Z4 are independently hydrogen, halo or alkyl, haloalkyl, alkoxy, alkylsulfonyl, alkyl-CO-, carboxy, alkyl-COO-, amino, NH2CO, alkyl-CO-NH, alkyl-SO2-NH-, phenyl or naphthyl. Such compounds have ORL1-receptor agonist activity, and are useful as analgesics or the like in mammalian subjects.