baber/WOPTO huggingface dataset:
Patent EA-021117-B1 (EA)
Title: Method for producing a water-soluble pharmaceutical composition of an antibiotic from the group consisting of rifamycins, and pharmaceutical composition for treating tuberculosis and diseases associated with helicobacter pylori
Inventor: GELPERINA SVETLANA EMMANUILOVNA
IPC: B82B3/00
Filed: 2010-12-27
Abstract: The invention relates to pharmaceutics, in particular, to anti-tubercular medical preparations and methods for production thereof. According to the present invention a method is proposed for producing a water-soluble pharmaceutical composition of an antibiotic from the group consisting of rifamycins as a powder comprising: a) dissolving the antibiotic from the group consisting of rifamycins in an organic solvent selected from a group consisting of ethanol, isopropanol and acetone, b) adding a solution produced in the step a) drop-wise to an aqueous solution of albumin produced by dissolving albumin in a 1-10% molar ratio in a sterilized demineralized water, c) stirring the mixture produced, d) filtering, e) adding a cryoprotector selected from a group consisting of mannitol and trehalose, f) freezing, g) drying (lyophilically or by spray drying). Also proposed is a pharmaceutical composition for the treatment of tuberculosis and diseases specified by Helicobacter pylori persistence in a patient's organism, comprising an antibiotic powder from a rifamycin group obtained by the method of any of claims 1, 2, forming a stable suspension acceptable for intravenous introduction to a patient in need, when adding a pharmaceutically acceptable diluent and/or carrier, characterized in that the powder and the suspension which is formed therefrom when adding the pharmaceutically acceptable diluent and/or carrier, is characterised by average particle size ranging from 100 to 800 nm and from 5 to 80 nm when diluting it by 100 times. The technical result provides elimination of after amounts of methylenechloride, simplification of medical preparation technology.
Patent EA-015478-B1 (EA)
Title: INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17-ACETOXY-11β-[4-(DIMETHYLAMINO)PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS
Inventor: BODI JOZSEF
IPC: C07J21/00
Filed: 2008-06-19
Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11β-[4-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-etandiyl-bis(oxy)]oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones. The process according to the invention is the following: i) formation of an epoxide on the double bond in position 5(10) of 3,3-[1,2-ethandiyl-bis(oxy)]oestr-5(10),9(11)-dien-17-one of formula (II) with hydrogen peroxide; ii) addition of hydrogen cyanide formed in situ on position 17 of the obtained 5,10α-epoxy-3,3-[1,2-ethandiyl-bis(oxy)]-5α-oestr-9(11)-en-17-one of formula (III); iii) silylation of the hydroxyl group in position 17 of the formed 5,10α-epoxy-3,3-[1,2-ethandiyl-bis(oxy)]-17α-hydroxy-5α-oestr-9(11)-en-17β-carbonitrile of formula (IV) with trimethyl chlorosilane; iv) reacting the obtained 5,10α-epoxy-3,3-[1,2-ethandiyl-bis(oxy)]-17-[trimethylsilyl-oxy]-5α-oestr-9(11)-en-17β-carbonitrile of formula (V) with 4-(dimethylamino)phenyl magnesium bromide Grignard reagent in the presence of CuCl (Teutsch reaction); v) silylation of the hydroxyl group in position 5 of the formed 11β-[4-(dimethylamino)phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5-hydroxy-17α-[trimethylsilyl(oxy)]-5α-oestr-9-en-17β-carbonitrile of formula (VI) with trimethyl chlorosilane; vi) reacting the obtained 11β-[4-(dimethylamino)phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[trimethylsilyl(oxy)]-5α-oestr-9-en-17β-carbonitrile of formula (VII) with diisobutyl aluminum hydride and after addition of acid to the reaction mixture; vii) methoxy-methylation of the obtained 11β-[4-(dimethylamino)phenyl]-3,3-[1,2-ethandiyl-bis(oxy)]-5,17α-bis-[trimethylsilyl(oxy)]-5α-oestr-9-en-17β-carbaldehide of formula (VIII) with methoxy-methyl Grignard reagent formed in situ, while hydrolyzing the trimethylsilyl protective groups; viii) oxidation of the hydroxyl group in position 20 of the obtained 17,20ξ-dihydroxy-11β-[4-(dimemylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3-one of formula (IX) with dicyclohexyl carbodiimide in the presence of dimethyl sulfoxide and a strong organic acid (Swern oxidation), and in given case after purification by chromatography; ix) acetylation of the hydroxyl group in position 17 of the obtained 11β-[4-(dimethylamino)phenyl]-17-hydroxy-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (X) with acetic anhydride in the presence of perchloric acid, and in given case the obtained 7-acetoxy-11β-[4-(dimethylamino)phenyl)]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I) is purified by chromatography. The invention also relates to the new intermediates of formula (VII) and (VIII).
Patent EA-018955-B1 (EA)
Title: Road structure on low-load-bearing soils (variants)
Inventor: PROKHORENKOV ALEKSEY VIKTOROVICH
IPC: E01C3/04
Filed: 2008-05-27
Abstract: The invention relates to construction and is used for building roads on low-load-bearing soils. The inventive road structure on low-load-bearing soils comprises earth reinforced by one or more layers of brushwood pavement which is overlapped at a sharp angle to the road axis. The edges of the traffic area and/or the roadsides are reinforced by an addition brushwood pavement layer which is overlapped at an angle equal to or less than 15° to the road axis. The addition brushwood pavement layer is interlaced with at least one brushwood pavement layer. When the brushwood pavement consists of more than one layers, said layers are interlaced at the edges of the traffic area and/or the roadsides. In each pavement layer, the brushwood is arranged by alternating the direction of the brushwood stem placing in a "butt-to-top" manner. According to a second variant, the road structure on low-load-bearing soils comprises earth reinforced by one or more layers of brushwood pavement which are laid in a pre-excavated bed, the width of which is equal to the width of the traffic area, and the compressed earth extracted during the bed excavation is placed on the top of the brushwood pavement. Furthermore, the traffic area, the edges and the roadsides are reinforced in the first variant manner. The invention makes it possible to increase the reliability and the service life of the road structure and to use heavy transportation means thereon.
Patent EA-023856-B1 (EA)
Title: Clamp fastener
Inventor: NURMINEN ARI
IPC: F16B2/24
Filed: 2011-11-28
Abstract: The invention relates to a clamp fastener (1) for fastening an accessory detachably and adjustably by position to a suitable fastening support (2). Said clamp fastener (1) includes a shaft (3) that is supported to the fastening support (2); a clamp (4) including two adjacent plier elements, a first and a second plier element (41, 42), a gap (43) between the plier elements and a first spring element (44); in which gap (43) there is arranged a channel (5) for the support bar (T) of an accessory in order to fasten said accessory to the clamp and to the clamp fastener; first and second gear ring elements (6; 61, 62) arranged in a mutually matching position; a second spring element (7; 71) between the gear rings (6; 61, 62); and a clamp actuator (8). The clamp (4), gear ring elements (6; 61, 62) and the second spring element (7; 71) are fitted in the intermediate space (23) of the fastening support and interconnected by a shaft (3) passing at right angles through their center area, and at the first end (31) of said shaft (3), outside the fastening support (2), there is attached a clamp actuator (8) for pressing the plier elements (41, 42) of the clamp (4) together, and respectively for opening them in order to fasten the support bar (T) in a channel (5) and respectively for releasing it from the channel (5). According to the invention, the shaft (3) is in the region of the clamp (4) and is provided with two shoulders (33, 34) spaced apart at a distance (a), the first (33) of said shoulders being arranged outside the clamp (4), towards the outer surface (41b) of the first plier element (41), and the second (34) of said shoulders being arranged inside the clamp, towards the inner surface (42a) of the second plier element (42), so that in between said second plier element (42) and the fastening support (2) there are located the gear ring elements (6; 61, 62) fitted in a mutually facing position, and the second spring element (7; 71), the distance (a) between the shoulders (33, 34) being shorter than the added length of the diameter (b) of the gap (43) of the clamp (4) in the rest position and the thickness (c) of the first plier element (41).
Patent EA-023470-B1 (EA)
Title: Novel formulations which stabilize immunogenic compositions and inhibit precipitation thereof
Inventor: KHANDKE LAKSHMI
IPC: C07K14/345
Filed: 2007-04-19
Abstract: The invention addresses an ongoing need in the art for formulations which improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
Patent EA-022289-B1 (EA)
Title: N1-sulfonyl-5-fluoropyrimidinone derivatives
Inventor: BOEBEL TIMOTHY
IPC: C07D339/02
Filed: 2010-08-05
Abstract: This present disclosure is related to the field of N1-sulfonyl-5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.
Patent EA-024861-B1 (EA)
Title: Method and device for controlling an atmospheric boiler with an air tight combustion chamber
Inventor: BERTELLI PIERLUIGI
IPC: F23N5/12
Filed: 2010-03-24
Abstract: A method of controlling a boiler provided with atmospheric burner and comprising a valve for controlling the gas sent to a burner (14), means (10) for detecting the flame present in the latter and control means (13) of functional components of the boiler such as the gas valve (15), a fan, provided with its own electric motor, a circulator o pump, a temperature probe, said control means (13) co-operating with a memory (12) wherein a plurality of optimum operating conditions of the boiler is tabulated functions of features related to the flame, to the thermal power and to the value lambda. The working point of the boiler is determined on one of such curves, the ratio between combustion air and gas is modified starting from a current operating value, in order to shift such working point along such curve, it is verified if such variation of the ratio arrives at a predefined value and in that case a previous air-gas ratio of correct operation is reset, in the opposite case the gas flow rate being modified in order to obtain an optimum combustion ratio. A device is also claimed for accomplishing such method.
Patent EA-025690-B1 (EA)
Title: Wound healing agent possessing immunostimulatory and antioxidant effects
Inventor: KOROSHVILI VADIM TEJMURAZOVICH
IPC: A61P39/06
Filed: 2014-07-15
Abstract: The invention is related to medicine (traumatology, surgery) and veterinary and can be used for stimulation of skin wound healing. The invention consists in use of a peptide of a formula HN-D-Ala-L-Glu-L-Trp-COOH differing from timogen HN-L-Glu-L-Trp-COOH in the presence of an additional amino acid (D-alanine) near the N-end of the peptide. Peptide was administered once a day parenterally (intraperitoneally or intracutaneously) in a single dose equimolar with timogen (HN-D-Ala-L-Glu-L-Trp-COOH - 1,2 μg/kg, timogen - 1 μg/kg of body weight). In case of parenteral administration of the peptide during 10 days from the moment of appearance of a skin wound, the experimental animals (Wistar rats) showed stimulation of reparative skin regeneration (the number of fibroblasts increased) and activation of blood neutrophil function. Further, in such conditions, the peptide HN-D-Ala-L-Glu-L-Trp-COOH had an antioxidant effect, which was confirmed by an increase in superoxide dismutase activity after intraperitoneal and intracutaneous administration, also the level of malon dialdehyde lowered after intracutaneous administration of the peptide. Thus, the synthetic peptide of general formula HN-D-Ala-L-Glu-L-Trp-COOH can be used as an agent stimulating healing of skin wounds, immune and oxidant protection of an organism.
Patent EA-030040-B1 (EA)
Title: Improved absorbable cap for bladder enlargement in patients with low compliance or for the replacement of a vast portion of bladder following bilharzia
Inventor: SAMBUSSETI ANTONIO
IPC: A61L27/58
Filed: 2013-03-06
Abstract: A description is given of a domed cap (100) for the enlargement of an atrophied bladder (200), in biocompatible and absorbable material comprising a textile (1) made with yarns or with monofilaments deriving from PGA fibres, characterised in that said textile (1) is supported by a star-shaped frame with domed profile, formed by a plurality of radial strips (3) manufactured by injection of a PGA/PLA copolymer, said cap (100) being suitable for growing thereon autologous fibrous capsule cells, generated by the process of tissue reconstruction, after its insertion inside the patient.
Patent EA-027203-B1 (EA)
Title: Driving and controlling method for biomimetic fish and biomimetic fish
Inventor: LU XIAOPING
IPC: B63H1/36
Filed: 2012-07-09
Abstract: An aquatic toy that is a biomimetic fish with a watertight body portion. The body portion contains a battery electrically connected via a controller to at least one coil. The coil is positioned relative to a magnet and the coil can be caused to oscillate by virtue of a controller defined alternating current passing through the coil. The oscillation of the coil causes movement of a tail fin that is engaged to said watertight body to cause the fish to move forward through a body of water.
Patent EA-034654-B1 (EA)
Title: Use of bovine milk osteopontin for enhancing immune resistance
Inventor: KVISTGAARD ANNE STAUDT
IPC: A61K38/17
Filed: 2014-07-04
Abstract: The invention provides the use of a bovine milk osteopontin and/or an active truncation or active peptide thereof for enhancing immune resistance to an infectious disease in a mammal belonging to an age group 0-6 months. The invention also provides the use of a kit comprising a vaccine and a bovine milk osteopontin for enhancing immune resistance to a vaccine-induced infectious disease in a mammal belonging to an age group 0-6 months, wherein the bovine milk osteopontin and/or one or more of truncations thereof are/is provided for oral administration.
Patent EA-031542-B1 (EA)
Title: Method for managing the power output of a photovoltaic cell (embodiments)
Inventor: MCNAMARA ROBERT P
IPC: H02S40/32
Filed: 2015-02-21
Abstract: The invention relates to a solar cell management system for increasing the efficiency and power output of a solar cell and methods for making and using the same. The management system provides an electric field across an individual solar cell, an array of solar cells configured as a panel, or a group of solar panels. The imposed electric field exerts a force on both the electrons and holes created by light incident on the solar cell and accelerates the electron-hole pairs towards the electrodes of the solar cell. Compared to conventional solar cells, these accelerated electron-hole pairs travel a shorter distance from creation and spend less time within the solar cell material, therefore the electron-hole pairs have a lower likelihood of recombining within the cells' semiconductor's material. This reduction in the electron-hole recombination rate results in an overall increase in the solar cells' efficiency and greater power output.
Patent EA-032116-B1 (EA)
Title: New use of n,n-bis-2-mercaptoethyl isophthalamide
Inventor: HALEY BOYD EUGENE
IPC: A61P31/00
Filed: 2015-03-31
Abstract: According to the invention there is provided N,N-bis-2-mercaptoethyl isophthalamide, or pharmaceutically acceptable salts or derivatives thereof, for use in regenerating ascorbate systemically and thus in the therapeutic treatment of a chronic obstructive pulmonary disease.
Patent EA-033133-B1 (EA)
Title: Device for feeding liquefied gas into priming apparatus of an internal combustion engine
Inventor: KIRICHENKO ALEXEY ANATOLIEVICH
IPC: F04D3/02
Filed: 2016-11-17
Abstract: The technical solution relates to devices for feeding liquified petroleum gas (e.g., propane) into the internal combustion engine (ICE) and may be used in automotive engineering. The objective of the claimed technical solution consists in higher performance characteristics, namely, reliability and durability. The objective is achieved by a device for feeding liquified gas into priming apparatus of an internal combustion engine comprising a gas storage vessel and a pumping unit whose outlet is connected via a gas feeding line to the internal combustion engine inlet collector through a fuel frame and nozzles, and the pumping unit has a leak-proof cylindrical body with inlet and outlet holes, and its cavity accommodates a screw pump with an electrical motor, and the cylindrical body inlet hole is connected to the gas feeding line from the gas storage vessel; according to the invention, the device further comprises a magnetic filter installed in the pumping unit cavity, electrical engine armature metal (copper) lamella surface that has no contact with the stator brushes, and the gaps between the lamella are coated with an electrical insulation protective layer, e.g., of epoxy resin or varnish, the screw pump casing is made of hard anti-friction material, e.g. metal ceramics, and the magnetic filter represents an external steel cylinder in whose cavity an internal cylinder with hoes on its side surface is coaxially mounted, and between the cylinders three horizontal layers are disposed in the following sequence: first filtering disk, magnetic disk, second filtering disk; the filtering disks are filled with steel fibers located parallel to the magnetic disk surface.
Patent EA-036401-B1 (EA)
Title: Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from c6 and c5 sugars
Inventor: TAARNING ESBEN
IPC: C07C69/732
Filed: 2016-06-20
Abstract: The invention relates to a process for the preparation of alpha-hydroxy-beta-ene-acids or esters thereof, particularly to the preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof of the formulawherein the meanings of R and R' are defined in the specification, the process comprising the steps of: a. contacting a saccharide composition comprising one or more C6 and/or C5 saccharide units with a Lewis acid material; and b. recovering 2,5,6-trihydroxy-3-hexenoic acid and/or 2,5-dihydroxy-3-pentenoic acid or esters thereof; wherein said saccharide composition comprising one or more C6 and/or C5 saccharide units is selected from the group consisting of sucrose, xylose, mannose, taga tose, galactose, glucose, fructose, arabinose, inulin, amylopectin and sugar syrup, and wherein the concentration of alkali metal ions in the Lewis acid material is maintained at the level of concentration less than 0.13 mM or amount less than 0.5 wt.% of the weight of the Lewis acid material.
Patent ES-2165303-B1 (ES)
Title: Composicion de un producto alimenticio para reposteria.
Inventor: COLLADA BARCENA CARLOS
IPC: A21D13/80
Filed: 2000-02-04
Granted: 2003-05-16
Abstract: Composición de un producto alimenticio para repostería; cuyo producto se constituye por un relleno y una cubierta y que comprende: azúcar 24% en peso. Jarabe de azúcar 24,65% en peso. Pulpa de manzana 36,50% en peso y harina de almendra 14,85% en peso.
Patent ES-2177463-B1 (ES)
Inventor: AVELLANAS CHAVALA MANUEL LUIS
IPC: A61G1/048
Filed: 2001-04-10
Granted: 2003-12-16
Abstract: Rescue stretcher, designed for all types of rescue operations in high and middle mountains and ravines. The stretcher is characterized in that it is formed by a base or structure (1), which can be folded and separated into two different parts. It is fitted with protective elements for the head and feet areas and handles for manual transportation; an insulation blanket (2) that can be separated into independent parts; a fixing harness (3), horns (4) to carry the assembly on the shoulders and a protective and immobilizing element for the head (5). <IMAGE>
Patent ES-2197789-B1 (ES)
Title: Mejora de una bomba vibratoria.
Inventor: PASTORI AURELIO ANTONIO
IPC: F04B47/06
Filed: 2000-06-14
Granted: 2005-02-16
Abstract: El presente resumen se refiere a una solicitud de patente pionera por una bomba vibratoria que pertenece al campo del equipamiento hidráulico y que está provista de un diámentro menor que el diámetro normalmente pbservado, apropiado para alojar la bomba dentro de un pozo tubular; dicha bomba está aún provista de un dispositivo de refrigeración del conjunto de solenoide de accionamiento (10) y consiste en invertir la posición de los mecanismos de tal manera que el solenoide (10) mencionado esté situado en la región superior de la bomba y aloiado dentro del vaso tubular invertido (40); y el miembro de transmisión (20) sujeto al solenoide (10), el conjunto de bombeo (30) sujeto al miembro de transmisión (20) y las entradas de agua (38) estén colocados en la región inferior de la bomba; dicho vaso tubular invertido (40) define un paso anular (41) con respecto a la pared del bastidor (1), cuyo extremo superior comunica con la salida superior de bombeo (2) del bastidor (1), en tanto que el extremo inferior de dicho paso (41) comunica con las salidas de bombeo (33) que comunican con la cámara de bombeo auxiliar (32) del conjunto de bombeo (30); la bomba mencionada puede utilizarse con o sin accesorios auxiliares, propiciando éstos que la misma se convierta en una bomba aspirante o que se componga un conjunto de bombas en serie.
Patent ES-2211285-B1 (ES)
Title: Procedimiento e instalacion para el llenado de botellas con gas.
Inventor: SAURA NOGUERA PEDRO
IPC: F17C5/00
Filed: 2002-05-16
Granted: 2005-03-16
Abstract: Procedimiento e instalación para el llenado de botellas con gas. Se caracteriza por el hecho de que la instalación comprende una volteadora (1) en la cual están dispuestas las botellas (2, 3, 4), un accionador que provoca el giro de la volteadora (1), un circuito neumático que comunica las citadas botellas (2, 3, 4) a un depósito de gas, medios neumáticos (7 a 21) dispuestos en dicho circuito para la realización de las operaciones de venteo, lavado, vacío y llenado, y medios de control que actúan sobre el accionador y sobre los medios neumáticos (7 a 21) de manera que permiten gobernar dichas operaciones de un modo automático. El llenado con gas de las botellas se controla mediante un caudalímetro másico. Se consigue realizar la dosificación del gas en las botellas sin desmontarlas de la volteadora, reduciéndose así el número de operaciones a realizar para cada botella, y garantizándose la calidad del gas envasado.