Patent SG-11201807003U-A (SG)
Title: Smc combination therapy for the treatment of cancer
Inventor: KORNELUK ROBERT G
IPC: C07K5/062
Filed: 2017-02-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111010111111111011111101111101111011111 International Bureau ... ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/143449 Al 31 August 2017 (31.08.2017) WIPO I P CT (51) International Patent Classification: (74) Agent: SMART & BIGGAR; 2300-1055 West Georgia A61K 38/05 (2006.01) A61P 35/00 (2006.01) Street, PO Box 11115, Vancouver, British Columbia V6E A61K 35/76 (2015.01) C07K 5/062 (2006.01) 3P3 (CA). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/CA2017/050237 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, 23 February 2017 (23.02.2017) DO, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/299,288 24 February 2016 (24.02.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant . CHILDREN'S HOSPITAL OF EASTERN ZA, ZM, ZW. ONTARIO RESEARCH INSTITUTE INC. [CA/CA]; 401 Smyth Road, Ottawa, Ontario K1H 8L1 (CA). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: KORNELUK, Robert G.; 1901 Tweed Aven- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, ue, Ottawa, Ontario K1G 2L8 (CA). LACASSE, Eric C.; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 1727 Featherston Drive, Ottawa, Ontario K1H 6P3 (CA). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, BEUG, Shawn T.; 1786 Calumet Lane, Ottawa, Ontario DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, K1C 1V9 (CA). TANG, Vera A.; 200 Besserer Street, LV, Apt. 1109, Ottawa, Ontario K1N 0A7 (CA). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = [Continued on next page] (54) Title: SMC COMBINATION THERAPY FOR THE TREATMENT OF CANCER FIG. 34 - NI iz,,,:i. , : (57) : The present invention includes methods and compositions for enhancing the efficacy of SMCs in the treatment of cancer. In particular, the present invention includes methods and compositions for combination therapies that include an SMC and at least a second agent that stimulates one or more apoptotic or immune pathways. ,t The second agent may be, e.g., an im- munostimulatory or immunomodulat- ory compound or oncolytic virus. 1-1 C:7 7r M 7r 11 IN 11 © ei O WO 2017/143449 Al 1#110H011010EIR010130101111111011110111 0V0IS SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Published: GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3)) Declarations under Rule 4.17: — before the expiration of the time limit for amending the — as to applicant's entitlement to apply for a patent (Rule 4.1700) — as to the applicant's entitlement to claim the earlier application (Rule 4.17(iii)) and the be granted priority of claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of