baber/WOPTO huggingface dataset:
Patent EP-3775206-A1 (EP)
Inventor: DUVAL ALEX
IPC: A61K31/7088
Filed: 2019-03-27
Abstract: The invention relates to method for treating cancer. Through whole exome sequencing, the inventors analyzed 47 MSI CRC and results were confirmed in a series of 53 MSI CRC. Negatively selected coding alterations in MSI CRC were further investigated for their functional role in CRC cell lines and survival impact in a cohort of 164 MSI CRC patients. Five coding negatively selected, MSI-related mutational events were demonstrated to have deleterious effects on tumor expansion, while they were associated with worse prognosis in patients. The inventors investigated the functional consequences of the silencing of WNK1, HMGXB4, GART, RFC3 and/or PRRC2C using siRNA and/or shRNA in CRC cell lines in vitro and in vivo using xenograft models. Their inactivation in CRC cells led to deleterious effects on apoptosis, proliferation and/or cell migration. The deleterious effects were greatly enhanced when several of the targets were concomitantly silenced. The prolonged silencing of these targets led to strong inhibition of tumor growth in HCT116 (MSI) and/or SW480 (MSS) xenografts. Thus, the invention relates to a compound selected from WNK1 inhibitor, HMGXB4 inhibitor, GART inhibitor, RFC3 inhibitor and/or PRRC2C inhibitor for use in the treatment of cancer, MSS CRC and MSI CRC.
Patent EP-3756379-A1 (EP)
Inventor: GUNNARSSON FREDRIK
IPC: H04W24/10
Filed: 2019-02-20
Abstract: Systems and methods for System Frame Number (SFN) Frame Time Difference (SFTD) reporting are disclosed. Embodiments of a method of operation of a User Equipment (UE) in a wireless network to perform SFTD measurements between a Primary Cell (PCell) of the UE and one or more other cells is provided. In some embodiments, the method comprises receiving, from a network node in the wireless network, a list of cells for which the UE can report SFTD measurements. The method further comprises performing SFTD measurements and reporting the SFTD measurements in accordance with the list of cells for which the UE can report SFTD measurements. In this manner, SFTD reporting is provided in an efficient manner.
Patent EP-3763024-A1 (EP)
Inventor: WOLFRAM ROUVEN
IPC: H02K7/102
Filed: 2019-04-10
Abstract: The invention relates to an electric motor, wherein the electric motor has an end shield (5), wherein the electric motor has a sensor (7) for detecting a magnetic field. The sensor (7) is integrated into the end shield (5) of the electric motor. The invention also relates to an electric drive unit (1) comprising a brake (3), in particular an electromagnetically actuatable brake (3), and an electric motor, wherein a shielding element (8) is arranged between the sensor (7) and the brake (3).
Patent EP-3790413-A1 (EP)
Inventor: JENNEWEIN STEFAN
IPC: C12P19/14
Filed: 2019-05-06
Abstract: Provided is a method for the purification of lacto- N - neo tetraose from other carbohydrates, characterized in that the method comprises the steps of subjecting an aqueous solution containing lacto- N - neo tetraose to two membrane filtration steps using different membranes or of subjecting an aqueous solution containing lacto- N - neo tetraose to a membrane filtration step and a continuous chromatography.
Patent EP-3777423-A1 (EP)
Inventor: FAKOORIAN SEYED ALI AKBAR
IPC: H04W72/12
Filed: 2019-04-12
Abstract: Some wireless communications systems may support different types of communications between base stations and user equipment (UEs), such as mobile broadband (MBB) communications and low latency communications. Low latency communications may be associated with bursty and unpredictable transmissions. As described herein, to facilitate low latency communications and limit the latency associated with waiting on appropriate resources for transmitting low latency data, a base station may schedule downlink low latency transmissions on uplink resources or uplink low latency transmissions on downlink resources. Further, to limit the latency associated with scheduling low latency communications, a base station may be configured with a carrier for transmitting preemption indications (PIs) to one or more UEs to reassign resources for low latency communications. Similarly, in some cases, a UE may be configured with a carrier to transmit scheduling requests (SRs) to request resources for low latency communications.
Patent EP-3775284-A1 (EP)
Inventor: HOWELL MICHAEL D
IPC: C12Q1/6883
Filed: 2019-03-29
Abstract: L'invention concerne des biomarqueurs qui sont prédictifs de la réactivité d'un sujet à une thérapie comprenant un inhibiteur de JAK. Les biomarqueurs, compositions et procédés décrits ici sont utiles dans la sélection de modalités de traitement appropriées pour un sujet ayant, suspecté d'avoir, ou risquant de développer une maladie cutanée inflammatoire.
Patent EP-3729573-A1 (EP)
Title: A laser system providing a shaped intensity profile of an output beam within an unstable optical resonator layout and method thereof
Inventor: KÖRNER JÖRG
IPC: H01S3/115
Filed: 2019-05-17
Abstract: The present invention relates to a laser system and a method of generating a defined spatial mode-shaped laser beam using an unstable laser resonator layout. The laser system for mode shaping of a laser beam (7) within an unstable optical resonator layout comprising an active medium (3), characterized in that, the active media (3) comprises a pumped area (4), wherein the gain distribution is generated by an optical pump beam's spatially intensity profile. In a preferred embodiment, the system may further comprise an end-pumped layout to deliver the spatially shaped optical pump beam (6) to the active medium (3); and/or an active element and/or a passive element for modifying the resonator losses; and/or means of output coupling of a laser beam from said unstable resonator layout. The system according to the present invention is suitable to deliver a top-hat beam profile.
Patent EP-3802386-A1 (EP)
Title: Douille, équipement d'enroulement et procédé destiné à enrouler plusieurs fois les unes sur les autres des bandes en enroulements de matériau
Inventor: SUNDERMANN FABIAN
IPC: B65H19/30
Filed: 2019-05-24
Abstract: L'invention décrit une douille destinée à être poussée sur un arbre d'enroulement et à être retirée d'un arbre d'enroulement, laquelle comprend une pièce à usiner monolithique décrivant un cylindre, laquelle comprend deux zones de rebords pourvues chacune d'un rebord, les zones de rebords se chevauchant, la douille comportant un premier diamètre dans un état desserré, la douille comportant, dans un état serré, un deuxième diamètre, lequel s'écarte du premier diamètre la douille subissant une déformation élastique à l'état serré en comparaison à l'état desserré.
Patent EP-3796912-A1 (EP)
Inventor: PIERCE DANIEL W
IPC: A61P35/00
Filed: 2019-05-22
Abstract: La présente invention concerne des méthodes d'utilisation de 4-(4-(4-(((2-(2,6-dioxopipéridin-3-yl)-1-oxoisoindolin-4-yl)oxy)méthyl)benzyl)pipérazin-1-yl)-3-fluorobenzonitrile, ou d'un énantiomère, d'un mélange d'énantiomères, d'un tautomère, ou de son sel pharmaceutiquement acceptable et d'un anticorps bispécifique se liant spécifiquement à l'antigène de maturation des lymphocytes B humains (BCMA) et au CD3e humain (CD3) décrit dans la description, dans le traitement, la prévention ou la gestion du myélome multiple.
Patent EP-3827014-A1 (EP)
Inventor: SAHIN UGUR
IPC: A61K39/39
Filed: 2019-07-19
Abstract: The invention relates to variants of interleukin-2 (IL2). In one embodiment, the IL2 variants activate effector T cells over regulatory T cells. In particular, the invention relates to a polypeptide comprising a mutein of human IL2 or of a functional variant of human IL2, wherein the human IL2 or functional variant thereof is substituted at at least a position having an acidic or basic amino acid residue in wild type human IL2 that contacts the alpha subunit of the αβγ IL2 receptor complex (Ι12Καβγ). Alternatively, the mutein of human IL2 or of a functional variant of human IL2 comprises at least (i) one or more amino acid substitutions which reduce the affinity for the alpha subunit of ΙΙ_2Καβγ and (ii) one or more amino acid substitutions which enhance the affinity for ΙΙ_2Κβγ. The invention also relates to polynucleotides coding for the polypeptides of the invention, host cells comprising the polynucleotides, pharmaceutical compositions comprising the polypeptides, polynucleotides or host cells, therapeutic or prophylactic methods of treatment using the polypeptides, polynucleotides, host cells or pharmaceutical compositions and medical preparations comprising the polypeptides, polynucleotides, host cells or pharmaceutical compositions.
Patent EP-3824253-A1 (EP)
Title: Flowmeter having an adjustable shield with flow scales
Inventor: VAN VOORST JAN WILLEM
IPC: G01F25/00
Filed: 2019-07-12
Abstract: A flowmeter having an adjustable protective shield for calibrating the flowmeter is presented. The flowmeter includes an inner conduit providing a flow path for pressurized fluid, a protective shield having a plurality of markers providing a visible indicator of the flow rate of the pressurized fluid according to the position of the float in the flow path, and a housing assembly for receiving the inner conduit and the protective shield. The flowmeter also can include a fitting assembly for securely coupling the inner conduit, the flow label, and the housing assembly in-line within a pipeline path. The flowmeter can be calibrated by adjusting the position of the protective shield while in-line within the pipeline path.
Patent EP-3824091-A1 (EP)
Title: Devices and methods for mitochondria replacement and for generating cellular therapeutics
Inventor: WU TING-HSIANG SHERRY
IPC: C12N15/87
Filed: 2019-07-19
Abstract: Devices and methods are presented for delivery of various macrostructures into cells, such as depleted cells as well as methods of generating engineered cells using said devices and methods. Cells are placed on a porous membrane. A force is applied by a configurable actuator to a deformable fluid reservoir that generates an applied pressure to macrostructures in a solution, causing the macrostructures to pass through the porous membrane and triggering uptake of at least some of the macrostructures into the cells to form transfected cells. Said devices and methods may be used in a process to replace defective endogenous mtDNA with corrected mtDNA to generate cellular-based therapeutics for administration to a patient. The customizable actuator may be configured with parameters to optimize efficiency for a given cell type and material to be transfected. Machine learning techniques also may be utilized to optimize transfection parameters.
Patent EP-3751955-A1 (EP)
Title: Method for activating packet data convergence protocol (pdcp) repetition mechanism and node device
Inventor: LIU AIJUAN
IPC: H04W80/02
Filed: 2019-02-01
Abstract: The present disclosure provides a method for activating a packet data convergence protocol (PDCP) duplication and a node device. The method includes: receiving, by a second node, a notification message transmitted by a first node when the first node configures a PDCP duplication for a bearer; after the second node receives the notification message, changing or determining, by the second node, an activation or deactivation state of uplink (UL) PDCP duplication of the bearer.
Patent EP-3834208-A1 (EP)
Title: Method and system for assessing emergency risk for patients
Inventor: WEFFERS-ALBU MIRELA ALINA
IPC: G16H50/30
Filed: 2019-08-02
Abstract: A system for assessing emergency risk of patients in an emergency department is provided. The system includes a patient carrier comprising a transmissive structure, one or more optical or radar sensors configured to measure respiration information of the patient via light or radio waves traveling through at least a portion of the transmissive structure of the patient carrier, one or more additional sensors configured to measure injury information and cardiac information of the patient, and a computer system comprising one or more physical processors that are programmed with computer program instructions that, when executed cause the computer system to: determine an emergency risk parameter for the patient based on the cardiac information, the injury information and the respiration information of the patient obtained from the one or more sensors. The emergency risk parameter for the patient indicates that the patient requires medical intervention within a specified time period..
Patent EP-3811435-A1 (EP)
Title: Batteriekasten mit verstärkungselement
Inventor: SCHMIDT WERNER
IPC: B60K1/04
Filed: 2019-08-01
Abstract: Die Erfindung betrifft einen Batteriekasten für ein Kraftfahrzeug zur Aufnahme von Batteriezellen mit einem Strukturrahmen mit wenigstens zwei endseitig aneinander gefügten Strukturbauteilen. Jedes Strukturbauteil weist wenigstens ein teilweise hohl ausgebildetes und im Querschnitt im Wesentlichen L-förmiges Profilsegment auf. Innerhalb wenigstens eines der Profilsegmente ist ein Verstärkungselement zur Aufnahme von Aufprallenergie bei einem Aufprall angeordnet. Das Verstärkungselement ist ein Formteil mit einer Mehrzahl von offenen Zellen, die aneinander angrenzend und mit ihrer Längserstreckung im Wesentlichen parallel zueinander angeordnet sind. Im montierten Zustand des Batteriekastens im Kraftfahrzeug sind die offenen Zellen mit ihrer Längserstreckung im Wesentlichen parallel zur Fahrzeugquerrichtung ausgerichtet.
Patent EP-3763712-A1 (EP)
Inventor: CHEN XUXING
IPC: A61K31/5377
Filed: 2019-03-05
Abstract: The invention provides an indolizine compound represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method and a use thereof. The indolizine compound has an inhibitory effect on wild-type and/or mutant EZH2 or EZH1, and is expected to be developed into a novel drug for anti-tumor or for the treatment of autoimmune diseases.
Patent EP-3761977-A1 (EP)
Inventor: MACK RANDALL J
IPC: A61K31/4196
Filed: 2019-03-08
Abstract: The present disclosure relates to meloxicam bolus formulations and methods of administering the same intravenously, for treatment of pain, which can provide fast onset of pain relief suitable for management of acute moderate to severe pain.
Patent EP-3762674-A1 (EP)
Inventor: MASARIK DAVID MICHAEL
IPC: F41A9/62
Filed: 2019-03-08
Abstract: A linear encoder may be used to accurately determine a number of cartridges within a magazine. Further, using a set of magnetic sensors within a buffer tube of a firearm, it is possible to determine whether a cartridge is loaded within a chamber of the weapon and/or whether the firearm is jammed. The determination of cartridges within the magazine in conjunction with the determination of whether a cartridge is in a chamber of a firearm can give a user an accurate ammunition count. Further, the use of the linear encoder makes it possible to accurately determine the cartridge count when different cartridges are loaded into the magazine or when the magazine degrades in quality over time. Moreover, the ability for magazines to communicate with a firearm enables a user to determine a total available ammunition to the user in a single display without individually checking each magazine.
Patent EP-3766001-A1 (EP)
Title: Fingerprint sensing arrangement and a method for filtering a fingerprint pattern signal
Inventor: CHRISTENSEN LARS
IPC: G06V10/36
Filed: 2019-03-04
Abstract: The present invention relates to providing a filtered fingerprint pattern signal indicative of a fingerprint pattern with a fingerprint sensing device comprising an array of sensing elements for sensing the fingerprint pattern.Each sensing element is configured to provide a sensing signal indicative of a local fingerprint pattern feature. The method comprises: receiving analog sensing signals from each of a set of sensing elements comprising at least four sensing elements, filtering the set of sensing signals to provide a set of filtered output signals each comprising a linear combination of the set of sensing signals in which each sensing signal has a respective coefficient. The coefficients in each linear combination sum up to zero, and wherein the linear combinations are different from each other. The set of filtered output signals are converted to a filtered digital sensing signal indicative of the user's fingerprint pattern.
Patent EP-3778834-A1 (EP)
Title: Lubricating oil base oil, lubricating oil composition containing same, and continuously variable transmission using said lubricating oil composition
Inventor: OGATA KENICHI
IPC: C10N30/00
Filed: 2019-03-27
Abstract: Provided are: a lubricant base oil capable of achieving both a high traction coefficient and an excellent low-temperature fluidity at a higher level and having a high flash point, which contains a ring-containing compound having at least (i) a crosslinked bicyclic ring where two rings are bonded while sharing 3 or more carbon atoms, and (ii) an acyloxy group or a hydrocarbyloxycarbonyl group each containing a branched hydrocarbon group with a main chain having 4 or more carbon atoms, a lubricating oil composition containing the lubricant base oil, and a continuously variable transmission using the lubricating oil composition.
Patent EP-3778728-A1 (EP)
Inventor: ICHIKI Toshiya
IPC: C08J5/18
Filed: 2019-03-28
Abstract: A highly transparent water-soluble film is provided. The water-soluble film contains a PVA resin as a major component, and has not more than 50 dark defects each having a diameter of 1 to 5 mm per a 5 cm × 5 cm area thereof as observed under crossed Nicols after being uniaxially stretched under the following conditions (α): 
(α) a test piece cut out of the water-soluble film to a size having a length of 25 cm and a width of 13 cm is clamped with chucks spaced 11 cm from each other longitudinally of the test piece in a stretching machine, and is uniaxially stretched at a stretching rate of 3 mm/second to a stretch ratio of 1.2 at a temperature of 23°C at a humidity of 50%RH.
Patent EP-3817809-A1 (EP)
IPC: A61N5/10
Filed: 2019-09-27
Abstract: According to the present invention, an initial, i.e. a first, packed arc setup is compared with predefined arc setup constraints. These predefined arc setup constraints at least constrain the number of patient table angles per target volume, constrain the number of times the gantry moves along one arc per table angle, i.e. the number of passes, constraint the sum of gantry span per metastasis over all arcs, and constrain the minimum table span. Based on the result of the comparison between the first packed arc setup with the predefined arc setup constraints a second arc setup is automatically suggested. The automatically suggested second arc setup may then be compared with the first one by calculating a score for both setups. Several iterations of such a method can be carried out based on e.g. the comparison between an arc setup and the following, subsequent arc setup in the iteration. If this optimization is converging, which can be controlled by means of e.g. a predefined convergence criterion, this method of automatically finding an optimized arc setup may be stopped and the result may be further used in completely defining the radiotherapy treatment plan.
Patent EP-3863946-A1 (EP)
Inventor: AUSTRHEIM TROND
IPC: B65D88/02
Filed: 2019-09-23
Abstract: The invention relates to a container arrangement comprising a plurality of connected containers, each for storing an automated storage and retrieval system. A coupling arrangement connects and aligns connected containers side-by-side. The containers may be intermodal containers. The invention also relates to a method for providing such an arrangement.
Patent EP-3707415-A1 (EP)
Inventor: Locatelli Andrea
IPC: F16K27/02
Filed: 2019-09-11
Abstract: A check valve (1) for installation on the delivery port (2) of a pump (3) in a pump system, which valve (1) comprises a valve body (4) with an inlet portion (5) and an outlet portion (6) for the fluid (F), which are joined together by a duct (7), a curve (8) coupled to the body (4) and having an inlet end (9) for the fluid (F) that can be connected to the delivery (2) and an outlet end (10) that can be connected to the body (4), a valve member (18) associated with the body (4), wherein the body (4) has an opening (19) that can be closed by a lid (20) and wherein the element (18) is made of a flexible material and is movable between an open position and a position in which the duct (7) is blocked, and comprises a disk-shaped blocking portion (22) designed to sealingly interact with one edge (24) of the curve (8) that projects into the body (4) and a locking portion (25) held in a matingly shaped seat (26) that is only formed in the body (4) and secured therein by the lid (20). The flap disk-shaped blocking portion (22) comprises a core (23) made of a metal material and the locking portion (25) is free of any metal material. The lid (20) is configured to cooperate with the locking portion (25) through a protrusion or a cavity (31) to push the valve member (18) toward the outlet end (10) of the curve (8) to the blocked position and to allow the valve member (18) to deflect toward the interior of the valve body (4) to the open position under the pressure of the working fluid (F) in equilibrium with the weight of the blocking portion (22).
Patent EP-3780624-A1 (EP)
Title: Method for processing image and device therefor
Inventor: NAM JUNGHAK
IPC: H04N19/96
Filed: 2019-04-19
Abstract: Disclosed are a method for decoding a video signal and an apparatus therefor. Specifically, a method for decoding an image may include: partitioning a current coding tree block into a plurality of coding blocks so that coding blocks partitioned from the current coding tree block are included in a current picture when the current coding tree block is out of a boundary of the current picture; parsing a first syntax element indicating whether a current coding block is partitioned into a plurality of subblocks when the current coding block satisfies a predetermined condition; and determining a split mode of the current coding block based on the syntax element.
Patent EP-3761099-A1 (EP)
Inventor: FANG YINLI
IPC: G02B7/02
Filed: 2019-04-26
Abstract: The present application provides an optical lens, comprising: a first lens component comprising at least one first lens sheet; a second lens component comprising a second lens barrel and at least one second lens sheet mounted in the second lens barrel, wherein the at least one second lens sheet and the at least one first lens sheet together constitute an imageable optical system, wherein at least a part of the outer side surface of the second lens sheet at the bottommost end among the at least one second lens sheet is exposed to the outside of the second lens barrel, and the top surface of the second lens sheet at the bottommost end bears against the bottom surface of the second lens barrel; and a connecting medium adapted to fix the first lens component and the second lens component together. The present application further provides a corresponding camera module and optical lens and camera module assembly methods. The present application can effectively reduce the size of the optical lens in the direction perpendicular to the optical axis on the premise of an established optical design, and at the same time can ensure the imaging quality of the optical lens.