Patent SG-11201901097T-A (SG)
Title: Liposomal formulations
Inventor: VENKATRAMAN SUBRAMANIAN
IPC: A61P35/00
Filed: 2017-09-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 March 2018 (22.03.2018) WIP0 I PCT 0111111010 0111 °nolo III m nom INN Hi° oimIE (10) International Publication Number WO 2018/052373 Al (51) International Patent Classification: A61K 9/127 (2006.01) A61P 11/00 (2006.01) A61P 9/00 (2006.01) A61P 1/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/SG2017/050461 (22) International Filing Date: 14 September 2017 (14.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201607641Q 14 September 2016 (14.09.2016) SG (71) Applicants: NANYANG TECHNOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Avenue, Singapore 639798 (SG). SINGAPORE HEALTH SERVICES PTE LTD [SG/SG]; 31 Third Hospital Avenue, #03-03, Bowyer Block C, Singapore 168753 (SG). (72) Inventors: VENKATRAMAN, Subramanian; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). HUANG, Yingying; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). NAGLE, Amrita; c/o Nanyang Technolog- ical University, 50 Nanyang Avenue, Singapore 639798 (SG). NATARAJAN, Jayaganesh V; c/o Nanyang Tech- nological University, 50 Nanyang Avenue, Singapore 639798 (SG). FOIN, Nicolas Daniel Marie; c/o Singapore Health Services Pte Ltd, 31 Third Hospital Avenue, #03-03 Bowyer Block C, Singapore 168753 (SG). CHONG, Tze Tec; c/o Singapore Health Services Pte Ltd, 31 Third Hos- pital Avenue, #03-03 Bowyer Block C, Singapore 168753 (SG). PHUA, Jie Liang; c/o Nanyang Technological Uni- versity, 50 Nanyang Avenue, Singapore 639798 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O Box 1088, Rochor Post Office, Rochor Road, Singapore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: LIPOSOMAL FORMULATIONS FIG. 2b Pharmaceutical agent (e.g siroilmus (57) : According to the present disclosure, a liposomal formulation comprising at least one uncharged phospholipid without cholesterol and at least one pharmaceutical agent, wherein the at least one uncharged phospholipid forms one or more lipid bilayers without cholesterol encapsulating the at least one pharmaceutical agent, is provided. The use(s) of such a liposomal formulation and method of producing such a liposomal formulation are also provided. [Continued on next page] WO 2018/052373 Al MIDEDIMOMOIDEIREEMOTIMIIIIIMMOVOIS OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))