Patent SG-11201906344W-A (SG)
Title: Silicone oil-in-water composition useful as an injectable filler and as a scaffold for collagen growth
Inventor: LORIA VICTOR
IPC: A61K8/89
Filed: 2018-01-12
Abstract: WO 18/ 13 2669 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 July 2018 (19.07.2018) WIPO I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 8/06 (2006.01) A61F 2/10 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 8/89 (2006.01) A61F 2/12 (2006.01) A61K 8/73 (2006.01) A61F 2/26 (2006.01) Published: A61F 2/02 (2006.01) — with international search report (Art. 21(3)) (21) International Application Number: PCT/US2018/013512 (22) International Filing Date: 12 January 2018 (12.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/405,240 12 January 2017 (12.01.2017) US (71) Applicant: LORSTAN PHARMACEUTICAL, LLC [US/US]; 10773 NW 58th Street, Suite 751, Doral, Florida 33178 (US). (72) Inventor: LORIA, Victor; 3625 NW 82nd Avenue, Suite 402, Miami, Florida 33166 (US). (74) Agent: TENER, David M.; Caesar, Rivise PC, 12th Floor, Seven Penn Center, 1635 Market Street, Philadelphia, Penn- sylvania 19103 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: SILICONE OIL-IN-WATER COMPOSITION USEFUL AS AN INJECTABLE FILLER AND AS A SCAFFOLD FOR COLLAGEN GROWTH (57) : The present invention relates to compositions in the form of oil-in-water dispersions comprising a silicone oil having an average droplet diameter of about 2000 microns or less and a polymeric thickening agent. These compositions are useful for stimulating collagen production in human patients and other mammals, and have applications for soft tissue augmentation for various medical and cosmetic procedures. The present invention also relates to methods for preparing these compositions and to methods for stimulating collagen production in human patients and other mammals in need thereof. In contrast to the prior art, the compositions and methods of the present invention are particularly useful for stimulating the production of high quality collagen that is uniform, smooth, long- lasting, and having good structural integrity oimitia °nolo oil! mom Kunio i11110 oimIE (10) International Publication Number WO 2018/132669 Al