Patent SG-11201909606R-A (SG)
Title: Probiotic molecules for reducing pathogen virulence
Inventor: CELLA MONICA ANGELA
IPC: A61K35/745
Filed: 2018-03-16
Abstract: ologicalRep 100.00 90.00 80.00 70.00 60.00 50.00 40.00 30.00 20.00 10.00 0.00 LDH In hi bit ion ( %) *0—Biological Rep 1 0 5 10 15 Concentration of Cell free supernatant (mg/mL) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) REVISED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 1111111111110110101011111011010 I IONN El INOUE 11101111 (10) International Publication Number WO 2018/165765 A9 20 September 2018 (20.09.2018) Wi PO I PCT (51) International Patent Classification: A61K 38/16 (2006.01) A61L 31/16 (2006.01) A23L 33/135 (2016.01) A61P 17/02 (2006.01) A23L 33/195 (2016.01) A61P 31/00 (2006.01) A61K 35/741 (2015.01) CO7K 14/195 (2006.01) A61K 35/744 (2015.01) C07K 14/315 (2006.01) A61K 35/745 (2015.01) C07K 14/335 (2006.01) A61K 35/747 (2015.01) C07K 5/10 (2006.01) A61L 15/44 (2006.01) C07K 7/06 (2006.01) A61L 27/54 (2006.01) Cl 2N 1/20 (2006.01) A61L 29/16 (2006.01) (21) International Application Number: PCT/CA2018/050320 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/472,061 16 March 2017 (16.03.2017) US (71) Applicant: MICROSINTESIS INC. [CA/CA]; 329 Sum- mer Avenue, Oakville, Ontario L6J 1S7 (CA). (72) Inventors: CELLA, Monica Angela; 39 Ducks Landing, Apt. 302, Stratford, Prince Edward Island C1B 2X8 (CA). CURTIS, Sarah M.; 130 Balsam Road, P.O. Box 1065, Atikokan, Ontario POT 1C0 (CA). ROEPKE, Jonathon Patrick; 245 Queen Street, Apt. 3, Charlottetown, Prince Edward Island CIA 4B9 (CA). (74) Agent: LOWTHERS, Erica E. et al.; Aird & McBurney LP, Brookfield Place, 181 Bay Street, Suite 1800, Toronto, Ontario M5J 2T9 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: PROBIOTIC MOLECULES FOR REDUCING PATHOGEN VIRULENCE Figure 1 (57) : Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of non-enteric infections in a subject. Also provided are compositions of the peptides formulated as or within food products, beverages, nutritional supplements, medicaments and the like. O [Continued on next page] WO 2018/165765 A9 IMEDIMOM0101011MENOMMIDEMHINOMEMO# TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (88) Date of publication of the revised international search report: 22 November 2018 (22.11.2018) (15) Information about Correction: see Notice of 22 November 2018 (22.11.2018)