Patent SG-11201806625W-A (SG)
Title: Non-invasive ocular drug delivery insert technology
Inventor: MOTA LEITE MACHADO MARIZ MARCOS JOÃO
IPC: A61K47/34
Filed: 2017-02-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/137934 Al 17 August 2017 (17.08.2017) WIPO I PCT 11111111111111011101111111111101011111011101110111111111111101111111111111111110111111 (51) International Patent Classification: A61K 9/00 (2006.01) 961% 31/192 (2006.01) A61K 47/34 (2017.01) A61K 31/4709 (2006.01) (21) International Application Number: PCT/IB2017/050731 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 109154 12 February 2016 (12.02.2016) PT (71) Applicant: UNIVERSIDADE DE COIMBRA [PT/PT]; Paco das Escolas, 3004-351 Coimbra (PT). (72) Inventors: MOTA LEITE MACHADO MARIZ, Mar- cos Joao; Rua Antonio Goncalves, if 95 R/C A Qta da Varzea, Santa Clara, 3040-241 Coimbra (PT). NUNES FERREIRA CALVINHO, Paula Cristina; Urbanizacao Nova Conimbriga, n° 16, Condeixa-a-Velha, 3150-230 Condeixa-a-Nova (PT). MENDES GIL, Maria Helena; Rua Dias da Silva, n° 108 R/C Dto, 3000-135 Coimbra (PT). NETO MURTA, Joaquim Carlos; Rua Dias da Silva, n° 88, 3000-135 Coimbra (PT). (74) Agent: PEREIRA DA CRUZ, Joao; J. Pereira Da Cruz, S.a., Rua Vitor Cordon, 14, 1249-103 Lisboa (PT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) W O 20 17 / 137 93 4 Al (54) Title: NON-INVASIVE OCULAR DRUG DELIVERY INSERT TECHNOLOGY (57) : Non-invasive Ocular Drug Delivery Insert Technology The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a \"Fickian\" or a linear profile according to the intend purpose or pathology. The insert can be prepared with different shapes (spherical or spherical dome) and/or architectures (monolithic/layered either with or without a drug core) allowing the incorporation of at least one drug which can be re- leased at different rates. The size, shape and design of the insert is adjusted in order to tune the drug(s) delivery profile(s) and to in- hibit the risk of displacement or expulsion.