baber/WOPTO huggingface dataset:
Patent EC-SP056114-A (EC)
Title: Combinaciones antineoplásicas
Inventor: SHERMAN MATTHEW L
IPC: A61K31/44
Filed: 2005-10-21
Abstract: Esta invención provee el uso de una combinación de CCI-779 e interferón (a) en el tratamiento de neoplasias.
Patent EC-SP066437-A (EC)
Title: Combinación de un inhibidor de receptor de vegf con un agente quimioterapéutico
Inventor: MANLEY PAUL WILLIAM
IPC: A61K31/502
Filed: 2006-03-17
Abstract: La presente invención se refiere a una terapia de combinación para el tratamiento de pacientes que sufran de enfermedades proliferativas o enfermedades asociadas con angiogénesis persistente. El paciente se trata con: (a) un compuesto inhibidor de VEGF; y (b) uno o más agentes quimioterapéuticos seleccionados a partir del grupo que consiste en: i. un inhibidor de aromatasa; ii. un anti-estrógeno, un anti-andrógeno (en especial en el caso de cáncer de próstata), o un agonista de gonadorelina; iii. un inhibidor de topoisomerasa I ó un inhibidor de topoisomerasa II; iv. un agente activo en microtúbulos, un agente alquilante, un anti-metabolito anti-neoplástico, o un compuesto de platina; v. un compuesto que dirige/reduce una actividad de quinasa de proteína o de lípido o una actividad de fosfatasa de proteína o lípido, un compuesto anti-angiogénico adicional, o un compuesto que induzca procesos de diferenciación celular; vi. un receptor de bradiquinina 1 ó un antagonista de angiotensina II; vii. un inhibidor de ciclo-oxigenasa, un bisfosfonato, un inhibidor de heparanasa (que previene la degradación del sulfato de heparano), por ejemplo PI-88, un modificador de la respuesta biológica, de preferencia una linfocina o interferones, por ejemplo interferón ?, un inhibidor de ubiquitinación, o un inhibidor que bloquee las sendas anti-apoptóticas; viii. un inhibidor de las isoformas oncogénicas Ras ó un inhibidor de farnesil-transferasa; ix. un inhibidor de telomerasa, por ejemplo telomestatina; x. un inhibidor de proteasa, un inhibidor de metaloproteinasa de matriz, un inhibidor de aminopeptidasa de metionina, por ejemplo bengamida o un derivado de la misma, o un inhibidor de proteasoma, por ejemplo PS-341; xi. agentes utilizados en el tratamiento de malignidades hematológicas o inhibidores de quinasa de tirosina tipo FMS; xii. inhibidores de HSP90; xiii. inhibidores de HDAC; xiv. inhibidores de mTOR; xv. antagonistas del receptor de somatostatina; xvi. antagonistas de integrina; xvii. compuestos anti-leucémicos; xviii. planteamientos que dañan las células tumorales tales como radiación ionizante; xix. enlazadores de EDG; xx. la clase de inhibidores de quinasa de amida del ácido antranílico; xxi. inhibidores de reductasa de ribonucleótido; xxii. inhibidores de descarboxilasa de S-adenosil-metionina; xxiii. anticuerpos contra VEGF ó VEGFR; xxiv. terapia fotodinámica; xxv. esteroides angiostáticos; xxvi. implantes que contienen corticosteroides; xxvii. antagonistas del receptor AT1; y xxviii. inhibidores de ACE.
Patent EC-SP078010-A (EC)
Title: Formulación de liberación prolongada de principios activos que presentan una solubilidad dependiente del ph
Inventor: ALAUX GERARD
IPC: A61K9/24
Filed: 2007-12-13
Abstract: La invención se refiere a una formulación nueva para una liberación prolongada de un principio activo que presenta una solubilidad dependiente del pH. La formulación de la invención comprende un excipiente matricial a base de polímero hidrófilo que contiene una dosis determinada del principio activo, y también comprende uno o varios agentes acidificantes en forma de una sal ácida de un ácido orgánico.
Patent EC-SP972234-A (EC)
Title: Sistema continuo de laminacion en caliente de perfiles livianos de acero de bajo consumo de energia y baja inversion
Inventor: YANDUN CARDENAS HENRY JAVIER
IPC: B21C9/00
Filed: 1997-08-22
Abstract: Sistema de laminación de perfiles livianos de acero, que se realiza en caliente, partiendo de alambrón como materia prima, el cual permite realizar la mayor variedad de perfiles livianos, con mínimas inversiones y considerables ahorros de energía y mano de obra, en comparación con los sistemas de uso.
Patent EC-SP982719-A (EC)
Title: Un embalaje para productos; tales como productos alimenticios
Inventor: MILANO GIUSEPPE
IPC: B65D75/32
Filed: 1998-10-30
Abstract: El embalaje (1) comprende dos semi-carcasa (2,3) generalmente huecas, unidas cada una con la otra según una relación cara-con-cara a lo largo de sus bordes (2¿, 3¿) de embocadura asociados. Al menos una, y con preferencia ambas semi-carcasa (2,3) mencionadas, están cerradas por medio de láminas (6,1) asociadas de sellado, cuya unión en las superficies enfrentadas conduce a la unión de las dos semicarcasas (2,3); ambas semi-carcasas (2,3) asi como también la lámina o láminas (6,7) se ha sellado, se han dotado de proyecciones (20, 30, 60, 70) para su uso en la apertura del embalaje, formadas en correspondencia con los bordes (2¿3¿¿) de embocadura de las semi-carcasas (2,3 = de modo que se alinean y se superponen cada una con respecto a la otra en el embalaje acabado. La unión de la lámina o las láminas (6, 7) de sellado con la semicarcasa (2, 30) asociada, incluye también las partes de lengueta mencionadas anteriormente, las cuales no están afectadas, sin embargo, por la unión de las dos semi-carcasa (2, 3) entre si. Por consiguiente, la semi carcasas (2,3) entre si. Por consiguiente, las semi-carcasas (2, 3) pueden ser separadas una de la otra sin riesgo de separación indeseada de la lámina o láminas (6, 7) de sellado de las semicarcasas, cuyas láminas están previstas para ser retiradas posteriormente con el fin de acceder al contenido de las semi-carcasas (2, 3). La unión entre las diversas partes se consigue, con preferencia, por medio de sellado ultrasónico.
Patent EG-24223-A (EG)
Title: Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiopehene and salts thereof
Inventor: FADIA BASHORE N
IPC: A61K9/00
Filed: 2001-05-05
Granted: 2008-11-10
Abstract: The present invention is directed to pharmaceutical formulations containing 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene or a salt thereof; stabilized to oxidation or other forms of decomposition by incorporation of a stabilizing agent selected from methionine, acetylcysteine, cysteine or salts thereof.
Patent FI-20010313-A (FI)
Inventor: MARTIKAINEN ILPO
IPC: H04R1/28
Filed: 2001-02-19
Abstract: The loudspeaker construction comprises a loudspeaker chamber delimited by a loudspeaker enclosure structure, a reflex duct communicating with the loudspeaker chamber so as to connect the loudspeaker chamber to the exterior environment of the loudspeaker enclosure, and at least one loudspeaker unit mounted on the loudspeaker enclosure structure so as to form a portion of the delimiting walls of the loudspeaker chamber. According to the invention, the loudspeaker enclosure structure comprises a curved spiral structure closed from its both sides by gable elements so as to form the loudspeaker chamber, and the reflex duct is adapted at least partially running on the outer periphery of the spiral structure.
Patent FI-20050827-A (FI)
Inventor: AALTO VEIJO
IPC: F21V/
Filed: 2005-08-16
Abstract: The invention relates to a light-permeable protection (1) for a ceiling lamp. The lighting fixture (2) comprises a reflector (3) and, as fitted therein, a replaceable electric light source (4), such as a mercury lamp, so that said protection is fastened in connection with the reflector of said lighting fixture. According to the invention, the protection (1) is realized to be a separate accessory including a light-permeable cupola part (11) and a collar (12) provided with fastening means (13), such as a number of screws or a hoop and latch arrangement, for fastening the cupola part detachably to the reflector of the lighting fixture, so that it encompasses the light aperture (31) of the reflector (3). The invention also relates to a lighting fixture (2) provided with a protection (1).
Patent FR-1602525-A (FR)
Title: Heat exchanger for two liquids
IPC: F28F21/06
Filed: 1968-09-19
Granted: 1970-12-21
Abstract: An external watertight compartment houses an elastically deformable plastic envelope contg. a series of thermosoldered, corrugated vertical elements constructed to form a continuous channel through the envelope in the form of linked U-shaped sections. The primary exchange fluid is fed to the inner envelope which inflates to a volume governed by the pressure and flow of secondary fluid through the volume defined by the external and internal compartment walls. The thermal efficiency may readily be controlled to give a high conductivity across the thin plastic walls.
Patent GB-1051824-A (GB)
IPC: B01J31/04
Abstract: 1,051,824. Halogenation catalyst. SOC. D'ELECTRO-CHIMIE. D' E L E C T R OMETALLURGIE ET DES ACIERES ELECTRIQUES D'UGINE. July 19, 1965 [July 28, 1964], No. 30624/65. Heading B1E. [Also in Division C2] Cadmium salts, e.g. acetate, nitrate, sulphate are supported on a porous support e.g. C including active carbon, Al 2 O 3 , ZrO 2  or ThO 2 .
Patent GB-1052440-A (GB)
IPC: C08G75/06
Abstract: 1,052,440. Polythioacetal from trithiane. ASAHI KASEI KOGYO KABUSHIKI KAISHA. July 8, 1964 [July 8, 1963; Sept. 13, 1963], No. 28200/64. Heading C3P. Polythioacetal is produced by polymerizing trithiane using a polymerization catalyst of general formula where X is OH, SH, OR 2 , SR, OOCH, OOCR 2 , O 3 SR 2  or halogen, R 1  and R 2  being the same or different and each being an alkyl, cycloalkyl, aryl, aralkyl or alkaryl group which group may carry functional groups comprising one or more of hydrogen, halogen, nitrogen, oxygen or sulphur and in which R 2  and X may form a ring together with the S atom in the general formula or R 2  is a metaloxy group when it is a O 3 SR 2  group. Amongst the catalyst specified are metal hydrosulphates, metal pyrosulphates, metal alkyl sulphates, metal aralkylsulphates, toluene sulphonic acid, the methylester of paratoluene sulphonic acid, benzene sulphonic Anhydride, orthosulpho-benzoic anhydride, and alkali metal lauryl sulphate. The polymerization may take place in the solid state below the melting point or in the molten state or with the trithiane in the completely or partially dissolved state in a hydrocarbon solvent, e.g. diphenyl, or with the trithiane crystals in suspension or molten trithiano disposed in an aliphatic hydrocarbon non-solvent such as paraffin wax.
Patent GB-1052542-A (GB)
IPC: F16B39/34
Abstract: 1,052,542. Electron beam apparatus. COMPAGNIE D'APPLICATIONS MECANIQUES A L'ELECTRONIQUE, AU CINEMA ET A L'ATOMISTIQUE (C.A.M.E.C.A.). Jan. 19, 1965 [Jan. 21, 1964], No. 2387/65. Heading H1D. In an electron beam microanalyser the specimen chamber 2 is supported on a plate 8 which is pivotally mounted at 9 on a slider (not shown) which is free to move within a sleeve 23. The sleeve 23 at the end of a bracket 5 which can slide on a post 6 and can also swing about it. The system can thus be swung from the position shown in which the system rests on a truncated boss 16 to a position out of the plane of the paper in which plane the system can be allowed to drop slightly so as to be supported by the bracket 5 on the base-plate 7. The specimen can then be changed. After changing the specimen the system can be swung back and moved upwardly on to the boss 16 to the position shown. By moving the system upwards the top of the specimen chamber 2 is brought into sealing contact with the main body 3 of the analyzer. To move the chamber upwards a pin 13 fixed to the slider within the bracket 23 is acted upon by the cammed surface 22 of a rotatable sleeve 14. A further bracket (not shown) mounted on a pivot on the base-plate 7 has a finger engaging the plate 8 to ensure that the chamber is kept in the same plane while it is pivoted. Locating studs for the chamber on the plate 8 and for the chamber relative to the analyzer body 3 are also provided.
Patent GB-1054928-A (GB)
IPC: H01J61/073
Abstract: 1,054,928. Metal-vapour lamps. ASSOCIATED ELECTRICAL INDUSTRIES Ltd. Nov. 11, 1963 [Dec. 3, 1962], No. 45638/62. Heading H1D. A high pressure mercury vapour lamp includes electrodes, and supports therefore, of tungsten and/or carbon, and a filling which includes, in addition to mercury, the halide of a metal of low thermionic work function, preferably caesium iodide, for activating the electrodes, any additional metals present being also in the form of halides. Fillings referred to are composed of mercury, a rare gas, a halide of caesium, barium, strontium, calcium, or thorium, for actuating the electrodes, and a halide of sodium, lithium, indium, or thallium for modifying the spectrum of the emitted light, the total pressure being not less than 200 torr in operation. The lamp, which may have a ceramic envelope, may be enclosed in a glass outer jacket, and have a loading of 10 watts cm.<SP>-2</SP>.
Patent GB-1227325-A (GB)
IPC: F41A9/83
Filed: 1969-02-20
Abstract: 1,227,325. Ammunition magazine; baseless ammunition. DYNAMIT NOBEL A.G. 20 Feb., 1969 [21 Feb., 1968], No. 9348/69. Headings F3A and F3C. A magazine comprises strip material 1 provided with a plurality of spaced apertures or recesses each aperture or recess accommocating an unencased propellant charge 3, the strip being of substantially uniform cross-section along its length except for the apertures or recesses. A layer 5 of film material may be releasably bonded to the surfaces of the strip material, the film material being removed from the strip material on to rollers prior to the magazine being fed into a firearm (Fig. 5, not shown). Projectiles 8 which may be bullets (as shown) for military purposes or bolts or nails for industrial purposes may be connected directly to the propellant charges or separated therefrom by a web passing across the recesses (Fig. 7, not shown). The charges may be the same (Fig. 1, not shown) cross-sectional shapes as the recesses or different (Fig. 2, not shown) therefrom, the charges being held in the recesses by frictional forces. A plurality of projections and/or openings may be provided on the edge regions of the face or faces of the strip on to which the apertures or recesses open to facilitate feeding of the magazine.
Patent GB-1228065-A (GB)
IPC: B01J39/16
Filed: 1969-03-31
Abstract: 1,228,065. Agarose derivatives. INSTITUTUL DE BIOCHIMIE AL ACADEMIEI RSR. 31 March, 1969 [30 March, 1968], No. 16698/69. Heading C3U. Novel sulphoethyl derivatives of agarose, or of agarose cross-linked with glyceric bridges, are prepared by treating the agarose or crosslinked agarose, in alkaline medium, with sodium bromoethylsulphonate and heating in a nitrogen atmosphere at 115-120‹ C.
Patent GB-1228791-A (GB)
IPC: B60V3/04
Filed: 1967-05-01
Abstract: 1,228,791. Gas cushion vehicles; tracks. HOVERCRAFT DEVELOPMENT Ltd. 19 April, 1968 [1 May, 1967], No. 20065/67. Headings B7K and B7L. A track 1 in combination with a gas cushion vehicle 3, Fig. 1, is formed in one piece of concrete of generally T-shaped lateral cross-section, whereby the distance D between the vertical side portions 4, which co-operate with the lateral guidance cushions 6 of the vehicle, is substantially less than the width W of the horizontal upper portion 2, which co-operates with the supporting gas cushions 6 of the vehicle, the cushion 6 being formed by units 5 as disclosed in Specification 1,165,732. The track 1 is supported above ground level by reinforced concrete pylons 1a. As shown in Fig. 2 the vehicle is driven by a linear electric induction motor comprised of pole units 12 on the vehicle which coact with a rail 10 resiliently secured at 11 to the bottom of the portion 2, the motor being supplied with current from conductors 24 on the track and pick-up means 23 on the vehicle. A brake pad 21, a roller, or an air cushion, is provided on the vehicle 3 to engage the bottom of the portion 2 to restrict aerodynamic lift. The vehicle cushion units 5 are supplied with air under pressure from a compressor 8, driven by a variable speed engine 9, via pipes 7. The upper surface of the track portion 2 may be convex and the side walls 4 may slope downwardly and inwardly towards each other.
Patent GB-1230078-A (GB)
IPC: F16B21/18
Filed: 1967-06-22
Abstract: 1,230,078. Circlips. PAGE ENG. CO. (SUNBURY-ON-THAMES) Ltd. 16 Aug., 1968 [22 June, 1967], No. 28819/67. Heading F2H. A circlip 10 comprises a resilient split ring having lugs 13 and axial undulations to enable it to be resiliently compressed between flat annular surfaces engaging its opposite faces. The circlip may be provided with openings for engagement by a tool and/or with upturned, inturned or out-turned lugs. Also the number and direction of projection of the undulations may vary.
Patent GB-1230084-A (GB)
IPC: D04B15/32
Filed: 1967-05-06
Abstract: 1,230,084. Knitting-machines. BENTLEY MACHINE DEVELOPMENT CO. Ltd. 30 April, 1968 [6 May, 1967], No. 21188/67. Heading D1C. The stitch cam 34, upthrow cam or sinker cam of a circular machine has a concave surface 36a preceded by a surface 36 of decreased angle of lead-in such that high speed knitting is attained by the butts of the instruments engaging the surface 36 and the instruments being progressively increased in their movement as the butts move along the surface. The bottom or innermost edge 37 of the cams is rounded to reduce the sudden projection of the butts and instruments off the end of the cam surface. The landing cam 35 is also correspondingly caused to receive the butts as they are projected from the cam surface. In a two feeder machine selection is made by passing or mispassing selector jacks which are raised or missed by a cam having a surface of similar configuration to that described above. Tuck work is produced by suitable selection. A retaining cam between feeds retains the inoperative selectors within the tucks between feeds.
Patent GB-1231525-A (GB)
IPC: A01K63/04
Filed: 1969-11-11
Abstract: 1,231,525. Filters for aquaria. STERNCO INDUSTRIES Inc. 11 Nov., 1969 [21 April, 1969], No. 55080/69. Heading B1D. The filter medium 47 required for immersion below the water in an aquarium tank is contained in a casing 13 having, in the rear wall 18, an aperture 29 which is fitted onto the tab 30 of a bracket 9 which is supported on the upper rim at the top of the glass panel 35 of the tank. Air is pumped through flexible tube 44 into the top of the casing 13 whereby water is drawn into it through slots in the sides and the floor, the filtered water being returned to the tank, together with air, through pipe 28 which is, optionally, connected to carbon cartridge 46. When the filter medium 47 is contaminated, the bracket is lifted out of the tank, the casing is detached from the bracket and the tube 44, and replaced by a new casing with fresh filter medium. Filter floss, i.e. a loose mass of fibres, may be used as filter medium.
Patent GB-1232006-A (GB)
IPC: B21B31/08
Filed: 1967-07-22
Abstract: 1,232,006. Rolling. DAVY & UNITED ENG. CO. Ltd. 19 July, 1968 [22 July, 1967], No. 33818/67. Heading B3M. The work rolls 12 and 13 (Fig. 1) of a mill are, together with their chocks 15 and 16, removable as a unit from the mill, using vertical rods 17 and 18 which pass through bores in the chocks. Each rod is fixed in an upper chock 15 by a cotter 23 and by an enlarged collar, but is freely slidable in a lower chock 16. When the rolls are to be removed, the upper roll assembly is lifted from the lower assembly until bolts 26 can be slid beneath the rods. The roll necks are then at a desired spacing and can be engaged by a counterbalanced porter bar 32 (Fig. 3) to permit removal of the assemblies. The bolts are operated by solenoid-controlled piston and cylinder assemblies (Fig. 2, not shown).
Patent GB-1232573-A (GB)
IPC: E06B7/23
Filed: 1967-03-29
Abstract: 1,232,573. Draught excluders. J. SADLER, M. S. SADLER and H. SADLER [trading as BENTON JOINERY CO.]. 24 May, 1968 [29 March, 1967], No. 14395/67. Heading E1J. A timbered window or door 4, hinged at 10 is sealed against draughts by a resilient (P.V.C.) seal strip 8 mounted in a peripheral groove 6 in the fixed frame 2 and of undercut section to receive a root portion of the strip 8 of wider cross-section than the minimum width of the groove so as to engage at least part of the side walls of the groove and be retained in the groove by its own resilience with a riblike portion projecting from the groove to contact, in the closed position of the door 4 the closing face of the hinged frame of the door, the strip lying wholly within the projected area of that face of the hinged frame as by the grooves being formed directly in the timber of the fixed frame, or in narrow faces of rectangular battens secured to the sides, top and bottom of the fixed frame, so that the strips are abutted by the closing face of the frame 4 when closed. The strip may have a section as shown in Fig. 3.
Patent GB-1233488-A (GB)
IPC: B01J39/04
Filed: 1969-10-08
Abstract: 1,233,488. Ion-exchange. ECONOMICS LABORATORY Inc. 8 Oct., 1969 [18 Oct., 1968], No. 49421/69. Heading B1J. [Also in Division A4] A dishwashing system comprises in combination a dishwashing machine and water treatment means including a weakly acidic cation exchange resin in the hydrogen form and means for passing water which may be hot, from the water treatment means to at least one stage in the cycle of operations of the machine. Weakly acidic cation exchange resins are considered to have a pKa value greater than 4.0 and are exemplified by polyacrylic acid crosslinked with divinylbenzene (pka=5.3).
Patent GB-1233561-A (GB)
IPC: C11B1/10
Filed: 1968-03-07
Abstract: 1,233,561. Extracting. ROSE, DOWNS & THOMPSON Ltd. 5 July, 1968 [7 March, 1968], No. 11132/68. Heading B1Q. In an extraction apparatus of the type in which material is fed to a series of cells arranged around a vertical axis and in which the material is discharged from a door at the bottom, e.g. 644910, each cell is separated from an adjacent cell by a single thickness side wall disposed between radial inner and outer walls with horizontal separation greater at the bottom and the door is hinged to the outer or inner wall or both.
Patent GB-1239026-A (GB)
IPC: B29C65/06
Filed: 1968-08-05
Abstract: 1,239,026. Welding by pressure. NATIONAL RESEARCH INSTITUTE FOR METALS, DIRECTOR OF. 5 Aug., 1968 [5 Aug., 1967], No. 37177/68. Heading B3R. In friction welding two members, one is positively driven in rotation and the members are pressed together axially to generate a frictional force between them with the development of heat at the area of contact, the other member being accelerated under the frictional force and sufficient heat being developed by the time the other member has reached the speed of the driven member to weld the members together. Member 1 is attached to a shaft journalled in a bearing support 13 and driven by drive means 17 and member 2 is attached to a freely rotatable shaft journalled in bearing supports 14 and 15, the freely rotatable shaft carrying a flywheel 5 and being axially movable by a pressure device 16. In operation the member 1 is rotated by the means 17 to a constant speed, the member 2 is pressed against the member 1 by the means 16 to accelerate it until its speed equals that of member 1. During the relative rotation of the members frictional heating occurs and welding is completed by the time the relative rotation has ceased. The moment of inertia of the wheel 5 may be adjusted to provide different energy requirements. When the members 1, 2 are tubular the flash generated within the tubes is removed by an internal cutter during welding or both inner and outer flash may be removed simultaneously. The member 2 may be kept stationary during the initial period of contact until flash begins to form. Carbon steel may be welded to carbon steel or stainless steel, stainless steel to stainless steel, high-speed steel to highspeed steel and chromium-molybdenum steel to chromium-molybdenum steel.