baber/WOPTO huggingface dataset:
Patent EA-001779-B1 (EA)
Title: Thrapeutic treatment for vegf related diseases
Inventor: JIROUSEK MICHAEL R
IPC: A61K31/706
Filed: 1997-05-01
Abstract: 1. A method for treating a neoplasia which comprises administering to a mammal in need of such treatment, a therapeutically effective amount of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt. 2. The method of claim 1 wherein the neoplasia is selected from the group consisting of capillary hemangioblastomia, breast cancer, Kaposi's sarcoma, glioblastoma, angiomatous disorders, hemangioma of infancy, colorectal cancer, medulloblastoma, gastric carcinoma adenocarcinomas of the gastrointerestinal tract, malignant melanoma, ovarian cancer, non small cell lung cancer, prostate cancer, malignant effusion, preitumoral edema, bladder carcinoma, von Hippel Lindau Syndrome, renal cell carcinoma, skin cancer, thyroid malignancies, cervical canc er, hepatocellular carcinoma, rhabdomyosarcoma, and leiomysarcoma. 3. The method of claim 10 wherein the neoplasia is selected from the group consisting of capillary hemangioblastomia, breast cancer, Kaposi's sarcoma , glioblastoma, angiomatous disorders, hemangioma of infancy, colorectal cancer, malignant melanoma, ovarian cancer, non small cell lung cancer, prostate cancer, malignant effusions, preitumoral edema, bladder carcinoma. 4. A method for treating rheumatiod arthritis, which comprises administering to a mammal in need of such treatment, a therapeutically effective amount of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt. 5. A method for treating pulmonary edema, which comprises administering to a mammal in need of such treatment, a therapeutically effective amount of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt. 6. A method for inhibiting VEGF stimulated capillary permeability associated with pulmonary edema, which comprises administering to a mammal in need of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt. 7. A method for treating keloid, which comprises administering to a mammal in need of such treatment, a therapeutically effective amount of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt. 8. A method for treating Carpal tunnel syndrome, which comprises administering to a mammal in need of such treatment, a therapeutically effective amount of (S)-3,4-[N, N'-1,1'-((2"-ethoxy)-3"'(O)4"'-(N,N-dimethylamino)-butane) -bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or its pharmaceutically acceptable ac id salt.
Patent EA-000854-B1 (EA)
Title: A method of the generation of a tension for detecting an ion current
Inventor: BENGTSSON JORGEN
IPC: F02D45/00
Filed: 1997-06-11
Abstract: 1. A method for the generation of a voltage for detecting an ionization current in a spark gap of an internal combustion engine, characterized in that a controllable ignition magneto (5) or the like is arranged on the primary side of the ignition device in order to charge an ignition capacitor (4), and that after the ignition of a spark and after the decay of the spark said ignition magneto is connected to a special primary winding (B) on the primaryside, as a low tension source (3), so as to generate an ion measuring tension, after which the ion current is detected (11) on the low tension side of the secondary side of the ignition device. 2. A method according to claim 1, characterized in that the amplitude of the ion current/ion voltage is controllable 3. A method according to any of claims 1-2, characterized in that the duration of the ion current is controllable. 4. A method according to any of claims 1-3, characterized in that the time for the connection of the ion current is controllable so as to eliminate measurement disturbances originating from said spark and said decay of the spark. 5. A method according to any of claims 1-4, characterized in that the ion measuring tension is maintained on a DC level by means of the distributed capacities in the ignition coils of the ignition device. 6. A method according to any of claims 1-5, characterized in that special distributed capacities are created to be used for the generation of the ion measuring tension.
Patent EA-002483-B1 (EA)
Title: Method for the separation of acid from sugars
Inventor: RUSSO LAWRENCE J JR
IPC: B01D15/18
Filed: 1998-08-03
Abstract: 1. A method for separating acid and sugars obtained from liquids resulting from the acid hydrolysis of a material containing at least one of cellulose and hemicellulose, comprising adding the liquids to a separation unit comprising a bed of anionic exchange or exclusion chromatographic material whereby the acid is adsorbed onto the chromatographic material, thereby producing a series of first fractions comprising sugar solutions and a later series of fractions comprising acid solutions. 2. The method of claim 1, wherein said sugar solutions are contaminated by acid and heavy metals. 3. The method of claim 2, wherein further comprising removing the residual acid and heavy metals from the combined sugar solution by treatment with lime, thereby neutralizing the acid and precipitating the heavy metals to give gypsum containing the heavy metals. 4. The method of claim 3, wherein combining the sugar solutions prior to removing the residual acid and heavy metals. 5. The method of claim 1, wherein said acid is sulfuric acid. 6. The method of claim 1, wherein said chromatographic material is an ion-exclusion resin. 7. The method of claim 1, wherein said at least one of cellulosic and hemicellulosic materials are derived from MSW. 8. The method of claim 1, , wherein said at least one of cellulosic and hemicellulosic materials are derived from sewage sludge or septage or waste water sludges or commercial waste streams. 9. The method of claim 1, wherein prior to adding the liquids to a separation unit, the liquids, obtained from the acid hydrolysis are diluted with water and heated for a time sufficient to hydrolyze substantially the at least one of cellulose and hemicellulose. 10. The method of claim 1, wherein the sugar solutions obtained from the separation unit are combined and recycled to the separation unit. 11. The method of claim 9, wherein the water is waste water or sewage containing organic nitrogen. 12. The method of claim 10, wherein the sugar containing solution after treatment with lime is concentrated to about 12-22% sugar. 13. The method of claim 1, wherein combining and concentrating the fractions comprising acid and recycling in the separation unit at least once. 14. The method of claim 1, wherein the liquids comprising acid and sugars are separated by a continuous ion exchange or exclusion chromatography using a simulated moving bed apparatus containing an anionic exchange or exclusion chromatographic material. 15. The method of claim 12, wherein further comprising fermenting with yeast the obtained solution to give a beer, optionally removing the yeast from the obtained beer and distilling the ethanol from the beer.
Patent EA-003011-B1 (EA)
Title: Device for removing deposit created in electrolytic refining or electrowinning
Inventor: MARTTILA TOM
IPC: C25C7/08
Filed: 2000-05-19
Abstract: 1. A device for at least partly removing a deposit created in electrolytic refining or electrowinning from the surface of the mother plate used as an electrode in the refining or electrowinning process, said device comprising at least one member for removing the deposit and at least one member for controlling the removal member with respect to the deposit, characterised in that the device comprises at least one gripping element (4) that is used for creating a mechanical contact between the deposit (1) and the removal member, said gripping element (4) being connected to a control member (5), to which there are coupled both the shaft part (6) of the gripping element and the deposit removal member (9). 2. A device according to claim 1, characterised in that the gripping element (4) is installed so that it is movable in a direction essentially parallel to the surface of the mother plate (2) and in a direction essentially perpendicular to the surface of the mother plate (2). 3. A device according to claim 1 or 2, characterised in that in order to move the gripping element (4) in a direction essentially parallel to the surface of the mother plate (2), the shaft part (6) of the gripping element (4) is provided with a drive member (8). 4. A device according to any of the preceding claims, characterised in that the moving of the gripping element (4) in a direction essentially perpendicular to the surface of the mother plate (2) can be carried out by means of a removal member (9) of the deposit (1). 5. A device according to any of the preceding claims, characterised in that the shaft part (6) of the gripping element is rotated around its axis. 6. A device according to any of the preceding claims, characterised in that the moving of the gripping element (4) both in a direction essentially parallel to the surface of the mother plate (2) and in a direction essentially perpendicular to the surface of the mother plate (2) can be carried out hydraulically. 7. A device according to any of the preceding claims 1-5, characterised in that the moving of the gripping element (4) both in a direction essentially parallel to the surface of the mother plate (2) and in a direction essentially perpendicular to the surface of the mother plate (2) can be carried out pneumatically. 8. A device according to any of the preceding claims 1-5, characterised in that the moving of the gripping element (4) both in a direction essentially parallel to the surface of the mother plate (2) and in a direction essentially perpendicular to the surface of the mother plate (2) can be carried out electrically. 9. A device according to any of the preceding claims, characterised in that in order to remove the deposit (1), the control member (5) of the gripping element is in contact with that part of the mother plate (2) that is clear of the deposit (1), simultaneously as the gripping element (4) is in contact with the deposit (1) to be removed.
Patent EA-008677-B1 (EA)
Title: Method for generating pseudo-random sequence
Inventor: VAUDENAY SERGE
IPC: H04L9/22
Filed: 2004-09-02
Abstract: The aim of this invention is to propose a method to generate sequences or sub-keys based on a main key, in which each sub-key gives no information to recover the main key or any other sub-keys. The aim is achieved with a method to generate sub-keys based on a main key (MKEY), comprising the following steps: - obtaining a first value (A1) by applying to the main key (MKEY) a linear diversification layer by mixing the main key (MKEY) with a constant, - applying to the first value (A1) a non-linear transformation, this transformation comprising the steps of: - obtaining a second value (A2) by applying the first value (A1) to a substitution layer, the substitution layer comprising at least one substitution box (sbox), each substitution box containing at least one table of constants for which the input serves as the pointer and the pointed constant serves as the output, - obtaining a third value (A3) by using a diffusion box of multi-permutation type based on the second value (A2), - dividing the third value (A3) in N blocks of same size, obtaining the output fourth value (A4) formed by N blocks, each block of the fourth value (A4) being the result of the combination of N-1 blocks of the third value (A3), the missing block being the block of the same index, - obtaining the fifth value (A5) by applying to the fourth value (A4) a substitution layer, - obtaining the sub-key (RKEY) by applying to the fifth value (A5) a symmetrical encryption module, the first value (A1) serving as the key input for this module.
Patent EA-008486-B1 (EA)
Title: Laminated element for fixing panel parquet
Inventor: SHATROV ALEXANDR AVDEEVICH
IPC: E04F15/02
Filed: 2006-03-06
Abstract: The invention relates to parquet fabrication and, in particular, to a method of fixing parquet boards or panel parquets therebetween.A laminated element of panel parquet fixing is placed in their longitudinal side edges and has a cross-shaped configuration (1), each radial plate of which is interposed in response longitudinal interstices (3) of adjacent edges of panel parquet (2).The laminated element is made of a sheet material and symmetric in shape, wherein the length of each radial plate constitutes at least 0.15 of the length of the panel adjacent edge.Depending upon the use of panel parquet the laminated element can be made of different materials: ferrous metal, e.g. steel, a non-ferrous metal, e.g. aluminum alloy, a thermoplastic, a thermoset plastic, composite materials, e.g. glass or coal-plastic.A laminated element being shaped as a cross and fixing parcel parquet provides quality flooring, simplifies laying of panel parquet and better parquet levelling.
Patent EA-010341-B1 (EA)
Title: Digging and pulling unit assembly and harvesting machine comprising such a unit assembly
Inventor: STOECKL HUBERT
IPC: A01D27/04
Filed: 2006-10-06
Abstract: In a digging-pulling unit for a harvesting machine, in particular for self-propelled machine or a combine harvester for uprooting root crops, in particular sugar beet with a leaf stripper unit and the digging-pulling init comprising digging elements, as well as a sensing arrangement with at least one sensing wheel which is supported on soil during uprooting and controls uprooting depth. The sensing wheel arrangement is arranged between the leaf stripper unit and the grubbing-pulling unit and controls the altitude of the leaf stripper unit with respect to the level of the soil.
Patent EA-009244-B1 (EA)
Title: Method of improving the efficiency of fat separation in the separation of a liquid food product
Inventor: DUCHESNE MARIUS
IPC: A01J11/10
Filed: 2005-03-14
Abstract: The disclosure relates to a method of improving the efficiency of fat separation in the separation of a liquid food product with a certain fat content. The method comprises the method step that the liquid food product is caused to pass through a first separator (1) where the product is divided up into a lighter and a heavier phase. The first separator (1) is regulated so that the lighter phase will have a fat content which is less than 15%. The method also includes the method step that the lighter phase is caused to pass through a second separator (7).
Patent EA-012253-B1 (EA)
Title: Localized media content management
Inventor: ROYO JOSE A
IPC: G06F7/00
Filed: 2006-08-31
Abstract: An embodiment of the present invention is a technique to localize content management of media content assets. A local content is received at a regional media center. The local content corresponds to an event localized within a locality. The local content is prepared into an asset using a media content management system. An asset package containing the asset is propagated to a head-end for distribution to a subscriber in the locality. In another embodiment of the invention, an asset package containing an asset and asset attributes is received from a propagation unit. The asset is created from a local content corresponding to an event localized within a locality. The asset is distributed to a subscriber in the locality.
Patent EA-018645-B1 (EA)
Title: Flush valve
Inventor: VAREZHKIN ALEXEJ NIKOLAEVICH
IPC: E03D1/34
Filed: 2009-06-19
Abstract: A flush valve is intended for toilet flush tank for providing a sell between the flush tank and the bowl. The valve comprises a seat (3) and a locking element (5). Both the seat and the locking element are made as a washer. The washer has several rows of projections arranged concentrically to the valve axis. The projections are shaped as a closed thin-walled strip and are spaced from each other. In the closed valve position the projections (4) of the seat (3) are positioned in gaps of the locking element (5), wherein the projections (6) of the locking element (5) in the gaps of the seat (3). The valve is sealed by forming airlocks between the projections (4) of the seat (3) and the projections (6) of the locking element (5).
Patent EA-018935-B1 (EA)
Title: Hcv nucleoside inhibitor
Inventor: JOHANSSON NILS-GUNNAR
IPC: A61K31/513
Filed: 2007-10-04
Abstract: 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyltetrahydrofuran-2-yl)-1H-pyrimidin-2-one (22) is hepatitis C (HCV) polymerase inhibitor. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.
Patent EA-020333-B1 (EA)
Title: Pharmaceutical composition comprising solifenacin or a pharmaceutically acceptable salt thereof
Inventor: ALLES RAINER
IPC: A61K9/20
Filed: 2008-07-23
Abstract: The present invention relates to a pharmaceutical composition comprising solifenacin or a pharmaceutically acceptable salt thereof and a process for the preparation of said pharmaceutical composition.
Patent EA-032702-B1 (EA)
Title: Cartridge for blood treatment, blood treatment apparatus for receiving the cartridge and cartridge filling method
Inventor: GRONAU SOEREN
IPC: A61M1/36
Filed: 2010-04-21
Abstract: Provided is a cartridge for blood treatment connected to a blood treatment apparatus and comprising at least one body frame, at least one chamber (9, 15, 21, 57) integrated into the body frame and adapted to receive medical fluids, at least one passage (17, 19, 49) integrated into the body frame for receiving and/or guiding a medical fluid, and at least one valve means (35, 36, 39, 40, 47, 51, 53, 61) integrated, completely or partly, into the body frame for controlling or regulating a fluid flow through the cartridge, wherein the cartridge is provided, at least on one of its surfaces, with a cover means that constitutes a part of said at least one integrated valve means (35, 36, 39, 40, 47, 51, 53, 61), the cover means is connected, at least at one its section, to the body frame so that forced and/or geometrical and/or non-detachable closure is provided, the cartridge has at least two pump hose segments (88, 90), or is connectable to at least two pump hose segments (88, 90), said at least two pump hose segments (88, 90) including a first pump hose segment to be inserted in a blood pump, and a second blood hose segment to be inserted in a substitute solution pump. Further provided are a blood treatment apparatus and a method for filling a blood treatment cartridge.
Patent EA-030414-B1 (EA)
Title: Methods for producing diketopiperazines and compounds containing diketopiperazines
Inventor: BAR-OR DAVID
IPC: C07K14/76
Filed: 2014-02-03
Abstract: Methods of making increased amounts of diketopiperazines (DKP) such as DA-DKP in pharmaceutical compositions of proteins and peptides are disclosed. The disclosure further provides methods of making a DKP, including (1) contacting albumin with an enzyme (such as a dipeptidyl peptidase IV (DPP-IV)) that cleaves a pair of N-terminal amino acids from the albumin, and (2) heating the albumin under conditions effective to cause the formation of the DKP. Further, treatment of DKP- and albumin-containing streams to produce improved, higher value, DKP compositions and purified albumin compositions for therapeutic uses is also disclosed. In addition to a first therapeutic DKP composition comprising a low albumin content, a second valuable therapeutic composition is also produced characterized by a high albumin concentration.
Patent EA-034644-B1 (EA)
Title: Use of cart19 to deplete normal b cells to induce tolerance
Inventor: LEVINE BRUCE L
IPC: A61K48/00
Filed: 2013-07-12
Abstract: The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
Patent EA-034865-B1 (EA)
Title: Spatial sampling improvements and the formation of arrays using popcorn and simultaneous source acquisition
Inventor: ABMA RAYMOND LEE
IPC: G01V1/28
Filed: 2015-03-13
Abstract: So-called "Popcorn shooting", and especially continuous Popcorn shooting, combined with simultaneous source shooting allows considerable flexibility in producing high-resolution data and in creating source arrays. Using a combination of simultaneous source de-blending and Popcorn reconstruction it is possible to construct using post acquisition processing arrays of any desired length by constructing a popcorn pattern that takes into account the vessel speed and physical arrangement of guns behind the towing vessel.
Patent EA-034924-B1 (EA)
Title: Oligomers and oligomer conjugates
Inventor: JAVANBAKHT HASSAN
IPC: C12N15/113
Filed: 2015-05-12
Abstract: The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
Patent EA-032273-B1 (EA)
Title: Module assembly used in a display device and display device
Inventor: HSIAO YU-CHUN
IPC: G09F9/00
Filed: 2014-07-07
Abstract: Provided is a module assembly used in a display device. The module assembly comprises a backboard, a heating member and a thermal expansion member. The heating member is fixed on a first surface of the backboard. The thermal expansion member is fixed on the heating member. The thermal expansion member has a first thermal expansion coefficient. The heating member is used for providing heat for the thermal expansion member. The thermal expansion member undergoes a first deformation based on the heat so that the backboard undergoes a second deformation. A display panel forms a desired curved surface display effect based on actual needs.
Patent EA-037412-B1 (EA)
Title: Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone marrow donors
Inventor: BADER PETER
IPC: C12N5/0775
Filed: 2015-07-14
Abstract: The invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared according to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disease (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.