Patent SG-11201807708S-A (SG)
Title: Estrogen receptor modulators
Inventor: HUANG PETER
IPC: C07D209/14
Filed: 2017-03-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M11111011101 11111111110101111101110101110111111111001111111111111110111111 International Bureau ... ..... ..Yi j (10) International Publication Number ...... ... (43) International Publication Date WO 2017/172957 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: Rakesh, Kumar; 10835 Road to the Cure, Suite 205, San C07D 471/04 (2006.01) C07D 209/14 (2006.01) Diego, CA 92121 (US). C07D 471/14 (2006.01) A61K 31/437 (2006.01) CO7C 61/13 (2006.01) A61K 31/438 (2006.01) (74) Agent: MALLON, Joseph, J.; Knobbe, Martens, Olsen & CO7F 7/18 (2006.01) A61P 35/00 (2006.01) Bear LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 CO7C 57/04 (2006.01) A61P 5/30 (2006.01) (US). CO7D 209/18 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/024809 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 29 March 2017 (29.03.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (25) Filing Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (30) Priority Data: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 62/317,254 1 April 2016 (01.04.2016) US ZA, ZM, ZW. (71) Applicant: KALYRA PHARMACEUTICALS, INC. (84) Designated States (unless otherwise indicated, for every [US/US]; 10835 Road to the Cure, Suite 205, San Diego, kind of regional protection available): ARIPO (BW, GH, CA 92121 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Peter, Qinhua; 10835 Road to the TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: HUANG, Diego, CA 92121 (US). SLEE, De- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Road to the Cure, Suite 205, San DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — Cure, Suite 205, San borah, Helen; 10835 HEGDE, Sayee, Gajanan; 10835 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = Diego, CA 92121 (US). 205, San Diego, CA 92121 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Road to the Cure, Suite 10835 Road to the Cure, Suite GW, KM, ML, MR, NE, SN, TD, TG). 92121 (US). BUNKER, Kevin, Published: HOPKINS, Chad, Daniel; = 205, San Diego, CA = Duane; 10835 Road to the Cure, Suite 205, San Diego, CA Joseph, Robert; 10835 Road with international search report (Art. 21(3)) PINCHMAN, 92121 (US). San Diego, CA 92121 (US). SIT, to the Cure, Suite 205, = = = = = MODULATORS = (54) Title: ESTROGEN RECEPTOR = R 6 R 4 7R 1) o = = = R6 ,, R20<5 R 4 — 2 R8 r - ‘\ : >,( 1 R I K Al O R s X 1 21 + I ,N 'L I x • yl R ° . • / Al x ' i 1 — ,NH R 1 Il OX 2 R 1 1 ,-`,. A B IN 0 X 2 R il in 0\ Formula (1) ei IN 11 FIGURE 1 IN 1-1 (57) : Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described Nin the disclosure. Such compounds, as wellpharmaceutically acceptable salts and compositions thereof, are useful for treating dis - as eases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions charac - Q terized by excessive cellular proliferation, such as breast cancer.