baber/WOPTO huggingface dataset:
Patent JP-3492368-B2 (JP)
IPC: C07F7/12
Filed: 1994-03-30
Granted: 2004-02-03
Abstract: PCT No. PCT/EP94/01001 Sec. 371 Date Nov. 15, 1995 Sec. 102(e) Date Nov. 15, 1995 PCT Filed Mar. 30, 1994 PCT Pub. No. WO94/22878 PCT Pub. Date Oct. 13, 1994Disclosed is an alkylating agent that contains an aluminum reagent Alk3-m AlLm, in which Alk means a methyl, ethyl, n- or i-propyl, n-, i- or tert-butyl, pentyl, hexyl, heptyl or octyl group, which all can also be branched, L means an ethoxy group, a chlorine or bromine atom, and m is equal to 1 or 2, as an alkyl source or else zinc dimethyl as a methyl source, which contains in addition catalytic amounts of one or more copper(I) and/or copper(II) compounds and one (or more) silyl reagent(s) of general formula IIIR1R2R3SiZ(III),in which R1, R2 and R3 are as defined herein, as well as a process for 1,4-addition of an alkyl group to an  alpha , beta -unsaturated ketone or an  alpha , beta -double unsaturated ketone or to an  alpha , beta -unsaturated aldehyde with use of the agent according to the invention. The alkylating agent yields biologically active compounds in excellent yields and the new alkylating agent/process is distinguished by its environmental compatibility based on a CKW (chlorinated hydrocarbon)-free reaction medium.
Patent JP-3307949-B2 (JP)
IPC: B27G13/04
Filed: 1996-04-25
Granted: 2002-07-29
Abstract: PCT No. PCT/EP96/01720 Sec. 371 Date Oct. 24, 1997 Sec. 102(e) Date Oct. 24, 1997 PCT Filed Apr. 25, 1996 PCT Pub. No. WO96/36452 PCT Pub. Date Nov. 21, 1996In a profiled inserted-blade cutter, with blades (13) which can be re-sharpened without altering the profile and trajectory, each blade (13) is secured to a blade holder (14) having a base with a T-shape cross section, one arm (16) of the transverse section of which engages in a first longitudinal groove (4) in the basic unit (2). The other arm (17) engages in a second longitudinal groove (5) also in the basic unit (2) and open towards the first groove (4). The flanks of the first and second longitudinal grooves (4, 5) at a greater distance from the central longitudinal axis of the basic unit (2) lie in planes which are mutually parallel and parallel to the longitudinal axis of the basic unit and each form a positioning surface (6, 7) for one or other arm (16, 17) of the transverse section. On the blade holder (14) there is a clamping surface (15) which encloses a radially outwardly opening angle with the frontal surface (13') of the blade (13) and an acute angle with the adjacent positioning surface (7). The clamping force of each clamping screw (21) is directed against the clamping surface (15) and presses the blade holder (14) with a first component against the frontal stop surface (9) and with a second component against the two positioning surfaces (6, 7).
Patent JP-4112001-B2 (JP)
IPC: C07D493/10
Filed: 1996-05-08
Granted: 2008-07-02
Abstract: PCT No. PCT/EP96/01919 Sec. 371 Date Aug. 5, 1997 Sec. 102(e) Date Aug. 5, 1997 PCT Filed May 5, 1996 PCT Pub. No. WO96/36622 PCT Pub. Date Nov. 21, 1996The present invention relates to novel 10-deacetyl-14 beta -hydroxybaccatine III derivatives. The novel derivatives, having cytotoxic and antitumour activity, are prepared from this synton after functionalization of the hydroxyls at 1-, 14- as thiocarbonate, iminocarbonate and sulfite and possible oxidation of the hydroxyl at C10. These derivatives are subjected to a subsequent esterification at position 13- with a variously substituted isoserine chain. The products of the invention can be administered by the injective or oral route, when suitably formulated.
Patent JP-3370340-B2 (JP)
IPC: A61P15/00
Filed: 1997-04-08
Granted: 2003-01-27
Abstract: The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.
Patent MD-2362-B2 (MD)
Title: Strain of Aspergillus niger fungi producer of lipolytic enzymes
Inventor: DESEATNIC-CILOCI ALEXANDRA
IPC: C12N9/20
Filed: 2001-09-13
Abstract: The invention refers to biotechnology, in particular to the strain of Aspergillus niger fungi, which may be used in the microbiological industry for lipolytic enzyme obtaining. The strain of Aspergillus niger fungi CNM FD 01 producer of lipolytic enzymes is deposited with the National Collection of Microorganisms of the Institute of Microbiology of the Academy of Sciences of the Republic of Moldova.The result of the invention consists in increasing the activity of lipolytic enzymes.
Patent ES-2214075-B2 (ES)
Title: Aparato de alarma antirrobo para motocicleta.
Inventor: SHIMMURA HIROYUKI
IPC: B60R25/00
Filed: 2001-01-29
Granted: 2005-04-16
Abstract: Aparato de alarma antirrobo para motocicleta. Finalidad: Permitir una estructura simple de un mecanismo de liberación de obturador de un soporte principal y la reducción de costos. Constitución: Se acciona un botón de operación 8 dispuesto debajo de un asiento para desbloquear una cerradura de almacenamiento de soporte principal 11 mediante un cable 9 cuyo extremo está conectado al botón de operación 8, por lo que es posible el almacenamiento del soporte principal 12, y un cable de derivación 13 derivado del cable 9 en una sección de unión 10 está conectado al mecanismo de liberación de obturador 4. El mecanismo de liberación de obturador 4 conecta un obturador 15 que cubre de forma soltable el agujero de introducción de llave 14 del soporte principal 2. Cuando la cerradura de almacenamiento de soporte principal 11 es desbloqueada por el botón de operación 8, el cable de derivación 13 es aflojado simultáneamente por la sección de unión 10 para girar el obturador mediante un muelle helicoidal de compresión 18, para abrir por ello el agujero de introducción de llave 14.
Patent ES-2392062-B2 (ES)
Title: Aditivo seco para yesos y procedimiento para su preparación
Inventor: MONEO PECO LUIS
IPC: C04B22/06
Filed: 2012-09-10
Granted: 2013-04-16
Abstract: Aditivo seco para yeso y procedimiento para su fabricación caracterizado por el hecho de que se compone de una base de ácido policarboxílico, más concretamente ácido cítrico, a la cual se le añade dióxido coloidal de silicona en proporción de entre un 0,8% y 1,2% del peso referido al ácido. El aditivo propuesto está presentado en forma de polvo seco, de manera que la mezcla con el yeso cuyas propiedades se pretenden mejorar se realizará antes de la mezcla con agua, pudiendo incorporar el aditivo en la masa seca de yeso durante su fabricación. El procedimiento para su obtención pasa por la disposición de una base de ácido cítrico presentado en forma de cristales sólidos a la que se le adiciona dióxido coloidal de silicona en la proporción indicada para posteriormente mezclarlo hasta la obtención de un color y unas texturas homogéneas.
Patent ES-2540164-B2 (ES)
Title: Sistema de unión desmontable y reconfigurable para perfiles de tubo cuadrado
Inventor: CABALEIRO NUNEZ MANUEL
IPC: F16B7/04
Filed: 2014-01-03
Granted: 2016-01-13
Abstract: Sistema de unión desmontable y reconfigurable para perfiles de tubo de sección cuadrada, sin necesidad de realizar ninguna operación previa sobre el perfil, en el que se une la cabeza de uno de los perfiles con el lateral del otro perfil, caracterizado por la utilización de bridas metálicas que constan de cuatro bridas con cartela (1) y cuatro bridas sin cartela (3) tornillos de sujeción (2) y tuercas (5). El mismo sistema de unión, debido a la regulación en los tornillos (2), sería válido para diferentes tamaños de secciones de perfiles de tubo cuadrado. Las bridas están provistas de un estriado interior. La combinación de este estriado con la forma de ajustarse las bridas en las cuatro esquinas del perfil, permite aumentar considerablemente la fuerza de amarre de las bridas a las paredes del perfil de tubo cuadrado debida a la precarga de los tornillos. Con este sistema de amarre en la unión se puede transmitir mayor esfuerzo cortante del perfil no pasante (6) al perfil pasante (4).
Patent ES-2575711-B2 (ES)
Title: Método para la obtención de láminas de grafeno
Inventor: LOPEZ QUINTELA MANUEL ARTURO
IPC: C01G41/00
Filed: 2014-12-31
Granted: 2016-11-03
Abstract: Método para la obtención de láminas de grafeno.#La presente invención se refiere a un procedimiento para obtener láminas de grafeno, de nitruro de boro hexagonal, de disulfuro de molibdeno, de disulfuro de tungsteno o láminas de mezclas de los mismos a partir del polvo de dichos materiales. Dichas láminas están formadas por un conjunto de tiras, donde dichas tiras consisten en de una a cinco capas. Dichas capas son capas de grafeno, nitruro de boro hexagonal, disulfuro de molibdeno o disulfuro de tungsteno que tienen un grosor monoatómico o monomolecular. Además, la invención se refiere a un procedimiento para recubrir una superficie con láminas de grafeno, de nitruro de boro hexagonal, de disulfuro de molibdeno, de disulfuro de tungsteno o láminas de mezclas de los mismos.
Patent IE-S86415-B2 (IE)
Title: Gravitational potential energy storage
Inventor: MCGRATH BRENDAN
IPC: F03B13/00
Filed: 2014-02-26
Abstract: An energy storage system comprises a cable (13) 13 and a mass 20 suspended from the cable (13) in a shaft (12) 12. the cable (13) is attached to a winch 11 by which the mass may be raised in the shaft (12) to store potential energy, and the mass is lowerable in the shaft (12) to release the potential energy. the mass comprises at least two sections clamped together around the cable (13) 13. More particularly, the system comprising a plurality of cable (13)s and a plurality of multi-section masses each suspended in the shaft (12) by a respective cable (13), the masses being raised and lowered in synchronism in the shaft (12). The multi-section masses fit together side-by-side in the shaft (12) to form an overall cylindrical mass body, the multi-section masses each forming a quadrant of the cylindrical mass body. <Figure 4>
Patent AU-2001255475-B2 (AU)
Title: Method of reducing side effects of chemotherapy in cancer patients
Inventor: TAM VINCENT CHUNG-YIN
IPC: A61K33/243
Filed: 2001-04-19
Granted: 2006-01-05
Abstract: A method for reducing the severity of chemotherapy side effects in cancer patients by administering thymosin alpha1 in conjunction with the administration of a chemotherapy agent to the patient. As a result of the reduction of post-chemotherapy side effects, patients experience an increase in the quality of life.
Patent AU-2001284191-B2 (AU)
Title: Transdermal pharmaceutical delivery composition
Inventor: TUCKER ARTHUR TUDOR
IPC: A61P5/00
Filed: 2001-08-30
Granted: 2006-02-16
Abstract: A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.
Patent AU-2001295352-B2 (AU)
Title: Sealing device for drink packages
Inventor: LAGLER LOUIS
IPC: B65D51/16
Filed: 2001-10-22
Granted: 2008-07-31
Abstract: The invention relates to a sealing device (3, 30) for sealing off an opening (5) of a plastic drink package. Said sealing device (3, 30) has a flexible collar (10) that is provided with an inward-facing surface (45) that is subject to the internal pressure. The collar (10), in the closed position of the sealing device (30), is functionally linked with a collar rim (11) of the opening (5) to be sealed off and is adapted to exert a pressure (K) thereon that increases in proportion to the internal pressure (P).
Patent AU-2002221000-B2 (AU)
Title: Revolvable plug and socket
Inventor: KOHEN RAN
IPC: H01R39/00
Filed: 2001-11-22
Granted: 2008-02-28
Abstract: The invention relates to the support of light electric appliances such as light fittings and small fans. The device (Fig. 2) accoring to the invention provides a plug (12) and socket (10) combination powering and supporting an appliance in a manner allowing the user to change its orientation. The combination is particularly useful where there is a frequent need to move light appliances from one location to another. The combination comprises a fixable socket (20) and a plug (12) revolvable therein for conducting electric power and for mechanically supporting in a desired orientation an appliance receiving the power.
Patent AU-2002304254-B2 (AU)
Title: Metal plate for producing flat tube, flat tube and process for producing the flat tube
Inventor: HOSHINO RYOICHI
IPC: F28F1/04
Filed: 2002-06-06
Granted: 2008-05-29
Abstract: A metal plate (40) for use in producing a flat tube comprising a pair of flat walls opposed to each other, two side walls interconnecting opposite side edges of the two flat walls, and a plurality of reinforcing walls interconnecting the flat walls, extending longitudinally of the tube and spaced apart from one another by a predetermined distance, 
the metal plate (40) comprising two flat wall forming portions (12;13) connected together by a joint portion (11), a plurality of reinforcing wall forming portions (14;15) upwardly projecting from each of the wall forming portions (12;13) integrally therewith, and a side wall forming portion (16;17) formed at each of opposite side edges of the plate and upwardly projecting therefrom integrally therewith, the joint portion (11) having a larger thickness than the flat wall forming portions (12;13).
Patent AU-2002322344-B2 (AU)
Title: Fluoropyrrolidines as dipeptidyl peptidase inhibitors
Inventor: RANDHAWA AMARJIT SAB
IPC: C07D277/06
Filed: 2002-06-26
Granted: 2005-08-11
Abstract: The present invention relates to novel compounds, their use for inhibiting serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV) and to methods for their production and their therapeutic utility.
Patent AU-2002326256-B2 (AU)
Title: Micro needles and method of manufacture thereof
Inventor: STEMME GORAN
IPC: A61M5/32
Filed: 2002-08-14
Granted: 2008-05-22
Abstract: A hollow out-of-wafer-plane micro-needle protruding from a support member, the micro-needle includes a body portion having a longitudinal central axis, an inner lumen within the body portion and extending through the support member and into the protruding micro-needle, a closed pointed tip portion closing off the inner lumen in the tip region, the central axis extending through the tip portion, and at least one side opening in the body portion having an axis that intersects the central axis, the at least one side opening communicating with the inner lumen.
Patent AU-2002348703-B2 (AU)
Title: Roll diaphragm control valve
Inventor: WEINGARTEN ZVI
IPC: F16K41/12
Filed: 2002-10-28
Granted: 2007-10-11
Abstract: The present invention provides an improved diaphragm control valve with a simplified construction that has significant advantages over prior art diaphragm control valves. Further, the present invention provides substantially straight-through fluid flow which enables a high flow capacity with minimal pressure loss. The non-planar diaphragm of the present invention, when standing in a non-stressed state, is substantially an annulus that assumes a shape with a cross section that extends from a first attachment bead substantially radially in a first direction through a first curve continues substantially non-radially in a second direction through a second curve and continues in a substantially radial direction terminating in a second attachment bead, such that the diaphragm does not fold back on itself. That is to say, the diaphragm is both axially non-overlapping and rotationally symmetrical.
Patent AU-2002359288-B2 (AU)
Title: Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
Inventor: ORAL ELIF ARIOGLU
IPC: A61K38/22
Filed: 2002-10-22
Granted: 2008-07-31
Abstract: Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipodystrophy. Leptin is effective against lipodystrophy conditions for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including in a vector comprising nucleic acid sequences encoding leptin. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having approximately 4ng/ml or less before treatment.
Patent AU-2002367387-B2 (AU)
Title: Vascular access device
Inventor: TAL MICHAEL
IPC: A61M5/178
Filed: 2002-12-24
Granted: 2009-05-21
Abstract: A vascular access device includes a needle section (102; 142) and a dilator section (112; 150). The dilator is coaxially mounted on the needle forming a space (122; 170) between the needle and the dilator and arranged so that blood flowing in the needle (104; 144) flows into the space (122; 170) through at least one lateral opening (120; 149) in the needle. Optionally, a sheath section (160) comprising a sheath (162) is coaxially mounted on the dilator (152) optionally forming a second space (174) between the dilator (152) and the sheath (160), the dilator in this case being provided with an opening (172) or spaces arranged so that blood flowing in the needle (144) and then through the lateral opening (149) flows into the second space (174). One or more small openings, pores or spots of porous material on the dilator, or a porous vent (128) on the dilator hub (116; 154), allows air or gas to escape from the space (122; 170), or when present the second space (174), yet retain blood. The dilator (114; 152) or the sheath (162) is clear, semi-opaque, or translucent, so that when blood flows into needle (104; 144) and then into the space (122; 170) or when present the second space (174) may be seen to indicate that the distal tip (124; 176) of the needle (104; 144) has punctured a blood vessel.
Patent AU-2003211146-B2 (AU)
Title: Controlled release dosage forms
Inventor: ZHOU FANG
IPC: A61K47/14
Filed: 2003-02-21
Granted: 2007-07-19
Abstract: The invention provides stable controlled release monolithic coating compositions for use in coating pharmaceutical oral dosage forms comprising a polyglycol having a melting point greater than 55° C. and an aqueous dispersion of a neutral ester copolymer lacking functional groups.
Patent AU-2003250115-B2 (AU)
Title: Inversion of the negative-selective effect of negative marker proteins using selection methods
Inventor: BADUR RALF
IPC: C12N9/12
Filed: 2003-07-18
Granted: 2009-03-12
Abstract: Method for preparing transformed plant cells or organisms. Method for preparing transformed plant cells or organisms comprises first transfecting a population of plant cells, already containing at least one marker protein (MP) that can exert a direct or indirect toxic effect, with at least one nucleic acid sequence (A) together with at least one compound (I) able to reduce expression, amount, activity and/or function of MP. Transfected cells that contain (A) in their genome and, because of the activity of (I) have a growth advantage relative to non-transformed cells are selected, under conditions where MP exerts its toxic effect on non-transformed cells. Independent claims are also included for the following: (1) plant-derived 5-methylthioribose kinase (MRTK) having any of 5 sequences (134-327 amino acids) reproduced; (2) nucleic acid (II) encoding MRTK and having any of 5 sequences (404-1011 nucleotides) reproduced; (3) double-stranded RNA (III) comprising a sense strand (ss) essentially identical with at least part of the sense transcript of nucleic acid that encodes MP and an antisense strand essentially, best completely, complementary with ss; (4) transgenic expression cassette (EC) containing: (a) a promoter (P) functional in plants and a sequence (IV) that encodes (III); or (b) a sequence encoding at least part of MP, linked to P in the antisense orientation; (5) transgenic vector containing EC; and (6) transgenic plant containing (III), EC or the vector of (5), also derived tissue, organs, parts, cells, cell cultures and reproductive material.
Patent AU-2004285337-B2 (AU)
Title: Animal harness
Inventor: MUGFORD ROGER ARTHUR
IPC: A01K27/00
Filed: 2004-10-22
Granted: 2011-05-12
Abstract: A harness for a quadruped animal including a chest strap which in use of the harness lies across the chest of the animal in front of the forelegs, the harness including an attachment for a leading strap, the attachment being slidably mounted on the chest strap for movement therealong. Each end of the chest strap is attached to a trunk loop which in use of the harness passes around the trunk of the animal behind the forelegs. The trunk loop includes a back strap which in use of the harness lies across the back of the animal affixed to a lower strap which in use of the harness passes under the animal behind the forelegs.
Patent AU-2004312154-B2 (AU)
Title: Lift system
Inventor: ACH ERNST
IPC: B66B7/06
Filed: 2004-12-27
Granted: 2010-03-04
Abstract: Lift comprising a drive unit that drives a lift car by means of a drive belt running over a pulley comprises a drive belt (12.1) that has parallel longitudinal ribs (20.1) of wedge-shaped or trapezoidal cross-section on the side facing the pulley and cables (22) distributed over the width of the belt so that there is the same number of cables for each rib, the outer cable of each rib being located within the perpendicular projection (P) of a flank of the rib.
Patent AU-2004312632-B2 (AU)
Title: Keyboards
Inventor: MCPHEE PURCOCKS DALE
IPC: G06F3/02
Filed: 2004-12-06
Granted: 2011-11-10
Abstract: A switch comprising a generally tubular housing (10) of a rigid plastics material. A plurality of discrete tabs (12) are circumferentially disposed, in side-by-side relation, around an end of the housing (10). The housing (10) defines a recess (16) for receiving an elastomeric dome member (24) having an annular rib (26) at its base, and the recess (16) has an annular groove (20) with a relatively sharp edge (22) for receiving the annular rib (26) of the dome member (24). When the dome member (24) is correctly inserted within the recess (16), a downward force is provided on the tabs (12), causing them to `fold' down over the base of the dome member (24), such that they are substantially at right-angles to the longitudinal sidewall of the housing (10), and substantially flush with the edge portion (29) thereof. Optionally, heat may also be applied to the tabs (12), causing them to at least partially soften and melt together, to form a single, substantially integral, flange completely covering the annular rib (26) at the base of the dome member (24), so as to create a fluid-tight seal between the housing (10) and the dome member (24). The end of the housing (10) opposite to that having the tabs (12) is provided with an aperture (30) with which the stem (32) of a keycap 34 is slidably engaged. The recess (16) for receiving the dome member (24) is shaped and configured so as to provide sufficient clearance such that the dome member (24) does not contact the inner wall of the housing (10) when it is deformed in use.