baber/WOPTO huggingface dataset:
Patent IL-136667-A0 (IL)
Title: Methods of producing anti-angiogenic proteins: endostatin, angiostatin or restin, using a pichia yeast expression system
IPC: A61K35/28
Filed: 1998-12-08
Abstract: Methods for making proteins with anti-angiogenic properties are disclosed, including angiostatin, endostatin and restin. The system used is a yeast expression system which produces biologically active proteins at high titer, specifically the Pichia pastores yeast expression system.
Patent IL-148050-A0 (IL)
Title: Crystals of the sodium salt of pravastatin
IPC: C07C69/732
Filed: 2000-08-04
Abstract: Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, fluvastatin and cervastatin and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicillium genus, some are obtained by treating the fermentation products using the methods of chemical synthesis (simvastatin) or they are the products of total chemical synthesis (fluvastatin, atorvastatin and cervastatin). The present invention relates to a crystalline form of the sodium salt of pravastatin, which is known by the chemical name 1-naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, mono sodium salt, which is useful as a pharmaceutical substance. The present invention further relates to the method for its preparation and isolation, to a pharmaceutical formulation containing the sodium salt of pravastatin in the crystalline form and a pharmaceutically acceptable carrier, and to a pharmaceutical method of treatment. The novel crystalline form of the sodium salt of pravastatin is useful in the treatment of hypercholesterolemia and hyperlipidemia.
Patent IL-155208-A0 (IL)
Title: Wet/dry automatic injector assembly
IPC: A61M5/31
Filed: 2001-10-10
Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, an activation assembly and a needle assembly for dispensing a dissolved medicament to a user. A dry compartment for storing a predetermined dry charge of dry medicament is located within the interior chamber. A wet compartment for storing a predetermined amount of liquid injection solution is also located within the interior chamber. A separation assembly separates the dry compartment from the wet compartment. The separation assembly prevents transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device. One or more medicament support assemblies located within the dry compartment prevent the passage of undissolved medicament from the dry compartment.
Patent IL-172419-A0 (IL)
Title: Piperazine derivatives and methods of use
IPC: C07D413/14
Filed: 2005-12-06
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Patent IL-182007-A0 (IL)
Title: Method for ex-vivo purging in autologous transplantation
Filed: 2007-03-19
Abstract: The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of FasL to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (ASCT) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating Hodgkin's disease. Such therapy is nowadays also contemplated for selected patients with low-grade lymphomas (chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma) and for patients with acute myeloid leukemia (AML). Current treatments for cell purging include chemotherapy and antibody cocktails. These treatments are often toxic on stem cells and not efficient in eliminating cancer cells. Thus, there is an unmet medical need for cell purging in ASCT which this project will address.
Patent IL-193631-A0 (IL)
Title: Humanized antibodies that sequester amyloid beta peptide
IPC: A61K39/00
Filed: 2008-08-21
Abstract: A method to treat conditions characterized by formation of amyloid plaques both grophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aß peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aß.
Patent RO-126811-A0 (RO)
Title: Field effect transistor of the cavity-on-insulator type and process for making the same
Inventor: RAVARIU CRISTIAN
IPC: H01L29/772
Filed: 2010-11-18
Abstract: The invention relates to a field effect transistor of the cavity-on-insulator type and to a process for making the same. According to the invention, the transistor comprises a silicon substrate (1) coated with a silicon oxide layer (2) on top of which there is placed a p-type silicon layer (10), on the silicon oxide layer (2) there being placed two high and n-doped semiconductor islands (3, 4) connected to each other by means of a p-type semiconductor film (9) having a thickness of less than 4 nm, above which there is allowed the presence of a vacuum cavity (5) occupying the whole space between the nislands (3, 4) which are connected to a source terminal (6) and a drain terminal (7), while on the back of the structure (1) there is placed a gate terminal (8). The process claimed by the invention comprises the following stages: selecting a silicon-on-insulator structure with a single-crystal initial layer, applying layer thinning techniques, then, within a first masking operation, defining some nislands, namely a source one and a drain one, controlled-doped with donor impurities, followed by a second masking operation, namely etching the p silicon layer and laying the metal contacts, within a third masking operation, on the nregions for the source and drain terminals and on the back of the structure for the gate terminal, the final stage comprising the operations of cutting out, sealing and encapsulation.
Patent RO-127338-A0 (RO)
Title: Device for determining the wear resistance of nitrocarburated layers
Inventor: OLAH ARTHUR
IPC: G01N3/56
Filed: 2011-11-24
Abstract: The invention relates to a device for determining the wear resistance of materials, in general, and of nitrocarburated layers, in particular. According to the invention, the device comprises an upper part (3) fixed within a rotating shaft of a drilling machine, by means of a Morse cone, comprising a circular test piece (16) and a lower part fixed on a table of the drilling machine, consisting of a bushing (8) which comprises a measuring rule (9) and an indicator (10) fixed on a calibrated spring (14) to determine the pressing force, a ball (13) ensuring the horizontality of some friction surfaces, where, upon lowering the upper part (3), the test piece (16) comes into contact with a metal carbide plate (12) and the friction takes place by rotation of the upper part (3), in case of intense friction there being provided a water cooling system comprising a collecting vessel (6), a water hose (5) which injects water to the upper part (3) and a vessel (7) for recycling the cooling water.
Patent RO-128851-A0 (RO)
Title: Ejector-type turbine
Inventor: PUSCAS CERNAT MIHAIL
IPC: F03D9/00
Filed: 2013-05-09
Abstract: The invention relates to an ejector-type turbine meant to convert kinetic energy of a fluid into mechanical and/or electric energy , by capturing and accelerating a motive fluid jet. According to the invention, the turbine comprises an air intake provided with a system (1) for closing and adjusting the flow rate of captured fluid, in direct connection with a confuser (2) where the stream of the captured fluid is accelerated and sent as motive fluid jet by means of a supply pipe (3) in an ejector-type device where the motive fluid jet is expanded through a nozzle (4) into a suction chamber (5) and is subsequently released together with the fluid ejected into the atmosphere through a discharge device (6), in the suction chamber (5) there being an annular turbine consisting of an annular rotor (7) and an annular stator (8) for directing the sucked fluid to the rotor, the jet of sucked fluid named ejected fluid acting upon the blades of the rotor (7) which drives an electricity generating system by means of a toothed crown (9) or a gin (10) mounted on the outer circumference of the rotor, and depending on the manner of using and the working fluids there are also provided a pivoting support (12) equipped with a system (13) for supporting and maintaining the air intake (13) for facing the wind, mounted on a supporting tower (14), if the installation is used as a wind turbine, a piping (15) and/or a careening (16) meant to efficiently take over and direct the air outside the motor vehicle body towards the elected fluid suction intake, a fixing and/or anchoring support (17) meant to ensure the installation to be fixed on the superstructure of the sea vessels, in case of the auxiliary wind generator, and some valves (18, 19) meant to ensure the stopping/starting of the installation and the adjustment of the fluid flow and also the support (17) meant to ensure the fixation of various other structures, in case of the steam or hydraulic turbine.
Patent AP-2000001952-A0 (AP)
Title: Method for treatment of top soil of a field with ozone gas to increase growth of plants.
Inventor: PRYOR ALAN
IPC: C02F1/78
Filed: 1999-03-08
Abstract: An ozone containing gas is injected into top soil that was previously oversaturated with water. The ozones oxides molecules in order to produce a byproduct which is beneficial to the growth of plants or beneficial fungi, e.G. trichoderma
Patent AP-2001002350-A0 (AP)
Title: Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2.2.2]octo-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate as nk-1-receptor antagonists.
Inventor: QUALLICH GEORGE J
IPC: A61P25/28
Filed: 2000-05-17
Abstract: Two crystalline polymorphic forms of (2-benzhydryl-1-azo-bicyclo[2.2.2.]Oct-3-yl)-(5-isopropyl-2-methoxybenzl)-amine citrate monohydrates)are form a and form b. The pharmaceutical composition containing at least one ofthese polymorphs has advantageous stability for formulation to treat acute emesis in patient receiving chemotherapy. A method of making a and b forms is also disclosed
Patent AP-2003002924-A0 (AP)
Title: 2,5-diarylpyrazines, 2,5 - diarylpyridines and 2,5 - diarylpyrimidines as CRF1 receptor modulators
Inventor: HUANG JIANHUA
IPC: G01N33/58
Filed: 2002-05-22
Abstract: Diarylpyrazine, diaryIpyridine, and diarylpyrimidine compounds that act as selective modulators ofCRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharma-ceutical compositions are also provided. Compounds of formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
Patent AP-2004003072-A0 (AP)
Title: Fencing system
Inventor: KUNITZ WALTER MANFRED
IPC: E04H/
Filed: 2002-12-18
Abstract: This invention provides a fencing system (10) comprising a plurality of spaced apart parallel extending upright posts (12): a plurality of horizontally extending bearers (14); and a plurality of parallel extending uprights (16). First connecting means (18) connects the bearers (14) to the posts (12) and second connecting means (20) connects the uprights (16) to the bearers (14). Each post (12) defines an elongate channel 12.1, and is provided with a cover 12.2 connected to the post (12) by a fourth connecting means (22), for closing the channel 12.1. Posts (12) located in a central region of the fencing system (10) are adapted to receive a supporting insulator (24), for supporting ' an electrified conductor (26). A carrier (28) is connected to comer posts (12) by third connecting means and includes a carrier (28) with connecting formations 28.2 for connecting to an insulator (30) for carrying electrified conductors (26).
Patent MC-1935-A1 (MC)
Inventor: T A KRENITSKY
IPC: A61K31/708
Filed: 1988-05-27
Abstract: The present invention relates to certain substituted purine arabinosides and their pharmaceutically acceptable derivatives especially esters and their use in the treatment and prophylaxis of varicella zoster virus and cytomegalovirus infections. The invention also includes pharmaceutical formulations and processes for the preparation of such compounds.
Patent ZW-6884-A1 (ZW)
Title: Non-toxinogenic vibrio cholerae mutants
Inventor: MEKALANOS JOHN J
IPC: C12N5/00
Filed: 1984-04-26
Abstract: Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. The modified strains are useful as live or dead oral vaccines.
Patent LU-88076-A1 (LU)
Title: Dispenser for spreading even layer of powdered material - comprises pivoted distribution trough on cage rotated by wheels with sealed bearings
Inventor: LONARDI EMILE
IPC: B65G69/04
Filed: 1992-03-04
Abstract: The dispenser consists of a distribution trough (10) pivoted to a cage (12) at an adjustable angle. The cage is suspended from a ring (22) which is supported vertically and guided laterally by three wheels (24) set at intervals of 120 deg. to one another. The cage also has a peripheral toothed crown wheel (30) which engages with an endless chain (32) used to rotate the cage. The three wheels (24) have recessed rims; they can be moved radially relative to the cage ring (22) to engage or disengage them, and have bearings in sealed housings with a lubricant. In a variant of the design, two of the wheels can be fixed and the third movable by means of a cam and spring mechanism.
Patent MA-28056-A1 (MA)
Title: Boite a lettre intelligente avec une boite de messagerie hybride
Inventor: KADA AHMED
Filed: 2005-01-19
Abstract: KADA AHMED BOITE A LETTRE INTELLIGENTE avec une boite de messagerie hybride La Boîte à Lettre Intelligente (BL1) est une boite à lettre capable de communiquer des informations sur son contenu à son détenteur via des supports de télécommunication, des moyens de communication électroniques, sonores et/ou visuelle, mécaniques ou hybrides. Cette communication est réalisée via un processus qualifié qui détaille le contenu de la boite selon le type des objets qu'elle contiennent. (par exemple elle peut informer son détenteur, via un moyen de communication choisi, qu'il a dans sa boite à lettre XI journaux, depuis la date jj1/mm1/aa1 à HH1 heures et MN1 minutes, X2 lettres ordinaires depuis la date jj2/mm2/aa2 à HH2 heures et MN2 minutes, X3 avis de paiement de mandat depuis la date jj2/mm2/aa2 à HH2 heures et MN2 minutes,..). L'interface d'accès à l'information délivrée par la BL1 est un boite de messagerie hybride qui permet au détenteur de réceptionner et d'envoyer des emails via l'Internet et de pouvoir consulter électroniquement le contenu de son boite à lettre.
Patent MA-27290-A1 (MA)
Title: Document securise par une matiere opaque aux infrarouges
Inventor: DUMERY THIERRY
IPC: D21H21/48
Filed: 2005-02-15
Abstract: Le document sécurisé comporte au moins un élément de sécurité comprenant au moins une zone ayant une couleur n'entraînant pas ou peu d'inclusion d'un composant opaque aux infrarouges lors d'une reproduction par photocopie, et au moins un signe de sécurité s'étendant dans cette zone, le signe de sécurité étant réalisé avec une matière de sécurité opaque aux infrarouges mais ayant une couleur n'entraînant pas ou peu d'inclusion d'un composant opaque aux infrarouges lors d'une reproduction par photocopie.
Patent MA-28043-A1 (MA)
Title: Procede de traitement de la peau d'animaux
Inventor: BERKHOUT HERMANUS JOHANNUS
IPC: C14C1/08
Filed: 2006-03-16
Abstract: L'invention concerne un procédé permettant de dégraisser et/ou de sécher la peau des animaux, qui consiste à mettre cette peau en contact avec un ou plusieurs solvants extracteurs comprenant au moins un solvant choisi dans le groupe formé d'éther diméthylique (DME), de méthylal, de dioxolanne, d'éther diéthylique et de méthyle éthyle cétone. De préférence, DME est le solvant extracteur.
Patent MA-38364-A1 (MA)
Title: Composés imidazopyridazines substitués
Inventor: SIEMEISTER GERHARD
IPC: C07D487/04
Filed: 2014-02-25
Abstract: La présente invention concerne des composés imidazopyridazines substitués, des procédés de préparation desdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés et l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique pour le traitement ou la prophylaxie d'une maladie, en particulier un trouble hyper-prolifératif et/ou un trouble de l'angiogenèse, en tant qu'agent unique ou en combinaison avec d'autres principes actifs.
Patent MA-39544-A1 (MA)
Title: Procédé et installation de traitement d'un mélange de déchets incluant une séparation et un compostage dudit mélange
Inventor: CHARREYRE FABIEN MICHEL ALAIN
IPC: C05F17/02
Filed: 2015-05-23
Abstract: - l'invention concerne une installation et un procédé de traitement d'un mélange de déchets (2), ces derniers étant de tailles, de formes et de consistances hétéroclites, le procédé de traitement étant caractérisé en ce qu'il comporte les étapes successives suivantes : - étape e1 au cours de laquelle on sépare le mélange de déchets (2) en une première fraction de déchets (13) dont la taille est inférieure à environ 180 mm, de préférence inférieure à 140 mm, par l'intermédiaire d'une première série d'orifices de séparation (7,8) et en une deuxième fraction résiduelle de déchets (14), ladite première série d'orifices de séparation (7,8) comprenant des orifices primaires (7) et des orifices secondaires (8) dont la taille est supérieure à la taille des orifices primaires (7) de sorte que le mélange de déchets (2) est d'abord mis en contact avec les orifices secondaires puis avec les orifices primaires (7), - étape e2 au cours de laquelle on fait subir un processus de compostage à la première fraction de déchets (13) de manière à composter au moins en partie les déchets biodégradables qu'elle contient.
Patent MA-42342-A1 (MA)
Title: Procédé de communication basé sur la classification des chemins multiples
Inventor: HABBANI AHMED
IPC: H04W40/00
Filed: 2018-04-27
Abstract: Notre invention apporte une solution optimale, fiable et rapide pour un réseau ad hoc hétérogène composé de différents dispositifs appartenant à des réseaux (manet, vanet, fanet) ayant des caractéristiques différentes et chacun a son propre langage de communication. Cette invention propose un protocole de routage commun qui permettra la communication entre les différents éléments sans modifier leurs propriétés. L'échange d'information entre une source et une destination est assuré à travers plusieurs itinéraires calculés et classifiés suivant les caractéristiques des nœuds hétérogènes impliqués dans le routage. Il permet aussi le choix de chemin de transmission selon la nature des données (critique, préventive et informative) en respectant la priorité et l'importance des données à transmettre.
Patent UY-25179-A1 (UY)
Title: Nuevos derivados de 2-(3h)-oxazolona
Inventor: CRESPO MARIA ISABEL CRESPO
IPC: A61P35/00
Filed: 1998-09-11
Abstract: Esta invención se relaciona con nuevos derivados de 2-(3H)-oxazolona de fórmula (I) útiles terapéuticamente, o procesos para su preparación y a composiciones farmacéuticas que los contienen. Compuestos de fórmula (I), en donde: R1 es un alquilo o un grupo amino; R2 es un naftilo, un grupo fenilo no sustituido o sustituido desde 1 a 3 átomos de halógeno (preferiblemente cloro, bromo o flúor) o grupos alquilo, alcoxi o trifluorometilo; y R3 es hidrógeno o un grupo alquilo. Un compuesto preferido es el compuesto de fórmula (II). Los compuestos de fórmula (I) son inhibidores selectivos y potentes de COX-2. Presentan una importante actividad antiinflamatoria. Se utilizan para tratamiento del dolor, fiebre o inflamación de una variedad de condiciones incluyendo fiebre reumática, síntomas asociados con la influencia y otras infecciones virales, catarro común; para inhibir la contractura muscular suave inducida de prostanoida o para la prevención de cáncer colorectal, entre otras.
Patent UY-25678-A1 (UY)
Title: Método para construcción de edificios y los componentes que lo hacen posible
IPC: E04B2/84
Filed: 1999-08-24
Abstract: Método para construcción de edificios y los componentes que lo hacen posible, caracterizado por comprender como primer paso de realización, la confección de cada panel (muro o losa) en un molde desarmable dispuesto horizontalmente en el propio obrador, sobre una superficie lisa y nivelada, utilizando como piso de dicho molde, de dimensiones equivalentes a la totalidad de las de cada panel, un lecho de material desmoldable sobre el que se ubican perfiles destinados a conformar molduras, si las hubiera, cajones fenólicos determinantes de vanos, accesorios de anclaje, cajas de luz, etc, rociando por encima de ellos una caap de desmoldante parafínico desplegable y/o aceite desmoldante, para luego posicionar la armadura, formando los cáncamos de izaje y las instalaciones internas tales como electricidad; paso seguido, se procederá al llenado y vibrado de material constitutivo, repitiendo la operación en sucesivos estratos apilados, para una vez fraguados los paneles, encarar el paso destinado a su montaje, izándolos por los cáncamos previstos en el moldeado, hasta posicionarlos en el armado mecánico del edificio, por la unión de sus insertos metálicos con planchuelas soldadas, para, en el paso final realizar el llenado de las uniones con el material consolidante y las juntas correspondientes.
Patent UY-26058-A1 (UY)
Title: Compuestos utiles como antiinflamatorios ley 17.164 art. 127
Inventor: BETAGERI RAJASHEHAR
IPC: C07D307/52
Filed: 2000-03-10
Abstract: Se describen nuevos compuestos aromáticos que son útiles en composiciones farmacéuticas para tratar enfermedades o estados patológicos que implican inflamación tales como enfermedades inflamatorias crónicas. También se describen procedimientos para preparar tales compuestos.
Patent UY-26795-A1 (UY)
Inventor: KEANE LAWRENCE
IPC: A61M13/00
Filed: 2001-06-25
Abstract: A new and improved inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler.