baber/WOPTO huggingface dataset:
Patent CA-2431566-A1 (CA)
Inventor: KRYGER ABRAHAM
IPC: A61K31/56
Filed: 2001-12-11
Abstract: L'invention concerne une formulation topique de testostérone. Selon un aspect de l'invention, cette formulation peut comprendre une quantité thérapeutiquement efficace de testostérone micronisée, un ingrédient arginine, et un ingrédient tocophérol mélangé avec un organogel de lécithine poloxamérique . On peut également ajouter des ingrédients supplémentaires, tels que la mélatonine, l'oxytocine, la déhydroépiandrostérone, et la progestérone.
Patent CA-2433707-A1 (CA)
Inventor: PRINSEN PHILLIP M
IPC: A61C19/06
Filed: 2002-01-10
Abstract: This portable appliance can be used to clean teeth by a liquid containing dissolved ozone.Preferably, its cleaning action is enhanced by pulsations of the liquid stream. The dissolved ozone can reduce or eliminate gingivitis, gum bleeding, bad breath, teeth stains, and harmful oral bacteria. This appliance can also be used for nasal irrigation for sinusitis treatment and for ear irrigation, eye care, and general cleaning. Additionally, since its output pump (34) is independent of the ozone dissolving system (19), the ozone dissolving system can be configured as an add on device for an oral irrigator such as a Water PikTM. In this configuration, the ozonated liquid is delivered by either gravity or pumped flow, to a reservoir in connection with the irrigator (35) that serves as the delivery portion of this invention.
Patent CA-2439416-A1 (CA)
Inventor: SMOLAREK HANNA MARIA
IPC: F16B39/282
Filed: 2001-03-09
Abstract: A washer (390) for a threaded fastener assembly and a threaded fastener assembly (100) incorporating such a washer. The washer (390) comprises a bod y having a central axis including two opposed sides (391, 392) an outer periphery (393) and an inner periphery defining a central aperture (394) extending between the two opposed sides. The body incorporates an engaging face (396) for frictionally engaging a component of the threaded fastener assembly or a work-piece. A ramp structure (340) extends angularly between t he inner periphery and one side (392) for interacting with a further component of the threaded fastener assembly to provide a mechanical connection therebetwe en for resisting unthreading of the threaded fastener assembly. The engaging fa ce (396) is associated with the other side (391) and extends circumferentially about the central axis. The relative positions of the engaging face (396) an d the ramp structure (340) with respect to the central axis is such that in us e torque transferred through the engaging face (396) is greater than torque acting through the ramp structure (340). With this arrangement, unwanted loosening of the threaded fastener assembly (100).
Patent CA-2439493-A1 (CA)
Inventor: BOUCHARD CLAUDE
IPC: G01F25/00
Filed: 2002-02-26
Abstract: Un limnimètre à bulles ayant un tube pneumatique (2) relié à un générateur d e gaz (12) et à un capteur de pression (14). Une valve de déviation (16) est interposée le long du tube pneumatique, permettant de dévier la sortie d'air à une hauteur prédéterminée de la sortie inférieure habituelle (8) du tube. Un circuit de contrôle (20) commande la valve de déviation et le générateur de gaz en fonction de consignes préréglées, traite les mesures de pression obtenues du capteur de pression, vérifie l'étalonnage du capteur en fonction des mesures et de la différence de hauteur entre les sorties du tube, et génère des données de niveau en fonction des mesures de pression traitées et du coefficient d'étalonage. Une autre valve (28) interposée entre le capteur (14) et le tube (2) et sous contrôle du circuit de contrôle (20), permet de considérer la dérive possible du capteur.
Patent CA-2439842-A1 (CA)
Title: Modulateurs du recepteur gaba pour le traitement de maladies neurodegeneratives de l'oeil
Inventor: REIMER-HEVIA CORNELIA
IPC: A61P27/10
Filed: 2002-02-13
Abstract: L'invention concerne l'utilisation de compositions pharmaceutiques contenant un modulateur du récepteur GABA en ophtalmologie pour la prévention, le prétraitement et/ou le post-traitement de maladies neurodégénératives de l'oeil, les modulateurs du récepteur GABA étant sélectionnés dans le groupe comprenant les benzodiazépines, les ligands au récepteur de benzodiazépine de différentes structures, les bêta-carbolines, les barbiturates, les dérivés d'acide barbiturique et/ou les neurostéroïdes.
Patent CA-2441778-A1 (CA)
Inventor: SMITH IAN EDWARD DAVID
IPC: C07D409/14
Filed: 2002-03-21
Abstract: L'invention concerne de nouveaux dérivés d'aminopiperidine, un procédé d'élaboration correspondant, des compositions pharmaceutiques et l'utilisation de tels composés en médecine. Notamment, les composés de formule (I) empêchent le virus d'immunodéficience humaine (VHI) d'entrer dans des cellules par l'intermédiaire du blocage de l'interaction de la protéine de l'enveloppe virale gp (120) avec un récepteur de chimiokine, à la surface cellulaire. Par conséquent, on peut utiliser de manière avantageuse ces composés en tant qu'agents thérapeutiques dans le traitement de maladies transmises par le virus de l'immunodéficience humaine (VIH), seuls ou combinés avec d'autres inhibiteurs de la réplication virale du VIH ou avec des amplificateurs pharmaceutiques. Cette invention concerne aussi des composés de formule générale (I), dans laquelle R?1¿, R?2¿, R?3¿, X et A sont définis tels que dans le descriptif.
Patent CA-2442344-A1 (CA)
Inventor: GRABLE DAVID
IPC: B60N2/02
Filed: 2003-09-24
Abstract: A seatback recliner mechanism incorporated into a vehicle, the seat including a seat bottom and a pivotally engaged seatback. The recliner mechanism includes a pair of lower supports forming a part of the seat bottom and secured to at least one of first and second sides of the seat bottom. A  first gear is fixed between the lower support and at a generally upper end and a pair of upper supports are pivotally secured to the lower supports and include a second rotatable gear meshingly engaged with the first gear. The seatback includes an upper arm pivotally secured to the upper support in coaxial fashion relative to a third rotatable gear meshingly engaged with the second gear. A first lever is operative to pivot the upper support relative the lower support over a specified range of forward incline and rearward recline. A second lever is operative to pivot the upper arm, relative to the upper support, to a substantially forward and horizontal position. A third lever unseats and rotates an intermediate plate, disposed between the upper and lower support plates and operatively engaged to the upper support plates in the released position, to a predetermined and forwardly inclined position.
Patent CA-2442367-A1 (CA)
Title: Method for detecting multiple dna binding protein and dna interactions in a sample, and devices, systems and kits for practicing the same
Inventor: FANG YU
IPC: C12N1/20
Filed: 2002-03-29
Abstract: Methods for detecting the presence of at least one, usually a plurality of, DNA binding proteins, e.g., transcription factors, in a sample, both qualitatively and quantitatively, are provided. In the subject methods, a substrate having one or more DNA probes immobilized on a surface thereof, one for each DNA binding protein of interest, is contacted with a sample under conditions sufficient for binding complexes of the probes and their respective DNA binding proteins to be produced. The sample may be purified with respect to one or more DNA binding proteins or be a cellular/nuclear extract. Resultant binding complexes on the surface of the substrate are then detected and related to the presence of the DNA binding protein-DAN interations of interest in the sample. Also provided are devices and systems for use in practicing the subject methods. The subject methods find use in a variety of different applications, e.g., detecting the presence of a transcription factor in a sample, the study of transcription factor profiles in response to a given stimulus, screening for therapeutic agents, and the like.
Patent CA-2442398-A1 (CA)
Inventor: MANGANIELLO MARK
IPC: A47J27/04
Filed: 2003-09-24
Abstract: A steam cooker has an insulated housing that surrounds an internal cooking compartment accessible through a door. In one form, a supply of water is held in the compartment and immerses a plate-like resistance heating element mounted at the floor. Water is automatically added to this supply when both 1) a water level sensor indicates a refill, and 2) a door switch signals that the door is open.  These signals together open a normally-closed solenoid valve in a water feed line. A steam outlet located above the maximum water level is in fluid communication with and adjacent another electrically-operated solenoid valve that is normally open to atmosphere. In one mode of operation, a temperature sensor in close physical proximity to the steam outlet and the solenoid valve closes the solenoid wherein the sensed steam temperature is at or above a set level. The outlet steam is also connected to a pair of water column pressure-responsive microswitches that control power to the heating element and, if there is an over-pressure, to open the solenoid valve to vent the steam to atmosphere. Plural such steam cookers can operate in parallel stacked in a single cabinet, and each capable of operating in a fast cook mode where the water and power savings advantages of the electric steam trap are disabled or adjusted.
Patent CA-2443993-A1 (CA)
Title: Methods and reagents for cell transplantation
Inventor: LEE IKE W
IPC: A61K35/12
Filed: 2002-04-12
Abstract: The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells;  (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100%  of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).
Patent CA-2444278-A1 (CA)
Title: Modified cyclosporine which can be used as a pro-drug and use thereof
Inventor: WENGER ROLAND
IPC: A61P27/02
Filed: 2002-04-22
Abstract: The invention relates to a pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue of general formula (1) wherein the carbon atom Ca is one of the links in said undecapeptide cycle; - substituents Y individually represent a hydrogen atom or form a bond together; - substitutents R1 and R3 independently represent a hydrogen atom, an aralkyl group, an alkaryl group, a heteroalkyl group, a heterocyclic group, a heterocyclic alkyl group, an alkyl heterocyclic group or an alkyl group having 1-6 carbon atoms which is linear or branched, and which is optionally substituted by at least one of the groups chosen from among -COOH, -CONHR8, -NHC0=NH(NH2), -NHC=NR8(NH2), -NH2, -NHR8, -NR82, -N+R83, -OH, -OPO(OR8)2, -OPO(OH)(OR8), -OPO(OH)2, -OSO(OR8)2, -OSO(OH)(OR8), -OSO(OH)2, and the different salts produced therefrom, each of the substituents R8 independently representing an alkyl group which is linear or ramified having 1 - 6 carbon atoms; - substituents R2 and R4 independently represent a hydrogen atom, an alkaryl group or an alkyl group having 1 - 6 carbon atoms which is linear or branched; - the substituents R5 and R6 individually represent a hydrogen atom, an aralkyl group, an alkyl group having 1-6 carbon atoms which is linear or branched; and substituent R7 represents an alkaryl group, a heteroalkyl group, a heterocylic group,a heterocylic alkyl group, an alkyl heterocyclic group or an alkyl group having1 - 6 carbon atoms which is linear or branched.
Patent CA-2448337-A1 (CA)
Title: Butyl-type rubber with high viscosity
Inventor: GRONOWSKI ADAM
IPC: C08F2/06
Filed: 2003-11-03
Abstract: The present invention relates to an elastomer having repeating units derived from at least one isomonoolefin monomer, at least one diisoalkenylbenzene monomer, and optionally further copolymerizable monomers, said elastomer having a Mooney viscosity (ML 1+8@125 °C according to ASTM D1646) of more than 80 units, as well as a curable composition comprising said elastomer and a shaped article manufactured from said curable composition.
Patent CA-2448885-A1 (CA)
Inventor: MCARTHY TROY D
IPC: F01L3/08
Filed: 2003-11-10
Abstract: A valve stem seal assembly incorporates a cylindrical retainer having an axis and an upper end about which symmetrically and circumferentially arranged, alternating first and second sets of fingers have radially inwardly depending upper ends. The first set of fingers is generally parallel to the axis and the upper ends are generally perpendicular to the axis to engage a first exterior annular groove of an elastomeric seal body. The first set of fingers provides for axial attachment of the seal body to a top of a valve guide. The second set of fingers is generally arcuate and the upper ends extend radially inwardly to engage a second exterior annular groove of the seal body. The second set of fingers eliminates the need for a garter spring used by traditional valve stem seal assemblies by generating a force to urge the sealing lip against a reciprocating valve stem.
Patent CA-2451063-A1 (CA)
Title: Baler
Inventor: VIAUD JEAN
IPC: A01D90/04
Filed: 2003-11-27
Abstract: A large round baler is equipped with a plurality of components for delivering crop to an inlet of a baling chamber of a large round baler. These components have a width which is substantially wider than the baling chamber inlet and include a crop take-up device and a crop processing arrangement, such as a cutter head, that receives crop from the crop take-up device. The crop processing arrangement delivers the processed crop to a transverse conveyor, which narrows the stream of crop to the width of the baling chamber inlet.
Patent CA-2451982-A1 (CA)
Title: Method and nucleic acids for the analysis of colorectal cell proliferative disorders
Inventor: LESCHE RALF
IPC: C12N15/09
Filed: 2003-02-13
Abstract: The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.
Patent CA-2452131-A1 (CA)
Title: Use of untranslated region of osmotin gene to enhance transgene expression in plants
Inventor: MERLO DONALD JOSEPH
IPC: A01H5/00
Filed: 2004-01-06
Abstract: The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 5' and 3' untranslated regions of genes encoding osmotin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional procedures, resulting in enhanced expression of the selected coding region. In a preferred embodiment, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.
Patent CA-2452701-A1 (CA)
Inventor: CODY MICHAEL
IPC: A01N63/00
Filed: 2003-12-23
Abstract: A method of sustaining plant growth in toxic substrates polluted with heavy metal elements, characterized in that it comprises amendment and remediation of the toxic substrates with a bio-organic-zeolitic mixture. Vegetation, such as hyperaccumulator plants or native plants and grasses for in situ remediation, will now grow, and the mobility of the subsurface contaminants will be inhibited. The method can also be used as a fertilizer and for beneficiation of normal, uncontaminated soils.
Patent CA-2452906-A1 (CA)
Title: Method for maintaining image squareness and image on image registration
Inventor: KERXHALLI DAVID M
IPC: G03G15/00
Filed: 2003-12-10
Abstract: A method for preserving image squareness and image on image registration in a system having a plurality of imaging stations, each imaging station having an ROS. The method includes adjusting the target skew of a reference ROS within one of the plurality of imaging stations by the angular difference between the actual reference ROS position and the target position for the reference ROS and adjusting the target skew of the reference ROS by the skew of the reference ROS relative to the desired skew for image squareness.
Patent CA-2453845-A1 (CA)
Title: Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
Inventor: CALABI LUISELLA
IPC: C07F9/645
Filed: 2002-07-10
Abstract: Compounds of general formula (I):in which: R1 is hydrogen, C1-C2O alkyl, C3- C10 cycloalkyl, C4-C2O cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C2-C10 alkylene group or an ortho disubstituted arylene; R2 is hydrogen, C1-C2O alkyl, C3-C10 cycloalkyl, C4-C 2O cycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact wit h physiological systems; R3, R4 and R5 are hydrogen, C1-C20 alkyl, C3-C10 cycloalkyl, C4-C2O cycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42,43,44,49, and between 57 and 83, and radioisotopes chosen among 203Pb 67Ga 68Ga 72As lllIn 113In 90Y 97Ru 62Cu 64Cu 52Fe 52mMn , 140La 175Yb 153Sm 166Ho 149Pm 177Lu 142Pr 159Gd 2l2Bi 47Sc 149Pm 67Cu, 111 Ag, 199 Au, 161Tb and 51Cr as well as the salts thereof with physiologically compatible bases or acids.
Patent CA-2454188-A1 (CA)
Inventor: CARLSON RICHARD A
IPC: F41H1/02
Filed: 2003-12-23
Abstract: A ballistic vest having a front panel and a rear panel attached to each other by releasable connectors. The front and rear panel each have a ballistic package having a plurality of sheets of ballistic material and a semi-rigid frame structure attached to the layers of the ballistic material. The frame structure has a plurality of members defining openings in the frame structure wherein the frame structure absorbs energy from a projectile entering the sheets of ballistic material.
Patent CA-2455271-A1 (CA)
Title: Use of musk autoantibodies
Inventor: VINCENT ANGELA
IPC: C07K16/28
Filed: 2001-06-15
Abstract: There is disclosed a method for diagnosing neurotransmission or developmental disorders in a mammal comprising the step of detecting in a bodily fluid of said mammal autoantibodies to an epitope of the muscle specific tyrosine kinase (MuSK). One such method comprises a) contacting said bodily fluid with said MuSK or an antigenic determinant thereof; and b) detecting any antibody-antigen complexes formed between said receptor tyrosine kinase or an antigenic fragment thereof and antibodies present in said bodily fluid, wherein the presence of said complexes is indicative of said mammal suffering from said neurotransmission or developmental disorders. Also disclosed are kits for use in the diagnosis of neurotransmission and subsequent developmental disorders.
Patent CA-2455835-A1 (CA)
Title: Tetraxial fabric and machine for its manufacture
Inventor: DINI MAMILIANO
IPC: D03D25/00
Filed: 2002-07-01
Abstract: A tetraxial fabric is obtained using warp yarns (11), weft yarns (12), first bias yarns (13) and second bias yarns (14). The warp yarns (11) alternate to the weft yarns (12) and the first bias yarns (13) are overlaid by the second bias yarns (14), in addition the first bias yarns (13) cross the second bias yarns (14) at the crossover points of the warp yarns (11) with the weft yarns (12). The invention includes also a machine to manufacture the said tetraxial fabric.
Patent CA-2457195-A1 (CA)
Title: Trichromatic dyeing process and dye mixtures used therein
Inventor: GISLER MARKUS
IPC: D06P1/384
Filed: 2002-10-14
Abstract: The present invention relates to a process for the trichromatic dyeing or printing of hydroxy-group-containing or nitrogen-containing organic substrates with dye mixtures and also to such dye mixtures and hydroxy-group-containing or nitrogen-containing organic substrates dyed or printed therewith.
Patent CA-2462699-A1 (CA)
Title: Nuclear reactions produced using rapid temperature changes
Inventor: LIN PING-WHA
IPC: G21B1/00
Filed: 2002-09-26
Abstract: A method of generating a nuclear reaction from gas stream containing water which involves heating a gas stream at a rapid rate sufficient to dissociate the water into hydrogen and oxygen and to transform hydrogen ions into proto ns which produce nuclear reactions, including nuclear fusion. Once the reaction s state is reached, no additional heat needs to be inputted into the reaction system. The resulting nuclear reaction can be used to produce heat for buildings, heat that can be used to generate electricity, and heat that can be used for other purposes.
Patent CA-2462928-A1 (CA)
Inventor: ROY DEBJANI
IPC: C12Q1/6858
Filed: 2002-10-25
Abstract: The invention relates to a method for analysis of methylation models in genomic DNA. In contrast to conventional methods for the analysis of methylation models, said method comprises a two-part method, whereby the genomic DNA is firstly subjected to a methylation specific treatment followed by an isothermal replication step.
Patent CA-2469341-A1 (CA)
Inventor: AITKEN STEVEN
IPC: H01J23/033
Filed: 2002-12-04
Abstract: An electron collector assembly for an electron beam tube comprises an electron collector (2), which is at least partially surrounded by dielectric material, such as a dielectric fluid (5). A heat pipe (6), in communication with the dielectric fluid, is provided. Heat energy from the collector is transferred to the dielectric fluid, and hence to the heat pipe. By pumping coolant through the heat pipe, heat energy is removed from the vicinity of the collector. Previous proposals for cooling electron collectors necessarily involved non-conducting fluids as coolants. The provision of a dielectric fluid as an intermediary between the collector and the heat pipe allows greater freedom in the choice of coolant.
Patent CA-2470845-A1 (CA)
Title: Characterization and measurement of superconducting structures
Inventor: ZAGOSKIN ALEXANDRE M
IPC: G01R33/035
Filed: 2002-12-18
Abstract: A structure comprising a tank circuit inductively coupled to a flux qubit or a phase qubit. In some embodiments, a low temperature preamplifier is in electrical communication with the tank circuit. The tank circuit comprises an effective capacitance and an effective inductance that are in parallel or in series. In some embodiments, the effective inductance comprises a multiple winding coil of wire. A method that includes the steps of (i) providing a tank circuit and a phase qubit that are inductively coupled, (ii) reading out a state of the phase qubit, (iii) applying a flux to the phase qubit that approaches a net zero flux, (iv) increasing a level of flux applied to the phase qubit, and (v) observing a response of the tank circuit in a readout device.
Patent CA-2472506-A1 (CA)
Title: Viscosity index improvers for lubricating oil compositions
Inventor: BRIGGS STUART
IPC: C10N20/04
Filed: 2004-06-25
Abstract: A polymer suitable for use as a viscosity index improver for lubricating oil compositions, which is at least one, at least partially hydrogenated linear or star-shaped random copolymer of isoprene and butadiene, in which at least 70 wt. % of the butadiene is incorporated into the polymer as 1, 4 units and the weight ratio of isoprene addition product to butadiene addition product in the copolymer is in a range of from about 90:10 to about 70:30.