baber/WOPTO huggingface dataset:
Patent JP-2023074705-A (JP)
Title: Work-piece mover and pre-cutter
Inventor: NAKAGAWA KATSUHIDE
IPC: B27C9/00
Filed: 2021-11-18
Abstract: To provide a work-piece mover and a pre-cutter enable a number of work-pieces to be efficiently manufactured and deliverable.SOLUTION: The pre-cutter determines whether one of work-pieces and the other of the work-pieces satisfy a preset replacement condition in a S44 process, as arrangement change control of changing a packing style of packing, and when determining that the materials satisfy the replacement condition, arranges the other of the work-pieces at a predetermined position at which the one of the work-pieces is arranged in a S45 process. This not only enables a loader to stack up the work-pieces in a predetermined alignment order so that the materials can be packed but also enables the loader to stack up the work-pieces in an alignment order different from the predetermined alignment order, depending on situations. This can reduce time elapsing until the work-pieces can be packaged and suppress a space necessary for loading the work-pieces from enlarging, as well as, facilitates a cutter to easily cut the work-pieces in a shortest time.SELECTED DRAWING: Figure 4
Patent JP-2023084611-A (JP)
Title: game machine
Inventor: SUGANO SHOTA
IPC: A63F5/04
Filed: 2021-12-07
Abstract: To provide a game machine which can prevent the generation of a capturing property and prevent the reduction in the merchantability of a game machine.SOLUTION: AT transition winning assistance is the winning assistance which notifies of an operation mode including the correct answer hitting order that enables winning of bell A to bell D in winning area (hitting-order bell 1) to winning area (hitting-order bell 8). The operation mode notified in the AT transition winning assistance does not include the operation mode in which a first stop button is operated first. In a case where the winning area (hitting-order bell 1) to winning area (hitting-order bell 8) are won and the AT transition winning assistance is executed, when the plurality of stop buttons are operated in the operation mode along the AT transition winning assistance, a performance state can transition to the AT state, and when the plurality of stop buttons are operated in the operation mode not along the AT transition winning assistance, the performance state does not transition to the AT state.SELECTED DRAWING: Figure 6
Patent JP-2023085091-A (JP)
Title: tire
Inventor: ONO TAKATOSHI
IPC: B60C19/00
Filed: 2021-12-08
Abstract: To provide a tire capable of suppressing damage to a communication device.SOLUTION: A tire 1 is equipped with a side rubber 8, a bead filler 4b, a carcass 5 that has a carcass ply 5a including a carcass cord 5c, and a communication device 10. The communication device has an RF tag 10e, and a tag coating rubber portion 10f covering the RF tag. The communication device is disposed between the side rubber and the bead filler. The 100% modulus M100 of the side rubber is smaller than the 100% modulus M100 of the tag coating rubber portion, and the 100% modulus M100 of the tag coating rubber portion is smaller than the 100% modulus M100 of a contact bead filler portion contacting with the communication device of the bead filler. A dynamic elastic storage modulus E' of the side rubber is smaller than a dynamic elastic storage modulus E' of the contact bead filler portion.SELECTED DRAWING: Figure 1
Patent JP-2022161808-A (JP)
Title: Reinforcement pipe manufacturing method and reinforcement pipe
Inventor: SUZUKI REIICHI
IPC: B23K9/028
Filed: 2021-12-08
Abstract: To provide a reinforcement pipe manufacturing method capable of manufacturing a highly rigid light reinforcement pipe with high work efficiency, and provide the reinforcement pipe.SOLUTION: This reinforcement pipe manufacturing method comprises: a padded bead forming step of inserting a welding torch 30 from an open end 11 of a pipe 10 into the pipe 10, and forming a padded bead 20 in at least a part of an inner wall surface 12 of the pipe 10 in a peripheral direction through brazing using a solder material or welding using a welding material; a reinforcement plate disposing step of inserting, after the welding torch 30 has been removed from the pipe 10, a reinforcement plate 25 into the pipe 10, and disposing the reinforcement plate 25 so as to contact the padded bead 20; and a reinforcement plate welding step of fillet-welding at least parts of an edge part 26 of the reinforcement plate 25 and the inner wall surface 12 of the pipe 10.SELECTED DRAWING: Figure 1B
Patent JP-2022022420-A (JP)
Title: Diagnostic assays and kits for detection of folate receptor 1
IPC: G01N33/53
Filed: 2021-12-10
Abstract: PROBLEM TO BE SOLVED: To provide diagnostic assays and kits for detection of folate receptor 1. 
     SOLUTION: The invention generally relates to antibodies that bind to human folate receptor 1, and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided. The present invention provides methods for detection of FOLRI in a sample that can be used, for example, to stratify patients. Thus, in one embodiment, the invention provides a method of treating a patient having a folate receptor 1-mediated disease, the method comprising (a) measuring the shed folate receptor 1 (FOLRI) expression level or FOLRI on a circulating tumor cell in a sample taken from a patient. 
     SELECTED DRAWING: None 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023086573-A (JP)
Title: Sputtering apparatus and manufacturing method of substrate with film
Inventor: ISA AKIHIRO
IPC: C23C14/34
Filed: 2021-12-10
Abstract: To provide a sputtering apparatus and a manufacturing method of a substrate with a film capable of suppressing a generation of a particle and depositing a high-quality film for a large-sized substrate requiring multiple target plates arranged adjacent each other, the sputtering apparatus depositing a film of a film deposition material by a magnetron method to a main surface of a substrate transported in a predetermined direction.SOLUTION: A cathode unit 3 is arranged capable of facing a main surface Ga1 of a substrate Ga and includes: multiple plate shaped target plates 31 of which longitudinal direction is orthogonal to a transportation direction of the substrate Ga and which are arranged adjacent each other along the orthogonal direction; multiple magnet units 32 for generating a magnetic field toward an opposite direction of the substrate Ga in the target plate 31; and a backing plate 33 arranged between the target plate 31 and the magnet unit 32, multiple magnet units 32 being arranged in each of a back side of multiple target plates 31.SELECTED DRAWING: Figure 2
Patent JP-2022037096-A (JP)
Title: Information processing apparatus and program
IPC: G06Q50/10
Filed: 2021-12-14
Abstract: PROBLEM TO BE SOLVED: To provide an information processing apparatus and a program which gives privilege to a participant of a game event based on evidence data. 
     SOLUTION: An information processing apparatus (10) capable of communicating with terminal devices (12, 14) includes acquiring means (44) for acquiring, from the terminal devices (12, 14), evidence data indicating that a game vent hosted by a user in a real world is held, and giving means (48) for giving a privilege to a participant of the game event based on the evidence data acquired by the acquiring means (44). 
     SELECTED DRAWING: Figure 3 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023090296-A (JP)
Title: Liquid jet head and liquid jet recording apparatus
Inventor: KOYANO TAKANORI
IPC: B41J2/18
Filed: 2021-12-17
Abstract: To provide a liquid jet head and a liquid jet recording apparatus which can obtain the stable discharge performance.SOLUTION: An ink jet head 5 comprises: a head chip in which a plurality of discharge channels sequentially arrayed in a -X direction from a + X direction of an X direction are provided and which jets ink in the discharge channels; a channel member 44 which has a guide channel 104 that guides ink in the - X direction from the + X direction of the X direction and in which the guide channel 104 is connected to each discharge channel; and a substrate unit on which a plurality of drive ICs 84 arrayed along the X direction are mounted, and which is thermally connected to the channel member 44. The channel member 44 includes a cooling channel 102 which guides ink in the + X direction from the - X direction of the X direction to cool the plurality of drive ICs 84.SELECTED DRAWING: Figure 9
Patent JP-2023090348-A (JP)
Title: Misfire determination device for internal combustion engine
Inventor: KURISAKA ITSUYA
IPC: B60W10/02
Filed: 2021-12-17
Abstract: To provide a misfire determination device for an internal combustion engine capable of suppressing deterioration of misfire determination accuracy.SOLUTION: When rotating speed of a rotating shaft 60a of a motor generator 60 is low, a PU 72 engages a clutch 50 and then, starts combustion control of an internal combustion engine 10 to start the internal combustion engine 10. When the rotating speed of the rotating shaft 60a is high, the PU 72 engages the clutch 50 to apply initial rotation to a crank shaft 28, and then, releases the clutch 50. Then, the PU 72 starts the combustion control of the internal combustion engine 10. Compared to the former start processing, in the latter start processing, the PU 72 increases a delay time from start of the combustion control to start of misfire determination processing.SELECTED DRAWING: Figure 1
Patent JP-2022042514-A (JP)
Title: Compressor
IPC: F04B39/06
Filed: 2021-12-20
Abstract: PROBLEM TO BE SOLVED: To provide a compressor which cools a motor from the inner side while inhibiting deterioration of a cooling medium and inhibits deterioration of motor output and the efficiency. 
     SOLUTION: A compressor 1 includes: a compressor body 2 which compresses a gas; a motor 3 in which a rotor 33 and a stator 34 are housed in a motor chamber 37 of a motor casing 31 and which rotationally drives the compressor body 2; a gas cooler 6 which cools a compressed gas compressed by the compressor body 2; an introduction passage 15 for introducing the compressed gas cooled by the gas cooler 6 into the motor chamber 37; and a return passage 16 for returning the compressed gas, which is introduced into the motor chamber 37 to cool the interior of the motor 3, to the upstream side of the gas cooler 5. 
     SELECTED DRAWING: Figure 1 
     COPYRIGHT: (C)2022,JPO&INPIT
Patent JP-2023091664-A (JP)
Title: Game program, information processor, information processing method, and information processing system
Inventor: KOSUGI KANAME
IPC: A63F13/45
Filed: 2021-12-20
Abstract: To allow a user to maintain motivation to send a good sleeping habit.SOLUTION: A game program executes: an acquisition step of acquiring a user's sleep information; a determination step of determining game parameters on the basis of a user's selection operation; an event step of generating an event regarding a user on the basis of the user's sleep information acquired in the acquisition step and the game parameters determined in the determination step; and a presentation step of presenting first sleep information of a first user and first presentation information regarding a first event occurring based on game parameters of the first user in the event step. In the presentation step, the first presentation information presented to a second user includes the first sleep information of the first user, information based on event contents of the first event, and game parameters of the first user as information for generating the first event.SELECTED DRAWING: Figure 1
Patent JP-2023092148-A (JP)
Title: Heat exchange type ventilation device
Inventor: IZUKAWA SEIJI
IPC: F24F7/08
Filed: 2021-12-21
Abstract: To obtain a heat exchange type ventilation device which enables improvement of workability during maintenance.SOLUTION: A heat exchange type ventilation device 1 includes: a box-shaped housing 4 provided with a supply air channel for supplying air from an outdoor space to an indoor space and an exhaust air channel for exhausting air from the indoor space to the outdoor space; a supply air blower disposed in the supply air channel; an exhaust air blower disposed in the exhaust air channel; a heat exchange element 8 which is disposed within the housing 4 and conducts heat exchange between air flowing in the supply air channel and air flowing in the exhaust air channel; and a drain pan 10 which is disposed below the heat exchange element 8 and receives drain water flowing down from the heat exchange element 8. The heat exchange element 8 and the drain pan 10 are connected to each other.SELECTED DRAWING: Figure 3
Patent JP-2023092373-A (JP)
Title: Heat transfer suppression sheet and battery pack
Inventor: ONAYA NAOKI
IPC: H01M50/293
Filed: 2021-12-21
Abstract: To provide: a heat transfer suppression sheet capable of maintaining the shape thereof even in cases where the heat transfer suppression sheet is exposed to high temperatures, thereby being capable of suppressing a decrease in the heat insulation performance; and a battery pack which comprises the heat transfer suppression sheet.SOLUTION: A heat transfer suppression sheet 10 contains: first organic fibers 1 that do not have a glass transition temperature at a temperature lower than 120°C; first inorganic particles 2; and a resin binder 9. The first organic fibers 1 have a melting point Tm at a temperature equal to or higher than 200°C. Preferably, the elastic modulus of the first organic fibers 1 at Tm°C is 0.1% or more of the elastic modulus of the first organic fibers 1 at 23°C.SELECTED DRAWING: Figure 1
Patent JP-2023094138-A (JP)
Title: Wind turbine power generation device
Inventor: ASAI SOICHIRO
IPC: F03D7/04
Filed: 2021-12-23
Abstract: To provide a wind turbine power generation device in which a wind turbine generator exhibits a yaw function to face a wind direction in all directions, so that rotation efficiency of a wind turbine and a generator is improved to increase generated power.SOLUTION: A wind turbine power generation device comprises a rotary disc 1, and a wind turbine generator 5 comprising a wind turbine 2, a generator 3 and a wind collector 4, and supports the wind turbine generator 5 with a wind inflow port 10 of the wind collector 4 directed toward a center C of the rotary disc 1 at a point away from the center C of the rotary disc 1.SELECTED DRAWING: Figure 1
Patent JP-2023094312-A (JP)
Title: Pants-type diaper
Inventor: IKEUCHI MASATOSHI
IPC: A61F13/534
Filed: 2021-12-23
Abstract: To provide a pants-type diaper in which male genitalia is less likely to get caught in an interior component when worn by a man.SOLUTION: A pants-type diaper 1 includes an exterior sheet 10 and an interior member 20. The interior member 20 includes an absorbent body 21, a back sheet 22, a center sheet 23, and side sheets 24. Width direction edge of the back sheets are folded back to the skin side of the absorbent material to form a back-sheet folded portion 22a. The side sheets have a first portion 25a and a second portion 25b with the outside of the side sheet folded back in the width direction, and the outer edge of the first portion has an outer edge joining region 31 that joins the first portion and the back-sheet folded portion. At the front abdomen side edge of the side sheet, there is a non-bonded area 40 where the first portion and the back sheet folded portion are not bonded.SELECTED DRAWING: Figure 2
Patent JP-2023096310-A (JP)
Title: Handcart
Inventor: SHIMA YOSHIHIRO
IPC: B62B5/00
Filed: 2021-12-27
Abstract: To provide a handcart that makes it possible to readily attach an opening edge of a storage bag and has an excellent appearance because the storage bag can be attached without making the storage bag bulky and causing a sag in an internal part of the opening edge due to a difference between outer and inner diameters.SOLUTION: A seat frame 21 that supports a seat part of a handcart 1 capable of being seated includes left and right side frame pieces 212 extending in a fore-and-aft direction and being borne by respective front wheel leg frames 13, and front and rear side frame pieces 213 and 214 extending in a horizontal direction and being coupled to front and rear ends of the left and right side frame pieces 212. Both ends of a bar material 24 whose cross-sectional shape is smaller than those of the left and right side frame pieces 212 and front side frame piece 213 and which is disposed along the lower sides of the left and right side frame pieces 212 and front side frame piece 213 out of the frame pieces 212 to 214 are attached to the seat frame 21. An opening edge of a storage bag 42 that opens upward is attached to the bar material 24.SELECTED DRAWING: Figure 6
Patent JP-2023069985-A (JP)
Title: Sleeping mat comprising rapid air charge/air exhaust nozzle
Inventor: HUANG XIUYA
IPC: A47G9/10
Filed: 2021-12-27
Abstract: To provide a sleeping mat comprising a rapid air charge/air exhaust nozzle including a sleeping mat including a nozzle.SOLUTION: A nozzle comprises: a base: an air charge/air exhaust path; and a sealing lid. The sealing lid is detachably fitted to the air charge/air exhaust path so as to seal the path. The air charge/air exhaust path is detachably fitted to the base so as to seal the base. An air exhaust spacer is provided on a top of an internal bracket of the air charge/air exhaust path, and an air charge spacer is provided on a bottom of the internal bracket. By installing a three-stage nozzle configuration, the air charge/air exhaust path and the base are more tightly fitted, for achieving greater sealing property relative to prior nozzles. By switching positions of first and second barriers of a switching barrier in a use step, an air charge mode and an air exhaust mode can be switched. By switching the mode, the sleeping mat of the invention can achieve a function of a rapid air charge/air exhaust.SELECTED DRAWING: Figure 1
Patent JP-2023098523-A (JP)
Title: Active oxygen feed device, treatment device by active oxygen and treatment method by active oxygen
Inventor: FURUKAWA TAKUMI
IPC: A61L2/20
Filed: 2021-12-28
Abstract: To provide an active oxygen feed device capable of more stably applying a treatment by active oxygen onto a surface of a treatment target.SOLUTION: An active oxygen feed device includes: a housing having an opening; and a plasma actuator and an ozone degradation device therein. The plasma actuator includes a first electrode, a dielectric body and a second electrode laminated in this order, and is configured to, by applying a voltage, blow out an induced flow containing ozone in a first direction being one direction along a surface of the dielectric body from the first electrode. The ozone degradation device is configured to degrade the ozone to generate active oxygen in the induced flow. The plasma actuator and the ozone degradation device are arranged so that the induced flow containing the active oxygen flows out from the opening to an outside of the housing. An edge part at a second direction side being an opposite direction of the first direction of the second electrode includes a projection part extending in the second direction, and overlaps the first electrode only at the projection part, and the projection part has a constant width in the second direction.SELECTED DRAWING: Figure 1
Patent JP-2021530392-A (JP)
Title: ねじ山付きマスターピン付きリンクアセンブリー
IPC: B62D55/084
Filed: 2019-06-24
Abstract: 作業機械のリンクアセンブリーとともに使用するためのマスターリンクボックスが開示される。マスターリンクボックスは、第一および第二のねじ山付きピンボアおよび第一および第二のねじ山付き通路を有する第一および第二のマスターリンクと、遠位部分に沿った外周表面上にねじ山を有するマスターリンクピンと、第一および第二の締結具とを含み得る。マスターリンクピンは、第一または第二のピンボアのうちの一つを通してマスターリンクボックスに挿入され得る。締結具は、第一の締結具がマスターリンクピンの近位部分に当接し、第二の締結具がマスターリンクピンの遠位部分に当接するように、ねじ山付き通路に固定され得る。【選択図】図１０
Patent JP-2021522332-A (JP)
Title: テネリグリプチン臭化水素酸塩アモルファス及びその調製方法
IPC: A61K31/496
Filed: 2018-04-25
Abstract: １種のテネリグリプチン２．５臭化水素酸塩のアモルファス及びその調製方法を提供する。前記方法は、テネリグリプチン２．５臭化水素酸塩水和物を利用して、一定の水浴温度下でロータリーエバポレーターにより回転蒸発を行う、又はテネリグリプチン２．５臭化水素酸塩水和物を溶媒中に溶解し、次に、スプレードライヤーを利用して溶液に対して噴霧乾燥を行う、又は、テネリグリプチン２．５臭化水素酸塩水和物の溶液を凍結乾燥させることで、テネリグリプチン２．５臭化水素酸塩のアモルファスを調製することを含む。前記方法は、シンプルであり、効率が高く、経済的であり、中間体の品質が制御可能であり、工業的調製に適しており、調製して得た製剤製品が安定的である。
Patent JP-2021522338-A (JP)
Title: 強力なチアゾール化合物の調製方法、医薬製剤およびその使用
IPC: A61K47/38
Filed: 2019-04-26
Abstract: 本発明は、Ｎ−［２−［２−（４−クロロフェニル）−４−チアゾリル］エチル］−ブタンアミドを調製する工程に関する。本発明はさらに、皮膚免疫疾患、皮膚自己免疫疾患および色素沈着障害を伴う疾患の治療および予防のための活性化合物としてのＮ−［２−［２−（４−クロロフェニル）−４−チアゾリル］エチル］−ブタンアミド、または、その薬学的に許容される塩からなる医薬製剤および前記医薬製剤の使用に関する。
Patent JP-2021536442-A (JP)
Title: Ｃ−ｃケモカイン受容体４（ｃｃｒ４）拮抗薬および１種以上のチェックポイント阻害剤を用いる併用療法
IPC: A61K39/395
Filed: 2019-08-28
Abstract: 本開示は、癌の治療でのＣ−Ｃケモカイン受容体４（ＣＣＲ４）拮抗薬および１種以上の免疫チェックポイント阻害剤の併用療法を対象とする。
Patent JP-2021536210-A (JP)
Title: 自動車を作動させる方法、制御装置、自動車
IPC: B60L15/20
Filed: 2019-08-01
Abstract: 【課題】本発明は、電気式の駆動機械を備えた駆動機構と、摩擦ブレーキシステムと、調節部材とを有する自動車を作動させる方法に関する。【解決手段】調節部材は第１の最終状態と第２の最終状態との間で特に無段階に変位可能であり、第１の最終状態のときの調節部材の位置は０％のパーセント値に相当し、第２の最終状態のときの調節部材の位置は１００％のパーセント値に相当する。調節部材の位置が設定された閾値よりも高いパーセント値を有するときに自動車の加速トルクが設定され、調節部材の位置が閾値よりも低いパーセント値を有するときに自動車の減速トルクが設定される。摩擦ブレーキシステムが制御され、それにより摩擦ブレーキシステムが設定された減速トルクを少なくとも割合に応じて、特に全面的に生成することが意図される。【選択図】  図２
Patent JP-2021534899-A (JP)
Title: 光電子能動植込み型医療デバイス（ａｉｍｄ）のための光ファイバコネクタ
IPC: G02B6/42
Filed: 2018-08-31
Abstract: 本発明は、生体内に植え込むための光電子能動植込み型医療デバイス（ＡＩＭＤ）のための光ファイバコネクタであって、光ファイバの第１組に結合された雄構成要素（Ｍ）と、光ファイバの第２組又は光学素子に結合された雌構成要素（Ｆ）と、雄構成要素及び雌構成要素を結合位置で可逆的に係止するための結合構成要素（Ｃ）と含み、光ファイバの第１組は、光ファイバの第２組又は光学素子と完全に位置合せされ、−  結合構成要素は、固定要素（４０ｆ）と、固定要素（４０ｆ）に対して第１長手方向軸Ｚ１及び／又は第２長手方向軸Ｚ２を中心に回転可能な回転可能要素（４０ｒ）とを含み、コネクタのすべての光ファイバ（４１ｆ）及び光学素子は、回転可能要素の回転時に静止したままであり、−  雄構成要素及び雌構成要素を結合位置で可逆的に係止することは、固定要素に対して回転可能要素を回転させることによって達成され、−  結合構成要素のすべての要素は、雄構成要素及び／又は雌構成要素に取り付けられ、−  雄構成要素及びそれに取り付けられた結合構成要素の任意の要素は、１５ｍｍ以下、好ましくは１０ｍｍ以下、より好ましくは７ｍｍ以下の直径を有する円に内接する、第２長手方向軸Ｚ２に対して垂直な寸法を有する、光ファイバコネクタに関する。【選択図】図１Ｃ
Patent JP-2022501514-A (JP)
Title: 金属基板上に無機粒子を堆積させるための低温法及びこの低温法によって製造される物品
IPC: C23C16/34
Filed: 2019-09-20
Abstract: 化学蒸着（ＣＶＤ）によって、炭窒化チタンを含む無機粒子を金属基板上に堆積させる方法。いくつかの実施形態では、ＣＶＤプロセスには、反応して上記無機粒子を形成する２つ以上の原料ガスを供給してよい。上記原料ガスのうちの少なくとも１つは、チタン原料ガスを含む。また、炭素及び窒素のソースは：（ａ）６５．９キロジュール／モル未満の生成熱エネルギを有する、炭素及び窒素原料ガスを含む単一の原料ガス；並びに／又は（ｂ）炭素‐窒素単結合を有する気体分子を含む炭素原料ガス、及び窒素原料ガスを含む、２つの原料ガスであってよい。いくつかの実施形態では、上記ＣＶＤプロセスには、上記無機粒子を形成するための有機金属化合物を供給してよい。いくつかの実施形態では、上記ＣＶＤプロセスには、アルミニウム含有有機金属還元剤を供給してよい。
Patent JP-2022503928-A (JP)
Title: カテーテル位置合わせ装置及び方法
IPC: A61M25/00
Filed: 2019-10-08
Abstract: 第１の血管から第２の血管を標的化するための発射カテーテルは、近位部分と、針開口及び平坦な長方形の放射線不透過性マーカーを含む遠位部分とを含むカテーテルを含む。平坦な長方形の放射線不透過性マーカーは、回転時に蛍光透視法下で消え、発射カテーテルの回転アライメントに関する情報を提供する。発射カテーテルは、針開口を通って延出するように構成された針を含む。カテーテルを位置合わせする方法は、マーカーが蛍光透視法下で厚さ（例えば、最小の厚さ）を有するまで、第１の血管内でカテーテルを回転させることを含む。厚さは、カテーテルの回転位置合わせを示す。 
【選択図】図４２Ｂ
Patent JP-2022504204-A (JP)
Title: 老化細胞死誘導薬としてのアジスロマイシンおよびロキシスロマイシン誘導体
IPC: A61P25/16
Filed: 2019-10-02
Abstract: 本開示は、老化細胞死誘導薬としての、誘導体を含むアジスロマイシン、ロキシスロマイシン、およびテリスロマイシンの使用を記載する。ヒト線維芽細胞株モデルにおいて老化を誘導するためにＢｒｄＵを使用した。また、化合物を老化細胞死誘導活性に関してスクリーニングするための方法も開示される。タンパク質含量を介して細胞生存率を測定するためにＳＲＢアッセイを使用した。臨床承認薬アジスロマイシン、ロキシスロマイシン、およびテリスロマイシンは、老化細胞死誘導薬であることが判明した。しかしながら、近縁の親化合物であるエリスロマイシンは、老化細胞死誘導活性を示さなかった。アジスロマイシンはヒト線維芽細胞において好気性解糖および自食の両方を強く誘導したが、５０μＭで阻害活性および１００μＭで刺激活性を示すミトコンドリア酸素消費速度を含む二相効果を示した。ｘＣＥＬＬｉｇｅｎｃｅリアルタイムアッセイ系は、アジスロマイシンは老化細胞を優先的に標的とし、およそ９７％を除去する（老化細胞をほぼ２５分の１とする）ことを示した。
Patent JP-2022504673-A (JP)
Title: 加熱可能なガラスパネル
IPC: B60S1/02
Filed: 2019-10-03
Abstract: 本発明は、（ｉ）少なくとも１種のポリマーを含む中間層を介して互いに積層された、内面及び外面をそれぞれ備える第１の外側基材及び第２の内側基材（１）、（ｉｉ）外側基材と内側基材との間に設けられた少なくとも１つの加熱可能な導電層を含むコーティング（２）であって、前記コーティング（２）は、少なくとも１つの加熱可能なコーティングゾーン（３１）と少なくとも１つの非加熱可能なコーティングゾーン（４２、４３）とに分割され、第１の加熱可能なゾーン（３１）は、コーティング削除領域によって絶縁されている少なくとも２つのゾーン境界（６、７）によって区切られる、コーティング、（ｉｉｉ）少なくとも第１及び第２の導電性バスバー（２１、２２）であって、離間した前記第１及び第２のバスバー（２１、２２）のそれぞれは、少なくとも１つの電気的に加熱可能なコーティングゾーン（３１）を横切って電圧を供給するように適合される、第１及び第２のバスバーを含む、積層された電気的に加熱可能なガラスパネルに関する。本発明によれば、電流が前記第１及び第２のバスバー（２１、２２）を通して流されるとき、少なくとも１つの電気的に加熱可能なコーティングゾーン（３１）のみが加熱され、且つバスバー（２１、２２）間に導電路が規定される。 
【選択図】図１
Patent JP-2022505154-A (JP)
Title: 生体内画像ストリームの精査用情報を生成及び表示するためのシステム並びに方法
IPC: A61B1/045
Filed: 2019-10-19
Abstract: システム及び方法は、嚥下式カプセルが生体内で収集した患者の消化管のいくつかの選択された画像を表示及び／又はこれらの画像の分析を提供してもよい。画像は、（例えば、精査用情報として）レビューする、かつ／又はユーザが更に分析するために表示されてもよい。画像ストリームを表し、第１の選択方法に従って自動的に選択された画像部分集合を表示してもよい。ユーザ入力時には、現在表示されている画像に対応する追加画像が表示されてもよく、この追加画像は、第２の選択方法に従って自動的に選択される。第２の選択方法は、生体内画像ストリームの画像と現在表示されている画像との間の関係に基づいてもよい。