baber/WOPTO huggingface dataset:
Patent IL-153876-A0 (IL)
Title: Methods for increasing the production of ethanol from microbial fermentation
IPC: C12R1/02
Filed: 2001-07-23
Abstract: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor by reducing the redox potential, or increasing the NAD(P)H TO NAD(P) ratio, in the fermentation broth after the bacteria achieves a steady state and stable cell concentration in the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity of greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1.
Patent IL-159849-A0 (IL)
Title: Use of atazanavir in hiv therapy
IPC: A61P3/06
Filed: 2002-08-21
Abstract: A method for reducing elevated plasma LDL and/or triglyceride levels in an HIV-infected patient is disclosed. In this method, atazanavir (BMS-232632) can be used to treat HIV infection in patients exhibiting elevated plasma LDL-cholesterol and/or triglyceride levels, can be substituted for an offending HIV protease inhibitor used in such therapy, or can be used in combination with an HIV protease inhibitor metabolized by cytochrome P450 monooxygenase.
Patent IL-162525-A0 (IL)
Title: Detection of odours using insects
IPC: G01N33/00
Filed: 2002-12-20
Abstract: Apparatus for detecting a specific target odour comprises: a detector unit adapted to have removably associated therewith a holding unit for housing at least one insect in a predetermined position; means for exposing an insect in a holding unit associated with the detector unit to a sample of gas to be tested; and means for enabling monitoring of a response of the insect to the sample thereby to detect a response indicative of the target odour. In use of the apparatus, a holding unit housing at lest one insect that responds in a detectable manner to the target odour is associated with the detector unit. A sample of gas to be tested is supplied to the apparatus, for exposure to the insect or insects in the holding unit. The insect is monitored for a response indicative of the target odour, thus enabling determination as to whether or not the target odour is present in the sample. Because the holding unit is not part of the detector unit but is removably associated with therewith, the holding unit can be used to transport an insect or insects housed therein from a first, remote location, e.g. where insects are raised and conditioned, to a point of use at a second location where the detector unit is located. The detector unit may be a permanent or semi-permanent fixture at a point of use, or may be in the form of a portable unit. Also disclosed is a method of detecting a specific target odour.
Patent IL-176182-A0 (IL)
Title: Control apparatus for use with a computer or video game
IPC: A63F/
Filed: 2006-06-07
Abstract: A control device for controlling a display of a computer system for use with a video game includes a coordinate control unit for providing information related to a vertical and horizontal tilt of the control device, a mouse control unit for inputting conventional mouse input information, a game control unit for inputting game control information and a controller for processing the information provided by the coordinate control unit, mouse control unit and game control unit. The vertical and horizontal point of view of the user in the video game and/or the vertical and horizontal position of a cursor on the display is determined based on the information related to the vertical and horizontal tilt of the control device. The control device is preferably shaped like a firearm to enhance the realism of the video game, but may be shaped like a conventional game pad.
Patent IL-180171-A0 (IL)
Title: Novel 2-substituted d-homo-estra-1,3,5(10)-trienes as inhibitors of 17??- hydroxysteroid dehydrogenase type 1
Filed: 2006-12-19
Abstract: The invention relates to novel 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) wherein R<SUP>2</SUP> represents a C<SUB>1</SUB>-C<SUB>8</SUB> alkyl, a C<SUB>1</SUB>-C<SUB>8</SUB> alkyloxy group or a halogen atom, R<SUP>13</SUP> represents a hydrogen atom or a methyl group, and R<SUP>17</SUP> represents a hydrogen atom or a fluorine atom. The invention also relates to the pharmaceutically acceptable salts of said compounds, to the production thereof, and to the use of the same as medicaments for the prophylaxis and treatment of oestrogen-dependent diseases that can be influenced by the inhibition of 17ß-hydroxysteroid dehydrogenase type 1.
Patent IL-182517-A0 (IL)
Title: System and method for production of antibodies in plant cell culture
Filed: 2007-04-12
Abstract: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.
Patent IL-191580-A0 (IL)
Title: Indole derivatives and their use as intermediates in the preparation of quinazoline derivatives
IPC: C07D471/04
Filed: 2008-05-20
Abstract: The invention relates to the use of compounds of the formula I:   
wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, -NH-, -S-, -CH 2 - or a direct bond; n is 0-5; m is 0-3; R 2  represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylsulphanyl, -NR 3 R 4  (wherein R 3  and R 4 , which may be the same or different, each represents hydrogen or C 1-3 alkyl), or R 5 X 1 - (wherein X 1  and R 5  are as defined herein; R 1  represents hydrogen, oxo, halogeno, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 alkoxymethyl, C 1-4 alkanoyl, C 1-4 haloalkyl, cyano, amino, C 2-5 alkenyl, C 2-5 alkynyl, C 1-3 alkanoyloxy, nitro, C 1-4 alkanoylamino, C 1-4 alkoxycarbonyl, C 1-4 alkylsulphanyl, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, carbamoyl,  N- C 1-4 alkylcarbamoyl,  N , N -di(C 1-4 alkyl)carbamoyl, aminosulphonyl,  N -C 1-4 alkylaminosulphonyl,  N , N -di(C 1-4 alkyl)ammosulphonyl,  N -(C 1-4 alkylsulphonyl)amino,  N- (C 1-4 alkylsulphonyl)- N -(C 1-4 alkyl)amino,  N , N -di(C 1-4 alkylsulphonyl)amino, a C 3-7 alkylene chain joined to two ring C carbon atoms, C 1-4 alkanoylaminoC 1-4 alkyl, carboxy or a group R 56 X 10  (wherein X 10  and R 56  are as defined herein); and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
Patent RO-128918-A0 (RO)
Title: Method for synthesis of pure materials by laser ablation in direct flux from multiple non-parallel targets
Inventor: LUCULESCU ROMEO CATALIN
IPC: B01J19/08
Filed: 2012-12-04
Abstract: The invention relates to a method of synthesis of pure materials by laser ablation, in direct flux, from multiple non-parallel targets, intended to be used in electronic industry for thin film deposition and for the synthesis of nanometric materials. According to the invention, the method comprises the simultaneous laser ablation of a plurality of non-parallel targets, the confining of the ablation plasmas in a direction which differs from the initial direction and passing the resulting ablation plasma or the precursors thereof through an adjustable aperture(s) trap.
Patent RO-129855-A0 (RO)
Title: System for remote processing of prescriptions and/or other pharmaceutical services
Inventor: WENCZ OVIDIU
IPC: H04M11/00
Filed: 2014-04-17
Abstract: The invention relates to a system for remote processing of prescriptions and/or other pharmaceutical services to be generally employed in the quick delivery of medical prescriptions to remote clients, through communication networks. According to the invention, the system is characterized in that it comprises a central server (2) as an intermediary and coordinator which can offer one or several of the following functions: receiving a medical prescription from a medical service supplier (3) and/or from a patient (4) and, in case it is able to identify one or several medicaments or products therefor, computing a current address of the patient (4) at the moment of receiving the medical prescription, based on the global positioning system (GPS) associated to a patient's mobile phone; determining and delivering the minimal cost, information for the patient about the closest real pharmacies (5) which can deliver the medical prescription and ordering the distribution of the requested medicaments or products for the patient (4); receiving from the patient (4) a selection of one or several real pharmacies (5) to deliver the medical prescription; and/or coordinating, by means of a financial processor (7) and an insurer (8), one or several financial transactions associated to the delivery of the medical prescription; and in that the delivery of the medicaments/products from the real pharmacy (5) selected by the patient (4) is made using some delivery boxes (9) located at the premises of the real pharmacies (5), which can be opened by scanning the bar code of the electronic prescription and the order confirmation by a pharmacy computer (5.1).
Patent AP-2000001882-A0 (AP)
Title: Cosmetic or dermatological use of 7-hydroxylated steroids alone and /or in combination with elastin derived peptides.
Inventor: MITTS THOMAS F
IPC: A61K31/565
Filed: 1999-11-19
Abstract: The present invention is directed to a composition for improving tissue texture, wherein the composition includes an elastin peptide which is synthesized by selectively cleaving elastin using thermolysin. The composition further provides the incorporation of a 7-hydroxylated steroid. The composition is capable of modifying the physical characteristics of mammalian tissue to which it is applied thus increasing elasticity.
Patent AP-2001002035-A0 (AP)
Title: Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions.
Inventor: BOCAN THOMAS MICHAEL ANDREW
IPC: C07D243/10
Filed: 1999-06-18
Abstract: This invention is the coadministration of acat and mmp inhibitors for the reduction of both the macrophage and smooth muscle cell component of atherosclerotic lesions, thus impairing the expansion of existing lesions and the development of new lesions and for the prevention of plaque rupture and the promotion of lesion regresion in a mammal.
Patent AP-2001002249-A0 (AP)
Title: Process for making N-ARYL-ANTHRANILIC acids and their derivatives.
Inventor: CHEN MICHAEL HUAI GU
IPC: C07C255/62
Filed: 2001-07-20
Abstract: The present invention relates to a process for the preparation of N-arylanthranilic acids, and a process for the preparation of N-aryl anthranilic esters, amides, and hydroxamic esters.
Patent MA-18778-A1 (MA)
IPC: C01B25/235
Filed: 1980-03-18
Abstract: The invention relates to a process for freeing aqueous phosphoric acid solutions from organic contaminants. To this end, the solutions are admixed and reacted with hydrogen peroxide in the presence of a catalyst consisting of a noble metal or metal oxide being inert with respect to phosphoric acid or of a mixture of said noble metal and metal oxide.
Patent MA-21327-A1 (MA)
Inventor: KAREL JOANNES VAN LOON
IPC: A61K31/505
Filed: 1988-07-15
Abstract: Novel N-(3-hydroxy-4-piperidinyl)substituted benzamides of formula   <CHEM>  wherein: R<1> is hydrogen, C1-6alkyl, arylC1-6alkyl, C1-6alkylcarbonyl, aminoC1-6alkyl or mono- and di(C1-6alkyl)aminoC1-6alkyl;  R<2> is hydrogen or C1-6alkyl; R<3>, R<4> and R<5> each independently are hydrogen, C1-6alkyl, C1-6alkyloxy, halo, hydroxy, cyano, nitro, amino, mono- and di(C1-6alkyl)amino, aminocarbonyl, arylcarbonylamino, C1-6alkylcarbonylamino, C1-6alkylcarbonyl, C1-6alkylcarbonyloxy, aminosulfonyl, C1-6alkylaminosulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkylthio, mercapto, trifluoromethyl, arylC1-6alkyloxy or aryloxy;  Alk is a C1-6alkanediy;  X is O, S, NR<6> C(=O) or C(=S); Het is a five- or six membered heterocyclic ring being optionally fused with a six membered carbocyclic ring, and being optionally substituted; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are gastrointestinal motility stimulating agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
Patent MA-25660-A1 (MA)
Inventor: PATRICK COGNOT
IPC: C06B45/02
Filed: 2002-09-23
Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes ( 1 ) are mainly characterized in that they function with a pyrotechnic charge ( 6 ) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston ( 3 ), a very high speed to the active principle ( 4 ), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle ( 4 ) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid ( 4 ).
Patent MA-27390-A1 (MA)
Title: Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
Inventor: ABOUABDELLAH AHMED
IPC: A61P31/04
Filed: 2005-02-28
Abstract: Composé répondant à la Formule générale (I): dans laquelle Ri représente un groupe phényle ou naphtalènyle éventuellement substitué par un ou plusieurs atomes d'halogène ou groupes hydroxy, cyano, nitro, C1-3-alkyle, C1-3-alcoxy, trifluorométhyle, trifluorométhoxy, benzyloxy, C3-6-cycloalkyl-0- ou C3.6-cycloalkylC1-3-alcoxy; R2 représente soit un groupe de formule générale CHR3CONHR4 dans laquelle R3 représente un atome d'hydrogène ou un groupe méthyle et R4 représente un atome d'hydrogène ou un groupe C1-3-alkyle, C3-5-cycloalkyle ou (pyridin-4-yl)méthyle; soit un groupe 2,2,2-trifluoroéthyle; soit un groupe (imidazol-2-yl)méthyle; soit un groupe (benzimidazol-2-yl)méthyle; soit un groupe phényle éventuellement substitué par un ou plusieurs atomes d'halogène ou groupes cyano, nitro, C1-3-alkyle, C1_3-alcoxy, trifluorométhyle ou trifluorométhoxy; et n représente un nombre allant de 1 à 3; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat. Application en thérapeutique.
Patent MA-38864-A1 (MA)
Title: Polypeptides cycliques pour le traitement de l'insuffisance cardiaque
Inventor: ZHAO HONGJUAN
IPC: C07K14/47
Filed: 2014-07-21
Abstract: L'invention concerne un polypeptide cyclique représenté par la formule i': i, ou un amide, un ester ou un sel de celui-ci, ou un bioconjugué de ce polypeptide, x1, x3, x4, x7, x8, x9, x10, x11, x12 et x13 étant définis dans la description. Ces polypeptides constituent des agonistes du récepteur apj. L'invention se réfère également à un procédé de fabrication des polypeptides de l'invention ou de leurs bioconjugués, ainsi qu'à des utilisations thérapeutiques, telles que le traitement ou la prévention de l'insuffisance cardiaque aiguë décompensée (adhf), l'insuffisance cardiaque chronique, l'hypertension pulmonaire, la fibrillation auriculaire, le syndrome de brugada, la tachycardie ventriculaire, l'athérosclérose, l'hypertension, la resténose, les maladies cardiovasculaires ischémiques, la cardiomyopathie, la fibrose cardiaque, l'arythmie, la rétention d'eau, le diabète (y compris le diabète gestationnel), l'obésité, la maladie artérielle périphérique, les accidents cérébrovasculaires, les attaques ischémiques transitoires, les lésions cérébrales traumatiques, la sclérose latérale amyotrophique, les brûlures (y compris le coup de soleil) et la prééclampsie. La présente invention concerne en outre une combinaison d'agents pharmacologiquement actifs et une composition pharmaceutique.
Patent MA-44911-A1 (MA)
Title: Dispositif de mesure des paramètres respiratoires d'un patient
Inventor: MALHOTRA VIDUR
IPC: G01F1/40
Filed: 2017-09-02
Abstract: La présente invention concerne un dispositif de mesure des paramètres respiratoires d'un patient. Dans un mode de réalisation, le dispositif 100 comprend un tube d'écoulement 101 et un corps 102. Le tube d'écoulement 101 est un tube creux comprenant : une première extrémité 103, une seconde extrémité 104 et au moins une partie de tube 105 (représentée par des lignes pointillées), la partie tube ayant une construction géométrique capable de modifier la vitesse/la direction du flux d'air traversant le tube
Patent UY-24389-A1 (UY)
Title: Composición farmacéutica para el tratamiento de carcinoma de epitelio plano
Inventor: SPROLL MARLIES
IPC: A61K39/395
Filed: 1996-12-03
Abstract: La invención se refiere al empleo de una molécula de anticuerpo que se une específicamente a la secuencia de aminoácidos WFGNRWHEGYR del exón variable v6 del gen CD44, para la producción de una composición farmacéutica para la terapia de carcinomas del epitelio plano. En particular, se caracteriza porque la molécula de anticuerpo es el anticuerpo monoclonal BIWA-1 (VFF-18) que se forma por la línea de células hibridomas con el número de depósito DSM ACC2174, o un derivado de este anticuerpo.
Patent UY-26110-A1 (UY)
Title: Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica
Inventor: GAUITER CLAUDIE
IPC: A61P9/12
Filed: 2000-04-18
Abstract: Compuestos de fórmula general (I) (representada en la figura 1), así como procedimientos de preparación de los mismos, caracterizados porque: R1 y R2 representan, independientemente entre sí, un átomo de hidrógeno o un grupo alquilo de 1 a 3 átomos de carbono; R3 representa un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono; W representa un grupo OR4; y R4 representa un grupo alquilo de 1 a 10 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, C3-6 cicloalquilo-C1-3alquilo-, bencilo, o fluoroalquilo de 1 a 6 átomos de carbono. Ejemplos de compuestos de fórmula general (I): -4-[[[2-(1-etilpropoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-n-propilbutoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-metoxi)-3,4-dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; entre otros. Los compuestos de fórmula (I) son de utilidad para la preparación de un medicamento destinado a tratar una patología donde la inhibición de la fosfodiesterasa 5 aporta un beneficio terapéutico, y más particularmente donde la patología consiste en: hipertrofia benigna de próstata, incontinencia, vesícula obstruida, dismenorrea, parto precoz o prematuro, disfunciones eréctiles, disfunciones sexuales en el hombre, disfunciones sexuales en la mujer, angina de pecho, hipertensión pulmonar, ataque de apoplejía, arteriosclerosis, insuficiencia ventricular, desórdenes vasculares periféricos, asma, bronquitis, rinitis alérgica, glaucoma o desórdenes de la mortalidad intestinal.
Patent UY-27125-A1 (UY)
Title: Uso de un antagonista de ltb4 para el tratamiento y/o la prevención de enfermedades causadas por aumento de la expresión de genes de mucina
Inventor: ANDERSKEWITZ DR RALF
Filed: 2002-01-15
Abstract: La invención se refiere al uso de un antagonista de LTB4 o una sal farmacéuticamente aceptable del mismo para la preparación de un medicamento para el tratamiento y/o la prevención de enfermedades causadas por aumento de la expresión de genes de mucina y/o hiperplasia de células caliciformes inducidas por toxinas de productos de bacterianas patógenas en el epitelio bronquial o gastrointestinal.
Patent UY-27550-A1 (UY)
Title: Composición para catéter y usos de la misma
Inventor: SEMBRA CHARLES P
IPC: A61K39/395
Filed: 2002-11-26
Abstract: Una composición útil para la remoción de coágulos sanguíneos unidos a fibrina de un catéter que comprende agua, una cantidad fibrinolíticamente efectiva de un activador de plasminógeno y una cantidad preservativamente efectiva de un alcohol orgánico bacteriostático. La composición no comprende un agente quelante.
Patent UY-28051-A1 (UY)
Title: Nuevos compuestos de amida con accion antagonista de mch, y medicamentos que contienen estos compuestos.
Inventor: RUDOLF KLAUS
IPC: C07D213/30
Filed: 2003-10-29
Abstract: La presente invención se refiere a compuestos de amida de fórmula general I en la cual los grupos y radicales A, B,b,W,X,Y,Z,R1, R2 y R3 tienen los significados indicados en la reivindicación 1.La invención se refiere además a medicamentos que contienen al menos una amida de acuerdo con la invención. Gracias a su actividad antagonista hacia receptor de MCH, los medicamentos de acuerdo con la invención son adecuados para el tratamiento de trastornos metabólicos y/o trastornos de la alimentación, en especial la obesidad, bulimia, anorexia, hiperfagia y diabetes.
Patent UY-28100-A1 (UY)
Title: Formulación farmacéutica de liberación inmediata
Inventor: INGHARDT TORD
Filed: 2003-11-27
Abstract: Formulación farmacéutica de liberación inmediata comprendiendo como ingrediente activo, compuesto de fórmula (i): donde R1 represnta alquilo C1-2 substituido por uno o más sustituyentes fluoro; R2 representa hidrógeno, hidroxi, metoxi o etoxi; y n represnta 0, 1 o 2; o una sal farmacéuticamente aceptable del mismo; y duluyente o vehículo farmacéuticamente aceptable ; con condición que cuando el ingrediente activo está en forma distinta de una sal, la formulación no solamente contenga: . una solución de ingrediente activo y agua; . una solución de ingrediente activo y dimetilsulfóxido; o, : una solución de ingrediente activo en mezcla de etanol : estearato de 12-hidroxi PEG 660: agua 5:5:90. : para tratamiento de trastorno cardiovascular.
Patent UY-28141-A1 (UY)
Title: Nuevos derivados de piridazin-3(2h)-ona
Inventor: PIAZ DAL
IPC: C07D403/04
Filed: 2003-12-19
Abstract: Nuevol derivados de piridazin-3(H). 0NA DE FÓRMULA ( I ): en la que R1 y R2 representan independientemente cada uno: un átomo de hidrógeno, que está opcionalmente sustituido con uno o más sustituyentes; R5 representa un grupo éster o un grupoarilo o heteroarilo monocíclico o policíclico que está opcionalmente sustituido con uno o más sustituyentes; R4 representa: un átomo de hidrógeno, un grupo hidroxi o grupos orgánicos o mas de sus sales farmacéuticamente aceptables.
Patent UY-29205-A1 (UY)
Title: Disposición de cierre para una lata
Inventor: ALVARES ANTONIO CARLOS TEIXEIR
Filed: 2005-11-10
Abstract: DISPOSICIÓN DE CIERRE PARA UNA LATA del tipo que presenta un cuerpo tubular (10) de sección transversal circular o poligonal, cerrado en la parte inferior y que comprende: una pared lateral periférica (11) provista de un borde superior (12); y un anillo estructural (13) interno al cuerpo tubular (10) y unido herméticamente a la pared lateral periférica (11), de modo de definir una abertura superior (14) de la lata y un asiento (15) para asentar un elemento de sello (20), donde el anillo estructural (13) está definido por una nervadura circunferencial (16) formada por un receso en la pared lateral periférica (11), retirada axialmente con relación al borde superior (12) de esta última y que se proyecta radialmente hacia dentro del cuerpo tubular (10).