baber/WOPTO huggingface dataset:
Patent AP-2003002922-A0 (AP)
Title: Skin-permeable selective cyclooxygenase-2 inhibitor composition.
Inventor: LU GUANG WEI
IPC: A61K31/465
Filed: 2002-05-30
Abstract: A dermally deliverable pharmaceutical composition comprises at least one selective cyclooxygenase-2 (COX-2) inhibitory drug or prodrug thereof solubilized in a pharmaceutically acceptable carrier that comprises a low molecular weight mono-hydric alcohol, and exhibits a skin permeation rate of the therapeutic agent at feast equal to that exhibited by a reference solution of the therapeutic agent in 70% aqueous ethanol. A method of effecting targeted delivery of a selective COX-2 inhibitory drug to a site of pain and/or inflammation in a subject comprises topically administering such a composition to skin of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation. A method of effecting systemic treatment of a subject having a COX-2 mediated disorder comprises transdermally administering such a composition, preferably by contacting the composition with an area of skin of the subject not greater than about 400 cm2.
Patent MA-25446-A1 (MA)
Inventor: AALTONEN JARMO
IPC: C01B25/234
Filed: 2001-10-18
Abstract: The invention relates to a process for producing simultaneously food-grade and fodder-grade phosphoric acid by crystallizing phosphoric acid hemihydrate, H3PO4 x 0.5 H2O, from a prepurified feed acid, which is purified and crystallized with the help of the following steps, a) after the step of froth-flotation of phosphate concentrate, the concentrate is directed to a strongly magnetic separation step in order to decrease the Mg ion amount, b) the phosphate concentrate is leached in a mixture of sulfuric acid and phosphoric acid according to the wet process, the precipitated SO4 and As ions are removed, and a silicon source is added in order to adjust the F/Si molar ratio to < 6, c) the phosphoric acid is concentrated, the solids precipitate is removed, and the F ions are evaporated, d) the feed acid obtained from step c, having a concentration of > 58% P2O5, solids concentration of < 0.05%, Mg ion concentration of < 1.5%, SO4 ion concentration < 1%, As ion concentration of < 8 ppm and F ion concentration of < 0.2%, is crystallized at a steady crystal growth rate of < 10  mu m/min, the temperature difference in the first crystallization being < 17  DEG C, and the crystals are washed with the undersaturated mother liquor of the subsequent recrystallization step, e) the phosphoric acid crystallized in step d is melted, is diluted to a concentration of < 63% P2O5, seed crystals are added, and crystallization is carried out as in step d, the temperature difference being < 8  DEG C, and the crystals are washed with an undersaturated solution of phosphoric acid, and f) optionally the phosphoric acid crystallized in step e is melted, is diluted to a concentration of < 63% P2O5, seed crystals are added, and crystallization is carried out as in step d, the temperature difference being < 6  DEG C, and the crystals are washed with an undersaturated washing solution prepared from product crystals.
Patent MA-28282-A1 (MA)
Title: Utilisation de derives de n-arylhydrazine pour la lutte contre des parasites chez et sur des animaux
Inventor: VON DEYN WOLFGANG
IPC: A01N37/52
Filed: 2006-07-04
Abstract: Utilisation de dérivés N-arylhydrazine pour la lutte contre des nuisibles dans et sur des animaux Utilisation de composés de formule I dans laquelle Q est X1 est un atome de chlore, un atome de brome, ou un atome de fluor ; R1, R2 sont chacun indépendamment un atome d'hydrogène, un groupe alkyle, un groupe alcényle, un groupe alcynyle, ou un groupe cycloalkyle, un groupe alkylamino, un groupe dialkylamino, un groupe alkylcarbonylamino, un groupe alkylsulfonyle, or un groupe alkylsulfinyle, où les atomes de carbone dans ces groupes peuvent être substitués, ou R1 et R2 peuvent être pris conjointement pour former un noyau représenté par la structure p, m valent 1, 2 or 3 ; X' est un atome d'oxygène, un atome de soufre, un groupe amino, un groupe alkylamino, un groupe phénylamino, or un groupe méthylène ; Z est un groupe alkyle ou un groupe phényle ; R3 est un atome d'hydrogène, un groupe alkyle, un groupe alcényle, un groupe alcynyle, un groupe cycloalkyle, où les atomes de carbone dans ces groupes peuvent être substitués ; R, R4 sont un atome d'hydrogène ou un groupe alkyle, un groupe alkoxycarbonyle, un groupe alkylaminocarbonyle, ou un groupe dialkylaminocarbonyle où les atomes de carbone dans ces groupes peuvent être substitués ; A est un groupe C-R5 ou un atome d'azote ; B est un groupe C-R6 ou un atome d'azote ; W est un groupe C-R7 or un atome d'azote ; à condition que l'un parmi A, B et W soit autre qu'un atome d'azote ; R5, R6, R7 sont un atome d'hydrogène, un atome d'halogène, un groupe nitro, un groupe cyano, un groupe amino, un groupe mercapto, un groupe hydroxy, un groupe alkyle, un groupe alcényle, un groupe alcynyle, un groupe cycloalkyle, un groupe alcoxy, un groupe alkylamino, un groupe dialkylamino, un groupe alkylthio, un groupe alkylsulfonyle, ou un groupe alkylsulfinyle, où les atomes de carbone dans ces groupes peuvent être substitués, un système de noyau aromatique à 5-6 chaînons, qui peut renfermer de 1 to 4 hétéroatomes choisis parmi un atome d'oxygène, un atome de soufre et un atome d'azote, et qui peut être substitué ; Y est un atome d'hydrogène, un atome d'halogène, un groupe cyano, un groupe nitro, un groupe amino, un groupe hydroxy, un groupe mercapto, un groupe alkyle, un groupe alcényle, un groupe alcynyle, un groupe cycloalkyle, un groupe alcoxy, un groupe alkylamino, un groupe dialkylamino, un groupe alkylthio, un groupe alkylsulfonyle, ou un groupe alkylsulfinyle, où les atomes de carbone dans ces groupes peuvent être substitués : n vaut 0, 1, ou 2 ; pour la lutte contre des parasites dans et sur des animaux.
Patent MA-47052-A1 (MA)
Title: Élimination des dépôts dans la production d'acide phosphorique et installations de manipulation
Inventor: BHATTACHARJA SANKAR
IPC: C23F11/173
Filed: 2018-04-19
Abstract: L'invention concerne des compositions et des méthodes d'atténuation de dépôts dans des installations d'acide phosphorique et de phosphate d'ammonium. Les compositions d'atténuation de dépôts de l'invention peuvent être ajoutées à de l'acide phosphorique avant ou pendant la concentration dans le cycle d'évaporation d'une installation d'acide phosphorique. Les compositions retardent la formation de dépôt sur des surfaces en contact avec l'acide phosphorique, et ainsi le temps entre les nettoyages est allongé et la productivité de l'installation augmente. En outre, le dépôt qui se forme est plus mou et plus facilement nettoyé des surfaces, réduisant le temps de non-fonctionnement de l'installation et/ou de l'évaporateur. L'invention concerne également des méthodes d'atténuation de la formation de dépôt dans la production d'acide phosphorique et des installations de manipulation d'acide phosphorique. Dans les méthodes, les dépôts s'accumulent plus lentement et sont plus mous, plus tractables et plus facilement nettoyés des surfaces auxquelles ils adhèrent.
Patent UY-29732-A1 (UY)
Title: Derivados de benzotiazolonas, procesos de preparación, composiciones y combinaciones que los contienen y aplicaciones
Inventor: BONNERT ROGER
IPC: C07D417/12
Filed: 2006-08-08
Abstract: La presente invención proporciona compuestos de fórmula (I) donde e, r1, R2, r3 ,R4, R5, R4, R5, R6, R7, R7a, R7b, ,D, m y n son como se definió en ela especificación, los procesos para su preparación, las composiciones farmacéuticas que los contienen y su uso en terapia.
Patent UY-29948-A1 (UY)
Title: Productos horneados con comprenden edulcorantes de alta intensidad
Inventor: DUBOIS GRANT E
IPC: A23L27/30
Filed: 2006-11-21
Abstract: Alimentos al horno que comprenden edulcorantes no calóricos o hipocalóricos de alta potencia y los métodos para hacerlos y usarlos. En particular, la invención refiere a diferentes alimentos al horno que comprenden al menos un edulcorante natural y/o sintético no calórico o hipocalórico de alta potencia y al menos una composición para mejorar el sabor dulce.
Patent UY-30137-A1 (UY)
Title: Monohidrato de rimonabant, su procedimiento de preparación y composiciones farmacéuticas que lo contienen
Inventor: PHILIPPE OCHSENBEIN
IPC: A61K31/454
Filed: 2007-02-08
Abstract: La presente invención tiene por objeto monohidrato de rimonabant, su procedimiento de preparación y las composiciones farmacéuticas que lo contienen.
Patent CA-1263000-A1 (CA)
Title: Derivatives of 2-azabicyclo[3.1.0]hexane-3-  carboxylic acid, a process for their preparation,  agents containing them and their use; and 2-  azabicyclo[3.1.0]hexane derivatives as  intermediates, and a process for their preparation
Inventor: URBACH HANSJOERG
IPC: C07D209/52
Filed: 1984-07-05
Abstract: Abstract of the disclosure:         The invention relates to compound of the formula I               (I) in which n denotes 0 or 1, R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined previously, a monocyclic or bicyclic S- or O- and/radical N-heterocyclic radical or a side chain of an aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, acylamino, alkyl-amino, dialkylamino and/or methylenedioxy, or 3-indolyl, and to a process for their preparation, agents containing them and their use, and to 2-azabicyclo [3.1Ø] hexane derivatives as inter-mediates, and a process for their preparation.  The compounds of the formula I and their salts have a long-lasting and strong hypotensive effect.  They are potent inhibitors of angiotensin converting enzyme (ACE inhibitors) and can be employed to control hypertension of a variety of etiologies.
Patent ES-178723-A1 (ES)
Title: Mejoras en o relativas a soportes de aparatos
IPC: G01R11/04
Filed: 1947-07-02
Abstract: Mejoras en soportes de aparatos caracterizadas por una unidad de aparatos para equipos telefónicos y semejantes que comprenden una unidad protectora moldeada que forma cámara a prueba de polvo y encierra el equipo montado en el interior,unido por un procedimiento de guia a y montado sobre un bloque de conexión y haciendo una variedad de contactos con ellos y teniendo un miembro desmontable para dar acceso a los extremos del cableado del equipo.
Patent ES-179166-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN DE AZULEJOS CERáMICOS CON DIBUJOS EN RELIEVE POLICROMADOS
Filed: 1947-07-31
Abstract: Por un procedimiento par ala obtención de azulejos cerámicos, con dibujos en relieve policromados, que se caracteriza porque los moldes se preparan tallando en madera, especialmente en la de peral, el motivo artístico en bajo-relieve, pudiéndose también preparar por pirograbado, cincografía y aguafuerte, o también con azufre fundido, escayola cemento portland o fundición de hierro.
Patent ES-184903-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN DE áCIDO FULMiNICO BAJO FORMA ALDEHiDICA
Filed: 1948-08-13
Abstract: Procedimiento para la obtención del ácido fulmínico bajo forma aldehídica caracterizado porque el líquido que resulta después de hacer borbotar una corriente de gas amoniaco anhidro (NH3) en un recipiente que contiene formol comercial al 40% (que absorbe ávidamente el NH3 hasta que de la superficie se desprenden francamente vapores amoniacales) se evapora al vacío hasta reducirlo a la tercera parte de su volúmen primitivo. Realizado esto se retira del aparato de vacío y se trata inmediatamente en la proporción de doble cantidad de su volúmen con agua oxigenada con una riqueza de 30% de oxigeno procediendo durante la adición de la misma a enfriar la masa mediante una refrigeración suficiente para frenar el calor de la reacción e impedir que la temperatura exceda de 30º C.
Patent ES-187324-A1 (ES)
Title: UN DISPOSITIVO PARA RECTIFICAR VáLVULAS A MANO
Filed: 1949-03-05
Abstract: Dispositivo para rectificar válvulas a mano caracterizado porque consiste en un portaválvulas montado giratorio sobre un carro deslizante en una cola de milano practicada en una bancada en la que descansa todo el sistema El carro avanza accionado por un tornillo montado en la cabecera de la cola y el portaválvulas lleva dos soportes dotados de cojinetes partidos angulares para fijar las válvulas por su tallo con tolerancia de diámetro.
Patent ES-192407-A1 (ES)
Title: MEJORAS EN LA CONSTRUCCIoN DE BOMBAS ROTATIVAS AUTOASPIRANTES
Filed: 1950-04-04
Abstract: Mejoras en la construcción de bombas rotativas autoaspirantes con rueda de paletas en forma de estrella con un gran sector de canal para el transporte de agua y un sector de canal adyacente pequeño para el transporte de aire caracterizadas porque el canal de transporte de agua del sector de agua está constituido como un canal de transporte de agua del sector de agua está constituido como un canal lateral concéntrico exteriormente que trabaja con puro efecto de fuerza centrífuga y el canal del sector de aire adyacente al mismo emboca en el espacio de presión o en la salida del canal de transporte de agua.
Patent ES-192514-A1 (ES)
Title: UN PERFECCIONAMIENTO EN LOS APARATOS CENTRIFUGADORES PARA INYECCIoN DE METAL FUNDIDO
Filed: 1950-03-28
Abstract: Perfeccionamiento en los aparatos centrifugadores para inyección de metal fundido que consiste esencialmente en montar en el interior del pie o soporte de los brazos portadores del metal fundido a inyectar un dispositivo de blocaje o freno constituido por una rueda dentada solidaria del eje unido al muele del aparato con cuya rueda puede engranar o acoplarse un trinquete formado por un vástago desplazable por el interior de un casquillo solidario de la pared de la base o soporte general cuyo vástago es protador de un botón exterior para su accionamiento y de un resorte interior que tiende a mantenerlo continuamente en contacto con los dientes de la rueda central constituyendo este conjunto un piñón de libre giro en un solo sentido gracias a la punta en plano inclinado que presenta el referido trinquete.
Patent ES-198956-A1 (ES)
Title: UNA MáQUINA REPRODUCTORA DE TALLAS DE MADERA
Filed: 1951-07-26
Abstract: Máquina reproductora de tallas de madera caracterizada por constar en su carro que va montado por medio de varios juegos de rodillos sobre dos guías transversales con respecto a una plataforma dotada de movimientos de avance y retroceso en profundidad así como de desplazamientos en altura obtenidos por medios convenientes.
Patent ES-261027-A1 (ES)
Title: Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
IPC: C07D/
Filed: 1960-09-03
Abstract: The invention comprises compounds of general formula <FORM:0908788/IV (b)/1> wherein X represents -CH2-CH2-or-CH= CH- Y and Z represent hydrogen, halogen, or alkyl (1 to 4 carbon atoms) alkylene represents a straight or branched chain with 2-6 carbon atoms and R represents an alkyl, cycloalkyl or alkenyl group (maximum of 8 carbon atoms each), and processes for their production (1) by reaction of a reactive ester of a hydroxy compound of general formula <FORM:0908788/IV (b)/2> with a primary amine of general formula NH2-R III (2) by reaction of a compound of general formula <FORM:0908788/IV (b)/3> with an aliphatic oxo compound which may be saturated or may contain a double linkage, and reduction of the product, (3) by reduction of a compound of general formula <FORM:0908788/IV (b)/4> wherein alkylene1 and R1 differ from alkylene and R as defined above only in that, in at least one of these radicals, the group bound to a nitrogen atom is a carbonyl group, (4) by splitting into an acid and a secondary amine an amide of general formula <FORM:0908788/IV (b)/5> wherein Ar represents an acyl radical and (5) by catalytic reduction of a compound of general formula <FORM:0908788/IV (b)/6> wherein Av represents an arylmethyl radical. The products have antiallergic, spasmolytic, anticonvulsive and sedative activity. Acyl derivatives of general formula V are prepared, for example, by acylation of amines of general formula IV Acyl derivatives of general formula VI are prepared, for example, by reaction of alkali metal derivatives of compounds of general formula V with reactive esters (such as halides) of low molecular weight alkanols or alkenols by reaction of compounds of general formula <FORM:0908788/IV (b)/7> with reactive esters of alcohols of general formula <FORM:0908788/IV (b)/8> or by reaction of reactive esters of alcohols of general formula II with amides of general formula <FORM:0908788/IV (b)/9> Imides reducible to compounds of general formula I are prepared by reaction of appropriate oxo compounds (aldehydes or ketones) with amino compounds of general formula IV. 5-g -Chloropropyldibenz[b,f]azepine is prepared by reaction of g -chloropropyl bromide with the sodium derivative formed by reaction of sodium amide with dibenz[b,f]azepine.
Patent ES-293449-A1 (ES)
Title: Control system for ground effect vehicles
IPC: B60V1/00
Filed: 1963-11-12
Abstract: A ground effect machine provided with a flexible skirt extending entirely or for the most part around the periphery of the ground effect machine has means for deflecting the flexible skirt at one or more selected points thereof to attenuate the air cushion at each selected point, severally or in combination thereby inducing a force at each selected point tending to cause the machine to move towards that point, the resultant of the forces acting at each selected point inducing a change in the direction of motion of the machine. The vehicle comprises a deck 19, buoyancy tank 20, cabin 27, fan 18, driving propeller 26, peripheral skirting 10 and stability keel 14. The skirt 10 has an outer wall 11 and inner wall 12 connected by diaphragms to form separate ducts or supply nozzles 21. Four fluid pressure jacks 25 are mounted on deck 19, the rams being connected to cables 23 which run over pulleys 24 for connection to the outer and/or inner walls of the skirt, whereby the skirt may be deflected or distorted locally as shown by dotted lines in Fig. 8 to vary the size or height of the supply nozzle 21. Similar adjustment of the stability keel 14 may be effected as shown in Fig. 13, wherein the walls 15, 16 are connected by a chain 71 attached to a cable 70. Each jack 25 has an electrically operated valve with an independent control C, though they may be operated by a common member W. The system includes an hydraulic fluid tank 31, pump 32, filter 33, cut-out mechanism 34 and overflow tank 35. Specifications 860,781, 925,425, 929,671, 939,869, 946,084, 946,611, 974,636, 975,193, 975,194 and 975,195 are referred to.
Patent ES-294657-A1 (ES)
Title: Improvements in or relating to novel anthracene derivatives
IPC: A61K31/445
Filed: 1963-12-19
Abstract: Novel compounds of the general Formula I <FORM:1060466/C2/1> (wherein each of R1 and R2 represents a C1- 4 alkyl or C2- 4 alkenyl radical and R3 represents a C1- 4 alkyl radical), and their acid addition salts, are prepared by splitting off the elements of water from a compound of the general Formula IV <FORM:1060466/C2/2> by the action of a concentrated mineral acid, a strong organic acid, SOCl2, POCl3, ZnCl2 or acetic anhydride, or a mixture thereof (especially a mixture of acetic anhydride and concentrated HCl), and, if desired, converting the product into a salt with an inorganic or organic acid. Substituted 9 - hydroxydihydroanthracenes (IV) are prepared by a Grignard reaction from 10-R1-10-R2-anthrones-(9). Pharmaceutical compositions having antihistaminic, cough inhibiting, bronchodilatory, serotonin inhibiting, anticholinergic and/or sedative properties, for enteral or parenteral administration, comprise a compound of general Formula I, or a physiologically acceptable acid addition salt thereof, and a physiologically acceptable carrier.
Patent ES-306340-A1 (ES)
Title: Method of separation of uranium from plutonium
IPC: C22B60/04
Filed: 1964-11-24
Abstract: Uranium and plutonium are separated from one another by contacting a tributyl phosphate organic phase containing uranyl nitrate and plutonium (IV) nitrate with an aqueous phase containing nitrate and sulphate anions so that plutonium selectively passes into the aqueous phase. The organic phase may be a mixture of 20% tributyl phosphate in dodecane and may contain 0.005-5 grams/litre Pu and 10-130 grams/litre U. The sulphate ions in the aqueous phase are provided by sulphuric acid or a soluble sulphate. The contacting is suitably carried out in a multiple-stage arrangement of mixer-settlers.
Patent ES-309326-A1 (ES)
Title: Frame for holding a bag
IPC: B65B67/12
Filed: 1965-02-13
Abstract: A holder for a plastic foil bag for refuse, consists of an upper frame 6, holding the mouth of the bag open, and a lower frame, support. ing the closed base of the bag and formed by frames 1, 2, connected to each other by stiffeners 3, 4 and to the upper frame by supports 5, and a rotatable magazine roller 12. carrying a web of bags which are separated from each other by transverse seams and tear lines 14, the holder being formed with an opening through which the web is drawn upwardly for replacement of a fitted bag by an empty one. The holder is of plastic-coated wire and the frame 6 has an aperture 7 so that it resiliently compresses for the folding over of the mouth 15 of a bag. The roller is supported on extensions 11 of two of the supports 5 and the opening through which the web is drawn is defined by a bar 9, and a bar 10 of a support 8, the bars being welded to the ends of stiffeners 4. Eyes 17 are provided for mounting the framework on a door, wall &c. and, in modifications, the framework is supported on the floor, the roller is supported in a tubular or trough-shaped container and the mouth of the bag is secured to the upper frame by means other than folding over.
Patent ES-334662-A1 (ES)
Title: Vapor generator construction
IPC: F22B37/66
Filed: 1966-12-19
Abstract: A once through or forced recirculation supercritical vapour generator has its furnace walls lined with tangent or finned tubes 40, backed by furnace insulation 42 and horizontally extending stiffener members 44 all supported by the furnace tubes. A cage of vertically extending I beams 50 supported independently of the furnace walls from structural steel work 46, surrounds the furnace walls in sliding contact with the stiffener members 44, which I-beams 50 are inter-connected at several horizontal levels by buckstays, such as 58, 60, 62, 64 extending along the furnace walls and welded to the vertical I beams 50. Opposed buckstays e.g. 58 and 60, or 62 and 64 are inter-connected at their ends by fluid carrying members 80 and 82, or 76 and 78, which pass through holes in the vertical I beams 50, in such a way as to allow for expansion and contraction on heating and cooling of the furnace walls. Thus each buckstay e.g. 58 is secured to its respective fluid carrying member e.g. 80 by a pair of rods 84 which pass through openings 85 in the buckstay, and openings in a collar 86 secured to the fluid carrying member. Rockers 88 and nuts 90 are then threaded on to the ends of the rods 84. The fluid carrying members 76, 78, 80 and 82 form part of downcomer circuit, in parallel with main downcomer 22 extending between the upper outlet headers of the tubes of a furnace division wall 20, and lower inlet headers of the furnace wall tubes 40. In this way the expansion of the fluid carrying members on heating is kept at the same order as that of the tube walls.