Patent SG-11201408047X-A (SG)
Title: Macrocyclic inhibitors of flaviviridae viruses
Inventor: ACIRO CAROLINE
IPC: C07D498/18
Filed: 2013-06-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185103 A1 (51) International Patent Classification: C07D 487/18 (2006.01) A61P 31/12 (2006.01) C07D 498/18 (2006.01) A61P 35/00 (2006.01) A61K31/504 ( 2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: PCT/US2013/044826 7 June 2013 (07.06.2013) English (26) Publication Language: (30) Priority Data: 61/657,550 8 June 2012 (08.06.2012) English US (71) Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, California 94404 (US). SEL- CIA LIMITED [GB/GB]; Fyfield Business & Research Park, Fyfield Road, Ongar Essex CM5 0GS (GB). (72) Inventors: ACIRO, Caroline; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). STEADMAN, Victoria Alexandra; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). PETTIT, Simon Neil; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). POULLENNEC, Karine G.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). LAZARIDES, Linos; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DEAN, David Kenneth; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DUN­ BAR, Neil Andrew; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). HIGHTON, Adrian John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KEATS, Andrew John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SIEGEL, Dustin Scott; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KARKI, Kapil Kumar; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SCHRIER, Adam James; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). JANSA, Petr; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). MACKMAN, Richard; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). (74) Agents: SHEPPARD MULLIN RICHTER & HAMP­ TON LLP et al.; 379 Lytton Avenue, Palo Alto, CA 94301-1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, [Continued on next page] (54) Title: MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES o T-H oo (57) Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis infections. C WO 2013/185103 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll llll lllll llll lllllll llll llll BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))