Patent SG-11201908786V-A (SG)
Title: Substituted indoline derivatives as dengue viral replication inhibitors
Inventor: KESTELEYN BART RUDOLF ROMANIE
IPC: A61P31/14
Filed: 2018-03-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I ill mu °million °nolo VII IE (10) International Publication Number WO 2018/178240 Al PCT (51) International Patent Classification: CO7D 403/12 (2006.01) A61P 31/14 (2006.01) A61K 31/41 (2006.01) (21) International Application Number: PCT/EP2018/058079 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17164048.5 31 March 2017 (31.03.2017) EP (71) Applicants: JANSSEN PHARMACEUTICALS, INC. [US/US]; 1125 Trenton-Harbourton Road, Titusville, NJ New Jersey 08560 (US). KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; Waaistraat 6, bus 5105, 3000 Leuven (BE). (72) Inventors: KESTELEYN, Bart Rudolf Romanie; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). BONFANTI, Jean-Francois; c/o Janssen-Cilag 1 rue Camille Desmoulins, TSA 91003, 92787 Issy-les-Moulin- eaux Cedex 9 (FR). COESEMANS, Erwin; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). RABOISSON, Pierre Jean-Marie Bernard; c/o Janssen Pharmaceutica NV Turnhoutseweg 30, 2340 Beerse (BE). MARCHAND, Arnaud Didier M; c/o Cistim Leuven vzw Gaston Geenslaan 2, 3001 Leuven (Heverlee) (BE). BARDIOT, Dorothee Alice Marie-Eve; c/o Cistim Leu- ven vzw Gaston Geenslaan 2, 3001 Leuven (Heverlee) (BE). (74) Agent: GHEDIRA, Rim; Johnson & Johnson Patent Law Department, Turnhoutseweg 30, 2340 Beerse (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) CZ el (54) Title: SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS I N (57) : The present invention relates to substituted indoline derivatives, methods to prevent or treat dengue viral infections by 1-1 ----. using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the © compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral N infections. The invention also relates to processes for preparation of the compounds.