Patent SG-11201908330P-A (SG)
Title: Farnesoid x receptor agonists and uses thereof
Inventor: SMITH NICHOLAS D
IPC: A61K31/416
Filed: 2018-03-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT omit VIII °nolo olomollm OH 00100 oimIE (10) International Publication Number WO 2018/170182 Al (51) International Patent Classification: CO7D 417/12 (2006.01) A61K 31/426 (2006.01) CO7D 403/12 (2006.01) A61K 31/416 (2006.01) C07D 401/12 (2006.01) A61P 1/16 (2006.01) A61K 31/4439 (2006.01) (21) International Application Number: PCT/US2018/022513 (22) International Filing Date: 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,511 15 March 2017 (15.03.2017) US 62/471,525 15 March 2017 (15.03.2017) US 62/471,517 15 March 2017 (15.03.2017) US 62/563,488 26 September 2017 (26.09.2017) US 62/563,502 26 September 2017 (26.09.2017) US (71) Applicant: METACRINE, INC. [US/US]; 3985 Sorrento Valley Blvd., Suite C, San Diego, California 92121 (US). (72) Inventors: SMITH, Nicholas D.; 3985 Sorrento Valley Blvd., Suite C, San Diego, California 92121 (US). GOV- EK, Steven P.; 3985 Sorrento Valley Blvd., Suite C, San Diego, California 92121 (US). NAGASAWA, Johnny Y.; 3985 Sorrento Valley Blvd., Suite C, San Diego, Califor- nia 92121 (US). DOUGLAS, Karensa L.; 3985 Sorrento Valley Blvd., Suite C, San Diego, California 92121 (US). LAI, Andiliy G.; 3985 Sorrento Valley Blvd., Suite C, San Diego, California 92121 (US). (74) Agent: ZUNIC, Valentin B.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, 00 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, O UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, N 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 00 (54) Title: FARNESOID X RECEPTOR AGONISTS AND USES THEREOF 11 <= (57) : Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharma- \" ceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of con- \" ditions, diseases, or disorders associated with farnesoid X receptor activity.