Patent AU-576782-B2 (AU)
Title: Preparation of n-alkylated dipeptides
Inventor: TEETZ VOLKER
IPC: C07K1/08
Filed: 1984-09-14
Granted: 1988-09-08
Abstract: 1. A process for the preparation of compounds of the formula I   see diagramm : EP0135182,P12,F1   in which n is 1 or 2, R denotes hydrogen, alkyl having 1-8 carbon atoms, alkenyl having 2-6 carbon atoms, cycloalkyl having 3-9 carbon atoms, aryl which has 6-12 carbon atoms and can be mono-, di- or trisubstituted by (C1 -C4 )-alkyl, (C1 -C3 )-alkoxy, hydroxyl, halogen, nitro, amino, aminomethyl, (C1 -C4 )-alkylamino, di-(C1 -C4 )-alkylamino, (C1 -C4 )-acylamino, preferably (C1 -C4 )-alkanoylamino, methylenedioxy, carboxyl, cyano and/or sulfamoyl, alkoxy having 1-4 carbon atoms, aryloxy which has 6-12 carbon atoms and can be substituted as described above for aryl, mono- or bicyclic heteroaryloxy which has 5-7 or 8-10 ring atoms respectively, 1 to 2 of the ring atoms representing sulfur or oxygen atoms and/or 1 to 4 ring atoms representing nitrogen, and which can be substituted as described above for aryl, amino-(C1 -C4 )-alkyl, (C1 -C4 )-alkanoyl-amino-(C1 -C4 )-alkyl, (C7 -C13 )-aroylamino-(C1 -C4 )-alkyl, (C1 -C4 )-alkoxy-carbonylamino-(C1 -C4 )-alkyl, (C6 -C12 )-aryl-(C1 -C4 )-alkoxycarbonylamino-(C1 -C4 )- alkyl, (C6 -C12 )-aryl-(C1 -C4 )-alkylamino-(C1 -C4 )-alkyl, (C1 -C4 )-alkylamino-(C1 -C4 )-alkyl, di-(C1 -C4 )-alkylamino-(C1 -C4 )-alkyl, guanidino-(C1 -C4 )-alkyl, imidazolyl, indolyl, (C1 -C4 )-alkylthio, (C1 -C4 )-alkylthio-(C1 -C4 )-alkyl, (C6 -C12 )-arylthio-(C1 -C4 )-alkyl which can be substituted in the aryl moiety as described above for aryl, (C6 -C12 )-aryl-(C1 -C4 )-alkylthio which can be substituted in the aryl moiety as described above for aryl, carboxyl-(C1 -C4 )-alkyl, carboxyl, carbamoyl, carbamoyl-(C1 -C4 )-alkyl, (C1 -C4 )-alkoxy-carbonyl-(C1 -C4 )-alkyl, (C6 -C12 )-aryloxy-(C1 -C4 )-alkyl which can be substituted in the aryl moiety as described above for aryl, or (C6 -C12 )-aryl-(C1 -C4 )-alkoxy which can be substituted in the aryl moiety as described above for aryl, R**1 denotes hydrogen, alkyl having 1-6 carbon atoms, alkenyl having 2-6 carbon atoms, alkynyl having 2-6 carbon atoms, cycloalkyl having 3-9 carbon atoms, cycloalkenyl having 5-9 carbon atoms, (C3 -C9 )-cycloalkyl-(C1 -C4 )-alkyl, (C5 -C9 )-cycloalkenyl(C1 -C4 )-alkyl, optionally partially hydrogenated aryl which has 6-12 carbon atoms and can be substituted as described above for R, (C6 -C12 )-aryl-(C1 -C4 )-alkyl or (C7 -C13 )-aroyl-(C1 or C2 )-alkyl, both of which can be substituted as the preceding aryl, mono- or bicyclic, optionally partially hydrogenated heteroaryl which has 5-7 or 8-10 ring atoms respectively, 1 to 2 of these ring atoms representing sulfur or oxygen atoms and/or 1 to 4 ring atoms representing nitrogen atoms, which can be substituted as the preceding aryl, or, the protected side chain of a naturally occurring alpha-amino acid R**1 -CH(NH2 )-COOH, R**2 and R**3 are identical or different and denote hydrogen, alkyl having 1-6 carbon atoms, alkenyl having 2-6 carbon atoms, di-(C1 -C4 )-alkylamino-(C1 -C4 )-alkyl, (C1 -C5 )-alkanoyloxy-(C1 -C4 )-alkyl, (C1 -C6 )-alkoxy-carbonyloxy-(C1 -C4 )-alkyl, (C7 -C13 )-aroyloxy-(C1 -C4 )-alkyl, (C6 -C12 )-aryloxycarbonyloxy-(C1 -C4 )-alkyl, aryl having 6-12 carbon atoms, (C6 -C12 )-aryl-(C1 -C4 )-alkyl, (C3 -C9 )-cycloalkyl or (C3 -C9 )-cycloalkyl-(C1 -C4 )-alkyl, and R**4 and R**5, together with the atoms carrying them, form a heterocyclic mono-, bi- or tricyclic ring system having 3 to 15 carbon atoms, which comprises compounds of the formula II   see diagramm : EP0135182,P12,F2   in which n, R, R**1 and R**2 have the meanings defined above, being reacted in the presence of a phosphinic anhydride of the formula III   see diagramm : EP0135182,P13,F1   in which R**6 , R**7 , R**8 and R**9 are identical or different and represent alkyl and/or aralkyl, with compounds of the formula IV   see diagramm : EP0135182,P13,F2   in which R**3 , R**4 and R**5 have the meanings defined above, where appropriate radicals which have been introduced to protect other functional groups being eliminated and, where appropriate, free carboxyl groups being esterified in a manner known per se.