baber/WOPTO huggingface dataset:
Patent JP-S61163917-A (JP)
Title: Stable dispersion of polyurea and/or polyhydrazodicarbonamide dispersed in hydroxyl group-containing material with relatively large molecular weight, its production and use thereof in production of polyurethane plastic
Inventor: MANFURETO DEIITORITSUHI
IPC: C08G18/62
Filed: 1986-01-08
Abstract: The present invention is directed to a stable dispersion of a polyurea and/or a polyhydrazodicarbonamide in a relatively high molecular weight hydroxyl-group containing material, which dispersion has a solids content of from 5 to 50 percent by weight and which is obtained by reacting (a) an organic di- and/or polyisocyanate with (b) an amine-functional material comprising an addition product of (1) acrylonitrile and (2) a member selected from the group consisting of (i) hydrazine, (ii) aliphatic di- or polyamines containing at least two primary amino groups, (iii) cycloaliphatic di- or polyamines containing at least two primary amino groups, (iv) araliphatic di- or polyamines containing at least two primary amino groups, and (v) mixtures thereof,  the ratio of (1) to (2) being at least one mol of (1) per mol of (2) and at most one mol of (1) for each nitrogen atom contained in (2) per mol of (2), the reaction of component (a) and component (b) being conducted at a temperature of from 30 DEG  to 170 DEG  C., at an equivalent ratio of components (a) to (b) of from 0.8:1 to 1.5:1, and in the presence of (c) a relatively high molecular weight, hydroxyl-group containing material. The invention also relates to the production and use of such dispersions.
Patent JP-H06209563-A (JP)
Title: Power conversion system
Inventor: SHIBATA MITSUHIRO
IPC: H02J3/18
Filed: 1993-01-07
Abstract: PURPOSE:To improve the efficiency and downsize a system by reducing the power loss of a power conversion system being equipped with a plurality of power converters connected to a common power bus and supplying load with power. CONSTITUTION:This power conversion system is provided, at each power converter 3-5, with a power converter 11, which supplies load with converted control power, being coupled with a power bus, a snubber power extracting means 12, which extracts the snubber power generated accompanying the power converting operation, and a snubber power accumulating means 13, which accumulates the extracted snubber power temporarily, and besides this system is provided with a common snubber power regenerating means 2, which collects the snubber power accumulated in the snubber power accumulating means of each power converter and regenerates en block in the said power bus.
Patent JP-H11193643-A (JP)
Title: Asbestos removing device, removing head and removing tool
Inventor: TANAKA AKIO
IPC: E04F21/00
Filed: 1998-01-06
Abstract: PROBLEM TO BE SOLVED: To provide an asbestos removing device, a removing head and a removing tool which can restrain the scattering of an asbestos to the utmost and carry out a removing work efficient economically and in pont of time. SOLUTION: An asbestos removing device is a device for removing an asbestos provided on the wall face of a building, and is equipped with a moving truck 10, an articulated arm 11 and a removing head 12. The articulated arm 11 is turnably provided on the moving truck 2 and oscilatabily supports the removing head 12. The removing head 12 is equipped with a removing head case 30, an asbestos removing tool 31 and a bubble injection pipe 32. The asbestos removing tool 31 is equipped with a trapezoid member and a cutting member, and rotatably provided inside the removing head case 30. The cutting member is formed in a bent belt-shape and has a plurality of projections on the outside. The cutting member is attached to the outer edge of the trapezoid member at one end and mutually connected at the other end. The bubble injection pipe jets a bubble consistingof a drug to prevent the scattering of asbestos removed pieces.
Patent JP-S57114637-A (JP)
Title: Soft magnetic material and its manufacture
Inventor: TAKEDA YOSHINOBU
IPC: H01F1/14
Filed: 1981-01-06
Abstract: PURPOSE: To obtain a soft magnetic body with high strength and specific resistance by bonding the particles of a green compact of Fe-Si alloy powder together with oxide by treatment with superheated steam.  
     CONSTITUTION: Fe-Si alloy powder consisting of 0.3W7.0% Si, ≤0.02% C and the balance Fe is die-pressed and treated with superheated steam at about 500W 600°C. Thus, the particles are bonded together with Fe-base oxide, and they are insulated with each other. Among Fe-base oxides Fe 2 O 3  has the highest specific resistance but is lacking in adhesion and does not firmly bond the Si-contg. particles together. FeO is brittle and has inferior adhesion and relatively low specific resistance. Fe 3 O 4  has a dense structure and high adhesion and is 1,000 times as high as Fe in specific resistance. During treatment with superheated steam, various kinds of oxides are produced. FeO is remarkably produced at  ≥600°C, and Fe 3 O 4  is produced at a temp. is said range.  
     COPYRIGHT: (C)1982,JPO&Japio
Patent MA-44326-A (MA)
Title: Dispositif de connexion électrique d'installation photovoltaïque
Inventor: GERON LAURENT
Abstract: L'invention concerne un panneau de parement extérieur pour bâtiment comprenant: un bord transversal supérieur comprenant une zone de recouvrement supérieure destinée à être recouverte par un panneau adjacent, un bord transversal inférieur comprenant une zone de recouvrement inférieure destinée à recouvrir un panneau adjacent, une partie couverte par au moins un module photovoltaïque, et une ouverture située dans la zone de chevauchement supérieure et dans laquelle une boîte de jonction électrique est insérée.
Patent PH-24596-A (PH)
Title: Embossed panty liner
Inventor: LUCERI HOMAS JOSEPH
IPC: A41B17/00
Filed: 1983-09-02
Abstract: A thin absorbent undergarment liner is provided which exhibits a clear, aesthetically pleasing embossed pattern on the body facing surface thereof while still maintaining the longitudinal edges soft and comfortable. The liner is provided to have areas of deep depressions on the body facing surface and shallow impressions on the longitudinal edges.
Patent PH-26198-A (PH)
Title: Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
Inventor: TANNER DANIEL J
IPC: A61K38/21
Filed: 1987-05-25
Abstract: Human basal cell carcinoma is successfully treated by intralesional administration of recombinant human alpha interferon, especially interferon alfa-2b. The preparation of suitable pharmaceutical compositions is disclosed.
Patent UY-33283-A (UY)
Title: Derivados de 2,3-dihidro-1h-inden-1-il-2,7-diazaspiro[3.5]nonano
Inventor: BHATTACHARYA SAMIT KUMAR
IPC: A61K31/438
Filed: 2011-03-18
Abstract: La presente invención proporciona un compuesto de Fórmula (I) o una sal del mismo farmacéuticamente aceptable, en la que R1, R2, Ra, L, Z, Z1 y Z2 son como se ha definido en la presente memoria descriptiva, que actúan como antagonistas o agonistas i nversos de la grelina; composiciones farmacéuticas del mismo; y procedimientos de tratar enfermedades, trastornos o afecciones mediadas por el antagonismo del receptor de la grelina.
Patent UY-33973-A (UY)
Inventor: GERHARD KOENIG
IPC: A61K31/553
Filed: 2012-03-26
Abstract: FORMULA IV PAGINA 3
Patent UY-35565-A (UY)
Title: Método y equipo para producir celulosa nanofibrilar
Inventor: MARKUS NUOPPONEN
IPC: D21H11/18
Filed: 2014-05-13
Abstract: En un método para producir celulosa nanofibrilar, el material de fibra a base de celulosa en dispersión es procesado para separar fibrillas. El método comprende: una primera etapa en la que el material de fibra se suministra a un dispersor (10), don de circula a través de varios rotores contrarrotatorios, de modo tal que el material es sometido repetidamente a fuerzas de corte y de impacto por el efecto de los diferentes rotores contrarrotatorios; y una segunda etapa en la que el material de fibra obtenido de la primera etapa se suministra a un homogeneizador (11), donde es sometido a homogeneización por efecto de la presión.
Patent UY-37778-A (UY)
Title: NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN
Inventor: CALDARELLI MARINA
IPC: C07D487/04
Filed: 2018-06-21
Abstract: Nuevo fosfato de N-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2- metoxifenil}amino)-1-metil-4,5-dihidro-1H-pirazolo[4,3-h]quinazolina-3-carboxamida de fórmula (II): Medicamentos
Patent UY-38312-A (UY)
Title: Variante de ácido nucleico de los genes de 4-cumarato-coa-ligasa (4cl) para modificación de biosíntesis de lignina por supresión con sentido
Inventor: GERMAN SPANGENBERG
IPC: C12N15/82
Filed: 2019-07-23
Abstract: La presente invención se refiere a la modificación de la de lignina en plantas, a las enzimas que intervienen en la vía de biosíntesis de lignina y a los ácidos nucleicos que codifican dichas enzimas y, más particularmente, a métodos para modificar la biosíntesis de lignina por supresión con sentido y a los ácidos nucleicos y construcciones relacionados.
Patent UY-38797-A (UY)
Title: Anticuerpos inmunomoduladores y métodos de uso de los mismos
Inventor: KAMAL D PURI
IPC: C07K16/30
Filed: 2020-07-20
Abstract: En la presente memoria se dan a conocer anticuerpos y métodos de uso de los mismos. Los anticuerpos que se dan a conocer en la presente memoria se unen a CD163+ sobre las células, como tal como sucede con los macrófagos. Dichos anticuerpos pueden utilizarse en métodos de tratamiento, tales como métodos para tratar cáncer.
Patent UY-38865-A (UY)
Title: Motor de 2 y 4 tiempos de alto rendimiento, no contaminante
Inventor: MIGUEL HUGO RUCHI VAZ
IPC: F02B29/08
Filed: 2020-08-28
Abstract: La creación consiste en un motor de movimiento alternativo de dos tiempos con válvulas, de alto rendimiento que para obtener mayor flexibilidad se combina con el ciclo de cuatro tiempos. Presenta un proceso de tratamiento de los gases atmosféricos y de los gases resultantes, que incluyen la recuperación de la energía proporcionada por los combustibles para funcionar del modo mas eficaz y eficiente. Tiene una combustión completa, ubicada y controlada en su temperatura. Libre de aceite lubricante evitando la oxidación del nitrógeno.
Patent UY-39526-A (UY)
Title: Inhibidores de kras g12d
Inventor: ZHANG HAO
IPC: C07D498/08
Filed: 2021-11-19
Abstract: La invención se relaciona con inhibidores de KRAS G12D de la fórmula (I), una composición que contiene los inhibidores, una prodroga de los mismos, un compuesto PROTAC de los mismos y el uso de los mismos.
Patent YU-16698-A (YU)
Inventor: DRAGAN PETKOV
Filed: 1998-04-15
Abstract: Koturaljka sa valjkom i kočnicom, obuhvata levi i desni simetrično oblikovani nosač (1L, 1D) sa gornjom površinom (1a) i podužnom središnom osom prednjeg dela (1b), pomerenom na levu odnosno desnu stranu u odnosu na središnu osu petnog dela (4) za veličinu ekscentričnosti (e) stopala, pri čemu su na prednjem (1b) svakog nosača (1L, 1D) izvedene bočne stranice (3) sa otvorima (6) u kojima su postavljeni vijci (8) u kojima je učvršćena osovina (10) sa uležištenim glavnim valjkom (2). Istovremeno na petnom delu (4) svakog nosača (1L, 1D) izvedene su bočne strane (4a) sa otvorima (7) u kojima su postavljeni vijci (9) u kojima je učvršćena osovina (13) na kojoj je uležišten pomoćni valjak (16) dok je na krajnjem delu petnog dela (4) svakog nosača (1L, 1D), uvrnuta svojim vijkom (18) postavljena kočnica (17) sa pod odredjenim uglom zakošenim bazisom (19) svoga tela (17a) oblika kupe.
Patent YU-26795-A (YU)
Title: Naprava za ručno odvajanje svinjske kože od slanine i sečenje slanine
Inventor: MIHAILO RADOJICIC
Filed: 1995-04-28
Abstract: NAPRAVA ŽA RUČNO ODVAJANJE SVINJSKE KOŽE OD SLANINE I SEČENJE SLANINE, posebno namenjena u domaćinstvu. Pronalazak spada u oblast mesarstva, odnosno instrumenata ili noževa za dranje kože. Rešen je problem konstruisanja ručne naprave kojom, samo izmenom noževa, domaćin može sa kaiševa slanine skinuti kožu (9) od slanine (10), zatim slaninu (10) iseći na komade i iseći suhomesnate i druge prehrambene proizvode. Naprava ima gornju ploču (1) i donju ploču (2) spojene veznom pločom (3) u čijem je žljebu (4) preko zavrtnjeva (5) učvršćen nosač (6) noža (7) za odvajanje kože (9) od slanine (10). Naprava se učvršćuje za sto ili klupu pritezačem (13) a ispred za ploču (3) je zavaren držač (16) sa zavrtnjem (17). Nož (7) je ukošen pod uglom od 45В° u odnosu na radnu ploču (1) i visinski je podešljiv. SuŠtina je u tome da se pod 45В°, na sredini dužine zaseče kaiš slanine i bočno navuče na nož (7). Uz pomoć zabodene viljuškaste alatke (18) koža (9) se odvaja od slavine (10). Okretanjem kaiša slanine isto se uradi i sa drugom polovinom, itd. Prijava sadrži još dve varijante rešenja.
Patent YU-29299-A (YU)
Inventor: YAMINA BONALI
IPC: C07J41/00
Filed: 1997-12-22
Abstract: Pronalazak se odnosi na jedinjenja steroida opšte formule (I) u kojoj n=2,3, ili su R1 i R2 = H, (C1-C4) alkil, ili R1 i R2 formiraju sa atomom azota sa kojim su oni vezani heterociklično jedinjenje, X=OH opcionalno esterifikovano, Y=(C1-C4)alkil, i njihove adicione soli, postupak za njihovo dobijanje, njihovu primenu u medicini i farmaceutske preparate koji ih sadrže.
Patent YU-37594-A (YU)
Inventor: BOURZAT J D
IPC: C07D263/06
Filed: 1994-06-16
Abstract: A method of preparing a taxoid of formula III by esterifying protected baccatin III or deacetylbaccatin III using an oxazolidinecarboxylic acid, or an acid halide, or an acid anhydride thereof.
Patent YU-38593-A (YU)
Title: Uredjaj za opružni pogon pumpe - brizgača
Inventor: STEVAN VEINOVIC
Filed: 1993-06-01
Abstract: UREDJAJ ZA OPRUŽNI POGON PUMPE - BRIZGAČA, prema pronalasku se aktivira igla (2) u pumpi-brizgaču (1) nezavisno od broja obrtaja i opterećenja motora, kako je to inače uslovljeno kod mehaničkog pogona pumpi visokog pritiska. Radnu oprugu (10) sabija jaram (6) koji podižu točkići (8) klizeći po dva simetrično postavljena brega 87) na begastim vratilima (4 i 5), a koja imaju sinhrono okretanje sa radilicom motora. Ceo sistem se drži u kinematskom lancu preko povratne opruge (3), jarma (6), radne opruge (10) i okvira (9). Tvrde pločice (11, 12 i 13) služe za podešavanje statičkih prednapona i garantovanje veka kontaktnih površina.
Patent YU-82792-A (YU)
Title: Novi izosterni peptidi
Inventor: ATRASH B
Filed: 1992-09-08
Abstract: NOVI IZOSTERNI PEPTIDI, pronalazak se odnosi na nove kompetitivne trombinske inhibitore, njihovu sintezu, farmaceutske preparate koji sadrze jedinjenja kao aktivne sastojke, i na koriscenje jedinjenja kao antikoagulanasa za profilaksu i lecenje tromboembolijskih bolesti, prema formuli: u kojoj A pretstavlja -CH2-, -CH=CH-, -CH2-CH2- ili -CH2CH2CH2-; R1 i R2 su isti ili razliciti i svaki pretstavlja H ili X-B-, gde je B alkilenska grupa pravog ili racvastog niza kojia ima 1-3 atoma ugljenika i X je H, metil, etil, cikloalkil grupa koja ima 3-6 atoma ugljenika ili R'CO-, gde je R' OH, alkoksi grupa pravog ili racvastog niza koja ima 1-4 atoma ugljenika, NH2 ili NHR", gde je R" alkil grupa pravog ili racvastog niza koja ima 1-4 atoma ugljenika, ili je X imitatorska grupa karboksilne kiseline, poznata sama po sebi, izabrana od -PO(OR"')2, -SO3-H i 5-(1H)-tetrazolil, i R"' je H, metil ili etil, ili je B -SO2- i X je metil ili etil; m je 0, 1 ili 2, R3 pretstavlja cikloheksil grupu i R3A pretstavlja H; ili m je 1 i R3 pretstavlja cikloheksil ili fenil grupu i R3A je zajedno sa R1 formira etilenski most; Y pretstavlja 0 ili S(O)p, gde je p 0, 1 ili 2; R4 pretstavlja H; alkil ili cikloalkil pravog ili racvastog niza koji ima 1 do 6 atoma ugljenika, nesupstituisan ili supstituisan sa jednim ili vise atoma fluora i/ili supstituisan sa fenil grupom; supstituisan ili nesupstituisan aromaticni prsten izabran od fenil, 4-metoksi-fenil, 4-tercijami-butil-fenil, 4-metil-fenil, 2-, 3- ili 4-trifluorometilfenil, fenil supstituisanog sa 1-5 atoma fluora; ili -CH(CF3)-fenil, ili kao takve ili u obliku fizioloski prihvatljive soli i ukljucujuci stereoizomere.
Patent AT-A118291-A (AT)
IPC: B08B1/02
Filed: 1991-06-12
Abstract: A device for cleaning U-profile sections (2) comprises a brush roll (8), engaging the base of the section from the outside and provided with bristles (14) oriented perpendicularly to the axis of rotation of the roll, and two further brush rolls (4, 5) with bristles (20, 27) forming an acute angle ( alpha ) with the axis of rotation (24, 26) of the brush rolls (4, 5). The brush rolls (4, 5) with bristles (20, 27) inclined in opposite directions with respect to their axes of rotation (24, 26) are arranged in series, based on the direction of movement (arrow 3) of the profiled section (2) through the device.
Patent BE-800284-A (BE)
Title: Indan carboxylic acid derivs compsns - for treatment of allergies
Inventor: GREIG M E
IPC: A61K31/19
Filed: 1973-05-30
Abstract: Allergies, which may or may not be induced by reagin, are prophylactically treated by administration of a cpd. of formula (I): (where Y is cyclohexyl or phenyl; X is H, halogen, CF3, OH, 1-8C alkyl, 1-8C alkoxy, CN, NH2, SH or S-1-8 C alkyl, and R is H, 1-8C alkyl a pharmacologically acceptable cation) in association with a pharmaceutical carrier. (I) are useful in the treatment of bronchitic asthma, allergic rhinitis, food allergies, hay fever, urticaria and auto-immune diseases, and may be administered orally, parenterally or by inhalation, in doses of 5-1000mg. 1-4 times daily.
Patent BE-896049-A (BE)
Title: High pressure sodium vapour lamp - with an increased lifetime and stable arc voltage
IPC: H01J61/22
Filed: 1983-03-01
Abstract: The high pressure sodium vapour lamp has two electrodes in a tube constructed in a material which is highly resistant to heat and transparent to light pref. a ceramic. The tube is filled with a rare gas pref. xinon with Na, Hg and/or Cd as additives at saturated vapour pressure at the temp. of use. The quantity of Hg and/or Cd is calculated as 0.5 to 5 microm. pref. 0.5 to 2.5 microns per cm. length of arc. The lamp functions for longer and during the time of use, the arc voltage stays almost constant without any tendency to extinguish.
Patent BE-898274-A (BE)
Title: Dérivés de la N-halo phosphonométhylamine.
Inventor: SINGH R K
IPC: C07F9/40
Filed: 1983-11-21
Abstract: On décrit des composés de N-halo, N-cyanométhyl, diaryloxyphosphinylméthylamine. Ces composés ont la formule (I), où X est choisi dans le groupe comprenant le brome et le chlore, et les groupementa Ar sont chacun choisis individuellement parmi les groupements consistant en aryles substitués et non-substitués où les substituants sont choisis parmi les radicaux alkyles, alkoxy inférieur et halogène. Ces composés ont une activité herbicide.
Patent BE-899499-A (BE)
Title: Concrete floor esp. for buildings - comprises steel shuttering elements receiving concrete to form composite steel-concrete structure
IPC: E04B5/40
Filed: 1984-04-25
Abstract: The concrete floor comprises a series of cast concrete intersecting beams, the shuttering of which consists of sheets of prefabricated thin steel folded into the desired shape to allow easy installation on site. The shuttering pref. takes the form of tubular members to which other steel members are e.g. welded in order to support the shuttering sections of adjoining beams. - Prior to casting, reinforcing rods are introduced through holes in the shuttering members which on completion hold the beams together. Prefabricated concrete slabs are then placed over the beams before a final layer of concrete is cast to complete the assembly.(0/7)
Patent BE-899820-A (BE)
Title: Dispositif de recolte de vegetaux sur tiges disposes en rangees.
IPC: A01D43/08
Filed: 1984-06-04
Abstract: Ce dispositif de récolte, installé par exemple sur une ensileuse,  comporte des disques trancheurs (17) qui peuvent basculer chacun autour d'un axe de basculement (25) perpendiculaire à l'axe de rotation (24) de ces disques. Les deux disques (17) sont maintenus en contact frottant l'un avec l'autre par l'action d'un ressort (28) agissant sur l'axe de basculement (25). Ainsi, la pression
Patent BE-901603-A (BE)
Title: Isomeres de l'hydroxyvitamine d2.
Inventor: DE LUCA H F
IPC: A61P3/14
Filed: 1985-01-29
Abstract: Nouveaux dérivés de la vitamine D, les isomères de la 25-hydroxyvitamine D2 et de la 1 alpha , 25-dihydroxy-vitamine D2(c) qui comprennent une double liaison en position 23,24. Ces composés se distinguent par une activité vitaminoide D mise en évidence par des épreuves de combinaison compétitive. Ces composés sont donc préférés pour remplacer la vitamine D et certains de ces métabolites dans différentes applications connues, de meme que pour le traitement de maladies osseuses curables par la vitamine D.
Patent BE-760497-A (BE)
Title: Sample dyeing of textile or leather
IPC: D06B23/10
Filed: 1970-12-17
Abstract: A pref. cylindrical dyeing chamber is rotatable about a central diametric axis and fluid is supplied to and air removed from respective diametrically opposed inlets and outlets co-axial with the rotational axis. The inside of the chamber has a gutter which pref. passes through the rotational axis and is inclined at 45 degrees to the horizontal in the two vertical positions of the chamber, so that during each 90 degrees rotation of the chamber fluid flows down the gutter to a fluid outlet surrounding the fluid inlet. The dyeing process can be accurately reproduced, and rotation of the cylinder is continued during the supply of fluid.
Patent BE-778074-A (BE)
Title: Dithionite-contg compsn stabilised by organic surfactant
IPC: D06L4/30
Filed: 1972-01-14
Abstract: Anhydrous compsn. comprising a major amount of a metallic dithionite and a non-polymeric surfactant contg. >=5C and >=1 group of formula O-CO-N in which the uncombined valencies are attached to O, H and C atoms is used as a bleaching agent, reducing agent for dyes and a dye remover in the textile and paper-making industries.
Patent CA-1052813-A (CA)
Inventor: FERNHOLZ HANS
IPC: C07C67/055
Filed: 1974-03-20
Granted: 1979-04-17
Abstract: Abstract of the Disclosure Unsaturated esters of carboxylic acids are prepared by reacting olefins or cycloolefines with carboxylic acids and oxygen in the gaseous phase in the presence of a catalyst containing noble metal salts or noble metals of the VIIIth group of the Periodic System and alcali metal salts and/or alcaline earth metal salts, as activators the content of noble metal being in the range of from 1.2 to 5% by weight and the proportion of the metal fraction of each individual activator to the noble metal content being in the range of from 0.5 to 1 to 3 : 1.
Patent CA-1037807-A (CA)
Inventor: JAMSHIDI KHOSROW
IPC: A61B10/00
Filed: 1974-05-08
Granted: 1978-09-05
Abstract: ABSTRACT OF THE DISCLOSURE            Means for obtaining muscle tissue specimens from a body and comprising a generally cylindrical shaft having a tapered and pointed distal puncturing and cutting tip, and with coaxially disposed sheath means having a sharpened forward cutting edge slidably enveloping the shaft. A sample receiving cavity is formed in the shaft and is provided with a generally sharpened hook in the forward portion of the cavity. The hook has a point directed toward the proximate end of the shaft and comprises an overhanging barb forming a portion of the sample retaining cavity. The sheath is slidable over the shaft between retracted and extended dispositions, with the forward edges of the sheath enclosing the barb when the sheath Is In its forward pre-determined disposition, and with the sharpened tip of the barb being exposed when the sheath is in retracted disposition. The forward sharpened cutting edge of the sheath forms a cutting edge which separates that portion of the sample retained within the sample receiving cavity from the bulk of the tissue, with the separation being in the form of a clean extraction cut. For removal of the sample, simple retraction of the device is possible.