baber/WOPTO huggingface dataset:
Patent AP-1780-A (AP)
Title: Use of cox-2 inhibitors for preventing immunodeficiency.
Inventor: TASKEN KJETIL
IPC: A61K31/5415
Filed: 2001-07-20
Granted: 2007-09-26
Abstract: The present invention provides a method for treating or preventing a disorder typified by an immunodeficiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluophasphaate, L-745337, rofecoxi, NS 398, SC 58125, etodolac, meloxicam, celecoxib flusolide or nimesulide, and compositions and products containing the same or use of the same in preparing medicaments and for treatment.
Patent DO-P2023000111-A (DO)
Title: Derivados de ácido 4-(2-fluoro-4-metoxi-5-3-(((1-metilciclobutil)metil)carbamoil)biciclo[2.2.1]heptan-2-il)carbamoil)fenoxi)-1-metilciclohexano-1-carboxílico y compuestos similares como moduladores de rxfp1 para el tratamiento de insuficiencia cardíaca
Inventor: KENNETH LARS GRANBERG
IPC: A61K31/166
Filed: 2023-06-05
Abstract: La presente invención se refiere a derivados de ácido 4-(2-fluoro-4-metoxi-5-3-(((1- metilciclobutil)metil)carbamoil)biciclo[2.2.1]heptan-2-il)carbamoil)fenoxi)-1-metilciclohexano-1-carboxílico y compuestos similares de formula (I) como moduladores de RXFP1 para el tratamiento de insuficiencia cardíaca, insuficiencia cardíaca con fracción de eyección conservada, insuficiencia cardíaca con fracción de eyección de intervalo medio, insuficiencia cardíaca con fracción de eyección reducida, enfermedad renal crónica y lesión renal aguda. La presente invención también se refiere a formas cristalinas de tales compuestos. Un compuesto a modo de ejemplo es, p. ej., (A).
Patent GB-189706192-A (GB)
Title: Improvements in or relating to Cash Registers, Indicators and Check Printers, or Tills.
Inventor: BOULT ALFRED JULIUS
Filed: 1897-03-09
Granted: 1898-03-05
Abstract: 6192. Boult, A. J., [Rochester Cash Register Co.]. March 9. Platen presses.-Relates to the printing- mechanism of c h e c k tills. At each actuation the apparatus is "set" for indicating and registering the amount by moving fingerplates. A separate fingerplate is provided, say, for cents, dimes, and dollars, and for letters to distinguish the operators, and each carries a series of numbered depressions into the e required one of which the finger is placed and the plate thrust b a c k till the finger strikes a stop-bar. The drawer carries a record strip V<0>, wound between two rollers and passing over a platen V<3> under printing mechanism to be described, and then under a glass plate. The winding-on roller has an attached ratchet-wheel driven in one direction by pawls on a rocking-plate. This plate is rocked by a slip-pawl at each movement of the drawer and returned by a spring. Type-bars C<72>, Fig. 20, carrying duplicate type C<80>, C<81>, are set simultaneously with the indicating- mechanism, being connected therewith by parallel-motion levers and links, and sleeves, levers, and links C<40>, C<52>, C<62>. The type-bars slide in a frame 10 pivoted at 11 which is rocked by cam action, first downwards to print the record strip V<0> on the platen V<3>, and then upwards to print a check on a web X<72> as it passes over the platen 44. Levers 23, 23, pivoted on a sliding bar 27, carry inking- pads 22, 22 at the printing-line, normally raised just above the type. When the type-bars have been set and the actuating-handle of the apparatus is turned, a trigger mechanism is released which allows the bar 27 to be moved to the right by the action of a spring. The pins 23<1>, 23<1> running over a notched guide on the printing-frame, the pads are brought against the type by a spring and are then drawn apart, being finally, after printing has taken place, brought back to normal position. A handset dating-device 53 and a consecutive numbering-mechanism 57 are carried by a rocking frame 52 which is pressed against the web X<72> so as to print on the platen 40 by the return stroke of a vibrating arm 64. The latter receives its movement through a crank and connecting-rod from the actuating- shaft of the apparatus. At each movement of the frame 52, the numbering-mechanism is advanced one unit by the pawl 59. 65 is an inking-pad, which falls on to the face of the dating and numbering wheels whenever the frame 52 drops away from the platens. A roller 66, geared to the main shaft, feeds the check-web X<72> by its raised part 66', gripping it between such raised part and the adjustable feed-roller 68. The raised part may be a printing-plate, inked by a roller 69 and printing the back of the check with any desired matter. As the check strip 72 issues from the machine at X<74>, it is cut off by a pair of shears 70, 71 actuated by the apparatus.
Patent GB-189716576-A (GB)
Title: Combined Stained, Ornamental and Prism Windows.
Inventor: EWEN JOHN MEIGGS
Filed: 1897-07-13
Granted: 1897-09-04
Abstract: 16,576. Ewen, J. M. July 13. Windows.-Prismatic sections J, K are combined with opalescent, mosaic, or stained glass in the same frame in order to increase the illumination and produce an artistic effect.
Patent GB-189720007-A (GB)
Title: Improvements in Fittings for Hose and like Pipes.
Inventor: MCKEE ADAM
Filed: 1897-08-31
Granted: 1897-12-18
Abstract: 20,007. McKee, A. Aug. 31. Couplings, attaching pipes to.-Relates to hose couplings of all kinds, whether for connecting two lengths together, or for attaching nozzles or other fittings, and consists of means for attaching the coupling to the hose. The shank D of the coupling has shoulders F and G, between which lies a strip of metal I, the edges of which come together and form a diagonal joint J as shown in Fig. 2, and which is also perforated so as to set up a number of teeth or barbs K. The end of the shank beyond the collar G is grooved at L, and receives a rubber or other washer M which overlaps the shank, and the diameter of which is greater than that of the collar. On pushing the shank into the hose, it is held there by the teeth K ; the tightness of the joint is ensured by the washer. This mode of attachment also allows a certain amount of swivelling, which prevents the hose from kinking.
Patent GB-189720955-A (GB)
Title: Improvements in the Utilization of Weak Alcoholic Liquids.
Inventor: JOHNSON JAMES EDWARD JOHNSON
Filed: 1897-09-11
Granted: 1898-08-13
Abstract: 20,955. Johnson, J. E. J. Sept. 11. Acetic acid.-Weak alcoholic liquids, such as those produced by mashing and fermenting cereals in the usual manner, are freed from the yeast formed and then converted into dilute acetic acid by oxidation on beechwood chips or shavings in the usual manner, or by passing a current of air through the liquid. The dilute acid solution thus obtained is neutralized with an alkali or alkaline earth, and the corresponding acetate is separated in the solid form by evaporation of the solution The acetate is then acidified with sulphuric acid, hydrochloric acid, or phosphoric acid, and the liberated acetic acid is distilled off and collected.
Patent GB-189723020-A (GB)
Title: An Improved Sounding Apparatus.
Inventor: MUMM DETLEF PETER
Filed: 1897-10-07
Granted: 1897-12-24
Abstract: 23,020. Mumm, D. P. Oct. 7. Sounding - apparatus. - The ordinary sounding- lead is secured in the socket a' by a screw a<2>, and the body a is capable, when the apparatus strikes the bottom, of sliding into the socket b, water escaping by the slots a'. A spring catch b<1> then locks the parts in this position, and the slots are closed so that water cannot enter and disturb the simple taken by the grippers c, c. These grippers are actuated from the body a by the links c<2>, c<2>. If the sea-bed is soft, the grippers c, c take a sample, but if it is hard, the feet b<2>, b<2> hold the instrument up, and the grippers take a sample of any growth there may be on the rocks.
Patent GB-189729209-A (GB)
Title: Improvements in Cycle and other Cranks.
Inventor: WILLIAMSON JOHN TATE
Filed: 1897-12-10
Granted: 1898-11-05
Abstract: 29,209. Williamson, J. T., and Parkinson, T. Dec. 10. Cranks, variable-throw, for bicycles &c. The pedal H is mounted upon a block F fitted to slide on ball bearings on the crank G and coupled to a strap D', D' embracing a fixed eccentric D. The eccentric may have ball bearings ; it is shown fixed to the cycle frame at C<3>, C<4> ; at the other side of the machine it is fixed at the points C', C', so as to clear the chain-wheel A.
Patent GB-189729423-A (GB)
Title: Improved Method of Opening and Closing Carriage Windows.
Inventor: TYLER WALTER HENRY
Filed: 1897-12-13
Granted: 1898-10-22
Abstract: 29,423. Tyler, W. H. Dec. 13. Windows, sliding. Relates to means for raising and lowering the windows. The sash A is supported by a chain K which passes over a pulley H provided with a ratchet-wheel J and pawl P. The pulley H is rotated by its handle to raise the sash, and is released by depressing the lever N when the sash is to be lowered.
Patent GB-189729576-A (GB)
Title: An Improved Separator for use in connection with Granulated Substances, Liquids, and the like.
Inventor: HUET RUDOLPH HENDRIK JOHAN GAL
Filed: 1897-12-14
Granted: 1898-01-22
Abstract: 29,576. Huet, R. H. J. G. Dec. 14. Strainers.- Liquids are strained or separated in the apparatus shown in Fig. 2, the strainer d being held between the cylinder c and ring b which rests on the receptacle a.
Patent GB-189730162-A (GB)
Title: Improvements relating to Cycle Frames.
Inventor: HARFORD HAVELOCK
Filed: 1897-12-21
Granted: 1898-11-19
Abstract: 30,162. Harford, H. Dec. 21. Frames, joints for. The ends of the tubes are compressed to a screw or worm like form so as to engage with the frame lugs. The ends of the horizontal tube B and the diagonal tube are screwed into the seat pillar lug, and the bottom bracket is screwed upon the lower end of the diagonal tube. The bottom tube.D is also screwed into this bracket. The lugs E, F are then screwed upon the tubes B, D, and the steering-socket A is passed through these lugs. The upper end of the socket A has a groove a to receive a projection from the lug E, and the lower end of the socket A and the lug F are correspondingly tapered to form a more effectual connection. The ends of the tubes are cut to the radius of the lugs. A plain tube is inserted within the bottom bracket to lock the concave ends of the tubes entering the bracket. Strengthening-liners may be used. The joints may be soldered or'sweated' together.
Patent GB-189801155-A (GB)
Title: Improvements in and relating to Pneumatic Tyres.
Inventor: BLACK ALEXANDER
Filed: 1898-01-15
Granted: 1898-11-26
Abstract: 1155. Black, A. Jan. 15. Tyres, pneumatic.- Short pieces of sheet metal B, curved to the shape of the rim A, are secured in the outer cover of the tyre by central eyelets C which hook over studs D in the rim. Specification No. 10,990, A.D. 1845, is mentioned in the description.
Patent GB-189801738-A (GB)
Title: Improvements in the Means of Attaching Lamp Gloves, Shades, and the like.
Inventor: BATEMAN FELIX EDWIN
Filed: 1898-01-22
Granted: 1898-12-23
Abstract: 1738. Bateman, F. E. Jan. 22. Lamp-shade, chimney, and globe holders. - A globe, shade, or chimney A for gas, incandescent, electric, and other lamps is attached to a grooved gallery B by means of a spling wire C engaging a groove a. This wire may be secured to the gallery by one or more studs D passing through openings d therein. To release the globe, the outwardlyextending portions c<2> of the overlapping ends of the wire are pressed together, thereby expanding the wire ring. In a modification, the gallery fits within the globe and the ends c<2> of the wire are bent inwards instead of outwards, and the globe is freed by contracting the wire ring. In further modifications, the gallery B is dispensed with, and the wire is connected by arms to a central support.
Patent GB-189802000-A (GB)
Title: A New or Improved Device for Gauging Fingers, Rings, Tubes, and the like.
Inventor: SPOONER ARTHUR FREEMORE
Filed: 1898-01-25
Granted: 1898-04-02
Abstract: 2000. Spooner, A. F., [Delatre, L.]. Jan. 25. G a u g e s.-The instrument is shown as applied to measuring the finger externally and a ring internally, but it is also applicable to gauging tubes and the like. A broad flat spring R is secured at p to the casing B, and at n to a toothed r i n g C which can be rotated in either direction to close the spring on the finger or expand it inside the ring by turning the worm V by the knobs M, M<1>. The worm V gears also with a worm-wheel P the axis of which carries at its ends pointers working over dials marked respectively 'finger' and ring.'
Patent GB-189813109-A (GB)
Title: Improvements in Automatic Scales for Weighing and Measuring Material in Bulk.
Inventor: CLARKE PEETE BASIL
Filed: 1898-06-11
Granted: 1898-09-17
Abstract: 13,109. Clarke, P. B. June 11. Automatic - feed weighers. - An apparatus for weighing coal and the like consists of a bucket 2 moving between roller guides 12 in a casing 1 and balanced by weights 3. Material is fed into the bucket through the flared end 10, and causes it to descend, thereby partially closing the cut-off gates 16 by the rods 17 and springs 21 fixed to the casing. A further descent causes the tripping of the weights 23, hitherto supported by pawls from the side of the casing, and their weight causes the bucket to descend still further, while the closing- gates 7 below are opened by pins 9 and guides 11, thereby allowing the coal to fall freely. The release of the weight causes the bucket to rise and open the gates 16, while the lower gates are closed by the pins and guides referred to above. Pivoted plates 38 are provided for regulating the capacity of the bucket, and modified arrangements of scale gates are described and illustrated.
Patent GB-189814498-A (GB)
Title: Improvements in the Preparation of Sand and like substances to be used in Making Moulds and Cores for Casting.
Inventor: HARGREAVES JOHN
Filed: 1898-07-01
Granted: 1899-05-27
Abstract: 14,498. Hargreaves, J., and Poulson, A. July 1. Casting. - To enable smooth castings to be produced, carbonates and silicates or aluminates of soda or potash are mixed with water and added to the sand or the like to form a gelatinous mass, which may be used both for facing' sand and for cores. Bituminous matter may also be added. The following is a typical composition :-25lbs. of bicarbonate of soda, 40 lbs. of silicate of soda, mixed with 4 tons of sand, and the necessary amount of water added. The powders may be separately dissolved and mixed with the sand.
Patent GB-189815645-A (GB)
Title: Improvements in the Treatment of Refractory Sulphide Ores.
Inventor: ELLERSHAUSEN FRANCIS
Filed: 1898-07-16
Granted: 1899-06-17
Abstract: 15,645. Ellershausen, F. July 16. Metals, extracting.-A. process for smelting refractory sulphide ores containing lead and zinc in an ordinary cupola or blast furnace consists in the use, together with the ordinary blast, of an exhaust sufficiently powerful to prevent any zinc deposits in the furnace. The fan is kept cool and free from accumulation of fumes by playing water upon it. The gases and fumes given off are condensed, collected, and separated by known methods.
Patent GB-189819123-A (GB)
Title: A Process of Treating Potatoes.
Inventor: NEUMANN JOHN GOTTHILF
Filed: 1898-09-08
Granted: 1899-01-07
Abstract: 19,123. Neumann, J. G. Sept. 8. Food preparations.-Potatoes are peeled, cut up, and washed, after which they are soaked in water containing sulphurous acid in the form of sulphite. The soaked potatoes are then washed, partially dried, and plunged into boiling water to rapidly produce a pasty surface. The potatoes are then boiled in several changes of water containing alkali, such as soda, after which they are cooled, then mashed, and allowed to slightly ferment either by themselves or by means of a reagent. The product is now reduced to small pieces in a vermicular or granular form, after which it is baked and desiccated.
Patent GB-189823243-A (GB)
Title: Improvements in and relating to Electric Accumulators.
Inventor: RIBBE PAUL
Filed: 1898-11-04
Granted: 1898-12-17
Abstract: 23,243. Ribbe, P. Nov. 4. Secondary batteries.-The plates or electrodes consist of a frame a, a central plate b, and ribs c inclined upwardly so as to hold the active material in place. The central plate b may be omitted, and the inner faces of each pair of ribs c are united together to form V-shaped grooves.
Patent GB-189904852-A (GB)
Title: Improved Glass and China Drainer.
Inventor: BURY MINNIE
Filed: 1899-03-06
Granted: 1899-06-02
Abstract: 4852. Bury, M. March 6. Drying bottles, jars, cups, &c.-A drainer for glass and china articles consists of a rectangular wooden tray E, of suitable size to stand in a sink, and having an inclined bottom A provided with grooves c, B leading to outlets D.
Patent GB-189911330-A (GB)
Title: Improvements in or relating to Cigar and Cigarette Tubes.
Inventor: CLARK ALFRED
Filed: 1899-05-31
Granted: 1900-01-20
Abstract: 11,330. Clark, A. May 31. Cigar and cigarette holders. - The holder or tube A has a mount B, one portion of which is a divided band C, the two parts of which can be turned on a hinge D to form a rest or support.
Patent GB-189913701-A (GB)
Title: Improvements in Apparatus for Heating Water by Steam.
Inventor: PHILLIPS RUTH EMILY
Filed: 1899-07-03
Granted: 1900-05-05
Abstract: 13,701. Phillips, R. E. July 3. Injectors; combining- tubes.-An injector or apparatus for heating water for lavatory basins, baths, and other purposes by steam is shown in Fig. 1. The steam inlet is formed with the nozzle c, and projects into the coneshaped end e of the tubular portion b, which constitutes the hot-water outlet. The double cone f in the outlet portion b facilitates the mixing of the water from the inlet g and the steam. The steam and cold water supply pipes are as usual furnished with automatic valves.
Patent GB-189915710-A (GB)
Title: Improvements in Water Gauges.
Inventor: GILBERT HENRY K
Filed: 1899-08-01
Granted: 1899-10-21
Abstract: 15,710. Gilbert, H. K. Aug. 1. Gauge-glass fittings.-The object is to protect the upper end of the glass A from being worn and cut away. A rubber ring a, bevelled off at the bottom and having tubular extensions b, b, is fitted over the top of the glass, and rests in the nut C so as to form packing when the tube D is screwed down. Another ring E with extension e is placed on the top of the glass A, and supports a brass tube F so that it reaches down into, but does not quite touch, the glass.
Patent GB-189923510-A (GB)
Title: Improvements in Staircases Constructed Wholly or Partially of Metal.
Filed: 1899-11-25
Granted: 1900-09-29
Abstract: 23,510. Wood & Co., E., and Butler, H. P. Nov. 25. Stairs.-The treads a are formed of pressed steel plates with end flanges b, and projections, - corrugations, or non-slipping upper surfaces. The front edge of the tread may be turned down to form a stair nosing, or it may extend down to the next tread to form a riser. The riser and tread may be formed with an ornamental pattern, and the riser may be cut away so as to produce a partially-open staircase. The flanges b are bolted or riveted to the stringers c, and the risers are bolted or riveted to flanges l of the treads. The flanged treads may be connected by end plates g.
Patent GB-190004221-A (GB)
Title: Hand and Foot Driving Gear for Velocipedes.
Inventor: BOSWORTH JOSEPH
Filed: 1900-03-06
Granted: 1900-12-31
Abstract: 4221. Bosworth, J. March 6. Manumotive velocipedes; driving - mechanism.-A chain-wheel 7, supported in bearings on the top bar 10 of the machine and provided with a handle 11, is embraced by the chain 6 which passes round the wheel 4 on the ordinary crank axle and round the wheel 2 of the driving-wheel. A rope or belt may be used instead of a chain.
Patent GB-190008465-A (GB)
Title: Improvements in or relating to Electric Motors.
Inventor: BOULT ALFRED JULIUS
Filed: 1900-05-08
Granted: 1900-07-14
Abstract: 8465. Boult, A. J., [Collins, P. J.]. May 8. Drawings to Specification. Motor road vehicles.-An electric motor, particularly adapted for use in propelling and steering motor cars, is provided with two armatures, which are geared to two independent driving wheels. The armatures are provided with separate means for regulating their speed, and, when turning corners, are driven at different speeds.
Patent GB-190015045-A (GB)
Title: Improvements in or relating to Incandescent Gas-burners.
Inventor: CLAY WILLIAM RICHARD
Filed: 1900-08-23
Granted: 1901-07-13
Abstract: 15,045. Clay, W. R., and Ennis, C. F. Aug. 23. Incandescent gas lamps. - An anti - vibration burner of the type described in Specifications No. 17,679, A.D. 1897, and No. 27,416, A.D. 1898, is provided with improved sliding rings A, J, burner heads K, K<1>, and bunsen or mixing tubes E. The sliding ring is formed with two flanges A, A' which engage with a single stop C, as in Fig. 2, or a plain sliding ring J engages with two stops or flanges H, H<1>, as in Figs. 9 and 15. The relative positions of the sliding ring and the stop may be reversed, as shown in Figs. 2 and 9, the flanged part, whether the sliding ring A, A' or the stop H, H<1>, is preferably made in two detachable parts, the position of the sliding ring and stop upon the bunsen tube may be varied, and in some cases the stop may be perforated. The burner head, Fig. 9, consists of a central cone K having at its lower end radial arms which are so secured by a flange K<2> on the outer cone K<1> that the gas can escape at P, either between the edges of the flange L and the cone K<1> or through holes in or near the edge of the flange L. The bunsen or mixing tube E is tapered towards its upper end, either by forming a conical bore in a cylindrical tube, as in Fig. 9, or by employing a conical tube E, Fig. 15, with a supplementary cylindrical sleeve E<1> for engagement with the sliding ring J.
Patent GB-190018081-A (GB)
Title: Improvements in Instantaneous Steam Generators.
Inventor: SIMPSON JOHN
Filed: 1900-10-11
Granted: 1901-08-17
Abstract: 18,081. Simpson, J. Oct. 11. Vapour burners. -Instantaneous steam generators for motor cars, preferably consisting of a number of helical coils of tubing side by side, connected together so as to form a continuous conduit for the water and steam, are heated by liquid-fuel burners of the construction shown in Figs. 5 and 6, and fed with water and liquid fuel by pumps. The burner consists of a pipe B formed with several coils, and prolonged beneath the coils at B', where it is perforated for jets of flame B<2>. The flames pass through the coils B, vaporizing the liquid fuel as it passes through them. A bar C is provided which, becoming incandescent, serves to re-ignite any jet which may be extinguished. The feed and oil pumps are placed side by side and their plungers are attached together. They are operated by an eccentric and lever, the fulcrum of the latter being adjustable to adjust the stroke.
Patent GB-190100746-A (GB)
Title: Improvements in Tramway Cars
Inventor: EDGE CHARLES ALLARTON
Filed: 1901-01-11
Granted: 1901-12-14
Abstract: 746. Edge, C. A. Jan. 11. Obstructionremovers; steps; brakes.-In tramcars propelled by cable, or by electric or other motors, the steps are made adjustable, and may be used as obstruction-removers. Fig. 1 shows the step b raised. The adjusting - apparatus comprises three rods c, each having an upper righthand screw passing through a threaded box g secured to the platform and a lower left-hand screw engaging a nut h on the step b. These rods also have pairs of sprocket - wheels e geared by the chains d, the whole being operated by the ratchet lever f or the hand-wheel f<1>. The step carries sleeves m, adapted to slide on the rods l depending from the platform and prevent persons picked up from falling on to the track again, or the space between the platform and step may be filled by lattice or network. The step or fender may be used as an emergency track brake.