baber/WOPTO huggingface dataset:
Patent CR-20220062-A (CR)
Title: Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors
Inventor: HOWARD STEVEN
IPC: C07D487/04
Filed: 2020-08-20
Abstract: The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Patent EC-SP045243-A (EC)
Title: Péptidos macrocíclicos activos contra el virus de la hepatitis C
Inventor: LLINAS-BRUNET MONTSE
IPC: A61K38/00
Filed: 2004-08-20
Abstract: Compuestos de fórmula I, en la que R1 es hidroxi o NHSO2R1A en el que R1A es alquilo (C1-8), cicloalquilo(C3-7) o {alquilo(C1-6)-cicloalquilo(C3-7)}, que están todos ellos sustituidos opcionalmente desde 1 a 3 veces con halo, ciano, nitro, O-alquilo(C1-6), amido, amino o fenilo, o R1A es arilo C6 o C10 que está sustituido opcionalmente desde 1 a 3 veces con halo, ciano, nitro, alquilo(C1-6), O-alquilo(C1-6), amido, amino o fenilo; R2 es cicloalquilo(C5-6) y R3 es ciclopentilo; o una sal farmacéuticamente aceptable de los mismos, útiles como inhibidores de la proteasa N3 del VHC.
Patent EC-SP077316-A (EC)
Title: Compuestos imidazo-3-il-amina bicíclicos sustituidos
Inventor: OBERBOERSCH STEFAN
IPC: C07D471/04
Filed: 2007-03-13
Abstract: La presente invención se relaciona con compuestos imidazo-3-il-amina bicíclicos sustituidos, procedimientos para su preparación, composiciones farmacéuticas que comprenden dichos compuestos y el uso de tales compuestos para la preparación de composiciones farmacéuticas.
Patent EC-SP077321-A (EC)
Title: Procesos e intermediarios para preparar inhibidores de cisteína proteasa
Inventor: LI JIAYAO
IPC: C07D213/32
Filed: 2007-03-15
Abstract: La presente invención tiene como objeto un proceso para preparar determinados inhibidores de cisteína proteasa.
Patent EC-SP099772-A (EC)
Title: Sales novedosas de piperazina como antagonistas d3/d2
Inventor: AGAINE CSONGOR EVA
IPC: A61K31/495
Filed: 2009-11-30
Abstract: La presente invención se refiere a sales novedosas monohidrocloruro, dihidrocloruro, monohidrobromuro, maleato y metanosulfonato de trans 4-{2-[4-(2,3-diclorofenil)-piperazin-1-il]-etil}-N,N-dimetilcarbamoil-ciclohexilamina, y/o sus hidratos y/o solvatos. Además, la invención se refiere al proceso de preparación de sales y sus hidratos y/o solvatos, a su uso en el tratamiento y/o prevención de trastornos que requieren la modulación de receptores de dopamina y a composiciones farmacéuticas que las contienen.
Patent EC-SP951383-A (EC)
Title: Derivados sustituidos 5 de acido micofenolico
Inventor: MORGANS DAVID
IPC: C07D325/00
Filed: 1995-02-16
Abstract: El invento se refiere a los derivados del acido micofenolico, especialmente con una serie de compuestos que tienen cadenas laterales nuevas. La revelada cadena lateral del acido hexenoico, derivada del acido micofenolico son agentes terapéuticos beneficiosos para el tratamiento de los estados de enfermedad indicaos por el acido micofenolico y/o micofenolato mofetil, incluyendo desordenes de inmunidad, inflamatorios, tumorales, proliferativos, vitales o psoriaticos.
Patent EC-SP993137-A (EC)
Title: Miembros de guia deslizables lubricados con grasa que tienen un bajo coeficiente de friccion y un tiempo de vida mejorado
Inventor: GEORGES ETIENNE
IPC: B25D17/26
Filed: 1999-09-13
Abstract: Un dispositivo de guia para miembros mecánicos, que consta de dos partes diseñadas para interactura mediante fricción por deslizamiento, una de las dos partes, llamada la parte lisa, tiene una superficie funcional lisa, es decir de fricción, y la otra parte, llamada la parte perforada, tiene por lo menos una superficie funcional, es decir de fricción que incluye cavidades emergentes diseñadas para acomodar una grasa del tipo de pasta de lubricante y especialmente una grasa EP (grasa de presión extrema) que contiene un constituyente de tipo de jabón, un constituyente de tipo aceite y un aditivo de presión extrema caracterizado porque el ángulo de contacto 0 entre la superficie funcional de la parte lisa y la grasa es entre 20 y 40 grados y porque el material de la parte perforada se escoge de tal manera que el ángulo de contacto entre la superficie funcional de la parte perforada y la grasa es entre 45 y 75 grados, el dispositivo de la invención puede ser del tipo de vía de deslizamiento/superficie de rodamiento, tipo de flecha/cojinete, tipo de articulación de bola/receptáculo, etc.
Patent GB-1050309-A (GB)
IPC: H01F27/26
Abstract: 1,050,309. Transformers. PHILIPS ELECTRONIC & ASSOCIATED INDUSTRIES Ltd. May 17, 1965 [May 20, 19641, No. 20737/65. The U-shaped core parts 1 of a transformer or a choke coil are held together by a metallic clamping band 5, 7, the portions of the band parallel to the direction of compression being subject to tensile stress and the portions at right-angles being subject to bending stress, and the overlapping portions 9 of the band parts 5, 7 being secured together by spot welding. The band 5, 7 may also be spot welded to the core parts 1. A mounting clasp 11 may be spotwelded to the clamping band and an insulating terminal plate 13 may be secured to the clamping band by fastening tongues 17.
Patent GB-1052541-A (GB)
IPC: H01J29/87
Abstract: 1,052,541. Strengthening glassware by coating. PHILIPS ELECTRONIC & ASSOCIATED INDUSTRIES Ltd. March 1, 1966, No. 1901/65. Addition to 976,508. Heading C1M. [Also in Division H1] To strengthen a cathode-ray tube, at least part of the outer surface of the tube is covered with a thin layer of a glaze having a lower coefficient of expansion than that of the glass of the tube, the glaze is then heated superficially for a short time to a temperature at which the glaze becomes mobile, and the tube cooled to give a rough irregularly grooved surface where the glaze was applied. An intermediate layer of a crystallizable glass, of lower coefficient of expansion than the glass of the tube, may be provided. The composition of the glasses are as disclosed in Specifications 971,702 and 976,508.
Patent GB-1053683-A (GB)
IPC: F16J15/36
Abstract: 1,053,683. Mechanical seals. BORGWARNER CORPORATION. June 22, 1965 [June 22, 1964], No. 26424/65. Heading F2B. In a mechanical seal for a rotary pump shaft 57 comprising a sealing washer 25 axially slidable mounted on an annular retainer 11 and having a radial sealing face 29, an elastomeric sleeve 35 with end flanges 37 and 43 engaging an end wall 17 of the retainer and the washer respectively, and a spring 49 compressed between the sleeve flanges 37 and 43 for urging the face 29 against the pump impeller hub, the sleeve 35 has an integral tubular shroud 45 which extends axially over the washer past the sealing face 29. The retainer is fitted within a recess 53 in the housing 55 and has ribs 21 that engage in axial grooves 33 in the washer 25. In a modification, Fig. 3 (not shown), the shroud 45 extends integrally from the flange 37 of the sleeve.
Patent GB-1054789-A (GB)
IPC: G01N30/92
Abstract: 1,054,789. Thin-laver chromatography apparatus. EUROPEAN ATOMIC ENERGY COMMUNITY (EURATOM). Nov. 20. 1963 [Nov. 23, 1962], No. 45867/63. Heading B1X. Thin-layer chromatographic apparatus comprises a carrier 3 in the form of an upright cylinder with a domed upper surface, a thin layer of absorbent thereon and means for feeding element onto the dome. As shown in the Fig. the cylinder is of glass, metal or plastics material, has a depression A to which eluting liquid is supplied, a pointed lower portion and projections B by means of which it is evenly spaced in a throughfeed vessel 2. The latter vessel supports a dropping funnel which maintains a uniform dripping rate independently of its fullness, in ground part 1, and has at its lower end a receiving portion 4 from which fractions are removed by means of a stop-cock. The adsorbent may be applied to the surface of the carrier by spraying.
Patent GB-1225840-A (GB)
IPC: F15C1/10
Filed: 1968-10-18
Abstract: 1,225,840. Fluidic devices. TATEISI ELECTRONICS CO. 18 Oct., 1968 [20 Oct., 1967], No. 49439/68. Heading G4P. [Also in Division G3] A fluidic element comprises a passage for a control stream which controls the deflection of, but does not come into contact with, a main fluid jet. In a bi-stable element, Fig. 1, a jet stream F 1  flows to output ports 11 or 12. Control streams G 1  and G 2  enter input ports 17, 18 and traverse the ends of, but do not enter, passages 19, 20 and exit to ports 21, 22. Openings 25, 26 vent to atmosphere. Stream F 1  flows along passage 9 adherent to the left side thereof (Fig. 3). If control stream G 2  flows it lowers pressure in passage 20 to switch the jet to the output 10. Similarly it may be switched back to its former flow along passage 9 by the presence of control stream G 1 . In a further system (Figs. 5, not shown) the control streams pass from input to output through passages transverse to the passages 19, 20, and lying in the plane of body 1. In a further element (Fig. 9) input ports 57a, 57b, 57c pass control streams to port 59, the streams causing a pressure reduction in passage 54 to switch jet F4. The element acts as an OR/NOR gate. The input ports and control passages may be in a plane perpendicular to that of the body 1, Fig. 15 (not shown). In a further element (Fig. 11) control streams G8, G9 are developed from plural streams entering inlet ports 64a-64c, 65a-65c which are summed in series or parallel to enter passages 66, 67 traversing the ends of spaces 68, 69 to outlet ports 70, 71. The jet stream F5 entering a control region is deflected proportionally to the pressure difference between control streams G8, G9, i.e. to the difference between the number of input streams constituting each. In a further element, Fig. 12, a single control stream G10 developed from two interacting input streams at 75a, b is applied to deflect jet F6 in response to the presence of the two inputs to provide AND/NAND action. In a further element (Fig. 13, not shown) the control streams developed by pairs of interacting input streams interact to develop a main control stream only when all inputs are present, providing AND/NAND operation. In a further element (Fig. 14, not shown) for AND/NAND OR/NOR action in plural stages, a control stream derived from plural inputs as in Fig. 9 and from a plurality of pairs of inputs as in Fig. 13 (not shown) are combined in pairs and plural such pairs are assembled into a set. In a further arrangement (Fig. 16) for OR or NOR action passage 96 is connected to a diaphragm 96 linked to operate a low pressure valve 99 controlling the main jet stream F10. In a further system, Fig. 17, for combined AND/OR action either of control streams G15, G16 impinging on one side of main jet stream F11 deviates it from outlet 108 to 109, while simultaneous flow of control streams G17, G18 operating to reduce pressure on the other side of jet stream F11 similarly deviates it from outlet 108 to 109.
Patent GB-1226619-A (GB)
IPC: F16D47/02
Filed: 1968-08-20
Abstract: 1,226,619. Friction clutches; couplings. FICHTEL & SACHS A.G. 20 Aug., 1968 [23 Aug., 1967], No. 39777/68. Headings F2C and F2U. In a conventional clutch in which a disc 3 is disengaged by pivoted levers 5 and drives a shaft 7, a coaxial shaft 8 is driven by a coupling disc 9 which is bolted to the clutch cover 1. The disc 9 has helical compression springs 10 and peripheral lugs to which nuts 12 are welded. Three bosses 11 project inwards from the cover 1 and screws 13 pass through the bosses into the nuts 12.
Patent GB-1229647-A (GB)
IPC: B23H3/00
Filed: 1968-11-26
Abstract: 1,229,647. Electro-chemical machining apparatus. CINCINNATI MILACRON Inc. Nov.26, 1968 [Nov.29, 1967], No.56120/68. Heading C7B. Apparatus for electro-chemically machining to precise dimensions a previously-formed opening in a workpiece 17 includes a machining tool 12 surrounded by a body member 20, adapted to fit in sealing engagement with the workpiece e.g. by using springs (45), Fig.4 on guide rods (46) bolted to the tool support mechanism (15), the inner surface 22 of which member is circular in crosssection and forms with the tool an electrolyte chamber 25, and means introducing electrolyte tangentially into the chamber, such as four electrolyte inlet tubes in fittings 37, to direct a smooth and uniform flow of electrolyte around the tool (see Fig. 3) and into the space between the tool and workpiece; the electrolyte may then flow into a cavity 31 in the workpiece support fixture 18, out through exit port 32 where it may be cooled, filtered and pumped back. An electrolyte seal 40, e.g. a rubber ring 42 surrounding the tool holder 13, is provided between the body member and tool so as to permit relative movement therebetween.
Patent GB-1230174-A (GB)
IPC: D01F6/18
Filed: 1968-04-24
Abstract: 1,230,174. Acrylic fibres. TORAY INDUSTRIES Inc. 24 April, 1968 [24 April, 1967], No. 19474/68. Heading C3P. Acrylic fibres having a satisfactory wool-like hand comprise (a) at least 85 mol. per cent of structural units derived from acrylonitrile, (b) 2-10 mol. per cent of structural units derived from an unsaturated ester of the formula where R 1  is H or methyl, and R 2  and R 3  represent alkyl groups having 10-18 C atoms, and optionally (c) up to 13 mol. per cent of structural units derived from an additional polymerizable compound; the fibres being characterized by an X-ray diffraction interference intensity ratio defined by: from 0.30 to 0.70. Specified as component (c) are acrylic and methacrylic acids and alkyl (C 1 - C 3 ) esters and amides thereof, styrene and its substituted derivatives, vinyl and vinylidene chloride, vinyl acetate and vinyl benzoate, vinylpyridine and its derivatives, allylsulphonic, vinylsulphonic and styrenesulphonic acids, and salts and esters of such sulphonic acids. The fibres are prepared by heterogeneously polymerizing the monomer precursors of units (a), (b) and, as required, (c), in the presence of a free radical polymerization catalyst, in an organic liquid which dissolves monomeric and polymeric acrylonitrile but is a non-solvent for the monomer precursor of (b), such that the polymerization mixture is heterogeneous throughout the reaction; and spinning the resultant copolymer solution. The copolymers obtained by this heterogeneous procedure are believed to have a block copolymer-type structure. In an alternative procedure, the fibres can be obtained by spinning a mixture of (i) a solution of a homo- or co-polymer of acrylonitrile with (ii) a solution of a copolymer of the above-specified units (a), (b) and, as required, (c) prepared by the heterogeneous procedure described above, the proportions of the monomer constituents in the combined polymeric components of solutions (i) and (ii) being as specified above for the fibres of the invention. Suitable as solvents for the above processes are dimethyl sulphoxide and dimethyl acetamide. Suitable as catalysts are peroxides, redox systems and azonitriles such as azobisisobutyronitrile and azobisdimethylvaleronitrile.
Patent GB-1233771-A (GB)
IPC: D06B3/20
Filed: 1968-03-15
Abstract: 1,233,771. Washing textile webs. VYZKUMNY USTAV ZUSLECHTOVACI. 15 March, 1968 [17 March, 1967], No. 12581/68. Heading D1L. Textile materials 1 are washed as they pass to and fro two sets of vertically stacked rolls, the liquid being applied at the median portion of the width of the fabric and into the wedge created by the ring of the material and the roll; the excess liquid being gathered from the edges of the material and re-directed to the next below median portion. This is done by scoops 4 which may be as described in Specification 1,233,772.
Patent GB-1234504-A (GB)
IPC: G01C19/70
Filed: 1969-02-27
Abstract: 1,234,504. Measuring angles. COMPAGNIE GENERALE D'ELECTRICITE. 27 Feb., 1969 [1 March, 1968], No. 10526/69. Heading G4H. To measure the angle through which a support 3 (Fig. 2) has rotated a plate 2 carried by the support 3 is rotated at a faster speed than the support, each beat pulse derived from a ring- type laser 10 on the plate 2 being counted in a counter 6<SP>1</SP>. For each complete rotation of the plate relative to the support a pulse is fed (from a photo-cell 4 detecting a marker 8) to a multiplier 7 supplying a train of n Î N 2 # pulses, where n is the number of rotations of the plate relative to the support and N 2 # is the number of beat pulses supplied by the laser when the plate rotates through 360 degrees. The pulses from counter 6<SP>1</SP> and multiplier 7 are subtracted to give a pulse train representing the angle through which the support has rotated. The apparatus may be used as a theodolite or in an automatic pilot system.
Patent GB-1239027-A (GB)
IPC: G09C5/00
Filed: 1968-08-21
Abstract: 1,239,027. Coding. LINK MARKETING Ltd. 21 Aug., 1968, No. 39928/68. Heading G5X. A coding device comprises a card 1 in which are a plurality of apertures in vertically spaced rows A, B, C, D, E, both the apertures 2 and 3 and the horizontal spaces between them being preferably equal to, or integral multiples of, a a predetermined unit length. Coding is effected by placing the card on a sheet of paper, preferably squared, or the like, e.g. a wax tablet; writing a message in the apertures, one letter to each unit length thereof; removing the card; and randomly inscribing letters in the blank spaces, so as to give a seemingly unintelligible jumble of letters. Decoding is effected merely be replacing the card in the correct position. Different codes may be achieved by turning the card over or through 180 degrees, the various orientations being indicated by reference marks 4. Non-consecutive reading of the apertures is facilitated by numbering the apertures or providing arrows indicating sequence. A set of colour-coded cards having differently-positioned apertures may be used, and the cards and sheets of paper may be bound together to form a tearoff pad. The cards may be provided as a blank having weakened portions which may be punched out to form the apertures. Such a blank may form a box or carton.
Patent GB-1239711-A (GB)
IPC: D06C7/00
Filed: 1970-01-26
Abstract: 1,239,711. Dyeing process. VEPA A.G. 26 Jan., 1970 [6 Feb., 1969], No. 3738/70. Addition to 1,151,317. Heading D1B. In a patent of addition to specification 1,151,317 which describes a process for the continuous pad-dyeing or printing of endless synthetic filament groups e.g. tows and slivers of synthetic staple fibres, with dyestuffs which are set under the influence of heat, in which process a gas which has been heated to 170- 230‹C is passed, e.g. by means of suction draft, through the filament groups or top slivers which have been printed or padded with the dyestuff and optionally thickeners and other auxiliary agents, steam is used as the heated gas medium.
Patent GB-1250265-A (GB)
IPC: B01J31/00
Filed: 1969-11-07
Abstract: 1,250,265. Process for the manufacture of unsaturated esters of carboxylic acids. KNAPSACK A.G. 7 Nov., 1969 [13 Nov., 1968], No. 54658/69. Heading C2C. A process for the manufacture of unsaturated esters of carboxylic acids by reacting an olefinic compound having from 2 to 20 carbon atoms and an aliphatic or aromatic carboxylic acid having from 2 to 20 carbon atoms with molecular oxygen or air in the gas phase, if desired in the presence of one or more inert gases, at temperatures between 100‹ and 250‹ C., preferably between 150‹ and 220‹ C., under pressures between 1 and 21 atmospheres absolute, preferably between 5 and 11 atmospheres absolute, in contact with a catalyst consisting of metallic palladium, a carrier and optionally a further activator metal, comprises supplying the alkali metalfree catalyst, in a first step and during operation, with one or more alkali metal carboxylates or compounds yielding alkali metal carboxylates under the reaction conditions, the said alkali metal carboxylates or compounds being supplied in the quantity necessary to effect catalyst activation, and, following establishment of an optimum catalyst activity, supplying the alkali metal carboxylate-saturated catalyst, in a second step, with a further quantity of alkali metal compound, the said further quantity of alkali metal compound being normally just sufficient to replace the loss of alkali metal carboxylates occasioned by evaporation from the hot catalyst. Using this process vinyl acetate, vinyl propionate, vinyl isobutyrate and allyl acetate are prepared in the Examples.
Patent GB-1252752-A (GB)
IPC: B42D5/00
Filed: 1968-02-09
Abstract: 1,252,752. Strip indicators. T. W. R. DAVIES. 7 Feb., 1969 [9 Feb., 1968; 23 July, 1968], Nos. 6652/68 and 35079/68. Heading G5C. [Also in Division B6] An index strip holder comprises a base 10, and a holding strip 12 of plastics material secured to the base 10 along one edge thereof, one end of an index strip 20 being held by location between the strip 12 and the base 10, the other end of the index strip being held by second holding means spaced from the holding strip. The second holding means may be a second holding strip, e.g. (16) (Fig. 1, not shown), or may be formed by a cover 16A as shown, secured to the base 10 along the opposite edge thereof. Further holding strips may be located between those along opposite edges of the base 10. A tool for inserting and extracting strips is also described.
Patent GB-1257173-A (GB)
IPC: B01D19/00
Filed: 1968-12-20
Abstract: 1,257,173. Centrifugal separators. PROBST & CLASS MASCHINENFABRIK. 20 Dec., 1968 [20 Dec., 1967], No. 60789/68. Heading B2P. In an apparatus for degrasifying liquids, Fig. 1, the gas-laden liquid is fed via an inlet pipe 8 and a funnel 16 to a centrifuge device 5, 6, 7 from which the liquid is flung as a film on to the inner surface of a holllow rotor 10 where centrifugal force causes separation of the gas from the liquid. The centrifuge device comprises a flat plate 5 carried on a rotatable shaft 3 and provided with radial straight or rearwardly or forwardly curved blades 7 and a frusto-conical cover 6 which is spaced from the plate 5 to form a peripheral gap 9 through which the liquid film emerges. The assembly may be so constructed that the width of the gap is variable. The rotor 10 may be cylindrical or, as shown, frusto-conical. It may be driven by an independent drive which may be variable in speed or, as shown, it may be secured to the cover 6 for rotation therewith. The liquid film flung from the edge of the rotor 10 strikes a stationary cylinder 11 and passes from the latter into the lower part of a container 1 where it is removed through a connection 12. The separated gases are removed through a connection 13 to which a vacuum pump may be connected. In a modification, Fig. 2, the plate 14 and the cover are tapered radially outwardly and the frusto-conical rotor 17 is integral with the cover.
Patent GB-1266437-A (GB)
IPC: E01C5/06
Filed: 1969-08-08
Abstract: 1,266,437. Paving blocks. THAKEHAM TILES (MARKETING) Ltd. 6 Aug., 1970 [8 Aug., 1969], No. 39775/69. Heading E1B. An interlocking surfacing block for roads, playgrounds, runways etc, has opposed generally rectangular wear faces A, (B) which are of constant length and width, the length being substantially twice the width, and corresponding identically sized tongues, 14, 15 and 28 and recesses 11, 12 and 29 in the side and end faces. The blocks are arranged in various ways to provide load bearing surfaces.
Patent GB-1295381-A (GB)
IPC: E02B11/02
Filed: 1970-03-25
Abstract: 1295381 Trench shoring frames A R S MORRICE 19 April 1971 [25 March 1970] 14464/70 Heading E1E A trench shoring frame having relatively horizontally adjustable sections A, B, C adapted to be selectively advanced by rams acting on the back fill, is provided with stabilising fins such as 26, 28, 30 which are adapted to be projected from the side wall or walls to penetrate the wall of the trench in order to resist tilting of the frame during its advance. The frame is also provided with stearing and level control means 62, 64 and with a pivotal hopper 20 for discharging back-soil. For further details such as adjustment means for fins and advancing jacks thereafter to-gether with other stabilising plates, advancing jacks and modus operandi the Specification and remaining drawings (not shown), should be referred to.