Patent SG-11201809687T-A (SG)
Title: Pyridinyl derivatives, pharmaceutical compositions and uses thereof as aoc3 inhibitors
Inventor: BLUM ANDREAS
IPC: C07D417/14
Filed: 2017-05-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111111111111111111111111111111111111111111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/194453 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: CO7D 401/14 (2006.01) CO7D 417/14 (2006.01) CO7D 405/14 (2006.01) A61K 31/506 (2006.01) C07D 413/14 (2006.01) A61P 1/16 (2006.01) C07D 401/04 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: PCT/EP2017/060890 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Declarations under Rule 4.17: 08 May 2017 (08.05.2017) — as to applicant's entitlement to apply for and be granted a (25) Filing Language: English patent (Rule 4.1 7(ii)) (26) Publication Language: English Published: — with international search report (Art. 21(3)) (30) Priority Data: 16169356.9 12 May 2016 (12.05.2016) EP (71) Applicant: BOEHRINGER INGELHEIM INTER- NATIONAL GMBH [DE/DE]; Binger Strasse 173, 55216 INGELHEIM AM RHEIN (DE). (72) Inventors: BLUM, Andreas; Boehringer Ingelheim _ GmbH, Corporate Patents, Binger Strasse 173, 55216 IN- GELHEIM AM RHEIN (DE). GODBOUT, Cedrickx; = Boehringer Ingelheim GmbH, Corporate Patents, Binger Strasse 173, 55216 INGELHEIM AM RHEIN (DE). = _ HEHN, Joerg, P.; Boehringer Ingelheim GmbH, Corpo- rate Patents, Binger Strasse 173, 55216 INGELHEIM AM RHEIN (DE). PETERS, Stefan; Boehringer Ingelheim = _ GmbH, Corporate Patents, Binger Strasse 173, 55216 IN- - GELHEIM AM RHEIN (DE). = (74) Agent: SIMON, Elke et al.; Binger Strasse 173, 55216 IN- GELHEIM AM RHEIN (DE). - (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, = _ AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = — PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, — TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, = 1-1 en (54) Title: PYRIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF AS AOC3 INHIBITORS in 71' (57) : The invention relates to new pyridinyl derivatives of the 71' formula • -:--- ;;, (I) wherein R 1 and A are as defined in the description and claims, 0\ 1-1 H to their use as medicaments, to methods for their therapeutic use and to IN A ,„,, '' N --- ---., ,,„-- 0, ,,,,--N NH 2 (I) pharmaceutical compositions containing them. 1-1 ei R 1.---\" , .. N , - - %- . 0 NH C