baber/WOPTO huggingface dataset:
Patent YU-46030-B (YU)
Inventor: DEXTRAZE P
IPC: C07D477/00
Filed: 1986-11-21
Abstract: POSTUPAK ZA DOBIJANJE KARBAPENEM JEDINJENJA SA KVATERNERIZOVANIM HETEROTIOALKILTIO SUPSTITUENTOM U 2-POLOŽAJU, opšte formule u kojoj je R8 vodonik; R1 je hidroksietil; R15 je vodonik, C1-4alkil ili fenil; R2 je vodonik, anjonski naboj ili karboksi-zaštitna grupa kao što je p-nitrobenzil, pri čemu je, kada R2 predstavlja vodonik ili karboksi-zaštitnu grupu, takodje prisutan i suprotan jon;n ima vrednost 1,2 ili 3; ne supstituisana ili metil-supstituisana diazoli, tiazolil, triazolil, tiadiazolil, tetrazolil, piridil, diazinil, triazinil ili tetrazinil grupa, povezana sa tioalkiltio grupom ugljenikovog atoma u prstenu i kvaternerizovana radikalom R5; i R5 je C1-6alkil grupa; i njihovih farmaceutski prihvatljivih soli, naznačen time, što jedinjenje formule: u kojoj su R1, R8 i R15 kao što je definisano gore i R2 je karboksi-zaštitna grupa kao što je p-nitrobenzil, reaguje u inertnom organskom rsastvaraču kao što je metilen hlorid, acetonitril ili dimetilformamid, u prisustvu baze kao što je diizopropiletilamin, trietilamin ili 4-dimetilaminopiridin i na temperaturi od oko -20 do +40°C, sa približno ekvimolarnom količinom sredstva R0-L, kao što je anhidrid p-toluolsulfonske, p-nitrobenzolsulfonske, 1,4,6-triizopropilbenzolsulfonske, metansulfonske ili trifluorometansulfonske kiseline, difenil hlorofosfat, toluolsulfonil hlorid ili p-bromobenzolsulfonil hlorid, u kome je L odgovarajuća sulfoniloksi ili halogena odlazeća grupa, da bi se dobio intermedijer formule: u kojoj su R1, R8, R15, R2 i L kao što je definisano gore, koji dalje reaguje u inertnom rastvaraču kao što je acetonitril, dimetilformamid, tetrahidrofuran, smeša tetrahidrofurana i vode ili aceton, u prisustvu baze kao što je NaOH, diizopropiletilamin, 1,8-diazabiciklo /5.4.0/undek-7-en, 1,5-diazabiciklo /4.3.0/non-5-en ili tri (C1-4alkil) amin, na temperaturi od -15° C do sobne temperature, sa tiolnim jedinjenjem formule: u kojoj su n i kao što je definisano gore a X0 je suprotan jon, da bi se dobilo jedinjenje formule: gde su R1, R8, R15, R2, n, R5, i X0 kao što je definisano gore; što se zatim, po potrebi, vrši uklanjanje karboksi-zaštitne grupe R2 da bi se dobilo jedinjenje formule (I) u kojoj R2 predstavlja vodonik ili anojnski naboj; i što se dobijeni proizvod, po potrebi, jprevodi u svoju farmaceutski prihvatljivu so.
Patent YU-47063-B (YU)
Inventor: MANIGA A
IPC: C07H15/236
Filed: 1988-11-28
Abstract: In the synthesis of amikacin, having the formula: <CHEM> by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economicity and the synthesis yield to be improved.
Patent ZA-795587-B (ZA)
Title: Convection radiator
Inventor: DAHAN J
IPC: F24H3/04
Filed: 1979-10-19
Abstract: The present invention relates to a novel convection radiator. A convection radiator comprising a system of air circulation by natural convection and a system of air circulation by forced convection including an air convection means, such as a turbine, each of the two air circulation systems comprising a first air circulation passage, a second air circulation passage, and a heating element separating the two passages, wherein the said second passage of the said system of air circulation by natural convection is also the said first passage of the said system of air circulation by forced convection, the warm air outlet of the said system of air circulation by forced convection being located substantially at ground level, a single heating element thus being common to both said air circulation systems.
Patent ZA-805623-B (ZA)
Title: Fungicidal dioxolanyl- and dioxanyl-methazolium derivatives
Inventor: KUNZ W
IPC: A01N43/50
Filed: 1980-09-11
Abstract: The invention provides fungicidal dioxolanyl- and dioxanyl-methazolium derivatives of formula I <CHEM> in which X is -CH= or -N= and Y is the anion of an organic or inorganic acid, and a method for the preparation thereof. These compounds are used in pest control, especially for combatting phytopathogenic fungi.
Patent ZA-818828-B (ZA)
Title: Blowing lance for oxidizing gas, particularly oxygen for the treatment of molten metals
Inventor: SCHAFFAR B
IPC: F27D3/16
Filed: 1981-12-21
Abstract: A lance for blowing an oxydizing gas onto a bath of molten metal, especially for blowing oxygen on a bath of molten pig iron for transforming the same into steel. The lance is provided in an end wall of its nose with at least one central aperture for blowing gas jets at great impulsion onto the bath and a plurality of auxiliary apertures for blowing gas streams of considerably smaller impulsion onto the bath. The auxiliary apertures are constituted by elongated slots through the end wall arranged spaced from each other along a circle at a distance of adjacent edges of the slots and that at least one main aperture of about 2-20 cm. This construction permits to improve the amount of secondary combustion of the reaction gas while prolonging the useful life of the nose of the lance. The lance is advantageously used in conjunction with blowing a stirring gas through the bath of molten metal through refractory gas permeable elements provided in the bottom of a crucible containing the bath.
Patent ZA-826433-B (ZA)
Title: A spring support device for pipework
Inventor: PERRIER JEAN
IPC: F16L3/205
Filed: 1982-09-02
Abstract: A spring support device capable of large vertical displacement for supporting relatively light pipework, such as the purge pipes of a boiler in a power station. The device includes an articulated parallelogram linkage (6) comprising a first hinge (7) connected to a fixed point, a second hinge (8)connected to the load, and vertically opposite the first hinge, and two side hinges (9, 10) in the same horizontal plane. The two arms (11, 13) of the parallelogram linkage that pass through the first hinge have extensions (12, 14) projecting beyond the first hinge and bearing against a plate (3) which transmits force to a compression spring (2). The extensions (12, 14) are considerably shorter than the sides of the parallelogram linkage.
Patent ZA-831633-B (ZA)
Title: New compounds,processes for their preparation and their use as medicaments
Inventor: WEHINGER EGBERT
IPC: A61P25/28
Filed: 1983-03-09
Abstract: Compounds of the formula   <IMAGE>   in which R is an optionally substituted aryl or heterocyclic radical, R1 is a hydrocarbon radical which is optionally interrupted by 1 oxygen atom in the chain, and/or which is optionally substituted, R4 is an aliphatic hydrocarbon radical having 7 to 14 carbon atoms, which is optionally interrupted by one oxygen atom and/or which is optionally substituted, R2 and R3 each independently is hydrogen, an alkyl radical, an aryl radical or an aralkyl radical, or, for the case where one of the substituents R2 or R3 has the above-mentioned meaning, the other is hydroxymethyl, acetoxymethyl or amino, and X is N-R5, wherein R5 is hydrogen, an alkyl radical which is optionally interrupted by an oxygen atom, a morpholinoalkyl radical, an aryl radical or an aralkyl radical or X is an oxygen atom, when one of the radicals R2 or R3 denotes an amino group, or pharmaceutically acceptable acid addition salts thereof, exhibit hypotensive activity.
Patent ZA-842785-B (ZA)
Title: Novel reinforced fluoropolymer composite and method for making same
Inventor: EFFENBERGER JOHN A
IPC: C09D127/12
Filed: 1984-04-13
Abstract: A novel composite comprises a substrate having a coating matrix including an initial layer of a perfluoropolymer and an overcoat comprising a fluoroelastomer, a fluoroplastic, a fluoroelastomer/fluoroplastic blend, or a combination thereof. The perfluoropolymer in the initial layer may be a perfluoroplastic, a perfluoroelastomer, or blends thereof. In a separate embodiment, the novel composite includes a substrate coated solely with one or more layers of perfluoroelastomer alone or as a blend with a perfluoroplastic. Where the substrate is not susceptible to hydrogen fluoride corrosion, the composite may include solely one or more layers of a blend of a fluoroelastomer and a hydrogen-containing perfluoroplastic. Cross-linking accelerators may be used to cross-link one or more of the resins contained in the coating layers. Each composite may be topcoated with the layer or layers of a fluoroplastic, fluoroelastomer, and/or a blend thereof. The composite is flexible, exhibits good matrix cohesion and possesses substantial adhesion of the matrix to the material acting as the reinforcement or substrate. A method for making such a composite comprises the unique deployment of a perfluoropolymer directly onto the substrate in a relatively small amount sufficient to protect the substrate from chemical corrosion without impairing flexibility, followed by the application of the overcoat layer.
Patent ZA-869065-B (ZA)
Title: Novel catalyst systems for the preparation of foams containing isocyanurate and urethane linkages
Inventor: ELING BEREND
IPC: C08G18/18
Filed: 1986-12-01
Abstract: The invention relates to the preparation of polymer foams containing urethane and isocyanurate linkages by the use of a catalyst system based on an alkali metal or tetraalkylammonium carboxylate and a group IIa metal carboxylate.
Patent ZA-882657-B (ZA)
Title: Thiadiazole guanidines
IPC: C07D285/135
Filed: 1988-04-15
Abstract: Thiadiazole guanidines of formula 1 <CHEM>  wherein R is hydrogen or C1-4 alkyl and their non-toxic salts. Processes for their preparation and pharmaceutical compositions thereof. The compounds exhibit anti-convulsant activity and are indicated for use in the treatment of epilepsy.
Patent ZA-903345-B (ZA)
Title: Induction furnace for heating and temperature homogenization in hot-rolling of thin steel strips
Inventor: ARVEDI GIOVANNI
IPC: H05B6/10
Filed: 1990-05-02
Abstract: PCT No. PCT/IT90/00053 Sec. 371 Date Mar. 14, 1991 Sec. 102(e) Date Mar. 14, 1991 PCT Filed May 17, 1990 PCT Pub. No. WO90/14742 PCT Pub. Date Nov. 29, 1990.An induction furnace is described which is capable to heat a thin strip from a continuous casting apparatus throughout the furnace itself after a previous rolling, at a homogeneous temperature adapted to the subsequent rolling steps. The induction furnace of the present invention comprises, in a known manner, an array of toroidal coils being fed at M.F., with intermediate feeding rollers having reduced size along the strip feed direction with respect to the known coils so that the rollers are less spaced from each other. Flux concentrators are also provided, being distributed preferably in pairs on the inductor and mounted transversely movable with respect to the strip forward movement and possibly also in a plane perpendicular thereto.
Patent ZA-912824-B (ZA)
Title: Sheet material
Inventor: MCKINNON ROBIN
IPC: B29D24/00
Filed: 1991-04-16
Abstract: PCT No. PCT/GB91/00583 Sec. 371 Date Dec. 17, 1992 Sec. 102(e) Date Dec. 17, 1992 PCT Filed Apr. 12, 1991 PCT Pub. No. WO91/16243 PCT Pub. Date Oct. 31, 1991.A plastic sheet material comprising a pair of opposed faces between which run a series of elongate voids, the voids being arranged such that there are a series of uninterrupted interconnections between the two opposite faces. The voids are of a cross-sectional shape such that there is a substantial absence of sharp corners. Where the voids are not in themselves round, the corners are radiussed. In a preferred construction, two series of interconnections are provided which join one another where they meet. The construction is particularly useful in packaging, especially the packaging of food products. The present invention has high buckling resistance in both the machine and cross-machine directions and is particularly resistant to torsional stresses, compression and/or extension and demonstrates good impact resistance.
Patent ZA-913092-B (ZA)
Title: Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines
Inventor: DEAN WILLIAM DENNIS
IPC: C07D409/14
Filed: 1991-04-24
Abstract: The invention provides a novel process for producing N-[3-(1H-imidazol-1-yl-4-(substituted-2-pyrimidinamine compounds in which the substituent is a 2-pyridinyl, 3-pyrindinyl, 4-pyridinyl, 2-furanyl or 2-thienyl group. The process includes the steps of (1) reacting a 3-(1H-imidazol-1-yl)benzamine with cyanamide and a halogen acid while controlling the pH of the reaction between pH about 2 to about 3.5 and recovering a [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide and (2) reacting the [3-(1H-imidazol-1-yl)phenyl] quanidine dihydrohalide so recovered with an appropriately substituted 3-dimethylamino-1-(substituted)-2-propen-1-one and a base at a pH of from about 10.5 to about 11.5 and recovering the N-[3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidamine compound so produced. The novel process provides improved yield and purity by adhering to the stated crucial pH ranges.
Patent ZA-931444-B (ZA)
Title: Pulsatile once-a-day-delivery systems for minocycline
Inventor: SHETH NITIN VADILAL
IPC: A61K9/50
Filed: 1993-03-01
Abstract: Pharmaceutical delivery systems containing 7-dimethyl 6-deoxy 6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of less than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.
Patent ZA-936925-B (ZA)
Title: Modified platelet factor-4.
Inventor: GUPTA SHALLEY KANT
IPC: C12R1/91
Filed: 1993-09-20
Abstract: The present invention is based of the discovery of two modified forms of human platelet factor-4, herein named MPF-4 and CPF-4, which were isolated from serum free culture medium of lipopolysaccharide-stimulated peripheral blood leukocytes. Amino acid sequence determination revealed that MPF-4 shares homology with platelet factor-4 beginning at N-terminal residue 17. CPF-4 consists of MPF-4 disulfide bonded to the 16 N-terminal residues of platelet factor-4. Both MPF-4 and CPF-4 are potent inhibitors of endothelial cell proliferation, approximately 10-100 fold more potent than native or recombinant platelet factor-4, making them useful in the treatment of angiogenic diseases.
Patent ZA-938999-B (ZA)
Title: Modular unit and method for producing seats
Inventor: GIOCCHINI NILO
IPC: A47C3/00
Filed: 1993-12-02
Abstract: A modular unit (1) for assembling seats comprises a plurality of elements (2) which are spatially complementary and can be grouped together about an axis (X-X). The elements (2) can be associated with respective portions of the seat to be produced and are rigidly connected together by means of a screw (14) which can extend through a longitudinal hole formed jointly by the grooves (5) in the elements (2). The rotation of the screw (14) causes a transverse sliding of two locking elements (10, 15) having inclined surfaces (16) which cooperate with respective sloped portions (8) of the elements (2) in order to urge the elements (2) into the state in which they are assembled about the axis (X-X). <IMAGE>
Patent ZA-939604-B (ZA)
Title: Imidazole derivatives
Inventor: SZCZEPANSKI HENRY
IPC: C07D401/12
Filed: 1993-12-22
Abstract: Compounds of the formula <CHEM> in which R1, R2, R3, R4, Y and Z are as defined in claim 1, and, if appropriate, the tautomers thereof, in each case in free form or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
Patent ZA-942531-B (ZA)
Title: Device for rapidly changing and maintaining a lateral wall of a machine for the continuous casting of a metal product between rolls
Inventor: LEGRAND HUGUES
IPC: B22D11/06
Filed: 1994-04-13
Abstract: The continuous casting machine includes two contra-rotating rolls (1, 2) with parallel axes arranged opposite each other, with a certain spacing, and on the axial ends of which two side walls (5a) bear so as to define a casting space (3) between the rolls. The device for rapidly changing the side wall (5a) includes a small barrel (14) comprising fastening means (16) for at least two side walls (5) in positions resulting from one another by means of a rotation through a specific angle about the axis of the small barrel. Means for rotationally displacing the small barrel in steps having an amplitude corresponding to the specific angle of rotation make it possible to displace a replacement side wall (5b) from a standby position to a position occupied by the active side wall (5a) to be replaced. <IMAGE>
Patent ZA-956083-B (ZA)
Title: Modular connector with separable wire retention
Inventor: MATTHEWS GARY
IPC: H01R13/514
Filed: 1995-07-20
Abstract: A modular, multiple-wire connector has a connector body (10) with insulation displacement contacts (18) or twisted plug contacts to allow the modular interconnection of a plurality of wires, particularly pairs of telecommunications wires, and further includes a cover which is releasable from the connector body to expose the terminal portions of a first set of the wires at their connection points, and a wire retention strip (40) which is separably attached to the connector body along an edge thereof. Variations of the connector body (10) and wire retention strip (40) are disclosed, and several similar or different strips may be used on a single connector body. The wire retention strip (40) may have two rows of wire retention posts (44) along both edges thereof, and the connector body (10) may be designed to receive two such strips (40), one on either side thereof.
Patent ZA-971233-B (ZA)
Title: Method of producing a non-flammable shaped part in particular a building-material panel
Inventor: TOMANDL ERWIN
IPC: B28B23/00
Filed: 1997-02-13
Abstract: A process is proposed for producing non-combustible moulded articles from blown vermiculite, the blown vermiculite granules being mixed with an inorganic binder and then pressed. The blown vermiculite granules are mixed with a solution of an inorganic binder, the vermiculite granules once mixed are pre-pressed, cut to the shape required and the cut blanks are pressed non-continuously at at least room temperature and preferably at temperatures of at least 100° C. and pressures of at least 0.3 N/mm2 to ensure that all solvent residues are removed from the finished non-combustible moulded article.
Patent ZA-972682-B (ZA)
Title: Drum for dispensing wipe material in a dispensing apparatus with adjustment of the format length of material delivered.
Inventor: GRANGER MAURICE
IPC: A47K10/36
Filed: 1997-03-27
Abstract: A drum for dispensing a wiping material in a dispensing apparatus, including a cutting device (5) and coacting with a pressure element (6) so that the sheet of material to be cut may be inserted therebetween. The drum and the pressure element are built into the housing of the dispensing apparatus, and one 360 DEG  rotation of the drum enables a length of material to be dispensed. The drum (4) contains means enabling adjustment as programmed by a mechanism (24, 25) for selecting the length of sheet material to be dispensed on the basis of minimum and maximum values and a differential amplitude.
Patent ZA-972729-B (ZA)
Title: Method of obtaining pure enantiomers of a pyridazinone derivative.
Inventor: TIMMERBACKA MIKA
IPC: C07B57/00
Filed: 1997-03-27
Abstract: The invention provides a novel, crystalline polymorphic form of (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile and a method for making the polymorph. The compound is useful as a cardiotonic agent.
Patent ZA-974416-B (ZA)
Title: Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use.
Inventor: WAGNER ADALBERT
IPC: C07D277/62
Filed: 1997-05-21
Abstract: Sulphur-containing bradykinin antagonist compounds of formula (I) and their salts are claimed: one of X1-X3 = COR<2>, and the other X1-X4 = N, CR<1>; R<1>,R<3> = H, halo, 1-6C alkyl, OR<6>, SR<6>, NHR<6>, 6-12C aryl, (6-12C aryl)(1-3C alkyl), C(O)OR<6>, C(O)H, 2-5C alkenyl, NO2, SO3R<7>, CN, C(O)NHR<8>, where alkyl, aryl, alkenyl may be substituted by C(O)(O)o(1-5C alkyl), OR<6>, SR<7>, NO2, CN, NHR<8>, halo; R<2> = (II); R<4>,R<5> = e.g. H; R<6>-R<8> = H, 1-5C alkyl, 3-5C alkenyl, etc.; A = amino acid e.g. methionine, alanine, phenylalanine, etc.; R<9> = H, C(O)(O)o(1-5C alkyl), C(O)(O)o(11-3C alkyl)(6-10C aryl); R<10> = e.g. C(O)DE; D = 2-5C alkendiyl, 1-8C alkandiyl, (CH2)nYo(CH2)m, etc., where any of the groups are optionally substituted by e.g. OR<6>; E = H, 6-10C aryl, 1-9C heteroaryl, etc.;Y = O, S, NR<8>; n,m = 0-6; o = 0 or 1.
Patent ZA-985542-B (ZA)
Title: Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
Inventor: BONDINELL WILLIAM E
IPC: A61K31/454
Filed: 1998-06-25
Abstract: This invention relates to substituted benzanilides which are ligands, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted benzanilides which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor ligands may be useful in the treatment of HIV infection.
Patent GB-2380384-B (GB)
Title: Rig tester device
Inventor: WOODFIELD PAUL BENEDICT
IPC: A01K97/00
Filed: 2001-10-02
Granted: 2004-12-29
Abstract: The device consists of a hand operable bulb pump (3) attached at one end of a throat section (2). At the other end is a mouth section (1) shaped to mimic the mouth of a fish. The device enables anglers to test underwater the hooking qualities of a fishing rig, which comprises line, hook, bait and/or lure. In use the squeezing of the bulb causes water to flow in and out of the mouth section simulating the feeding actions of a fish. The mouth section may have movable parts.
Patent GB-2388262-B (GB)
Title: An intelligent serial battery charger and charging block
Inventor: YAU KWOK WONG
IPC: C07J75/00
Filed: 2002-09-02
Granted: 2005-05-04
Abstract: A bypassing switch (413,423,433,443) has a very low impedance when turned-on and a very high impedance when turned-off. A one-way electronic device is characterized in that it has very low-impedance when current flows from the charging section into the battery terminals and it has a high-impedance when the bypassing switch is turned on. An independent claim is included for: (a) a charging block for use in a serial battery charger including at least first and second parallel- connected branches.