baber/WOPTO huggingface dataset:
Patent IL-155128-A0 (IL)
Title: Dynamic resolution of isomes and resolved isomers
IPC: C07K1/06
Filed: 2001-09-24
Abstract: Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution is with a leaving group and wherein the alpha carbon is chiral, with a homochiral amine to form a salt that is partially insoluble under selected reaction conditions, wherein the homochiral amine is selected so that the solubility of the amine salt of the undesired alpha-substituted carboxylic acid is greater than that of the amine salt of the desired alpha-substituted carboxylic acid under the selected reaction conditions; (b) reacting under the selected reaction conditions the salt with a nucleophile, wherein the reacting is effective in producing a net increase in the less soluble amine salt of the alpha-substituted carboxylic acid, and wherein the selected conditions are selected to (i) promote nucleophilic substitution of the nucleophile and the leaving group or (ii) to produce the increase in the less soluble amine salt in the absence of a strong base; and (c) maintaining the reaction for a period of time effective to increase the amount of the desired alpha-substituted carboxylic acid isomer.
Patent IL-166761-A0 (IL)
Title: Use of CGRP antagonist compounds for treatment of psoriasis
IPC: A61K31/727
Filed: 2005-02-08
Abstract: A method for treating, remedying, or preventing inflammatory skin disorders by administering a therapeutically effective dose of at least one an antagonist of a calcitonin gene-related peptide receptor in a pharmaceutically acceptable formulation. The method for treating, remedying, or preventing an inflammatory skin disorder by administering topically and to the prepsoriatic rim a therapeutically effective dose of at least one an antagonist of a calcitonin gene-related peptide receptor in a pharmaceutically acceptable formulation.
Patent IL-207673-A0 (IL)
Title: Method for the synthesis of a bifunctional complex
IPC: C12N15/10
Filed: 2010-08-18
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part wherein a nascent bifunctional complex comprising a chemical reaction site and priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site using one or more enzymes.
Patent ZW-2987-A1 (ZW)
Title: Continuous stationery
Inventor: FRED VAN VLIET
IPC: B42D15/00
Filed: 1987-02-16
Abstract: Continuous stationery (1) to be typed upon or printed with characters by a print unit of a computer or the like having a plurality of blocks (4) extending transversely across the continuous stationery, the blocks having a depth of one eighth of an inch with the blocks spaced at a distance apart of one half of an inch (l2.7 millimetres).
Patent LU-85747-A1 (LU)
Inventor: CALDERON PIEDAD
IPC: C07D233/58
Filed: 1985-01-28
Abstract: Derivatives of imidezole corresponding to formula I 
<CHEM>
 wherein X<1>, X<2>, Y<1> and Y<2>, whether or not identical can have different significancies, R<1> is hydrogen, a methyl or phenyl group, R<2> and R<3>, whether or not identical represent hydrogen, a hydroxyl, alkyl or alkoxy group, it being possible for R<1> and R<2> together to represent a carbon-carbon bond, R<4> and R<5>, whether or not identical, being hydrogen or alkyl, and the tautomers and salts of these compounds, also the pharmaceutical compositions containing them. 
<??>The compounds are endowed with  alpha 2-blocking and/or anti-convulsive activities and are utilisable as therapeutic agents for man.
Patent LU-87644-A1 (LU)
Inventor: RENE LARGUIER
IPC: B60L50/10
Filed: 1989-12-19
Abstract: The power unit for a vehicle includes a thermal engine (1) and an electric motor (2). At low speed, the electric motor (2) has a driving torque higher than the thermal engine's (1) load moment. The electric motor (2) is designed to operate without being mechanically disconnected from the thermal engine (1) when the latter is running at its operating speed. In particular, the electric motor makes it possible to replace the starting motor, the alternator, and the flywheel of the thermal engine, and to provide additional or independent propulsion.
Patent MA-38143-A1 (MA)
Title: Composition comprenant des agents de lutte biologique
Inventor: ANDERSCH WOLFRAM
IPC: A01N63/30
Filed: 2015-06-01
Abstract: La présente invention concerne une composition comprenant au moins un agent de lutte biologique choisi dans le groupe consistant en souche 251 de
Patent MA-48425-A1 (MA)
Title: Fabrication continue de conjugues de medicament a molécule de guidage
Inventor: PAULSEN HOLGER
IPC: B01J19/24
Filed: 2018-07-12
Abstract: L'invention concerne une unité de modification (37) pour le traitement continu et à réduction des agents pathogènes d'une molécule de guidage, par exemple un conjugué d'un peptide ou d'une protéine ou d'un acide nucléique et d'un lieur comprenant les composants suivants : au moins un réservoir contenant la molécule de guidage dans une solution tampon (1) et/ou au moins une entrée pour un flux de produit contenant la molécule de guidage dans une solution tampon, au moins un réservoir contenant le lieur en solution (2), au moins un dispositif de mélange (3), au moins deux vannes (7, 8), l'une pour le dosage de la molécule de guidage et l'une pour le dosage de la molécule de liaison, au moins une sortie pour le flux de produit comprenant les complexes molécule de guidage-lieur et/ou un réservoir pour la prise des complexes molécule de guidage-lieur (5) comprenant en outre au moins un dispositif de temps de séjour assurant un temps de séjour défini, c'est-à-dire assurant qu'après mélange des molécules de guidage et que les molécules de liaison passent toujours une quantité de temps similaire dans un processus continu.
Patent MA-57094-A1 (MA)
Title: Dispositif médical intelligent de mesure d'elasticité de la peau snidem (smart non-invasive medical device for skin ealsticitymeasure)
Inventor: FAOUSSI MOHAMED
IPC: A61B5/00
Filed: 2022-06-16
Abstract: Dispositif médical pour garantir une meilleure précision de mesure des paramètres mécaniques de la peau humaine, notamment son l’élasticité. L’objectif est d’éviter le maximum possible une mauvaise interprétation de l’élasticité de la peau à cause des méthodes actuelles de calcul de ce paramètre mécanique. Ces techniques consistent à : - la rotation de la peau et la mesure du temps de revient à son état initial ; - l’aspiration de la peau et la mesure de la profondeur de la peau aspirée. A contrario, notre dispositif doté d’un système intelligent, permet de détecter les directions privilégiées des fibres de collagène. Il permet aussi de faire un calcul mathématique de régression linéaire pour définir la droite moyenne, selon laquelle les tests d’étirement mécanique sont assurés. L’objectif est de calculer l’élasticité cutanée avec une excellente précision.
Patent UY-31485-A1 (UY)
Title: Método para identificacion de prolificidad en mamiferos, molécula de adn mutado, polipéptido codificado por la misma y equipo para deteccion e identificacion de animales superiores
Inventor: SOUZA CARLOS JOSE HOFF DE
IPC: C07K14/47
Filed: 2008-11-24
Abstract: La presente invencion se refiere a un método de prevision de prolificidad en mamíferos, por medio de análisis de marcador molecular específico para una nueva mutacion correlacionada con el aumento de la tasa de ovulacion. La identificacion correcta y simple de la presencia de mutacion, proporcionada por el uso del método, puede ser de gran efectividad en el mejoramiento genético de ovinos, así como en el manejo reproductivo del rebano. La invencion también se refiere a una nueva mutacion del gen GDF-9 que altera positivamente la tasa de ovulacion y al uso de dicha secuencia génica para la produccion de animales transgénicos de alta prolificidad.
Patent ES-151114-A1 (ES)
Title: UN PROCEDIMIENTO PARA IMPEDIR LA FORMACIoN DE VAPOR DE GAS LiQUIDO
IPC: F02M21/00
Filed: 1940-12-14
Abstract: La propiedad y explotación exclusivas de un procedimiento para impedir la formación de vapor de gas líquidoespecialmente durante el calentamiento en la bomba de inyección de combustible de los motores de explosióncaracterizado por alimentarse el gas líquido a la bomba de inyección bajo una presión tan elevada ypor lo tantode un punto de ebullición tal elevado que no puede ya hervir en la bomba de inyección.
Patent ES-177739-A1 (ES)
Title: Un receptor superregenerativo para senales de onda moduladas en frecuencia o fase
Filed: 1947-04-23
Abstract: Procedimiento de fundición de cobre que incluye un proceso para fundir matas ricas de cobre del tipo en que una carga de mata en estado de fusión se insufla con aire en un horno caracterizado por el hecho de elevarse la temperatura de la carga de mata introduciendo combustible carbonoso o gaseoso en el horno y quemándolo para producir una temperatura más elevada y una disminución del contenido de bismuto de la carga de mata por debajo del nivel que puede conseguirse insuflando sin combustible.
Patent ES-178076-A1 (ES)
Title: Mejoras en o relativas a tubos de descarga electronica
IPC: H01J21/06
Filed: 1947-05-17
Abstract: Tubo de descarga electrónica que comprende un disco pantalla de metal sellado a la ampolla de modo que los lados de entrada y salida del tubo están eficazmente pantalleados como se describe en la solicitud de patente británica número 7.495/41 y en la correspondiente española número 175.959. caracterizado en que la rejilla está conectada mecánicamente al disco pantalla para proveer un contacto eléctrico íntimo con la misma con lo que el circuito de corriente desde el centro de los alambres de rejilla al disco pantalla es tan corto y directo como es posible.
Patent ES-181088-A1 (ES)
Title: Un generador de impulsos
Filed: 1947-12-23
Abstract: Un generador de impulso, caracterizado por la combinación de un transistor y un circuito de gobierno de constancia de frecuencia alta.
Patent ES-187658-A1 (ES)
Title: PERFECCIONAMIENTOS EN Y RELATIVOS A LA GENERACIoN DE UNA CORRIENTE ELÉCTRICA INTERMITENTE
IPC: G01S7/52
Filed: 1949-03-31
Abstract: Perfeccionamientos en y relativos a la generación de una corriente eléctrica intermitente comprendiendo un inductor y un condensador conectados o conectables en paralelo terminales para la conexión de un manantial de corriente contínua para producir flujo de corriente en el inductor y para cargar el condensador y un dispositivo conmutador para conectar alternativamente el condensador entre los terminales y para un circuito de trabajo caracterizados por un dispositivo para evitar la descarga del condensador a través del inductor después de que el voltaje que atraviesa el condensador ha alcanzado un valor máximo.
Patent ES-188363-A1 (ES)
Title: MEJORAS EN SISTEMAS TELEFoNICOS
Filed: 1949-05-24
Abstract: En un sistema telefónico automático; varias líneas de abonado; varias centrales telefónicas de las cuales una por lo menos es una central del tipo paso a paso que comprende selectores paso a paso; una central que llama comprendiendo selectores movidos por energía y registradores para establecer conexiones a líneas locales de abonado; estando los registradores equipados con detectores electrónicos y relés registradores para registrar el número de una llamada marcado por un abonado que llama; medios en el registrador para establecer conexiones a través de los selectores movidos por energía bajo el control del detector electrónico a líneas de abonado locales; un circuito pulsador; medios para conectar el circuito pulsador a un registrador cuando el número de la llamada registrado designa una línea llamada en una central paso a paso; medios en el circuito pulsador para accionar los selectores paso a paso; suministros de diferentes potenciales; medios en el registrador para aplicar potenciales al detector electrónico que caracterizan la selección correspondiente al número de la llamada registrado en los relés registradores; medios en el circuito pulsador para aplicar potenciales al detector electrónico que caracterizan el número de impulsos transmitido a los selectores paso a paso; y medios para detener los impulsos cuando dicho potencial aplicado a dicho detector electrónico por dicho circuito pulsador tiene una relación predeterminada con dicho potencial aplicado a dicho detector por dichos relés registradores.
Patent ES-189638-A1 (ES)
Title: Un dispositivo para engendrar, amplificar o modular ondas decimétricas
Filed: 1949-09-06
Abstract: Válvula de descarga electrónica en la cual un haz electrónico es desviado por la interacción de una onda que se desplaza caracterizada por el hecho de que el haz electrónico emana de un electrodo cilindrico que está rodeado por una o más grillas de comando o grillas pantalla mientras que los electrodos desviadores a lo largo de los cuales se mueve la onda que se desplaza son hechos de dos espirales planas que rodean al sistema de electrodo mencionado en primer término o de una espiral plana que es provista en oposición a una placa conductora plana.
Patent ES-254428-A1 (ES)
Title: Water-soluble salts of anthraquinone dyestuffs and process for their manufacture
IPC: C09B1/00
Filed: 1959-12-23
Abstract: The invention comprises water-soluble salts of dyestuffs which contain a single anthraquinone nucleus, are free from acid water-solubilising groups and have attached to the anthraquinone nucleus at least one group of the formula:-NH-R-NHCOA-Q where R is alkylene or phenylene, A is alkylene which may be substituted by aryl and which may be interrupted by an amino group and Q is a salt of a tertiary or quaternary ammonium group and an acid. The dyestuffs are made by acylating an appropriate anthraquinone which contains at least one group of the formula: -NH-R-NH2 with a halide of an aliphatic monocarboxylic acid which contains a tertiary or quaternary ammonium group or a halogen atom in a - or b -position to the carboxylic acid halide group, and in the latter case condensing the product with a secondary or tertiary amine or with an alkylene diamine having one tertiary and one primary or secondary amino group and, if desired, treating the product with an alkylating agent. Examples are given. The salts dye tanned cellulose fibres, silk hair or fibres of asymmetrical dicyanethylene polymers or of polyacryolnitrile or polyesters in a variety of shades.
Patent ES-334488-A1 (ES)
Title: Device for filling sterile liquids,especially carbon dioxide containing beverages,into sterile bottles made of synthetic material
IPC: B67C7/00
Filed: 1966-12-13
Abstract: Sterile liquid, e.g. an effervescent beverage, is bottled by apparatus comprising a plant 3 to produce plastics &c. bottles, a pneumatic conveyer 9, and a bottle filling and capping machine 11, the filled bottles then being put into cartons 26. The bottles, produced at a high temperature and therefore sterile, are moved by sterilized suction or compressed air along the conveyer 9. The bottles may be rinsed in sterilized air, carbon dioxide or nitrogen before and/or after conveying but before filling, using a rinsing station 6, detailed in Fig. 3, supplied with suction at 21, low pressure gas at 24, and compressed gas at 19 to eject the bottle to a machine 11 comprising stations for filling 41, Fig. 4, and capping 42. Figs. 6 and 8 show alternative arrangements for the evacuator 48, pre-rinser 49 (Fig. 6 only), filler 50, capping station 51, and apparatus 52 to transfer the bottles to a carton 26. The bottles move ten abreast between the filling, closing &c. stations by intermittent motion. The pre-rinsing and filling apparatus 6 and 11 may be enclosed in a sterile atmosphere.
Patent ES-336734-A1 (ES)
Title: Substituted 10-Aminoalkyl-9,10-Dihydroanthracenes
IPC: C07D295/06
Filed: 1967-02-11
Abstract: Novel compounds of formula wherein R is H or C 1-4 alkyl, Y is halogen, C 1-4 alkyl, CF 3 , alkylthio, CN or dimethylsulphamoyl, A is C 2-4 alkylene and Z is amino, mono- C 1-4 -alkylamino, di-C 1-4 -alkylamino, or a monocyclic heterocyclic amino group containing 4- 12 carbon atoms such as morpholino, thiamorpholino, pyrrolidino, piperidino, or piperazino, or piperazino substituted in the 4-position by C 1-4 alkyl, hydroxy-C 1-4 -alkyl, #-acetoxy-C 1-4 - alkyl, or #-hydroxyalkoxy-C 1-4 -alkyl, and acid addition salts thereof, are prepared by reduction of the corresponding anthracenes of formula optionally followed by salt formation and/or modification of any piperazine 4-substituent if present. Pharmaceutical compositions having antidepressant and tranquillizing activity in conventional formulations comprise an above novel compound and a carrier therefor.
Patent ES-336848-A1 (ES)
Title: Process for agglomerating coffee
IPC: A23F5/38
Filed: 1967-02-15
Abstract: In a process for producing coffee agglomerates connected by bonds made of melted coffee solids, soluble coffee particles are moistened to render them sticky and contacted to form agglomerates, sufficient moisture (8-15%) being present in thermoplastic point of the coffee at the points of contact to a level insufficient to dissolve the contact points, and the agglomerates are heated during drying to above the thermoplastic point to fuse the particles. The coffee is initially moistened with between 1% and 5% total moisture, agglomerates are formed and the moist agglomerates are fused during drying in humidified air having a wet bulb temperature of between 110 DEG F. and 150 DEG F., sufficient moisture (8-15%) being present in the surface portions of the coffee particles to accomplish fusion at these temperatures. A working example is directed to the treatment of spray-dried "instant" coffee.
Patent ES-337290-A1 (ES)
Title: Electro-Optical Devices
IPC: G02F1/1524
Filed: 1967-02-25
Abstract: An electro-optical device, Fig. 6, comprises an electrochromic layer 26 positive or negative photoconductive layer 50, e.g. CDS and insulating layer 34 between electrodes 24, 28. For radio-photographic applications layer 50 may be an ionizing radiation conductive material, the radiation through image plate 52 being light, X-rays, electron beams, gamma rays, or beta rays. Persistent electrochromic materials are referred to which remain in the absorptive state on removal of the electric field and may be reverted to the initial state by the application of a reverse polarity field or by short-circuiting. The radiation sensitive layer and electrochromic layer may be flexible or rigid films as in a roll film or plate camera. In Fig. 7 (not shown) a writing electron beam may replace the stylus (241). In these devices the electrochromic material comprises a transition metal compound in which the transition metal can exist in different stable oxidation states within the temperature range- 50 to 125 C., the different oxidization states having different electromagnetic radiation absorption characteristics. The transition metal compound is defined as containing a transition metal taken from groups IB, IIB, IIIA, IIIB, IVA, VA, VIA, VIIA and VIII and an element from groups VI B and VIIB. A wide range of materials is disclosed.
Patent ES-339128-A1 (ES)
Title: Azabicycloalkane derivatives
IPC: C07D209/52
Filed: 1967-04-11
Abstract: Compounds of the general formula and their salts, wherein R is H or 1-4 C-alkyl are prepared either by heating a compound of the formula with a compound B-NH-R where one of A and B is H and the other is an N-cyanocarboxamidine radical in the presence of at least one equivalent of an acid or (when R is H only) reacting compound II (A=H) with a pyrazole derivative of the formula wherein R 1 and R 2 are H, 1-4 C alkyl, aryl or aralkyl radicals, in a suitable solvent and in the presence of at least one equivalent of acid. N1 - leyano - 3 - azabicyclo[3,2,0] - heptane - 3- carboxamidine is prepared from 3-azabicyclo [3,2,0]heptane, HCI and Na dicyanimide and N - guanyl 1 - pyrazole - carboxamidine from 1 - pyrazole-carboxamidine and triethylamine. Pharmaceutical compositions comprise the compounds I and an inert carrier. The compounds which are useful as antidiabetic agents are administered orally in the usual forms.
Patent ES-342646-A1 (ES)
Title: Process for the production of New N-Substituted Amides and Esteramides of Phosphoric and Thiophosphoric Acid
IPC: C07F9/6584
Filed: 1967-07-05
Abstract: Novel compounds of the formula where R 1 is C 1-4 alkyl substituted by one or more halogen atoms, X 1 is oxygen or sulphur, Y is an oxygen atom or a group of the formula -NH- or -NZ 1 -, where Z 1 is a C 1-4 alkyl group optionally substituted by one or more halogen atoms or hydroxy groups, each Z represents hydrogen, halogen, C 1-4 alkyl, hydroxy, or hydroxymethyl, m is 2 or 3, and X 2 is ethyleneimino or a group of formula optionally substituted by one or more halogen atoms or hydroxy groups, and X is halogen or hydroxy, are prepared (a) by reacting where X 3 is halogen with or (b) reacting a compound X 2 H with a compound of formula in the presence of an acid-binding agent or (c) by reacting a compound of the first general formula above (where R 1 is C 1-4 alkyl substituted by one or more hydroxy groups) with a halogenating agent or (d) by heating a compound of formula at an elevated temperature, where R 5 is an alkyl, aryl or aralkyl group or (e) by reacting a compound of formula where Z 2 is H or Z 1 , with a compound of formula HO(CZ 2 )mZ 3 , where Z 3 is halogen, in the presence of an acid-binding agent at elevated temperature. Reactions (a), (b) and (c) are preferably carried out in an inert organic solvent, at room temperature or at elevated temperature. Pharmaceutical compositions comprise a compound of the first general formula above, together with a pharmaceutically acceptable carrier.
Patent ES-343250-A1 (ES)
Title: Improvements relating to new Reactive Heavy Metal-containing Formazane Dyestuffs, and their use
IPC: C09B62/006
Filed: 1967-07-20
Abstract: The invention comprises reactive, heavy metal-containing formazane dyestuffs of Formula I wherein A represents the radical of a diazo component which has a substituent X in the o-position to the azo bond X represents a metal-binding substituent R represents an optionally substituted aliphatic hydrocarbon radical, a cycloaliphatic radical or a carbocyclic-aromatic or heterocyclic-aromatic radical R1 represents hydrogen or a C 1-5 alkyl.group Y represents an acyl radical which forms at least one covalent bond with the substrate under dyeing conditions Z represents a salt-forming, water-solubilizing group which dissociates acid in neutral water. Me represents a heavy metal of the atomic numbers 24 to 30, and m represents a positive whole number of at most 7 by coupling the diazonium compound of an amine X1-A-NH 2 , wherein A has the meaning for Formula I, and X1 represents a metallizable group or a substituent which can be converted thereto during metallization with a coupling component of Formula III wherein Y, R1 and R have the meanings given for Formula I, and Q represents hydrogen or a substituent which can be replaced by azo coupling to form a formazane dyestuff of Formula IV wherein A, R, R1, Y, Z and m have the meanings given for Formula I, and X1 has that given for Formula II, the components being so chosen that the formazane dyestuff of Formula IV contains at most six Z groups, and reacting the formazane dyestuff obtained of Formula IV simultaneously or subsequently with an agent introducing a heavy metal Me to form a formazane dyestuff of Formula I. The dyes may be used to colour wool, silk, synthetic polyamides and polyurethanes and, in particular, cellulose fibres in green and blue shades.