baber/WOPTO huggingface dataset:
Patent EP-2588479-A4 (EP)
Title: 2-pyridyl substituted imidazoles as therapeutic alk5 and/or alk4 inhibitors
Inventor: KIM DAE KEE
IPC: C07D471/04
Filed: 2011-06-24
Abstract: This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-&bgr; (TGF-&bgr;) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.
Patent EP-0078850-A4 (EP)
Title: Heat transfer components for stirling-cycle, reciprocating, thermal machines.
Inventor: MOSCRIP WILLIAM MATTHEW
IPC: F01B3/04
Filed: 1982-05-14
Abstract: Advantageous specific applications of copper matrix composites, manganese-copper alloys, and structural ceramics to the design and construction of improved Stirling-cycle, reciprocating, thermal machines are disclosed which provide both high temperature strength and high or low thermal conductivity in components with matched thermal expansion coefficients. In the preferred embodiment (figure 3) the heater assembly (23) is made from material with a high thermal conductively such as GLIDCOP while the expansion block (28) is made of a material of low thermal conductivity, such as a manganese copper eutectic alloy.
Patent EP-0173696-A4 (EP)
Title: Pleated filter and method and apparatus for fabricating same.
Inventor: BERGER RICHARD M
IPC: B01D27/06
Filed: 1985-01-09
Abstract: A filter for separating constituent components of fluids includes a plural-layer sheet-like member which is multiply pleated to provide layers of the same or different porosity or to provide structural support layers (67, 70) for pleating a soft or membrane-like filter layer (65). The multiple layers may be prejoined or delivered from individual locations to a pneumatic conveyor passage (60) of predetermined cross-section through which the adjacent layers are conveyed by a conveyor gas. The layers are crimped to form pleats by withdrawing the material at a lower linear speed than that at which it supplied to the passage. Pleating is facilitated by venting the conveyor gas at a passage section (35) of enlarged cross-section. The pleating material is subjected to a hot gas, such as steam, and then cooled by a cooling gas to effect bonding of the layers in the pleated state.
Patent EP-0290464-A4 (EP)
Title: Analog-digital converter
IPC: H03M1/44
Filed: 1987-01-23
Abstract: Two A-D converters which provide different embodiments of the general successive rectification algorithm Vout = 2|Vin| - Vref. One stage of a synchronous parallel converter generally comprises a comparator (32), and an op amp (35) with Vin as an input to its inverting input, the noninverting input connected to ground, and the output being Vout, with a first capacitor (C1) bridging the inputs of the op amp, and a second capacitor (C2) of half the capacitance of the first capacitor feeding back from the output of the op amp to its noninverting input. Each stage's Vin is compared to ground to provide a bit of information. One stage of the continuous parallel converter comprises a complementary transistor pair (M1, M2) and three current mirrors (70, 75, 80). The transistor pair, a first current mirror (70) and a second current mirror (75) act as a rectifier. The third current mirror (80) acts to subtract Iref from the rectified amplified Vin, and has Vref as an input and an output connected to Iout. The Iout of one stage acts as the Iin to a second stage, and  the stages are cascaded. The direction of flow of Iin to each stage provides bits of information.
Patent EP-0368933-A4 (EP)
Title: Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes.
Inventor: MINASKANIAN GEVORK
IPC: A61P31/04
Filed: 1988-07-25
Abstract: This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula  <IMAGE>  wherein X may represent sulfur, oxygen or 2 hydrogen radicals; Y may represent -CH2-, -NH- or oxygen; n and m are integers of from 1 to 3; p is an integer of from 3 to 17; q is 2, 4, 6 or 8; wherein p>/=9; and R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl. These compositions are useful in topical or transdermal applications of the physiologically-active agent.
Patent EP-0386107-A4 (EP)
Title: Method and apparatus for processing and transporting sheet materials
IPC: G03D5/06
Filed: 1988-10-25
Abstract: The present invention provides an apparatus and method for processing a sheet material, for e.g. a photosensitive sheet material, with a flowable process substance. The flowable process substance is distributed via a pliable web which has defined on one of its surfaces a plurality of protrusions which define interconnected fluid reservoirs and distribution channels, and which are in surface-to-surface contact with the sheet material over a substantial portion its surface area while the sheet material is transported relative to such web.
Patent EP-0390868-A4 (EP)
Title: Pseudorandom dither for frequency synthetis noise
IPC: G06F3/05
Filed: 1988-12-08
Abstract: A method and apparatus for reducing spurious output noise in digital frequency synthesizers employing sine amplitude converters connected to Digital-to-Analog converters to generate analog waveforms from sine amplitude data. Random or pseudorandom numbers having a value equal to or less than plus or minus one-half of a minimum quantization step or value change for the sine amplitude data are generated and added to the sine amplitude data with the resulting sum being transferred to the Digital-to-Analog converter. In one embodiment, a summation circuit is connected between an output of the sine function converter and an input of the Digital-to-Analog converter and also has a second input connected to a pseudorandom number generator which provides Pseudorandom numbers varying in value over a range of +/-1/2n+1 times a least significant step value, or bit for base 2, of a corresponding Digital-to-Analog input data value where n is greater than or equal to 1.
Patent EP-0489729-A4 (EP)
Title: Process for making highly reactive sub-micron amorphous titanium diboride power and products made therefrom
IPC: C01B35/04
Filed: 1989-08-28
Abstract: A material of manufacture comprising sub-micron particulate amorphous titanium diboride formed by a process which comprises the steps of forming a powdered reaction mixture of titanium oxide, boron oxide and magnesium, exothermically reacting the reaction mixture in an atmosphere including air to yield a reacted mass containing titanium diboride and magnesia, leaching the reacted mass with a leaching solution having a pH in the range of about 0.5 to about 8, and recovering from the leaching solution sub-micron titanium diboride having a surface area of from about 25 to about 49m<2>/gm; and a material of manufacture resulting from the hot pressing of the sub-micron particulate titanium diboride material of this invention which has a hardness of from about 2800 to about 3400 Knoop, an elastic modulus from about 700 to about 813 GPa, a forming temperature of from about 1500  DEG C or less, and a grain morphology aspect ratio of from about 2:1 to about 100:1.
Patent EP-0457829-A4 (EP)
Title: Device for releasably supporting a plurality of objects
IPC: A47J47/16
Filed: 1990-02-06
Abstract: A device (10) including a pair of support elements (16, 18) for releasably supporting a plurality of objects such as cans (12) and which allows the selective removal or replacement of any one of the objects without disturbing the others releasably supported thereby.
Patent EP-0489840-A4 (EP)
Title: Shutterless optically stabilized capnograph
IPC: G01N21/35
Filed: 1990-08-27
Abstract: Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of filtered (60, 61, 62, 16, 18, 26, 28, 36, 38) thermopiles (12, 14, 22, 24, 32, 34) in series and processing the resulting differential signal (242).
Patent EP-0523181-A4 (EP)
IPC: B24C7/00
Filed: 1991-04-04
Abstract: Appareil de sablage à pression industriel classique (8) modifié pour permettre un contrôle de la pression exercée dans le pot de projection qui est supérieure à la pression exercée dans la conduite où la matière de sablage et l'air sont mélangés pour transmettre un mélange à la tuyère, puis à la pièce à traiter. Un dispositif de contrôle de la matière de sablage (18), avec une aire fixe mais pouvant être facilement modifiée, est placé entre le pot de projection (10) et la conduite de mélange matière de sablage/air (20) pour mesurer le débit de la matière de sablage et maintenir le différentiel de pression entre le pot de projection et la conduite. Cela permet de contrôler le débit de la matière de sablage quand des débits lents, inférieurs à environ 10 livres par minute sont nécessaires.
Patent EP-0555233-A4 (EP)
Inventor: JOHNSON ELLEN BUMPUS
IPC: H04M3/50
Filed: 1991-08-27
Abstract: In one embodiment, the personalized greeting card includes an independent, detachable, electronic memory device (22) that stores electronic signals, a retrieval mechanism for retrieving the electronic signals from the memory device (22), a voice synthesizer which obtains these electronic signals and produces audible sounds representative of the personalized message, and a switch (16) that controls the retrieving device and the voice synthesizer (20). Prior to incorporating the memory device (22) in the card, an EPROM translation machine (52) converts the personalized message obtained from the sender of the card into appropriate electronic signals and stores those representative electronic signals in the memory device (22). The memory device (22) is then dettached from the EPROM and mounted in the circuitry disposed in the greeting card (10).
Patent EP-0563214-A4 (EP)
Title: Bifunctional antibodies and method of preparing same
Inventor: CURTIS PETER J
IPC: C07K16/46
Filed: 1991-12-03
Abstract: A recombinant antibody capable of binding to two different antigenic sites, contains Fab fragments from the same or, preferably, different antibodies, which are brought into association by complementary interactive domains which have been inserted into a region of the antibody heavy chain constant region.
Patent EP-0574419-A4 (EP)
Inventor: DUNMIRE CHARLES W
IPC: F16K15/03
Filed: 1992-01-21
Abstract: L'invention se rapporte à un dispositif anti-refoulement qui possède des performances accrues et qui est plus facile à installer. Les soupapes de retenue (12, 14) sont conçues pour qu'il soit plus aisé de rediriger l'écoulement le long de la trajectoire desirée, lorsqu'elles sont en position ouverte. La trajectoire est telle que le nombre de changements de direction de l'écoulement moyen offrant la moindre résistance hydrodynamique est réduit, cette trajectoire étant de préférence conçue à cet effet avec un angle de 180 degrés environ. Les soupapes de retenue (12, 14) sont conçues pour réduire ou éliminer l'écoulement divergeant le long des bords des disques (32, 72) des soupapes. Une soupape de retenue (12, 14) présentant une pression de maintien réduite en position ouverte comporte un dispositif de sollicitation, tel qu'un ressort (52, 74), directement relié à un clapet pivotant (32, 72) à une extrémité (64, 66) et au corps de soupape à l'autre extrémité (66, 64). Aucune liaison pivotante fonctionnelle n'est utilisée entre le ressort (52, 74) et le clapet (32, 72). Le clapet (32, 72) est de préférence relié uniquement par son point de pivot (43, 43') au corps de soupape et par le ressort (52, 74) qui le relient audit corps de soupape.
Patent EP-0580719-A4 (EP)
Title: Methods for treating cotton-containing fabrics with cellulase.
Inventor: CLARKSON KATHLEEN A
IPC: D06M101/02
Filed: 1992-03-30
Abstract: Disclosed are improved methods for treating cotton-containing fabrics as well as the fabrics produced from these methods. In particular, the disclosed methods are directed to contacting cotton-containing fabrics with a cellulase solution containing a fungal cellulase composition which is substantially free of all CBH I type cellulase components. Cotton-containing fabrics so treated possess decreased strength loss as compared to fabrics treated with a cellulase solution containing a complete cellulase composition.
Patent EP-0588917-A4 (EP)
IPC: C07D417/04
Filed: 1992-05-28
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula:   <IMAGE>   wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
Patent EP-0643626-A4 (EP)
Title: Chiral catalysts, catalytic oxidation and disproportionation reactions, and methods of producing epoxychromans and taxol.
Inventor: JACOBSEN ERIC N
IPC: C07D301/14
Filed: 1992-08-26
Abstract: Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general structure (I). In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.
Patent EP-0641352-A4 (EP)
Title: 4-ethoxy 5-fluoro 2'deoxyuridine.
Inventor: SOWERS LAWRENCE C
IPC: C07H19/056
Filed: 1994-02-17
Abstract: 4-Ethoxy 5-fluoro 2'deoxyuridine and its use to synthesize oligonucleotides containing 5-fluoro 2'deoxyuridine are disclosed.
Patent EP-0730765-A4 (EP)
Title: Associative text search and retrieval system
Inventor: HOLT JOHN
IPC: G06F17/30
Filed: 1994-11-22
Abstract: An associative text search and retrieval system uses one or more front end processors to interacting with a network having one or more user terminals connected thereto to allow a user to provide information to the system and receive information from the system. The system also includes storage for a plurality of text documents, and at least one processor, coupled to the front end processors and the document storage. The processor(s) search the text documents according to a search request provided by the user and provide to the front end processor a predetermined number of retrieved documents containing at least one term of the search request. The retrieved documents have higher ranks than documents not provided to the front end processor. The ranks are calculated using a formula that varies according to the square of the frequency in each of the text documents of each of the search terms.
Patent EP-0682844-A4 (EP)
Inventor: SHIPP JOHN I
IPC: H04N13/239
Filed: 1994-11-21
Abstract: Un système d'imagerie vidéo séquentiel utilise un détecteur vidéo (15) présentant une architecture d'interlignes selon laquelle les données d'images sont déplacées depuis des éléments détecteurs vers des éléments de mémorisation d'interlignes adjacents. L'objet visualisé est éclairé de manière séquentielle par des sources de lumière colorée (11-13) pour générer des signaux vidéo de luminance et de chrominance. La collecte des données d'image correspondant à des signaux de couleurs de faible niveau est effectuée dans le détecteur (15). Un processeur (35) de signaux numériques comprend des circuits tampon set des circuits de moyennage qui permettent d'actionner la tête de la caméra et l'unité de base de manière asynchrone.
Patent EP-0770088-A4 (EP)
Title: Novel cytokine designated lerk-5
Inventor: CERRETTI DOUGLAS P
IPC: C07K19/00
Filed: 1995-07-06
Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
Patent EP-0722292-A4 (EP)
Title: Device for inserting a flexible intraocular lens
Inventor: FIGUEROA DENNIS ALEXANDER
IPC: A61F9/007
Filed: 1995-08-07
Abstract: This invention is a device for inserting a flexible intraocular lens (12) into an eye comprising a tubular member (16) and a plunger (18). The tubular member includes a staging area (45), a lumen, and an open distal end (95). The staging area supports the lens in an unstressed state prior to engagement by the plunger. In the unstressed state, the optic (48) of the lens is suspended in a pocket to avoid any substantial contact with interior portions of the tubular member. The plunger includes a slot (132) in its distal tip fo receiving and gripping the lens. With this construction, the lens can be inserted into the eye in one continuous motion. Further, the plunger holds the lens when the lens is moved out of the tubular member.
Patent EP-0881234-A4 (EP)
Inventor: OSHINO YASUHIRO
IPC: C08F8/08
Filed: 1996-02-16
Abstract: Procédé d'élaboration d'un copolymère bloc époxydé conçu pour des agents ou des adjuvants de modification de polymères caoutchouteux ou de polymères résineux, d'adhésifs, de matériaux d'étanchéité, etc. Le procédé consiste à époxyder un copolymère bloc pouvant être en partie hydraté et comprenant un bloc polymère (A) renfermant un composé hydrocarbure aromatique vinylique comme composant principal et un autre bloc polymère (B) renfermant un composé diène conjugué comme composant principal pour établir la synthèse d'un copolymère bloc époxydé (C) puis à récupérer ce polymère dans une suspension épaisse ou une solution de ce polymère dans un solvant organique par distillation à la vapeur en présence d'un tensio-actif. Il est préférable que le tensio-actif soit non ionique et qu'il corresponde, en particulier, à la formule générale: HO(C2H4O)a(C3H6O)b(C2H4)c,OH, dans laquelle a, b et c représentent individuellement un nombre de 1 à 1000, ce tensio-actif ayant un poids moléculaire moyen compris entre 3000 et 20000 et renfermant de 20 à 90 % en poids de polyoxyéthylène. Selon ce procédé, le copolymère bloc époxydé ainsi produit peut être aisément extrait du mélange de réaction sans dégagement de chaleur prolongé, ce qui empêche l'ouverture des liaisons du groupe époxy . Ce procédé permet également d'obtenir un copolymère bloc époxydé ayant un équivalent époxy tel qu'il confère une élasticité élevée et les caractéristiques des composés époxy.
Patent EP-0767898-A4 (EP)
Title: Coin hopper measurement and control system
Inventor: FILIBERTI PETER L
IPC: G07F17/32
Filed: 1996-03-26
Abstract: The present invention provides a weighing apparatus for weighing coins accumulated in a coin hopper using a load cell and automatically taking a periodic readings of the number of coins accumulated in the hopper. By periodically monitoring the hopper and automatically calculating the number of coins in the hopper, theft of coins and other irregularities can be easily and timely detected. The unauthorized removal of coins during an actual or purported maintenance procedure can be detected by automatically determining a count of coins before a hopper access door is opened, automatically counting the number of coins once the door is closed, and using those two counts to determine the change in the number of coins in the hopper at the time of the change. In a preferred embodiment, the identity of the person opening the hopper door and the time in which the hopper door is opened and closed are recorded, along with any detected discrepancy between the change in coin count and an expected change, if any, in coin count.
Patent EP-0852770-A4 (EP)
Inventor: ROSENBERG LOUIS B
IPC: G06F1/26
Filed: 1996-09-25
Abstract: On décrit un procédé ainsi qu'un dispositif permettant d'obtenir des périphériques à rétroaction tactile, sûrs, bon marché, destinés à des applications grand public. Un microprocesseur (26) associé localement à une interface (14) est couplé à l'ordinateur hôte (12) à l'aide d'un premier bus d'interface (24). Le microprocesseur reçoit des commandes de l'ordinateur hôte sur le premier bus de l'interface, telle qu'une interface RS-232, et commande à un actionneur (30) d'appliquer une force sur un objet (22) d'un utilisateur, tel qu'une manette de jeu, en réponse aux commandes de l'ordinateur hôte. Un capteur (28) détecte les positions dudit objet et émet des signaux en direction de l'ordinateur hôte sur un deuxième bus d'interface (25), tel qu'un bus d'accès pour jeux d'ordinateur personnel, séparé du premier bus. Un commutateur de sécurité (41) de la présente invention déconnecte l'actionneur, lorsque l'interface n'est pas utilisée, et connecte celui-ci lorsqu'une certaine force, dépassant une force prédéterminée, est appliquée sur la manette de jeu, par suite de la prise en main de celle-ci par un utilisateur.
Patent EP-0939068-A4 (EP)
IPC: C07B63/00
Filed: 1996-12-17
Abstract: Cette invention concerne un procédé de purification d'une substance particulière contenue dans un mélange, lequel procédé permet d'obtenir à partir dudit mélange une substance d'une grande pureté de manière relativement simple et en grandes quantités, et comprend les étapes (1) et (2a) ou (2b), à savoir: (1) soumettre le mélange de matières brutes se présentant sous forme de liquide ou de bouillie, et dans lequel une partie de la substance particulière s'est cristallisée, à une cristallisation sous haute pression de manière à accroître la quantité de cristaux de ladite substance particulière et à préparer ainsi des cristaux enrichis de cette substance; et (2a) dissoudre les cristaux enrichis de cette substance particulière dans un solvant qui soit capable de bien dissoudre les cristaux, puis soumettre la solution à une cristallisation dans des conditions de refroidissement de manière à recristalliser la substance particulière; ou (2b) laver les cristaux enrichis de cette substance particulière à l'aide d'un solvant capable de dissoudre le cristal.
Patent EP-0904668-A4 (EP)
Inventor: SHKLARSKY DAN
IPC: H04B17/00
Filed: 1997-06-10
Abstract: L'invention concerne un procédé pour améliorer la capacité d'un système radiotéléphonique cellulaire où une cellule appartient à plusieurs groupes de réutilisation (42, 45). On évalue les risques de brouillage dû à chaque abonné appelant (43, 46), et les abonnés sont affectés à des groupes de réutilisation appropriés où ils n'occasionneront pas de brouillage (44, 47, 48, 49, 50). Le procédé permet aussi d'améliorer la qualité du service (44, 48, 50), c'est-à-dire d'offrir une probabilité de brouillage réduite.