baber/WOPTO huggingface dataset:
Patent YU-158691-A (YU)
Title: 2-(4-PIPERIDINIL)-1H-PIRIDO[4,3-b]INDOL-1-ONI IN SORODNE SPOJINE, INTERMEDIATI IN POSTOPEK ZA NJIHOVO PROPRAVO
Inventor: MARTIN L L
IPC: C07D401/12
Filed: 1991-09-26
Abstract: Predložena prijava se nanaša na nove 2-(4-piperidinil)-1H-pirido(4,3-b)indol-1-one in sorodne spojine, intermediate in postopke za njihovo pripravo. Spojine v smislu izuma kažejo antipsihotično aktivnost in jih lahko zato uporabimo kot zdravila.
Patent YU-208290-A (YU)
Title: 4- i 6-karbamati, srodni fizostigminu, postupak i intermedijeri za njihovo dobijanje
Inventor: GLAMKOWSKY Y E
IPC: C07D487/04
Filed: 1990-11-02
Abstract: Pronalazak se odnosi na 4- i 6-karbamate srodne fizostigminu, formule u kojoj je R1 alkil, cikloalkil, bicikloalkil, aril, ili aril-niži alkil; R2 je vodonik ili alkil, ili grupa -NR1NR2 zajedno gradi monociklični ili biciklični prsten sa 5 do 12 atoma ugljenika; m je 0, 1 ili 2; svak od X je nezavisno vodonik, halogen, niži alkil, nitro ili amino; i na njihove farmaceutski prihvatljive kiselinske adicione soli, i u datom slučaju na njihove geometrijske i optičke izomere i racemske smeše. Pronalazak se odnosi i na postupak i intermediate za dobijanje 4- i 6-karbamata. Jedinjenja prema pronalasku su korisna za poboljšanje raznih disfunkcija pamćenja, značajnih po smanjenoj holinergičnoj funkciji kao kod Alzheimerove bolesti.
Patent YU-229487-A (YU)
Title: Process for preparing (+)-biotine
Inventor: MCGARRITY J
IPC: C07D491/048
Filed: 1987-12-16
Abstract: Process for the production of (+) biotin. A compound of the formula: <IMAGE>   wherein R1 is e.g., an (R)-1-phenylalkyl group, and R2 is, e.g., hydrogen. The desired diastereomer of the formula:   <IMAGE> is separated out. If R2 is H, a protective group is introduced by reaction with, e.g., an aliphatic acid chloride. The diastereomer is converted by reaction with a thiocarboxylic acid salt derivative into the corresponding thiolacetone, which is reacted with a Grignard reactant and subsequently water is split off. Alternatively, the corresponding thiolacetone is reacted with a compound of the formula: (C6H5)3P(+)(CH2)4COOR3.X(-) wherein R3 is, e.g., H, and X is a halogen atom, in the presence of a base to provide a compound of the formula:   <IMAGE>  Such compound is catalytically hydrogenated and then converted into (+) biotin by cleavage of the protective groups.
Patent YU-23301-A (YU)
Title: Process for preparing substituted pyridines
Inventor: DOW ROBERT LEE
IPC: C07D213/46
Filed: 2001-03-27
Abstract: Process for obtaing compounds of the formula wherein N, R1, R2, R3 and x are defined above, used as intermediary in the synthesis of agonists of B-adrenergic receptor.
Patent YU-43502-A (YU)
Title: Hydraulic connectors
Inventor: DAVIDSON PAUL
IPC: F16L19/075
Filed: 2000-12-15
Abstract: A connector for forming a connection between the tubular end of a first fluid conveying member and a threaded end of a second fluid conveying member as a threaded portion (19, 117) for engagement with a threaded end (112) of a second fluid conveying member. The connector is provided with means (39, 141) for engaging an external circumferentially extending groove (31, 137) located on the tubular end of said first fluid conveying member. Means (23, 133) are provided for effecting sealing engagement with said threaded end of said second fluid conveying member.
Patent YU-76404-A (YU)
Title: Use of epothilones in the treatment of brain diseases diseases associated with proliferative processes
Inventor: LICHTNER ROSEMARIE
IPC: C07D493/04
Filed: 2003-02-28
Abstract: This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.
Patent YU-86901-A (YU)
Title: Modified chimeric polypeptides with improved pharmacokinetic properties
Inventor: PAPADOPOULOS NICHOLAS J
IPC: A61P35/00
Filed: 2000-05-23
Abstract: Modified chimeric polypeptides with improved pharmacokinetics are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
Patent RS-91304-A (RS)
Title: Compounds useful in preparing campthothecin derivatives
Inventor: HENEGAR KEVIN
IPC: A61P35/00
Filed: 2003-04-16
Abstract: Novel compounds are provided having formula (I) and salts thereof, where R1 is hydrogen, an alkyl, aralkyl, hydroxymethyl, carboxymethyl, acyloxymethyl or trialkylsilyl group, or a group -CH2NR3R4 where N is a linking nitrogen atom and where (a) R3 and R4 are independently selected from hydrogen and alkyl, alkenyl, hydroxyalkyl and alkoxyalkyl groups; (b) R3 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group, and R4 is -COR5 where R5 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group; or (c) R3 and R4 taken together with the linking nitrogen atom form a saturated 3- to 7-member heterocyclic group. These compounds are useful intermediates in a process to prepare camptothecin derivatives including the anti-cancer drug irinotecan.
Patent AU-1223488-A (AU)
Title: Copolymers of ethylene and 1,3-butadiene
Inventor: WELBORN HOWARD CURTIS JR
IPC: C08F4/6392
Filed: 1987-12-16
Abstract: Ethylene copolymers having in their structure cyclopentane rings connected in the 1 and 2 positions. The ethylene copolymers of the invention may be formed from polymerization of ethylene and butadiene and preferably have a predominance of the copolymer units formed as 1,2-cyclopentane units, preferably trans 1,2-cyclopentane. Other butadiene units incorporate 1,2 and cis and trans 1,4 noncyclic.
Patent AU-1303683-A (AU)
Title: Low hardness rubber composition with lowered dynamic- deformation heating
Inventor: WEIL JOACHIM
IPC: C08L21/00
Filed: 1983-03-30
Abstract: Rubber vulcanisates based on mixtures which contain at least 55% of active fillers and at least 10% of plasticizing oils, having Shore A hardnesses of below 65 DEG  in which the active filler contains inorganic active fillers and 10 to 60% of phenolic resin systems consisting of novolaks and hardeners therefor, all these percentages being based on the weight of the rubber, the weight ratio of active inorganic fillers to the phenolic resin systems being from (9:1) to (1:9); the invention further relates to a process for producing such vulcanisates and rubber articles and tires produced from said vulcanisates.
Patent AU-1344399-A (AU)
Title: Carbon coatings, method and apparatus for applying them, and articles bearing such coatings
Inventor: TEER DENNIS GERALD
IPC: C23C14/32
Filed: 1998-12-02
Abstract: Articles are disclosed which bear a carbon coating layer, wherein carbon-carbon bonding within the coating layer is mostly of the sp2 form: wherein the coating has a specific wear rate under wet conditions of less than 10-6 m3/Nm: wherein the coating has an adhesion critical load of at least 70N: wherein the coating has a hardness of at least 1000 VHN: wherein the coating has a coefficient of friction (dry) of not more than 01. The coating may be a multi-layer coating containing successive metal-containing and carbon layers. The article may be constituted as a medical prosthesis. Methods are disclosed of forming hard wear resistant carbon coatings by sputter ion plating with at least one carbon target in which an ion current density of for example above 0.5 mA/cm2 is applied at the substrate to be coated in order to deposit a carbon-containing coating layer and/or which comprise sputter ion plating with at least one carbon target and at least one metal target in order to deposit a carbon coating layer and a metal-containing coating layer. Coating apparatus suitably comprises magnetron sputter ion plating apparatus having at least one metal-donating target and at least one carbon-donating target. Such apparatus may include at least two magnetrons arranged to generate a magnetic field between them with field lines extending from one magnetron to the or an other, and the magnetrons, and field lines extending directly from one magnetron to the or an other, form a barrier which tends to prevent the escape of electrons from within a plasma-containing working space within which the substrate is coated.
Patent AU-1453100-A (AU)
Title: Cosmetic dispenser
Inventor: LOSIER DONALD P
IPC: B65D47/42
Filed: 1999-10-28
Abstract: The dispenser is of an ergonomic shape, provides for single hand use in the actuation of the dispenser and the application of substances to the skin, and can accommodate different application surfaces. The dispenser has a barrel closed at one end and an angled barrel extension at another end. The push button actuator to dispense the product is located in the barrel extension. On the upper end of the barrel extension is an applicator surface. This applicator surface can be microporous, porous or have separate distinct apertures. A gel, lotion or other semisolid liquid is stored in the barrel. Upon pressing the actuator the elevator rises upwardly with the gel, lotion or other semisolid liquid passing through conduits to the applicator surface. It then is applied to the skin. The pressing of the actuator causes a threaded rod to rotate which raises the elevational. By placing the actuator at a mid to upper part of the dispenser, the dispenser can be gripped with the thumb on the actuator and the other fingers passing behind the barrel of gripping. The actuator can be operated without changing the position of the dispenser in the hand
Patent AU-1627997-A (AU)
Title: Atovaquone pharmaceutical compositions
Inventor: DEARN ALAN ROY
IPC: A61K31/12
Filed: 1997-03-14
Abstract: The invention relates to a process for the production of microfluidized particles of atovaquone having improved bioavailability.
Patent AU-1714699-A (AU)
Title: Recombinant nodavirus compositions and methods
Inventor: HALL STEPHEN G
IPC: C07K14/08
Filed: 1998-12-07
Abstract: Recombinant nodavirus related compositions are disclosed. These compositions include chimeric proteins in which a nodavirus capsid protein is present together with a heterologous peptide segment. The heterologous peptide includes at least one cell-specific targeting sequence, such as a B cell epitope, a T cell epitope, or a sequence specific for another cell type, such as a hepatocyte. The chimeric proteins can be assembled to form chimeric virus-like particles. The chimeric virus-like particles are useful in therapeutic applications, such as vaccines and gene-delivery vectors, and in diagnostic applications, such as kits for the testing of body tissue or fluid samples. Methods for the use of recombinant nodavirus related compositions in therapeutic and diagnostic applications are also described.
Patent AU-1737292-A (AU)
Title: Process for removing acetone from a mixture comprising acetone, methyl acetate and methyl iodide
IPC: C07C51/573
Filed: 1992-06-02
Abstract: A process for removing acetone from an acetone/methyl acetate/methyl iodide mixture comprises extractive distillation with water being introduced to the distillation zone above the point of introduction of the mixture and acetic acid being introduced at or above the point of introduction of the mixture. In a preferred embodiment the mixture is subjected to an initial extraction with an aqueous extractant to remove most of the methyl iodide. The process is particularly applicable to removing acetone by-product in carbonylation processes for the production of acetic anhydride. <IMAGE>
Patent AU-1876997-A (AU)
Title: Printing unit using various ink types
Inventor: MURRAY ROBERT RICHARD
IPC: B41F31/00
Filed: 1997-02-26
Abstract: A printing unit (1) of a rotary printing press for using various ink types is provided. The printing unit includes an inking mechanism (45), a print cylinder (3), and a blanket cylinder (2). The inking mechanism (45) and the cylinders (2, 3) are mounted in side walls of the printing unit (1). A housing (14) at least partially surrounds the inking mechanism (45) and the cylinders (2, 3) to maintain a surrounding atmosphere within an at least semi-enclosed area (100) of the printing unit (1). A chemical agent is selectively added to the atmosphere in the semi-enclosed area (100) to reduce the rate of evaporation of a substance in the ink.
Patent AU-2193392-A (AU)
Title: Long-term delivery device including hydrophobic loading dose
IPC: A61K9/00
Filed: 1992-06-11
Abstract: The invention provides a dispensing device comprising a loading dose (first agent delivery means) for short-term and continuous delivery of an agent having a high potency, retained together with a long-term dispensing device (second agent delivery means) capable of a long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent may be delivered to the environment of use over time. A rapid initial delivery of beneficial agent is followed by continuous and prolonged delivery of agent.
Patent AU-2357888-A (AU)
Title: Process and device for treating a photographic recording material
IPC: G03F7/30
Filed: 1988-10-07
Abstract: Process and device for treating photosensitive recording material comprising a carrier layer and at least one photosensitive recording layer having a hardened image, e.g., halftone images, whereby undesirable streaks are eliminated particularly in halftone areas, the recording material while being transported flat is successively treated with washing agent in at least two separated wash sections by jets shaped and arranged so that each surface unit area of the recording layer is sequentially struck by at least two wash spray cones which do not contact each other prior to impacting the recording layer. The amount of washing agent impacting a unit area of the surface of the recording material per unit time and its impact velocity are selected so that only image free areas of the recording layer are removed. Halftone copies reproduction printing forms, etc., are produced.
Patent AU-2360000-A (AU)
Title: Synthetic virus-like particles with heterologous epitopes
Inventor: JANSEN KATHRIN U
IPC: C07K14/025
Filed: 1999-12-14
Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.
Patent AU-2378600-A (AU)
Title: Inhibitors of the bitter taste response
Inventor: MARGOLSKEE ROBERT F
IPC: A23L27/23
Filed: 1999-12-22
Abstract: The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in foods and pharmaceuticals. The methods of the invention may further be used to characterize the gustatory perception of novel tastants.
Patent AU-2390588-A (AU)
Title: Method and apparatus for fire control
Inventor: PAPAVERGOS PANAYIOTIS GEORGE
IPC: B05B7/04
Filed: 1988-10-14
Abstract: Method and apparatus for fire control comprising the use of a gas-liquid twin fluid spray nozzle. In one embodiment the spray nozzle comprises a mixing chamber (1) having a gas inlet (4) and one or more outlets (6) at opposite ends, two or more liquid inlets (7) between the gas inlet (4) and the outlets (6) and a mixing zone (11) between the liquid inlets (7) and the outlets (6). In another embodiment the spray nozzle comprises a mixing chamber having a plurality of gas inlets, liquid inlets and outlets, the inner surface of the mixing chamber being capable of aiding mixing of gas and liquid introduced through the inlets. The nozzles may be used in fixed, portable or semi-portable fire control systems.
Patent AU-2553784-A (AU)
Title: 1-(2-carbethoxy 4-benzalkylamido phenoxy) 3-amino 2- propanols
Inventor: BOULEY ETIENNE
IPC: A61K31/00
Filed: 1984-03-13
Abstract: 1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE Compounds characterized in that they respond to formula :  see diagramm : EP0122827,P20,F2  in which : - R and R' may each designate an atom of hydrogen, an atom of halogen, a nitro group or alkyl or alkoxy radicals with C1-C5, branched or not, or a SCH3 or CF3 group ; - R1 represents a lower alkyl radical with 1 to 5 carbon atoms, branched or not ; - R2 represents a lower alkyl radical with 1 to 5 carbon atoms, branched or not ; and - n designates an integer less than 5. 1. Claims for the Contracting State : AT A process for preparing novel compounds responding to formula  see diagramm : EP0122827,P21,F2  in which : - R and R' may each designate an atom of hydrogen, an atom of halogen, a nitro group or alkyl or alkoxy radicals with C1-C5, branched or not, or a SCH3 or CF3 group ; - R1 represents a lower alkyl radical with C1 -C5 , branched or not ; - R2 represents a lower alkyl radical with C1 -C5 , branched or not ; and - n designates an integer less than 5, characterized in that said process comprises the step of reacting a base of formula NH2 -R2 where R2 is as defined hereinabove, on a compound of formula (II) without solvent or in a conventional organic solvent such as alcohols, at a temperature of between 20 degrees C and 150 degrees C, see diagramm : EP0122827,P21,F3  R, R', R1 and n being as defined hereinabove.
Patent AU-2639099-A (AU)
Title: Rim lock of glasses frame and glasses frame
Inventor: KAMIYA KAORU
IPC: G02C1/08
Filed: 1999-02-19
Abstract: To provide a closing block of the frame wherein the lens can be tightly fixed to the rim without rattling and the installing/removing of the lens can be easily operated even if the process precision of the outer shape of the lens is worse. The locking part 10 provided to the lower end portion 3c of the rim 3 is loosely inserted to the loose insert groove 9f of the locking part 9 that is fixed to the upper end portion 3b of the rim 3, and the locking part 10 is urged toward the upper end portion 3b of the rim 3 by the elastic part 11 that is provided between the bottom wall plate 9d of the locking part 9 and the locking part 10. By the urging force the lens 2 to be inserted to the rim 3 is certainly fixed to the rim 3. Moreover, because the inner shape of the rim 3 is expanded by pulling out the cut 3a of the rim 3 and is shrunk via the elastic part 11 by releasing the cut 3a, the lens 2 can be exchanged without using an exclusive screwdriver. Therefore, the closing block of the frame wherein the lens can be certainly fixed to the rim and the installing/removing of the lens can be easy is obtained. <IMAGE>
Patent AU-2644997-A (AU)
Title: Substrates and inhibitors of proteolytic enzymes
Inventor: QUIBELL MARTIN
IPC: C07K5/06
Filed: 1997-04-24
Abstract: The present invention relates to the field of compounds which are substrates or inhibitors of proteolytic enzymes and to apparatus and methods for identifying substrates or inhibitors for proteolytic enzymes. We have devised a combinatorial method for the rapid indentification of binding motifs which will greatly expedite the synthesis of inhibitors of a variety of proteolytic enzymes such as aspartyl proteases, serine proteases, metallo proteases and cysteinyl proteases.
Patent AU-2706197-A (AU)
Title: Improvements in or relating to long-acting antimicrobials
Inventor: PATTERSON ALAN
IPC: A61P29/00
Filed: 1997-05-06
Abstract: Preparation of a veterinary product (I) involves formulating an intimate admixture of a long-acting antimicrobial (II) and an antiinflammatory agent (III) for parenteral administration. Also claimed are (I) obtained by the process.
Patent AU-2812495-A (AU)
Title: Engine assembly comprising an internal combustion engine and a steam engine
Inventor: PLATELL OVE
IPC: F01K3/10
Filed: 1995-06-19
Abstract: PCT No. PCT/SE95/00754 Sec. 371 Date Dec. 19, 1996 Sec. 102(e) Date Dec. 19, 1996 PCT Filed Jun. 19, 1995 PCT Pub. No. WO95/35433 PCT Pub. Date Dec. 28, 1995An engine assembly that includes an internal combustion engine and a steam engine both designed to operate at speeds of optimal efficiency at normal engine driving conditions. A heat exchanger recovers heat losses from the internal combustion engine's exhaust gases and coolant to produce steam to operate the steam engine. Excess steam produced by the heat exchanger but not directly used by the steam engine is supplied to a steam buffer which stores the excess steam and energy and delivers steam to drive the steam engine during short periods of high load as required. The engine assembly is particularly advantageous in applications for propulsion of heavy vehicles such as trucks, freight trains or ships.
Patent AU-2812695-A (AU)
Title: Turning device for conveyor belt
Inventor: JOHANSSON ROBERT
IPC: B65G15/08
Filed: 1995-06-21
Abstract: An endless conveyor belt (1) consists of a flexible material (2) and comprises two tensile-force-absorbing members (3, 4) which extend over the entire length of said conveyor belt and are each fixedly connected to a respective edge portion of the belt. A turning device for this conveyor belt comprises two deflection pulleys (5, 6) which are each positioned in one of two planes intersecting one another along an intersecting line (11). Means (12, 13; 18, 19) are arranged for guiding the tensile-force-absorbing members (3, 4) in first paths (14, 15) substantially from the intersecting line (11) and tangentially inwards to and in, respectively, second paths (20, 21) substantially towards the intersecting line and tangentially outwards from the circumference of the respective deflection pulley (5, 6). Means (18, 19; 22) are arranged for guiding the flexible material of the conveyor belt to a bag shape facing the first paths along the second paths from the deflection pulleys towards the intersecting line and, finally, moving together tensile-force-absorbing members essentially into contact with each other. Means (18, 19; 23) are arranged for turning the conveyor belt through at least 90 DEG  around the longitudinal direction thereof directly after moving together the tensile-force-absorbing members.
Patent AU-2900295-A (AU)
Title: Peptide, a method of obtaining it and a pharmaceutical compound based on it
Inventor: DEIGIN VLADISLAV ISAKOVICH
IPC: A61K38/08
Filed: 1995-06-27
Abstract: The invention is a peptide of general formula (I) X-Tyr-Y-Phe-Z-A, wherein: X represents H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, Har, D-Har, Cyt, D-Cyt; Y represents D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Har, D-Arg, D-His, D-Asp, D-Glu, D- beta -Ala, D-Orn; Z represents Ala, D-Ala, Val, D-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gly, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu,  beta -Ala, D- beta -Ala, Orn, D-Orn; and A represents OH or a substituted amide (C1-C3). According to the invention, the proposed peptide of general formula (I) is obtained by the gradual construction of a peptide chain, starting from C-terminated amino acide Z, in the form of a substituted amide or carboxyl-protected group, by addition using the method of activated ethers or mixed anhydrides of a successive N-protected amino acid; the N-protective group is split off and the successive N-protected amino acid is re-added to produce a tetra- or pentapeptide which is unblocked in the presence of a palladium catalyst, and the target product is separated out. The proposed peptide and a compound based on it can be used as an agent with pronounced opiate-like properties and also has anabolic properties which increase body weight as well as promoting activity in the growing zones and development of the epidermal layer including the hair. The bio-stimulating properties of the claimed peptide are also evident in the healing of wounds and repair processes.