baber/WOPTO huggingface dataset:
Patent NZ-333987-A (NZ)
Title: Inhibitors of cysteine and serine proteases particularly cathepsin K that are useful in the treatment of diseases that cause bone loss
Inventor: MARQUIS ROBERT W
IPC: C07D207/12
Filed: 1997-08-07
Abstract: The specification describes compounds of formula (I) which have the property of inhibiting cysteine proteases of papain and cathepsin K wherein: A is C(O) or CH(OH); R is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R5C(O)-, R5C(S)-, R5SO2-, R50C(O)-, R5R'NC(O)-, R5R'NC(S)-, adamantyl-C(O)-, or R" is H, C1-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R"' is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; each R3 independently is H, C2 6alkenyl, C2-6alkynyl, Het, Ar or C1-6alkyl optionally substituted by OR', SR. NR'2, R'NC(O)OR5, C02R', C02NR'2, N(C=NH)NH2, Het or Ar; R4 is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R5C(O)-, R5C(S)-, R5SO2-, R50C(O)-, R5R'NC(O)-, R5R'NC(S)-, R'HNCH(R')C(O)-, or R5OC(O)NR'CH(R')C(O)-; each R5 independently is C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, Ar-C0-6alkoxy, Het-Co 6alkoxy, or C1-6alkyl optionally substituted by OR', SR', NR'2, R'NC(O)OR5, C02R', C02NR'2, N(C=NH)NH2, Het or Ar; R6 is H, C1-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl and R7 is H, C1-6alkyl, C36cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, R5C(O)-, R5C(S)-, R5SO2-, R5OC(O)-, R5R'NC(O)-, R5R'NC(S)-, R'HNCH(R')C(O)-, or R5OC(O)NR'CH(R')C(O)-; or R6 and R7 are connected to form a pyrrolidine, a piperidine, or a morpholine ring; each R' independently is H, C1-6alkyl, Ar-C0-6alkyl, or Het-Co 6alkyl; R* is H, C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; Y is a single bond or O; each Z independently is CO or CH2; and n isO, 1, or2; or a pharmaceutically acceptable salt thereof. Specific representative compounds are named in Examples 1 - 198.
Patent NZ-334043-A (NZ)
Title: Use of 0.5-9.9% dry weight of 1,4,2-oxathiazines to increase the self-polishing properties of antifouling paints
Inventor: STIENSTRA PIETER SIJBREN
IPC: C09D7/00
Filed: 1997-08-07
Abstract: Substituted 1,4,2-oxathiazines and their mono- and di-oxides, are used as an additive to increase the self-polishing properties of antifouling paints. The additive is used in an amount of 0.5 to 9.9 wt.%, based on the total weight of the dry mass of the composition, preferably 1 to 8 wt.%, most preferably 2 to 4 wt.%. The preferred additive is 3-(3,4-dichlorophenyl)-5,6-dihydro-1,4,2-oxathiazine dioxide.  The substituent in position 3 represents A)  phenyl; phenyl substituted with 1 to 3 substituents selected from hydroxyl, halo, C1-C12 alkyl, C5-C6 cycloalkyl, trihalomethyl, phenyl, C1-5 alkoxy, C1-5 alkylthio, tetrahydropyranyloxy, phenoxy, C1-4 alkylcarbonyl, phenylcarbonyl, C1-4alkylsulfinyl, carboxy or its alkali metal salt, C1-4 alkoxycarbonyl, C1-4 alkylaminocarbonyl, phenylaminocarbonyl, tolylaminocarbonyl, morpholinocarbonyl, amino, nitro, cyano, dioxolanyl or C1-4 alkyloxyiminomethyl; naphthyl, pyridinyl; thienyl; furanyl; or thienyl or furanyl substituted with one to three substituents independently selected from C1-4 alkyl, C1-4 alkoxy, C1-4 alkyloxy, C1-4 alkylthio, halo, cyano, formyl, acetyl, benzoyl, nitro, C1-4 alkyloxycarbonyl, phenyl, phenylaminocarbonyl and C1-4 alkyloxyiminomethyl, or B) a substituent of the above formula wherein X is oxygen or sulphur, Y is nitrogen, CH or C(C1-4alkoxy) and the C6 ring may have one C1-4 alkyl substituent, a second substituent selected from C1-4 alkyl or benzyl being optionally present in position 5 or 6.
Patent NZ-503073-A (NZ)
Title: Inosine, guanosine and 6-thioguanine as stimulators or inhibitors of CNS axonal outgrowth
Inventor: BENOWITZ LARRY I
IPC: A61K31/52
Filed: 1998-02-20
Abstract: A method for stimulating axonal outgrowth of central nervous system neurons wherein said neurons are contacted with inosine.
Patent NZ-503606-A (NZ)
Title: Integrated solid oxide fuel cell and reformer
Inventor: SAMMES NIGEL MARK
IPC: H01M8/02
Filed: 1998-10-01
Abstract: Described is an apparatus for generating electrical power.  The apparatus has a plurality of tubular solid oxide fuel cells (2) contained in a reaction chamber (40). Fuel cells (2) are secured at one end thereof in a manifold block (51), the other ends thereof passing freely through apertures (63) in a baffle plate (47) to reside in a combustion chamber (41). Reaction gases are supplied to the insides of the tubular fuel cells (2) from a plenum chamber (42) below the manifold block (51) and to the reaction chamber (41) surrounding the outsides of the fuel cells through an annular inlet path, which may include a reformation catalyst. The gases inlet path to the plenum chamber (42), and the annular inlet path surrounding the reaction chamber, are both in heat conductive relation with the reaction chamber and the combustion chamber, and raise the gases to formation and reaction temperatures as appropriate.
Patent NZ-504211-A (NZ)
Title: Office utility drawer suitable for use in a computer console for storage of compact discs (CD)
Inventor: STAFFORD LANCE
IPC: A47B88/49
Filed: 2000-10-27
Abstract: A utility drawer (1), including a shroud (2), and a drawer carriage (3) characterized in that the shroud (2) fits into an empty computer drive bay within the computer casing, and the shroud (2) contains the drawer carriage (3), wherein the carriage (3) can be moved between an open and closed position from within the shroud (2). The utility drawer (1) can be used for storing items such as computer tuning tools, CDs, floppy disks or other items that are of frequent use to a person working on a computer
Patent NZ-505139-A (NZ)
Title: Pressure sealer, typically for mailer, with smooth roll and roll with serrations forming nip
Inventor: SPRANGER LEE T
IPC: F16C13/00
Filed: 1999-09-08
Abstract: Business forms having longitudinal and transverse patterns of pressure activated cohesive requiring a sealing force of at least about 50 lbs. per lineal inch are sealed preferably by a single pass through a nip formed by first and second rollers. The first roller is a larger diameter substantially smooth surfaced roll, while the second roller is a small diameter serrated or ribbed roll, e.g. having serrations or ribs having a dimension substantially parallel to the axis of rotation of about 0.04-0.1 (e.g. about +E,fra 1/16+EE ) inches, with spaces therebetween of between about 0.2-0.1 inches (e.g. between about +E,fra 1/32+EE -+E,fra 1/16+EE ) inches. Preferably the serrations or ribs are oppositely directed angled serrations or ribs on different halves of the second roll, each making an angle of at least about 10 DEG with respect to a plane substantially transverse to the axis of rotation. The rolls are typically 4-12 inches in length, and when 6 inches in length or more, a reinforcing roll preferably engages the second roll to prevent bowing of the second roll.
Patent NZ-506665-A (NZ)
Title: Mutant recombinant allergens
Inventor: SPANGFORT MICHAEL DHO
IPC: C07K14/435
Filed: 1999-03-16
Abstract: A recombinant allergen is characterized in that is at is a non-naturally occurring mutant derived form a naturally occurring allergens. At least one surface -exposed conserved amino acid residue of at least one patch of conserved amino acid residues being coherently connected over at least 400 A 2 of the surface of the three-dimensional structure of the allergen molecule as defined as having a solvent accessibility of at least 20%. The patch comprises at least one B cell epitope and is substituted by another residue, which does not occur in the same position in the amino acid sequence of any known homologous protein within the taxonomic order from which the naturally occurring allergen originates. The mutant allergen having essentially the same alpha-carbon backbone tertiary structure as the naturally occurring allergen and the specific IgE binding to the mutated allergen being reduced as compared to the binding to the naturally occurring allergen. Preferably the pollen is derived from a pollen allergen originating from Fagales, Oleales or Pinales. Also described is method of produce the allergen and a pharmaceutical composition comprising the allergen.  The composition can be used to generate an immune response in an individual and as a vaccine against allergic reactions.
Patent NZ-506904-A (NZ)
Title: Vehicle occupant restraint harness with left and right pulleys attached to left and right lap belts
Inventor: BRADLEY GARY FURMAN
IPC: A47C31/00
Filed: 1999-03-16
Abstract: A restraint harness routed in a pulley configuration, which operates between fixed points. The fixed points include: a left and right lap belt (22), each attached to the left and right side (21) of the seat respectively and connected together at the centre of the occupant's body by a multiple point release attachment (31), a left and right shoulder strap adjuster (27) attached to the multiple release attachment (31), and a left and right shoulder guide (28) attached by a neck strap (40) to the top of the seat (42). The shoulder strap adjuster (27) and shoulder guides (28) provide openings through which straps (26, 40) can be routed and bars over which the straps can freely travel.
Patent NZ-512015-A (NZ)
Title: Printing inks comprising a branched vinyl resin
Inventor: GELARDEN DENNIS R
IPC: C09D11/10
Filed: 1999-11-29
Abstract: Described is a printing ink composition comprising a solution of a branched vinyl polymer having a polydispersity of at least 15 and up to 10 000.  Also described is a method of making a printing ink, comprising the steps of: (a) preparing a solution or apparent solution of a branched vinyl polymer by polymerising a monomer mixture that includes at least one monomer having at least two ethylenically unsaturated polymerisable bonds per molecule in the presence of a free radical initiator at a temperature at which the free radical initiator has a half-life of less than two minutes, wherein the polymerisation results in less than 0.5% residual monomer based on the total weight of the monomers being polymerised. (b) combining the branched vinyl polymer with at least one other material to form a printing ink.
Patent NZ-512367-A (NZ)
Title: Non-invasive transudate extraction
Inventor: COOK CHRISTIAN JOHN
IPC: A61B5/157
Filed: 2001-06-14
Abstract: Disclosed is a transudate extraction device for non-invasive extraction of transudate through a target area of a skin barrier of an animal subjected to sufficient ultrasonic energy to induce transudation therethrough, the device including at least: a contacting means for contacting said target area to receive transudate therefrom; a transudate collection chamber in open communication with said contacting means to receive transudate therefrom; circulating means for circulating transudate within said collection chamber to thereby create and maintain a concentration gradient through the skin of a said test subject; said collection chamber having a discharge opening through which exudate collected therein can be discharged.
Patent NZ-513086-A (NZ)
Title: Texture description method and texture-based image retrieval method using gabor filter in frequency domain
Inventor: KIM MUN-CHURL
IPC: G06T7/40
Filed: 2000-11-30
Abstract: A texture description method using a Gabor filter in a frequency domain for describing texture information of an image, comprises: a first step of converting an image, in which an image of a time domain is transformed into an image of a frequency domain; a second step of filtering the transformed image of the frequency domain using a Gabor filter having N*M filtering regions, where N and M are predetermined positive integers; a third step of extracting feature values of the Gabor-filter image in respective channels of a frequency domain division layout corresponding to the N*M filter regions of the Gabor filter; and a fourth step of describing the image texture descriptor using the texture feature values of the image.
Patent NZ-513600-A (NZ)
Title: Digital information system
Inventor: HYLIN MATS
IPC: H04N21/431
Filed: 2000-02-16
Abstract: A method and an arrangement of assigning an information-category and a priority of exposure for spots or blocks of information in a digital information system (10) comprising interfaces for data and telecommunication (26) for round-the-clock transmission of information at places accessible to and frequented by a general public including places where television sets are placed, wherein a control centre (12) has communication interfaces (14) for coordinating and controlling projectors (22), wherein the control centre (12) is able to create and update an exposure list in real time. In said exposure list, it being determined how many times an information is to be exposed during a specific time period. Single spots or blocks of information are assigned a specific information-category and a priority for exposure, which priority is decremented a specific unit of priority for each exposure. The information is displayed according to assigned priority, thus exposure interruption due to visual inaccessibility for information viewers is evened out during said specific time period for single spot or block information.
Patent NZ-515336-A (NZ)
Title: Apparatus and method for producing cheese where cheese molds are filled with curd, closed with a lid, pressed and then the cheese molds are heated prior to removing the cheese from the mold
Inventor: MENNINGA HUGO
IPC: A01J25/12
Filed: 2001-11-07
Abstract: A method for producing cheese, wherein cheese molds are filled with curd, are subsequently closed with a lid and are pressed, whereafter the obtained cheeses are removed from the cheese molds, characterized in that prior to removing the cheeses from the cheese molds, the cheese molds still filled with cheese are heated. An apparatus for producing cheese, comprising at least one filling station for filling the cheese molds with curd and arranging a lid on the curd in the cheese molds; at least one pressing device for pressing the cheese in the cheese molds and at least one unpacking station for removing the cheese from the cheese molds, as well as conveying means for conveying the cheese molds through the apparatus, characterized by a heating device for heating the filled cheese molds after they have left the pressing device and before they reach the unpacking station.
Patent NZ-521355-A (NZ)
Title: Rotavirus pseudoviral particles and use thereof for vectorizing proteins or nucleic acids
Inventor: COHEN JEAN
IPC: C12N15/86
Filed: 2001-03-07
Abstract: A fusion protein comprising an A region consisting of the VP2 protein of a rotavirus, or of a fragment of said protein comprising at least one sequence homologous to that of fragment 121-880 of the VP2 protein of the rotavirus RF bovine strain, bound to a B region consisting of a heterologous polypeptide comprising a polypeptide of interest I.
Patent NZ-523344-A (NZ)
Title: Method and apparatus for permitting a mobile station to operate in a visited network
Inventor: KOWARSCH BENJAMIN
IPC: H04W4/24
Filed: 2001-06-06
Abstract: There is disclosed a method of permitting a mobile station from a home network (1) to operate in a visited network (3). The method includes monitoring an attempt by the mobile station (11) to sign on to said visited network (1) to determine whether a predetermined condition is met, and automatically initiating the creation of an account for the mobile station (11) in said visited network (3) if the predetermined condition is met.
Patent NZ-525522-A (NZ)
Title: A universal flush preservation solution that is supplemented with a number of different constituents
Inventor: POTTS DAVID
IPC: A01N1/02
Filed: 2001-11-20
Abstract: Flush preservation solution for the preservation of cells in the absence of a blood supply. The solution comprising water for injection; at least one saccharide such as a monosaccharide, disaccharide, trisaccharide, or polysaccharide; at least one component with pH buffer properties; at least one component with calcium transport blocking properties or an anti-calcium action activity; a method for the preparation thereof; use thereof in transplantation including organs from heart beating or non-heart beating donors, in surgery including any situation of warm or cold ischaemia, cardioplegia or open heart surgery, whole limb or whole body preservation in experimentation on living tissues or in culturing and preserving engineered cells, tissues and organs, limbs or the whole body; a method for flushing, preserving or flush preservation of cells; and a kit of parts comprising the solution components.
Patent NZ-527641-A (NZ)
Title: Use of supersecretable peptides in processes for their production and for parallel improvement of the exported forms of one or more polypeptides of interest
Inventor: HABERMANN PAUL
IPC: C07K19/00
Filed: 2002-02-08
Abstract: Described is an expression cassette of the form Px-Sx-Bn-(ZR)-transport peptide-(Z1Z2)-protein(Y)-(Z1Z2)-protein (Ym)-T; wherein the expression cassette codes for a transport peptide linked via a sequence Z1Z2 to a second protein which in turn is linked via Z1Z2 to a protein Y1 (m=1) which either corresponds to Y or can be different from Y and the transport peptide improves the rate of secretion and Y and/or Ym where Px is any promoter DNA sequence selected in such a way that optimal yields of the protein of interest become obtainable; Sx is any DNA which, accordingly, encodes any signal or leader sequence which allows optimal yields; Bn is 1-15 genetically encodable amino acids or a chemical bond; Z is the codon of an amino acid selected from the group comprising Lys and Arg; Z1 is the codon of an amino acid selected from the group comprising Lys and Arg; Z2 is the codon of an amino acid selected from the group comprising Lys and Arg; protein Ym is a DNA sequence encoding any protein which can be produced and secreted by yeast (m=1- 5) or is a chemical bon (m=0); R is an Arg codon; transport peptide is a DNA sequence encoding a peptide which can be transported efficiently and which can pass membranes; protein Y is a DNA sequence encoding any protein which can be produced and secreted by yeast and whose biological activity, when Ym is not a chemical bond, is not impaired by a basic dipeptide extension or allows degradation of the extension by carboxypeptidases; T is an untranslated DNA sequence advantageous to the expression, and to processes for the production and use thereof.
Patent NZ-530582-A (NZ)
Title: Therapeutic agents comprising pro-apoptotic proteins, including granzyme, bax and TNF
Inventor: ROSENBLUM MICHAEL G
IPC: C12N5/06
Filed: 2002-07-17
Abstract: Disclosed is a chimeric polypeptide comprising a cell-specific targeting moiety and an apoptosis inducing factor, wherein said apoptosis-inducing factor is a granzyme. Also disclosed is the use of chimeric polypeptides where the apoptosis inducing factor is granzyme, Bax or TNF, in expression cassettes, host cells, and in methods of inducing apoptosis.
Patent NZ-531341-A (NZ)
Title: A wind turbine and single rotor able to be tilted to enable power and torque supply and demand matching
Inventor: CURRIE WILLIAM
Filed: 2002-08-23
Abstract: A wind turbine (1) including: a generator (6); a rotor (8) coupled to the generator; and a plurality of weights (9) distributed about the axis of rotation of the rotor to balance centripetal forces generated by the rotor in use. The weights (9) are provided opposite the rotor and disposed about 120 degrees apart from each other and the rotor in the plane of rotation of the rotor. The rotor (8) is able to be tilted with respect to a drive coupling to the generator (6). Control means (3) controls the load applied to the generator to balance the centripetal forces and aerodynamic lift and drag generated by the rotor (8) in use to achieve a desired degree of rotor coning.
Patent NZ-536717-A (NZ)
Title: A device for, and method of, supporting a glass panel for forming a frameless glass panel fence
Inventor: AUSTIN WAYNE
IPC: E04F11/18
Filed: 2003-04-23
Abstract: A glass panel support includes an a threaded anchor rod 50 that is embedded in epoxy grout in a hole 70 in the sub-floor and a mounting member 60 that is screwed down onto the anchor rod to be mounted at the desired height with respect to the sub-floor. The glass panel can then be inserted into the slot 62 in the upper portion of the mounting member 60 to rest on the plastic compression block 74 and locked to the mounting member by bolts 76 which pass through holes in the panel and thread into the other side of the mounting member. Plastic spacers 78 of different thicknesses permit lateral adjustment of the panel position when locked into the mounting member. Once the panel is set in place across several of the mounting members to form a fence, the holes in the sub-floor can be grouted to the surface of the sub-floor.
Patent NZ-539333-A (NZ)
Title: Boronic acid salts and their use in the treatment of thrombosis
Inventor: MADGE DAVID JONATHAN
IPC: C07F5/02
Filed: 2003-09-09
Abstract: Disclosed is a pharmaceutically acceptable base addition salt, other than a multivalent metal salt, of a boronic acid of formula (I) wherein: Y comprises a hydrophobic moiety which, together with the aminoboronic acid residue -NHCH(R9)-B(OH)2, has affinity for the substrate binding site of thrombin; and R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of O and C atoms is 3, 4, 5 or 6 or R9 is -(CH2)m-W where m is 2, 3, 4 or 5 and W is -OH or halogen; and when YCO- is an optionally N-terminally protected dipeptide residue, the peptide linkages in the acid are optionally and independently N-substituted by a C1-C13 hydrocarbyl group optionally containing in-chain or in-ring N, O or S and optionally substituted by a substituent selected from halo, OH and trifluoromethyl. Also disclosed is an oral medicament comprising a salt of a boronic acid which is a selective thrombin inhibitor and has a neutral aminoboronic acid residue capable of binding to the thrombin S1 subsite linked through a peptide linkage to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites, the salt comprising a boronate species derived from the boronic acid and a cation other than a multivalent metal action having a valency n and having an observed stoichiometry consistent with a notional stoichiometry (boronic acid:cation) of n:1. Compounds and medicaments of the type disclosed are useful for treating thrombosis by way of prophylaxis or therapy.
Patent NZ-554464-A (NZ)
Title: Containment pens for finfish aquaculture
Inventor: PAGE STEPHEN H
IPC: A01K61/00
Filed: 2005-10-28
Abstract: A containment pen for finfish aquaculture, comprising a supporting structure, a net attached to the supporting structure and defining a containment volume of sufficient size for swimming finfish, wherein the net comprises a plurality of removable net panels, wherein each of the removable net panels comprises a discrete piece of flexible netting attached along its perimeter to one or more substantially rigid beams, and wherein the removable net panels are configured to be removable from the containment pen with the piece of flexible netting remaining attached to the substantially rigid beams. The plurality of removable net panels provides the supporting structure for a majority of the containment pen and adjoining net panels are attached by attaching together adjoining beams, and the panels are shaped so that a beam of one panel extends generally parallel to and adjacent a beam of an adjoining panel.
Patent NZ-556284-A (NZ)
Title: Method for prognosis or selection of treatment of cancer comprising detecting expression of EphB2
Inventor: JUBB ADRIAN M
IPC: C12Q1/68
Filed: 2006-01-05
Abstract: Disclosed is a method for prognosis of cancer in a human patient, the method comprising: (a) detecting expression of EphB2 in a biological sample from the patient, and in a control sample; (b) comparing expression of EphB2 in the biological and control samples; and (c) predicting cancer prognosis of the patient based on the comparison in (b), wherein increased EphB2 expression in the patient biological sample relative to a control sample is prognostic for cancer in the subject.