Patent SG-11201908945R-A (SG)
Title: Compounds that inhibit mcl-1 protein
Inventor: HARRINGTON PAUL E
IPC: A61K31/553
Filed: 2018-03-28
Abstract: IVA R ea R e R e RZ; Rea ,S0 e NR 3 0 \ R 2 R 2 c R 2 B IR 9A R (I) R\"A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit °nolo HE mil um °nom° oimIE (10) International Publication Number WO 2018/183418 Al co co 00 O C (51) International Patent Classification: C07D 498/08 (2006.01) A61P 35/00 (2006.01) A61K 31/553 (2006.01) A61P 35/02 (2006.01) (21) International Application Number: PCT/US2018/024723 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,171 30 March 2017 (30.03.2017) US 62/479,230 30 March 2017 (30.03.2017) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). (72) Inventors: HARRINGTON, Paul E.; 2330 Gillingham Circle, Thousand Oaks, California 91362 (US). ASHTON, Kate; 30948 Minute Man Way, Westlake Village, Califor- nia 91361 (US). BROWN, Sean P.; 28909 Hollowbrook Ave., Agoura Hills, California 91301 (US). KALLER, Matthew R.; 1644 Red Rock Avenue, Ventura, California 93004 (US). KOHN, Todd J.; 2966 Eagles Claw Avenue, Thousand Oaks, California 91362 (US). LANMAN, Brian Alan; 6000 De Soto Avenue #305, Woodland Hills, Cali- fornia 91367 (US). LI, Kexue; 274 Via Antonio, Newbury Park, California 91320 (US). LI, Yunxiao; 2462 Pleas- ant Way, Unit P, Thousand Oaks, California 91362 (US). LOW, Jonathan D.; 19355 Sherman Way #39, Reseda, California 91335 (US). MINATTI, Ana Elena; 1616 S. Crescent Heights Blvd., Los Angeles, California 90035 (US). PICKRELL, Alexander J.; 30948 Minute Man Way, Westlake Village, California 91361 (US). STEC, Markian M.; One Amgen Center Drive, Thousand Oaks, California 91320 (US). TAYGERLY, Joshua; 213 Acadia Street, San Francisco, California 94131 (US). (74) Agent: FRIEDRICHSEN, Bernard P.; AMGEN INC., Patent Operations M/S 35-1-B, One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMPOUNDS THAT INHIBIT MCL-1 PROTEIN (57) : Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharma- ceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (I), or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. [Continued on next page] WO 2018/183418 Al MIDEDIMOMOIDEIREEMOMMENIVEHIMEN Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))