Patent SG-11201810023Q-A (SG)
Title: Anti-tim-3 antibodies and methods of use thereof
Inventor: VAN DIJK MARC
IPC: C07K16/28
Filed: 2017-05-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H1110111111111111111111111111110110101111110011111011101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\") WO 2017/205721 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: achusetts 02149 (US). UNDERWOOD, Dennis John; 28 C07K 16/28 (2006.01) A61K 39/00 (2006.01) John A Andrew Street, Boston, Massachusetts 02130 (US). (21) International Application Number: (74) Agent: WILKINS, Andrew T. et al.; Lathrop & Gage LLP, PCT/US2017/034645 28 State Street, Suite 700, Boston, Massachusetts 02109 (22) International Filing Date: (US). 26 May 2017 (26.05.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/342,610 27 May 2016 (27.05.2016) US HR, KW, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/420,276 10 November 2016 (10.11.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: AGENUS INC. [US/US]; 3 Forbes Road, Lex- PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, ington, MA 02421 (US). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (72) Inventors: VAN DIJK, Marc; Gaailaan 16, 3722ZH TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Bilthoven (NL). BREOUS-NYSTROM, Ekaterina (84) Designated States (unless otherwise indicated, for every Vladimirovna; Waldenburgerstrasse 15, 4052 Basel (CH). kind of regional protection available): ARIPO (BW, GH, — WILSON, Nicholas Stuart; 68 Electric Avenue, Apart- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ment 1, Somerville, Massachusetts 02144 (US). WAIGHT, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Jeremy Dale; 25 Charlton Street, Apt. 403, Everett, Mass- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = _ _ (54) Title: ANTI-TIM-3 ANTIBODIES AND METHODS OF USE THEREOF = Figure 4 = _ Binding to human CD8+ T cells = = = = 2000 -®- lsotype control = = .,, -40- pab2085 (IgG1) = 1500 — V.. -.-- pab2184 (IgG1 variant) 40,... -6-- pab2186 (IgG1 variant) = = LE- - 8 - pab2187 (IgG1 variant) 2 1000 -v--- pab2188 (IgG1 variant) = - pab2189 (IgG1 variant) --ar. pab2190 (IgG1 variant) — = 500 -Y- pab2191 (IgG1 variant) -kr pab2192 (IgG1 variant) 4-- -- '5 4 0—, 0. 11, x0 0 — 1-1 -4 1 1-1 ei Antibody concentration ( lginil [log]) IN kr) 0 ei ----- (57) : The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 IN , I function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expres- 0 sion vectors and host cells for making these antibodies, and methods of treating ei a subject using these antibodies. O [Continued on next page] WO 2017/205721 Al MUM 31010101IMMEMODIMIIMINEilin#011 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.170) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(U)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))