baber/WOPTO huggingface dataset:
Patent PT-951481-E (PT)
Inventor: SCHUBERT WALTER DR
IPC: A61K38/00
Filed: 1997-12-10
Abstract: It has been discovered that, in the case of amyotrophic lateral sclerosis, usually a lethal motoneuron disease, a large number of the immune system cells expressing receptors (Fc receptors) of immunoglobulins (IgC), preferably immunoglobulins of classes 1 and 3 (Fc gamma RIII receptors for IgG1 and IgG3) can be found in the blood stream. Selective destruction or functional obstruction of these cells can be achieved in order to treat amyotrophic lateral sclerosis (ALS) with the following substances, or their preparations ( in the form of intravenous applications or preparations), individually or in combination: a) antibodies, preferably monoclonal antibodies, which bind to Fc gamma RIII receptors, inactivate said receptors or individual species of this receptor family or cause the destruction of cellular forms containing said receptors, and/or are coupled to other cytotoxic substances, b) soluble Fc gamma  receptors, preferably soluble Fc gamma RIII receptors which bind to immunoglobulins, preferably G immunoglobulins  of under-class 1 (IgG1) and/or 3 (IgG3), c) the protein V which bind to immunoglobulin G, obtained from Gardnerella vaginalis, and d) antisense RNA molecules which bind specifically to mRNA sequences of Fc gamma  receptors, preferably to those PF Fc gamma RIII receptors.
Patent PT-1071747-E (PT)
Inventor: BAUR MARKUS
IPC: A61L27/00
Filed: 1999-04-07
Abstract: An human keratinocyte cell line immortalized by means of at least one functional tumor gene of retroviral origin characterised in that it is (1) non-tumorigenic, (2) conserves the capacity for differentiation and for the expression of proteins and of enzymes expressed by normal differentiated keratinocytes even after an elevated number of passages in culture, and (3) forms a stratified and polarised epithelium having a stratum corneum ortho-keratinocyte, if cultivated in an organo-typical culture in a medium without serum and without a layer of nourishing cells. An improved process to immortalize human skin cells to obtain immortalized keratinocytes is characterised in that it comprises the following steps: (i) isolating a sample of human skin; (ii) preparing the sample of skin for in vitro culture; (iii) obtaining keratinocytes from this prepared sample of human skin and seeding in a growth medium without serum with said keratinocytes, on culture plates provided with a coating comprising fibronectin, collagen type I and SAB, which facilitate the fixation and the growth of cells; (iv) replacing the medium in a way sufficient to obtain an optimal confluent growth of cells in culture, continuously maintaining the coating of the plate; (v) transferring keratinocytes into a selection medium without serum on culture plates coated previously in a similar manner; (vi) infecting keratinocytes using functional tumor genes of at least two different retrovirus; (vii) transferring the resulting immortalized keratinocytes to a proliferation medium suitable for the proliferation of immortalised keratinocytes on culture plates coated in a similar way; (viii) transferring the resulting proliferated keratinocytes into a differentiation medium having a high content of calcium on culture boxes coated in a similar way. Use of keratinocytes for immunological, pharmacological, photo- and chemical-toxigological analyses of skin reaction and for expression of heterologous genes and for the construction of artificial skin.
Patent PT-1107974-E (PT)
Inventor: FINKELSTEIN NINA
IPC: C07F9/38
Filed: 1999-08-27
Abstract: New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.
Patent PT-1121501-E (PT)
Inventor: REITZ REINHOLD
IPC: E05B15/00
Filed: 1999-10-14
Abstract: A handle (10) supported pivotably but axially tight on an installation body (20) has a polygonal bar (30) mounted for rotation within a handle neck (12) for actuating a closing mechanism. Two drivers (15, 35) movable relative to each other are engageable in a non-positive and/or a positive way between neighboring surfaces (17, 37) either directly or by means of coupling elements (36, 40, 42) so that a torque transmission from the handle (10) to the polygonal bar (30) is free but is blocked from the polygonal bar (30) to the handle (10) as at least one coupling element (36) is displaced in the direction of the attack. A main portion of a polygonal driver (35) may be concentrically enclosed by a two-shell handle driver (15) having wings (52) with front faces (19) which drive e.g. pairs of spring-loaded roller pins (36) held in a wedge-shaped confining zone (55). Corner areas of indentations (31) of the polygonal driver (35) serve to attack the roller pins (36). Central parts (50) of the handle driver (15) may guide a compression spring (38) which loads engaging balls (47) in an outward direction; recesses (27) of the installation body (20) are associated to the balls (47) at enclosing surfaces (24; 44).
Patent SG-16993-G (SG)
Title: External feminine protection device with skid-resistant coating for holding the device in place
IPC: A61F13/15
Filed: 1993-02-16
Abstract: The invention is generally accomplished by providing a pad for human exudate that is provided with a coating material that has a high coefficient of friction. Among the preferred coating materials are the materials formed from modified acrylics. The materials preferably have a coefficient of friction of greater than 1 and a Sheffield smoothness rating of greater than 200 when utilizing a modified ASTM test.
Patent SG-44582-G (SG)
Title: Vibrator unit
IPC: H03H3/02
Filed: 1982-09-11
Abstract: The piezoelectric crystal vibrator, operating by thickness shearing, comprises a vibrating portion (1) provided with a plurality of electrodes (A1, A2) and a support portion (3) formed jointly with this vibrating portion. The support portion is formed as a single body with the vibrating portion and it has the shape of a "haft" extending outwards, laterally, from the ends of the vibrating portion. This vibrator is of high accuracy in frequency, small bulk and can be manufactured easily. It applies in a particularly advantageous manner in an electronic watch in the guise of reference element of standard frequency. <IMAGE>
Patent IE-38762-L (IE)
Title: Encapsulated drops of fruit material
IPC: A23L21/18
Filed: 1974-01-17
Abstract: 1484562 Encapsulation process UNILEVER Ltd 21 Jan 1974 [23 Jan 1973] 3334/73 Heading B8C [Also in Division A2] Encapsulated liquid droplets are produced by coating droplets of an aqueous fruit material containing dissolved calcium or aluminium ions with an aqueous alginate or pectate sol as the droplets are formed and the coated droplets are then contacted with an aqueous solution containing dissolved calcium or aluminium ions whereby the liquid droplets become coated with a shell of calcium or aluminium alginate or pectate. Suitable apparatus for carrying out the process is shown in the figure wherein the liquid to be encapsulated is led through the inner tube 1, 2, suitably with the assistance of an oscillating air pressure delivered via the tube 4, alginate or pectate sol is led to the zone 7 via tube 8 so that droplets emerging from the end 3 of tube 1, 2 become coated therewith and fall directly into the bath 9 containing Ca<SP>++</SP> or A1<SP>+++</SP> ions.
[GB1484562A]
Patent IE-44866-L (IE)
Title: Halogenated-16ó-methylpregnanes
IPC: C07J43/00
Filed: 1977-03-02
Abstract: 1530975 9,11 - Dihalo - 16 - methyl steroids ROUSSEL UCLAF 2 March 1977 [2 March 1976] 08713/77 Heading C2U The invention comprises compounds of formula (wherein L is H or C 1-18 acyl, and either X is Cl or Br and Y is Cl, or X is Cl and Y is F); and their preparation from the corresponding 9(11)- enes by halogenation, e.g. with an N-X-succinimide or -acetamide in conjunction with HY or LiY, optionally followed by acylation/deacylation interconversions at C-21. Topical anti-inflammatory compositions comprise a compound I and a carrier.
[GB1530975A]
Patent IE-39182-L (IE)
Title: Fertilizer
IPC: C09K17/52
Filed: 1974-03-15
Abstract: Agents for improving the soil and/or manuring arable land contain flue dust. The flue dust can be applied alone, in combination with lime (wt. ratio 1:1-10, esp. 1-4), in combination with a fertiliser (e.g. an NPK, PK or P fertiliser or stable manure), or as a filler in a pesticide compsn. The application rate for moist flue dust (bulk density ca 1.4 tonne/m3) is pref. 0.2-10 (1.5, esp. ca 2) tonne/ha.
[FR2221076A1]
Patent IE-790571-L (IE)
Title: Machine for forming heads on shanks
IPC: B21K1/46
Filed: 1979-08-08
Abstract: A machine for forming heads on shanks, in particular nail heads, where the shanks are temporarily secured in a preferably rotary tool defining wholly or partially the shape of the heads and co-operating with a rotary roll. According to the invention at least one roll is adapted for internal rolling with respect to one or more of rings serving as tools, the shanks being located substantially radially in said rings.
[US4309885A]
Patent IE-45189-L (IE)
Title: Trans-hexahydro-pyrido-indoles
IPC: A61P25/20
Filed: 1977-04-06
Abstract: Certain 2-substituted trans-hexahydropyridoindoles are useful as major tranquilizers in warm-blooded animals or are useful as intermediates for producing such major tranquilizers.
[US4141980A]
Patent IE-34326-L (IE)
Title: Amides of phenylaminoethanol
IPC: A61K31/60
Filed: 1970-06-24
Abstract: 1,266,058. Salicylamide derivatives. ALLEN & HANBURY'S Ltd. 29 June, 1970 [8 July, 1969], No. 34379/69. Addition to 1,200,886. Heading C2C. Novel salicylamide derivatives of the Formula VI: in which R<SP>2</SP> is an arylalkyl group, the alkyl portion of which contains 1 to 6 carbon atoms and the aryl portion of which may be substituted by one or more alkoxy or hydroxy radicals, or an aryloxyalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms, and the aryloxy portion of which is substituted by one or more alkoxy or hydroxy radicals, R<SP>3</SP> is H and X is CONH 2 , and physiologically acceptable acid addition salts thereof are prepared by (1) reducing compounds of Formula V: in which X is CONH 2 or a group convertible thereto, B<SP>2</SP> is H, benzyl or as defined above, and R<SP>3</SP> is H or benzyl, in which the phenolic hydroxy group may be protected to convert the CO group to CHOH, if necessary with subsequent conversion of X to CONH 2 and R<SP>2</SP> and R<SP>3</SP> to arylalkyl or aryloxyalkyl and hydrogen, respectively, and subsequent removal of any protective groups; (2) reacting compounds of Formula VI above in which X is CONH 2 and R<SP>2</SP> and R<SP>3</SP> are both H with the appropriate aldehydes or ketones and reducing the resulting azomethines; (3) reductively alkylating compounds of Formula VI in which X is CONH 2 and RQ and R<SP>3</SP> are both benzyl with the appropriate carbon compounds; and (4) reducing the azomethines obtained by reacting the appropriate glyoxals with amine of the formula R<SP>2</SP>NH 2 . 5 - [1 - Hydroxy - 2 - (1 - methyl - 3 - phenylpropylamino)-ethyl]salicylamide hydrochloride is separated into two racemic modifications by treatment with benzoic acid, separating and then hydrolysing the resulting benzoates. 5 - [N - Benzyl - N - (1 - methyl - 3 - phenylpropyl) - glycyl] salicylamide hydrochloride is obtained by reacting 5-bromoacetylsalicylamide with N benzyl - N - (1 - methyl - 3 - phenylpropyl) amine. 5 - (2 - Amino - 1 - hydroxyethyl) salwylamide hydrochloride is obtained by treating 5-(2-amino- 1-hydroxyethyl) salicylic acid methyl ester hydrochloride with ammonium hydroxide. 5 - [1 - Hydroxy - 2 - (1,1 - dimethyl - 3 - phenylpropylamino)ethyl]aalicylic acid methyl ester hydrochloride is made by hydrogenating the imine resulting from the reaction between 5- glyoxyloyl-salicylic acid methyl ester hydrate and 1,1-dimethyl-3-phenylpropylamine. Pharmaceutical compositions, having the ability to block both α- and #-adrenergic receptors and suitable for oral, rectal or parenteral administration, contain the above novel compounds or pharmaceutically acceptable acid addition salts and non-toxic carriers.
[GB1266058A]
Patent IE-820927-L (IE)
Title: Carbonating liquids
IPC: B01F3/04
Filed: 1982-04-20
Abstract: An apparatus for carbonating liquids is mounted on the inside of the door (1) of a domestic refrigerator, and a control lever (76) on the outside of the door is operable to control (i) the supply of water from a reservoir tank (7) to the carbonating chamber (8), (ii) the supply of gas from a cylinder (37) to the carbonating chamber for injection into the water, (iii) the operation of an exhaust valve to release the gas pressure in the carbonating chamber (8), and the discharge of carbonated water from the chamber (8) to a nozzle (21) on the outside of the refrigerator door. Water flows into and out of the chamber through a single port in the base of the chamber which houses a spool valve reciprocable in opposite directions to connect the port to the reservoir tank (7) and to the discharge nozzle (21). <IMAGE>
[GB2097274A]
Patent IE-35466-L (IE)
Title: Food storage containers
IPC: B65D85/72
Filed: 1971-07-21
Abstract: A food container having an injection moulded polypropylene body with an open end around which extends a circumferential flange to which a metal lid having a frusto-conical annular wall is attachable. The walls of the container are tapered in thickness near the open end to accommodate the outwardly flaring frusto-conical wall so that the wall can provide suitable support for the container wall during a seaming operation where the lid is seamed to the flange by means of a conventional tin can seaming machine.
[US3709399A]
Patent IE-36543-L (IE)
Title: Recovering flavouring substances.
IPC: A23L27/24
Filed: 1972-07-06
Abstract: 1389260 Recovering flavouring substances TOBACCO RESEARCH & DEVELOPMENT INSTITUTE Ltd 3 July 1972 [6 July 1971 31 Jan 1972] 30976/72 Heading C6E A vegetable material is pulped and water is added, then the sugar content is determined and, if necessary, sugar is added to a level suitable for fermentation to proceed and the mixture is fermented with an alcohol producing yeast culture and the off gases are passed through activated carbon to sorb the flavouring substances which are recovered by desorption. Desorption may be achieved using steam, ethanol vapour or liquid, a gas inert to the system, or application of a vacuum. The vegetable material may be spices, fruit, fruit rinds, flowers, berries, beans or seeds, herbaceous parts of plants, or substances extracted from plants.
[GB1389260A]
Patent FI-811305-L (FI)
Inventor: ROKACH JOSHUA
IPC: C07D417/04
Filed: 1981-04-27
Abstract: 7-Fluoro-dibenzo[b,f]thiepin derivatives of formula: <CHEM> -in which n is 0, 1, 2, 3 or 4; Z is thio, sulfinyl, or sulfonyl; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-2,5-dioxo- DELTA <3>-pyrrolin-3-yl, or -CO-R2, where R2 is hydroxy, lower alkyl, lower alkoxy, amino or 2-amino-3-methylthiazoline, or certain substituted amino or lower alkoxy radicals, and the dotted line indicates either an olefinic bond or saturation at the 10,11-position; and the pharmaceutically acceptable salts thereof are novel. They are used in the treatment and control of allergic conditions such as allergic asthma and are made into pharmaceutical compositions for this purpose. Certain specific derivatives, for example, 7-fluoro-dibenzo-[b,f]thiepin-3-carboxylic acid-5-oxides, exist as racemic mixtures and are readily into the respective enantiomers one of which possesses greater bioactivity than the racemic mixture from which it is derived. The compounds are prepared by a number of suitable methods, including hydrolysis of the corresponding 3-cyano compounds and dehydration of a corresponding 11-alcohol to form the 10,11-unsaturated compound.
Patent IE-791026-L (IE)
Title: Cephalosporin derivatives.
IPC: C07D501/22
Filed: 1979-08-08
Abstract: Cephalosporin antibiotics of general formula (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group) exhibit broad spectrum antibiotic activity, particularly high activity against members of the Enterobacteriaceae, The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I), Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics,
[CA1130279A]
Patent IE-811160-L (IE)
Title: Self-trimming photosensitive layer
IPC: G03F7/16
Filed: 1981-05-25
Abstract: A thin photosensitive layer which upon lamination to a substrate is self-trimming at the edges by the application of a tensile stress transverse thereto, comprising (a) monomer (b) initiator system and (c) binder comprising a continuous major phase of polymer and a discontinuous minor phase of non-fibrous solids.
Patent IE-861401-L (IE)
Title: Detecting oxygen in food
IPC: G01N31/22
Filed: 1986-05-27
Abstract: The present invention relates to compositions useful for the detection of oxygen in a humid medium, characterized in that they comprise at least one complex of the formula (LMX)n in which the ligand L is selected from among the groups:   <IMAGE>    <IMAGE> <IMAGE>  where: R represents Cl,Br,NO2,C1-4-alkoxyl, C1-4-alkyl, m and p are comprised between 0 and 3, q is comprised between 0 and 2, the substituent R on the pyridine nuclei never occupying a position neighboring the nitrogen atom, X=Cl,Br,I,NO3,C104, M represents Cu or Mn, and n is equal to 1 or 2, as colored indicator of the presence of oxygen in a humid medium, in solution in an acceptable solvent. The present invention also relates to a process for preparing such compositions, and detectors of the presence of oxygen comprising them.
Patent IE-891871-L (IE)
Title: Portable radiotelephone with control switch disabling
IPC: H04B1/3827
Filed: 1989-06-12
Abstract: A portable radiotelephone with control switch disabling is disclosed. A flip element (104) which contains a microphone and covers a keypad (110) and other control buttons when in a closed position also activates a hookswitch (306). When the hookswitch and microprocessor indicate that the flip element is in a closed position, the on/off switch cannot be activated to turn the portable radiotelephone on or off and switches which control volume level are deactivated.
Patent IE-811901-L (IE)
Title: Steroid compositions
IPC: A61K31/565
Filed: 1981-08-19
Abstract: The present invention provides zootechnic and/or veterinary compositions which afford excellent results with the growth of pigs, in particular with respect to gain in weight. The compositions of the invention comprise from 10 to 50 mg of zeranol and from 5 to 50 mg of a steroid of the general formula: <IMAGE> wherein R represents an alkyl radical of from 1 to 3 carbon atoms and X represents a hydrogen atom, an acyl radical of from 1 to 18 carbon atoms, a saturated or unsaturated hydrocarbyl radical of from 1 to 6 carbon atoms, or a saturated or unsaturated hydrocarboxyhydrocarbyl radical of from 2 to 5 carbon atoms.
[GB2082065A]
Patent IE-832159-L (IE)
Title: Dispenser package
IPC: B65D75/58
Filed: 1983-09-14
Abstract: A dispenser package (10, 100) for flowable substances of the type where the flowable product is contained within a flexible pouch (22) adhered to a relatively stiff material (12) and may be opened along a fault line (24) or cut pattern scored in the relatively stiff material with one hand by folding the stiff ends towards one another into a "V" shape containing one or more dimples, pyramidal shapes (26) or other protrusions on the fault line (24) or fault area. The protrusions (26, 40, 52, 54, 56) not only increase and concentrate the stress forces, so that even very tough, high barrier materials may be used in constructing the package and will rupture at the protrusions by the aforesaid folding motion, but also control both the aperture shape and flow direction of the flowable substance as it is dispensed. The ability to make the package of tough materials enables the package to contain substances under pressure which subsequently will be dispensed. A sponge-like material (65, 70) also may be compressed within the package shaped so that a ' portion (66) will project from the package on opening for use as a swab for application of the contents.
Patent IE-40092-L (IE)
Title: Electrolysis electrode
IPC: C25B11/08
Filed: 1974-10-28
Abstract: A metal electrode with an active cover layer for electrochemical purposes which cover layer includes metal platinates, metal palladates, or the like, and metal palladates and comprises, as embedding substances compounds of the type Ba (MxTi1-x)O3 where M is a platinum metal. The latter may be used alone or in combination with other additives and does not impair on the one hand the effectiveness of the active materials and is on the other hand, when exposed to an electrolytic bath, location in chemically resistant without showing complete inactivity and, thus, increase the current yield of the anode.
[US3992280A]
Patent IE-802443-L (IE)
Title: Self-drilling screw
IPC: F16B25/10
Filed: 1980-11-25
Abstract: A rotary milling cutter 50, for fluting a drill screw shank, has a plurality of peripherally positioned cutting teeth 52, the outer extremity of each of said teeth 52 being formed as a semicircle 54 with a rib 56 formed thereon and each of said ribs 56 having an arcuate configuration whereby, in use, the drill screw shank is shaped to present a flute 16, 18 having at least one longitudinally-extending chip-breaking trough 46, 48. <IMAGE>
[GB2101022A]
Patent IE-40279-L (IE)
Title: Ring traveler for yarn twister
IPC: D01H7/60
Filed: 1974-12-05
Abstract: Generally C-shaped ring travelers, designed for movement along the inside of a ring of a yarn twister or like machine and having, for the purpose of minimizing aerodynamic resistance, overall drop-shaped or streamlined cross-sectional contours at all essential transverse planes, are disclosed. The cross-sectional configuration is characterized by an oblong shape having a relatively wider or blunt leading edge and a relatively narrower or less blunt trailing edge. The foot of the traveler has a pair of laterally offset, generally vertical guide surfaces, which face outwardly of the ring and are somewhat convexly shaped to a degree approximating the ring curvature, for engaging the inside edge of the ring flange and the inside face of the web of the ring, and bridging the space between those surfaces a generally horizontal guide surface for engaging the underside of the inner ring flange. The latter guide surface is somewhat gabled to enhance the stability of the traveler when in motion by providing for a planar rather than a line contact between the traveler and the underside of the ring flange.
[US3961470A]
Patent IE-43672-L (IE)
Title: Device for moving heavy objects
IPC: B60B33/00
Filed: 1976-11-18
Abstract: 1515085 Moving furniture; castors BRABY GROUP Ltd 9 Nov 1976 [12 Feb 1976] 5587/76 Addition to 1350507 Heading A4U [Also in Division B8] The device of the Parent Specification is modified in that the roller spindle at one end of the device is supported in spaced deformable flanges of a sub-frame which is mounted to swivel on the main frame to allow steering of the device by means of a stowable handle which when stowed, holds the sub-frame in a straight travel setting.
[GB1515085A]