baber/WOPTO huggingface dataset:
Patent DO-P2006000088-A (DO)
Title: Compuestos utiles en terapia
Inventor: BRADLEY PAUL ANTONY
IPC: A61K31/4152
Filed: 2006-04-11
Abstract: Los compuestos de formula (I), o derivadosfarmacéuticamente aceptables de los mismos, en la que: R1 representa H, alquilo C1_6, alquil C1-6-oxi, cicloalquilo C3_8 o halo; R2 representa H, alquilo C1_6 (opcionalmente sustituido con R3), fenilo (opcionalmente sustituido con CN) o Het; R3 representa OH, CN, Het; -R4-alquilo C1-6 o CONR5R6; R4 representa -CO2- o -0-; R5 y R6 representan independientemente H, alquilo C1-6 (opcionalmente sustituido con OR7) o cicloalquilo C3_8; R7 representa H o alquilo C1-6; Het representa un grupo heterocíclico aromático de cinco o seis miembros que contiene (i) de uno a cuatro heteroátomo(s) de nitrógeno o (ii) uno o dos heteroátomo(s) de nitrógeno y un heteroátomo de oxígeno o uno de azufre o (iii) uno o dos heteroátomos(s) de oxígeno o azufre, estando dicho grupo heterocíclico opcionalmente sustituido con uno o más grupos seleccionados entre CN y alquilo C1_6; R8 representa alquilo C1_6, alquil C1_6-oxi, cicloalquilo C3_8 o halo; R9 y R10 representan independientemente H, alquilo C1_6, alquil C1_6-oxi, CN, CF3 o halo; pueden ser útiles para tratar endometriosis, fibroides uterinos (leiomiomata), menorragia, adenomiosis, dismenorrea primaria y secundaria
Patent DO-P2010000130-A (DO)
Title: Combinacion de un gestageno y un estrogeno y uno o varios excipientes/portadores farmaceuticamente aceptables para ser aplicada como anticonceptivo para la anticoncepcion oral sin lactosa
Inventor: FRICKE SABINE
Filed: 2010-05-05
Abstract: Los gestàgenos, con preferencia dienogest, acetato de clormadinona o levornogetrel en combinación con estrógenos tales como, por ejemplo, etinilestradiol, 17?-estradiol o valerato de estradiol y uno o varios excipientes/portadores farmaceuticamente aceptables realizan una anticoncepción oral sin lactosa. Se da una posibilidad para mejorar la prevención de la intolerancia a la glucosa en un factor que eventualmente contribuye con la mejoria, incluso en cuanto a costosos ensayos de la intolerancia a la glucosa. La invención tambien es apropiada para un use prolongado.
Patent DO-P2020000112-A (DO)
Title: Derivado de oxi-fluoropiperidina como inhibidor de quinasa
Inventor: NAM YOUN KIM
IPC: C07D487/04
Filed: 2020-06-10
Abstract: La presente invención se refiere a un compuesto representado por la siguiente Fórmula Química 1, o una sal farmacéuticamente aceptable del mismo, y el compuesto según la presente invención puede usarse de manera útil para la prevención o el tratamiento de enfermedades que se asocian con acciones inhibidoras de quinasa.
Patent DO-P2023000197-A (DO)
Title: Inhibidores de vmat2 y métodos de uso
Inventor: NICOLE HARRIOTT
IPC: A61K31/4745
Filed: 2023-09-18
Abstract: Esta divulgación se refiere en general a los compuestos inhibidores de VMAT2, composiciones y métodos relacionados con ellos.
Patent GB-189703743-A (GB)
Title: Improvements in Bicycles.
Inventor: BLACKMORE THOMAS
Filed: 1897-03-08
Granted: 1898-03-05
Abstract: 3743. Blackmore, T. March 8. Steering-mechanism.-Relates to straight-steering mechanism for cycles. Fig. 1 shows the application to a bicycle. A spring C is secured between two lugs B formed on the bearing-cone A. Its rear end is placed between lugs D formed on a clip secured to the bicycle frame. A pin E prevents the spring being withdrawn from the lugs D. The spring C tends to keep the steering-wheel in the plane of the cycle.
Patent GB-189705258-A (GB)
Title: Improvements in Electrically Propelled Motor Road Vehicles.
Inventor: EPSTEIN LUDWIG
Filed: 1897-02-26
Granted: 1898-02-26
Abstract: 5258. Epstein, L. Feb. 26. Motor road vehicles, electric. This is a vehicle of the kind described in Specification No. 15,564, A.D. 1895. On the flywheel shaft of the motor engine A is secured a toothed wheel a<1> which, when the wheel b is made to gear with it, communicates motion from the engine to the dynamoelectric machine B, the electricity produced being stored in accumulators at the back or back and front of the vehicle. Electricity is produced only when the vehicle is at rest, and is used to work B as an electromotor, when the wheel b is put out of gear with the wheel a<1> and the wheel b<1> made to gear with the wheel c, motion then being communicated from the electromotor to the countershaft C, and thence from the pinions c' by chains to the sprocket-wheels d on the axle of the driving- wheels. The brake on the drum E is controlled by a treadle e. The front wheels F have their axles pivoted on the ends of a cross-bar f, and by moving the handle f<3> both wheels are turned, thus steering the vehicle. In cases where extra power is required, the engine and electromotor may be employed together for propulsion.
Patent GB-189712798-A (GB)
Title: Improvements in or relating to Plectrum Devices for Zithers and other Stringed Musical Instruments.
Inventor: BOULT ALFRED JULIUS
Filed: 1897-05-24
Granted: 1897-07-10
Abstract: 12,798. Boult, A. J., [Jonkhoff, J. A.]. May 24. Guitars, mandolins, zithers, &c.-Relates to the operation of zithers, guitars, and like instruments by means of keys, and to means for clamping the strings. Supported over the strings are bars A, on pins c on which slides C can move. One or more plucking-levers d are pivoted on each slide, and operated by a rod E connected to one arm of the key G<1>. As a key is depressed the levers D first move into their operative position, as shown in Fig. 3, and the slide C carrying the levers then moves to the right and the string or strings are plucked, further rotation of the levers being prevented by the rod E engaging with the pins d. As the slide C moves, the dampers H move out of contact with their respective strings, coming back with the slide as the key rises again.
Patent GB-189712915-A (GB)
Title: Improvements in or relating to Horse Shoes.
Inventor: GAITZSCH KARL JULIUS
Filed: 1897-05-25
Granted: 1897-08-28
Abstract: 12,915. Gaitzsch, K. J. May 25. Roughing; calks.-In order to protect from wear the case enclosing a calk, the calk is formed with two, three, or more corners, so that at least two corners serve to cover the surface of the case. Fig. 6 shows one form, but the shape of the case and calk may be coinsiderably varied. The case is preferably completely closed, except at one side.
Patent GB-189713121-A (GB)
Title: Improvements in and relating to Malt Kilns.
Inventor: TOEPFER PETER GEORGE
Filed: 1897-05-27
Granted: 1897-07-03
Abstract: 13,121. Toepfer, P. G. May 27 Malt kilns.-Relates to dumping-trays for malt kilns so constructed that the pressure of the malt causes the trays to be flush with each other until they are released. The trays, with their supports, are shown in plan in Fig. 1 and in side view in Fig. 2. Each tray is supported on trunnions C upon brackets F, each of which is formed with a semicircular channel G. In this channel the rccker H slides, the rocker being formed with the flanges h<1> and h. On the operating-shaft D being turned to dump the tray, the finger X engages with the flange h and causes the flange h<1> to free the edge of the next tray for dumping.
Patent GB-189717680-A (GB)
Title: An Apparatus or Valve for Regulating the Temperature of Water passed through it.
Inventor: WARD HARRY
Filed: 1897-07-28
Granted: 1898-07-28
Abstract: 17,680. Ward, H., and Nock, F. W. July 28. Mixing -valves.-An arrangement of valves for mixing steam with water, and thereby heating the latter, is shown in sectional elevation in Fig. 1. Water is admitted by an inlet band escapes past the screw-down valve p, where it presses down the annular piston g and steam valve h. Steam from the inlet d is thereby admitted into the space m, where it meets the water which has entered round the edges of the annular piston. The heated water passes away from the space m to the outlet f through the perforated sleeve n of the annular piston, and, should cold water only be desired, the valve p is only partially raised to permit water to escape by the opening q to the outlet direct. In a modified arrangement, the steam admission valve is weighted and the screw-down valve is dispensed with.
Patent GB-189724287-A (GB)
Title: Production of Oxyphenyl-guanidines and their Derivatives.
Inventor: MEWBURN JOHN CLAYTON
Filed: 1897-10-20
Granted: 1898-09-17
Abstract: 24,287. Mewburn, J. C., [Chemische Fabrik von Heyden Gesellschaft mit beschrõnkter Haftung]. Oct. 20. Antiseptics ; anaesthetics. - Simple and mixed guanidines of the general formula (in which R and R<11> represent hydrogen, or a fatty or aromatic radicle, and R<1> represents hydrogen, or an alkyl or alkylene), which have a powerful anµsthetic as well as a germicidal action, are produced by causing a carbo-diimide, or materials which yield one, to act upon an amidophenol or an amidophenol ether. The process is carried out by the following methods, viz. :-(1) The reaction products of carbon bisulphide and amidophenol ethers, such as thio-carbamates, thio-ureas, and the like, are treated with desulphurizing-agents, such as PbO, HgCl2, &c., and an amidophenol or ether thereof. The intermediate carbo-diimide, for example, carbo-diphenetyl diimide C(=NC6H4OC2H5)2 may be first isolated as white crystals by adding lead oxide to a solution of diphenetyl thio-urea in benzene, and then passing in gaseous hydrochloric acid. (2) Copper powder is used as desulphurizing-agent, and the amidophenol or its ether is omitted. (3) The reaction products of carbon bisulphide and amidophenols and their ethers are heated alone to 150‹ or 200‹ C, (4) The ureas corresponding to the foregoing thio-ureas are heated with dehydrating-agents, such as caustic alkalies and alkali alcoholates. A large number of new guanidines produced by these methods are mentioned, of which the following are examples, viz. :-o- and p-triphenetyl-guanidine and their homologues, triphenyl-guanidine, diphenyl-monoanisyl - guanidine, and dianisyl - monophenol guanidine.
Patent GB-189727994-A (GB)
Title: An Improved File or Clip for Holding Papers, Samples, and such like.
Inventor: RICHARDSON ARTHUR
Filed: 1897-11-27
Granted: 1898-01-01
Abstract: 27,994. Richardson, A. Nov. 27. Filing papers. - The appliance consists of a circular outer tube b in which slides a pointed wire b<1>. When the file is closed the pointed end of the wire b<1> is pushed into the end a of the tube b. The wire b<1> may have a stud attached to it passing through a slot in the tube b. For small files the bent wire b<1> may be replaced by a piece of spring steel.
Patent GB-189729123-A (GB)
Title: Improvements in the Lags and Pegs used as Pattern Chains in Looms.
Inventor: BURNETT JOHN MASSEY
Filed: 1897-12-09
Granted: 1898-10-08
Abstract: 29,123. Burnett, J. M. Dec. 9. L o o m pattern chains, lags, a n d pegs.-The lags A are made with countersunk holes b to receive the pegs c, which are formed with shoulders d to fit into the countersunk recesses and are held in position by a wire f inserted in the longitudinal groove a through staples e.
Patent GB-189803224-A (GB)
Title: A Device for Separating the Yolk and White of Eggs.
Inventor: GUITERMAN ALBERT LAZARUS
Filed: 1898-02-09
Granted: 1898-09-10
Abstract: 3224. Guiterman, A. L., [Guiterman, H. M.]. Feb. 9. H o l l o w - ware, non - metallic. - A vessel a for separating the white from the yoke of eggs is formed with one or more narrow slits b in the side or bottom.
Patent GB-189804931-A (GB)
Title: Improvements in Stoppers or means of Closure for Bottles.
Inventor: WITTEKIND JULIUS HENRY
Filed: 1898-03-01
Granted: 1898-04-02
Abstract: 4931. Wittekind, J. H. March 1. Stoppers ; refilling, preventing.-Relates to means for preventing bottles from b e i n g fraudulently refilled after they have been once emptied. After the bottle has b e e n filled, the stopper A, B, with its valves and other fittings in position, is inserted in the neck, and secured by the locking-ring K and cement &c. Within the ring, before its insertion, is placed a quantity of fulminate of mercury &c., so that, if it is attempted to forcibly withdraw the stopper, or to destroy the cement by means of acid &c., the fulminate will explode and shatter the neck. The casing which, with its enclosed valves &c., forms the stopper, is made in two parts A, B, screwed together at b, the end a' of the upper part A being formed with ports a for the passage of the liquid, and the bottom part B being formed with a seat b<1> for the heavy valve D. This valve moves between suitable guides, and is normally held on its seat by the spring S, but, if desired, the spring may be omitted. The casing also contains two perforated stops or guard-plates E, F, and a cylindrical plug G, the plug being formed with a seat g for the float valve H. The valves D, H permit the liquid to be poured out, but prevent refilling. The mouth of the bottle is normally closed up by an ordinary cork N.
Patent GB-189805716-A (GB)
Title: Improvements in Pile Fabrics and in their Manufacture.
Inventor: REIXACH JOSE
Filed: 1898-03-08
Granted: 1899-01-21
Abstract: 5716. Reixach, J., and Scott, H. March 8. Pile fabrics.-Plain or figured pile fabrics with pile on both sides are made in a double plush loom by passing the pile warps over picks of weft x, Diagram A, which are thrown on the back of the fabrics and are not interwoven with the ground warps, but are withdrawn after the pile on the face has been cut, half or some of the pile being thereby drawn through to the back, as shown in Diagrams A', A<2>.
Patent GB-189807902-A (GB)
Title: Improvements in and relating to Spring-tyres for Cycles.
Inventor: SIEGRIST HERMANN
Filed: 1898-04-02
Granted: 1898-06-18
Abstract: 7902. Siegrist, H., and Maier, E. April 2. Tyres, elastic other than pneumatic; felloes or rims.-Elastic metal blades or circles D are held within the rim B, the sides of which are inclined as shown to allow the spring D to move inwards, by means of the flanges b of the lateral bands C, which are shaped as shown to engage with the rim and are tightened by bolts E passing through projections p and p<1>. Each band is prevented from turning on the rim by a tenon secured to the rim engaging with a notch in the band. To the outer blade a rubber tyre a is attached. The spring D is sometimes formed of one or more wooden blades.
Patent GB-189810658-A (GB)
Title: Improvements relating to Gypsum or Plaster of Paris.
Inventor: JOHNSON WILLIAM ROBERT
Filed: 1898-05-10
Granted: 1899-04-22
Abstract: 10,658. Johnson, W. R., and Nichols, G. May 10. Calcium sulphate.-Plaster of Paris is recovered from used moulds, or other waste material formed from it, by breaking them into lumps, which are burnt in a kilo, and, after partial cooling, are sprinkled with dilute sulphuric acid. When dry the lumps are ground to powder, which is moderately heated and finally cooled and stored for use. Alum, or sulphate of potash, may be used instead of sulphuric acid.
Patent GB-189817925-A (GB)
Title: A Combined Sideboard or Cabinet and Musical Instrument.
Inventor: WILTON CHARLES
Filed: 1898-08-20
Granted: 1899-05-13
Abstract: 17,925. Wilton, C. Aug. 20. Automatic instruments.-An automatic instrument A is mounted in a cabinet or sideboard as shown.
Patent GB-189819126-A (GB)
Title: Improvements in and connected with Circular Knitting Machines.
Inventor: KERSHAW BINNS
Filed: 1898-09-08
Granted: 1899-06-02
Abstract: 19,126. Kershaw, B. Sept. 8. Circular knitting-machines.-The fabric made on circular knitting-machines is ornamented preferably exteriorly by designs, letters, or marks, &c. as it is made. Troughs e containing colouring-matter in which dip rollers q are arranged on the machine in such a manner that the rollers are rotated by the fabric as it is drawn off. The rollers may be in sections so as to print intermittently, in which case each is provided with a driving-wheel which rubs on the fabric. Bands with or without blocks may be used instead of rollers, or blocks or rollers pivoted and actuated by cams intermittently may be used. The rollers g may be made to shog endwise by a cam to give a zig-zag, or the roller, blocks, &c. may be arranged to rotate relatively to the fabric to produce spirals. The fabric may be drawn over solid colouring-blocks pressed forward by springs or weights.
Patent GB-189824375-A (GB)
Title: Improvements in the Manufacture or Production of Resin Soap.
Inventor: DREHER CARL
Filed: 1898-11-18
Granted: 1899-09-23
Abstract: 24,375. Dreher, C. Nov. 18. Sizes and similar finishes.-Relates to the manufacture of resin soap containing a large proportion of unsaponified resin, for use in sizing paper and for other purposes. The resin is dissolved in phenol or one of its homologues, and is then treated with a solution of sodium carbonate or with a mixture of soda lye and ammonia. Or a resin soap of poor quality may be enriched by the addition of a hot solution of resin in carbolic acid.
Patent GB-189827324-A (GB)
Title: Improvements in Illuminated Clocks.
Inventor: CRANE RICHARD TELLER
Filed: 1898-12-27
Granted: 1899-01-28
Abstract: 27,324. Crane, R. T. Dec. 27. Illuminated clocks ; d i a l s.- The figures of the dial are marked on a transparent ring, and an electric lamp is placed behind each as well as upon the minute-hand. The lamp on the hand is always in circuit, and the others are switched on in succession as the hand travels round. In a modification, the figures may be formed of lamps.
Patent GB-189906502-A (GB)
Title: Improvements in Spray Jets for Liquids.
Inventor: WILSON THOMAS EDWARD
Filed: 1899-03-25
Granted: 1899-04-29
Abstract: 6502. Wilson, T. E., and Kestner, P. March 25. Spray-producers. -A nozzle for producing a spray is formed with two chambers A, B communicating by one or more tangential passages r, which give a rotating motion to the issuing jet, causing it to break up into a spray. A strainer D may be placed in the chamber B as shown in Figs. 3 and 4.
Patent GB-189906944-A (GB)
Title: Improvements in the Manufacture of Fire-resisting and Heat Non-conducting Materials.
Filed: 1899-03-30
Granted: 1900-03-17
Abstract: 6944. Romney, H. R., Thame, J., and Fibrous Materials Syndicate. March 30. Fireproof coverings and compositions.-Relates to the manufacture of non-inflammable material which is also a non-conductor of heat. The refuse of coco-nut husk is combined with fibrous materials such as paper pulp, wood pulp, rag pulp, or asbestos fibre, and mica &c. and magnesium silicate or carbonate, with or without sodium silicate, are added. The materials are intimately mixed in the presence of water, and the mass is moulded to the desired form in perforated moulds under hydraulic pressure. The moulded articles are dried in a current of hot air. When sodium silicate is employed, silica may be liberated by the addition of an acid or carbonate. In the manufacture of coverings for boilers &c., the materials are mixed dry, water or a solution of sodium silicate being added when the material is to be applied to the surface of the boiler &c. A plastic fireproof material may be prepared by saturating coco-nut husk refuse with a solution of sodium silicate and treating with acids or acid salts. The excess of sodium silicate, or the soda salt produced, is removed by filter-pressing or centrifugal extraction, and asbestos fibre is added to the mass. The coco-nut and asbestos fibres are treated together in an opening-machine to thoroughly intertwine them. A small proportion of lime may be added when a hard and porous material is required. The material is applicable for panels to protect ships' bunkers.
Patent GB-189909350-A (GB)
Title: Improvements in Brushing or Scraping and Removing Dusty Deposits and the like.
Inventor: WILTON GEORGE
Filed: 1899-05-03
Granted: 1899-07-22
Abstract: 9350. Wilton, G. May 3. Flues, cleaning.-Relates to brushing or scraping apparatus for removing dust deposits and the like. A brush or scraper is combined with a casing provided with dust and air inlets and connected by flexible tubing to a portable or stationary dust receiver in which a partial vacuum is produced by suitable exhausting-apparatus. Figs. 1, 2, and 3 show various forms of brushes adapted for cleaning flues, chimneys, &c., provided with a casing a' and flexible pipe b, which may be in short lengths with flexible couplings. Fig. 8 shows one form of dust receiver, in which the vacuum is produced by an ejector c and the dust is removed through a trap, while Fig. 9 shows another form with a bellows to force the dusty air through water supplied by a pipe e'. In other forms, the bellows is used with a plain receiver and the ejector with the wet dust-collector. The invention is applicable among other purposes to cleaning flues of kitchen ranges.
Patent GB-189919252-A (GB)
Title: Improvements in Centrifugal Fans and Pumps.
Inventor: DAVIDSON SAMUEL CLELAND
Filed: 1899-09-25
Granted: 1900-08-25
Abstract: 19,252. Davidson, S. C. Sept. 25. Centrifugal pumps.-The invention has reference to the mounting of the blades of fans or pumps having blades of a greater axial length than radial depth, and more particularly to those described in Specification No. 4609, A.D. 1898. In Fig. 2, the blades B are mounted on external angle-iron rings E, which are attached to the hub F by screwed spokes G, by which the fans may be adjusted. The rings may be flat and placed nearer the centre of the blades, or the blades may be mounted on the outside of them. The spokes may be attached to an internal or external central flat ring, and the ends of the blades strengthened by angle-iron rings; or one or more perforated discs may take the place of the central ring and spokes. A central ring carrying the blades may be adjustably attached to the disc. Finally, the ends of the blades may be supported by annular discs on their ends. The long bearings I are supported in the manner described in Specification No. 19,388, A.D. 1898.
Patent GB-189922941-A (GB)
Title: Improvements in Motors for Tools, Stamps, and the like Reciprocating Mechanism.
Inventor: ALBREE CHESTER BIDWELL
Filed: 1899-11-17
Granted: 1900-02-24
Abstract: 22,941. Albree, C. B. Nov. 17. Stamps, ore and like.-Relates to compressed-air and like motors for percussive tools, rock drills, hammers, stamps, and other mechanism. The compressed air &c. acts at high pressure to move the piston in one direction, and then acts expansively for the return stroke. One form of motor is described in Specification No. 22,940, A.D. 1899, and Figs. 4 and 5 show two other forms, with a different arrangement of ports, and in Fig. 5 with two inertia valves M', M<2>, instead of the single valve M, Fig. 4. In the form shown in Fig. 4, the live air enters at B, and, passing through ports H, 5, acts on the area K so as to drive forward the piston E, E<2>, E'. The space A<2> is exhausted through ports J, 0, the central passage of the valve M, port L, space C, and port D. After the valve has been shifted by the impact, the space swept by the shoulder K communicates with the space A<2> through ports 5, 6, the channel in the valve, and ports 7, J, the exhaust port L being closed. The air now acts expansively on the large area of the piston. Springs W, S, S' normally hold the ports ready for starting. In the form shown in Fig. 5, the channel in the piston E, E' is divided into two parts by the plug G<1>, but communication is intermittently made by the channel 4 and port 3. Air at high pressure acts on the area K of the piston, and on the return stroke the air expands against the right-hand end of the piston. The ports are capable of further variation.