baber/WOPTO huggingface dataset:
Patent CA-2888210-A1 (CA)
Title: Methylene linked quinolinyl modulators of ror-gamma-t
Inventor: LEONARD KRISTI A
IPC: A61P29/00
Filed: 2013-10-15
Abstract: The present invention comprises compounds of Formula (I), wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
Patent CA-2888468-A1 (CA)
Inventor: ROHALY JANOS
IPC: H04N1/032
Filed: 2013-10-17
Abstract: Methods of and systems for three-dimensional digital impression and visualization of objects through an elastomer are disclosed. A method of estimating optical correction parameters for an imaging system include pressing an object of known surface topography against an elastomer and imaging a plurality of views of the surface topography of the object through the elastomer. The method also includes estimating a three-dimensional model of the object based on the plurality of views and estimating optical correction parameters based on a known surface topography of the object and the estimated three-dimensional model. The optical correction parameters correct distortions in the estimated three-dimensional model to better match the known surface topography.
Patent CA-2888486-A1 (CA)
Title: Compositions for modulating c9orf72 expression
Inventor: BENNETT FRANK C
IPC: A61K31/7125
Filed: 2013-10-15
Abstract: Disclosed herein are compositions and methods for reducing expression of C90RF72 mRNA and protein in an animal with C90RF72 specific inhibitors. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Such C90RF72 specific inhibitors include antisense compounds. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration C90RF72 specific inhibitors include amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), corticalbasal degeneration syndrome (CBD), atypical Parkinsonian syndrome, and olivopontocerellar degeneration (OPCD).
Patent CA-2890565-A1 (CA)
Inventor: DELORME JOHN D
IPC: A01C15/00
Filed: 2015-05-01
Abstract: Une épandeuse à commande manuelle qui peut être déplacée de larrière sur une surface est particulièrement adaptée pour distribuer du sel et dautres matériaux particulaires qui ont tendance à sagglomérer ou à se regrouper dans une trémie de lépandeuse. Des roues sont montées sur un cadre supportant également la trémie. Un arbre dentraînement horizontal entre les roues est couplé pour faire tourner un arbre vertical. Un distributeur sous la trémie tourne avec une rotation darbre vertical pour distribuer un matériau particulaire qui chute par lintermédiaire douvertures dans le fond de la trémie. Larbre vertical s'étend par lintermédiaire dun trou dans le fond de la trémie et porte au sommet de celle-ci une tarière ayant une aube hélicoïdale. La tarière peut tourner avec larbre vertical lorsque le palonnier est déplacé sur ses roues. La tarière fait circuler le matériau particulaire dans la trémie lorsque lépandeuse se déplace tout en dirigeant le matériau dans la trémie vers le fond de celle-ci.
Patent CA-2890898-A1 (CA)
Inventor: LODA MASSIMO
IPC: C12Q1/68
Filed: 2013-11-08
Abstract: The invention provides methods and products to detect the presence of unidentified high grade prostate tumors in a subject with a Gleason score 7 prostate tumor. The method comprises obtaining a biological sample from a subject in need thereof, measuring a profile of metabolites in the biological sample, wherein the metabolites are differentially expressed in Gleason score 6 versus Gleason score 8 prostate tumors, and classifying the profile of the metabolites to assign a grade to the sample based on the profile of the metabolites.
Patent CA-2891491-A1 (CA)
Inventor: TISCHLER BRIAN J
IPC: A61B17/00
Filed: 2013-11-14
Abstract: A left atrial appendage closure implant (200) may include a support frame (210) including a first bend (240) extending from a proximal collar (212) to a second bend (242), a first segment (270) extending from the second bend (242) to a third bend (244), a second segment (272) extending from the third bend (244) to a fourth bend (246), and a third segment (274) extending from the fourth bend (246) to a distal collar (214), wherein the support frame is actuatable from a first constrained position to a second flowering position to a third mid- deployment position to a fourth unconstrained position. An implant may include a self-expanding support frame having a circumference and a central longitudinal axis, a membrane disposed over at least a portion of the support frame, and a plurality of anchors arranged into a first row and a second row such that the first row and the second row form a staggered pattern about the circumference of the support frame
Patent CA-2892324-A1 (CA)
Inventor: CICERO FRANCESCO
IPC: G06Q40/04
Filed: 2015-05-21
Abstract: Apparatus for stimulating trading in a limited-liquidity financial instrument are provided. One the method may include receiving a trade of liquidity for the limited-liquidity financial instrument. The receiving may include receiving a first order. The first order may correspond to a price and volume associated with a pre-determined bid-offer spread. The order may be executable only in conjunction with a counterorder that trades with the first order and includes a commitment to make a two-way market in the financial instrument at the predetermined bid-offer spread. In certain embodiments, when the first order is received from a first entity and the counterorder is received from a second entity, the method may also include receiving a bid price and an offer price from a second entity.  The method may also include receiving an instruction from the first entity to select one of the bid and the offer and to execute a trade therewith. The execution of the trade may be for a size not less than the pre-determined size. If the system fails to receive a selection from the first entity within a pre-determined period of time, the method may further include executing a trade based on a pre-determined election by the second entity of a default trade direction.
Patent CA-2894964-A1 (CA)
Inventor: LATIMAR IAN
IPC: E21B43/01
Filed: 2013-10-31
Abstract: A subsea connector assembly is provided for automatically coupling a movable subsea structure to a tubular fixed subsea structure. The connector assembly comprises a male connector assembly, removably mountable to the movable subsea structure, and further comprising a throughbore, at least one first actuator member and at least one second actuator member. The connector assembly further comprises an adapter assembly, removably mountable to an end-fitting of a string of tubulars, comprising at least one first engagement member and at least one second engagement member, each of said at least one first and second engagement member are operable to be acted upon by said first and/or second actuator member so as to selectively release a locked engagement with said male connector assembly, allowing said adapter assembly to be moved through said throughbore of said male connector assembly.
Patent CA-2896386-A1 (CA)
Inventor: GRIES BENNO
IPC: C22C1/05
Filed: 2014-01-23
Abstract: The present invention relates to a method for producing sintered spray powders containing chromium nitride, comprising the following steps: a) preparing a powder mixture (A) comprising i) a powder (B) containing one or more components selected from the group consisting of Cr, CrN and Cr2N, and ii) a powder (C) comprising one or more components selected from the group consisting of nickel, cobalt, a nickel alloy, a cobalt alloy and an iron alloy, b) solid phase sintering of the powder mixture (A) in a gas atmosphere containing nitrogen while forming or enriching or stabilizing CrN.
Patent CA-2901991-A1 (CA)
Inventor: SATO KATSUYUKI
IPC: B82Y30/00
Filed: 2014-03-06
Abstract: Fluorine-containing nano-silica composite particles comprising a condensate of a fluorine-containing alcohol RF-A-OH [I] (RF is a perfluoroalkyl group or a polyfluoroalkyl group having a portion of the fluorine atoms thereof substituted with hydrogen atoms, and A is a C1-6 alkylene group) with alkoxysilane and nano-silica particles; and fluorine-containing nano-silica composite particles comprising a condensate of a fluorine-containing alcohol RF'-A-OH [Ia] or HO-A-RF''-A-OH [Ib] (RF' is a linear or branched perfluoroalkyl group including an O, S, or N atom; RF'' is a linear or branched perfluoroalkylene group including an O, S, or N atom; and A is a C1-6 alkylene group) with alkoxysilane and nano-silica particles.
Patent CA-2902198-A1 (CA)
Title: Laboratory testing-based valve prognostics
Inventor: GRABAU TED DENNIS
IPC: G05B23/02
Filed: 2014-03-14
Abstract: The claimed method and system develops a useful lifetime profile for a component of a process control device, such as a valve, and uses that lifetime profile to determine a projected remaining lifetime for the device component in operation. The lifetime profile is developed from using real world operational data of similar process control devices, used under substantially the same operating conditions as to be experienced during operation. Profiles may be developed for numerous device components, from which a projected lifetime profile for the entire process control device is developed. Based on the projected remaining lifetime, notification warnings may be sent to remote computers and maintenance scheduling may be automatically achieved.
Patent CA-2903464-A1 (CA)
Inventor: CHEN LIN
IPC: A61K31/167
Filed: 2014-03-06
Abstract: The present disclosure provides novel methods for treating cancer and conditions regulatable by a transcription factor and/or cofactor using specific compounds, as well as compositions, and pharmaceutical formulations. In certain embodiments, the compounds are transcription factor modulators. Hematological cancer includes leukemia, lymphoma, and myeloma. Leukemia is a type of cancer of blood or bone marrow characterized by an abnormal increase of immature leukocytes. The exact cause of leukemia is unknown; however, it generally results from DNA mutations in stem cells.
Patent CA-2904822-A1 (CA)
Inventor: HANSON BRIAN K
IPC: H01R9/05
Filed: 2015-09-18
Abstract: A grounding block includes a conductive grounding surface configured to electrically ground a wire to a grounded structure, a retention member rotationally fixed about an axis orthogonal to the grounding surface and slideable toward and away from the conductive grounding surface in a direction parallel to the axis, and a biasing element configured to apply a first force to the retention member in the direction toward the conductive grounding surface to electrically ground the wire to the housing to satisfy a first regulatory requirement. A fastener is operative to apply a second force to the retention member in the direction toward the grounding surface to apply a mechanical load to satisfy a second regulatory requirement
Patent CA-2905141-A1 (CA)
Title: Interleukin-2 muteins for the expansion of t-regulatory cells
Inventor: GAVIN MARC A
IPC: C07K14/55
Filed: 2014-03-14
Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
Patent CA-2905469-A1 (CA)
Inventor: GIGLIO LEONARDO ALESSANDRO
IPC: B65D30/08
Filed: 2015-09-29
Abstract: Described herein are embodiments of a pre-formed flexible packaging pouch comprising multiple compartments for storing products. This flexible packaging pouch permits conflicting products, not traditionally packaged together to be sold as one complete, light-weight, flexible unit.
Patent CA-2905668-A1 (CA)
Title: Method and system for determining core losses in a permanent magnet synchronous motor
Inventor: LATEB RAMDANE
IPC: G01R31/34
Filed: 2015-09-25
Abstract: Method and system for determining core losses in a permanent magnet synchronous motor, comprising a measurement of the losses of the motor with the motor not connected to a load, and a deduction of the core losses of the motor from the losses of the motor. The motor is placed in an over-fluxing state during the measurement of the losses.
Patent CA-2905842-A1 (CA)
Title: Compositions et methodes d'expansion de cellule souche epitheliale comprenant un agoniste de wnt et un inhibiteur d'histone desacetylase
Inventor: KARP JEFFREY MICHAEL
IPC: C12N5/02
Filed: 2014-03-11
Abstract: L'invention concerne des solutions de culture cellulaire et des systèmes pour des cultures de cellules souches et d'organoïdes, la formation de structures épithéliales et des utilisations de celles-ci en transplantation. Une couche unique de cellules épithéliales qui s'autorenouvelle activement et qui est organisée en cryptes et villosités revêt l'intestin. Il a été montré récemment que le renouvellement de l'épithélium intestinal est mû par des cellules souches intestinales (CSI) Lgr5+ qui se situent à la base de ces cryptes (Barker et al., 2007). Les cellules souches Lgr5+ peuvent être isolées et cultivées in vitro pour former des organoïdes contenant des structures de type crypte-villosité qui reproduisent l'épithélium intestinal naturel (Sato et al., 2009).
Patent CA-2906413-A1 (CA)
Inventor: STEWART MARK
IPC: B01D33/48
Filed: 2014-03-11
Abstract: A rotary disc filter is provided with an integrated backwash and chemical cleaning system. In one mode of operation, backwash is directed through a control valve to one or more nozzles for spraying the backwash onto the filter media forming a part of a rotary disc filter. In a second mode, a chemical cleaning mode, the pump directs backwash through an eductor that induces a chemical into the inductor which is mixed with the backwash to form a backwash-chemical mixture that is sprayed onto the filter media. A control system is used in conjunction with the backwash and cleaning systems to monitor process information and/or filter media properties and to determine when to perform backwashes and regenerative cleanings in order to optimize the performance of the filter system.
Patent CA-2906773-A1 (CA)
Inventor: MYERS GARRY L
IPC: A61K47/18
Filed: 2014-03-14
Abstract: La présente invention concerne des produits et des procédés pour le traitement de divers symptômes chez un patient, comprenant le traitement de la douleur subie par un patient. L'invention concerne plus particulièrement des formes dosifiées autonomes qui fournissent un agent actif tout en conférant une adhérence buccale suffisante de la forme dosifiée. En outre, la présente invention concerne une forme dosifiée qui est utile pour réduire la probabilité d'abus de détournement de l'agent actif.
Patent CA-2907500-A1 (CA)
Title: Pharmaceutical compositions comprising everolimus
Inventor: DIEDERICH ANKE
IPC: A61K9/28
Filed: 2014-03-19
Abstract: The invention relates to a pharmaceutical formulation comprising 40-O-(2-hydroxy)ethyl-rapamycin in a high drug load part and an immediate release part. In addition, the invention relates to a formulation comprising 40-O-(2-hydroxy)ethyl-rapamycin in a first layer and a surfactant in a layer beneath the first layer. The pharmaceutical composition is particularly suitable for use as a medicament.
Patent CA-2909339-A1 (CA)
Inventor: NAZARIAN BAMSHAD
IPC: E21B41/00
Filed: 2014-04-17
Abstract: A method of Enhanced Oil Recovery from oil zones in a subterranean geological formation, and from oil zones, the method comprising: a first injecting step of injecting a first composition comprising CO2 into the subterranean geological formation for a period of time; a second injecting step of injecting a second composition comprising CO2 and a hydrocarbon into the subterranean geological formation for a period of time, wherein the first composition and the secondcomposition are different; and extracting oil from the subterranean geological formation.
Patent CA-2909806-A1 (CA)
Title: Oral pharmaceutical composition for preventing or treating dry eye syndrome comprising rebamipide or a prodrug thereof
Inventor: CHO EUI-HWAN
IPC: A61K31/4704
Filed: 2014-04-17
Abstract: The present invention relates to an orally administrable pharmaceutical composition for the prevention or treatment of dry eye syndrome, comprising rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof as an active component. Said compound can treat dry eye syndrome through oral administration and is thus safe and convenient to use compared to conventional eye drops.
Patent CA-2909815-A1 (CA)
Title: Systems, methods, and interfaces for aggregating and providing information regarding legal professionals
Inventor: RITCHEY KEVIN L
IPC: G06F17/30
Filed: 2006-01-12
Abstract: The present inventors devised systems, methods, interfaces, and software that can facilitate identification of law firms and/or legal professionals. One exemplary system receives queries from users regarding a legal topic and responds with a listing of attorneys or law firms that are associated with information ranking them based on their experience in handling matters related to the legal topic. The ranking information is based on links between attorneys and public legal documents, such as judicial opinions, court dockets, briefs, litigation documents, journal articles, patents, trademarks, and so forth that mention them by name.
Patent CA-2911123-A1 (CA)
Title: Jet control devices and methods
Inventor: SUPONITSKY VICTORIA
IPC: F15D1/08
Filed: 2013-04-04
Abstract: Examples of a jet control device are described. The jet control device can comprise a jet deflecting member that is configured to intercept and/or collide with a high speed jet emerging from a jet formation location. The interaction of the jet deflecting member and the jet can cause the high speed jet to be dispersed into a plurality of jets with a number of flow directions which may be sideways to an initial direction of the high speed jet. In one embodiment the deflecting member can include a liquid guide formed by injecting a fluid out of an outlet nozzle so that the liquid guide extends longitudinally away from the outlet nozzle. In another embodiment the deflecting member can include an array of solid pellets injected through an outlet in a direction of the emerging high speed jet and configured to collide with the emerging jet thereby deflecting its initial direction.
Patent CA-2913110-A1 (CA)
Title: Systems and methods for improved vessel access closure
Inventor: GINN RICHARD
IPC: A61B17/11
Filed: 2014-06-11
Abstract: Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.
Patent CA-2914490-A1 (CA)
Inventor: PICCIRILLI ANTOINE
IPC: C11B3/06
Filed: 2014-06-04
Abstract: L'invention concerne des procédés d'extraction d'une fraction insaponifiable d'une matière première renouvelable solide, comprenant l'extraction solide-liquide des matières grasses de ladite matière première renouvelable solide en présence d'au moins un solvant organique polaire et d'au moins un cosolvant apolaire non miscible avec ledit solvant organique polaire, conduisant à l'obtention d'une phase organique polaire enrichie en lipides fonctionnalisés par une ou plusieurs fonctions choisies parmi les fonctions hydroxyle, époxyde, cétone, thiol, aldéhyde, éther et amine, et d'une phase organique apolaire enrichie en lipides ne contenant pas ou peu de fonctions hydroxyle, époxyde, cétone, thiol, aldéhyde, éther et amine, puis la concentration des phases organiques.
Patent CA-2915420-A1 (CA)
Inventor: KIM HYEONG WOO
IPC: A61C5/02
Filed: 2013-08-01
Abstract: The present invention provides an endo file for dental endodontic treatment, the endo file including: a head portion inserted into and detachably coupled to a hand piece; a tissue removing portion inserted, from the lower side of the head piece, into a patient' s root canal for removing the nerve of a tooth; and a stress dispersion portion provided between the head portion and the tissue removing portion and having at least one horizontal penetration hole so as to buffer stress concentration generated during the rotation of the endo file, and to minimize endo file breakage.
Patent CA-2916061-A1 (CA)
Inventor: JOUNG HEA-GYOON
IPC: F15B13/043
Filed: 2013-10-31
Abstract: Disclosed are a hydraulic circuit for using a hydraulic fluid in a hydraulic pump in another hydraulic actuator, during levelling and grading work by means of an excavator, and a method for controlling a floating function. A hydraulic circuit for construction machinery having a floating function, according to the present invention, is provided with: two or more hydraulic pumps; a hydraulic cylinder connected to the hydraulic pumps; a boom driving control valve provided on the flow path between the hydraulic pump on one side and the hydraulic cylinder; a boom confluence control valve provided on the flow path between the hydraulic pump on the other side and the hydraulic cylinder; an operating lever; a first sensor for measuring the hydraulic fluid pressure of a large chamber of the hydraulic cylinder; a second sensor for measuring the boom lowering pilot pressure applied to one end of the boom driving control valve; a control valve provided on the flow path between the operating lever and the other ends of the boom driving control valve and the boom confluence control valve.
Patent CA-2916676-A1 (CA)
Title: Polycrystalline ultra-hard material with microstructure substantially free of catalyst material eruptions
Inventor: FANG YI
IPC: C30B33/06
Filed: 2006-12-20
Abstract: Polycrystalline ultra-hard materials and compacts comprise an ultra-hard material body having a polycrystalline matrix of bonded together ultra-hard particles, e.g., diamond crystals, and a catalyst material disposed in interstitial regions within the polycrystalline matrix. The material microstructure is substantially free of localized concentrations, regions or volumes of the catalyst material or other substrate constituent. The body can include a region extending a depth from a body working surface and that is substantially free of the catalyst material. The compact is produced using a multi-stage HPHT process, e.g., comprising two HPHT process conditions, wherein during a first stage HPHT process the catalyst material is melted and only partially infiltrates the precursor ultra-hard material, and during a second stage further catalyst material infiltrates the precursor ultra-hard material to produce a fully sintered compact.
Patent CA-2916752-A1 (CA)
Inventor: FOWLER WILTON L JR
IPC: F21V5/04
Filed: 2009-02-24
Abstract: A lighting assembly is provided having a main housing and a lens assembly hinged to the main housing. The lens assembly has a body with end walls with a recess in an upper end of the end walls. The recess in each end wall has a dimension to receive and support a lens for directing light to the target area. The lens has a length greater than the length of the cover so that the ends of the lens extend beyond the outer edge of the end walls of the cover. Stop members are provided on the end walls to limit longitudinal movements of the lens with respect to the body of the lens assembly. A reflector extends from a bottom edge of the cover to an upper edge overlying a portion of the lens. A spring clip is provided to couple the lens to the reflector.