Patent SG-11201808907P-A (SG)
Title: Inhibitors of activin receptor-like kinase
Inventor: BROOIJMANS NATASJA
IPC: C07D519/00
Filed: 2017-04-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111 011101111110101 010 111111111011011# International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...,/ WO 2017/181117 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: Ayer, MA 01432 (US). WILSON, Kevin, J.; 38 Union C07D 487/04 (2006.01) A61K 31/5025 (2006.01) Park, Apt. 4, Boston, MA 02118 (US). C07D 519/00 (2006.01) A61P 19/00 (2006.01) (74) Agent: GEORGES EVANGELINOS, Asimina, T.; (21) International Application Number: Lando & Anastasi, LLP, Riverton Office Park, One Main PCT/US2017/027775 Street, Suite 1100, Cambridge, MA 02142 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 14 April 2017 (14.04.2017) kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, HN, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (30) Priority Data: KP, 62/322,948 15 April 2016 (15.04.2016) US MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/411,172 21 October 2016 (21.10.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: BLUEPRINT MEDICINES CORPORA- RU, TION [US/US]; 38 Sidney Street, Suite 200, Cambridge, TH, MA 02139 (US). ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (72) Inventors: BROOIJMANS, Natasja; 43 Concord Square, (84) Designated States (unless otherwise indicated, for every Apt. 2, Boston, MA 02118 (US). BRUBAKER, Jason, D.; kind 26 Sciarappa St Unit 1, Cambridge, MA 02141 (US). GM, TZ, of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventor: CRONIN, Mark (deceased). TJ, DK, Inventors: FLEMING, Paul, E.; 7 Sunnyside Ave, LV, Wellesley, MA 02482 (US). HODOUS, Brian, L.; 250 (72) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Chestnut Street, Cambridge, MA 02139 (US). KIM, GW, KM, ML, MR, NE, SN, TD, TG). Joseph, L.; 20 Green Way, Wayland, MA 01778 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, WAETZIG, Josh; 30 Livermore Road, Waltham, MA Published: 02451 (US). WILLIAMS, Brett; 24 Castleton St., Boston, with MA 02130 (US). WILSON, Douglas; 33 Mulberry Circle, international search report (Art. 21(3)) 1-1 IN 11 11 11 GC 11 IN 11 © ei (54) Title: INHIBITORS OF ACTWIN RECEPTOR-LIKE K1NASE C ) ,.. (57) : Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.