baber/WOPTO huggingface dataset:
Patent DE-69109109-D1 (DE)
Inventor: VARSHAVSKY ALEXANDER
IPC: C12N5/10
Filed: 1991-05-08
Granted: 1995-05-24
Abstract: A ubiquitin-specific protease which cleaves ubiquitin from any protein or peptide to which ubiquitin is joined and the gene encoding the protease are disclosed. The protease specifically cleaves the peptide bond in a fusion of ubiquitin to a protein or peptide between the carboxyl-terminal amino acid residue of a ubiquitin moiety and the  alpha -amino group of any non-ubiquitin protein or peptide to which ubiquitin is joined. Recombinant expression vectors containing a DNA sequence encoding the ubiquitin-specific protease can be used to transform cells for production of the protease or to provide the cell with the ability to proteolytically deubiquitinate, in vivo, ubiquitin fusions co-produced by the cell. The protease can also be isolated and used to deubiquitinate ubiquitin fusions in vitro. For those proteins or peptides whose functional activity is inhibited or otherwise modified by the presence of a ubiquitin moiety, this moiety can be used as a temporary inhibitor (or modifier) of the activity of a protein or peptide, with the ubiquitin-specific protease employed to restore, by deubiquitination, the original activity of the protein or peptide.
Patent DE-69126773-D1 (DE)
Inventor: KECK STEVEN
IPC: H01L23/02
Filed: 1991-02-25
Granted: 1997-08-14
Abstract: The present invention relates to the formation of a macrocomposite body by spontaneously infiltrating a permeable mass of filler material or a preform with molten matrix metal and bonding the spontaneously infiltrated material to at least one second material such as a ceramic or ceramic containing body and/or a metal or metal containing body. Particularly, an infiltration enhancer and/or infiltration enhancer precursor and/or infiltrating atmosphere are in communication with a filler material or a preform, at least at some point during the process, which permits molten matrix metal to spontaneously infiltrate the filler material or preform. Moreover, prior to infiltration, the filler material or preform is placed into contact with at least a portion of a second material such that after infiltration of the filler material or preform, the infiltrated material is bonded to the second material, thereby forming a sealable electronic package.
Patent DE-69130735-D1 (DE)
Inventor: TANG JORDAN
IPC: C07K14/47
Filed: 1991-04-04
Granted: 1999-02-18
Abstract: The complete structure of human milk BAL cDNA is disclosed. The nucleotide sequences of the cDNA inserts of two clones overlap and together contain 2951 base pairs of BAL cDNA which codes for an open reading frame of 720 amino acid residues between initiation and termination codons. There is a putative signal sequence of 20 residues which is followed by a 61-amino-terminal sequence of BAL. The cDNA sequence also contains a 678-base 5'-untranslated sequence, a 96-base 3'-untranslated region, and a 14-base poly(A) tail. The deduced BAL protein structure contains in the carboxyl-terminal region fourteen repeating units of 11 amino acids each. The repeating units have the basic structure of Pro-Val-Pro-Pro-Thr-Gly-Asp-Ser-Gly-Ala-Pro-, with only minor substitutions. The cDNA is useful for expression of protein, study of structure, function and the effect of modification or deletion or addition of amino acids, including entire repeating units, and as probes for studies involving BAL or related lipases, including rat pancreatic lysophospholipase, cholinesterase, and acetylcholinesterase. <IMAGE>   <IMAGE>
Patent DE-69205017-D1 (DE)
Inventor: NASU RIKUO
IPC: C07C209/74
Filed: 1992-01-23
Granted: 1995-11-02
Abstract: A process for producing 3,5-difluoroaniline, which comprises reacting a benzonitrile compound of the formula (I): <CHEM> wherein each of X1, X2 and X3 is hydrogen, chlorine, bromine or a cyano group, provided that at least one of X1 to X3 is a cyano group, with a mineral acid for hydrolysis and decarboxylation to obtain an aniline compound of the formula (II): <CHEM> wherein each of X4, X5 and X6 is hydrogen, chlorine or bromine, provided that at least one of X4 to X6 is hydrogen, and in the case of a compound of the formula (II) wherein X4, X5 and X6 are not simultaneously hydrogen, reacting such a compound with hydrogen in a presence of a catalyst for reduction to obtain 3,5-difluoroaniline.
Patent DE-69208364-D1 (DE)
Inventor: SCHWARTZ JACK
IPC: A47C23/00
Filed: 1992-08-11
Granted: 1996-03-28
Abstract: The mattress system provides adjustability for individuals. A stack of individual mattress elements includes separation sheets to allow the mattress elements to flex and compress separately. In a side by side arrangement for adjusting the mattress between sides for each of two users, modulator foam panels and a movement isolation foam block can be provided to reduce disturbance between sides and to make the centerline between sides more comfortable. Between side by side mattresses or between the mattress and a surrounding foam frame, edge separation sheets allow the mattresses to move up and down without catching or wearing at the interfaces.
Patent DE-69214640-D1 (DE)
Inventor: TRUMAN MARK
IPC: F16C1/14
Filed: 1992-05-21
Granted: 1996-11-21
Abstract: A cable length adjustment device comprising an elongated member, a locking member formed to prevent translatory movement of the elongated member when in a first locked position, and allow for translatory movement of the elongated member in a second unlocked position, and a housing substantially encasing the locking member.
Patent DE-69218279-D1 (DE)
Inventor: YANG TAI-HER
IPC: B25B21/00
Filed: 1992-04-07
Granted: 1997-04-24
Abstract: An automatic transmission with shifts dependent on the tangue load. It includes a first shaft (A) and a second shaft (B). On the first shaft (A) is rigidly connected a gear (101) and, by means of an overload ship clutch (106), a gear (102). On the second shaft (B) is rigidly connected a gear (104) and, by means of a one way clutch (105), a gear (103). The two gear sets (101,103) and (102,104) are continuosly mashing gears. <IMAGE>
Patent DE-69220384-D1 (DE)
Inventor: FENTON PAUL
IPC: A61M39/00
Filed: 1992-12-07
Granted: 1997-07-17
Abstract: A valved catheter is disclosed having an elongate, flexible tubular element defining a lumen extending along an axis substantially Parallel to the central axis of said tubular element, and a unidirectional valve assembly near its distal end which controls fluid flow in the tubular element. The valve is generally defined by a top flap portion and a base portion. The top flap portion includes a flap valve surface which is complementary to a base valve surface when there is substantially no pressure difference between the lumen and outside the catheter. When a pressure differential exists between the lumen and outside the catheter, the top valve surface and base valve surface separate to form an opening for fluid flow therethrough. The direction of fluid flow through the valve aperture is determined by the pressure differential. A multi-lumen catheter assembly is also disclosed.
Patent DE-69318959-D1 (DE)
Inventor: CUNAT PIERRE-JEAN
IPC: B21D39/03
Filed: 1993-12-28
Granted: 1998-07-09
Abstract: This process aims to manufacture sheet metal having a multilayer structure possessing improved properties, especially in the field of deep-drawing (stamping). This process is principally characterised in that two sheets of similar thicknesses are used, having different metallurgical compositions, which are subjected to a differential heating operation so as to generate a defined linear thermal expansion in each sheet, this operation being carried out before or after installing, between these two sheets, a viscoelastic film which ensures that they are bonded.
Patent DE-69322149-D1 (DE)
Inventor: NAKANISHI HIDEKI
IPC: B41J29/60
Filed: 1993-12-24
Granted: 1998-12-24
Abstract: A battery-driven recording apparatus records a plurality of lines by recording-scan by using a recording head having a plurality of recording elements. A capacity of a battery is detected, and when the capacity of the battery is lowered, the number of lines to be recorded in one recording scan is reduced. <IMAGE>
Patent DE-69331751-D1 (DE)
Inventor: IOVINO CLAUDIA
IPC: C08J11/08
Filed: 1993-10-15
Granted: 2002-04-25
Abstract: This invention is a method to speed up and prevent inconsistent rates of reaction in the reduction of volume of polystyrene foam products by the application of a liquid and vapors of a terpine or isoprenoid compound where a heat activation within 90 days of the use provides maximum reactivity. In one embodiment the process is localized by the addition of heaters in the processing vessels or tanks to insure active agent form of d-limonene reduction agent.
Patent DE-69332075-D1 (DE)
Inventor: CHEN MENG-HSIN
IPC: C07D495/20
Filed: 1993-12-08
Granted: 2002-08-08
Abstract: There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.
Patent DE-69333700-D1 (DE)
Inventor: LEHTONEN PENTTI
IPC: D21F3/08
Filed: 1993-02-05
Granted: 2004-12-23
Abstract: Method of a coating a roll in a paper machine with powder of thermoplastic speciality plastic and metal, ceramic or cermet particles. The coating is carried out by spraying by using hypersonic plasma with a velocity of about 2000 m/s or more. <IMAGE>
Patent DE-69400456-D1 (DE)
Inventor: CHOPIN THIERRY
IPC: C09D7/62
Filed: 1994-04-08
Granted: 1996-10-10
Abstract: Novel compositions based on coloured rare-earth sulphides of core-shell type, which are characterised in that they include (i) a support based on at least one rare-earth sesquisulphide of formula M2S3 in which M denotes at least one element taken from the group consisting of the lanthanides of atomic number between 57 and 71 inclusive, preferably cerium, and yttrium, the said support additionally containing at least one alkali metal and/or alkaline-earth metal element, preferably sodium, at least a part of which, and preferably all of which, is included in the crystal lattice of the said sesquisulphide, and (ii) a layer based on at least one transparent oxide, preferably silica, deposited at the surface of the said support and coating the latter. The invention also relates to a process for obtaining these compositions, which consists (i) in bringing the support and a precursor of the desired transparent oxide into contact, (ii) in precipitating, according to a number of possible methods (hydrolysis, basic precipitation or other), the transparent oxide and, finally, (iii) in separating the composite obtained from its reaction mixture.   Finally, it relates to the use of the said compositions for colouring various materials, in particular plastics.
Patent DE-69401207-D1 (DE)
Inventor: OBIDNIAK LOUIS
IPC: H02K47/00
Filed: 1994-04-29
Granted: 1997-01-30
Abstract: PCT No. PCT/CA94/00241 Sec. 371 Date Oct. 25, 1995 Sec. 102(e) Date Oct. 25, 1995 PCT Filed Apr. 29, 1993 PCT Pub. No. WO94/26018 PCT Pub. Date Nov. 10, 1994An electric motor-generator has a rotor (1), a stator including soft ferromagnetic cores (3, 5) and coils (4, 6), permanent magnets (2) having pole axes in a plane radial to an axis of rotation of the rotor, means for mounting the magnets, the cores and coils to the rotor and stator, and means for energizing the coils. The rotor is caused to rotate by attraction of the magnets to the cores (5) as the magnets and cores approach one another, an opposite attraction force between the magnets and the cores being neutralizeable by energizing the coils (6) as the magnets and cores move apart. The cores are C-shaped and a magnetic circuit is formed when the magnets and cores are in proximate alignment.
Patent DE-69413417-D1 (DE)
Inventor: SALLMANN ALFRED
IPC: C07C217/10
Filed: 1994-11-28
Granted: 1998-10-22
Abstract: PCT No. PCT/EP94/03937 Sec. 371 Date Jun. 10, 1996 Sec. 102(e) Date Jun. 10, 1996 PCT Filed Nov. 28, 1994 PCT Pub. No. WO95/15953 PCT Pub. Date Jun. 15, 1995   <IMAGE>  (I)  The invention relates to novel substituted oxazolidines of formula (I) wherein R1 and R2 are simultaneously hydrogen or both together are the identical lower alkyl radical, and to the salts thereof in racemic and chiral form, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments. The compounds have a stimulating effect on beta-adrenergic receptors and can be used, inter alia, for the treatment of diseases associated with reversible obstruction of the respiratory tract, typically asthma and chronic bronchitis, and also for inflammation of different origin.
Patent DE-69415998-D1 (DE)
Inventor: ROUANET STEPHANE
IPC: C01G25/00
Filed: 1994-11-07
Granted: 1999-02-25
Abstract: A method for providing aerogels, and aerogels produced according to the method is described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes. <IMAGE>
Patent DE-69417750-D1 (DE)
Inventor: CRAWFORD DONALD
IPC: A01N63/28
Filed: 1994-06-29
Granted: 1999-05-12
Abstract: This invention relates to a biocontrol formulation suitable for reducing the susceptibility of plants to fungal phytopathogens. In one aspect of the invention, a newly isolated strain of Streptomyces, Streptomyces WYEC 108, is incorporated into a suitable delivery medium and applied to plant seeds or plant roots.
Patent DE-69432707-D1 (DE)
Inventor: KUBOTA SUNAO
IPC: A61L26/00
Filed: 1994-09-16
Granted: 2003-06-26
Abstract: A wound-covering material, which comprises, at least a polymer having a sol-gel transition temperature in an aqueous solution thereof, shows a substantial water-insolubility at a temperature higher than the sol-gel transition temperature, and shows a reversible water-solubility at a temperature lower than the sol-gel transition temperature. Such a wound-covering material may closely be attached to a wound surface having a complex profile, since it may be placed on the wound surface in a liquid state. In addition, the wound-covering material may provide a wound-covering matter which may rapidly be converted into a gel state due to the temperature of the wound so as to be closely attached onto the wound surface, and is stably attached to the wound surface in close contact. The resultant covering matter is stable without being dissolved by exudate secreted from the wound surface and may prevent the secretion of the exudate until the completion of the wound surface healing so as to promote the process of the wound healing. <IMAGE>
Patent DE-69505707-D1 (DE)
Inventor: BONI GIORDANO
IPC: B66D1/58
Filed: 1995-02-17
Granted: 1998-12-10
Abstract: A traction limiting device for winches comprising: a fixed framework (2), constituted by two end cross-members (3,4) which are mutually connected by two parallel longitudinal members (5,6); two cross-members (7,8) which are provided with bushings for sliding along the longitudinal members (5,6), have means (9) for fixing below the winch, are mutually co-planar, and are parallel to the cable winding drum; retainer means (10) with adjustable strain which are interposed between the fixed framework (2) and one of the sliding cross-members; and a microswitch (18) which is circuitally connected to the power supply of the winch and is adapted to interrupt it when a relative motion of the sliding cross-member with respect to the fixed framework (2) is sensed. <IMAGE>
Patent DE-69511375-D1 (DE)
Inventor: PLANCHE JEAN-PASCAL
IPC: C08L95/00
Filed: 1995-11-08
Granted: 1999-09-16
Abstract: PCT No. PCT/FR95/01471 Sec. 371 Date Jul. 9, 1996 Sec. 102(e) Date Jul. 9, 1996 PCT Filed Nov. 8, 1995 PCT Pub. No. WO96/15193 PCT Pub. Date May 23, 1996Bitumen/polymer compositions having improved mechanical properties are produced by stirring together, at a temperature of 100-230 DEG  C., a bitumen or bitumen mixture, a sulphur-curable elastomer and a polymeric additive consisting of at least one functionalized olefin copolymer and a sulphur-donating coupling agent. The bitumen/polymer compositions may be used directly or in dilute form to make bituminous binders for road surfaces, coated materials and sealing coatings.
Patent DE-69526542-D1 (DE)
Inventor: PESSARA ULRICH
IPC: G01N33/53
Filed: 1995-06-22
Granted: 2002-06-06
Abstract: The invention relates to an antibody which inhibits the binding between u-PA and u-PAR to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited 7 July 1994 at Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM) with accession numbers DSM ACC2178 and DSM ACC2179 under the terms and conditions of the Budapest Treaty. The invention furthermore relates to a method for detecting or quantifying u-PAR or a glycosylation variant of u-PAR in a sample by use of an antibody according to the invention. Furthermore, the invention relates to a method for the manufacture of a therapeutic agent for preventing or counteracting localized proteolytic activity using of an antibody of the invention as well as to use of an antibody according to the invention for the preparation of a diagnostic agent which is capable of targeting a diagnostic to a cell that contains a u-PAR on the surface.
Patent DE-69528016-D1 (DE)
Inventor: HAMANN PHILIP ROSS
IPC: A61K47/48
Filed: 1995-06-01
Granted: 2002-10-10
Abstract: This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Patent DE-69531184-D1 (DE)
Inventor: BASCOULERGUE GERARD
IPC: A61B17/14
Filed: 1995-10-27
Granted: 2003-08-07
Abstract: The system consists of a column (26) connected to one end of an interstitial plate (28) designed to engage with the intercondyle recess of the femur, a thrust member (23) which fits onto the column and has two stops (25) which make simultaneous contact with distal sections of the femur, and a distal cutter guide (33) which extends perpendicular to the thrust member's contact plane (p-p'). The guide has a cutter slot (36) lying perpendicular to the plane (p-p') and a lateral bar (37) with holes for pins (42). The interstitial plate (28) is connected to the column (26) by an adapter (28a) which prevents any relative rotation between the plate and the column and has a wedge to fit into the inter-condyle recess of the portion of the femur which is not to be resected.
Patent DE-69532882-D1 (DE)
Inventor: BARKER JAMES
IPC: H04L69/40
Filed: 1995-01-05
Granted: 2004-05-19
Abstract: PCT No. PCT/GB95/00014 Sec. 371 Date Jul. 23, 1996 Sec. 102(e) Date Jul. 23, 1996 PCT Filed Jan. 5, 1995 PCT Pub. No. WO95/19082 PCT Pub. Date Jul. 13, 1995In a digital telecommunication system having data packages carrying identification data, the identification data is characterized in that it is unique to the package within a station and does not depend on the identity of the originating station.
Patent DE-69534502-D1 (DE)
Inventor: DOMAGALA MICHAEL
IPC: A61K31/63
Filed: 1995-07-11
Granted: 2006-02-16
Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula   <IMAGE>   where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R1 and R2 are substituent groups, X is   <IMAGE>   or SO2NR4Z, Y is H or SZ when n is 1, a single bond when n is 2; R4 and Z can be hydrogen or alkyl.
Patent DE-69534596-D1 (DE)
Inventor: KOMAN AHMET
IPC: A61K38/00
Filed: 1995-06-12
Granted: 2005-12-15
Abstract: The subject of the invention is a new protein called EPIL or placentin, its analogs showing EPIL/placentin-type activity, obtained by deletion and/or substitution. The invention also concerns a DNA molecule coding for a EPIL/placentin-type polypeptide. It finally concerns a pharmaceutical composition containing EPIL/placentin or a EPIL/placentin analog.
Patent DE-69609321-D1 (DE)
Inventor: PERSSON AKE
IPC: B60P1/64
Filed: 1996-02-08
Granted: 2000-08-17
Abstract: Mounting means for releasable, interchangeable superstructures (3) for various types of vehicles and working machines, comprising co-operating means (5, 6) between the releasable superstructure (3) and the vehicle (1) including several tie means (5) which are mounted projecting downwardly from the superstructure (3) on each side thereof and which are rotatable about a shaft of rotation (12) extending in the longitudinal direction of the vehicle, and matching connection and locking means (4) which are mounted in the vehicle chassis (2) or in a prefabricated intermediate frame (7) which is mounted on the said chassis (2), and which comprises a locking pin (15) which is movable normally to the longitudinal direction of the vehicle, and in which said tie means (5) and said locking means (4) are formed with conical surfaces (14, 16) arranged to co-operate with each other, whereby a displacement of a locking pin (15) towards the vehicle chassis (2) and an introduction thereof in a locking recess (13) of a tie means (5) makes the superstructure (3) become pulled down and be pressed against the vehicle chassis (2).
Patent DE-69621387-D1 (DE)
Inventor: KOBAYASHI MITSUNORI
IPC: H01L21/48
Filed: 1996-07-02
Granted: 2002-07-04
Abstract: A plate type member of a Cu-W and/or Mo alloy for a semiconductor device package which can be bonded to a ceramic member or the like with no trouble due to suppression of a warp in a heating step, and a package for a semiconductor device employing this plate type member are provided. In the plate type member (8) for a semiconductor device package consisting of a Cu-W and/or Mo alloy, the difference between alkaline earth metal contents in upper and lower halves along the thickness direction is not more than 10 ppm, or an alkaline earth metal content is not more than 5 ppm per W and/or Mo. This plate type member is manufactured by reducing the alkaline earth metal content in W and/or Mo raw material powder, or standing a skeleton (1) on a refractory plate (3) in Cu infiltration, for performing homogeneous heating and cooling in manufacturing thereby preventing maldistribution of the alkaline earth metal. <IMAGE>