baber/WOPTO huggingface dataset:
Patent CR-20160387-A (CR)
Title: Anticuerpos anti-cd38 para el tratamiento de la leucemia linfoblástica aguda.
Inventor: DOSHI PARUL
IPC: C07K16/40
Filed: 2015-02-25
Abstract: La descripción se refiere a terapias de combinación que usan anticuerpos anti-CD38. Específicamente, la descripción proporciona métodos para tratar a un sujeto que tiene leucemia linfoblástica aguda (ALL), con el uso de un anticuerpo anti-CD38, en donde el anticuerpo anti-CD38 induce la muerte de células de ALL in vitro por citotoxicidad mediada por células dependiente de anticuerpos (ADCC), fagocitosis celular dependiente de anticuerpos (ADCP), citotoxicidad dependiente de complemento (CDC), apoptosis, o modulación de la actividad enzimática de CD38 in vitro.
Patent CR-20190375-A (CR)
Inventor: KODURI RAO
IPC: C07K16/30
Filed: 2018-01-19
Abstract: La invención proporciona un anticuerpo pan-TGF-ß mejorado para el tratamiento de afecciones que están mediadas por TGF-ß, incluyendo enfermedades autoinmunitarias, afecciones fibróticas, y cánceres. También se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.The invention provides an improved pan-TGF-ß antibody for treatment of conditions that are mediated by TGF-ß, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
Patent CR-20220685-A (CR)
Title: Rip1k inhibitors
Inventor: DARWISH IHAB
IPC: A61K31/55
Filed: 2021-06-25
Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition. (I)
Patent EC-SP003508-A (EC)
Title: Formas polimorfas de un citrato de azobiciclo [2.2.2] octan-3-amina y sus composiciones farmaceuticas
Inventor: QUALLICH GEORGE JOSEPH
IPC: A61K31/439
Filed: 2000-06-01
Abstract: Una forma polimorfa cristalina individual del citrato de (2S,3S) -(metoxi-5-t-buti!fenilmetil-2-difenilmetil-I-azobiciclo[2,2,2) octan-3-amina (citrato monohidrato) y su composición farmacéutica. La composición farmacéutica de la forma polimorfa si el citrato monohidrato tiene la estabilidad necesaria para una formulación para tratar la emesis. La administración de esta composición farmacéutica es una forma de dosificación oral de liberación inmediata, preferiblemente en forma de comprimido o cápsula, o intravenosa.
Patent EC-SP003591-A (EC)
Title: Antibacterianos
Inventor: ASCHER GERD
IPC: A61K31/4196
Filed: 2000-07-28
Abstract: Un compuesto de la fórmula (gráfico), en donde R2 es arileno o heterocicleno; o R y R2 junto con el átomo de nitrógeno con el que están unido, forman un heterocicleno no aromático, y los otros residuos tienen diferentes significados, es útil como un producto farmacéutico, por ejemplo antimicrobiano.
Patent EC-SP034442-A (EC)
Title: Mezclas de polisacaridos derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
Inventor: VISKOV CHRISTIAN
IPC: A61K31/727
Filed: 2003-01-20
Abstract: La presente invención concierne las mezclas de polisacáridos derivados de la heparina, su procedimiento de preparación y los compuestos farmacéuticos que los contienen.
Patent EC-SP066567-A (EC)
IPC: F23G5/027
Filed: 2006-05-12
Abstract: The invention relates to a gasification boiler for the combustion of solid fuels, in particular bales of straw, for heating purposes and for the production of hot water. The inventive boiler is characterized by optimal combustion and ash separation. The aim of the invention is to carry out the combustion of small particles in the most complete manner possible and to achieve an almost total separation of the ashes from the combustion gas upstream of the heat exchangers. To achieve this, according to the first feature of claim 1, the combustion and gasification chamber comprises lateral depressions that are configured next to the central grating and combustion chamber. Coarse particles collect in said depressions, leaving the fine particles to be carried with the combustion gas into the combustion chamber. According to the second feature of said claim, a cylindrical combustion chamber, configured as an additional component, is connected to the outlet of the combustion chamber. Said secondary combustion chamber significantly increases the combustion time, allowing small particles and partially oxidized gases to burn completely. According to the third feature, a cylindrical ash separator, configured as an additional component, is connected to the combustion chamber.
Patent EC-SP088725-A (EC)
Inventor: SANTOS MURILLO JOSEFINA
IPC: A61K31/5375
Filed: 2008-09-09
Abstract: The present invention generally relates to pharmaceutical industry and to drug preparer pharmaceutical industry for prevention and/or treatment of Irritable Bowel Syndrome (IBS) and characteristic symptoms such as abdominal discomfort or pain associated with changes in defecation and frequently abdominal distension, in particular. The present invention, as compared with prior-art compositions for identical purposes, has the following advantages: fewer doses of each one of the active agents, greater speed of action and fewer side effects. The composition that reflects the teachings of the present invention comprises the synergic combination of an L-type calcium-channel blocking agent with selective action on the smooth muscle fiber of the gastrointestinal tract and an antiflatulence agent, and also pharmaceutically acceptable excipients.
Patent EC-SP900697-A (EC)
Title: Los activadores de proteina quinasa como realizadores de la produccion de melanina
Inventor: AGIN PATRICIA A
IPC: A61K8/73
Filed: 1990-11-07
Abstract: Se refiere a "un método para realzar la producción de melanina que comprende aplicar tópicamente a la piel una composición que comprende una cantidad eficaz de por lo menos un activador de proteína quinasa C. El activador PK-C se aplica en una cantidad eficaz para estimular la producción realzada de melanina. En general el activador PK-C se combina con un solvente apropiado y otros ingredientes opcionals". "Se ha descubierto de manera sorprendente e inesperada, que las aplicaciones tópicas de Activadores de Proteína Quinasa C son absorvidos en forma suficiente a través de la piel para efectuar una producción de melanina realzada, potenciada o incrementada".
Patent EC-SP972293-A (EC)
Title: Derivados de naftiridina
Inventor: HERSPERGER RENE
IPC: C07D471/00
Filed: 1997-10-27
Abstract: Las novedosas 8-aril-1,7-naftiridinas, en forma libre o de sal, constituyen inhibidores de PDE IV y, de esta manera, son útiles como productos farmacéuticos, por ejemplo, para la terapia contra el asma. Los componentes que se prefieren incluyen los compuestos de las fórmulas I y II, (gráfico), donde los grupos R son tal como se los define. Se presentan las composiciones farmacéuticas que comprenden los compuestos, los procedimientos para la preparción de los compuestos y los intermediarios novedosos para su uso en los procedimientos.
Patent FI-19992365-A (FI)
Inventor: MAELKKI YRJOE
IPC: C09B67/20
Filed: 1999-11-02
Abstract: The invention relates to a method for preparing an organic pigment from starch, and the pigment thus received. According to the invention, starch granules are swollen to increase their volume and plasticity, their stability towards changes in volume and shape is improved by cross-linking, by derivatization, or by making the surface hydrophobic, after which gas bubbles or cavities are formed inside the granules, these bubbles or cavities having a strong light scattering effect. Generating bubbles or cavities can be performed by evaporating water or another liquid, by releasing impregnated gas, by a gas generating reaction, or by displacing absorbed water with a solvent. The product is useful as a white pigment especially in coating of starch, in paints and in cosmetic products.
Patent GB-1051031-A (GB)
IPC: H03F5/00
Abstract: 1,051,031. Valve and transistor amplifying circuits. BAIRD & TATLOCK (LONDON) Ltd. Jan. 16, 1964 [March 5, 1963], No. 8740/63. Headings H3T and H3W. In an electrometer amplifier comprising a valve 1 with anode load 7, the emitter-collector path of a transistor 5 is connected between the anode and the load. The base is connected to a point of constant potential, which in the case of the valve 1 being a pentode may comprise the screen-grid. The arrangement maintains the anode of the valve at a substantially constant potential and so prevents the rapid rise of grid current which occurs with increasing anode potential.
Patent GB-1052905-A (GB)
IPC: H01H33/867
Abstract: 1,052,905. Gas-blast circuit-breakers. ALLMANNA SVENSKA ELEKTRISKA A.B. April 9, 1964 [April 10, 1963]. No. 14639/64. Heading H2B. A gas-blast circuit-breaker comprises a compressed air container 1, two series-connected pairs of contacts 5, 9 and 7, 10 each pair including a hollow movable contact, a common exhaust blast valve 13, a resistor 4 in parallel with the contacts 5, 9 the opening of which is controlled by the blast valve, and a separate control valve for controlling the opening of the contacts 7, 10. To open the circuit-breaker, compressed gas is applied through a pipe 32 to a piston 28 which opens the blast valve 13 to vent a space 11 to atmosphere. The compressed gas in the container 1 acting on a piston 14 opens the contact 9. When the blast valve is open, the piston 28 uncovers a pipe 26 so that compressed gas acts on a piston 24 to move a valve element 20 to shut off the supply of compressed gas to a cylinder 19 and to vent this cylinder to atmosphere. Compressed gas acting on a piston 18 now opens the contact 10. Compressed gas bleeds through a channel 31 in the piston 28 to equalize the pressures on both sides of the piston so that a spring 29 recloses the blast valve 13. The resulting increase in pressure in the space 11 permits a spring 17 to reclose the contacts 9, 5, but the contacts 10, 7 remain open until the pressure gas is vented from the pipe 32.
Patent GB-1054225-A (GB)
IPC: C08B37/02
Abstract: 1,054,225. Dextran. DOW CHEMICAL CO. March 24, 1965, No. 12537/65. Heading C2C. [Also in Division C3] Dextran and fructose are separated from an aqueous solution thereof by introducing a volume of the solution into a bed of particulate ion-exchange resin, eluating the resin with a like or greater volume of water, dividing the eluate from the resin into sequential fractions, and recovering dextran and fructose from the dextran-rich and fructose-rich fraction(s) respectively. The solution containing dextran and fructose, which may be the reaction mixture formed in the synthesis of dextran by enzymatic fermentation of sucrose, desirably contains equal quantities of dextran and fructose, the total solute content being 10-25 weight per cent. Several types of cation- and anionexchange resin are disclosed. The collected fractions of eluate are analyzed for solute content by spectrophotometric measurement after oxidation with chromic acid.
Patent GB-1084106-A (GB)
IPC: D04H11/00
Abstract: 1,084,106. Flocked webs. FARBENFABRIKEN BAYER A.G. Nov. 6, 1964 [Nov. 20, 1963], No. 45347/64. Heading B2E. A flocked porous grid fabric web comprises a warp and weft consisting of monofils of synthetic plastic material. The monofils may consist of polyamide such as polyamide-6, polyesters, polycarbonates, polyurethanes, acrylonitrile polymers, polyvinyl chloride, polyvinylidene chloride, polyolefins such as polyethylenes and polypropylenes. The grid fabric, which is a woven open mesh fabric, may be flocked on both sides. The fabric web may be fixed prior to the application e.g. by spraying. wiper blade, or by immersion followed by blowing through the fabric, of a flock adhesive which may be based on polyacrylates. Flocking may be by mechanical, electrostatic or combined methods. The flock may be a mixture of synthetic organic material and inorganic material, of synthetic fibres or cellulose fibres having a length of from 0.1 mm., to 5 mm. inclusive and a denier count of from 1 to 30 inclusive, of polyamide such as polyamide-6 fibres, viscose fibres, or fibres of polyester or polyacrylonitrile. The flocked web may be embossed, sheared, dyed or printed.
Patent GB-1084115-A (GB)
IPC: B66F9/16
Abstract: 1,084,115. Masted lift trucks. LANCERS MACHINERY Ltd. March 20, 1964 [March 26, 1963], No. 11989/63. Heading B8H. A frame 3, pivotally supporting fork arms 1 at 2, is connected to the lifting carriage 6 of a lift truck by pivoted links 4, 5 and an hydraulic ram 11. The distance between the pivot points 7, 8 is greater than that between the pivot points 9, 10 so that retraction of the ram raises the frame 3 and tilts it forwardly allowing the fork arms to be tilted downwardly. In a modification (not shown), the distance between the pivot points 7, 8 is less than that between the pivot points 9, 10 whereby retraction of the ram 11 tilts the fork arms upwardly. In a further modification (not shown), the frame 3 is omitted and the links 4, 5 are pivoted directly between the fork arms and the lifting carriage.
Patent GB-1143771-A (GB)
IPC: H04N7/16
Abstract: 1,143,771. Coin freed apparatus. UNITED GAS INDUSTRIES Ltd. 17 May, 1966 [20 Feb., 1965; 28 April, 1965], Nos. 7435/65 and 17777/65. Heading G4V. In prepayment television or radio, the receiving station has a coin-actuated device 6 to provide credit so that switches 50 can be actuated by an on-off knib 10 to operate the television, and also has a relay 30 which is sensitive to impulses from the transmitting station and is arranged to cancel the credit depending on the frequency of the impulses. The device 6 operates to rotate spindle 19, at the rear of which is a pinion 23 coacting with a gear-wheel 45 which turns, via gears 47, 48, two cam discs 40, 41. Cam disc 40 has a gradual change of radius whereas cam disc 41 has an operative part with a sudden radius change, the two discs being connected by a pin in a slot. They engage pin 54 to pivot lever 51, whereby switches 50 are moved in the closing direction if credit is available whilst providing a positive opening of the switches in the initial or " nocredit " position. The knob 10 operates two further cam discs 60, 61 to move, via bell-crank 61, the lever 51 to close or open switches 50 if the cams 40, 41 are in the " credit available " position. A pointer 69 moves with cams 40, 41 to indicate the credit available and a pin 70 is arranged to engage a stop 71 to limit the amount of credit. To cancel the credit as the television is operated, a relay 30 is responsive to impulses sent out from the transmitting station to move ratchet-wheels 28, 29 to rotate spindle 32. A gear 39 on this spindle engages with a differential gear 24 on spindle 19 to turn the pinion 23 and gear-wheel 45, and hence the cams 40, 41, in the opposite direction to that of the coinactuated device to return the cams 40, 41 to the initial " no-credit " position. A quantity mechanism 15, 16 can be incorporated so that different sizes of coins can be used and a coin counter 72 may be provided.
Patent GB-1225828-A (GB)
IPC: G03D15/02
Filed: 1968-12-31
Abstract: 1,225,828. Photographic apparatus. BELL & HOWELL CO. Dec. 31, 1968, No.61826/68. Heading G2A. A liquid applying and drying apparatus 10 has an applicator roller 21 for applying developer pumped from an adjustable weir 22 to one side of a sheet form member 13; and a nipless, rotatable drying roller 31, spaced from the roller 21, for engaging said side of the member 13 to remove substantially all of said liquid therefrom. In a photo-copier, the member 13 is guided by baffles 16 to transport rollers 19, 20, which in turn direct the sheet over the top of the roller 21. The weir 22 is connected by a conduit 24 to a source of liquid. An additional transport roller 28 engages the back of the member 13 and guides it towards transport rollers 29, 30 so as to pass over part of the surface 33 of the drying roller 31 which is rotating so that it is moving in a direction opposite to the member 13 when in contact therewith. An adjustable doctor blade 37 removes the liquid from the surface 33 of the roller. After leaving the rollers 29, 30, the member 13 is guided by baffles 44a, 44b to transport rollers 47, 48 and an exit slot 12.
Patent GB-1226173-A (GB)
IPC: G09G1/10
Filed: 1968-07-18
Abstract: 1,226,173. Cathode-ray tube displays. TELEFUNKEN PATENTVERWERTUNGS G.m.b.H. 18 July, 1968 [18 July, 1967], No. 34377/68. Heading H4T. In a cathode-ray tube display arrangement in which data code words defining Alpha- Numeric &c. symbols are derived sequentially and cyclically from a store, selected parts of the total contents of the store may be emphasized or may be displayed to the exclusion of the other parts. The selected parts are distinguished in the data code words in the store by the presence of a control code and a recognition code the latter being associated with a definite part of the contents of the store which are read-out subsequentially. As shown, the data code words are transferred sequentially and cyclically from the store BWS to a register R the loading of the data in the store being such that when the control code appears in stages ST the recognition code appears in stages K. The control code then operates via a reading circuit AS to block a gate T1, between the register R and a known circuit ZS controlling the deflection and intensity of the beam of the display cathode-ray tube and to open a gate T2 which passes the recognition code in Stages K to a recognition register KR which is thereby set to respond to the contents of the store related to the recognition code and subsequently read-out. The outputs from KR are then fed to AND gates KA ... KF having as second inputs signals derived from manuallyoperated switches TA ... TF by means of which the contents to be emphasized are selected. The AND gates thus produce an output when selected by the appropriate switches and these outputs are fed to an OR gate DT which supplies a signal to the beam intensity control circuit HS in which it acts as a gateoperating signal so that beam intensity signals pre-set in ZS by the control words take effect to the exclusion of beam intensity signals related to non-selected display parts. Alternatively, the manner of operation may be such that the beam intensity signals related to the latter parts continue to be effective so that these parts of the display are visible continuously, whilst the occurrence of an output signal from DT causes the selected parts to be displayed with an intensity flicker.
Patent GB-1227678-A (GB)
IPC: F26B5/06
Filed: 1969-08-29
Abstract: 1,227,678. Drying apparatus. NEW BRUNSWICK SCIENTIFIC CO. Inc. 29 Aug., 1969, No. 43095/69. Headings F4G and F4S. Freeze drying.-In a freeze drying apparatus, Fig. 1, having a vapour removal system comprising a vacuum manifold 10, two condensing trap means 1, 2, a refrigerating means 42, and a vacuum creating means 32, an automatic control means connects one trap means with the vapour removal system while shutting off the other for a first period of time, and shuts off the one trap means while connecting the other for a second period of time subsequent to the first, and repeats the cycle alternately. Material to be freeze dried is contained in flasks 22 connected to the vacuum manifold 10 through valves 20. The vacuum manifold is connected to the vacuum pump 32 through two parallel paths, each passing through one of the condensers 1, 2. The paths are controlled by valves which may be of the motor controlled pinch type, the motors being controlled by the timers 54, 56. Each condenser is supplied with coolant from a refrigerator 42 through conduits controlled by valves which are also controlled by the timers 54, 56. On the first cycle of operation V2, V4, V8 are closed manually, thus coolant flows to the first condenser 1 which is open to the vacuum manifold 10 and pump 32. When condenser 1 is almost frosted up the timer 56 opens valve V8 to precool condenser 2, after which valves V1, V3, V7 close and V2, V4 open, switching operation from condenser 1 to condenser 2. The heaters inside condenser 1 are then switched on and valve V5 opened to drain away the defrosted condensate. When condenser 2 is almost frosted up, the procedure is repeated to switch operation from condenser 2 to condenser 1. Liquid cooled condensers.-Each condenser, Fig. 3, has an inner enclosure 60, having a slightly sloping bottom 62 and is sealed by a cover 64 through which a tube 66 passes to communicate with the conduit 26 from the vacuum manifold 10. The outlet pipe 30 to the vacuum pump 32 also passes through the cover 64 which also forms the seal of an external enclosure 68 surrounding the inner enclosure 60. In the gap between the enclosures 60, 68 and spaced apart from both is wound a coil 36 through which coolant flows to and from the refrigerator 42 through conduits 40, 44. The coil is submerged in a heat exchanging fluid, ethylene glycol, which is introduced into the chamber through a filling tube 74. Around the outside of the condenser is a layer of insulation 70. A thermostat 80 controls the refrigerator 42 to regulate the temperature of the coolant. Electrical resistance heaters 86 are provided to defrost the inner enclosure 60, and a valved outlet 50 allows the defrosted condensate to drain away.
Patent GB-1227859-A (GB)
IPC: D01G7/08
Filed: 1968-04-18
Abstract: 1,227,859. Automatic feeding of bales to openers. CARDING SPECIALISTS (CANADA) Ltd. 18 April, 1968, No. 18394/68. Heading D1N. A bale-manipulating apparatus comprises a longitudinally extending stationary portion 13 having aligned inlet and outlet openings, a bale-carrying portion 12 capable of being positioned adjacent to the inlet opening, drive means for engaging the movable portion 12 when so positioned and capable of moving the movable portion 12 transversely through the inlet to a working position and from the working position out of the outlet, locking means for locking the movable portion 12 in the working position, and unloading means for moving a bale off the movable portion 12 when in the working position. As shown, baled cotton is automatically fed from movable trucks 12 to the reciprocating head of an opener and blender by a pusher dolly 20 moving from position D to position E. A loaded truck 12 which has been manually position in position A is automatically moved to position B by motor driven sprockets 79 engaging racks 75 on the truck and after unloading is automatically moved by further driving of the sprockets to position C for subsequent manual removal. Position B is defined by a stationary framework 13 which carries the sprockets. Signal means (106, 129) are provided for sensing when the truck is correctly positioned and to then cause actuation of electric motor 81 to cause the required rotation of the sprockets on forward movement of the pusher dolly. Pusher dolly is pulled forward by weights on the ends of chains 77 located in columns 23, 24, there being a brake 82 which is only completely released when a load is sensed to be present on a truck in position B. When no load is present switch 129 is not closed and brake is only partly released such that dolly moves forward at a retarded rate. In forward position E dolly contacts switch 125 which reverses the motor which is coupled to a reversible double direction clutch (Fig. 12 not shown). (For Figures see next page)